[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-advanced-grant-2019":3,"awarded-stats-erc-advanced-grant":1102},{"awarded":4,"total":1101},[5,16,23,30,36,42,48,53,59,65,71,78,83,88,93,98,104,111,117,123,128,133,138,144,148,154,159,164,170,175,180,184,189,194,198,203,208,213,218,223,230,236,241,246,252,258,265,270,276,283,289,295,301,308,315,322,328,334,341,347,353,359,366,371,376,382,388,394,400,406,412,418,424,429,434,439,444,449,455,460,465,470,475,481,486,492,497,503,509,514,520,525,530,535,540,545,550,556,562,568,574,578,583,587,593,598,604,610,615,620,625,630,636,642,647,651,656,661,666,671,677,682,687,693,699,703,708,714,720,725,731,738,743,749,755,761,767,772,777,783,789,796,801,807,813,818,823,829,835,840,845,851,856,861,866,872,877,882,888,893,898,903,909,913,918,923,927,931,936,940,944,949,954,958,963,969,975,981,987,991,996,1001,1006,1012,1018,1022,1028,1033,1039,1044,1050,1056,1060,1065,1070,1075,1080,1085,1091,1097],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-834221","European Research Council","ERC Advanced Grant","The Roots of Infection",null,"AARHUS UNIVERSITET","DK",2019,"€2,499,999","Plant roots and soil microbes have been associated since the emergence of plants on land. Nevertheless the mechanisms that have coevolved to control these commensal and mutualistic associations are currently unknown. RINFEC will identify both plant and bacterial genes involved in root colonization by commensal and mutualistic bacteria with an approach that would be transformative in the field. The ambitious challenge is to identify and functionally characterize the central genes controlling root",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":20,"year":13,"amount":21,"abstract":22},"cordis-european-research-council-award-834756","Science and technology for the explanation of AI decision making","SCUOLA NORMALE SUPERIORE","IT","€2,500,000","A wealthy friend of mine asks for a vacation credit card to his bank, to discover that the credit he is offered is very low. The bank teller cannot explain why. My stubborn friend continues his quest for explanation up to the bank executives, to discover that an algorithm lowered his credit score. Why? After a long investigation, it turns out that the reason is: bad credit by the former owner of my friends house.Black box AI systems for automated decision making, often based on ML over (big) dat",{"id":24,"funder":7,"programme":8,"title":25,"piName":10,"institution":26,"country":27,"year":13,"amount":28,"abstract":29},"cordis-european-research-council-award-833849","Information structures in consumer markets","UNIVERSITY COLLEGE LONDON","UK","€1,221,744","Information flows are fundamental to how well markets work for consumers and firms. Consumers get different deals depending on (a) how much they know about the offerings of different firms and, conversely, (b) how much firms know about consumer preferences. The internet is transforming both (a) and (b), allowing consuInformation flows are fundamental to how well markets work for consumers and firms. Consumers get different deals depending on (a) how much they know about the offerings of differen",{"id":31,"funder":7,"programme":8,"title":32,"piName":10,"institution":33,"country":27,"year":13,"amount":34,"abstract":35},"cordis-european-research-council-award-833713","Mechanism of Type 9 Secretion: an unusual protein transport system involved in pathogenesis and motility","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€2,245,365","The recently-discovered Type IX Secretion System (T9SS) is a protein transport pathway that exports proteins across the outer membrane of Gram-negative of the phylum Bacteroidetes. It is an essential pathogenicity determinant in severe periodontal disease and in the major bacterial diseases of farmed fish. It is also required for the unique Bacteroidete gliding motility. The components required to catalyse T9SS export are still not fully defined, but include at least 18 authenticated proteins. P",{"id":37,"funder":7,"programme":8,"title":38,"piName":10,"institution":39,"country":20,"year":13,"amount":40,"abstract":41},"cordis-european-research-council-award-834615","Synthetic photobiology for light controllable active matter","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","€2,397,500","From a Physics and Engineering standpoint, swimming bacteria are a formidable example of self-propelled micro-machines. Together with their synthetic counterpart, self-propelled colloids, they represent the “living” atoms of active matter, an exciting branch of contemporary soft matter and statistical mechanics. Differently from synthetic colloids, however, each bacterial cell contains all the molecular machinery that is required to self-replicate, sense the environment, process information and ",{"id":43,"funder":7,"programme":8,"title":44,"piName":10,"institution":45,"country":46,"year":13,"amount":21,"abstract":47},"cordis-european-research-council-award-785917","HARNESSING PML NUCLEAR BODIES FOR LEUKAEMIA THERAPY","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","FR","In acute promyelocytic leukaemia (APL), retinoic acid (RA) and Arsenic trioxide (As) bind PML\u002FRARA and promote its degradation. Exploring the mechanistic bases for APL response to the RA\u002FAs combination, we found that upon PML\u002FRARA degradation the normal PML allele activates a PML\u002FP53 checkpoint absolutely required for APL cure in mice or patients. Physiologically, PML behaves as an oxidative stress sensor and contributes to redox homeostasis. PML organizes nuclear bodies (NBs), domains that recr",{"id":49,"funder":7,"programme":8,"title":50,"piName":10,"institution":45,"country":46,"year":13,"amount":51,"abstract":52},"cordis-european-research-council-award-834161","Targeting endothelial barriers to combat disease","€2,499,969","Tissue homeostasis requires coordinated barrier function in blood and lymphatic vessels. Opening of junctions between endothelial cells (ECs) lining blood vessels leads to tissue fluid accumulation that is drained by lymphatic vessels. A pathological increase in blood vessel permeability or lack or malfunction of lymphatic vessels leads to edema and associated defects in macromolecule and immune cell clearance. Unbalanced barrier function between blood and lymphatic vessels contributes to neurod",{"id":54,"funder":7,"programme":8,"title":55,"piName":10,"institution":56,"country":46,"year":13,"amount":57,"abstract":58},"cordis-european-research-council-award-788191","Assessing, preserving and restoring man-microbes symbiosis","INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT","€2,491,014","The microbiomics revolution has favoured the recognition of the gut as a true organ and the importance of man-microbes symbiosis in health and disease. Derived from a long co-evolution the latter has been challenged by numerous environmental triggers, modern lifestyles, changes in birth modalities, nutritional transition and therapeutic attitudes. A large fraction of the human population has tentatively entered a man-microbes dysbiotic state characterized by altered interactions between microbio",{"id":60,"funder":7,"programme":8,"title":61,"piName":10,"institution":62,"country":46,"year":13,"amount":63,"abstract":64},"cordis-european-research-council-award-835275","Modeling the past climates of planet Mars to understand its geology, its habitability and its evolution","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€2,493,836","Over the past decades, the robotic exploration of the planet Mars has produced a wealth of geological observations. They show that Mars has not always been the desert planet of today. It has seen eras conducive to rivers and lakes, ice ages, and even periods with a collapsed atmosphere. These different epochs are the reason why Mars remains the objective of space agencies, as they evoke the possibility of past habitability and spectacular climate changes.Yet, in spite of all the data, the climat",{"id":66,"funder":7,"programme":8,"title":67,"piName":10,"institution":68,"country":20,"year":13,"amount":69,"abstract":70},"cordis-european-research-council-award-833647","Computable  Law","ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA","€2,273,550","The project addresses the regulation of computations (processes and systems) through an innovative legal & technological framework: it provides epistemic, technical and normative guidance for the de-velopment of computable laws and law compliant computations. The context is the ongoing transformation of the social world into a hybrid infosphere, populated by a huge and growing number of increasingly pervasive, autonomous and intelligent computational enti-ties. The scale, speed, ubiquity and aut",{"id":72,"funder":7,"programme":8,"title":73,"piName":10,"institution":74,"country":75,"year":13,"amount":76,"abstract":77},"cordis-european-research-council-award-834162","Novel roles of dimethylated sulphur in marine microbial interactions","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","ES","€2,499,187","Sulphur is an essential element for life that cycles rapidly in the pelagic ocean in the form of biogenic dimethylated compounds. Over three decades, dimethylated sulphur has been intensively investigated for its emission to the atmosphere and its suggested roles in returning sulphur to continents and in climate regulation. While the climate connection still awaits definitive confirmation or denial, these research efforts have provided important advances in plankton physiology and ecology, since",{"id":79,"funder":7,"programme":8,"title":80,"piName":10,"institution":74,"country":75,"year":13,"amount":81,"abstract":82},"cordis-european-research-council-award-788582","Early conditions, delayed adult effects and morbidity, disability and mortality in modern human populations","€2,852,655","This project aims to reformulate and generalize standard theories of human health and mortality. It proposes new formal models and a systematic agenda to empirically test hypotheses that link developmental biology, epigenetics and adult human illness, disability and mortality. We seek to break new ground developing innovative formal models for illnesses and mortality, testing new hypotheses about the evolution of human health and, to the extent permitted by findings, reformulating standard theor",{"id":84,"funder":7,"programme":8,"title":85,"piName":10,"institution":33,"country":27,"year":13,"amount":86,"abstract":87},"cordis-european-research-council-award-835079","Chronotype, health and family: The role of biology, socio- and natural environment and their interaction","€2,499,811","The widespread use of electronic devices, artificial light and rise of the 24-hour economy means that more individuals experience disruption of their chronotype, which is the natural circadian rhythm that regulates sleep and activity levels. The natural and medical sciences focus on the natural environment (e.g., light exposure), genetics, biology and health consequences, whereas the social sciences have largely explored the socio-environment (e.g., working regulations) and psychological and fam",{"id":89,"funder":7,"programme":8,"title":90,"piName":10,"institution":33,"country":27,"year":13,"amount":91,"abstract":92},"cordis-european-research-council-award-834228","White-Box Self-Programming Mechanisms","€2,499,197","We are witnessing an increasing availability of mechanisms that operate in nondeterministic (uncertain) environments and offer some form of programmability. These include manufacturing devices, smart objects and spaces, intelligent robots, dynamic business process management systems, and many others. All these mechanisms are currently being revolutionized by advancements in sensing (vision, language understanding) and actuation components (autonomous mobile manipulators, automated storage and re",{"id":94,"funder":7,"programme":8,"title":95,"piName":10,"institution":33,"country":27,"year":13,"amount":96,"abstract":97},"cordis-european-research-council-award-788932","MILLIKELVIN VISUALISATION OF TOPOLOGICAL ORDER","€3,499,176","The urgent imperative to discover and understand topological quantum matter (TQM) is based both on the fundamental significance of its rich new physics and on the potential for unprecedented applications e.g. topological quantum computing. Specific topological ordered states, such as topological superconductors, ferromagnetic topological insulators, and topological Kondo insulators, are now the focus of physics research. Their microscopic quantum states have proven very difficult to address expe",{"id":99,"funder":7,"programme":8,"title":100,"piName":10,"institution":101,"country":27,"year":13,"amount":102,"abstract":103},"cordis-european-research-council-award-834514","The End of the Journey: The Late Pleistocene-Early Holocene Colonisation of South America","THE UNIVERSITY OF EXETER","€2,498,590","Understanding the human journey of global colonisation is the history of modern humanity and the development of the diverse characteristics of peoples and cultures around the world. This five-year interdisciplinary project will investigate the peopling of South America, the last continental terra incognita (other than Antarctica) to be colonised by humans, constituting a virtually unprecedented migration of modern humans across richly diverse, empty landscapes during the Late Pleistocene-Early H",{"id":105,"funder":7,"programme":8,"title":106,"piName":10,"institution":107,"country":108,"year":13,"amount":109,"abstract":110},"cordis-european-research-council-award-833710","Exploiting the Tumor Proteome Activity Status for Future Cancer Therapies","TECHNISCHE UNIVERSITAET MUENCHEN","DE","€2,272,055","Kinases are key regulators of protein activity and phosphorylate thousands of proteins in cells. The phosphoproteome can hence be viewed as a proxy for the proteome activity status of a cell. Dysregulation of the phosphoproteome can cause diseases such as cancer. As a result, kinase inhibitors have become important drugs in oncology and nearly 50 are approved for use in humans. As they typically have a range of targets, there is enormous potential for repurposing these drugs for other cancer ent",{"id":112,"funder":7,"programme":8,"title":113,"piName":10,"institution":114,"country":108,"year":13,"amount":115,"abstract":116},"cordis-european-research-council-award-835284","Modal Nonlinear Resonance for Efficient and Versatile Legged Locomotion","DEUTSCHES ZENTRUM FUR LUFT - UND RAUMFAHRT EV","€2,491,884","The aim of M-Runners is to thoroughly advance the understanding of fundamental dynamic principles of legged locomotion to the point that those principles can be used to design robots which display similar motion characteristics, versatility, and efficiency as their biological paragons. The central hypothesis of the project is that biological locomotion is fundamentally determined by the mechanical resonance properties of the body and that a breakthrough in robot locomotion is essentially linked ",{"id":118,"funder":7,"programme":8,"title":119,"piName":10,"institution":120,"country":27,"year":13,"amount":121,"abstract":122},"cordis-european-research-council-award-835271","Rome Transformed: Interdisciplinary analysis of political, military and religious regenerations of the city's forgotten quarter C1-C8 CE","UNIVERSITY OF NEWCASTLE UPON TYNE","€2,425,684","This project revolutionises our understanding of Rome and its place in cultural change across the Mediterranean World by mapping political, military and religious changes to the Eastern Caelian from the first to eighth centuries.  The programme offers multiple gains for archaeologists, historians, topographers and geographers by documenting both the mundane and monumental elements of the city fabric in chronological, geographical and ideological relationship to one another. From the extravagant ",{"id":124,"funder":7,"programme":8,"title":125,"piName":10,"institution":62,"country":46,"year":13,"amount":126,"abstract":127},"cordis-european-research-council-award-787539","GEnerating extreme NEutrons for achieving controlled r-process nucleosyntheSIS","€3,494,784","The project aim is to perform the first direct measurements of neutron capture and beta-decay rates related to the “r-process” of nucleosynthesis. This process, based on squeezing at once multiple neutrons in a nucleus, is presently thought to be the main mechanism that forms the heaviest elements in our Solar System and in stars. At present, there are large discrepancies between the observed element abundances in stars and those found from simulations. It is speculated that this problem stems f",{"id":129,"funder":7,"programme":8,"title":130,"piName":10,"institution":62,"country":46,"year":13,"amount":131,"abstract":132},"cordis-european-research-council-award-834148","Accelerating Galactic Archaeology","€2,472,738","Why most of the matter in the Universe appears to be dark, and constituted of some unknown particles, is one of the most important open questions in physics today. Here we propose to investigate the relative merits of different possibilities for the nature of this dark matter, as well as alternative proposals for the nature of the gravitational interaction, by comparing their predictions to new high spatial resolution measurements of the 3D acceleration field in the Milky Way.  These measurement",{"id":134,"funder":7,"programme":8,"title":135,"piName":10,"institution":62,"country":46,"year":13,"amount":136,"abstract":137},"cordis-european-research-council-award-832248","Simulation and Control of Renewable COmbustion (SCIROCCO)","€2,495,335","Most renewable energies can only be delivered intermittently. Without massive long-term storage capacities they will never provide 65 % of our energy mix by 2050, as required to limit global warming to 2°. Throughout this period and beyond, energy generation from combustion will remain a key component of this mix. SCIROCCO has two goals: (1) provide effective storage for renewable energies and (2) significantly improve existing combustion systems.  Objective (1) is addressed by extending ‘Power ",{"id":139,"funder":7,"programme":8,"title":140,"piName":10,"institution":141,"country":27,"year":13,"amount":142,"abstract":143},"cordis-european-research-council-award-788960","COSMOS: Computational Shaping and Modeling of Musical Structures","KING'S COLLEGE LONDON","€2,495,776","Music performance is considered by many to be one of the most breath taking feats of human intelligence. That music performance is a creative act is no longer a disputed fact, but the very nature of this creative work remains illusive. Taking the view that the creative work of performance is the making and shaping of music structures, and that this creative thinking is a form of problem solving, COSMOS proposes an integrated programme of research to transform our understanding of the human exper",{"id":145,"funder":7,"programme":8,"title":146,"piName":10,"institution":62,"country":46,"year":13,"amount":21,"abstract":147},"cordis-european-research-council-award-835184","Deciphering the molecular mechanisms of HIV DNA nuclear import and the impact of 3D genome organization on integration site selection","Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects DNA functions, primarily transcription. During retroviral infection, histone-free viral DNA copy is synthesized from viral genomic RNA. vDNA will ultimately integrate into the host genome to ensure its maintenance and expression.  Understanding retrovirus-host interactions at the genomic level, and the peculiar mechanisms by ",{"id":149,"funder":7,"programme":8,"title":150,"piName":10,"institution":151,"country":27,"year":13,"amount":152,"abstract":153},"cordis-european-research-council-award-834455","Labour Policies for Inclusive Growth","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","€2,175,289","Most advanced economies have struggled to deliver inclusive growth in recent decades. Many people are fearful about the impact on their lives of technological change, large-scale immigration, and a shifting balance of power in the labour market that seems to have benefitted employers at the expense of workers. There is a widening gap in economic fortunes between ex-industrial areas and dynamic cities with service-based economies. The stakes are high: we should not be surprised if some voters no ",{"id":155,"funder":7,"programme":8,"title":156,"piName":10,"institution":151,"country":27,"year":13,"amount":157,"abstract":158},"cordis-european-research-council-award-835002","Genetically Evolving Models of Science","€2,182,339","The development of scientific models suffers from two related problems: ever-growing number of experimental results and scientists’ cognitive limitations (including cognitive biases). This multidisciplinary project (psychology, computer modelling, computer science and cognitive neuroscience) addresses these problems by developing a novel methodology for generating scientific models automatically. The methodology is general and can be applied to any science where experimental data are available. ",{"id":160,"funder":7,"programme":8,"title":161,"piName":10,"institution":62,"country":46,"year":13,"amount":162,"abstract":163},"cordis-european-research-council-award-788077","Sources of Meaning: Grounding Formal Semantics","€2,499,416","While formal semantics has established itself as a rigorous field, its impact on the broader cognitive sciences has remained suboptimal. Besides the inherent complexity of formal theories, the reason might be that the data explained are narrowly linguistic. We propose to extend the breadth and explanatory depth of formal semantic theories by testing them against understudied objects. Within language, we study spoken language gestures as well as sign languages, especially in their iconic dimensio",{"id":165,"funder":7,"programme":8,"title":166,"piName":10,"institution":167,"country":168,"year":13,"amount":10,"abstract":169},"cordis-european-research-council-award-834513","The circadian clock in day-active species: preserving our health in modern society","ACADEMISCH ZIEKENHUIS LEIDEN","NL","Due to a significant increase in the use of artificial light in our 24h economy, the biological clocks of all living organisms, including humans, are severely disrupted. Many severe health disorders are consequences of clock disruption such as diabetes, sleep\u002Fmood disorders, cardiovascular disease, and immune dysfunction. The central timekeeper in mammals is the suprachiasmatic nucleus (SCN), and the mechanisms by which light disrupts integrity of the SCN has been well investigated in nocturnal ",{"id":171,"funder":7,"programme":8,"title":172,"piName":10,"institution":62,"country":46,"year":13,"amount":173,"abstract":174},"cordis-european-research-council-award-835067","Untangling eco-evolutionary impacts on diatom genomes over timescales relevant to current climate change","€2,495,753","Diatoms are major contributors of primary production in the ocean and participate in carbon sequestration over geologically relevant timescales. As key components of the Earth’s carbon cycle and marine food webs we need to understand the eco-evolutionary underpinnings of their ecological success to forecast their fate in a future ocean impacted by anthropogenic change. Genomes and epigenomes from model diatoms, as well as hundreds of transcriptomes from multiple species, have revealed genetic an",{"id":176,"funder":7,"programme":8,"title":177,"piName":10,"institution":62,"country":46,"year":13,"amount":178,"abstract":179},"cordis-european-research-council-award-787340","Dynamic mechanisms and functional roles of synaptic plasticity in memory","€2,499,505","Activity-dependent plasticity of synaptic transmission together with refinement of neural circuits connectivity are amongst the core mechanisms underlying learning and memory. While there is already extensive knowledge on some of the mechanisms of synaptic plasticity, fundamental questions remain on the dynamics of the underlying molecular events and the functional roles of various forms of synaptic plasticity in information processing, learning and behavior.We previously uncovered basic feature",{"id":181,"funder":7,"programme":8,"title":182,"piName":10,"institution":62,"country":46,"year":13,"amount":10,"abstract":183},"cordis-european-research-council-award-789111","Human motivation: evolutionary foundations and their implications for economics","Economics provides decision-makers with powerful tools to analyse a wide range of issues. The methodological unity of the discipline and its quest for a general understanding of market as well as non-market interactions have given the discipline great influence on policy. A core component of economics is its assumption that individuals act as if they each had some goal function that they seek to maximise, under the constraints they face and the information they have.Despite significant advances ",{"id":185,"funder":7,"programme":8,"title":186,"piName":10,"institution":62,"country":46,"year":13,"amount":187,"abstract":188},"cordis-european-research-council-award-788974","Signal transduction and allosteric modulation of nicotinic acetylcholine receptors: from ion channel electrophysiology to atomic 3D structures","€2,282,105","Nicotinic acetylcholine receptors (nAChRs) mediate neuronal synaptic transmission and modulation. They contribute to higher brain functions such as cognition and reward and are important drug targets. Recent studies have revealed that these acetylcholine-gated ion channels display an unanticipated conformational plasticity, adopting multiple allosteric states that shape the time course of their electrophysiological response. To date, a single nAChR structure has been solved at high resolution, a",{"id":190,"funder":7,"programme":8,"title":191,"piName":10,"institution":62,"country":46,"year":13,"amount":192,"abstract":193},"cordis-european-research-council-award-832889","Integration of new nano-engineered safe energetic layers with Sensors and Electronics to manufacture Safety-Critical Microsystems","€2,499,853","PyroSafe aims at (1) creating a new generation of safe and versatile energetic materials with tailored architectures at nanoscales to replace old unsafe energetic substances currently used in pyrodevices; (2) enabling a new technology based on the co-integration of electronic components with these new types of energetic layers; (3) manufacturing high energetic microsystems able to produce multiple functionalities (gas, heat, or generation of chemical species) to implement relevant emergency safe",{"id":195,"funder":7,"programme":8,"title":196,"piName":10,"institution":62,"country":46,"year":13,"amount":21,"abstract":197},"cordis-european-research-council-award-832352","Testing new hypotheses on the evolution  of sex-related chromosomes","The sex chromosomes of plants and animals often contain large non-recombining regions due to a stepwise cessation of recombination generating “evolutionary strata” of genetic differentiation. The reasons for the extension of recombination suppression beyond sex-determining genes remain unclear. Sexual antagonism, involving the linkage to sex-determining genes of alleles beneficial in only one sex, is the prevailing hypothesis, as this explanation is both theoretically plausible and attractive. H",{"id":199,"funder":7,"programme":8,"title":200,"piName":10,"institution":62,"country":46,"year":13,"amount":201,"abstract":202},"cordis-european-research-council-award-832219","Anderson Localization of Light by Cold Atoms","€2,490,717","I propose to use large clouds of cold Ytterbium atoms to observe Anderson localization of light in three dimensions, which has challenged theoreticians and experimentalists for many decades. After the prediction by Anderson of a disorder-induced conductor to insulator transition for electrons, light has been proposed as ideal non interacting waves to explore coherent transport properties in the absence of interactions. The development in experiments and theory over the past several years have sh",{"id":204,"funder":7,"programme":8,"title":205,"piName":10,"institution":62,"country":46,"year":13,"amount":206,"abstract":207},"cordis-european-research-council-award-834177","Robots Explore plankton-driven Fluxes in the marine twIlight zoNE","€3,500,000","The scientific objective of REFINE is to understand and quantify the physical, biological and biogeochemical processes controlling the biological carbon pump, a key component of the oceanic CO2 sequestration. The oceanic twilight zone (TZ), which is located between the depths of 100 and 1000 m and represents 20% of the ocean's volume, is where these processes occur. Yet the TZ is not properly sampled during most ship-based oceanographic cruises and, because of its depths, it escapes satellite re",{"id":209,"funder":7,"programme":8,"title":210,"piName":10,"institution":211,"country":20,"year":13,"amount":10,"abstract":212},"cordis-european-research-council-award-832813","Spatio-temporal mechanisms of generative perception","UNIVERSITA DEGLI STUDI DI FIRENZE","How do we rapidly and effortlessly compute a vivid veridical representation of the external world from the noisy and ambiguous input supplied by our sensors? One possibility is that the brain does not process all incoming sensory information anew, but actively generates a model of the world from past experience, and uses current sensory data to update that model. This classic idea has been well formulised within the modern framework of Generative Bayesian Inference. However, despite these recent",{"id":214,"funder":7,"programme":8,"title":215,"piName":10,"institution":211,"country":20,"year":13,"amount":216,"abstract":217},"cordis-european-research-council-award-835286","Schwann Cell Options for chronic Pain Eradication","€2,185,921","Chronic pain, characterized by increased sensitivity to innocuous\u002Fmild stimuli (allodynia), afflicts 25% of the European adult population. Efficacy and\u002For safety of analgesic medicines is limited, and the treatment of chronic pain associated with inflammation, peripheral and central neuropathies and cancer remains unsatisfactory. Thus, identification of novel targets for better and safer analgesics is a major medical need. Transient receptor potential ankyrin 1 (TRPA1) channel, expressed by a su",{"id":219,"funder":7,"programme":8,"title":220,"piName":10,"institution":211,"country":20,"year":13,"amount":221,"abstract":222},"cordis-european-research-council-award-786379","European Ars Nova: Multilingual Poetry and Polyphonic Song in the Late Middle Ages","€2,193,375","Dante Alighieri at the dawn of the 1300s, as well as Eustache Deschamps almost a century later, conceived poetry as music in itself. But what happens with poetry when it is involved in the complex architecture of polyphony? The aim of this project is to study for the first time the corpus of 14th- and early 15th-century poetry set to music by Ars Nova polyphonists (more than 1200 texts). This repertoire gathers different poetic and musical traditions, as shown by the multilingual anthologies cop",{"id":224,"funder":7,"programme":8,"title":225,"piName":10,"institution":226,"country":227,"year":13,"amount":228,"abstract":229},"cordis-european-research-council-award-834370","Metabolic crosstalk in the regulation of inflammation","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","IE","€2,484,858","The study of the molecular basis to the immune response has for decades concerned receptors and the signalling pathways they activate which lead to immune cell activation.  Recently metabolic changes have also been shown to couple to immune effector responses. A shift in appreciation of the role of metabolites beyond energy metabolism and biosynthetic processes has emerged.  We have been examining the role of three metabolites in macrophages. We have evidence that two of these, malonyl-CoA and 2",{"id":231,"funder":7,"programme":8,"title":232,"piName":10,"institution":233,"country":46,"year":13,"amount":234,"abstract":235},"cordis-european-research-council-award-832606","Photochromic Solar Cells: Towards Photovoltaic Devices with Variable and Self-Adaptable Optical Transmission","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","€2,497,742","Solar Solar energy is an unlimited renewable source of energy but its contribution to European energy production is still minor. It is therefore urgent to develop innovative photovoltaic (PV) technologies and products, and to implement them massively. Among emerging photovoltaics, Dye-Sensitized Solar Cells (DSSCs) are competitive in terms of efficiency, cost, and more importantly stability. They can be made semi-transparent which is an appealing feature for building or automobile integrated pho",{"id":237,"funder":7,"programme":8,"title":238,"piName":10,"institution":233,"country":46,"year":13,"amount":239,"abstract":240},"cordis-european-research-council-award-835161","Conformational studies of highly dynamic viral replication complexes","€2,499,150","Paramyxoviruses, including, measles and a number of dangerous human pathogens, are negative strand RNA viruses that express their own machinery for transcription and replication. Different interactions between the nucleoprotein (N) and the phosphoprotein (P) are essential for chaperoning and assembly of N on newly synthesized RNA genomes to form nucleocapsids (NCs), as well as for initiating replication and transcription. Both N and tetrameric P exhibit extensive conformational disorder, with ve",{"id":242,"funder":7,"programme":8,"title":243,"piName":10,"institution":233,"country":46,"year":13,"amount":244,"abstract":245},"cordis-european-research-council-award-787320","The Quantum Structure of Black Holes and the Recovery of Information","€2,462,659","The detection of black-hole mergers in 2015 was a spectacular confirmation of General Relativity (GR). Yet, it is also in black holes that the fundamental conflict between GR and quantum mechanics (QM) is most acute.  Black holes are known to have a vast entropy.  Consistency with QM requires that the microstates giving rise to this entropy must be accessible at the horizon scale. However, GR coupled to field theory is incapable of supporting this horizon-scale microstructure!  My work has shown",{"id":247,"funder":7,"programme":8,"title":248,"piName":10,"institution":249,"country":168,"year":13,"amount":250,"abstract":251},"cordis-european-research-council-award-833214","Bio-Inspired Microfluidics Platform for Biomechanical Analysis","TECHNISCHE UNIVERSITEIT EINDHOVEN","€3,083,625","Biomechanical interactions between cells and their environment are essential in almost any biological process, from embryonic development to organ function to diseases. Hence, biomechanical interactions are crucial for health and disease. Examples are hydrodynamic interactions through fluid flow, and forces acting directly on cells. Existing methods to analyze and understand these interactions are limited however, since they do not offer the required combination of precisely controlled flow and ",{"id":253,"funder":7,"programme":8,"title":254,"piName":10,"institution":255,"country":46,"year":13,"amount":256,"abstract":257},"cordis-european-research-council-award-788240","A Comparative Study of Voice Perception in Primates","UNIVERSITE D'AIX MARSEILLE","€2,900,000","With COVOPRIM I propose to reconstruct the recent evolutionary history of one often overlooked component of speech and language: voice perception. Perceptual and neural mechanisms of voice perception will be compared between humans, macaques and marmosets –two highly vocal and extensively studied monkey species–to quantify cross-species differences and infer mechanisms potentially inherited from a common ancestor. Two key building blocks of vocal communication detailed in my past research in hum",{"id":259,"funder":7,"programme":8,"title":260,"piName":10,"institution":261,"country":262,"year":13,"amount":263,"abstract":264},"cordis-european-research-council-award-833251","Solar prominences: unraveling the ultimate condensation catastrophe","KATHOLIEKE UNIVERSITEIT LEUVEN","BE","€2,331,250","The most spectacular solar eruptions recorded in history - such as the Grand Daddy Prominence eruption on the 4th of June 1946 - invariably involve the violent ejection of a prominence: a giant, cool and dense plasma cloud that formed spontaneously within the million-degree solar corona. The role of the dominant prominence mass in all magnetically mediated coronal mass ejections is poorly understood, and yet a typical prominence easily outweighs our Earth population in mass (and the Earth itself",{"id":266,"funder":7,"programme":8,"title":267,"piName":10,"institution":268,"country":168,"year":13,"amount":21,"abstract":269},"cordis-european-research-council-award-833240","Probing stresses at the nanoscale","UNIVERSITEIT VAN AMSTERDAM","Summary:I will exploit novel molecules whose fluorescence properties depend strongly on the environment, notably on their spatial confinement, to study local stresses in complex materials down to the nanometer length scale and with unprecedented temporal resolution. Based on successful preliminary tests, I will develop this innovative methodology to tackle the fundamental scientific challenge of quantifying the long-range and very non-linear elasto-plastic stresses that govern the dynamics of fr",{"id":271,"funder":7,"programme":8,"title":272,"piName":10,"institution":273,"country":27,"year":13,"amount":274,"abstract":275},"cordis-european-research-council-award-835073","Development and Application of New NMR Methods for Studying Interphases and Interfaces in Batteries","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€3,498,219","The development of longer lasting, higher energy density and cheaper rechargeable batteries represents one of the major technological challenges of our society, batteries representing the limiting components in the shift from gasoline-powered to electric vehicles. They are also required to enable the use of more (typically intermittent) renewable energy, to balance demand with generation. This proposal seeks to develop and apply new NMR metrologies to determine the structure and dynamics of the ",{"id":277,"funder":7,"programme":8,"title":278,"piName":10,"institution":279,"country":280,"year":13,"amount":281,"abstract":282},"cordis-european-research-council-award-833423","Homogenous dynamics, arithmetic and equidistribution","THE HEBREW UNIVERSITY OF JERUSALEM","IL","€2,090,625","We consider the dynamics of actions on homogeneous spaces of algebraic groups,and propose to tackle a wide range of problems in the area, including the central open problems. One main focus in our proposal is the study of the intriguing and somewhat subtle rigidity properties of higher rank diagonal actions. We plan to develop new tools to study invariant measures for such actions, including the zero entropy case, and in particular Furstenberg's Conjecture about $\\times 2,\\times 3$-invariant mea",{"id":284,"funder":7,"programme":8,"title":285,"piName":10,"institution":286,"country":168,"year":13,"amount":287,"abstract":288},"cordis-european-research-council-award-834389","A new approach to design wireless receivers","UNIVERSITEIT TWENTE","€2,475,665","While most analog functions have been taken over by their digital counterparts, radio receivers today are complex analog electronic circuits. They include amplifier circuits to provide amplification of the weak antenna signals. Ideally the amplifiers provide linear gain, but unfortunately the amplifiers exploiting transistors are inherently nonlinear, causing fundamental problems if large unwanted signals are received simultaneously with weak desired signals. This is why a radio receiver is a co",{"id":290,"funder":7,"programme":8,"title":291,"piName":10,"institution":292,"country":108,"year":13,"amount":293,"abstract":294},"cordis-european-research-council-award-834534","Neutrophil - Chlamydia interactions at the crossroad of adaptation and defence","JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG","€2,499,340","Incidences of sexually transmitted diseases (STI) have increased during the past decades with a concomitant rapid spread of antibiotic resistant bacteria. Chlamydia trachomatis is the most frequent cause of bacterial STIs. These infections often remain asymptomatic and are consequently not diagnosed and treated, resulting in the subsequent development of severe chronic pathologies and an enormous economic burden for health systems. The reason for the asymptomatic nature of chlamydial infection i",{"id":296,"funder":7,"programme":8,"title":297,"piName":10,"institution":298,"country":262,"year":13,"amount":299,"abstract":300},"cordis-european-research-council-award-787307","Cracking the Anterior Cingulate Code: Toward a Unified Theory of ACC Function","UNIVERSITEIT GENT","€2,380,000","Anterior cingulate cortex is one of the largest riddles in cognitive neuroscience and presents a major challenge to mental health research. ACC dysfunction contributes to a wide spectrum of psychiatric and neurological disorders but no one knows what it actually does. Although more than a thousand papers are published about it each year, attempts to identify its function have been confounded by the fact that a multiplicity of tasks and events activate ACC, as if it were involved in everything.Re",{"id":302,"funder":7,"programme":8,"title":303,"piName":10,"institution":304,"country":305,"year":13,"amount":306,"abstract":307},"cordis-european-research-council-award-833915","Lane-free Artificial-Fluid Environment for Vehicular Traffic","POLYTECHNEIO KRITIS","EL","€2,495,500","Traffic congestion is a serious threat for the economic and social life of modern societies as well as for the environment, which calls for drastic and radical solutions. The proposal puts forward an utterly original idea that leads to a novel paradigm for vehicular traffic in the era of connected and automated vehicles (CAVs) and is based on two combined principles.The first principle is lane-free traffic, which renders the driving task for CAVs smoother and safer, as risky lane-changing manoeu",{"id":309,"funder":7,"programme":8,"title":310,"piName":10,"institution":311,"country":312,"year":13,"amount":313,"abstract":314},"cordis-european-research-council-award-834531","Soft-bodied Miniature Mobile Robots","KOC UNIVERSITY","TR","€2,499,750","Untethered mobile milli\u002Fmicrorobots would have a radical impact in medicine. Such untethered tiny machines could access smaller regions inside the body, remain inside the body for long durations as semi-implantable medical devices, and enable diagnostic and therapeutic medical operations in hard or currently not possible to reach regions inside the body with minimal or no invasion. While many groups have been working intensely on creating such new machines for potential medical applications, the",{"id":316,"funder":7,"programme":8,"title":317,"piName":10,"institution":318,"country":319,"year":13,"amount":320,"abstract":321},"cordis-european-research-council-award-789017","Correlated Molecular Quantum Gases in Optical Lattices","UNIVERSITAET INNSBRUCK","AT","€2,356,117","In a quantum engineering approach we aim to create strongly correlated molecular quantum gases for polar molecules confined in an optical lattice to two-dimensional geometry with full quantum control of all de-grees of freedom with single molecule control and detection. The goal is to synthesize a high-fidelity molec-ular quantum simulator with thousands of particles and to carry out experiments on phases and dynamics of strongly-correlated quantum matter in view of strong long-range dipolar int",{"id":323,"funder":7,"programme":8,"title":324,"piName":10,"institution":325,"country":262,"year":13,"amount":326,"abstract":327},"cordis-european-research-council-award-835243","Unexpected connections between a phagocytic machinery and mammalian fertilization","VIB VZW","€2,499,375","Fertilization is essential for a species to survive. Mammalian sexual reproduction requires the fusion between the haploid gametes sperm and egg to create a new diploid organism.  Although fertilization has been studied for decades, and despite the remarkable recent discoveries of Izumo (on sperm) and Juno (on oocytes) as a critical ligand:receptor pair, due to the structure of Izumo and Juno, it is clear that other players on both the sperm and the oocytes must be involved. While the focus of o",{"id":329,"funder":7,"programme":8,"title":330,"piName":10,"institution":331,"country":108,"year":13,"amount":332,"abstract":333},"cordis-european-research-council-award-789121","How MHC-I editing complexes shape the hierarchical immune response","JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN","€2,181,250","Our body constantly encounters pathogens or malignant transformation. Consequently, the adaptive immune system is in place to eliminate infected or cancerous cells. Specific immune reactions are triggered by selected peptide epitopes presented on major histocompatibility complex class I (MHC-I) molecules, which are scanned by cytotoxic T lymphocytes.Intracellular transport, loading, and editing of antigenic peptides onto MHC-I are coordinated by a highly dynamic multisubunit peptide-loading comp",{"id":335,"funder":7,"programme":8,"title":336,"piName":10,"institution":337,"country":338,"year":13,"amount":339,"abstract":340},"cordis-european-research-council-award-834742","Atomically-engineered nonlinear photonics with two-dimensional layered material superlattices","AALTO KORKEAKOULUSAATIO SR","FI","€2,442,448","The project aims at introducing a paradigm shift in the development of nonlinear photonics with atomically-engineered two-dimensional (2D) van der Waals superlattices (2DSs). Monolayer 2D materials have large optical nonlinear susceptibilities, a few orders of magnitude larger than typical traditional bulk materials. However, nonlinear frequency conversion efficiency of monolayer 2D materials is typically weak mainly due to their extremely short interaction length (~atomic scale) and relatively ",{"id":342,"funder":7,"programme":8,"title":343,"piName":10,"institution":344,"country":75,"year":13,"amount":345,"abstract":346},"cordis-european-research-council-award-834431","Hetero-structures for Efficient Luminescent Devices","UNIVERSITAT DE VALENCIA","€2,499,175","We propose to engineer stable-highly luminescent heterostructures based on defect tolerant benign perovskites and their integration into efficient planar\u002Fthin film optoelectronic devices. Primary targeted devices are: blue and white planar electroluminescent devices, high efficiency solar cells and electrically pumped lasers.We will use processing methods that are compatible with large area industrial processes, in particular focusing on vapour deposition using thermal sublimation of the perovsk",{"id":348,"funder":7,"programme":8,"title":349,"piName":10,"institution":350,"country":27,"year":13,"amount":351,"abstract":352},"cordis-european-research-council-award-832703","Laser control over crystal nucleation","UNIVERSITY OF GLASGOW","€2,488,162","The CONTROL programme I propose here is a five-year programme of frontier research to develop a novel platform for the manipulation of phase transitions, crystal nucleation, and polymorph control based on a novel optical-tweezing technique and plasmonics. About 20 years ago, it was shown that lasers can nucleate crystals in super-saturated solution and might even be able to select the polymorph that crystallises. However, no theoretical model was found explaining the results and little progress ",{"id":354,"funder":7,"programme":8,"title":355,"piName":10,"institution":356,"country":168,"year":13,"amount":357,"abstract":358},"cordis-european-research-council-award-788572","Remembering Activism: The Cultural Memory of Protest in Europe","UNIVERSITEIT UTRECHT","€2,498,750","Mass demonstrations are newsworthy. But how are they remembered when they are no longer news? Social movements are usually studied in terms of their emergence and subsidence. Despite recognition that activists are ‘inspired’ by precedents, the afterlife of activism in story and image has never been systematically explored. ReAct contends that knowledge about this cultural memory is needed for a full understanding civil resistance.ReAct will provide the first in-depth account of the remembering a",{"id":360,"funder":7,"programme":8,"title":361,"piName":10,"institution":362,"country":363,"year":13,"amount":364,"abstract":365},"cordis-european-research-council-award-787097","Mid-infrared optical dual-comb generation and spectroscopy with one unstabilized semiconductor laser","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","CH","€3,210,000","ONE-MIX proposes to develop single-source dual-comb lasers for mid-infrared (2-5 μm wavelength)spectroscopy, potentially enabling many new applications in science and industry, such as environment, safety,pharma, and health. This proposal extends our recent demonstration of a dual-comb MIXSEL (ModelockedIntegrated eXternal-cavity Surface Emitting Lasers) in the near-infrared, validated by measuring weak waterabsorption at 968 nm. Many more relevant gas absorption lines, however, are in the mid-i",{"id":367,"funder":7,"programme":8,"title":368,"piName":10,"institution":369,"country":108,"year":13,"amount":21,"abstract":370},"cordis-european-research-council-award-834050","Cross-Linguistic statistical inference using hierarchical Bayesian models","EBERHARD KARLS UNIVERSITAET TUEBINGEN","Historical linguistics and linguistic typology share the objective of explaining cross-linguistic variation. Their traditional research agendas have been largely disjoint though since historical linguistics strives for depth and typology for breadth. This tension has been replicated in current statistical and computational renderings of two sub-disciplines. Computational models of language change generally focus on individual language families, while statistical typology pays little attention to",{"id":372,"funder":7,"programme":8,"title":373,"piName":10,"institution":26,"country":27,"year":13,"amount":374,"abstract":375},"cordis-european-research-council-award-833861","The Migration Challenge: Labour Markets, Policy Reforms, and Social Cohesion","€2,099,223","International migration is among the most important issues that have shaped the policy debates and political landscape in Europe in recent decades. Both the intra-European migration of workers and the influx of refugee migrants from outside Europe pose enormous economic and political challenges to Europe in the coming decades. This proposed research will investigate three key areas in which migration can have fundamental consequences for both economies and societies: (i) The Impact of Migration ",{"id":377,"funder":7,"programme":8,"title":378,"piName":10,"institution":379,"country":108,"year":13,"amount":380,"abstract":381},"cordis-european-research-council-award-787331","Uncovering the Origins of Mass: Discovery of the di-Higgs Process and Constraints on the Higgs Self-Coupling","HUMBOLDT-UNIVERSITAET ZU BERLIN","€2,262,897","The Standard Model of particle physics describes the elementary constituents of matter and their interactions. In 2012, its last ingredient, the Higgs boson, was discovered at the Large Hadron Collider (LHC). The exploration of the Higgs boson is now one of the most exciting avenues to explore for New Physics beyond the Standard Model and allows some of the most pressing problems in theoretical physics to be addressed, such as the origins of the electroweak symmetry breaking mechanism. This impo",{"id":383,"funder":7,"programme":8,"title":384,"piName":10,"institution":385,"country":386,"year":13,"amount":21,"abstract":387},"cordis-european-research-council-award-789030","Structural mechanism coupling the reduction of oxygen to proton pumping in living cells","GOETEBORGS UNIVERSITET","SE","Every breath you take delivers oxygen to mitochondria within the cells of your body. Mitochondria are energy transducing organelles that accept electrons liberated from the food that you eat in order to generate a transmembrane proton concentration gradient. Cytochrome c oxidase is an integral membrane protein complex in the mitochondria that accepts four electrons and reduces molecular oxygen to two water molecules while simultaneously pumping protons against a transmembrane potential. Cytochro",{"id":389,"funder":7,"programme":8,"title":390,"piName":10,"institution":391,"country":168,"year":13,"amount":392,"abstract":393},"cordis-european-research-council-award-835263","Speech Prosody in Interaction: The form and function of intonation in human communication","STICHTING RADBOUD UNIVERSITEIT","€2,481,196","Intonation, the modulation of voice pitch, is essential for communication as it conveys information that helps listeners make inferences about the pragmatic intent of the speaker. Despite increased understanding of intonations importance, there is little agreement even about essential aspects of its structure and meaning. This is in large part because research has focused either on the form of intonation, often taking a reductive approach to meaning, or has concentrated on meaning but without fu",{"id":395,"funder":7,"programme":8,"title":396,"piName":10,"institution":397,"country":280,"year":13,"amount":398,"abstract":399},"cordis-european-research-council-award-835227","Brain metastases: Deciphering tumor-stroma interactions in three dimensions for the rational design of nanomedicines","TEL AVIV UNIVERSITY","€2,353,125","Brain metastases represent a major therapeutic challenge. Despite significant breakthroughs in targeted therapies, survival rates of patients with brain metastases remain poor. Nowadays, discovery, development and evaluation of new therapies are performed on human cancer cells grown in 2D on rigid plastic plates followed by in vivo testing in immunodeficient mice. These experimental settings are lacking and constitute a fundamental hurdle for the translation of preclinical discoveries into clini",{"id":401,"funder":7,"programme":8,"title":402,"piName":10,"institution":403,"country":319,"year":13,"amount":404,"abstract":405},"cordis-european-research-council-award-832874","Mapping out the poetic landscape(s) of the Roman empire: Ethnic and regional variations, socio-cultural diversity, and cross-cultural transformations","UNIVERSITAT WIEN","€2,000,529","Poetry was the most affordable art form in the Roman world: all it required were words, and someone with a talent to arrange them in a meaningful, aesthetically convincing way. Yet, the study of Latin poetry has traditionally almost exclusively focused on a small, judiciously transmitted canon of texts – a segment of Rome’s artistic production that favours the poetry that was produced, enjoyed, and controlled, by a political, social, and financial urban elite, reinforcing their claim to cultural",{"id":407,"funder":7,"programme":8,"title":408,"piName":10,"institution":409,"country":108,"year":13,"amount":410,"abstract":411},"cordis-european-research-council-award-832833","Quadratic refinements in algebraic geometry","UNIVERSITAET DUISBURG-ESSEN","€2,124,663","Enumerative geometry, the mathematics of counting numbers of solutions to geometric problems, and its modern descendents, Gromov-Witten theory, Donaldson-Thomas theory,   quantum cohomology and many other related fields,  analyze geometric problems by computing numerical invariants, such as intersection numbers or degrees of characteristic classes. This essentially algebraic approach has been successful mainly in the study of problems over the complex numbers and other algebraically closed field",{"id":413,"funder":7,"programme":8,"title":414,"piName":10,"institution":415,"country":27,"year":13,"amount":416,"abstract":417},"cordis-european-research-council-award-833802","Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry","UNIVERSITY OF WARWICK","€1,904,305","The objective of this research project is to develop new and original methods to address  a number of fundamental questions  in the development of smooth ergodic theory and dynamical systems.  Furthermore, this theory will have  important and diverse applications to many different areas of mathematics (in particular geometry, but also number theory and topology).The questions we are interested in are specifically related to the study of  resonances, which characterise statistical properties of d",{"id":419,"funder":7,"programme":8,"title":420,"piName":10,"institution":421,"country":280,"year":13,"amount":422,"abstract":423},"cordis-european-research-council-award-834735","Sensitivity, Stability, and Computation","REICHMAN UNIVERSITY","€1,754,500","Noise sensitivity and noise stability of Boolean functions, percolation, and other models were introduced in a paper by Benjamini,  Kalai, and Schramm (1999) and were extensively studied in the last two decades.  We propose to extend this study to various stochastic and combinatorial models, and to explore connections with computer science, quantum information, voting methods and other areas. The first goal of our proposed project is to push the mathematical theory of noise stability and noise s",{"id":425,"funder":7,"programme":8,"title":426,"piName":10,"institution":427,"country":168,"year":13,"amount":10,"abstract":428},"cordis-european-research-council-award-834279","The Quest of the Argonautes - from Myth to Reality","WAGENINGEN UNIVERSITY","Argonaute nucleases are key players of the eukaryotic RNA interference (RNAi) system. Using small RNA guides, these Argonaute (Ago) proteins specifically target complementary RNA molecules, resulting in regulation of a wide range of crucial processes, including chromosome organization, gene expression and anti-virus defence. Since 2010, my research team has studied closely-related prokaryotic Argonaute (pAgo) variants. This has revealed spectacular mechanistic variations: several thermophilic pA",{"id":430,"funder":7,"programme":8,"title":431,"piName":10,"institution":432,"country":27,"year":13,"amount":21,"abstract":433},"cordis-european-research-council-award-835297","Predicting Routes Of Tumour Evolution driven by Unstable genomes and Selection","THE FRANCIS CRICK INSTITUTE LIMITED","Despite progress in cancer drug development, the majority of patients who present with advanced, metastatic, solid tumours have incurable disease due to underlying cancer genomic diversity that provides a substrate for evolution and selection of drug resistance. The aim of this proposal is to describe, synthesise and model the micro- and macroevolutionary patterns of genomic instability underpinning the evolutionary dynamics of tumour life histories, to improve patient stratification, treatment ",{"id":435,"funder":7,"programme":8,"title":436,"piName":10,"institution":286,"country":168,"year":13,"amount":437,"abstract":438},"cordis-european-research-council-award-834709","Monitoring Biodiversity from Space","€2,470,315","Life, with all its diversity, is in crisis. As humans increasingly encroach on biologically complex semi- natural landscapes, no organism, place or ecological function remains unaffected. While all 196 parties (195 countries plus the European Union) to the UN Convention on Biodiversity (CBD) have agreed to monitor the state of biodiversity, the currently available methods to do so leave much to be desired. Traditional monitoring involves the field observation of species by trained specialists, a",{"id":440,"funder":7,"programme":8,"title":441,"piName":10,"institution":33,"country":27,"year":13,"amount":442,"abstract":443},"cordis-european-research-council-award-834115","From FUnction-based TO MOdel-based automated probabilistic reasoning for DEep Learning","€2,417,890","Machine learning is revolutionising computer science and AI. Much of its success is due to deep neural networks, which have demonstrated outstanding performance in perception tasks such as image classification. Solutions based on deep learning are now being deployed in real-world systems, from virtual personal assistants to self-driving cars. Unfortunately, the black-box nature and instability of deep neural networks is raising concerns about the readiness of this technology. Efforts to address ",{"id":445,"funder":7,"programme":8,"title":446,"piName":10,"institution":33,"country":27,"year":13,"amount":447,"abstract":448},"cordis-european-research-council-award-834253","Trade Agreements and Supply Chains","€1,817,096","Recent decades have witnessed two major trends in international trade. The first is the increasing fragmentation of production processes across countries: advances in information and communication technology and falling trade barriers have allowed firms to retain in their domestic economies only a subset of production stages, leading to a surge of trade in intermediate goods. The second trend is the proliferation of regional trade agreements (RTAs), which have risen in number and have become “de",{"id":450,"funder":7,"programme":8,"title":451,"piName":10,"institution":452,"country":46,"year":13,"amount":453,"abstract":454},"cordis-european-research-council-award-834175","General theory for Big Bayes","UNIVERSITE PARIS DAUPHINE","€2,176,702","In the modern era of complex and large data sets, there is stringent need for flexible, sound and scalable inferential methods to analyse them. Bayesian approaches have been increasingly used in statistics and machine learning and in all sorts of applications such as biostatistics, astrophysics, social science etc. Major advantages of Bayesian approaches are: their ability to model complex models in a hierarchical way, their coherency and ability to deliver not only point estimators but also mea",{"id":456,"funder":7,"programme":8,"title":457,"piName":10,"institution":33,"country":27,"year":13,"amount":458,"abstract":459},"cordis-european-research-council-award-832467","The Homeostatic Regulation and Biological Function of Sleep","€2,374,999","Sleep is vital and universal, but its biological function remains unknown. This project will seek to understand why we need to sleep by studying how the brain responds to sleep loss. My previous work in Drosophila showed that rising sleep pressure activates two dozen sleep-inducing neurons in the dorsal fan-shaped body (dFB) of the central complex. Sleep need is encoded in the electrical excitability of these neurons, which fluctuates because two potassium conductances, voltage-gated Shaker and ",{"id":461,"funder":7,"programme":8,"title":462,"piName":10,"institution":33,"country":27,"year":13,"amount":463,"abstract":464},"cordis-european-research-council-award-833792","Remotely-controlled functional synthetic tissues","€2,428,065","We will make synthetic tissues for applications in medicine. In the short-term, synthetic tissues will be used to deliver therapeutics; ultimately, synthetic tissues will be used as components of surgical implants. The synthetic tissues will be formed from patterned 3D-printed picoliter droplet networks. They will be functionally active and subject to external control. They will be safe, because they cannot replicate.  Key aspects of synthetic tissues, which were introduced by our laboratory, re",{"id":466,"funder":7,"programme":8,"title":467,"piName":10,"institution":33,"country":27,"year":13,"amount":468,"abstract":469},"cordis-european-research-council-award-832994","Hydrogen Bonding Phase Transfer Catalysis","€2,499,070","The objective of the research described in this proposal is to develop a new mode of activation for catalysis leading to more sustainable catalytic processes using abundant feedstock materials.  By merging hydrogen bonding and phase transfer catalysis, we propose that hydrogen bonding of an insoluble unreactive anionic nucleophile with a hydrogen bond donor catalyst will form a soluble and reactive entity now capable of carbon-nucleophile bond formation with concomitant release of the hydrogen b",{"id":471,"funder":7,"programme":8,"title":472,"piName":10,"institution":74,"country":75,"year":13,"amount":473,"abstract":474},"cordis-european-research-council-award-832980","Biogeographic and cultural adaptations of early humans during the first intercontinental dispersals","€2,499,996","Our understanding of the emergence and dispersal of the earliest tool-making hominins has been revolutionised in the last decade, with sites in eastern Africa and China pushing both events more than half a million years earlier than previously thought. Traditional models linking biological speciation, cultural innovation and migration events with climatic pulses have remained theoretical, and recent discoveries suggest that the picture of the earliest human colonization across the Old World is f",{"id":476,"funder":7,"programme":8,"title":477,"piName":10,"institution":478,"country":338,"year":13,"amount":479,"abstract":480},"cordis-european-research-council-award-834728","Quasiconformal Methods in Analysis and Applications","HELSINGIN YLIOPISTO","€2,280,350","The use of delicate  quasiconformal  methods, in conjunction with  convex integration and\u002For nonlinear Fourier analysis, will be the common theme of the proposal. A number of important outstanding problems are susceptible to attack via these methods. First and foremost, Morrey's fundamental question in two dimensional vectorial calculus of variations will be considered as well as the related conjecture of Iwaniec regarding the sharp $L^p$ bounds for the Beurling transform. Understanding the geom",{"id":482,"funder":7,"programme":8,"title":483,"piName":10,"institution":427,"country":168,"year":13,"amount":484,"abstract":485},"cordis-european-research-council-award-834775","Biodiversity and recovery of forest in tropical landscapes","€2,499,895","The challenge- Tropical forests are global hotspots of biodiversity, play key roles in the global carbon and water cycle and deliver crucial ecosystem services but are threatened by human-induced climate change, deforestation and biodiversity loss. I focus on forests that regrow after complete forest removal for agriculture (secondary forests), because they cover large areas, have great potential to recover biodiversity and carbon, and are the basis for ecosystem restoration. The key challenge i",{"id":487,"funder":7,"programme":8,"title":488,"piName":10,"institution":489,"country":46,"year":13,"amount":490,"abstract":491},"cordis-european-research-council-award-835294","Privacy and Utility Allied","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","€2,223,779","With the ever-increasing use of internet-connected devices, such as computers, smart grids, IoT appliances and GPS-enabled equipments,   personal data are collected in larger and larger amounts, and then stored and manipulated  for the most diverse purposes.  Undeniably, the big-data technology   provides enormous benefits to industry, individuals and society, ranging from improving business strategies and boosting  quality of  service to enhancing  scientific progress. On the other hand, howeve",{"id":493,"funder":7,"programme":8,"title":494,"piName":10,"institution":489,"country":46,"year":13,"amount":495,"abstract":496},"cordis-european-research-council-award-788851","Network Motion","€2,498,529","NEMO, NEtwork MOtion, is an inter-disciplinary proposal centered on network dynamics. The inter-disciplinarity spans from communication engineering to mathematics, with an innovative interplay between the two.NEMO’s focus is on stochastic geometry. This emerges as one of the most important new conceptual  and operational tools of the last 10 years in wireless networking, with a major academic and industrial impact on architecture, protocol design, planning and economic analysis.Nevertheless, the",{"id":498,"funder":7,"programme":8,"title":499,"piName":10,"institution":500,"country":108,"year":13,"amount":501,"abstract":502},"cordis-european-research-council-award-788296","Holographic acoustic assembly and manipulation","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€2,420,125","Acoustic waves exert forces when they interact with matter. Sound, and in particular ultrasound, which has a wavelength of a few hundred microns in water, is a benign and versatile tool, that has been successfully used to manipulate, trap and levitate microparticles and cells. The acoustic contrast between the material and the medium, and the spatial variation of the ultrasound field determine the interaction. Resonators and arrays of a few hundred transducers have thus far been used to generate",{"id":504,"funder":7,"programme":8,"title":505,"piName":10,"institution":506,"country":108,"year":13,"amount":507,"abstract":508},"cordis-european-research-council-award-835268","Medical microbots to support new assisted reproduction techniques","TECHNISCHE UNIVERSITAET CHEMNITZ","€2,496,141","Infertility is a health issue with sociological and psychological implications that affects approximately 50 million couples worldwide and therefore receives global attention. Among fertility issues, male infertility is diagnosed in about 40% of all cases and the major causes are poor motility of spermatozoa (asthenospermia), low sperm count (oligospermia), abnormal sperm morphology (teratospermia) and\u002For combinations of these, leading to their inability to fertilize an oocyte. Such problems hav",{"id":510,"funder":7,"programme":8,"title":511,"piName":10,"institution":512,"country":12,"year":13,"amount":21,"abstract":513},"cordis-european-research-council-award-834410","Fano Photonics","DANMARKS TEKNISKE UNIVERSITET","A new class of devices exploiting Fano resonances and with important applications in information technology is suggested. Typically, the resonance of a system is described by a frequency and a lifetime, leading to a Lorentzian lineshape function. If the system instead involves interference between a discrete resonance and a continuum, a Fano lineshape appears with fundamentally different characteristics. Here, the Fano resonance is used to make a novel integrated mirror, enabling realization of ",{"id":515,"funder":7,"programme":8,"title":516,"piName":10,"institution":517,"country":363,"year":13,"amount":518,"abstract":519},"cordis-european-research-council-award-834782","Correlations in Large Quantum Systems","UNIVERSITAT ZURICH","€1,876,050","This project is devoted to the mathematical analysis of important physical properties of many-body quantum systems. We will be interested in properties of the ground state and low-energy excitations but also of non-equilibrium dynamics. We are going to consider systems with different statistics and in different regimes. The questions we are going to address have a common aspect: correlations among particles play a crucial role. Our main goal consists in developing new tools that allow us to corr",{"id":521,"funder":7,"programme":8,"title":522,"piName":10,"institution":273,"country":27,"year":13,"amount":523,"abstract":524},"cordis-european-research-council-award-834203","From the accretion disk to the cluster halo: the multi-scale physics of black hole feedback","€2,489,918","It is firmly established that supermassive black holes (SMBHs) have a profound influence on the evolution of galaxies and galaxy groups\u002Fclusters. Yet, almost 20 years after this realization, fundamental questions remain. What determines the efficiency with which an active galactic nucleus (AGN) couples to its surroundings? Why does AGN feedback appear to be ineffective in low-mass galaxies? In maintenance-mode feedback, how does the AGN regulate to closely balance cooling? How does the nature of",{"id":526,"funder":7,"programme":8,"title":527,"piName":10,"institution":528,"country":108,"year":13,"amount":313,"abstract":529},"cordis-european-research-council-award-786020","Atomic-scale Design of Majorana states and their Innovative Real-space Exploration","UNIVERSITY OF HAMBURG","Fault-tolerant topological quantum computation has become one of the most exciting research directions in modern condensed matter physics. As a key operation the braiding of non-Abelian anyons has been proposed theoretically. Such exotic quasiparticles can be realized as zero-energy Majorana bound states at the ends of  one-dimensional magnetic nanowires in proximity to s-wave superconductors in the presence of high spin-orbit coupling. In contrast to previous attempts to realize such systems ex",{"id":531,"funder":7,"programme":8,"title":532,"piName":10,"institution":533,"country":280,"year":13,"amount":21,"abstract":534},"cordis-european-research-council-award-831783","Delivery and On-Demand Activation of Chemically Synthesized and Uniquely Modified Proteins in Living Cells","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","While advanced molecular biology approaches provide insight on the role of proteins in cellular processes, their ability to freely modify proteins and control their functions when desired is limited, hindering the achievement of a detailed understanding of the cellular functions of numerous proteins. At the same time, chemical synthesis of proteins allows for unlimited protein design, enabling the preparation of unique protein analogues that are otherwise difficult or impossible to obtain. Howev",{"id":536,"funder":7,"programme":8,"title":537,"piName":10,"institution":538,"country":75,"year":13,"amount":10,"abstract":539},"cordis-european-research-council-award-834934","New geochemical approach to reconstruct tropical palaeo-atmospheric dynamics","UNIVERSITAT AUTONOMA DE BARCELONA","Tropical climates are changing rapidly in the most populated regions of the planet. The changes largely arise from alterations in the Hadley circulation driven by natural and anthropogenic factors, whose relative roles and temporal variability are unclear. These knowledge gaps are in part due to the shortage of methods to study the atmospheric circulation before the advent of instrumental and satellites observations, and compounded by the contradictions between models and palaeo-data.The aim of ",{"id":541,"funder":7,"programme":8,"title":542,"piName":10,"institution":543,"country":108,"year":13,"amount":10,"abstract":544},"cordis-european-research-council-award-834154","Tumor suppressor pathways counteracting oncogenic immune receptor signaling in T-Cell Lymphoma","KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)","T cell non-Hodgkin lymphomas (T-NHLs) are highly aggressive malignancies that are largely resistant to conventional therapies. T-NHLs remain significantly understudied, and their molecular pathogenesis is still not well defined. Comprehensive analysis of mature T-cell lymphomas has identified multiple gain-of-function mutations in T-cell receptor (TCR) signaling molecules as an overarching hallmark of T-NHL sub-entities. Under physiological conditions, these molecules control the expansion, surv",{"id":546,"funder":7,"programme":8,"title":547,"piName":10,"institution":500,"country":108,"year":13,"amount":548,"abstract":549},"cordis-european-research-council-award-834302","Towards identification of the unifying principles of vertebrate adaptive immunity","€2,498,813","About 500 million years ago, the two sister groups of vertebrates independently evolved alternative forms of adaptive immunity, representing a striking example of convergent evolution. Whereas the components and functions of the immune system in jawed vertebrates (ranging from sharks to humans) are well characterized, much remains to be learned about adaptive immunity in jawless vertebrates (lampreys and hagfishes). Up to now, progress in understanding immunity in jawless fishes was hampered by ",{"id":551,"funder":7,"programme":8,"title":552,"piName":10,"institution":553,"country":46,"year":13,"amount":554,"abstract":555},"cordis-european-research-council-award-833125","Breaking of highly energetic waves","ECOLE NORMALE SUPERIEURE PARIS-SACLAY","€2,499,946","HIGHWAVE is an interdisciplinary project at the frontiers of coastal\u002Focean engineering, earth system science, statistics and fluid mechanics that will explore fundamental open questions in wave breaking. Why do waves break, how do they dissipate energy and why is this important? A central element of the work builds on recent international developments in the field of wave breaking and wave run-up led by the PI that have provided the first universal criterion for predicting the onset of breaking ",{"id":557,"funder":7,"programme":8,"title":558,"piName":10,"institution":559,"country":27,"year":13,"amount":560,"abstract":561},"cordis-european-research-council-award-787258","Inclusive Public Space: Law, Universality and Difference in the Accessibility of Streets","UNIVERSITY OF LEEDS","€2,499,672","This project considers the accessibility of public space – focusing on pedestrian access to streets. It explores law’s engagement with the exclusion which occurs when streets are designed, operated or managed so as to deny access to pedestrians whose bodies, minds or life circumstances do not ‘fit’. Such exclusion is damaging both to individuals and communities.With a view to understanding how states and the EU can more effectively ensure that public space is inclusive, the project aims to deepe",{"id":563,"funder":7,"programme":8,"title":564,"piName":10,"institution":565,"country":75,"year":13,"amount":566,"abstract":567},"cordis-european-research-council-award-835105","Yoctosecond imaging of QCD collectivity using jet observables","UNIVERSIDAD DE SANTIAGO DE COMPOSTELA","€2,497,750","QCD is the only sector of the Standard Model where the exploration of the first levels of complexity, built from fundamental interactions at the quantum level, is experimentally feasible. An outstanding example is the thermalised state of QCD matter formed when heavy atomic nuclei are smashed in particle colliders. Systematic experimental studies, carried out in the last two decades, overwhelmingly support the picture of a deconfined state of matter, which behaves as a nearly perfect fluid, form",{"id":569,"funder":7,"programme":8,"title":570,"piName":10,"institution":571,"country":20,"year":13,"amount":572,"abstract":573},"cordis-european-research-council-award-835103","The role of damage-induced non coding RNA in the control of DNA damage response activation at telomeres in aging","IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS","€2,497,500","Genome instability is a hallmark of cellular and organismal aging. Cells evolved a prompt set of actions known as the DNA damage response (DDR) to preserve genome integrity. Until very recently, DDR pathways have been studied as networks of interacting proteins only. We discovered that the full activation of the DDR pathways depends also on long and short damage-induced non coding RNA synthesised from exposed DNA ends of DNA double-strand breaks (DSB). Inhibitory antisense oligonucleotides (ASO)",{"id":575,"funder":7,"programme":8,"title":576,"piName":10,"institution":255,"country":46,"year":13,"amount":10,"abstract":577},"cordis-european-research-council-award-832237","Computational Photochemistry in the Long Timescale: Sub-ns Photoprocesses in DNA","My goal in the SubNano project is to massively speed up the dynamics simulation of photoexcited molecules to allow addressing sub-nanosecond phenomena (that is, one thousand times above the current limits). The sub-ns methodology will be employed to investigate the long timescale nonadiabatic dynamics of photoinduced processes in nucleic acids, including DNA photostabilization via excitonic processes, biological fluorescent markers, and transient anion formation in DNA repair.To fulfill these go",{"id":579,"funder":7,"programme":8,"title":580,"piName":10,"institution":581,"country":27,"year":13,"amount":10,"abstract":582},"cordis-european-research-council-award-835279","High temperature superconductivity and the Catch-22 conundrum","UNIVERSITY OF BRISTOL","CATCH-22 sets out to resolve the mystery of the cuprate high temperature superconductors. Hailed as one of the major discoveries of the 20th Century, its central mysteries – the pairing mechanism, the origin of the ‘pseudogap’ and the nature of the ‘strange metal’ phase, have remained elusive for over 30 years. Typically, what scatters electrons also binds them into pairs, and in the cuprates, the strong pairing interaction manifests itself in the strange metal phase as intense scattering, so st",{"id":584,"funder":7,"programme":8,"title":585,"piName":10,"institution":385,"country":386,"year":13,"amount":21,"abstract":586},"cordis-european-research-council-award-835068","Topotronic multi-dimensional spin Hall nano-oscillator networks","TOPSPIN will focus on spin Hall nano-oscillators (SHNOs), which are nano-sized, ultra-tunable, and CMOS compatible spin wave based microwave oscillators. TOPSPIN will push the boundaries of SHNO lithography, frequency, speed, and power consumption by combining topological insulators, having record high spin Hall efficiencies, with materials having ultra-high spin wave frequencies. TOPSPIN will reduce the required current densities 1-2 orders of magnitude compared to state-of-the-art, making SHNO",{"id":588,"funder":7,"programme":8,"title":589,"piName":10,"institution":590,"country":20,"year":13,"amount":591,"abstract":592},"cordis-european-research-council-award-833834","The Water Cultures of Italy, 1500-1900","UNIVERSITA CA' FOSCARI  VENEZIA","€2,444,549","Behind this project lies a paradox: water, although vital for life, has historically had little intrinsic value. Considered base and common as a drink, it was nevertheless the most symbolically charged of the elements; of limited monetary value in and of itself, access to it was in fact hard-fought, the foundation and driving force of society. The Water Cultures project aims to create a new field of study, based around the social and cultural history of a people’s polyvalent interactions with wa",{"id":594,"funder":7,"programme":8,"title":595,"piName":10,"institution":596,"country":46,"year":13,"amount":10,"abstract":597},"cordis-european-research-council-award-833933","Historical Research and Data Processing on Ancient Vietnamese Inscriptions","ECOLE PRATIQUE DES HAUTES ETUDES","Driven by a general movement in Asia to invest in Classical studies, the project Vietnamica aims for a historical and linguistic study of ancient, invaluable Vietnamese inscriptions, while also helping to determine a ground-breaking method for the use of epigraphic resources. In partnership with Han-Nôm Institute and Vietnam National University, the project is motivated by the recent divulgence of 40,000 paper stampings that reproduce the inscriptions engraved on the surfaces of 25,000 steles er",{"id":599,"funder":7,"programme":8,"title":600,"piName":10,"institution":601,"country":27,"year":13,"amount":602,"abstract":603},"cordis-european-research-council-award-789116","ENIneering MAterial properties with advanced laser direct writing","UNIVERSITY OF SOUTHAMPTON","€2,499,957","Ultrafast laser material processing is approaching its limits in terms of ability to produce innovative materials withcompositional and structural consistency. The main idea of this project is to remove barriers to product development and gobeyond state-of-the-art by applying tailored and few-cycle laser pulses (FCLPs) for engineering of materials.In this project I will investigate the interaction between intense ultra-short light pulses and matter at or below the wavelengthscale reaching states",{"id":605,"funder":7,"programme":8,"title":606,"piName":10,"institution":607,"country":46,"year":13,"amount":608,"abstract":609},"cordis-european-research-council-award-788812","An Etymological Dictionary of the Japonic Languages","ECOLE DES HAUTES ETUDES EN SCIENCES SOCIALES","€2,470,200","It is a paradoxical situation that with Japan being the third modern economy and Japanese, the main Japonic language, being the 10th in the world in terms of native speakers and the most widely studied Asian language, the Japonic language family still lacks an etymological dictionary.The present research project will rectify this situation. The benefits of an etymological dictionary of Japonic are obvious: not only it will be of a great use to the specialists working on pre-modern Japan and Ryuk",{"id":611,"funder":7,"programme":8,"title":612,"piName":10,"institution":331,"country":108,"year":13,"amount":613,"abstract":614},"cordis-european-research-council-award-833714","Economic Consequences of Restrictions on the Usage of Cookies","€1,998,250","Cookies (or HTTP cookies) enable companies to collect and exchange extensive information about users. This information is often used to improve the performance of online advertising, which website publishers rely on in order to finance the free content to which their users have become accustomed. Yet, the collection of information leads to a loss of privacy. Accordingly, EU policy makers have put forward initiatives to restrict cookie usage (e.g., General Data Protection Regulation (GDPR), upcom",{"id":616,"funder":7,"programme":8,"title":617,"piName":10,"institution":618,"country":46,"year":13,"amount":21,"abstract":619},"cordis-european-research-council-award-834195","The Sound of Empire in 20th-c. Colonial Cultures: Rethinking History through Music","FONDATION UNIVERSITE COTE D'AZUR","To better understand cultural relations in today’s multi-ethnic, multicultural societies, we need to revisit the legacy of modern empires. This project delves into the musical dimension of the French empire and what differences were negotiated through aurality, long-neglected by historians. Focusing on musical life and media from Dakar and Rabat to Saigon, 1900-1962, it studies how music was practiced, heard, and understood in a variety of colonial contexts. Crucially important is the need to in",{"id":621,"funder":7,"programme":8,"title":622,"piName":10,"institution":533,"country":280,"year":13,"amount":623,"abstract":624},"cordis-european-research-council-award-833399","Proteome profiling using plasmonic nanopore sensors","€2,498,869","To date, antibody-free protein identification methods have not reached single-molecule precision. Instead, they rely on averaging from many cells, obscuring the details of important biological processes. The ability to identify each individual protein from within a single cell would transform proteomics research and biomedicine. However, single protein identification (ID) presents a major challenge, necessitating a breakthrough in single-molecule sensing technologies.We propose to develop a meth",{"id":626,"funder":7,"programme":8,"title":627,"piName":10,"institution":628,"country":363,"year":13,"amount":468,"abstract":629},"cordis-european-research-council-award-834068","Identifying how Evolution exploits physical properties of tissues to generate the complexity and diversity of Life","UNIVERSITE DE GENEVE","My project focuses on answering one fundamental question: what are the drivers of Life’s morphological complexity and diversity? I claim that this question can only be addressed by a Newtonian-Darwinian synthesis that considers how Evolution exploits the physical properties of living matter. I will investigate how the evolutionary process explores the phase space of possible interactions between physical (mechanics, reaction-diffusion) and biological (cell signalling, proliferation, migration) p",{"id":631,"funder":7,"programme":8,"title":632,"piName":10,"institution":633,"country":108,"year":13,"amount":634,"abstract":635},"cordis-european-research-council-award-787840","Complexity and Condition in Algebra and Numerics","TECHNISCHE UNIVERSITAT BERLIN","€2,297,163","This proposal connects three areas that are considered distant from each other: computational complexity, algebraic geometry, and numerics. In the last decade, it became clear that the fundamental questions of computational complexity (P vs NP) should be studied in algebraic settings, linking them to problems in algebraic geometry. Recent progress on this challenging and very difficult questions led to surprising progress in computational invariant theory, which we want to explore thoroughly. We",{"id":637,"funder":7,"programme":8,"title":638,"piName":10,"institution":639,"country":108,"year":13,"amount":640,"abstract":641},"cordis-european-research-council-award-833408","Catalytic cascade reactions. From fundamentals of nanozymes to applications based on gas-diffusion electrodes","RUHR-UNIVERSITAET BOCHUM","€2,499,462","Nanoparticles with etched substrate channels are proposed as a simplified enzyme mimic, nanozymes, for electrocatalysis providing concave catalytically active sites together with the local modulation of electrolyte composition. This concept will be extended to bimetallic core-shell structures with etched channels to provide locally confined catalyst surfaces with varying selectivity. The first catalytic reaction at the channel entrance selectively generates a product, which is further converted ",{"id":643,"funder":7,"programme":8,"title":644,"piName":10,"institution":415,"country":27,"year":13,"amount":645,"abstract":646},"cordis-european-research-council-award-835180","Rome and the Coinages of the Mediterranean: 200 BCE to 64 CE","€2,484,832","Silver coinage formed the backbone of state finance in Classical antiquity. The fineness and quality of a coinage is often taken by historians to be a comment on the fiscal health of the issuing state, yet very little is really known about its fineness and chemical composition, and many of the existing analyses are inadequate to answer key questions. Samples for analysis are commonly taken from the surfaces, or from just beneath the surfaces, of silver coins, and these are not representative of ",{"id":648,"funder":7,"programme":8,"title":649,"piName":10,"institution":249,"country":168,"year":13,"amount":21,"abstract":650},"cordis-european-research-council-award-834290","Topological Crystalline Insulator Nanowires","The key challenge in quantum computation is decoherence - the collapse of a quantum state due to local perturbations. In this proposal we address this challenge by developing a new nanomaterials system, which forms the core of a future topological quantum computer. In a topological quantum bit, information is encoded in Majorana modes, which are topologically protected by a local symmetry and therefore have long coherence times.In this project we develop a new state of matter -topological crysta",{"id":652,"funder":7,"programme":8,"title":653,"piName":10,"institution":273,"country":27,"year":13,"amount":654,"abstract":655},"cordis-european-research-council-award-832721","Using CRISPR genome screens and dual transcriptome analyses to dissect host-pathogen interactions in tuberculosis","€2,160,926","With more than 10 million cases annually, tuberculosis (TB) remains a global health problem. TB epidemic is exacerbated by the spread of multidrug-resistant TB. Host-directed therapies (HDTs) can improve immune mechanisms by augmenting the ability of host cells to kill M. tuberculosis (Mtb) or by modulating the immune response to prevent excessive inflammation, cell death and tissue damage. Progress with HDT development has been slowed down by the limited understanding of host-pathogen interacti",{"id":657,"funder":7,"programme":8,"title":658,"piName":10,"institution":273,"country":27,"year":13,"amount":659,"abstract":660},"cordis-european-research-council-award-833296","Audio-based Mobile Health Diagnostics","€2,493,724","Mobile health is becoming the holy grail for affordable medical diagnostics. It has the potential of associating human behaviour with medical symptoms automatically and at early disease stage; it also offers cheap deployment, reaching populations generally not able to afford diagnosis and delivering a level of monitoring so fine which will likely improve diagnostic theory itself. The advancements of technology offer new ranges of sensing and computation capability with the potential of further i",{"id":662,"funder":7,"programme":8,"title":663,"piName":10,"institution":141,"country":27,"year":13,"amount":664,"abstract":665},"cordis-european-research-council-award-834300","Development of novel optogenetic approaches for improving vision in macular degeneration","€1,991,508","In industrialized countries, age-related macular degeneration (AMD) is the leading cause of untreatable blindness. In addition to age-related disease, there are also inherited forms of macular degeneration, such as juvenile-onset Stargardt disease. These conditions, for which there are currently no effective treatments, involve the loss of photoreceptors in the central retina, where a high cone photoreceptor density is responsible for effecting high resolution vision. We recently discovered that",{"id":667,"funder":7,"programme":8,"title":668,"piName":10,"institution":669,"country":386,"year":13,"amount":21,"abstract":670},"cordis-european-research-council-award-834142","Scalable Control of Interconnected Systems","LUNDS UNIVERSITET","Modern society is critically dependent on large-scale networks for services such as energy supply, transportation and communications. The design and control of such networks is becoming increasingly complex, due to their growing size, heterogeneity and autonomy. A systematic theory and methodology for control of large-scale interconnected systems is therefore needed. In an ambitious effort towards this goal, this project will develop rigorous tools for control synthesis, adaptation and verificat",{"id":672,"funder":7,"programme":8,"title":673,"piName":10,"institution":674,"country":675,"year":13,"amount":21,"abstract":676},"cordis-european-research-council-award-833076","A woman's reproductive experience: Long-term implications for chronic disease and death","UNIVERSITETET I BERGEN","NO","Pregnancy complications such as preeclampsia and preterm birth are known to affect infant health, but their influence on mothers long-term health is not well understood. Most previous studies are seriously limited by their reliance on information from the first pregnancy. Often they lack the data to study womens complete reproductive histories. Without a complete reproductive history, the relationship between pregnancy complications and womens long-term health cannot be reliably studied. The Med",{"id":678,"funder":7,"programme":8,"title":679,"piName":10,"institution":517,"country":363,"year":13,"amount":680,"abstract":681},"cordis-european-research-council-award-833280","Flavor Anomalies and the origin of the Yukawa couplings","€2,318,750","Recent experimental results in flavor physics exhibit deviations from the Standard Model predictions that are growing with time, both as far as statistical significance and as far as internal consistency. Understanding the origin of this phenomenon, the so-called “flavor anomalies”, is of paramount importance for a deeper understanding of fundamental interactions. As recently shown by the PI and collaborators, this phenomenon is likely to be intimately related to the long-standing “flavor proble",{"id":683,"funder":7,"programme":8,"title":684,"piName":10,"institution":279,"country":280,"year":13,"amount":685,"abstract":686},"cordis-european-research-council-award-833598","Mechanistic principles of regulation by small RNAs","€2,278,125","Small RNAs (sRNAs) are major regulators of gene expression in bacteria, exerting their regulation in trans by base pairing with target RNAs. Traditionally, sRNAs were considered post-transcriptional regulators, mainly regulating translation by blocking or exposing the ribosome binding site. However, accumulating evidence suggest that sRNAs can exploit the base pairing to manipulate their targets in different ways, assisting or interfering with various molecular processes involving the target RNA",{"id":688,"funder":7,"programme":8,"title":689,"piName":10,"institution":690,"country":108,"year":13,"amount":691,"abstract":692},"cordis-european-research-council-award-834616","Technical and Social Innovations in the Caucasus: between the Eurasian Steppe and the Earliest Cities in the 4th and 3rd millennia BC","DEUTSCHES ARCHAOLOGISCHES INSTITUT","€2,487,875","This project leads to one of the most dynamic regions in prehistory: the Caucasus of the 4th and early 3rd mill. BC. During this vibrant time, basic innovations emerged, which were crucial until the 19th century: wheel and wagon, copper alloys, the potter’s wheel, new breeds of woolly sheep, domestication of the horse, and others. At the same time, massive migrations from the East European steppe during the early 3rd mill. BC changed the European gene pool.The project challenges the still predom",{"id":694,"funder":7,"programme":8,"title":695,"piName":10,"institution":696,"country":27,"year":13,"amount":697,"abstract":698},"cordis-european-research-council-award-786532","Search for New Phenomena, Materials and Applications Using Van Der Waals Assembly of Individual Atomic Planes","THE UNIVERSITY OF MANCHESTER","€2,499,580","Many layered materials can be disassembled into isolated atomic planes, similar to graphite that splits into graphene layers. A few years ago, we demonstrated that such atomic planes – two-dimensional (2D) crystals – can be stacked on top of each other making so-called van der Waals (vdW) heterostructures. This has ignited a new field that is booming and has not disappointed in delivering interesting science. However, research efforts have so far involved only relatively simple structures that a",{"id":700,"funder":7,"programme":8,"title":701,"piName":10,"institution":261,"country":262,"year":13,"amount":21,"abstract":702},"cordis-european-research-council-award-833816","Neuron-associated macrophages in the gut as novel target for the treatment of enteric neuropathies","The gastrointestinal tract has the vital task to digest and absorb ingested food, a complex process requiring coordinated integration of motility, secretion, vascularization and absorption. Thereto the gastrointestinal tract is equipped with its own nervous system, the enteric nervous system (ENS), capable of controlling gut function independently of input from brain or spinal cord. Reduction in number or dysfunction of the neurons within the gut wall, also referred to as enteric neuropathy, sig",{"id":704,"funder":7,"programme":8,"title":705,"piName":10,"institution":706,"country":75,"year":13,"amount":10,"abstract":707},"cordis-european-research-council-award-833801","NOvel Quantum simulators – connectIng Areas","FUNDACIO INSTITUT DE CIENCIES FOTONIQUES","Quantum simulators (QS) are experimental systems that allow mimic hard to simulate models of condensed matter, high energy physics and beyond. QS have various platforms: from ultracold atoms and ions to superconducting qubits. They constitute the important pillar of quantum technologies (QT), and promise future applications in chemistry, material science and optimization problems. Over the last decade, QS were particularly successful in mimicking topological effects in physics (TEP) and in devel",{"id":709,"funder":7,"programme":8,"title":710,"piName":10,"institution":711,"country":363,"year":13,"amount":712,"abstract":713},"cordis-european-research-council-award-833895","Photonic Structural Materials with Controlled Disorder","UNIVERSITE DE FRIBOURG","€2,499,990","Structural colour reflected by photonic materials is typically attributed to highly ordered nanostructures with periodicities on the 100-nm length scale. When investigating structural colour in animals and plants, it is however becoming increasingly evident that brilliant photonic colour can also arise from seemingly disordered morphologies. This is surprising as uncontrolled disorder in photonic materials usually severely degrades their colour response. While some recent theories exist, the eme",{"id":715,"funder":7,"programme":8,"title":716,"piName":10,"institution":717,"country":20,"year":13,"amount":718,"abstract":719},"cordis-european-research-council-award-834634","Cancer Vaccines and Gut Microbiome: a rational approach to optimize  cancer immunotherapy","UNIVERSITA DEGLI STUDI DI TRENTO","€2,450,000","This proposal intends to shed light on the interplay between cancer immunity and gut microbiome as a way to optimize personalized cancer vaccines and immunotherapy. The project originates from two milestone discoveries. First, to be effective cancer immunotherapies have to target CD4+\u002FCD8+ T cell neo-epitopes, which originate from tumor mutations. Second, the gut microbiome influences the effectiveness of anti-PD-1\u002FPD-L1 antibody immunotherapy both in animal models and in humans. We also recentl",{"id":721,"funder":7,"programme":8,"title":722,"piName":10,"institution":391,"country":168,"year":13,"amount":723,"abstract":724},"cordis-european-research-council-award-833964","A theory of global memory systems","€2,375,000","Spontaneous activity accounts for most of what the brain does and is likely to be key for information processing in the brain, but its function is still quite mysterious. Two key spontaneous activity processes are the Default Mode Network, a set of areas that are most markedly connected and active during behavioural idleness, and memory replay, the spontaneous reactivation of neural patterns occurring during experience. I will test the hypothesis that the DMN plays a key role in memory replay pr",{"id":726,"funder":7,"programme":8,"title":727,"piName":10,"institution":728,"country":27,"year":13,"amount":729,"abstract":730},"cordis-european-research-council-award-833290","Ozone dry deposition to the sea surface microlayer","UNIVERSITY OF YORK","€2,479,602","Tropospheric ozone is a significant climate gas and has a major influence on air quality, public health, and food security.  Ozone is lost to the Earth’s surface directly by “dry deposition”, which is an important loss process for this gas.   Since the ocean represents 70% of the surface, uncertainties in the dry deposition to the “sea surface microlayer” (SML) of the ocean translate into large differences in the predicted global ocean dry deposition flux. There has been very limited experimenta",{"id":732,"funder":7,"programme":8,"title":733,"piName":10,"institution":734,"country":735,"year":13,"amount":736,"abstract":737},"cordis-european-research-council-award-833123","New STANDards for seismic assessment  of built cultural HERITAGE","UNIVERSIDADE DO MINHO","PT","€2,968,755","STAND4HERITAGE ambitiously engages in introducing new standards for safeguarding built cultural heritage for the next generations, which is a major societal demand. Due to its large diversity, the accurate description of the structural behaviour of heritage buildings is still an open issue, particularly when subjected to earthquake ground motions. Among the most frequently observed seismic damage mechanisms in these buildings, the out-of-plane of masonry walls is acknowledged as the main cause f",{"id":739,"funder":7,"programme":8,"title":740,"piName":10,"institution":344,"country":75,"year":13,"amount":741,"abstract":742},"cordis-european-research-council-award-787015","Circulating Gender in the Global Enlightenment: Ideas, Networks, Agencies","€2,499,415","Research on the role played by women as actors and by gender as a cultural category has crucially contributed to historiographical revision of the Enlightenment and its legacy to the modern world. However, the perspective adopted has been national or, if comparative, mostly radial. A leap forward is urgent because current circulationist approaches to the Enlightenment tend to forget its key gender dimension and to underplay contributions from Southern Europe. This projects offers, for the first ",{"id":744,"funder":7,"programme":8,"title":745,"piName":10,"institution":746,"country":108,"year":13,"amount":747,"abstract":748},"cordis-european-research-council-award-835102","Mitochondrial Cristae Biogenesis","UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS","€2,286,248","Mitochondrial cristae biogenesis is an enigma ever since the first imaging of mitochondria, the ‘powerhouses’ of eukaryotic cells, by electron microscopy in the 1950s. The mitochondrial cristae, dynamic and structurally conserved invaginations of the mitochondrial inner membrane, are essential for respiratory ATP generation. Thereby, the form and function of the mitochondrial inner membrane are deeply intertwined. Indeed, irregular or disturbed cristae morphologies are believed to cause numerous",{"id":750,"funder":7,"programme":8,"title":751,"piName":10,"institution":752,"country":108,"year":13,"amount":753,"abstract":754},"cordis-european-research-council-award-833613","Mechanism of ATP Dependent Chromatin Modelling and Editing by INO80 Remodellers","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€2,201,875","Nucleosomes, ~147 base pairs of DNA wrapped around an histone protein octamer, package and protect nuclear DNA but also carry important biological information. The position and composition of nucleosomes along chromosomal DNA is a key element of defining the state and identity of a cell. Chromatin remodellers are ATP dependent molecular machines that position, move or edit nucleosomes in a genome wide manner. Collectively, they shape the nucleosome landscape and play central roles in the mainten",{"id":756,"funder":7,"programme":8,"title":757,"piName":10,"institution":758,"country":108,"year":13,"amount":759,"abstract":760},"cordis-european-research-council-award-787929","Speech Acts in Grammar and Discourse","GEISTESWISSENSCHAFTLICHE ZENTREN BERLIN EV","€2,499,945","The SPAGAD project will investigate speech acts, the basic linguistic units with communicative function. It is made possible by recent breakthroughs in our understanding of speech acts as devices to change the world by establishing new commitments and constrain the future development of a conversation.  The project will propose a formal model for speech acts. In the light of this model it will investigate the role of speech acts in three areas. It will elucidate their role in grammar in typologi",{"id":762,"funder":7,"programme":8,"title":763,"piName":10,"institution":764,"country":20,"year":13,"amount":765,"abstract":766},"cordis-european-research-council-award-834861","Spectral and Optimization Techniques for Robust Recovery, Combinatorial Constructions, and Distributed Algorithms","UNIVERSITA COMMERCIALE LUIGI BOCCONI","€1,971,805","In a recovery problem, we are interested in recovering structure from data that contains a mix of combinatorial structure and random noise. In a robust recovery problem, the data may contain adversarial perturbations as well. A series of recent results in theoretical computer science has led to algorithms based on the convex optimization technique of Semidefinite Programming for several recovery problems motivated by unsupervised machine learning. Can those algorithms be made robust?    Sparsifi",{"id":768,"funder":7,"programme":8,"title":769,"piName":10,"institution":770,"country":108,"year":13,"amount":10,"abstract":771},"cordis-european-research-council-award-833365","Electric Interactions and Structural Dynamics of Hydrated Biomolecules Mapped by Ultrafast Vibrational Probes","FORSCHUNGSVERBUND BERLIN EV","Biomolecules exist in an aqueous environment of dipolar water molecules and solvated ions. Their structure and biological function are strongly influenced by electric interactions with the fluctuating water shell and  ion atmosphere. Understanding such interactions at the molecular level is a major scientific challenge; presently, their strengths, spatial range and interplay with other non-covalent interactions are barely known. Going far beyond existing methods, this project introduces the new ",{"id":773,"funder":7,"programme":8,"title":774,"piName":10,"institution":362,"country":363,"year":13,"amount":775,"abstract":776},"cordis-european-research-council-award-832697","Mapping Dispersion Spectroscopically in Large Gas-Phase Molecular Ions","€2,446,125","We use IR spectroscopy of trapped ions in a cryogenic FT-ICR spectrometer to probe non-covalent, “dispersion” interactions in large, gas-phase molecular ions.  We will measure conformational equilibria by N-H frequency shifts, and correlate gas-phase IR frequency to the N-H-N bond angle in an ionic H-bond.  Substituents on “onium” cations can adopt various conformations, whose energies map interaction potentials.  Substituents on their proton-bound dimers interact non-covalently through dispersi",{"id":778,"funder":7,"programme":8,"title":779,"piName":10,"institution":780,"country":108,"year":13,"amount":781,"abstract":782},"cordis-european-research-council-award-788970","Novel Coding Factors in Heart Disease","MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)","€2,319,514","Heart failure has become a worldwide epidemic with more than 23 million people affected resulting in devastating consequences for patients and an enormous burden on health care systems. One in five heart failure patients dies within a year of diagnosis and survival estimates after diagnosis are 50% and 10% at 5 and 10 years, respectively. Despite intensive investigation, the molecular mechanisms leading to heart failure remain poorly understood. We will narrow this critical gap in knowledge by p",{"id":784,"funder":7,"programme":8,"title":785,"piName":10,"institution":786,"country":386,"year":13,"amount":787,"abstract":788},"cordis-european-research-council-award-834166","Customizable Embedded Real-Time Systems:   Challenges and Key Techniques","UPPSALA UNIVERSITET","€2,499,894","Today, many industrial products are defined by software and therefore customizable: their functionalities implemented by software can be modified and extended by dynamic software updates on demand. This trend towards customizable products is rapidly expanding into all domains of IT, including Embedded Real-Time Systems (ERTS) deployed in Cyber-Physical Systems such as cars, medical devices etc. However, the current state-of-practice in safety-critical systems allows hardly any modifications once",{"id":790,"funder":7,"programme":8,"title":791,"piName":10,"institution":792,"country":793,"year":13,"amount":794,"abstract":795},"cordis-european-research-council-award-834141","The Process Improvement Explorer: Automated Discovery and Assessment of Business Process Improvement Opportunities","TARTU ULIKOOL","EE","€2,349,965","Business processes are the operational backbone of modern organizations. Their continuous improvement is key to the achievement of business objectives, be it with respect to efficiency, quality, compliance, or agility. Accordingly, a common task for process analysts is to discover and assess process improvement opportunities, i.e. changes to one or more processes, which are likely to improve them with respect to one or more performance measures. Current approaches to discover process improvement",{"id":797,"funder":7,"programme":8,"title":798,"piName":10,"institution":752,"country":108,"year":13,"amount":799,"abstract":800},"cordis-european-research-council-award-833440","Cross-talk between platelets and immunity - implications for host homeostasis and defense","€2,321,416","The overall aim of the IMMUNOTHROMBOSIS project is to clarify the mechanisms underlying the recently identified synergism between thrombosis and inflammation. Thrombus formation and inflammation are vital host responses that ensure homeostasis, but can also drive cardiovascular disease, including myocardial infarction and stroke, the major causes of death in Europe. My group and others discovered, that thrombosis and inflammation are not to be considered separate processes. They are tightly inte",{"id":802,"funder":7,"programme":8,"title":803,"piName":10,"institution":804,"country":168,"year":13,"amount":805,"abstract":806},"cordis-european-research-council-award-832256","Search for mechanisms to control chiral Majorana modes in superconductors","UNIVERSITEIT LEIDEN","€1,952,759","Quantum mechanics teaches that electrons have a complex wave function, characterized by an amplitude and a phase. As first theorized by Majorana, it is possible in principle for a charge-neutral particle to have a real wave function. Such real fermions, or Majorana fermions, could be robust carriers of quantum information, insensitive to charge noise and other sources of dephasing. With recent experimental developments in topological superconductivity this idea is becoming a reality.Our objectiv",{"id":808,"funder":7,"programme":8,"title":809,"piName":10,"institution":810,"country":363,"year":13,"amount":811,"abstract":812},"cordis-european-research-council-award-833548","Drosophila sechellia: a novel model to investigate nervous system and behavioral evolution","UNIVERSITE DE LAUSANNE","€2,327,547","How animals’ extraordinarily diverse behaviors have evolved is unknown. Relating interspecific behavioral differences to anatomical or physiological distinctions in neural circuits, and causal genetic variation, offers a powerful approach to inform how nervous systems develop, function and change.Understanding behavioral and nervous system evolution requires deep investment in select species. We propose to establish a new model neurogenetic system: Drosophila sechellia, an island endemic that is",{"id":814,"funder":7,"programme":8,"title":815,"piName":10,"institution":581,"country":27,"year":13,"amount":816,"abstract":817},"cordis-european-research-council-award-834631","Precision Docking of Very Large DNA Cargos in Mammalian Genomes","€2,498,578","Gene editing has developed at breath-taking speed. In particular CRISPR\u002FCas9 provides a tool-set thousands of researchers worldwide now utilize with unprecedented ease to edit genes, catalysing a broad range of biomedical and industrial applications. Gene synthesis technologies producing thousands of base pairs of synthetic DNA have become affordable. Current gene editing technology is highly effective for local, small genomic DNA edits and insertions.  To unlock the full potential of this revol",{"id":819,"funder":7,"programme":8,"title":820,"piName":10,"institution":141,"country":27,"year":13,"amount":821,"abstract":822},"cordis-european-research-council-award-787971","Cardiac REgeneration from within","€2,428,492","Biotechnological therapies for patients with myocardial infarction and heart failure are urgently needed, in light of the breadth of these diseases and a lack of curative treatments. CuRE is an ambitious project aimed at identifying novel factors (cytokines, growth factors, microRNAs) that promote cardiomyocyte proliferation and can thus be transformed into innovative therapeutics to stimulate cardiac regeneration. The Project leads from two concepts: first, that cardiac regeneration can be obta",{"id":824,"funder":7,"programme":8,"title":825,"piName":10,"institution":826,"country":27,"year":13,"amount":827,"abstract":828},"cordis-european-research-council-award-789119","Remote control healing: Next generation mechano-nano-therapeutics","THE UNIVERSITY OF BIRMINGHAM","€2,499,068","Imagine if doctors could heal patients via remote control. Following simple injections into regions of the body, they could activate internal cells by an external bandage. In this way, they could remotely control the ways tissue heal. This Advanced grant sets out to understand, design and develop the mechano-nano-magnetic platform that will underpin this therapeutic strategy for the future – DYNACEUTICS. Key receptors have been identified such as ion channels, integrins and growth factors which ",{"id":830,"funder":7,"programme":8,"title":831,"piName":10,"institution":832,"country":108,"year":13,"amount":833,"abstract":834},"cordis-european-research-council-award-834267","Amenability, Approximation and Reconstruction","UNIVERSITAET MUENSTER","€1,596,017","Algebras of operators on Hilbert spaces were originally introduced as the right framework for the mathematical description of quantum mechanics. In modern mathematics the scope has much broadened due to the highly versatile nature of operator algebras. They are particularly useful in the analysis of groups and their actions.  Amenability is a finiteness property which occurs in many different contexts and which can be characterised in many different ways. We will analyse amenability in terms of ",{"id":836,"funder":7,"programme":8,"title":837,"piName":10,"institution":397,"country":280,"year":13,"amount":838,"abstract":839},"cordis-european-research-council-award-833031","Reconstructing the emergence of the Milky Way’s stellar population with Gaia, SDSS-V and JWST","€1,859,375","Understanding how the Milky Way arrived at its present state requires a large volume of precision measurements of our Galaxys current makeup, as well as an empirically based understanding of the main processes involved in the Galaxys evolution. Such data are now about to arrive in the flood of quality information from Gaia and SDSS-V. The demography of the stars and of the compact stellar remnants in our Galaxy, in terms of phase-space location, mass, age, metallicity, and multiplicity are data ",{"id":841,"funder":7,"programme":8,"title":842,"piName":10,"institution":500,"country":108,"year":13,"amount":843,"abstract":844},"cordis-european-research-council-award-834940","Ultra-Fast, Spread-Spectrum Magnetic Resonance Imaging","€2,780,760","Imaging speed is a key factor to capture rapid changes at high spatial and temporal resolution. A major limitation of magnetic resonance (MR) imaging is its rather low speed compared to other modalities like ultra sound or computerized tomography. We aim to explore two novel concepts to boost MR imaging speed by another order of magnitude compared to existing techniques. SpreadMRI fundamentally steps beyond current concepts of image encoding by exploiting a spectral spin modulation that so far h",{"id":846,"funder":7,"programme":8,"title":847,"piName":10,"institution":848,"country":75,"year":13,"amount":849,"abstract":850},"cordis-european-research-council-award-788986","The Sources of Absolute Music: Mapping Emotions in Eighteenth-Century Italian Opera","UNIVERSIDAD COMPLUTENSE DE MADRID","€2,498,690","The belief that ‘the end of music is to move human affections’ (Descartes, Compendium musicae) has been a central issue in European musical thought since Plato. Opera was invented to recover the power of Ancient music to move the human heart, and its history is a permanent exploration of the capacity of action, words and music to convey emotions. In the eighteenth century a new type of opera consolidated with the chief concern of expressing the character’s emotions as they changed throughout the",{"id":852,"funder":7,"programme":8,"title":853,"piName":10,"institution":854,"country":46,"year":13,"amount":21,"abstract":855},"cordis-european-research-council-award-833707","Supramolecular engineering of multifunctional systems and devices: the molecular approach to 2D materials","CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION","SUPRA2DMAT is a multidisciplinary project aimed at exploiting materials engineering, by mastering supramolecular approaches, to combine the outstanding physico-chemical properties of graphene and other 2D layered materials (2DLMs) with the chemical and functional programmability of molecular components, with the ultimate goal of modulating and enhancing the properties of 2DLMs and imparting them a responsive nature. The monolayer nature of 2DLMs makes them extremely sensitive to environmental ch",{"id":857,"funder":7,"programme":8,"title":858,"piName":10,"institution":717,"country":20,"year":13,"amount":859,"abstract":860},"cordis-european-research-council-award-833504","Number-space associations in the brain","€2,628,333","Research in cognitive science has revealed that the temporal, spatial, and numerical features of a stimulus can interact with one another. An example is the tendency to map increasing numerical magnitudes with a left-to-right orientation. Numerical-spatial associations (NSA) are pervasive in human behaviour and have relevance to health (e.g., dyscalculia is thought to be related to improper understanding of the so-called «mental number line»). NSA have been shown to occur in human newborns and i",{"id":862,"funder":7,"programme":8,"title":863,"piName":10,"institution":391,"country":168,"year":13,"amount":864,"abstract":865},"cordis-european-research-council-award-834441","Rewriting Global Orthodoxy Oriental Christianity in Europe between 1970 and 2020","€2,467,260","Over the last fifty years, Oriental Orthodox Christians (Armenians, Copts, Syriacs\u002FArameans, Ethiopians and Eritreans) from the Middle East and Africa have settled in Europe, fleeing war-related violence and societal pressures. One of the prominent aspects of religious practice of these transnational Oriental communities is their strong emphasis on the writing and publishing of texts. These include traditional religious texts (from liturgy to history), re-translated and re-contextualized texts, ",{"id":867,"funder":7,"programme":8,"title":868,"piName":10,"institution":869,"country":363,"year":13,"amount":870,"abstract":871},"cordis-european-research-council-award-787703","Self-assessment Oracles for Anticipatory Testing","UNIVERSITA DELLA SVIZZERA ITALIANA","€2,313,250","One of the long-lasting dreams in science fiction is the ability to arrest criminals before they even commit crimes. Software testing researchers have a similar dream: when the context for a bug manifestation occurs in the field, the goal is to discover and fix the bug before it causes any in-field failure. In fact, current practice of pre-release testing is severely limited when dealing with autonomous AI (Artificial Intelligence) systems (such as self-driving cars, robots, automated traders, v",{"id":873,"funder":7,"programme":8,"title":874,"piName":10,"institution":331,"country":108,"year":13,"amount":875,"abstract":876},"cordis-european-research-council-award-788196","Suspended Life: Exploring Cryopreservation Practices in Contemporary Societies","€2,497,587","Cryopreservation practices are an essential dimension of contemporary life sciences. They make possible the freezing and storage of cells, tissues and other organic materials at very low temperatures and the subsequent thawing of these at a future date without apparent loss of vitality. Although cryotechnologies are fundamental to reproductive technologies, regenerative medicine, transplantation surgery and conservation biology, they have largely escaped scholarly attention in science and techno",{"id":878,"funder":7,"programme":8,"title":879,"piName":10,"institution":500,"country":108,"year":13,"amount":880,"abstract":881},"cordis-european-research-council-award-786672","Promoting Osteogenesis through Vascular Endothelial Cells","€2,205,875","The skeletal system and its vasculature form a functional unit with great relevance in health, regeneration, and disease. Our recent work has provided fundamental insights into the organization of the bone vasculature in mouse, its changes during aging, the heterogeneity and functional specialization of bone capillaries and endothelial cells, the regulation of these properties by Notch and hypoxia-inducible factor signaling, and the crosstalk with osteoblast lineage cells. Most importantly, we f",{"id":883,"funder":7,"programme":8,"title":884,"piName":10,"institution":885,"country":108,"year":13,"amount":886,"abstract":887},"cordis-european-research-council-award-786487","Inverted Reactive Spray Processes for Sulphide\u002FNitride High Surface Area Electrode Coatings","UNIVERSITAET BREMEN","€2,361,130","Highly pure, binary and ternaty metal sulphides\u002Fnitrides are increasingly important materials for energy storage, electrocatalysis, optoelectronics and battery materials. To fully use their potential, radical new technologies that allow the synthesis of complex, and multicomponent crystalline materials with specific size and morphology are required. While the reactive spray technology is already a key element for the scalable and economic synthesis of metal oxides, we will fundamentally advance ",{"id":889,"funder":7,"programme":8,"title":890,"piName":10,"institution":397,"country":280,"year":13,"amount":891,"abstract":892},"cordis-european-research-council-award-835152","Challenging Computational Infeasibility: PCP and Boolean functions","€2,059,375","Computer Science, in particular, Analysis of Algorithms and Computational-Complexity theory, classify algorithmic-problems into feasible ones and those that cannot be efficiently-solved. Many fundamental problems were shown NP-hard, therefore, unless P=NP, they are infeasible.Consequently, research efforts shifted towards approximation algorithms, which find close-to-optimal solutions for NP-hard optimization problems.The PCP Theorem and its application to infeasibility of approximation establis",{"id":894,"funder":7,"programme":8,"title":895,"piName":10,"institution":62,"country":46,"year":13,"amount":896,"abstract":897},"cordis-european-research-council-award-832601","Cells and giant viruses: a win-win co-evolution","€2,246,453","The discovery of Mimivirus, the first icosahedral virus visible by light microscopy, was followed by the characterization of many other relatives. Its aquatic relative Megavirus chilensis, has a 1.2 Mb genome and encodes more than 1000 proteins, 2\u002F3 unique to the Mimiviridae. Their infectious cycle is cytoplasmic. During the last 10 years, my laboratory discovered three other giant virus families: -the pandoraviridae, with their unique amphora-shaped 1m long virion morphologies, genome sizes rea",{"id":899,"funder":7,"programme":8,"title":900,"piName":10,"institution":62,"country":46,"year":13,"amount":901,"abstract":902},"cordis-european-research-council-award-787399","Data-intensive analysis of seismic tremors and long period events: a new paradigm for understanding transient deformation processes in active geological systems","€2,490,000","Seismic tremors form a broad class of signals generated by internal sources that are different from regular earthquakes. Volcanic tremors have been known for a long time, and tectonic tremors associated with seismogenic fault zones have been described more recently. While the physical origin of seismic tremors remains to be fully understood, they are related to slow transient energy release processes that occur in active geological systems during the accumulation of mechanical energy that is the",{"id":904,"funder":7,"programme":8,"title":905,"piName":10,"institution":906,"country":262,"year":13,"amount":907,"abstract":908},"cordis-european-research-council-award-788734","Counting as a Human Being in the Era of Computational Law","VRIJE UNIVERSITEIT BRUSSEL","€2,492,433","This project will investigate how the prominence of counting and computation transforms many of the assumptions, operations and outcomes of the law. It targets two types of computational law: artificial legal intelligence or data-driven law (based on machine learning), and cryptographic or code-driven law (based on blockchain technologies). Both disrupt, erode and challenge conventional legal scholarship and legal practice. The core thesis of the research is that the upcoming integration of comp",{"id":910,"funder":7,"programme":8,"title":911,"piName":10,"institution":427,"country":168,"year":13,"amount":21,"abstract":912},"cordis-european-research-council-award-833867","Directions in Development","Cells in multicellular organisms organise along body and tissue axes. Cellular processes, such as division plane orientation, must be aligned with these polarity axes to generate functional 3-dimensional morphology, particularly in plants, where cell walls prevent cell migration. While some polarly localized plant proteins are known, molecular mechanisms of polarity establishment or its translation to division orientation are elusive, in part because regulators in animals and fungi appear to be ",{"id":914,"funder":7,"programme":8,"title":915,"piName":10,"institution":696,"country":27,"year":13,"amount":916,"abstract":917},"cordis-european-research-council-award-786630","Molecular Machines with Integrated Parts","€2,471,095","The widespread use of molecular-level motion in key natural processes suggests that great rewards could come from bridging the gap between the present generation of synthetic molecular machines—which by and large rely upon switching of individual components to carry out their functions—and the machines of the macroscopic world, which utilize the synchronized behaviour of integrated components to perform tasks more complex than the sum of the components. The aim of this project is to learn how to",{"id":919,"funder":7,"programme":8,"title":920,"piName":10,"institution":397,"country":280,"year":13,"amount":921,"abstract":922},"cordis-european-research-council-award-786758","Random Models in Arithmetic and Spectral Theory","€1,840,625","The proposal studies deterministic problems in the spectral theory of the Laplacian and in analytic number theory by using random models. I propose two projects in spectral theory on this theme, both with a strong arithmetic ingredient, the first about minimal gaps between the eigenvalues of the Laplacian, where I seek a fit with the corresponding quantities for the various conjectured universality classes (Poisson\u002FGUE\u002FGOE), and the second about curvature measures of nodal lines of eigenfunction",{"id":924,"funder":7,"programme":8,"title":925,"piName":10,"institution":432,"country":27,"year":13,"amount":21,"abstract":926},"cordis-european-research-council-award-834692","Targeting RAS driven tumour immune evasion","Mutations in RAS oncogenes are responsible for driving some 20% of all human malignancies, occurring in many major killers, such as lung, pancreatic, and colon cancers, but attempts to develop therapeutic interventions for RAS mutant cancers have yet to provide clinical benefit. By inhibiting pathways downstream of RAS along with other key signaling nodes, we have developed combination therapies that cause major regression of KRAS mutant lung cancer in mouse models. However, a major limitation i",{"id":928,"funder":7,"programme":8,"title":929,"piName":10,"institution":500,"country":108,"year":13,"amount":21,"abstract":930},"cordis-european-research-council-award-833404","Kinetics and Dynamics at Surfaces","This proposal implements slice imaging to measure catalytic rates for site-specific elementary reactions thus offering remarkable opportunities to advance our fundamental understanding of heterogeneous catalysis.  As evidence for global climate change continues to grow, catalysis has moved to the front line of the struggle to obtain new, sustainable technologies for the future.  Catalysis and catalytic processes account, directly or indirectly, for 20-30 % of world Gross Domestic Product.  Knowl",{"id":932,"funder":7,"programme":8,"title":933,"piName":10,"institution":261,"country":262,"year":13,"amount":934,"abstract":935},"cordis-european-research-council-award-833577","Resolving Precariousness: Advancing the Theory and Measurement of Precariousness across the paid\u002Funpaid work continuum","€2,486,875","The traditional dichotomy of paid (productive or waged) versus unpaid (reproductive or unwaged) work marginalizes unpaid work when conceptualizing precariousness, i.e. the exposure to unpredictability towards an individual’s future. It also neglects several types of unpaid work such as care work, work as a precondition for welfare payments, and newly emerging on- and offline work in the gig economy for which people in paid work are not compensated or where it is used to access paid work. A novel",{"id":937,"funder":7,"programme":8,"title":938,"piName":10,"institution":350,"country":27,"year":13,"amount":10,"abstract":939},"cordis-european-research-council-award-789100","GLOBAL REMUNICIPALISATION AND THE POST-NEOLIBERAL TURN","This project will undertake a transnational comparative study investigating the phenomenon of remunicipalisation. This refers to a global trend since 2000 (involving 835 cases in 45 countries) for cities to take formerly privatised assets, infrastructure and services back into public ownership. As such, it marks a significant departure in existing urban governance processes, signaling a decisive shift against the dominant form of neoliberalism that has held sway since the 1980s. The research adv",{"id":941,"funder":7,"programme":8,"title":942,"piName":10,"institution":26,"country":27,"year":13,"amount":10,"abstract":943},"cordis-european-research-council-award-834999","Making Africa Urban: The transcalar politics of large-scale urban development","This project will investigate how urban futures  are made through different global circuits and in turn shape key transnational processes: geopolitics, development and private investment, through a close focus on the transnational actors and decision-making processes involved in large-scale developments and interventions in selected African cities. The research will produce: new theoretical perspectives on urban politics and policy-relevant understandings of state capacity and land value capture",{"id":945,"funder":7,"programme":8,"title":946,"piName":10,"institution":947,"country":27,"year":13,"amount":10,"abstract":948},"cordis-european-research-council-award-834103","Understanding Life Trajectories of Immigrants and Their Descendants in Europe and Projecting Future Trends","THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS","In recent decades, European countries have witnessed increasing immigration streams and ethnic heterogeneity of their populations. Facilitating immigrant integration and social cohesion has become a major societal issue. The project moves beyond previous research by first investigating how employment, housing and family trajectories evolve and interact in the lives of descendants of post-WWII immigrants and post-1990 immigrants in the UK, France, Germany and Sweden, and how factors related to a ",{"id":950,"funder":7,"programme":8,"title":951,"piName":10,"institution":952,"country":20,"year":13,"amount":10,"abstract":953},"cordis-european-research-council-award-833824","GAs Stripping Phenomena in galaxies","ISTITUTO NAZIONALE DI ASTROFISICA","The build up of galaxies is mainly driven by the availability of gas that can cool and form new stars. Any physical process that is able to alter the gas content of a galaxy has therefore important consequences for its evolution. The study of processes that can remove gas from galaxies is the subject of GASP (GAs Stripping Phenomena in galaxies), an ESO Large Program I am leading. GASP has obtained integral field spectroscopy (IFS) with MUSE of 114 low-z galaxies with masses in the range 10^9-10",{"id":955,"funder":7,"programme":8,"title":956,"piName":10,"institution":286,"country":168,"year":13,"amount":10,"abstract":957},"cordis-european-research-council-award-834716","Sustainability, efficiency, equity and resilience of land and water use  for global food and energy security: synergies and fundamental trade-offs","Humanity faces major challenges: stay below local and global ecological thresholds; increase natural resources use efficiency; share resources fairly; and increase societal resilience. Most research focusses on one or two of these challenges at a time; there is a major scientific gap in understanding synergies and inevitable trade-offs between the development principles of environmental sustainability, equitability, efficiency and resilience.  This project aims to analyse synergies and trade-off",{"id":959,"funder":7,"programme":8,"title":960,"piName":10,"institution":362,"country":363,"year":13,"amount":961,"abstract":962},"cordis-european-research-council-award-833540","Development of Stereoselective Olefin Functionalization Methods","€2,498,635","The ability toThe ability to readily access small-molecule building blocks at will has important consequences for the discovery and development of novel medicines and materials.  It is particularly beneficial when the chemical methods are convenient while at the same time economically and environmentally tenable and sustainable. We are especially interested in catalytic processes that are easily executed and utilize readily available starting materials to produce optically active products with h",{"id":964,"funder":7,"programme":8,"title":965,"piName":10,"institution":966,"country":20,"year":13,"amount":967,"abstract":968},"cordis-european-research-council-award-834033","An-Iconology: History, Theory, and Practices of Environmental Images","UNIVERSITA DEGLI STUDI DI MILANO","€2,328,736","Recent developments in image-making techniques have resulted in a drastic blurring of the threshold between the world of the image and the real world. Immersive and interactive virtual environments have enabled the production of pictures that elicit in the perceiver a strong feeling of being incorporated in a quasi-real world. In doing so such pictures conceal their mediateness (their being based on a material support), their referentiality (their pointing to an extra-iconic dimension), and thei",{"id":970,"funder":7,"programme":8,"title":971,"piName":10,"institution":972,"country":386,"year":13,"amount":973,"abstract":974},"cordis-european-research-council-award-787386","The Unity of the Bodily Self","KAROLINSKA INSTITUTET","€2,583,560","How do we come to experience ourselves as single physical entities? Under normal healthy conditions, we humans always experience a single body as our own physical self, and this bodily self is undivided and perceived as a single whole. But what cognitive processes and brain mechanisms mediate this unity of the bodily self? This fundamental question has long been beyond the reach of experimental studies because of the lack of behavioral paradigms that allow controlled manipulation of basic compon",{"id":976,"funder":7,"programme":8,"title":977,"piName":10,"institution":978,"country":386,"year":13,"amount":979,"abstract":980},"cordis-european-research-council-award-834677","Electronic Neuropharmacology","LINKOPINGS UNIVERSITET","€3,237,335","As the population ages, neurodegenerative diseases (ND) will have a devastating impact on individuals and society. Despite enormous research efforts there is still no cure for these diseases, only care! The origin of ND is hugely complex, spanning from the molecular level to systemic processes, causing malfunctioning of signalling in the central nervous system (CNS). This signalling includes the coupled processing of biochemical and electrical signals, however current approaches for symptomatic-",{"id":982,"funder":7,"programme":8,"title":983,"piName":10,"institution":984,"country":46,"year":13,"amount":985,"abstract":986},"cordis-european-research-council-award-835193","Reappraising Western European Repertoires for Puppet and Marionette Theatres","Université de Montpellier Paul-Valéry","€2,288,832","This project aims at transcending boundaries between « high » and « popular » cultures, here established playwrights and anonymous writers, by investigating their productions for a same medium: puppet and marionette theatre. Focusing on key-periods of drama history (1600-2000) it explores how puppeteers and authors both contribute to the raise of a specific dramaturgy. Introducing these repertoires into the history of Western European drama opens a double ground-breaking perspective: on one side",{"id":988,"funder":7,"programme":8,"title":989,"piName":10,"institution":391,"country":168,"year":13,"amount":21,"abstract":990},"cordis-european-research-council-award-833466","Life-inspired complex molecular systems controlled by enzymatic reaction networks","Many of the key functions typically associated with living systems, including sensing of the environment, autonomous decision making, and extracting energy and building blocks from the environment for cell growth and division, are all governed by enzymatic reaction networks. Constructing synthetic systems that capture some of these capabilities, i.e. life-inspired systems, would represent a truly disruptive development, as they challenge our notion of what differentiates living systems from synt",{"id":992,"funder":7,"programme":8,"title":993,"piName":10,"institution":350,"country":27,"year":13,"amount":994,"abstract":995},"cordis-european-research-council-award-835197","ViAjeRo: Virtual and Augmented Reality passenger experiences","€2,443,657","ViAjeRo will radically improve passenger journeys using immersive Virtual and Augmented Reality to support entertainment, work and collaboration on the move. In Europe, people travel an average of 12,000km per year on private and public transport, in cars, buses, planes and trains. These journeys are often repetitive and wasted time. This total will rise with the arrival of fully autonomous cars, which free drivers to become passengers. The potential to recover this lost time is impeded by 3 sig",{"id":997,"funder":7,"programme":8,"title":998,"piName":10,"institution":999,"country":168,"year":13,"amount":21,"abstract":1000},"cordis-european-research-council-award-834618","Programmable ARTificial immune systems to fight cancer","STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM","Immunotherapy has entered centre stage as a novel treatment modality for cancer. Notwithstanding this major step forward, toxicity and immunosuppression remain major obstacles, and illustrate the pressing need for more powerful and specific immunotherapies against cancer. To overcome these roadblocks, in ARTimmune, I propose to follow a radically different approach by developing local rather than systemic immunotherapies. Taking advantage of the architecture of a lymph node (LN), I aim to design",{"id":1002,"funder":7,"programme":8,"title":1003,"piName":10,"institution":279,"country":280,"year":13,"amount":1004,"abstract":1005},"cordis-european-research-council-award-788890","Factorizing the wave function of large quantum systems","€2,443,932","This proposal puts forth a novel strategy to tackle large quantum systems. A variety of highly sophisticated methods such as quantum Monte Carlo, configuration interaction, coupled cluster, tensor networks, Feynman diagrams, dynamical mean-field theory, density functional theory, and semi-classical techniques have been developed to deal with the enormous complexity of the many-particle Schrödinger equation. The goal of our proposal is not to add another method to these standard techniques but, i",{"id":1007,"funder":7,"programme":8,"title":1008,"piName":10,"institution":1009,"country":280,"year":13,"amount":1010,"abstract":1011},"cordis-european-research-council-award-833078","Statistics of Exotic Fractional Hall States","WEIZMANN INSTITUTE OF SCIENCE","€1,801,094","Since their discovery, Quantum Hall Effects have unfolded intriguing avenues of research, exhibiting a multitude of unexpected exotic states: accurate quantized conductance states; particle-like and hole-conjugate fractional states; counter-propagating charge and neutral edge modes; and fractionally charged quasiparticles - abelian and (predicted) non-abelian. Since the sought-after anyonic statistics of fractional states is yet to be verified, I propose to launch a thorough search for it employ",{"id":1013,"funder":7,"programme":8,"title":1014,"piName":10,"institution":1015,"country":108,"year":13,"amount":1016,"abstract":1017},"cordis-european-research-council-award-832480","Degradable Polyolefin Materials Enabled by Catalytic Methods","UNIVERSITAT KONSTANZ","€2,494,829","Plastics are essential to virtually any modern technology and therefore ubiquitious. However, when released to the environment they can persist for centuries. One pillar of a responsible future economy is therefore to endow important plastics with a non-persistent nature. Polyethylene (PE) is the largest scale synthetic material, used in transportation, energy storage, water cleaning, clothing and many other fields. However, it is most problematic concerning degradability.  This proposal address",{"id":1019,"funder":7,"programme":8,"title":1020,"piName":10,"institution":500,"country":108,"year":13,"amount":21,"abstract":1021},"cordis-european-research-council-award-832848","Revealing Fundamental Interactions and their Symmetries at the highest Precision and the lowest Energies","The four fundamental interactions and their symmetries, the fundamental constants as well as the properties of elementary particles like masses and moments, determine the basic structure of the universe and are the basis for our so well tested Standard Model (SM) of physics. Performing stringent tests on these interactions and symmetries in extreme conditions at lowest energies and with highest precision by comparing e.g. the properties of particles and their counterpart, the antiparticles, will",{"id":1023,"funder":7,"programme":8,"title":1024,"piName":10,"institution":1025,"country":735,"year":13,"amount":1026,"abstract":1027},"cordis-european-research-council-award-833438","Making the Earth Global: Early Modern Nautical Rutters and the Construction of a Global Concept of the Earth","FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA","€2,078,331","Early modern nautical rutters (sailing directions) are the earliest Western documents that testify to the stable and regular lived experience of traversing the earth’s oceans on a global, planetary scale. Nautical rutters (and ship’s loogbooks) are technical documents that collect and analyse critical information for the successful accomplishment of oceanic navigation. This includes elements of strict nautical nature (courses, distances, and latitudes), as well as information on oceanography (cu",{"id":1029,"funder":7,"programme":8,"title":1030,"piName":10,"institution":500,"country":108,"year":13,"amount":1031,"abstract":1032},"cordis-european-research-council-award-832428","From Planet-Forming Disks to Giant Planets","€2,474,252","Planet-forming disks around young stars display a large variety of spatial structures indicating pattern formation by gas-dust dynamics and planet-disk interactions. The diversity of planetary properties point to different physical and chemical conditions in their parental disks and a range of formation pathways. Currently, there is no unifying approach which connects disk physics and chemistry with exoplanet properties. The development of such a link remains a considerable challenge as long as ",{"id":1034,"funder":7,"programme":8,"title":1035,"piName":10,"institution":1036,"country":27,"year":13,"amount":1037,"abstract":1038},"cordis-european-research-council-award-833254","Mechanistic basis of nucleation and spreading underlying a Polycomb-mediated epigenetic switch","JOHN INNES CENTRE","€2,101,325","Polycomb-mediated epigenetic regulation of gene expression is central to development and environmental plasticity in most eukaryotes. Polycomb Repressive Complex 2 (PRC2) is targeted to genomic sites, known as nucleation regions or Polycomb Response elements, and switches those targets to an epigenetically silenced state. But what constitutes the switching mechanism is unknown. Core epigenetic switching mechanisms have proven difficult to elucidate due to the complex molecular feedbacks involved",{"id":1040,"funder":7,"programme":8,"title":1041,"piName":10,"institution":26,"country":27,"year":13,"amount":1042,"abstract":1043},"cordis-european-research-council-award-833135","ETHNO-ISS: An Ethnography of an Extra-terrestrial Society: the International Space Station","€2,475,251","The International Space Station (ISS) is arguably the oldest extra-terrestrial society in low earth orbit. To date this radical new form of human habitation and society has not been the object of systematic and comparative ethnographic inquiry. This project aims to correct this and proposes a comparative and multi-sited ethnography of the ISS among the contributors to its modular architecture: The Russian Federation, The United States of America, The European Union and Japan. The ISS offers inva",{"id":1045,"funder":7,"programme":8,"title":1046,"piName":10,"institution":1047,"country":363,"year":13,"amount":1048,"abstract":1049},"cordis-european-research-council-award-834402","Ultra-sensitive mechanical dissipation in classical, quantum and non-equilibrium nanocontacts","UNIVERSITAT BASEL","€2,002,833","Dissipation spectroscopy: Nanomechanical dissipation, experienced by oscillating tip-based Force Microscopy (AFM) instruments, provides an innovative probe of the physics of classical and quantum materials, solids, surfaces. My group made, in the last decade, well-recognized experimental and conceptual advances by exploiting and adapting advanced AFM techniques, especially the ultra-sensitive pendulum-AFM, (p-AFM, dissipation sensitivity ~0.1 aW, force sensitivity ~ 10-12N) detecting collective ",{"id":1051,"funder":7,"programme":8,"title":1052,"piName":10,"institution":1053,"country":262,"year":13,"amount":1054,"abstract":1055},"cordis-european-research-council-award-835133","Ultra-Bright Thin-Film Light Emitting Devices and Lasers","INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM","€2,497,493","Thin-film light sources such as OLEDs are extremely valuable, as, in contrast to III-V crystalline LEDs, they can be precisely designed and dimensioned, as single components or in massive arrays, into any target application without the need of hetero-assembly. Unfortunately, their light power density remains about 300 times smaller than that of III-V LEDs. Also, none of today’s thin-film light sources could ever be brought to lasing by electrical pumping.It is the objective of this project to br",{"id":1057,"funder":7,"programme":8,"title":1058,"piName":10,"institution":999,"country":168,"year":13,"amount":21,"abstract":1059},"cordis-european-research-council-award-833247","Trained immunity: improving the next generation of vaccines for the older generation","The host defense, especially the adaptive immunity, is defective in the elderly, with a dramatic drop for the efficacy of vaccination with old age. Interestingly however, the innate immunity of older individuals is relatively intact, and we recently described that epigenetic and functional reprogramming of innate immune cells by certain vaccines and mild infections, termed ‘trained immunity’, induces potent heterologous protection against infections. I propose that induction of trained immunity ",{"id":1061,"funder":7,"programme":8,"title":1062,"piName":10,"institution":279,"country":280,"year":13,"amount":1063,"abstract":1064},"cordis-european-research-council-award-833694","A neuro-computational account of success and failure in acquiring communication skills","€2,499,888","Why do most people acquire expertise with practice whereas others fail to master the same tasks? NeuroCompSkill offers a neuro-computational framework that explains failure in acquiring verbal and non-verbal communication skills. It focuses on individual ability of using task-relevant regularities, postulating that efficient use of such regularities is crucial for acquiring expertise. Specifically, it proposes that using stable temporal regularities, acquired across long time windows (> 3 sec to",{"id":1066,"funder":7,"programme":8,"title":1067,"piName":10,"institution":1068,"country":27,"year":13,"amount":10,"abstract":1069},"cordis-european-research-council-award-787768","In search of uniqueness - harnessing anatomical hand variation","UNIVERSITY OF LANCASTER","H-unique will be the first multimodal automated interrogation of visible hand anatomy, through analysis and interpretation of human variation. It will be an interdisciplinary project, supported by anatomists, anthropologists,  geneticists, bioinformaticians, image analysts and computer scientists. We will investigate inherent and acquired variation in search of uniqueness, as the hand retains and displays a multiplicity of anatomical variants formed by different aetiologies (genetics, developmen",{"id":1071,"funder":7,"programme":8,"title":1072,"piName":10,"institution":325,"country":262,"year":13,"amount":1073,"abstract":1074},"cordis-european-research-council-award-833866","A NOVEL BREEDING STRATEGY USING MULTIPLEX GENOME EDITING IN MAIZE","€2,474,790","Feeding the growing world population under changing climate conditions poses an unprecedented challenge on global agriculture and our current pace to breed new high yielding crop varieties is too low to face the imminent threats on food security. This ERC project proposes a novel crossing scheme that allows for an expeditious evaluation of combinations of potential yield contributing alleles by unifying ‘classical’ breeding with gene-centric molecular biology. The acronym BREEDIT, a word fusion ",{"id":1076,"funder":7,"programme":8,"title":1077,"piName":10,"institution":826,"country":27,"year":13,"amount":1078,"abstract":1079},"cordis-european-research-council-award-786198","Extremal Combinatorics: existence, counting and typical structure","€1,797,111","A central theme of extremal combinatorics is the interplay and relationship between the parameters of combinatorial objects. The first and most immediate question which arises in this context is that of the (i) existence of objects with a given set of parameters. Once this has been answered, the next step is to seek for (ii) the number of such objects - i.e. to ask for a counting result. This is of central importance in the context of many combinatorial questions arising in statistical physics. ",{"id":1081,"funder":7,"programme":8,"title":1082,"piName":10,"institution":362,"country":363,"year":13,"amount":1083,"abstract":1084},"cordis-european-research-council-award-833848","Unravelling Earth’s magnetic history and processes","€2,494,725","We wish to understand how magnetic fields are generated in the cores of planets. This process is called the dynamo mechanism, whose understanding remains one of the geophysical grand challenges. In cores of rocky planets and in gas giants, thermal forcing results in convection and the resulting flow of liquid metal transports heat and generates magnetic fields as a result of the electrical currents that are induced by their motion. Magnetic field generation affects heat transport and cooling, co",{"id":1086,"funder":7,"programme":8,"title":1087,"piName":10,"institution":1088,"country":168,"year":13,"amount":1089,"abstract":1090},"cordis-european-research-council-award-832844","Breaking borders, Functional genetic screens of structural regulatory DNA elements","STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS","€2,497,000","The human genome carries genetic information in two distinct forms: Transcribed genes and regulatory DNA elements (rDEs). rDEs control the magnitude and pattern of gene expression, and are indispensable for organismal development and cellular homeostasis. Nevertheless, while large-scale functional genetic screens greatly advanced our knowledge in studying mammalian genes, such tools to study rDEs were lacking, impeding scientific progress. Interestingly, recent advance in genome editing technolo",{"id":1092,"funder":7,"programme":8,"title":1093,"piName":10,"institution":1094,"country":363,"year":13,"amount":1095,"abstract":1096},"cordis-european-research-council-award-787935","Gangs, Gangsters, and Ganglands: Towards a Global Comparative Ethnography","FONDATION POUR L INSTITUT DE HAUTES ETUDES INTERNATIONALES ET DU DEVELOPPEMENT","€2,498,079","Gangs occupy a key position in the global imaginary of violence, widely perceived and represented as primary sources of brutality and insecurity. This can be related to the fact that they are one of a small number of truly global phenomena, found in almost every society across both time and space. At the same time, however, as almost 100 years of gang research have highlighted, the phenomenon can vary significantly in form, dynamics, and consequences. While there have been many insightful studie",{"id":1098,"funder":7,"programme":8,"title":1099,"piName":10,"institution":1009,"country":280,"year":13,"amount":21,"abstract":1100},"cordis-european-research-council-award-786344","Discovering microbiome-based disease risk factors","Identifying risk factors for diseases that can be prevented or delayed by early intervention is of major importance, and numerous genetic, lifestyle, anthropometric and clinical risk factors were found for many different diseases. Another source of potentially pertinent disease risk factors is the human microbiome - the collective genome of trillions of bacteria, viruses, fungi, and parasites that reside in the human gut. However, very few microbiome disease markers were found to date.Here, we a",200,{"programme":8,"total":1103,"withPiName":1104,"firstYear":1105,"lastYear":1106,"countryCount":1107,"perYear":1108,"topInstitutions":1165,"topCountries":1236},4756,450,2008,2027,46,[1109,1111,1114,1117,1120,1123,1126,1129,1132,1135,1137,1140,1142,1145,1148,1151,1154,1157,1160,1163],{"year":1105,"count":1110},47,{"year":1112,"count":1113},2009,232,{"year":1115,"count":1116},2010,248,{"year":1118,"count":1119},2011,276,{"year":1121,"count":1122},2012,293,{"year":1124,"count":1125},2013,344,{"year":1127,"count":1128},2014,359,{"year":1130,"count":1131},2015,138,{"year":1133,"count":1134},2016,299,{"year":1136,"count":1113},2017,{"year":1138,"count":1139},2018,376,{"year":13,"count":1141},241,{"year":1143,"count":1144},2020,137,{"year":1146,"count":1147},2021,228,{"year":1149,"count":1150},2022,322,{"year":1152,"count":1153},2023,252,{"year":1155,"count":1156},2024,243,{"year":1158,"count":1159},2025,222,{"year":1161,"count":1162},2026,264,{"year":1106,"count":1164},3,[1166,1169,1172,1175,1178,1181,1184,1187,1190,1193,1196,1199,1202,1205,1208,1211,1214,1217,1219,1222,1224,1226,1228,1231,1233],{"name":1167,"count":1168},"Centre National de la Recherche Scientifique CNRS",206,{"name":1170,"count":1171},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",133,{"name":1173,"count":1174},"University of Oxford",128,{"name":1176,"count":1177},"University of Cambridge",124,{"name":1179,"count":1180},"Eidgenoessische Technische Hochschule Zuerich",84,{"name":1182,"count":1183},"Weizmann Institute of Science",74,{"name":1185,"count":1186},"École Polytechnique Fédérale de Lausanne",72,{"name":1188,"count":1189},"University College London",69,{"name":1191,"count":1192},"Ludwig-Maximilians-Universitaet Muenchen",59,{"name":1194,"count":1195},"The Hebrew University of Jerusalem",57,{"name":1197,"count":1198},"Katholieke Universiteit Leuven",52,{"name":1200,"count":1201},"University of Bristol",49,{"name":1203,"count":1204},"University of Edinburgh",48,{"name":1206,"count":1207},"Kobenhavns Universitet",40,{"name":1209,"count":1210},"Universiteit van Amsterdam",39,{"name":1212,"count":1213},"Institut National de la Sante Et de la Recherche Medicale",38,{"name":1215,"count":1216},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",35,{"name":1218,"count":1216},"Tel Aviv University",{"name":1220,"count":1221},"Imperial College of Science Technology and Medicine",33,{"name":1223,"count":1221},"Technische Universitaet Muenchen",{"name":1225,"count":1221},"Universitat Wien",{"name":1227,"count":1221},"University of Manchester",{"name":1229,"count":1230},"Helsingin Yliopisto",32,{"name":1232,"count":1230},"Karolinska Institutet",{"name":1234,"count":1235},"Technische Universiteit Delft",30,[1237,1239,1241,1243,1245,1247,1249,1251,1253,1255,1257,1258,1260,1263,1265,1267,1269,1270,1273,1275,1278,1281,1284,1286,1289],{"name":108,"count":1238},802,{"name":27,"count":1240},778,{"name":46,"count":1242},581,{"name":168,"count":1244},390,{"name":363,"count":1246},310,{"name":20,"count":1248},302,{"name":75,"count":1250},269,{"name":280,"count":1252},202,{"name":386,"count":1254},183,{"name":319,"count":1256},153,{"name":262,"count":1256},{"name":12,"count":1259},107,{"name":1261,"count":1262},"GB",78,{"name":338,"count":1264},76,{"name":675,"count":1266},65,{"name":227,"count":1268},42,{"name":735,"count":1207},{"name":1271,"count":1272},"HU",25,{"name":305,"count":1274},24,{"name":1276,"count":1277},"US",20,{"name":1279,"count":1280},"PL",18,{"name":1282,"count":1283},"CZ",15,{"name":1285,"count":1283},"SI",{"name":1287,"count":1288},"CN",9,{"name":793,"count":1290},8]