# Game Changer Grant

**Funder:** ChadTough DIPG Foundation
**Budget:** Up to $600,000 over 3 years ($200,000/year)
**Deadline:** 11 January 2027 (LOI due; call opens 16 October 2026)
**Duration:** 3 years
**Application:** LOI → invitation for full submission (24 February 2027) → full application (31 March 2027) → award (June 2027)
**Frequency:** Annual
**Next round:** 2026-10
**Official call:** https://chadtough.org/wp-content/uploads/2026/10/2027-Game-Changer-Application-FINAL-2.pdf
**Last updated:** 18 Oct 2026

## Eligibility & scope

Funds hypothesis-driven, innovative research projects aiming for groundbreaking discoveries in DIPG/DMG. Submitted via Proposal Central.

## Summary

The Game Changer Grant from ChadTough DIPG Foundation funds hypothesis-driven research into DIPG/DMG (diffuse intrinsic pontine glioma/diffuse midline glioma), offering up to $600,000 over three years ($200,000/year). The call targets researchers working on major unsolved challenges in these pediatric brain tumors, with applications proceeding through a letter of intent before a full proposal is invited. ChadTough runs this program annually via Proposal Central.

## Who should apply

- Researchers proposing hypothesis-driven, innovative projects on DIPG or DMG
- Investigators with projects addressing major unsolved challenges in these pediatric brain cancers
- Teams prepared for a multi-year, multi-stage funding process via Proposal Central

## Key dates

- Call opens 16 October 2026; LOI due 11 January 2027
- Full application due 31 March 2027, with award start 1 August 2027
- Three-year project duration, up to $200,000 per year

## Tips for applicants

- The LOI stage is a gating filter before full submission is invited, make the hypothesis and potential impact on DIPG/DMG unmistakably clear early on.
- Frame the project around a specific major challenge in the field rather than incremental extension of existing work, since the call emphasizes groundbreaking discovery.
- Submit through Proposal Central and track the LOI-to-full-application timeline carefully, as only invited applicants proceed to the March full proposal deadline.

## Frequently asked questions

### How much does the Game Changer Grant pay?

Up to $600,000 total over three years, capped at $200,000 per year.

### When is the Game Changer Grant deadline?

The LOI is due 11 January 2027, with the call opening 16 October 2026; invited full applications are due 31 March 2027.

### What research does the Game Changer Grant fund?

It funds hypothesis-driven, innovative research projects addressing major challenges in DIPG/DMG with potential for groundbreaking discoveries.

### Is the Game Changer Grant a multi-stage application?

Yes, applicants submit a letter of intent first, and only those invited proceed to a full application.

### Does ChadTough DIPG Foundation run this grant every year?

Yes, the Game Changer Grant is an annual call, with the next round expected to open October 2026.

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Source: [The Great Grantsby](https://grantsby.eu/grants/chadtough-dipg-foundation-game-changer-grant-2027-01) — EU grant monitoring for academic researchers. Always verify details on the funder's website before applying.

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