[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-advanced-grant-2021":3,"awarded-stats-erc-advanced-grant":1111},{"awarded":4,"total":1110},[5,16,23,30,37,43,49,54,60,66,71,76,81,86,91,97,102,108,113,118,124,129,134,141,148,153,158,164,169,175,181,186,192,199,205,210,216,223,229,234,241,247,253,260,266,272,277,282,288,294,300,306,312,318,324,330,336,340,345,351,357,361,366,372,378,384,389,396,402,408,413,418,424,429,435,441,446,451,456,462,467,473,479,485,490,496,500,506,510,515,520,526,531,536,541,547,552,558,563,569,575,580,585,590,596,601,606,612,618,623,628,632,638,643,649,654,660,665,671,677,683,689,694,699,705,711,716,723,729,733,738,743,749,755,761,766,773,779,784,789,795,800,804,809,814,819,825,831,837,842,847,853,858,864,869,874,880,885,889,894,900,906,913,919,925,930,934,938,943,947,953,958,964,969,974,979,984,990,996,1001,1006,1012,1017,1022,1028,1033,1038,1043,1048,1053,1059,1064,1070,1074,1079,1084,1089,1094,1099,1104],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-885222","European Research Council","ERC Advanced Grant","The Greek philosophical schools  according to Europe’s earliest ‘history of philosophy’: Towards a new pioneering critical edition of Philodemus’ Arrangement of the Philosophers",null,"UNIVERSITA DI PISA","IT",2021,"€2,498,356","Our knowledge about Greek philosophical schools is mostly second-hand and based on Diogenes Laërtius’ 'Lives of Eminent Philosophers' (3rd century AD) and Philodemus of Gadara’s 'Arrangement of the Philosophers' (75-50 BC) – hereinafter 'Syntaxis' –, an extensive treatise in several books which represents the earliest ‘history of philosophy’ to have reached us directly from antiquity. From this work exclusively preserved by the Herculaneum papyri we may derive a virtually systematic account of t",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":20,"year":13,"amount":21,"abstract":22},"cordis-european-research-council-award-101019515","Multiscale mechanical signaling in plants","INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT","FR","€2,176,170","During development, living organisms change shape and thus also change structure. The resulting pattern of force controls cell behavior and thus development. However, the molecular mechanoperception mechanisms involved are only partially understood and how organs integrate local and global patterns of forces is another open question. Plants are ideal systems to study the multicellular implications of mechanotransduction in development because their mechanics is mainly mediated by the cell wall a",{"id":24,"funder":7,"programme":8,"title":25,"piName":10,"institution":26,"country":27,"year":13,"amount":28,"abstract":29},"cordis-european-research-council-award-885531","Evolution of the Non-Uniformitarian Earth","UNIVERSITY OF BRISTOL","UK","€3,495,978","The project will use a set of innovative techniques to study the two major events that precede classical, uniformitarian geology. We will search for crystallised remnants of the primordial terrestrial magma ocean and examine the consequences of our observations for mantle dynamics. Crystallisation of the dominant lower mantle phase, bridgmanite, imparts a Mg and Si isotopic fingerprint to cumulates and evolving liquid of the magma ocean. Identifying the relicts of these small but distinctive fra",{"id":31,"funder":7,"programme":8,"title":32,"piName":10,"institution":33,"country":34,"year":13,"amount":35,"abstract":36},"cordis-european-research-council-award-884679","SIMULACRON: From Camera Observations  to Physical Simulations of the 3D World","TECHNISCHE UNIVERSITAET MUENCHEN","DE","€3,500,000","Despite their amazing success, we believe that computer vision algorithms have only scratched the surface in terms of understanding our world from images. While most research on 3D reconstruction has been concerned with recovering the surface geometry and reflectance, SIMULACRON is focused on inferring the underlying physics (masses, elasticity, momenta, forces, etc.) and a simulation of the observed action directly from videos.  This not only provides a more profound understanding of the observ",{"id":38,"funder":7,"programme":8,"title":39,"piName":10,"institution":40,"country":41,"year":13,"amount":10,"abstract":42},"cordis-european-research-council-award-884928","Light-operated logic circuits from photonic soft-matter","INSTITUT JOZEF STEFAN","SI","I propose a revolutionary photonic technology based on self-assembled soft matter that is likely to evolve into currently unforeseen, futuristic technologies. The liquid nature and responsiveness of soft matter delivers the spontaneous self-assembly of tuneable liquid micro-lasers, liquid micro-fibres, liquid light switches, and tuneable optical micro-resonators with extremely smooth interfaces, low optical losses, elastic deformability and self-healing, all of which are difficult to obtain with",{"id":44,"funder":7,"programme":8,"title":45,"piName":10,"institution":46,"country":12,"year":13,"amount":47,"abstract":48},"cordis-european-research-council-award-101019891","Sexual dimorphIsM in renal PrOgenitors to explain gender- Specificity In kidney physiOlogy aNd diseases","UNIVERSITA DEGLI STUDI DI FIRENZE","€2,296,900","Kidney disorders represent a major global health burden with a significant sexual dimorphism that is largely unexplained. My group first identified the stem cells of the kidney (renal progenitors) and demonstrated their crucial role in kidney disease. Here, I propose that sex hormones regulate number and function of renal progenitors to empower females to face the hemodynamic and metabolic challenges of pregnancy. I further propose that this process impacts on sexual dimorphisms in incidence and",{"id":50,"funder":7,"programme":8,"title":51,"piName":10,"institution":33,"country":34,"year":13,"amount":52,"abstract":53},"cordis-european-research-council-award-101021526","Unlocking vital mysteries in respiratory biomechanics","€2,499,160","While the human lung is undoubtedly an essential organ, and respiratory diseases are leading causes of death and disability in the world, there still exist a lot of mysteries wrt vital processes. The main reason for this is the complete lack of measurement methods or medical imaging techniques that would allow to study dynamic processes in essential parts of a living human lung. While this would be a perfect setup for computational modeling, existing models suffer from severe constraints disabli",{"id":55,"funder":7,"programme":8,"title":56,"piName":10,"institution":57,"country":34,"year":13,"amount":58,"abstract":59},"cordis-european-research-council-award-101019739","A microscopic view of fermionic quantum matter with long-range interactions","UNIVERSITY OF STUTTGART","€2,496,420","Strongly interacting Fermi gases appear in nature from the smallest to the largest scales  from atomic nuclei to white dwarfs and neutron stars. However, they are notoriously difficult to model and understand theoretically. Emulating such Fermi systems with ultracold atoms has been highly successful in recent years, but the approach has been limited to short-range interactions of the van der Waals type. Longer-range interactions such as dipolar or atomcharge interactions would provide a signific",{"id":61,"funder":7,"programme":8,"title":62,"piName":10,"institution":63,"country":20,"year":13,"amount":64,"abstract":65},"cordis-european-research-council-award-101019522","Molecular materials for a new generation of artificial muscles","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€2,666,152","Actuator devices converting energy into motion are a fundamental part of everyday life. However, there is currently an unmet need in actuation technologies to provide soft, smooth, noiseless movement that can mimic human motion and dexterity. The development of such “artificial muscles” is burgeoning in both interest and importance as it would enable significant advances in areas as important as robotics, medicine and aeronautics. To enable a step-change in this field, E·MOTION proposes to devel",{"id":67,"funder":7,"programme":8,"title":68,"piName":10,"institution":63,"country":20,"year":13,"amount":69,"abstract":70},"cordis-european-research-council-award-101018181","Challenging the Standard Model with the scrutiny of b to qll transitions","€2,221,993","Today, Particle Physics is in an unusual situation with a theory, the Standard Model (SM), able to accurately describe a very large number of precise measurements but at the cost of ad hoc features in the fermionic sector. Furthermore, the SM is unable to answer key questions raised by cosmological observations. Consequently, the ball is now on experiment side to search for signs of non-SM physics (NP). The most straightforward way to hunt for NP particles is to seek for their signatures directl",{"id":72,"funder":7,"programme":8,"title":73,"piName":10,"institution":63,"country":20,"year":13,"amount":74,"abstract":75},"cordis-european-research-council-award-884715","Nuclear rEaCTions At storage Rings","€2,500,000","Obtaining reliable cross sections for neutron-induced reactions on unstable nuclei is a highly important task and a major challenge. These data are essential for nuclear astrophysics -since most of the heavy elements in the Universe are produced by neutron-induced reactions in stars- and for applications in nuclear technology. However, their measurement is very complicated as both projectile and target are radioactive. The most promising way to infer these cross sections is to use surrogate reac",{"id":77,"funder":7,"programme":8,"title":78,"piName":10,"institution":63,"country":20,"year":13,"amount":79,"abstract":80},"cordis-european-research-council-award-101019963","GENome and Epigenome integrity Consecutive to  DSBs in Active REgion","€1,754,552","DNA double-strand breaks (DSBs) are toxic lesions, holding the potential to generate mutations, copy number alterations and translocations. Beyond programmed DSBs induced during meiosis and antibody repertoire generation, DSBs were historically seen as rare, mostly therapy-induced DNA lesions. However, recent work unequivocally revealed that endogenous DSBs occur far more frequently that initially believed, including in physiological conditions, such as neuron stimulation, and mainly fall within",{"id":82,"funder":7,"programme":8,"title":83,"piName":10,"institution":63,"country":20,"year":13,"amount":84,"abstract":85},"cordis-european-research-council-award-101020985","The Philosophy of Leibniz in the Light of his Unpublished Mathematical Manuscripts","€2,499,477","Gottfried Wilhelm Leibniz (1646-1716) is one of the most prominent philosophers and mathematicians of Early Modern times. As he himself emphasized on various occasions, these two facets of his work were closely related. Yet, half of his mathematical production is still completely unknown – a dramatic situation which has no equivalent for other great thinkers from that period. Moreover, about half of what has been published appears to have been established without adhering to rigorous scientific ",{"id":87,"funder":7,"programme":8,"title":88,"piName":10,"institution":63,"country":20,"year":13,"amount":89,"abstract":90},"cordis-european-research-council-award-101019907","Highly Accurate Molecular Properties using variational Quantum Electrodynamics","€1,929,658","Quantum chemical calculations are today in a position where they not only assist, but may also challenge experiment, at least for molecules containing light atoms only. When heavy atoms are present, achieving the same accuracy becomes more challenging, not only because of relativistic effects, but also because the larger number of electrons and the often complicated electronic structures make the electron correlation problem harder. When surveying the physics that has to be included in order to ",{"id":92,"funder":7,"programme":8,"title":93,"piName":10,"institution":94,"country":27,"year":13,"amount":95,"abstract":96},"cordis-european-research-council-award-101020068","Quantitative Models of Cities","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","€1,868,235","One of the most striking empirical regularities is the huge divergence in economic activity both across and within countries. Within countries, this is most clearly illustrated by the vast differences in economic activity between cities and rural areas. Despite this first-order economic phenomenon, the study of the economics of cities has been a niche interest for much of the 20th century. This has changed recently with the arrival of data with a high level of spatial resolution for cities and k",{"id":98,"funder":7,"programme":8,"title":99,"piName":10,"institution":100,"country":27,"year":13,"amount":74,"abstract":101},"cordis-european-research-council-award-101020934","Argumentation-based Deep Interactive EXplanations(ADIX)","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","Today’s AI landscape is permeated by plentiful data and dominated by powerful methods with the potential to impact a wide range of human sectors, including healthcare and the practice of law.  Yet,  this potential is hindered by the opacity of most data-centric AI methods and it is widely acknowledged that AI cannot fully benefit society without addressing its widespread inability to explain its outputs, causing human mistrust and doubts regarding its regulatory and ethical compliance. Extensive",{"id":103,"funder":7,"programme":8,"title":104,"piName":10,"institution":105,"country":20,"year":13,"amount":106,"abstract":107},"cordis-european-research-council-award-101021538","Greenhouse Gas and Pollutant Emission Reductions  using Plasma-Assisted Combustion for a Blue Planet","CENTRALESUPELEC","€2,497,336","To fight climate change, we must urgently reduce the CO2 emissions caused by fossil-fuel combustion, which represents today over 80% of the primary energy production. Clean electrified solutions are on the horizon but are unlikely to reach commercial development before 2040. Novel CO2-neutral (biofuels) or CO2-free (H2) combustion technologies are widely considered, but these technologies face increasingly stringent regulations on pollutant emissions, in particular nitric oxides and carbon monox",{"id":109,"funder":7,"programme":8,"title":110,"piName":10,"institution":63,"country":20,"year":13,"amount":111,"abstract":112},"cordis-european-research-council-award-101019965","Solidification of Earth's Primitive Mantle","€2,453,000","Earth’s mantle was extensively molten in its first 100 million years. Its solidification left a strong compositional and structural imprint on the mantle, still observable today in the geochemical and geophysical record. Isotopic variations in basalts and ancient crust reveal the existence of one or more mantle reservoirs that formed early in Earth’s history, and never fully remixed. Seismic tomography reveals large, chemically distinct, thermochemical structures in the lowermost mantle, anchore",{"id":114,"funder":7,"programme":8,"title":115,"piName":10,"institution":63,"country":20,"year":13,"amount":116,"abstract":117},"cordis-european-research-council-award-882673","Computational methods and modeling to decipher organelle nanophysiology","€2,374,698","Neuronal and glial physiology in nanodomains remains poorly understood due to the spatio-temporal limitation of direct unperturbed in vivo measurements. Yet, it is the scale of voltage regulation, ionic, proteins and molecular trafficking, metabolism control and local signal transduction. The goal of this proposal is to determine how the flow of ions and molecules is regulated in the cytoplasm in relation with organelles, such as the endoplasmic reticulum and mitochondria in various physiologica",{"id":119,"funder":7,"programme":8,"title":120,"piName":10,"institution":121,"country":34,"year":13,"amount":122,"abstract":123},"cordis-european-research-council-award-101019835","Understanding the mechanical control of cell extrusion in collective assemblies","FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG","€2,499,000","Epithelia are assemblies of multiple cells whose complex dynamic behavior relies on physical properties including jamming-unjamming mechanisms, active turbulence and active nematic principles. The homeostasis of epithelia is crucial to maintain barrier function and integrity while epithelial cells are constantly challenged by the environment. To face these challenges, epithelia are dynamics and have to deal constantly with cell renewal and apoptotic extrusion, whose balance is key for epithelia ",{"id":125,"funder":7,"programme":8,"title":126,"piName":10,"institution":63,"country":20,"year":13,"amount":127,"abstract":128},"cordis-european-research-council-award-101020459","Low frequency radio search and study of exoplanet magnetospheres and star-planet plasma interactions","€2,212,500","The project aims at expanding the planetology, exoplanets and space weather fields by obtaining the first confirmed detections and subsequent in-depth studies of radio emissions from exoplanets. Origin of the emissions can be the magnetosphere of the exoplanet or its plasma interaction with its parent star. Magnetospheres of Solar System planets are very diverse, although emerging from the same basic plasma physics laws. Better sampling the parameter space by exploring various stellar luminositi",{"id":130,"funder":7,"programme":8,"title":131,"piName":10,"institution":63,"country":20,"year":13,"amount":132,"abstract":133},"cordis-european-research-council-award-885145","A Multiscale Analysis of Bacterial Predation","€2,370,352","Predation arguably impacts the evolution and shape of ecological systems. This process occurs at all scales from mammals to viruses. Predatory bacteria remain poorly studied despite their biological importance and often versatile experimental tractability. In this project, we propose to remedy this gap and study the molecular, cellular and ecological aspects of a collective bacterial predatory behavior. Specifically, capitalizing from previous molecular studies on motility, we will investigate h",{"id":135,"funder":7,"programme":8,"title":136,"piName":10,"institution":137,"country":138,"year":13,"amount":139,"abstract":140},"cordis-european-research-council-award-885689","Lossless information for Emerging Information Technologies","INTERNATIONAL IBERIAN NANOTECHNOLOGY LABORATORY","PT","€2,993,625","In nanoelectronic circuits, interconnects use more energy than microprocessors, a situation clearly undesirable for e.g. autonomous Internet of Things applications based on charge and other information tokens. Overcoming this issue and minimising overall power consumption will be of paramount importance as we move towards Beyond-CMOS circuits. A novel approach is required. In LEIT I propose to investigate phonons as information carriers with typical ultralow energies of a fraction of a meV. As q",{"id":142,"funder":7,"programme":8,"title":143,"piName":10,"institution":144,"country":145,"year":13,"amount":146,"abstract":147},"cordis-european-research-council-award-884532","Detection and Speciation of Gas-Phase Atmospheric Peroxy and Criegee Radicals","KUNGLIGA TEKNISKA HOEGSKOLAN","SE","€3,419,744","Earth’s lower atmosphere is oxidative and its chemistry consists of reactions of short-lived chemical compounds called radicals, controlling the abundance of key compounds, such as of ozone and greenhouse gases. In spite of decades of investigation many atmospheric observations indicate that important aspects of this radical chemistry remain ill-understood, in particular in the reactions of the multitude of organic radicals present in the atmosphere, peroxy radicals (“RO2”) and Criegee Intermedi",{"id":149,"funder":7,"programme":8,"title":150,"piName":10,"institution":151,"country":20,"year":13,"amount":10,"abstract":152},"cordis-european-research-council-award-884988","A mechanistic approach to understand microbiome-viriome dynamics in nature","INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER","Facing the therapeutic impasse of antibiotics, farming systems, among which aquaculture, should consider the extraordinary resource of phages, the natural bacterial predators, for environmental friendly practices. It is, however, crucial to understand how phages can control pathogens in a sustainable and safety manner. The goal of this project is to shed light on key ecological and evolutionary processes underlying phage-bacteria dynamics in the marine environment. An oyster bacterial pathogen, ",{"id":154,"funder":7,"programme":8,"title":155,"piName":10,"institution":46,"country":12,"year":13,"amount":156,"abstract":157},"cordis-european-research-council-award-101019166","Humanitarianism and Mediterranean Europe: A Transnational and Comparative History (1945-1990)","€1,968,945","In recent years, international humanitarianism has increasingly attracted the interest of historians. A great deal of research has reconstructed aid programmes for those who are victims of war, natural disaster or economic disadvantage. These studies have mainly examined the experience of donor countries in northern Europe, as well as the United States, while the countries of southern Europe have largely been overlooked. HumanEuroMed challenges this unbalance. It puts the countries of Mediterran",{"id":159,"funder":7,"programme":8,"title":160,"piName":10,"institution":161,"country":162,"year":13,"amount":10,"abstract":163},"cordis-european-research-council-award-101020534","Death Receptors as Integrators of Stress-induced inflammation","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","IE","Inflammation is initiated in response to the detection of foreign entities, called PAMPs derived from infectious agents, or due to the release of intracellular contents, called DAMPs, due to serious tissue damage (i.e. necrosis). However, inflammation can also be initiated in response to Cell Stress (e.g. ER stress, cytoplasmic stress, mitochondrial stress) resulting from perturbations in normal physiology, but how cellular stress is converted to inflammatory outputs is very poorly understood. M",{"id":165,"funder":7,"programme":8,"title":166,"piName":10,"institution":161,"country":162,"year":13,"amount":167,"abstract":168},"cordis-european-research-council-award-101020824","The evolution of land plant functional traits and how they terraformed Earth","€2,498,066","TERRAFORM will mark a step-change in the investigation of biosphere impacts on the Earth system. It will integrate concepts and rich data sources from contemporary global trait ecology with novel simulated paleo-Earth weathering\u002Fdecomposition experiments and high-resolution analyses of fossil plant paleotrait data  to quantify the terrestrial biosphere’s impact on the carbon, nutrient and hydrological cycles in deep-time. The focus on extensive fossil plant archives spanning three episodes of ma",{"id":170,"funder":7,"programme":8,"title":171,"piName":10,"institution":172,"country":173,"year":13,"amount":10,"abstract":174},"cordis-european-research-council-award-884328","Inequalities in Lifespans before and after Retirement: Trailblazing Demographic Theory and Analysis","SYDDANSK UNIVERSITET","DK","How unequal are lifespans at older ages? How unequal will they be in the future? The length of life is often summarized by life expectancy, but the mean does not capture the spread. Distributions of lifespans need to be analyzed and forecast. Given the relevance of such research—for assessing pension reforms and other social and health policies—it is remarkable how little demographic modeling has been devoted to inequalities at older ages in individual lifespans. The research proposed here has t",{"id":176,"funder":7,"programme":8,"title":177,"piName":10,"institution":178,"country":179,"year":13,"amount":74,"abstract":180},"cordis-european-research-council-award-101018826","A novel control paradigm for large-scale hybrid networks","TECHNISCHE UNIVERSITEIT DELFT","NL","I will develop efficient on-line control methods for large-scale Networks with Hybrid Dynamics (NHDs) in the presence of uncertainties, where hybrid dynamics refers to a combination of continuous dynamics, mode switches, and\u002For topology changes. This topic is one of the core fundamental open problems in the field of systems and control. It is also important from a societal point of view as todays society depends heavily on the reliable and efficient operation of road, railway, electricity, gas, ",{"id":182,"funder":7,"programme":8,"title":183,"piName":10,"institution":184,"country":20,"year":13,"amount":10,"abstract":185},"cordis-european-research-council-award-885414","Scattering Amplitudes for Gravitational Wave Theory","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","Four years ago, the LIGO\u002FVirgo observation of a black-hole binary mergerheralded the dawn of gravitational-wave astronomy.  The promise of futureobservations calls for an invigorated effort to underpin the theoreticalframework and supply the predictions needed for detecting future signals andexploiting them for astronomical and astrophysical studies.  Ampl2Einsteinwill take ideas and techniques from recent years' dramatic advances in QuantumScattering Amplitudes, creating new tools for taking th",{"id":187,"funder":7,"programme":8,"title":188,"piName":10,"institution":189,"country":20,"year":13,"amount":190,"abstract":191},"cordis-european-research-council-award-101019141","Spinning Active Matter","ECOLE NORMALE SUPERIEURE DE LYON","€2,443,276","Active-matter physics describes the mesmerizing  dynamics of interacting motile bodies: from  bird flocks and cell colonies, to collections of synthetic units independently driven far from equilibrium.  Until now, however,   all man-made realizations  have been merely limited to 2D model systems. We will introduce a paradigm shift to upgrade the status of synthetic active matter from aesthetic 2D experiments  to genuine 3D materials with  unanticipated engineering applications. The essential goa",{"id":193,"funder":7,"programme":8,"title":194,"piName":10,"institution":195,"country":196,"year":13,"amount":197,"abstract":198},"cordis-european-research-council-award-883739","Engineering epithelial shape and mechanics: from synthetic morphogenesis to biohybrid devices","FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA","ES","€2,499,470","All surfaces of our body, both internal and external, are covered by thin cellular layers called epithelia. Epithelia are responsible for fundamental physiological functions such as morphogenesis, compartmentalization, filtration, transport, environmental sensing and protection against pathogens. These functions are determined by the three-dimensional (3D) shape and mechanics of epithelia. However, how mechanical processes such as deformation, growth, remodeling and flow combine to enable functi",{"id":200,"funder":7,"programme":8,"title":201,"piName":10,"institution":202,"country":20,"year":13,"amount":203,"abstract":204},"cordis-european-research-council-award-101018214","Financial Information, Data Abundance, and Investment","ETABLISSEMENT D'ENSEIGNEMENT SUPERIEUR CONSULAIRE HAUTES ETUDES COMMERCIALES DE PARIS","€1,098,700","Thierry Foucault ERC ADG 2020Recent years have witnessed a massive growth in the volume and variety of data (Data Abundance). In parallel, thanks to progress in computing power, new techniques (“Artificial Intelligence”) have emerged to harness the information in these data. How does this evolution affect the quality and nature of information produced in financial markets? Is there a risk that it induces investors to trade on noisier signals about economic fundamentals? How does it change the ho",{"id":206,"funder":7,"programme":8,"title":207,"piName":10,"institution":26,"country":27,"year":13,"amount":208,"abstract":209},"cordis-european-research-council-award-101020715","Natural nEUROactive Mechanical mETAmaterials","€2,478,140","Metamaterials with anomalous and counter-intuitive multiphysics behaviours have been developed during the last two decades to help communication systems, sensing and robotics. Paradigmatic developments in artificial intelligence, Digital Twin approaches and additive manufacturing are pushing the design and production of metamaterials also towards the development artificial equivalent of synapsis and programmability. These advanced metamaterial concepts are however fossil-based and tend to make u",{"id":211,"funder":7,"programme":8,"title":212,"piName":10,"institution":213,"country":27,"year":13,"amount":214,"abstract":215},"cordis-european-research-council-award-101019164","Music and Artificial Intelligence: Building Critical Interdisciplinary Studies","UNIVERSITY COLLEGE LONDON","€2,139,259","Recent years have seen escalating concern about the impacts of artificial intelligence (AI). While growing academic and policy literatures address the social and ethical implications of AI, as yet no major research initiative examines AI’s cultural implications. Music has long been a site of AI experimentation and commercial development in culture; yet although considerable research resources are going to scientific and artistic projects in this area, critical research on music AI – despite the ",{"id":217,"funder":7,"programme":8,"title":218,"piName":10,"institution":219,"country":220,"year":13,"amount":221,"abstract":222},"cordis-european-research-council-award-101020767","DIGIPARENT - Implementation, personalization and genetics of digitally assisted parent training intervention to improve child mental health services.","TURUN YLIOPISTO","FI","€2,499,198","Childhood disruptive behavior problems pose huge challenge to societies given the high lifetime burden and costs associated. Mounting evidence shows that parent training is the most effective psychosocial treatment for these problems. However, most parents in need of such training do not receive it. DIGIPARENT  shift the research focus from specialized care face-to-face parent training to  study  digitally assisted parent training  interventions when implemented in  primary health. The proposal ",{"id":224,"funder":7,"programme":8,"title":225,"piName":10,"institution":226,"country":179,"year":13,"amount":227,"abstract":228},"cordis-european-research-council-award-101021500","Leveraging genomic discoveries and skeletal phenotyping to improve osteoporosis patient care","ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM","€2,499,995","Osteoporosis is a silent, systemic skeletal disease leading to fragility fracture. While the deleterious consequences for the individual, their families and society are well established, the causes of the disease remain elusive. Despite exhaustive clinical, epidemiological and genomic research, scarce understanding of the complex underlying disease mechanisms leading to bone fragility has hindered the improvement of clinical care.  This LEGENDARE programme aims to implement a holistic integrativ",{"id":230,"funder":7,"programme":8,"title":231,"piName":10,"institution":232,"country":220,"year":13,"amount":10,"abstract":233},"cordis-european-research-council-award-101020762","Team semantics and dependence logic","HELSINGIN YLIOPISTO","In the traditional so-called Tarski’s Truth Definition the semantics of first order logic is defined with respect to an assignment of values to the free variables.  A richer family of semantic concepts can be modelled if semantics is defined with respect to a set (a team) of such assignments. This is what is called team semantics, a term coined by the PI in his 2007 monograph, and used ever since to describe this highly non-trivial modification of Tarskian semantics. Team semantics was introduce",{"id":235,"funder":7,"programme":8,"title":236,"piName":10,"institution":237,"country":238,"year":13,"amount":239,"abstract":240},"cordis-european-research-council-award-101021081","Circular Thermoset Materials: How to exploit Precision Engineered Macromolecules in their Bottom-up Design?","UNIVERSITEIT GENT","BE","€2,482,500","While displaying superior properties compared to thermoplastic polymers, thermosets – which have an annual global production of 40 million tons and are for example used in windmill blades and adhesives – represent a major worldwide challenge. Their crosslinked structure presents many hurdles when it comes to recycling and responding to Europe’s desire for a circular economy.The overarching objective of the CiMaC-program is to propose ground-breaking solutions to the major shortcomings of Covalen",{"id":242,"funder":7,"programme":8,"title":243,"piName":10,"institution":244,"country":27,"year":13,"amount":245,"abstract":246},"cordis-european-research-council-award-101019499","EXTRacEllular matrix MEchanochemistry: a solid-state NMR approach","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€3,498,825","The mechanical properties of structural animal tissues like bone, tendon and skin are determined by the extracellular matrix (ECM) of the tissue, a complex, changeable 3D material that forms a scaffold around the tissue’s cells.  The matrix is under constant mechanical stress from our everyday movements.  When it is damaged, cells in the tissue repair it; where there is repeated damage, cells must strengthen the matrix, not just repair. Thus, drivers of cell behaviour are encoded into the detail",{"id":248,"funder":7,"programme":8,"title":249,"piName":10,"institution":250,"country":27,"year":13,"amount":251,"abstract":252},"cordis-european-research-council-award-101020615","Music Culture in the Age of Streaming","UNIVERSITY OF LEEDS","€2,499,379","Hundreds of millions of people across the world now experience music via ‘streaming services’, which offer on-demand access, by means of internet or mobile telephony, to vast catalogues of music, either ‘free’ (advertising-supported) or via subscription. A controversial but poorly-understood new system of music production, distribution and consumption has developed around such services, yet there has been no sustained, integrated analysis of this system, the considerable international variations",{"id":254,"funder":7,"programme":8,"title":255,"piName":10,"institution":256,"country":257,"year":13,"amount":258,"abstract":259},"cordis-european-research-council-award-101020558","Mechanism, regulation and functions of genome folding through loop extrusion by cohesin-NIPBL","FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH","AT","€1,679,465","Since its discovery 150 years ago, DNA has been intensely studied. As a result, it is understood in some detail how genomic DNA is replicated, repaired and segregated, and entire genomes can be sequenced. However, how DNA is folded in chromosomes has remained a mystery. It has been proposed that this is achieved by a process called loop extrusion. This hypothesis proposes that SMC complexes, multi-subunit ATPases present in all kingdoms of life, reel genomic DNA into loops, thus bringing distant",{"id":261,"funder":7,"programme":8,"title":262,"piName":10,"institution":263,"country":34,"year":13,"amount":264,"abstract":265},"cordis-european-research-council-award-884177","Poetry in the Digital Age","UNIVERSITY OF HAMBURG","€2,497,162","Contemporary performative, musical and audiovisual poetry is opening up access to a genre that has frequently been considered abstract and elitist. Sophisticated book poetry is being enhanced by popular formats and vice versa. Poetry is also gaining new functions, creating communities characterized by physical or virtual co-presence. Popular poetry formats and online practices promote the self-staging of the poet. Poetry may also serve as a tool for political activism, the expression of opinions",{"id":267,"funder":7,"programme":8,"title":268,"piName":10,"institution":269,"country":238,"year":13,"amount":270,"abstract":271},"cordis-european-research-council-award-883033","Did elite human capital trigger the rise of the West? Insights from a new database of European scholars","UNIVERSITE CATHOLIQUE DE LOUVAIN","€1,311,263","My aim is to determine the role of elite knowledge and upper-tail human capital (UTHC) in triggering the rise of the West. I propose to build a database of a large sample of academic scholars in Europe over the period 1000CE-1800CE. Sources will be primary (published cartularia and matricula), secondary (books on the history of universities & academies), and tertiary (biographical dictionaries). To measure the quality of scholars, these data will be matched with the existing catalogues of public",{"id":273,"funder":7,"programme":8,"title":274,"piName":10,"institution":244,"country":27,"year":13,"amount":275,"abstract":276},"cordis-european-research-council-award-101019828","Engineering low power tunnel transistors based on two-dimensional semiconductors","€2,499,948","Modern electronics consume a huge amount of world’s energy – currently ~ 5% and rising to > 20% in 2030. Field effect transistors (FETs) account for a large fraction of the energy consumed in electronics due to high OFF state (leakage) currents and large operating voltage (~ 0.8V). Tunnel FETs (TFETs) based on two-dimensional semiconductors (2D SCs) provide unique and game-changing solutions for both of these problems and can be engineered using industry compatible complementary metal oxide semi",{"id":278,"funder":7,"programme":8,"title":279,"piName":10,"institution":280,"country":34,"year":13,"amount":10,"abstract":281},"cordis-european-research-council-award-101021493","Cellular basis of Artemisinin resistance in malaria parasites","BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN","Blood stages of the protozoan parasite Plasmodium falciparum are responsible for malaria, a disease that kills more than 400'000 people annually. During its development in red blood cells the parasite internalises a large part of the host cell cytosol (hemoglobin) in an endocytic process and digests it in its food vacuole. We recently identified a critical connection of this hemoglobin endocytosis with resistance of the parasite to the current frontline drug Artemisinin, revealing the mechanism ",{"id":283,"funder":7,"programme":8,"title":284,"piName":10,"institution":285,"country":34,"year":13,"amount":286,"abstract":287},"cordis-european-research-council-award-884488","Single-Molecule Metal-Induced Energy Transfer (smMIET)","GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS","€2,740,188","The core aim of the project is to develop the technology of Single-Molecule Metal-Induced Energy Transfer (smMIET) for resolving macromolecular structure and dynamics with sub-nanometre spatial resolution and nanosecond temporal resolution. Metal-Induced Energy Transfer or MIET was first developed in our group in 2012 for mapping cellular membranes with nanometre axial resolution. It exploits the effect that a fluorescent molecule, when brought close to a metal surface, can transfer its excited ",{"id":289,"funder":7,"programme":8,"title":290,"piName":10,"institution":291,"country":257,"year":13,"amount":292,"abstract":293},"cordis-european-research-council-award-101020331","Random matrices beyond Wigner-Dyson-Mehta","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","€1,912,439","Random matrix theory (RMT) was created in the 1950's by the pioneering idea of E. Wigner predicting that the distribution of the gaps between energy levels of complex quantum systems is universal in the sense that it is independent of the physical details of the model apart from its basic symmetry type. He proposed to study eigenvalues of large matrices with random entries as the fundamental model for his new universal statistics, later coined Wigner-Dyson-Mehta (WDM) universality. Mathematical ",{"id":295,"funder":7,"programme":8,"title":296,"piName":10,"institution":297,"country":34,"year":13,"amount":298,"abstract":299},"cordis-european-research-council-award-883759","Chiral aqueous-phase chemistry","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€2,490,250","Most chemical reactions in lifeforms take place in aqueous environments and probing biochemical molecules and their reactions in the aqueous phase is indispensable for advancing fundamental and applied science. Equally, intermolecular effects involving chiral complexes are highly relevant to life sciences, where hydration and chiral recognition are fundamental biochemical processes, typically occurring at aqueous interfaces. All of these processes are driven by electronic structure interactions ",{"id":301,"funder":7,"programme":8,"title":302,"piName":10,"institution":303,"country":34,"year":13,"amount":304,"abstract":305},"cordis-european-research-council-award-884281","Mechanisms of Presynaptic Biogenesis and Dynamic Remodeling","FORSCHUNGSVERBUND BERLIN EV","€2,496,875","Our ability to move, to process sensory information or to form, store and retrieve memories crucially depends on the function of neuronal synapses. Synapses comprise a presynaptic compartment harboring the machinery for neurotransmitter release and an associated postsynaptic compartment that processes the neurotransmitter signal. During decades of research we have acquired a wealth of knowledge regarding the mechanisms of neurotransmitter release and information processing in the postsynaptic co",{"id":307,"funder":7,"programme":8,"title":308,"piName":10,"institution":309,"country":27,"year":13,"amount":310,"abstract":311},"cordis-european-research-council-award-101020369","A Theory of Organic Bioelectronics Materials","THE UNIVERSITY OF LIVERPOOL","€2,257,300","The goal of bioelectronics is to interface electrical devices with living tissues, cells and biological fluids to achieve a range of functions: from monitoring biological activity to controlling neuron signals and administering drugs. The materials developed to build these interfaces are typically organic materials containing polymeric conjugated chains combined with ionic components in water. At the moment there is no clear structure-function theory for these materials and no microscopic unders",{"id":313,"funder":7,"programme":8,"title":314,"piName":10,"institution":315,"country":34,"year":13,"amount":316,"abstract":317},"cordis-european-research-council-award-101019191","Synaptic Promiscuity in Brain Development","FREIE UNIVERSITAET BERLIN","€2,296,912","Precise synaptic connectivity is a prerequisite for the function of neural circuits, yet individual neurons, taken out of their developmental context, readily form unspecific synapses. The goal of this proposal is to understand the roles and requirements of such promiscuous synapse formation during brain development. The observation of promiscuous synapse formation is not at odds with precise outcomes. The developmental program can ensure correct partnerships between neurons that form synapses p",{"id":319,"funder":7,"programme":8,"title":320,"piName":10,"institution":321,"country":27,"year":13,"amount":322,"abstract":323},"cordis-european-research-council-award-885069","Synaptome architecture of the single neuron","THE UNIVERSITY OF EDINBURGH","€1,738,561","Synapses participate in all our thoughts and actions and are damaged in over 100 genetic brain disorders. Synapses are the hallmark of brain complexity, being present in vast numbers and containing thousands of different proteins. Unravelling this complexity to get at the functional logic embedded within is a major challenge in neuroscience. We recently characterised excitatory synapse molecular diversity across the whole mammalian brain, revealing a remarkable 3D organisation of synapse types a",{"id":325,"funder":7,"programme":8,"title":326,"piName":10,"institution":327,"country":27,"year":13,"amount":328,"abstract":329},"cordis-european-research-council-award-101021229","Gaze and Eye Movement in Interaction","UNIVERSITY OF LANCASTER","€2,490,391","Gaze is a compelling modality for human-computer interaction (HCI). Where we look implicitly reflects our goals and information needs, and we are able to direct our gaze at will and speed across our environment, to efficiently communicate interest and express intent. However, in decades of research on gaze interfaces, the approach has been to consider eye movement in isolation and ignore concurrent movement of head and body. GEMINI will develop a fundamentally different approach, from the ground",{"id":331,"funder":7,"programme":8,"title":332,"piName":10,"institution":333,"country":179,"year":13,"amount":334,"abstract":335},"cordis-european-research-council-award-885065","Optimal Cellular Prediction","STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN","€2,496,750","The ability to respond to changes in the environment is a defining property of life. Strikingly, experiments have vividly demonstrated that even single-celled organisms can leverage correlations in the environmental fluctuations to predict the future environment and mount a response ahead of time. Yet, how reliably single cells can do so and what the fitness benefit of prediction is, are wide-open questions.To predict the future environment, cells need to compress the past signal into the dynami",{"id":337,"funder":7,"programme":8,"title":338,"piName":10,"institution":327,"country":27,"year":13,"amount":10,"abstract":339},"cordis-european-research-council-award-883621","Diversity, stability and functioning of the soil microbiome","A major challenge for advancing our understanding of the functional role of highly complex soil microbial communities is to systematically link changes in their structure and functioning to biogeochemical cycles under realistic scenarios of global change. This is a formidable challenge: not only does it require a step change in our understanding of the factors that shape soil microbial communities and their functioning, but also it requires new knowledge of the ecological and genetic mechanisms ",{"id":341,"funder":7,"programme":8,"title":342,"piName":10,"institution":121,"country":34,"year":13,"amount":343,"abstract":344},"cordis-european-research-council-award-101018634","Voxel Based Material Design: Amalgamation of Additive Manufacturing and Scanning Electron Microscopy","€2,945,003","AMELI aims to exploit the potential of the layer-by-layer approach of metal powder bed based additive manufacturing to blaze the way to a groundbreaking new design freedom in manufacturing: Voxel based material design. If successful, AMELI will solve one of the most important challenges in metal-based manufacturing of high performance components: Control and adaption of the local material properties. In order to reach this aim, AMELI will amalgamate the potential of powder bed based electron bea",{"id":346,"funder":7,"programme":8,"title":347,"piName":10,"institution":348,"country":20,"year":13,"amount":349,"abstract":350},"cordis-european-research-council-award-101018130","Bipartite Network Models for Marriage and Labour Markets","FONDATION NATIONALE DES SCIENCES POLITIQUES","€1,910,150","Research proposal MARNET aims at improving our empirical knowledge of markets structured as bipartite networks (all connections involve two different categories of agents) by providing better statistical models of network formation and the effects of the network structure on outcomes. The use of random graphs, in which an edge between two nodes is the realization of a random draw, to model networked social, technological and biological systems has been subject to a novel and vigorous effort over",{"id":352,"funder":7,"programme":8,"title":353,"piName":10,"institution":354,"country":34,"year":13,"amount":355,"abstract":356},"cordis-european-research-council-award-101019157","Gut epithelial dynamics and function at the nexus of early life infection and long-term health","UNIVERSITAETSKLINIKUM AACHEN","€2,450,000","Infections of the gastrointestinal tract and their long-term consequences remain a major cause of childhood mortality and morbidity worldwide. In addition, early life is recognized as a critical and non-redundant time period to prime the mucosal tissue and establish the enteric microbiota that determine the risk to develop prevalent inflammatory, immune-mediated, and metabolic diseases. Three factors: the enteric microbiota, the mucosal immune system and the epithelial barrier cooperate to estab",{"id":358,"funder":7,"programme":8,"title":359,"piName":10,"institution":285,"country":34,"year":13,"amount":10,"abstract":360},"cordis-european-research-council-award-101021358","Electrochemical Bond Functionalization","The impressive progress in organic chemistry during the past century has propelled this discipline to its current central position as the enabling technology in the physical and life sciences. Despite remarkable advances, our ability to assemble molecules of even moderate structural complexity remains unsatisfactory, since these syntheses continue to be inefficient, rely on a high number of reaction and purification steps, and generate undesired, often toxic waste. These features led to the gene",{"id":362,"funder":7,"programme":8,"title":363,"piName":10,"institution":26,"country":27,"year":13,"amount":364,"abstract":365},"cordis-european-research-council-award-101021566","Conception by artificial reproductive technologies and offspring health","€2,499,951","Infertility affects 1 in 6 couples. With increasing numbers of artificial reproductive technology (ART) conceptions, understanding the effects of ART on maternal and offspring health has been designated a major research priority. Research to date has been highlighted as having limited quality and lacking methodological transparency. In ART-HEALTH we use a robust, systematic approach of triangulating different sources of evidence to address this.work-package (WP) 1 will generate three new dataset",{"id":367,"funder":7,"programme":8,"title":368,"piName":10,"institution":369,"country":179,"year":13,"amount":370,"abstract":371},"cordis-european-research-council-award-101020082","Climate change and Fossil Fuels","UNIVERSITEIT VAN AMSTERDAM","€2,499,192","To halt climate change, the 2015 Paris Agreement implicitly requires leaving fossil fuels (FF) underground (LFFU) and coherent financial flows. This implies stranding huge amounts of FF resources and assets (worth $16-300 trillion), affecting big investors: FF firms, shareholders (pension funds\u002Fphilanthropies), debt financers (aid agencies\u002Fdevelopment banks) and governments. Research is scarce on big investors, the implications for developing countries with FF resources, and how LFFU can be equi",{"id":373,"funder":7,"programme":8,"title":374,"piName":10,"institution":375,"country":20,"year":13,"amount":376,"abstract":377},"cordis-european-research-council-award-101019653","Interferometric Survey of Stellar Parameters","OBSERVATOIRE DE LA COTE D'AZUR (OCA)","€2,692,447","Fundamental stellar parameters are the primary data required for an in-depth understanding of stars, their interiors, and their environments. With the progress of stellar physics and the prospects of ground facilities or space missions, it is critical to improve the accuracy, and quantity of such data. The development of exoplanet and asteroseismology domains is demanding direct data to eliminate any bias in the parameters. And finally, the differences between methods for determining the Hubble ",{"id":379,"funder":7,"programme":8,"title":380,"piName":10,"institution":381,"country":257,"year":13,"amount":382,"abstract":383},"cordis-european-research-council-award-101019039","Topological interactions as functional regulators of the eukaryotic genome: moving beyond intramolecular looping","INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH","€2,792,500","Topological interactions between distant DNA segments play fundamental roles in the function of eukaryotic genomes. While tremendous progress has been made in understanding the molecular mechanisms shaping intramolecular chromosome loop structures, limitations in our ability to distinguish specific chromosome conformations between paired molecules has hindered research into the role of interactions across separate chromosomal DNA molecules. Our recent development of an approach allowing analysis",{"id":385,"funder":7,"programme":8,"title":386,"piName":10,"institution":387,"country":220,"year":13,"amount":74,"abstract":388},"cordis-european-research-council-award-884382","Next Generation Gene Therapy for the Treatment of Chronic Myocardial Ischemia and Heart Failure","ITA-SUOMEN YLIOPISTO","BACKGROUND: Therapeutic angiogenesis has great potential for the treatment of severe heart diseases. However, this requires novel approaches and development of new technology.ADVANCING STATE-OF-THE-ART: We will develop novel VEGF-B and VEGF-C-based gene therapy to treat refractory angina and heart failure (HF). VEGF-B and VEGF-C lead factors were selected from extensive pig studies where they showed the best benefits among all VEGFs, such as relative cardiac specificity, potent angiogenic and me",{"id":390,"funder":7,"programme":8,"title":391,"piName":10,"institution":392,"country":393,"year":13,"amount":394,"abstract":395},"cordis-european-research-council-award-882424","High-Dimensional single cell mapping of inflammatory disease signatures in monozygotic twins","UNIVERSITAT ZURICH","CH","€2,492,221","Multiple Sclerosis (MS) is a chronic inflammatory disease, where immune cell invasion into the central nervous system causes immunopathology and neurological deficit. Although disease-modifying therapies dramatically reduce disease activity, they hold the potential for severe adverse effects while long-term disability prospects remain poor. Moreover, there is to date no biomarker for monitoring the disease activity and to guide therapy decisions. I propose that the key to identifying such biomar",{"id":397,"funder":7,"programme":8,"title":398,"piName":10,"institution":399,"country":393,"year":13,"amount":400,"abstract":401},"cordis-european-research-council-award-883877","Targeting the essentialome of radiotherapy-resistant cancer","UNIVERSITAET BERN","€2,499,875","More than 50% of the cancer patients undergo irradiation as part of their cancer treatment. Although radiotherapy (RT) significantly contributes to cancer cure, local therapy resistance and the subsequent emergence of distant metastasis remain major obstacles for its success. The molecular mechanisms underlying tumor cell-intrinsic RT resistance are ill-defined. It is therefore crucial to better define these mechanisms and identify new vulnerabilities of RT-resistant tumors in order to decrease ",{"id":403,"funder":7,"programme":8,"title":404,"piName":10,"institution":405,"country":34,"year":13,"amount":406,"abstract":407},"cordis-european-research-council-award-101019280","Diadenosine Polyphosphate Alarmones as Drivers for Protein AMPylation","UNIVERSITAT KONSTANZ","€2,491,235","It is puzzling that the human genome has only slightly more genes than the fruit fly and only half the number of cauliflower. Obviously, the sheer number of genes alone cannot determine the complexity of human development and the sophisticated signalling systems that maintain homeostasis. In fact, the complexity of information from genome to proteome is greatly increased. Drivers for the complexity of the proteome are posttranslational modifications (PTMs), i.e. covalent modifications of polypep",{"id":409,"funder":7,"programme":8,"title":410,"piName":10,"institution":144,"country":145,"year":13,"amount":411,"abstract":412},"cordis-european-research-council-award-101021019","Tissue-wide identification of genome alterations in cancer","€2,631,250","We aim to develop the first generation of spatially resolved DNA methodologies to uncover the underlaying molecular landscape of cancer genomes in tissues. Our efforts will focus on a novel genome-wide technology to study genomic integrity in its spatial context, currently a major challenge in the field. The research program is based on developing new experimental protocols and new computational analysis methods. We aim to demonstrate the utility of the method in cancer applications focusing on ",{"id":414,"funder":7,"programme":8,"title":415,"piName":10,"institution":416,"country":196,"year":13,"amount":74,"abstract":417},"cordis-european-research-council-award-885323","Engineering Carbon Nanodots for (Nano)Technological and Biomedical Applications","ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE","e-DOTS takes advantage of nanoscale and process-intensification principles, information technology and automation\u002Frobotics to translate molecular properties to nanoparticles for use in technologically advanced challenges, ranging from high-quality bioimaging to green catalysis in water. A stringent molecular control over the synthesis and multivalent properties of “carbon nanodots”, 2-5 nm spherical nanoparticles, will allow us to shape a nanofabrication space with engineered functions. The core",{"id":419,"funder":7,"programme":8,"title":420,"piName":10,"institution":421,"country":27,"year":13,"amount":422,"abstract":423},"cordis-european-research-council-award-101018670","Pinpointing novel molecular and cellular functions generated by retroelement onco-exaptation","THE FRANCIS CRICK INSTITUTE LIMITED","€2,483,691","Exaptation, the co-option of endogenous retroelements (EREs) for new molecular and cellular functions that confer a host fitness advantage, is a major force in evolution, but may also be exploited, through onco-exaptation, by tumour cells to promote the oncogenic process. There are over 4 million well-recognised and annotated individual ERE integrations in the human genome. However, their participation at the level of the more complex transcriptome is far less well understood and, therefore, the",{"id":425,"funder":7,"programme":8,"title":426,"piName":10,"institution":213,"country":27,"year":13,"amount":427,"abstract":428},"cordis-european-research-council-award-884839","Anthropologies of Extortion","€2,495,250","Extortion had come to occupy a quintessential position in the global imaginary of mafia-type-criminal organizations. Yet it is also increasingly present beyond clandestine criminal networks and is becoming a normalised profitable source of livelihood and governance and a key visible social relation in many parts of the world. Systematic research on and explanatory models for the apparent expansion and rountinisation of extortion in everyday life (including cyber-extortion) are currently lacking.",{"id":430,"funder":7,"programme":8,"title":431,"piName":10,"institution":432,"country":27,"year":13,"amount":433,"abstract":434},"cordis-european-research-council-award-101021262","Textuality and Diversity: A Literary History of Europe and its Global Connections, 1545-1659","QUEEN MARY UNIVERSITY OF LONDON","€2,156,247","This five-year programme of investigation of 52 textual corpora includes Mesoamerican codices, Jesuit neo-Latin plays, popular songs, Kongolese documents in Portuguese, Cervantes’ works, examples of live speech from archives, and many others. It will produce an interdisciplinary literary history of Europe and its global connections for the period between the mid-sixteenth and mid-seventeenth centuries. The Reformation had fragmented Christendom into differing religious identities. Europeans were",{"id":436,"funder":7,"programme":8,"title":437,"piName":10,"institution":438,"country":27,"year":13,"amount":439,"abstract":440},"cordis-european-research-council-award-101019016","Choosing Islamic Conservatism:  Muslim Youth in Europe and the UK and the Question of Social Cohesion","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€2,455,847","The Islamic networks that historically embedded themselves in Muslim communities within Europe and the UK represent, in theological and methodological terms, most conservative Islamic knowledge traditions, which promote highly conservative social norms, encourage isolation from mainstream society, and in extreme cases also endorse jihad. Despite facing serious competition in recent years from Islamic scholars and institutions that are actively trying to promote teachings from the classical Islam",{"id":442,"funder":7,"programme":8,"title":443,"piName":10,"institution":438,"country":27,"year":13,"amount":444,"abstract":445},"cordis-european-research-council-award-883810","Combinatorial Applications of Random Processes and Expansion","€2,499,010","The concepts of Randomness and Expansion are pervasive throughout Mathematics and its applications to many areas of Science and Engineering. The mathematical study of Expansion can be traced back to the ancient Greeks and of Probability to the analysis (e.g. by Fermat and Pascal) of games of chance. In the modern era, both concepts are influential in many areas of Mathematics (this proposal will emphasise Combinatorics and Probability, and also touch on Analysis, Geometry, Topology, Number Theor",{"id":447,"funder":7,"programme":8,"title":448,"piName":10,"institution":348,"country":20,"year":13,"amount":449,"abstract":450},"cordis-european-research-council-award-101020598","Production, Trade and Governance: a New Framework for the Understanding of Organized Crime","€2,492,911","There is a consensus that organized crime (OC) is harmful and its profits are immense. Yet the concept of OC itself lumps together people engaging in very different activities—from peasants in Colombia to professional enablers in London to mafias in Italy—, and the data used by scholars are generally of poor quality. We are in urgent need to establish this field of study on solid analytical grounds and to produce good data. CRIMGOV is designed to do precisely that. We first present a framework t",{"id":452,"funder":7,"programme":8,"title":453,"piName":10,"institution":438,"country":27,"year":13,"amount":454,"abstract":455},"cordis-european-research-council-award-883758","Global Correspondent Banking 1870-2000","€2,408,114","The overall objective of GloCoBank is to analyse the changing shape of international banking networks across the 20th century using an innovative methodology that allows greater specificity and inclusion than ever before. The bilateral correspondent banking network that will be uncovered by GloCoBank was the structure on which the global financial system was built and on which the trade and specialization that drove global development was based, but we know very little about it. When merchants s",{"id":457,"funder":7,"programme":8,"title":458,"piName":10,"institution":459,"country":145,"year":13,"amount":460,"abstract":461},"cordis-european-research-council-award-101019613","Tracking our ancestors across the Devonian world: a new multidisciplinary approach to the origin of tetrapods","UPPSALA UNIVERSITET","€2,450,143","The origin of tetrapods (land vertebrates) during the Devonian period, a key event for the terrestrial ecosystem, is illuminated by splendid fossil discoveries but very ill-served by the dominant theoretical framework. This framework has two weaknesses: the persistence of a simplistic evolutionary scenario that has already been falsified, and a failure to properly consider the place of tetrapods in the developing terrestrial ecosystem. The scenario envisages tetrapods evolving from ‘elpistostegi",{"id":463,"funder":7,"programme":8,"title":464,"piName":10,"institution":465,"country":393,"year":13,"amount":74,"abstract":466},"cordis-european-research-council-award-883077","Novel Symbioses","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","The introduction of new functionalities into cells is a challenge, but it offers tremendous opportunities. While some traits may be acquired through lateral gene transfer and be immediately operational, others are complex and require comprehensive rewiring of the host cell due to lack of orthogonality. A powerful strategy used by cells to acquire new properties is the incorporation of other dedicated cells as endosymbionts that may eventually become organelles in the course of evolution, the mos",{"id":468,"funder":7,"programme":8,"title":469,"piName":10,"institution":470,"country":34,"year":13,"amount":471,"abstract":472},"cordis-european-research-council-award-101020842","Exploring the Universe through Strong Interactions","TECHNISCHE UNIVERSITAT DARMSTADT","€2,252,375","The ERC project EUSTRONG will enable major breakthroughs in understanding strong interactions in nuclei and neutron stars, and where strong interactions are essential in dark matter direct detection and neutrino physics. Recently, great progress has been made in constraining the nuclear equation of state from nuclear physics combined with neutron star observations and the neutron star merger GW170817. At the same time, ab initio calculations of nuclei using chiral effective field theory (EFT) in",{"id":474,"funder":7,"programme":8,"title":475,"piName":10,"institution":476,"country":196,"year":13,"amount":477,"abstract":478},"cordis-european-research-council-award-883742","Determining in vivo protein structures and understanding genetic interactions using deep mutagenesis","FUNDACIO CENTRE DE REGULACIO GENOMICA","€2,333,279","The goal of my research is to understand mutations and how they interact to alter phenotypes and disease. We recently initiated a new research direction that uses systematic (‘deep’) mutagenesis to quantify, understand, and predict how diverse mutations interact non-additively within and between molecules to affect phenotypes at multiple scales. Very excitingly, we have also shown that quantifying genetic interactions by deep mutagenesis provides sufficient information to determine the 3D struct",{"id":480,"funder":7,"programme":8,"title":481,"piName":10,"institution":482,"country":220,"year":13,"amount":483,"abstract":484},"cordis-european-research-council-award-101020977","Foundations of Perception Engineering","OULUN YLIOPISTO","€2,496,578","Virtual reality (VR) technology has enormous potential to transform society, especially as the world faces unprecedented challenges of remote work and social distancing brought on by COVID 19. Through telepresence it uniquely enhanced health care, collaborative design, education, and social interaction, all from a distance. Further benefits arise by incorporating synthetic models, which advance computer interfaces, data visualization, and immersive storytelling.In spite of its potential, the VR ",{"id":486,"funder":7,"programme":8,"title":487,"piName":10,"institution":244,"country":27,"year":13,"amount":488,"abstract":489},"cordis-european-research-council-award-101021480","Reverse engineering collective action: complex technologies in stateless societies","€2,484,690","Cooperation is a markedly human mix of innate and learned behaviour, and a key to tackling some of our greatest concerns. Paradoxically, studies of social dynamics often focus on hierarchies, state formation and political structures ruled by coercive power, with comparatively little regard to the mechanisms whereby humans voluntarily collaborate. Encouragingly, new research on collective action is reconciling classic anthropology with game theory and empirical studies of group resource managemen",{"id":491,"funder":7,"programme":8,"title":492,"piName":10,"institution":493,"country":34,"year":13,"amount":494,"abstract":495},"cordis-european-research-council-award-884235","Tackling Multi-Host Pathogenicity of Xylella by Assisted Immunity","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€2,499,260","This project addresses a complex problem in agriculture and will identify the process of multi-host pathogenicity.Emerging and re-emerging disease epidemics represent ongoing challenges to cultivation of crop plants, a global threat to food security and social stability. One of the recent disease epidemics is caused by Xylella fastidiosa, a generalist bacterium that infects a broad range of hosts, now spreading in Europe and threatening olive production. How pathogens colonize in multiple, genet",{"id":497,"funder":7,"programme":8,"title":498,"piName":10,"institution":315,"country":34,"year":13,"amount":10,"abstract":499},"cordis-european-research-council-award-885478","Ancient Astral Science in Transformation","The introduction of the zodiac in Babylonia in the 5th century BCE was a turning point in the history of astral science - astronomy and astrology, scholarship and culture at large. The zodiacal turn was accompanied by a mathematical turn in astronomy and a personal turn in astrology. From Babylonia, zodiacal astral science spread to Egypt, the Greco-Roman world and beyond. In view of its entanglement with social practices, religious doctrines, philosophical theories and iconographic expressions,",{"id":501,"funder":7,"programme":8,"title":502,"piName":10,"institution":503,"country":12,"year":13,"amount":504,"abstract":505},"cordis-european-research-council-award-101019289","Custom-designed gene editing of induced epidermal stem cells for gene therapy of genetic diseases of squamous epithelia","UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA","€2,462,375","Holo-GT will define innovative ex vivo gene therapy of dominant genetic skin disease, by using Epidermolysis Bullosa (EB) as a model system. EB is a group of dominantly or recessively inherited, devastating, incurable diseases marked by structural fragility of the integuments. The applicant has shown that combined ex vivo cell and gene therapy can cure the skin of recessive LAMB3-Junctional EB. This lifesaving procedure unveiled that the human epidermis is sustained solely by long-lived stem cel",{"id":507,"funder":7,"programme":8,"title":508,"piName":10,"institution":493,"country":34,"year":13,"amount":10,"abstract":509},"cordis-european-research-council-award-882679","Cosmological magnetic fields and plasma physics in extended structures","The majority of the visible, ordinary matter within the universe (baryons in form of hot plasma within galaxies and galaxy clusters) is shaped by complex, physical processes, which are still plagued by many enigmas (microscopic plasma instabilities; large scale progression of astrophysical systems). The available computational resources now opened the decade of their direct, numerical modelling. However, the treatment of magnetic fields and relativistic particles (so called cosmic rays) is still",{"id":511,"funder":7,"programme":8,"title":512,"piName":10,"institution":291,"country":257,"year":13,"amount":513,"abstract":514},"cordis-european-research-council-award-101020697","Structure and mechanism of respiratory chain molecular machines","€1,781,133","Eukaryotic life is made possible by energy production in mitochondria, where several large membrane protein complexes of the respiratory chain work in series to produce ATP. The structure and function of these complexes have been intensively studied over decades, but the mechanistic understanding is lacking due to their elaborate architecture. This proposal’s goal is to reveal the mechanism of energy transduction by the least understood of them: complex I, respiratory supercomplexes and transhyd",{"id":516,"funder":7,"programme":8,"title":517,"piName":10,"institution":518,"country":238,"year":13,"amount":74,"abstract":519},"cordis-european-research-council-award-101019982","Autonomous Creation of Analog Integrated Circuits based on Self-Learning of Design Expertise","KATHOLIEKE UNIVERSITEIT LEUVEN","Progress in semiconductor technology and in intelligent data processing are converging today, opening the door to countless smart ICT applications through the Cloud and Internet of Everything, to the peoples benefit in years to come. Applications that interact with the physical world (e.g. environmental sensing, healthcare, autonomous vehicles, etc.), also need analog integrated circuits in the cyber-physical or edge layer. But while digital circuits are largely synthesized automatically through",{"id":521,"funder":7,"programme":8,"title":522,"piName":10,"institution":523,"country":173,"year":13,"amount":524,"abstract":525},"cordis-european-research-council-award-101021024","Understanding the Effect of Non-natural Fluid Environments on Enzyme Stability","DANMARKS TEKNISKE UNIVERSITET","€2,352,846","Enzymes are the protein-based catalysts found throughout nature and are of immense scientific importance, and of great practical value in medicine, chemistry and biotechnology. In most practical applications (such as industrial biocatalysis), enzymes are exposed to non-natural conditions, resulting in a loss of stability. Our understanding of what leads to a loss in enzyme stability under these conditions is very poor and therefore the aim of this project is to obtain such understanding. Current",{"id":527,"funder":7,"programme":8,"title":528,"piName":10,"institution":244,"country":27,"year":13,"amount":529,"abstract":530},"cordis-european-research-council-award-101018897","Exploring the Cosmos with the Vera Rubin Observatory","€2,498,565","The standard model of cosmology postulates ingredients that are not present in the standard model of particle physics – dark matter, dark energy, and a primordial origin for cosmic structure. Their physical nature remains a mystery. In the past few years, it has become clear that formidable modelling and data analysis challenges stand in the way of establishing how these ingredients fit into fundamental physics. Starting in 2023, we have an opportunity to uncover the physical underpinning of the",{"id":532,"funder":7,"programme":8,"title":533,"piName":10,"institution":26,"country":27,"year":13,"amount":534,"abstract":535},"cordis-european-research-council-award-101021085","Fundamental Limits of Quantum Mechanics and Physical Laws in a Non-deterministic World","€2,223,065","Quantum mechanics is fundamentally different from all that came before in almost every aspect. But, as far as I can see now, there is one property that stands above all when we try to understand what quantum mechanics is all about: quantum mechanics is our first theory of Nature that is non-deterministic at a fundamental level. Long considered an unpleasant aspect, non-determinism is anything but: Non-determinism enables new freedoms. Phenomena that could not occur in deterministic theories beca",{"id":537,"funder":7,"programme":8,"title":538,"piName":10,"institution":232,"country":220,"year":13,"amount":539,"abstract":540},"cordis-european-research-council-award-101019329","Social inequalities in population health: integrating evidence from longitudinal, family-based and genetically informed data","€2,499,422","Social inequalities in health are observed in all societies. These inequalities have grown markedly over the past 30 years, with those in less advantaged social positions currently expected to live 5–10 years less than those in more advantaged positions. The study aims to establish the root causes of these inequalities by (1) assessing the drivers of long-term changes in health inequalities and establishing the contribution of family factors and macro-level social and economic conditions to thes",{"id":542,"funder":7,"programme":8,"title":543,"piName":10,"institution":544,"country":34,"year":13,"amount":545,"abstract":546},"cordis-european-research-council-award-882727","Modelling non-stationary tree growth responses to global warming","JOHANNES GUTENBERG-UNIVERSITAT MAINZ","€2,497,500","Tree-rings are a key proxy archive for reconstructing high resolution climate variability over the past 1-2ka at regional to global scales. Skillful reconstructions require a stationary relationship between tree growth and climate (Huttons principle of uniformitarianism), which is commonly evaluated by statistical calibration\u002Fverification trials against instrumental measurements. This association, however, weakened during the second half of the 20th century, when tree-ring width and density chro",{"id":548,"funder":7,"programme":8,"title":549,"piName":10,"institution":550,"country":238,"year":13,"amount":10,"abstract":551},"cordis-european-research-council-award-885203","Schobers, Mutations and Stability","UNIVERSITEIT HASSELT","Mirror symmetry is a manifestation of string theory that predicts a certain symmetry between complex geometry and symplectic geometry. Mirror symmetry is justified on physical grounds but makes nonetheless strong and testable predictions about purely mathematical concepts. A celebrated example is the prediction by physicists of the number of rational curves of a given degree in a generic quintic threefold which went far beyond classical enumerative geometry.The main actor in this proposal is the",{"id":553,"funder":7,"programme":8,"title":554,"piName":10,"institution":555,"country":196,"year":13,"amount":556,"abstract":557},"cordis-european-research-council-award-101018680","Geometric Analysis and Potential Theory","UNIVERSITAT AUTONOMA DE BARCELONA","€1,476,000","This project aims to solve several long standing questions in geometric analysis by combining techniques from harmonic analysis, geometric measure theory, and free boundary problems. These questions deal with harmonic measure and caloric measure, square functions and rectifiability, and some related free boundary problems. A common feature is that their study involves multiscale methods from Littlewood-Paley theory and quantitative rectifiability. Harmonic measure is a basic tool for the solutio",{"id":559,"funder":7,"programme":8,"title":560,"piName":10,"institution":291,"country":257,"year":13,"amount":561,"abstract":562},"cordis-european-research-council-award-885707","Spectral rigidity and integrability for billiards and geodesic flows","€1,820,816","In 1911, Hermann Weyl proved the remarkable asymptotic formula describing distribution of (large) eigenvalues of the Dirichlet Laplacian in a bounded domain Ω ⊂ RdN (λ) = (2π)−d ωd Vol(Ω) λd\u002F2(1 + o(1))as λ → +∞. where N (λ) is the number of eigenvalues of the Laplacian spectrum, which are less than λ, ωd is a volume of the unit ball in Rd, Vol(Ω)  is the volume of Ω,  and the Laplace spectrum of a domain Ω is defined as the set of positive real numbers λ (with multiplicities) that satisfy the e",{"id":564,"funder":7,"programme":8,"title":565,"piName":10,"institution":566,"country":27,"year":13,"amount":567,"abstract":568},"cordis-european-research-council-award-101018608","CBASS: Life, Death and cyclic nucleotides","THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS","€1,785,866","All living things are subject to attack by viruses. Cells have evolved many different immune systems to protect themselves, including the adaptive and innate immune systems of vertebrates and the CRISPR and restriction:modification systems of bacteria. Viruses have developed potent countermeasures to subvert these systems, and this perpetual arms race has been a strong driving force in evolution throughout the history of life on Earth. CBASS (cyclic-oligonucleotide-based antiphage signalling sys",{"id":570,"funder":7,"programme":8,"title":571,"piName":10,"institution":572,"country":27,"year":13,"amount":573,"abstract":574},"cordis-european-research-council-award-101020057","Planetary systems around white dwarfs","UNIVERSITY OF WARWICK","€2,535,290","In the 25 years since the discovery of 51 Peg b, we went from not knowing if the Solar system is a fluke of Nature to realising that it is totally normal for stars to have planets. The common fate of practically all planet hosts is that they will eventually evolve into white dwarfs, the Earth-sized embers that are the evolutionary end-points of most stars. Many of the known planets will survive the post main-sequence evolution of their host stars - in the solar system, this includes Mars, and al",{"id":576,"funder":7,"programme":8,"title":577,"piName":10,"institution":465,"country":393,"year":13,"amount":578,"abstract":579},"cordis-european-research-council-award-101021272","Using clouds as a natural laboratory to improve precipitation forecast skills","€3,499,926","Clouds have been seeded since the 1940s. Aimed at inducing weather modification, the method uses chemicals to alter the microphysical processes within a cloud to enhance precipitation, suppress hail, or dissipate fog. While the concept of cloud seeding is not new, detailed knowledge about the underlying microphysical processes in clouds is still sparse. CLOUDLAB will tackle this gap by injecting different ice nucleating particle concentrations into supercooled stratus clouds to investigate relat",{"id":581,"funder":7,"programme":8,"title":582,"piName":10,"institution":399,"country":393,"year":13,"amount":583,"abstract":584},"cordis-european-research-council-award-885076","Chemical Space for Antimicrobials on a Peptide Basis","€2,495,285","Multidrug resistant (MDR) bacteria represent a global public health threat against which new drugs are urgently needed. Antimicrobial peptides (AMPs), mostly derived from naturally occurring linear or cyclic peptides, can contribute to solving the problem. AMPs are already in clinical use, do not easily lead to resistance, and can rely on a strong manufacturing sector and established protocols for clinical development. However, most AMPs are degraded by proteases and have poor pharmacokinetics.S",{"id":586,"funder":7,"programme":8,"title":587,"piName":10,"institution":518,"country":238,"year":13,"amount":588,"abstract":589},"cordis-european-research-council-award-101021347","Beyond solving static datasets: Deep learning from streaming data","€2,499,065","Data is key for modern AI solutions, especially deep learning. Unfortunately, the data-driven nature of deep learning that makes it so powerful when dealing with complex and high-dimensional data, is also at the core of its main weakness: a model is only as good as the data it builds on. In this project, we want to tackle some strong limitations inherent to the standard machine learning paradigm, which makes restrictive assumptions that are problematic in many real-world (“in the wild”) conditio",{"id":591,"funder":7,"programme":8,"title":592,"piName":10,"institution":593,"country":34,"year":13,"amount":594,"abstract":595},"cordis-european-research-council-award-101021345","T-cell-induced immune programming and degeneration of the neuronal tissue during chronic autoimmunity","UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS","€2,374,863","The TOPIC of this proposal is how a T-cell-driven autoimmune process can transform the brain into a chronically inflamed tissue afflicted by progressive neurodegeneration. The brain is considered to be an immune-privileged organ because immune cells have restricted access to its tissue and its resident cells can only exert limited immune functions. However, in the course of multiple sclerosis, a T-cell-induced chronic autoimmune disease of the brain, such aspects change dramatically and the brai",{"id":597,"funder":7,"programme":8,"title":598,"piName":10,"institution":599,"country":145,"year":13,"amount":74,"abstract":600},"cordis-european-research-council-award-884900","Quantum Physics with Attosecond Pulses","LUNDS UNIVERSITET","This project lies at the crossing of attosecond science, photoionization of atoms and molecules and quantum optics. Progress in the performances of the attosecond sources, in particular regarding repetition rate, now enables us to perform photoionization studies of atoms and molecules using advanced coincidence\u002Fthree dimensional momentum techniques. Adding an additional dimension, the phase, which is accessible by attosecond interferometric techniques, we will able to follow in time the quantum ",{"id":602,"funder":7,"programme":8,"title":603,"piName":10,"institution":604,"country":179,"year":13,"amount":10,"abstract":605},"cordis-european-research-council-award-884442","What drives human behavior regarding global coastal migration and adaptation in response to sea level rise and extreme flood events?","STICHTING VU","Future sea level rise (SLR), extreme flood events, and urbanization pressure will increase coastal flood risk, and in the absence of costly flood protection measures in numerous regions, millions of coastal residents will be forced to migrate to safer locations. This research addresses the significant challenge these trends pose to adaptation and migration policy: Which coastal areas will be protected, and in which regions will coastal migration become the inevitable adaptation option?To tackle ",{"id":607,"funder":7,"programme":8,"title":608,"piName":10,"institution":609,"country":257,"year":13,"amount":610,"abstract":611},"cordis-european-research-council-award-101020127","What is bedouin-type Arabic? The linguistic and socio-historical realities behind the millennia-old dichotomous concept of nomadic and sedentary people in the Middle East and North Africa","UNIVERSITAT WIEN","€2,455,891","This project will investigate the linguistic differences between originally nomadic and sedentary people, i.e. one of the key concepts in the history of the Arabic language and the grouping of its contemporary spoken varieties. While the dichotomy between Bedouins and sedentary communities is of crucial importance for the (social) history, economy, and linguistic identity of the Arabic speaking Middle East and North Africa, it is still insufficiently understood. WIBARAB aims to establish for the",{"id":613,"funder":7,"programme":8,"title":614,"piName":10,"institution":615,"country":27,"year":13,"amount":616,"abstract":617},"cordis-european-research-council-award-101020453","Behavioural Principles of Large-Scale Cooperation","THE UNIVERSITY OF NOTTINGHAM","€2,496,465","Global warming and Covid19 are two prime examples of problems that require cooperation at a very large scale. A failure to cooperate, that is, to act in one’s self-interest rather than the collective interest, could spell a bleak future for humanity. When are people prepared to play their part in the solution of these fundamental problems? Current behavioural models of cooperation from across the social sciences, including economics, are inadequate for answering this fundamental question, becaus",{"id":619,"funder":7,"programme":8,"title":620,"piName":10,"institution":621,"country":27,"year":13,"amount":10,"abstract":622},"cordis-european-research-council-award-885220","The dynamics of sign language grammar: Morphology, language change, iconicity, and social structure in signing communities","THE UNIVERSITY OF BIRMINGHAM","SignMorph aims to address two of the most fundamental questions in the language sciences: how much do the languages of the world resemble each other and how do they differ, and what factors account for both the cross-linguistic similarities and the differences? SignMorph will provide answers to these questions about the nature of human language through a focus on the sign languages of deaf communities.  This project will also be the first to focus on key aspects of the grammar across three disti",{"id":624,"funder":7,"programme":8,"title":625,"piName":10,"institution":626,"country":179,"year":13,"amount":74,"abstract":627},"cordis-european-research-council-award-101019998","Fundamental Research into Understanding the Molecular structure of eleKtrochemical INterfaces","UNIVERSITEIT LEIDEN","The FRUMKIN project aims to develop and test a new model for the electric double-layer structure of the electrode-electrolyte interface and to investigate the impact of this double-layer structure on the kinetics and selectivity of electrochemical and electrocatalytic reactions. The inspiration for this new model comes from my own recent work that the classical Gouy-Chapman-Stern model for the electric double layer fails to properly describe the interface between an aqueous electrolyte and singl",{"id":629,"funder":7,"programme":8,"title":630,"piName":10,"institution":626,"country":179,"year":13,"amount":10,"abstract":631},"cordis-european-research-council-award-885301","Quasars in a Neutral Universe: Chronicling the History of Reionization, Enrichment, and Black Hole Growth","How the first luminous sources reionized diffuse baryons in the intergalactic medium (IGM) is one of the most fundamental open questions in cosmology.  The latest CMB constraints suggest reionization occurred at z ~ 7-8, within the realm of the highest redshift quasars known. The overarching impetus of this proposal is that Euclid's imminent discovery of scores of bright quasar beacons in a neutral universe, combined with the exquisite sensitivity of JWST, will enable a set of qualitatively new ",{"id":633,"funder":7,"programme":8,"title":634,"piName":10,"institution":635,"country":34,"year":13,"amount":636,"abstract":637},"cordis-european-research-council-award-101018170","Emergent Complexity from strong Interactions","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","€2,269,197","The least understood part of the so successful Standard Model of the strong and electroweak forcesis the formation of strongly interacting composites, like hadrons, atomic nuclei and hypernuclei. Inaddition, the nucleosynthesis in the Big Bang and in stars is fine-tuned at various places, whichimmediately leads to the question how much these fine-tunings can be offset to still lead to an habitableuniverse?Over the last decade, the PI and his collaborators have further improved the chiral effecti",{"id":639,"funder":7,"programme":8,"title":640,"piName":10,"institution":244,"country":27,"year":13,"amount":641,"abstract":642},"cordis-european-research-council-award-101019465","Mirror symmetry in Algebraic Geometry","€2,434,492","Mirror symmetry is a phenomenon first discovered by string theorists in 1989. This phenomenon, when described in mathematical language, posits that certain kinds of geometric objects, known as Calabi-Yau manifolds, come in pairs X, Y. Further, mirror symmetry posits an intricate relationship between the geometry of the members of the pair. This relationship can be summarized by the rough statement that the symplectic geometry of X is isomorphic to the complex geometry of Y. Mathematical explorat",{"id":644,"funder":7,"programme":8,"title":645,"piName":10,"institution":646,"country":179,"year":13,"amount":647,"abstract":648},"cordis-european-research-council-award-884139","Humanitarian governance: accountability, advocacy, alternatives","ERASMUS UNIVERSITEIT ROTTERDAM","€2,499,591","How is humanitarian governance evolving in response to global and local changes, and how do civil society actors and crisis-affected people shape humanitarian governance ‘from below’ using accountability and advocacy?Growing humanitarian need, increasing population displacement, and expanding impact of climate-related disasters multiply the challenges of preserving life and dignity in crisis-affected populations. At-risk populations are increasingly difficult to capture using the traditional cat",{"id":650,"funder":7,"programme":8,"title":651,"piName":10,"institution":555,"country":196,"year":13,"amount":652,"abstract":653},"cordis-european-research-council-award-101020038","A Network Science Approach to Social Cohesion in European Societies","€2,447,501","As European societies are becoming increasingly unequal, diverse, and polarised, concerns about their cohesion are growing. In this light, it is surprising that social cohesion research has almost entirely ignored one of its core dimensions: relationships. Broad acquaintanceship networks, which connect each individual to hundreds of others through both intimate and superficial relationships, have long been assumed to bind societies together and provide a sense of community and solidarity. Noneth",{"id":655,"funder":7,"programme":8,"title":656,"piName":10,"institution":657,"country":34,"year":13,"amount":658,"abstract":659},"cordis-european-research-council-award-885150","Nuclear Theory from First Principles","RUHR-UNIVERSITAET BOCHUM","€2,499,206","Nuclear physics aims at understanding the emergence and properties of complex structures like atomic nuclei from QCD, the underlying theory of the strong interaction, and addresses some of the Big Science Questions including the origin of the elements, the limits of nuclear stability, searches for physics beyond the Standard Model and physics of neutron stars. Answering these questions requires a reliable theoretical approach to nuclear structure and reactions. Chiral effective field theory (EFT",{"id":661,"funder":7,"programme":8,"title":662,"piName":10,"institution":663,"country":162,"year":13,"amount":10,"abstract":664},"cordis-european-research-council-award-884927","A Social Identity Model of Trauma and Identity Change: A Novel Theory of Post-Traumatic Stress, Resilience and Growth","UNIVERSITY OF LIMERICK","This project will develop a new social paradigm for trauma research that will allow us to understand post-traumatic stress and facilitate post-traumatic resilience and growth. This new paradigm holds that changes in social identities – the sense of self we derive from being part of valued groups – are at the heart of post traumatic outcomes. This breakthrough project will develop a synergistic model explaining how physiological, clinical and socio-political consequences of stress and trauma resu",{"id":666,"funder":7,"programme":8,"title":667,"piName":10,"institution":668,"country":27,"year":13,"amount":669,"abstract":670},"cordis-european-research-council-award-882601","Deep Decarbonisation: The Democratic Challenge of Navigating Governance Traps","UNIVERSITY OF EAST ANGLIA","€2,395,525","The standard advice to politicians confronting long-term challenges such as decarbonisation is to adopt time-consistent commitment devices such as binding policies. Yet politicians appear unable to do this, greatly imperilling the achievement of the 1.5 and 2oC limits in the landmark Paris Agreement.The state-of-the art struggles to explain the causes, and hence the solutions, to this impasse. Political scientists argue that politicians fear retribution at the next election; psychologists claim ",{"id":672,"funder":7,"programme":8,"title":673,"piName":10,"institution":674,"country":41,"year":13,"amount":675,"abstract":676},"cordis-european-research-council-award-885155","Multiscale modeling and simulation approaches for biomedical ultrasonic applications","KEMIJSKI INSTITUT","€2,490,750","Ultrasound-guided drug and gene delivery (USDG) enables controlled and spatially precise delivery of drugs and macromolecules, encapsulated in microbubbles (MBs) and submicron gas vesicles (GVs), to target areas such as cancer tumors. It is a non-invasive, high precision, low toxicity process with drastically reduced drug dosage. These advantages open doors to numerous biomedical applications, from sonothrombolysis to bloodbrain barrier opening. However, the progress and deployment of this techn",{"id":678,"funder":7,"programme":8,"title":679,"piName":10,"institution":680,"country":12,"year":13,"amount":681,"abstract":682},"cordis-european-research-council-award-885026","The Transnational Divide: Local Triggers, Social Networks, and Group Identities","EUROPEAN UNIVERSITY INSTITUTE","€2,498,412","TRANSNATIONAL seeks to explain a surprising and consequential feature of contemporary democratic politicsthe intensity of polarization on immigration, Europe, and climate change. While recent research has made impressive advances in understanding individual attitudes and party-political competition, there is currently no empirically verified theory of how a persons social context shapes their response to issues that arise on the political agenda. Without such a framework we cannot understand the",{"id":684,"funder":7,"programme":8,"title":685,"piName":10,"institution":686,"country":196,"year":13,"amount":687,"abstract":688},"cordis-european-research-council-award-101019003","Clip-off Chemistry: Design and Synthesis of New Materials via Programmable Disassembly of Reticular Materials","FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA","€2,505,645","Historically, innovations in synthetic methods and reactions have changed the way scientists think about designing and synthesizing materials and molecules. Indeed, novel synthetic methods not only unlock access to previously unattainable structures, but also inspire new concepts as to how we design and build materials to address global social, economic and industrial needs. The project that I propose here, CLIPOFF-CHEM, centers on the demonstration of a novel synthetic methodology that I have n",{"id":690,"funder":7,"programme":8,"title":691,"piName":10,"institution":692,"country":34,"year":13,"amount":74,"abstract":693},"cordis-european-research-council-award-885008","Metaplasia as an adaptive response to chronic microbial infections","CHRISTIAN-ALBRECHTS-UNIVERSITAET  ZU KIEL","The epithelial surfaces are frequently affected by harsh encounters, thus it is not surprising that most cancers originate here. Several chronic bacterial infections have been implicated in human cancers, with Helicobacter pylori (Hp) representing the paradigm of a cancer-inducing bacterium. The gastric pathology of infection tends to progress from mild symptoms, via active gastritis, atrophy, gastric intestinal metaplasia (GIM) and dysplasia towards gastric adenocarcinoma. Intriguingly, GIM is ",{"id":695,"funder":7,"programme":8,"title":696,"piName":10,"institution":244,"country":27,"year":13,"amount":697,"abstract":698},"cordis-european-research-council-award-101019302","Many-body Dynamics and Universality in Flatland","€2,425,898","One of the great successes of the last-century physics was recognising that many complex and seemingly disparate many-particle systems are fundamentally alike. This allowed the classification of the equilibrium states of matter into universality classes, based on their basic properties such as symmetries and the form of the interparticle interactions. At the heart of this classification is the universal collective behaviour, insensitive to the microscopic details, displayed by systems close to p",{"id":700,"funder":7,"programme":8,"title":701,"piName":10,"institution":702,"country":34,"year":13,"amount":703,"abstract":704},"cordis-european-research-council-award-101019972","Direct Temporal Synthesis of Terahertz Light Fields Enabling Novel Computational Imaging","BERGISCHE UNIVERSITAET  WUPPERTAL","€2,477,947","The terahertz (THz) frequency range is widely considered as the most challenging and under-developed frequency range due to the lack of technologies to effectively bridge the transition region between microwaves (below 100 GHz) and optics (above 10,000 GHz). Although THz radiation would be perfect for material identification and as a safe alternative to X-rays for producing high resolution images of the interior of opaque objects, first a fundamentally new approach is needed to establish novel d",{"id":706,"funder":7,"programme":8,"title":707,"piName":10,"institution":708,"country":34,"year":13,"amount":709,"abstract":710},"cordis-european-research-council-award-101018743","Opera and the Politics of Empire in Habsburg Europe, 1815-1914","UNIVERSITAET LEIPZIG","€2,499,998","TRANSOPERA investigates the politics of opera in the Habsburg Empire between the Congress of Transopera investigates the politics of opera in the Habsburg Empire between the Congress of Vienna and the outbreak of World War One. With its emphasis on transnational exchanges between the Empires different parts and on Austrias multinational concept of state, my project challenges traditional narratives that have tended to highlight the role of opera as a tool of political nationalism. Instead, the E",{"id":712,"funder":7,"programme":8,"title":713,"piName":10,"institution":714,"country":27,"year":13,"amount":513,"abstract":715},"cordis-european-research-council-award-101021133","Molecular choreography of bacterial chemotaxis signalling","DIAMOND LIGHT SOURCE LIMITED","For nearly six decades, chemotaxis - a ubiquitous biological behaviour enabling the movement of a cell or organism toward or away from chemicals -has served as a paradigmatic model for the study of cellular sensory signal transduction and motile behavior. The relatively simple chemotaxis machinery of E. coli is the best understood signal transduction system and serves as a powerful tool for investigating the molecular mechanisms that proteins use to detect, process, and transmit signals. The sen",{"id":717,"funder":7,"programme":8,"title":718,"piName":10,"institution":719,"country":720,"year":13,"amount":721,"abstract":722},"cordis-european-research-council-award-101018401","Social Inclusion and the Political Economy of Education: Building Social Capital in Ethnic Diversity","BILKENT UNIVERSITESI VAKIF","TR","€2,350,000","Human migratory flows are currently at an unprecedented scale. The majority of these flows concern forced displacements, turning into long-term settlements in host countries, making ethnic diversity a permanent feature of our societies. Managed incorrectly, rapid changes in ethnic composition can harm host communities social capital and give ways to ethnic conflicts and polarization. Given that immigration will remain an inevitable global reality for the foreseeable future, designing and impleme",{"id":724,"funder":7,"programme":8,"title":725,"piName":10,"institution":726,"country":12,"year":13,"amount":727,"abstract":728},"cordis-european-research-council-award-101020342","Targeting DNA repair pathways, sparking anti cancer immunity","UNIVERSITA DEGLI STUDI DI TORINO","€2,489,232","This project will test for the first time the hypothesis that therapeutic inactivation of DNA repair pathways in cancer cells can be exploited for patient benefit by reawakening an anti-tumor immune response.Genomic instability and molecular heterogeneity, which occur in cancer cells with DNA repair deficiencies, fuel tumour progression and are associated with poor outcome. An exception is represented by Mismatch repair (MMR) deficient cancers as these tumours are exceedingly genetically heterog",{"id":730,"funder":7,"programme":8,"title":731,"piName":10,"institution":599,"country":145,"year":13,"amount":74,"abstract":732},"cordis-european-research-council-award-101019147","Dynamic Properties of Ferroelectric III-V MOSFETs","The discovery of ferroelectric characteristics in annealed HfO2–based films opens a wide range of applications not only in memory and logic, but the results will enable new scientific directions for instance in reconfigurable electronics. So far, ferroelectric films have been investigated in metal-insulator-metal structures suitable for back-end-of-line integration. They have also been introduced onto Si and two-dimensional materials. However, there is a gap of knowledge with lack of science and",{"id":734,"funder":7,"programme":8,"title":735,"piName":10,"institution":244,"country":27,"year":13,"amount":736,"abstract":737},"cordis-european-research-council-award-101020478","The evolutionary landscape of modern human origins in Africa","€2,645,312","Our understanding of the origins of our species, Homo sapiens, has undergone a major shift. New fossils, dates and genomic studies have consolidated our African origin. Yet, they also indicate a deeper past, involving multiple events. These events stretch to nearly three quarters of a million years ago (Ma), and take the problem of modern human origins into an entirely different climatic and ecological context. From 1.4 Ma, climate dynamics changed, initiating a 1 million-year period (EMPT) duri",{"id":739,"funder":7,"programme":8,"title":740,"piName":10,"institution":609,"country":257,"year":13,"amount":741,"abstract":742},"cordis-european-research-council-award-883669","A micro-scale perspective on alpine floras under climate change. Linking observations and models to improve our understanding of the future of European high mountain plants","€2,493,795","The diversity of organisms, one of the most striking features of life on Earth, is under threat, and climate change may become a major driver of the biodiversity crisis in the decades to come. However, climate effects on species will vary across ecosystems and regions. The fate of the rich and peculiar alpine flora in a warming world is particularly contentious. While some researchers expect massive loss of cold-adapted plants because they have little options to escape the heat (mountaintop exti",{"id":744,"funder":7,"programme":8,"title":745,"piName":10,"institution":746,"country":747,"year":13,"amount":74,"abstract":748},"cordis-european-research-council-award-883219","Early Arabic Printing for the Arab Christians. Cultural Transfers between Eastern Europe and the Ottoman Near-East in the 18th century","INSTITUTUL DE STUDII SUD EST EUROPENE","RO","The main objective of the Project is to examine the circumstances and outcomes of printing in Arabic with Arabic type in the 18th century Greater Syria  (modern Syria and Lebanon), for Byzantine-rite and Catholic Arab Christians. It addresses the connections between Eastern Europe and the Arab Christians of the Ottoman Empire and the social progress brought by the print culture. It focuses on the transfer of printing technology from Moldavia and Wallachia (the Romanian Principalities) to the Ott",{"id":750,"funder":7,"programme":8,"title":751,"piName":10,"institution":752,"country":27,"year":13,"amount":753,"abstract":754},"cordis-european-research-council-award-101020088","Causes and MEchanisms foR non-atopic Asthma in children","LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER","€2,612,117","Until 20 years ago it was widely believed that asthma was an allergic\u002Fatopic disease involving atopic inflammation of the airways. Work that I and others have done has now shown that non-atopic asthma is much more important than was previously recognised. This has been confirmed by my ERC-funded AsthmaPhenotypes study, in both high-income countries (HICs) and low-and-middle-income countries (LMICs). This is important both in terms of the prevention of non-atopic asthma, and also in terms of its ",{"id":756,"funder":7,"programme":8,"title":757,"piName":10,"institution":758,"country":220,"year":13,"amount":759,"abstract":760},"cordis-european-research-council-award-101019712","Probing the limits of quantum mechanics and gravity with micromechanical oscillators","AALTO KORKEAKOULUSAATIO SR","€2,499,033","Quantum mechanics is a leading success story in science, originally devised to explain matter and energy at the atomic scale. Quantum superpositions and entanglement can produce distinct phenomena unseen in classical physics. Rather recently, such effects have been shown to hold also for macroscopic degrees of freedom, including the motion of somewhat massive objects. However, despite its success at describing phenomena in the low-energy limit, quantum mechanics is incompatible with general rela",{"id":762,"funder":7,"programme":8,"title":763,"piName":10,"institution":392,"country":393,"year":13,"amount":764,"abstract":765},"cordis-european-research-council-award-101019620","Theory of particle collider processes at ultimate precision","€2,459,915","The Large Hadron Collider (LHC) at CERN probes the interaction of elementary particles at unprecedented energy and to very high precision. The full exploitation of the upcoming data from the LHC relies on a close interplay between theory and experiment, which calls in particular for highly accurate theoretical predictions. This theoretical accuracy can be achieved only though the expansion of the fundamental scattering amplitudes to sufficiently high order in perturbation theory.This project aim",{"id":767,"funder":7,"programme":8,"title":768,"piName":10,"institution":769,"country":770,"year":13,"amount":771,"abstract":772},"cordis-european-research-council-award-885666","Smart-Contract Protocols: Theory for Applications","UNIWERSYTET WARSZAWSKI","PL","€2,496,370","Smart contracts are formal agreements that take the form of computer programs. They are typically written down, and automatically executed, on blockchains. Smart-contract protocols are algorithms that describe how these contracts operate in multiparty settings. Due to the large number of potential applications, interest in this field has exploded in the last few years. Also, the PI has generated important results through his work in this area.  The ambitious goal of PROCONTRA is to transfigure t",{"id":774,"funder":7,"programme":8,"title":775,"piName":10,"institution":776,"country":777,"year":13,"amount":10,"abstract":778},"cordis-european-research-council-award-101017697","Control of light vehicle-manipulator systems","NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU","NO","The advent of light and freely moving autonomous robots that can perform complex and versatile operations in challenging environments, involving highly precise and forceful physical interactions, would represent a scientific breakthrough. In such robots, kinematics and dynamics will be intimately connected. Although solutions for specific use cases do exist, a control-theoretical framework, capable of dealing with this tight coupling in a wide range of contexts, is lacking.  In CRÈME, I will est",{"id":780,"funder":7,"programme":8,"title":781,"piName":10,"institution":626,"country":179,"year":13,"amount":782,"abstract":783},"cordis-european-research-council-award-101019474","Pathways, Memory and Information Processing in Matter","€2,499,420","Imagine squeezing a crumpled plastic sheet – what is its response? For complex materials – crumpled sheets, granular media, glassy materials – tiny forces already cause a nonlinear response, associated with hopping in the energy landscape, for which we lack a coherent description. The central tenet of this proposal is that this hopping allows complex materials to process information. I propose to understand and unlock the full potential of such complex materials. Central questions are:- How can ",{"id":785,"funder":7,"programme":8,"title":786,"piName":10,"institution":297,"country":34,"year":13,"amount":787,"abstract":788},"cordis-european-research-council-award-883631","Dynamic charging at moving contact lines","€2,474,500","Water drops sliding over hydrophobic surfaces can lead to surface charging. In contrast to charging caused by friction between two solid phases, drop slide electrification is largely unexplored. Slide electrification has been consistently reported, but results are difficult to reproduce. No theory or quantitative explanation currently exists. One reason for the lack of quantitative understanding is that the deposition of charge is a non-equilibrium effect and depends essentially on microscopic p",{"id":790,"funder":7,"programme":8,"title":791,"piName":10,"institution":792,"country":20,"year":13,"amount":793,"abstract":794},"cordis-european-research-council-award-883313","Raising co-creativity in cyber-human musicianship","INSTITUT DE RECHERCHE ET DE COORDINATION ACOUSTIQUE MUSIQUE - IRCAM","€2,470,250","Raising co-creativity in cyber-human musicianshipDigital cultures are increasingly pushing forward a deep interweaving between human creativity and autonomous computation capabilities of surrounding environments, modeling joint human-machine action into new forms of shared reality involving symbiotic interactions. In the artistic, cultural or educative fields, co-creativity between humans and machines will bring about the emergence of distributed information structures, creating new performative",{"id":796,"funder":7,"programme":8,"title":797,"piName":10,"institution":798,"country":34,"year":13,"amount":74,"abstract":799},"cordis-european-research-council-award-885281","Probing r-process nucleosynthesis through its electromagnetic signatures","GSI HELMHOLTZZENTRUM FUR SCHWERIONENFORSCHUNG GMBH","The lightest chemical elements –Hydrogen and Helium– were created about a minute after the Big Bang. Elements up to Iron are forged by fusion reactions in stars. Heavy elements between Iron and Uranium are produced by a sequence of neutron captures and beta-decays known as rapid neutron capture or r process. The freshly synthesized r-process elements undergo radioactive decay through various channels depositing energy in the ejecta that powers an optical\u002Finfrared transient called “kilonova” whos",{"id":801,"funder":7,"programme":8,"title":802,"piName":10,"institution":421,"country":27,"year":13,"amount":74,"abstract":803},"cordis-european-research-council-award-101020641","Metabolic mechanisms underpinning obesity-driven pancreatic cancer","Pancreatic cancer is one of the most lethal malignancies, showing a high rate of metastatic spread and a dismal prognosis. With almost no effective treatment options, new therapies to treat this devastating disease are urgently needed. Such advances will depend on a better understanding of the mechanisms that drive pancreas cancer progression. Previous work has revealed two interesting features of pancreas cancer on which this proposal is built. Firstly, pancreas cancers contain an extremely hig",{"id":805,"funder":7,"programme":8,"title":806,"piName":10,"institution":297,"country":34,"year":13,"amount":807,"abstract":808},"cordis-european-research-council-award-101020262","New routes for magnetic resonance spectroscopy of biomolecules by combining EPR and NMR methods","€2,443,125","Detection of magnetic nuclei via magnetic resonance spectroscopy (NMR\u002FEPR) or imaging (MRI) is one of the most important tools to achieve structural and functional information in natural sciences. Latest developments in this field are taking advantage of the larger (about three orders of magnitude) spin polarization of unpaired electrons in paramagnetic molecules to tremendously enhance the sensitivity of nuclear magnetic resonance. However, most protocols still suffer from several bottlenecks a",{"id":810,"funder":7,"programme":8,"title":811,"piName":10,"institution":244,"country":27,"year":13,"amount":812,"abstract":813},"cordis-european-research-council-award-101019498","Robust statistical methodology and theory for large-scale data","€2,050,068","Modern technology allows large-scale data to be collected in many new forms, and their underlying generating mechanisms can be extremely complex.  In fact, an interesting (and perhaps initially surprising) feature of large-scale data is that it is often much harder to feel confident that one has identified a plausible statistical model.  This is largely because there are so many forms of model violation and both visual and more formal statistical checks can become infeasible.  It is therefore vi",{"id":815,"funder":7,"programme":8,"title":816,"piName":10,"institution":459,"country":145,"year":13,"amount":817,"abstract":818},"cordis-european-research-council-award-885360","Biophysics in gene regulation - A genome wide approach","€2,411,410","In this project, we will develop and use technology that combines synthetic genomics and live-cell imaging. These methods make it possible to study the intracellular biophysics at single-molecule detail in thousands of genetically different bacterial strains in parallel. Our approach is based on in situ genotyping of a barcoded strain library after phenotyping has been performed by live-cell imaging. Within the scope of the proposed project, the new technology will be used to solve mechanistic a",{"id":820,"funder":7,"programme":8,"title":821,"piName":10,"institution":822,"country":145,"year":13,"amount":823,"abstract":824},"cordis-european-research-council-award-101021166","Gases in Water","STOCKHOLMS UNIVERSITET","€2,295,625","Is there “hidden” structure in normal liquid water? Do nanoscopic structural heterogeneities in ambient water exist and affect solution chemistry? In this project we will focus on structural fluctuations in simulations of liquid water as observed through the enhancement of the isothermal compressibility. From both experiment and theory a two-state picture of water is emerging with fluctuations between high- (HDL) and low-density (LDL) local structures. The structure of these is unknown. Moreover",{"id":826,"funder":7,"programme":8,"title":827,"piName":10,"institution":828,"country":179,"year":13,"amount":829,"abstract":830},"cordis-european-research-council-award-101019978","Speedmeter: Quantum back-action noise-free interferometry for improving the science capabilities of future gravitational wave observatories","UNIVERSITEIT MAASTRICHT","€2,175,941","The discoveries enabled by observations of gravitational waves (GW) from merging black holes and neutron stars provided us with a stunning glimpse of the immense potential of GW multi-messenger astronomy and cosmology. In order to discover new phenomena and better understand the constituents of the Universe and the forces driving it, it is vital to improve the sensitivity of future GW observatories. Indeed, to maximise the observation capacity of future GW observatories such as the Einstein Tele",{"id":832,"funder":7,"programme":8,"title":833,"piName":10,"institution":834,"country":12,"year":13,"amount":835,"abstract":836},"cordis-european-research-council-award-882588","Priscian’s Ars grammatica in European Scriptoria. A Millennium of Latin and Greek Scholarship","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","€2,486,375","Written at the beginning of the 6th century AD in the bilingual context of Constantinople, the Ars Prisciani, in 18 books, is the last and greatest Latin grammar handbook of Antiquity. Bringing together the inheritance of Latin and Greek grammatical traditions, it stands as a milestone in the history of linguistic speculation and is an important source of fragments of lost literary works. The deep impact of this text on European culture falls beyond its original scope. Conceived to teach Latin t",{"id":838,"funder":7,"programme":8,"title":839,"piName":10,"institution":333,"country":179,"year":13,"amount":840,"abstract":841},"cordis-european-research-council-award-101019932","Quantum Electron Wavepacket Spectroscopy","€2,495,485","Can we shape an electron wavepacket in space and time? Can we tailor it to probe material properties that are currently inaccessible? Recent work has shown that high-energy electrons (80-200 keV) interacting with strong light fields can absorb or release quantized energy packets equal to the photon energy. This dresses the electron into a superposition state composed of a spectrum of energy-loss and -gain sidebands. Here we exploit this Photon-Induced Near-field Electron Microscopy (PINEM) effec",{"id":843,"funder":7,"programme":8,"title":844,"piName":10,"institution":465,"country":393,"year":13,"amount":845,"abstract":846},"cordis-european-research-council-award-101018300","Bordering Europe: Boundary Formation and European Integration","€2,477,206","Integration crises and geopolitical shifts have put the borders of the European Union (EU) in the focus of attention and contestation. Current developments highlight how strongly European integration is affected by outside events and cross-border transactions. Yet theories of European integration focus almost exclusively on the internal boundaries between the member states. EUROBORD therefore develops and tests a novel ‘bordering theory’ aiming to explain how external boundary developments affec",{"id":848,"funder":7,"programme":8,"title":849,"piName":10,"institution":850,"country":34,"year":13,"amount":851,"abstract":852},"cordis-european-research-council-award-101019765","Kiwellins in the plant defense against pathogenic invaders","PHILIPPS UNIVERSITAET MARBURG","€2,344,343","Plant diseases caused by pathogenic fungi critically affect global food security and plant ecology. How plants defend themselves against pathogenic invaders and the molecular weaponry involved is still far from being complete. Kiwellin proteins (KWL) represent an emerging class of highly diverse proteins with antibody-like properties serving as countermeasures of plants against virulence factors secreted by pathogenic fungi. The aim of this ERC-project is to establish the functional, structural ",{"id":854,"funder":7,"programme":8,"title":855,"piName":10,"institution":572,"country":27,"year":13,"amount":856,"abstract":857},"cordis-european-research-council-award-885698","Generating New Evidence to Address Violence Against Women: Realizing Women’s Rights","€2,470,086","Violence against women (VAW) is a fundamental cause of gender inequality and a substantial constraint on women’s lives, but it has drawn significantly less intellectual curiosity from economists than aspects of gender inequality such as the pay gap. I propose to redress this by acquiring, generating and analysing unavailable or under-used data using techniques for causal identification with a view to producing a rich tapestry of scientific evidence to guide policy and further scholarship. This i",{"id":859,"funder":7,"programme":8,"title":860,"piName":10,"institution":861,"country":179,"year":13,"amount":862,"abstract":863},"cordis-european-research-council-award-101021218","Portable, accessible and sustainable magnetic resonance","ACADEMISCH ZIEKENHUIS LEIDEN","€2,493,715","MRI is a key modality in clinical care, with well over 150 million scans performed annually for diagnosis and treatment monitoring. Its major strengths are multi-contrast and the lack of ionizing radiation. However, its Achilles-heel is cost: typically millions of euros to purchase, site, and maintain, and also requires highly skilled technicians. As a result, MRI is available only in larger hospitals in the developed world, and unlike other imaging modalities plays little role in population scr",{"id":865,"funder":7,"programme":8,"title":866,"piName":10,"institution":232,"country":220,"year":13,"amount":867,"abstract":868},"cordis-european-research-council-award-883417","Intergovernmental Organizations between Mission and Market: International Institutional Law and the Private Sector","€2,407,105","Intergovernmental organizations (IGOs) such as the World Health Organization or International Maritime Organization have always been assumed to work for the public good. Yet, they also engage the private sector in many ways. Some are funded by the private sector or set up public-private partnerships; IGOs themselves act and compete on markets when procuring goods and services or when marketing their own services; and their operations and standard-setting activities inevitably affect the distribu",{"id":870,"funder":7,"programme":8,"title":871,"piName":10,"institution":872,"country":145,"year":13,"amount":10,"abstract":873},"cordis-european-research-council-award-884608","A PRECISION CELL REPLACEMENT STRATEGY FOR  PARKINSON’S DISEASE","KAROLINSKA INSTITUTET","Parkinson’s disease (PD) is a progressive incurable neurodegenerative disorder characterized by the loss of substantia nigra neurons (A9\u002FSNs), a subset of midbrain dopaminergic neurons (mDAs) that are required for functional re-innervation of the striatum. Current treatments for PD are symptomatic and do not prevent disease progression. Proof-of-concept clinical studies using human fetal midbrain tissue for transplantation have shown that replacement of mDAs can change the course of PD. Human pl",{"id":875,"funder":7,"programme":8,"title":876,"piName":10,"institution":877,"country":27,"year":13,"amount":878,"abstract":879},"cordis-european-research-council-award-883798","Epigenetic regulation of cell fate during early mammalian development","THE BABRAHAM INSTITUTE","€2,351,249","Formation of the three primary germ layers during gastrulation is an essential step in the establishment of the vertebrate body plan. Single cell RNA-sequencing has identified major transcriptional changes associated with germ layer specification. Global epigenetic reprogramming accompanies these changes, but the role of the epigenome in regulating early cell fate choice is poorly understood. We are systematically charting this important developmental progression by single cell multi-omics, trac",{"id":881,"funder":7,"programme":8,"title":882,"piName":10,"institution":883,"country":179,"year":13,"amount":10,"abstract":884},"cordis-european-research-council-award-884902","Rational Design of Soft Hierarchical Materials with Responsive Functionalities: Machine learning Soft Matter to create Soft Machines","UNIVERSITEIT UTRECHT","Nature displays fascinating examples of self-assembled materials that reconfigure and respond to external stimuli, e.g. chameleons change color for camouflage, pine cones release seeds upon a change in humidity. Advances in colloid synthesis have resulted in a diversity of self-assembled nanostructures with interesting functional properties. These nanostructures are however passive!The aim of this project is to explore the new physics that emerges when static nanostructures are elastically coupl",{"id":886,"funder":7,"programme":8,"title":887,"piName":10,"institution":599,"country":145,"year":13,"amount":74,"abstract":888},"cordis-european-research-council-award-885003","MOVING FROM BIOMARKERS TO MECHANISM ORIENTED PREVENTION OF CARDIOMETABOLIC DISEASE","Increasing occurrence of obesity and diabetes is the major threat to cardiovascular health of our century. Whereas the field is saturated with “omics” strategies aimed at improving prediction of cardiometabolic disease (CMD), mechanism-orientated prevention strategies, which is what the population calls for, are lacking. We here propose three completely new and high-risk strategies to prevent CMD in large subsets of the population, who have elevated risk due to measurable endocrine abnormalities",{"id":890,"funder":7,"programme":8,"title":891,"piName":10,"institution":892,"country":196,"year":13,"amount":10,"abstract":893},"cordis-european-research-council-award-883922","Enantioselective C-H Oxidation Guided by Rational Catalyst Design","UNIVERSITAT DE GIRONA","Chemo- and enantioselective oxidation of aliphatic C-H bonds is a cornerstone reaction in metabolism. The ubiquitous presence of multiple and diverse C-H bonds in organic molecules is used by oxidative enzymes to deliver functionality and chirality to metabolite precursors, rapidly creating product diversity. Despite its huge potential in organic synthesis, non-enzymatic enantioselective C-H oxidation of aliphatic sites remains inaccessible and has never been incorporated in synthesis. Harnessin",{"id":895,"funder":7,"programme":8,"title":896,"piName":10,"institution":897,"country":196,"year":13,"amount":898,"abstract":899},"cordis-european-research-council-award-101021502","OPENING THE PATHWAY TOWARDS DENDRITIC ZEOLITES","Fundacion IMDEA Energia","€2,378,438","A great interest has arisen in the past ten years on synthetic materials exhibiting a dendritic 3D superstructure due to their outstanding and singular properties and to the high number of potential applications in a variety of relevant fields. Starting from silica nanoparticles, dendritic structures have now been extended to other compositions. However, the development of dendritic zeolites has remained elusive in spite of their huge scientific and industrial relevance. Being considered mature ",{"id":901,"funder":7,"programme":8,"title":902,"piName":10,"institution":903,"country":173,"year":13,"amount":904,"abstract":905},"cordis-european-research-council-award-101019693","An Eco-Metabolistic Framework for Sustainable Architecture","DET KONGELIGE DANSKE KUNST-AKADEMISSKOLER FOR ARKITEKTIR, DESIGN OG KONSERVERING","€2,410,027","This interdisciplinary project asks how we can rethink sustainable building practices through a bio-based material paradigm in response to the increasing global crisis of material depletion. Despite well-organised calls for action maturing into legislation and an attentive profession, architecture is proving reticent in this transition. Bio-based materials are fundamentally different to current building materials being characterised by their complex heterogeneity, unpredictable behaviours and li",{"id":907,"funder":7,"programme":8,"title":908,"piName":10,"institution":909,"country":910,"year":13,"amount":911,"abstract":912},"cordis-european-research-council-award-101020091","Brains that fire together wire together:  Interbrain plasticity underlies interaction-based learning","UNIVERSITY OF HAIFA","IL","€2,597,700","Traditionally, brain plasticity was viewed as a change occurring in synapses, brain structures and functional networks, within an individual brain.  Considering that social interactions play a major role in the acquisitions of skills and knowledge, I suggest a new approach for understanding interaction-based learning that focuses on inter-brain plasticity. The term coined here, inter-brain plasticity, will be defined as the short and long-term experience-dependent changes in brain-to-brain coupl",{"id":914,"funder":7,"programme":8,"title":915,"piName":10,"institution":916,"country":34,"year":13,"amount":917,"abstract":918},"cordis-european-research-council-award-884631","Launching, propagation and emission of relativistic jets from binary mergers and across mass scales","JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN","€2,875,000","Relativistic jets are marvellous astrophysical phenomena and formidable tools in multi-messenger astronomy. Revealed by uncountable examples, their existence has been the subject of observations for decades across a variety of length and timescales. They are associated with some of the most energetic phenomena in the universe, such as gamma-ray bursts (GRBs), microquasars, and active galactic nuclei (AGNs). As particle accelerators in GRBs, or as regulators of galaxy evolution in AGNs, relativis",{"id":920,"funder":7,"programme":8,"title":921,"piName":10,"institution":922,"country":27,"year":13,"amount":923,"abstract":924},"cordis-european-research-council-award-885184","Assembly and plasticity of inhibitory cortical networks by early learning experience","KING'S COLLEGE LONDON","€2,499,990","The extraordinary diversity of animal behaviors relies on the precise assembly and fine-tuning of synapses in neuronal circuits that adapt to an ever-changing environment. Hence, mature networks are the final expression of experiences accumulated throughout our life. Importantly, young brains are more amenable to learning that older brains, but the neural mechanisms underlying these differences remain largely unknown. In the cerebral cortex, for example, there are two main classes of neurons, ex",{"id":926,"funder":7,"programme":8,"title":927,"piName":10,"institution":850,"country":34,"year":13,"amount":928,"abstract":929},"cordis-european-research-council-award-883212","Earth-Abundant Metals with Exclusively Achiral Ligands for Sustainable Chiral-at-Metal Catalysis","€2,264,184","Asymmetric catalysis relies on the design of chiral catalysts and is dedicated to the economical generation of non-racemic chiral compounds, which are building blocks for the production of drugs, agricultural chemicals, flavors, fragrances, and materials. Chiral transition metal complexes constitute an important class of chiral catalysts and are typically synthesized by combining metal salts or organometallic precursors with chiral ligands. A neglected approach follows a different direction and ",{"id":931,"funder":7,"programme":8,"title":932,"piName":10,"institution":883,"country":179,"year":13,"amount":74,"abstract":933},"cordis-european-research-council-award-101019185","A Global Assessment of the Limits of Groundwater Use","Population growth and economic development have dramatically increased the demand for food and water. The resulting expansion of agriculture into areas with limited precipitation and surface water has greatly increased the reliance on groundwater irrigation. Further, urban groundwater use has risen exponentially to meet the ever-increasing population growth of mega-cities. These trends have resulted in a dramatic rise in groundwater pumping and associated high rates of aquifer depletion around t",{"id":935,"funder":7,"programme":8,"title":936,"piName":10,"institution":609,"country":257,"year":13,"amount":709,"abstract":937},"cordis-european-research-council-award-885646","Building Arctic Futures: Transport Infrastructures and Sustainable Northern Communities","The new Arctic is attracting global attention for a variety of reasons, including geopolitics, militarisation, resource extraction, wilderness tourism, and calls for environmental protection in the face of rapid climate change. Many of these activities necessitate the construction or upgrading of transport infrastructures in this relatively remote, inaccessible and scarcely-populated part of the world. While these large-scale infrastructures are mostly sponsored by outside interests, they can ha",{"id":939,"funder":7,"programme":8,"title":940,"piName":10,"institution":941,"country":910,"year":13,"amount":74,"abstract":942},"cordis-european-research-council-award-101018688","DNA binding specificity in-vivo","WEIZMANN INSTITUTE OF SCIENCE","How transcription factors (TFs) bind rapidly at specific sites within large genomes remains a major mystery. Specificity is puzzling since TFs select a small fraction of their potential binding sites - short and highly abundant DNA motifs. Rapid detection of these selected sites is challenging due to the small motif size and the large number of non-specific sites within a genome. Despite extensive efforts, a unifying model accounting for these challenges, underlying the foundations of gene regul",{"id":944,"funder":7,"programme":8,"title":945,"piName":10,"institution":572,"country":27,"year":13,"amount":10,"abstract":946},"cordis-european-research-council-award-883551","Virus inhibition of oceanic CO2 fixation","Around half of the carbon dioxide (CO2) fixation on Earth occurs in marine systems, environments dominated by the cyanobacterial genera Synechococcus and Prochlorococcus. Viruses infecting these organisms (cyanophages) divert the flow of an estimated 20% of globally fixed CO2. Intriguingly, my lab has recently shown that cyanophage can directly inhibit host CO2 fixation capacity whilst at the same time carry genes essential for the light-driven reactions of photosynthesis. VirFix will elucidate ",{"id":948,"funder":7,"programme":8,"title":949,"piName":10,"institution":950,"country":393,"year":13,"amount":951,"abstract":952},"cordis-european-research-council-award-101020405","Understanding the Biology of Human Enteroendocrine Cells","F. HOFFMANN-LA ROCHE AG","€2,733,150","Intestinal epithelium consists of self-renewing crypt-villus units and contains 6 mature cell types: Enterocytes, goblet cells, Paneth cells, Tuft cells, M cells and Enteroendocrine cells (EECs). The rare EECs are subclassified by the (>20) hormones they produce. Generally, EECs sense intestinal content and regulate gastrointestinal activity, systemic metabolism and food intake. While one EEC hormone, GLP1, has been developed into a highly successful diabetes drug, a paucity of laboratory models",{"id":954,"funder":7,"programme":8,"title":955,"piName":10,"institution":657,"country":34,"year":13,"amount":956,"abstract":957},"cordis-european-research-council-award-101018280","Contradictory Logics: A Radical Challenge to Logical Orthodoxy","€2,059,026","“The acceptance of contradictions must lead ... to the end of criticism, and thus to the collapse of science.” –  Karl Popper, Conjectures and Refutations.In the 20th century, many systems of non-classical logic have been developed, including inconsistency-tolerant logics, which are typically all subsystems of classical logic. There are, however, logical systems that are radically different from classical logic insofar as they are non-trivial but contradictory. These logics are in glaring confli",{"id":959,"funder":7,"programme":8,"title":960,"piName":10,"institution":961,"country":12,"year":13,"amount":962,"abstract":963},"cordis-european-research-council-award-101021061","A Scientific Approach to Innovation Management","UNIVERSITA COMMERCIALE LUIGI BOCCONI","€1,978,213","There is strong evidence that managers and entrepreneurs have poor methods to make decisions under uncertainty. This is a serious problem that discourages innovation and the success of many start-ups. At the aggregate level it sties economic growth and the returns from many public and private incentives to innovation or entrepreneurship. This project studies whether managers and entrepreneurs can improve their ability to make these decisions by adopting a scientic approach based on the formulati",{"id":965,"funder":7,"programme":8,"title":966,"piName":10,"institution":822,"country":145,"year":13,"amount":967,"abstract":968},"cordis-european-research-council-award-101021496","E Pluribus Unum: Principles and Plasticity of Electrical Coupling in a Neuronal Network","€2,222,161","The complex network activity patterns of the CNS result from an interplay between intrinsic neuronal properties and the connections formed by component cells. Connectivity is most commonly considered in terms of the classical chemical synapse. It is now clear, however, that electrical synapses formed by intercellular connexin channels in gap junctions (GJs) are widespread in the mammalian CNS and critically influence circuit activity. But exactly how GJs shape brain output, and how electrical co",{"id":970,"funder":7,"programme":8,"title":971,"piName":10,"institution":518,"country":238,"year":13,"amount":972,"abstract":973},"cordis-european-research-council-award-885682","Back to the roots of data-driven dynamical system identification","€2,485,925","To obtain data-driven dynamic models for simulation, prediction, monitoring, classification or control tasks, in applications e.g. in Industry 4.0 and eHealth, most identification methods ‘solve’ an optimization problem, relying on some nonlinear iterative algorithm. Undeniably, too many heuristics prevail: What do we mean by ‘solved’?  Where did the algorithm converge to? Is the model globally optimal, unique and reproducible? To tackle these scientific deficiencies, we design a framework to de",{"id":975,"funder":7,"programme":8,"title":976,"piName":10,"institution":244,"country":27,"year":13,"amount":977,"abstract":978},"cordis-european-research-council-award-101021183","Echoes of Vanishing Voices in the Mountains: A Linguistic History of Minorities in the Near East","€1,997,800","Mesopotamia is the home of remarkably diverse ethnoreligious and linguistic microcommunities with historical roots in the ancient Near East. Jewish and Christian minorities with their own unique Ara-maic traditions have co-existed alongside mainly Iranian speech communities for millennia. Today the origin and development of this rich cultural-linguistic mosaic remains elusive due to superimposed nationalisms and paucity of historical records. ALHOME aims to reconstruct the complex, socioreligiou",{"id":980,"funder":7,"programme":8,"title":981,"piName":10,"institution":518,"country":238,"year":13,"amount":982,"abstract":983},"cordis-european-research-council-award-885273","Not another history of Platonism. The role of Aristotle's criticisms of Plato in the development of ancient Platonism","€2,335,911","The conventional historiography of ancient Platonism follows patterns that ultimately go back to Antiquity itself. While these traditional doxographical accounts are not per se inaccurate, they do overlook continuities across different phases of this thousand-year history as well as some unexpected discontinuities. The reason for these shortcomings lies in the fact that certain philosophical debates are being ignored. Some omissions could be detected by searching for the philosophical reasons ex",{"id":985,"funder":7,"programme":8,"title":986,"piName":10,"institution":987,"country":393,"year":13,"amount":988,"abstract":989},"cordis-european-research-council-award-884664","Overcoming chromatin restricted DNA access","FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION","€2,302,500","Differential gene expression programs account for the diversity of cell types in our body. They are controlled by intricate networks of sequence-specific transcription factors (TFs) that operate in the context of chromatin. Chromatin is itself an essential component of this process, and is part of the system that selectively restricts DNA access for TFs. As a consequence, most TFs only bind to a small subset of their motif occurrences, in a way we currently do not fully understand. Our inability",{"id":991,"funder":7,"programme":8,"title":992,"piName":10,"institution":993,"country":34,"year":13,"amount":994,"abstract":995},"cordis-european-research-council-award-101020009","Tame geometry and transcendence in Hodge theory","HUMBOLDT-UNIVERSITAET ZU BERLIN","€1,815,642","Hodge theory, as developed by Deligne and Griffiths, is the main tool for analyzing the geometry and arithmetic of complex algebraic varieties, that is, solution sets of algebraic equations over the complex numbers. It occupies a central position in mathematics through its relations to differential geometry, algebraic geometry, differential equations and number theory. It is an essential fact that at heart, Hodge theory is NOT algebraic. On the other hand, some of the deepest conjectures in math",{"id":997,"funder":7,"programme":8,"title":998,"piName":10,"institution":213,"country":27,"year":13,"amount":999,"abstract":1000},"cordis-european-research-council-award-884598","Business Cycle Causes and Consequences","€1,729,806","Business cycles impact on a large cross-section of the population simultaneously and matters for welfare. Gordon Brown stated in 2002: There will be no return to boom and bust but in 2007\u002F08 the Global Financial Crisis triggered the Great Recession, the deepest recession since the 1930s. Mainstream macro (representative agents, complete markets, competitive\u002Fmonopolistic behavior, full information) was criticized rightly or wrongly for failing to predict the crisis. But the field is now undergoin",{"id":1002,"funder":7,"programme":8,"title":1003,"piName":10,"institution":883,"country":179,"year":13,"amount":1004,"abstract":1005},"cordis-european-research-council-award-101020403","Beyond Sharia:  The Role of Sufism in Shaping Islam","€2,499,625","This project seeks to explain the emergence, flourishing and lasting appeal of non-conformist movements in Islamic intellectual history, investigating how Islamic antinomian movements both consolidated Islam in a vast region from the Balkans to Bengal, while offering methods of self-reflection that allowed for critical thinking within Islamic streams of thought. By examining how generations of Islamic mystics and intellectuals in the Persianate world challenged, redefined or rejected Islamic can",{"id":1007,"funder":7,"programme":8,"title":1008,"piName":10,"institution":1009,"country":257,"year":13,"amount":1010,"abstract":1011},"cordis-european-research-council-award-885479","Dynamics of Molecular Interactions with Ions","UNIVERSITAET INNSBRUCK","€2,488,703","Being able to clarify the atomistic dynamics of molecular collisions and chemical reactions has been a central research goal for decades. For reactions of charged particles in particular, the importance of quantum dynamics is barely understood, as quantum state-resolved experiments beyond total cross section measurement are very challenging and most theoretical descriptions still rely on quasi-classical approaches. In particular, quantum scattering resonances, known by now to be relevant in a fe",{"id":1013,"funder":7,"programme":8,"title":1014,"piName":10,"institution":1015,"country":196,"year":13,"amount":74,"abstract":1016},"cordis-european-research-council-award-101018287","Monte-Carlo Determination of Causation in Turbulence","UNIVERSIDAD POLITECNICA DE MADRID","Simulations have driven many recent scientific advances. In the case of the physics of fluid turbulence, they have involved some of the most expensive computations at any time, but faster computers now permit meaningful simulations to run in minutes in a modest machine. This proposal centres on exploring the role of simulations in this limit of ‘zero’ computing cost, and on the analysis of the resulting data. What ‘free’ simulations allow is ‘Monte-Carlo’ research, in which ideas are ‘randomly’ ",{"id":1018,"funder":7,"programme":8,"title":1019,"piName":10,"institution":26,"country":27,"year":13,"amount":1020,"abstract":1021},"cordis-european-research-council-award-101021207","Predictive computational models for Enzyme Dynamics, Antimicrobial resistance, Catalysis and Thermoadaptation for Evolution and Design","€2,482,332","Enzymes are superlative catalysts, honed by billions of years of evolution to achieve high specificity and efficiency. Understanding how enzymes function and are adapted to different environments will be essential in developing biocatalysts for the circular economy and in combating drug resistance. Basic principles of catalysis and mechanistic understanding have come from experiments and simulations, and significant progress has been made in designing and evolving de novo protein catalysts. Trul",{"id":1023,"funder":7,"programme":8,"title":1024,"piName":10,"institution":1025,"country":20,"year":13,"amount":1026,"abstract":1027},"cordis-european-research-council-award-101018777","The reception of ancient Greece in pre-modern French literature and illustrations of manuscripts and printed books (1320-1550): how invented memories shaped the identity of European communities","UNIVERSITE DE CAEN NORMANDIE","€2,499,202","Until now the reception history of ancient Greece in pre-modern Western Europe has focussed almost exclusively on the transmission of Greek texts. Yet well before the revival of Greek’s teaching, numerous vernacular works, often illustrated, contained elaborate representations of ancient Greece. AGRELITA will study a large corpus of French-language literary works (historical, fictional, poetic, didactic) produced from 1320 to the 1550s in France and Europe, before the first direct translations f",{"id":1029,"funder":7,"programme":8,"title":1030,"piName":10,"institution":321,"country":27,"year":13,"amount":1031,"abstract":1032},"cordis-european-research-council-award-101020503","Evolution in wild populations","€1,818,417","The impact of global environmental change on natural populations is both an urgent concern, and an invaluable opportunity to understand how environmental variation shapes evolutionary and ecological processes. This project will combine state-of-the-art genomic and statistical technology with globally distributed studies to build a ground-breaking new understanding of the evolutionary and ecological dynamics of wild populations. At the same time, it will deliver much-needed application of both lo",{"id":1034,"funder":7,"programme":8,"title":1035,"piName":10,"institution":476,"country":196,"year":13,"amount":1036,"abstract":1037},"cordis-european-research-council-award-101020135","Engineering a lung bacteria to treat idiopatic lung fibrosis and other non-infectious lung diseases","€2,973,296","Lung diseases are a leading cause of mortality worldwide. Dysregulation of immunomodulatory molecules plays a key role in many pulmonary diseases, including lung cancer, idiopathic pulmonary fibrosis (IPF) and infections. In IPF acute or chronic inflammation results in senescence of the alveolar cells with telomere shortening and\u002For dysregulation of miRNAs. Modulating the immune response directly or its downstream repercussions could be a possible way to help treat lung diseases. Systemic treatm",{"id":1039,"funder":7,"programme":8,"title":1040,"piName":10,"institution":244,"country":27,"year":13,"amount":1041,"abstract":1042},"cordis-european-research-council-award-882929","Efficient and Robust Oxide Switching","€1,913,521","We are at the beginning of a Data Age. Data is exploding. In 2016, 90% of the world’s data ever created was in the two previous years.  AI and data analytics are further increasing the growth. The power demand is huge and growing. Within a few years some developed countries will not have sufficient power to sustain the growth. The negative effects on the planet are serious. Non-volatile memory (NVM) technology (including memory and neuromorphic computing elements in a single device) could strong",{"id":1044,"funder":7,"programme":8,"title":1045,"piName":10,"institution":244,"country":27,"year":13,"amount":1046,"abstract":1047},"cordis-european-research-council-award-101020167","Spin Control in Radical Semiconductors","€1,999,812","SCORS will deliver a paradigm change for organic semiconductor science and technology by exploring and developing the electronic and optical properties of radical (spin ½)-based organic semiconductors (ROSCs).  The proposer has recently discovered these can show very efficient photoluminescence and can support efficient organic light emitting diodes (OLED) operation within the spin doublet manifold. SCORS will comprise five key themes:1) Develop and synthesize new structures for ROSCs to control",{"id":1049,"funder":7,"programme":8,"title":1050,"piName":10,"institution":493,"country":34,"year":13,"amount":1051,"abstract":1052},"cordis-european-research-council-award-101018672","molecular and functional characterization of EmergiNG INflammasomES","€2,372,637","Inflammasomes play a pivotal role in host defense. They function as intracellular surveillance systems by sensing pathogens or indirectly by responding to the perturbation of cellular homeostasis. While our understanding of inflammasome biology is growing at a rapid pace, we still have an incomplete understanding of how these systems detect pathogenic insults, or how these sensors operate at the molecular level. Just recently, NLRP1 and the closely related CARD8, a functionally distinct subgroup",{"id":1054,"funder":7,"programme":8,"title":1055,"piName":10,"institution":1056,"country":34,"year":13,"amount":1057,"abstract":1058},"cordis-european-research-council-award-883892","Psychobiological mechanisms of pain persistence","UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF","€2,498,294","Persistent or chronic pain is a key medical and societal problem. In the last decades, biomedical research has undertaken enormous efforts to develop treatments for persistent pain, but the results have been disappointing. This project proposes a radical shift, namely to target the early development of pain persistence and to investigate psychological interventions directed at negative expectations, control and reward in experimental long-term pain studies. A methodological work package will dev",{"id":1060,"funder":7,"programme":8,"title":1061,"piName":10,"institution":544,"country":34,"year":13,"amount":1062,"abstract":1063},"cordis-european-research-council-award-883700","Tracing language and population mixing in the Gansu-Qinghai area","€2,497,850","Chinese history was co-constructed by Han (Chinese) people, transmitters of farming language and culture, and non-Han people, typically transmitters of nomadic language and culture in North and Northwest China. Governance by non-Han steppe rulers lasted for almost ten centuries (half of the history of imperial China since the First Emperor of Qin) and the Gansu-Qinghai area was the most important migration corridor between Central and East Asia. These languages and populations have competed, mix",{"id":1065,"funder":7,"programme":8,"title":1066,"piName":10,"institution":1067,"country":12,"year":13,"amount":1068,"abstract":1069},"cordis-european-research-council-award-882340","A Physics-Informed Machine-Learning Platform for Smart Lagrangian  Harness and Control of TURBulence","UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA","€2,248,875","Where is it difficult to control, predict and model a flowing system? to search and navigate inside it? to be prepared against extreme events? to tame them? It is in turbulent flows.Turbulence is ubiquitous and unsolved from the point of view of out-of-equilibrium fundamental physics, uncontrollable from the engineering aspects, and a deadlock for brute-force numerical and experimental investigations. Indeed, progress by using conventional methods has been slow.In this project, I propose to expl",{"id":1071,"funder":7,"programme":8,"title":1072,"piName":10,"institution":297,"country":34,"year":13,"amount":227,"abstract":1073},"cordis-european-research-council-award-101018682","Mapping Magnetic Fields with INterferometry Down to Event hoRizon Scales","Active galactic nuclei (AGN) are the most extreme sources of radiative and kinetic power in the Universe, often outshining their entire host galaxies. The production and outward transport of the AGN power can be explained involving rotating supermassive black holes, accretion disks, relativistic plasma jets, and magnetic fields. These plasma jets have been imaged on scales from a few light-days up to thousands of light-years using Very Long Baseline Interferometry (VLBI). The Event Horizon Teles",{"id":1075,"funder":7,"programme":8,"title":1076,"piName":10,"institution":263,"country":34,"year":13,"amount":1077,"abstract":1078},"cordis-european-research-council-award-101018890","Visual Scepticism. Towards an Aesthetic of Doubt","€2,369,431","In early summer 2020, numerous monuments around the world were demolished after the death of George Floyd. The iconoclastic acts raise the pressing question of how this historical legacy should be dealt with. In a publication of the same name, Norbert Huse, a conservator of cultural heritage, spoke of uncomfortable monuments in this context. Since monuments of fascism and colonialism in particular also express the inhuman ideology of the regimes aesthetically, the frequently chosen solution of p",{"id":1080,"funder":7,"programme":8,"title":1081,"piName":10,"institution":657,"country":34,"year":13,"amount":1082,"abstract":1083},"cordis-european-research-council-award-101019086","The Making of Monoculture: A Global History","€2,088,200","Monocultures are one of the great projects of industrial modernity. From the corn fields of Iowa to date palms in the Sahara, from banana plantations in the Americas to eucalyptus trees in India – wherever we look, we find large production regimes that focus on a single commodity. They supply the lion’s share of the world’s food and create a plethora of economic, social, political and environmental problems. However, there is a great paradox behind the global hegemony of monocultures: they thriv",{"id":1085,"funder":7,"programme":8,"title":1086,"piName":10,"institution":297,"country":34,"year":13,"amount":1087,"abstract":1088},"cordis-european-research-council-award-101018839","Positivity in Lie groups and representation varieties","€2,028,016","Lie groups lie at the heart of mathematics. They play an important role in geometry, analysis, number theory, algebraic geometry and representation theory. As they describe symmetries of a space or a system they also appear prominently in theoretical physics. Not every system realizes the full amount of symmetry, it is therefore of key importance to investigate not only Lie groups, but also their subgroups, and in particular their discrete subgroups, which are often linked to geometric or arithm",{"id":1090,"funder":7,"programme":8,"title":1091,"piName":10,"institution":244,"country":27,"year":13,"amount":1092,"abstract":1093},"cordis-european-research-council-award-883703","Pico-Photonic Forces at the Atomic Scale","€2,451,402","The key aim of this project is to understand and utilise optically-produced forces on the atomic scale through pico-photonics, in order to devise future nano-mechanisms and nano-machines. Key goals are to move individual metal atoms by light, twist and compress and flip individual molecules on demand, and provide a step-change in the comprehension of how ions, solvent, molecules and electrons interact at interfaces, which is critical in catalysis, molecular electronics, electrochemistry, and nan",{"id":1095,"funder":7,"programme":8,"title":1096,"piName":10,"institution":244,"country":27,"year":13,"amount":1097,"abstract":1098},"cordis-european-research-council-award-101018984","Recognition-encoded synthetic information molecules","€2,499,850","Linear oligomers encoded with a sequence of side-chains that have specific recognition properties are the basis for a range of properties that are the hallmarks of Nature’s nanotechnology: folding, substrate recognition, catalysis, self-assembly, and molecular replication. Nucleic acids are currently unrivalled as the only molecular architecture that embodies all of these properties, and this ability to encode, express and replicate sequence information is the molecular basis for the evolution o",{"id":1100,"funder":7,"programme":8,"title":1101,"piName":10,"institution":297,"country":34,"year":13,"amount":1102,"abstract":1103},"cordis-european-research-council-award-885504","Impact of yolk-cellular blastoderm-egg shell interactions on the evolution of animal gastrulation","€2,371,791","Early animal development, including the process of gastrulation, exhibits tremendous diversity of morphogenetic mechanisms. How does this morphological divergence evolve under the constraints imposed on early embryos remains unclear. In this proposal, I will ask how interactions between cells of the early embryo, the yolk component of the egg and the attachment to the surrounding egg shell affects gastrulation morphogenesis. I will focus on the comparison of two insect embryos, Drosophila and Tr",{"id":1105,"funder":7,"programme":8,"title":1106,"piName":10,"institution":1107,"country":12,"year":13,"amount":1108,"abstract":1109},"cordis-european-research-council-award-884952","Immune-privileged, immortal, myogenic stem cells for gene therapy of Muscular Dystrophy.","OSPEDALE SAN RAFFAELE SRL","€2,345,625","Duchenne muscular dystrophy (DMD) is a devastating incurable disease, affecting thousands with heavy burden on health systems. This project combines the development of a safe, immune-privileged cell with genetic engineering to correct many dystrophin gene mutations for an efficacious and cost affordable therapy. The applicant pioneered systemic intra-arterial transplantation of mesoangioblasts (blood vessel-derived progenitors) that proved safe in DMD patients and is being implemented for effica",200,{"programme":8,"total":1112,"withPiName":1113,"firstYear":1114,"lastYear":1115,"countryCount":1116,"perYear":1117,"topInstitutions":1174,"topCountries":1245},4756,450,2008,2027,46,[1118,1120,1123,1126,1129,1132,1135,1138,1141,1144,1146,1149,1152,1155,1157,1160,1163,1166,1169,1172],{"year":1114,"count":1119},47,{"year":1121,"count":1122},2009,232,{"year":1124,"count":1125},2010,248,{"year":1127,"count":1128},2011,276,{"year":1130,"count":1131},2012,293,{"year":1133,"count":1134},2013,344,{"year":1136,"count":1137},2014,359,{"year":1139,"count":1140},2015,138,{"year":1142,"count":1143},2016,299,{"year":1145,"count":1122},2017,{"year":1147,"count":1148},2018,376,{"year":1150,"count":1151},2019,241,{"year":1153,"count":1154},2020,137,{"year":13,"count":1156},228,{"year":1158,"count":1159},2022,322,{"year":1161,"count":1162},2023,252,{"year":1164,"count":1165},2024,243,{"year":1167,"count":1168},2025,222,{"year":1170,"count":1171},2026,264,{"year":1115,"count":1173},3,[1175,1178,1181,1184,1187,1190,1193,1196,1199,1202,1205,1208,1211,1214,1217,1220,1223,1226,1228,1231,1233,1235,1237,1240,1242],{"name":1176,"count":1177},"Centre National de la Recherche Scientifique CNRS",206,{"name":1179,"count":1180},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",133,{"name":1182,"count":1183},"University of Oxford",128,{"name":1185,"count":1186},"University of Cambridge",124,{"name":1188,"count":1189},"Eidgenoessische Technische Hochschule Zuerich",84,{"name":1191,"count":1192},"Weizmann Institute of Science",74,{"name":1194,"count":1195},"École Polytechnique Fédérale de Lausanne",72,{"name":1197,"count":1198},"University College London",69,{"name":1200,"count":1201},"Ludwig-Maximilians-Universitaet Muenchen",59,{"name":1203,"count":1204},"The Hebrew University of Jerusalem",57,{"name":1206,"count":1207},"Katholieke Universiteit Leuven",52,{"name":1209,"count":1210},"University of Bristol",49,{"name":1212,"count":1213},"University of Edinburgh",48,{"name":1215,"count":1216},"Kobenhavns Universitet",40,{"name":1218,"count":1219},"Universiteit van Amsterdam",39,{"name":1221,"count":1222},"Institut National de la Sante Et de la Recherche Medicale",38,{"name":1224,"count":1225},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",35,{"name":1227,"count":1225},"Tel Aviv University",{"name":1229,"count":1230},"Imperial College of Science Technology and Medicine",33,{"name":1232,"count":1230},"Technische Universitaet Muenchen",{"name":1234,"count":1230},"Universitat Wien",{"name":1236,"count":1230},"University of Manchester",{"name":1238,"count":1239},"Helsingin Yliopisto",32,{"name":1241,"count":1239},"Karolinska Institutet",{"name":1243,"count":1244},"Technische Universiteit Delft",30,[1246,1248,1250,1252,1254,1256,1258,1260,1262,1264,1266,1267,1269,1272,1274,1276,1278,1279,1282,1285,1288,1290,1293,1294,1297],{"name":34,"count":1247},802,{"name":27,"count":1249},778,{"name":20,"count":1251},581,{"name":179,"count":1253},390,{"name":393,"count":1255},310,{"name":12,"count":1257},302,{"name":196,"count":1259},269,{"name":910,"count":1261},202,{"name":145,"count":1263},183,{"name":257,"count":1265},153,{"name":238,"count":1265},{"name":173,"count":1268},107,{"name":1270,"count":1271},"GB",78,{"name":220,"count":1273},76,{"name":777,"count":1275},65,{"name":162,"count":1277},42,{"name":138,"count":1216},{"name":1280,"count":1281},"HU",25,{"name":1283,"count":1284},"EL",24,{"name":1286,"count":1287},"US",20,{"name":770,"count":1289},18,{"name":1291,"count":1292},"CZ",15,{"name":41,"count":1292},{"name":1295,"count":1296},"CN",9,{"name":1298,"count":1299},"EE",8]