# Research Accelerating RUNX1 Exploration (RARE) Grant

**Funder:** ALSF
**Budget:** Up to $250,000
**Duration:** 2 years
**Consortium:** No
**Official call:** https://www.alexslemonade.org/campaign/researchers-reviewers/runx1
**Last verified:** 20 June 2026

## Eligibility & scope

Funds research aimed at developing therapies for RUNX1-familial platelet disorder (RUNX1-FPD), specifically targeting interception of the transition from clonal hematopoiesis to MDS/AML or prevention of cancer before clonal hematopoiesis. Currently open for applications.

## Summary

The ALSF Research Accelerating RUNX1 Exploration (RARE) Grant funds up to $250,000 over two years for research aimed at developing therapies for RUNX1-familial platelet disorder (RUNX1-FPD). The call prioritizes projects targeting interception of the transition from clonal hematopoiesis to MDS/AML, or prevention of malignancy before clonal hematopoiesis develops. This is a disease-specific, high-impact funding stream for researchers working on a rare but clinically urgent genetic disorder.

## Who should apply

- Researchers focused on RUNX1-familial platelet disorder or clonal hematopoiesis transitions
- Projects with a translational or therapeutic development aim
- Scientists at academic institutions, including MD/PhD clinician-scientists
- Teams targeting interception or prevention of MDS/AML progression

## Key dates

- Applications currently open; verify deadline on ALSF website
- Two-year project duration

## Tips for applicants

- Frame your project around the funder's specific priorities: early interception or prevention, not just treatment after malignancy onset.
- Include mechanistic detail on RUNX1 biology and how your approach targets the clonal hematopoiesis-to-MDS/AML transition specifically.
- Emphasize clinical relevance and pathway to therapeutic translation; ALSF prioritizes projects with near-term translational potential.

## Frequently asked questions

### How much does the ALSF RARE Grant award?

Up to $250,000 over a two-year project period.

### What research areas does the ALSF RARE Grant fund?

Research aimed at developing therapies for RUNX1-familial platelet disorder, with priority given to projects targeting interception of clonal hematopoiesis-to-MDS/AML progression or prevention before clonal hematopoiesis develops.

### Is the ALSF RARE Grant currently accepting applications?

Yes, applications are currently open; verify the submission deadline on the ALSF website.

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Source: [The Great Grantsby](https://grantsby.eu/grants/alsf-research-accelerating-runx1-exploration-rare-grant-2026) — EU grant monitoring for academic researchers. Always verify details on the funder's website before applying.

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