[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-advanced-grant-2023":3,"awarded-stats-erc-advanced-grant":1106},{"awarded":4,"total":1105},[5,16,23,29,36,43,50,57,63,69,75,81,87,92,98,104,109,115,122,128,134,140,145,149,154,160,167,172,179,184,188,194,200,206,211,216,221,226,231,238,245,251,256,262,266,272,277,283,289,294,298,305,311,317,322,328,333,338,344,349,355,360,366,372,377,383,389,394,400,406,411,415,420,424,429,434,440,446,452,456,461,466,472,477,482,487,493,498,503,509,515,519,524,529,535,540,546,552,558,563,568,574,580,586,592,598,602,607,613,618,624,629,634,640,646,652,658,664,668,672,678,682,688,692,698,703,709,715,721,727,732,738,743,749,755,761,766,770,774,779,784,790,795,801,806,811,816,823,828,832,838,844,849,854,859,865,870,875,880,886,891,896,901,906,911,915,921,926,932,938,942,948,953,957,962,968,973,979,986,991,996,1002,1007,1014,1019,1023,1029,1034,1039,1044,1050,1055,1060,1066,1071,1077,1082,1088,1093,1099],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-101054467","European Research Council","ERC Advanced Grant","Solving the dynamic range problem of hearing: deciphering and harnessing cochlear mechanisms of sound intensity coding",null,"UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS","DE",2023,"€2,499,411","Our sense of hearing processes stimuli that differ in sound pressure by more than six orders of magnitude. Yet, while the presynaptic inner hair cells (IHCs) cover this wide dynamic range, each postsynaptic spiral ganglion neuron (SGN) encodes only a fraction and the intensity information is then reconstructed by the brain. This so-called “dynamic range problem” of hearing is known for decades, but how sound intensity information is decomposed into different neural pathways remains elusive.In vi",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":20,"year":13,"amount":21,"abstract":22},"cordis-european-research-council-award-101055060","Are you experienced? An exploration into the functions and value of consciousness","UNIVERSITE LIBRE DE BRUXELLES","BE","€2,303,531","Why would we do anything at all if the doing was not doing something to us? In other words: What is consciousness good for? Here, reversing classical views according to which subjective experience is a mere epiphenomenon that affords no functional advantage, I propose that the core function of phenomenal experience is to enable subject-level valuation: What it feels like is endowed with intrinsic value. Thus, I argue that it is only in virtue of the fact that conscious agents experience things a",{"id":24,"funder":7,"programme":8,"title":25,"piName":10,"institution":26,"country":12,"year":13,"amount":27,"abstract":28},"cordis-european-research-council-award-101055377","Local and systemic mechanisms for metabolic inflammation chronicity","TECHNISCHE UNIVERSITAET DRESDEN","€2,493,275","Chronic inflammation underlies several diseases and is a common basis of multiple comorbidities. In obesity, chronic inflammation of the adipose tissue (AT) and liver contributes to the metabolic syndrome and related metabolic-inflammatory pathologies. Here, we propose a thorough and innovative approach to revolutionize understanding of metabolic inflammation chronicity. We will address both local (at the respective tissue level) and systemic mechanisms, involving the novel principle of trained ",{"id":30,"funder":7,"programme":8,"title":31,"piName":10,"institution":32,"country":33,"year":13,"amount":34,"abstract":35},"cordis-european-research-council-award-101054963","Cold War Europe Beyond Borders. A Transnational History of Cross-Border Practices in the Alps-Adriatic area from World War II to the present.","ZNANSTVENO-RAZISKOVALNO SREDISCE KOPER","SI","€2,474,330","This project aims to rethink the history of Cold War Europe by examining the development of transnational cross-border cooperation from the end of World War II to the present. Overcoming traditional narratives of a clear-cut European separation symbolised by the Berlin Wall, a decentralised analysis of recent European history will show us that the question of a divided continent should be reframed. The final objective is to challenge a dichotomous vision of two separate Europes, “East” and “West",{"id":37,"funder":7,"programme":8,"title":38,"piName":10,"institution":39,"country":40,"year":13,"amount":41,"abstract":42},"cordis-european-research-council-award-101054532","Balancing brain chemicals for boosting meta-control","STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM","NL","€2,625,000","Cognitive control enables us to flexibly adapt behaviour to achieve our goals given a constantly changing environment. It is a hallmark of the human mind and exquisitely vulnerable in health and disease. Cognitive control often implies goal-directed instrumental effort to inhibit unwanted, yet hardwired or overlearnt biases, and is commonly associated with the prefrontal cortex (PFC) and dopamine (DA). However, the mechanisms of the broader construct of flexible cognitive control remain unclear.",{"id":44,"funder":7,"programme":8,"title":45,"piName":10,"institution":46,"country":47,"year":13,"amount":48,"abstract":49},"cordis-european-research-council-award-101053472","Noise in Fluids","SCUOLA NORMALE SUPERIORE","IT","€1,785,875","Fluids, in complex regimes, show random features. The aim of this project is approaching several questions around the randomness of fluids by means of a theory that could be called “Stochastic Fluid Mechanics”. The distinctive feature of this theory, opposite to others that investigated the stochastic features of fluids, is that it is based on the usual continuum mechanics equations, in particular the Navier-Stokes and Euler equations, but suitably modified by the presence of random elements, li",{"id":51,"funder":7,"programme":8,"title":52,"piName":10,"institution":53,"country":54,"year":13,"amount":55,"abstract":56},"cordis-european-research-council-award-101054936","Effective Random Methods in Discrete Mathematics","HUN-REN RENYI ALFRED MATEMATIKAI KUTATOINTEZET","HU","€2,019,035","The probabilistic method, pioneered by Paul Erdős, can show the existence of combinatorial objects without hinting how to construct them effectively. Recent developments concerning the constructive version of Lovász Local Lemma (LLL) showed how to modify the  probabilistic method to make it effective. This proposal lists four research directions in analysis, combinatorics, and cryptography, where this method opened new possibilities to go beyond our present knowledge.1. The measurable version of",{"id":58,"funder":7,"programme":8,"title":59,"piName":10,"institution":60,"country":33,"year":13,"amount":61,"abstract":62},"cordis-european-research-council-award-101053085","Holomorphic Partial Differential Relations","UNIVERZA V LJUBLJANI","€1,476,375","The aim is to develop an emerging field of complex analysis and geometry focused on holomorphic partial differential relations (HPDR). Such a relation of order r is given by a subset of the manifold of r-jets of holomorphic maps between a pair of complex manifolds, and the main question is when does a formal solution lead to an honest analytic solution. This complex analogue of Gromov’s h-principle is highly important but poorly understood. The project will focus on the following problems.(A) Ok",{"id":64,"funder":7,"programme":8,"title":65,"piName":10,"institution":66,"country":12,"year":13,"amount":67,"abstract":68},"cordis-european-research-council-award-101052786","Order at the Mesoscale: Connecting supercomputing of compressible convection to classical and quantum machine learning","TECHNISCHE UNIVERSITAET ILMENAU","€2,500,000","Turbulent convection flows in nature display prominent patterns in the mesoscale range whose characteristic length in the horizontal directions exceeds the system scale height. Known as the turbulent superstructure of convection, they are absent on both larger and smaller scales and evolve in ways not yet understood; but they are an essential link in the heat and momentum transport to larger scales, an important driver of intermittent fluid motion at sub-mesoscales, and one major source of uncer",{"id":70,"funder":7,"programme":8,"title":71,"piName":10,"institution":72,"country":47,"year":13,"amount":73,"abstract":74},"cordis-european-research-council-award-101055295","Information Economics for Science","UNIVERSITA COMMERCIALE LUIGI BOCCONI","€1,461,050","Given the uncertainty shrouding even the most promising research projects, information plays a key role in the organization of science. The project develops foundational tools in the organizational economics oGiven the uncertainty shrouding even the most promising research projects, information plays a key role in the organization of science. The project develops foundational tools in the organizational economics of science, through two inter-linked packages: I. Comparing InformationResearchers ",{"id":76,"funder":7,"programme":8,"title":77,"piName":10,"institution":78,"country":12,"year":13,"amount":79,"abstract":80},"cordis-european-research-council-award-101053194","The actuation of sound change","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€2,468,550","In William Shakespeare's times, 'knee' and 'knot' were pronounced with a \u002Fk\u002F, just like German does today. But why did English and not German drop the \u002Fk\u002F? This question is part of the actuation of sound change, recognised as one of the greatest challenges in linguistics, and which is about explaining why sound change happens, and why languages can follow such different paths of sound change. The actuation puzzle remains unsolved principally because the beginning of sound change is so gradual th",{"id":82,"funder":7,"programme":8,"title":83,"piName":10,"institution":84,"country":85,"year":13,"amount":67,"abstract":86},"cordis-european-research-council-award-101054745","Three Generations of Digital Human Rights","THE HEBREW UNIVERSITY OF JERUSALEM","IL","The proposed research program explores different strategies developed in the digital age within and outside international human rights law to respond to new needs, interests, risks and challenges brought about by transition of inter-personal interactions, social activities and regulatory schemes from offline to online environments. It investigates the development in recent years of three generations of digital human rights: adaptation of existing rights and their manner of application to online ",{"id":88,"funder":7,"programme":8,"title":89,"piName":10,"institution":26,"country":12,"year":13,"amount":90,"abstract":91},"cordis-european-research-council-award-101054940","Ultracapacitor Logic Gates","€2,351,250","Ultracapacitors (also referred to as Supercapacitors or ElectricUltracapacitors (also referred to as Supercapacitors or Electric Double Layer Capacitors, EDLCs) stand out as high power devices for ultrafast energy storage. A new paradigm is to use ion electroadsorption devices for logic information processing. In living organisms, ions and chemical transmitters are involved in signaling, managing logic operations and memory, evolutionary optimized in terms of energy-efficiency. My group recently",{"id":93,"funder":7,"programme":8,"title":94,"piName":10,"institution":95,"country":96,"year":13,"amount":67,"abstract":97},"cordis-european-research-council-award-101052761","Dispersals, resilience, and innovation in  Late Pleistocene SE Africa","UNIVERSIDADE DO ALGARVE","PT","Genetic evidence suggests that successful modern human migration out of Africa is believed to have started c. 70,000 years ago, populating the whole world, at different rates and times. This incredible voyage took place because of humans unique resilience, versatility, and innovation, both biological and cultural, to external stimuli, including ecological and environmental changes. The main objective of DISPERSALS is to investigate the migration and dispersal dynamics of early Homo sapiens in Af",{"id":99,"funder":7,"programme":8,"title":100,"piName":10,"institution":101,"country":85,"year":13,"amount":102,"abstract":103},"cordis-european-research-council-award-101054948","Cellular models for tissue function in development and ageing","WEIZMANN INSTITUTE OF SCIENCE","€2,937,179","One of the most fundamental challenges in contemporary biology is in fact also one of the most classical ones: how to comprehend macroscopic tissue function from the activities of its microscopic cellular components. The remarkable advent of single cell genomics over the last decade is realizing this challenge at unprecedented scales. Measurements of the molecular states of thousands or even millions of cells can now be acquired efficiently, and tools for describing cellular states phenomenologi",{"id":105,"funder":7,"programme":8,"title":106,"piName":10,"institution":107,"country":40,"year":13,"amount":67,"abstract":108},"cordis-european-research-council-award-101052963","NeUronal MEchanisms foR consciOUS perception","KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW","Understanding the mechanisms for consciousness is arguably one of the most intriguing questions of modern neuroscience. Why are some visual stimuli consciously perceived, whereas others remain subliminal? What is the relation between conscious perception, attention and working memory? Recent work of my lab demonstrated that weak but simple stimuli can be reported once they elicit a minimal level of activity in the frontal cortex, which is related to the storage of the stimulus in working memory.",{"id":110,"funder":7,"programme":8,"title":111,"piName":10,"institution":112,"country":47,"year":13,"amount":113,"abstract":114},"cordis-european-research-council-award-101054098","ANalogue In-Memory computing with Advanced device TEchnology","POLITECNICO DI MILANO","€2,498,868","Every day we generate, process and use a massive amount of data. Searching a keyword on the internet, choosing a movie for the weekend and booking our next holiday are just a few simple actions that rely on data-intensive algorithms in the cloud, such as data search, recommendation and page ranking. The energy cost of computation is high: it has been recently reported that training a relatively large neural network produces the same carbon dioxide of 5 cars in their whole lifetime. Data centres ",{"id":116,"funder":7,"programme":8,"title":117,"piName":10,"institution":118,"country":119,"year":13,"amount":120,"abstract":121},"cordis-european-research-council-award-101053716","Towards On-Chip Plasmonic Amplifiers of THz Radiation","INSTYTUT WYSOKICH CISNIEN POLSKIEJ AKADEMII NAUK","PL","€2,499,999","Thirty years ago Dyakonov and Shur opened a new field in solid-state physics and electronics - plasma-wave electronics. They theoretically predicted that: i) in nano-transistors, plasma waves may oscillate at THz frequencies far beyond the devices’ cut-off GHz frequencies, ii) THz radiation can be detected by plasma nonlinearities, and iii) the current flow can lead to the generation of THz radiation. The detection part of the “plasmonics promise” was proven and nowadays THz plasmonic detector a",{"id":123,"funder":7,"programme":8,"title":124,"piName":10,"institution":125,"country":40,"year":13,"amount":126,"abstract":127},"cordis-european-research-council-award-101055397","Building a Global Criminal Justice System at the Domestic Level","TILBURG UNIVERSITY- UNIVERSITEIT VAN TILBURG","€2,332,184","JOINEDUPJUSTICE develops parameters for a coordinated system of global justice at the domestic level. While the projects focus is on international criminal law (ICL), international refugee law (IRL) is the starting point; it is the metaphorical canary in the coal mine that flags up questions at the heart of ICL.Many of the domestic prosecutions of international crimes (crimes against humanity, war crimes, genocide) are asylum related. This comes with problems. First, article 1F(a) of the Refugee",{"id":129,"funder":7,"programme":8,"title":130,"piName":10,"institution":131,"country":132,"year":13,"amount":67,"abstract":133},"cordis-european-research-council-award-101053091","Descending control of pain","KAROLINSKA INSTITUTET","SE","Pain is a large societal and health problem. Although often thought of as an invariant representation of active nociceptors, pain varies a lot under the influence of different affective states, sometimes with near complete analgesia. Such modulation of pain is thought to occur through a descending pathway originating in the brain and to be executed by Rostral Ventromedial Medulla (RVM) neurons that project to the spinal cord. Deciphering the complexity of the cell types involved and how they con",{"id":135,"funder":7,"programme":8,"title":136,"piName":10,"institution":137,"country":20,"year":13,"amount":138,"abstract":139},"cordis-european-research-council-award-101054338","Chemistry under Force","UNIVERSITE DE LIEGE","€2,496,838","During the last three decades, physicists and biophysicists have largely exploited single-molecule force spectroscopy (SMFS) to advance many fields of physics, nanotechnology, and biology. The ability to probe one molecule at a time allows us to ask and answer questions that are impossible, or extremely difficult, to approach by ensemble techniques.Chemists did not fall into steps behind physicists and biologists and have benefited little from the advent of SMFS. The mechanics of bonds, which is",{"id":141,"funder":7,"programme":8,"title":142,"piName":10,"institution":143,"country":20,"year":13,"amount":67,"abstract":144},"cordis-european-research-council-award-101054387","Decoding animal genomes into cell types","VIB VZW","The genome of an animal encodes a large set of regulatory programs that give rise to the thousands of cell types that make up its tissues and organs. Despite recent progress in single-cell omics, our knowledge about the regulatory programs that control the establishment and maintenance of cell type identity remains limited, and methods are lacking to infer regulatory programs directly from the genome sequence. In this project, which lies at the interface between the genome and single-cell atlase",{"id":146,"funder":7,"programme":8,"title":147,"piName":10,"institution":78,"country":12,"year":13,"amount":67,"abstract":148},"cordis-european-research-council-award-101054289","Aromatic Foldamer Mimics of B-DNA: Targeting the Alpha-Helix","Protein-nucleic acid interactions (PNIs) play a central role in biology and their control would enable long-desired biological interventions and future therapeutic applications. However, synthetic molecules that reproduce the overall shape and surface features of nucleic acids to interfere with PNIs have been lacking because, up to now, it has not been possible to design such extended and complex abiotic interactions interfaces. Due to their distinct chemical composition, predictable shapes, lar",{"id":150,"funder":7,"programme":8,"title":151,"piName":10,"institution":112,"country":47,"year":13,"amount":152,"abstract":153},"cordis-european-research-council-award-101053309","New Adaptive and BUCkling-driven  COmposite aerospace structures","€2,342,038","The NABUCCO project aims to develop radically new concepts of adaptive and buckling-driven composite structures for next generation aircraft. In aeronautics, buckling is generally avoided because it causes stiffness reduction, large deformations, and can result in a catastrophic collapse. Instead, NABUCCO considers buckling no longer as a phenomenon to be avoided, but as a design opportunity to be explored for its ground-breaking potentialities. The idea is to use buckling drawbacks in a positiv",{"id":155,"funder":7,"programme":8,"title":156,"piName":10,"institution":157,"country":12,"year":13,"amount":158,"abstract":159},"cordis-european-research-council-award-101054515","Lattice determination of the muon's anomalous magnetic moment","FORSCHUNGSZENTRUM JULICH GMBH","€2,085,625","On 4\u002F7\u002F2021 the Fermilab announced the result of a two decade long investigation to determine the magnetic moment of the muon. By tradition, data-driven theoretical methods have been used for 50 years to calculate this magnetic moment. But, interestingly, in the last 20 years growing discrepancies were noted between theoretical and experimental findings. In the literature, the result obtained by using  the data-driven method is called the consensus value - and it is 4.2 sigma away from the combi",{"id":161,"funder":7,"programme":8,"title":162,"piName":10,"institution":163,"country":164,"year":13,"amount":165,"abstract":166},"cordis-european-research-council-award-101054580","Innovation Residues – Modes and infrastructures of caring for our longue-durée environmental futures","UNIVERSITAT WIEN","AT","€2,497,210","Innovation residues designate those left-behinds of innovations that profoundly shape human lives as they stay with us for a long timewell beyond moments of production and consumption, and well beyond the time horizons considered when assessing the worth of innovations. Residues are material witnesses to culture and practice of innovation, to diverse politics at work, and to the limited attention to long-term sustainable futures in a world predominantly shaped by short-term impact thinking. Toda",{"id":168,"funder":7,"programme":8,"title":169,"piName":10,"institution":143,"country":20,"year":13,"amount":170,"abstract":171},"cordis-european-research-council-award-101055155","Endothelial immunosuppressive mystery genes for alternative immunotherapy: artificial intelligence-driven target discovery and lipid nanoparticle\u002FRNA-based target validation","€3,498,426","Compared to my previous Advanced ERC grants, this proposal is fundamentally different not only concerning its topic but also regarding its ambition to offer greater societal impact by coupling knowledge gain tighter to translation. It promises to obtain new insights in an understudied endothelial cell (EC) subtype with immunomodulatory gene signatures (coined IMECs), highly relevant for alternative immunotherapy development. Indeed, silencing immunosuppressive genes in IMECs offers unprece-dente",{"id":173,"funder":7,"programme":8,"title":174,"piName":10,"institution":175,"country":176,"year":13,"amount":177,"abstract":178},"cordis-european-research-council-award-101052360","Literary Translations at War: Mapping World War 2 in Europe (1939-45)","NANTES UNIVERSITE","FR","€2,128,708","While the history of translation is a field in Humanities that has known a significant increase recently worldwide, a European history of literary translation during the war has yet to be written. Due to the importance of power relations, ideology, censorship and propaganda, the practice of literary translation and European translators in wartime is a particularly interesting configuration, but it remained relatively unexplored so far on a truly European level: few comprehensive researches have ",{"id":180,"funder":7,"programme":8,"title":181,"piName":10,"institution":182,"country":85,"year":13,"amount":67,"abstract":183},"cordis-european-research-council-award-101055276","Microbiome centered prediction and prevention of recurrent infections","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","Antibiotics are a double-edged sword: they help clear the current infection, yet can also select for resistant pathogens, making future infections harder to treat. While treatment guidelines recognize this collateral damage, we currently lack strategies to predict how treatments affect future recurrence and resistance at the individual patient level. This problem is of particular importance in Urinary Tract Infections (UTIs); affecting the majority of women over their lifetime, UTIs can chronica",{"id":185,"funder":7,"programme":8,"title":186,"piName":10,"institution":143,"country":20,"year":13,"amount":67,"abstract":187},"cordis-european-research-council-award-101054310","Synaptic resilience in Tau-induced neurodegeneration","Dementia is an enormous burden on society. Patients require life-long care and there is no cure or symptomatic treatment. At early phases, dementia is closely associated with synaptic degeneration and this correlates well with Tau pathology in >20 Tauopathies. Interestingly, historic observations in hamsters and squirrels show that when they enter into hibernation, they also display Tau pathology and synaptic loss. Pathologists have pointed to these similarities; however, there is an important d",{"id":189,"funder":7,"programme":8,"title":190,"piName":10,"institution":191,"country":12,"year":13,"amount":192,"abstract":193},"cordis-european-research-council-award-101055454","Quantum Sensing with van der Waals Heterostructures based on hexagonal Boron Nitride","JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG","€2,499,826","The project idea is to implement a new quantum probe based on hexagonal boron nitride (hBN) containing spin defects to study the properties of artificially stacked two-dimensional (2D) materials and devices. The essential building blocks of such van der Waals (vdW) heterostructures are the quantum defects in hBN recently discovered by the PI and his team. These intrinsic lattice defects - negatively charged boron vacancies VB - can be optically spin-polarized and coherently manipulated, allowing",{"id":195,"funder":7,"programme":8,"title":196,"piName":10,"institution":197,"country":20,"year":13,"amount":198,"abstract":199},"cordis-european-research-council-award-101052649","Beauty and Inequality: Physical Appearance, Symbolic Boundaries and Social Dis\u002Fadvantage in Five Global Cities","KATHOLIEKE UNIVERSITEIT LEUVEN","€2,499,333","How does physical beauty contribute to social inequality? This innovative multi-disciplinary comparative project aims to build a comprehensive new theory that explains how evaluations of physical appearance work, and how they re\u002Fproduce durable inequalities in today’s media-saturated, service-based consumer societies. It hypothesizes that 1. in contemporary societies beauty is an important form of capital for all genders over the life-course; 2. beauty as a form of capital intersects with existi",{"id":201,"funder":7,"programme":8,"title":202,"piName":10,"institution":203,"country":12,"year":13,"amount":204,"abstract":205},"cordis-european-research-council-award-101052785","Configurational Mechanics of Soft Materials: Revolutionising  Geometrically Nonlinear Fracture","FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG","€2,494,538","SoftFrac will revolutionise geometrically nonlinear fracture mechanics of soft materials (in short soft fracture) by capitalising on configurational mechanics, an unconventional continuum formulation that I helped shaping over the past decades. Mastering soft fracture will result in disruptive progress in designing the failure resilience of soft devices, i.e. soft robotics, stretchable electronics and tissue engineering applications. Soft materials are challenging since they can display moduli a",{"id":207,"funder":7,"programme":8,"title":208,"piName":10,"institution":163,"country":164,"year":13,"amount":209,"abstract":210},"cordis-european-research-council-award-101053242","Global Resettlement Regimes: Ambivalent Lessons learned from the Postwar (1945-1951)","€2,159,469","This project argues that the late 1940s and 1950s saw the construction of global resettlement regimes. Earlier scholarship on displacement and resettlement has generally treated post-war experiences in Europe and in Asia as separate domains. In contrast, this project shows the connections between the European and the Asian spheres, and further links them to Australia and the Americas. This project explores the potential of global history with an innovative interface to legal history, by (a) anal",{"id":212,"funder":7,"programme":8,"title":213,"piName":10,"institution":163,"country":164,"year":13,"amount":214,"abstract":215},"cordis-european-research-council-award-101055318","The 3D motion of the Interstellar Medium  with ESO and ESA telescopes","€1,919,306","The current model for the structure of the local Milky Way is in crisis. Data from the ESA Gaia mission has overthrown the 150-year-old paradigm for the gas distribution in the local Milky Way, a 500 pc ring known as Gould’s Belt. In the newly emerging view, local star-forming regions are connected by lower-density gas. They are part of a new organizational unit: undulating, coherent, and linear Galactic-scale gas structures. What is the origin of these kpc-long structures, how do star-forming r",{"id":217,"funder":7,"programme":8,"title":218,"piName":10,"institution":163,"country":164,"year":13,"amount":219,"abstract":220},"cordis-european-research-council-award-101055073","Digital Hate: Perpetrators, Audiences, and (Dis)Empowered Targets","€2,499,591","The skyrocketing rise of digital hate can be considered the dark side of the democratizing power of the internet. Despite growing interest in the topic, there has never been a systematic investigation about the perpetrators, audiences, and targets of digital hate. To discover why digital hate emerges, why it is often tolerated, and what kind of effects it has, DIGIHATE will analyze the reasons, perceptions, and consequences of digital hate for all involved actors. In particular, DIGIHATE will ca",{"id":222,"funder":7,"programme":8,"title":223,"piName":10,"institution":224,"country":176,"year":13,"amount":67,"abstract":225},"cordis-european-research-council-award-101052444","Immunogenic cell death (ICD) in the cancer-immune dialogue","UNIVERSITE PARIS CITE","The success of most if not all anticancer treatments depends on the (re)activation of immunosurveillance, as this has been documented for several therapeutic modalities, not only immunotherapy, but also chemotherapy, targeted therapy and radiotherapy. In response to antineoplastic drugs, malignant cells can undergo immunogenic cell death (ICD), thus exposing and releasing danger signals that act on pattern recognition receptors expressed by immune cells, in particular dendritic cells (DCs), to t",{"id":227,"funder":7,"programme":8,"title":228,"piName":10,"institution":163,"country":164,"year":13,"amount":229,"abstract":230},"cordis-european-research-council-award-101054527","Mechanisms and Functions of Brain- Body- Environment Interactions in C. elegans","€3,500,000","Recent large-scaRecent large-scale neuronal activity recordings in awake, behaving animals revealed a new, unexpected neuroscientific principle: widespread neuronal activity patterns across the brain encode parameters of movement. Surprisingly, these brain-wide behavior representations even extend to areas that are implicated in the processing of sensory information (e.g., the visual cortex in mice). Thus, a large fraction of the brains activity seems to be dedicated to representing the animals ",{"id":232,"funder":7,"programme":8,"title":233,"piName":10,"institution":234,"country":235,"year":13,"amount":236,"abstract":237},"cordis-european-research-council-award-101052376","Analysis of Biofilm Solid Interactions Underpinning Wastewater Treatment","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","IE","€2,496,268","Wastewater treatment (WWT) processes that use biofilms as their biocatalyst have been in use for over 100 years. Over the past few decades, a greater understanding has emerged on how biofilms can be exploited for enhanced nutrient removal and this knowledge has been translated into new technologies representing about one-third of all WWT processes in a multibillion-euro global wastewater technology market.Despite the success of these technologies, there is significant need for enhanced efficienc",{"id":239,"funder":7,"programme":8,"title":240,"piName":10,"institution":241,"country":242,"year":13,"amount":243,"abstract":244},"cordis-european-research-council-award-101054237","Global Value Chain Law: Constituting Connectivity, Contracts and Corporations","COPENHAGEN BUSINESS SCHOOL","DK","€2,055,441","Ongoing struggles over vaccine supplies forcefully illustrates the extent to which Global Value Chains (GVCs) serves as central infrastructures of the global economy and global society. While the COVID-19 pandemic might have been a revelation in this respect, the centrality of GVCs dates back to the dawn of colonialism. Both historically and in contemporary times, GVCs produces profound environmental and socio-economic externalities in jurisdictions often incapable of or unwilling to effectively",{"id":246,"funder":7,"programme":8,"title":247,"piName":10,"institution":248,"country":40,"year":13,"amount":249,"abstract":250},"cordis-european-research-council-award-101055218","Vital Elements and Postcolonial Moves: Forensics as the Art of Paying Attention in a Mediterranean Harbour Town","UNIVERSITEIT VAN AMSTERDAM","€2,499,734","For more than a decade, the dead bodies of people who had hoped to cross the Mediterranean have been washing ashore on the beaches of Zarzis, a coastal town in southern Tunisia. This research program starts out from the question: How did these bodies end up here?While in Europe people who are adrift may be seen as evidence of a migration crisis, from the African side of the Mediterranean they point to the chronic, (neo-)colonial depletion of livelihoods. To map how life is enduringly made unlive",{"id":252,"funder":7,"programme":8,"title":253,"piName":10,"institution":248,"country":40,"year":13,"amount":254,"abstract":255},"cordis-european-research-council-award-101053880","Beyond the tipping point: Cascading transitions in the behavioral and social sciences","€2,493,576","Tipping points or phase transitions separate stable states in psycho-social systems. Examples are quitting smoking, radicalization, and dropping-out of school. Two knowledge gaps prevent our ability to predict and control these tipping points. First, we miss explanatory mathematical models of such non-linear processes. Second, we ignore the multilevel character of psycho-social transitions. I contend that important changes in many psycho-social systems are cascading transitions, where individual",{"id":257,"funder":7,"programme":8,"title":258,"piName":10,"institution":259,"country":242,"year":13,"amount":260,"abstract":261},"cordis-european-research-council-award-101055224","Scalable quantum computing with continuous variable cluster states","DANMARKS TEKNISKE UNIVERSITET","€2,792,416","Measurement-based quantum computation is a highly promising approach to quantum computing as it simply performs quantum processing directly through the measurements of a multi-partite entangled cluster state and thereby circumvents the complex unitary dynamics of conventional gate-based quantum computers. However, despite significant progress over the last decade in devising new strategies for measurement-based quantum computing, significant conceptual and technical challenges still remain for r",{"id":263,"funder":7,"programme":8,"title":264,"piName":10,"institution":259,"country":242,"year":13,"amount":10,"abstract":265},"cordis-european-research-council-award-101054572","Next Generation of Artificial Heterointerfaces as Building Blocks for Energy Materials","In an era of rapid green transition changes, interfaces lie at the heart of the advances in most energy conversion and storage technologies, including batteries, Power-to-X and electrolysis. Depending on the type of device, these technologies rely upon the fast transport of atomic and electronic species across the solid-solid, solid-liquid and solid-gas interfaces. Developing viable solid-state devices requires a fundamental understanding of how ions move at the interface between two solid mater",{"id":267,"funder":7,"programme":8,"title":268,"piName":10,"institution":269,"country":12,"year":13,"amount":270,"abstract":271},"cordis-european-research-council-award-101054823","Beyond nucleocytoplasmic transport – Nuclear pores as self-regulating valves for flux across the nuclear envelope","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€2,117,500","Nuclear pore complexes (NPCs) are fundamental components of all eukaryotic cells. They fuse the inner and outer nuclear membranes and form channels across the nuclear envelope. Their canonical function as gatekeepers of the nucleus and facilitators of nucleocytoplasmic exchange is well established. I hypothesize that NPCs fulfil yet another fundamental function as self-regulating valves for flux across the nuclear envelope that occurs in response to mechanical stress. This yet underappreciated f",{"id":273,"funder":7,"programme":8,"title":274,"piName":10,"institution":269,"country":12,"year":13,"amount":275,"abstract":276},"cordis-european-research-council-award-101054731","Hunting Dormant Black Holes in the Galaxy with SDSS-V","€2,855,000","Stellar evolution models suggest that there ought to be ~10e7 stellar-mass black holes (BHs) in our Milky Way.  However, we currently know only of ~20 BHs, and those are in binaries where accretion makes them shine in X-rays.  Beyond that, no non-accreting ‘dormant’ BH has ever been robustly identified across the Galactic disk.   Finding dormant BHs in binaries (dBHBs) is fundamental to learning when which BHs form, how massive stars die,  and what the precursors of BH gravitational wave events ",{"id":278,"funder":7,"programme":8,"title":279,"piName":10,"institution":280,"country":12,"year":13,"amount":281,"abstract":282},"cordis-european-research-council-award-101055213","Endoplasmic reticulum remodelling via ER-phagy pathways","JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN","€2,496,691","The endoplasmic reticulum (ER) is the most extensive endomembrane system of the cell that undergoes continuous remodelling and adaptation to fulfil required functions in synthesis and transport of cellular components. A major driver of ER remodelling is ER-phagy, a selective autophagy pathway that targets excess or damaged portions of ER for degradation. By linking the ER membrane to the autophagic machinery, ER-phagy receptors play central roles in this process. However, beyond the identities o",{"id":284,"funder":7,"programme":8,"title":285,"piName":10,"institution":286,"country":12,"year":13,"amount":287,"abstract":288},"cordis-european-research-council-award-101054336","Automorphic Forms and Arithmetic","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","€1,956,665","This proposal is at the interface of number theory and automorphic forms and aims at a cross-fertilization of both areas. It focuses on explicit arithmetic problems that can be solved using the full force of the automorphic machinery. Conversely it develops the theory of automorphic forms in higher rank using number theoretic methods.At the core are three sets of deep and longstanding open conjectures in higher rank cases:-  the joint equidistribution conjectures of Michel and Venkatesh concerni",{"id":290,"funder":7,"programme":8,"title":291,"piName":10,"institution":292,"country":47,"year":13,"amount":10,"abstract":293},"cordis-european-research-council-award-101053836","Solidarities and migrants' routes across Europe at large","UNIVERSITA DEGLI STUDI DI GENOVA","Unauthorized migration has always been a contentious issue in the EU. Yet, many of the policies adopted thus far have proved ineffective in containing arrivals and blocking circulations of migrants and refugees within the EU. Furthermore, unauthorized migration has continued to challenge EU borders even during the pandemic.SOLROUTES’ core research question is: how can the turbulence, persistence, and intensity of unauthorized movements and of the production of migrants’ routes across “Europe at ",{"id":295,"funder":7,"programme":8,"title":296,"piName":10,"institution":234,"country":235,"year":13,"amount":10,"abstract":297},"cordis-european-research-council-award-101055195","Animals and Society in Bronze Age Europe","This project will create a new vision of Bronze Age ontologies by exploring the role of animals as active participants in Bronze Age social worlds. The impact of contemporary Capitalist ideology on archaeological understanding of the European Bronze Age has been profound. Dominant narratives describe a world in which economic intensification, the accumulation of wealth and the emergence of chiefly hierarchies were predicated on the objectification of the ‘other’. This project will critically re-",{"id":299,"funder":7,"programme":8,"title":300,"piName":10,"institution":301,"country":302,"year":13,"amount":303,"abstract":304},"cordis-european-research-council-award-101054687","Voltage-Reconfigurable Magnetic Invisibility: A New Concept for Data Security Based on Engineered Magnetoelectric Materials","UNIVERSITAT AUTONOMA DE BARCELONA","ES","€2,499,940","With the advent of Big Data, information is facing new, potentially more damaging, security threats. The current trend to enhance data protection is to use increasingly complex mathematical algorithms to encrypt information. This approach requires exponentially growing amounts of data, time and power resources. REMINDS proposes a radically new concept to boost data security: to act directly at material level, i.e., in the way information is stored. The project is built on the disruptive idea of ",{"id":306,"funder":7,"programme":8,"title":307,"piName":10,"institution":308,"country":40,"year":13,"amount":309,"abstract":310},"cordis-european-research-council-award-101053576","Illuminating the enteroviral life cycle","UNIVERSITEIT UTRECHT","€2,396,392","Enteroviruses are highly prevalent pathogens that have enormous clinical and socio-economic impact. Well-known examples are poliovirus, coxsackievirus, enterovirus-A71, enterovirus-D68, and rhinovirus. Although important insights have been obtained in the enteroviral life cycle, many important questions remain unanswered due to shortcomings of current imaging and biochemical methodologies. There is a high need for novel technologies that allow sensitive and real-time observation of the dynamics ",{"id":312,"funder":7,"programme":8,"title":313,"piName":10,"institution":314,"country":315,"year":13,"amount":67,"abstract":316},"cordis-european-research-council-award-101054307","Life-history genes in fishes: bridging functional and evolutionary genetics for understanding life-history trait evolution","HELSINGIN YLIOPISTO","FI","Life history is one of the most central concepts in biology. Numerous biological questions ultimately revolve around the causes and consequences of variation in reproduction and survival i.e. fitness. Tremendous effort has been put in establishing the causes and mechanisms for life history trait variation and trade-offs. But even in well studied model organisms, evolutionary genetic and functional genomic approaches are rarely combined, and thus the path from genotype to phenotype often remains ",{"id":318,"funder":7,"programme":8,"title":319,"piName":10,"institution":320,"country":132,"year":13,"amount":67,"abstract":321},"cordis-european-research-council-award-101054984","Investigating mammalian evolution using million-year genomic transects","STOCKHOLMS UNIVERSITET","The field of ancient DNA has made major contributions to evolutionary biology and palaeontology in recent years, due to its power to reveal novel information about prehistory. However, even though many of the evolutionary processes that shaped the present-day biota have taken place over hundreds of thousands of years, nearly all ancient DNA studies to date have focused on biological changes during the last 50,000 years. I here propose a groundbreaking project that aims to study evolution on a mi",{"id":323,"funder":7,"programme":8,"title":324,"piName":10,"institution":325,"country":12,"year":13,"amount":326,"abstract":327},"cordis-european-research-council-award-101054961","Modelling Text as a Living Object in Cross-Document Context","TECHNISCHE UNIVERSITAT DARMSTADT","€2,499,721","Interpreting text in the context of other texts is very hard: it requires understanding the fine-grained semantic relationships between documents called intertextual relationships. This is critical in many areas of human activity, including research, business, journalism, and others. However, finding and interpreting intertextual relationships and tracing information throughout heterogeneous sources remains a tedious manual task. Natural language processing (NLP) fails to adequately support it: ",{"id":329,"funder":7,"programme":8,"title":330,"piName":10,"institution":331,"country":12,"year":13,"amount":120,"abstract":332},"cordis-european-research-council-award-101055339","Mechanoregulation of alternative splicing - a multi-omics and single cell approach to improved cardiac function","MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)","To adapt cardiac function in response to mechanical load, a network of splice factors concertedly regulates multiple target mRNAs that affect biomechanics, electrical activity, metabolism, signaling, and growth. It includes the splice regulator RBM20, with mutations causing severe cardiomyopathy, as well as its substrate titin, whose >350 exons are differentially joined to adjust the elastic properties of the sarcomere and thus ventricular filling. In the spliceosome, diverse RNAs and RNA bindin",{"id":334,"funder":7,"programme":8,"title":335,"piName":10,"institution":60,"country":33,"year":13,"amount":336,"abstract":337},"cordis-european-research-council-award-101053208","Exploring Cosmic Dawn with James Webb Space Telescope","€2,086,250","The cosmic dark ages - when the Universe was filled with neutral hydrogen that was opaque to ultraviolet light - are thought to have ended around one billion years after the Big Bang, when first light sources produced enough energetic photons to ionize the neutral hydrogen. This phase is referred to as the epoch of reionization and is also the era of the first galaxies' formation. However, this is also one of the least understood epochs in the Universe's evolution. When did it start\u002Fend?  Was it",{"id":339,"funder":7,"programme":8,"title":340,"piName":10,"institution":341,"country":40,"year":13,"amount":342,"abstract":343},"cordis-european-research-council-award-101054459","Modelling of three-phase flows with catalytic particles","TECHNISCHE UNIVERSITEIT EINDHOVEN","€2,499,481","This proposal is on modelling of 3 phase gas-solid-liquid multi-component flows with catalyst particles, which are frequently encountered in industrial applications, but have not been tackled fundamentally before due to their complexity.Dense multi-phase flows have been intensively researched because of their scientifically interesting transport phenomena and industrial applications. Considerable progress has been made for gas-solid and gas-liquid two-phase flows. However, catalytic multicompone",{"id":345,"funder":7,"programme":8,"title":346,"piName":10,"institution":78,"country":12,"year":13,"amount":347,"abstract":348},"cordis-european-research-council-award-101054950","Structural Basis for Centromere-Mediated Control of Error-free Chromosome Segregation","€2,209,886","Accurate chromosome segregation during cell division requires bipolar attachment of sister-chromatids to microtubules emanating from opposite spindle poles and maintenance of sister-chromatid cohesion until all chromosomes achieve bi-orientation.  Two chromosomal sites regulate these processes: centromeres, the microtubule attachment sites defined by the enrichment of CENP-A nucleosomes, and the inner centromere, a region between the sister-chromatids that recruits enzymatic activities (kinases,",{"id":350,"funder":7,"programme":8,"title":351,"piName":10,"institution":352,"country":12,"year":13,"amount":353,"abstract":354},"cordis-european-research-council-award-101054271","Future storage systems for the energy transition:  Polymer-based redox-flow batteries","FRIEDRICH-SCHILLER-UNIVERSITÄT JENA","€2,499,355","The efficient storage of electric energy represents a major challenge for a successful energy transition, enabling the utilization of fluctuating renewable resources also as base load. Redox-flow-batteries (RFBs) are the only type of battery where intrinsically power and capacity can be varied independently from each other, making this type of battery perfectly suited for scalable stationary applications. RFBs based on aqueous electrolytes with organic \u002F polymer active materials have the potenti",{"id":356,"funder":7,"programme":8,"title":357,"piName":10,"institution":358,"country":12,"year":13,"amount":67,"abstract":359},"cordis-european-research-council-award-101055340","Dendro-somatic Coupling and global neuronal signaling","HUMBOLDT-UNIVERSITAET ZU BERLIN","The mechanism for anaesthesia has eluded neuroscience despite being used as a medical intervention for more than two centuries. Two facts are clear: loss-of-consciousness under anaesthesia correlates with a massive reduction in global neuronal signalling and a de-coupling of feedback information. We recently found that the apical dendrites of layer 5 pyramidal neurons are effectively cut off from the cell body under anaesthesia and that higher order thalamic input maintains dendro-somatic coupli",{"id":361,"funder":7,"programme":8,"title":362,"piName":10,"institution":363,"country":12,"year":13,"amount":364,"abstract":365},"cordis-european-research-council-award-101054501","ENGINEERING CELLULAR SELF‐ORGANISATION BY  CONTROLLING THE IMMUNO-MECHANICAL INTERPLAY","CHARITE - UNIVERSITAETSMEDIZIN BERLIN","€2,490,725","Both scar formation and restitutio ad integrum during bone regeneration rely on cellular self-organisation that involve cell contraction and fibronectin\u002Fcollagen formation. This early stage of cellular self-organization is later followed by angiogenesis and mineralisation. Scar-free regeneration of physiological tissue homeostasis requires balanced downregulation of early inflammation, however little is understood of the immune-mechanical coupling involved. We aim to lay the foundation for reduc",{"id":367,"funder":7,"programme":8,"title":368,"piName":10,"institution":369,"country":12,"year":13,"amount":370,"abstract":371},"cordis-european-research-council-award-101096911","Breaking resistance of pathogenic bacteria by chemical dysregulation","TECHNISCHE UNIVERSITAET MUENCHEN","€2,499,785","Antibiotic resistant bacteria are on the rise and could trigger the next global pandemic. For some pathogens no treatment options are left, leading to steadily increasing death tolls. The limited scope of bacterial targets, all essential for growth, has favored resistance build-up whilst also being ineffective against non-growing persister cells. To overcome this threat, innovative concepts are required to effectively and sustainably kill bacteria via unprecedented mechanisms.My team and I tackl",{"id":373,"funder":7,"programme":8,"title":374,"piName":10,"institution":369,"country":12,"year":13,"amount":375,"abstract":376},"cordis-european-research-council-award-101098308","Soft-exoskeleton suit To Restore Autonomous Locomotion","€2,449,676","Imagine putting on a pair of pants, it feels soft like ordinary clothing fabrics, but unlike any other, this one is made of high-performance robotic soft actuators and soft sensors. This is my vision of future exoskeletons being just like everyday clothing, light, soft, and powerful enough to fully support the wearer.The loss of the ability to walk is devastating for many suffering from stroke, spinal cord injury, and alike. An ergonomic, light-weight exoskeleton can surely help these patients t",{"id":378,"funder":7,"programme":8,"title":379,"piName":10,"institution":380,"country":96,"year":13,"amount":381,"abstract":382},"cordis-european-research-council-award-101096203","Evolution in the Gut in Health and Disease","FUNDACAO GIMM - GULBENKIAN INSTITUTE FOR MOLECULAR MEDICINE","€2,499,821","The mammalian gut is an exquisite system to study ecology and evolution of microbes, and these processes are key for host-microbiome homeostasis. How microbiome diversity is maintained or lost is a critical question underlying the proper balance of this duet. Yet, our knowledge of the eco-evolutionary mechanisms structuring microbiomes is still in its infancy. Here, we seek to identify dominant modes of natural selection and host factors that modulate the evolution of their microbes. By leveragi",{"id":384,"funder":7,"programme":8,"title":385,"piName":10,"institution":386,"country":242,"year":13,"amount":387,"abstract":388},"cordis-european-research-council-award-101096090","Compositional Higher-Order Reasoning about Distributed Systems","AARHUS UNIVERSITET","€2,470,023","Software systems are critical for the infrastructure of modern society and software errors and security breaches pose enormous costs and risks. The traditional method of testing software systems is famously inadequate for guaranteeing the absence of errors and security breaches since not all execution paths are covered by testing. This is espcially true for concurrent and distributed systems, where there are simply too many execution paths to test, and it has motivated research in formal methods",{"id":390,"funder":7,"programme":8,"title":391,"piName":10,"institution":392,"country":85,"year":13,"amount":67,"abstract":393},"cordis-european-research-council-award-101053186","Non-invasive patterned electrical neurostimulation of the retina","TEL AVIV UNIVERSITY","Retinal implants remain one of the most demanding technologies in brain-machine interfacing. State of the art devices have yet to reach the needed performances. Main barriers are sub-optimal stimulation parameters and long development and testing procedures. While invasive approaches, have yet to achieve the resolution performances needed by million of patients blinded by retinal degenerative diseases, non-invasive approaches in the form of trans-orbital stimulation have received no attention, y",{"id":395,"funder":7,"programme":8,"title":396,"piName":10,"institution":397,"country":176,"year":13,"amount":398,"abstract":399},"cordis-european-research-council-award-101054524","New Catalysts for Synthesis of Stereodefined and Modifiable Tetrasubstituted Alkenes","CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION","€1,651,250","Tetrasubstituted olefins are key to drug discovery, and the ability to such entities is a compelling goal. Pioneering studies have led to a number of noteworthy advances by significant shortcomings remain. For example, it is especially challenging to access tetrasubstituted alkenes that contain four sizeable substituents or a F atom and\u002For a CF3 unit. Most protocols can only afford one of the possible isomers. Tetrasubstituted alkenes that contain multiple modifiable substituents are particularl",{"id":401,"funder":7,"programme":8,"title":402,"piName":10,"institution":403,"country":302,"year":13,"amount":404,"abstract":405},"cordis-european-research-council-award-101054354","Substellar Science with the Euclid Space Mission","INSTITUTO DE ASTROFISICA DE CANARIAS","€2,495,625","Euclid is a space mission led by the European Space Agency (ESA) to conduct a deep, single-epoch survey of 15,000 deg2 of sky with visible and near-infrared photometry and spectroscopy, and 40 deg2 multi-epoch very deep surveys. Its primary science goal is to investigate the geometry of the dark universe by mapping the distribution and shapes of galaxies.The unprecedented combination of sensitivity, areal coverage, spatial resolution, data homogeneity and spectral information will naturally be o",{"id":407,"funder":7,"programme":8,"title":408,"piName":10,"institution":11,"country":12,"year":13,"amount":409,"abstract":410},"cordis-european-research-council-award-101054637","Mitochondrial gene eXpression","€1,913,968","Mitochondrial gene expression is essential for cellular metabolism and energy supply since 13 core subunits of the OXPHOS system are encoded on the mitochondrial genome. Despite its importance for cellular function, mitochondrial gene expression (mitoGE) and its regulation are not understood at a mechanistic level. To this end, we demonstrated that mitochondrial translation is prone to regulation, responding to influx of nuclear-encoded proteins . However, the mechanisms that regulate gene expre",{"id":412,"funder":7,"programme":8,"title":413,"piName":10,"institution":107,"country":40,"year":13,"amount":67,"abstract":414},"cordis-european-research-council-award-101053581","Development of novel integrated sequencing methods to explore translation and its regulatory mechanisms in single cells","In recent years novel single-cell sequencing methods have allowed an in-depth analysis of the diversity of cell types and states in a wide range of organisms. Due to the continuous optimization of experimental and computational methods by many research groups, it is now possible to sequence the transcriptomes of thousands to millions of individual cells. Albeit an exciting development, transcription only covers the first step in the central dogma. The second step, the process of translation, is ",{"id":416,"funder":7,"programme":8,"title":417,"piName":10,"institution":418,"country":47,"year":13,"amount":67,"abstract":419},"cordis-european-research-council-award-101055323","Microglia As conTroller of braIn metaboLism During Aging","HUMANITAS MIRASOLE SPA","Microglia represent the main brain residential immune cells.  In the last years evidence emerged that, besides representing the first line of defense against pathogenic insults, microglia are also centrally involved in physiological functions essential for correct CNS development and function. Microglia, in a spatially and temporally controlled manner, influence neuronal apoptosis, neurogenesis and myelin formation and manage synapse homeostasis, including removing supernumerary synapses during ",{"id":421,"funder":7,"programme":8,"title":422,"piName":10,"institution":392,"country":85,"year":13,"amount":67,"abstract":423},"cordis-european-research-council-award-101055029","Circular RNA Therapeutics for Duchenne Muscular Dystrophy","RNA therapeutics is an emerging field explored in various types of diseases such as genetic disorders, cancer, inflammation and viral infections. Currently, most of the research focuses on the delivery of mRNA molecules that will transiently express a desired protein that can replace a defective protein or manipulate gene expression in the cells. My lab was the first to show systemic, cell-specific delivery of mRNA molecules in animals. Our approach and our novel amino lipids were translated to ",{"id":425,"funder":7,"programme":8,"title":426,"piName":10,"institution":427,"country":12,"year":13,"amount":67,"abstract":428},"cordis-european-research-council-award-101052876","Microbiome-derived asthma and allergy protective substances for prevention","HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH","Asthma and allergies are the epidemic of the 21st century after a sharp rise in prevalence since the middle of the last century. Asthma is the most common chronic condition for children – at school age about every 10th pupil is affected in westernized countries. Likewise, allergic illnesses are very prevalent with 30- 50 % of the paediatric population being affected. Currently, there is neither cure nor effective prevention. However, asthma and allergies are illnesses, which are largely environm",{"id":430,"funder":7,"programme":8,"title":431,"piName":10,"institution":369,"country":12,"year":13,"amount":432,"abstract":433},"cordis-european-research-council-award-101094463","Generative Understanding of Ultrafast Fluid Dynamics","€2,481,873","Fluids are fundamental to a wide spectrum of natural phenomena and technological applications. Spectacular manifestations of patterns and order arise at small spatiotemporal scales from ultra-fast fluid dynamics (UFD). Initiated by focused deposition of high thermal energy, causing local disruption of equilibrium, violent competing fluid dynamics with extreme local state variations characterize the subsequent relaxation. UFD offer a unique potential for exploration in micro-manufacturing and ene",{"id":435,"funder":7,"programme":8,"title":436,"piName":10,"institution":437,"country":302,"year":13,"amount":438,"abstract":439},"cordis-european-research-council-award-101097688","Perovskite Spiking Neurons for Intelligent Networks","UNIVERSITAT POLITECNICA DE VALENCIA","€2,498,004","A brain is a complex structure where computing and memory are tightly intertwined at very low power cost of operation, by analog signals across vast quantities of synapse-connected spiking neurons. Animal brains react intelligently to environmental events and perceptions. By developing similar Spiking Neural Networks (SNN) we can realize neuromorphic computation systems excellent for dealing with large amounts of noisy data and stimuli and very well suited for perception, cognition and motor tas",{"id":441,"funder":7,"programme":8,"title":442,"piName":10,"institution":443,"country":302,"year":13,"amount":444,"abstract":445},"cordis-european-research-council-award-101054313","Patterns of Spontaneous Activity in the Assembly and Rewiring of Functional Sensory Circuits","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","€2,494,220","It is commonly held that spontaneous activity in the immature brain prepares the neural circuits to process sensory information at the onset of experience. The best studied patterns of such activity are those observed postnatally in rodents, during stages that resemble the last months of gestation in humans. However, the features and functions of spontaneous activity at earlier stages, when the brain’s foundations are laid down and cortical areal identities are acquired, remain largely unknown. ",{"id":447,"funder":7,"programme":8,"title":448,"piName":10,"institution":449,"country":176,"year":13,"amount":450,"abstract":451},"cordis-european-research-council-award-101097351","In-silico Models for the Design of  Mechanochromic Functionalized Polymers","ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS","€2,493,750","The MaMa project aims at developing integrated computational approaches enabling to describe and design new mechanochromic materials. In particular, we aim at rationally design technologically consistent commodity polymers with smart and intelligent features such as mechano-responsive elastomeric, thermoplastic and thermoset polymers by the introduction of chromogenic species in the polymeric matrix in the form of mechanophore chromophores. The inter- or intra-molecular interactions ruling the o",{"id":453,"funder":7,"programme":8,"title":454,"piName":10,"institution":443,"country":302,"year":13,"amount":10,"abstract":455},"cordis-european-research-council-award-101098309","Exploring the pristine conditions for transforming interstellar dust into planetesimals","The formation and properties of exoplanetary systems is a fascinating question, which has been at the heart of our quest to define mankind and the conditions for life to develop in a broader context.Recent astronomical observations have deeply modified our paradigm of planet formation, as they suggest the so-called proto-planetary” disks surrounding T-Tauri stars may actually already host planets. Moreover, we have obtained some of the first observational clues that the dust particles contained ",{"id":457,"funder":7,"programme":8,"title":458,"piName":10,"institution":459,"country":176,"year":13,"amount":10,"abstract":460},"cordis-european-research-council-award-101096610","Anyon Statistics in Tiny Electronic Colliders","SORBONNE UNIVERSITE","In three dimensional systems, elementary particles are divided exclusively between fermions (which exclude each others) and bosons (which bunch together) according to the phase acquired by the wavefunction when two particles are exchanged. The situation is different in two-dimensional systems which can host new particles called anyons, for which the exchange phase can take any value, and which obey partial exclusion, between fermions and bosons. Interestingly, these quasiparticles keep a memory ",{"id":462,"funder":7,"programme":8,"title":463,"piName":10,"institution":459,"country":176,"year":13,"amount":464,"abstract":465},"cordis-european-research-council-award-101097755","Quantum Optical Physics with Neutral-Atom Waveguide-QED","€2,498,750","The coupling of cold atoms to nanophotonic devices has recently opened a variety of novel opportunities for controlling light-matter interactions. Tailored dispersion relations offer unique features beyond conventional settings. In particular, photonic-crystal waveguides enable tight transverse confinement of the propagating light, strong atom-photon coupling in single pass and tunable long-range atom-atom interactions. While this research area is extensively studied theoretically, experimental ",{"id":467,"funder":7,"programme":8,"title":468,"piName":10,"institution":469,"country":176,"year":13,"amount":470,"abstract":471},"cordis-european-research-council-award-101098236","HOst-Transposon Interactions in the MAle GErmline","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","€2,499,276","Transposable elements (TEs) are mobile DNA sequences that have massively colonized mammalian genomes. Host genomes and TEs are engaged in ambiguous trade-offs, whereby TEs can be co-opted for genomic upgrades over evolutionary timescales, but they should also be suppressed to protect genome stability and function. Effective and multi-layered surveillance is primordial: TE reactivation is associated with various dysfunctional states, including infertility, ageing, cancer or neurological disorders",{"id":473,"funder":7,"programme":8,"title":474,"piName":10,"institution":475,"country":176,"year":13,"amount":67,"abstract":476},"cordis-european-research-council-award-101097330","Intestinal Gluconeogenesis: Emerging Regulator of Energy Homeostasis","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","Obesity and type 2 diabetes continuously progress worldwide, compromising healthy aging. Deregulated endogenous glucose production (EGP) is involved in hyperglycemia and its complications. Among the 3 organs (liver, kidney, intestine) contributing to EGP, I uncovered with my team that intestinal gluconeogenesis (IGN) has the capacity to interfere in the control of energy homeostasis. Indeed, intestinal glucose initiates a gut-brain circuit controlling both body weight and glucose production by t",{"id":478,"funder":7,"programme":8,"title":479,"piName":10,"institution":443,"country":302,"year":13,"amount":480,"abstract":481},"cordis-european-research-council-award-101054883","Medieval Appetites: food plants in multicultural Iberia (500-1100 CE)","€2,498,845","The Islamic conquest of Iberia in the 8th century brought in profound changes in the political, social and economic realms that transformed the everyday life of local rural and urban communities. Technological innovations and the arrival of new crops impacted their agriculture, diet and culinary practices.Plants were present in almost all aspects of medieval people’s ordinary lives (food, crafts, medicines, etc.). However, they have been commonly sidelined in discussions of the past. Most of wha",{"id":483,"funder":7,"programme":8,"title":484,"piName":10,"institution":443,"country":302,"year":13,"amount":485,"abstract":486},"cordis-european-research-council-award-101096293","The trail of sulphur: from molecular clouds to life","€2,191,875","Sulphur is the tenth most abundant element in the Universe and is known to play a significant role in biological systems. Moreover, some sulphur compounds have been proposed as necessary catalysts to form amino acids in the interstellar medium. However, while the carbon and oxygen budgets have been extensively studied, sulphur is the only element whose gas-phase abundance is still uncertain by several orders of magnitude, hindering the usage of elemental sulphur abundance as a reliable tool to p",{"id":488,"funder":7,"programme":8,"title":489,"piName":10,"institution":490,"country":12,"year":13,"amount":491,"abstract":492},"cordis-european-research-council-award-101097876","Origami inspired thermoelectric generators by printing and folding","KARLSRUHER INSTITUT FUER TECHNOLOGIE","€2,410,155","The transition towards an energy-sustainable society is the key challenge for the engineering sciences in the 21st century. This proposal addresses the energy supply for the future trillion sensor devices that form the backbone of our digitized society and it addresses the possibility to recover huge amounts of low-temperature waste heat in industry. Energy-harvesting from low-temperature environmental heat via thermoelectric generators (TEG) is a versatile and maintenance-free solution for both",{"id":494,"funder":7,"programme":8,"title":495,"piName":10,"institution":496,"country":12,"year":13,"amount":10,"abstract":497},"cordis-european-research-council-award-101096190","The ‘orphan’ boundary type in plate tectonics:  oceanic transform faults reconstructed","HELMHOLTZ-ZENTRUM FUR OZEANFORSCHUNG KIEL (GEOMAR)","The plate tectonic revolution gave birth to three types of plate boundaries; two got most of the interest, i.e., the mid-ocean ridges where new ocean floor is formed and subduction zones where the lithosphere is recycled back into the Earth’s interior. In the oceans, the third type, the “simple” strike-slip conservative plate boundary or oceanic transform fault (OTF), was treated like an orphan in a Charles Dickens novel. However, recent observations challenge plate tectonics, revealing that OTF",{"id":499,"funder":7,"programme":8,"title":500,"piName":10,"institution":475,"country":176,"year":13,"amount":501,"abstract":502},"cordis-european-research-council-award-101098103","Time-based single molecule nanolocalization for live cell imaging","€2,498,196","Despite the tremendous advances in single molecule localization microscopy mainly obtained on fixed cells, a major step is highly needed to transform it into a genuine live-cell nanoscopy allowing to understand biological processes in their full multi-scale nature from the individual molecule, to the cell, to the multicellular tissues. Currently, there is no solution to image with an acquisition speed compatible with the dynamics of living cells (>kHz), over a large volumes (>10000 m3), with a s",{"id":504,"funder":7,"programme":8,"title":505,"piName":10,"institution":506,"country":47,"year":13,"amount":507,"abstract":508},"cordis-european-research-council-award-101097155","EXPanding AAV gene therapy by EDITing","FONDAZIONE TELETHON ETS","€2,492,303","In vivo gene therapy based on a single administration of adeno-associated viral (AAV) vectors is emerging as an effective therapeutic option for both monogenic and complex diseases. Given the episomal nature of the AAV genome, its applications are limited to non-replicating tissues like retina or adult liver. Several AAV-based products that target these tissues are either approved or in advanced clinical development. Despite this, some limitations still remain, including: the potential for inser",{"id":510,"funder":7,"programme":8,"title":511,"piName":10,"institution":512,"country":12,"year":13,"amount":513,"abstract":514},"cordis-european-research-council-award-101097056","Trust-by-Design – Strong Security Arguments for Symmetric Key Cryptography","RUHR-UNIVERSITAET BOCHUM","€2,485,000","Symmetric cryptographic primitives protect a large percentage of today's data, whether in transit or storage. This trend is going to increase even more in the future. Consequently, new domain-specific ciphers are needed with significant performance benefits for areas such as memory-encryption, multi-party computation, or crypto-currencies. Great progress has been made regarding their performance. Less progress has been made for security arguments that seek to proof their resilience against malig",{"id":516,"funder":7,"programme":8,"title":517,"piName":10,"institution":60,"country":33,"year":13,"amount":10,"abstract":518},"cordis-european-research-council-award-101095729","The roles of the agency of the dead in the lives of individuals in contemporary society","Each from their own perspectives, various disciplines have shed light on the roles fulfilled by the dead in contemporary society. Their findings, however, remain compartmentalised, their insights scattered; a comprehensive understanding of their role in the lives of individuals is still missing. This project will benefit from the insights of each of them, with the aim to transform the current partial understandings into a complex view of the roles that the dead play in individuals’ lives. Instea",{"id":520,"funder":7,"programme":8,"title":521,"piName":10,"institution":341,"country":40,"year":13,"amount":522,"abstract":523},"cordis-european-research-council-award-101098234","Stabilization of Protein Protein Interactions; transforming molecular glue discovery from art into science","€2,496,596","Intrinsically Disordered Proteins (IDPs) represent one of drug discovery’s major challenges. Due to their high degree of conformational freedom, IDPs have no defined pockets for binding small molecules. Molecular glues that can strengthen protein-protein interactions (PPIs) are a revolutionary technology for drug discovery. The hub protein 14-3-3 regulates many IDPs via phosphorylation-dependent PPIs. Stabilization of 14-3-3 PPIs with small molecular glues provides a unique entry point to render",{"id":525,"funder":7,"programme":8,"title":526,"piName":10,"institution":182,"country":85,"year":13,"amount":527,"abstract":528},"cordis-european-research-council-award-101097966","Continuous electrolytic-catalytic decoupled water electrolysis for green hydrogen production","€2,950,000","H2Bro will develop a transformative decoupled water electrolysis process for green hydrogen production. It aims for high efficiency in a continuous and isothermal process that supports membraneless electrolysis with high-throughput and minimal energy losses, going far beyond other electrolysis processes. I propose to achieve these goals by dividing the oxygen evolution reaction into two sub-reactions, electrochemical and chemical ones, carried out in different cells. Towards this end, I propose ",{"id":530,"funder":7,"programme":8,"title":531,"piName":10,"institution":532,"country":176,"year":13,"amount":533,"abstract":534},"cordis-european-research-council-award-101098032","Mapping Internet Routes for Geopolitics","UNIVERSITE PARIS 8 VINCENNES SAINT-DENIS","€2,499,587","The Internet has been able to grow and develop very quickly in most countries because of its highly decentralized nature. Its resilience is based on a multiplicity of different paths that allow data to always bypass a blockage or a partial destruction of the network through alternative routes. This model is today called into question by a combination of dynamics. First, we observe a dynamic of fragmentation along national borders, at the initiative of some states who, in the name of national sec",{"id":536,"funder":7,"programme":8,"title":537,"piName":10,"institution":475,"country":176,"year":13,"amount":538,"abstract":539},"cordis-european-research-council-award-101098375","Convection and transfers in a textured partially-molten planet from the magma ocean stage to present-day solid-state convection","€3,418,549","How and when plate tectonics (PT) developed on Earth, and why the Earth is currently the only rocky planet of the solar system with PT, are two of the main enigmas of Earth and Planetary Sciences. The evolution of a planet is conditioned by heat transfer in its most viscous envelope, the mantle. This heat transfer is mostly due to convection, and strongly depends on the convective patterns, which in turn depends critically on mantle rheology. However, the link between rock rheology at small time",{"id":541,"funder":7,"programme":8,"title":542,"piName":10,"institution":543,"country":12,"year":13,"amount":544,"abstract":545},"cordis-european-research-council-award-101097402","Causal Roles of Intrinsic Coupling Modes: an Integrated Multiscale Framework for Cognitive Network Dynamics","UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF","€2,499,250","Functional coupling is a hallmark of brain networks, and there is a wealth of studies that have observed a relation between functional connectivity and cognition or sensorimotor processing. However, the vast majority of studies on this topic are correlative in nature, and causal evidence for the role of functional coupling is almost completely lacking. This project aims to fill this gap. Most of the coupling is intrinsically generated and occurs at multiple spatial and temporal scales. We will f",{"id":547,"funder":7,"programme":8,"title":548,"piName":10,"institution":549,"country":47,"year":13,"amount":550,"abstract":551},"cordis-european-research-council-award-101096728","At the ‘roots’ of motor intentions","UNIVERSITA DEGLI STUDI DI PADOVA","€3,148,411","Research in cognitive science has revealed that intentions become “visible” in the surface flow of agents’ motion. An example is that humans adopt different kinematics when reaching for an object to either displace it (i.e., individual intentions) or interact with a partner (i.e., social intentions). This phenomenon has been shown in humans and other animal species, but no studies have investigated whether it extends to the “green” kingdom. ROOMors aims at investigating for the first time motor ",{"id":553,"funder":7,"programme":8,"title":554,"piName":10,"institution":555,"country":235,"year":13,"amount":556,"abstract":557},"cordis-european-research-council-award-101096629","STONE-WORK: collective achievement in Anglo-Irish architectural production, 1700-1800","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","€2,499,708","STONE-WORK challenges the perception of architecture as a primarily conceptual activity by shifting focus from individual to collective achievement. Despite the emphatic materiality of architecture its history remains dominated by a sequential model which privileges the agency of individuals and ideas. STONE-WORKs fundamental premise is that architecture results from a cumulative sequence of actions involving an array of actors, great and small. There can be no buildings without materials and no",{"id":559,"funder":7,"programme":8,"title":560,"piName":10,"institution":358,"country":12,"year":13,"amount":561,"abstract":562},"cordis-european-research-council-award-101097219","High-Precision Gravitational Wave Physics from a Worldline Quantum Field Theory","€2,195,121","This project will determine the gravitational waves emitted in the encounter of two black holes or neutron stars in our universe at highest-precision. The gravitational waves emerging from such violent mergers are now routinely detected at the LIGO-Virgo-KAGRA observatories since their discovery in 2016. With the presently planed third generation of observatories the experimental accuracy will dramatically increase. Theoretical predictions for the emitted waveforms at highest-precision are there",{"id":564,"funder":7,"programme":8,"title":565,"piName":10,"institution":566,"country":176,"year":13,"amount":67,"abstract":567},"cordis-european-research-council-award-101095764","From fiber to wall: PHYSical approach of hygrothermal transfers in BIO-based construction MATerials","UNIVERSITE GUSTAVE EIFFEL","Bio-based construction materials are air-fiber systems, such as wood, hemp, cellulose, flax, etc., possibly coated with a mineral paste. They represent a promising solution for carbon emission reduction, due to their low production cost and their partial or full recyclability. Moreover, they bring more comfort to the occupants thanks to their moisture-buffering capacity, and they require less energy for heating or cooling. These qualities are obtained through exchanges between water vapor and bo",{"id":569,"funder":7,"programme":8,"title":570,"piName":10,"institution":571,"country":20,"year":13,"amount":572,"abstract":573},"cordis-european-research-council-award-101096163","Targeting skin glycosylation patterns to protect threatened salamanders from disease driven extinction","UNIVERSITEIT GENT","€2,479,125","Disease driven amphibian declines are frequently compared to the extinction of dinosaurs and have become an icon of the global biodiversity crisis. The deadly skin disease chytridiomycosis is causing the greatest recorded loss of biodiversity attributable to a disease. The recently introduced chytrid fungus Batrachochytrium salamandrivorans (Bsal) is expanding its range in Europe, remains unmitigated and thus poses an imminent threat to western Palearctic urodele (= salamanders and newts) divers",{"id":575,"funder":7,"programme":8,"title":576,"piName":10,"institution":577,"country":132,"year":13,"amount":578,"abstract":579},"cordis-european-research-council-award-101096705","Imidazole propionate and fibrosis in cardiometabolic diseases","GOETEBORGS UNIVERSITET","€2,482,678","Fibrosis is a pathological feature caused by excessive extracellular matrix secretion, resulting in scar tissue that causes thickening and loss of tissue mobility, culminating in impaired organ function. It is a common feature of heart failure and non-alcoholic steatohepatitis and an important determinant of morbidity and mortality. However, relatively little is known about the underlying aetiology.  We and others have mapped alterations in the gut microbiota in different cardiometabolic disease",{"id":581,"funder":7,"programme":8,"title":582,"piName":10,"institution":583,"country":12,"year":13,"amount":584,"abstract":585},"cordis-european-research-council-award-101098225","Seeing Stuff: Perceiving Materials and their Properties","JUSTUS-LIEBIG-UNIVERSITAET GIESSEN","€2,499,711","Different materials, such as silk, soil, steel and soap exhibit an astonishing variety of physical properties, appearances and behaviours. The material properties of objects and substances are central to practically every task we perform, from selecting and preparing food, to detecting slippery ground, to using tools effectively. Without touching a surface, we usually enjoy a vivid impression of what it would feel like, through the sense of sight. Yet, how we do so remains mysterious. Decades of",{"id":587,"funder":7,"programme":8,"title":588,"piName":10,"institution":589,"country":20,"year":13,"amount":590,"abstract":591},"cordis-european-research-council-award-101094311","Biodiversity, Local Knowledge and Zoonoses in Austronesia: Ethnography of Bats and Related Interspecific Communities","UNIVERSITE CATHOLIQUE DE LOUVAIN","€2,495,644","The proposed research lies at the juncture of the anthropology of nature, the cultures of Austronesia and the study of interspecific relationships. Considering that a fundamental link exists between biodiversity and the health of individuals, populations, species and ecosystems, and that microbes, bacteria and viruses are key to the evolution of civilisations and living beings, we will address two questions: 1) In a world going through a livestock revolution, to what extent can local and scienti",{"id":593,"funder":7,"programme":8,"title":594,"piName":10,"institution":595,"country":164,"year":13,"amount":596,"abstract":597},"cordis-european-research-council-award-101097789","The Macroeconomics of Managers","CEU GMBH","€1,782,794","There are enormous differences in productivity both across countries and across firms within the same country. Not only is the average firm less productive in poor countries, the allocation of resources across firms is also less efficient. Good management is understood as one of the key determinants of firm performance. Why don't management best practices spread from good firms to bad ones and from rich countries to poor ones? In order to explain management practices and productivity at the macr",{"id":599,"funder":7,"programme":8,"title":600,"piName":10,"institution":269,"country":12,"year":13,"amount":10,"abstract":601},"cordis-european-research-council-award-101097850","Lepton Symmetry Experiment – matter \u002F antimatter symmetry test with electron and positron","In modern physics we are faced with the unsatisfactory situation that the Standard Model (SM), which condenses our current state of knowledge in the form of quantum field theories, despite its spectacular success in the prediction of laboratory results, fails in explaining even the most basic properties of our Universe, such as the disparity of matter and antimatter and the possible existence of dark matter. In the quest to search for answers to these questions, low energy, high precision experi",{"id":603,"funder":7,"programme":8,"title":604,"piName":10,"institution":358,"country":12,"year":13,"amount":605,"abstract":606},"cordis-european-research-council-award-101096682","Data Privacy in Digital Markets","€1,860,125","Focusing on verifiability, PRIVDIMA studies the regulation of data privacy to protect consumers from excessive price discrimination in digital markets.PRIVDIMA breaks with previous literature by acknowledging that data has a verifiability effect. It proposes a study of data privacy regulation by explicitly modelling this verifiability effect. Its motivation is as follows: 1) data collection in digital markets renders private information verifiable; 2) due to unravelling, this verifiability effec",{"id":608,"funder":7,"programme":8,"title":609,"piName":10,"institution":610,"country":47,"year":13,"amount":611,"abstract":612},"cordis-european-research-council-award-101094471","When enzymes join forces: unmasking a mitochondrial biosynthetic engine","UNIVERSITA DEGLI STUDI DI PAVIA","€2,107,750","Enzymes have been classically investigated as standalone catalysts operating in a relatively diluted milieu. However, the cell micro-compartments are highly crowded environments and biological catalysis cannot be fully understood on the bases of simple diffusive models. We are tackling this challenge by reconstituting a full-scale biosynthetic pathway where multiple enzymes coordinate within a metabolon - a structurally defined setting that allows the vectorial transfer of substrates and product",{"id":614,"funder":7,"programme":8,"title":615,"piName":10,"institution":616,"country":12,"year":13,"amount":544,"abstract":617},"cordis-european-research-council-award-101098156","Energy Transfer Catalysis: A Highway to Molecular Complexity","UNIVERSITAET MUENSTER","The development of novel synthetic methodologies is one of the most essential chemical research areas since the access to organic molecules is the foundation for many applied sciences (e.g. medicinal chemistry, materials science). In recent years, the construction of increasingly complex molecular scaffolds has gained significance, with a particular need for conformationally restricted, three-dimensional architectures. However, the synthesis of such molecular frameworks remains exceptionally cha",{"id":619,"funder":7,"programme":8,"title":620,"piName":10,"institution":621,"country":176,"year":13,"amount":622,"abstract":623},"cordis-european-research-council-award-101097172","Geometry, Control and Genericity for Partial Differential Equations","UNIVERSITE PARIS-SACLAY","€1,647,938","Many physics models are described by waves or more generally dispersive equations (Schrdinger equations) with propagation in a non homogeneous and bounded medium. Toy models (mostly in flat backgrounds) have been developed by mathematicians. However, many questions remain open even on these simplified models in the presence of inhomogeneities and boundaries.  In particular, the works of mathematicians in the last decade have allowed to exhibit some pathological behaviours which appear to be quit",{"id":625,"funder":7,"programme":8,"title":626,"piName":10,"institution":392,"country":85,"year":13,"amount":627,"abstract":628},"cordis-european-research-council-award-101097959","New Frontiers in Information-Theoretic Secure Computation","€2,113,125","Information-theoretic secure computation is a general-purpose technique for processing sensitive data without compromising its confidentiality or integrity even in the presence of a computationally-unbounded all-powerful adversary. This notion plays an important role in cryptography, both as a stand-alone object and as a tool for computational constructs. Despite its increasing importance, we have a very limited understanding of the *intrinsic complexity* of information-theoretic security, and s",{"id":630,"funder":7,"programme":8,"title":631,"piName":10,"institution":475,"country":176,"year":13,"amount":632,"abstract":633},"cordis-european-research-council-award-101097856","Nanostructure-Based Design of Visual Perception using High-Index Disordered Metasurface Physics","€2,108,656","The optics of disordered media with subwavelength high-contrast resonant inhomogeneities is a fascinating research topic emerging at the interface between the physics of waves in complex media and nanophotonics. UNSEEN explores and exploits unconventional wave-interference phenomena in disordered metasurfaces towards a new application: the creation of brand-new visual appearance.Our perception of objects is completely determined by how they scatter light. Color is crucial, but other attributes, ",{"id":635,"funder":7,"programme":8,"title":636,"piName":10,"institution":637,"country":176,"year":13,"amount":638,"abstract":639},"cordis-european-research-council-award-101097364","Reconstructing the Pagan Religion of Tibet","ECOLE PRATIQUE DES HAUTES ETUDES","€2,492,375","Buddhism was introduced to Tibet in the 7th century CE and became the official national religion in the 8th. A small percentage of Tibetans are followers of a religion called Bn, which its adherents (Bnpos) and Buddhists alike consider to be the countrys indigenous faith. Bn came to acquire many Buddhist features but retained a strand of more archaic traditions. Since there is no evidence that these traditions were actually called Bn prior to the establishment of Buddhism, we refer to them colle",{"id":641,"funder":7,"programme":8,"title":642,"piName":10,"institution":643,"country":176,"year":13,"amount":644,"abstract":645},"cordis-european-research-council-award-101095866","Brain mechanisms underlying mathematics and its acquisition","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","€2,857,101","Mathematics is a fundamental tool by which we understand the universe, yet its cognitive and brain mechanisms are vastly understudied. I propose a systematic study of the human representation of mathematical concepts and their growth with education. The project will test the “language of thought” theory according to which humans share core concepts with other animals (numbers, objects, shapes, spatial maps) but the growth of math relies on a human symbolic composition system that recursively rec",{"id":647,"funder":7,"programme":8,"title":648,"piName":10,"institution":649,"country":47,"year":13,"amount":650,"abstract":651},"cordis-european-research-council-award-101095900","Triangulated categories and their applications, chiefly to algebraic geometry","UNIVERSITA DEGLI STUDI DI MILANO","€1,042,645","There are two components to this project.  (1) Develop and extend the striking new theory, created by the PI in the  last few years, which studies triangulated categories via metrics  and approximations.  (2) Build on very recent work to better understand which functors are Fourier-Mukai and which aren't.  In the case of (1), the novel idea of appropriately using metrics has already allowed the PI to prove several difficult conjectures, the most recent just a few weeks ago. The potential of the ",{"id":653,"funder":7,"programme":8,"title":654,"piName":10,"institution":655,"country":119,"year":13,"amount":656,"abstract":657},"cordis-european-research-council-award-101097317","Principles of endogenous and therapeutic mRNA turnover in vivo","MIEDZYNARODOWY INSTYTUT BIOLOGII MOLEKULARNEJ I KOMORKOWEJ W WARSZAWIE","€2,499,875","During the COVID-19 pandemic, we witnessed the application of mRNA vaccines for SARS-CoV-2, paving the way for the widespread use During the COVID-19 pandemic, we witnessed the application of mRNA vaccines for SARS-CoV-2, paving the way for the widespread use of therapeutic mRNAs in medicine. However, lack of knowledge regarding mRNA metabolism in vivo limits the optimization and refinement of such therapies. Our preliminary data, acquired via Direct RNA Sequencing (DRS), shows that variability ",{"id":659,"funder":7,"programme":8,"title":660,"piName":10,"institution":661,"country":12,"year":13,"amount":662,"abstract":663},"cordis-european-research-council-award-101097307","Automata, Dynamics and Actions","UNIVERSITAT DES SAARLANDES","€2,419,896","This project lies at the nexus of complex and symbolic dynamics, group theory, decision problems and computation. It aims to solve major problems in each of these fields by means of automatic actions and relations.Finite state automata, pervasive in theoretical computer science, will serve to define self-similar mathematical objects, and produce efficient algorithms to manipulate them. — I will explore a novel notion of automatically acting group, encompassing the previously unrelated notions of",{"id":665,"funder":7,"programme":8,"title":666,"piName":10,"institution":380,"country":96,"year":13,"amount":10,"abstract":667},"cordis-european-research-council-award-101097801","Plasmodium liver stage schizogony: high replication and genetic diversity","A world free of malaria is certainly a desirable goal. However, in spite of the significant incidence reduction achieved globally between 2000-2015, malaria still kills a child every minute. The limited understanding of Plasmodium’s biology hampers the development of novel intervention strategies. Upon transmission by Anopheles mosquitos, Plasmodium parasites must reach the liver and infect hepatocytes. Inside a hepatocyte, each parasite replicates into thousands of new erythrocyte-infectious fo",{"id":669,"funder":7,"programme":8,"title":670,"piName":10,"institution":269,"country":12,"year":13,"amount":464,"abstract":671},"cordis-european-research-council-award-101097844","New Windows onto the Sun: Probing the Sun’s magnetic field with an array of new missions and observatories","The Sun provides the energy necessary to sustain life on Earth, making it a star of unique importance for human society. It is also the only star whose surface we can resolve to reveal the richness of the complex processes acting there, creating a highly dynamic and varied environment. Much of the structure and dynamics visible on the Sun is caused by the intricately structured magnetic field and its interaction with the turbulent plasma. However, there are considerable gaps in our knowledge of ",{"id":673,"funder":7,"programme":8,"title":674,"piName":10,"institution":675,"country":12,"year":13,"amount":676,"abstract":677},"cordis-european-research-council-award-101098216","Layering, Understanding, Controlling and Integrating  Ferroelectric Polar Textures on Silicon","HELMHOLTZ-ZENTRUM BERLIN FUR MATERIALIEN UND ENERGIE GMBH","€2,499,960","Ferroelectric materials have been known, and their fascinating properties exploited for more than 100 years. Still, in recent years, exotic polar textures resembling those found in magnetic materials have been unraveled in nanoscale ferroelectric perovskite oxides, such as flux closure domains, curling polarization, vortices, and the groundbreaking discoveries of polar skyrmions and merons in 2019\u002F2020. Polar textures hold huge promise for novel robust topological electronic devices such as ultr",{"id":679,"funder":7,"programme":8,"title":680,"piName":10,"institution":72,"country":47,"year":13,"amount":10,"abstract":681},"cordis-european-research-council-award-101097687","Monopsony Power and Inequality","What is the role played by monopsony (monopoly power in the demand for labor) in widening earning inequalities? Recent studies documented the pervasiveness of monopsony power in modern labor markets. Monopsonistic employers can cut wages without losing workers to competitors, pay labor below its productivity and hire fewer workers than in a competitive labor market. The equilibrium is inefficient as the surplus given by market power is lower than the surplus extracted from workers who are also e",{"id":683,"funder":7,"programme":8,"title":684,"piName":10,"institution":685,"country":12,"year":13,"amount":686,"abstract":687},"cordis-european-research-council-award-101097411","The neural basis of dynamic territorial aggression and fear","EUROPEAN MOLECULAR BIOLOGY LABORATORY","€2,496,895","The urge to defend one’s territory is an evolutionarily conserved instinct aimed at securing optimal access to food, mates, and shelter. Conflict arises when territories become unstable due to seasonal changes in resource availability, or when population density increases. Under such conditions, individuals must carefully balance social aggression and avoidance to maximize their control of territorial resources while avoiding subordination at the hands of their neighbors. What is the neural basi",{"id":689,"funder":7,"programme":8,"title":690,"piName":10,"institution":392,"country":85,"year":13,"amount":67,"abstract":691},"cordis-european-research-council-award-101098318","Plant bioacoustics: on the emission and reception of airborne sounds by plants, and their adaptive value.","The communication of plants with their environment is crucial for their survival. Plants are known to uselight, odours, and touch to communicate with other plants, with pollinators, seed dispersers and herbivores.However, one sensory modality  acoustic communication  is almost unexplored in plants, despite itspotential adaptive value. This is the focus of the current proposal.Our long-term goal is to understand the roles of acoustic communication in the life of plants: what plantshear, and what ",{"id":693,"funder":7,"programme":8,"title":694,"piName":10,"institution":695,"country":302,"year":13,"amount":696,"abstract":697},"cordis-european-research-council-award-101096215","Advances in Empirical Methods for Time Series and Forecasting in Unstable Environments","UNIVERSIDAD POMPEU FABRA","€859,950","The environment we live in is both complex and time varying. Examples of recent instabilities include the recent financial crises as well as the more recent COVID-19 pandemic and the war in Ukraine, which have substantially altered our world. Currently, however, the way researchers implement forecasts as well as the way they estimate the effects of economic policies is based on methods that either impose restrictive assumptions on the nature of instabilities or quickly become computationally dem",{"id":699,"funder":7,"programme":8,"title":700,"piName":10,"institution":437,"country":302,"year":13,"amount":701,"abstract":702},"cordis-european-research-council-award-101097092","Analog Photonic Computation","€2,491,250","For over 5 decades, digital electronics has covered the increasing demand for computing power thanks to a periodic doubling of transistor density in integrated circuits. Currently, such scaling law is reaching its fundamental limit, leading to the emergence of a large gamut of applications that cannot be supported by digital electronics, specifically, those that involve real-time analog multi-data processing, e.g., medical diagnostic imaging, drug design and robotic control, among others. Here, ",{"id":704,"funder":7,"programme":8,"title":705,"piName":10,"institution":706,"country":176,"year":13,"amount":707,"abstract":708},"cordis-european-research-council-award-101096956","DNA-encoded REconfigurable and Active Matter","ECOLE NORMALE SUPERIEURE","€2,496,750","Synthetic materials exist in a broad variety of sizes, shapes and compositions leading to an impressive breadth of useful functions but tend to be case-specific. Living matter, in contrast, has the remarkable capability to sense, evolve, transform and adapt. Here, we propose to develop new DNA-encoded dynamic principles and implement them as molecular codes to program similar life-like characteristics in a variety of synthetic soft materials, ranging from evolutive DNA nanomachines to geneticall",{"id":710,"funder":7,"programme":8,"title":711,"piName":10,"institution":712,"country":713,"year":13,"amount":10,"abstract":714},"cordis-european-research-council-award-101095925","Altermagnetism and spintronics without magnetization and relativity","FYZIKALNI USTAV AV CR, VVI","CZ","Magnetically ordered crystals are traditionally divided into two basic phases -- ferromagnetism and antiferromagnetism. The ferromagnetic order offers a range of phenomena and device applications. The vanishing net magnetization in antiferromagnets is potentially favorable for spatial and temporal scalability of devices. Recently, our team and others have predicted instances of strong time-reversal symmetry breaking and spin splitting in electronic bands, typical of ferromagnetism, in crystals w",{"id":716,"funder":7,"programme":8,"title":717,"piName":10,"institution":718,"country":12,"year":13,"amount":719,"abstract":720},"cordis-european-research-council-award-101098003","Spatio-temporal integration of skin inflammation","DEUTSCHES RHEUMA FORSCHUNGSZENTRUMBERLIN","€2,499,188","To ‘feel comfortable in one’s own skin’ is an idiom referring to one’s confidence in interacting with others. However, when the skin is inflamed, as in atopic dermatitis or psoriasis, patients carry a sub-stantial burden leading to opposite effects. Current therapies target redundant, late-stage inflammatory events but not the disease drivers, leading to heterogeneous and insufficient efficacy. Understanding the proximal mechanisms of inflammation will stimulate the development of better therapi",{"id":722,"funder":7,"programme":8,"title":723,"piName":10,"institution":724,"country":176,"year":13,"amount":725,"abstract":726},"cordis-european-research-council-award-101096688","A Primitive solar Atmosphere around The young Earth?","UNIVERSITE D'ORLEANS","€2,784,505","The existence of an atmosphere enriched in H and He around the Earth as it formed has often been proposed. One hypothesis suggests that it could have been captured from the gas present in the proto-planetary disk, before its evaporation. Subsequently, a secondary atmosphere would have been degassed or brought in by a late veneer of chondritic\u002Fcometary material. Although this model is regularly evoked using giant planets for comparison, there is no geological proof for its existence, except possi",{"id":728,"funder":7,"programme":8,"title":729,"piName":10,"institution":84,"country":85,"year":13,"amount":730,"abstract":731},"cordis-european-research-council-award-101097835","Intermediation and Trust in the Regulatory State: More Regulation, Less Trust?","€2,499,625","Regulation is sometimes a manifestation of distrust, but on other times it is a manifestation of trust. When do trust and regulation compete, substitute for and mutually-support each other? How can we maximize the benefits of both? Is the proliferation of rules around us a manifestation of growing distrust or trust? Is the regulatory state necessarily a low-trust state? To answer these questions, RegTrust introduces intermediation as a governance mechanism and intermediaries as third parties in ",{"id":733,"funder":7,"programme":8,"title":734,"piName":10,"institution":735,"country":242,"year":13,"amount":736,"abstract":737},"cordis-european-research-council-award-101096999","Data Spaces: Making Sense of Health in an Age of Cross-Border Data Infrastructures","KOBENHAVNS UNIVERSITET","€2,499,060","DataSpace proposes a new conceptualization of how the pursuit of health is shaped by data. Healthcare is increasingly datafied and a wide range of actors – patients, clinicians, administrators, policymakers and industry – want to be able to exchange and access health data across national boundaries. Competing initiatives for fostering cross-border data integration proliferate, and the EU provides major investments, e.g. through the European Health Data Space. These massive investments will influ",{"id":739,"funder":7,"programme":8,"title":740,"piName":10,"institution":741,"country":12,"year":13,"amount":67,"abstract":742},"cordis-european-research-council-award-101093186","Semantics of Software Systems","CISPA - HELMHOLTZ-ZENTRUM FUR INFORMATIONSSICHERHEIT GGMBH","*What if we had software bots that tirelessly test, debug, and monitor our software systems?*IT workers are expensive and scarce. So why can't we further automate boring, repetitive activities such as testing and debugging? The problem is that we lack computer-readable _specifications_ (so-called _oracles_) for what the system should do or not do. For decades, this _oracle problem_ has been a roadblock to automated test generation, trusted software repairs, and accurate monitoring of software. B",{"id":744,"funder":7,"programme":8,"title":745,"piName":10,"institution":746,"country":302,"year":13,"amount":747,"abstract":748},"cordis-european-research-council-award-101096793","Dissecting the Brain Basis of Obesity-Induced Pubertal Alterations: A View to a Kiss","UNIVERSIDAD DE CORDOBA","€2,499,995","Child obesity is a worrying condition, affecting 20% adolescents. Among its comorbidities, early obesity is linked to disturbed puberty, which is more evident in girls, but bound to adverse health outcomes in both sexes. Yet, how our brain decodes nutritional info to finely control puberty remains unsolved. Genetic data suggest obesity is largely an hypothalamic disease. Puberty is also hypothalamic-driven and governed by complex neuronal circuits. Among them, Kiss1 neurons have emerged as key e",{"id":750,"funder":7,"programme":8,"title":751,"piName":10,"institution":752,"country":12,"year":13,"amount":753,"abstract":754},"cordis-european-research-council-award-101095857","From conformal symmetries and integrability to the Electron-Ion Collider","UNIVERSITY OF HAMBURG","€2,264,563","The primary goal of this research proposal is to lay the foundations for precision predictions for the physics program in deep-inelastic scattering (DIS) at the Electron-Ion-Collider (EIC). The commissioning of the EIC will open a new era in the exploration of the strong interaction physics and the hadron structure at an unprecedented level of detail. This is expected to lead, among other results, to the clarification of the proton spin puzzle. The crucial ingredient for the success of this unde",{"id":756,"funder":7,"programme":8,"title":757,"piName":10,"institution":758,"country":47,"year":13,"amount":759,"abstract":760},"cordis-european-research-council-award-101098332","Artificial Intelligence and Competition","LUISS LIBERA UNIVERSITA INTERNAZIONALE DEGLI STUDI SOCIALI GUIDO CARLI","€1,877,793","AI algorithms are increasingly being used in markets. It is generally agreed that they create a wealth of value by facilitating economic interactions. However, there are also concerns that when applied to market environments, they could lessen competition and harm consumers. This proposal sets forth an important first step of an articulated research program on AI and Competition. The proposal is structured as three organic projects focusing on two important classes of AI algorithms. The first cl",{"id":762,"funder":7,"programme":8,"title":763,"piName":10,"institution":764,"country":176,"year":13,"amount":10,"abstract":765},"cordis-european-research-council-award-101097884","Theory of Tone","INSTITUT NATIONAL DES LANGUES ET CIVILISATIONS ORIENTALES","Tonal languages are no longer perceived as exotic. According to modern concepts, about 50-60% of the world's languages are tonal. However, the main shortcoming of the majority of research dedicated to tones consists in a narrow panorama of research. It is most often limited either to the description of the tonal system of a certain language or to a particular problem, like correlation of tone and accent, etc. The goal of the project is twofold: (a) to prove that any tonal system can be classifie",{"id":767,"funder":7,"programme":8,"title":768,"piName":10,"institution":392,"country":85,"year":13,"amount":67,"abstract":769},"cordis-european-research-council-award-101097788","The Silent Phase of Alzheimer’s Disease: From Brain States to Homeostatic Failures","Neuronal circuits must balance stability and plasticity. How this balance is compromised in brain disorders remains one of the most fundamental questions in neuroscience. Pioneering studies in the field established that homeostatic mechanisms stabilize the function of a system at a set-point level of activity. Recently, we have identified bona fide mitochondrial regulator of activity set points and provided support to our standing hypothesis that homeostatic failures destabilize network activity",{"id":771,"funder":7,"programme":8,"title":772,"piName":10,"institution":589,"country":20,"year":13,"amount":67,"abstract":773},"cordis-european-research-council-award-101097433","Ultimate fracture toughness through thickness engineering","The design of critical structural metallic components in the aeronautic, biomedical, nuclear or pipeline fields is often dictated by a fail-safe criterion established in the context of fracture mechanics. The design must prevent any pre-existing crack to propagate under nominal but also sometimes accidental loads. In this context, the primary material property is the fracture toughness quantifying the resistance to crack initiation. In ductile metals, the fracture toughness depends on plate thic",{"id":775,"funder":7,"programme":8,"title":776,"piName":10,"institution":314,"country":315,"year":13,"amount":777,"abstract":778},"cordis-european-research-council-award-101097198","Geometric Methods in Inverse Problems for Partial Differential Equations","€2,498,644","Inverse problems are a research field at the intersection of pure and applied mathematics. The goal in inverse problems is to recover information from indirect, incomplete or noisy observations. The problems arise in medical and seismic imaging where measurements made on the exterior of a body are used to deduce the properties of the inaccessible interior. We use mathematical methods ranging from microlocal analysis of partial differential equations and metric geometry to stochastics and computa",{"id":780,"funder":7,"programme":8,"title":781,"piName":10,"institution":101,"country":85,"year":13,"amount":782,"abstract":783},"cordis-european-research-council-award-101096020","Biomimetic eXtremely-Birefringent Organic Optical Materials and devices","€2,473,806","Man-made organic optics relies almost exclusively on amorphous polymers. These cheap, readily processable and highly versatile materials, however, offer a relatively low refractive index, dramatically limiting their ability to generate the high-index contrast necessary for producing scattering layers, photonic crystals and efficient dielectric reflectors. We here propose to establish a new class of novel organic crystalline optical materials and devices by drawing inspiration from the highly bir",{"id":785,"funder":7,"programme":8,"title":786,"piName":10,"institution":787,"country":713,"year":13,"amount":788,"abstract":789},"cordis-european-research-council-award-101095860","Oncolipidomics: Why is lipidomic dysregulation pattern in blood similar for various cancers?","UNIVERZITA PARDUBICE","€3,499,413","Lipids are involved in numerous pathways of human metabolism that are related to pathological states. Alterations of lipid concentrations in the blood of cancer patients have been reported but the biological origin is still unknown. Deciphering the mechanisms of the lipid dysregulation mechanism could dramatically change oncology because it can open new avenues for cancer detection with subsequent effective treatment and drug development targeting dysregulated pathways. Early cancer diagnosis is",{"id":791,"funder":7,"programme":8,"title":792,"piName":10,"institution":101,"country":85,"year":13,"amount":793,"abstract":794},"cordis-european-research-council-award-101092725","A Native Mass Spectrometry Systemic View  of Cellular Structural Biology","€2,954,167","Protein structure and consequently function is influenced by the cellular content. The array of splice variants, post-translational modifications, cleavages and the ability to bind cofactors and drugs, is governed by the surrounding cellular milieu. This is determined by internal and external cues such as cell type, developmental stage, stress conditions, disease and aging, which give rise to an ensemble of distinct protein entities. To study this diversity, there is a need for methods that enab",{"id":796,"funder":7,"programme":8,"title":797,"piName":10,"institution":798,"country":12,"year":13,"amount":799,"abstract":800},"cordis-european-research-council-award-101098243","Ultrafast Picoscopy of Solids","UNIVERSITAET ROSTOCK","€2,499,000","Material science, quantum chemistry, electrical and quantum engineering in the 21st century focus on manipulating and harnessing the properties of matter at the level of atoms and electrons. Advancing these technological capabilities to their ultimate limit calls for novel imaging techniques that can allow us to peer into matter at the level of valence electrons and follow their dynamics in space (tens of picometers) and time (femtosecond to attoseconds).  Here we propose the development and use",{"id":802,"funder":7,"programme":8,"title":803,"piName":10,"institution":804,"country":12,"year":13,"amount":67,"abstract":805},"cordis-european-research-council-award-101097878","Challenging the fundamental limit of angular dispersion by hybridizing light and matter","UNIVERSITAT ZU KOLN","Interference is one of the most fundamental phenomena in optics, allowing us to confine, filter, manipulate and steer light with exquisite precision. It is at the core of thin-film optics and nanophotonics, two areas of science that catalyse major scientific and industrial advances. One fundamental property of optical interference, however, constitutes a major limitation – the characteristics of any interference-based structure depend on the angle between the light wave and the structure itself ",{"id":807,"funder":7,"programme":8,"title":808,"piName":10,"institution":427,"country":12,"year":13,"amount":809,"abstract":810},"cordis-european-research-council-award-101054957","Learning and modeling the molecular response of single cells to drug perturbations","€2,497,298","Advances in single-cell genomics (SCG) allow us to read out a cell’s molecular state with unprecedented detail, increasingly so across perturbations. To fully understand a cellular system, one must be able to predict its internal state in response to all perturbations. Yet such modeling in SCG is currently limited to descriptive statistics. Building upon my expertise in machine learning, I propose to systematically model a cell’s behavior under perturbation, focusing on the largely untouched are",{"id":812,"funder":7,"programme":8,"title":813,"piName":10,"institution":101,"country":85,"year":13,"amount":814,"abstract":815},"cordis-european-research-council-award-101097867","Molecular Mechanisms for Construction of Protective Mucus Hydrogels","€2,162,383","Our bodies produce copious mucus daily to shield vulnerable epithelial cell surfaces in the lungs, intestines, and other organs. Mucus is crucial for defense against pathogens and other environmental hazards, but the mechanisms by which mucus hydrogels assemble and execute their functions are poorly understood. The main obstacle has been that the enormous, heavily glycosylated, and flexible mucin proteins constituting mucus are not readily amenable to structural and molecular approaches. However",{"id":817,"funder":7,"programme":8,"title":818,"piName":10,"institution":819,"country":820,"year":13,"amount":821,"abstract":822},"cordis-european-research-council-award-101096554","Phylogenies probing Grammar. Exploring morphosyntax at different scales of language change","IDRYMA TECHNOLOGIAS KAI EREVNAS","EL","€2,499,925","Morphosyntactic properties have long been considered a great challenge for the reconstruction of language history. On the one hand, they can establish deep genealogical relationships because they remain stable for millennia and evolve slowly in time, serving as markers for families. On the other hand, they may emerge abruptly as a result of borrowing from one language to the other or language restructuring under contact. At the same time, grammars develop common properties independently of histo",{"id":824,"funder":7,"programme":8,"title":825,"piName":10,"institution":826,"country":40,"year":13,"amount":67,"abstract":827},"cordis-european-research-council-award-101098372","Advanced human models of the heart to understand cardiovascular disease","UNIVERSITEIT TWENTE","Cardiovascular diseases (CVD) are the cause of the highest mortality and morbidity rates worldwide and are expected to increase in coming years, leading to epidemic proportions. Traditional experimental in vitro and animal models are not predictive enough, which hampers the emergence of novel therapies for treatment of CVD. Consequently, there is an urgent need to establish realistic human models that lead to a better understanding of CVD, providing the opportunity to identify and validate drugg",{"id":829,"funder":7,"programme":8,"title":830,"piName":10,"institution":308,"country":40,"year":13,"amount":67,"abstract":831},"cordis-european-research-council-award-101097907","Niels Bohr for the 21st Century","Niels Bohr has been hugely influential both in physics and outside physics, but he is also hugely misunderstood, partly because a few of his writings have been overstudied at the expense of many others. This ERC project is devoted to his philosophical legacy, and will establish an unprejudiced understanding of Bohr, building on a current revival of interest in Bohrs ideas in the philosophy of physics, and extending it among other things to his wider influence in other scientific disciplines, spe",{"id":833,"funder":7,"programme":8,"title":834,"piName":10,"institution":835,"country":47,"year":13,"amount":836,"abstract":837},"cordis-european-research-council-award-101098102","Digital Latin Dialectology (DiLaDi): Tracing Linguistic Variation in the Light of Ancient and Early Medieval Sources","UNIVERSITA CA' FOSCARI  VENEZIA","€2,337,500","DiLaDi is an interdisciplinary project that aims to perform a novel comprehensive study on the variation of the Latin Language over the 1st millennium A.D. considering the geographical and chronological perspectives as well as the transition from Latin to Romance by processing and analysing textual errors (deviations from the norm) of ancient and early medieval primary documents with the help of the Computerized Historical Linguistic Database of Latin Inscriptions of the Imperial Age (LLDB) that",{"id":839,"funder":7,"programme":8,"title":840,"piName":10,"institution":841,"country":47,"year":13,"amount":842,"abstract":843},"cordis-european-research-council-award-101093897","Data-Driven Bioinspired Design of Fatigue Super-Resistant Structures: learning by Nature and Flying into the future","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","€2,499,811","Biological material science is a new research topic at the interface of biology and physical science, having a common ground in chemistry, physics, mechanics and engineering. During their evolution, biological materials have developed a unique combination of properties to fulfil specific functions through a series of ingenious and distinctive design elements, evident in different systems created by nature. As an example, butterfly wings have an extraordinary combination of lightness, durability ",{"id":845,"funder":7,"programme":8,"title":846,"piName":10,"institution":143,"country":20,"year":13,"amount":847,"abstract":848},"cordis-european-research-council-award-101098331","Targeting of glycosylation pathways to empower CAR-T therapy of solid tumors.","€2,498,435","Chimeric Antigen Receptor (CAR) T cell therapy uniquely can provide life-long protection against tumor re-emergence upon clearance of even advanced-stage leukemia. However, for the more frequent solid tumor types (carcinomas, lymphomas), clearance of advanced-stage tumors, and especially the subsequent long-term protection, is only rarely achieved. The main reason for this is the multi-pathway immunosuppressive environment that these tumors evolve to overcome the selective pressure imposed by th",{"id":850,"funder":7,"programme":8,"title":851,"piName":10,"institution":735,"country":242,"year":13,"amount":852,"abstract":853},"cordis-european-research-council-award-101095820","Mathematics of Bose-Einstein Condensation","€2,198,091","We propose a project in mathematics with a focus on many-body theory in mathematical physics. We are especially interested in themathematical tools involved in the description and analysis of the recent experimental realizations of Bose-Einstein Condensation. Itremains one of the most important challenges of mathematical physics to rigorously understand the formation of condensatesin interacting systems. This project aims to address that challenge.Progress on the problem of condensation has been",{"id":855,"funder":7,"programme":8,"title":856,"piName":10,"institution":101,"country":85,"year":13,"amount":857,"abstract":858},"cordis-european-research-council-award-101089714","Scanning multi-modality microscopy of moiré quantum matter","€3,018,750","Moir materials are a treasure of mind-blowing scope of phenomena, much of which is still to be discovered. Along with the great opportunities, perplexing experimental and theoretical challenges arise due to numerous degrees of freedom, strong interactions, instabilities, broad tunability, and high sensitivity to exact global and local parameters like twist angles, strain, alignment, screening, and disorder. As a result, each moir device is a mini-universe with its own laws of physics, which cann",{"id":860,"funder":7,"programme":8,"title":861,"piName":10,"institution":862,"country":302,"year":13,"amount":863,"abstract":864},"cordis-european-research-council-award-101097681","A non-inferiority randomized trial testing an advice of modeA non-inferiority randomized trial testing an advice of moderate drinking pattern versus advice on abstention on major disease and mortality","UNIVERSIDAD DE NAVARRA","€2,498,466","Europeans are the largest alcohol consumers. Policymakers and clinicians are currently perplexed on how to reduce alcohol harms in drinkers, due to contradictory guidelines: abstention is proposed as the healthiest option by many health advocates, stating that there is no safe level of alcohol intake; but most nonrandomized studies found lower all-cause mortality and other outcomes in moderate drinkers than in abstainers among subjects >50 years. However, potential biases may compromise these la",{"id":866,"funder":7,"programme":8,"title":867,"piName":10,"institution":101,"country":85,"year":13,"amount":868,"abstract":869},"cordis-european-research-council-award-101097125","The Quantum Twisting Microscope - revolutionizing quantum matter imaging","€3,344,995","In this work, we propose to build a radically new type of scanning probe microscope – the Quantum Twisting Microscope (QTM) – that will be the first capable of performing local quantum interference measurements at a twistable interface between two quantum materials. The concept, already established in preliminary experiments, is based on a unique tip made of an atomically-thin two-dimensional material. This tip allows electrons to coherently tunnel into a sample at many locations at once, making",{"id":871,"funder":7,"programme":8,"title":872,"piName":10,"institution":621,"country":176,"year":13,"amount":873,"abstract":874},"cordis-european-research-council-award-101097569","Electro-optic frequency comb generation  in the mid-infrared.","€2,426,034","Mid-infrared (mid-IR) spectroscopy is a nearly universal way to identify chemical and biological substances and to perform non-invasive diagnostics. More specifically, the 6-15 m wavelength range can be exploited to detect small traces of environmentally hazardous and toxic substances for a variety of applications including defense, security and industrial monitoring. While current optical systems in the mid-IR range are based on bulky assemblies of discrete devices, a challenging task is to mak",{"id":876,"funder":7,"programme":8,"title":877,"piName":10,"institution":878,"country":40,"year":13,"amount":67,"abstract":879},"cordis-european-research-council-award-101098324","Myopia control in the real world: treatments, target, timing, and terminus","ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM","Background: Myopia, or near-sightedness, is increasing dramatically all over the world, mostly due to higher levels of education and changing lifestyles of young generations. The expectation is that half of the world’s citizens will be myopic by 2050. Myopia-related complications later in life are a serious threat to vision and will increase the rates of blindness. Prevention strategies and pharmacological and optical treatments to delay progression of myopia in childhood are emerging, but most ",{"id":881,"funder":7,"programme":8,"title":882,"piName":10,"institution":883,"country":132,"year":13,"amount":884,"abstract":885},"cordis-european-research-council-award-101092623","Dependence Of NUcleosome Transactions on Sequence","UPPSALA UNIVERSITET","€2,137,145","Eukaryotic genomes are packaged into chromatin, which restricts access to the DNA. Key genomic processes therefore involve the rearrangement of chromatin by ATP-dependent chromatin remodelling enzymes (remodellers), which actively place and reorganise nucleosomes. The precise positioning of nucleosomes plays a crucial role in regulating transcription, replication, and DNA repair. DNA sequence impacts this nucleosome architecture by affecting the activity of remodellers. However, what mechanisms ",{"id":887,"funder":7,"programme":8,"title":888,"piName":10,"institution":78,"country":12,"year":13,"amount":889,"abstract":890},"cordis-european-research-council-award-101096005","Hidden Legacies   How discontinued International Organizations have shaped European governance since the 1910s","€2,497,395","What happens after international organizations (IOs) cease to exist? While IOs ends are occasionally discussed in political science and legal studies, we know very little about the legacy of IOs, and hence the subsequent role and impact of people, ideas, practices and objects (including buildings and budg-ets) that once filled such organizations with life and meaning. InechO hypothesizes that for a full un-derstanding of international history and questions of political governance more broadly, i",{"id":892,"funder":7,"programme":8,"title":893,"piName":10,"institution":571,"country":20,"year":13,"amount":894,"abstract":895},"cordis-european-research-council-award-101098310","''It’s the Symmetry, Stupid!'' Gearing Up Tensor Networks for the  Topological Quantum Revolution","€2,302,500","This proposal is set in the era of the second quantum revolution, in which there is a strong need for a computational framework to describe and simulate topological materials and quantum devices possessing exotic particle statistics.* The two leading actors: symmetries and tensor networks. * The story: while the topological materials seem to defy Landau’s symmetry breaking paradigm as they do not exhibit a local order parameter, tensor networks strike back with the emergence of a local “pulling-",{"id":897,"funder":7,"programme":8,"title":898,"piName":10,"institution":543,"country":12,"year":13,"amount":899,"abstract":900},"cordis-european-research-council-award-101096706","Regulation of the L-arginine – ADMA – Nitric Oxide (NO) Pathway in the Pulmonary Vascular Response to Hypoxia and its Role for Survival of High-Risk COPD Patients","€2,499,927","NO PRESSURE will address the hypothesis that intermittent hypoxaemia is a major driver of the pulmonary pathophysiology and the systemic co-morbidity that is present at a sub-clinical level already in early disease stages of a significant sub-group of COPD patients with a high risk of rapidly declining lung function and poor prognosis. The project has been conceptualized to achieve ground-breaking scientific insight into the role of intermittent hypoxaemia as a driver of COPD progression and out",{"id":902,"funder":7,"programme":8,"title":903,"piName":10,"institution":506,"country":47,"year":13,"amount":904,"abstract":905},"cordis-european-research-council-award-101097752","TARGETING INHERITED CANCER SYNDROMES","€2,496,625","Transcription factors EB and E3 (TFEB and TFE3), members of the MiT-TFE family, are master controllers of lysosomal biogenesis and autophagy. The activity of TFEB and TFE3 is regulated by mechanistic Target Of Rapamycin Complex 1 (mTORC1), a central hub of cell metabolism, which inhibits their cytoplasm-to-nucleus translocation. We recently discovered that mTORC1 phosphorylates TFEB and TFE3 via a non-canonical TORC1 (NC-mTORC1) signaling mechanism, providing the first evidence that mTORC1 can p",{"id":907,"funder":7,"programme":8,"title":908,"piName":10,"institution":475,"country":176,"year":13,"amount":909,"abstract":910},"cordis-european-research-council-award-101098063","Mesoscale organisation of tropical convection","€2,994,634","Recent research has shown that the spatial organisation of convection (and hence clouds) at the mesoscale (20-200km) dramatically affects the Earth’s energy balance and hydrological cycle. This raises the question as to how the organisation of convection will change with warming, and how it will influence the climate. A poor understanding of the physical drivers of the mesoscale organisation of convection, compounded by an inability to simulate and observe such processes, has hampered our abilit",{"id":912,"funder":7,"programme":8,"title":913,"piName":10,"institution":826,"country":40,"year":13,"amount":67,"abstract":914},"cordis-european-research-council-award-101094492","Melting and dissolution across scales in multicomponent systems","Melting and dissolution induce temperature and concentration gradients in liquid systems. These gradients induce flows, namely buoyancy driven flows on large scales and phoretic flows on small scales. Such flows locally enhance or delay the melting or dissolution process and thus determine the objects shape. On large scales, a relevant example for the climate are glaciers and icebergs melting into the ocean, where cold and fresh meltwater experiences buoyant forces against the surrounding ocean ",{"id":916,"funder":7,"programme":8,"title":917,"piName":10,"institution":918,"country":47,"year":13,"amount":919,"abstract":920},"cordis-european-research-council-award-101095974","Nanoscale Epitaxial Heterostructures Involving Metal Halides","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","€2,499,375","Building epitaxial interfaces between two materials that match each other with atomic precision is key to control the flow of electrons in many technological devices spanning electronics, optics and catalysis. Today, these interfaces are realized also with colloidal nanocrystals, for example in the strongly light emitting core\u002Fshell quantum dots used in TV displays. For nanocrystals, the synthesis of epitaxial interfaces based on traditional semiconductors (metal chalcogenides\u002Fpnictides, etc.) i",{"id":922,"funder":7,"programme":8,"title":923,"piName":10,"institution":924,"country":820,"year":13,"amount":67,"abstract":925},"cordis-european-research-council-award-101095721","Continuous Digitalized Processes for Producing Biopharmaceuticals","ARISTOTELIO PANEPISTIMIO THESSALONIKIS","Biopharmaceuticals are essential for the medical treatment of diseases like immune deficiencies, cancer, and diabetes, and provide an indispensable component to the health care system worldwide, as showcased by mRNA vaccines in the recent pandemic. Despite this success, manufacturing is still based on traditional, outdated batch production technologies, and on process development procedures based on historical experience and empiricism leading to many inefficiencies, like very long values of tim",{"id":927,"funder":7,"programme":8,"title":928,"piName":10,"institution":929,"country":12,"year":13,"amount":930,"abstract":931},"cordis-european-research-council-award-101097053","The synaptic active zone as a signaling hub for sleep homeostasis and resilience","FREIE UNIVERSITAET BERLIN","€2,242,580","Resilience designates the ability of the brain to cope with and adapt to stressful situations. Sleep homeostasis is tightly linked to resilience, and the sleep deficits observed alongside neurodegeneration probably operate as direct drivers of neurodegeneration. However, the knowledge gaps still remain huge and causally bridging the molecular\u002Fcellular with the behavioral and organismic level remains a challenge, hampering progress equally for biomedical and basic research.Our recent data suggest",{"id":933,"funder":7,"programme":8,"title":934,"piName":10,"institution":935,"country":132,"year":13,"amount":936,"abstract":937},"cordis-european-research-council-award-101096708","Is there a PERENNIAL future of agriculture?","LUNDS UNIVERSITET","€2,614,373","PERENNIAL will investigate whether a shift from annual to perennial grain crops as the basis for food production is possible, and identify the major opportunities and obstacles for such a “perennial revolution”. Since the Neolithic Revolution the world food system has been dominated by annual crops (cereals, legumes, and oil seeds) covering 70% of global croplands. The use of annual plants disrupts agro-ecological processes every season, resulting in soil erosion, nutrient losses, and greenhouse",{"id":939,"funder":7,"programme":8,"title":940,"piName":10,"institution":101,"country":85,"year":13,"amount":67,"abstract":941},"cordis-european-research-council-award-101097332","Overcoming Resistance to Anti-cancer Drugs by Blocking Mutation-prone DNA Polymerases and the SOS Response","Background: A large fraction of cancer patients die because their tumors initially respond to drugs but later they evolve tolerance. Thus, resistance to diverse drugs, along with the soaring costs of new treatments, are emerging as major societal issues of the 2020s. Herein, we explore one of the most distressful examples, tolerance of lung cancer to EGFR-specific tyrosine kinase inhibitors (TKIs). Working hypothesis: In similarity to bacteria exposed to antibiotics, when cancer cells are expose",{"id":943,"funder":7,"programme":8,"title":944,"piName":10,"institution":945,"country":176,"year":13,"amount":946,"abstract":947},"cordis-european-research-council-award-101097259","Exploration of Unknown Environments for Digital Twins","ECOLE NATIONALE DES PONTS ET CHAUSSEES","€2,476,718","In the 'explorer' project, we will develop methods for automatically capturing and labelling video data in open worlds.  The ultimate goal is the great facilitation of the creation and maintenance of Digital Twins: Digital Twins are virtual 3D copies of complex scenes such as cities, factories, or construction sites.  Not just a 3D reconstruction, they should capture the scene's semantics, i.e.  the identity of each object and the scene's dynamics, i.e.  how objects move.  Because Digital Twins ",{"id":949,"funder":7,"programme":8,"title":950,"piName":10,"institution":72,"country":47,"year":13,"amount":951,"abstract":952},"cordis-european-research-council-award-101097578","Memory, Beliefs, and Economic Decisions","€1,936,400","This project builds on the psychology of memory to study how selective retrieval affects economic decisions by shaping beliefs and preferences. The general approach is one in which a person’s past experiences (both domain relevant and domain irrelevant) determine her “core” beliefs and preferences, but changing cues in the environment ignite selective retrieval of specific pieces of information, causing instability in beliefs and preferences. In this way, selective memory acts as a source of fra",{"id":954,"funder":7,"programme":8,"title":955,"piName":10,"institution":197,"country":20,"year":13,"amount":10,"abstract":956},"cordis-european-research-council-award-101095310","Planetary space simulations based on the particle description for electrons and ions.","The question about how solar storms impact a planet has both fundamental scientific importance and greatsocial impacts for protecting our infrastructure from the most powerful solar storms. At present, models relyon a fluid description of the electrons due to algorithmic and computational challenges. Our goal is to developa model of the space environment around a planet based on a particle description of both ions and electrons.We plan to use the particle in cell (PIC) model where both ions and ",{"id":958,"funder":7,"programme":8,"title":959,"piName":10,"institution":960,"country":164,"year":13,"amount":67,"abstract":961},"cordis-european-research-council-award-101097858","Emergence in Quantum Physics","TECHNISCHE UNIVERSITAET WIEN","Emergence is central to our understanding of the world. It addresses the question of how did a seemingly unlimited diversity emerge from a small number of simple constituents. Ultimately emergence in physics is related to an inaccessibility of knowledge about the microscopic world, out of which new phenomena are formed at a larger scale. In quantum physics the Renormalization Group is a prominent example relating microscopic physics to emerging new phenomena.The main thrust in the research propo",{"id":963,"funder":7,"programme":8,"title":964,"piName":10,"institution":965,"country":119,"year":13,"amount":966,"abstract":967},"cordis-european-research-council-award-101097337","Approaching 20% emission efficiency in the NIR-II region with radical chromophores","INSTITUTE OF ORGANIC CHEMISTRY - POLISH ACADEMY OF SCIENCES","€2,499,825","The applications of light-based technologies in modern society cannot be underestimated. Some well-known examples of these include organic light-emitting diodes, fluorescent sensors, organic photovoltaics and fluorescence imaging. Emissive radicals have recently appeared as promising and entirely new building blocks for these technologies. This breakthrough is due to the fact that their electron spins at the lowest excited state and ground state are both doublets and the transition from the lowe",{"id":969,"funder":7,"programme":8,"title":970,"piName":10,"institution":475,"country":176,"year":13,"amount":971,"abstract":972},"cordis-european-research-council-award-101097272","A holistic approach to bridge the gap between microsecond computer simulations and millisecond biological events","€2,134,529","Complete understanding of how complex biological objects operate and fulfill their cellular role requires at its core a detailed picture of the millisecond (ms) conformational transitions between functional states. Computational investigation of such ms–events is thwarted by our difficulty—and often impossibility—to identify and sample efficiently the relevant degrees of freedom at play, as well as the current limitation of all-atom molecular dynamics to the microsecond (μs) timescale on common ",{"id":974,"funder":7,"programme":8,"title":975,"piName":10,"institution":976,"country":47,"year":13,"amount":977,"abstract":978},"cordis-european-research-council-award-101093572","StarDance: the non-canonical evolution of stars in clusters","ISTITUTO NAZIONALE DI ASTROFISICA","€2,492,250","Thanks to their ubiquity, brightness, and the fact that they are made of stars with similar properties, star clusters have been used as astrophysical laboratories or test particles in an impressive range of research domains. However, we still do not understand fundamental details of their formation and evolution. In spite of recent technological progress, a list of unsolved problems and apparently isolated mysteries has been accumulating over time, some standing since decades.Among them, the exi",{"id":980,"funder":7,"programme":8,"title":981,"piName":10,"institution":982,"country":983,"year":13,"amount":984,"abstract":985},"cordis-european-research-council-award-101098095","Transnational histories of 'corruption' in Central-South-East Europe (1750-1850)","FUNDATIA NOUA EUROPA","RO","€2,494,813","Politicians, scholars, and popular writers between 1750 and 1850 routinely characterized South-East-Central Europe as a corrupt political space. A wide range of foreign observers portrayed graft, nepotism, and bribery as endemic. Indigenous critics echoed many of these assessments. Regional insiders and outsiders alike mobilized commentaries on “corruption” for their own political, professional, and personal ends, claiming they could run more honest and efficient administrations, military regime",{"id":987,"funder":7,"programme":8,"title":988,"piName":10,"institution":589,"country":20,"year":13,"amount":989,"abstract":990},"cordis-european-research-council-award-101096871","Connecting Symmetric and Asymmetric  Cryptography for Leakage and Faults","€2,499,560","Symmetric & asymmetric cryptography offer the basic functionalities needed to communicate securely over a channel. Due to their different features and the different algebraic structures they exploit, the interaction between the design of these primitives and the security of their implementation against side-channel & fault attacks so far followed somewhat separated paths. Based on the observation that (i) many emerging challenges for the implementation security of symmetric & asymmetric primitiv",{"id":992,"funder":7,"programme":8,"title":993,"piName":10,"institution":320,"country":132,"year":13,"amount":994,"abstract":995},"cordis-european-research-council-award-101098334","It’s (also) what you produce: Experimental Evidence on Creating Markets for Quality in Low-income Countries","€2,097,367","Half of the world's extreme poor  or over 430 million people  live in Sub-Saharan Africa. The vast majority live in rural areas and work in agriculture, where productivity is desperately low. This keeps welfare low now  and in the future  as agricultural productivity increases are seen as a condition for both structural transformation and to avoid the worst impacts of climate change. This is the motivation for bringing the green revolution  which has so far bypassed the continent  to Sub-Saharan",{"id":997,"funder":7,"programme":8,"title":998,"piName":10,"institution":999,"country":47,"year":13,"amount":1000,"abstract":1001},"cordis-european-research-council-award-101097740","Global Cleavages: The Shape of Political Conflict across World Regions in Historical Perspective","EUROPEAN UNIVERSITY INSTITUTE","€2,499,931","This project investigates the dimensionality of global politics. It analyses the cleavages that structure world politics and asks whetherconflicts are shaped territorially or along functional dimensions cutting across world regions. The question of whether individualsworldwide are opposed territorially or according to socio-economic and cultural groups is addressed in a long-term empirical analysisspanning historical phases from the 19th century to the present. The goal is to establish if, and u",{"id":1003,"funder":7,"programme":8,"title":1004,"piName":10,"institution":1005,"country":302,"year":13,"amount":10,"abstract":1006},"cordis-european-research-council-award-101098241","STEM CELL PLASTICITY IN ADULT NEUROGENIC NICHES","UNIVERSITAT DE VALENCIA","Somatic stem cells (SCs) sustain tissue renewal and regeneration in adult mammals. The maintenance of their stemness and long-lasting preservation in cohabitation with differentiated progeny at specific niches poses these cells to a considerable challenge. To deal with it, SCs display a complex network of yet to be fully uncovered mechanisms that allow multilevel plasticity. Cellular plasticity indicates the ability of cells to reversibly change their phenotype in response to the microenvironmen",{"id":1008,"funder":7,"programme":8,"title":1009,"piName":10,"institution":1010,"country":1011,"year":13,"amount":1012,"abstract":1013},"cordis-european-research-council-award-101096403","N2O Budgets in Peatlands - from Process to Ecosystem","TARTU ULIKOOL","EE","€3,498,875","Nitrous oxide (N2O) is a powerful greenhouse gas and dangerous stratospheric O3 depleting agent. Agriculture and forestry in peatlands are the main sources of N2O emissions. Climate extreme events may boost the emissions but knowledge on their effect is scarce. N2O is a product of a variety of soil processes, including denitrification, nitrification and less studied mechanisms. Partitioning of N2O fluxes between all these different mechanisms is still a major challenge. Microbial processes are o",{"id":1015,"funder":7,"programme":8,"title":1016,"piName":10,"institution":475,"country":176,"year":13,"amount":1017,"abstract":1018},"cordis-european-research-council-award-101097182","Percolation and conductivity in fluids containing rod-like particles","€2,458,750","The PERLA project aims at developing electrically conductive fluids containing rod-like particles. Their novelty is based on the formation of dynamical system-spanning networks in fluid flow. It is well established that rod-like particles do not simply align, but do tumble and rotate in shear or elongational flow. However, the consequences of this tumbling on the percolation and electrical conductivity of suspensions are still unknown. This behaviour is expected to promote collisions and electri",{"id":1020,"funder":7,"programme":8,"title":1021,"piName":10,"institution":101,"country":85,"year":13,"amount":67,"abstract":1022},"cordis-european-research-council-award-101094980","An integrative genetic approach for the exploration of melanoma immunological interactions","Immunotherapy, which has revolutionized cancer treatment, largely relies on the immune system’s recognition of neopeptides, degradation products of altered proteins specific to cancer cells presented on their surface. In particular, cancer vaccines targeting neopeptides have shown promising clinical results. Yet, to optimize their efficacy and broaden their application, we need to decipher the nature of the cancer peptide landscape (immunopeptidome) and delineate the neopeptide properties requir",{"id":1024,"funder":7,"programme":8,"title":1025,"piName":10,"institution":1026,"country":302,"year":13,"amount":1027,"abstract":1028},"cordis-european-research-council-award-101097816","Giving Voice to Hispanic Chant through a Phylogenetic Study of Medieval Plainchant","UNIVERSIDAD COMPLUTENSE DE MADRID","€2,499,500","Plainchant, the sacred Christian chant, is the most ancient Western corpus preserved in musical notation. Before the unifying adoption of the Gregorian liturgy throughout Europe in the 9th century, a number of liturgical families each one with its own chant repertoire emerged in the ancient Western Roman provinces. Among them, the Hispanic liturgy was recorded text and music in manuscripts between ca. 700 and ca. 1300. These sources allow us to know the liturgys ceremonies and texts, but not the",{"id":1030,"funder":7,"programme":8,"title":1031,"piName":10,"institution":314,"country":315,"year":13,"amount":1032,"abstract":1033},"cordis-european-research-council-award-101094124","Material and environmental legacies in the 21st century: a theory of legacy-making between generations","€2,498,766","Human legacies are more important and influential than ever before because the window of opportunity for generational interaction has been greatly extended due to longer life expectancies, and because legacies assume unprecedented importance in a world marked by inequality and environmental degradation. The LEGACIES project arises from my original proposition that legacies are not only posthumous and concern older people and their heirs, but they are dynamic intergenerational processes comprisin",{"id":1035,"funder":7,"programme":8,"title":1036,"piName":10,"institution":475,"country":176,"year":13,"amount":1037,"abstract":1038},"cordis-european-research-council-award-101096017","The Global Latent Workspace: towards AI models of flexible cognition","€2,499,366","Recent advances in deep learning have allowed Artificial Intelligence (AI) to reach human-level performance in many sensory, perceptual, linguistic or cognitive tasks. There is a growing need, however, for novel, brain-inspired cognitive architectures to achieve more robust and flexible cognition. The Global Workspace Theory refers to a large-scale system integrating and distributing information among networks of specialized modules to create higher-level forms of cognition and awareness. It is ",{"id":1040,"funder":7,"programme":8,"title":1041,"piName":10,"institution":392,"country":85,"year":13,"amount":1042,"abstract":1043},"cordis-european-research-council-award-101097998","The Jewish Library in Late Antiquity: Forgotten Texts and Non-Rabbinic Jews","€2,308,896","In the study of ancient Judaism, a debate has been raging over the place of the rabbinic movement in late antique Jewish society. On the one hand, there is the extensive body of rabbinic literature, which has much to say about the rabbis own world, and relatively little to say about non-rabbinic Jews, thus creating the impression that the rabbis were the only significant social factor in late antique Jewish society. On the other hand, there is an impressive, and constantly growing, body of archa",{"id":1045,"funder":7,"programme":8,"title":1046,"piName":10,"institution":1047,"country":12,"year":13,"amount":1048,"abstract":1049},"cordis-european-research-council-award-101098006","FAME: OPEN-ENDED MANIPULATION TASK LEARNING WITH FAME (FUTURE-ORIENTED COGNITIVE1 ACTION MODELLING ENGINE)","UNIVERSITAET BREMEN","€2,499,063","The realization of computational models for accomplishing everyday manipulation tasks for any object and any purpose would be adisruptive breakthrough in the creation of versatile, general-purpose robot agents; and it is a grand challenge for AI and robotics.Humans are able to accomplish tasks such as “cut up the fruit” for many types of fruit by generating a large variety of context-specificmanipulation behaviors. They can typically accomplish the tasks on the first attempt despite uncertain ph",{"id":1051,"funder":7,"programme":8,"title":1052,"piName":10,"institution":191,"country":12,"year":13,"amount":1053,"abstract":1054},"cordis-european-research-council-award-101096948","Sensing Aberrant Transcription by MYC Multimers","€2,498,471","Deregulated expression of MYC or one of its paralogues, MYCN and MYCL, maintains the growth of most human tumors. All current models explain the oncogenic potential of MYC proteins by their ability to form complexes with MAX that universally bind to active promoters and the ability of these complexes to induce a tumor-specific gene expression pattern. While MYC conforms to this model during unperturbed cell growth, we have discovered two paradigmatic situations in which MYC proteins undergo fund",{"id":1056,"funder":7,"programme":8,"title":1057,"piName":10,"institution":883,"country":132,"year":13,"amount":1058,"abstract":1059},"cordis-european-research-council-award-101097763","African Literary Metadata","€2,317,848","Recent years have seen something of a renaissance in African literature, with African novelists becoming global best-sellers and achieving the world’s highest literary accolades. But published novels are restrictively expensive in Africa itself and the novel form is ill-suited to African everyday life, where people are more likely to spend their leisure time engaging with informal, ephemeral and not-for-profit literary and oratory cultural forms, such as spoken-word poetry, street theatre, and a",{"id":1061,"funder":7,"programme":8,"title":1062,"piName":10,"institution":1063,"country":40,"year":13,"amount":1064,"abstract":1065},"cordis-european-research-council-award-101097983","Bioactive lipids Regulate Adaptive Immune responses in Neurodegeneration: novel target for treatment?","STICHTING AMSTERDAM UMC","€2,499,686","Traditionally, AD is regarded as a neurodegenerative disease and as such, the major focus has been on investigating and treating neurodegeneration and neuronal functioning. Only the last decade, it became apparent that AD pathogenesis strongly interferes with immunological processes and vice versa. Indeed, my novel findings show that the immune system in patients with early AD is already severely derailed and highlight a specific role for CD8+ T-cells. My exciting data also suggest the importanc",{"id":1067,"funder":7,"programme":8,"title":1068,"piName":10,"institution":1069,"country":176,"year":13,"amount":10,"abstract":1070},"cordis-european-research-council-award-101097984","SafE and reliabLE COmbustion Technologies powered by Hydrogen","UNIVERSITE DE TOULOUSE","Hydrogen is uniquely placed to achieve both energy security and net-zero greenhouse emission goals provided it can be produced by low-carbon resources and systems powered by hydrogen can be operated safely and reliably. Hydrogen can be burned to produce heat or power. It can also be used in fuel cells to produce electricity. Due to its high reactivity with oxygen, it often results in violent dynamics that raises challenges to guarantee the integrity and reliability of the systems powered by hydr",{"id":1072,"funder":7,"programme":8,"title":1073,"piName":10,"institution":1074,"country":1075,"year":13,"amount":67,"abstract":1076},"cordis-european-research-council-award-101095997","Eco-Evolutionary Rescue of Fragmented Populations","NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU","NO","Here I will establish eco-evolutionary rescue analyses as a predictive science. I will do this by developing theories, principles and tools for assessing whether populations can cope with changes in the environment at both short (ecological) and long (evolutionary) timescales. I contend that analyses involving the capacity of organisms to adapt to environmental changes must be based on theories including realistic ecological assumptions. My aim is therefore to develop a common theoretical framew",{"id":1078,"funder":7,"programme":8,"title":1079,"piName":10,"institution":475,"country":176,"year":13,"amount":1080,"abstract":1081},"cordis-european-research-council-award-101097842","Cohesion in Particulate media","€2,469,604","How grains flow? Can we predict the behavior of sand, snow, powders and more generally of a collection of particles? In many situations both in nature or industry, this question is of importance to predict avalanches, landslides, or designing silos and industrial processes. While for simple fluids the measure of the viscosity is sufficient to compute and predict the flow, for granular materials the question remains open. The challenge of understanding the physics of granular flows has motivated ",{"id":1083,"funder":7,"programme":8,"title":1084,"piName":10,"institution":1085,"country":40,"year":13,"amount":1086,"abstract":1087},"cordis-european-research-council-award-101095973","A double-edged sword: extra-galactic Fast X-ray Transients","STICHTING RADBOUD UNIVERSITEIT","€3,000,000","We will use extra-galactic Fast X-ray Transients (FXTs) to study binary neutron star (BNS) mergers. Merging neutron stars are important for the formation of r-process elements and provide standardizable signals allowing the Hubble constant (H0) to be measured maximizing the science output of these multi-messenger events. Comparing BNS mergers with and without an FXT signal provides a way to constrain the elusive equation of state of matter at supra-nuclear densities. Unlike the highly beamed sho",{"id":1089,"funder":7,"programme":8,"title":1090,"piName":10,"institution":1091,"country":302,"year":13,"amount":656,"abstract":1092},"cordis-european-research-council-award-101097753","Engineering synthetic mechanotransduction through nucleocytoplasmic transport","FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA","Our understanding of cell biology has reached the point in which cells can be exogenously engineered to carry out specific tasks. This is typically applied to generate gene circuits that respond to biochemical interactions between specific molecules. However, cells sense not only biochemical but also mechanical signals, in the process of mechanotransduction. Here, we propose to re-engineer cell mechanotransduction from scratch, in a manner that is not based on any endogenous cell signalling path",{"id":1094,"funder":7,"programme":8,"title":1095,"piName":10,"institution":1096,"country":47,"year":13,"amount":1097,"abstract":1098},"cordis-european-research-council-award-101095012","X-ray spectroscopy of molecular chirality in solutions","ELETTRA - SINCROTRONE TRIESTE SCPA","€2,474,813","The purpose of this proposal is to implement X-ray circular and helical dichroism to investigate the structure and chemical dynamics of molecular systems in solution. The proposal entails first establishing the concepts and observables of X-ray dichroism in steady-state studies both in the soft and hard X-ray ranges, and then implementing time-resolved X-ray circular and helical dichroism spectroscopies as probes of the chemical dynamics.",{"id":1100,"funder":7,"programme":8,"title":1101,"piName":10,"institution":1102,"country":176,"year":13,"amount":1103,"abstract":1104},"cordis-european-research-council-award-101096550","Integrating Spectral and Geometric data on Moduli Space","UNIVERSITE DE STRASBOURG","€1,686,575","Each physical object possesses specific frequencies of vibrations, called its eigenfrequencies, at which it enters in resonance under an external stimulus. In mathematical terms these frequencies are the eigenvalues of a linear operator; they form the spectrum of the object. Spectral geometry is concerned with understanding how the spectrum of an object, as well as the modes of vibration (eigenfunctions) associated to each eigenfrequency, are related to its geometric shape. This is a wide area o",200,{"programme":8,"total":1107,"withPiName":1108,"firstYear":1109,"lastYear":1110,"countryCount":1111,"perYear":1112,"topInstitutions":1169,"topCountries":1240},4756,450,2008,2027,46,[1113,1115,1118,1121,1124,1127,1130,1133,1136,1139,1141,1144,1147,1150,1153,1156,1158,1161,1164,1167],{"year":1109,"count":1114},47,{"year":1116,"count":1117},2009,232,{"year":1119,"count":1120},2010,248,{"year":1122,"count":1123},2011,276,{"year":1125,"count":1126},2012,293,{"year":1128,"count":1129},2013,344,{"year":1131,"count":1132},2014,359,{"year":1134,"count":1135},2015,138,{"year":1137,"count":1138},2016,299,{"year":1140,"count":1117},2017,{"year":1142,"count":1143},2018,376,{"year":1145,"count":1146},2019,241,{"year":1148,"count":1149},2020,137,{"year":1151,"count":1152},2021,228,{"year":1154,"count":1155},2022,322,{"year":13,"count":1157},252,{"year":1159,"count":1160},2024,243,{"year":1162,"count":1163},2025,222,{"year":1165,"count":1166},2026,264,{"year":1110,"count":1168},3,[1170,1173,1176,1179,1182,1185,1188,1191,1194,1197,1200,1203,1206,1209,1212,1215,1218,1221,1223,1226,1228,1230,1232,1235,1237],{"name":1171,"count":1172},"Centre National de la Recherche Scientifique CNRS",206,{"name":1174,"count":1175},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",133,{"name":1177,"count":1178},"University of Oxford",128,{"name":1180,"count":1181},"University of Cambridge",124,{"name":1183,"count":1184},"Eidgenoessische Technische Hochschule Zuerich",84,{"name":1186,"count":1187},"Weizmann Institute of Science",74,{"name":1189,"count":1190},"École Polytechnique Fédérale de Lausanne",72,{"name":1192,"count":1193},"University College London",69,{"name":1195,"count":1196},"Ludwig-Maximilians-Universitaet Muenchen",59,{"name":1198,"count":1199},"The Hebrew University of Jerusalem",57,{"name":1201,"count":1202},"Katholieke Universiteit Leuven",52,{"name":1204,"count":1205},"University of Bristol",49,{"name":1207,"count":1208},"University of Edinburgh",48,{"name":1210,"count":1211},"Kobenhavns Universitet",40,{"name":1213,"count":1214},"Universiteit van Amsterdam",39,{"name":1216,"count":1217},"Institut National de la Sante Et de la Recherche Medicale",38,{"name":1219,"count":1220},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",35,{"name":1222,"count":1220},"Tel Aviv University",{"name":1224,"count":1225},"Imperial College of Science Technology and Medicine",33,{"name":1227,"count":1225},"Technische Universitaet Muenchen",{"name":1229,"count":1225},"Universitat Wien",{"name":1231,"count":1225},"University of Manchester",{"name":1233,"count":1234},"Helsingin Yliopisto",32,{"name":1236,"count":1234},"Karolinska Institutet",{"name":1238,"count":1239},"Technische Universiteit Delft",30,[1241,1243,1246,1248,1250,1253,1255,1257,1259,1261,1263,1264,1266,1269,1271,1273,1275,1276,1278,1280,1283,1285,1287,1288,1291],{"name":12,"count":1242},802,{"name":1244,"count":1245},"UK",778,{"name":176,"count":1247},581,{"name":40,"count":1249},390,{"name":1251,"count":1252},"CH",310,{"name":47,"count":1254},302,{"name":302,"count":1256},269,{"name":85,"count":1258},202,{"name":132,"count":1260},183,{"name":164,"count":1262},153,{"name":20,"count":1262},{"name":242,"count":1265},107,{"name":1267,"count":1268},"GB",78,{"name":315,"count":1270},76,{"name":1075,"count":1272},65,{"name":235,"count":1274},42,{"name":96,"count":1211},{"name":54,"count":1277},25,{"name":820,"count":1279},24,{"name":1281,"count":1282},"US",20,{"name":119,"count":1284},18,{"name":713,"count":1286},15,{"name":33,"count":1286},{"name":1289,"count":1290},"CN",9,{"name":1011,"count":1292},8]