# Proof of Concept

**Funder:** MRC (UKRI)
**Budget:** No limit stated; 80% FEC funded
**Deadline:** 18 November 2026 (4:00pm UK time)
**Duration:** No limit; projects start 1–6 months after funding decision
**Consortium:** No
**Application:** 2-stage: stage one application → invited stage two
**Eligible countries:** GB
**Official call:** https://www.ukri.org/opportunity/mrc-proof-of-concept-stage-one/
**Last updated:** 8 Jul 2026

## Eligibility & scope

Academically-led translational projects developing novel therapeutics, devices, diagnostics or interventions from early prototype through to phase 2a clinical studies. Project lead must be employed by an eligible UK research organisation; international researchers may participate as project co-lead (international). Funds 80% FEC; no matched funding required beyond standard 20% FEC.

## Summary

The MRC Proof of Concept call funds academically-led translational projects developing novel therapeutics, devices, diagnostics or interventions from early prototype through phase 2a clinical studies. Project leads must be employed by a UK research organisation, though international researchers may co-lead; the MRC funds 80% of full economic costs with no requirement for matched funding beyond the standard 20%. This is a competitive, two-stage call with no stated budget cap per project.

## Who should apply

- Project leads employed by eligible UK research organisations (universities, NHS trusts, research institutes)
- Translational researchers with early-stage prototype or candidate therapeutic, device, diagnostic or intervention
- Teams ready to progress toward phase 2a clinical studies
- Applicants comfortable with two-stage competitive review; international co-leads welcome but project lead must be UK-based

## Key dates

- Deadline: 18 November 2026, 4:00pm UK time
- Two-stage process: stage one written application followed by invited stage two
- Projects begin 1-6 months after funding decision

## Tips for applicants

- Translational stage and clinical progression pathway are central: articulate clearly how the prototype moves toward phase 2a and what de-risks that journey.
- The 80% FEC model means your host organisation covers only 20%, check whether your institution will absorb this before applying.
- International co-leads strengthen global relevance, but the project lead's UK employment is non-negotiable for eligibility.

## Frequently asked questions

### Who can be the project lead for an MRC Proof of Concept grant?

The project lead must be employed by an eligible UK research organisation. International researchers may participate as a project co-lead but cannot be the lead applicant.

### What funding level does MRC Proof of Concept offer?

The MRC funds 80% of full economic costs (FEC); your host organisation covers the remaining 20% and no additional matched funding is required.

### What is the deadline for MRC Proof of Concept?

The deadline is 18 November 2026 at 4:00pm UK time, using a two-stage application process.

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Source: [The Great Grantsby](https://grantsby.eu/grants/mrc-proof-of-concept-2026-11) — EU grant monitoring for academic researchers. Always verify details on the funder's website before applying.

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