# Game Changer Grant

**Funder:** ChadTough DIPG Foundation
**Budget:** Up to $600k over 3 years (max $200k/year)
**Deadline:** 31 March 2027 (LOI due 2027-01-11; invitation for full submission 2027-02-24; full application due 2027-03-31. Opens October 16, 2026.)
**Duration:** 3 years
**Application:** 2-stage: LOI (2027-01-11) → invited full application (2027-03-31)
**Frequency:** Annual
**Next round:** 2026-10
**Official call:** https://chadtough.org/research/grant-application/
**Last updated:** 30 Aug 2026

## Eligibility & scope

Funds hypothesis-driven, innovative research projects addressing major challenges in DIPG/DMG with potential for groundbreaking discoveries. Focused on DIPG/DMG (diffuse intrinsic pontine glioma / diffuse midline glioma). Applications submitted via Proposal Central.

## Summary

The Game Changer Grant funds hypothesis-driven research projects tackling major challenges in DIPG and DMG (diffuse intrinsic pontine glioma and diffuse midline glioma), with up to $600,000 over three years available per project. This call is open to researchers with innovative approaches to these aggressive pediatric brain cancers, with a focus on groundbreaking discoveries. The ChadTough DIPG Foundation runs this programme annually with a two-stage review process.

## Who should apply

- Researchers with hypothesis-driven, innovative projects targeting DIPG or DMG biology
- Academic and clinical researchers focused on pediatric brain cancer
- Applicants capable of delivering results within three years and $600k total budget
- Teams with potential to advance the field toward clinical translation

## Key dates

- Letter of Intent due 11 January 2027
- Invited full applications due 31 March 2027
- Three-year project duration

## Tips for applicants

- Frame your research around a single major challenge in DIPG/DMG biology; the foundation prioritises hypothesis-driven work with clear translational potential.
- The LOI is highly competitive; use the 2-page format to demonstrate novelty and feasibility, not depth of preliminary data.
- Keep annual budget planning transparent, flag cost distribution across years and explain any year-to-year variation in your budget narrative.

## Frequently asked questions

### How much funding does the Game Changer Grant provide?

Up to $600,000 over three years, with a maximum of $200,000 per year.

### What is the application timeline for the Game Changer Grant?

The call opens 16 October 2026, with a Letter of Intent deadline 11 January 2027, followed by invited full applications due 31 March 2027.

### Who can apply for the Game Changer Grant?

Researchers with hypothesis-driven, innovative projects addressing major challenges in DIPG or DMG at academic and clinical institutions.

### Is the Game Changer Grant recurring?

Yes, the ChadTough DIPG Foundation runs this programme annually, with the next round opening in October 2026.

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Source: [The Great Grantsby](https://grantsby.eu/grants/chadtough-dipg-foundation-game-changer-grant-2027-03) — EU grant monitoring for academic researchers. Always verify details on the funder's website before applying.

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