# CZI Technologies for Spatiotemporal Omics in Live Tissue

**Funder:** CZI
**Budget:** Up to $1,500,000
**Duration:** 3-5 years
**Consortium:** No — single PI or team
**Application:** Single stage RFA
**TRL:** Technology development
**Frequency:** Periodic
**Official call:** https://chanzuckerberg.com/rfa/technologies-spatiotemporal-omics-live-tissue/
**Last verified:** 18 June 2026

## Summary

CZI Technologies for Spatiotemporal Omics in Live Tissue funds technology development projects combining live-tissue imaging with spatial omics, with budgets up to $1.5 million over 3-5 years. The call supports researchers and teams developing novel tools, platforms, or methods to visualize and analyse cellular and molecular processes in intact biological systems. This is a technology-focused RFA with rolling or periodic deadlines.

## Who should apply

- Researchers and engineering teams developing live-tissue imaging technologies
- Projects integrating spatial omics with in vivo or ex vivo imaging platforms
- Technology development rather than hypothesis-driven basic research
- Investigators at academic or research institutions with infrastructure for prototyping

## Key dates

- Rolling or periodic RFA, check CZI website for active call windows
- Single-stage submission
- 3-5 year project duration

## Tips for applicants

- CZI prioritises tools with clear pathway to adoption by the broader research community; emphasise accessibility and open-source or licensing strategy.
- Live-tissue relevance is non-negotiable; proposals purely on fixed tissue or in silico methods are less competitive.
- Include letters or partnerships from anticipated end-users (imaging cores, other research groups); social proof of utility strengthens technical proposals.

## Frequently asked questions

### How much funding can I get from the CZI Technologies for Spatiotemporal Omics call?

Up to $1.5 million per project over 3-5 years.

### What types of projects does this CZI call fund?

Technology development combining live-tissue imaging and spatial omics, novel platforms, instruments, software, or methods for visualising and analysing cells and molecules in intact tissues.

### Is this a one-off call or does CZI run it regularly?

CZI issues this RFA periodically; check the CZI grants portal for active windows and next deadline dates.

### Can I apply as a single investigator or do I need a consortium?

Single PI or small team structures are eligible; formal multi-institutional consortia are not required.

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Source: [The Great Grantsby](https://grantsby.eu/grants/czi-spatiotemporal-omics-2026) — EU grant monitoring for academic researchers. Always verify details on the funder's website before applying.

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