[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-advanced-grant-2018":3,"awarded-stats-erc-advanced-grant":1111},{"awarded":4,"total":1110},[5,16,22,29,36,42,47,53,58,65,72,77,83,89,94,99,104,108,115,121,128,132,137,144,150,156,162,168,173,180,186,193,199,205,210,217,223,229,234,240,245,252,256,262,268,274,280,285,291,296,302,307,313,318,325,331,337,343,349,354,359,364,370,375,380,386,392,398,403,409,414,419,423,428,433,438,443,449,455,460,466,472,477,482,487,492,497,503,509,514,519,523,528,532,537,542,547,552,557,562,567,573,579,585,591,598,605,611,617,623,628,633,639,645,651,656,660,665,670,676,682,688,694,700,706,712,718,724,728,733,738,744,749,755,761,766,770,775,781,787,792,798,803,808,813,819,826,831,837,843,849,855,860,867,873,878,883,889,894,899,904,909,914,919,924,930,934,939,944,949,955,960,965,971,978,982,987,992,997,1002,1006,1010,1015,1020,1025,1030,1036,1042,1047,1052,1057,1063,1068,1073,1078,1082,1087,1093,1099,1104],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-european-research-council-award-adg-biotime-250189-","European Research Council","ERC Advanced Grant","From individuals to communities: How singleton invasive pine saplings lead to biodiversity change in the Brazilian Cerrado hotspot","Alessandra Kortz","University of St Andrews","GB",2018,null,"Abstract Questions How do newly established species interact with existing assemblage members to alter local biodiversity? This question is especially topical given growing concerns about increased temporal turnover levels relative to background rates. Pine ( Pinus spp.), a major invasive taxon in the Southern Hemisphere, is progressively dominating remaining fragments of the Brazilian savanna (Cerrado), a biodiversity hotspot. Because the Cerrado's diversity is linked to habitat heterogeneity w",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":21,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2012-adg","Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors","Roberto Mallone","Délégation Paris 5","FR",{"id":23,"funder":7,"programme":8,"title":24,"piName":25,"institution":26,"country":27,"year":13,"amount":14,"abstract":28},"openalex-european-research-council-award-erc2014-adg-669505","Intense structures of different momentum fluxes in turbulent channels","Javier Jiménez","Universidad Politécnica de Madrid","ES","The effects of the ambiguity in the definition of the Reynolds stresses to the coherent structures in wall turbulence are studied. It is confirmed that sweeps, ejections, and rollers are robust features of the flow.",{"id":30,"funder":7,"programme":8,"title":31,"piName":32,"institution":33,"country":34,"year":13,"amount":14,"abstract":35},"openalex-european-research-council-award-erc-2012-adg-20120216-320683","Methylated Nucleobases: Synthesis and Evaluation for Base Pairing In Vitro and In Vivo","Piet Herdewijn","Rega Institute for Medical Research","BE","Abstract The synthesis, base pairing properties and in vitro (polymerase) and in vivo ( E. coli ) recognition of 2′‐deoxynucleotides with a 2‐amino‐6‐methyl‐8‐oxo‐7,8‐dihydro‐purine ( X ), a 2‐methyl‐6‐thiopurine ( Y ) and a 6‐methyl‐4‐pyrimidone ( Z ) base moiety are described. As demonstrated by T m measurements, the X and Y bases fail to form a self‐complementary base pair. Despite this failure, enzymatic incorporation experiments show that selected DNA polymerases recognize the X nucleotide ",{"id":37,"funder":7,"programme":8,"title":38,"piName":39,"institution":40,"country":12,"year":13,"amount":14,"abstract":41},"openalex-european-research-council-award-erc-2013-adg","Observing substructure in circumstellar discs around massive young stellar objects","Marija R. Janković","Imperial College London","Simulations of massive star formation predict the formation of discs with significant substructure, such as spiral arms and clumps due to fragmentation. Here we present a semi-analytic framework for producing synthetic observations of discs with substructure, in order to determine their observability in interferometric observations. Unlike post-processing of hydrodynamical models, the speed inherent to our approach permits us to explore a large parameter space of star and disc parameters, and th",{"id":43,"funder":7,"programme":8,"title":44,"piName":45,"institution":46,"country":21,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-adg-319067-intecocis","Delayed-time domain impedance boundary conditions (D-TDIBC)","Quentin Douasbin","Centre National de la Recherche Scientifique",{"id":48,"funder":7,"programme":8,"title":49,"piName":50,"institution":51,"country":27,"year":13,"amount":14,"abstract":52},"openalex-european-research-council-award-erc-2012-adg-320737","Differential gene transcription across the life cycle in Daphnia magna using a new all genome custom-made microarray","Bruno Campos","Institute of Environmental Assessment and Water Research","Our results define major characteristics of transcriptional programs involved in the life-cycle, differentiate males and females, and show that large scale gene-transcription data collected in whole animals can be used to identify genes involved in specific biological and biochemical processes.",{"id":54,"funder":7,"programme":8,"title":55,"piName":56,"institution":11,"country":12,"year":13,"amount":14,"abstract":57},"openalex-european-research-council-award-erc-2011-adg","Clumpy shocks as the driver of velocity dispersion in molecular clouds: the effects of self-gravity and magnetic fields","Duncan H. Forgan","DHF and IAB gratefully acknowledge support from the ECOGAL project, grant agreement 291227, funded by the European Research Council under ERC-2011-ADG.",{"id":59,"funder":7,"programme":8,"title":60,"piName":14,"institution":61,"country":62,"year":13,"amount":63,"abstract":64},"cordis-european-research-council-award-786602","Novel mechanisms of early defense against virus infections","AARHUS UNIVERSITET","DK","€2,480,338","Virus-induced type I interferons (IFN) have classically been considered to constitute the first line of defense against virus infections However, recent work by us and others has identified early antiviral actions that occur independently of inducible type I and III IFN expression and sometimes even prior to IFN action (e.g. Iversen,...., Paludan. Nature Immunology, 2016; Paludan. Trends in Immunology, 2016). These discoveries challenge the current thinking in the field that IFNs constitute the ",{"id":66,"funder":7,"programme":8,"title":67,"piName":14,"institution":68,"country":69,"year":13,"amount":70,"abstract":71},"cordis-european-research-council-award-787932","The Evolution of Bacterial Warfare","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","UK","€2,750,137","Many bacteria are extremely aggressive. They assemble poisoned molecular spears to stab neighbours, they release protein machines that punch holes in competitors and, moreover, some cells will commit suicide in order to launch their attack. While there is a large literature on the evolution of combat and competition in animals, this has focused on why animals are generally reluctant to fight. The evolution of extreme aggression in bacteria, therefore, challenges our current understanding of comp",{"id":73,"funder":7,"programme":8,"title":74,"piName":14,"institution":68,"country":69,"year":13,"amount":75,"abstract":76},"cordis-european-research-council-award-789274","Single cell correlates of memory, motivation and individuality","€2,499,055","Directed behavior emerges from neural integration of sensory stimuli, memory of prior experience andinternal states. We seek an understanding of these conserved neural mechanisms using genetically-encodedtools and the relatively small brain of the fruit fly Drosophila. By temporally controlling neural functionmemories can be implanted and internal states altered so that most flies behave according to our direction.Our recent studies have revealed a role for distinct subsets of dopaminergic neuro",{"id":78,"funder":7,"programme":8,"title":79,"piName":14,"institution":80,"country":21,"year":13,"amount":81,"abstract":82},"cordis-european-research-council-award-786919","TRapped ENSembles of Circular RYdBErg atoms for quantum simulation","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€2,240,000","TRENSCRYBE proposes a groundbreaking concept for a quantum simulator (QS) of spin systems. QSs aim at an in-depth understanding of many-body physics, important for fundamental issues (quantum transport, phase transitions), but also for the development of engineered materials. A QS transcribes the system of interest into another with the same dynamics but with a fully controlled Hamitlonian parameter set. It provides a complete access to all the systems observables and allows the exploration of r",{"id":84,"funder":7,"programme":8,"title":85,"piName":14,"institution":86,"country":21,"year":13,"amount":87,"abstract":88},"cordis-european-research-council-award-785908","Human, Woven, Tissue-Engineered Blood Vessels (TEBV) Exclusively from Cell-Assembled Extracellular Matrix (CAM).","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","€2,491,543","Synthetic vascular grafts perform very poorly in small diameter applications (coronary\u002Fperipheral bypass) and for dialysis access. Better vascular conduits for these applications would be life and limb-saving for a very large patient population. A biological, human, tissue-engineered blood vessel (TEBV) may be such a device. We have developed a method to produce robust sheets of cell-assembled extracellular matrix (CAM) from normal, adult, human fibroblasts in vitro. These have been rolled into ",{"id":90,"funder":7,"programme":8,"title":91,"piName":14,"institution":80,"country":21,"year":13,"amount":92,"abstract":93},"cordis-european-research-council-award-788553","Targeting Root Hydraulic Architecture to improve Crops under Drought","€2,498,100","Water is the most limiting environmental factor for agricultural production worldwide and climate change exacerbates this threat. The HyArchi project will address this issue from a plant biology perspective and proposes new strategies to improve crop tolerance to drought. The main objective is to optimize water uptake and transport in cereals affected by drought. HyArchi will target maize, a major crop and a foundational model in plant genetics and water relations that is grown in irrigation or ",{"id":95,"funder":7,"programme":8,"title":96,"piName":14,"institution":86,"country":21,"year":13,"amount":97,"abstract":98},"cordis-european-research-council-award-741167","INTEGRATION AND PROPAGATION OF IMMUNOLOGICAL SIGNALS DURING CANCER AND INFECTION","€2,499,994","The immune system uses both short- and long-range communication mechanisms to mount the coordinated and sophisticated cellular responses required to control microbial infections or fight tumors. Yet, our understanding of how immunological signals are integrated and propagated by individual cells in complex tissue microenvironments remains largely limited.ENLIGHTEN is a research program dedicated to establish new mechanisms by which the immune system fight tumors or infections, based on the direc",{"id":100,"funder":7,"programme":8,"title":101,"piName":14,"institution":80,"country":21,"year":13,"amount":102,"abstract":103},"cordis-european-research-council-award-788972","Transgenerational epigenetic inheritance of chromatin states : the role of Polycomb and 3D chromosome architecture","€2,500,000","Epigenetic inheritance entails transmission of phenotypic traits not encoded in the DNA sequence and, in the most extreme case, Transgenerational Epigenetic Inheritance (TEI) involves transmission of memory through multiple generations. Very little is known on the mechanisms governing TEI and this is the subject of the present proposal. By transiently enhancing long-range chromatin interactions, we recently established isogenic Drosophila epilines that carry stable alternative epialleles, define",{"id":105,"funder":7,"programme":8,"title":106,"piName":14,"institution":86,"country":21,"year":13,"amount":102,"abstract":107},"cordis-european-research-council-award-786467","Mitochondrial Cannabinoid Receptors in the Brain","Brain activity critically depends on the high energetic support provided by mitochondria, the cell organelles transformingenergy sources into molecularly usable ATP. The pathological effects of chronic mitochondrial dysfunctions in the brain areunder scrutiny, but the impact of physiological modulation of mitochondrial activity on ongoing brain functions is almostunknown. Cannabinoid type-1 receptors (CB1) are amongst the G Protein-Coupled receptors (GPCR) expressed at highestlevels in the brain",{"id":109,"funder":7,"programme":8,"title":110,"piName":14,"institution":111,"country":112,"year":13,"amount":113,"abstract":114},"cordis-european-research-council-award-785932","Renormalization group approach to the collective behaviour of strongly correlated biological systems","CONSIGLIO NAZIONALE DELLE RICERCHE","IT","€2,301,250","Biological systems displaying collective behaviour are characterized by strong spatio-temporal correlations, which partly transcend the multiform diversity of their microscopic details, much as it happens in statistical physics systems close to a critical point. Recent experiments show that collective biological systems conform to another hallmark of statistical physics, namely scaling. Scaling laws have been found to be valid both at the static and at the dynamic level, although with critical e",{"id":116,"funder":7,"programme":8,"title":117,"piName":14,"institution":118,"country":112,"year":13,"amount":119,"abstract":120},"cordis-european-research-council-award-786714","Light-Induced Function: from Excitation to Signal through Time and Space","UNIVERSITA DI PISA","€2,400,000","Organisms of all domains of life are capable of sensing, using and responding to light. The molecular mechanisms used are diverse, but most commonly the starting event is an electronic excitation localized on a chromophoric unit bound to a protein matrix. The initial excitation rapidly “travels” across space to be converted in other forms of energy and finally used to complete the biological function. The whole machinery spans many different space and time scales: from the ultrafast electronic p",{"id":122,"funder":7,"programme":8,"title":123,"piName":14,"institution":124,"country":125,"year":13,"amount":126,"abstract":127},"cordis-european-research-council-award-787367","Parametrized Verification and Synthesis","TECHNISCHE UNIVERSITAET MUENCHEN","DE","€2,354,000","Parameterized systems consist of an arbitrary number of replicated agents with limited computational power, interacting to achieve common goals. They pervade computer science. Classical examples include families of digital circuits, distributed algorithms for leader election or byzantine agreement, routing algorithms, and multithreaded programs. Modern examples exhibit stochastic interaction between mobile agents, and include robot swarms, molecular computers, and cooperating ant colonies.A para",{"id":129,"funder":7,"programme":8,"title":130,"piName":14,"institution":124,"country":125,"year":13,"amount":102,"abstract":131},"cordis-european-research-council-award-788031","Extreme Quantum Matter in Solids","Quantum stochastic processes in solids, representing many-body systems par excellence, are believed to lead to extreme forms of quantum entanglement and non-local correlations (extreme quantum matter), that offer a well-defined starting point for an understanding of a wide range of anomalous materials properties, as well as emergent electronic phases such as magnetically mediated superconductivity or partial spin and charge order. While overwhelming experimental evidence clearly suggests a break",{"id":133,"funder":7,"programme":8,"title":134,"piName":14,"institution":80,"country":21,"year":13,"amount":135,"abstract":136},"cordis-european-research-council-award-787904","The origin and early evolution of eukaryotic plastids","€2,499,986","More than 1 Ga ago, an ancient eukaryote became photosynthetic by engulfing a cyanobacterium that evolved into the first plastid. This had profound consequences for the planet: photosynthetic eukaryotes became major primary producers and biogeochemical players. From this primary endosymbiosis evolved green algae and plants, red algae, and glaucophytes. Later, secondary endosymbioses of red and green algae spread plastids in numerous other phyla. However, many aspects of this evolutionary history",{"id":138,"funder":7,"programme":8,"title":139,"piName":14,"institution":140,"country":141,"year":13,"amount":142,"abstract":143},"cordis-european-research-council-award-788321","Design for changing values: a theory of value change in sociotechnical systems","TECHNISCHE UNIVERSITEIT DELFT","NL","€2,477,513","One of the key insights from the philosophy of technology is that technological artifacts and sociotechnical systems are not value neutral but supports or inhibits certain values. Several philosophical accounts for understanding the embedding of values in technological artifacts have been proposed and approaches like Value Sensitive Design, Design for Values and Responsible Research and Innovation have been established for integrating values into technical design. A blind spot is, however, the p",{"id":145,"funder":7,"programme":8,"title":146,"piName":14,"institution":147,"country":125,"year":13,"amount":148,"abstract":149},"cordis-european-research-council-award-787356","Mechanisms to emerge and replicate  the first sequence information of life in geothermal microfluidics of early Earth","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€2,364,500","Can we reconstruct in the lab the onset of molecular evolution? To trigger the autonomous emergence of the first oligonucleotide sequences, we will explore non-equilibrium boundary conditions and selective mechanisms to host the fast progressing prebiotic replication chemistry of oligonucleotides. We will explore novel water-fog microfluidic settings to boost the replication and selection of the first RNA sequences. The findings aims to enable the creation of primitive life forms in the lab, sta",{"id":151,"funder":7,"programme":8,"title":152,"piName":14,"institution":153,"country":34,"year":13,"amount":154,"abstract":155},"cordis-european-research-council-award-788298","Generalizing human-demonstrated robot skills","KATHOLIEKE UNIVERSITEIT LEUVEN","€2,494,971","Future robots are expected to perform a multitude of complex tasks with high variability, in close collaboration or even physical contact with humans, and in industrial as well as in non-industrial settings. Both human-robot interaction and task variability are major challenges. A lot of progress is needed so that: (1) robots recognize the intention of the human and react with human-like motions; (2) robot end-users, such as operators on the factory floor or people at home, are able to deploy ro",{"id":157,"funder":7,"programme":8,"title":158,"piName":14,"institution":159,"country":21,"year":13,"amount":160,"abstract":161},"cordis-european-research-council-award-786587","INNOVATION, FIRM DYNAMICS AND GROWTH: what do we learn from French firm-level data?","COLLEGE DE FRANCE","€1,968,588","This research project will confort theory and data to deepen our understanding of the mechanisms and policies of innovation, and the relationship between innovation, growth and social mobility. The underlying framework is the Schumpeterian theory of economic growth, where: (i) growth is generated by innovative entrepreneurs; (ii) entrepreneurial investments respond to incentives that are themselves shaped by economic policies and institutions; (iii) new innovations involves creative destruction.",{"id":163,"funder":7,"programme":8,"title":164,"piName":14,"institution":165,"country":125,"year":13,"amount":166,"abstract":167},"cordis-european-research-council-award-787515","Probing Majorana quasi-particles and ballistic spin-momentum locking in topolocical insulator nanostructures","UNIVERSITAET REGENSBURG","€2,498,887","Three-dimensional topological insulators (3D-TI) feature an insulating bulk and conducting surface states. The energy spectrum of these surface states mimics the one of relativistic Dirac electrons, i.e., it is linear in wave-vector k, not spin-degenerate and the spin locks to the k-vector (spin-momentum locking (SML)). The lack of spin degeneracy makes TIs a promising system for detecting quasi-particles with properties of Majorana fermions (MF), being potentially useful for fault tolerant quan",{"id":169,"funder":7,"programme":8,"title":170,"piName":14,"institution":171,"country":112,"year":13,"amount":14,"abstract":172},"cordis-european-research-council-award-789049","From Micro to Macro: Aggregate Implications of Firm-Level Heterogeneity in International Trade","UNIVERSITA COMMERCIALE LUIGI BOCCONI","What determines the patterns of international trade and the associated welfare effects? Can individualincentives to trade diverge from societal objectives? Should governments intervene to promote or restrictinternational transactions? Questions like these have recently gained new salience, in Europe and elsewhere,due to renewed protectionist pressures and resurgent nationalistic tendencies arising from diffusedisenchantment with globalization.The aim of the research project is to highlighting ke",{"id":174,"funder":7,"programme":8,"title":175,"piName":14,"institution":176,"country":177,"year":13,"amount":178,"abstract":179},"cordis-european-research-council-award-787390","Cloud Computing via Homomorphic Encryption and Multilinear Maps","UNIVERSITE DU LUXEMBOURG","LU","€2,491,266","The past thirty years have seen cryptography move from arcane to commonplace: Internet, mobile phones, banking system, etc. Homomorphic cryptography now offers the tantalizing goal of being able to process sensitive information in encrypted form, without needing to compromise on the privacy and security of the citizens and organizations that provide the input data.  More recently, cryptographic multilinear maps have revolutionized cryptography with the emergence of indistinguishability obfuscati",{"id":181,"funder":7,"programme":8,"title":182,"piName":14,"institution":183,"country":34,"year":13,"amount":184,"abstract":185},"cordis-european-research-council-award-741097","Load Slice Core: A Power and Cost-Efficient Microarchitecture for the Future","UNIVERSITEIT GENT","€2,499,500","The ideal processor building block is a power and cost-efficient core that can maximize the extraction of memory hierarchy parallelism, a combination that neither traditional in-order nor out-of-order cores provide. We propose the Load Slice Core microarchitecture, a restricted out-of-order engine aimed squarely at extracting memory hierarchy parallelism, which, according to preliminary results, delivers a nearly 8 times higher performance per Watt per euro compared to an out-of-order core. The ",{"id":187,"funder":7,"programme":8,"title":188,"piName":14,"institution":189,"country":190,"year":13,"amount":191,"abstract":192},"cordis-european-research-council-award-787157","Proteomic fingerprinting of functionally characterized single synapses","HUN-REN KISERLETI ORVOSTUDOMANYI  KUTATOINTEZET","HU","€2,498,750","Our astonishing cognitive abilities are the consequence of complex connectivity within our neuronal networks and the large functional diversity of excitable nerve cells and their synapses. Investigations over the past half a century revealed dramatic diversity in shape, size and functional properties among synapses established by distinct cell types in different brain regions and demonstrated that the functional differences are partly due to different molecular mechanisms. However, synaptic dive",{"id":194,"funder":7,"programme":8,"title":195,"piName":14,"institution":196,"country":69,"year":13,"amount":197,"abstract":198},"cordis-european-research-council-award-787764","Do Pathogen Extracellular Vesicles Deliver Crop Disease?","UNIVERSITY OF DUNDEE","€2,468,260","Filamentous plant pathogens (fungi and oomycetes) cause the most devastating crop diseases and thus significantly threaten global food security. Essential components of their virulence arsenal are proteins called cytoplasmic effectors that are delivered inside plant cells to suppress immunity. One of the major scientific challenges in this field is understanding how effectors are secreted and translocated into host cells; a question that is hotly debated. An exciting breakthrough in my laborator",{"id":200,"funder":7,"programme":8,"title":201,"piName":14,"institution":202,"country":125,"year":13,"amount":203,"abstract":204},"cordis-european-research-council-award-788558","Selective Hydrogenation of Arenes - A Dream Reaction","UNIVERSITAET MUENSTER","€2,495,000","The hydrogenation of ketones and olefins is one of the oldest synthetically used transformations. The reaction is highly sustainable and its value has been acknowledged by two Nobel Prizes. In contrast, the hydrogenation of arenes is still underexplored due to the high kinetic barrier caused by aromaticity. However, the selective arene hydrogenation constitutes a dream reaction for use in an ideal synthesis: The transformation is straightforward, uses readily available substrates, and is able to",{"id":206,"funder":7,"programme":8,"title":207,"piName":14,"institution":208,"country":69,"year":13,"amount":14,"abstract":209},"cordis-european-research-council-award-742349","Game-changing Precision Medicine for Curing All Myeloproliferative Neoplasms","UNIVERSITY OF GLASGOW","Despite decades of research, developing ways to overcome drug resistance in cancer is the most challenging bottleneck for curative therapies. This is because, in some forms of cancer, the cancer stem cells from which the diseases arise are constantly evolving, particularly under the selective pressures of drug therapies, in order to survive. The events leading to drug resistance can occur within one or more individual cancer stem cell(s) – and the features of each of these cells need to be studi",{"id":211,"funder":7,"programme":8,"title":212,"piName":14,"institution":213,"country":214,"year":13,"amount":215,"abstract":216},"cordis-european-research-council-award-787478","Nationalist State Transformation and Conflict","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","CH","€2,631,556","Scholars studying contemporary conflict and development have increasingly turned to the historical roots of state formation. Going beyond Tilly’s classical theory of state formation, the NASTAC project creates a new theory of nationalist state transformation that will be evaluated with historical maps and archival data extracted through machine learning. While much has been written about state formation and nationalism, there is currently no empirically verified theory that shows how nationalism",{"id":218,"funder":7,"programme":8,"title":219,"piName":14,"institution":220,"country":62,"year":13,"amount":221,"abstract":222},"cordis-european-research-council-award-788567","Metal Microstructures in Four Dimensions","DANMARKS TEKNISKE UNIVERSITET","€2,496,519","The goals are:1) to develop a universal laboratory-based 4D X-ray microscope with potentials in the broad field of materials science and beyond;2) to advance metal research by quantifying local microstructural variations using the new 4D tool and by including the effects hereof in the understanding and modelling of industrially relevant metals.Today, high resolution 4D (x,y,z,time) crystallographic characterization of materials is possible only at large international facilities. This is a seriou",{"id":224,"funder":7,"programme":8,"title":225,"piName":14,"institution":226,"country":227,"year":13,"amount":102,"abstract":228},"cordis-european-research-council-award-788433","Fairness and the Moral Mind","NORGES HANDELSHOYSKOLE","NO","The project provides a comprehensive and groundbreaking approach to the analysis of the moral mind and inequality acceptance. The first part of the project will provide a novel study of how the moral ideals of personal responsibility and individual freedom, which are fundamental values in most liberal societies, shape inequality acceptance. It will also provide the first experimental study of how people draw the moral circle, which is at the heart of the most pressing policy challenges facing th",{"id":230,"funder":7,"programme":8,"title":231,"piName":14,"institution":232,"country":125,"year":13,"amount":102,"abstract":233},"cordis-european-research-council-award-788259","Mechanisms of neurotransmitter uptake and storage by synaptic vesicles","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","SummaryIn presynaptic nerve endings, neurotransmitters are stored in synaptic vesicles (SVs) before they are released by exocytosis. SVs contain specific transporters that sequester and concentrate transmitters from cytoplasmic pools. All known vesicular transporters belong to the solute carrier (SLC) superfamily of proteins. They draw the energy for transport from an electrochemical proton gradient created by a V-ATPase across the vesicle membrane. However, despite recent progress it is still l",{"id":235,"funder":7,"programme":8,"title":236,"piName":14,"institution":237,"country":69,"year":13,"amount":238,"abstract":239},"cordis-european-research-council-award-786910","Astrophysical constraints on the identity of the dark matter","UNIVERSITY OF DURHAM","€2,493,439","The identity of the dark matter is a fundamental problem in Physics whose solution will have major implications for cosmology, astronomy and particle physics. There is compelling evidence that the dark matter consists of elementary particles created shortly after the Big Bang, but searches for them in the laboratory and from astrophysical sources have proved inconclusive. The currently favoured candidate is cold dark matter or CDM. This forms the basis of the standard model of cosmology, LCDM, w",{"id":241,"funder":7,"programme":8,"title":242,"piName":14,"institution":243,"country":69,"year":13,"amount":14,"abstract":244},"cordis-european-research-council-award-788405","Molecular mechanisms, evolutionary impacts and applications of prokaryotic epigenetic-targeted immune systems","UNIVERSITY OF BRISTOL","Interactions between bacteria and their viruses (bacteriophages) have led to the evolution of a wide range of bacterial mechanisms to resist viral infection. The exploitation of such systems has produced true revolutions in biotechnology; firstly, the restriction-modification (RM) enzymes for genetic engineering, and secondly, CRISPR-Cas9 for gene editing. This project aims to unravel the mechanisms and consequences of prokaryotic immune systems that target covalently-modified DNA, such as base ",{"id":246,"funder":7,"programme":8,"title":247,"piName":14,"institution":248,"country":249,"year":13,"amount":250,"abstract":251},"cordis-european-research-council-award-742983","Social Media and Traditional Media in China: Political and Economic Effects","STOCKHOLMS UNIVERSITET","SE","€1,716,970","How is political accountability and firm performance in an autocracy affected by media? This project will analyse how economic and political outcomes in China are affected by social and traditional media. It will also use media content to measure factors that are otherwise difficult to observe, such as political networks and the trade-off between political and economic goals in Chinese firms. An explosion of social media use in China has produced an information shock to society and its leaders, ",{"id":253,"funder":7,"programme":8,"title":254,"piName":14,"institution":213,"country":214,"year":13,"amount":102,"abstract":255},"cordis-european-research-council-award-786636","Droplet Photoelectron Imaging","Angle-resolved photoelectron spectroscopy of aerosol droplets (“droplet photoelectron imaging”) is a novel approach to study fundamental aspects of the electron dynamics in liquids and across interfaces. Our recent proof-of-principle studies demonstrate that droplet photoelectron imaging not only complements, but also significantly extends the range of accessible information over established methods. Two aspects are unique to droplets: Firstly, the droplet size can be varied over a wide range fr",{"id":257,"funder":7,"programme":8,"title":258,"piName":14,"institution":259,"country":27,"year":13,"amount":260,"abstract":261},"cordis-european-research-council-award-787041","Dietary Influences on Metastasis: How, When, and Why","FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)","€2,370,625","We have recently identified metastasis-initiating cells (MICs) in several types of tumors (Nature, 2017)1.Intriguingly, MICs: (i) are exclusive in their ability to generate metastases when transplanted; (ii) express thefatty acid channel CD36 and have a unique lipid metabolic signature; (iii) are exquisitely sensitive to thelevels of fat in circulation, thus providing a link between the predisposition of metastasis and dietary fat; (iv)are highly sensitive to CD36 inhibition, which almost comple",{"id":263,"funder":7,"programme":8,"title":264,"piName":14,"institution":265,"country":69,"year":13,"amount":266,"abstract":267},"cordis-european-research-council-award-787264","The Middle East Neolithic Transition: Integrated Community Approaches","THE UNIVERSITY OF READING","€2,499,351","Our world is marked by ‘disruption’, major re-orderings of society through changing circumstances, including abrupt climate change, impacting on social and economic life. What lessons can we learn from the prehistoric past about disruption, and human engagement with it? One of the first global disruptions faced by human societies was the Neolithic transition from mobile forager-hunter to settled farmer-herder in the Epi-Palaeolithic and Early Neolithic periods of the Middle East, 17,000-7000 BCE",{"id":269,"funder":7,"programme":8,"title":270,"piName":14,"institution":271,"country":112,"year":13,"amount":272,"abstract":273},"cordis-european-research-council-award-786572","NOT A writtEn word but graphic symbols. NOTAE: An evidence-based reconstruction of another written world in pragmatic literacy from Late Antiquity to early medieval Europe.","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","€1,479,625","The use of graphic symbols in documentary records from the 4th to the 10th c. has so far received scant attention. ‘Graphic symbols’ are graphic signs (including alphabetical ones) drawn as a visual unit in a written text and representing something other than a word. They therefore broadly cover the semantic spectrum of the Latin ‘notae’ (signs) as opposed to ‘litterae’ (letters of the alphabet). With the gradual introduction of signature and the increasing use of papyrus from the 4th. c., the p",{"id":275,"funder":7,"programme":8,"title":276,"piName":14,"institution":277,"country":214,"year":13,"amount":278,"abstract":279},"cordis-european-research-council-award-788681","DNA Replication: From Physiology to Replication Stress in Human Cancer","UNIVERSITE DE GENEVE","€2,231,378","Replication of the genome is of critical importance for cell proliferation and organismal development. To ensure accurate and complete replication of their genome, eukaryotes have hundreds to thousands of replication origins. In budding yeast, the genomic positions of all the origins are known, as is the order in which they fire. In contrast, in human cells, the mapping of origins is controversial and origin firing may be stochastic and plastic. Furthermore, while normal cells replicate their ge",{"id":281,"funder":7,"programme":8,"title":282,"piName":14,"institution":283,"country":125,"year":13,"amount":102,"abstract":284},"cordis-european-research-council-award-788921","Cellular innovation driving nervous system evolution","EUROPEAN MOLECULAR BIOLOGY LABORATORY","Nervous system evolution involved multiple cellular innovations, enabling fast synaptic transmission,novel sensory modalities, and complex forms of neural connectivity. These innovations weredistributed to an ever-increasing number of neural cell types, each specified and maintained by thecombinatorial activity of transcription factors. When, where, and how did this complexity arise?This proposal aims at resolving the history of cell type diversification that led to this complexity, fromthe birt",{"id":286,"funder":7,"programme":8,"title":287,"piName":14,"institution":288,"country":69,"year":13,"amount":289,"abstract":290},"cordis-european-research-council-award-743035","Ecological Language: A multimodal approach to language and the brain","UNIVERSITY COLLEGE LONDON","€2,243,584","The human brain has evolved the ability to support communication in complex and dynamic environments. In such environments, language is learned, and mostly used in face-to-face contexts in which processing and learning is based on multiple cues: linguistic (such as lexical, syntactic), but also discourse, prosody, face and hands (gestures). Yet, our understanding of how language is learnt and processed, and its associated neural circuitry, comes almost exclusively from reductionist approaches in",{"id":292,"funder":7,"programme":8,"title":293,"piName":14,"institution":243,"country":69,"year":13,"amount":294,"abstract":295},"cordis-european-research-council-award-788203","Innovation and opportunity in the evolution of life","€2,482,225","The aim is to produce a complete evolutionary tree of tetrapods and use this to explore two core questions in macroevolution: the balance between innovation and external processes in driving the evolution of life; and, identifying the best model for morphological evolution. Biodiversity today is unbalanced, with a small number of highly successful groups, like birds and beetles, and many others of equal antiquity but with far fewer species. Why are those groups so successful – was it chance or d",{"id":297,"funder":7,"programme":8,"title":298,"piName":14,"institution":299,"country":125,"year":13,"amount":300,"abstract":301},"cordis-european-research-council-award-789256","Stepping Up mRNA Mutanome Immunotherapy","TRON - TRANSLATIONALE ONKOLOGIE ANDER UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ GEMEINNUTZIGE GMBH","€2,482,500","Immunotherapy is expected to fundamentally change the treatment of cancer patients. Personalized vaccines elicitingimmune responses against individual cancer mutations have moved into the spotlight. We have pioneered the field andmoved ´cancer mutanome vaccines´ from a mere vision into a disruptive medical concept compatible with currentstandards of drug development and health care practice. Solving key scientific and technological challenges and buildingon extensive preclinical studies, we show",{"id":303,"funder":7,"programme":8,"title":304,"piName":14,"institution":305,"country":249,"year":13,"amount":102,"abstract":306},"cordis-european-research-council-award-741366","Treating mitochondrial disease caused by pathogenic mtDNA mutations","KAROLINSKA INSTITUTET","This proposal describes a series of powerful experimental strategies to develop a completely novel treatment for mtDNA mutation disease based on identifying unknown mechanisms controlling mtDNA replication. Several hundred different mtDNA mutations affect tRNA genes and impair mitochondrial translation leading to human disease. There is typically heteroplasmy with a mixture of wild-type and mutated mtDNA, and the mutations are acting in a “recessive” (loss of function) way. Very high levels of m",{"id":308,"funder":7,"programme":8,"title":309,"piName":14,"institution":310,"country":27,"year":13,"amount":311,"abstract":312},"cordis-european-research-council-award-789055","Expanding the genetic etiological and diagnostic spectrum of monogenic diabetes mellitus","FUNDACIO CENTRE DE REGULACIO GENOMICA","€2,243,746","Whole genome sequencing is quickly becoming a routine clinical instrument. However, our ability to decipher DNA variants is still largely limited to protein-coding exons, which comprise 1% of the genome. Most known Mendelian mutations are in exons, yet genetic testing still fails to show causal coding mutations in more than 50% of well-characterized Mendelian disorders. This defines a pressing need to interpret noncoding genome sequences, and to establish the role of noncoding mutations in Mende",{"id":314,"funder":7,"programme":8,"title":315,"piName":14,"institution":232,"country":125,"year":13,"amount":316,"abstract":317},"cordis-european-research-council-award-788301","Harnessing the Molecules of Medicinal Plants","€2,499,999","Plants, as sessile organisms, synthesize complex molecules for defense and signaling. Humans have long exploited the potent medicinal activities of these plant natural products: artemisinin from sweet wormwood is used to cure malaria, vincristine from Madagascar periwinkle is used to treat cancer, and morphine from poppy alleviates pain. Synthetic biology approaches are being used with increasing success to overproduce these expensive molecules, which are often present at low levels in the plant",{"id":319,"funder":7,"programme":8,"title":320,"piName":14,"institution":321,"country":322,"year":13,"amount":323,"abstract":324},"cordis-european-research-council-award-742231","Tracking and evaluating social relations and potential partners in infancy","CEU GMBH","AT","€2,498,748","In order to navigate the social world, children must understand how social interactions unfold in their society. While many recent studies have investigated how children evaluate the roles that people play in everyday interactions and what inferences they draw from their observations, to date there is no unifying account for the conceptual repertoire and computational mechanisms used by infants to analyse their social environment. Taking a new theoretical perspective on this topic, we plan to st",{"id":326,"funder":7,"programme":8,"title":327,"piName":14,"institution":328,"country":322,"year":13,"amount":329,"abstract":330},"cordis-european-research-council-award-789037","Elucidating the causes and consequences of the global pattern of epigenetic variation in Arabidopsis thaliana","GREGOR MENDEL INSTITUT FUR MOLEKULARE PFLANZENBIOLOGIE GMBH","€2,498,468","Epigenetics continues to fascinate, especially the notion that it blurs the line between “nature and nurture” and could make Lamarckian adaptation via the inheritance of acquired characteristics possible. That this is in principle possible is clear: in the model plant Arabidopsis thaliana (Thale cress), experimentally induced DNA methylation variation can be inherited and affect important traits. The question is whether this is important in nature. Recent studies of A. thaliana have revealed a p",{"id":332,"funder":7,"programme":8,"title":333,"piName":14,"institution":334,"country":69,"year":13,"amount":335,"abstract":336},"cordis-european-research-council-award-789108","Engineering with Logic and Verification: Mathematically Rigorous Engineering for Safe and Secure Computer Systems","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€2,473,844","Computer systems have become critical to modern society, but they are pervasively subject to security flaws and malicious attacks, with large-scale exposures of confidential data, denial-of-service and ransom attacks, and the threat of nation-state attackers: they are trusted, but are far from trustworthy. This is especially important for the major pan-industry components of our information infrastructure: processors, programming languages, operating systems, etc.The basic problem is that conven",{"id":338,"funder":7,"programme":8,"title":339,"piName":14,"institution":340,"country":125,"year":13,"amount":341,"abstract":342},"cordis-european-research-council-award-787576","Artificial Intelligence for Air Quality","FORSCHUNGSZENTRUM JULICH GMBH","€2,498,761","The IntelliAQ project will develop novel approaches for the analysis and synthesis of global air quality data based on deep neural networks. The foundation of this project is the world’s largest collection of surface air quality measurements, which was recently assembled by the principal investigator and plays a pivotal role in the ongoing first comprehensive Tropospheric Ozone Assessment Report (TOAR). This database will be complemented with data from the world’s leading effort to collect globa",{"id":344,"funder":7,"programme":8,"title":345,"piName":14,"institution":346,"country":27,"year":13,"amount":347,"abstract":348},"cordis-european-research-council-award-788143","Breaking the limits in glycan recognition by NMR","ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS","€2,499,980","Carbohydrates (glycans, sugars) play key roles in virtually all biological events. Given their chemical complexity, understanding their roles in nature requires a multidisciplinary approach. Research in the field is growing, since advances in the area could be part of the solution to many health issues. However, we lack full knowledge on the role of most glycan-mediated events especially at the resolution required from a chemical perspective to manipulate them and create new probes and eventuall",{"id":350,"funder":7,"programme":8,"title":351,"piName":14,"institution":243,"country":69,"year":13,"amount":352,"abstract":353},"cordis-european-research-council-award-788563","Modern Marronage? The Pursuit and Practice of Freedom in the Contemporary World","€1,847,596","Contemporary antislavery campaigners invoke the history of Atlantic World slavery to highlight the plight of 48 million people today living in exceptionally harsh circumstances, described as ‘modern slavery’. Yet in a world where many are oppressed and exploited, the lines between ‘modern slavery’ and other forms of drudgery, exclusion, and domination, are not easily drawn. Critics argue that the dominant discourse of ‘modern slavery’ relies upon a highly selective vision of injustice and suffer",{"id":355,"funder":7,"programme":8,"title":356,"piName":14,"institution":357,"country":69,"year":13,"amount":102,"abstract":358},"cordis-european-research-council-award-786674","Steady-state and demand-driven dendritic cell generation","THE FRANCIS CRICK INSTITUTE LIMITED","Classical dendritic cells (cDCs) are leucocytes that play a key role in innate immunity as well as the initiation and regulation of T cell responses. cDCpoiesis starts with commitment of a bone marrow (BM) haematopoietic progenitor, known as the classical DC precursor (CDP), to the cDC lineage. CDPs then give rise to pre-cDCs that exit the BM via the blood and seed tissues to give rise to the two major types of fully-differentiated cDCs, the cDC1 and cDC2 subsets. The key parameters of cDCpoiesi",{"id":360,"funder":7,"programme":8,"title":361,"piName":14,"institution":357,"country":69,"year":13,"amount":362,"abstract":363},"cordis-european-research-council-award-742138","The molecular and cellular logic of vertebrate neural development","€2,357,000","A central problem in biology and key to realising the potential of regenerative medicine is understanding the mechanisms that produce and organize cells in the complex tissues of an embryo. In broad terms, initially uncommitted progenitors acquire their fate in response to signals that control transcriptional programmes. These programmes drive cells through spatial and temporal successions of states that gradually refine cell identity. How these states are established and cell fate decisions imp",{"id":365,"funder":7,"programme":8,"title":366,"piName":14,"institution":367,"country":322,"year":13,"amount":368,"abstract":369},"cordis-european-research-council-award-786295","Enabling Precision Immuno-oncology in Colorectal cancer","MEDIZINISCHE UNIVERSITAT INNSBRUCK","€2,460,500","Immunotherapy with checkpoints blockers is transforming the treatment of advanced cancers. Colorectal cancer (CRC), a cancer with 1.4 million new cases diagnosed annually worldwide, is refractory to immunotherapy (with the exception of a minority of tumors with microsatellite instability). This is somehow paradoxical as CRC is a cancer for which we have shown that it is under immunological control and that tumor infiltrating lymphocytes represent a strong independent predictor of survival. Thus,",{"id":371,"funder":7,"programme":8,"title":372,"piName":14,"institution":373,"country":249,"year":13,"amount":102,"abstract":374},"cordis-european-research-council-award-787516","Study of the Planetary Human-Environment Relationship: The Rise of Global Environmental Governance","KUNGLIGA TEKNISKA HOEGSKOLAN","SPHERE is a historical study of humanity’s relation to planetary conditions and constraints and how it has become understood as a governance issue. The key argument is that Global Environmental Governance (GEG), which has arisen in response to this issue, is inseparable from the rise of a planetary Earth systems science and a knowledge-informed understanding of global change that has affected broad communities of practice. The overarching objective is to provide a fundamentally new perspective o",{"id":376,"funder":7,"programme":8,"title":377,"piName":14,"institution":378,"country":125,"year":13,"amount":102,"abstract":379},"cordis-european-research-council-award-787826","Necroptosis in immunity, inflammation and autoimmunity induced by nucleic acid sensors","UNIVERSITAT ZU KOLN","Cell death plays an important role in host defence particularly in response to virus infections, but also contributes to tissue damage, inflammation and disease. Therefore, dissecting the mechanisms regulating cell death and its function in immunity and inflammation will be important for the better understanding of the pathogenesis of infectious and inflammatory diseases. Necroptosis is a recently characterised type of regulated necrotic cell death induced by RIPK3 and its substrate MLKL. Necrop",{"id":381,"funder":7,"programme":8,"title":382,"piName":14,"institution":383,"country":322,"year":13,"amount":384,"abstract":385},"cordis-european-research-council-award-788183","Alpha Shape Theory Extended","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","€1,678,432","Alpha shapes were invented in the early 80s of last century, and their implementation in three dimensions in the early 90s was at the forefront of the exact arithmetic paradigm that enabled fast and correct geometric software. In the late 90s, alpha shapes motivated the development of the wrap algorithm for surface reconstruction, and of persistent homology, which was the starting point of rapidly expanding interest in topological algorithms aimed at data analysis questions. We now see alpha sha",{"id":387,"funder":7,"programme":8,"title":388,"piName":14,"institution":389,"country":21,"year":13,"amount":390,"abstract":391},"cordis-european-research-council-award-787836","Neuroplasticity and the Musical Experience","ECOLE NORMALE SUPERIEURE","€2,495,938","Experiencing music as a listener, performer, or a composer is an active process that engages perceptual and cognitive faculties, endowing the experience with memories, joy, and emotion. Through this active auditory engagement, humans analyze and comprehend complex musical scenes by invoking its cultural norms, segregating sound mixtures, and marshaling expectations and anticipation. These remarkable feats are beyond our understanding and far exceed the capabilities of the most sophisticated musi",{"id":393,"funder":7,"programme":8,"title":394,"piName":14,"institution":395,"country":27,"year":13,"amount":396,"abstract":397},"cordis-european-research-council-award-742989","Moments in Time in Immersive Virtual Environments","UNIVERSITAT DE BARCELONA","€2,199,318","This project investigates how virtual reality (VR) can be used to live through an historical event so that participants perceive themselves to be there (Place Illusion) and take the events that are happening as real (Plausibility). To provide an application focus the research will be constructed around recreating a famous rock concert from the 1980s. The specific elements of the research involve an Agent Based Model (ABM) that populates the environment with thousands of virtual characters with t",{"id":399,"funder":7,"programme":8,"title":400,"piName":14,"institution":367,"country":322,"year":13,"amount":401,"abstract":402},"cordis-european-research-council-award-787171","The PIDDosome in Centrosome and Ploidy-Surveillance","€2,355,000","Tight control of the number of chromosome sets in a cell (ploidy) is fundamental for normal development and organismal health. Most cells in our body are diploid, yet, some cells, including cardiomyocytes or hepatocytes require a balanced increase in ploidy for proper function. Polyploidization is accompanied by an accumulation of centrosomes, structures needed for nucleating the mitotic spindle and ciliogenesis. Extra centrosomes, however, promote aneuploidy in proliferating cells by causing er",{"id":404,"funder":7,"programme":8,"title":405,"piName":14,"institution":406,"country":141,"year":13,"amount":407,"abstract":408},"cordis-european-research-council-award-741884","Open Philology: The Composition of Buddhist Scriptures","UNIVERSITEIT LEIDEN","€2,498,296","Buddhist sūtras are fundamental sources for understanding the beliefs that once dominated, and largely continue to dominate, Asian societies. But classical philological approaches to these texts, assuming an Ur-text and linear development, misrepresent their nature and obscure their history. Like oral literature the sūtras are authorless and textually fluid, their content formulaic and modular, and the situation complicated by their huge volume and the linguistic diversity of their extant versio",{"id":410,"funder":7,"programme":8,"title":411,"piName":14,"institution":68,"country":69,"year":13,"amount":412,"abstract":413},"cordis-european-research-council-award-787342","Documenting Multiculturalism: coexistence, law and multiculturalism in the administrative and legal documents of Norman and Hohenstaufen Sicily, c.1060-c.1266","€2,467,965","Documenting Multiculturalism will investigate comprehensively and systematically the coexistence of the diverse confessional, ethnic and linguistic communities of the island of Sicily under its Norman and Hohenstaufen rulers — Arabic-speaking Muslims and Jews, Greek Christians, and Latin Christians. It will investigate: the legal foundations upon which the coexistence of the subject communities rested; the nature, extent and results of cultural, linguistic and social interactions between them; a",{"id":415,"funder":7,"programme":8,"title":416,"piName":14,"institution":68,"country":69,"year":13,"amount":417,"abstract":418},"cordis-european-research-council-award-788223","Spanning TeV to GeV scales for collider discoveries and measurements","€2,339,381","Over the coming years, the Large Hadron Collider (LHC) will search for new physics at ever higher energies, firmly establish many facets of the Standard Model that relate to the Higgs boson, and carry out a broad range of precision measurements. A tool that is central to this endeavour is the parton shower. Parton showers are immensely flexible tools, which simulate the strong-interaction physics that occurs between the TeV energy scales that the LHC was designed to probe, and the GeV mass scale",{"id":420,"funder":7,"programme":8,"title":421,"piName":14,"institution":68,"country":69,"year":13,"amount":102,"abstract":422},"cordis-european-research-council-award-788814","Emergence from Quantum Frustration and Topology","Highly-correlated many-body quantum states often emerge from correlations between strongly interacting electrons. The proposed research will experimentally explore emergent properties of quantum materials in the presence of strong correlations and spin-orbit coupling, when the spin and orbital angular momentum of electrons are strongly entangled. This is a largely experimentally unexplored regime where theoretical guidance suggests a fertile ground to potentially discover completely new types of",{"id":424,"funder":7,"programme":8,"title":425,"piName":14,"institution":68,"country":69,"year":13,"amount":426,"abstract":427},"cordis-european-research-council-award-787504","The European Fiscal-Military System 1530-1870","€2,499,853","FMSystem transforms the conventional narrative of the violent rise of the European states system by revealing how belligerent competition also involved cooperation. States were not autarkic actors. Their emergence was co-dependent and entailed developing ways to obtain war-making resources from beyond their jurisdictions. This project adds a new conceptual framework to understand this process and broadens the research focus to include the role of non-state actors in minor as well as major countr",{"id":429,"funder":7,"programme":8,"title":430,"piName":14,"institution":68,"country":69,"year":13,"amount":431,"abstract":432},"cordis-european-research-council-award-787185","The Analytic Conformal Bootstrap","€2,171,483","The aim of the present proposal is to establish a research team developing and exploiting innovative techniques to study conformal field theories (CFT) analytically. Our approach does not rely on a Lagrangian description but on symmetries and consistency conditions. As such it applies to any CFT, offering a unified framework to study generic CFTs analytically. The initial implementation of this program has already led to striking new results and insights for both Lagrangian and non-Lagrangian CF",{"id":434,"funder":7,"programme":8,"title":435,"piName":14,"institution":288,"country":69,"year":13,"amount":436,"abstract":437},"cordis-european-research-council-award-789270","The Roots of Responsibility: Metaphysics, Humanity, and Society","€2,114,516","Philosophical research on responsibility today stems from early modern debates about causal necessity and freedom of the will, and ultimately from the Stoic problem of reconciling ethics with physics.  It is therefore mainly focused on scepticism about the existence of free will and on the question whether moral responsibility is compatible with physical determinism.  The main premises of this project are that this focus is too narrow, and that the traditional problems can only be solved with a ",{"id":439,"funder":7,"programme":8,"title":440,"piName":14,"institution":68,"country":69,"year":13,"amount":441,"abstract":442},"cordis-european-research-council-award-788144","The Complexity Revolution: Exploiting Unconventional Order in Next-Generation Materials Design","€3,362,635","The fundamental objective of the research described in this proposal is to lay the foundations for understanding how structural complexity can give rise to materials properties inaccessible to structurally-simple states. The long-term vision is a paradigm shift in the way we as chemists design materials—the “Complexity Revolution”—where we move to thinking beyond the unit cell and harness unconventional order to generate emergent states with entirely novel behaviour. The key methodologies of the",{"id":444,"funder":7,"programme":8,"title":445,"piName":14,"institution":446,"country":27,"year":13,"amount":447,"abstract":448},"cordis-european-research-council-award-788250","Non-local dynamics in incompressible fluids","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","€1,779,369","The goal of this project is to pursue new methods in the mathematical analysis of non-local and non-linearpartial differential equations. For this purpose we present several physical scenarios of interest in the contextof incompressible fluids, from a mathematical point of view as well as for its applications: both from thestandpoint of global well-posedness, existence and uniqueness of weak solutions and as candidates for blowup.The equations we consider are the incompressible Euler equations, ",{"id":450,"funder":7,"programme":8,"title":451,"piName":14,"institution":452,"country":27,"year":13,"amount":453,"abstract":454},"cordis-european-research-council-award-785994","Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development","FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA","€2,499,992","Air pollution is the main urban-related environmental hazard. It appears to affect brain development, although current evidence is inadequate given the lack of studies during the most vulnerable stages of brain development and the lack of brain anatomical structure and regional connectivity data underlying these effects. Of particular interest is the prenatal period, when brain structures are forming and growing, and when the effect of in utero exposure to environmental factors may cause permane",{"id":456,"funder":7,"programme":8,"title":457,"piName":14,"institution":446,"country":27,"year":13,"amount":458,"abstract":459},"cordis-european-research-council-award-741930","CLOTH manIpulation Learning from DEmonstrations","€2,499,149","Textile objects pervade human environments and their versatile manipulation by robots would open up a whole range ofpossibilities, from increasing the autonomy of elderly and disabled people, housekeeping and hospital logistics, to novelautomation in the clothing internet business and upholstered product manufacturing. Although efficient procedures exist forthe robotic handling of rigid objects and the virtual rendering of deformable objects, cloth manipulation in the real world hasproven elusiv",{"id":461,"funder":7,"programme":8,"title":462,"piName":14,"institution":463,"country":27,"year":13,"amount":464,"abstract":465},"cordis-european-research-council-award-742705","Transnational Gangs as Agents of Mediation: Experiences of Conflict Resolution in Street Youth Organizations in Southern Europe, North Africa and the Americas","UNIVERSIDAD POMPEU FABRA","€2,343,249","TRANSGANG aims to develop a renewed model for the analysis of transnational youth gangs in the global age, in dialogue with two classics of urban ethnography, published nearly a century ago: The Gang, by F.M. Thrasher (1926) and The Polish Peasant in Europe and America, by W. I. Thomas and F. Znaniecki (1918-1920). To do this, the project will start by a systematic review of the historical literature on youth gangs, which will try to overcome the north-american-centrism, dominant in contemporary",{"id":467,"funder":7,"programme":8,"title":468,"piName":14,"institution":469,"country":27,"year":13,"amount":470,"abstract":471},"cordis-european-research-council-award-788781","Towards the detection of the axion with the International Axion Observatory","UNIVERSIDAD DE ZARAGOZA","€3,106,875","The nature of the Dark Universe is an outstanding question in modern science, and is connected with our understanding of the reality at the most fundamental level. Despite the enormous success of the Standard Model (SM) of particle physics, a number of shortcomings of the theory and the fact that it does not account for the Dark Matter and Energy, prompt theorists to propose possible hypothetical extensions. Some of these extensions predict the existence of very-light and very-weakly-coupled axi",{"id":473,"funder":7,"programme":8,"title":474,"piName":14,"institution":475,"country":21,"year":13,"amount":14,"abstract":476},"cordis-european-research-council-award-786854","Foundations of Geometric Statistics and Their Application in the Life Sciences","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","Invariance under gauge transformation groups provides the natural structure explaining the laws of physics. In life sciences, new mathematical tools are needed to estimate approximate invariance and establish general but approximate laws. Rephrasing Poincaré: a geometry cannot be more true than another, it may just be more convenient, and statisticians must find the most convenient one for their data. At the crossing of geometry and statistics, G-Statistics aims at establishing the mathematical ",{"id":478,"funder":7,"programme":8,"title":479,"piName":14,"institution":475,"country":21,"year":13,"amount":480,"abstract":481},"cordis-european-research-council-award-788065","A New Foundation for Computer Graphics with Inherent Uncertainty","€2,497,161","The use of Computer Graphics (CG) is constantly expanding, e.g., in Virtual and Augmented Reality, requiring realistic interactive renderings of complex virtual environments at a much wider scale than available today. CG has many limitations we must overcome to satisfy these demands. High-quality accurate rendering needs expensive simulation, while fast approximate rendering algorithms have no guarantee on accuracy; both need manually-designed expensive-to-create content. Capture (e.g., reconstr",{"id":483,"funder":7,"programme":8,"title":484,"piName":14,"institution":80,"country":21,"year":13,"amount":485,"abstract":486},"cordis-european-research-council-award-787300","Decoding at systems-level the crosstalk between the T cell antigen receptor, the CD28 costimulator and the PD-1 coinhibitor under physiological and pathological conditions.","€2,000,000","Although the T cell antigen receptor (TCR) occupies a central place in T cell physiology, it does not work in isolation and the signals it triggers are tuned by receptors that convey positive (costimulators) and negative (coinhibitors) informations. We lack a satisfying comprehension of the way T cells integrate such multiple inputs to make informed decisions. The proteomics-based methodology we developed around the TCR places us in a favorable situation to decode at systems-level the crosstalk ",{"id":488,"funder":7,"programme":8,"title":489,"piName":14,"institution":80,"country":21,"year":13,"amount":490,"abstract":491},"cordis-european-research-council-award-788308","Interplay between genetic control and self-organization during embryo morphogenesis","€2,862,571","Morphogenesis seeks to understand how information and mechanics emerge from molecular interactions and how they are regulated in space and time. Two parallel legacies are now intertwined: the conceptual framework of developmental patterning that explains how cells acquire positional information during development and control cell behaviors, and the description of biological processes in physical terms. The current framework explains how genetic and biochemical information controls cellular mecha",{"id":493,"funder":7,"programme":8,"title":494,"piName":14,"institution":80,"country":21,"year":13,"amount":495,"abstract":496},"cordis-european-research-council-award-788137","Unveiling the Hidden: A Search for Light Dark Matter with CCDs","€3,349,563","Dark matter (DM) is a ubiquitous yet invisible presence in our universe. It dictated how galaxies formed in the first place, and now moves stars around them at puzzling speeds. The DM mass in the universe is known to be five times that of ordinary matter; yet its true nature remains elusive. Weakly interacting massive particles (WIMPs), relics from the early universe, are a compelling explanation chased by sensitive experiments in deep underground laboratories. However, searches for heavy WIMPs ",{"id":498,"funder":7,"programme":8,"title":499,"piName":14,"institution":500,"country":69,"year":13,"amount":501,"abstract":502},"cordis-european-research-council-award-786494","A Gendered International Law of Peace","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","€1,999,705","The ambitious aim of this cutting-edge project is to develop the theoretical foundations for a ‘gendered international law of peace’. In so doing, the project will critically engage with the UN Security Council’s Women, Peace and Security (WPS) agenda, first set out in resolution 1325, 2000. By 2015, the Security Council had adopted seven further resolutions, which together provide a political agenda for change in international relations. Notwithstanding the body of research that has been genera",{"id":504,"funder":7,"programme":8,"title":505,"piName":14,"institution":506,"country":69,"year":13,"amount":507,"abstract":508},"cordis-european-research-council-award-786398","ADVANCED NANOMEMBRANES FOR EXACT POLYMER PRODUCTION","QUEEN MARY UNIVERSITY OF LONDON","€2,499,814","The production of synthetic polymers with precisely defined monomer sequences – exact polymers, which I call “exactymers” – is highly challenging. Iterative synthesis, in which specific monomers are added one-at-a-time to the end of a growing polymer chain, affords exquisite control over the final sequence, but requires accurate purification of the growing polymer with each and every cycle. EXACTYMER will create new super-stable, ultra-selective nanomembranes, with high permeances, enabling rapi",{"id":510,"funder":7,"programme":8,"title":511,"piName":14,"institution":512,"country":69,"year":13,"amount":316,"abstract":513},"cordis-european-research-council-award-788575","Mechanisms of adverse effects of Beta-Agonists in Asthma","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","Beta2 agonists (B2as) such as the short acting salbutamol, used to relieve acute wheeze, and the long acting salmeterol used to control asthma with inhaled steroids (ICS), are almost universally used in asthma. However, there is significant concern over morbidity and mortality related to adverse effects, particularly when used without ICS, and\u002For in excess at exacerbation (mostly caused by rhinovirus [RV] infection). The mechanisms of adverse effects are not understood. This proposal will rock t",{"id":515,"funder":7,"programme":8,"title":516,"piName":14,"institution":512,"country":69,"year":13,"amount":517,"abstract":518},"cordis-european-research-council-award-787203","Re-inventing Ecosystem And Land-surface Models","€2,499,615","Terrestrial ecosystems respond to changes in climate and the atmospheric environment, which they in turn help to regulate. As global change has become an international concern, high expectations have been laid on Earth system models with embedded ecosystem and biophysical land-surface components to deliver reliable, quantitative predictions of large-scale changes in ecosystems and their feedbacks to the climate system. But the lack of established quantitative theory for many fundamental processe",{"id":520,"funder":7,"programme":8,"title":521,"piName":14,"institution":512,"country":69,"year":13,"amount":14,"abstract":522},"cordis-european-research-council-award-788529","Empirical evidence on the impact of the labour market on the production of healthcare and health","What determines the quality of public services? How do shocks to the economy affect the delivery of public services? Why is there such variation in the efficiency of public service providers and how does this affect those who use their services? My aim is to make a fundamental contribution to our understanding of the labour supply behaviour of public service providers and the impact of their behaviour on the quality and distribution of critical outcomes. To achieve this I will primarily focus on",{"id":524,"funder":7,"programme":8,"title":525,"piName":14,"institution":512,"country":69,"year":13,"amount":526,"abstract":527},"cordis-european-research-council-award-787470","Sex differences in intestinal plasticity","€2,485,217","Sex differences in intestinal plasticityMales and females often differ in their physiology and disease susceptibility. Sex hormones play key roles in sculpting and maintaining such sex differences, but increasing evidence points to a contribution of cell-intrinsic mechanisms. We are only beginning to understand the molecular mediators of these intrinsic mechanisms, and little is known about the organs where they function and their effects at the whole-organism level. Our work in flies recently r",{"id":529,"funder":7,"programme":8,"title":530,"piName":14,"institution":80,"country":21,"year":13,"amount":14,"abstract":531},"cordis-european-research-council-award-786304","Fiber Optic Cable Use for Seafloor studies of earthquake hazard and deformation","Two-thirds of the Earth’s surface is covered by water and thus largely inaccessible to modern networks of seismological instruments. The FOCUS project is poised to revolutionize seismic monitoring of the seafloor through a novel use of fiber optic cables to improve hazard assessment and increase early warning capability. Laser reflectometry using BOTDR, commonly used for structural health monitoring of large-scale engineering structures (e.g. - bridges, dams, pipelines, etc.), can measure very s",{"id":533,"funder":7,"programme":8,"title":534,"piName":14,"institution":80,"country":21,"year":13,"amount":535,"abstract":536},"cordis-european-research-council-award-785911","Active nanofluidics towards ionic machines","€2,431,000","Filtering and water purification rely traditionnally on the concept of passive sieving across properly decorated nanopores. Such basic separation principle contrasts with the highly advanced membrane processes existing in Nature, which harness the full subtleties of active transport across channels. This involves advanced functions like ionic pumps, ultra-high selective channels, or voltage-gated nanopores, which all play a key role in many vital needs and neuronal functions.The Shadoks project ",{"id":538,"funder":7,"programme":8,"title":539,"piName":14,"institution":80,"country":21,"year":13,"amount":540,"abstract":541},"cordis-european-research-council-award-742095","Star-Planet-Inner Disk Interactions (SPIDI): unveiling the formation and evolution of inner planetary systems","€2,362,230","With more than 2,000 confirmed exoplanets discovered to date, and about 4,000 additional candidates, it is now widely accepted that nearly every star in the Galaxy hosts a planetary system. These systems greatly differs from our Solar System: a vast majority of exoplanets revolves at a distance less than the Earth’s orbit (1 astronomical unit, 1 AU), and many orbit very close to their parent star indeed (\u003C0.1 AU). These inner planets, with an orbital period less than 100 days, are quite diverse,",{"id":543,"funder":7,"programme":8,"title":544,"piName":14,"institution":80,"country":21,"year":13,"amount":545,"abstract":546},"cordis-european-research-council-award-787304","Smooth dynamics via Operators, with Singularities","€1,830,070","The ergodic theory of smooth dynamical systems enjoying some form of hyperbolicity has undergone important progress since the beginning of the twenty first century, in part due to the development of a new technical tool: anisotropic Banach or Hilbert spaces, on which transfer operators have good spectral properties. Very recently, such tools have yielded exponential mixing for dispersing (Sinai) billiard flows (i.e. the 2D periodic Lorentz gas), which are the archetypal smooth systems with singu",{"id":548,"funder":7,"programme":8,"title":549,"piName":14,"institution":80,"country":21,"year":13,"amount":550,"abstract":551},"cordis-european-research-council-award-742345","Cryogenic Rare-event Observatory with Surface Sensitivity","€3,146,598","CROSS will set the grounds for large-scale experiments searching for neutrinoless double beta decay with zero background at an exposure scale of ~1 tonne x year and with very high energy resolution – about 1.5‰ – in the region of interest. These features will enable searching for lepton number violation with unprecedented sensitivity, penetrating in prospect the direct-ordering region of the neutrino masses. CROSS will be based on arrays of TeO2 and Li2MoO4 bolometers enriched in the isotopes of",{"id":553,"funder":7,"programme":8,"title":554,"piName":14,"institution":140,"country":141,"year":13,"amount":555,"abstract":556},"cordis-european-research-council-award-789267","Eukaryotic DNA replication: a single-molecule approach to the study of yeast replication on chromatin","€2,388,100","DNA replication is essential to cellular function. During a lifetime, each of us synthesizes a light-year’s length of DNA, but this process is so robust that few of us will develop cancer. In eukaryotes, DNA is packed into chromatin, a hierarchical DNA-protein assembly of which the nucleosome forms the basic unit. Chromatin replication convolves DNA replication with the duplication and reassembly of all DNA-associated proteins. Understanding the coupling between these processes has fundamental i",{"id":558,"funder":7,"programme":8,"title":559,"piName":14,"institution":265,"country":69,"year":13,"amount":560,"abstract":561},"cordis-european-research-council-award-786427","Transient climate change in the coupled atmosphere--ocean system","€2,127,711","The magnitude and impacts of many aspects of projected climate change due to anthropogenic emissions of greenhouse gases are expected to be greater for larger global mean surface temperature change. Although climate models have hugely improved, knowledge has grown and confidence increased, the climate feedback parameter, which determines the amount of global warming that results at equilibrium for a given radiative forcing (the heating due to greenhouse gases and other agents) is still very unce",{"id":563,"funder":7,"programme":8,"title":564,"piName":14,"institution":147,"country":125,"year":13,"amount":565,"abstract":566},"cordis-european-research-council-award-786762","Animals in the Philosophy of the Islamic World","€2,343,661","Are animals conscious? Can they think or feel emotions? What makes them different from humans on the one hand and plants on the other? And how should we treat them?This project will bring to light a rich body of texts written in the Islamic world, which address just such questions about the value and nature of animals. Contrary to common assumptions, such questions were taken seriously in pre-modern thought. Scholars have explored ancient Greek and Indian discussions of animals, but little atten",{"id":568,"funder":7,"programme":8,"title":569,"piName":14,"institution":570,"country":322,"year":13,"amount":571,"abstract":572},"cordis-european-research-council-award-742046","Understanding the evolution of regeneration-permissive gene expression and positional memory in Axolotl limb regeneration","FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH","€2,325,659","Molecular studies of development in diverse animal models have revealed the remarkably conserved set of morphogens governing growth and patterning of body axes and organ fields.  Equally astounding is the diversity of form and function arising from the implementation of these morphogens. The systematic analysis of well-defined traits in closely related species has revealed how changes in gene regulatory sequences and their trans-acting factors have yielded diversity.  An important future challen",{"id":574,"funder":7,"programme":8,"title":575,"piName":14,"institution":576,"country":322,"year":13,"amount":577,"abstract":578},"cordis-european-research-council-award-741888","Chronic Systemic Inflammation: Functional organ cross-talk in inflammatory disease and cancer","MEDIZINISCHE UNIVERSITAET WIEN","€2,499,875","Chronic Systemic Inflammation (CSI) resulting from systemic release of inflammatory cytokines and activation of the immune system is responsible for the progression of several debilitating diseases, such as Psoriasis, Arthritis and Cancer. Initially localised diseases can result in CSI with subsequent systemic spread to distant organs, a key patho-physiological phase responsible for major morbidity and even mortality. Despite the importance of CSI, a complete understanding of the molecular mecha",{"id":580,"funder":7,"programme":8,"title":581,"piName":14,"institution":582,"country":322,"year":13,"amount":583,"abstract":584},"cordis-european-research-council-award-787522","Ancient Music Beyond Hellenisation","OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN","€775,959","From medieval times, Arabic as well as European music was analysed in terms that were inherited from Classical Antiquity and had thus developed in a very different music culture. In spite of recent breakthroughs in the understanding of the latter, whose technicalities we access not only through texts and iconography, but also through instrument finds and surviving notated melodies, its relation to music traditions known from later periods and different places is almost uncharted territory.The pr",{"id":586,"funder":7,"programme":8,"title":587,"piName":14,"institution":588,"country":125,"year":13,"amount":589,"abstract":590},"cordis-european-research-council-award-787914","Formal Reasoning About Probabilistic Programs: Breaking New Ground for Automation","RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN","€2,491,250","Probabilistic programs describe recipes on how to infer statistical conclusions about data from a complex mixture of uncertain data and real-world observations. They can represent probabilistic graphical models far beyond the capabilities of Bayesian networks and are expected to have a major impact on machine intelligence.Probabilistic programs are ubiquitous. They steer autonomous robots and self-driving cars, are key to describe security mechanisms, naturally code up randomised algorithms for ",{"id":592,"funder":7,"programme":8,"title":593,"piName":14,"institution":594,"country":595,"year":13,"amount":596,"abstract":597},"cordis-european-research-council-award-788489","Bioproducts Engineered from Lignocelluloses: from plants and upcycling to next generation materials","AALTO KORKEAKOULUSAATIO SR","FI","€2,486,182","BioELCell will deliver ground-breaking approaches to create next material generation based on renewable resources, mainly cellulose and lignin micro- and nano-particles (MNC, MNL). Our action will disassemble and re-engineer these plant-based polymers into functional materials that will respond to the demands of the bioeconomy of the future, critically important to Europe and the world. My ambitious, high gain research plan is underpinned in the use of multiphase systems with ultra-low interfaci",{"id":599,"funder":7,"programme":8,"title":600,"piName":14,"institution":601,"country":602,"year":13,"amount":603,"abstract":604},"cordis-european-research-council-award-789339","Topological Insulator Laser","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","IL","€1,864,000","Triggered by condensed matter, a new frontier recently emerged: Photonic Topological Insulators (PTIs). These are photonic structures where the transport of light is topologically protected: light propagates in a unidirectional manner without reflection, even in the presence of corners, defects, or disorder. The first step toward PTIs was the electromagnetic analogue of the quantum Hall effect, employing magnetic fields in gyrooptic media. Bringing the concepts of topological insulators into pho",{"id":606,"funder":7,"programme":8,"title":607,"piName":14,"institution":608,"country":27,"year":13,"amount":609,"abstract":610},"cordis-european-research-council-award-787510","Four-Dimensional Monitoring of Tumour Growth by Surface Enhanced Raman Scattering","ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE","€2,410,771","Optical bioimaging is limited by visible light penetration depth and stability of fluorescent dyes over extended periods of time. Surface enhanced Raman scattering (SERS) offers the possibility to overcome these drawbacks, through SERS-encoded nanoparticle tags, which can be excited with near-IR light (within the biological transparency window), providing high intensity, stable, multiplexed signals. SERS can also be used to monitor relevant bioanalytes within cells and tissues, during the develo",{"id":612,"funder":7,"programme":8,"title":613,"piName":14,"institution":614,"country":27,"year":13,"amount":615,"abstract":616},"cordis-european-research-council-award-789104","FREE ELECTRONS AS ULTRAFAST NANOSCALE PROBES","FUNDACIO INSTITUT DE CIENCIES FOTONIQUES","€1,899,788","With eNANO I will introduce a disruptive approach toward controlling and understanding the dynamical response of material nanostructures, expanding nanoscience and nanotechnology in unprecedented directions. Specifically, I intend to inaugurate the field of free-electron nanoelectronics, whereby electrons evolving in the vacuum regions defined by nanostructures will be generated, guided, and sampled at the nanoscale, thus acting as probes to excite, detect, image, and spectrally resolve polarito",{"id":618,"funder":7,"programme":8,"title":619,"piName":14,"institution":620,"country":141,"year":13,"amount":621,"abstract":622},"cordis-european-research-council-award-743263","Understanding the Stability and Plasticity of Emotional Memory","UNIVERSITEIT VAN AMSTERDAM","€2,498,328","The breakthrough discovery in animal research that fear memories may change upon retrieval – referred to as memory reconsolidation – has drastically changed the view on the malleability of emotional memory. Inspired by these insights, we have developed a novel approach to pharmacologically erase the affective component from fear memories in humans. Although these findings suggest a paradigm shift in clinical practice, there are many fundamental questions to be resolved.The objective of this prop",{"id":624,"funder":7,"programme":8,"title":625,"piName":14,"institution":232,"country":125,"year":13,"amount":626,"abstract":627},"cordis-european-research-council-award-787926","Ribosome Processivity and Co-translational Protein Folding","€2,482,600","Protein domains start to fold co-translationally while they are being synthesized on the ribosome. Co-translational folding starts in the confined space of the ribosomal polypeptide exit tunnel and is modulated by the speed of translation. Although defects in protein folding cause many human diseases, the mechanisms of co-translational folding and the link between the speed of translation and the quality of protein folding is poorly understood. Here I propose to study when, where and how protein",{"id":629,"funder":7,"programme":8,"title":630,"piName":14,"institution":232,"country":125,"year":13,"amount":631,"abstract":632},"cordis-european-research-council-award-789016","How does the ubiquitin-like protein NEDD8 activate ubiquitin ligase machineries?","€2,193,871","Post-translational modification by ubiquitin and ubiquitin-like proteins (UBLs) is a major eukaryotic regulatory mechanism.  Nonetheless, we have little understanding of the detailed mechanisms by which most E3 ligases mark specific targets with monoubiquitin, multiple ubiquitins or specific polyubiquitin chains, or of how UBL modifications transform the functions of their targets.  This proposal addresses both problems.  First, we will discover the structural mechanisms by which the UBL NEDD8 (",{"id":634,"funder":7,"programme":8,"title":635,"piName":14,"institution":636,"country":62,"year":13,"amount":637,"abstract":638},"cordis-european-research-council-award-787520","Quantum Mechanics in the Negative Mass Reference Frame","KOBENHAVNS UNIVERSITET","€2,178,574","A fundamental aspect of quantum mechanics is the balance between information and disturbance by the measurement. A textbook example is the measurement of a position of an object which imposes a random perturbation on its momentum. This perturbation, the quantum back action, translates with time into uncertainty of the motion trajectory. The PI has proposed an approach which allows for simultaneous measurements of arbitrary small disturbances in both the position and the momentum. It is based on ",{"id":640,"funder":7,"programme":8,"title":641,"piName":14,"institution":642,"country":69,"year":13,"amount":643,"abstract":644},"cordis-european-research-council-award-789340","New Frontiers in Nanophotonics: Integrating Complex Beams and Active Metasurface Devices","KING'S COLLEGE LONDON","€2,737,327","Complex, structured optical beams have unique properties offering new degrees of freedom for achieving unusual wavefront, polarisation and optical angular momentum demanded in microscopy, optical trapping and manipulation of nano-objects, information encoding in optical communications, holography, quantum technologies and laser micromachining. Metasurfaces, a subwavelength-thin nanostructured films, which were initially developed for controlling the phase of light and its reflection and transmis",{"id":646,"funder":7,"programme":8,"title":647,"piName":14,"institution":648,"country":227,"year":13,"amount":649,"abstract":650},"cordis-european-research-council-award-741413","Humans On Planet Earth - Long-term impacts on biosphere dynamics","UNIVERSITETET I BERGEN","€2,278,884","A critical question in Earth system science is what was the impact of prehistoric people on the biosphere and climate? There is much information about human impact through clearance, agriculture, erosion, and modifying water and nutrient budgets. Humans have greatly changed the Earth in the last 8000 years, but did humans modify the major ecological processes (e.g. assembly rules) that shape community assembly and dynamics? Did inter-relationships between processes change in response to human im",{"id":652,"funder":7,"programme":8,"title":653,"piName":14,"institution":367,"country":322,"year":13,"amount":654,"abstract":655},"cordis-european-research-council-award-786462","Host Protective Engineering of Cancer Immunity by Targeting the Intracellular Immune Checkpoint NR2F6","€2,484,325","Because of its biological complexity, cancer is still poorly understood. Chronic inflammation has been shown, both experimentally and epidemiologically, to be a predisposition to, and also an inseparable aspect of clinically prevalent cancer entities. Therefore, a detailed understanding of both tumour and immune cell functions in cancer progression is a prerequisite for more successful therapeutic startegies. My team was the first to reveal the lymphocyte-intrinsic PKC\u002FNR2F6 axis as an essential",{"id":657,"funder":7,"programme":8,"title":658,"piName":14,"institution":213,"country":214,"year":13,"amount":102,"abstract":659},"cordis-european-research-council-award-788607","Studying Secondary Nucleation for the Intensification of Continuous Crystallization","Many products in the chemical, food and pharmaceutical industry are produced as powders through a crystallization process. Continuous crystallization has been for decades the process of choice for large-scale production, for instance of sugar, table salt, adipic acid, and has become more recently a key component of the new paradigm, i.e. the continuousmanufacturing of active pharmaceutical ingredients.All product crystals of continuous crystallization processes are formed through secondary nucle",{"id":661,"funder":7,"programme":8,"title":662,"piName":14,"institution":663,"country":125,"year":13,"amount":14,"abstract":664},"cordis-european-research-council-award-743077","Thermal Magnetic Resonance: A New Instrument to Define the Role of Temperature in Biological Systems and Disease for Diagnosis and Therapy","MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)","Temperature is a physical parameter with diverse biological implications and crucial clinical relevance. With an ever increasing interest in thermal applications, non-invasive in vivo methods to modulate temperature and characterize subsequent effects are imperative. Magnetic resonance (MR) is a mainstay of diagnosis but lacks inherent means for focal thermal modulation.Ultrahigh field (UHF) MR employs higher radio frequencies (RF) than conventional MR and has unique potential to provide focal t",{"id":666,"funder":7,"programme":8,"title":667,"piName":14,"institution":213,"country":214,"year":13,"amount":668,"abstract":669},"cordis-european-research-council-award-786580","Moduli, Algebraic Cycles, and Invariants","€2,496,055","Algebraic geometry is the study of varieties -- the zero sets of polynomial equations in several variables. The subject has a central role in mathematics with connections to number theory, representation theory, and topology. Moduli questions in algebraic geometry concern the behavior of varieties as the coefficients of the defining polynomials vary. At the end of the 20th century, several basic links between the algebraic geometry of moduli spaces and path integrals in quantum field theory were",{"id":671,"funder":7,"programme":8,"title":672,"piName":14,"institution":673,"country":214,"year":13,"amount":674,"abstract":675},"cordis-european-research-council-award-788949","Scents and sensibility in agriculture: exploiting specificity in herbivore- and pathogen-induced plant volatiles for real-time crop monitoring","UNIVERSITE DE NEUCHATEL","€2,498,086","Plants typically release large quantities of volatiles in response to attack by herbivores or pathogens. I may claim to have contributed to various breakthroughs in this research field, including the discovery that the volatile blends induced by different attackers are astonishingly specific, resulting in characteristic, readily distinguishable odour blends. Using maize as our model plant, I wish to take several leaps forward in our understanding of this signal specificity and use this knowledge",{"id":677,"funder":7,"programme":8,"title":678,"piName":14,"institution":679,"country":141,"year":13,"amount":680,"abstract":681},"cordis-european-research-council-award-788363","How intraflagellar transport shapes the cilium: a single-molecule systems study","STICHTING VU","€2,499,580","Sensory cilia are organelles extending like antennas from many eukaryotic cells, with crucial functions in sensing and signalling. Cilia consist of an axoneme built of microtubules, enveloped by a specialized membrane. Ciliary development and maintenance depend critically on a specific, microtubule-based intracellular transport mechanism, intraflagellar transport (IFT). In my laboratory, we study the chemosensory cilia of C. elegans, which sense water-soluble molecules in the animal’s environmen",{"id":683,"funder":7,"programme":8,"title":684,"piName":14,"institution":685,"country":21,"year":13,"amount":686,"abstract":687},"cordis-european-research-council-award-788205","History of the Tocharian Texts of the Pelliot Collection","ECOLE PRATIQUE DES HAUTES ETUDES","€1,833,103","HisTochText addresses written Buddhist culture of the northern Silk Road in an innovative and path-breaking way, by going beyond the frontier of disciplines which have been cultivated separately: philology, digital humanities and in-depth analysis of materials, edition of Tocharian texts and comparative Buddhist literature, Sanskrit poetics and narratology, texts and social contexts.The flourishing Buddhist culture of the northern Silk Road during the 1st millennium CE in the Tarim Basin in pres",{"id":689,"funder":7,"programme":8,"title":690,"piName":14,"institution":691,"country":112,"year":13,"amount":692,"abstract":693},"cordis-european-research-council-award-788793","Unveiling the relationship between brain connectivity and function by integrated photonics","UNIVERSITA DEGLI STUDI DI TRENTO","€2,499,825","I will address the fundamental question of which is the role of neuron activity and plasticity in information elaboration and storage in the brain. I, together with an interdisciplinary team, will develop a hybrid neuro-morphic computing platform. Integrated photonic circuits will be interfaced to both electronic circuits and neuronal circuits (in vitro experiments) to emulate brain functions and develop schemes able to supplement (backup) neuronal functions. The photonic network is based on mas",{"id":695,"funder":7,"programme":8,"title":696,"piName":14,"institution":697,"country":214,"year":13,"amount":698,"abstract":699},"cordis-european-research-council-award-787574","A Palaeoreanalysis To Understand Decadal Climate Variability","UNIVERSITAET BERN","€2,499,975","Climatic variations at decadal scales, such as phases of accelerated warming, weak monsoons, or widespread subtropical drought, have profound effects on society and the economy. Understanding such variations requires insights from the past. However, no data sets of past climate are available to study decadal variability of large-scale climate with state-of-the-art diagnostic methods. Currently available data sets are limited to statistical reconstructions of local or regional surface climate. Th",{"id":701,"funder":7,"programme":8,"title":702,"piName":14,"institution":703,"country":141,"year":13,"amount":704,"abstract":705},"cordis-european-research-council-award-787241","Complement: to clear or not to clear","UNIVERSITEIT UTRECHT","€2,332,500","Mammalian complement recognizes a variety of cell-surface danger and damage signals to clear invading microbes and injured host cells, while protecting healthy host cells. Improper complement responses contribute to diverse pathologies, ranging from bacterial infections up to paralyzing Guillain-Barré syndrome and schizophrenia. What determines the balance between complement attack reactions and host-cell defense measures and, thus, what drives cell fate is unclear.My lab has a long-standing tra",{"id":707,"funder":7,"programme":8,"title":708,"piName":14,"institution":709,"country":69,"year":13,"amount":710,"abstract":711},"cordis-european-research-council-award-787073","Assembly-disassembly-organisation-reassembly of microporous materials","THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS","€2,489,220","Microporous materials are an important class of solid; the two main members of this family are zeolites and metal-organic frameworks (MOFs). Zeolites are industrial solids whose applications range from catalysis, through ion exchange and adsorption technologies to medicine. MOFs are some of the most exciting new materials to have been developed over the last two decades, and they are just beginning to be applied commercially. Over recent years the applicant’s group has developed new synthetic st",{"id":713,"funder":7,"programme":8,"title":714,"piName":14,"institution":715,"country":602,"year":13,"amount":716,"abstract":717},"cordis-european-research-council-award-788715","From Local Elements to Globally Ordered TOPological states of matter","WEIZMANN INSTITUTE OF SCIENCE","€1,532,163","We present a novel constructive approach for realizations of topological states of matter. Our approach starts with well-understood building blocks, and proceeds towards coupling them to create the desired states. This approach promises both a guide for a tunable experimental realization of states which have not been observed so far, and a theoretical tool for deeper understanding of different topological states, their dualities and inter-relations.We will apply the constructive approach in two ",{"id":719,"funder":7,"programme":8,"title":720,"piName":14,"institution":721,"country":595,"year":13,"amount":722,"abstract":723},"cordis-european-research-council-award-788448","Gulag Echoes in the “multicultural prison”: historical and geographical influences on the identity and politics of ethnic minority prisoners in the communist successor states of Russia Europe.","HELSINGIN YLIOPISTO","€2,494,685","The project will examine the impact of the system of penality developed in the Soviet gulag on the ethnic identification and political radicalisation of prisoners in the Soviet Union and the communist successor states of Europe today. It is informed by the proposition that prisons are sites of ethnic identity construction but that the processes involved vary within and between states. In the project, the focus is on the extent to which particular prison-styles affect the social relationships, se",{"id":725,"funder":7,"programme":8,"title":726,"piName":14,"institution":642,"country":69,"year":13,"amount":102,"abstract":727},"cordis-european-research-council-award-787355","Developmental principles for the functional specialisation of inhibitory circuits in neocortical areas","The mammalian neocortex consists of discrete, but highly interconnected, functional areas that collectively encode features of the environment, form associations between stimuli and drive behaviour by transforming sensory input into motor output. All neocortical areas are organised into six layers containing two major classes of neurons, excitatory glutamatergic pyramidal cells and inhibitory GABAergic interneurons. However, each area has distinctive cytoarchitectonical features and inputs that ",{"id":729,"funder":7,"programme":8,"title":730,"piName":14,"institution":614,"country":27,"year":13,"amount":731,"abstract":732},"cordis-european-research-council-award-788218","Structural transformations and phase transitions in real-time","€2,471,749","Chemical and material sciences are key drivers of our modern economy with transformative impact at all levels of society. In particular, the ability to synthesize and to tailor substances and materials with specific function is all-pervading into modern society. Vital is a firm understanding of structural transformations of molecules and phase transitions of solids as they are omnipresent, e.g. as formation and breakage of molecular bonds, proton motion and isomerization, and as collective pheno",{"id":734,"funder":7,"programme":8,"title":735,"piName":14,"institution":328,"country":322,"year":13,"amount":736,"abstract":737},"cordis-european-research-council-award-787613","De novo Development of Polarity in Plant Cells","€2,499,224","The polarity of the single cell from which many organisms develop determines the polarity of the body axis. However, the polarity of these single cells is often inherited.  For example, zygote polarity is inherited from the polarized egg cell of Arabidopsis thaliana.  By contrast, polarity is not pre-set in the spore cell that forms the Marchantia polymorpha (Marchantia) plant.  An environmental cue – directional light – polarises the spore cell which, in turn, directs the formation of the first",{"id":739,"funder":7,"programme":8,"title":740,"piName":14,"institution":741,"country":141,"year":13,"amount":742,"abstract":743},"cordis-european-research-council-award-787675","Decoding the Nature of Flapping Flight by port-Hamiltonian System Theory","UNIVERSITEIT TWENTE","€2,800,000","Flapping flight is one of the wonders of nature and has been vastly studied by biologists and fluid dynamicists. Many artifacts that mimic biological systems have been built at different scales.For example, we have managed to create a system that resembles the steady flapping behaviour of its biological counterpart and can fly untethered, stably up to 80 km\u002Fh in up to 5 Beaufort wind speed. This is the Robird developed at the University of Twente, which got the 2016 ERF Tech Transfer Award, and ",{"id":745,"funder":7,"programme":8,"title":746,"piName":14,"institution":747,"country":21,"year":13,"amount":102,"abstract":748},"cordis-european-research-council-award-788476","Elites, networks, and power in modern urban China (1830-1949).","UNIVERSITE D'AIX MARSEILLE","This project proposes a step-change in the study of modern China reliant upon scalable data-rich history. It will deliver precise historical information at an unprecedented scale from heretofore untapped sources - as well as reshaping the analysis of existing sources - to create a new dimension in the study of the transformation of elites in modern China. It will deploy an array of cutting-edge digital methods — including data mining, sampling, and analysis within an integrated virtual research ",{"id":750,"funder":7,"programme":8,"title":751,"piName":14,"institution":752,"country":69,"year":13,"amount":753,"abstract":754},"cordis-european-research-council-award-786142","Elaboration of the type I interferonopathies","THE UNIVERSITY OF EDINBURGH","€2,418,800","Type I interferons represent both key molecules in anti-viral defence and mediators of inflammatory disease, so that the induction, transmission and resolution of the interferon response are tightly regulated - balancing protection against infection versus the risk of immunopathology. Monogenic type I interferonopathies (T1IFNs), and related ‘complex’ phenotypes such as systemic lupus erythematosus and dermatomyositis, represent examples of a disturbance of the homeostatic control of this system",{"id":756,"funder":7,"programme":8,"title":757,"piName":14,"institution":758,"country":141,"year":13,"amount":759,"abstract":760},"cordis-european-research-council-award-788618","Synthesis of Functional Multi-Component Supramolecular Systems and Materials","TECHNISCHE UNIVERSITEIT EINDHOVEN","€2,499,929","This ERC proposal targets novel synthetic strategies to arrive at functional multi-component systems and materials. They possess architectures of such high complexity that it is hard to imagine access to these systems by self-assembly or self-organization only. We will explore tools required to introduce multi-step non-covalent synthesis. We have taken inspiration from Nature, but more importantly we propose to mimic the impressive progress in the field of covalent organic and polymer synthesis.",{"id":762,"funder":7,"programme":8,"title":763,"piName":14,"institution":764,"country":125,"year":13,"amount":102,"abstract":765},"cordis-european-research-council-award-787446","Correlating the State and Properties of Grain Boundaries","MAX-PLANCK-INSTITUT FUR NACHHALTIGE MATERIALIEN GMBH","Phase diagrams revolutionized materials development by predicting the conditions for phase stability and transformations, providing a thermodynamic concept for materials design including synthesis, processing and application. Similarly, surface science has established thermodynamic concepts for surface states and transitions, but the analogon for grain boundaries (GB) is just emerging due to their complexity. GB are among the most prominent microstructure defects separating grains in polycrystal",{"id":767,"funder":7,"programme":8,"title":768,"piName":14,"institution":715,"country":602,"year":13,"amount":14,"abstract":769},"cordis-european-research-council-award-786949","An open or closed process: Determining the global scheme of perception","Despite decades of intensive research, there is no agreement about the general scheme of perception: Is the external object a trigger for a brain-internal process (open-loop perception, OLP) or is the object included in brain dynamics during the entire perceptual process (closed-loop perception, CLP)? HOWPER is designed to provide a definite answer to this question in the cases of human touch and vision. What enables this critical test is our development of an explicit CLP hypothesis, which will",{"id":771,"funder":7,"programme":8,"title":772,"piName":14,"institution":773,"country":141,"year":13,"amount":102,"abstract":774},"cordis-european-research-council-award-788980","Energy-optimized Symmetric Cryptography by Algebraic Duality Analysis","STICHTING RADBOUD UNIVERSITEIT","The main scientific contribution of this project will be a breakthrough in the understanding of cryptanalytic and side channel attacks of symmetric cryptosystems. We will do this by a unification of attacks that will a stepping stone to the holy grail of symmetric cryptography: provable security of concrete cryptosystems. The main real-world impact is that we will build cryptosystems that are much more efficient than those used today while having the same strength. Depending on the platform, hig",{"id":776,"funder":7,"programme":8,"title":777,"piName":14,"institution":778,"country":27,"year":13,"amount":779,"abstract":780},"cordis-european-research-council-award-788222","Molecule-induced control over 2D Materials","UNIVERSITAT DE VALENCIA","€2,499,950","We propose to create heterostructures based on functional molecules and 2D materials. As molecular systems we focus on bistable magnetic molecules able to switch between two spin states upon the application of an external stimulus (temperature, light, pressure, electric field etc.). As 2D materials we concentrate on those exhibiting in particular superconductivity or magnetism. The driving idea is to tune\u002Fimprove the properties of the “all surface” 2D material via an active control of the hybrid",{"id":782,"funder":7,"programme":8,"title":783,"piName":14,"institution":784,"country":27,"year":13,"amount":785,"abstract":786},"cordis-european-research-council-award-742265","Polarized Radiation Diagnostics for Exploring the Magnetism of the Outer Solar Atmosphere","INSTITUTO DE ASTROFISICA DE CANARIAS","€2,478,750","POLMAG aims at a true breakthrough in the development and application of polarized radiation diagnostic methods for exploring the magnetic fields of the chromosphere, transition region and corona of the Sun via the interpretation of the Stokes profiles produced by optically polarized atoms and the Hanle and Zeeman effects in ultraviolet (UV), visible and near-infrared spectral lines. To this end, POLMAG will combine and expand expertise on atomic physics, on the quantum theory of radiation, on h",{"id":788,"funder":7,"programme":8,"title":789,"piName":14,"institution":288,"country":69,"year":13,"amount":790,"abstract":791},"cordis-european-research-council-award-787413","Manipulating Acoustic wavefronts using metamaterials for novel user interfaces","€2,457,718","In this project we will leverage developments in acoustic meta-materials to build interactive systems that manipulate sound to create experiences with the same ease and fidelity as we are so accustomed to doing with light. This involves designing and evaluating new acoustic meta-materials AND building interactive systems that create novel interaction experiences that were hitherto impossible to achieve.We will use acoustic metamaterials technology to build a Spatial Sound Modulator (SSM) that ai",{"id":793,"funder":7,"programme":8,"title":794,"piName":14,"institution":795,"country":112,"year":13,"amount":796,"abstract":797},"cordis-european-research-council-award-742436","HD-DittoGraph: a digital human Embryonic Stem Cell platform for Huntington's repeats","UNIVERSITA DEGLI STUDI DI MILANO","€2,040,943","This proposal is aimed at identifying the molecular mechanisms that have brought the human Huntington Disease-causing Huntingtin (Htt) exon 1, with its pure and unstable CAG repeat, to be shaped the way it is today. Specifically, we intend to screen for genetic elements affecting Htt repeat length instability in dividing and postmitotic neuronal cells. The novelty of our approach relies on the construction of a human embryonic stem (hES) cell platform that couples highly efficient CRISPR\u002FCas9 te",{"id":799,"funder":7,"programme":8,"title":800,"piName":14,"institution":153,"country":34,"year":13,"amount":801,"abstract":802},"cordis-european-research-council-award-787960","Exploring Duality for Future Data-driven Modelling","€2,492,500","Future data-driven modelling is increasingly challenging for many systems due to higher complexity levels, such as in energy systems, environmental and climate modelling, traffic and transport, industrial processes, health, safety, and others. This requires powerful concepts and frameworks that enable the design of high quality predictive models. In this proposal E-DUALITY we will explore and engineer the potential of duality principles for future data-driven modelling. An existing example illus",{"id":804,"funder":7,"programme":8,"title":805,"piName":14,"institution":806,"country":125,"year":13,"amount":485,"abstract":807},"cordis-european-research-council-award-786834","Mechanisms of epigenetic gene regulation by R-loops","INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH","The last decade has revolutionized our thinking about regulatory RNAs and yet we are still at the beginning of understanding their biology. One such challenge is presented by R-loops, prevalent DNA:RNA hybrids, which lie at the interface of different nuclear processes, including transcription, RNA processing, lncRNAs, DNA damage, chromatin, and neurodegenerative disease. Long-time considered a threat to genomic integrity, recent evidence indicates that certain R-loops can act as epigenetic gene ",{"id":809,"funder":7,"programme":8,"title":810,"piName":14,"institution":271,"country":112,"year":13,"amount":811,"abstract":812},"cordis-european-research-council-award-788893","Algorithmic and Mechanism Design Research in Online MArkets","€1,780,150","Online markets currently form an important  share of the global economy.  The Internet hosts classical markets (real-estate, stocks, e-commerce) as well allowing new markets with previously unknown features (web-based advertisement, viral marketing,  digital goods, crowdsourcing, sharing economy).  Algorithms play a central role in many decision processes involved in online markets.  For example,  algorithms  run electronic auctions, trade stocks,  adjusts prices dynamically, and harvest big dat",{"id":814,"funder":7,"programme":8,"title":815,"piName":14,"institution":816,"country":69,"year":13,"amount":817,"abstract":818},"cordis-european-research-council-award-786734","Heterometallic Rings for Future Electronics","THE UNIVERSITY OF MANCHESTER","€2,477,003","The proposal is to use our great synthetic control to examine the use of heterometallic cyclic coordination compounds (heterometallic rings, HRs) in two distinct application areas. One is of immediate impact: the use of the HRs as resist materials for lithography. This work has already been patented and is being developed as a means to fabricate devices that will be needed at the 7 nm node and smaller. The synthetic control also means we can make resists for extreme UV lithography (13 nm wavelen",{"id":820,"funder":7,"programme":8,"title":821,"piName":14,"institution":822,"country":823,"year":13,"amount":824,"abstract":825},"cordis-european-research-council-award-786314","Continuity and Rupture in Central European Art and Architecture, 1918-1939","Masarykova univerzita","CZ","€2,468,359","When new political elites and social structures emerge out of a historical rupture, how are art and architecture affected? In 1918 the political map of central Europe was redrawn as a result of the collapse of Austria-Hungary, marking a new era for the region. Through comparative analysis of the visual arts in 3 states built on the ruins of the Habsburg Empire (Austria, Hungary and [former] Czechoslovakia), this project examines how such political discontinuity affected art and architecture betw",{"id":827,"funder":7,"programme":8,"title":828,"piName":14,"institution":334,"country":69,"year":13,"amount":829,"abstract":830},"cordis-european-research-council-award-742808","Effects of group dynamics on selection, development and demography in cooperative vertebrates","€2,499,244","In social animals, the characteristics and dynamics of groups affect the development of individuals, the selection pressures operating on them and the demography of populations.  Using existing study populations of two social mammals (Kalahari meerkats and Damaraland mole-rats) that offer unique and complementary opportunities for research, we shall (1) explore the effects of variation in group size on growth, behaviour, hormonal status and gene regulation in both species and test suggestions th",{"id":832,"funder":7,"programme":8,"title":833,"piName":14,"institution":834,"country":322,"year":13,"amount":835,"abstract":836},"cordis-european-research-council-award-741950","Understanding the Role of Material Stock Patterns for the Transformation to a Sustainable Society","UNIVERSITAET FUER BODENKULTUR WIEN","€2,483,686","Sustainability transformations imply fundamental changes in the societal use of biophysical resources. Current socioeconomic metabolism research traces flows of energy, materials or substances to capture resource use: input of raw materials or energy, their fate in production and consumption, and the discharge of wastes and emissions. This approach has yielded important insights into eco-efficiency and long-term drivers of resource use. But due to its focus on flows, socio-metabolic research has",{"id":838,"funder":7,"programme":8,"title":839,"piName":14,"institution":840,"country":34,"year":13,"amount":841,"abstract":842},"cordis-european-research-council-award-789384","Role of protein crystallization in type 2 immunity and asthma","VIB VZW","€2,499,846","Spontaneous protein crystallization is a rare event in biology. Eosinophilic inflammation such as seen in the airways in asthma, chronic rhinosinusitis and helminth infection is however accompanied by accumulation of large amounts of extracellular Charcot-Leyden crystals. These are made of Galectin-10, a protein of unknown function produced by eosinophils, hallmark cells of type 2 immunity. In mice, eosinophilic inflammation is also accompanied by protein crystal build up, composed of the chitin",{"id":844,"funder":7,"programme":8,"title":845,"piName":14,"institution":846,"country":602,"year":13,"amount":847,"abstract":848},"cordis-european-research-council-award-786575","Tumor suppressive microRNAs for cancer therapy","THE HEBREW UNIVERSITY OF JERUSALEM","€2,840,729","The challenge for cancer therapy involves hampering the mechanisms by which the normal gene expression machinery is taken over to allow the aberrant appearance of cancer driving genes. I propose exploiting the therapeutic potential of a special class of tumor microRNAs (miRs) that function as natural post-transcriptional tumor suppressive regulators of many genes in key pathways. These anti-cancer effectors represent an inherent organismal property that I propose to augment and thereby translate",{"id":850,"funder":7,"programme":8,"title":851,"piName":14,"institution":852,"country":125,"year":13,"amount":853,"abstract":854},"cordis-european-research-council-award-787181","Mechanisms of vascular maturation and quiescence during development, homeostasis and aging","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","€2,338,918","Angiogenesis research has focused on the sprouting of new capillaries. The mechanisms of vessel maturation are much less well understood. Yet, the maintenance of a mature, quiescent, and organotypically-differentiated layer of endothelial cells (ECs) lining the inside of all blood vessels is vital for human health. The goal of ANGIOMATURE is to identify, validate, and implement novel mechanisms of vascular maturation and organotypic EC differentiation that are active during development, maintena",{"id":856,"funder":7,"programme":8,"title":857,"piName":14,"institution":614,"country":27,"year":13,"amount":858,"abstract":859},"cordis-european-research-council-award-788546","Membrane-based nano-mechanobiology: Role of mechanical forces in remodelling the spatiotemporal nanoarchitecture of the plasma membrane","€2,212,063","Through evolution, cells have developed the exquisite ability to sense, transduce and integrate mechanical and biochemical signals (i.e. mechanobiology) to generate appropriate responses. These key events are rooted at the molecular and nanoscale levels, a size regime difficult to access, hindering our progress towards mechanistic understanding of mechanobiology. Recent evidence from my Lab (and others) shows that the lateral nanoscale organisation of mechanosensitive membrane receptors and sign",{"id":861,"funder":7,"programme":8,"title":862,"piName":14,"institution":863,"country":864,"year":13,"amount":865,"abstract":866},"cordis-european-research-council-award-789341","Killer plasmids as drivers of genetic code changes during yeast evolution","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","IE","€2,368,356","The genetic code was established at a very early stage during the evolution of life on Earth and is nearly universal. In eukaryotic nuclear genes, the only known examples of a sense codon that underwent an evolutionary change of meaning, from one amino acid to another, occur in yeast species. The codon CUG is translated as Leu in the universal genetic code, but it has long been known to be translated as Ser in some Candida species. In recent work, we discovered that this switch is one of three p",{"id":868,"funder":7,"programme":8,"title":869,"piName":14,"institution":870,"country":864,"year":13,"amount":871,"abstract":872},"cordis-european-research-council-award-788753","Regeneration of Articular Cartilage using Advanced Biomaterials and Printing Technology","ROYAL COLLEGE OF SURGEONS IN IRELAND","€2,999,410","Adult articular cartilage has a limited capacity for repair and when damaged or injured, experiences a loss of function which leads to joint degeneration and ultimately osteoarthritis.  Biomaterials-based treatments have had very limited success due to the complex zonal structure of the articular joint,  problems with biomaterial retention at the joint surface and achieving integration with the host tissue while also maintaining load bearing capacity.  Stem cell therapies have also failed to liv",{"id":874,"funder":7,"programme":8,"title":875,"piName":14,"institution":876,"country":125,"year":13,"amount":102,"abstract":877},"cordis-european-research-council-award-742712","Chiral Morphogenesis - Physical Mechanisms of Actomyosin-Based Left\u002FRight Symmetry Breaking in Biological Systems","TECHNISCHE UNIVERSITAET DRESDEN","The aim of this grant is to understand how cellular, tissue-scale and organismal left-right asymmetry arisesfrom the chirality of molecular constituents. In many instances the actomyosin cortex, a thin andmechanically active layer of dynamically cross-linked filaments and molecular motors at the surface of cells,drives the emergence of chiral morphogenetic events. In the nematode Caenorhabditis elegans, mesoscalechiral active torques generated by this active layer establish the embryo’s left-rig",{"id":879,"funder":7,"programme":8,"title":880,"piName":14,"institution":773,"country":141,"year":13,"amount":881,"abstract":882},"cordis-european-research-council-award-787622","A large-scale radio detector for the Pierre Auger cosmic-ray Observatory – precision measurements of ultra-high-energy cosmic rays","€3,499,249","Cosmic Rays (ionized atomic nuclei) are the only matter from beyond our solar system or even from extragalactic space, that we can directly investigate. Up to energies of 10^17 eV they most likely originate in our Galaxy. The highest-energy cosmic rays (>10^18 eV) cannot be magnetically bound any more to the Galaxy and are most likely of extragalactic origin.The pure existence of these particles raises the question about their origin – how and where are they accelerated? How do they propagate th",{"id":884,"funder":7,"programme":8,"title":885,"piName":14,"institution":886,"country":62,"year":13,"amount":887,"abstract":888},"cordis-european-research-council-award-786643","New energy Consumer roles and smart technologies – Actors, Practices and Equality","AALBORG UNIVERSITET","€2,116,000","The transition to a low-carbon society is vital and requires major changes in everyday life for European households, including new prosumer roles linking renewable energy production and household consumption by use of smart technologies. This implies major alterations in the materiality as well as the social organisation of everyday life. To guide this low-carbon transition, new theory development on the role of technological systems in everyday life is needed. Practice theories represent a stro",{"id":890,"funder":7,"programme":8,"title":891,"piName":14,"institution":271,"country":112,"year":13,"amount":892,"abstract":893},"cordis-european-research-council-award-789058","Embodied Honesty in Real World and Digital Interactions","€2,497,188","Every day, everywhere, people make unethical choices ranging from minor selfish lies to massive frauds, with dramatic individual and societal costs. Embodied cognition theories posit that even seemingly abstract processes (like grammar) may be biased by the body-related signals used for building and maintaining self-consciousness, the fundamental experience of owning a body (ownership) and being the author of an action (agency), that is at the basis of self-other distinction. Applying this frame",{"id":895,"funder":7,"programme":8,"title":896,"piName":14,"institution":620,"country":141,"year":13,"amount":897,"abstract":898},"cordis-european-research-council-award-743086","A Unified Framework for the Assessment and Application of Cognitive Models","€2,493,318","Cognitive models formalize substantive theory about how people reason, learn, decide, and act. Cognitive models also serve as measurement tools that explain observed behavior in terms of constituent psychological processes. Because of their unique ability to estimate latent processes, cognitive models are increasingly applied throughout cognitive neuroscience and clinical psychology. Despite their theoretical appeal and growing popularity, however, the field of cognitive modeling presents an oft",{"id":900,"funder":7,"programme":8,"title":901,"piName":14,"institution":902,"country":27,"year":13,"amount":102,"abstract":903},"cordis-european-research-council-award-789051","Optimal Control of Thermal Solar Energy Systems","UNIVERSIDAD DE SEVILLA","OCONTSOLAR aims to develop new control methods to use mobile sensors mounted on drones and unmanned ground vehicles (UGV) as an integral part of the control systems. Sensors mounted on vehicles have been used for surveillance and for gathering information, however these mobile sensors have not been used so far as an integral part of control systems. Solar power plants will be used as a case study, with the aim of optimizing their operation using spatial irradiance estimations and predictions. Ma",{"id":905,"funder":7,"programme":8,"title":906,"piName":14,"institution":715,"country":602,"year":13,"amount":907,"abstract":908},"cordis-european-research-council-award-788194","Novel strategies for mammalian cardiac repair","€2,268,750","Recent ground-breaking studies by my team and others demonstrated that latent heart regeneration machinery can be awakened even in adult mammals. My lab’s main contribution is the identification of two, apparently different, molecular mechanisms for augmenting cardiac regeneration in adult mice. The first requires transient activation of ErbB2 signalling in cardiomyocytes and the second involves extra cellular matrix-driven signalling by the proteoglycan agrin. Impressively, both mechanisms prom",{"id":910,"funder":7,"programme":8,"title":911,"piName":14,"institution":715,"country":602,"year":13,"amount":912,"abstract":913},"cordis-european-research-council-award-785971","Thermal imaging of nano and atomic-scale dissipation in quantum states of matter","€3,075,000","Energy dissipation is a fundamental process governing the dynamics of physical, chemical and biological systems and is of major importance in condensed matter physics where scattering, loss of quantum information, and even breakdown of topological protection are deeply linked to intricate details of how and where the dissipation occurs. But despite its vital importance, dissipation is currently not a readily measurable microscopic quantity. The aim of this proposal is to launch a new discipline ",{"id":915,"funder":7,"programme":8,"title":916,"piName":14,"institution":917,"country":141,"year":13,"amount":102,"abstract":918},"cordis-european-research-council-award-742225","A single-cell genomics approach integrating gene expression, lineage, and physical interactions","KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW","From populations of unicellular organisms to complex tissues, cell-to-cell variability in phenotypic traits seems to be universal. To study this heterogeneity and its biological consequences, researchers have used advanced microscopy-based approaches that provide exquisite spatial and temporal resolution, but these methods are typically limited to measuring a few properties in parallel. On the other hand, next generation sequencing technologies allow for massively parallel genome-wide approaches",{"id":920,"funder":7,"programme":8,"title":921,"piName":14,"institution":213,"country":214,"year":13,"amount":922,"abstract":923},"cordis-european-research-council-award-786461","Statistics, Prediction and Causality for Large-Scale Data","€2,184,375","Understanding cause-effect relationships between variables is of great interest in many fields of science. However, causal inference from data is much more ambitious and difficult than inferring (undirected) measures of association such as correlations, partial correlations or multivariate regression coefficients, mainly because of fundamental identifiabilityproblems. A main objective of the proposal is to exploit advantages from large-scale heterogeneous data for causal inference where heteroge",{"id":925,"funder":7,"programme":8,"title":926,"piName":14,"institution":927,"country":69,"year":13,"amount":928,"abstract":929},"cordis-european-research-council-award-786851","Flying Electromagnetic Toroids","UNIVERSITY OF SOUTHAMPTON","€2,570,198","In this project I will study the generation, detection, and interaction with matter of Flying Toroids, a new type of light pulses never experimentally studied before. This represents an exciting opportunity to advance optics and electromagnetism in a radically new direction since Hertz, Marconi, Popov and Tesla developed technology for generating, detecting, and communicating with transverse electromagnetic waves. Conventional transverse electromagnetic waves propagate in free-space with the ele",{"id":931,"funder":7,"programme":8,"title":932,"piName":14,"institution":663,"country":125,"year":13,"amount":102,"abstract":933},"cordis-european-research-council-award-789128","Tethers for sensory mechanotransduction: from molecules to perception","Touch sensation is built upon the ability of sensory neurons to detect and transduce nanometer scale mechanical displacements. The underlying process has been termed mechanotransduction: the high sensitivity and speed of which is enabled by direct gating (opening) of ion channels by mechanical force. Force detection is functionally compartmentalized and only takes place at the peripheral endings of sensory neurons in vivo. Two molecules are known to be genetically necessary for touch in many sen",{"id":935,"funder":7,"programme":8,"title":936,"piName":14,"institution":395,"country":27,"year":13,"amount":937,"abstract":938},"cordis-european-research-council-award-787842","The sound of special places: exploring rock art soundscapes and the sacred","€2,239,375","The ARTSOUNDSCAPES project deals with sound, rock art and sacred landscapes among past hunter-gatherers and early agricultural societies around the world. The potential of sound to stimulate powerful emotions makes it a common medium for conferring places with extraordinary agency. Ethnographic and ethnohistorical sources indicate that these sites are often endowed with a sacred significance and, in many cases, they also receive special treatment, including the production of rock paintings. Desp",{"id":940,"funder":7,"programme":8,"title":941,"piName":14,"institution":721,"country":595,"year":13,"amount":942,"abstract":943},"cordis-european-research-council-award-787758","The Gödel Enigma: Unveiling a Hidden Logical Heritage","€2,132,993","Research in logic and foundations of mathematics received an enormous impact through the incompleteness theorems that Kurt Gödel published in 1931. They are among the most iconic scientific achievements of the 20th century. These results led to the development of true formal systems and to the notions of formal languages and algorithmic computability that are connected to such names as Alonzo Church and Alan Turing. The said notions are the direct basis on which the first programming languages a",{"id":945,"funder":7,"programme":8,"title":946,"piName":14,"institution":947,"country":125,"year":13,"amount":102,"abstract":948},"cordis-european-research-council-award-786306","At the crossroad of molecular physics, quantum optics and spectroscopy: ultra-high-precision molecular spectroscopy for fundamental physics","HEINRICH-HEINE-UNIVERSITAET DUESSELDORF","Molecules have an enormous potential in the field of frequency metrology-based fundamental physics, yet have so far not played an important role, due to difficult experimental challenges. The goal of this project is to overcome these difficulties by developing new techniques, thus opening a new chapter in precision molecular spectroscopy. Furthermore, it will have far-reaching impact in fundamental physics: (1) A 500-fold improved limit to the existence of a “fifth force” with range on the 0.1 n",{"id":950,"funder":7,"programme":8,"title":951,"piName":14,"institution":952,"country":125,"year":13,"amount":953,"abstract":954},"cordis-european-research-council-award-787544","Laboratory Experiments on Magnetic Phenomena in Geo- and Astrophysics","HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF EV","€2,493,250","Cosmic magnetic fields, including those of planets, stars, and galaxies, are being generated by the homogenous dynamo effect in flowing electrically conducting fluids. Once produced, these fields may play an active role in cosmic structure formation by fostering angular momentum transport and mass accretion onto central objects, like protostars or black holes, by means of the magnetorotational instability (MRI). Complementary to the decades-long theoretical research into both effects, the last y",{"id":956,"funder":7,"programme":8,"title":957,"piName":14,"institution":601,"country":602,"year":13,"amount":958,"abstract":959},"cordis-european-research-council-award-786976","Selective Functionalization of Saturated Hydrocarbons","€2,499,375","Despite that C–H functionalization represents a paradigm shift from the standard logic of organic synthesis, the selective activation of non-functionalized alkanes has puzzled chemists for centuries and is always referred to one of the remaining major challenges in chemical sciences. Alkanes are inert compounds representing the major constituents of natural gas and petroleum. Converting these cheap and widely available hydrocarbon feedstocks into added-value intermediates would tremendously affe",{"id":961,"funder":7,"programme":8,"title":962,"piName":14,"institution":963,"country":249,"year":13,"amount":102,"abstract":964},"cordis-european-research-council-award-787592","The impact of neighbourhoods, peers and families on psychiatric disorders, substance use disorders and crime in first- and second-generation immigrants","LUNDS UNIVERSITET","The successful integration of the high numbers of refugees is one of the most critical issues facing the EU today. We propose to identify factors at the neighbourhood-, family-, peer-, and individual-levels that may protect immigrant children, adolescents and adults from psychiatric disorders, substance use disorders, and crime. We have access to highly accurate and almost complete nationwide sociodemographic data from 1960-2015 including, but not limited to, country of birth, education, income,",{"id":966,"funder":7,"programme":8,"title":967,"piName":14,"institution":968,"country":249,"year":13,"amount":969,"abstract":970},"cordis-european-research-council-award-789410","HIDDeN - Exploring the Hidden Dusty Nuclei of Galaxies","CHALMERS TEKNISKA HOGSKOLA AB","€2,496,319","Luminous infrared galaxies (LIRGs) emit most of their bolometric luminosity in the far-infrared. They are mainly powered by extreme bursts of star formation and\u002For Active Galactic Nuclei (AGNs; accreting supermassive black holes (SMBHs)) in their centres. LIRGs are the closest examples of rapid evolution in galaxies and a detailed study of LIRGs is critical for our understanding of the cosmic evolution of galaxies and SMBHs. Centres of some LIRGs are deeply obscured and unreachable at optical, I",{"id":972,"funder":7,"programme":8,"title":973,"piName":14,"institution":974,"country":975,"year":13,"amount":976,"abstract":977},"cordis-european-research-council-award-787115","Molecular machines based on coiled-coil protein origami","KEMIJSKI INSTITUT","SI","€2,497,125","Proteins are the most versatile and complex smart nanomaterials, forming molecular machines and performing numerous functions from structure building, recognition, catalysis to locomotion. Nature however explored only a tiny fraction of possible protein sequences and structures. Design of proteins with new, in nature unseen shapes and features, offers high rewards for medicine, technology and science. In 2013 my group pioneered the design of a new type of modular coiled-coil protein origami (CCP",{"id":979,"funder":7,"programme":8,"title":980,"piName":14,"institution":406,"country":141,"year":13,"amount":14,"abstract":981},"cordis-european-research-council-award-785635","Pressured to Attack: How Carrying-Capacity Stress Creates and Shapes Intergroup Conflict","Throughout history, what has been causing tremendous suffering is groups of people fighting each other. While behavioral science research has advanced our understanding of such intergroup conflict, it has exclusively focused on micro-level processes within and between groups at conflict. Disciplines that employ a more historical perspective like climate studies or political geography report that macro-level pressures due to changes in climate or economic scarcity can go along with social unrest ",{"id":983,"funder":7,"programme":8,"title":984,"piName":14,"institution":383,"country":322,"year":13,"amount":985,"abstract":986},"cordis-european-research-council-award-742985","Tracing Evolution of Auxin Transport and Polarity in Plants","€2,410,292","Multicellularity in plants evolved independently from other eukaryotes and presents a unique, alternative way how to deal with challenges of life. A major plant developmental module is the directional transport for the plant hormone auxin. The crucial components are PIN auxin transporters, whose polar, subcellular localization determines directionality of auxin flow through tissues. PIN-dependent auxin transport represents a unique model for studying the functional link between basic cellular pr",{"id":988,"funder":7,"programme":8,"title":989,"piName":14,"institution":752,"country":69,"year":13,"amount":990,"abstract":991},"cordis-european-research-council-award-787270","Advancing knowledge to improve outcome in Paget’s disease of bone","€2,422,623","Paget’s disease of bone (PDB) is a common skeletal disorder in people of European descent characterised by abnormal bone remodeling which disrupts normal bone structure causing pain, deformity, nerve compression syndromes and fractures. The causes of PDB are incompletely understood. Genetic factors play a key role and some predisposing genes been identified but many remain to be discovered as do the mechanisms by which these genes influence bone cell function. Environmental factors also contribu",{"id":993,"funder":7,"programme":8,"title":994,"piName":14,"institution":995,"country":69,"year":13,"amount":102,"abstract":996},"cordis-european-research-council-award-787361","Convective Boundary Mixing in Stars","THE UNIVERSITY OF EXETER","Stellar evolution models are fundamental to nearly all fields of astrophysics, from exoplanet to galactic and extra-galactic research.The heart of the COBOM project is to develop a global physical picture of fundamental mixing processes in stars in order to derive robust and predictive stellar evolution models.The complex dynamics of flows at convective boundaries is a key process in stellar interiors that drives the transport of chemical species and heat, strongly affecting the structure and th",{"id":998,"funder":7,"programme":8,"title":999,"piName":14,"institution":1000,"country":125,"year":13,"amount":300,"abstract":1001},"cordis-european-research-council-award-788704","Ultrafast Structural Dynamics of Elementary Water-Mediated Proton Transport Processes","FORSCHUNGSVERBUND BERLIN EV","How acids and bases react in water is a question raised since the pioneering days of modern chemistry. Recent decades have witnessed an increased effort in elucidating the microscopic mechanisms of proton exchange between acids and bases and the important mediating role of water in this. With ultrafast spectroscopy it has been shown that the elementary steps in aqueous proton transfer occur on femtosecond to picosecond time scales. Aqueous acid-base neutralization predominantly proceeds in a seq",{"id":1003,"funder":7,"programme":8,"title":1004,"piName":14,"institution":213,"country":214,"year":13,"amount":102,"abstract":1005},"cordis-european-research-council-award-785800","Electrogenetics – Shaping Electrogenetic Interfaces for Closed-Loop Voltage-Controlled Gene Expression","Man and man-made electronic systems share the same ecosystem, and yet work radically differently. Human metabolism uses ion gradients across insulated membranes to simultaneously process slow analog chemical reactions and communicate information in multicellular systems via soluble\u002Fvolatile molecular signals. By contrast, electronic systems use multicore central processing units to control the flow of electrons through insulated metal wires with gigahertz frequency and communicate information ac",{"id":1007,"funder":7,"programme":8,"title":1008,"piName":14,"institution":570,"country":322,"year":13,"amount":102,"abstract":1009},"cordis-european-research-council-award-740349","Transcriptional control of plasma cell development and function","Antibody-secreting cells consisting of short-lived proliferating plasmablasts and long-lived quiescent plasma cells are essential for the acute response to infection and long-term protection of the host against pathogens. Only a few regulators (Blimp1, IRF4, XBP1, Aiolos, Ikaros and E-proteins) have been implicated in the transcriptional control of antibody-secreting cells, and their target genes, with the exception of Blimp1 and E-proteins, are still unknown. This proposal aims to systematicall",{"id":1011,"funder":7,"programme":8,"title":1012,"piName":14,"institution":288,"country":69,"year":13,"amount":1013,"abstract":1014},"cordis-european-research-council-award-740696","Soundscape Indices","€2,492,201","Eighty million EU citizens are suffering from excessive environmental noise and billions of euros are being spent on noise control, under the EU Directive on Environmental Noise. Unfortunately, the conventional approach, i.e. reduction of ‘sound level’, simply does not deliver the required improvements in quality of life. The growing field of ‘soundscape studies’ is addressing this gap by considering sound environment as perceived, in context, with an interdisciplinary approach. However, soundsc",{"id":1016,"funder":7,"programme":8,"title":1017,"piName":14,"institution":703,"country":141,"year":13,"amount":1018,"abstract":1019},"cordis-european-research-council-award-788001","Global Governance through Goals? Assessing and Explaining the Steering Effects  of the United Nations Sustainable Development Goals","€2,493,750","Achieving sustainable development worldwide remains probably the biggest political challenge of our time. In 2015, the international community adopted 17 'Sustainable Development Goals' with no less than 169 ‘targets’ as part of a global '2030 Agenda for Sustainable Development'. The ambition expressed in these goals is unprecedented. But can such goal-setting, as a new central approach in global governance, help resolve the pressing challenges of economic development, poverty eradication, socia",{"id":1021,"funder":7,"programme":8,"title":1022,"piName":14,"institution":357,"country":69,"year":13,"amount":1023,"abstract":1024},"cordis-european-research-council-award-788508","In vitro high resolution reconstitution of autophagosome nucleation and expansion catalyzed by ATG9","€2,121,055","Autophagy is a conserved, lysosomal-mediated pathway required for cell homeostasis and survival. It is controlled by the master regulators of energy (AMPK) and growth (TORC1) and mediated by the ATG (autophagy) proteins. Deregulation of autophagy is implicated in cancer, immunity, infection, aging and neurodegeneration. Autophagosomes form and expand using membranes from the secretory and endocytic pathways but how this occurs is not understood. ATG9, the only transmembrane ATG protein traffics ",{"id":1026,"funder":7,"programme":8,"title":1027,"piName":14,"institution":213,"country":214,"year":13,"amount":1028,"abstract":1029},"cordis-european-research-council-award-788009","Iron mineral dynamics in redox-affected soils and sediments: Pushing the frontier toward in-situ studies","€3,154,658","IRMIDYN will study the dynamics of redox-driven iron mineral transformation processes in soils and sediments and impacts on nutrient and trace element behavior using a novel approach based on enriched stable isotopes (e.g., 57Fe, 33S, 67Zn, 113Cd, 198Hg) in combination with innovative experiments and cutting-edge analytical techniques, most importantly 57Fe Mössbauer and Raman micro-spectroscopy and imaging. The thermodynamic stability and occurrence of iron minerals in sufficiently stable Earth",{"id":1031,"funder":7,"programme":8,"title":1032,"piName":14,"institution":1033,"country":214,"year":13,"amount":1034,"abstract":1035},"cordis-european-research-council-award-787886","Cosmology with Strong Gravitational Lensing","ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE","€3,129,689","Measuring cosmological distances has revolutionized our understanding of the Universe, and is still doing so! Early work in the 1920s led to the discovery of the expansion of the Universe. More precise distance measurements in the 90s with type-Ia supernovae revealed that this expansion is accelerating, with crucial consequences in cosmology and physics. Is the acceleration due to some repulsive form of dark energy? To Einstein's cosmological constant? Do we need to consider new physics? Answeri",{"id":1037,"funder":7,"programme":8,"title":1038,"piName":14,"institution":1039,"country":34,"year":13,"amount":1040,"abstract":1041},"cordis-european-research-council-award-788368","ACelerated COnvex OPTimization","UNIVERSITE CATHOLIQUE DE LOUVAIN","€2,090,038","The amazing rate of progress in the computer technologies and telecommunications presents many new challenges for Optimization Theory. New problems are usually very big in size, very special in structure and possibly have a distributed data support. This makes them unsolvable by the standard optimization methods. In these situations, old theoretical models, based on the hidden Black-Box information, cannot work. New theoretical and algorithmic solutions are urgently needed. In this project we wi",{"id":1043,"funder":7,"programme":8,"title":1044,"piName":14,"institution":232,"country":125,"year":13,"amount":1045,"abstract":1046},"cordis-european-research-council-award-789373","Foundations for Fair Social Computing","€2,487,500","Social computing represents a societal-scale symbiosis of humans and computational systems, where humans interact via and with computers, actively providing inputs to influence and being influenced by, the outputs of the computations. Recently, several concerns have been raised about the unfairness of social computations pervading our lives ranging from the potential for discrimination in machine learning based predictive analytics and implicit biases in online search and recommendations to thei",{"id":1048,"funder":7,"programme":8,"title":1049,"piName":14,"institution":153,"country":34,"year":13,"amount":1050,"abstract":1051},"cordis-european-research-council-award-788506","Commonsense and Anticipation enriched Learning of Continuous representations sUpporting Language UnderStanding","€2,227,500","Natural language understanding (NLU) by the machine is of large scientific, economic and social value. Humans perform the NLU task in an efficient way by relying on their capability to imagine or anticipate situations. They engage commonsense and world knowledge that is often acquired through perceptual experiences to make explicit what is left implicit in language. Inspired by these characteristics CALCULUS will design, implement and evaluate innovative paradigms supporting NLU, where it will c",{"id":1053,"funder":7,"programme":8,"title":1054,"piName":14,"institution":902,"country":27,"year":13,"amount":1055,"abstract":1056},"cordis-european-research-council-award-788247","General compliant aerial Robotic manipulation system Integrating Fixed and Flapping wings to INcrease range and safety","€2,499,750","The goal of GRIFFIN is the derivation of a unified framework with methods, tools and technologies for the development of flying robots with dexterous manipulation capabilities. The robots will be able to fly minimizing energy consumption, to perch on curved surfaces and to perform dexterous manipulation. Flying will be based on foldable wings with flapping capabilities. They will be able to safely operate in sites where rotorcrafts cannot do it and physically interact with people.  Dexterous man",{"id":1058,"funder":7,"programme":8,"title":1059,"piName":14,"institution":1060,"country":69,"year":13,"amount":1061,"abstract":1062},"cordis-european-research-council-award-788968","Dynamic Control of Mineralisation","UNIVERSITY OF LEEDS","€2,632,375","This project will take inspiration from biomineralisation to achieve exceptional, dynamic control over crystallisation processes.  Understanding the fundamental mechanisms which govern crystallisation promises the ability to inhibit or promote crystallisation as desired, and to tailor the properties of crystalline materials towards a huge range of applications. Biomineralisation provides a perfect precedent for this approach, where organisms achieve control currently unparalleled in synthetic sy",{"id":1064,"funder":7,"programme":8,"title":1065,"piName":14,"institution":68,"country":69,"year":13,"amount":1066,"abstract":1067},"cordis-european-research-council-award-787887","Banks, Popular Backlash, and the Post-Crisis Politics of Financial Regulation","€2,454,198","Driven by public outrage at bank bailouts during the financial crisis, many governments have since then tried to rewrite the rules governing finance. Yet the anger provoked by the bailouts has not subsided. In Europe and in North America, citizen fury against bankers continues to structure battles over financial regulation. It also affects broader perceptions of fairness in the political system and feeds anti-elite populism. Scholars of political economy have chronicled the clashes between state",{"id":1069,"funder":7,"programme":8,"title":1070,"piName":14,"institution":147,"country":125,"year":13,"amount":1071,"abstract":1072},"cordis-european-research-council-award-788941","Unlimited Growth? A Comparative Analysis of Causes and Consequences of Policy Accumulation","€2,359,000","ACCUPOL systematically analyzes an intuitively well-known, but curiously under-researched phenomenon: policy accumulation. Societal modernization and progress bring about a continuously growing pile of policies in most political systems. At the same time, however, the administrative capacities for implementation are largely stagnant. While being societally desirable in principle, ever-more policies hence may potentially imply less in terms of policy achievements. Whether or not policy accumulati",{"id":1074,"funder":7,"programme":8,"title":1075,"piName":14,"institution":1033,"country":214,"year":13,"amount":1076,"abstract":1077},"cordis-european-research-council-award-788587","Bio-mediated Geo-material Strengthening for engineering applications","€2,497,115","Given the increasing scarcity of suitable land for development, soil strengthening technologies have emerged in the past decade and go hand-in-hand with the implementation of the majority of foundation solutions. The goal is to alter the soil structure and its mechanical properties for ultimately securing the integrity of structures. The BIOGEOS project puts the focus on bio-mediated soil improvement, which falls within the broader framework of multi-physical processes in geo-mechanics. The goal",{"id":1079,"funder":7,"programme":8,"title":1080,"piName":14,"institution":1033,"country":214,"year":13,"amount":102,"abstract":1081},"cordis-european-research-council-award-787702","The Mitochondrial Unfolded Protein Response","Mitochondria—organelles specialized in energy harvesting through oxidative phosphorylation (Oxphos)—critically influence metabolism, health and lifespan. Evolved from endosymbiotic proteobacteria, mitochondria retained the vestige of the bacterial genome, the mitochondrial DNA, which encodes 13 subunits of the Oxphos complexes, while the remaining ~80 Oxphos components and the rest of the mitochondrial proteome are encoded on nuclear DNA, translated in the cytoplasm and imported in the mitochond",{"id":1083,"funder":7,"programme":8,"title":1084,"piName":14,"institution":1033,"country":214,"year":13,"amount":1085,"abstract":1086},"cordis-european-research-council-award-788697","High-Throughput Cryogenic Spectroscopy for Glycan Analysis","€2,499,801","Glycans, or oligosaccharides, are ubiquitous in biological systems. Because they decorate the surface of cells, they play a key role in virtually all cellular recognition processes and are implicated in almost every major disease.  Despite their importance, the characterization of glycan primary structure lags far behind that of proteins and DNA because of their intrinsic isomeric complexity. The isomeric nature of the monosaccharide building blocks, the stereochemistry of the glycosidic bond, t",{"id":1088,"funder":7,"programme":8,"title":1089,"piName":14,"institution":1090,"country":21,"year":13,"amount":1091,"abstract":1092},"cordis-european-research-council-award-788482","Molecules under Light-Matter Strong Coupling","CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION","€2,468,750","When molecules or molecular materials are placed in the confined field of an optical mode which is resonant with a molecular transition, new hybrid light-matter states can be formed through strong coupling. This can occur even in the dark due to strong coupling with the vacuum electromagnetic field.  The hybrid light-matter states are collective states involving a large number of molecules and they strongly modify the energy levels of the system. While light-matter strong coupling has been exten",{"id":1094,"funder":7,"programme":8,"title":1095,"piName":14,"institution":1096,"country":125,"year":13,"amount":1097,"abstract":1098},"cordis-european-research-council-award-788381","Deep BIOmodeling of human CARDiogenesis","KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)","€2,285,625","The heart is one of the first and most complex organs formed during human embryogenesis. While its anatomy and physiology have been extensively studied over centuries, the normal development of human heart and dysregulation in disease still remain poorly understood at the molecular\u002Fcellular level. Stem cell technologies hold promise for modelling development, analysing disease mechanisms, and developing potential therapies. By combining multidisciplinary approaches centred on human induced pluri",{"id":1100,"funder":7,"programme":8,"title":1101,"piName":14,"institution":1102,"country":249,"year":13,"amount":102,"abstract":1103},"cordis-european-research-council-award-787534","Nanoscale Biomeasurements of Nerve Cells and Vesicles: Molecular Substructure and the Nature of Exocytosis","GOETEBORGS UNIVERSITET","I propose to develop and apply state of the art analytical methods to investigate cell membrane and vesicle substructure to elucidate the chemistry of the closing regulatory phase of individual exocytosis events. The general goal of this proposal is to develop a new brand of analytical nanoelectrochemistry (nanogap and nanopore electrochemical cytometry), combined with chemical nanoscopy imaging methods with STED and nanoscale mass spectrometry imaging.  I propose to apply this to the questions ",{"id":1105,"funder":7,"programme":8,"title":1106,"piName":14,"institution":1107,"country":125,"year":13,"amount":1108,"abstract":1109},"cordis-european-research-council-award-788380","Local Edaphic Adaptation in Plants through Leveraging an Extremophile Model","RUHR-UNIVERSITAET BOCHUM","€2,498,675","The discontinuous mosaic of soil compositions on the Earth’s changeable surface intermittently requires the adaptation of plants as crucial mediators for ecosystems with the inorganic lithosphere harbouring all nutrient, but also toxic minerals. Only few gene variants have been implicated in local soil adaptation. There is a general lack of information about their relation with soil composition in the field, the manner in which such adaptations function and evolve, and why they arise in some tax",200,{"programme":8,"total":1112,"withPiName":1113,"firstYear":1114,"lastYear":1115,"countryCount":1116,"perYear":1117,"topInstitutions":1174,"topCountries":1245},4756,450,2008,2027,46,[1118,1120,1123,1126,1129,1132,1135,1138,1141,1144,1146,1148,1151,1154,1157,1160,1163,1166,1169,1172],{"year":1114,"count":1119},47,{"year":1121,"count":1122},2009,232,{"year":1124,"count":1125},2010,248,{"year":1127,"count":1128},2011,276,{"year":1130,"count":1131},2012,293,{"year":1133,"count":1134},2013,344,{"year":1136,"count":1137},2014,359,{"year":1139,"count":1140},2015,138,{"year":1142,"count":1143},2016,299,{"year":1145,"count":1122},2017,{"year":13,"count":1147},376,{"year":1149,"count":1150},2019,241,{"year":1152,"count":1153},2020,137,{"year":1155,"count":1156},2021,228,{"year":1158,"count":1159},2022,322,{"year":1161,"count":1162},2023,252,{"year":1164,"count":1165},2024,243,{"year":1167,"count":1168},2025,222,{"year":1170,"count":1171},2026,264,{"year":1115,"count":1173},3,[1175,1178,1181,1184,1187,1190,1193,1196,1199,1202,1205,1208,1211,1214,1217,1220,1223,1226,1228,1231,1233,1235,1237,1240,1242],{"name":1176,"count":1177},"Centre National de la Recherche Scientifique CNRS",206,{"name":1179,"count":1180},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",133,{"name":1182,"count":1183},"University of Oxford",128,{"name":1185,"count":1186},"University of Cambridge",124,{"name":1188,"count":1189},"Eidgenoessische Technische Hochschule Zuerich",84,{"name":1191,"count":1192},"Weizmann Institute of Science",74,{"name":1194,"count":1195},"École Polytechnique Fédérale de Lausanne",72,{"name":1197,"count":1198},"University College London",69,{"name":1200,"count":1201},"Ludwig-Maximilians-Universitaet Muenchen",59,{"name":1203,"count":1204},"The Hebrew University of Jerusalem",57,{"name":1206,"count":1207},"Katholieke Universiteit Leuven",52,{"name":1209,"count":1210},"University of Bristol",49,{"name":1212,"count":1213},"University of Edinburgh",48,{"name":1215,"count":1216},"Kobenhavns Universitet",40,{"name":1218,"count":1219},"Universiteit van Amsterdam",39,{"name":1221,"count":1222},"Institut National de la Sante Et de la Recherche Medicale",38,{"name":1224,"count":1225},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",35,{"name":1227,"count":1225},"Tel Aviv University",{"name":1229,"count":1230},"Imperial College of Science Technology and Medicine",33,{"name":1232,"count":1230},"Technische Universitaet Muenchen",{"name":1234,"count":1230},"Universitat Wien",{"name":1236,"count":1230},"University of Manchester",{"name":1238,"count":1239},"Helsingin Yliopisto",32,{"name":1241,"count":1239},"Karolinska Institutet",{"name":1243,"count":1244},"Technische Universiteit Delft",30,[1246,1248,1250,1252,1254,1256,1258,1260,1262,1264,1266,1267,1269,1271,1273,1275,1277,1279,1281,1284,1287,1290,1292,1293,1296],{"name":125,"count":1247},802,{"name":69,"count":1249},778,{"name":21,"count":1251},581,{"name":141,"count":1253},390,{"name":214,"count":1255},310,{"name":112,"count":1257},302,{"name":27,"count":1259},269,{"name":602,"count":1261},202,{"name":249,"count":1263},183,{"name":322,"count":1265},153,{"name":34,"count":1265},{"name":62,"count":1268},107,{"name":12,"count":1270},78,{"name":595,"count":1272},76,{"name":227,"count":1274},65,{"name":864,"count":1276},42,{"name":1278,"count":1216},"PT",{"name":190,"count":1280},25,{"name":1282,"count":1283},"EL",24,{"name":1285,"count":1286},"US",20,{"name":1288,"count":1289},"PL",18,{"name":823,"count":1291},15,{"name":975,"count":1291},{"name":1294,"count":1295},"CN",9,{"name":1297,"count":1298},"EE",8]