[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-advanced-grant-2024":3,"awarded-stats-erc-advanced-grant":1116},{"awarded":4,"total":1115},[5,16,22,29,36,43,50,55,62,69,75,80,87,93,100,106,110,116,122,128,135,141,146,151,157,163,169,176,181,187,193,197,203,208,215,220,225,232,238,244,250,256,263,268,273,278,284,289,295,300,304,309,313,318,324,329,334,339,345,352,358,364,370,375,379,383,387,391,397,402,407,413,419,424,429,435,440,445,450,455,461,466,472,477,482,487,493,497,502,507,513,519,524,530,536,541,547,553,559,565,571,575,581,587,593,598,602,607,613,618,623,627,633,638,644,650,655,660,666,672,678,683,688,694,699,703,708,713,719,725,730,736,742,748,754,761,767,772,778,785,791,796,800,806,811,817,823,828,834,839,845,850,854,859,864,870,875,880,886,891,897,903,909,914,921,926,931,937,942,946,951,956,963,968,972,978,984,990,996,1002,1007,1012,1017,1021,1027,1033,1039,1045,1051,1057,1062,1067,1072,1077,1081,1086,1091,1097,1103,1109],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-101140637","European Research Council","ERC Advanced Grant","Spatio-Seasonal Eco-Evolutionary Dynamics",null,"NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU","NO",2024,"€2,499,752","My overarching ambition in EcoEvoMove is to provide new theoretical and empirical understanding of how ecological and evolutionary dynamics can interact to ‘rescue’ wild populations from impending extinctions caused by changing and increasingly extreme seasonal climatic conditions.Seasonal climates are rapidly changing, but capabilities to predict real-world population responses are still severely limited. Major problems are that 1) existing eco-evolutionary theory relies on core assumptions tha",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":12,"year":13,"amount":20,"abstract":21},"cordis-european-research-council-award-101141494","The Division of Labor in Production Networks","STIFTELSEN HANDELSHOYSKOLEN BI","€2,277,400","The division of labor - breaking down work into tasks so that workers can specialize in a subset of tasks - is believed by many economists to be key to economic progress, by providing efficiency gains when producing goods and services. A key feature of the modern economy is that the division of labor is increasingly taking place between firms - in a production network - as firms fragment production along the supply chain, both within and across borders (Johnson and Noguera, 2017). This project a",{"id":23,"funder":7,"programme":8,"title":24,"piName":10,"institution":25,"country":26,"year":13,"amount":27,"abstract":28},"cordis-european-research-council-award-101140741","Collective Adaptation","COMPLEXITY SCIENCE HUB VIENNA CSH - VEREIN ZUR FOERDERUNG WISSENSCHAFTLICHER FORSCHUNG IM BEREICH KOMPLEXER SYSTEME","AT","€3,096,966","Human collectives adapt their cognitive strategies and social networks flexibly in response to multiple changing problems. For example, we as scientists continuously revise our teams and the way we integrate information, depending on the topics we study. As citizens, we participate in diverse collectives that use different strategies to address challenges ranging from economic development to climate change. This ability for collective adaptation contributed to our species’ spectacular success, b",{"id":30,"funder":7,"programme":8,"title":31,"piName":10,"institution":32,"country":33,"year":13,"amount":34,"abstract":35},"cordis-european-research-council-award-101142115","Reading Minds and Machines","WEIZMANN INSTITUTE OF SCIENCE","IL","€2,499,333","Can we decode the training data of a Deep Neural Network (DNN) directly from its parameters?Training data of DNNs are assumed safe. Recent findings by us and by others indicate that this is not the case, with severe implications on Data-Privacy. Yet, such findings shed light on why DNNs perform so well.On a different front: Can we decode what a person saw\u002Fheard\u002Fthinks directly from their brain activity?This may have huge benefits: communicate with “locked-in” patients, explore dreams, man-machin",{"id":37,"funder":7,"programme":8,"title":38,"piName":10,"institution":39,"country":40,"year":13,"amount":41,"abstract":42},"cordis-european-research-council-award-101142870","City buzz: Quantity, quality, and variety implications of the urban environment","FUNDACION CENTRO DE ESTUDIOS MONETARIOS Y FINANCIEROS","ES","€2,491,628","This research project aims to understand the changing landscape of cities. These are cities where face-to-face interactions happen less around office water coolers and more on the streets; where individuals not only produce differently by location but also have heterogeneous consumption; and where, beyond the adoption of working from home, the transformation of work involves a reorganisation of firms' establishments and hierarchies across locations.To capture face-to-face interactions accurately",{"id":44,"funder":7,"programme":8,"title":45,"piName":10,"institution":46,"country":47,"year":13,"amount":48,"abstract":49},"cordis-european-research-council-award-101141305","Assumption-Lean (Causal) Modelling and Estimation: A Paradigm Shift from Traditional Statistical Modelling","UNIVERSITEIT GENT","BE","€2,445,063","I propose a cutting-edge and transformative paradigm for statistical modelling that is crucial to enhance the quality of data analyses. Leveraging my expertise in causal inference and semiparametric statistics, I will establish the fundamental principles of a comprehensive estimation theory, which maps model parameters onto generic, interpretable, model-free estimands (e.g., association or effect measures) with favourable efficiency bound, and harnesses the power of debiased (statistical\u002Fmachine",{"id":51,"funder":7,"programme":8,"title":52,"piName":10,"institution":32,"country":33,"year":13,"amount":53,"abstract":54},"cordis-european-research-council-award-101140394","Computational design of synthetic antibody repertoires for accelerated therapeutic discovery","€2,741,000","Synthetic human antibody repertoires are an important source of therapeutics; however, antibodies often exhibit undesirable developability liabilities, such as low stability, solubility, and polyreactivity, that limit their potential as drug candidates. CADABRE will design next-generation repertoires comprising billions of diverse human antibodies that exhibit excellent developability properties, with the following aims:1. Repertoire design: We will use our newly developed combinatorial Rosetta ",{"id":56,"funder":7,"programme":8,"title":57,"piName":10,"institution":58,"country":59,"year":13,"amount":60,"abstract":61},"cordis-european-research-council-award-101141770","Pliocene Hominin Dispersal to southern Africa: Choice or Chance?","SENCKENBERG GESELLSCHAFT FUR NATURFORSCHUNG","DE","€2,499,248","Modern humans are unique in their ability to adapt to, and to thrive in, different environments. This trait facilitated their dispersal out-of-Africa to higher latitudes, i.e. to temperate and seasonal habitats, during the Pleistocene. However, there are Plio-Pleistocene hominins at higher latitudes in South Africa (SA) from ~3.7Ma onwards. Did human behavioural\u002Fphysiological flexibility evolve early in our evolutionary history? Alternatively, did Pliocene hominins occupy such temperate zones du",{"id":63,"funder":7,"programme":8,"title":64,"piName":10,"institution":65,"country":66,"year":13,"amount":67,"abstract":68},"cordis-european-research-council-award-101141351","Computational model predictive and adaptive control tools","SCUOLA IMT (ISTITUZIONI, MERCATI, TECNOLOGIE) ALTI STUDI DI LUCCA","IT","€2,499,375","Model predictive control (MPC) is applied with success in industry for automating constrained multivariable dynamical systems in an optimized way. However, some crucial aspects of MPC design largely remain to be addressed to unleash the full potential of MPC in applications: the efforts required to collect experimental data, identify the prediction model, and calibrate the controller, must be reduced considerably; the controller must self-adapt seamlessly to cope with unforeseen changes and not ",{"id":70,"funder":7,"programme":8,"title":71,"piName":10,"institution":72,"country":33,"year":13,"amount":73,"abstract":74},"cordis-european-research-council-award-101141253","Packing in Discrete Domains - Geometry and Analysis","THE HEBREW UNIVERSITY OF JERUSALEM","€2,194,125","The packing problem associated with a family of sets F seeks a large subfamily of pairwise disjoint members of F. When F comprises the unit balls in d-space, this is the sphere packing problem, which for d = 3 was solved by Hales-Ferguson (Keplers conjecture). The cases d = 8, 24 have won Viazovska her Fields Medal. Much of discrete mathematics deals with dense packing problems. The asymptotic rate vs. distance problem, may be the most fundamental open problem about error correcting codes. It se",{"id":76,"funder":7,"programme":8,"title":77,"piName":10,"institution":46,"country":47,"year":13,"amount":78,"abstract":79},"cordis-european-research-council-award-101140903","New Polities. Political thought in the first millennium","€2,499,750","In the history of political thought, Late Antiquity is usually considered the period when the city-state gave way to monarchy and the Bible and Qur’an took the place of Plato. With a focus on kingship and religion, late antique political thinking – so the story goes – represents the antithesis of modern republicanism and secularism. For far too long, this teleological perspective has directed scholars toward a narrow range of topics and inhibited the recognition of different narratives and integ",{"id":81,"funder":7,"programme":8,"title":82,"piName":10,"institution":83,"country":84,"year":13,"amount":85,"abstract":86},"cordis-european-research-council-award-101142242","Manuscript Culture in the Age of Print","UNIVERSITE DE TOURS","FR","€2,499,369","The PRIMA project will redefine our understanding of how culture was produced and disseminated in Early Modern Europe (1575-1800). PRIMA will uncover the importance and the scale of manuscript production and publication for literature, science, music, and other areas, for a period when print is believed to be the dominant (if not the only) technology for publication. By investigating the indissoluble connection between text and carrier, PRIMA will explore how manuscripts have shaped society for ",{"id":88,"funder":7,"programme":8,"title":89,"piName":10,"institution":90,"country":40,"year":13,"amount":91,"abstract":92},"cordis-european-research-council-award-101142892","Biocultural roots of diversity and inequality in Mexico: 500 years of mestizo stories","UNIVERSIDAD DE BURGOS","€2,495,911","Transatlantic contact during the 1400s ignited a series of socio-economic, political, demographic and biocultural changes that irreversibly transformed the course of history in the Americas with repercussions across the world. But one of the most influential encounters occurred in 1519 between the Mexica empire and the Spanish and African troops of Hernn Cortes in the basin of todays Mexico. The transformational consequences were unparalleled at the time, but equally consequential is the way tha",{"id":94,"funder":7,"programme":8,"title":95,"piName":10,"institution":96,"country":97,"year":13,"amount":98,"abstract":99},"cordis-european-research-council-award-101141800","Reading the mind’s eye: AI-inspired personalised brain models of mental imagery","UNIVERSITEIT MAASTRICHT","NL","€2,498,288","How do we create mental images? Despite extensive research, we still miss an overarching mechanistic understanding of mental imagery: How do the various brain regions involved in mental imagery contribute to the unified percept in our mind's eye? Why do we experience imagery so differently ranging from no to extremely vivid mental images? In this project, we propose a novel perspective on mental imagery, viewing it as a personalised computational process that takes into account individual brain ",{"id":101,"funder":7,"programme":8,"title":102,"piName":10,"institution":103,"country":97,"year":13,"amount":104,"abstract":105},"cordis-european-research-council-award-101141804","PIWI-interacting RNAs at the interface of virus-host conflicts in Aedes aegypti mosquitoes","STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM","€2,500,000","Background: The mosquito Aedes aegypti transmits viruses with pandemic potential but is also host to a large repertoire of mosquito-specific viruses and endogenous retroviruses. These viruses may invade the ovaries and eventually the oocyte to be transmitted from mother to offspring and to expand in the population. This transmission route exposes them to the specific host defense mechanisms of the ovary, which they must overcome to ensure onward transmission. This intriguing virus–host conflict ",{"id":107,"funder":7,"programme":8,"title":108,"piName":10,"institution":72,"country":33,"year":13,"amount":104,"abstract":109},"cordis-european-research-council-award-101141400","THE ROMAN TURN AMONG JEWS, GREEK PAGANS, AND CHRISTIANS","ROMANA aims to unveil the ubiquitous presence of Rome in Jewish, Greek-Pagan and Christian texts and to expose the strategies of cultural interaction between imperialist forces and a range of minority groups. It will explore how intellectual discourses that have defined the West, namely those of Greek elites, Christian groups, as well as Hellenistic and rabbinic Judaism, were constructed through a series of contested, hidden, and disavowed interactions with the dominant force of empire. The proj",{"id":111,"funder":7,"programme":8,"title":112,"piName":10,"institution":113,"country":59,"year":13,"amount":114,"abstract":115},"cordis-european-research-council-award-101142067","Platelet-derived Integrin- and Tetraspanin-enriched Tethers as key effectors in thrombo-Inflammation","UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT","€2,499,250","Platelets are mediators of haemostasis and thrombosis, but also increasingly recognized as versatile effector cells of innate immunity. The concept of thrombo-inflammation recognizes that thrombotic and inflammatory pathomechanisms are closely intertwined. Platelets thereby act as central orchestrators of immune cell trafficking, vascular barrier function and organ integrity and contribute to organ injury in severe disorders with limited treatment options (e.g. stroke, sepsis, ARDS). The underly",{"id":117,"funder":7,"programme":8,"title":118,"piName":10,"institution":119,"country":66,"year":13,"amount":120,"abstract":121},"cordis-european-research-council-award-101142666","Plurilateral integration agreements and noneconomic objectives","EUROPEAN UNIVERSITY INSTITUTE","€2,499,865","This project revisits the centrality of trade agreements as a mechaniThis project revisits the centrality of trade agreements as a mechanism for  international cooperation. Intervention in international trade and investment increasingly is motivated by noneconomic objectives – fighting climate change, national security, safeguarding societal values – complementing economic competitiveness objectives. Multilateral agreements to reduce associated competitiveness spillovers are constrained by geopo",{"id":123,"funder":7,"programme":8,"title":124,"piName":10,"institution":125,"country":66,"year":13,"amount":126,"abstract":127},"cordis-european-research-council-award-101141533","Surfing radio Waves to detect  liquId water in the solar systeM","UNIVERSITA DEGLI STUDI ROMA TRE","€3,176,790","In the near future a number of space missions will aim to study the icy Galilean satellites of Jupiter to detect subglacial liquid water, using radar sounders. To properly interpret the radar data, it is necessary to understand the dielectric properties of the icy shells of these bodies, as they control radar signal penetration and anomaly (i.e., water) detection. The current knowledge of these properties for the types of water ices believed to be present is limited, which would potentially prod",{"id":129,"funder":7,"programme":8,"title":130,"piName":10,"institution":131,"country":132,"year":13,"amount":133,"abstract":134},"cordis-european-research-council-award-101142356","Far-infrared semiconductor electronics","CHALMERS TEKNISKA HOGSKOLA AB","SE","€2,499,828","The project will establish frontline semiconductor terahertz electronics for far-infrared space instruments by exploring and combining InP-based semiconductors with thin silicon membrane technology. The goal is to obtain high receiver sensitivity and stability for much less power consumption beyond what is currently considered state-of-the-art in the 2-5 THz frequency range.Terahertz measurements of the atmosphere are made routinely to monitor and reveal physical and chemical processes related t",{"id":136,"funder":7,"programme":8,"title":137,"piName":10,"institution":138,"country":59,"year":13,"amount":139,"abstract":140},"cordis-european-research-council-award-101141332","High-Performance Computational Photochemistry and Spectroscopy","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","€2,488,013","The future of modern sustainable technologies lies in the exploitation of solar energy and in harnessing the sun’s practically infinite energy. For fundamental as well as target-oriented research in this direction, computer simulations of the ongoing photochemical processes and electronic spectroscopy of the underlying molecular materials are indispensable. While for smaller molecules, computational photochemistry can nowadays provide highly accurate results and reliable predictions, the limit i",{"id":142,"funder":7,"programme":8,"title":143,"piName":10,"institution":144,"country":40,"year":13,"amount":104,"abstract":145},"cordis-european-research-council-award-101142005","The transcriptional regulation of cardiomyocyte polyploidization and its relevance in cardiac regeneration","CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)","The mammalian heart is a non-regenerative organ due to the extremely limited ability of fully differentiated cardiomyocytes (CMs) to proliferate. While neonatal hearts still contain mostly diploid CMs and regenerate efficiently, physiological postnatal CM polyploidization\u002Fhypertrophy ensures the contractile capacity of the adult myocardium but represents a roadblock to cardiac regeneration. Due to this limitation, diseases that provoke CM loss, like acute ischemia, frequently lead to heart failu",{"id":147,"funder":7,"programme":8,"title":148,"piName":10,"institution":46,"country":47,"year":13,"amount":149,"abstract":150},"cordis-european-research-council-award-101142229","VIrtual GuardIan AngeLs for the post-truth Information Age","€2,490,000","This project is motivated by the hypothesis that we are approaching a post-truth society, where it becomes practically impossible for anyone to distinguish fact from fiction in all but the most trivial questions. A main cause of this evolution is people’s innate dependence on cognitive heuristics to process information, which may lead to biases and poor decision making. These biases risk being amplified in a networked society, where people depend on others to form their opinions and judgments an",{"id":152,"funder":7,"programme":8,"title":153,"piName":10,"institution":154,"country":26,"year":13,"amount":155,"abstract":156},"cordis-european-research-council-award-101140687","The Geopoliticization of Trade Policy","PARIS-LODRON-UNIVERSITAT SALZBURG","€2,485,639","Currently, we witness the “geopoliticization” of trade, namely the linking of national security concerns to trade policy. While this geopoliticization is related to the U.S.-China trade war and the Russian invasion of Ukraine, it has become a broad phenomenon affecting most countries worldwide. Much existing research sees governments in the driver’s seat of this process. By contrast, I explain the domestic politics behind the geopoliticization of trade policy focusing on the interaction between ",{"id":158,"funder":7,"programme":8,"title":159,"piName":10,"institution":160,"country":84,"year":13,"amount":161,"abstract":162},"cordis-european-research-council-award-101142672","Virtual planets to unravel how mantle convection shapes geosphere, climate and life co-evolution","UNIVERSITE COTE D'AZUR","€2,144,646","The Earth's geosphere, hydrosphere, atmosphere, and biosphere have co-evolved together as a single planetary system for billions of years, resulting in a complex web of systemic interactions that have shaped the geological record and biodiversity. However, the complexity of these interactions and the incomplete geological record make it impossible to replay the tape and fully explore the profound mechanisms at play. Here I propose to uncover how mantle convection shapes with the evolution of bot",{"id":164,"funder":7,"programme":8,"title":165,"piName":10,"institution":166,"country":26,"year":13,"amount":167,"abstract":168},"cordis-european-research-council-award-101142075","The Inner Galapagos –  Molecular Ecology of the Retroviral-piRNA Arms Race","INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH","€2,498,943","The ongoing arms race between transposable elements and their host organisms is a central driver of genetic innovation and biological diversity. Yet, despite this crucial role, the underlying principles that govern transposon-host interactions remain poorly understood. The ERVolution project aims to gain critical insights into the evolutionary dynamics and rules of the ancient transposon-host conflict. The project focuses on the Drosophila ovary ecosystem and the diversification of insect endoge",{"id":170,"funder":7,"programme":8,"title":171,"piName":10,"institution":172,"country":173,"year":13,"amount":174,"abstract":175},"cordis-european-research-council-award-101141916","Artificial User","AALTO KORKEAKOULUSAATIO SR","FI","€2,499,208","PROBLEM: Despite decades of research on human-computer interaction (HCI), the problem of how to predict human performance with a given user interface (UI) is unsolved. Existing computational models are limited in scope or require large datasets or expert input. Instead, empirical methods are used that are costly and error-prone. OBJECTIVE: This project establishes the foundations of simulation intelligence in HCI through computational rationality. Given a design and a task environment, a simulat",{"id":177,"funder":7,"programme":8,"title":178,"piName":10,"institution":32,"country":33,"year":13,"amount":179,"abstract":180},"cordis-european-research-council-award-101142391","Modulation of valence-based learning and behavior:  a closed-loop approach in the primate amygdala","€2,250,000","The primate amygdala is a neural hub that processes computations for learning and memory, specifically when learning involves emotional, motivational, and reinforcement-based signals. This requires it to remain highly adaptive for changes in valence of environments and stimuli. Failures of such computations can lead to maladaptive behaviors and even psychopathologies such as PTSD and Anxiety. However, the core principles of amygdala function continue to elude the field. Recent studies suggest va",{"id":182,"funder":7,"programme":8,"title":183,"piName":10,"institution":184,"country":59,"year":13,"amount":185,"abstract":186},"cordis-european-research-council-award-101142587","Cognitive deficits resulting from selective vulnerability of septal inhibitory neurons: mitochondrial dysfunction as a driver?","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","€2,000,000","Septal GABAergic projection neurons are considered “pacemaker” cells as they enable the temporal organization of neuronal spike firing in hippocampal and entorhinal networks that support spatial- and object-coding. Accordingly, medial septum inactivation is associated with cognitive impairments, but the specific role of the septal-entorhinal GABAergic projections therein has remained unexplored. This is a pressing question, as we have evidence that septal GABAergic projections exhibit enhanced v",{"id":188,"funder":7,"programme":8,"title":189,"piName":10,"institution":190,"country":66,"year":13,"amount":191,"abstract":192},"cordis-european-research-council-award-101142844","Traits and Games: How Personal Cognitive and Psychological Features Affect Strategic Behavior","UNIVERSITA COMMERCIALE LUIGI BOCCONI","€1,874,575","I will analyse how agents’ traits affect behaviour and strategic reasoning in decision problems and games. Traits encompass stable cognitive and psychological features of agents, such as tastes, skills, cognitive abilities, attitudes toward uncertainty and misspecification, concerns for others, and propensities to be affected by emotions. To build an adequate formal framework, I will try to comply with a separation principle: the description of the rules of interaction should be separate and ind",{"id":194,"funder":7,"programme":8,"title":195,"piName":10,"institution":46,"country":47,"year":13,"amount":10,"abstract":196},"cordis-european-research-council-award-101141743","Global Migration Justice: Beyond conflicting approaches to migration in international human rights law","MIGJUST addresses the unacknowledged, fundamental conflict between the European Court of Human Rights, which in its migration case law adopts a sovereignty approach normalising sedentarism, and the Inter-American and African human rights Commission and Court which adopt a human rights approach normalising mobility. This fragmentation of international law also plays out in UN human rights Committees. This fragmentation is not acknowledged in academic work, in which the European approach is assume",{"id":198,"funder":7,"programme":8,"title":199,"piName":10,"institution":200,"country":84,"year":13,"amount":201,"abstract":202},"cordis-european-research-council-award-101141693","Noncommutative ergodic theory of higher rank lattices","ECOLE NORMALE SUPERIEURE","€2,140,250","Noncommutative ergodic theory of higher rank lattices is a current topic that has seen several exciting developments in the last five years. Among these recent advancements, in joint work with Rmi Boutonnet (2019), we proved a noncommutative analogue of Nevo-Zimmer's structure theorem for actions of higher rank lattices on von Neumann algebras. First of all, we derived several novel applications to ergodic theory, topological dynamics, unitary representation theory and operator algebras associat",{"id":204,"funder":7,"programme":8,"title":205,"piName":10,"institution":206,"country":33,"year":13,"amount":78,"abstract":207},"cordis-european-research-council-award-101141436","Mapping the Connectome Dynamics of Trauma Psychopathology","TEL AVIV UNIVERSITY","Exposure to a traumatic event can induce psycho-physiological reactions and symptoms that in most people recede over time. A minority of trauma-exposed individuals develop posttraumatic stress disorder (PTSD), characterized by severe functional and emotional impairment. The global burden of PTSD is estimated in the hundreds of billions of Euros and millions of years lived with disability. Individual differences in neurobiological vulnerability to traumatic stress have been studied extensively, y",{"id":209,"funder":7,"programme":8,"title":210,"piName":10,"institution":211,"country":212,"year":13,"amount":213,"abstract":214},"cordis-european-research-council-award-101141445","Electricity generated from heat with nonlinear pyroelectric materials","LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY","LU","€2,359,064","Electric energy stands for 20% of the total energy consumed in the world, and this share is expected to reach 40% by 2050 as an outcome of the need to decrease our dependence on non-renewable energies. Beyond sunlight and wind, heat is another formidable and poorly exploited source of electrical energy. Indeed, currently 72 % of the energy produced ends up in waste heat - and it has been predicted that up to 13 000 TWh could be recovered each year, which stands for Europe’s yearly total energy n",{"id":216,"funder":7,"programme":8,"title":217,"piName":10,"institution":218,"country":59,"year":13,"amount":104,"abstract":219},"cordis-european-research-council-award-101142335","Neuronal circuits for sensory-body state integration","MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)","Thermal homeostasis is essential to survival. But how our brain processes thermosensory information and triggers behaviors that help maintain our physiological, body state remains a mystery. The neural circuits responsible for perception of sensory stimulation and those for regulation of body state have been studied independently, yet body state has a profound impact on sensory perception. What is more, animals constantly adapt their behavior to maintain homeostasis with moment-by-moment sensing",{"id":221,"funder":7,"programme":8,"title":222,"piName":10,"institution":184,"country":59,"year":13,"amount":223,"abstract":224},"cordis-european-research-council-award-101141901","Characterizing and harnessing tumor-reactive T cells in the brain","€2,499,861","Personalized tumor immunotherapy - vaccines and T cell therapies - requires the selection of few immunogenic epitopes recognized by tumor-reactive T cell receptors (TCRs) from thousands of potential tumor antigens in each tumor. This selection is a huge challenge, particularly in brain tumors, where access to tumor tissue is limited and tumor-infiltrating T cells (TILs) are sparse. CENTRIC-BRAIN will reverse this epitope-centric approach by directly harnessing tumor-reactive orphan TCRs from TIL",{"id":226,"funder":7,"programme":8,"title":227,"piName":10,"institution":228,"country":229,"year":13,"amount":230,"abstract":231},"cordis-european-research-council-award-101122990","Goal-Oriented Networking for Space","MIDDLE EAST TECHNICAL UNIVERSITY","TR","€2,433,063","The accelerated pace of space exploration, interplanetary and non-terrestrial connectivity calls for scalable and efficient communication network architectures that can achieve end-to-end effectiveness for increasing numbers of bursty flows, occurring in applications such as remote inference, monitoring and automation.  This is made challenging by the variable delays and disruptions that sometimes preclude real-time communication and end-to-end acknowledgements. We propose to tackle this fundame",{"id":233,"funder":7,"programme":8,"title":234,"piName":10,"institution":235,"country":59,"year":13,"amount":236,"abstract":237},"cordis-european-research-council-award-101141293","“(De)Colonizing Sharia?” Tracing Transformation, Change and Continuity in Islamic Law in the Middle East and North Africa (MENA) in the 19th and 20th Centuries","UNIVERSITAT ERFURT","€2,554,891","European colonialisms encounter with Islamic law or Sharia, the main pillar of the pre-colonial legal systems in the Middle East and North Africa (MENA), has had a tremendous impact until today. The implementation of modern European-style legal systems has led, as some scholars claim, to the abolishment of Sharia. Others consider the legal changes through which Muslim societies have transited as a sign of Sharias flexibility rather than its demise. The principal question this project addresses i",{"id":239,"funder":7,"programme":8,"title":240,"piName":10,"institution":241,"country":84,"year":13,"amount":242,"abstract":243},"cordis-european-research-council-award-101141171","Growing Up Across Borders: Experiences of Young People in Forced Migration","UNIVERSITE PARIS 8 VINCENNES SAINT-DENIS","€2,213,225","Since 2015, over 5 million people have arrived, or tried to arrive in the European Union seeking refuge. Other refugee receiving countries are faced with similar situations. Many of these refugees are young people. But whilst much has been written about the experiences of adult refugees and to a lesser extent about unaccompanied minors, there is very little research on the experiences of young refugees who are not (or are not recognized as) “unaccompanied”, and specifically about how these exper",{"id":245,"funder":7,"programme":8,"title":246,"piName":10,"institution":247,"country":59,"year":13,"amount":248,"abstract":249},"cordis-european-research-council-award-101141989","Towards a spatial coexistence theory for species rich communities","HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ","€2,497,799","Ecologists have tried for long to explain coexistence of many competing species in communities such as tropical forests, but this key question of ecological theory remains largely unresolved. We argue that this failure originates as a scaling problem. Although plants compete mostly with their closest neighbours, the phenomenological models of most approaches addressing this question do not consider spatial mechanisms of how the dynamics and patterns at the “macroscopic” community scale emerge fr",{"id":251,"funder":7,"programme":8,"title":252,"piName":10,"institution":253,"country":59,"year":13,"amount":254,"abstract":255},"cordis-european-research-council-award-101142366","Unpacking Paradigmatic Gaps","GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS","€2,492,200","Universal paradigmatic gaps are gaps in linguistic paradigms that appear across languages and across users of a given language. As of yet, only very few gaps of this kind have been discussed in the literature. The one gap that has received substantial discussion concerns the universal absence of a lexicalized negated form for the quantifiers all, every or always: There appears to be no language in the world that exhibits a single word (or lexical item) that means ‘not all’, ‘not every’ or ‘not a",{"id":257,"funder":7,"programme":8,"title":258,"piName":10,"institution":259,"country":260,"year":13,"amount":261,"abstract":262},"cordis-european-research-council-award-101141468","Knots and Surfaces in four-manifolds","HUN-REN RENYI ALFRED MATEMATIKAI KUTATOINTEZET","HU","€1,991,875","Four-dimensional smooth manifolds show very different behaviour than manifolds in any other dimension. In fact, in other dimensions we have a somewhat clear picture of the classification, while dimension four is still elusive. The project aims to further our knowledge in this question in several ways. The genus function, and its enhanced version taking knots and their slice surfaces into account, plays a crucial role in understanding different smooth structures on four-manifolds. Techniques for ",{"id":264,"funder":7,"programme":8,"title":265,"piName":10,"institution":206,"country":33,"year":13,"amount":266,"abstract":267},"cordis-european-research-council-award-101142020","Exact and Approximate Computation of Tensors and Polynomials","€2,335,000","This research proposal will address fundamental problems concerning the complexity of computingand manipulating polynomials. For example, consider the following questions:1. What is the complexity of computing the total weight of perfect matchings of a weighted graph?2. Is there an efficient deterministic parallel algorithm that determines whether a graph has a perfect matching?3. Is approximation much easier than exact computation?4. How many EPR pairs can we distill from a given quantum state?",{"id":269,"funder":7,"programme":8,"title":270,"piName":10,"institution":72,"country":33,"year":13,"amount":271,"abstract":272},"cordis-european-research-council-award-101142781","The Langlands Correspondence","€1,976,875","R. Langlands conjectured the existence of a correspondence between automorphic spectrums of Hecke algebras and representations of Galois groups of global fields. The existence of such correspondence is one of the main conjectures in mathematics. Even if not known in full generality it leads to proofs of Ferma and Sato-Tate conjectures. This project is on three aspects of the Langlands correspondence. The first part of this project is a description of the spectrum of Hecke algebras on the space g",{"id":274,"funder":7,"programme":8,"title":275,"piName":10,"institution":276,"country":59,"year":13,"amount":114,"abstract":277},"cordis-european-research-council-award-101141738","Saving the Kashmirian Sanskrit Heritage","PHILIPPS UNIVERSITAET MARBURG","The importance of Kashmirian Sanskrit Literature was realised by scholars only in the late 19thcentury, when the literary canon and historiography of Sanskrit Literature in the Indiansubcontinent had already taken shape. Texts and whole genres that were unique to Kashmir, aspolitical history, were not properly recognised and led to a distorted view of South Asianliterature. Much has changed, especially in the last decades, but the latest exodus and dissipationof the Kashmirian Hindu community is",{"id":279,"funder":7,"programme":8,"title":280,"piName":10,"institution":281,"country":59,"year":13,"amount":282,"abstract":283},"cordis-european-research-council-award-101141285","A mechanism-based approach to  the prevention of chronic pain and its comorbid mental disorders","ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT","€2,424,481","Chronic pain is a major health problem typically associated with mental disorders such as depression or anxiety and is still difficult to treat despite enormous efforts in the biomedical community. This project proposes a radical shift from the symptomatic focus on chronic pain and predefined diagnostic categories to a mechanistic analysis and treatment of psychobiological factors that shape the transition to chronic pain and its associated mental diorders in a transdiagnostic approach. The prop",{"id":285,"funder":7,"programme":8,"title":286,"piName":10,"institution":287,"country":59,"year":13,"amount":104,"abstract":288},"cordis-european-research-council-award-101141331","Curvilinear multiferroics","HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF EV","Disruptive development of brain-inspired computing, machine learning and deep neural networks for electronic assistants in smartphones, autonomous driving systems or chatGPT require new logic and storage concepts, which are beyond conventional von Neumann computer architectures. Materials known as multiferroics are identified as key enablers of these technologies. In contrast to ferromagnets, where the magnetic state is controlled by magnetic fields (energy inefficient due to flowing currents), ",{"id":290,"funder":7,"programme":8,"title":291,"piName":10,"institution":292,"country":26,"year":13,"amount":293,"abstract":294},"cordis-european-research-council-award-101142427","Agents of Logistics and Infrastructure in Eighteenth Century Alpine Transit Traffic","UNIVERSITAT WIEN","€2,499,921","ALPINNKONNECT centres on operating trans-European commercial traffic as engine and manifestation of eighteenth-century prosperity. The project focuses on the interplay of agents, material prerequisites and natural impacts along main Alpine transit routes, applying an approach of socio-material-natural interconnectedness. It advances the hypothesis that transportation required a broad participation to cope with the enormous efforts and provided an important source of income. Hence, seen through t",{"id":296,"funder":7,"programme":8,"title":297,"piName":10,"institution":298,"country":33,"year":13,"amount":104,"abstract":299},"cordis-european-research-council-award-101141917","Dendrite assemblies as the core cortical computation module for continual motor learning","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","The cortex has the amazing capacity to continuously learn through experience while retaining past memories. But how does the cortical network implement this continual learning while avoiding interference and catastrophic overwriting of prior events? While cell assemblies with simple point neurons are thought to serve as the basic learning and storage units, this model poses major challenges in dynamic environments and lacks experimental support. Relying on strong preliminary results, I here prop",{"id":301,"funder":7,"programme":8,"title":302,"piName":10,"institution":218,"country":59,"year":13,"amount":104,"abstract":303},"cordis-european-research-council-award-101142488","Molecules for Nociceptor Force Transduction","Pain results from activation of the nociceptive sensory system, which is built upon the primary afferent nociceptor a type of sensory neuron specialized to detect, code and relay information about potentially or actually damaging stimuli. Humans lacking properly functioning nociceptors never experience pain and have reduced life expectancy and suffer severe disability. Nociceptors detect sustained force into ranges that are potentially damaging and sustained nociceptor activation will always lea",{"id":305,"funder":7,"programme":8,"title":306,"piName":10,"institution":307,"country":47,"year":13,"amount":104,"abstract":308},"cordis-european-research-council-award-101142702","Deep Probabilistic Logics","KATHOLIEKE UNIVERSITEIT LEUVEN","Neurosymbolic AI (NeSy) is the 3rd wave in AI. It wants to answer the key open question in AI as how to combine learning (2nd wave) and reasoning (1st wave) by integrating logic based AI with deep learning. However, there is only little understanding of the underlying principles and there exist no widely used machine learning tools that support NeSy. This makes the development of learning and reasoning systems extremely hard. What is urgently needed is a paradigm shift in NeSy that focuses on fo",{"id":310,"funder":7,"programme":8,"title":311,"piName":10,"institution":307,"country":47,"year":13,"amount":78,"abstract":312},"cordis-european-research-council-award-101133276","Concomitant Reversal of Adrenal Insufficiency and Muscle Weakness to Enhance Recovery from Prolonged Critical Illness","Sepsis, complicated surgery or extensive trauma cause hyperinflammation-induced critical illness which requires vital organ support in an intensive care unit (ICU) in order to avoid imminent death. Although modern intensive care has reduced mortality, a large number of survivors continue to require such supportive care in the ICU sometimes for weeks or months. Once in this prolonged phase, typical ICU-acquired morbidities such as lingering organ failure, muscle wasting and weakness and vasopress",{"id":314,"funder":7,"programme":8,"title":315,"piName":10,"institution":307,"country":47,"year":13,"amount":316,"abstract":317},"cordis-european-research-council-award-101141362","Open Superior Efficient Solar Atmosphere Model Extension","€2,498,230","The goal is to develop a time evolving model for the entire solar atmosphere, including the chromosphere and transition region, based on a multi-fluid description. At present, models are steady, rely on a single-fluid description and include only the corona due to computational challenges. We plan to use time-evolving ion-neutral and ion-neutral-electron models. The multi-fluid approach will enable us to describe the intricate physics in the partially ionized chromosphere and quantize the transf",{"id":319,"funder":7,"programme":8,"title":320,"piName":10,"institution":321,"country":59,"year":13,"amount":322,"abstract":323},"cordis-european-research-council-award-101141626","Automated Model Discovery for Soft Matter Systems","FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG","€2,775,408","Soft materials play an integral part in many aspects of modern life including autonomy, sustainability, and human health, and their accurate modeling is critical to understand their unique properties and functions. However, the criteria for model selection remain elusive and successful modeling is limited to a few well-trained specialists in the field. My goal is to democratize constitutive modeling through automated model discovery and make it accessible to a more inclusive and diverse communit",{"id":325,"funder":7,"programme":8,"title":326,"piName":10,"institution":292,"country":26,"year":13,"amount":327,"abstract":328},"cordis-european-research-council-award-101142107","Unravelling the evolutionary origin, architecture, development and regulation of neuromuscular systems","€2,499,076","Muscles and neurons are a major hallmark of animals and given their impact on the organisms motility, the emergence of an interacting neuro-muscular system has tremendously shaped the evolution of animal body plans and behavioral repertoire. Neurons and muscle cells closely interact and likely have co-evolved. Yet, the evolutionary origin of different neuronal and muscular cell types remains elusive, mainly due to a lack of thorough studies in basal metazoans. In this project, I aim to unravel t",{"id":330,"funder":7,"programme":8,"title":331,"piName":10,"institution":292,"country":26,"year":13,"amount":332,"abstract":333},"cordis-european-research-council-award-101142567","From the paradox of individuality to the logic of representation. Individuals and descriptions in Byzantine thought (4th-12th centuries)","€2,400,131","An individual is a unique, non-repeatable entity which is discernable from all other members of the same species. A theory of individuality is an explanation of the mode of being of the individuals.In the Aristotelian philosophical tradition, which is one of the essential components of Byzantine thought, individuals have a particular status; as primary substances they are both: the ontological foundation of reality and the first object of perception - I see Petros, not humanity - ; but at the sa",{"id":335,"funder":7,"programme":8,"title":336,"piName":10,"institution":292,"country":26,"year":13,"amount":337,"abstract":338},"cordis-european-research-council-award-101141581","NEutRally buoyant ParticlEs In the DEep Sea: turnover, origin and global impact on the marine carbon cycle","€2,841,791","Export of organic matter produced in the sunlit surface waters into the oceans interior removes about one third of the anthropogenically produced carbon dioxide. The amount of organic matter sinking into the deep ocean, however, is not sufficient to support the carbon demand of the heterotrophic food web in the oceans interior as revealed by several studies. Consequently, the oceanic carbon budget cannot be closed. Recently, we identified a hitherto unrecognised non-sinking, non-living particula",{"id":340,"funder":7,"programme":8,"title":341,"piName":10,"institution":342,"country":84,"year":13,"amount":343,"abstract":344},"cordis-european-research-council-award-101141508","Universality Phenomena in Geometry and Dynamics of Moduli spaces","UNIVERSITE PARIS CITE","€1,609,028","Geometry and dynamics in the moduli spaces proved to be extremely efficient in the study of surface foliations, billiards in polygons and in mathematical models of statistical and solid state physics like Ehrenfest billiards or Novikov's problem on electron transport. Ideas of study of surface dynamics through geometry of moduli spaces originate in works of Thurston, Masur and Veech. The area is flourishing ever since. Contributions of Avila, Eskin, McMullen, Mirzakhani, Kontsevich, Okounkov, Yo",{"id":346,"funder":7,"programme":8,"title":347,"piName":10,"institution":348,"country":349,"year":13,"amount":350,"abstract":351},"cordis-european-research-council-award-101141906","Scholars, Animals, Images, Geographies, and the Arts: De-exoticizing Eastern Europe in the Early Modern Period","UNIWERSYTET WARSZAWSKI","PL","€2,497,775","Building on Claude Lévi-Strauss’s oft-cited claim that “animals are good to think with,” SAIGA sets out to forge a zoological trail in the understanding of Eastern Europe between the sixteenth and late eighteenth centuries. Focusing on animal representations, the project will shed new light on the role of images in the production and transfer of knowledge.The project will highlight the region’s underrated contributions to the development of natural history by examining the overlooked Eastern Eur",{"id":353,"funder":7,"programme":8,"title":354,"piName":10,"institution":355,"country":84,"year":13,"amount":356,"abstract":357},"cordis-european-research-council-award-101141644","Multiscale mechanobiological synergies  in vascular homeostasis, ageing and rejuvenation","INSTITUT MINES-TELECOM","€2,795,438","Whilst 30% of EU citizens will be over 65 and 10% over 80 by 2050, the healthspan accounts for only 80% of the total life expectancy according to Eurostat, due to the high prevalence of disabling diseases related to the age-induced arterial stiffening. The current paradigm in medicine is to palliate these diseases with sophisticated devices. In JuvenTwin, I propose a complete shift of paradigm by combatting the mechanobiological effects of vascular ageing. Vascular rejuvenation faces many challe",{"id":359,"funder":7,"programme":8,"title":360,"piName":10,"institution":361,"country":59,"year":13,"amount":362,"abstract":363},"cordis-european-research-council-award-101141501","Mechanisms of Camouflage in Cuttlefish","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€2,499,758","Cephalopod camouflage (or crypsis) is one of the most fascinating behaviors in the animal kingdom. It is also very relevant for neuroscience, for many reasons. First, the ability of cephalopods to escape detection by vertebrate predators or invertebrate prey indicates that the perception of textures must follow similar principles in most species; if they did not, crypsis would not be successful. Because cephalopods and vertebrates diverged over 550 M years ago from a primitive common ancestor, t",{"id":365,"funder":7,"programme":8,"title":366,"piName":10,"institution":367,"country":368,"year":13,"amount":104,"abstract":369},"cordis-european-research-council-award-101142708","Lysine Acetylation: The Scope and Function in Gene Activation","KOBENHAVNS UNIVERSITET","DK","Transcription, the first and most crucial step in decoding the genome, is orchestrated by an extensive repertoire of transcription factors (TFs). These TFs transmit diverse signals to the nucleus, directing precise temporal and spatial gene activation programs. They employ a diverse array of transcription coactivators to impact transcription, including lysine acetyltransferases (KATs), an evolutionarily conserved group of coactivators found in all eukaryotes. Lysine acetylation serves as a hallm",{"id":371,"funder":7,"programme":8,"title":372,"piName":10,"institution":373,"country":97,"year":13,"amount":104,"abstract":374},"cordis-european-research-council-award-101141330","Deep Culture - Living with Difference in the Age of Deep Learning","UNIVERSITEIT VAN AMSTERDAM","In 2022, the world appeared transformed by a new consumer artificial intelligence (AI), which has dazzled observers with the ability to generate text, images or music. This transformation has been brought about not by general AI but by deep learning, a specific subset of machine learning that has come to dominate AI scientifically and commercially. This has given rise to an emergent ‘deep culture’, which is produced with universal data extraction and on an industrial scale. While these developme",{"id":376,"funder":7,"programme":8,"title":377,"piName":10,"institution":361,"country":59,"year":13,"amount":104,"abstract":378},"cordis-european-research-council-award-101140768","Plant mitochondrial genome engineering: technology development and application to study fundamental aspects of mitochondrial gene expression","PlaMitEng has the highly ambitious overall objective to make the mitochondrial genome of seed plants amenable to genetic engineering. The project consists of two complementary work packages (WPs). In WP1, TALEN-GDM, a technology for plant mitochondrial genome editing recently developed by us will be used to systematically study plant mitochondrial gene expression in vivo. The focus will be on translation initiation and translational regulation in mitochondria, the mechanisms of which are current",{"id":380,"funder":7,"programme":8,"title":381,"piName":10,"institution":361,"country":59,"year":13,"amount":104,"abstract":382},"cordis-european-research-council-award-101141942","High Resolution Laser Spectroscopy of Atomic Hydrogen and Deuterium","Discrepancies between theory and experiments have been fueling the development of physics. Today, Quantum Electrodynamics (QED) is the most accurate theory and served as a blueprint for all subsequent field theories. Physics beyond the Standard Model must exist as we know from observations of the cosmos. It is likely to be found where no one has looked before, i.e., at very large energies, high sensitivity, or high precision. To progress with the so-called precision frontier, high resolution spe",{"id":384,"funder":7,"programme":8,"title":385,"piName":10,"institution":361,"country":59,"year":13,"amount":149,"abstract":386},"cordis-european-research-council-award-101142809","TURBULENCE, PEBBLES AND PLANETESIMALS : THE ORIGIN OF MINOR BODIES IN THE SOLAR SYSTEM","The Minor Bodies of the Solar System, Asteroids, Trojans, Comets and Kuiper Belt Objects are left over planetary building bricks called planetesimals once abundant in the solar nebula. Via collisions and accretion of large grains, aka Pebbles, they grew into planets. The efficiency of Planetesimals formation via a gravitational collapse of Pebble clouds and the characteristics of the forming planetesimals are determined by the size distribution and local concentration of the largest grains, both",{"id":388,"funder":7,"programme":8,"title":389,"piName":10,"institution":367,"country":368,"year":13,"amount":223,"abstract":390},"cordis-european-research-council-award-101140661","Urban Frontiers. From Illegal Land Occupation to Legalized Property","No land, that government and developers see as future cities in the Global South, is vacant. There is no empty ‘no-man’s land.’ Individual citizens, social movements, squatters, and urban developers already engage in making their land use look legal. Urban property development in the Global South often starts out in illegality. Only subsequently does it become legal. This project explains how?Mainstream research on the Global South sees urban land in technical terms of rapid urbanization, and th",{"id":392,"funder":7,"programme":8,"title":393,"piName":10,"institution":394,"country":40,"year":13,"amount":395,"abstract":396},"cordis-european-research-council-award-101142747","Scaling and Concentration Laws in Information Theory","UNIVERSITAT POLITECNICA DE CATALUNYA","€2,499,995","Shannon’s 1948 paper established the mathematical foundations of digital compression and transmission and paved the way for the information age. A notion embedded in Shannon’s and most work in Information Theory is the concept of rate, defined as the exponential growth rate of the number of messages. The probabilistic law governing general information processing systems may be such that the optimal number of messages does not scale exponentially with the length of the sequences. The vast majorit",{"id":398,"funder":7,"programme":8,"title":399,"piName":10,"institution":400,"country":97,"year":13,"amount":104,"abstract":401},"cordis-european-research-council-award-101142123","Drivers and origins of high-altitude precipitation on the Third Pole","UNIVERSITEIT UTRECHT","Asia’s mountain ranges are the world’s most important water towers, often referred to as the planet’s Third Pole. Precipitation in these mountains feeds glaciers and snow fields and generates river flow, which sustains millions of people downstream. Precipitation also triggers natural hazards such as floods, landslides and avalanches, which cause enormous human and economic losses. Despite the importance of high-altitude precipitation, we lack a fundamental understanding of the mechanisms that c",{"id":403,"funder":7,"programme":8,"title":404,"piName":10,"institution":405,"country":59,"year":13,"amount":104,"abstract":406},"cordis-european-research-council-award-101141647","Self-Optimizing Static Program Analysis","UNIVERSITAET PADERBORN","Software systems pervade our personal and professional lives, yet their insecurity threaten our society. To assure that software systems are dependable and secure, one must reason about their code. Static program analysis enables such reasoning. It can be applied to individual software components, and it can show not only the presence but also prove the absence of bugs and vulnerabilities. Yet, to be useful to software developers, static analyses must be adapted to the context in which they are ",{"id":408,"funder":7,"programme":8,"title":409,"piName":10,"institution":410,"country":59,"year":13,"amount":411,"abstract":412},"cordis-european-research-council-award-101140898","Intramer-mediated multi-parallel mapping of signalling pathways","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","€2,499,241","Cellular behaviour is methodically studied using systems biology approaches that analyse the presence, absence, or oscillation of biomolecules. To this end, exogenous perturbations, among others, are used to alter protein expression and study their effects on cellular homeostasis. However, proteomes are inherently versatile and diversified by alternative splicing, protein cleavage, and post-translational modifications (PTM). Similarly, the spatiotemporal formation of multicomponent complexes pla",{"id":414,"funder":7,"programme":8,"title":415,"piName":10,"institution":416,"country":47,"year":13,"amount":417,"abstract":418},"cordis-european-research-council-award-101139967","Land use implications of the renewable energy transition","UNIVERSITE CATHOLIQUE DE LOUVAIN","€2,494,683","To mitigate climate change, most electricity production will have to come from renewable energy (RE) sources. A challenge is that RE has a much larger land footprint than conventional energy sources. Current projections of the RE transition overlook its effects on landscapes, which may lead to unanticipated spill-over effects. Spatial constraints will severely limit the expansion of RE capacity due to: (i) competition against other land uses, (ii) public opposition, and (iii) restrictive legisla",{"id":420,"funder":7,"programme":8,"title":421,"piName":10,"institution":422,"country":97,"year":13,"amount":10,"abstract":423},"cordis-european-research-council-award-101141534","Validating Biodegradation Rates and Reactions Applying Novel Technologies and Systems Ecology Approaches","STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN","Plastic Marine Debris (PMD) is now considered a planetary boundary threat and the Plastic Cycle a biogeochemical cycle. The impacts of single-use plastic litter in marine environments have prompted a search for greener alternatives such as the biodegradable\u002Fcompostable plastics polyhydroxyalkanoates and polylactic acid already being used for consumer goods. The diversity of microbes, their enzymes, and their role in influencing the rates of plastic biodegradation in nature remains poorly charact",{"id":425,"funder":7,"programme":8,"title":426,"piName":10,"institution":422,"country":97,"year":13,"amount":427,"abstract":428},"cordis-european-research-council-award-101142168","Flexible Statistical Inference","€2,499,461","Most statistical methods require that all aspects of data collection and inference are determined in advance, independently of the data. These include when to stop collecting data, what decisions can be made (e.g. accept\u002Freject hypothesis, classify new point) and how to measure their quality (e.g. loss function\u002Fsignificance level). This is wildly at odds with the flexibility required in practice! It makes it impossible to achieve error control in meta-analyses, and contributes to the replication",{"id":430,"funder":7,"programme":8,"title":431,"piName":10,"institution":432,"country":132,"year":13,"amount":433,"abstract":434},"cordis-european-research-council-award-101142677","Past Solar Storms: The links between solar storms and solar activity","LUNDS UNIVERSITET","€2,498,835","Our Sun is a remarkably stable energy source which is crucial for life on Earth. However, we know that the Sun exhibits variations on a wide range of time scales. Occasionally, violent eruptions on the Sun’s surface, so-called solar storms, release energetic particles that can damage our modern society. Nowadays the Sun is constantly monitored and a wealth of information has been obtained about its variability from ground-based and satellite observations. However, our Sun exhibits variations tha",{"id":436,"funder":7,"programme":8,"title":437,"piName":10,"institution":361,"country":59,"year":13,"amount":438,"abstract":439},"cordis-european-research-council-award-101139772","Preventing Bone Loss by Targeting Endothelial Cell-Tissue Crosstalk","€2,498,719","During healthy aging but also in osteoporosis, a disease that affects more than 22% of European women beyond the age of 50, loss of mineralized bone is caused by a disbalance between bone formation and resorption. While blood vessels are abundant in the skeletal system and play essential roles, they are currently not considered in the context of anti-osteoporosis therapy. Moreover, apart from the role of sex hormones, we know too little about the impact of sex-specific regulators in physiologica",{"id":441,"funder":7,"programme":8,"title":442,"piName":10,"institution":361,"country":59,"year":13,"amount":443,"abstract":444},"cordis-european-research-council-award-101140565","Resurrecting, re-evolving and re-inventing Rubisco: From the evolutionary past of Earth’s No. 1 CO2-fixing enzyme to its synthetic future","€2,837,483","Can we re-construct the engine of natural CO2-fixation? Rubisco catalyzes the key reaction in photosynthesis: the capture and conversion of atmospheric CO2 into biomass. However, despite billions of years of evolution the enzyme is (still) constrained by a trade-off between CO2-fixation activity and CO2-specificity, which limits photosynthetic carbon capture, and thus directly agricultural yield. In pro2neo-RUBISCO, we will overcome this fundamental limitation of photosynthetic CO2-fixation with",{"id":446,"funder":7,"programme":8,"title":447,"piName":10,"institution":361,"country":59,"year":13,"amount":448,"abstract":449},"cordis-european-research-council-award-101141844","Spectroscopy for Strain-Modulated Terahertz Magnonics","€2,968,750","Motivated by the recent discovery of a giant strain-induced blue-shift of Terahertz antiferromagnetic spin waves (magnons) in the spin-orbit Mott insulators Sr2IrO4 and Ca2RuO4 by the PI and his group, the SpecTera project will explore whether strain modulation can be harnessed to confine and guide THz magnons.  To probe magnetic order and magnon excitations in inhomogeneous strain environments with high energy and momentum resolution, we will develop a combination of Raman, Brillouin, and reson",{"id":451,"funder":7,"programme":8,"title":452,"piName":10,"institution":453,"country":66,"year":13,"amount":104,"abstract":454},"cordis-european-research-council-award-101142691","A Novel Glutamine (Q) Sensory Role for Primary Cilia: Implications for Health and Disease","OSPEDALE SAN RAFFAELE SRL","Primary cilia are single, microtubule-based, organelles protruding as antennae at the surface of most cells. Their dysfunction is associated with several genetic disorders, called the ciliopathies. We recently identified a new, previously undescribed, role for primary cilia as sensors of cellular nutrient availability. In this novel mTORC1-independent pathway, cilia directly communicate with mitochondria to drive metabolic reprogramming under nutrient stress, when glutamine (Q) becomes an obliga",{"id":456,"funder":7,"programme":8,"title":457,"piName":10,"institution":458,"country":349,"year":13,"amount":459,"abstract":460},"cordis-european-research-council-award-101142881","SelF-powerIng electroNics – the Key to Sustainable future","POLITECHNIKA WARSZAWSKA","€2,497,319","Scientific and technological achievements are often accompanied with pollution of the planet. Even electronics, believed clean, produces waste counting in trillions of batteries. We propose a solution that consists in battery-less self-supplying and thus helping to keep our planet green.Surprisingly, not only seas are exhibiting tides, the atmospheric pressure (P) and temperature (T) also do something similar. SFINKS will try to spark a new era of battery-less electronics via exploitation of the",{"id":462,"funder":7,"programme":8,"title":463,"piName":10,"institution":464,"country":59,"year":13,"amount":104,"abstract":465},"cordis-european-research-council-award-101141461","Ball-Milling Mechanochemistry at the Molecular Level-2","MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG","Ball milling mechanochemistry is receiving tremendous attention over the last years. The applicant has pioneered the use of it for effecting catalytic reactions, culminating in catalytic ammonia synthesis from H2 and N2 at room temperature and atmospheric pressure. In spite of the success in driving reactions mechanically, the molecular level understanding of the key processes under mechanical activation is still in its infancy. The proposed program will change this, using methods giving insight",{"id":467,"funder":7,"programme":8,"title":468,"piName":10,"institution":469,"country":59,"year":13,"amount":470,"abstract":471},"cordis-european-research-council-award-101141673","Harnessing the Catalytic Potential of Nitrogenases","ALBERT-LUDWIGS-UNIVERSITAET FREIBURG","€2,963,906","Biological nitrogen fixation is nature’s alternative to the industrial Haber-Bosch process that currently feeds at least half of the human world population through the provision of nitrogen fertilizers. In addition to its high energy demand, the process increasingly leads to various ecological problems, as its annual output steadily grows with demand. Haber-Bosch ammonia synthesis leads to the release of the greenhouse gases CO2 and N2O and to eutrophication of waters and aquifers because a subs",{"id":473,"funder":7,"programme":8,"title":474,"piName":10,"institution":475,"country":59,"year":13,"amount":104,"abstract":476},"cordis-european-research-council-award-101140173","Radical Chemistry with the Hydrogen Atom Through Water Activation","UNIVERSITAET MUENSTER","Water activation, which allows the transfer of universally abundant hydrogen into value added compounds, is an important research field in modern science. This task has been realized mainly by using transition-metal-based systems. Herein we will use a conceptually novel mild water activation strategy which proceeds through a photocatalytic phosphine-mediated radical process. The active species in these processes is a metal-free R3P-OH2 radical cation intermediate where both hydrogen atoms are us",{"id":478,"funder":7,"programme":8,"title":479,"piName":10,"institution":400,"country":97,"year":13,"amount":480,"abstract":481},"cordis-european-research-council-award-101141700","How a pinch of Salt makes all the Difference for Sustainable Fuels and Chemicals - The Role of Promoters to Catalyse the Production of Low Carbon Fuels","€3,500,000","Our large, non-circular use of fossil fuels is the main cause of rapid climate change and resource depletion. CO2 capture followed by conversion back into fuels would be attractive. The feasibility of this route depends critically on new catalysts that allow quick CO2 hydrogenation to desired products. Most man-made catalysts are supported metal nanoparticles. The influence of the type of metal, particle size and metal-support interaction are increasingly well understood, also due to major contr",{"id":483,"funder":7,"programme":8,"title":484,"piName":10,"institution":485,"country":97,"year":13,"amount":104,"abstract":486},"cordis-european-research-council-award-101141238","The Power of Size: How cross-disciplinary scaling transforms assessment and management of environmental risks","STICHTING RADBOUD UNIVERSITEIT","SettingOver the last decades, anthropogenic pressures on the environment have dramatically intensified and diversified. Nowadays, we have to deal with 100,000+ pollutants, species and sites. To set the right priorities among these environmental problems and to select the best alternatives among sustainable solutions, proper assessment tools are urgently needed.RelevanceWhile several models are available, application to thousands of cases is severely limited by data gaps due to financial, ethical",{"id":488,"funder":7,"programme":8,"title":489,"piName":10,"institution":490,"country":59,"year":13,"amount":491,"abstract":492},"cordis-european-research-council-award-101142155","Highly Ionized Trapped 229-Thorium:A New Paradigm Towards a Nuclear Clock","GSI HELMHOLTZZENTRUM FUR SCHWERIONENFORSCHUNG GMBH","€2,498,963","Among the more than 3000 nuclides that are naturally occurring or that have been artificially synthesized, thorium-229 is truly exceptional. Its remarkably low excitation energy makes it the ideal candidate for nuclear frequency metrology, surpassing current atomic clocks. Such a nuclear clock opens doors to fundamental physics, testing time-variations of constants and exploring the enigma of dark matter. Within HITHOR a conceptually novel methodology towards such a clock is proposed, eventually",{"id":494,"funder":7,"programme":8,"title":495,"piName":10,"institution":298,"country":33,"year":13,"amount":104,"abstract":496},"cordis-european-research-council-award-101142726","The origin and impact of impaired ubiquitin signaling in the degeneration of neurons","Neurodegenerative diseases share similar hallmarks such as protein aggregation, suggesting that impaired protein degradation may be a common denominator. The major cellular pathways mediating protein degradation are the Ubiquitin-proteasome system (UPS) and autophagy, both regulated by ubiquitin signaling. However, aside from specific mutations in familial neurodegeneration cases, an early cause for failing ubiquitin-dependent proteolysis remains unclear. This proposal will test our unconvention",{"id":498,"funder":7,"programme":8,"title":499,"piName":10,"institution":32,"country":33,"year":13,"amount":500,"abstract":501},"cordis-european-research-council-award-101141777","Isotopic Signatures of Sulfur Cycling Organism Physiology and Ecology","€2,499,928","Dissimilatory S metabolisms impart large S and O isotope fractionations, which are modulated by a suite of (bio)chemical reactions and physical processes (i.e., diagenesis) and ultimately preserved in the reduced and oxidized products of sedimentary S cycling (e.g., pyrite, carbonate-associated sulfate). The multi-isotope composition of such compounds encodes valuable information about microbial activity, environmental conditions, and elemental cycles. Robust interpretation of these signals requ",{"id":503,"funder":7,"programme":8,"title":504,"piName":10,"institution":505,"country":173,"year":13,"amount":10,"abstract":506},"cordis-european-research-council-award-101141656","Multisystem imaging of whole-body emotion circuits with total-body positron emission tomography","TURUN YLIOPISTO","The goal of the TOTALBODY project is to establish the interacting biological networks supporting human emotions and their disorders across the brain and periphery using novel total-body positron emission tomography (PET) approach. The body-to-brain axis maps visceral signals onto emotions, driving complex motivated behaviours. Negative emotions are risk factors for cardiovascular diseases (CVDs) Conversely, CVDs are associated with anxiety, highlighting the link between negative emotions, bodily",{"id":508,"funder":7,"programme":8,"title":509,"piName":10,"institution":510,"country":97,"year":13,"amount":511,"abstract":512},"cordis-european-research-council-award-101141346","FATty liver disease and  Gutmicrobial Alcohol Production  (FATGAP)","STICHTING AMSTERDAM UMC","€2,875,663","Obesity and subsequent non-alcoholic hepatic steatosis (NAFLD-NASH) are important determinants of morbidity and mortality being imbalanced between ethnicities living in Europe. However, relatively little is known about the underlying aetiology that drives NAFLD-NASH and currently no treatment is available. We and others have mapped alterations in  gut microbiota to metabolic disease, focusing on the bacterial functions. FATGAP builds on our work showing that 40% of obese humans with NAFLD-NASH a",{"id":514,"funder":7,"programme":8,"title":515,"piName":10,"institution":516,"country":173,"year":13,"amount":517,"abstract":518},"cordis-european-research-council-award-101142449","Computational Cosmology and Gravitational Waves","HELSINGIN YLIOPISTO","€2,446,893","The discovery of gravitational waves by the LIGO and Virgo collaborations opened a new window to the Universe. Space-based gravitational wave detectors, such as the LISA mission, enable an exciting opportunity: using gravitational waves from the very early Universe in the search for beyond-the-Standard-Model (BSM) particle physics.The LISA science case identifies first order phase transitions as the most promising source of cosmological gravitational waves. There are no phase transitions in the ",{"id":520,"funder":7,"programme":8,"title":521,"piName":10,"institution":516,"country":173,"year":13,"amount":522,"abstract":523},"cordis-european-research-council-award-101131356","Work without End: Informal Taxation and Forced Labor within Persian Southern Levantine Temple Economy and Society","€2,499,994","How does human work structure the economy and society? Temples in the Southern Levant during the Persian Empire (c. 539331BCE) provide a vital, underutilized historical vista for such questions. Persian involvement with labor taxation, forced labor, andtemple institutions makes temples cynosures for key ancient economic, social, and cultural practices of work. Focusing on taxationand labor, WORK-IT drags analysis from formal to informal taxation (from official to social structures) and from slav",{"id":525,"funder":7,"programme":8,"title":526,"piName":10,"institution":527,"country":40,"year":13,"amount":528,"abstract":529},"cordis-european-research-council-award-101141220","QUANTUM-ENHANCED FREE-ELECTRON SPECTROMICROSCOPY","FUNDACIO INSTITUT DE CIENCIES FOTONIQUES","€2,497,225","Ultrafast electron microscopy relies on the spatial, spectral, and temporal manipulation of free electrons with nm\u002FmeV\u002Ffs precision to map the structural dynamics as well as the vibrational and electronic ground and excited states of nanomaterials. With QUEFES I will introduce a conceptually disruptive approach to capitalize on the quantum nature of free electrons and their interactions with matter and radiation fields aiming to obtain previously inaccessible information on the atomic-scale dyna",{"id":531,"funder":7,"programme":8,"title":532,"piName":10,"institution":533,"country":59,"year":13,"amount":534,"abstract":535},"cordis-european-research-council-award-101141366","Isolating Many-Particle Correlations in Time and Space","JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG","€2,499,465","Electronic excitations are crucial in many fields of science and engineering. Time-resolved spectroscopy is widely used to detect dynamics of excited particles (electrons) and quasiparticles (e.g., excitons or plasmons). In the scheme of “femtochemistry” established since decades, one excitation is placed into the system by a pump pulse and its evolution observed by a time-delayed probe pulse. However, this does not resolve correlations between multiple excitations making it impossible to unders",{"id":537,"funder":7,"programme":8,"title":538,"piName":10,"institution":469,"country":59,"year":13,"amount":539,"abstract":540},"cordis-european-research-council-award-101142324","The organization of the archaeal cell","€2,498,000","Archaea are microbes that form one of the three domains of life. While sharing similarities with both Bacteria and Eukarya, archaea possess unique features such as atypical lipid membranes, the archaellum motility apparatus, and exclusive metabolic pathways like methanogenesis. Studies over the last decade have substantially expanded the archaeal tree of life, revealing the tremendous diversity, widespread distribution and vital ecological roles mediated by these organisms, as well as their cruc",{"id":542,"funder":7,"programme":8,"title":543,"piName":10,"institution":544,"country":59,"year":13,"amount":545,"abstract":546},"cordis-european-research-council-award-101141234","Aluminum STEAM combustion for clean energy","TECHNISCHE UNIVERSITAT DARMSTADT","€2,498,481","Metal fuels are emerging as a zero-carbon, high-energy density replacement for fossil fuels due to their availability and recyclability using renewable energy. Aluminum (Al) powder has been investigated mostly in air\u002FO2 as an additive in solid rocket engines. Recently, Al continuous pressurized combustion in steam has attracted considerable interest for on-demand co-production of high-temperature heat and H2. Combustion in pressurized steam lowers flame temperatures and minimizes emissions of un",{"id":548,"funder":7,"programme":8,"title":549,"piName":10,"institution":550,"country":97,"year":13,"amount":551,"abstract":552},"cordis-european-research-council-award-101142218","Deep genetics to study and uncover ‘hidden’ biology","STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS","€2,451,625","Human genes are organized in complex networks, to produce thousands of proteins to perform a myriad of functions. Whereas we have detailed maps for most biochemical pathways, the wiring of genetic networks in human cells is poorly understood.Development of powerful human genetic tools (CRISPR, RNAi, haploid cells), to which I made crucial contributions, have proven invaluable to study genetic networks. However, they face two major limitations. First, they provide information at the gene level, w",{"id":554,"funder":7,"programme":8,"title":555,"piName":10,"institution":556,"country":97,"year":13,"amount":557,"abstract":558},"cordis-european-research-council-award-101141866","Protein-regulated artificial cell populations and tissues","TECHNISCHE UNIVERSITEIT EINDHOVEN","€2,499,668","Artificial cells are soft matter, micron-sized compartments that display features which are normally associated with living cells only. These include aspects such as metabolism, growth and communication. Artificial cell research is motivated by the fact that the creation of synthetic compartments with lifelike features leads to a better understanding of the complexity of living cells and to the ability to design systems with interactive behavior. Research has until now been mostly focused on the",{"id":560,"funder":7,"programme":8,"title":561,"piName":10,"institution":562,"country":84,"year":13,"amount":563,"abstract":564},"cordis-european-research-council-award-101142533","Energy production and storage using biological ion transport systems","UNIVERSITE GRENOBLE ALPES","€2,858,020","This project aims to create a “green” energy storage system that integrates a biological voltage source with a biological supercapacitor to achieve large energy and power capacities in a light-weight sustainable packaging. The project re-defines the concept of “biological engineering” to be one that utilizes proteins, molecules and lipids in combination with synthetic materials to assemble the smart micro\u002Fnanostructured energy storage system. There are at least four advantages to this “biologica",{"id":566,"funder":7,"programme":8,"title":567,"piName":10,"institution":568,"country":84,"year":13,"amount":569,"abstract":570},"cordis-european-research-council-award-101141564","Mohorovičić discontinuity and Lithosphere-Asthenosphere Boundary","INSTITUT DE PHYSIQUE DU GLOBE DE PARIS","€3,498,250","The Moho and lithosphere-asthenosphere boundary (LAB) are two of the most important boundaries in the Earth. The Moho is the greatest manifestation of the chemically differentiated Earth, separating light rocks in the crust from dense rocks in the mantle whereas the LAB is fundamental for plate tectonics, defining the boundary between the floating rigid lithosphere and the weak, deformable asthenosphere. They are both first born at mid-ocean ridges, where two-thirds of the Earth’s crust and lith",{"id":572,"funder":7,"programme":8,"title":573,"piName":10,"institution":103,"country":97,"year":13,"amount":10,"abstract":574},"cordis-european-research-council-award-101142157","Targeted Re-engineering of the Tumor Matrix to Advance Immunotherapy","Immunotherapy can prolong lives of cancer patient subgroups, but fails in solid tumors with dense fibrotic stroma, such as pancreatic cancer. Fibrotic stroma prevents the recruitment and activation of immune effector cells, and, thereby dampens the efficacy of immunotherapy. Mechanistically, cancer-associated fibroblasts (CAFs) initiate extracellular matrix (ECM) production, which aggravates fibrosis by reciprocal mechanoactivation and crosstalk with tumor-associated myeloid cells, forming a sel",{"id":576,"funder":7,"programme":8,"title":577,"piName":10,"institution":578,"country":59,"year":13,"amount":579,"abstract":580},"cordis-european-research-council-award-101141570","Kinase Regulation by Phase Separation","DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV","€2,499,943","Protein phosphorylation is a process that activates biological and cellular pathways. This process is carried out by enzymes called protein kinases that add phosphates to proteins. Protein kinases are crucial drug targets involved in the onset and progression of human diseases such as cancer and Alzheimers disease. Growing evidence suggests that protein kinases are regulated spatially and temporally by the phase separation and condensation of biomolecules into cellular organelles that are not su",{"id":582,"funder":7,"programme":8,"title":583,"piName":10,"institution":584,"country":40,"year":13,"amount":585,"abstract":586},"cordis-european-research-council-award-101142260","Maximizing the use of a first clinically viable MYC inhibitor","FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO)","€2,499,904","Even though the MYC oncogene is a “most-wanted” target in cancer therapy, no MYC inhibitor has yet reached clinical approval. The applicant has developed Omomyc, the first MYC-inhibiting mini-protein to have successfully completed a Phase Ia clinical trial. The goal of this proposal is to maximise the use of this compound, as both a therapeutic and study tool, opening new lines of research in different aspects of MYC biology.To start with, since Omomyc cannot efficiently cross the blood brain ba",{"id":588,"funder":7,"programme":8,"title":589,"piName":10,"institution":590,"country":59,"year":13,"amount":591,"abstract":592},"cordis-european-research-council-award-101141922","Effective Field Theories to understand and predict  the Nature of the XYZ Exotic Hadrons","TECHNISCHE UNIVERSITAET MUENCHEN","€2,312,500","Two decades ago, the eld of strongly interacting particles entered a golden age with the discovery of exotic hadrons labeled as XYZs. The breakthrough fueled a surge in experimental research, uncovering dozens of states that appear to lie outside the conventional quark model, although some still require experimental conrmation. The plethora of new states has sparked intense theoretical investigations into new forms of matter, such as quark-gluon hybrids, mesonic molecules, and tetraquarks, makin",{"id":594,"funder":7,"programme":8,"title":595,"piName":10,"institution":432,"country":132,"year":13,"amount":596,"abstract":597},"cordis-european-research-council-award-101141836","Global reanalysis for a forest carbon sink in flux","€2,499,226","Three trillion trees lie behind a carbon sink that has taken up about 30% of humanity’s carbon emissions over recent decades. Yet whether we can continue to rely on this huge natural subsidy is highly uncertain. The sink emerges from systematic perturbations in the dynamics of growth, death and establishment of individual trees. Taken together across the forest, these lead to the net uptake or release of carbon. Both theory and recent observations point towards profound changes in these dynamics",{"id":599,"funder":7,"programme":8,"title":600,"piName":10,"institution":172,"country":173,"year":13,"amount":104,"abstract":601},"cordis-european-research-council-award-101142496","Life-Inspired Soft Matter","To fulfil the quest for increasingly functional materials, biology has already offered inspiration towards advances in materials science. So far, bioinspired materials include, e.g., liquid- and dirt-repelling surfaces, structural colours, biomimetic composites, strong fibers, tissue templating, and underwater adhesives. On the other hand, stimulus-responsive, shape memory, and reconfigurable materials have been presented with switchable functional properties. They are typically in global or loc",{"id":603,"funder":7,"programme":8,"title":604,"piName":10,"institution":605,"country":66,"year":13,"amount":104,"abstract":606},"cordis-european-research-council-award-101140720","Inter materials and structures mechanoperception for self learning","POLITECNICO DI MILANO","Forests, insect swarms, bones during remodeling, are striking examples of biological systems whose elements possess the ability to sense and exchange signals. These signals are exploited to adapt to evolving environmental conditions and to learn how to improve performance, in some cases without a centralized control.Can materials and structures be enabled with the same capabilities? How can we build devices that exchange information on a mechanistic base and exploit these to learn how to optimal",{"id":608,"funder":7,"programme":8,"title":609,"piName":10,"institution":610,"country":47,"year":13,"amount":611,"abstract":612},"cordis-european-research-council-award-101141569","Allosteric modulation of immune checkpoint complexes as a new mode of therapeutic intervention in immunotherapy","VIB VZW","€2,499,674","The fastidious balance of our immune system to fight infections or cancer while avoiding autoimmune reactions is regulated by coinhibitory and co-stimulatory immune checkpoint complexes (ICCs), which have become major drug targets. We witness the skyrocketing progression in cancer immunotherapy with antibodies that block inhibitory ICCs whereas Abs that block stimulatory ICCs are in clinical trials for treating autoimmune diseases.Surprisingly, but likely fuelled by the most obvious focus on IC ",{"id":614,"funder":7,"programme":8,"title":615,"piName":10,"institution":616,"country":66,"year":13,"amount":104,"abstract":617},"cordis-european-research-council-award-101141363","Acquired adaptive immune cell dysfunction and restoration in chronic hepatitis B","UNIVERSITA VITA-SALUTE SAN RAFFAELE","This proposal aims to investigate the development of dysfunctional adaptive immune cells during chronic hepatitis B virus (HBV) infection and to develop new strategies to reprogram them into functional cells with potent antiviral activity. Our hypothesis, based on extensive preliminary data, is that HBV induces a unique type of adaptive immune cell dysfunction that differs from that observed in other viral infections or cancer. To investigate this, we will use unique mouse models of HBV pathogen",{"id":619,"funder":7,"programme":8,"title":620,"piName":10,"institution":621,"country":40,"year":13,"amount":104,"abstract":622},"cordis-european-research-council-award-101142365","RNA-based cancer ImmunotheraPeutics to Enhance CROssPrimming","FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA","Cancer immunotherapy achieves unprecedented efficacy against a number of malignant diseases. Preclinical experiments in mouse models conclude that type-1 dendritic cells (cDC1) that present tumor antigens are an absolute requirement for most immunotherapy strategies to be efficacious, including those routinely applied to cancer patients at present. cDC1 cells are specialized in redirecting engulfed cell-associated antigens to the class I MHC antigen-presentation pathway in the context of IL-12 p",{"id":624,"funder":7,"programme":8,"title":625,"piName":10,"institution":550,"country":97,"year":13,"amount":104,"abstract":626},"cordis-european-research-council-award-101141245","Causes and consequences of aberrant mRNA translation in cancer","Shortages in amino acids are weapons in the warfare between tumor cells and tumor-infiltrating lymphocytes. Tumor cells enhance or inhibit the production of key amino acid metabolites to stimulate oncogenesis and suppress anti-tumor activity. A key player in this battle is tryptophan. Activated T cells secrete interferon-, which upregulates IDO1 enzyme to catabolize tryptophan to kynurenine in target tumor cells. While kynurenine suppresses T-cell function, its production limits tryptophan avail",{"id":628,"funder":7,"programme":8,"title":629,"piName":10,"institution":630,"country":84,"year":13,"amount":631,"abstract":632},"cordis-european-research-council-award-101141890","Economics of Health Care Markets and Innovation","FONDATION JEAN JACQUES LAFFONT,TOULOUSE SCIENCES ECONOMIQUES","€1,421,250","Medical progress over the last century has undoubtedly improved our well-being. However, the equal access to health care and its economic sustainability are challenged by the scientific revolutions of genetics, the nature and extent of new risks and the growing externalities across countries that put at risk the production of health care public goods. The development of new cell and gene technologies holds the potential for creating therapies for conditions like cancers and genetic diseases. How",{"id":634,"funder":7,"programme":8,"title":635,"piName":10,"institution":636,"country":59,"year":13,"amount":104,"abstract":637},"cordis-european-research-council-award-101142296","Remote controlling biological systems by sonopharmacology and sonogenetics","DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV","To date, light has been employed as a widespread trigger to achieve control over the activity of drugs and protein function establishing the fields of photopharmacology and optogenetics, respectively. Both techniques led to promising new therapies, the elucidation of brain function or understanding of neural disorders. However, serious limitations resulting from the low penetration depth of light into tissues are severely hampering progress in these fields. In contrast to photons, ultrasound dee",{"id":639,"funder":7,"programme":8,"title":640,"piName":10,"institution":641,"country":84,"year":13,"amount":642,"abstract":643},"cordis-european-research-council-award-101142062","Microbiota-controlled trafficking of immunosuppressive intestinal T cells into cancer","INSTITUT GUSTAVE ROUSSY","€2,487,834","Resistance of cancers to immune checkpoint blockade (ICB) can result from a deviated taxonomic composition of the intestinal microbiota. A surge in the Enterocloster genus, for instance following discontinuation of antibiotics or chronic inflammation caused by tumors, induces the downregulation of MAdCAM-1 in the ileal lamina propria and mesenteric lymph nodes through perturbations of biliary salts. In turn, the ileal MAdCAM-1 loss induces the exodus of immunosuppressive T lymphocytes expressing",{"id":645,"funder":7,"programme":8,"title":646,"piName":10,"institution":647,"country":260,"year":13,"amount":648,"abstract":649},"cordis-european-research-council-award-101142626","Antibiotics of the future: are they prone to bacterial resistance?","HUN-REN SZEGEDI BIOLOGIAI KUTATOKOZPONT","€3,479,716","Although several new antibiotic candidates are in the clinical pipeline, the future evolution of resistance in bacteria may render them ineffective. This project aims to develop a framework for forecasting the long-term effectiveness of new antibiotic candidates. For this purpose, we will decipher the general principles shaping bacterial resistance to a wide range of antibiotic candidates currently in development. Using recently developed methods in our laboratory, we will study resistance evolu",{"id":651,"funder":7,"programme":8,"title":652,"piName":10,"institution":653,"country":97,"year":13,"amount":104,"abstract":654},"cordis-european-research-council-award-101142063","Restoring the structural collagen network in the regeneration of cartilage","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","How can we durably regenerate damaged tissues in our body? At present, the answer to this question is largely unknown. Cell-based tissue engineering approaches can be used to produce living implants in the laboratory with a composition that is not unlike real tissues. However, the collagen-based matrix within such structures often lacks the specific intricate organisation that is imperative for the required biomechanical properties, functionality and mechanical stability. This is the cause of ou",{"id":656,"funder":7,"programme":8,"title":657,"piName":10,"institution":658,"country":97,"year":13,"amount":104,"abstract":659},"cordis-european-research-council-award-101141130","Receptor Recruitment as an Organizational Principle for Self-Assembling Matter","UNIVERSITEIT TWENTE","Receptor recruitment occurs in biology as a response to binding, for example, by virus particles to a cell membrane. The interactions that underlie the binding process are typically multivalent in nature, in other words, multiple interactions of the same motif occur simultaneously to provide a collective, cooperative effect. This project aims to employ recruitment as a design criterium for self-assembling building blocks into well-defined architectures. Intrinsically weak and dynamic interaction",{"id":661,"funder":7,"programme":8,"title":662,"piName":10,"institution":663,"country":349,"year":13,"amount":664,"abstract":665},"cordis-european-research-council-award-101142236","Typical and Atypical structures in quantum theory","UNIWERSYTET JAGIELLONSKI","€2,253,125","Quantum theory, confirmed in numerous sophisticated experiments, is widely believed to describe our world at the micro scale. It is thus legitimate to investigate, which structures are allowed by quantum theory, and which of them can potentially be relevant for developments of quantum technologies.The basic notion of a quantum state  a mathematical tool used to compute probabilities, characterizing the outcomes of a quantum measurement  is of a primary importance. Furthermore, one analyses quant",{"id":667,"funder":7,"programme":8,"title":668,"piName":10,"institution":669,"country":59,"year":13,"amount":670,"abstract":671},"cordis-european-research-council-award-101141561","Targeting mechanisms of Thrombo-inflammation","UNIVERSITAET LEIPZIG","€2,499,000","The recent Covid-19 pandemic dramatically illustrated (i) the clinical relevance of thrombo-inflammation (the interplay of coagulation and inflammation) and (ii) our limited understanding of molecular mechanisms of thrombo-inflammation. Thrombo-inflammation is a frequent disease-driving mechanism, impairing out-come of viral or bacterial infection, cardiovascular disease, cancer and other diseases. The lack of mechanistic insights hampered the development of specific therapies. My group recently",{"id":673,"funder":7,"programme":8,"title":674,"piName":10,"institution":675,"country":132,"year":13,"amount":676,"abstract":677},"cordis-european-research-council-award-101142217","The Shrinking Stock Market, Investibility, and Creative Destruction","HANDELSHOGSKOLAN I STOCKHOLM","€2,489,025","There are ever fewer listed firms in the U.S. and Europe, and listed firms produce an ever shrinking share of innovation. Over the past 25 years, the number of firms listed on a stock exchange has dropped by 41% in the U.S. and 55% in Europe. At the same time, listed firms account for a shrinking share of the highly disruptive inventions that have the most potential to boost productivity and growth. In the U.S., for example, listed firms account for only 8% of the most ground-breaking patents to",{"id":679,"funder":7,"programme":8,"title":680,"piName":10,"institution":681,"country":84,"year":13,"amount":10,"abstract":682},"cordis-european-research-council-award-101142116","Molecular mimicry and immune evasion in malaria parasites","INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT","Parasites have evolved elaborate strategies that maximise their fitness. Central to these strategies is their interaction with the host immune system, for instance with immune receptors which mediate pathogen recognition or immune tolerance. Human malaria parasites encode a family of ~200 rifins, some of which are molecular mimics of human self-identifying proteins and that bind tolerance-inducing receptors. However, very few host targets of rifin proteins are known. Our data suggests that the f",{"id":684,"funder":7,"programme":8,"title":685,"piName":10,"institution":686,"country":132,"year":13,"amount":10,"abstract":687},"cordis-european-research-council-award-101142895","Inequality and Integration","STIFTELSEN INSTITUTET FOR FRAMTIDSSTUDIER","Socioeconomic inequality has become increasingly intertwined with immigrant status in many Western European societies. One important question is whether and how socioeconomic disadvantages among immigrant parents hamper the integration of their children. This project focuses on inequality and spatial segregation, and how they affect the children of immigrants in terms of their wellbeing and structural, social and cultural integration. We ask how integration in different dimensions comes to be, a",{"id":689,"funder":7,"programme":8,"title":690,"piName":10,"institution":691,"country":59,"year":13,"amount":692,"abstract":693},"cordis-european-research-council-award-101142269","Gravitational wave detectors cooled with superfluid helium","KARLSRUHER INSTITUT FUER TECHNOLOGIE","€3,379,661","GRAVITHELIUM addresses the central technology challenge in third generation gravitational wave (3G GW) detectors, proposing to cool the core optics of cryogenic detectors with superfluid helium. The Einstein Telescope (ET) will be the future European 3G GW observatory, designed to observe the whole Universe. It has entered the European ESFRI Roadmap in 2021 and is supported by the major international roadmaps. ET includes new technological challenges on the verge of feasibility, particularly in ",{"id":695,"funder":7,"programme":8,"title":696,"piName":10,"institution":697,"country":97,"year":13,"amount":104,"abstract":698},"cordis-european-research-council-award-101142180","Light on our dark past: Elucidating the deep archaeal roots of eukaryotic cellular complexity","WAGENINGEN UNIVERSITY","The origin of the eukaryotic cell, with its complex and compartmentalized features, represents a prime hallmark in the evolution of life on Earth. Yet, important details underpinning the emergence of cellular complexity of eukaryotic cells remain thus far unresolved. Current views support evolutionary scenarios in which the first eukaryotic evolved via a merger between an archaeal host cell and one or more bacterial endosymbionts. Recent phylogenomic work from my lab has shown that the archaeal ",{"id":700,"funder":7,"programme":8,"title":701,"piName":10,"institution":697,"country":97,"year":13,"amount":104,"abstract":702},"cordis-european-research-council-award-101141742","Digging Deep: An Underground Plant Trait Perspective on Diversity-Disease Relationships","Plant species diversity is often associated with reduced disease risk. Yet, the scientific literature on diversity-disease relationships is unclear, showing conflicting relationships. This conflict highlights a major knowledge gap in our understanding of the mechanisms underpinning the diversity-disease relationships. Overcoming this gap is essential for transforming agricultural systems from monocultures that are sensitive to disease outbreaks to diverse cropping systems that are intrinsically ",{"id":704,"funder":7,"programme":8,"title":705,"piName":10,"institution":706,"country":40,"year":13,"amount":10,"abstract":707},"cordis-european-research-council-award-101140786","Physical modelling of stellar activity effects to discover and measure exoearths","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","Exoplanet research has experienced enormous growth and is now pushing instrumental limits to find temperate terrestrial planets and precisely characterise their atmospheres. Extreme-precision radial velocity (RV) instruments (e.g. ESPRESSO), offering 10 cm\u002Fs stability, and space telescopes (e.g. JWST, Ariel), attaining relative flux uncertainties of 10 ppm are becoming a reality. But there is a shadow of concern hovering over such fantastic performances. The intrinsic variability of the stellar ",{"id":709,"funder":7,"programme":8,"title":710,"piName":10,"institution":706,"country":40,"year":13,"amount":711,"abstract":712},"cordis-european-research-council-award-101097431","A Novel Approach to New Family-Forms, Assisted Reproductive Technologies and Transnationalism.  A multi-sited ethnography: Spain, Denmark, Canada and Israel","€2,039,969","The global assisted reproductive technologies (ARTs) market is expected to reach USD 45 billion by 2025 with more than 8 million babies born. Europe dominates the market followed by North-America and Asia.  However more than half of European states and most countries in the Americas and Asia prohibit access to ARTs to solo individuals, same-sex couples and heterosexual couples who need donated eggs, embryos or surrogacy. It is a prime example of contemporary technological transnationalism with p",{"id":714,"funder":7,"programme":8,"title":715,"piName":10,"institution":716,"country":66,"year":13,"amount":717,"abstract":718},"cordis-european-research-council-award-101141690","Enhancing the Potential of Enzymatic Catalysis with Light","ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA","€2,945,000","One pressing challenge of chemical research is to develop new processes that responsibly use natural resources to produce added-value chiral molecules. PHOTOZYME seeks to provide solutions by combining photocatalysis, biocatalysis, and organocatalysis. These three modern strategies offer powerful tools for the sustainable preparation of chiral molecules. To date, however, they have remained largely unconnected. This proposal aims to bridge these fields in order to address major problems in asymm",{"id":720,"funder":7,"programme":8,"title":721,"piName":10,"institution":722,"country":84,"year":13,"amount":723,"abstract":724},"cordis-european-research-council-award-101097738","Biological Isotopy of Lithium in Littoral Zones","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€3,182,574","Lithium (Li) is key in the energy transition and massively used to produce mobile devices and electrical vehicles. Yet its current consumption rate exceeds its river flux to the ocean, and it is poorly recycled, while Li excess is toxic for aquatic life and humans. Although concentrations of Li and its isotopes have been measured in coastal waters, at river outlets, to study continental chemical weathering and climate controls, Li monitoring has been occasional. Moreover, bias caused by anthropo",{"id":726,"funder":7,"programme":8,"title":727,"piName":10,"institution":728,"country":84,"year":13,"amount":104,"abstract":729},"cordis-european-research-council-award-101095736","Improving flower attractiveness for pollinators:  Study of developmental, morphological and chemical cues  in relation to bee foraging","INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT","Animal pollinators are vital for life on earth. While human population keeps growing, pollinator populations are dropping, thus threatening food security. In agriculture, the main insect pollinators are bees, by far.The lack of knowledge on how domesticated plants attract and reward bees has hampered the selection of varieties with improved and mutually beneficial crop-pollinator relationships. We propose to investigate flower features, including developmental, morphological and chemical cues, i",{"id":731,"funder":7,"programme":8,"title":732,"piName":10,"institution":733,"country":12,"year":13,"amount":734,"abstract":735},"cordis-european-research-council-award-101141807","Brain fluids - Transport and clearance","SIMULA RESEARCH LABORATORY AS","€2,493,750","Scientific breakthroughs in neuroscience explain the need for sleep and the development of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases in terms of fluid dynamics: the waste created during the day is cleared away as we sleep or it accumulates. However, a decade of research after the original theory was posed has revealed that the underlying physical mechanisms are still not understood and that the advanced mathematical tools are needed.In this project we propose a rese",{"id":737,"funder":7,"programme":8,"title":738,"piName":10,"institution":739,"country":84,"year":13,"amount":740,"abstract":741},"cordis-european-research-council-award-101097791","Destabilizing vascular colonization to stop meningitis","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","€2,477,250","Before the antibiotic era chances of survival to bacterial meningitis were minimal. Nevertheless, nearly 100 years later, surprisingly little progress has been made and mortality rates currently remain unacceptably high (10-25%). Supported by clinical and experimental data, the central concept of the Destop project is that bacteria rapidly become insensitive to antibiotics during infection, which leads to treatment failure. We hypothesize that the emergence of such antibiotic insensitivity resul",{"id":743,"funder":7,"programme":8,"title":744,"piName":10,"institution":745,"country":66,"year":13,"amount":746,"abstract":747},"cordis-european-research-council-award-101142614","Genome topology and mechanical stress","CONSIGLIO NAZIONALE DELLE RICERCHE","€2,493,665","The nucleus is the stiffest organelle in the cell and is constantly challenged by intrinsic and extrinsic forces that deform the nuclear envelope.  Chromosomes are mechanical objects that can sense, transduce and adsorb mechanical forces. Inter-chromosomal contacts and nuclear envelope-associated domains contribute to transduce mechanical stress when cells experience compression, stretching or interstitial migration. We aim to study the mechanical properties of the chromosomes and how genome int",{"id":749,"funder":7,"programme":8,"title":750,"piName":10,"institution":751,"country":59,"year":13,"amount":752,"abstract":753},"cordis-european-research-council-award-101097906","Heritage of Disease: The Art and Architectures of Early Modern Hospitals in European Cities","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€2,499,450","After the Black Death of 1348, hospitals were newly designed to face social disease, further plague’s waves, and new illnesses, e.g. syphilis. Social distancing (like recently with an unknown virus) was the main method to avoid all kinds of contagion. New spatial and safety concepts were developed to care and confine the sick and the poor in structures enhancing the visibility of political or religious agendas. While wars and early globalization contributed to spreading pandemics, charitable bod",{"id":755,"funder":7,"programme":8,"title":756,"piName":10,"institution":757,"country":758,"year":13,"amount":759,"abstract":760},"cordis-european-research-council-award-101141410","Hidden metastable mesoscopic states  in quantum materials","INSTITUT JOZEF STEFAN","SI","€2,422,253","Non-equilibrium states of matter have become of great fundamental and practical interest in recent years because of their wide importance in diverse areas of physics. With the rapid development of new time-resolved techniques, the temporal dynamics of competing processes and interactions were recently elucidated in a wide variety of complex condensed matter systems. However, the physics of metastable mesoscopically non-periodic quantum textures emerging from phase transitions has been largely ex",{"id":762,"funder":7,"programme":8,"title":763,"piName":10,"institution":764,"country":765,"year":13,"amount":480,"abstract":766},"cordis-european-research-council-award-101097830","Architecture of Peripheral Neuroimmune Circuits and Synapses","FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD","PT","Maintenance of health requires the coordination of multiple cellular networks. For example, the immune and nervous systems cooperate to regulate tissue homeostasis. In agreement, our recent work demonstrates that innate lymphoid cells (ILC) integrate neuronal signals to control tissue health and immunity. These findings are provoking a paradigm shift in our understanding of the immune response, neuroimmune crosstalk and its potential therapeutic value. Nevertheless, the dynamics of neuroimmune m",{"id":768,"funder":7,"programme":8,"title":769,"piName":10,"institution":722,"country":84,"year":13,"amount":770,"abstract":771},"cordis-european-research-council-award-101095380","How plant cells set the tempo of rhythmic shoot construction","€3,378,750","Time is central to the development of the body plan of multicellular organisms. One prominent developmental timing mechanism is the rhythmic, iterative addition of tissues and organs. While the tempo of rhythmic construction is often set by developmental clocks, plants use a unique mechanism in the shoot, whereby rhythmic organogenesis emerges from dynamic changes in the distribution of the hormone auxin. High auxin levels trigger organogenesis but, contrary to a long-standing theory, the period",{"id":773,"funder":7,"programme":8,"title":774,"piName":10,"institution":775,"country":97,"year":13,"amount":776,"abstract":777},"cordis-european-research-council-award-101095574","Hyperfine coupled spins with time evolution readout","TECHNISCHE UNIVERSITEIT DELFT","€2,498,741","Quantum simulation is a promising strategy for understanding the behaviour of quantum systems that are too complex to be calculated directly. HYPSTER will make crucial steps towards creating a quantum simulator from individual magnetic atoms, addressed by means of a scanning tunnelling microscope. I will engineer atomic structures combining electron and nuclear spins  coupled to each other via hyperfine interaction  and read out their collective quantum coherent evolution in real time.The lifeti",{"id":779,"funder":7,"programme":8,"title":780,"piName":10,"institution":781,"country":782,"year":13,"amount":783,"abstract":784},"cordis-european-research-council-award-101097834","Functional Nanoscale Therapeutics","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","IE","€2,499,796","We will develop new functional nanoscale medicines that engage and co-operate with cellular pathways that were designed to process and extract useful information from endogenous nanostructures, as well as protect the organism from nanoscale pathogens. We show how functional hybrid nanostructures, part-synthetic and part-cell-derived biomolecular condensate,  elicit the full repertoire of cellular processing steps. In particular the enabling of highly efficient escape from endosomes and providing",{"id":786,"funder":7,"programme":8,"title":787,"piName":10,"institution":788,"country":368,"year":13,"amount":789,"abstract":790},"cordis-european-research-council-award-101093188","Machine learning for decision making under uncertainty","DANMARKS TEKNISKE UNIVERSITET","€2,491,210","Many important decisions are taken under uncertainty since we do not know the development of various parameters. In particular the ongoing green transition requires large and urgent societal investments in new energy modes, infrastructure and technology. The decisions are spanning over a very long time-horizon, and there are large uncertainty towards energy prices, demand of energy, and production from renewable sources. Such problem can be described as two-stage stochastic optimization problems",{"id":792,"funder":7,"programme":8,"title":793,"piName":10,"institution":722,"country":84,"year":13,"amount":794,"abstract":795},"cordis-european-research-council-award-101097804","Crystalline Oxides Platform for Hybrid Silicon Photonics","€2,499,986","Silicon (Si) photonics stands as a solid candidate to address the scaling challenges of emerging communication systems with an ever-growing number of interconnected devices. However, Si has major physical limitations that prevent on-chip integration of key functions: strong two-photon absorption limiting nonlinear optical devices, Si centrosymmetry preventing fast optical modulation, and an indirect bandgap nature hindering light emission and amplification. The common solution to overcome these ",{"id":797,"funder":7,"programme":8,"title":798,"piName":10,"institution":432,"country":132,"year":13,"amount":104,"abstract":799},"cordis-european-research-council-award-101096455","Novel biomarkers for improving diagnostics, prognostics, and treatments of Alzheimer’s disease","Alzheimer’s disease (AD) is the most common cause of dementia and a major global health challenge. AD has a long pre-symptomatic phase spanning several decades. The accuracy of clinical AD diagnostics is mediocre, especially in primary care. This results in suboptimal treatment and care, which is especially problematic in light of emerging anti-amyloid therapies. ADVANCE-AD aims to revolutionize AD diagnostics and prognostics and fast-track the development of new effective therapies by using nov",{"id":801,"funder":7,"programme":8,"title":802,"piName":10,"institution":803,"country":40,"year":13,"amount":804,"abstract":805},"cordis-european-research-council-award-101097924","Climate Policy vs Economic Growth: Opinions, Models, and Novel Strategies","UNIVERSITAT AUTONOMA DE BARCELONA","€2,454,000","Climate change has revived the debate on growth-vs-environment which may intensify in coming years. This project studies to what extent concerns about economic growth, ranging from pro- to anti-growth, hamper social-political support for ambitious climate policy, and how this can be amended. Using surveys, experiments and interviews, it assesses whether beliefs about growth-vs-environment affect policy opinions of distinct stakeholders (voters, policymakers, journalists, etc.), and if this is mo",{"id":807,"funder":7,"programme":8,"title":808,"piName":10,"institution":751,"country":59,"year":13,"amount":809,"abstract":810},"cordis-european-research-council-award-101097810","The geometrical and physical basis of cell-like functionality","€2,498,813","Can systems with life-like properties be built from scratch with only a minimal set of components? While progress has been made experimentally in the development of such minimal systems, there is a lack of theoretical underpinnings that could provide mechanistic principles. My goal is to discover such principles by combining theoretical modeling and in-silico evolution to explore the potential for life-like functions of minimal systems consisting of only two core elements of cells: reaction comp",{"id":812,"funder":7,"programme":8,"title":813,"piName":10,"institution":814,"country":758,"year":13,"amount":815,"abstract":816},"cordis-european-research-council-award-101096208","Quantum Ergodicity: Stability and Transitions","UNIVERZA V LJUBLJANI","€1,944,625","We shall develop methods and models for analyzing quantum ergodicity in many-body systems, proving its stability against small perturbations, and studying ergodicity-breaking transitions due to integrability, disorder, or localized impurities. Ergodicity is a cornerstone of statistical mechanics and a key manifestation of many-body quantum chaos, while manipulating ergodicity and engineering ergodicity-breaking transitions will have immense applications (cf.scarred states in Rydberg arrays, heat",{"id":818,"funder":7,"programme":8,"title":819,"piName":10,"institution":820,"country":59,"year":13,"amount":821,"abstract":822},"cordis-european-research-council-award-101098279","Delineating the boundary between the computational power of quantum and classical devices","FREIE UNIVERSITAET BERLIN","€1,807,721","This project sets out to assess, make use of and verify the computational power of realistic quantum devices. It comprehensively identifies quantum simulators and paradigmatic quantum devices that are computationally superior to classical supercomputers, based on presently available or plausible physical architectures. In doing so, it explores the fine line that discriminates regimes featuring a quantum advantage from ones that are accessible to efficient classical simulation. This naturally two",{"id":824,"funder":7,"programme":8,"title":825,"piName":10,"institution":373,"country":97,"year":13,"amount":826,"abstract":827},"cordis-european-research-council-award-101097553","Resilient Cultures – Music, Art, and Cinema in Mainland China and Hong Kong","€2,497,500","How to be critical in a context where critique is disavowed? How to speak against power while being silenced? How to stay amidst suppression? RESCUE studies how cultural practices in the domains of popular music, contemporary art, and queer cinema, in mainland China and Hong Kong, develop resilient tactics to express their social and political discontent. It theorises resilience and cultural critique in times of intensified authoritarianism and rapid platformization. Whereas such practices can r",{"id":829,"funder":7,"programme":8,"title":830,"piName":10,"institution":831,"country":97,"year":13,"amount":832,"abstract":833},"cordis-european-research-council-award-101096087","Gas flows in and out of galaxies: solving the cosmic baryon cycle","RIJKSUNIVERSITEIT GRONINGEN","€2,499,424","Galaxy formation is driven by the flows of gas in and out of galaxies, which remain poorly understood. Galaxies grow and fuel their star formation through the accretion of new gas, while stellar and AGN activities eject copious amount of gas into the environment. The physics of and interplay between these phenomena (cosmic baryon cycle) are extremely complex, with the consequence that our current understanding of how and when gas flows take place and their impact on the life-cycle of galaxies is",{"id":835,"funder":7,"programme":8,"title":836,"piName":10,"institution":527,"country":40,"year":13,"amount":837,"abstract":838},"cordis-european-research-council-award-101097313","Field Sensors with Exceptional Energy Resolution","€2,402,831","Field-SEER will develop magnetic sensors with combined spatial, temporal, and field resolution beyond what is possible with existing sensing approaches. The “energy resolution” of a sensor describes this combined performance, and determines a sensor’s ability to detect weak, localized and transient signals. In today’s best-developed sensors, the energy resolution is known to be limited by a combination of intrinsic quantum noise and self-interaction effects. Field-SEER will develop sensors that ",{"id":840,"funder":7,"programme":8,"title":841,"piName":10,"institution":842,"country":66,"year":13,"amount":843,"abstract":844},"cordis-european-research-council-award-101096035","POLarization Orientation CALibrator for Cosmology","UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA","€2,418,281","I will enable groundbreaking results for cosmology and fundamental physics, thanks to a novel method for measuring the angle of the polarization plane of the Cosmic Microwave Background (CMB) photons with unprecedented accuracy. Existing and planned CMB polarimeters looking for primordial B-mode signals need an independent, experimental method for systematics control on the absolute polarization orientation. The lack of such a method limits the accuracy of the detection of inflationary gravitati",{"id":846,"funder":7,"programme":8,"title":847,"piName":10,"institution":485,"country":97,"year":13,"amount":848,"abstract":849},"cordis-european-research-council-award-101096659","Making sense of the senses: Causal Inference in a complex dynamic multisensory world","€2,499,527","To interact effectively with the complex dynamic and multisensory world (e.g. traffic) the brain needs to transform the barrage of signals into a coherent percept. This requires it to solve the causal inference or binding problem - deciding which signals come from common sources and integrating those accordingly. Doing so exactly (i.e. optimally) is wildly computationally intractable for all but the simplest laboratory scenes. It is unknown how the brain computes approximate solutions for realis",{"id":851,"funder":7,"programme":8,"title":852,"piName":10,"institution":516,"country":173,"year":13,"amount":104,"abstract":853},"cordis-european-research-council-award-101097545","Coevolutionary Consequences of Biodiversity Change","Anthropogenic global change is reshaping planetary biodiversity patterns at an accelerating rate. The diverse and non-linear ways in which species respond to global change can lead to non-obvious alterations in the structure and intensity of species interactions. However, the extent to which coevolutionary dynamics are disrupted under biodiversity change remains largely unknown. Interspecific interactions are the key determinants of biodiversity and ecosystem functioning, and their modifications",{"id":855,"funder":7,"programme":8,"title":856,"piName":10,"institution":400,"country":97,"year":13,"amount":857,"abstract":858},"cordis-european-research-council-award-101097322","Infrastructural Imperialism: Global 'Big Brothers' and Geopolitical Futures","€2,499,510","In early European imperialism, trade and resource exploitation financed lavish building projects in metropolitan centers and fueled further colonial expansion. Today, rising economic powers such as Turkey, China, and Brazil rely on building the infrastructure of other states to drive reconstruction in their own capitals and create “soft power” empires. INFRAEMPIRE will turn an ethnographic lens on the infrastructural imperialism of the Turkish state, a growing power whose construction sector is ",{"id":860,"funder":7,"programme":8,"title":861,"piName":10,"institution":862,"country":132,"year":13,"amount":104,"abstract":863},"cordis-european-research-council-award-101097367","The sequencing microscope - a path to look at the molecules of biology","KAROLINSKA INSTITUTET","The goal of biological research is to understand how life works. Although progress is fast, there seems to be an infinity of things we do not understand. When it comes to understanding tissue from the bottom up, our knowledge leaves much to desire. Feynman claimed that “It is very easy to answer many of these fundamental biological questions; you just look at the thing!” well the problem is that looking at the thing is the problem. Microscopy might never give us the possibility to directly see D",{"id":865,"funder":7,"programme":8,"title":866,"piName":10,"institution":867,"country":40,"year":13,"amount":868,"abstract":869},"cordis-european-research-council-award-101097676","Biodiversity, abrupt ecosystem shifts and restoration: understanding their links to sustain drylands under global change","UNIVERSIDAD DE ALICANTE","€2,499,351","Global change and desertification drivers, such as climate change and increased fire frequency, make drylands more prone to abrupt shifts that can lead to the emergence of degraded states unable to provide key ecosystem services and to sustain life. However, we still lack an in-depth understanding of the prevalence and triggers of these shifts, and of the identity of those ecosystem attributes and services that are most affected, across global drylands. These uncertainties arise largely from the",{"id":871,"funder":7,"programme":8,"title":872,"piName":10,"institution":361,"country":59,"year":13,"amount":873,"abstract":874},"cordis-european-research-council-award-101097475","Strain-Free All Heusler Alloy Junctions","€3,108,441","Spintronics is anticipated to replace current semiconductor-based memories and sensors based on fast-operating times (\u003C ns) and low power consumption (\u003CpJ per read\u002Fwrite operation). The spintronic devices typically consist of a magnetoresistive junction with a free ferromagnet\u002Foxide barrier or non-magnet\u002Fpinned ferromagnet trilayer and may suffer from edge-domain formation and leakage current through the barrier by further miniaturisation (\u003C10 nm in cell diameter). To avoid such obstacles, antif",{"id":876,"funder":7,"programme":8,"title":877,"piName":10,"institution":367,"country":368,"year":13,"amount":878,"abstract":879},"cordis-european-research-council-award-101097439","Women in the Nordic Enlightenment: Changing the narratives of early modern philosophy and uncovering women’s contribution to Scandinavian gender equality","€2,446,884","The Enlightenment attracts a lot of scholarly attention due to its relevance for the emergence of modern philosophical thought and the identity of present-day Europe. Yet, women’s contribution to the Enlightenment has been largely ignored. WHENCE will fill this research gap in an original and groundbreaking way by focusing on an hitherto overlooked geographical region, namely Europe’s North. By targeting the writings of Scandinavian women, WHENCE will provide results that describe the Nordic way",{"id":881,"funder":7,"programme":8,"title":882,"piName":10,"institution":883,"country":40,"year":13,"amount":884,"abstract":885},"cordis-european-research-council-award-101096525","The Causal Effect of Motherhood, Gender Norms, and Cash Transfers to Women on Intimate Partner Violence","UNIVERSITAT DE BARCELONA","€2,497,000","“A life free of violence is a basic human right” (WHO 2013). Yet one in three women in the EU has experienced physical and\u002For sexual violence since age 15, with the perpetrator often her (ex-)partner. Ending gender-based and domestic violence is one of society’s greatest challenges and a top priority of the European Commission as reflected in its Gender Equality Strategy 2020-25. The question is how.WomEmpower is an interdisciplinary study adopting a comprehensive ecological framework (Heise 199",{"id":887,"funder":7,"programme":8,"title":888,"piName":10,"institution":788,"country":368,"year":13,"amount":889,"abstract":890},"cordis-european-research-council-award-101098064","The ANAEROBic treasure trunk","€2,494,159","ANAEROB aims to generate a platform that enables linking of microbial ecology to biotechnology. This platform should be general and applicable to a very wide range of conditions and applications. Anaerobic processes are performed by a well-structured microbial community and have a great potential for upcycling organic wastes and industrial\u002Fagricultural residual resources to achieve circular bioeconomy. Upcycling of residual resources through production of materials, biochemicals and energy is a ",{"id":892,"funder":7,"programme":8,"title":893,"piName":10,"institution":894,"country":782,"year":13,"amount":895,"abstract":896},"cordis-european-research-council-award-101097240","The Orders and Borders of Global Inequality: Migration and Mobilities in Late Capitalism","UNIVERSITY COLLEGE CORK -  NATIONAL UNIVERSITY OF IRELAND, CORK","€2,491,015","MIGMOBS investigates how borders and hierarchies are maintained between “the West and the Rest”, even as those who are internationally mobile sometimes succeed in challenging the “birthright lottery” - i.e. that citizenship at birth most determines someone’s chances in life. It asks: How does changing categorisation of subordinate populations worldwide in terms of “migration”, “free movement”, and “minorities” relate to these in- and between- country inequalities? It echoes critical migration, m",{"id":898,"funder":7,"programme":8,"title":899,"piName":10,"institution":900,"country":59,"year":13,"amount":901,"abstract":902},"cordis-european-research-council-award-101098056","Giant-leaps during tumorigenesis: Dissecting saltatory evolution in cancer ‘in the making’","EUROPEAN MOLECULAR BIOLOGY LABORATORY","€3,428,458","Tumorigenesis is an evolutionary process driven by gradual mutation acquisition to confer selective advantages to somatic cells. DNA rearrangements are the most common cancer driver mutation, outnumbering base substitutions. Rearrangements amplify, disrupt and fuse genes or alter their gene regulation, ultimately driving adaptive changes to initiate cancer, metastasis and therapy resistance. Cancer genomics has revealed that most of these alterations arise as complex genomic rearrangements (CGRs",{"id":904,"funder":7,"programme":8,"title":905,"piName":10,"institution":906,"country":132,"year":13,"amount":907,"abstract":908},"cordis-european-research-council-award-101097891","Building models of, with and for sustainability transformations","STOCKHOLMS UNIVERSITET","€2,498,060","While the need for sustainability transformations is ubiquitous, understanding why and how they succeed or fail is limited. Explanations often focus on either agency-related or systemic factors. Understanding the complex dynamics of transformations, however, requires approaches that bridge perspectives, and recognize the interdependent personal, political, social and ecological dynamics at play. TRANSMOD addresses this gap through interdisciplinary analysis of transformative change in the contex",{"id":910,"funder":7,"programme":8,"title":911,"piName":10,"institution":160,"country":84,"year":13,"amount":912,"abstract":913},"cordis-european-research-council-award-101095722","Geometric Analysis and Surface Groups","€2,325,043","We propose to study links between  curves in flag manifolds, surfaces solutions of geometric partial differential equations in some affine symmetric spaces, and functions on the moduli space of curves. We will consider the relevant energy functions on the moduli spaces of those curves, or on the moduli space of Anosov representations for periodic data, in particular in the context of positivity.  Amongst our concrete ambitious goals are: obtain topological invariant through quantising Anosov def",{"id":915,"funder":7,"programme":8,"title":916,"piName":10,"institution":917,"country":918,"year":13,"amount":919,"abstract":920},"cordis-european-research-council-award-101095951","Program Intelligence, Declaratively and Symbolically","ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON","EL","€2,395,875","The automatic understanding of programs, in insightful, high-level terms, has long been a dream of computer science. The area of static program analysis has made significant progress in such understanding by algorithmically modeling all possible program behaviors. In this setting, declarative program analysis has recently demonstrated great success in capturing powerful algorithms efficiently and elegantly, in a form that bridges mathematical logic and intuitive human understanding.The PI’s rese",{"id":922,"funder":7,"programme":8,"title":923,"piName":10,"institution":781,"country":782,"year":13,"amount":924,"abstract":925},"cordis-european-research-council-award-101097213","Integration through rights in a European Society? A new theory on the role of law for integration within and beyond a fractured EU","€2,498,916","Among the many crises of the European Union (EU), the fracturing of its promise to integrate the emerging European society peacefully through law represents a fundamental one. At the time of writing, martial conflict and pressure through economic sanctions are once again relied upon to assuage conflict in the EUs neighbourhood, while the authority of EU law has been challenged by several Constitutional Courts, most recently by the Romanian and the Polish supreme courts in December and September ",{"id":927,"funder":7,"programme":8,"title":928,"piName":10,"institution":862,"country":132,"year":13,"amount":929,"abstract":930},"cordis-european-research-council-award-101096064","Unveiling the functional outcome of single nucleotide polymorphisms and variants in oligodendroglia in multiple sclerosis","€3,182,846","Multiple sclerosis (MS) is a neurological disease characterized by autoimmune attack targeting oligodendroglia (OLG) in the central nervous system (CNS), and in particular their myelin, which ensheaths neuronal axons. Genome-wide association studies (GWAS) have led to the identification of hundreds of single-nucleotide polymorphisms (SNPs) and variants that are associated with MS risk. Many of these are located near genes associated with immune cells, indicating a key role for these cells in MS.",{"id":932,"funder":7,"programme":8,"title":933,"piName":10,"institution":934,"country":40,"year":13,"amount":935,"abstract":936},"cordis-european-research-council-award-101097511","Carnivores in human settlements: a new and different way to address the Middle Palaeolithic record","FUNDACIO PRIVADA INSTITUT CATALA DE PALEOECOLOGIA HUMANA I EVOLUCIO SOCIAL","€2,454,563","Anthropogenic sites often emerge from overlapping actions and\u002For occupations that include disruptive processes. Consequently, the palimpsests that arise can have a disorderly appearance, which may complicate the interpretation of such sites. The problem is worsened when some agents, such as carnivore scavengers, act on the archaeological record, causing the remains to disappear and leaving no obvious signs of their passage. Such occurrences have important consequences for archaeological studies,",{"id":938,"funder":7,"programme":8,"title":939,"piName":10,"institution":556,"country":97,"year":13,"amount":940,"abstract":941},"cordis-european-research-council-award-101098168","Perovskite triple and quadruple junction solar cells","€2,999,926","Metal halide perovskite solar cells have advanced from an intriguing scientific discovery into a viable option for future renewable energy. Record single and tandem junction perovskite solar cells already provide power efficiencies close to 26% and 30%, respectively. The aim of this project is to achieve the next target in photovoltaic energy conversion by developing perovskite triple and quadruple junction solar cells towards efficiencies of 35% to 40% using cheap solution-processable materials",{"id":943,"funder":7,"programme":8,"title":944,"piName":10,"institution":138,"country":59,"year":13,"amount":104,"abstract":945},"cordis-european-research-council-award-101096243","Explaining Common Envelope Evolution and Dynamics in binary stellar systems","A thorough understanding of stellar evolution is key to nearly any branch of astrophysics. The majority of stars evolves in binary or multiple systems and interactions often occur between their components. Such dynamical interaction phases are pivotal for the fate of the system and its constituents, but they elude classical stellar modeling. Common-envelope phases, in which a compact companion spirals into the envelope of a giant primary star, are the glaring gaps in our knowledge and pose one o",{"id":947,"funder":7,"programme":8,"title":948,"piName":10,"institution":781,"country":782,"year":13,"amount":949,"abstract":950},"cordis-european-research-council-award-101095098","NANO-PERSONALITY: ENGINEERING AND MANIPULATING GREEN SOLVENTS BY NANO-BUBBLES (NIMBLE)","€2,461,515","Nano-bubbles exhibit several unique physical and mechanical characteristics, such as dramatically reduced buoyancy, extremely high surface area\u002Fvolume ratio, large zeta potentials, enhanced solubility of gas in water. These properties render them good candidates for several commercial applications, such as fine-particle flotation, wastewater treatment, and in food and agricultural industries. A most important challenge lies in establishing facile and easily-controlled methods to promote nano-bub",{"id":952,"funder":7,"programme":8,"title":953,"piName":10,"institution":292,"country":26,"year":13,"amount":954,"abstract":955},"cordis-european-research-council-award-101097302","The anthropology of the future: An art world perspective","€2,499,911","The future has been neglected as an object of anthropological study, even though our complex social, ecological and now, with COVID-19, biopolitical crises demand novel imaginations of the yet-to-come. Moreover, anthropologists have urged the decolonisation of existing studies of the future that are often based in the global norths concerns. ANTHROFUTURE shifts the focus of the anthropology of the future to the pandemic-induced acceleration of the future into the present. The project identifies ",{"id":957,"funder":7,"programme":8,"title":958,"piName":10,"institution":959,"country":960,"year":13,"amount":961,"abstract":962},"cordis-european-research-council-award-101098001","Automated, miniaturized and accelerated drug discovery:  AMADEUS","UNIVERZITA PALACKEHO V OLOMOUCI","CZ","€3,409,401","The mantra ‘Automation + Miniaturization = Acceleration’ is successfully applied in many research areas and technologies, but not in synthetic chemistry, which is largely believed to be not automatable. However, with the potential to accelerate discoveries while flattening costs, increase safety, streamline data generation, enhance reproducibility, and lower the environmental footprint, automation and miniaturization are two promising approaches to synthesis and are worthwhile to invest in.  I w",{"id":964,"funder":7,"programme":8,"title":965,"piName":10,"institution":722,"country":84,"year":13,"amount":966,"abstract":967},"cordis-european-research-council-award-101095959","Strong light-matter coupled ultra-fast and non-linear quantum semiconductor devices","€2,496,206","This project will combine for the first time strong light-matter coupling in quantum-confined electronic systems with the optical and electronic non-linearities of semiconductor heterostructures: we will develop device concepts with unique ultra-fast, non-linear and quantum functionalities. The key ingredient is an unconventional use of the strong light-matter coupling regime (SCR), a fascinating concept that is recently transitioning from basic physics to quantum devices.We will first address f",{"id":969,"funder":7,"programme":8,"title":970,"piName":10,"institution":367,"country":368,"year":13,"amount":104,"abstract":971},"cordis-european-research-council-award-101097979","Signaling decoded in ENhanCEr states – a molecular basis for plasticity in development and differentiation","Transcription is regulated by transcription factors (TFs) bound at enhancer elements located long-distances from the genes they regulate. How does this account for dynamic responses to the environment via signaling? Canonical views invoke signal induced changes in TF expression\u002Fmodification or cofactor localization, but here we suggest that TF occupancy could be present before and after the signal, establishing competence, ensuring plasticity and blocking premature commitment. For ERK signaling,",{"id":973,"funder":7,"programme":8,"title":974,"piName":10,"institution":975,"country":132,"year":13,"amount":976,"abstract":977},"cordis-european-research-council-award-101093345","Breaking the Inequality-Crime Cycle: Biases in Police Decisions, 'What Works' in Prison, and Firm Demand for Workers with Criminal Records","GOETEBORGS UNIVERSITET","€2,293,407","Economic inequality across the population implies vastly unequal opportunities in many dimensions that can impact an individuals chance of entering the justice system. One such channel via which this can occur  even holding criminal behavior constant  is unequal treatment by agents of the justice system (e.g. police). The consequences of such partiality is not trivial: once in the system, it is hard to get out. And to the extent that convictions and sanctions result in worse outcomes (e.g. emplo",{"id":979,"funder":7,"programme":8,"title":980,"piName":10,"institution":981,"country":40,"year":13,"amount":982,"abstract":983},"cordis-european-research-council-award-101097693","Coherent control of spin chains in graphene nanostructures","ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN NANOCIENCIAS CIC NANOGUNE","€2,988,750","Elementary nuclear and electronic spins are called to be key components in the second quantum revolution. Their atomic-scale integration into scalable platforms with tunable interactions is a demand that I will address in CONSPIRA by synthetizing graphene architectures with interacting spin chains, using customized on-surface reactions of organic precursors, and by controlling their quantum state through microwave spectroscopies.                 I envision the formation of collective magnetic st",{"id":985,"funder":7,"programme":8,"title":986,"piName":10,"institution":987,"country":33,"year":13,"amount":988,"abstract":989},"cordis-european-research-council-award-101096539","Bioarchaeology of Orchards and Sustainable Terroir in the Arid Near East – Trends in Ecology and Evolution","UNIVERSITY OF HAIFA","€3,496,176","Engaging with the myriad challenges linked to global warming and the unchecked expansion of drylands, the project seeks to develop models for implementing past agricultural know-how in modern socioeconomic contexts. Our novel methodology fuses cutting-edge interdisciplinary scientific approaches from the humanities and natural sciences with an inclusive citizen science framework to examine the ecological history and cultivar diversity of relic ‘heritage horticulture’ in four distinct arid region",{"id":991,"funder":7,"programme":8,"title":992,"piName":10,"institution":993,"country":765,"year":13,"amount":994,"abstract":995},"cordis-european-research-council-award-101096606","Architecture, Colonialism and Labour.  The role and legacy of mass labour in the design, planning and construction of Public Works in former African territories under Portuguese colonial rule","ASSOCIACAO ISCTE CONHECIMENTO E INOVACAO - CENTRO DE VALORIZACAO E TRANSFERENCIA DE TECNOLOGIAS","€2,499,996","The discipline of architecture, when dealing with Public Works associated with colonialism and territorial occupation, still focuses on the analysis of the constitution of the design teams, of the colonial Public Works offices, of the architects and engineers themselves. This focus on the designing elite misses a critical input to these Public Works, namely the Labour force responsible for realising these structures. As such, critical questions about the labour force engaged in the spatializatio",{"id":997,"funder":7,"programme":8,"title":998,"piName":10,"institution":999,"country":59,"year":13,"amount":1000,"abstract":1001},"cordis-european-research-council-award-101096046","A novel approach to improved navigation performance through memory triggering maps","RUHR-UNIVERSITAET BOCHUM","€2,498,390","As people become more mobile, navigation systems in cars or mobile phones are playing an increasingly important role in spatial orientation and navigation. However, the cognitive map created in the user's mind when using such navigation devices is much more fragmented, incomplete and inaccurate, compared to the mental model of space created when reading a conventional printed map. As users become more dependent on digital devices that reduce orientation skills, there is an urgent need to develop",{"id":1003,"funder":7,"programme":8,"title":1004,"piName":10,"institution":321,"country":59,"year":13,"amount":1005,"abstract":1006},"cordis-european-research-council-award-101096251","Control for Deep and Federated Learning","€2,499,224","Machine Learning (ML) is forging a new era in Applied Mathematics (AM), leading to innovative and powerful methods. But the need for theoretical guarantees generates challenging, fundamental, deep mathematical questions. This great challenge can be addressed from the perspective of other, more mature areas of AM. CoDeFeL seeks to do so from the rich interface between Control Theory (CT) and ML, contributing to the analytical foundations of ML methods, significantly enlarging, and updating the ra",{"id":1008,"funder":7,"programme":8,"title":1009,"piName":10,"institution":1010,"country":132,"year":13,"amount":104,"abstract":1011},"cordis-european-research-council-award-101096650","Sustainable light-emitting devices through control of dynamic doping","UMEA UNIVERSITET","Artificial illumination is fundamental and ubiquitous in modern society, and the cuArtificial illumination is fundamental and ubiquitous in modern society, and the current large-scale commercialization of more efficient and practical technologies, in the form of LEDs and OLEDs, is therefore important. This development is not only resulting in improved luminaires and displays, but also paving the way for a wide range of applications in, e.g., medtech, security, and communication. However, a growi",{"id":1013,"funder":7,"programme":8,"title":1014,"piName":10,"institution":361,"country":59,"year":13,"amount":1015,"abstract":1016},"cordis-european-research-council-award-101098178","Dissecting the cancer epigenome –  fundamental lessons from developmental biology","€2,487,500","DNA methylation is a tightly controlled mechanism that is essential for normal development and genome regulation. Although maintained in a highly static pattern across healthy tissues, DNA methylation is globally reprogrammed in nearly all malignant cancers, including gains at thousands of gene promoters and global loss across large domains. Substantial work from our group to characterize multiple primary tumor cohorts, transgenic animal models, and cancer cell lines finds that current experimen",{"id":1018,"funder":7,"programme":8,"title":1019,"piName":10,"institution":422,"country":97,"year":13,"amount":480,"abstract":1020},"cordis-european-research-council-award-101098079","EuroFlash: exploring the origins of fast radio bursts using a network of European radio telescopes","Fast radio bursts (FRBs) present astronomers with a compelling mystery: what is creating these brilliant but ephemeral flashes that travel billions of lightyears before reaching Earth? Whatever is producing the FRBs, it requires an extreme energy density and the conditions for `laser-like’ coherent radio emission to be generated. While recent discoveries show that magnetars are a leading contender, the heterogeneous properties of the known FRB sample strongly suggest that there are multiple FRB ",{"id":1022,"funder":7,"programme":8,"title":1023,"piName":10,"institution":1024,"country":26,"year":13,"amount":1025,"abstract":1026},"cordis-european-research-council-award-101097326","Adsorbate Motors: Tricking Microscopic Reversibility on Surfaces","UNIVERSITAET GRAZ","€2,499,909","AMOS represents a ground-breaking approach to achieve uni-directional motion on well-defined surfaces, realize cooperative motor activity, control flow processes and transport cargo at the atomic scale. It is based on molecule-surface motors that overcome microscopic reversibility via controlled potential energy surface modulation with high potential impact in various fields. Light will be used to excite molecular motion, offering great versatility. Hence, the stimulus is given remotely to many ",{"id":1028,"funder":7,"programme":8,"title":1029,"piName":10,"institution":1030,"country":59,"year":13,"amount":1031,"abstract":1032},"cordis-european-research-council-award-101098020","Biodiversity change across time and space in the Anthropocene: Leveraging metacommunity modelling, land-use change, and open data to achieve deeper understanding","MARTIN-LUTHER-UNIVERSITAT HALLE-WITTENBERG","€2,439,071","Despite connections between metacommunity level processes that maintain biodiversity and anthropogenic pressures that erode those processes, these have not been well integrated. I propose a multifaceted approach that(1) builds on metacommunity theory to develop expectations for the influence of anthropogenic drivers on scale-explicit biodiversity change;(2) uses this theory to develop an analytical pipeline to disentangle local and landscape factors driving this change;(3) use the derived result",{"id":1034,"funder":7,"programme":8,"title":1035,"piName":10,"institution":1036,"country":40,"year":13,"amount":1037,"abstract":1038},"cordis-european-research-council-award-101142133","Valence asymmetries: the positive, the negative, \u2028the good and the bad in language, mind and morality","UNIVERSIDAD POMPEU FABRA","€2,096,875","An asymmetric behavior between the positive and the negative has been evidenced in psychology, for information processing, attention, recognition and decision making, in philosophy, for judgments about morality and intentionality, and in linguistics, for a range of lexical, syntactic, semantic and pragmatic phenomena. Negative information grabs our attention, we process it more carefully, we recall it with greater precision. We easily blame others for the negative side-effects of their actions, ",{"id":1040,"funder":7,"programme":8,"title":1041,"piName":10,"institution":1042,"country":59,"year":13,"amount":1043,"abstract":1044},"cordis-european-research-council-award-101098206","Exploring inflammasome activation and targeted inhibition","UNIVERSITATSKLINIKUM BONN","€2,155,047","Inflammasomes are cytosolic multi-protein complexes that form in response to a wide range of pathogens, tissue damage, and other harmful stimuli. Members of the family of NOD-like receptors (NLRs) sense these pathogen and danger associated molecular patterns, triggering innate immune responses. NLRP3 is a well-studied NLR whose activation by a broad spectrum of stimuli leads to inflammasome formation and pyroptosis. Yet, the mechanisms inducing NLRP3 activation and the way how antagonistic small",{"id":1046,"funder":7,"programme":8,"title":1047,"piName":10,"institution":1048,"country":66,"year":13,"amount":1049,"abstract":1050},"cordis-european-research-council-award-101098074","CHARTING THE TOKEN OF TIME: YAP\u002FTAZ TRANSCRIPTIONAL REGULATORS AT THE ROOTS OF AGING","UNIVERSITA DEGLI STUDI DI PADOVA","€2,811,871","A major challenge in aging research is to distinguish which age-related alterations play a driving role and their interconnections. Aging ultimately implies dysregulated transcription; yet, the identity of signaling cascades and transcription factors that control youthfulness and aging in adult tissues remains poorly understood. Aging also entails maladaptive changes in how cells communicate with each other and their surrounding extracellular matrix (ECM). Senolytics approaches have revealed the",{"id":1052,"funder":7,"programme":8,"title":1053,"piName":10,"institution":1054,"country":84,"year":13,"amount":1055,"abstract":1056},"cordis-european-research-council-award-101097091","STAGE: From Stage to Data, the Digital Turn of  Contemporary Performing Arts Historiography","UNIVERSITE RENNES II","€2,487,306","Digital sources are one of the most significant challenges facing performing arts historiography. At the intersection of history, epistemology, and digital humanities, STAGEs key goal is to move performing arts studies into a digital context to establish a new historiography of mise en scne and their creative processes in Europe since WWII. It proposes a groundbreaking theoretical and methodological framework merging culture analytics, actor-network theory, data modeling, and computer vision to ",{"id":1058,"funder":7,"programme":8,"title":1059,"piName":10,"institution":1060,"country":40,"year":13,"amount":104,"abstract":1061},"cordis-european-research-council-award-101141466","MXENES AS THERMAL CATALYSTS. EXPLOITING THE IDEAL PROPERTIES OF CHAMELEONIC MATERIALS","UNIVERSITAT POLITECNICA DE VALENCIA","MXenes were discovered in 2011 and, since then, have attracted attention as electro- and photocatalysts. In contrast, the ideal properties of MXenes as thermal catalysts remain almost unexplored, there being a very limited number of studies. The main reasons for this apparent lack of interest are: i) the shift in catalysis from heat as energy to overcome activation barriers to green electricity or sunlight, ii) the limited number of commercial MXenes and iii) the relative novelty of these materi",{"id":1063,"funder":7,"programme":8,"title":1064,"piName":10,"institution":206,"country":33,"year":13,"amount":1065,"abstract":1066},"cordis-european-research-council-award-101097995","Melanosomes as cancer immune modulators: a novel paradigm in melanoma immunity","€2,515,625","Despite remarkable progress in treating melanoma, the most lethal of human skin cancers, 50% of patients are treatment-resistant, with most experiencing disease recurrence. Our recent unpublished clinical and experimental findings uncover new, yet to be explored, melanosome contributions to cancer immunity unique to melanoma. Melanoma retains, for mostly unknown reasons, the ability of its origin to produce melanosomes, lineage-specific large extracellular vesicles (EVs) containing melanin. Surp",{"id":1068,"funder":7,"programme":8,"title":1069,"piName":10,"institution":630,"country":84,"year":13,"amount":1070,"abstract":1071},"cordis-european-research-council-award-101098319","Harmony within society","€1,597,750","Our living together is confronted with new challenges, as our modern world widens our public sphere and smushes together groups with different value systems. In turn, agents take refuge in safe spaces, where their behavior and speech are protected from bad inferences. This ambitious project aims at proposing a unified framework- building on the role of the dissemination of personal information- to study social interactions, and at fostering the academic community’s engagement on the study of the",{"id":1073,"funder":7,"programme":8,"title":1074,"piName":10,"institution":505,"country":173,"year":13,"amount":1075,"abstract":1076},"cordis-european-research-council-award-101098266","Social networks and natural selection in changing societies","€2,499,971","Social interactions can improve support, resources and protection, but can also increase disease, stress and conflict. Consequently, for group-living species inc. humans, traits as diverse as personality, residence patterns, family-living and disease resistance all evolve in response to pros and cons of sociality. However, the direct links between sociality, health, fitness outcomes and ultimately natural selection are not well-known. KinSocieties reveals, for the first time, the benefits and co",{"id":1078,"funder":7,"programme":8,"title":1079,"piName":10,"institution":722,"country":84,"year":13,"amount":954,"abstract":1080},"cordis-european-research-council-award-101097167","The evolution of cis and trans-regulators in eukaryotes","Gene regulation plays an essential role in shaping species differences and modulating phenotypes across development and environmental conditions. It essentially works through the recruitment of trans-acting intermediates to cis-acting DNA sequences affecting the expression of the nearby gene. While gene expression regulation is central in molecular, cellular, developmental, and system biology, its detailed mechanisms have relatively little been incorporated into modern evolutionary theory. I pre",{"id":1082,"funder":7,"programme":8,"title":1083,"piName":10,"institution":862,"country":132,"year":13,"amount":1084,"abstract":1085},"cordis-european-research-council-award-101097871","Somatic mutations in vascular-wall function and age-associated disease","€2,532,795","Already in 1973, Benditt and Benditt found that the atherosclerotic plaque was clonal and proposed that it was a neoplasm of vascular smooth muscle cells (VSMC). Recent technical advances have made it possible to analyze somatic mutations in human tissues and show that somatic cells accumulate thousands of mutations during development and aging. While most of the mutations are harmless, some either contribute to disease and aging or are directly disease-causative, as in the formation of tumors i",{"id":1087,"funder":7,"programme":8,"title":1088,"piName":10,"institution":788,"country":368,"year":13,"amount":1089,"abstract":1090},"cordis-european-research-council-award-101097215","Illuminating Charge Transport in Feldspar to Measure Rates of Earth Surface Processes","€2,998,010","LUMIN will enable unprecedented quantitative measurements of rates of Earth surface processes, through a new understanding of the charge transfer that records these rates in natural minerals. Earth surface processes sculpt landscapes, disperse nutrients and affect climates and ecosystems; knowledge of the rates of these processes is fundamental to understanding and predicting landscape evolution. Quantifying such rates has proven very challenging over 0.0001-100 m spatial and 10-100,000 year tem",{"id":1092,"funder":7,"programme":8,"title":1093,"piName":10,"institution":1094,"country":40,"year":13,"amount":1095,"abstract":1096},"cordis-european-research-council-award-101097905","INVESTIGATION OF THE ENANTIOMERIC IMBALANCE IN THE SOLAR SYSTEM THROUGH ULTRAVIOLET SPECTROPOLARIMETRY","UNIVERSIDAD COMPLUTENSE DE MADRID","€2,463,698","Amino acids and the reference nucleobases for RNA and DNA can be formed in space ice under high energy, vacuum ultraviolet (VUV) irradiation. This statement is based on twenty years of laboratory research and has profound implications in the understanding of the emergence of life in the Cosmos, the universality of the processes involved and the compatibility of life forms across the Universe. However, this laboratory work still needs to be confronted with actual, on-field measurements. Promising",{"id":1098,"funder":7,"programme":8,"title":1099,"piName":10,"institution":1100,"country":960,"year":13,"amount":1101,"abstract":1102},"cordis-european-research-council-award-101097822","Federated foundational models for embodied perception","CESKE VYSOKE UCENI TECHNICKE V PRAZE","€2,499,825","Computer vision is beginning to see a paradigm shift with large-scale foundational models that demonstrate impressive results on a wide range of recognition tasks. While achieving impressive results, these models learn only static 2D image representations based on observed correlations between still images and natural language. However, our world is three-dimensional, full of dynamic events and causal interactions. We argue that the next scientific challenge is to invent foundational models for ",{"id":1104,"funder":7,"programme":8,"title":1105,"piName":10,"institution":1106,"country":84,"year":13,"amount":1107,"abstract":1108},"cordis-european-research-council-award-101142600","New physics in parity violation. From the Thomson limit to the energy frontier","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","€3,202,849","The theory of elementary particle physics, the Standard Model (SM), provides a successful description of the basic constituents of matter and the forces acting between them. However, it explains only about 15 % of the total mass in the universe, not accounting for the dark matter postulated in the face of astrophysical and cosmological data. The study of the universe at large shows that our theory of the smallest entities of Nature must be extended.In the absence of a direct observation of new p",{"id":1110,"funder":7,"programme":8,"title":1111,"piName":10,"institution":1112,"country":84,"year":13,"amount":1113,"abstract":1114},"cordis-european-research-council-award-101141721","Empowering Neural Rendering Methods with Physically-Based Capabilities","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","€2,488,029","While long restricted to an elite of expert digital artists, 3D content creation has recently been greatly simplified by deep learning. Neural representations of 3D objects have revolutionized real-world capture from photos, while generative models are starting to enable 3D object synthesis from text prompts. These methods use differentiable neural rendering that allows efficient optimization of the powerful and expressive ``soft'' neural representations, but ignores physically-based principles,",200,{"programme":8,"total":1117,"withPiName":1118,"firstYear":1119,"lastYear":1120,"countryCount":1121,"perYear":1122,"topInstitutions":1179,"topCountries":1250},4756,450,2008,2027,46,[1123,1125,1128,1131,1134,1137,1140,1143,1146,1149,1151,1154,1157,1160,1163,1166,1169,1171,1174,1177],{"year":1119,"count":1124},47,{"year":1126,"count":1127},2009,232,{"year":1129,"count":1130},2010,248,{"year":1132,"count":1133},2011,276,{"year":1135,"count":1136},2012,293,{"year":1138,"count":1139},2013,344,{"year":1141,"count":1142},2014,359,{"year":1144,"count":1145},2015,138,{"year":1147,"count":1148},2016,299,{"year":1150,"count":1127},2017,{"year":1152,"count":1153},2018,376,{"year":1155,"count":1156},2019,241,{"year":1158,"count":1159},2020,137,{"year":1161,"count":1162},2021,228,{"year":1164,"count":1165},2022,322,{"year":1167,"count":1168},2023,252,{"year":13,"count":1170},243,{"year":1172,"count":1173},2025,222,{"year":1175,"count":1176},2026,264,{"year":1120,"count":1178},3,[1180,1183,1186,1189,1192,1195,1198,1201,1204,1207,1210,1213,1216,1219,1222,1225,1228,1231,1233,1236,1238,1240,1242,1245,1247],{"name":1181,"count":1182},"Centre National de la Recherche Scientifique CNRS",206,{"name":1184,"count":1185},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",133,{"name":1187,"count":1188},"University of Oxford",128,{"name":1190,"count":1191},"University of Cambridge",124,{"name":1193,"count":1194},"Eidgenoessische Technische Hochschule Zuerich",84,{"name":1196,"count":1197},"Weizmann Institute of Science",74,{"name":1199,"count":1200},"École Polytechnique Fédérale de Lausanne",72,{"name":1202,"count":1203},"University College London",69,{"name":1205,"count":1206},"Ludwig-Maximilians-Universitaet Muenchen",59,{"name":1208,"count":1209},"The Hebrew University of Jerusalem",57,{"name":1211,"count":1212},"Katholieke Universiteit Leuven",52,{"name":1214,"count":1215},"University of Bristol",49,{"name":1217,"count":1218},"University of Edinburgh",48,{"name":1220,"count":1221},"Kobenhavns Universitet",40,{"name":1223,"count":1224},"Universiteit van Amsterdam",39,{"name":1226,"count":1227},"Institut National de la Sante Et de la Recherche Medicale",38,{"name":1229,"count":1230},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",35,{"name":1232,"count":1230},"Tel Aviv University",{"name":1234,"count":1235},"Imperial College of Science Technology and Medicine",33,{"name":1237,"count":1235},"Technische Universitaet Muenchen",{"name":1239,"count":1235},"Universitat Wien",{"name":1241,"count":1235},"University of Manchester",{"name":1243,"count":1244},"Helsingin Yliopisto",32,{"name":1246,"count":1244},"Karolinska Institutet",{"name":1248,"count":1249},"Technische Universiteit Delft",30,[1251,1253,1256,1258,1260,1263,1265,1267,1269,1271,1273,1274,1276,1279,1281,1283,1285,1286,1288,1290,1293,1295,1297,1298,1301],{"name":59,"count":1252},802,{"name":1254,"count":1255},"UK",778,{"name":84,"count":1257},581,{"name":97,"count":1259},390,{"name":1261,"count":1262},"CH",310,{"name":66,"count":1264},302,{"name":40,"count":1266},269,{"name":33,"count":1268},202,{"name":132,"count":1270},183,{"name":26,"count":1272},153,{"name":47,"count":1272},{"name":368,"count":1275},107,{"name":1277,"count":1278},"GB",78,{"name":173,"count":1280},76,{"name":12,"count":1282},65,{"name":782,"count":1284},42,{"name":765,"count":1221},{"name":260,"count":1287},25,{"name":918,"count":1289},24,{"name":1291,"count":1292},"US",20,{"name":349,"count":1294},18,{"name":960,"count":1296},15,{"name":758,"count":1296},{"name":1299,"count":1300},"CN",9,{"name":1302,"count":1303},"EE",8]