[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-advanced-grant-2025":3,"awarded-stats-erc-advanced-grant":1119},{"awarded":4,"total":1118},[5,16,21,28,35,42,49,55,62,68,74,81,87,93,100,106,112,118,124,130,136,143,149,154,160,166,172,179,185,192,198,204,210,215,221,227,233,238,243,248,254,260,266,270,276,282,288,295,300,305,311,317,323,329,335,340,346,352,358,363,367,373,380,385,391,396,402,408,414,420,425,430,435,441,447,452,459,465,470,476,482,488,494,500,506,512,518,524,528,532,538,543,548,554,560,564,569,575,581,587,593,599,604,609,615,621,628,634,641,646,651,657,662,667,672,678,684,690,695,700,705,710,715,721,726,731,736,742,747,752,757,761,767,772,777,782,787,791,796,801,807,811,816,820,824,830,836,841,847,852,856,862,868,873,879,883,888,893,898,904,908,913,919,925,931,936,941,945,951,957,962,966,970,976,981,986,992,998,1003,1008,1013,1018,1023,1028,1033,1038,1044,1050,1055,1061,1066,1071,1076,1082,1087,1091,1096,1102,1108,1114],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-european-research-council-award-advanced-grant-glow-101096017-","European Research Council","ERC Advanced Grant","Modality-Agnostic Decoding of Vision and Language from fMRI","Mitja Nikolaus","Centre National de la Recherche Scientifique","FR",2025,null,"Humans perform tasks involving the manipulation of inputs regardless of how these signals are perceived by the brain, thanks to representations that are invariant to the stimulus modality. In this paper, we present modality-agnostic decoders that leverage such modality-invariant representations to predict which stimulus a subject is seeing, irrespective of the modality in which the stimulus is presented. Training these modality-agnostic decoders is made possible thanks to our new large-scale fMR",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":11,"country":12,"year":13,"amount":14,"abstract":20},"openalex-european-research-council-award-erc-adg-xxl-nmr-101097926","Subunit-specific isotope labelling of heteromeric complexes using cell-free protein expression: application to the 760 kDa ClpXP molecular machine","Astrid Audibert","-labelling of the alanine and methionine in ClpXP allowed acquisition of high quality 2D solution NMR spectra, the characterization of the oligomeric size using diffusion-ordered NMR spectroscopy, and observation of structural rearrangements induced by nucleotide binding.",{"id":22,"funder":7,"programme":8,"title":23,"piName":24,"institution":25,"country":26,"year":13,"amount":14,"abstract":27},"openalex-european-research-council-award-adg-n-101019659-firststeps-pi-k-harvati-","The Human Remains From the \u003Cscp>MIS\u003C\u002Fscp> 6 Site of Grotta Del Poggio (Cilento, Southern Italy): A Taxonomic and Chronological Reassessment","Erica Piccirilli","University of Bologna","IT","OBJECTIVES: Grotta del Poggio is a key site for exploring the Middle Paleolithic in southern Italy, as it contains a pivotal anthropogenic deposit, mainly attributed to MIS 6, while in the Metal Ages, the cavity was used as a burial place. Excavations in the cave's deposit led to the discovery of a human molar and a human talus. A preliminary morphological evaluation of the talus concluded that it belonged to Homo sapiens. Conversely, the molar exhibited Neanderthal-like morphology. Here, we per",{"id":29,"funder":7,"programme":8,"title":30,"piName":31,"institution":32,"country":33,"year":13,"amount":14,"abstract":34},"openalex-european-research-council-award-erc-2017-adg-789384","GM-CSF and specific type 2 cytokines induce CD103+ and CD301b+ cell states in cDC1s and cDC2s","Lukas Amon","VIB-UGent Center for Inflammation Research","BE","cDC2s exhibit enhanced T cell priming capacities and distinct cytokine expression profiles upon GM-CSF exposure. In vivo, DC-intrinsic GM-CSF sensing is dispensable for acquiring CD103 and CD301b expression with the notable exception of lung DCs, while specific type 2 cytokines induce CD103 and CD301b ex vivo. These findings identify GM-CSF and specific type 2 cytokines as central regulators of cDC1 and cDC2 effector differentiation and establish CD301b as a marker of a cytokine-driven cDC2 stat",{"id":36,"funder":7,"programme":8,"title":37,"piName":38,"institution":39,"country":40,"year":13,"amount":14,"abstract":41},"openalex-european-research-council-award-adg-2016-741888-csi-fun","Fecal Detection of Calprotectin Subunits Links Inflammatory Bowel Disease Activity With Chronicity of Intestinal Inflammation","Almina Jukic","Innsbruck Medical University","AT","BACKGROUND & AIMS: Quantification of the human S100A8\u002FS100A9 tetrameric protein complex in stool, referred to as fecal calprotectin, is an extensively validated biomarker supporting the diagnosis and management of gastrointestinal diseases. Here, we studied the quaternary protein structures (termed configuration) of S100A8 and S100A9 and their biological function in inflammatory bowel diseases (IBD). METHODS: We dissected fecal S100A8 and S100A9 configurations in patients with IBD by size-exclus",{"id":43,"funder":7,"programme":8,"title":44,"piName":45,"institution":46,"country":47,"year":13,"amount":14,"abstract":48},"openalex-european-research-council-award-101020503-evowild-erc-2020-adg","Unmeasured prior viability selection resolves the paradox of stasis for body size in wild Soay sheep","Elizabeth A. Mittell","University of Edinburgh","GB","The estimation of natural selection is used to understand ecological and evolutionary processes in wild populations and is often used to predict change. However, the direct application of quantitative genetic methods, originally developed in animal breeding, has been less successful in the wild; in particular, predictions of evolutionary change are often made that are not observed. This misprediction, known as the \"paradox of stasis,\" can arise due to bias in estimates of selection via nonrandom",{"id":50,"funder":7,"programme":8,"title":51,"piName":52,"institution":53,"country":47,"year":13,"amount":14,"abstract":54},"openalex-european-research-council-award-erc-adg-835002-u2014gems","Generating models of attentional cueing and inhibition of return with genetic programming","Laura Bartlett","London School of Economics and Political Science","The cueing task is a robust experimental paradigm for investigating attention. A centrally presented valid cue, correctly indicating the location of an upcoming target stimulus, leads to quicker responses than an invalid cue. A feature of this paradigm is that increasing the delay between a peripheral cue and a target reverses this effect, where responses become slower for a valid cue, a phenomenon termed inhibition of return (IOR). Using GEMS, a system that utilises genetic programming techniqu",{"id":56,"funder":7,"programme":8,"title":57,"piName":58,"institution":59,"country":60,"year":13,"amount":14,"abstract":61},"openalex-european-research-council-award-erc-2021-adg-clockrisk-101053225","Sex- and Ethnic Differences in the Cross-sectional Association Between Sleep Regularity and Obesity Among US Adults, NHANES 2011-2014","Eva Schernhammer","Brigham and Women's Hospital","US","\u003C 0.001). Similar inverse associations were observed for all other obesity measures. In conclusion, sleep regularity, measured by the SRI, was inversely associated with BMI and any other obesity measures. The observed disparities suggest sleep regularity may contribute differentially to obesity risk by sex and race\u002Fethnicity.",{"id":63,"funder":7,"programme":8,"title":64,"piName":65,"institution":66,"country":67,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-advanced-grant-no-882971-geoscape-","Partitioning Complete Geometric Graphs on Dense Point Sets into Plane Subgraphs","Adrian Dumitrescu","University of Bechar","DZ",{"id":69,"funder":7,"programme":8,"title":70,"piName":71,"institution":72,"country":12,"year":13,"amount":14,"abstract":73},"openalex-european-research-council-award-nerphys-erc-adg-101141721","Editable Physically-based Reflections in Raytraced Gaussian Radiance Fields","Yohan Poirier‐Ginter","Institut national de recherche en sciences et technologies du numérique","Radiance fields such as 3D Gaussian Splatting allow real-time rendering of scenes captured from photos. They also reconstruct most specular reflections with high visual quality, but typically model them with “fake” reflected geometry, using primitives behind the reflector. Our goal is to correctly reconstruct the reflector and the reflected objects such as to make specular reflections editable; we present a proof of concept which exploits promising learning-based methods to extract diffuse and s",{"id":75,"funder":7,"programme":8,"title":76,"piName":77,"institution":78,"country":79,"year":13,"amount":14,"abstract":80},"openalex-european-research-council-award-erc-2021-adg-320892","Structural dynamics of DNA mimic foldamers","Manuel Loos","Ludwig-Maximilians-Universität München","DE","H NMR, UV-vis absorption and circular dichroism spectroscopies. Measurements revealed that the foldamer helices are stable over a broad range of temperature, pH and salt conditions in aqueous solutions, but that they nevertheless undergo structural changes when conditions are modified. An assay was developed to quantitatively assess foldamer helix stability through the measurement of the rate of interconversion between right-handed and left-handed diastereomeric conformers. Unexpectedly, suppres",{"id":82,"funder":7,"programme":8,"title":83,"piName":14,"institution":84,"country":79,"year":13,"amount":85,"abstract":86},"cordis-european-research-council-award-101142285","Advancing orbitronics by pushing electron orbital angular momentum to terahertz speed","FREIE UNIVERSITAET BERLIN","€2,494,296","The spin angular momentum (S) of the electron has significantly extended conventional electronics, which relies on the electron charge (C), by new, so-called spintronic functionalities. Examples include magnetization switching, the transport of S and its detection, even down to femtosecond time scales. To boost the efficiency of spintronics, the so far neglected yet equally fascinating and important orbital angular momentum (L) of electrons is considered to be a powerful pathway. Orbitronic phen",{"id":88,"funder":7,"programme":8,"title":89,"piName":14,"institution":90,"country":79,"year":13,"amount":91,"abstract":92},"cordis-european-research-council-award-101141247","The Fragility, Instability, Ambiguity, and Self-Reflexivity of Images in Roman Art","CHRISTIAN-ALBRECHTS-UNIVERSITAET  ZU KIEL","€2,500,000","FRAGILE IMAGES fundamentally challenges the dominant notion of images as powerful actors. It moves away from the focus on the affective, persuasive, performative, and immersive image and instead focuses on its fragility, instability, ambiguity, and self-reflexivity. This radically new approach brings together a Visual Studies perspective and a cultural-historical approach and applies them to Roman imagery from the 2nd century BC to the 4th century AD. It has three main objectives:1) A systematic",{"id":94,"funder":7,"programme":8,"title":95,"piName":14,"institution":96,"country":97,"year":13,"amount":98,"abstract":99},"cordis-european-research-council-award-101141671","The Geopolitics of Cloud Computing: How State-Firm Interactions Shape the Geography of Computation to Produce Digital Sovereignty and Dependence","AALTO KORKEAKOULUSAATIO SR","FI","€2,499,458","Today’s digital superpowers, the United States and China, exploit other countries’ reliance on their digital infrastructures for foreign policy and national security advantage. Governments in Europe, Asia, and elsewhere try to navigate this great power competition to retain “digital sovereignty”. A pivotal moment in these technology geopolitics is the ongoing “shift to cloud”. Instead of data being stored and processed on users’ own devices and on servers situated at organizations’ own premises,",{"id":101,"funder":7,"programme":8,"title":102,"piName":14,"institution":103,"country":12,"year":13,"amount":104,"abstract":105},"cordis-european-research-council-award-101142705","Why do infants learn language so fast? A reverse engineering approach","ECOLE DES HAUTES ETUDES EN SCIENCES SOCIALES","€2,494,625","How do infants learn their first language(s)? The popular yet controversial 'statistical learning hypothesis' posits that they learn by gradually collecting statistics over their language inputs. This is strickingly similar to how current AI's Large Language Models (LLMs) learn and shows that simple statistical mechanisms may be sufficient to attain adult-like language competence. But does it? Estimates of language inputs to children show that by age 3, they have received 2 or 3 orders of magnit",{"id":107,"funder":7,"programme":8,"title":108,"piName":14,"institution":109,"country":110,"year":13,"amount":91,"abstract":111},"cordis-european-research-council-award-101140427","Aligning Brain Rhythms: Understanding the mechanisms of cortical tracking of speech to improve language functions with real time closed-loop neurofeedback","BCBL BASQUE CENTER ON COGNITION BRAIN AND LANGUAGE","ES","Speech processing and reading are essential unique human abilities underpinning social, educational, and professional advancement. However early biomarkers for learning disabilities such as Developmental Dyslexia (DD) and for second language learning have yet to be identified. Here, cutting edge neuroimaging tools, carefully designed tasks, and longitudinal designs will be used to record cortical tracking of speech (CTS), namely, the temporal alignment between fluctuations in the speech signal a",{"id":113,"funder":7,"programme":8,"title":114,"piName":14,"institution":115,"country":12,"year":13,"amount":116,"abstract":117},"cordis-european-research-council-award-101199875","Generative Spatial Synthesis of Sound and Music","UNIVERSITE PARIS 8 VINCENNES SAINT-DENIS","€2,467,853","Machine learning is particularly well-suited to the processing of ill-defined problems, where complexity rules out direct solutions; it is therefore of paramount importance in the field of music creation, where compositional knowledge is far from explicit. Until now, the generation of sound spaces has often been neglected in the application of AI to music and sound, whereas 3D spatial audio is undergoing significant industrial development.The G3S research project, designed by and for musicians a",{"id":119,"funder":7,"programme":8,"title":120,"piName":14,"institution":121,"country":33,"year":13,"amount":122,"abstract":123},"cordis-european-research-council-award-101199099","Resolving Evolving Aspects of Crystal Structure Transformations","UNIVERSITEIT ANTWERPEN","€2,463,858","Knowing the crystal structure at unit cell level is crucial for understanding and controlling the physical properties of materials and thus for advancing the various fields of materials science. However, for many materials, the arrangement of the atoms within the unit cell varies over nanoscale domains, especially after reactions or under the influence of external factors. Current techniques, such as three-dimensional electron diffraction, X-ray diffraction and atomic resolution imaging techniqu",{"id":125,"funder":7,"programme":8,"title":126,"piName":14,"institution":127,"country":128,"year":13,"amount":91,"abstract":129},"cordis-european-research-council-award-101142013","Brainstem circuit ensembles for movement flexibility","KAROLINSKA INSTITUTET","SE","Movement is the shared language of behavior across the animal kingdom, orchestrated by dedicated circuits throughout the central nervous system. To survive, animals must move with a high degree of flexibility, requiring precise and rapid changes in speed and trajectory. This flexibility of locomotion depends on the brain's ability to select appropriate motor programs and coordinate body and appendage muscles to match the locomotor movement parameters to the behavioral context. In particular, the",{"id":131,"funder":7,"programme":8,"title":132,"piName":14,"institution":133,"country":134,"year":13,"amount":91,"abstract":135},"cordis-european-research-council-award-101200243","Advancing Gene Transfer Capabilities","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","NL","Innovation: We recently developed a targeted lipid nanopar We recently developed a targeted lipid nanoparticle (tLNP) that can insert a gene directly into the genome of T cells in vivo, with efficiency comparable to viral methods. This innovation creates a unique opportunity to track gene delivery using barcoded synthetic vectors. These barcodes help us understand the key factors needed for effective DNA delivery and the biological consequences of gene transfer.Background: Gene therapy holds gre",{"id":137,"funder":7,"programme":8,"title":138,"piName":14,"institution":139,"country":140,"year":13,"amount":141,"abstract":142},"cordis-european-research-council-award-101200505","Classical and Semiclassical Aspects of Amplitudes","THE UNIVERSITY OF EDINBURGH","UK","€2,491,053","Recently, an entirely new class of observable in quantum field theory has been discovered. These observables, which I discovered with my collaborators, make contact with the exciting physics of gravitational waves, and have been used to determine the state-of-the-art expression for the gravitational waveform emitted as two black holes scatter. Yet these observables, given in terms of scattering amplitudes, also lead to a number of major open questions:1. How can we compute bound state gravitatio",{"id":144,"funder":7,"programme":8,"title":145,"piName":14,"institution":146,"country":134,"year":13,"amount":147,"abstract":148},"cordis-european-research-council-award-101142132","Understanding Human-Robot Bonding to Optimize Personal Support","STICHTING VU","€3,195,850","Robots are rapidly entering the human arena as social entities to support education and healthcare where human resources fall short. The ease and naturalness with which humans interact with social robots forebode a high potential but also present new scientific challenges. I see a paradox of nt wanting to emulate humans in robots but still create the human feel in connectedness. Ample research has been done in engineering, design and computer sciences, yet, the question from a human perspective ",{"id":150,"funder":7,"programme":8,"title":151,"piName":14,"institution":152,"country":40,"year":13,"amount":91,"abstract":153},"cordis-european-research-council-award-101201611","Controlled Dynamics in Cold Quantum Matter","UNIVERSITAET INNSBRUCK","Quantum physics lies at the heart of many phenomena in modern physics, from the microscopic world to in superconductors, topological insulators, and quantum magnets. In many cases the ground-state properties are understood, but dynamical processes in interacting quantum many-body systems largely evade a general understanding. One way of circumventing the computational complexity challenge is to engineer artificial model systems in order to quantum-simulate with high control the properties and dy",{"id":155,"funder":7,"programme":8,"title":156,"piName":14,"institution":157,"country":33,"year":13,"amount":158,"abstract":159},"cordis-european-research-council-award-101200830","(Re)constructing the liver, brick by brick","VIB VZW","€2,499,920","Mammals display an abundant capacity for organ growth in the neonatal window but lose this capacity in adulthood. The adult liver maintains some regenerative capacity, but this remains far below the neonatal growth capacity. The adult liver can replenish up to 70% of its mass after surgical resection. However, resection of larger volumes induces liver failure, which causes death of one in three patients. For decades hepatologists have tried to pharmacologically augment hepatocyte proliferation t",{"id":161,"funder":7,"programme":8,"title":162,"piName":14,"institution":163,"country":12,"year":13,"amount":164,"abstract":165},"cordis-european-research-council-award-101142461","Can blue economy interventions mitigate rural poverty and outmigration in land-drying eastern Africa?","UNIVERSITE DE MONTPELLIER","€2,497,250","Coastal and rural villages in Eastern Africa are more likely to have mitigated or even avoided poverty and outmigration during the last three decades of land desertification and natural disasters when developing a sustainable blue economy providing alternative resources and livelihoods. To test this core hypothesis, we will rely on a long-term causal inference framework combining satellite imagery, artificial intelligence algorithms, and spatial matching statistical methods, but also multidiscip",{"id":167,"funder":7,"programme":8,"title":168,"piName":14,"institution":169,"country":26,"year":13,"amount":170,"abstract":171},"cordis-european-research-council-award-101139828","Optoelectronic and all-optical hyperspin machines for large-scale computing","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","€2,490,000","Efficient hardware for combinatorial optimization and machine learning impacts science, engineering, and society. With new computational models, photonics tackle problems intractable with conventional computing systems. However, existing devices only scale up to thousands of spins and operate at the second timescale. I demonstrate photonic machines for ultrafast parallel processing of millions of spins with microsecond timescale. The strategy is minimizing a class of functions, the Ising Hamilto",{"id":173,"funder":7,"programme":8,"title":174,"piName":14,"institution":175,"country":176,"year":13,"amount":177,"abstract":178},"cordis-european-research-council-award-101141273","Linking the scales towards non-conventional polymer composite structures","INEGI - INSTITUTO DE CIENCIA E INOVACAO EM ENGENHARIA MECANICA E ENGENHARIA INDUSTRIAL","PT","€3,493,788","The reduction of the environmental footprint of aviation relies on the development and fast deployment of lighter and more efficient polymer composite structures; however, the current configurations of composite aerospace structures result in a highly constrained design space. Additionally, the limitations of the state-of-the-art analysis methods result in overly conservative designs and in time-consuming certification methodologies. As a result, composite laminates have only contributed to mode",{"id":180,"funder":7,"programme":8,"title":181,"piName":14,"institution":182,"country":12,"year":13,"amount":183,"abstract":184},"cordis-european-research-council-award-101197637","Using electromechanical stimulations on bone remodeling to speed-up repair bone damage","UNIVERSITE DE LORRAINE","€2,574,732","Osteoporosis is a major concern in Europe, resulting in 4.3 million fragility fractures and health care costs in excess of €56 billion annually. Bone, a smart material, can detect microcracks or microdamages and to repair these microdefects due to its growth and remodeling capabilities in the presence of electro-mechanical stimuli. Dry and wet bone involve matrix piezoelectricity, namely a coupling between deformation and polarization. Flexoelectricity, the phenomenon coupling deformation gradie",{"id":186,"funder":7,"programme":8,"title":187,"piName":14,"institution":188,"country":189,"year":13,"amount":190,"abstract":191},"cordis-european-research-council-award-101201768","ExploriNg Lightning Initiation and Gamma-ray High-energy emission in Thunderstorm ENvironments","UNIVERSITETET I BERGEN","NO","€3,500,000","Lightning strikes earth 45 times each second, but we still don’t understand exactly what initiates it. The large electric fields in thunderclouds are also responsible for charged particle acceleration, ultimately leading to gamma-ray production. Energetic radiation is an essential component of thundercloud dynamics. Energetic radiation and lightning discharge appear tightly linked, but the nature of this link is yet to be understood. ENLIGHTEN posits a causal relationship between energetic radia",{"id":193,"funder":7,"programme":8,"title":194,"piName":14,"institution":195,"country":79,"year":13,"amount":196,"abstract":197},"cordis-european-research-council-award-101200584","AI-Twins of Human Experience: Towards Personal Generative AI-Systems for Amplifying Human Cognition","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€2,495,475","We aim to establish a scientific foundation for AI-twins of human experience - personalized multi-modal generative AI systems that capture and encode an individual’s real-world experiences and tacit knowledge. Through continuous data capture from wearable devices, we will explore and develop AI-twins as advanced personal systems for storing and processing human experiences. We believe AI-twins can augment human cognitive and social abilities and enhance human executive functions such as memory c",{"id":199,"funder":7,"programme":8,"title":200,"piName":14,"institution":201,"country":176,"year":13,"amount":202,"abstract":203},"cordis-european-research-council-award-101140664","Facial Recognition Technologies. Etho-Assemblages and Alternative Futures","ASSOCIACAO ISCTE CONHECIMENTO E INOVACAO - CENTRO DE VALORIZACAO E TRANSFERENCIA DE TECNOLOGIAS","€2,467,635","Facial recognition technologies collect billions of faces that are stored for multiple uses spanning individual identification and tracking, to training of deep neural networks, the mainstay of modern artificial intelligence (AI). From tagging a photo on social media or unlocking a computer, to controversial applications of facial recognition in public spaces, schools, workplaces, and law enforcement activities, facial processing technologies have entered almost every aspect of our lives. While ",{"id":205,"funder":7,"programme":8,"title":206,"piName":14,"institution":207,"country":79,"year":13,"amount":208,"abstract":209},"cordis-european-research-council-award-101141624","Harnessing Specialized Metabolism from Anaerobes","LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-INSTITUT","€2,499,859","Anaerobic bacteria, a group of microorganisms that thrive in the absence of oxygen, have a significant impact on the quality of life on Earth. They play a crucial role in biotechnology and are essential components of the gut microbiota. As such, they are of tremendous importance for human, animal, and environmental health. On the other hand, certain anaerobes can be life-threatening pathogens. In light of this, there is an urgent need for a deeper understanding of the specialized metabolites of ",{"id":211,"funder":7,"programme":8,"title":212,"piName":14,"institution":195,"country":79,"year":13,"amount":213,"abstract":214},"cordis-european-research-council-award-101198605","The hidden heritage of modern logic","€2,294,070","The project's aims are the transcription from shorthand and study of the writings of Kurt Gödel, Gerhard Gentzen, and Paul Bernays on the main problem of the foundations of mathematics, namely the consistency of analysis. These rich sources have remained inaccessible because of their archaic shorthand. Previous work by the PI on Gödel's and Gentzen's shorthand notes has led to stunning discoveries published in many articles and eight books, but it has left the said main problem untouched. The mo",{"id":216,"funder":7,"programme":8,"title":217,"piName":14,"institution":218,"country":140,"year":13,"amount":219,"abstract":220},"cordis-european-research-council-award-101199104","Ultrafast Photochemistry in Organic Aerosols","UNIVERSITY OF BRISTOL","€3,197,095","Much of the current discussion of the causes of global warming and mitigation of its impacts focuses on greenhouse gas emissions and net-zero CO2 targets. However, atmospheric aerosols also contribute significantly, and in ways that remain more poorly quantified, to the radiative balance that determines Earth’s climate. The PHAERO project addresses a major gap in our knowledge of the sunlight-driven photochemistry of organic aerosol particles in the lower atmosphere. For the first time, PHAERO w",{"id":222,"funder":7,"programme":8,"title":223,"piName":14,"institution":224,"country":33,"year":13,"amount":225,"abstract":226},"cordis-european-research-council-award-101142065","Revolutionizing Olefin Production with the electric High Mach Steam Cracking Reactor","UNIVERSITEIT GENT","€2,496,000","Power to heat (P2H) is expected to be the first type of electrification that will drastically transform the chemical industry. This holds in particular for producing its major building blocks: the 300 Mt\u002Fyr light olefins via steam cracking at more than 800°C. e-CRACKER will implement P2H by so-called shockwave heating, enabling an increase in temperature to >1000°C in 10 ms, an order of magnitude faster than the current furnace-based technology in a revolutionary High-Mach reactor. When combined",{"id":228,"funder":7,"programme":8,"title":229,"piName":14,"institution":230,"country":140,"year":13,"amount":231,"abstract":232},"cordis-european-research-council-award-101199732","Colonial credit and financial diversity in the Global South: Spanish America 1600-1820","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€2,475,855","Did the Spanish Empire bequeath weak credit markets to Spanish American Republics? Scholars cite a colonial legacy of extractive institutions as the root cause of financial and fiscal crises in Spanish America since Independence (1808-20s). Colonial credit was archaic. Modern European private banking institutions only arrived in Spanish America after 1850. The credit sector remained unstable, failed to service large parts of the population, and the cost of capital (the interest rate) was very hi",{"id":234,"funder":7,"programme":8,"title":235,"piName":14,"institution":230,"country":140,"year":13,"amount":236,"abstract":237},"cordis-european-research-council-award-101201023","Adjoint-accelerated Inference and Optimization Methods","€2,493,667","The proposed research will demonstrate, with industrial examples, how scientists and engineers can efficiently combine data with prior physical knowledge. It will leverage Bayesian inference for rigour, adjoint methods for speed, and fluid dynamics for impact. Bayesian inference has been applied to fluid dynamics before but rarely using adjoint-accelerated inference and optimization methods (AXIOMs). These methods are crucial for practical applications because they dramatically accelerate data a",{"id":239,"funder":7,"programme":8,"title":240,"piName":14,"institution":127,"country":128,"year":13,"amount":241,"abstract":242},"cordis-european-research-council-award-101199477","Pharmacological and gene therapy targeting of NMNAT2 for neuroprotection in glaucoma","€2,261,875","The goal of this ERC Advanced Grant is to develop clinically translatable neuroprotective strategies for glaucoma by focusing on NAD metabolism. NMNAT2 is a neuron-specific NAD-generating enzyme and is the upstream enzyme that coordinates axon degeneration. The Williams lab is expert in taking basic biological findings in glaucoma to the clinic, and we will leverage our expertise in this space to develop novel clinically translatable therapeutic interventions for glaucoma based on NMNAT2 biology",{"id":244,"funder":7,"programme":8,"title":245,"piName":14,"institution":146,"country":134,"year":13,"amount":246,"abstract":247},"cordis-european-research-council-award-101141972","A Principled Plan to Prevent Transient Execution Attacks","€2,499,995","Ghostbuster is a research program to stop advanced transient execution attacks, which by themselves already rank among the most advanced attacks everby finding vulnerable code fragments, analyzing them for exploitability, and injecting mitigations where needed. The vulnerabilities such as Spectre, Meltdown and others originate in vulnerable hardware and allow data leakage across all security boundaries. Recently, my team and I showed that even more advanced attacks exist by combining transient e",{"id":249,"funder":7,"programme":8,"title":250,"piName":14,"institution":251,"country":12,"year":13,"amount":252,"abstract":253},"cordis-european-research-council-award-101201475","Uncovering the hidden origin behind the missing heritability","UNIVERSITE DE STRASBOURG","€2,499,625","Understanding the genetic causes of phenotypic diversity in natural populations is a major challenge. While advances have been made in identifying the genetic basis of complex traits, our knowledge remains incomplete. Whole-genome sequencing has enabled genome-wide association studies (GWAS) to link genetic variants to traits, including human diseases. However, even with thousands of causal variants identified, they often account for only a small fraction of phenotypic variation. Uncovering the ",{"id":255,"funder":7,"programme":8,"title":256,"piName":14,"institution":257,"country":134,"year":13,"amount":258,"abstract":259},"cordis-european-research-council-award-101201005","The rhythms of our mind. A mechanistic model of how oscillating body-brain states structure human cognition","UNIVERSITEIT MAASTRICHT","€2,499,692","We live in a rhythmic world. Take a deep breath, listen to your heartbeat, to the trees swinging with the wind, music playing, people chatting. Every perception and cognition, every heartbeat happens in time following its own rhythmic frequency. Our brain also generates rhythmic brain waves and there is wide consensus that these neural oscillations are a fundamental building block of how our brain works. Interestingly, the brain is not the only organ generating such intrinsic rhythmic signals. B",{"id":261,"funder":7,"programme":8,"title":262,"piName":14,"institution":263,"country":79,"year":13,"amount":264,"abstract":265},"cordis-european-research-council-award-101200794","DNA-binding domain Conditioned Precision Genome Editing","TECHNISCHE UNIVERSITAET DRESDEN","€2,386,205","Genome editing in human therapies has the potential to revolutionize modern medicine. With numerous clinical trials underway and the recent approval of the first genome editing therapy, the field is rapidly advancing. However, there is a consensus that clinical genome editing tools must be efficient, precise and safe. Current tools predominantly rely on host cell DNA repair pathways to complete the editing process, which poses a risk for unintended editing events. Host cell DNA repair independen",{"id":267,"funder":7,"programme":8,"title":268,"piName":14,"institution":224,"country":33,"year":13,"amount":225,"abstract":269},"cordis-european-research-council-award-101199664","Interactively connecting our polymer production design","A challenge in the polymer industry is the design of molecular and morphological properties along the whole production chain, minimizing energy consumption and product heterogeneity, and ensuring recyclability. Ideally, we need to track the compositional\u002Ftopological variations and interactions of individual species during (i) synthesis, hence, the polymer reaction engineering (PRE) stage; and (ii) downstream final material shaping, hence, the polymer processing (PP) stage (e.g. (reactive) extrus",{"id":271,"funder":7,"programme":8,"title":272,"piName":14,"institution":273,"country":189,"year":13,"amount":274,"abstract":275},"cordis-european-research-council-award-101142277","Breaching the boundaries of safety and intelligence in autonomous systems with risk-based rationality","NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU","€2,499,773","Autonomous systems able to comprehensively assess and model risks would be a scientific breakthrough leading to highly intelligent system behaviors, safe interactions in unstructured environments, and public trust. Currently, risk perception is an important part of human cognition not adequately implemented in the situation awareness, control and decision-making of autonomous systems. Therefore, this project addresses fundamental research challenges related to risk-based autonomy and safe and ef",{"id":277,"funder":7,"programme":8,"title":278,"piName":14,"institution":279,"country":189,"year":13,"amount":280,"abstract":281},"cordis-european-research-council-award-101141825","Linguistic traces: low-frequency forms as evidence of language and population history","UNIVERSITETET I STAVANGER","€2,498,135","We know remarkably little about the early history that formed the known European languages and cultures. While advances in genetics have led to new debates about population histories, they cannot tell us about the languages spoken. In the absence of written records, language appears ephemeral: changes through time seemingly erase all traces of earlier speech, leaving only abstract ‘proto-languages’ to be reconstructed.Such erasures are not, however, complete, as language change always leaves beh",{"id":283,"funder":7,"programme":8,"title":284,"piName":14,"institution":285,"country":26,"year":13,"amount":286,"abstract":287},"cordis-european-research-council-award-101142079","Pulsar timing array Inference of the Nanohertz Gravitational wave Universe","UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA","€2,291,444","We are on the verge of the next big breakthrough in gravitational wave (GW) astronomy: namely the detection of a nano-Hz GW signal with Pulsar Timing Arrays (PTAs). Within the next few years nano-Hz GWs will be established as a completely new window on our Universe, unlocking an unprecedented opportunity to unveil its secrets. The signal is anticipated to come from a cosmic population of supermassive black hole binaries (SMBHBs), which are a fundamental, yet observationally missing, piece in the",{"id":289,"funder":7,"programme":8,"title":290,"piName":14,"institution":291,"country":292,"year":13,"amount":293,"abstract":294},"cordis-european-research-council-award-101142769","Local-to-global Expansion and PCPs","WEIZMANN INSTITUTE OF SCIENCE","IL","€2,105,840","This proposal aims to delve further into the study of Probabilistically Checkable Proofs (PCPs), a cornerstone of modern theoretical computer science, that exhibits some of the most powerful local to global behavior. Any NP proof can be written in a format that is locally testable, meaning that local pieces of the proof imply very rich global structure. This theory is strongly tied to hardness of approximation and has significant applications in cryptography. A major goal is to develop simpler a",{"id":296,"funder":7,"programme":8,"title":297,"piName":14,"institution":298,"country":79,"year":13,"amount":91,"abstract":299},"cordis-european-research-council-award-101141768","Decode and Cure primary Focal Segmental Glomerulosclerosis","UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF","Kidney diseases are a worldwide rising major health problem associated with an excess risk for cardiovascular disease and reduced life expectancy. While general risk factors for kidney diseases such as diabetes and hypertension are being addressed through numerous research efforts, causes of specific glomerular kidney diseases, especially Focal Segmental Glomerulosclerosis (FSGS), remain poorly understood. FSGS is the most common glomerular cause of end stage renal disease characterized by scari",{"id":301,"funder":7,"programme":8,"title":302,"piName":14,"institution":195,"country":79,"year":13,"amount":303,"abstract":304},"cordis-european-research-council-award-101141463","Buddhism’s Early Spread to Tibet: Dunhuang and the Influence of Sinitic Scriptures","€2,499,809","Modern scholarship follows emic accounts in situating the origins of Tibetan Buddhism squarely in India, tacitly accepting Tibets claim to be heir to the orthodox tradi-tion. This oversimplifies the complex history of Buddhisms two transmissions to Tibet, in the 7th and 11th centuries, elid-ing the formative early contributions of Sinitic sources, principally imparted from the Silk Road oasis of Dunhuang, a crucial locus of interaction between Tibetan and Chinese cultures in the 8th-11th centuri",{"id":306,"funder":7,"programme":8,"title":307,"piName":14,"institution":308,"country":128,"year":13,"amount":309,"abstract":310},"cordis-european-research-council-award-101141787","Exploring social (im)perceptibility","UPPSALA UNIVERSITET","€2,499,839","Recent years have seen previously largely unnoticed groups—frontline health workers, workers along global supply chains, victims of sexual abuse, people who subscribe to outlandish conspiracy theories—suddenly appearing in the limelight. This project takes a step back and documents the processes through which some people come to be unnoticed in the first place. NOTREALLYTHERE aims to transform sociologist Erving Goffman’s well-known but undertheorized concept of “non-person” into a fresh field o",{"id":312,"funder":7,"programme":8,"title":313,"piName":14,"institution":314,"country":26,"year":13,"amount":315,"abstract":316},"cordis-european-research-council-award-101142420","Ethics and Moral Life in the 18th Century: A New  Take on Early Modern Ethics","UNIVERSITA DEGLI STUDI DI MILANO","€1,463,694","Early modern ethics has so far been investigated with regard to the debates on the foundations of morality, moral knowledge and the status of moral principles. Despite their achievements, the main limit of previous studies is that they have largely disregarded the distinctive purpose of ethics in that age, that is, to provide guidance about specific moral issues. Even the discussion on the abstract topics on which most studies have focused was in fact sustained by the purpose of providing the ap",{"id":318,"funder":7,"programme":8,"title":319,"piName":14,"institution":320,"country":110,"year":13,"amount":321,"abstract":322},"cordis-european-research-council-award-101142583","Socio-Economic Challenges and Opportunities of the Energy Transition","FUNDACION CENTRO DE ESTUDIOS MONETARIOS Y FINANCIEROS","€2,499,440","ENERGY-IN-TRANSITION will push the frontier in energy and environmental economics by addressing and quantifying novel socioeconomic challenges and opportunities that arise as the Energy Transition moves forward. Firstly, there is an urgent need to design new Energy Transition policies while re-designing existing ones. In particular, the prospect that Green Hydrogen might help reduce our dependency on fossil fuels has accelerated the need to define its regulation. Likewise, the recent energy cris",{"id":324,"funder":7,"programme":8,"title":325,"piName":14,"institution":326,"country":140,"year":13,"amount":327,"abstract":328},"cordis-european-research-council-award-101201596","New International Monetary and Financial Environment","LONDON BUSINESS SCHOOL","€2,123,166","The structure of the international monetary and financial system has first-order implications for capital flows, financial stability, the value of currencies and the way shocks propagate across countries. The world is changing rapidly: the share of the United States and Europe in international trade has declined, while the share of Asia has increased since the 2000s. International finance is still dominated by the US dollar, but China is emerging. There are wealth transfers due to the restructur",{"id":330,"funder":7,"programme":8,"title":331,"piName":14,"institution":332,"country":140,"year":13,"amount":333,"abstract":334},"cordis-european-research-council-award-101198667","Muscular Faith: The Interplay between Sport and Religion in Africa","SCHOOL OF ORIENTAL AND AFRICAN STUDIES ROYAL CHARTER","€2,278,936","Many young African lives are paused in ‘waithood’ (Honwana 2012): no longer children but unable to become independent adults. Many manage this situation through sport, religion, or both. The question at the heart of MFA is how sport and religion in tandem provide a way out of ‘waithood’.Sport and religion alternately reference each other as performance enhancers. Both have been posited as catalysts for development and integration, however, their interplay remains under-theorised. Social science ",{"id":336,"funder":7,"programme":8,"title":337,"piName":14,"institution":291,"country":292,"year":13,"amount":338,"abstract":339},"cordis-european-research-council-award-101198942","Neuroscience in the real world: Representation of position, direction and environmental borders in the hippocampal formation of bats navigating outdoors on a remote oceanic island","€3,124,999","Navigation is a key behavior, studied by multiple research fields. In ethology, wild animals are tracked outdoors using GPS tags as they navigate hundreds of meters or kilometers. In neuroscience, experiments are very different: laboratory animals are tracked inside small ~1×1-meter boxes, while recording the activity of navigation-related neurons – such as place cells, grid cells, head-direction cells, and border cells.  However, it is unknown whether these spatial neurons, as studied in small ",{"id":341,"funder":7,"programme":8,"title":342,"piName":14,"institution":343,"country":292,"year":13,"amount":344,"abstract":345},"cordis-european-research-council-award-101198899","Reducing self-and other-directed ageism in the second half of life","BAR ILAN UNIVERSITY","€2,499,967","HALFLIFE proposes groundbreaking research to understand ageism (i.e., stereotypes, prejudices, and discrimination towards people because of their age) in the second half of life (defined as age 60 and over) to unveil evidence-based interventions to reduce ageism. Unlike other “isms”, we are all bound to experience ageism if we live long enough. The evolving ageing demographics and the detrimental impact of ageism on society at large and older persons alike make the reduction of ageism a public h",{"id":347,"funder":7,"programme":8,"title":348,"piName":14,"institution":349,"country":79,"year":13,"amount":350,"abstract":351},"cordis-european-research-council-award-101200429","Probabilistic photonic computing","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","€3,468,472","The neuroscience principle of free energy minimization (FEM) suggests that living organisms create internal models of their environment in order to minimize surprise and manage uncertainty. This is strikingly different from artificial neural networks (ANNs), which prioritize maximizing accuracy. Although ANNs excel in applications such as natural language processing and weather forecasting, they struggle with real-time, safety-critical tasks like autonomous navigation due to their reliance on de",{"id":353,"funder":7,"programme":8,"title":354,"piName":14,"institution":355,"country":292,"year":13,"amount":356,"abstract":357},"cordis-european-research-council-award-101201649","Computational Complexity of Noisy and Perturbed Quantum Systems","THE HEBREW UNIVERSITY OF JERUSALEM","€2,498,125","The field of quantum computation has matured tremendously since the early remarkable discoveries of exponential quantum algorithms speed ups, quantum error correction and fault tolerance. However, some of the most basic, fundamental questions, remain a challenge. What are the conditions for quantum fault tolerance, and what are its fundamental limitations? What other problems admit quantum algorithmic speed ups, and how can we design new quantum algorithms? Can quantum Hamiltonian complexity be ",{"id":359,"funder":7,"programme":8,"title":360,"piName":14,"institution":355,"country":292,"year":13,"amount":361,"abstract":362},"cordis-european-research-council-award-101199203","Dynamics, Additive number theory and Algebraic geometry","€2,223,500","The last two decade have witnessed a new spring for dynamical systems. The field - initiated by Poincare in the study of the N-body problem - has become essential in the understanding of seemingly far off fields such as combinatorics, number theory, and theoretical computer science. In particular, ideas from ergodic theory played an important role in the resolution of long standing open problems in combinatorics and number theory. A striking example is the role of dynamics on nilmanifolds in the",{"id":364,"funder":7,"programme":8,"title":365,"piName":14,"institution":308,"country":128,"year":13,"amount":91,"abstract":366},"cordis-european-research-council-award-101200073","Elucidating structures and functions in the arachnoid barrier","Less is known about the structural and functional importance of the arachnoid barrier than any other CNS barrier, including the blood-brain barrier. Animal models of arachnoid barrier impairment are not known\u002Fhave not been analyzed. The sophisticated architecture and cellular specialization of the arachnoid barrier includes tight- and tricellular junctions joining two cell layers, direct contact with other arachnoid cells, and the specific expression of a broad repertoire of influx and efflux tr",{"id":368,"funder":7,"programme":8,"title":369,"piName":14,"institution":370,"country":33,"year":13,"amount":371,"abstract":372},"cordis-european-research-council-award-101200365","Experimental Continuation in Nonlinear Dynamics: Aerospace Engineering and Beyond","UNIVERSITE DE LIEGE","€2,404,187","Nonlinear vibration theory witnessed extraordinary advances during the 20th century following Poincaré’s seminal work. Since the 1970s, impressive progress has been made in computational nonlinear dynamics with the development of nonlinear finite element methods and numerical continuation. Although not all challenges have been overcome yet, the theoretical understanding of nonlinear dynamical phenomena and their prediction using numerical models have reached a high level of maturity. Surprisingl",{"id":374,"funder":7,"programme":8,"title":375,"piName":14,"institution":376,"country":377,"year":13,"amount":378,"abstract":379},"cordis-european-research-council-award-101199298","Inclusive History of East-Central Europe:  Mid-19th Century to Present","UNIVERZITA KARLOVA","CZ","€2,499,900","INHIST is based on the premise that current efforts to build an inclusive society urgently require education that offers an inclusive and multivocal interpretation of our past. Official interpretations of modern European history, especially of East-Central European (ECE) states, are still dominated by a narrow vision of the one-nation state. INHIST offers an alternative in the form of an inclusive history of ECE, in which history from the mid-19th century to present is analyzed from the perspect",{"id":381,"funder":7,"programme":8,"title":382,"piName":14,"institution":355,"country":292,"year":13,"amount":383,"abstract":384},"cordis-european-research-council-award-101200284","Continual learning and memory for sounds in rat","€2,497,500","How much can we remember and for how long? Decades of key advances in our understanding of synaptic plasticity resulted in a puzzle. On the one hand, memories can be highly stable and organisms are capable of adding new memories without destroying old ones. On the other hand, data and models support neither stability nor lifelong (‘continual’) learning. Many experiments suggest that responses of neuronal populations slowly but inexorably drift (“representational drift”), while synapses spontaneo",{"id":386,"funder":7,"programme":8,"title":387,"piName":14,"institution":388,"country":12,"year":13,"amount":389,"abstract":390},"cordis-european-research-council-award-101200507","The German Sources of Ecology","UNIVERSITE PARIS III SORBONNE NOUVELLE","€1,500,000","Originally, ‘ecology’ was more than just the name of a biological subdiscipline. When its inventor, the German biologist Ernst Haeckel, first coined the term (German: ‘Oecologie’) in his 1866 work General Morphology, he was in fact shaping the contours of a larger philosophical project rooted in German anthropology and aesthetics. The aim of this ERC research project is to uncover this forgotten enterprise and to assess its implications. To do so, it proposes a radical change of perspective, bro",{"id":392,"funder":7,"programme":8,"title":393,"piName":14,"institution":314,"country":26,"year":13,"amount":394,"abstract":395},"cordis-european-research-council-award-101201013","Forensic anthropological Identification to Name the Dead Migrants in Europe","€2,495,613","FIND ME addresses the pressing humanitarian and forensic challenge of identifying deceased migrants who have perished in or at the borders of Europe. As migration flows increase, so does the number of unidentified bodies, posing significant difficulties for both authorities and families. Today’s forensic pillars of identification such as DNA are failing to identify economically disadvantaged groups and migrants, because dental charts and fingerprints of these missing persons, as well as DNA from",{"id":397,"funder":7,"programme":8,"title":398,"piName":14,"institution":399,"country":12,"year":13,"amount":400,"abstract":401},"cordis-european-research-council-award-101199575","Unifying Graph Databases and Causal Models","UNIVERSITE LYON 1 CLAUDE BERNARD","€2,315,565","Graphs are expressive data structures representing more effectively relationships in data and enabling complex data-intensive tasks. Graphs are also a widely adopted paradigm in causal inference focusing on causal directed acyclic graphs. Causal DAGs (Directed Acyclic Graphs) are manually curated by domain experts, but they are not validated, stored, integrated and versioned as data artifacts in a graph data system. In the GOY (pronounced GO Why) project, I focus on a radical shift towards causa",{"id":403,"funder":7,"programme":8,"title":404,"piName":14,"institution":405,"country":12,"year":13,"amount":406,"abstract":407},"cordis-european-research-council-award-101141472","Innovative and sustainable carbon-based composites for high temperature sensible thermal energy storage","INSTITUT MINES-TELECOM","€2,494,415","Although affordable solutions exist to store and recover heat from low temperature sources, the high temperature ones (> 550 °C) such as the concentrated solar and waste heat from high temperature energy intensive industries remain challenging since efficient and affordable storage materials are scarce. The waste heat from these industries is huge and corresponds to 16% (122 Terawatt hours) of the total heat consumption\u002Fyear in Europe.STOREHEAT targets the investigation of an outstanding and nov",{"id":409,"funder":7,"programme":8,"title":410,"piName":14,"institution":411,"country":110,"year":13,"amount":412,"abstract":413},"cordis-european-research-council-award-101198688","Age-associated antigens in atherosclerosis immunity and immunotherapy","CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)","€2,495,995","Cardiovascular disease remains the leading cause of mortality worldwide, with atherosclerosis (AT) as the primary underlying factor. Ageing is the strongest risk factor for both AT and CVD. Emerging evidence indicates that the B cell-mediated immune response plays a pivotal role in the development and progression of AT, although the nature of this response and its triggering antigens are poorly understood. In our prior research, we identified ALDH4A1 as novel AT antigen and showed that anti-ALDH",{"id":415,"funder":7,"programme":8,"title":416,"piName":14,"institution":417,"country":140,"year":13,"amount":418,"abstract":419},"cordis-european-research-council-award-101201180","In with the good, out with the bad: understanding small molecule influx and efflux in gut Bacteroides.","UNIVERSITY OF NEWCASTLE UPON TYNE","€2,883,565","The human gut microbiome can be considered a virtual organ that has a profound influence on many aspects of human health. While very diverse at the species level, the human gut microbiome is dominated by just two bacterial phyla, the Gram-positive Firmicutes and the Gram-negative Bacteroidetes. The Bacteroides genus belongs to the Bacteroidetes phylum and is the most abundant genus within the gut of western world populations. Due to their abundance and their well-characterised ability to break d",{"id":421,"funder":7,"programme":8,"title":422,"piName":14,"institution":423,"country":292,"year":13,"amount":91,"abstract":424},"cordis-european-research-council-award-101198411","Harnessing Non-Classical Carbocations for Stereoselective Synthesis","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","Stereoselective synthesis is a central aspect of modern organic chemistry, enabling the precise formation of specific stereoisomers in complex molecular architectures. Key to this process are reactive intermediates such as carbenes, radicals, and carbocations. However, achieving complete stereocontrol over non-classical carbocations in the stereoselective synthesis of acyclic molecules remains a formidable challenge.These fascinating carbocations, despite decades of research, exhibit unpredictab",{"id":426,"funder":7,"programme":8,"title":427,"piName":14,"institution":423,"country":292,"year":13,"amount":428,"abstract":429},"cordis-european-research-council-award-101142322","Cryptography from Unstructured Hardness","€2,496,250","Cryptography—and its basic tasks such as encryption, authentication and key exchange—is essential for ensuring privacy and security on the Internet. The question of whether “unbreakable” encryption methods exist has fascinated mathematicians and cryptographers for thousands of years, and is closely related to the famous NP vs. P problem. This question is still wide open and consequently, Internet security today relies on cryptographic constructions based on the *conjectured* hardness of some com",{"id":431,"funder":7,"programme":8,"title":432,"piName":14,"institution":433,"country":40,"year":13,"amount":91,"abstract":434},"cordis-european-research-council-award-101199096","Synaptic engrams in hippocampal CA3 memory circuits","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","A fundamental question in neuroscience is how information in brain circuits is stored and retrieved. However, the physical and chemical changes underlying the formation of memories, or “engrams”, are largely elusive. Although recent work identified engram cells, the nanoscopic changes at synapses during engram formation remain unclear. New experimental techniques allow us to probe the subcellular and synaptic components of the engram: functional analysis by multicellular electrophysiology, struc",{"id":436,"funder":7,"programme":8,"title":437,"piName":14,"institution":438,"country":79,"year":13,"amount":439,"abstract":440},"cordis-european-research-council-award-101199131","Shifting Mindsets for Sustainable Consumption","RUHR-UNIVERSITAET BOCHUM","€2,497,526","Unsustainable consumption is a key driver of the climate crisis and must be urgently addressed to stay within planetary boundaries. Despite widespread awareness, personal lifestyle changes have proven insufficient and difficult. Rather than relying on individual self-control alone, major structural policy solutions addressing the systemic roots of the social dilemma of unsustainable consumption are needed. Thus, citizens, as well as policymakers, need to become more aware of the significant cons",{"id":442,"funder":7,"programme":8,"title":443,"piName":14,"institution":444,"country":79,"year":13,"amount":445,"abstract":446},"cordis-european-research-council-award-101142019","Uncovering the cortical cellular basis of specificity and chronicity of pain","UNIVERSITATSKLINIKUM HEIDELBERG","€2,468,700","Chronic pain remains a fundamental unsolved puzzle in biology and an unmet global challenge in clinical practice. Progress is limited by major gaps in knowledge on neural substrates, owing to overwhelming redundancy of implicated regions and pathways with several pain-unrelated sensory, cognitive and emotional functions as well as lack of understanding on the origins of plasticity and cellular substrates for diverse psychosocial and environmental influences on pain. Here we propose that neocorti",{"id":448,"funder":7,"programme":8,"title":449,"piName":14,"institution":450,"country":26,"year":13,"amount":91,"abstract":451},"cordis-european-research-council-award-101198414","Nanobody-Targeted  Camk2d Inhibition for Cardiac Arrhythmias","UNIVERSITA DEGLI STUDI DI PAVIA","In cardiac cells, kinase enzymes are key modulators of calcium homeostasis, mitochondrial function, excitation-contraction coupling, and metabolism. Of these, the delta isoform of Ca 2+ \u002FCalmodulin-dependent kinase (Camk2d) is particularly relevant to the induction of life-threatening cardiac arrhythmias.Of the several promising small molecule and peptide Camk2d inhibitors proposed in pre-clinical investigations, none has entered clinical applications. The severity of side effects, a well-known ",{"id":453,"funder":7,"programme":8,"title":454,"piName":14,"institution":455,"country":456,"year":13,"amount":457,"abstract":458},"cordis-european-research-council-award-101142136","Predictive algorithms for simulating quantum materials","UNIWERSYTET WARSZAWSKI","PL","€3,499,299","This project seeks to advance the field of predictive algorithms for quantum many-body systems by developing a next-generation numerical toolset. The project will focus on combining field-theory based methods for both perturbative and non-perturbative ab-initio and model systems with innovations in tensor techniques, quantum Monte Carlo, machine learning, and numerical analysis.By utilizing these innovative methods, we aim to deepen our understanding of quantum phases and exotic properties of ma",{"id":460,"funder":7,"programme":8,"title":461,"piName":14,"institution":462,"country":33,"year":13,"amount":463,"abstract":464},"cordis-european-research-council-award-101200736","Cascade reactions with Zeolites in compartmentalized settings","KATHOLIEKE UNIVERSITEIT LEUVEN","€2,499,718","CaZeo uses zeolites to overcome thermodynamic barriers in cascade processes, instrumentalizing the zeolite micropores to compartmentalize the reaction space. As a pilot case, the endergonic hydrogenation of CO2 to CO inside a small-pore zeolite is coupled to an exergonic homogeneously catalyzed carbonylation of an alkene outside the zeolite, yielding in one step an ester product with a CO2-derived functional group. Critically, undesired alkene hydrogenation is impeded by the narrow zeolite chann",{"id":466,"funder":7,"programme":8,"title":467,"piName":14,"institution":462,"country":33,"year":13,"amount":468,"abstract":469},"cordis-european-research-council-award-101200554","Real-time optimal control of wind-farm atmosphere interaction","€2,458,280","Current Wind-Farm flow Control (WFC) focuses on the interaction of wind turbines through their wakes, and relies on fast heuristic wake models that are mostly considered in an open-loop control framework. However, modern wind farms interact with the atmosphere at much larger scales, such, e.g., as their excitation of atmospheric gravity waves. WFC response is thereby not only governed by intra-farm turbine wakes, but possibly even more by the interaction between the larger atmospheric mesoscales",{"id":471,"funder":7,"programme":8,"title":472,"piName":14,"institution":473,"country":40,"year":13,"amount":474,"abstract":475},"cordis-european-research-council-award-101142352","Tracking the dispersal of Homo sapiens into the Levant and across wider Eurasia","UNIVERSITAT WIEN","€2,944,654","The diaspora of modern humans from Africa into Eurasia and beyond is one of the seminal chapters in the history of our species. Modern humans emerged in Africa by 250-300,000 years ago. Their several subsequent dispersals outwards must have followed one of two routes, the most likely being across the Sinai Peninsula and Levantine corridor. Here, they would have encountered resident Neanderthals and beyond, into Eurasia, the Denisovans. A major dispersal of modern humans by ~50,000 years ago, hyp",{"id":477,"funder":7,"programme":8,"title":478,"piName":14,"institution":479,"country":110,"year":13,"amount":480,"abstract":481},"cordis-european-research-council-award-101141909","Holography in the Gravitational Wave Era","UNIVERSITAT DE BARCELONA","€2,499,451","The revolution unleashed by the discovery of gravitational waves will gradually unfold over the coming decades. The detection of a neutron star merger by LIGO and Virgo opened a new era in multi-messenger astronomy. Future ground-based interferometers, such as the Cosmic Explorer and the Einstein Telescope, will extend the range of detection to the entire Universe, and the frequency to millions of detections per year.  Space-based missions like LISA may discover gravitational waves from phase tr",{"id":483,"funder":7,"programme":8,"title":484,"piName":14,"institution":485,"country":79,"year":13,"amount":486,"abstract":487},"cordis-european-research-council-award-101201672","Targeting rogue DNA repair and genomic instability as novel toxicity mechanisms in C9orf72 ALS\u002FFTD","DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV","€2,498,905","Repeat expansions are a major cause of neurodegenerative diseases, but causal therapies are not available. A (G4C2)n repeat expansion in C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in Europe. Despite extensive research, the mechanisms linking these expansions to selective neurodegeneration remain poorly understood. Our project, epiC9repair, explores the novel hypothesis that genomic instability at the C9orf72 locus, driven by ",{"id":489,"funder":7,"programme":8,"title":490,"piName":14,"institution":491,"country":134,"year":13,"amount":492,"abstract":493},"cordis-european-research-council-award-101199769","Ground Truth for Pebbles in Planet Formation","UNIVERSITEIT VAN AMSTERDAM","€3,492,672","The discovery of exoplanetary systems has triggered a boost in the development of planet formation models. Most of these models rely on the presence of so-called pebbles – dust aggregates that have grown and been compacted in just the right way to be dynamically loosely coupled to the gas in the planet-forming disk. Only then do they enable key processes that produce planetary seeds and grow them efficiently into planets, overcoming growth barriers and enormous time scale problems. The models re",{"id":495,"funder":7,"programme":8,"title":496,"piName":14,"institution":497,"country":40,"year":13,"amount":498,"abstract":499},"cordis-european-research-council-award-101141432","Formal Methods for Secure Blockchain-Oriented Programming","TECHNISCHE UNIVERSITAET WIEN","€2,499,983","Despite their tender age, blockchain technologies  are bringing a profound impact on the society and economy.  The swift technological advancements in this domain, however,   are not always accompanied by solid scientific foundations, which  often follow and try to catch up a posteriori with the proposed engineering solutions. The most prominent examples are smart contracts:  the total value locked in Decentralized Finance (DeFi)  nears 50B USD and, yet, vulnerabilities leading to dramatic finan",{"id":501,"funder":7,"programme":8,"title":502,"piName":14,"institution":503,"country":26,"year":13,"amount":504,"abstract":505},"cordis-european-research-council-award-101201772","charting Immunological Maps of Populations Across Complex disease and lifetime Trajectories","FONDAZIONE HUMAN TECHNOPOLE","€2,499,998","The extending human lifespan and its associated accumulation of morbidities due to chronic disorders calls for new models to accelerate the early detection, prognosis and treatment of chronic conditions. To date, anchoring detailed molecular knowledge of disease processes with diagnoses of chronic diseases from ‘real-world’ biomedical data remains an open challenge.The immune system plays a central role in human health and survival, while deterioration of immune function is implicated in the dev",{"id":507,"funder":7,"programme":8,"title":508,"piName":14,"institution":509,"country":110,"year":13,"amount":510,"abstract":511},"cordis-european-research-council-award-101139298","In situ imaging of low-carbon CEMent hydration with SYNchrotron X-rays","UNIVERSIDAD DE MALAGA","€2,497,880","Concrete, made from Portland cement (PC), water, aggregates, mineral additions and chemical admixtures, is the most manufactured world commodity, 5 t\u002Fperson\u002Fyr. PCs are environmentally contentious, accounting for 8% of anthropogenic CO2 emissions. Hence, developing more durable concretes with lower embodied carbon contents is central to maintaining our well-being. The main drawback of the most ambitious proposals for sustainable low-carbon cements is their slow hydration kinetics in the first th",{"id":513,"funder":7,"programme":8,"title":514,"piName":14,"institution":515,"country":128,"year":13,"amount":516,"abstract":517},"cordis-european-research-council-award-101199467","Nanoscale Analysis of Inter-Organelle Interactions and their Role in Neuronal Plasticity","GOETEBORGS UNIVERSITET","€2,499,861","Cellular communication is mediated by nanometer-sized organelles (vesicles, stress granules, exosomes) that are potentially responsible for carrying and releasing signalling molecules. I propose to use my extensive background in electroanalytical chemistry and mass spectrometry imaging to develop new technologies to chemically dissect vesicles, exosomes, and stress granules both dynamically and in fixed samples with spatial discrimination across living cells - the next frontier in cell analysis.",{"id":519,"funder":7,"programme":8,"title":520,"piName":14,"institution":521,"country":134,"year":13,"amount":522,"abstract":523},"cordis-european-research-council-award-101142734","TURN-TAKING AND TURNING POINTS IN VIOLENT ENCOUNTERS. TOWARDS AN EXPLANATORY THEORY OF HOW CONFLICTS IN URBAN PUBLIC SPACE BEGIN, TRANSFORM AND END","UNIVERSITEIT LEIDEN","€2,499,744","Although violent police-civilian and civilian-civilian encounters constitute a tiny sliver of the social interactions that take place each day, their consequences can be far-reaching. Images of assailants committing bestial violence against vulnerable victims arouse public fear and indignation, while the excessive use of force by police undermines public trust, cooperation and the rule of law in democratic societies. Depicting such violence as senseless moreover obscures the fact that violent ac",{"id":525,"funder":7,"programme":8,"title":526,"piName":14,"institution":491,"country":134,"year":13,"amount":91,"abstract":527},"cordis-european-research-council-award-101142159","Precision Rayleigh jet sprays","Sprays have a wide range of applications, from cleaning to agriculture to medical treatments. Spray technologies are key to many industrial processes, yet many current spray technologies suffer from insufficient control over the resulting spray parameters, such as the droplet size distribution, even though the drop size critically determines whether a spray reaches its target or not in applications such as pharmaceutical drug inhalation and agricultural spraying. As trial-and-error spray develop",{"id":529,"funder":7,"programme":8,"title":530,"piName":14,"institution":491,"country":134,"year":13,"amount":91,"abstract":531},"cordis-european-research-council-award-101201482","Coherent Hypothesis Tests for Experimental Research","Across psychology and allied disciplines, the statistical analysis of experimental data hinges on a comprehensive set of frequentist techniques that culminate in confidence intervals and p-values. These frequentist analysis-of-variance (ANOVA) techniques form the fossilized core of what is taught, practiced, and expected. This proposal seeks to break the mould and develop a comprehensive set of alternative Bayesian techniques that are attractive, interpretable, practically feasible, and ultimate",{"id":533,"funder":7,"programme":8,"title":534,"piName":14,"institution":535,"country":79,"year":13,"amount":536,"abstract":537},"cordis-european-research-council-award-101141408","Roaming Ancestry – Landscapes of social and genetic relations in prehistory","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€2,496,811","Kinship systems and networks of contact and exchange in prehistoric societies could so far only be studied indirectly. Recent advances in archaeogenetics have enabled the retrieval of ancient genomic data with high success rates, which often allows the study of nearly all individuals from the same archaeological site, making intra-site studies become reality. Estimating degrees of biological relatedness and demonstrating biological unrelatedness can form a robust scaffold to reconstruct social a",{"id":539,"funder":7,"programme":8,"title":540,"piName":14,"institution":535,"country":79,"year":13,"amount":541,"abstract":542},"cordis-european-research-council-award-101201230","Galaxy Centers: Understanding Star Formation in Extreme Environments","€2,436,250","Gas-rich galaxy centers like our own Milky Way's Central Molecular Zone (CMZ) are amongst the most extreme, yet poorly understood, environments for star formation. These regions are affected by large-scale in- and out-flows of gas, by nuclear starburst and\u002For active galactic nuclei, which makes them unique laboratories in the local universe to study star formation at the highest gas and stellar mass densities, intense radiation fields, and short (\u003C50 Myr) dynamical timescales. CMZs are compact (",{"id":544,"funder":7,"programme":8,"title":545,"piName":14,"institution":535,"country":79,"year":13,"amount":546,"abstract":547},"cordis-european-research-council-award-101142396","Multi-messenger Studies of Extragalactic Super-colliders","€2,799,989","Active galactic nuclei (AGN) are among the most powerful particle accelerators in the Universe. They convert the gravitational energy of matter accreted by supermassive black holes (SMBHs) into electromagnetic and kinetic energy, producing highly relativistic electrons and protons. They are most likely originated from the vicinity of SMBHs, but the exact mechanism of their production remains elusive. Electrons are predominantly found in jets, whose acceleration and collimation are still poorly u",{"id":549,"funder":7,"programme":8,"title":550,"piName":14,"institution":551,"country":12,"year":13,"amount":552,"abstract":553},"cordis-european-research-council-award-101142840","Beyond Renormalization in Parabolic Dynamics","CY CERGY PARIS UNIVERSITE","€2,183,838","The ergodic theory of parabolic dynamical systems is an area in smooth ergodic theory that is relevant  for its connections to mathematical physics  and to analytic number theory.  A dynamical system is parabolic whenever its orbits diverge at an intermediate (often polynomial) rate between bounded\u002Flogarithmic (called elliptic) and exponential (called hyperbolic) rate.The proposal tackles several outstanding questions in the ergodic theory of parabolic flows with emphasis on quantitative aspects",{"id":555,"funder":7,"programme":8,"title":556,"piName":14,"institution":557,"country":128,"year":13,"amount":558,"abstract":559},"cordis-european-research-council-award-101200871","Antibody-guided design of multivalent nanoparticle vaccines against bacterial pathogens","LUNDS UNIVERSITET","€2,485,312","Vaccines are the most effective single measure to protect populations against infectious diseases without promoting antimicrobial resistance (AMR). In this proposal, I intend to harness the rapid developments in protein design and quantitative and structural mass spectrometry to i) enable detailed molecular characterization of circulating serum antibody repertories, ii) establish a generalizable framework for antibody-guided design of next-generation nanoparticle vaccines against bacteria and ii",{"id":561,"funder":7,"programme":8,"title":562,"piName":14,"institution":557,"country":128,"year":13,"amount":14,"abstract":563},"cordis-european-research-council-award-101199455","Incredible journeys: How do multiple sensory cues allow animal migrants to precisely navigate to a distant goal?","Many animals, including birds, sea turtles and insects, perform spectacular long-distance migrations across the Earth. Remarkably, some of these accurately migrate between highly specific places thousands of kilometres apart, a navigational feat that is barely understood. Such precision navigation requires global compass cues to guide their long journey, and local cues at the destination to signal their arrival. I have discovered that the migratory Australian Bogong moth, with a brain size a ten",{"id":565,"funder":7,"programme":8,"title":566,"piName":14,"institution":567,"country":134,"year":13,"amount":91,"abstract":568},"cordis-european-research-council-award-101140863","Spatial Metabolic Regulation in Kidney Repair","ACADEMISCH ZIEKENHUIS LEIDEN","Chronic kidney disease (CKD) is a global health concern, and the limited treatment options for end-stage kidney disease have remained unchanged for decades. Concurrent insults to the kidney can exacerbate disease progression, but the underlying potential to have kidney repair after such injury remains poorly understood. The tricarboxylic acid (TCA) cycle, a fundamental metabolic pathway, plays a vital role in energy production and biomolecule synthesis. Recent research by my group has revealed t",{"id":570,"funder":7,"programme":8,"title":571,"piName":14,"institution":572,"country":33,"year":13,"amount":573,"abstract":574},"cordis-european-research-council-award-101198755","Land use, Sustainability, and Democratic Backsliding","UNIVERSITE CATHOLIQUE DE LOUVAIN","€2,490,723","Land use and land systems, i.e. how human societies manage and interact with land through social-ecological systems, are at the core of sustainability issues. Democratic backsliding, i.e. the decline or degradation of theinstitutions and social norms that sustain democratic societies, is a widespread and impactful trend, with strong but understudied two-ways linkages with land use dynamics. In LUDEMO, we will make key contributions to understanding the linkages between these issues, with (i) exp",{"id":576,"funder":7,"programme":8,"title":577,"piName":14,"institution":578,"country":79,"year":13,"amount":579,"abstract":580},"cordis-european-research-council-award-101141396","Unraveling the Supramolecular Architecture of Molecular Machineries in Adaptive Immunity","JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN","€2,499,938","To combat daily threats of pathogens and abnormal cells, the human organism features a sophisticated defense mechanism called the adaptive immune system. In broad terms, this intricate mechanism is triggered by specific peptide epitopes presented on molecules of the major histocompatibility complex class I (MHC I), which are scanned by cytotoxic T cells. Intracellular transport, loading, and cell-surface recognition of antigenic peptides on MHC I are orchestrated by machineries, the peptide-load",{"id":582,"funder":7,"programme":8,"title":583,"piName":14,"institution":584,"country":140,"year":13,"amount":585,"abstract":586},"cordis-european-research-council-award-101200990","Predicting the Natural Future of Earth’s Climate","CARDIFF UNIVERSITY","€2,499,168","The future of Earth’s climate is of international concern. Yet the models we depend on for predicting the future remain uncalibrated against a natural baseline because that baseline has yet to be defined. In this ambitious project, we will generate the first empirically based predictions of a future climate that will constrain and define the natural baseline. Combined with state-of-the-art climate model experiments, this will allow us to deliver the first quantitative assessment of the absolute ",{"id":588,"funder":7,"programme":8,"title":589,"piName":14,"institution":590,"country":591,"year":13,"amount":91,"abstract":592},"cordis-european-research-council-award-101141357","Overcoming Mechanically-Induced Resistance to Chemo-Immunotherapy in Pancreatic Cancer","UNIVERSITY OF CYPRUS","CY","Cancer progression is closely associated with generation of mechanical stresses that cause the compression of tumor vessels, drastically reducing delivery of drugs. My co-workers and I found that host cells and extracellular matrix in tumors generate these stresses. Furthermore, we identified the anti-hypertensive losartan to alleviate intratumoral stresses and decompress vessels, allowing drugs to enter the tumor. My colleagues tested losartan in pancreatic cancer patients and found improved re",{"id":594,"funder":7,"programme":8,"title":595,"piName":14,"institution":596,"country":140,"year":13,"amount":597,"abstract":598},"cordis-european-research-council-award-101201424","A new look at the solar coronal heating problem","UNIVERSITY OF WARWICK","€2,483,461","The proposed project aims to transformatively advance our understanding of the enigmatic phenomenon of solar coronal heating. The ground-breaking nature of the proposed research is the anticipated revolutionary change of our understanding of basic physical mechanisms for the formation and evolution of the solar and stellar coronae. The key novel elements of the study are fresh and original hypotheses and methodologies. We hypothesise that a significant fraction of the energy released short-durat",{"id":600,"funder":7,"programme":8,"title":601,"piName":14,"institution":596,"country":140,"year":13,"amount":602,"abstract":603},"cordis-european-research-council-award-101200301","Generic regularity of area minimising hypersurfaces and mean curvature flows","€2,412,795","Major advances in geometry and topology have been achieved by studying critical points and gradient flows for natural energies, but these analytic methods are hindered when singularities occur. In fact, singularities are the main obstacle in the use of area minimisation in the proof of the positive mass theorem up to dimension 7 and the use of Ricci flow with surgery in the proof of the 3-dimensional Poincaré conjecture. A key observation in geometry and physics is that generic solutions, obtain",{"id":605,"funder":7,"programme":8,"title":606,"piName":14,"institution":596,"country":140,"year":13,"amount":607,"abstract":608},"cordis-european-research-council-award-101200245","Histories of Asia's Gendered Armed Frontiers, 1780 - 2021","€2,375,861","HAGAF will pioneer research in the comparative and transnational, colonial, and post-colonial history of protracted conflicts in the borderlands of Myanmar, India, and Bangladesh through a gendered lens. Referred to in HAGAF as the Indo-Burma borderlands, this historically marginalized, mountainous region was once central to the North East Frontier of British India and part of a global strategic defence system. Bringing together extensive but administratively separate colonial archives with fiel",{"id":610,"funder":7,"programme":8,"title":611,"piName":14,"institution":612,"country":26,"year":13,"amount":613,"abstract":614},"cordis-european-research-council-award-101199196","MOnitoring Symmetries with Entanglement","SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE","€2,404,715","Symmetry and entanglement stand as two foundational concepts in modern quantum physics that have revolutionised our understanding of quantum many-body systems. Their interplay is becoming a central theme in contemporary quantum research, influencing a broad spectrum of fields including quantum information, condensed matter theory, and high-energy physics.The MOSE project sets out to develop new theoretical frameworks to explore how entanglement and symmetries interact with each other. We will in",{"id":616,"funder":7,"programme":8,"title":617,"piName":14,"institution":618,"country":79,"year":13,"amount":619,"abstract":620},"cordis-european-research-council-award-101201061","Constructing the continuum-physics core of a digital twin for tribological contacts under boundary and mixed lubrication conditions","FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV","€2,453,946","A non-empirical continuum-physics-based digital twin for boundary and mixed lubricated tribosystems (the LubeTwin) would revolutionize the design and operation of sliding contacts in machines. Today, reliable continuum models of thermo-elasto-hydrodynamic lubrication (TEHL) are routinely used for component design. However, these standard TEHL models are considered to be invalid when the sliding surfaces are not separated by a thick enough lubricant film. My preliminary work suggests that TEHL ca",{"id":622,"funder":7,"programme":8,"title":623,"piName":14,"institution":624,"country":625,"year":13,"amount":626,"abstract":627},"cordis-european-research-council-award-101142033","Anger, Legitimised (ANGLE): Amplified anger and its rhetorics of legitimation in the 21st century","KOBENHAVNS UNIVERSITET","DK","€2,499,769","The world is an increasingly angry place. Fueled by economic turmoil, conflict, climate collapse and culture wars, outbursts of collective anger are visible online, on the streets, and in various political forums. These outpourings of visible, collective ire, what we call ‘amplified anger’, have been historically condemned in mainstream public discourse as anti-democratic, uncivil attacks on human co-existence. But for the people engaged in these acts of rage, anger is often seen as a fully legi",{"id":629,"funder":7,"programme":8,"title":630,"piName":14,"institution":631,"country":625,"year":13,"amount":632,"abstract":633},"cordis-european-research-council-award-101141953","Unpacking confined lives: Generating a global research agenda on the intersection of urban marginality, displacement, and incarceration","AALBORG UNIVERSITET","€2,480,541","CONFINED will develop and validate an innovative, comparative, and global research agenda of confined lives. Confinement is a ubiquitous and unequally distributed human condition. While confinement sometimes can be protective, for some groups, not least the displaced on dangerous roads, the marginalized in urban slums and the detained in prisons, it can be a damaging experience linked to violence and inequality. With an empirical point of departure in different contexts across the global north a",{"id":635,"funder":7,"programme":8,"title":636,"piName":14,"institution":637,"country":638,"year":13,"amount":639,"abstract":640},"cordis-european-research-council-award-101140713","ARCHITECTURES OF COAL AND MODERN EUROPE","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","IE","€2,496,951","After centuries coalmining is ending in Europe. Few will be sorry to say goodbye to an industry that epitomises the causes and effects of climate change. But while its environmental impact is now starkly and painfully obvious, Architectures of Coal and Modern Europe (ACME) explores another side of coalmining whose legacies and residues remain in various and often unexpectedly progressive forms. It argues that, responding to the unique conditions of coalmining – underground working practices, lab",{"id":642,"funder":7,"programme":8,"title":643,"piName":14,"institution":291,"country":292,"year":13,"amount":644,"abstract":645},"cordis-european-research-council-award-101199868","New era in dark matter phenomenology, the dawn of the nuclear clocks","€2,271,204","What is the  nature of dark matter (DM)? This central question in physics could be soon addressed thanks to the unprecedented sensitivity of nuclear clocks. These Th-229-base clocks are set to overcome the inherent limitations of atomic and molecular clocks, which are less sensitive to the nuclear parameters, which dominate almost all motivated models of ultralight DM (ULDM) . Laser excitation of Th-229 has just reached 1:10^11 sensitivity. Given that a precision of 1:10^8 suffices to probe DM-m",{"id":647,"funder":7,"programme":8,"title":648,"piName":14,"institution":649,"country":456,"year":13,"amount":91,"abstract":650},"cordis-european-research-council-award-101199807","Can tissue oxidation be sensed by positronium?","UNIWERSYTET JAGIELLONSKI","A method for non-invasive assessment of hypoxia (deficit of oxygen in tissue) is keenly awaited in medicine. This project is motivated by the exciting question whether it is possible to assess the concentration of oxygen in the tissue by detecting photons from positronium decays inside cells. Positronium (a bound state of an electron and positron) is copiously produced in the human body during positron emission tomography. Its properties in tissue depend on the size of the intramolecular voids a",{"id":652,"funder":7,"programme":8,"title":653,"piName":14,"institution":654,"country":140,"year":13,"amount":655,"abstract":656},"cordis-european-research-council-award-101200144","Synapse dynamics across sleep-wake states","UNIVERSITY COLLEGE LONDON","€3,492,265","Sleep is essential, yet its core functions and regulatory mechanisms are not fully understood. The synaptic homeostasis hypothesis suggests sleep helps normalize synapse strength and number accumulated during wakefulness. We have developed a zebrafish model for directly visualizing dynamic synaptic changes in single neurons across sleep\u002Fwake states. Our research indicates that synaptic changes in single neurons vary significantly across similar neuronal types under baseline conditions. Notably, ",{"id":658,"funder":7,"programme":8,"title":659,"piName":14,"institution":654,"country":140,"year":13,"amount":660,"abstract":661},"cordis-european-research-council-award-101198965","Citizen Attitudes Towards National and International Problems","€2,491,860","Political scientists have collected rich data for understanding the preferences of citizens regarding which policies their governments ought to enact, as well as for investigating where these preferences do and do not exist, and how they arise. In contrast, we have poor data and methods for understanding which problems citizens think are most severe and which government policy should be urgently addressing.  These questions of problems and priorities are difficult to investigate because they are",{"id":663,"funder":7,"programme":8,"title":664,"piName":14,"institution":665,"country":40,"year":13,"amount":91,"abstract":666},"cordis-european-research-council-award-101201790","Recapitulating the growth of the human heart to mature cardioids","INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH","Cardiovascular disease (CVD) is the leading global cause of death. Yet, breakthroughs in cardiac therapies are limited due to the poor predictive power of current models. While the animals fail to accurately replicate human heart physiology, the human pluripotent stem cell-derived models remain underdeveloped and immature for reliable disease modeling and therapy development. To address these challenges, we propose to further develop our cardiac organoid (“cardioid”) model and recapitulate the k",{"id":668,"funder":7,"programme":8,"title":669,"piName":14,"institution":230,"country":140,"year":13,"amount":670,"abstract":671},"cordis-european-research-council-award-101199785","Understanding Precancerous changes in BReast CAncer for the development of Therapeutic interceptions","€2,499,112","In this programme, we will leverage our understanding of the cellular and molecular changes that precede cancer in high-risk individuals to intercept and prevent the development of the disease. Despite significant advances in immune and targeted therapies, the molecular and cellular complexity of late-stage tumours continues to pose a major barrier to developing a definitive “cancer cure”. This underscores the urgency of identifying those at risk and intervening prophylactically to prevent tumou",{"id":673,"funder":7,"programme":8,"title":674,"piName":14,"institution":675,"country":79,"year":13,"amount":676,"abstract":677},"cordis-european-research-council-award-101199215","Multifunctional Flat Quantum Sources","FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG","€2,417,170","MultiFlaQS aims to develop efficient multifunctional sources of quantum light, namely entangled photon pairs and triplets, and squeezed states, based on ‘flat’ platforms, i.e., ultrathin layers and metasurfaces. The advantages of flat quantum sources (FlaQS) include: (i) small footprint and integrability; (ii) ultrabroadband and ultrafast operation; (iii) the possibility to combine several functionalities in the same device.Unlike linear and nonlinear ‘flat’ optics, which were developing for alm",{"id":679,"funder":7,"programme":8,"title":680,"piName":14,"institution":681,"country":128,"year":13,"amount":682,"abstract":683},"cordis-european-research-council-award-101200381","Cooper-pair spectroscopy: A new window into the world of superconductivity","KUNGLIGA TEKNISKA HOEGSKOLAN","€2,974,000","High temperature superconductivity and other unconventional types of superconductivity, such as topological superconductivity, are central topics in contemporary physics. At the heart of superconductivity lie the pairs of electrons, Cooper pairs, that are formed and condense into a superfluid state below a critical temperature Tc. An outstanding problem is the mechanism that underlies the electron-pairing in unconventional superconductors. Here this problem is addressed by developing a new exper",{"id":685,"funder":7,"programme":8,"title":686,"piName":14,"institution":687,"country":134,"year":13,"amount":688,"abstract":689},"cordis-european-research-council-award-101141740","Interactive phononic matter: reshaping crystal landscapes for ultrafast switching","STICHTING RADBOUD UNIVERSITEIT","€3,250,000","For almost two millennia people are looking for the philosophers' stone, dreaming to be able to change material properties at will. While turning lead to gold might just have become a reality, even though only a few atoms at a time, in a broader sense we are still very far from this. To make this dream come true, INTERPHON challenges the existing ideas and understanding of the interactions between light and matter, developing a research area at the junction of nonlinear optics, phononics and ult",{"id":691,"funder":7,"programme":8,"title":692,"piName":14,"institution":687,"country":134,"year":13,"amount":693,"abstract":694},"cordis-european-research-council-award-101141163","Quantum Control of Ultracold Molecules By Electric Fields","€3,352,573","The study of molecular collisions at the lowest possible energy has emerged as an exciting research frontier. At low energies the wave-character of matter leads to exotic scattering phenomena that reveal the fundamental mechanisms of molecular collisions. Crossed beam methods are ideal to probe collisions with the highest detail, but the lowest energy currently achievable is not sufficient to fully harvest these possibilities. Building upon my recent breakthrough in state-to-state merged beam sc",{"id":696,"funder":7,"programme":8,"title":697,"piName":14,"institution":675,"country":79,"year":13,"amount":698,"abstract":699},"cordis-european-research-council-award-101201269","Main Group Metals in Oxidation State Zero for Bond Activation and Catalysis","€2,499,856","Historically, main group metal organometallics are used as stoichiometric reagents in organic synthesis. This holds especially for highly polar s-block metal compounds like BuLi or Grignard’s. Only since the start of this century, it has been recognized that they also make for remarkably versatile catalysts. Parallel to these developments, the low-oxidation-state chemistry of the early main group metals emerged with the seminal isolation of first MgI complexes. Since 2007 numerous examples have ",{"id":701,"funder":7,"programme":8,"title":702,"piName":14,"institution":703,"country":134,"year":13,"amount":91,"abstract":704},"cordis-european-research-council-award-101201819","The Dance of Molecules:  Rhythmic Systems through Organic Catalysis","RIJKSUNIVERSITEIT GRONINGEN","Inspired by natural oscillatory systems that govern countless processes, from circadian rhythms to cellular metabolism, and the essential role of catalysis in both bio- and synthetic chemistry, this project aims to systematically design and construct modular, tunable organic chemical oscillators with catalytic functions. These oscillators will not only serve as time-keeping systems but also autonomously control and catalyze additional chemical reactions. The Belousov-Zhabotinsky reaction demonst",{"id":706,"funder":7,"programme":8,"title":707,"piName":14,"institution":708,"country":140,"year":13,"amount":91,"abstract":709},"cordis-european-research-council-award-101198896","Precision Synthesis and Catalysis using Solid-State Molecular Organometallic Chemistry. Single-Crystal Reactivity in 3D and 2D","UNIVERSITY OF YORK","Fast and efficient solution-based homogeneous catalysis, or the synthesis of complexes with weakly bound ligands (e.g. methane), often requires the formation of a highly active, coordinatively unsaturated, metal centre. However, the vast excess of solvent can play a detrimental role by competitive coordination, or reaction itself, at the metal centre. Even if solvent does not impede the formation of reactive species, dimerisation can form inactive complexes. These factors quench reactivity and o",{"id":711,"funder":7,"programme":8,"title":712,"piName":14,"institution":224,"country":33,"year":13,"amount":713,"abstract":714},"cordis-european-research-council-award-101201153","Get track of time for all events from the nano- to the crystal particle level in nanoporous materials","€2,498,875","This proposal aims to get track of time for all events taking place when guest molecules are sent over a crystal particle of a nanoporous material, as is occurring during catalysis, separation, sensing.The observation: When a feed of molecules is sent over a crystalline nanoporous framework following events take place: first the molecules need to enter the crystal, then travel through the material to find interesting sites where they adsorb\u002Fdesorb or react and eventually products leave the cryst",{"id":716,"funder":7,"programme":8,"title":717,"piName":14,"institution":718,"country":292,"year":13,"amount":719,"abstract":720},"cordis-european-research-council-award-101199841","Enzyme Mimicking by Metabolite-Metal Nanozymes with Exceptional Operational Stability","TEL AVIV UNIVERSITY","€2,776,000","While enzymes are highly useful in various applications, their limited operational stability and production costs have led to an extensive search for stable catalytic agents that will retain the efficiency, specificity, and environmental-friendliness of natural enzymes. Despite extensive efforts, there is still an unmet need for improved enzyme mimics and novel concepts to discover and optimize such agents. Inspired by the catalytic activity of amyloids and the formation of amyloid-like assembli",{"id":722,"funder":7,"programme":8,"title":723,"piName":14,"institution":473,"country":40,"year":13,"amount":724,"abstract":725},"cordis-european-research-council-award-101142915","Carbon-Hydrogen bond activation via  a new charge control approach","€2,750,000","Organic synthesis stands as the beating heart of technological and societal advancement, driving breakthroughs in drug discovery, agrochemistry, materials design, and the pursuit of a more sustainable world. In a world where C–H bonds are the main functional groups available, the field of C–H functionalisation has experienced exponential growth over the past two decades. While state-of-the-art methods have led to remarkable achievements, they remain confined by the dominance of substrate-control",{"id":727,"funder":7,"programme":8,"title":728,"piName":14,"institution":729,"country":625,"year":13,"amount":91,"abstract":730},"cordis-european-research-council-award-101142230","EPIGENETIC MEMORY BY COMMUNICATION ACROSS CHROMOSOME SCALES","KRAEFTENS BEKAEMPELSE","The ability of cells to specialize and maintain their identity through multiple cell divisions is critical for development, tissue renewal and diseases avoidance. A key frontier is therefore to understand how genome organization and function is inherited to daughter cells. EPICHS targets a new paradigm for how epigenetic information is propagated, in which communication between the 2D epigenome and 3D genome organization maintains cellular identity. Inheritance of epigenetic states involves the ",{"id":732,"funder":7,"programme":8,"title":733,"piName":14,"institution":291,"country":292,"year":13,"amount":734,"abstract":735},"cordis-european-research-council-award-101200530","New approaches for the analysis and utilization of wheat genetic diversity","€2,498,500","Addressing the challenge of food security during the current environmental crisis will necessitate rapidly breeding a new generation of adapted cultivars. Genetic diversity and selection of natural variants are key to advances in breeding. However, there is a need for better tools to predict how natural variation impacts plant performances, to improve the precision and efficiency of gene modification, and transfer from wild relatives to crops. We will focus on wheat, one of the most important st",{"id":737,"funder":7,"programme":8,"title":738,"piName":14,"institution":739,"country":176,"year":13,"amount":740,"abstract":741},"cordis-european-research-council-award-101140624","How dividing cells adapt to karyotypic evolution","I3S - INSTITUTO DE INVESTIGACAO E INOVACAO EM SAUDE DA UNIVERSIDADE DO PORTO","€2,955,225","Alterations in chromosome number and size are hallmarks of cancer, and yet they are also crucial for species evolution. Recent insight on chromosome structure and segregation, together with significant advances in genomic sequencing, established previously underappreciated parallels between the mechanisms of karyotypic evolution during speciation and cancer. Importantly, alterations in chromosome number and size pose significant challenges for the cell division machinery. However, how dividing c",{"id":743,"funder":7,"programme":8,"title":744,"piName":14,"institution":349,"country":79,"year":13,"amount":745,"abstract":746},"cordis-european-research-council-award-101199896","Scalable and Sustainable Sorting and Processing of Semiconducting Carbon Nanotubes as Functional Materials","€2,496,473","Single-walled carbon nanotubes (SWNTs) feature outstanding electronic (high carrier mobilities) and optical (narrow near-infrared absorption and emission) properties. To harness these properties for functional materials and devices, they must be separated into purely semiconducting, metallic or even single-chirality SWNTs. The currently available separation methods are either expensive, not scalable or require harmful chemicals and solvents. Likewise, the subsequent processing of SWNTs into opti",{"id":748,"funder":7,"programme":8,"title":749,"piName":14,"institution":624,"country":625,"year":13,"amount":750,"abstract":751},"cordis-european-research-council-award-101201676","Sensing of cytoplasmic double-stranded RNA in plants","€2,475,596","Elimination of foreign nucleic acids is key to host survival and reproduction. Long double-stranded RNA (dsRNA) in the cytoplasm is used to distinguish viral from host genetic material, and several metazoan dsRNA receptors elicit innate immune responses upon binding to dsRNA. Plants are thought to rely exclusively on RNA interference (RNAi) to eliminate RNA with double-stranded features. Two DICER-LIKE (DCL) enzymes, DCL4 and DCL2, act redundantly to cleave dsRNA into small interfering RNAs that",{"id":753,"funder":7,"programme":8,"title":754,"piName":14,"institution":755,"country":128,"year":13,"amount":91,"abstract":756},"cordis-european-research-council-award-101201464","Mechanism of Sugar Transporters involved in Human Health and Disease","STOCKHOLMS UNIVERSITET","From molds to mammals, glucose is the most important fuel for life on earth. The rate-limiting step for the utilization of glucose is its uptake into cells. Mammals have fourteen different sugar transporters belonging to the SLC2A family, referred to as GLUTs. GLUT1-14 transporters have varied tissue expression and kinetics, and their activities must be synchronized and regulated for the appropriate whole-organism-wide distribution of glucose and other sugars. Even at the most basic level, we st",{"id":758,"funder":7,"programme":8,"title":759,"piName":14,"institution":257,"country":134,"year":13,"amount":190,"abstract":760},"cordis-european-research-council-award-101200111","Directing Stem Cell Activity through Mechanical Stimulation of Metamaterial 3D Scaffolds","Regenerative medicine aims at repairing damaged tissues in our body. To do so, stem cells are often used. My research has been focused on biofabrication innovations for tissue engineering, which aims to direct stem cell fate to steer tissue regeneration. While mechanical loading play a determinant role in the organization of adult cells and tissue development, and my past work with 3D scaffolds demonstrated the importance of mechanical cues to direct stem cell fate, very little is known about it",{"id":762,"funder":7,"programme":8,"title":763,"piName":14,"institution":764,"country":140,"year":13,"amount":765,"abstract":766},"cordis-european-research-council-award-101201307","The Trouble with Gender","KING'S COLLEGE LONDON","€2,499,909","Fifty years after the term ‘gender’ entered the vocabulary of social scientists, intense contestation about its meaning has broken out, spilling out of the academy into noisy, heated and wounding spats on social media. As the ‘gender wars’ rage, splintering the consensus that once held together feminist engagement in international policy arenas and international development on 'gender equality', TROUBGEN asks: what’s happened, why now and what can be done? TROUBGEN will draw on the PI’s extensiv",{"id":768,"funder":7,"programme":8,"title":769,"piName":14,"institution":462,"country":33,"year":13,"amount":770,"abstract":771},"cordis-european-research-council-award-101200916","Connecting Joint Function to Chondrocyte Biology in Knee Osteoarthritis","€3,283,437","Osteoarthritis (OA), a degenerative joint disease, debilitates the lives of 242 million people globally but remains without a cure.The knee joint is most frequently affected, causing pain, loss of joint function, and reduced quality of life. OA-CONNECTinstigates an innovative approach to understanding the fundamental cause of OA by posing a question that could previouslynever be answered: ‘What causes mechanical loads to switch from supporting to disrupting cartilage health in OA?’OA-CONNECT int",{"id":773,"funder":7,"programme":8,"title":774,"piName":14,"institution":775,"country":134,"year":13,"amount":91,"abstract":776},"cordis-european-research-council-award-101141998","Real-time Multiscale Imaging of Pathological Calcification - Zooming in on Aortic Valve Calcification","STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM","Calcifying Aortic Valve Disease (CAVD) is a cellular-driven disease that actively alters the structure and composition of the valve extracellular matrix, leading to severe disfunction of the heart. Because the molecular mechanisms underlying CAVD are still unknown, there are currently no drug-based therapies and valve replacement is the only available treatment.Specifically, it is still unknown (1) how the disease modifies the extracellular matrix (ECM) to become susceptible for mineralization, ",{"id":778,"funder":7,"programme":8,"title":779,"piName":14,"institution":578,"country":79,"year":13,"amount":780,"abstract":781},"cordis-european-research-council-award-101141762","Phase, time and correlations in free electron wave packets","€2,457,443","Electron emission from matter is a widespread phenomenon in nature, with examples including the photoionization of atoms and molecules, photoemission from solids, and the release of electrons due to ionizing radiation in biology. Complete information about the emitted electrons is contained in the amplitude and phase of their wave packets. While state-of-the-art electron spectroscopy routinely accesses the amplitude of these wave packets, the phase of free electron wave packets remains inaccessi",{"id":783,"funder":7,"programme":8,"title":784,"piName":14,"institution":96,"country":97,"year":13,"amount":785,"abstract":786},"cordis-european-research-council-award-101142364","Realizing designer quantum matter in van der Waals heterostructures","€2,498,623","Conventional materials hosting exotic quantum phases typically have complex atomic structures, inhomogeneities from defects, impurities, and dopants making it difficult to rationally engineer their electronic properties. This can be overcome using van der Waals (vdW) heterostructures that allow an almost arbitrary selection of the heterostructure building blocks, including metals and insulators, charge-density wave systems, superconductors, magnets, correlated insulators, and ferroelectrics. In ",{"id":788,"funder":7,"programme":8,"title":789,"piName":14,"institution":624,"country":625,"year":13,"amount":91,"abstract":790},"cordis-european-research-council-award-101141278","Green Surveillance: Imagining a Sustainable Internet of Things","The emerging Internet of Things (IoT) constitutes a communication system that enables comprehensive and continuous monitoring of the effects of human activity on Earth’s ecosystems, thus potentially facilitating the green transition to sustainable forms of social life. But the scope and the scale of the necessary monitoring simultaneously entails surveillance, not only of natural and built environments, but of persons and their actions as well, extending far beyond the online tracking of citizen",{"id":792,"funder":7,"programme":8,"title":793,"piName":14,"institution":794,"country":134,"year":13,"amount":91,"abstract":795},"cordis-european-research-council-award-101141457","REVisiting Antibody structures and repertoires through advances in  Mass spectrometry and Proteomics","UNIVERSITEIT UTRECHT","In REVAMP, I will create innovative structural mass spectrometry (MS) and proteomics techniques to generate an unprecedented molecular understanding of the diversity and structural and functional characteristics of human antibody repertoires. These repertoires are highly personal and play a key role in our human immune response.Recently, my research has taken a novel challenging avenue, with a focus on the development of cutting-edge MS-based techniques to better understand antibody structure an",{"id":797,"funder":7,"programme":8,"title":798,"piName":14,"institution":799,"country":79,"year":13,"amount":91,"abstract":800},"cordis-european-research-council-award-101201386","Visual Translatomics – Deep ribosomal insights by cryo-electron microscopy of actively translating ribosomes","CHARITE - UNIVERSITAETSMEDIZIN BERLIN","Structure determination of dynamic macromolecular molecular machines and elucidating their conformational landscapes are fundamental tasks of structural biology. The ribosome as a paradigmatic macromolecular machine interacts with numerous ligands and factors throughout its functional cycles, which in turn are driven and regulated by various conformational modes. Project DeepRibosome proposes a new way to perform structural studies. It is based on our recent finding that E. coli ex-vivo derived ",{"id":802,"funder":7,"programme":8,"title":803,"piName":14,"institution":804,"country":140,"year":13,"amount":805,"abstract":806},"cordis-european-research-council-award-101199255","KNOW-HOW: A new framework for theoretical and practical control across intelligence domains","UNIVERSITY OF GLASGOW","€2,480,625","Knowing what is true is valuable, but practical knowledge – knowledge how to do things – is equally critical. Having such ‘know-how’ enables us to succeed in action, and achieve our goals. Currently, little consensus exists across philosophical and empirical disciplines about the nature of know-how and what is involved in exercising it. Research results are siloed across epistemology, action theory, philosophy of language, and cognitive science, and fundamental disagreement persists about whethe",{"id":808,"funder":7,"programme":8,"title":809,"piName":14,"institution":291,"country":292,"year":13,"amount":91,"abstract":810},"cordis-european-research-council-award-101198168","Exploring the dynamics of the gastrointestinal tract using shed cell and spatial transcriptomics","The gastrointestinal (GI) tract undergoes significant changes during post-natal development and in response to various diseases. Single-cell atlases are static and therefore fail to capture the dynamic changes occurring within the GI tract. We have devised a method to transcriptomically profile cells that are naturally shed into the GI tract. Contrary to earlier beliefs, we found that shed cells remain viable and can robustly be measured in fecal samples. Shed cell transcriptomics enables non-in",{"id":812,"funder":7,"programme":8,"title":813,"piName":14,"institution":411,"country":110,"year":13,"amount":814,"abstract":815},"cordis-european-research-council-award-101198761","Cell-Cell Communication by Mitochondrial Intercellular Traffic","€2,455,167","Mitochondrial research has consistently yielded surprising discoveries, such as the presence of their own DNA, use of a distinct genetic code, and their role in apoptosis. Recently, the proposal of intracellular mitochondrial transfer (ICMT) in vivo has sparked considerable interest, as this process is believed to hold significant therapeutic potential. This has generated growing public and private economical and scientific effort aimed at exploring ICMT as a potential treatment for common and r",{"id":817,"funder":7,"programme":8,"title":818,"piName":14,"institution":224,"country":33,"year":13,"amount":91,"abstract":819},"cordis-european-research-council-award-101200711","Tumor acidosis targeted delivery of immunotherapy by Marker-Agnostic TumoR-Anchoring Chimeras","Cancer immunotherapy represents a groundbreaking advancement in oncology, leveraging the immune system to combat malignancies with enhanced specificity and reduced systemic toxicity compared to traditional therapies. However, despite significant progress, current immunotherapies face limitations, particularly in targCancer immunotherapy represents a groundbreaking advancement in oncology, leveraging the immune system to combat malignancies with enhanced specificity and reduced systemic toxicity ",{"id":821,"funder":7,"programme":8,"title":822,"piName":14,"institution":491,"country":134,"year":13,"amount":91,"abstract":823},"cordis-european-research-council-award-101142006","Governance by data infrastructure in the post-pandemic democracy","Facial recognition cameras, digital identity systems, and health dashboards have become a staple of daily life. By generating data aimed at monitoring or decision-making, these “regulatory data infrastructures” take up functions that were once performed by humans inside state entities and public administrations. Regulatory data infrastructures are at the core of a new mode of governance normalized in the post-pandemic society, termed “governance by data infrastructure”. With the pandemic and gen",{"id":825,"funder":7,"programme":8,"title":826,"piName":14,"institution":827,"country":79,"year":13,"amount":828,"abstract":829},"cordis-european-research-council-award-101140770","Catalytic Light-induced Deracemization","TECHNISCHE UNIVERSITAET MUENCHEN","€2,447,299","Molecules are chiral if they exist in two forms, called enantiomers, which behave like image and mirror image. In many applications, e.g. in medicine, nutrition, and crop protection, chiral molecules are required as a single enantiomer (enantiomerically pure compound) but not as a mixture (racemate). The market for enantiomerically pure compounds exceeds 100 billion  annually and continues to grow rapidly. Despite significant recent advances in asymmetric catalysis, many chiral compounds are for",{"id":831,"funder":7,"programme":8,"title":832,"piName":14,"institution":833,"country":625,"year":13,"amount":834,"abstract":835},"cordis-european-research-council-award-101201783","RNA Origami Technology in Cell Systems","AARHUS UNIVERSITET","€2,829,725","Biomolecular nanotechnology aims at using the self-assembly principles of nature to create nanostructures and nanomachines for applications in biotechnology, medicine, and materials science. Advanced nanodevices, that sense inputs, do basic computations, and actuate functionality or movement within their nanoscale environment, are referred to as “nanorobots”. With advances in methods for prediction and design of RNA and protein structure, there is now a big opportunity to create complex biomolec",{"id":837,"funder":7,"programme":8,"title":838,"piName":14,"institution":833,"country":625,"year":13,"amount":839,"abstract":840},"cordis-european-research-council-award-101200092","FILTERING FUTURES: CONTAMINANT FLOWS, LANDSCAPE GOVERNANCE AND THE MAKING OF NEW ANTHROPOLOGICAL KNOWLEDGE FOR PLANETARY HEALTH","€2,317,071","Filtering contaminating flows in water ecologies is a critical problem for planetary health. Current approaches e.g. One Health, favour collaboration among disciplines, governmental bodies, citizens and ecological (more-than-human) actors, to innovate new thinking and sustain interventions. Despite aspirations, efforts to pull human and ecological forces into play remain obstructed by disciplinary silos, vested interests, epistemic uncertainty and a lack of a shared vocabulary.  FILTERSCAPE offe",{"id":842,"funder":7,"programme":8,"title":843,"piName":14,"institution":844,"country":26,"year":13,"amount":845,"abstract":846},"cordis-european-research-council-award-101201268","CONNECTING VOLTAGE-GATED POTASSIUM CHANNELS TO TRANSCRIPTIONAL AND TRANSLATIONAL REGULATION","UNIVERSITA DEGLI STUDI DI PADOVA","€2,949,476","Potassium (K+) channels are found in the majority of cells in almost every organism, where they regulate a wide variety of physiological functions in response to environmental stimuli. The goal of TRANSION is to confirm our hypothesis that physical coupling between voltage-gated potassium (K+) channels in the Shaker-type (Kv1) family and specific transcription factors (TFs) provides a widespread signaling checkpoint that coordinates information from different stimuli and orchestrates appropriate",{"id":848,"funder":7,"programme":8,"title":849,"piName":14,"institution":230,"country":140,"year":13,"amount":850,"abstract":851},"cordis-european-research-council-award-101199727","Human and avian Pattern Recognition Receptor activation of cell death pathways: impact on the host inflammatory response to zoonotic infections.","€2,498,468","Zoonotic infections, particularly with viruses or bacteria, continue to be important threats to humans globally. These infections can cause severe inflammatory disease in humans, but may be tolerated by their animal hosts although how this occurs is unclear. Many human diseases have underlying inflammatory aetiologies so determining how diversity in host-pathogen responses occurs across animal species provides unique opportunities not only to identify fundamental inflammatory mechanisms, but als",{"id":853,"funder":7,"programme":8,"title":854,"piName":14,"institution":146,"country":134,"year":13,"amount":91,"abstract":855},"cordis-european-research-council-award-101141674","In vivo Immunofluorescence-Optical Coherence Tomography","Current clinical medicine relies on MRI and CT for structural imaging, and immuno-PET\u002FSPECT for molecular specificity. The combination of structural imaging and molecular specific imaging provides detailed information about expression of proteins and cell surface receptors in vivo in humans. PET-CT\u002FMRI has become an essential component of personalized medicine. However, the resolution of MRI\u002FCT is just under a millimeter, while the resolution of PET is limited to about 2-10 millimeters, insuffic",{"id":857,"funder":7,"programme":8,"title":858,"piName":14,"institution":859,"country":40,"year":13,"amount":860,"abstract":861},"cordis-european-research-council-award-101201517","Targeting neutrophils in colorectal cancer","MEDIZINISCHE UNIVERSITAT INNSBRUCK","€2,496,900","Colorectal cancer (CRC) is the second most common cause of cancer death with an alarming rising incidence among young individuals. While the management of early-stage CRC has improved greatly, the median overall survival for patients with metastatic CRC is 30 months. Immune checkpoint inhibitors (ICI) have revolutionized the treatment of advanced solid cancers, yet for CRC continue to lag behind, with the exception of 4% of patients with microsatellite instability. In contrast, several studies h",{"id":863,"funder":7,"programme":8,"title":864,"piName":14,"institution":865,"country":12,"year":13,"amount":866,"abstract":867},"cordis-european-research-council-award-101142018","Engineering soft microdevices for the mechanical characterization and stimulation of microtissues","ECOLE POLYTECHNIQUE","€3,475,660","As living beings move, touch, or grow, the tissues within them are subject to mechanical stresses that act over minutes, hours, or days. These efforts play a critical role at all stages of life, from early embryonic development to homeostasis in adult tissues or disease progression. Mechanobiology has emerged in response to this realization and has led to many discoveries on mechanosensitive pathways in individual cells. However we are still very far from relating the single-cell behavior to the",{"id":869,"funder":7,"programme":8,"title":870,"piName":14,"institution":291,"country":292,"year":13,"amount":871,"abstract":872},"cordis-european-research-council-award-101200195","Deciphering Split Monopoiesis Impact on Tissue Macrophages","€2,499,990","Macrophages are key players in organ development, tissue maintenance, and the immune defense of vertebrate organisms. These cells are initially established during embryonic development, but most tissue-resident macrophage compartments are progressively seeded and often even replaced by monocyte-derived cells. Monocytes and their macrophage progeny critically contribute to a wide range of pathologies, including autoinflammatory, cardiovascular, and metabolic disorders, as well as cancer. Given th",{"id":874,"funder":7,"programme":8,"title":875,"piName":14,"institution":876,"country":79,"year":13,"amount":877,"abstract":878},"cordis-european-research-council-award-101140447","(Re-)Writing the Ubiquitin Code – Manipulating Polyubiquitin Chain Linkage to Investigate Ubiquitin Signalling in Genome Maintenance and Beyond","INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH","€2,499,799","Ubiquitylation is an essential posttranslational modification that governs the activities and interactions of cellular proteins. The structural diversity of polyubiquitin chains, collectively called the ubiquitin code, is thought to determine the fate of the modified proteins. Although many analytical and inhibitory ubiquitin-specific reagents exist, we lack the tools to create polyubiquitin chains of defined linkage on a protein of interest in cells to investigate their signalling functions. We",{"id":880,"funder":7,"programme":8,"title":881,"piName":14,"institution":535,"country":79,"year":13,"amount":91,"abstract":882},"cordis-european-research-council-award-101142538","Deconstructing Hypothalamic Neurocircuitry Architecture and Function in Metabolic Control during Health and Disease","Understanding the exact nature of CNS-dependent regulation of body weight has become of utmost societal importance as we are witnessing an ever-increasing number of overweight and obese subjects who exhibit a predisposition for a plethora of obesity-associated diseases such as type 2 diabetes mellitus, cardiovascular diseases, and certain types of cancers. However, despite the tremendous advances made in defining the neurocircuitry basis underlying the central control of feeding and metabolism, ",{"id":884,"funder":7,"programme":8,"title":885,"piName":14,"institution":799,"country":79,"year":13,"amount":886,"abstract":887},"cordis-european-research-council-award-101142121","Function of Cholangiocytes in chronic liver diseases","€2,499,289","Cholangiocytes are the mCholangiocytes are the main cell type lining the epithelium of the biliary tree, a network of conduits which drain the liver from bile produced by hepatocytes. While the role of cholangiocytes have been broadly studied in the context of cholangiopathies, their role in chronic liver disease affecting hepatocytes is often overlooked despite growing evidence that they play a central role in disease progression, regeneration, and cancer. Thus, understanding the mechanisms con",{"id":889,"funder":7,"programme":8,"title":890,"piName":14,"institution":891,"country":79,"year":13,"amount":91,"abstract":892},"cordis-european-research-council-award-101141579","Cellular Strategies of Protein Quality Control-Degradation","UNIVERSITAT ZU KOLN","Maintaining the quality of all proteins in an organism is fundamental to life since it ensures tissue function, organismal health, and longevity. Protein quality control (PQC) is achieved by selective degradation of damaged proteins, limiting the formation of protein aggregates and neurodegeneration characteristic of Alzheimers, Huntingtons, and Parkinsons disorders. Important regulators of cellular proteolysis are E3 ubiquitin ligases that target damaged proteins for degradation. However, thera",{"id":894,"funder":7,"programme":8,"title":895,"piName":14,"institution":291,"country":292,"year":13,"amount":896,"abstract":897},"cordis-european-research-council-award-101200719","Unleashing the power of steady-state high-resolution NMR: Methods, Molecules, Metabolism","€2,498,142","Pulsed Fourier-transform (FT) has reigned supreme in nuclear magnetic resonance (NMR) for over 50 years, standing at the core of numerous analytical, pharmaceutical, materials, biophysical and medical applications. However, if spectral information is not a must, FT NMR is not necessarily the optimal way for maximizing sensitivity: when, as often happens, spin relaxation times are long and T1≈T2, steady-state free-precession (SSFP) experiments can provide a higher sensitivity per unit time.  SSFP",{"id":899,"funder":7,"programme":8,"title":900,"piName":14,"institution":901,"country":140,"year":13,"amount":902,"abstract":903},"cordis-european-research-council-award-101201550","Co-morbidity and co-infection dynamicCo-morbidity and co-infection dynamic modelling to optimize the control of neglected tropical diseases, tuberculosis, malaria and HIV across vulnerable populations","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€2,497,921","Infections are a leading cause of mortality and morbidity. Among these, tuberculosis (TB), malaria, HIV\u002FAIDS and Neglected Tropical Diseases (NTDs) are the main contributors to the global burden of disease, particularly in Sub-Saharan Africa, where these chronic infections predominantly affect impoverished communities. Despite increasing evidence that these diseases affect the same populations and that interactions between them impact disease transmission and control, the complex, non-linear dyn",{"id":905,"funder":7,"programme":8,"title":906,"piName":14,"institution":901,"country":140,"year":13,"amount":91,"abstract":907},"cordis-european-research-council-award-101200375","Deconvoluting Signaling Activities of Mitochondrial-derived Reactive Metabolites with Unparalleled Depth and Spatiotemporal Precision","Mitochondria-derived reactive metabolites (mt-REMs) drive context-specific immunomodulatory behaviors during metabolic reprogramming. Yet, no method can interrogate the cause-and-effects of individual mt-REMs with locale specificity and temporal resolution. Mapping mt-REM-directed signaling changes with spatiotemporal resolution would thus be transformational.  I will develop a spatiotemporally-resolved in-vivo mt-REM-responsivity-mapping technology. This cross-disciplinary innovation will enabl",{"id":909,"funder":7,"programme":8,"title":910,"piName":14,"institution":901,"country":140,"year":13,"amount":911,"abstract":912},"cordis-european-research-council-award-101198904","Dimensionality of the human phenome","€2,499,733","What am I going to do?I will use data from millions of human genomes and thousands of traits (the “phenome”) to quantify the dimension of the heritable human phenome and dissect and map it to single DNA variant resolution; use whole genome sequence data in populations and families to estimate mutational trait heritability; predict future phenotypes using millions of DNA variants and thousands of environmental factors.Why am I going to do this?Despite the discovery of hundreds of thousands of DNA",{"id":914,"funder":7,"programme":8,"title":915,"piName":14,"institution":916,"country":26,"year":13,"amount":917,"abstract":918},"cordis-european-research-council-award-101198778","Boosting predictive concepts on arrhythmogenesis resolving and unifying cardiac electrophysiology and structural remodelling at organ-level","CONSIGLIO NAZIONALE DELLE RICERCHE","€2,646,938","Remodelling processes associated with genetic and non-genetic cardiac diseases can cause electrical conduction disturbances and arrhythmias. Current models used to predict functional alterations due to structural remodelling fail to accurately assess arrhythmogenic risk, mainly because they do not draw upon comprehensive functional and structural data and are typically based on low-resolution and non-integrated information. Here, I present HeartCORE, an interdisciplinary approach designed to est",{"id":920,"funder":7,"programme":8,"title":921,"piName":14,"institution":922,"country":12,"year":13,"amount":923,"abstract":924},"cordis-european-research-council-award-101141783","Maintenance of platelet homeostasis by tyrosine phosphatases and vascular heparan sulfates","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","€2,519,500","Platelets are highly reactive fragments of megakaryocytes (MKs) that have been implicated in all major pathophysiological processes, but the molecular mechanisms controlling the number and reactivity of platelets in the circulation remain incompletely defined. The prevailing thinking is that mechanical forces are the primary drivers of platelet production, but the logic is flawed and the evidence contradictory. What is glaringly overlooked are intrinsic inhibitory mechanisms and extrinsic cues p",{"id":926,"funder":7,"programme":8,"title":927,"piName":14,"institution":928,"country":110,"year":13,"amount":929,"abstract":930},"cordis-european-research-council-award-101198091","Unveiling oceanic bacterivory through gene expression","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","€2,498,215","Oceanic bacterivory is the process through which marine bacteria are grazed by microbial eukaryotes. It consumes a large fraction of bacterial production, transfers bacterial biomass to upper trophic levels, and completes the inorganic nutrient recycling needed for regenerated primary production. Global estimates indicate that ~15% of the Earth's primary production circulates through this process. Despite its central role in marine food webs, the identity of the dominant grazers is not well know",{"id":932,"funder":7,"programme":8,"title":933,"piName":14,"institution":827,"country":79,"year":13,"amount":934,"abstract":935},"cordis-european-research-council-award-101141712","Evaluating and Programming Intelligent Chatbots for Any Language","€2,498,200","Intelligent chatbots (ICs) such as ChatGPT have revolutionized the generation of content for a few languages such as English, but there are 7099 currently spoken languages in the world. EPICAL will, for the first time, determine how to add new low resource languages (LRLs) to ICs.  We will make six advances to revolutionize the capabilities of ICs, unifying different areas of research that are incorrectly studied separately. We will: 1) determine how to generate hallucination-free text using ICs",{"id":937,"funder":7,"programme":8,"title":938,"piName":14,"institution":922,"country":12,"year":13,"amount":939,"abstract":940},"cordis-european-research-council-award-101200669","Non-invasive recording of deep brain activity:  mobile sensors optimized with intracerebral measures","€2,670,692","Epilepsy presurgical evaluation consists in mapping the brain regions generating pathological activities, which can be surgically resected. The current method of choice is stereotaxic electroencephalography (SEEG), an invasive procedure which involves implanting  a limited number of electrodes in the brain. Thanks to 4-He Optically Pumped Magnetometers (OPMs), a new generation of mobile sensors, I will be able to record magnetic activity non-invasively across the whole brain. Compared to classic",{"id":942,"funder":7,"programme":8,"title":943,"piName":14,"institution":922,"country":12,"year":13,"amount":91,"abstract":944},"cordis-european-research-council-award-101142153","Active Inference and the Circuits of Precision and Prediction","The human brain exhibits remarkable cognitive abilities, such as imagery, attention and mental simulation, which along with perception reflect our capacity to infer properties of the world. Perceptual inference involves a statistical hierarchical synthesis of information from the senses with prior knowledge of the world. There is empirical evidence in favour of Predictive Processing where functional interaction of descending pathways carrying top-down prediction and precision signals interaction",{"id":946,"funder":7,"programme":8,"title":947,"piName":14,"institution":948,"country":12,"year":13,"amount":949,"abstract":950},"cordis-european-research-council-award-101141778","Linguistic Texts of Roman Antiquity. Collecting fragments, sources and lexicon in a digital environment","SORBONNE UNIVERSITE","€2,497,750","All modern histories of Western linguistics start with its Greek origins (5th - 3rd cent. BC) and then, after mentioning the Latin Republican polymath Varro (1st cent. BC), jump several centuries to explore only some prominent, late figures (4th - 6th cent. AD). The aim of the LiTeRA project is to provide a holistic perspective on the birth and configuration of Roman linguistic science (2nd cent. BC - 3rd cent. AD), an essential moment in the evolution of Western culture. Although we have inheri",{"id":952,"funder":7,"programme":8,"title":953,"piName":14,"institution":954,"country":26,"year":13,"amount":955,"abstract":956},"cordis-european-research-council-award-101201278","Hunting sub-GeV Dark Sectors","ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA","€2,470,366","There is incontrovertible evidence that the Standard Model is not the ultimate theory of particles and interactions: it cannot explain neutrino masses, dark matter, our own existence (i.e. the Universe baryon asymmetry). A New Standard Theory must exist.The key question is: what is the new physics scale? In the past decades, a formidable effort took place to explore the TeV scale, culminating in the LHC experiments, but no evidence of new physics has been found.A change of paradigm may be requir",{"id":958,"funder":7,"programme":8,"title":959,"piName":14,"institution":901,"country":140,"year":13,"amount":960,"abstract":961},"cordis-european-research-council-award-101199768","A Metabolic Theory of Microbial Ecology","€2,757,847","Theoretical ecology has genuine potential to revolutionise microbiology, and vice versa. However, current models, such as the Lotka-Volterra equations, are typically too simplistic to apply and test rigorously. Critically, these models fail to capture microbial metabolism, which my lab and others have found central to predicting the ecology of diverse communities. My goal, therefore, is to develop a new theory of microbial ecology, rooted in metabolism, and to rigorously test it. We will capture",{"id":963,"funder":7,"programme":8,"title":964,"piName":14,"institution":901,"country":140,"year":13,"amount":91,"abstract":965},"cordis-european-research-council-award-101199352","The electrosolvation force: a new physical paradigm in chemistry and biology","Over the last several decades, dating back to the work of Langmuir, and Rosalind Franklin, the literature has consistently reported on a long-ranged attraction between particles in solution carrying electrical charge of the same sign. This attraction is not explained by standing theories and has remained an open conundrum. My laboratory has recently made important progress in elucidating the underpinnings of this phenomenon, introducing an “electrosolvation” force that drives spontaneous attract",{"id":967,"funder":7,"programme":8,"title":968,"piName":14,"institution":922,"country":12,"year":13,"amount":91,"abstract":969},"cordis-european-research-council-award-101140666","Harnessing RARA signalling for curative AML therapies","In acute promyelocytic leukaemia (APL), retinoic acid (RA) and arsenic trioxide (ATO) bind the PML\u002FRARA fusion to promote its degradation, derepressing unknown master regulatory genes and activating a PML\u002FP53 checkpoint which is required for APL cure. APL initiation deregulates Retinoic Acid Receptor a (RARA) signalling. These deregulations are likely shared with a sizable subset of non-APL acute myeloid leukaemia (AML): the 30% that overexpress normal RARA and exhibit some RA-sensitivity ex viv",{"id":971,"funder":7,"programme":8,"title":972,"piName":14,"institution":973,"country":110,"year":13,"amount":974,"abstract":975},"cordis-european-research-council-award-101198932","Macro Market Power and Distribution","UNIVERSIDAD POMPEU FABRA","€2,455,000","Market power is about the distribution of economic surplus between firms, customers and workers. In this proposal, I use modern heterogeneous agents macro tools that incorporate heterogeneity in firm productivity, in preferences, and in market structure. I investigate the macroeconomic mechanisms that link market power and distributional characteristics and formulate welfare-improving policies that lead to efficiency gains and re-distribution.I propose a unifying framework of market power and di",{"id":977,"funder":7,"programme":8,"title":978,"piName":14,"institution":973,"country":110,"year":13,"amount":979,"abstract":980},"cordis-european-research-council-award-101141287","Material Culture, Gender and Maintenance Activities in Making and Resisting Early Modern Colonial Globalization.  A Long-term Perspective from the Mariana Islands","€2,649,448","The proposed project will be the first to investigate the intimate connection between material culture, quotidian life, and gender in the making of and resistance to early modern colonial globalization. The 16th, 17th, and 18th centuries witnessed the rise of historical processes vital to moulding the world to its present shape. While scholars have extensively studied the worldwide translocations of people, goods and ideas, the fact that this globalization also took shape through the cross-conti",{"id":982,"funder":7,"programme":8,"title":983,"piName":14,"institution":984,"country":12,"year":13,"amount":14,"abstract":985},"cordis-european-research-council-award-101142682","Quantum Probes for High-Pressure Superconductivity","ECOLE NORMALE SUPERIEURE PARIS-SACLAY","Materials under high pressure exhibit exciting topics such as the superconductivity (SC) of hydrogen-rich molecular compounds (super-hydrides) in the long standing search of room-temperature SC. While pressures above 100 GPa can be routinely created in a diamond anvil cell (DAC), the tiny sample volume almost precludes the use of non-optical detection schemes to probe the sample properties. The project idea is to integrate nitrogen-vacancy (NV) centers in the DAC and use the optically detected m",{"id":987,"funder":7,"programme":8,"title":988,"piName":14,"institution":989,"country":12,"year":13,"amount":990,"abstract":991},"cordis-european-research-council-award-101201502","Single-spin magnetic resonance spectroscopy and imaging","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","€3,498,300","Magnetic resonance spectroscopy studies matter by probing the resonant frequencies and couplings of paramagnetic nuclei and unpaired electrons. It is a cornerstone of modern science, with numerous applications in condensed-matter physics, materials science, chemistry, biology, and medical imaging. A counterpart is low sensitivity. Conventional spectrometers need large numbers of identical objects to detect a signal. This is an issue for systems with inhomogeneous properties, since their ensemble",{"id":993,"funder":7,"programme":8,"title":994,"piName":14,"institution":995,"country":140,"year":13,"amount":996,"abstract":997},"cordis-european-research-council-award-101201485","Female Flourishing and the Economic Frontier","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","€2,482,322","Women’s economic flourishing is not only an equity concern: growing evidence shows significant efficiency gains from women entering male-dominated fields and collaborating with male colleagues. However, there is little work on the process through which these gains towards the efficient frontier can be realized, and how the benefits can be shared by all. This proposal, comprised of 7 projects, will shed light on how to spur inter-gender collaboration and trust, through 3 distinct channels: 1) Int",{"id":999,"funder":7,"programme":8,"title":1000,"piName":14,"institution":995,"country":140,"year":13,"amount":1001,"abstract":1002},"cordis-european-research-council-award-101200999","Incentives and Dynamics of Innovation","€1,587,328","Innovation is the key driver of competitiveness and growth. It supplants existing technologies and erodes the market position of firms. This creative destruction lies at the heart of endogenous growth models. This proposal studies how patent rights shape innovation incentives and the micro-dynamics of technological competition in Europe and the U.S.  Patent rights are a key policy instrument to enhance incentives, and it is critically important that patent-granting agencies function effectively.",{"id":1004,"funder":7,"programme":8,"title":1005,"piName":14,"institution":995,"country":140,"year":13,"amount":1006,"abstract":1007},"cordis-european-research-council-award-101200645","Pushing the Frontier of Heterogeneous Agent Macro: Expectations Formation and Economic Crises","€2,498,431","One of the key developments in macroeconomics research over the last three decades has been the incorporation of explicit heterogeneity into models of the macroeconomy. But one of the all-time biggest questions in macroeconomics has so far been out of reach for this approach: why do developed economies experience infrequent but large economic crises? This is due to a problematic feature of current heterogeneous agent (HA) models: the assumption of rational expectations means that agents forecast",{"id":1009,"funder":7,"programme":8,"title":1010,"piName":14,"institution":251,"country":12,"year":13,"amount":1011,"abstract":1012},"cordis-european-research-council-award-101142836","Evolutionary immunology: using insect models to unravel STING-dependent conserved and innovative antiviral strategies","€2,396,099","As we have seen with the emergence of viral pathogens like Ebola, ZIKA and SARS-CoV2, our societies are, and will continue to be, confronted to unknown and perilous viruses. To prepare for this, we propose to explore the diversity of antiviral genes in animals. Important signaling nodes have been conserved throughout evolution and regulate expression of antiviral genes that evolve dynamically in response to viral pressure. Because this occurs in parallel between different lineages, each animal h",{"id":1014,"funder":7,"programme":8,"title":1015,"piName":14,"institution":1016,"country":12,"year":13,"amount":91,"abstract":1017},"cordis-european-research-council-award-101201216","Capture-and-Release Organic Nanomaterials for Optical Sensing and Control of Cells","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","Fluorescence sensing materials enable detection of biologically active molecules at the cellular level, whereas photo-responsive materials for molecular uncaging allow controlling cellular processes. Would it be possible to merge these two research fields? The aim of CaptuRel is intelligent fluorescent nanomaterials undergoing bioinspired cycle of specific capture\u002Fsensing and photorelease of naturally present bioactive species, protons and neurotransmitters (NTs), for sensing and controlling che",{"id":1019,"funder":7,"programme":8,"title":1020,"piName":14,"institution":1016,"country":12,"year":13,"amount":1021,"abstract":1022},"cordis-european-research-council-award-101141553","Which Moral Influences on European penal and prison policies?","€2,416,984","The JUST_PEN Project aims to analyse the strategies private interest groups use to try to influence European penal and prison policies through notably litigation and judicial complaints lodged with the European Court of Human Courts and the Court of Justice of the European Union.  In relying notably on a current national research grant on the European Human Rights Justice under Moral Influences?, the JUST_PEN project will analyse whether or not the moral and religious values promoted by these pr",{"id":1024,"funder":7,"programme":8,"title":1025,"piName":14,"institution":1016,"country":12,"year":13,"amount":1026,"abstract":1027},"cordis-european-research-council-award-101140496","Fundamentals of Combustion Safety Scenarios for Hydrogen","€2,498,191","Hydrogen is a powerful energy vector but its deployment at the scale considered today by governments and companies cannot be achieved if safety associated to combustion hazards is not mastered and regulated. Hydrogen leaks occur and lead to fires and explosions which must be prevented. To do this, regulations are needed but these regulations are based today on an incomplete understanding of the fundamental mechanisms controlling the combustion of hydrogen in air or have to consider new usages of",{"id":1029,"funder":7,"programme":8,"title":1030,"piName":14,"institution":1016,"country":12,"year":13,"amount":1031,"abstract":1032},"cordis-european-research-council-award-101141259","The formation and evolution of the primordial planetary felsic crust","€2,883,478","A turning point for the whole planetary evolution, climate and habitability was the onset of felsic (i.e., enriched in Si and Al) crust formation 4.5  4.0 Gyr ago. To date, this onset can be traced using natural zircon mineral (ZrSiO4)-bearing rocks, as well as laboratory experiment and modelling. My project is based on cutting-edge experiments and modelling as well as field data acquisition on natural rock samples to construct a first comprehensive fundamental model of the primordial felsic cru",{"id":1034,"funder":7,"programme":8,"title":1035,"piName":14,"institution":1036,"country":189,"year":13,"amount":91,"abstract":1037},"cordis-european-research-council-award-101142786","Health, Cognition, Family, and Employment among Men","UNIVERSITETET I OSLO","Men are more likely than women to die prematurely, and a great deal of men’s excess mortality is preventable. Improving men’s health and cognition is not only critical for achieving gender equality, but also for enhancing and extending men’s potential to contribute to their families, the labour market and society as populations grow older. HOMME studies how men’s (changing) family and working lives influence their health and cognition. Men’s family and working lives are changing: Men now lag beh",{"id":1039,"funder":7,"programme":8,"title":1040,"piName":14,"institution":1041,"country":134,"year":13,"amount":1042,"abstract":1043},"cordis-european-research-council-award-101200311","MAterials Genome engineering for re-Inventing CONcrete","TECHNISCHE UNIVERSITEIT DELFT","€2,499,407","In MAGICON I propose a completely new philosophy for developing and designing concrete. I aim to conceptualize a strategy based on materials genome engineering that combines Experimental tools, Computational tools and Digital data. The MAGICON philosophy should make it possible to select and combine ingredients for concrete that result in optimized properties and behaviour. The need for reinventing concrete comes from  the urge to use greener and more environmental friendly binder systems and al",{"id":1045,"funder":7,"programme":8,"title":1046,"piName":14,"institution":1047,"country":79,"year":13,"amount":1048,"abstract":1049},"cordis-european-research-council-award-101200955","Engineered DNA Moiré Superlattices","UNIVERSITY OF STUTTGART","€2,498,737","Moiré patterns are commonly observed phenomena across all length scales. A moiré pattern arises from the spatial modulation of stacked sublattices, which have slightly different lattice constants and\u002For orientations. This pattern forms a superlattice with a larger periodicity, spanning multiple unit cells of the sublattices.       To date, moiré superlattices comprising sublattices with lattice constants of several nanometers have not been experimentally realized. Moiré superlattices at this len",{"id":1051,"funder":7,"programme":8,"title":1052,"piName":14,"institution":1016,"country":12,"year":13,"amount":1053,"abstract":1054},"cordis-european-research-council-award-101142565","Atomic-scale Photochemistry","€2,499,534","Photochemistry entails natural and artificial reactions that are activated optically, and is at the heart of fundamental processes such as photosynthesis, vision, polymerization, catalysis, or energy conversion Innovative approaches to gain control over photochemical reactions that relied on macro- and mesoscale manipulations of light (e.g., chemistry in an optical cavity, plasmon-enhanced reactions, etc.) were reported recently, but no strategy was proposed to address the photochemistry of a mo",{"id":1056,"funder":7,"programme":8,"title":1057,"piName":14,"institution":1058,"country":12,"year":13,"amount":1059,"abstract":1060},"cordis-european-research-council-award-101199917","Supramolecular Integration of Artificial Molecular Motors in Active Systems : Morphing, Adaptation, Propulsion","CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION","€2,499,986","Biomolecular motors are fundamental elements in the emergence of dynamic, self-sustaining, and evolving properties that characterize living systems. When fuelled by an external source of energy, they can perform and convert mechanical work into key functions such as catalysis, regulation, transport, actuation, and locomotion. This transduction of energy happens between hierarchical levels of self-organization, which maintain living systems out of thermodynamic equilibrium and link the unidirecti",{"id":1062,"funder":7,"programme":8,"title":1063,"piName":14,"institution":1041,"country":134,"year":13,"amount":1064,"abstract":1065},"cordis-european-research-council-award-101200868","From Buried Ocean to Surface Ice:  Spectral Signatures of Leaking Oceans on Icy Moons.","€2,461,240","In our solar system, most of the oceans are covered by kilometers of ices. These buried oceans, considered amongst the most promising places to host extraterrestrial life, are now a priority in both ESA and NASA’s programs for in situ observations with landing missions. To prepare for these programs, and the scientific return of current\u002Ffuture missions, we need to understand how buried oceans interact with the surface, the paths to reach them, and whether we can know more about their composition",{"id":1067,"funder":7,"programme":8,"title":1068,"piName":14,"institution":1016,"country":12,"year":13,"amount":1069,"abstract":1070},"cordis-european-research-council-award-101200828","Renormalization Group and Statistical Field Theory","€2,330,592","This proposed project aims to develop rigorous renormalization group arguments, based on ideas from analysis and probability, and to apply them to problems in statistical physics, probability, and fluid mechanics. The emphasis is on physical phenomena which exhibit behavior across a large range of length scales, often with erratic and irregular behavior on small scales and possibly diverging correlation lengths. The idea is to gradually coarse-grain the system using ideas from the quantitative t",{"id":1072,"funder":7,"programme":8,"title":1073,"piName":14,"institution":1016,"country":12,"year":13,"amount":1074,"abstract":1075},"cordis-european-research-council-award-101142048","Moving Bodies and Memories of African Slavery in South America","€2,499,958","The MOVING project is aimed at developing an ethnographic and multi-disciplinary methodology to study the bodily traces of Africa-originated slavery enduring in post-slavery and diasporic contexts. The project is rooted in an anthropology of the memories of slavery that the PI has been conducting mainly in Colombia for the past fifteen years, and in her previous work on bodies, senses, emotions and nationalism in India. As importantly, the PI is a certified practitioner of a conscious, embodied ",{"id":1077,"funder":7,"programme":8,"title":1078,"piName":14,"institution":1079,"country":12,"year":13,"amount":1080,"abstract":1081},"cordis-european-research-council-award-101199624","Lunar Impact’s Seismic and Telescopes European Network for Flash","INSTITUT DE PHYSIQUE DU GLOBE DE PARIS","€3,499,959","Terrestrial Planetary Seismology aims to revolutionize our understanding of planetary interiors and seismic activity. After the Mars interior exploration by InSight seismometer, the next steps will be on the Moon, with three seismometer deployments planned for 2026\u002F2027 : NASA's Far Side Seismic Suite (FSS) with a French spare InSight sensor, NASA's Artemis-3 Lunar Environment Monitoring Station, and the Chinese Chang'E-7 Lunar Seismometer.  This ERC project hinges on detecting and locating luna",{"id":1083,"funder":7,"programme":8,"title":1084,"piName":14,"institution":1041,"country":134,"year":13,"amount":1085,"abstract":1086},"cordis-european-research-council-award-101199794","Inertial Dense Suspensions (IDeS); Flows in between Laminar and Turbulent","€2,463,893","Inertial Dense Suspensions are very common in nature and industry, with examples including blood flow, recycling, waste slurry transport, additive manufacturing, and energy storage solutions. While they are of great practical importance, these suspension flows are poorly understood. A direct consequence is that we cannot predict even the most basic properties of these flows with sufficient accuracy. For instance, the current best models over- or underestimate the measured pressure drop in a susp",{"id":1088,"funder":7,"programme":8,"title":1089,"piName":14,"institution":995,"country":140,"year":13,"amount":14,"abstract":1090},"cordis-european-research-council-award-101200402","Uncovering Inequality in Health and Healthcare: Data-Driven Insights for Policy Change","HEALTHINEQ addresses the persistent and complex issue of health inequalities across socio-economic groups. Despite significant efforts in healthcare and public policy, these disparities remain a critical challenge. The proposal aims to explore and mitigate these inequalities by investigating the underlying mechanisms, from social determinants to disparities in healthcare access and technology.HEALTHINEQ aims to achieve this through three key objectives:1\u002F Measurement and Data Integration: HEALTH",{"id":1092,"funder":7,"programme":8,"title":1093,"piName":14,"institution":1016,"country":12,"year":13,"amount":1094,"abstract":1095},"cordis-european-research-council-award-101140677","Intensity Correlations for Stars","€3,499,421","The pioneering experiments of intensity correlations by Hanbury-Brown and Twiss more than 50 years ago not only allowed to measure the angular diameter of many bright stars, but it also motivated Roy Glauber to develop his quantum formalism of photon statistics. The advent of direct optical interferences of light collected by different telescopes developed in the beginning of the 70s, with superior performances in terms of signal to noise ratio and correspondingly reduced required observation ti",{"id":1097,"funder":7,"programme":8,"title":1098,"piName":14,"institution":1099,"country":110,"year":13,"amount":1100,"abstract":1101},"cordis-european-research-council-award-101201497","Multilingual Production Principles of Lexical Collocations","BARCELONA SUPERCOMPUTING CENTER CENTRO NACIONAL DE SUPERCOMPUTACION","€2,488,590","MaPPLexiC aims to fill the gap in modern language theories concerning the interpretation and description of one type of idiosyncratic word constructions that stands out in terms of its frequency of use and as a measure of language proficiency, namely lexical collocations, and refute the wide-spread assumption that their production is ad hoc and therefore cannot be described in systematic terms. Inspired by the dramatic advances in Deep Neural Networks (DNNs) MaPPLexiC considers a lexical colloca",{"id":1103,"funder":7,"programme":8,"title":1104,"piName":14,"institution":1105,"country":12,"year":13,"amount":1106,"abstract":1107},"cordis-european-research-council-award-101198463","Break-Through Innovation - R D Misallocation, Green Innovation, and the AI Revolution","COLLEGE DE FRANCE","€2,438,750","This research project will confront theory and data to analyze the underpinnings and the effects of breakthrough innovation. We explore three main questions.First question: How should we design R&D policy to induce breakthrough innovation? Why do we observe more incremental innovations in Europe than in the US? We shall address this question using an extension of the Schumpeterian growth paradigm where both the size and sources of markups differ across firms. Firms may be big as a result of brea",{"id":1109,"funder":7,"programme":8,"title":1110,"piName":14,"institution":1111,"country":40,"year":13,"amount":1112,"abstract":1113},"cordis-european-research-council-award-101141607","Understanding the molecular basis of protein folding disorders and protein quality control in muscle","FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH","€2,498,824","Mutations in certain proteins can cause their misfolding and aggregation, posing a potential threat to the health of an organism. Protein aggregation is counteracted by protein quality control (PQC) mechanisms that reduce the amounts of damaged molecules. As we age, however, the crucial surveillance mechanisms weaken and become less effective, leading to protein misfolding diseases. The most well-known protein disorders, or proteinopathies – Alzheimer's, Huntington's, and Parkinson's diseases – ",{"id":1115,"funder":7,"programme":8,"title":1116,"piName":14,"institution":567,"country":134,"year":13,"amount":91,"abstract":1117},"cordis-european-research-council-award-101200304","From harassing to harnessing beta-cells in type 1 diabetes","Type 1 diabetes (T1D) is generally believed to result from a mistake by the immune system leading to the autoimmune destruction of insulin-producing β-cells in the pancreatic islets of Langerhans. Based on my discoveries, I recently began to realise that the ‘mistake’ actually occurs in stressed β-cells, leading to the generation of neoantigens resulting from ribosomal infidelity (DRiP) that provoke the immune system to act. 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