[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-advanced-grant-2026":3,"awarded-stats-erc-advanced-grant":1129},{"awarded":4,"total":1128},[5,16,20,27,34,39,45,52,59,64,66,73,80,85,92,99,105,112,119,125,132,138,143,150,157,163,171,177,179,185,191,197,203,207,213,219,225,231,236,242,248,255,261,267,271,277,283,287,293,298,304,310,316,323,329,331,333,339,345,351,358,364,370,376,382,386,392,398,404,410,415,420,425,430,436,442,448,454,460,467,473,478,484,490,495,500,506,511,517,522,527,533,538,543,549,555,561,567,573,579,585,591,596,602,607,613,617,623,629,634,639,645,651,656,662,668,673,678,684,689,693,698,704,710,716,722,727,733,737,743,748,754,760,766,771,776,781,787,792,798,804,810,816,822,827,831,837,843,849,853,858,864,870,875,880,886,892,897,903,909,914,920,926,931,937,942,947,952,957,963,969,975,981,986,991,997,1002,1008,1012,1017,1022,1027,1033,1039,1045,1051,1056,1061,1066,1072,1077,1082,1088,1093,1099,1103,1108,1113,1118,1123],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-european-research-council-award-erc-adg-grappa-101053925","European Research Council","ERC Advanced Grant","Regions of symmetry in images of natural scenes and artworks","Lisa Koßmann","KU Leuven","BE",2026,null,"While established as an important contributor to shape or pattern “goodness,” mirror symmetry has yet to be extensively studied in complex images more closely resembling our everyday visual surroundings. With this work, we provide insights into symmetry detection and its underlying processes using a novel bounding-box method on 200 images of natural scenes and 200 images of artworks. In a large online study, 901 participants were asked to indicate regions of symmetry within each image by placing",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":14,"country":14,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2020-adg-neurometa-no-101020715-","Flexural modulus of sandwich structures through homogenisation: dynamic virtual fields versus quasi‑static RJS method","Túlio Hallak Panzera",{"id":21,"funder":7,"programme":8,"title":22,"piName":23,"institution":24,"country":25,"year":13,"amount":14,"abstract":26},"openalex-european-research-council-award-h2020-erc-adg-883370","A one-step volumetric biofabrication platform for complex hydrogel-based hollow biomaterials","João M. M. Rodrigues","University of Aveiro","PT","Rotational molding (RM) is a widely used industrial process for producing hollow polymeric structures, yet it remains largely unexplored for biomaterials fabrication. Here, a low-cost 3D-printed biofabrication platform is introduced that adapts the general concept of RM to generate tunable hollow constructs with high structural fidelity. Using uniaxial RM, tubular-like hydrogels with precisely controlled diameter and wall thickness are generated by crosslinking light-responsive natural-based pol",{"id":28,"funder":7,"programme":8,"title":29,"piName":30,"institution":31,"country":32,"year":13,"amount":14,"abstract":33},"openalex-european-research-council-award-erc-adg-295707-cooperation","Cooperation During the Gezi Park Protests","Benjamin Beranek","Missouri State University","US","In this paper, we compare behavior in the dictator, ultimatum, and public goods games before and during the Gezi Park protests in laboratory experiments conducted in Türkiye. In May 2013, protests began against the proposed destruction of Gezi Park—one of the few remaining green spaces in Istanbul’s city center—for the construction of a shopping mall. Quickly spreading across Türkiye, many ordinary citizens participated in the protests in the following weeks. The collective action demonstrated i",{"id":35,"funder":7,"programme":8,"title":36,"piName":37,"institution":38,"country":32,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2023-adg","H-NESSi: The hierarchical non-equilibrium systems simulation package","Thomas Blommel","University of California, Santa Barbara",{"id":40,"funder":7,"programme":8,"title":41,"piName":42,"institution":43,"country":44,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-adg-ga-101018520","Bacterial defense via RES-mediated NAD+ depletion is countered by phage phosphatases","Ilya Osterman","Weizmann Institute of Science","IL",{"id":46,"funder":7,"programme":8,"title":47,"piName":48,"institution":49,"country":50,"year":13,"amount":14,"abstract":51},"openalex-european-research-council-award-101141686-erc-2023-adg","A case-control study of the association between per- and polyfluoroalkyl substances (PFAS) and risk of postmenopausal breast cancer in the Danish diet cancer and health cohort","Tina Kold Jensen","University of Southern Denmark","DK","BACKGROUND: Exposure to per- and polyfluoroalkyl substances (PFAS) has been associated with breast cancer, however findings have been conflicting and few studies have examined cancer subtypes or risk among subgroups of women. METHODS: We used an individually matched case-control design, nested within the Danish Diet Cancer and Health cohort. We identified 500 incident breast cancer cases with available plasma samples among postmenopausal women aged 50 to 64 years in the Danish Cancer Registry an",{"id":53,"funder":7,"programme":8,"title":54,"piName":55,"institution":56,"country":57,"year":13,"amount":14,"abstract":58},"openalex-european-research-council-award-adg-101055270","Leukemic stem cell subtypes determine venetoclax resistance and therapeutic vulnerabilities in AML","Alexander Waclawiczek","German Cancer Research Center","DE","The BCL-2 inhibitor venetoclax has transformed the treatment of acute myeloid leukemia (AML), but relapse due to resistance of leukemic stem cells (LSCs) remains a major challenge. By molecular and functional profiling of LSCs from >150 patients, we identify four LSC subtypes. These mirror distinct hematopoietic lineage stages, which determine the expression ratio between the venetoclax target BCL-2 and resistance-inducing proteins MCL-1 and BCL-xL (MAC-score). Longitudinal analyses reveal that ",{"id":60,"funder":7,"programme":8,"title":61,"piName":62,"institution":11,"country":12,"year":13,"amount":14,"abstract":63},"openalex-european-research-council-award-adg-2023-u2013101133276","Diabetes Management Strategies in Intensive Care Settings","Greet Van den Berghe","Critically ill patients often develop hyperglycemia, which is associated with increased morbidity and mortality. Randomized controlled trials have shown that the benefits of tight glucose control (TGC) are context-dependent. TGC reduced morbidity and mortality in patients receiving early parenteral nutrition, using a protocol that included accurate glucose measurements and avoided insulin boluses. Benefit was less pronounced in patients not receiving early parenteral nutrition, which is associat",{"id":65,"funder":7,"programme":8,"title":61,"piName":62,"institution":11,"country":12,"year":13,"amount":14,"abstract":63},"openalex-european-research-council-award-adg-2017-u2013785809",{"id":67,"funder":7,"programme":8,"title":68,"piName":69,"institution":70,"country":71,"year":13,"amount":14,"abstract":72},"openalex-european-research-council-award-advanced-grant-batnmr-835073","Suppressing gliding in Ni-rich single-crystal cathodes by defect engineering","Clare P. Grey","University of Cambridge","GB","Defect engineering has been used for centuries to enhance the mechanical strength of metals and alloys, but its application to cathodes remains largely unexplored. Conventional cathode synthesis aims for defect-free crystals to maximize capacity, but such structures degrade easily through interlayer gliding and microcracking, both of which are reported for single-crystal LiNi 0.8 Mn 0.1 Co 0.1 O 2 (SC-NMC811). Dopant substitution or surface coating has been explored to address these issues but i",{"id":74,"funder":7,"programme":8,"title":75,"piName":76,"institution":77,"country":78,"year":13,"amount":14,"abstract":79},"openalex-european-research-council-award-adg-101139772","Lymphatic vessels invade bone in disease but are absent in health and regeneration","Bin Zhou","Center for Excellence in Molecular Cell Science","CN","A recent study reported the existence of lymphatic vessels in normal bone and suggested their involvement in bone regeneration after injury. However, this conclusion was based on approaches that do not allow unequivocal identification of the spatial localization of lymphatic endothelial cells (LECs). Here, we employed a Prox1-based genetic tool and a dual-recombinase-mediated LEC-specific labeling system to trace lymphatic vessels with high specificity. We found that LECs are present in the conn",{"id":81,"funder":7,"programme":8,"title":82,"piName":83,"institution":84,"country":71,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2019-adg-883107","Probabilistic spaces: Terrains of resilience targeting in an age of generative AI","Alexander Campolo","Durham University",{"id":86,"funder":7,"programme":8,"title":87,"piName":88,"institution":89,"country":90,"year":13,"amount":14,"abstract":91},"openalex-european-research-council-award-erc-adg-101200505","Jeans model for the shapes of self-interacting dark matter halos","Sean Tulin","York University","CA","The Jeans model is a semianalytical approach to modeling self-interacting dark matter (SIDM) that works remarkably well to reproduce the spherically averaged halo profiles from observations and simulations of relaxed galaxies and galaxy clusters. However, SIDM halos are not spherically symmetric in general since they respond to nonspherical baryon distributions and retain nonsphericity from their initial collapse. In this work, we generalize the Jeans model to describe SIDM density profiles and ",{"id":93,"funder":7,"programme":8,"title":94,"piName":95,"institution":96,"country":97,"year":13,"amount":14,"abstract":98},"openalex-european-research-council-award-advanced-grant-101052997-edison-","OvercomingBarriers in Solid Tumors: Lactate-FueledNanomotors Enhance Penetration and Reverse Immunosuppression","Ramón Martínez‐Máñez","Instituto de Salud Carlos III","ES","Abstract Solid tumors present a therapeutic challenge due to their dense extracellular matrix and metabolically immunosuppressive microenvironment, which limit drug penetration and immune clearance. To overcome these barriers, we describe an engineered lactate-powered Janus nanomotor (NM(dox)-LOx) composed of a platinum (Pt) nanodendrite and a mesoporous silica nanoparticle (MSN), loaded with doxorubicin (Dox) and functionalized with the enzyme lactate oxidase (LOx). In this design, LOx acts as ",{"id":100,"funder":7,"programme":8,"title":101,"piName":102,"institution":103,"country":71,"year":13,"amount":14,"abstract":104},"openalex-european-research-council-award-101142666-piano-erc-2023-adg","Trade agreements, trade facilitation and mutual recognition arrangements","Bernard Hoekman","Centre for Economic Policy Research","Governments use preferential trade agreements (PTAs), the WTO Trade Facilitation Agreement (TFA) and mutual recognition arrangements (MRAs) to reduce bilateral trade costs. Using data for 2010-2022 and a structural gravity framework, we assess the trade impact of a country-pair using all three policy instruments simultaneously. Our analysis considers MRAs for Authorized Economic Operator (AEO) programs that expedite customs clearance for certified actors in the supply chain. These are not produc",{"id":106,"funder":7,"programme":8,"title":107,"piName":108,"institution":109,"country":110,"year":13,"amount":14,"abstract":111},"openalex-european-research-council-award-adg-101200073","A reference protein atlas of the adult mouse brain vasculature","Liqun He","Uppsala University","SE","Current methods for assessing low-abundance proteins in individual cells are limited. As a result, cell functions are often inferred from single-cell RNA sequencing (scRNA-seq) data, which can be misleading due to the poor cross-gene correlation (different genes in the same cells) between messenger RNA (mRNA) and protein levels. To address this issue, we used isolated brain vascular fragments to study the blood–brain barrier. We applied a combination of deep bulk proteomic analysis, a proteomic ",{"id":113,"funder":7,"programme":8,"title":114,"piName":115,"institution":116,"country":117,"year":13,"amount":14,"abstract":118},"openalex-european-research-council-award-adg-786462-poc-101054365-and-poc-101189004-to-gb","Cblb Gene Editing in T Cells Sustains Expansion and Immunogenic CAR T Tumor Killing Under Chronic Antigenic Stimulation","Gottfried Baier","Innsbruck Medical University","AT","CBL-B is an intracellular E3 ubiquitin ligase that acts as a T cell checkpoint by raising activation thresholds and limiting effector function. Here, genetic targeting of CBL-B enhances the performance of adoptively transferred T cells and CAR T cells under tumor microenvironment-like stress. In fully immunocompetent mouse models, Cblb deficiency or transient Cblb silencing improves control of MC-38 colon carcinoma and autochthonous mammary tumors, demonstrating that CBL-B restrains anti-tumor i",{"id":120,"funder":7,"programme":8,"title":121,"piName":14,"institution":122,"country":110,"year":13,"amount":123,"abstract":124},"cordis-european-research-council-award-101265268","Currents of Life – Molecular Mechanism of Long-Range Biological Energy Transduction","STOCKHOLMS UNIVERSITET","€2,494,937","Life is powered by a membrane-bound protein machinery that captures chemical and light energy to sustain the cellular energy metabolism. At the molecular level, these processes are catalyzed by energy-transducing enzyme complexes that link proton-coupled electron transfer (PCET) reactions across remarkably large (>300 Å) molecular distances. The Complex I machinery is the largest (>1 MDa) and most intricate PCET enzyme known, initiating electron transport chains across all domains of life. It op",{"id":126,"funder":7,"programme":8,"title":127,"piName":128,"institution":129,"country":130,"year":13,"amount":14,"abstract":131},"openalex-european-research-council-award-erc-adg-787074-nucleoluschromatin","TCF3::HLF orchestrates an enhancer-promoter network with activation of MEF2C to promote immature HSC gene expression in leukemia","Raffaella Santoro","University of Zurich","CH","Abstract Oncogenic fusion transcription factors (TFs) frequently drive hematopoietic malignancies by altering gene expression in key developmental programs. TCF3::HLF is a fusion TF that characterizes a rare, treatment-resistant subtype of B-cell acute lymphoblastic leukemia (t(17;19) TCF3::HLF-positive B-ALL). Despite its clinical significance, the mechanisms by which TCF3::HLF induces leukemia are unclear. We used HiChIP mapping and genetic interference to analyze TCF3::HLF at the 3D-genome le",{"id":133,"funder":7,"programme":8,"title":134,"piName":135,"institution":136,"country":71,"year":13,"amount":14,"abstract":137},"openalex-european-research-council-award-erc-2013-adg-340755","Development and validation of a dementia risk prediction model for low- and middle-income countries: the 10\u002F66 study","Eduwin Pakpahan","Northumbria University","BACKGROUND: Most people with dementia live in LMICs, underscoring the need for LMIC-specific identification of high-risk individuals. This study aimed to develop and validate a simple dementia risk prediction model for these settings. METHODS: Data from seven 10\u002F66 Study sites were analyzed. Over 100 candidate predictors were screened based on existing models and the 2024 Lancet Commission, including LMIC-specific variables (eg, food insecurity and household assets). Predictors were selected usi",{"id":139,"funder":7,"programme":8,"title":140,"piName":141,"institution":56,"country":57,"year":13,"amount":14,"abstract":142},"openalex-european-research-council-award-erc-adg-angiomture-project-number-787181","LPL-Positive Endothelial Cells Control T-cell Homing in Liver Metastasis","Hellmut G. Augustin","Combination therapies involving vascular targeting drugs have shown promise in overcoming resistance to immunotherapy. However, the prerequisite for vascular modulation to evoke an effective antitumor T-cell response remains elusive. Tracing the transcriptional response of liver metastasis-associated peritumoral and tumor endothelial cells (TEC) to T-cell intervention, we discovered an immunomodulatory TEC subpopulation that highly expressed lipoprotein lipase (LPL). LPL+ TECs facilitated intrat",{"id":144,"funder":7,"programme":8,"title":145,"piName":146,"institution":147,"country":148,"year":13,"amount":14,"abstract":149},"openalex-european-research-council-award-advanced-grant-101053983-grinsun","LHCSR1 Functions as a Dimmer Switch for Light Harvesting","Roberto Bassi","University of Verona","IT","In oxygenic photosynthesis, high light leads to a set of photoprotective processes, known as nonphotochemical quenching, that are required for fitness. In moss and algae, the pigment-protein complex, light-harvesting stress-related (LHCSR), is crucial for photoprotection. Acidification of the thylakoid lumen under high light triggers the activation of LHCSR and the conversion of the xanthophyll violaxanthin into zeaxanthin, which is found within LHCSR. These interrelated molecular components com",{"id":151,"funder":7,"programme":8,"title":152,"piName":153,"institution":154,"country":155,"year":13,"amount":14,"abstract":156},"openalex-european-research-council-award-erc-advanced-grant-tarica-695674-","The Spatial Politics of Blockades: Disrupting Phosphate Industrial Production in Post‐2011 Tunisia","Diane Robert","Délégation Provence et Corse","FR","ABSTRACT This article examines blockades targeting the phosphate‐processing industry in the Gabes region of Tunisia following the uprisings of 2010–2011, questioning their contributions and limitations. Drawing on fieldwork conducted between 2017 and 2019, it foregrounds the spatial dimensions of blockades, conceived as ‘generative refusals’ that simultaneously intervene in industrial flows and produce socio‐political space. By focusing on territorially embedded and relational spatial practices,",{"id":158,"funder":7,"programme":8,"title":159,"piName":160,"institution":161,"country":71,"year":13,"amount":14,"abstract":162},"openalex-european-research-council-award-erc-2013-adg-339208","The psychosocial impact of receiving a polygenic risk score informing risk of prostate cancer","Elizabeth K. Bancroft","Royal Marsden NHS Foundation Trust","BACKGROUND: Use of polygenic risk scores (PRS) as a risk-stratification tool in cancer screening is an area of increasing interest. The BARCODE1 study is an observational prostate cancer screening study, investigating the use of PRS to risk-stratify people by risk of prostate cancer, with those identified as higher risk invited for prostate cancer screening. Participants of BARCODE1 were invited to take part in a psychosocial sub-study aiming to explore the effect of receiving a polygenic risk s",{"id":164,"funder":165,"programme":8,"title":166,"piName":167,"institution":168,"country":169,"year":13,"amount":14,"abstract":170},"openalex-horizon-europe-european-research-council-award-erc-adg-101200304","HORIZON EUROPE European Research Council","Limited efficacy of a therapeutic anti-CD40 monoclonal antibody to inhibit activated CD4 T cell autoimmunity in vitro","Bart O. Roep","Leiden University Medical Center","NL","Iscalimab is a nondepleting anti-CD40 monoclonal antibody, expected to suppress immune responses by blocking the costimulation by antigen-presenting cells through CD40-CD40L ligation. This therapeutic antibody indeed inhibited proliferation of B lymphocytes and TNF production by dendritic cells and is being tested in clinical trials to treat B cell mediated autoimmune diseases. Since iscalimab showed limited clinical benefit and did not improve kidney and liver transplantation outcomes compared ",{"id":172,"funder":7,"programme":8,"title":173,"piName":174,"institution":175,"country":169,"year":13,"amount":14,"abstract":176},"openalex-european-research-council-award-h2020-erc-2017-adg-788982-colmin","Chemical Maturation Controls Bioavailability of Fetuin‐A‐Mineral Complexes in Biomineralization","Nico Sommerdijk","Radboud University Nijmegen","ABSTRACT Living organisms must transport calcium and phosphate at high concentrations to enable bone formation without triggering uncontrolled mineral precipitation. Fetuin‐A binds calcium phosphate to form soluble calciprotein complexes, but how these complexes contribute to physiological mineralization has remained unclear. Here we show that Fetuin‐A‐based mineral complexes exist in functionally distinct states that determine mineral bioavailability. Using cryogenic and liquid‐phase electron m",{"id":178,"funder":7,"programme":8,"title":173,"piName":174,"institution":175,"country":169,"year":13,"amount":14,"abstract":176},"openalex-european-research-council-award-h2020-erc-2023-adg-101141998-revalve",{"id":180,"funder":7,"programme":8,"title":181,"piName":182,"institution":183,"country":117,"year":13,"amount":14,"abstract":184},"openalex-european-research-council-award-erc-2020-adg-101020093","Energy Shields for Fairness","Konstantin Kueffner","Institute of Science and Technology Austria","Runtime fairness is not a one-time constraint but a dynamic property evaluated over a sequence of decisions. To ensure fairness at runtime, it is necessary to account for past decisions, information neglected by conventional, static classifiers. Traditional fairness shields enforce runtime fairness abruptly, by intervening deterministically whenever a sequence of decisions violates the target for a running fairness measure. This motivates our main conceptual contribution: energy shields. An ener",{"id":186,"funder":7,"programme":8,"title":187,"piName":188,"institution":189,"country":155,"year":13,"amount":14,"abstract":190},"openalex-european-research-council-award-erc-adg-101097791-destop","Arf1 is involved in Neisseria meningitidis-induced cortical branched F-actin network reorganization","Guillaume Duménil","Inserm","Cells experience external forces that deform the plasma membrane to which they adapt by reorganizing their actin cytoskeleton. Here, using the extracellular bacterium Neisseria meningitidis as a model system, we explore how this bacterium reorganizes the cortical actin cytoskeleton subsequently to mechanical membrane deformations. Meningococci trigger the formation of tubular cellular plasma membrane protrusions by a previously described adhesion-driven process known as one-dimensional wetting. ",{"id":192,"funder":7,"programme":8,"title":193,"piName":194,"institution":195,"country":97,"year":13,"amount":14,"abstract":196},"openalex-european-research-council-award-erc-2024-adg-ga-101198761","OMA1 protects from liver injury and tumorigenesis during aging by controlling hepatic immunogenicity","José Antonio Enrı́quez","Spanish National Centre for Cardiovascular Research","Abstract Hepatic inflammation and immunosurveillance play major roles in the progression of liver cancer. A common trigger for hepatic inflammation is oxidative stress, which stems from mitochondrial dysfunction. Here, we demonstrate that deletion of the mitochondrial stress integrator OMA1 increases hepatic primary tumor incidence and impairs survival in mice. Persistent activation of the KEAP1-Nrf2 oxidative stress pathway in the absence of OMA1 promotes early liver injury, which progresses in",{"id":198,"funder":7,"programme":8,"title":199,"piName":200,"institution":201,"country":148,"year":13,"amount":14,"abstract":202},"openalex-european-research-council-award-adg-101019659","From Neanderthals to Homo sapiens: New palaeoecological and tephrocronological data from the MIS3 layers of Grotta-Riparo di Uluzzo C (Apulia, southern Italy)","Juan Ochando","University of Siena","The southern Italian Peninsula plays a crucial role as a biogeographical hotspot in Southern Europe, influenced significantly by the Mediterranean climate. This environment acted as a glacial refuge for diverse flora and fauna, humans included. This study employs pollen analysis on Mousterian and Uluzzian sediments from Grotta-Riparo di Uluzzo C in the Salento Peninsula (southern Italy) to reconstruct the vegetation landscapes encountered by the late Italian Neanderthals (thus far associated wit",{"id":204,"funder":7,"programme":8,"title":205,"piName":206,"institution":14,"country":14,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-adg-101018287","Orbital instability and spanwise vortex structure of unstable periodic orbits in large-eddy simulations of plane Couette flow","Genta Kawahara",{"id":208,"funder":7,"programme":8,"title":209,"piName":210,"institution":211,"country":148,"year":13,"amount":14,"abstract":212},"openalex-european-research-council-award-erc-adg-hyperspim-101139828","Optical spin glasses","Claudio Conti","Sapienza University of Rome","Spin-glass theory emerged in the 1980s as a merger between theoretical physics and condensed matter. Soon, physicists realized that spin glasses serve as a paradigm for complex systems, as underscored by the 2021 Nobel Prize in Physics, and for applications in machine learning and neuroscience, with a profound connection with the Hopfield model and Boltzmann machines, subjects of the 2024 Nobel Prize in Physics. However, the connection with optics and photonics is even more profound and fundamen",{"id":214,"funder":7,"programme":8,"title":215,"piName":216,"institution":217,"country":155,"year":13,"amount":14,"abstract":218},"openalex-european-research-council-award-erc-2020-adg-funlearn-101020573","SplineSplat: 3D Ray Tracing for Higher-Quality Tomography","Michaël Unser","Laboratoire d’Imagerie Biomédicale","We propose a method to efficiently compute tomographic projections of a 3D volume represented by a linear combination of shifted B-splines. To do so, we propose a ray-tracing algorithm that computes 3D line integrals with arbitrary projection geometries. One of the components of our algorithm is a neural network that computes the contribution of the basis functions efficiently. In our experiments, we consider well-posed cases where the data are sufficient for accurate reconstruction without the ",{"id":220,"funder":7,"programme":8,"title":221,"piName":222,"institution":223,"country":78,"year":13,"amount":14,"abstract":224},"openalex-european-research-council-award-erc-2019-adg","Genetic and linguistic landscapes of Gansu-Qinghai populations","Mengting Xu","Xiamen University","The Gansu-Qinghai (GQ) region is a critical Eurasian contact zone with exceptional linguistic and genetic diversity. However, genomic studies integrating genetic and linguistic evidence in areas with intensive language mixing remain limited. We conducted fine-scale genomic analyses on 153 new samples from four linguistically mixing or mixed regions: Linxia and Xiahe in Gansu, and Gan'gou and Wutun in Qinghai. Our findings reveal three primary ancestral components: Yellow River, western Eurasian ",{"id":226,"funder":7,"programme":8,"title":227,"piName":228,"institution":229,"country":230,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-101141445-u2014-elec-from-heat-u2014-erc-2023-adg","Pyroelectric power generator for autonomous systems","Emmanuel Defaÿ","University of Luxembourg","LU",{"id":232,"funder":7,"programme":8,"title":233,"piName":234,"institution":14,"country":14,"year":13,"amount":14,"abstract":235},"openalex-european-research-council-award-erc-adg-101020453-principles","DATA for: AI versus humans as authority figures: Evidence from a rule-compliance experiment","Sebastian Kube","DATA AND ANALYSIS FILES for: \"Can AI tell us what to do? Experimental evidence on rule compliance\", by Dominik Suri, Simon Gächter, and Sebastian Kube. ABSTRACT: Interactions between humans and artificial intelligence are becoming increasingly common across social and economic domains, yet the behavioral consequences of AI as an authority figure remain poorly understood. We investigate whether individuals differ in their willingness to comply with arbitrary rules depending on whether these rules",{"id":237,"funder":7,"programme":8,"title":238,"piName":239,"institution":240,"country":71,"year":13,"amount":14,"abstract":241},"openalex-european-research-council-award-adg-883786","Hydrogen Bonding within Dynamic \u003Csup>19\u003C\u002Fsup> F-Tagged Oligothiourea Foldamers in Solution and in Membranes","Lucia Trevisan","University of Bristol","High Resolution Image Download MS PowerPoint Slide Molecular conformation plays an integral role in biological signal transduction, with several classes of biomolecules using conformational changes to translate local inputs into spatially remote outputs. This natural communication mechanism has inspired the development of dynamic foldamers with the ability to use conformational changes as a communication mechanism. These foldamers include ethylene-bridged hydrogen-bonded oligo(thio)urea foldamer",{"id":243,"funder":7,"programme":8,"title":244,"piName":245,"institution":246,"country":155,"year":13,"amount":14,"abstract":247},"openalex-european-research-council-award-101162990-adg","The Pestov Identity on the Frame Bundle and Associated Homogeneous Fibrations","Andrei Moroianu","Centre National de la Recherche Scientifique","ABSTRACT We prove a global Pestov identity on the (orthonormal) frame bundle of a Riemannian manifold and deduce similar identities on associated homogeneous fibrations. As a particular example, this provides a concise proof of the Pestov identity on the unit tangent bundle of the manifold.",{"id":249,"funder":7,"programme":8,"title":250,"piName":251,"institution":252,"country":253,"year":13,"amount":14,"abstract":254},"openalex-european-research-council-award-advanced-grant-project-101200719-steadynmr-","Ultra‐Wideline 2D Correlations Among Low‐ \u003Ci>γ\u003C\u002Fi> Species in Solid‐State NMR via the Progressive Saturation of a Common Proton Reservoir","Rihards Aleksis","Latvijas Organiskās Sintēzes Institūts","LV","ABSTRACT Ultra‐wideline nuclear magnetic resonance (NMR) spectra arising from large chemical shift anisotropy and\u002For quadrupolar broadening can span several MHz, rendering two‐dimensional (2D) correlations between low‐γ nuclei subject to these interactions exceptionally challenging. The limited pulse excitation bandwidth, poor sensitivity, and weak internuclear couplings make correlations between such spins nearly impossible in practice. To deal with such cases, this study introduces the PROgres",{"id":256,"funder":7,"programme":8,"title":257,"piName":258,"institution":259,"country":57,"year":13,"amount":14,"abstract":260},"openalex-european-research-council-award-erc-adg-101200321-monofun-cv-","miRNA-26b Is Associated with Increased Connexin-40 Expression in Endothelial Cells Under Flow Conditions","Marcus Igl","Ludwig-Maximilians-Universität München","Endothelial cell dysfunction is the initial step in atherosclerosis, in which gap junction proteins such as connexin 40 (Cx40) might play an important role. Previously, we could demonstrate that miRNA-26b, a 21-nucleotide miRNA, is highly expressed in human atherosclerotic plaques and plays a key causal role in atherogenesis. There is evidence that miRNA-26b and Cx40 play crucial roles in sustaining endothelial health. However, their potential effects on atherosclerosis-related processes remain ",{"id":262,"funder":7,"programme":8,"title":263,"piName":264,"institution":265,"country":32,"year":13,"amount":14,"abstract":266},"openalex-european-research-council-award-erc-2019-adg-884902-softml","Dynamic bidirectional coupling of membrane morphology and rod organization in flexible vesicles","Stijn van der Ham","Inspire Institute","The ordering of rod-like particles in soft, deformable containers emerges from the interplay of anisotropic interactions, geometric confinement, and boundary compliance. This competition couples internal particle organization to container morphology, producing behavior distinct from both rigid confinement and bulk systems. Such coupling is also relevant to biological contexts in which filamentous structures are confined by deformable membranes. Using a minimal model combining experiments and sim",{"id":268,"funder":7,"programme":8,"title":269,"piName":270,"institution":116,"country":117,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-adg-786462","NR2F6-modified CAR T cells drive extrinsic immunogenic cell death and antigen-agnostic immunity in solid tumors","Victoria Klepsch",{"id":272,"funder":7,"programme":8,"title":273,"piName":274,"institution":275,"country":57,"year":13,"amount":14,"abstract":276},"openalex-european-research-council-award-erc-2020-adg","Achieving cell-type specific transduction with adeno-associated viral vectors in pigeons","Noemi Rook","Ruhr University Bochum","Birds are valuable models for studying learning, cognition, song, and vision, yet tools for controlling and recording brain activity with millisecond precision remain underutilized in avian research. Advances in methods such as chemogenetics, optogenetics, and in vivo imaging have transformed rodent studies but require gene delivery techniques, like adeno-associated viruses (AAVs), in non-transgenic species. This study validates AAV tools for precise gene expression in pigeons. We identified bot",{"id":278,"funder":7,"programme":8,"title":279,"piName":280,"institution":281,"country":71,"year":13,"amount":14,"abstract":282},"openalex-european-research-council-award-precision-smom-project-number-101198896-horizon-erc-erc-2024-adg","The characterisation and reactivity of a Rh \u003Csup> \u003Cscp>iii\u003C\u002Fscp> \u003C\u002Fsup> η \u003Csup>1\u003C\u002Fsup> -σ-alkane complex and the role of a structurally responsive phosphine ligand in solid-state molecular organometallic chemistry","Joe C. Goodall","University of York","to a weakly coordinating σ-alkane. These reversible bond activations of the chelating ligand in response to changes in the co-ligands demonstrate that significant structural reorganisation is possible in the crystalline environment.",{"id":284,"funder":7,"programme":8,"title":285,"piName":286,"institution":14,"country":14,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2024-adg","Inventory of User Expectations for Technology (iExpect)","Steeven Villa",{"id":288,"funder":7,"programme":8,"title":289,"piName":290,"institution":291,"country":117,"year":13,"amount":14,"abstract":292},"openalex-european-research-council-award-erc-2023-adg-project-eft-xyz","Chiral symmetry restoration effects onto the meson spectrum from a Dyson-Schwinger and Bethe-Salpeter approach","Anonymous","University of Graz","Light meson spectra are studied in a Dyson-Schwinger\u002FBethe-Salpeter approach to quantum chromodynamics (QCD). By varying the interaction strength of three sets of models for the quark-antiquark interaction, the transition from the chiral symmetric to the chirally broken regime in the vacuum is studied. The simplest type of these models leads to degenerate meson spectra for a large domain of the strength parameter. The more sophisticated and thus more realistic models show significantly smaller p",{"id":294,"funder":7,"programme":8,"title":295,"piName":296,"institution":24,"country":25,"year":13,"amount":14,"abstract":297},"openalex-european-research-council-award-erc-2019-adg-883370","Shaping Function: Polymeric 3D Systems With Unconventional Geometries for Biomedical Applications","M Oliveira","Polymer geometry is a primary determinant of physical behavior and biological performance. Beyond conventional spherical and bulk morphologies, unconventional three-dimensional (3D) architectures - ranging from anisotropic particles and fibers to complex membrane-based systems - have emerged as powerful tools for biomedicine. Advances in fabrication methods, including microfluidics, lithography, and physical deformation techniques, now enable precise control of particle shape, anisotropy, and co",{"id":299,"funder":7,"programme":8,"title":300,"piName":301,"institution":302,"country":148,"year":13,"amount":14,"abstract":303},"openalex-european-research-council-award-erc-advanced-grant-835227-3","Double-coated PLGA nanoparticles with hierarchical surface architecture for CD44-targeted siRNA delivery","Fabiana Quaglia","Federico II University Hospital","Efficient delivery of small interfering RNA (siRNA) remains a materials challenge because it requires nanocarriers that stabilize polyanionic cargo, support cellular interactions, and enable cytosolic delivery. Although poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) are used due to biocompatibility, biodegradability, and regulatory acceptance, siRNA delivery with PLGA requires interfacial engineering to meet these constraints. Here, a modular double-coated PLGA NP platform (dcNPs2.0) i",{"id":305,"funder":7,"programme":8,"title":306,"piName":307,"institution":308,"country":32,"year":13,"amount":14,"abstract":309},"openalex-european-research-council-award-erc-2016-adg-741966","Senescence dynamics define therapeutic windows for Duchenne muscular dystrophy in DBA\u002F2-mdx mice","Aina Calls-Cobos","Fleet Science Center","BACKGROUND: Duchenne muscular dystrophy (DMD) is a severe X-linked disorder marked by progressive muscle degeneration and regeneration, inflammation and fibrosis. Cellular senescence has emerged as a potential driver of chronic muscle damage, yet its temporal dynamics and therapeutic relevance remain unclear. METHODS: We analyzed senescent cell burden in skeletal and cardiac muscles of the DBA\u002F2-mdx mouse model, which closely mimics features of human DMD. The senolytic combination of dasatinib a",{"id":311,"funder":7,"programme":8,"title":312,"piName":313,"institution":314,"country":117,"year":13,"amount":14,"abstract":315},"openalex-european-research-council-award-adg-101142075","Retrovirus insertions in host transcripts trigger de novo piRNA immunity","Baptiste Rafanel","Institute of Molecular Biotechnology","How host organisms adapt their defense systems to newly invading transposable elements remains poorly understood. Here, we show how Drosophila melanogaster acquired PIWI-interacting RNA (piRNA)-mediated immunity against the endogenous retrovirus Tirant. We uncover two distinct modes of de novo piRNA biogenesis by combining genetics, small RNA profiling, and population genomics. The primary route involves antisense insertions into the flamenco cluster, a master locus for transposon control. Unexp",{"id":317,"funder":7,"programme":8,"title":318,"piName":319,"institution":320,"country":321,"year":13,"amount":14,"abstract":322},"openalex-european-research-council-award-101200758-phylfun-erc-2024-adg-","Global dataset of soil eukaryotic communities created with a uniform protocol and long read sequencing","Vladimir Mikryukov","University of Tartu","EE","N, as well as P, K, Ca, Mg, and total C and N contents. GloSED is the first database that enables ecological and biogeographic studies of entire soil eukaryotic communities from local to global scales.",{"id":324,"funder":7,"programme":8,"title":325,"piName":326,"institution":327,"country":57,"year":13,"amount":14,"abstract":328},"openalex-european-research-council-award-erc-advanced-grant-no-101021358","Enantioselective Cupraelectrocatalyzed C−H Activation for C−Het Bond Formation","Prof. Dr. Lutz Ackermann","University of Göttingen","Chiral aryl phosphorus compounds are key motifs in medicinal chemistry, materials science, and agrochemistry. Electrochemical, transition-metal-catalyzed C−H activation offers an economical route to these structures. However, enantioselective C−H phosphorylation of ferrocenyl derivatives catalyzed by earth-abundant metals has remained elusive. Here we disclose the enantioselective cupraelectrocatalyzed C−H phosphorylation of ferrocenyl amides, providing planar chiral ferrocenylphosphorus compoun",{"id":330,"funder":7,"programme":8,"title":61,"piName":62,"institution":11,"country":12,"year":13,"amount":14,"abstract":63},"openalex-european-research-council-award-adg-2023-101133276",{"id":332,"funder":7,"programme":8,"title":61,"piName":62,"institution":11,"country":12,"year":13,"amount":14,"abstract":63},"openalex-european-research-council-award-adg-2017-785809",{"id":334,"funder":7,"programme":8,"title":335,"piName":336,"institution":337,"country":110,"year":13,"amount":14,"abstract":338},"openalex-european-research-council-award-adg-101097824","The temperature dependence of amyloid \u003Ci>β\u003C\u002Fi> solubility reveals the hydrophobic effect as the main driving force for fibril formation","Max Lindberg","Lund University","The aggregation of amyloid proteins into fibrillar and oligomeric aggregates is linked to a number of neurodegenerative diseases. While the disease onset remains elusive in many cases, an understanding of the driving forces for the aggregation may help finding possible causes. While effects on amyloid formation kinetics are more commonly studied, gaining insights into these driving forces require a thermodynamic approach with equilibrium measurements. Here we investigate the temperature dependen",{"id":340,"funder":7,"programme":8,"title":341,"piName":14,"institution":342,"country":110,"year":13,"amount":343,"abstract":344},"cordis-european-research-council-award-101198870","Integrable gauge theories at finite temperature","UPPSALA UNIVERSITET","€2,456,500","We propose a project to  explore the properties of supersymmetric gauge theories at finite temperature, with special emphasis on those that are integrable in the large N limit. In particular we study the de-confinement of these theories using the newest integrability methods which have recently proved to be a powerful tool in finding the Hagedorn temperature  as a function of the theory's coupling.  Progress in this field can lead to better understanding of the long unsolved problem of confineme",{"id":346,"funder":7,"programme":8,"title":347,"piName":14,"institution":348,"country":57,"year":13,"amount":349,"abstract":350},"cordis-european-research-council-award-101201020","Brain-inspired Computational Memory","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","€2,493,073","Deep neural networks (DNNs) have transformed the field of AI in recent years. However, a significant challenge persists in the form of inefficient hardware implementations of DNNs. Computation in memory (CIM) is an emerging approach that tackles the processor-memory divide in modern computing systems, enhancing their suitability for DNNs. CIM draws inspiration from certain computational principles found in the human brain, such as hard-wired neural networks and analogue processing.A key question",{"id":352,"funder":7,"programme":8,"title":353,"piName":14,"institution":354,"country":355,"year":13,"amount":356,"abstract":357},"cordis-european-research-council-award-101198795","Numerical Analysis for Stable AI","THE UNIVERSITY OF EDINBURGH","UK","€2,498,941","From a numerical analysis perspective I will identify, quantify and mitigate vulnerabilities in current artificial intelligence (AI) algorithms.Novel mathematical research will emerge along six overlapping axes:Inevitability: rigorously understand the inescapable endgame of the attack-versus-defence paradigm. Under what conditions is it inevitable that adversaries willsucceed? Formalizing such conditions will allow us to understand and, where possible, overcome current AI instabilities.Editabili",{"id":359,"funder":7,"programme":8,"title":360,"piName":14,"institution":361,"country":57,"year":13,"amount":362,"abstract":363},"cordis-european-research-council-award-101199253","Efficient odour representations in the olfactory bulb: Flexible lateral interactions synchronize co-active columns","UNIVERSITAET REGENSBURG","€3,453,563","How is the percept of a smell generated from the fractionated representation of odours at the periphery where olfactory receptor channels detect structural elements of odour molecules? While this problem seems akin to the detection of a “Gestalt”\u002Fobject by the visual system using its contours, there is a fundamental difference between olfaction and vision due to the discontinuous, non-topographical nature of odour representation. Recently my group has discovered intriguing subcellular mechanisms",{"id":365,"funder":7,"programme":8,"title":366,"piName":14,"institution":367,"country":355,"year":13,"amount":368,"abstract":369},"cordis-european-research-council-award-101198347","CONTRACT: Conformal Calibration for Reliable AI-Based Wireless Communications","Northeastern University - London","€2,489,890","CONTRACT sets out to investigate a novel, theoretically principled, framework for the reliable  deployment of artificial intelligence (AI)-based black-box models in wireless systems. Given the highly non-deterministic patterns of traffic and connectivity conditions, AI is currently viewed as an essential technology to ensure the support of communication services with widely heterogeneous performance requirements, ranging from cloud gaming to Industry 4.0. However, AI ``apps'' are, by and large, ",{"id":371,"funder":7,"programme":8,"title":372,"piName":14,"institution":373,"country":57,"year":13,"amount":374,"abstract":375},"cordis-european-research-council-award-101199828","Assured Recompilation of Vintage Executables via Binary Lifting: Unfreezing Legacy Software from Obsolete Toolchain Dependence","TECHNISCHE UNIVERSITAT BERLIN","€2,500,000","A lot of everyday infrastructure is powered by legacy software that depends on obsolete toolchains. Such software is literally “stuck in time” and cannot benefit from innovations in modern compilers such as automated security mitigations applied during compilation. There are often other undesirable consequences, such as a need to use outdated hardware platforms.Unfortunately, modernizing such legacy software isn’t as simple as taking the ancient source code (if it exists) and re-running it throu",{"id":377,"funder":7,"programme":8,"title":378,"piName":14,"institution":379,"country":355,"year":13,"amount":380,"abstract":381},"cordis-european-research-council-award-101201212","State-tech relations in the datafied welfare state: Examining the computational transformation of the European social model","GOLDSMITHS' COLLEGE","€2,498,705","Use of data-driven technologies by public bodies is now well-established across central pillars of European welfare states, from predictive benefit fraud in social security to safeguarding apps in schools to algorithmic diagnostics in health. Yet we still lack a proper understanding of what the datafied welfare state entails, and, crucially, what its relationship with the providers of such technologies is, and with what implications. This project investigates the relationship between the welfare",{"id":383,"funder":7,"programme":8,"title":384,"piName":14,"institution":373,"country":57,"year":13,"amount":374,"abstract":385},"cordis-european-research-council-award-101201067","Resolve human autoantigen-specific regulatory T cell responses","Antigen-specificity is the key feature of adaptive immunity, orchestrated by CD4 T helper (Th) cells. A small CD4+ subset of autoreactive Foxp3+ regulatory T cells (Tregs) secures tolerance against self and contributes to tissue homeostasis and regeneration. It is a central question in immunology how Tregs exert these various functions. In humans, however, self-specific Treg and Th cells are challenging to track and thus remain poorly characterized. In particular, the specific autoantigens targe",{"id":387,"funder":7,"programme":8,"title":388,"piName":14,"institution":389,"country":148,"year":13,"amount":390,"abstract":391},"cordis-european-research-council-award-101200514","Optimal Transport and Metric Structures for Evolution Problems","UNIVERSITA COMMERCIALE LUIGI BOCCONI","€2,186,890","Several evolution problems, such as gradient flows or rate-independent processes, are governed by variational principles which are extremely useful for studying the existence, stability, and structural properties of solutions by simple and general constructive approximation methods.Deep and beautiful ideas from the theory of Optimal Transport have contributed new insights and additional challenging questions to this scenario and have motivated flourishing and original developments. On the one ha",{"id":393,"funder":7,"programme":8,"title":394,"piName":14,"institution":395,"country":396,"year":13,"amount":374,"abstract":397},"cordis-european-research-council-award-101199930","New Horizons of Parameterized Complexity","UNIVERSITETET I BERGEN","NO","Parameterized Complexity (PC) provides an approach to moving beyond classic worst-case analysis of algorithms by focusing on multivariate algorithms whose performance is influenced by several parameters beyond input size. While it has been successful in various algorithmic domains, particularly those involving discrete objects like graphs, sets, matroids, or Boolean formulas, PC remains underutilized in areas involving geometric and algebraic objects such as points, vectors, linear spaces, or ma",{"id":399,"funder":7,"programme":8,"title":400,"piName":14,"institution":401,"country":12,"year":13,"amount":402,"abstract":403},"cordis-european-research-council-award-101199019","Mapping the Controllosphere","UNIVERSITEIT GENT","€2,480,212","The sensation of cognitive effort is integral to everyday human experience, is a core construct in psychological theories of behavior, and contributes to multiple psychiatric disorders like ADHD and depression. However, despite decades of study the neural origin and functional purpose of cognitive effort remain poorly understood. This constitutes one of the most important outstanding questions in cognitive neuroscience and a major challenge to mental health research. Recently, I proposed a new, ",{"id":405,"funder":7,"programme":8,"title":406,"piName":14,"institution":407,"country":97,"year":13,"amount":408,"abstract":409},"cordis-european-research-council-award-101198268","Synthesising a macroscopic quantum superposition of a nanotube","FUNDACIO INSTITUT DE CIENCIES FOTONIQUES","€2,871,796","One major quest in physics is to extend quantum superposition states from the microscopic to the macroscopic world. To achieve this, we need to explore innovative approaches for synthesizing macroscopic quantum superpositions of massive objects. While recent advancements have demonstrated quantum non-Gaussian states of motion in mechanical oscillators, the delocalization achieved has been only marginally larger than the zero-point motion. QTube aims to address this limitation by quantum delocali",{"id":411,"funder":7,"programme":8,"title":412,"piName":14,"institution":413,"country":12,"year":13,"amount":374,"abstract":414},"cordis-european-research-council-award-101200558","Posthuman Music: Creative Practices after AI and Blockchain.","ORPHEUS INSTITUUT VZW","Artificial Intelligence (AI) and blockchain technologies are becoming increasingly intertwined with human creativity, leading to novel forms of ‘posthuman’ musical expression that decentralize traditional notions of creative agency, authorship, ownership, and the ontology of the artwork. This poses unprecedented challenges and opportunities for new creative practices that need to be investigated, both scholarly and artistically. This project explores the transformative impact of AI and blockchai",{"id":416,"funder":7,"programme":8,"title":417,"piName":14,"institution":418,"country":12,"year":13,"amount":374,"abstract":419},"cordis-european-research-council-award-101200014","Media Production of Prison Communities","UNIVERSITEIT ANTWERPEN","Incarceration is widely depicted in films, TV, and the news, but prison communities—imprisoned people, their families, and anti-prison activists—are seldom recognized as media producers. Developing a transnational, collaborative, and comparative model of media justice, this project examines textual, visual, and sound media created by prison communities. It focuses on France, Turkey, the UK, and the US, where racial and ethnic discrimination stimulated mass incarceration of minorities from the mi",{"id":421,"funder":7,"programme":8,"title":422,"piName":14,"institution":389,"country":148,"year":13,"amount":423,"abstract":424},"cordis-european-research-council-award-101200947","The OrigINs of FINancial FragilITY","€2,057,919","Banking crises are recurrent phenomena. They lead to large declines in economic activity and share two features: i) they are oftentriggered by runs, i.e., sudden withdrawals by depositors; and ii) they follow episodes of deregulation and\u002For lax supervision.The 2023 banking turmoil in the U.S. is no exception. After the relaxation of prudential rules in 2018, three midsized banks faceddistress as a result of runs, leading to three of the largest failures in history. Motivated by these events, the",{"id":426,"funder":7,"programme":8,"title":427,"piName":14,"institution":418,"country":12,"year":13,"amount":428,"abstract":429},"cordis-european-research-council-award-101200904","Modernist Authors' Reading: Genesis in Authors' Libraries","€2,448,053","MARGINAL examines authors’ creativity through the traces of their own reading. The project starts from the idea that knowing what and how a writer read can help us understand the origins of their work. A work of literature often starts in the margins of another book.The project focuses on the reading habits of three modernist authors – Virginia Woolf, James Joyce and Samuel Beckett. The rationale behind the selection of these case studies is based on a twentieth-century crisis of ‘encyclopedism’",{"id":431,"funder":7,"programme":8,"title":432,"piName":14,"institution":433,"country":117,"year":13,"amount":434,"abstract":435},"cordis-european-research-council-award-101199663","Representation theory, equivariant topology and Langlands duality via fixed point schemes","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","€2,499,576","We propose a three-way dictionary between representation theory of complex semisimple Lie groups,equivariant topology of affine Schubert varieties and mirror symmetry for Langlands dual Hitchin systemsvia the language of fixed point schemes. This unified framework will yield new insights and advanceswithin these fields, with applications extending to other areas of mathematics and quantum physics.We introduce big algebras, which are commutative algebras attached to representations of complex sem",{"id":437,"funder":7,"programme":8,"title":438,"piName":14,"institution":439,"country":97,"year":13,"amount":440,"abstract":441},"cordis-european-research-council-award-101199747","Astrocytic metabolism-driven epigenetics at the cornerstone of cognitive aging","UNIVERSIDAD DE SALAMANCA","€2,467,500","Cognitive impairment is a major source of disability and dependence during aging. Up to 40% of dementia cases are attributable to modifiable environmental risk factors, namely lifestyle, which can be actionable for prevention before the onset of cognitive decline. Physical activity and nutrition comprise promising modifiable factors affecting cognitive aging, but how the lifestyle affects cognition is not fully explained. Because of their unique location at the interface between blood vessels an",{"id":443,"funder":7,"programme":8,"title":444,"piName":14,"institution":445,"country":97,"year":13,"amount":446,"abstract":447},"cordis-european-research-council-award-101200674","Sub-Neptunes as Predecessors for Earth-like planets Atmospheres Research for Habitability with the ELTs","INSTITUTO DE ASTROFISICA DE CANARIAS","€2,453,750","One of the most significant discoveries of the past decades is the realization that there are more planets than stars in our Galaxy, with a planet diversity that has far surpassed our expectations. A major focus of 21st-century astronomy is the characterization of Earth-sized planets in the habitable zones (HZPs) around nearby M dwarfs and the search for possible biomarkers in their atmospheres. This is driving the development of advanced, dedicated space missions and ground-based Extremely Larg",{"id":449,"funder":7,"programme":8,"title":450,"piName":14,"institution":451,"country":355,"year":13,"amount":452,"abstract":453},"cordis-european-research-council-award-101199672","Transforming the Story of the Arabic Book, 700–1800:  Knowledge, Information Technology, and the Arabic Book","THE AGA KHAN UNIVERSITY (INTERNATIONAL) IN THE UNITED KINGDOM","€2,547,189","The premodern Arabic textual tradition between 700 and 1800 is one of the most prolific in human history, with the number of surviving works surpassing the extant production of any other pre-print culture except perhaps imperial China or Sanskritic India. These texts can now be studied in completely new ways using pioneering digital technology that can identify textual units displaying what one scholar has termed ‘extended textual similarity’. This means not only word-for-word matching, which ca",{"id":455,"funder":7,"programme":8,"title":456,"piName":14,"institution":457,"country":148,"year":13,"amount":458,"abstract":459},"cordis-european-research-council-award-101201479","Between Fixism and Evolutionism: The Origin of Species in Medieval Thought","UNIVERSITA DEGLI STUDI DI MILANO","€2,424,186","It is commonly believed that the debate on the nature of living species and their possible evolution has no real history prior to the 18th century. The roots of this assumption lie in the belief that the entire previous tradition had been dominated by the combination of the Aristotelian doctrine of the eternity of species (fixism) and Jewish, Christian and Islamic creationism. The core hypothesis of SPECIES is that, on the contrary, the Middle Ages produced a significant and sophisticated series",{"id":461,"funder":7,"programme":8,"title":462,"piName":14,"institution":463,"country":464,"year":13,"amount":465,"abstract":466},"cordis-european-research-council-award-101200199","Agents of Cohesion in the Governance of an Empire: the Anthropogeography of Byzantium, 7th to 12th centuries","ACADEMY OF ATHENS","EL","€2,492,721","Crucial to Byzantium’s survival against several post 6th-century external foes was the introduction of the theme-system (military-territorial units), which sealed its provincial administration for five centuries. The long debate on this institution, often biased by anachronistic evidence from literary sources, has gained new impetus through the study of seals, the tiny lead disks that the Byzantines used to secure and authenticate their correspondence. The plethora of irrefutable evidence that s",{"id":468,"funder":7,"programme":8,"title":469,"piName":14,"institution":470,"country":57,"year":13,"amount":471,"abstract":472},"cordis-european-research-council-award-101201472","Bridging scales for integrated high-resolution modeling of the long-term transition to sector-coupled net-zero energy systems","POTSDAM-INSTITUT FUR KLIMAFOLGENFORSCHUNG EV","€2,493,601","The rapid growth of solar and wind power, as well as demand electrification technologies, increasingly underscores that successful climate change mitigation strategies will heavily rely on sector-coupled energy systems, in which renewables-dominated electricity is used for previously non-electric end-uses and fuels. Under such sector-coupling, the integration of variable renewable energy  (VRE) and demand-side electrification are highly synergistic; cheap VRE makes electrification attractive, wh",{"id":474,"funder":7,"programme":8,"title":475,"piName":14,"institution":418,"country":12,"year":13,"amount":476,"abstract":477},"cordis-european-research-council-award-101200889","Direct on Sputum Sequencing to Interrupt Transmission of Rifampicin Resistant Tuberculosis","€2,499,855","The DiSrupT RR-TB pragmatic cluster randomized trial (CRT) will tackle the ongoing public health threat of rifampicin-resistant tuberculosis (RR-TB) and prevent the emergence of bedaquiline-resistant tuberculosis (BDQR-TB) as a new public health crisis.  The trial aims to evaluate an innovative all-in-1 solution for whole genome sequencing (WGS): the recently launched QIAseq xHYB Mtb assay for WGS directly on sputum (dWGS) in combination with Illumina sequencing and the novel digital MAGMA-MICK ",{"id":479,"funder":7,"programme":8,"title":480,"piName":14,"institution":481,"country":355,"year":13,"amount":482,"abstract":483},"cordis-european-research-council-award-101200322","Biosocial Security: Social Science Transformations of Biosecurity","THE UNIVERSITY OF EXETER","€2,499,723","Biosecurity, the management of biological threats to humans, animals, and environments, is critical for health, economy, pandemic preparedness, and food security. In agricultural settings, it involves protecting livestock and workers from infectious diseases. The tendency is to take an engineering approach, aiming to minimise system breaches or failures. But this Biosecurity I approach is failing. Infection pressures are growing with climate and other environmental changes. Resulting livestock s",{"id":485,"funder":7,"programme":8,"title":486,"piName":14,"institution":487,"country":355,"year":13,"amount":488,"abstract":489},"cordis-european-research-council-award-101198691","Global Methane Politics","UNIVERSITY OF LEEDS","€2,499,924","The ambition of the Global Methane Politics project is to produce a pioneering body of research that simultaneously establishes the distinctiveness of methane politics, investigates and demonstrates the most significant political obstacles to methane emissions reduction, and has transformative impacts on global methane and climate policies and practices. Research on methane politics is urgently needed because 1) methane is the second largest contributor to anthropogenic climate change; 2) reduci",{"id":491,"funder":7,"programme":8,"title":492,"piName":14,"institution":493,"country":117,"year":13,"amount":374,"abstract":494},"cordis-european-research-council-award-101199346","Archaeal keystone species in host microbiomes: Understanding and controlling Methanobrevibacter for Environmental and Health Benefits","MEDIZINISCHE UNIVERSITAT GRAZ","Archaea, the most ancient domain of life, play a crucial yet largely underappreciated role in human microbiomes and Earth's nutrient cycles. Among them, Methanobrevibacter species are particularly important for methane production in ruminants, accounting for up to 6% of anthropogenic greenhouse gas emissions and are prevalent in animal and plant microbiomes. In recent years, I have become intrigued by the impact of Methanobrevibacter on human physiology. Our research has shown that two distinct ",{"id":496,"funder":7,"programme":8,"title":497,"piName":14,"institution":348,"country":57,"year":13,"amount":498,"abstract":499},"cordis-european-research-council-award-101197608","Intermediate-mass black holes in the era of gravitational-wave astronomy","€2,497,403","Intermediate-mass black holes (IMBHs), with masses ranging from 10^2 to 10^5 solar masses, are crucial for understanding the growth of supermassive black holes across cosmic ages, but their formation mechanisms remain an open question, despite being in the spotlight for several years. The recent detection of gravitational-wave (GW) events in the IMBH regime demonstrates the potential of GW astronomy to discover IMBHs, and underscores the need for new models to interpret this emerging population.",{"id":501,"funder":7,"programme":8,"title":502,"piName":14,"institution":503,"country":110,"year":13,"amount":504,"abstract":505},"cordis-european-research-council-award-101201024","Precise optical synchronization of high-speed electronics with microcombs","CHALMERS TEKNISKA HOGSKOLA AB","€3,499,696","Laser frequency combs based on mode-locked lasers are extraordinary photonic devices that have revolutionized precision frequency synthesis and metrology in the 21st century. They have enabled groundbreaking developments such as optical clocks, femtosecond-level timing synchronization, and ultra-pure microwave generation.Microresonator-based frequency combs (microcombs) offer a transformative potential to reduce the complexity and size of traditional laser frequency combs. Recent advances in dis",{"id":507,"funder":7,"programme":8,"title":508,"piName":14,"institution":509,"country":169,"year":13,"amount":374,"abstract":510},"cordis-european-research-council-award-101198844","Tracing Evolutionary Pathways in Grassroots Climate Governance: Connecting Past, Present, and Future Inter-Scalar Adaptation Strategies in Southeast Asia","KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW","TRACE aims to amplify grassroots forces in climate governance to spearhead systematic transformations and just transitions. It pushes for a paradigm shift in climate governance, with Southeast Asia as a key site to adaptation strategies. Through reframing and reconceptualization of climate adaptation as geographies of knowledge, culture, and agency, TRACE will develop groundbreaking transdisciplinary concepts, frameworks, research methodologies, and tools for knowledge co-creation, power co-prod",{"id":512,"funder":7,"programme":8,"title":513,"piName":14,"institution":514,"country":355,"year":13,"amount":515,"abstract":516},"cordis-european-research-council-award-101200946","Conformal Organic Devices for Electronic Brain-gut REAdout and CharactERisation","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€2,498,444","Over 100M people in Europe live with a digestive disorder, and this number is rising. The gastrointestinal (GI) tract is a complex ecosystem which facilitates digestion and regulates food intake in addition to regulating immune function in order to effectively guard against pathogens while tolerating innocuous antigens. It also acts as a sensory organ. The GI tract is connected with the brain via neuronal and hormonal signalling pathways which form the gut-brain axis (GBA). Dysregulation of the ",{"id":518,"funder":7,"programme":8,"title":519,"piName":14,"institution":514,"country":355,"year":13,"amount":520,"abstract":521},"cordis-european-research-council-award-101200453","Bright High Spin Molecular Semiconductors","€2,499,998","BRIGHTS builds on the proposer’s discovery of high photoluminescence quantum efficiency, PLQE, from high spin states excitons (S = 1, 3\u002F2, 2) in molecular semiconductors. This is underpinned by their recent development of spin doublet molecular semiconductors where bright spin doublet excitons support efficient OLED operation, particularly for red and near-IR.  High spin molecular systems have previously been developed for their quantum properties but have been non-luminescent, preventing optica",{"id":523,"funder":7,"programme":8,"title":524,"piName":14,"institution":514,"country":355,"year":13,"amount":525,"abstract":526},"cordis-european-research-council-award-101199417","Dissecting the code for regulatory T cell entry into the tissues and differentiation into tissue-resident cells","€2,499,960","Foxp3+ regulatory T cells (Tregs) are highly potent immunosuppressive cells. Most of our understanding of Tregs is based on the population present in lymphoid tissues, however to harness their anti-inflammatory power in the clinic we need to understand the tissue-resident population. Converting generic Tregs into expanded proto-tissue Tregs, capable of entering inflamed tissues, adapting to local conditions, and driving an anti-inflammatory pro-rejuvenation process would transform cell therapy. ",{"id":528,"funder":7,"programme":8,"title":529,"piName":14,"institution":530,"country":155,"year":13,"amount":531,"abstract":532},"cordis-european-research-council-award-101201397","The Discrimination-Inequality Cycle: Bridging Unequal Treatment and Unequal Outcomes across Countries, Regions and Workplaces","FONDATION NATIONALE DES SCIENCES POLITIQUES","€2,499,511","Social science research has made impressive strides in studying discrimination (unequal treatment) and inequality (unequal outcomes), but often examines them separately. DISEQUAL bridges this gap by exploring the mutually reinforcing relations between discrimination and inequality – conceptualized as the Discrimination-Inequality Cycle. The project advances the field through three key objectives: 1) Assessing the relations between discrimination and inequality combining experimental and observat",{"id":534,"funder":7,"programme":8,"title":535,"piName":14,"institution":457,"country":148,"year":13,"amount":536,"abstract":537},"cordis-european-research-council-award-101199488","Quantifying Evolution: a platform for the synthetic evolution of molecular ecosystems.","€2,435,177","Among the fundamental processes governing Nature, evolution is one of the most thoroughlAmong the fundamental processes governing Nature, evolution is one of the most thoroughly described and less formalized. The grand goal of describing evolution via clean universal laws is made difficult by the inherent complexity of both the biological systems and the available experimental models, which generally involve a large number of potentially relevant variables of difficult quantification. This proje",{"id":539,"funder":7,"programme":8,"title":540,"piName":14,"institution":481,"country":355,"year":13,"amount":541,"abstract":542},"cordis-european-research-council-award-101197781","Unravelling the molecular determinants of insecticide sensitivity in the Hymenoptera HYMOTOX","€2,485,038","Hymenoptera (sawflies, wasps, ants, and bees) are an environmentally and economically important order of insects that carry out vital ecosystem services in their role as parasitoids, predators, and pollinators. However, while performing this function, hymenopteran species may come into contact with potentially harmful xenobiotics in the environment such as pesticides. We have recently demonstrated that the impact of pesticides on the health of managed bee species is profoundly influenced by the ",{"id":544,"funder":7,"programme":8,"title":545,"piName":14,"institution":546,"country":57,"year":13,"amount":547,"abstract":548},"cordis-european-research-council-award-101199710","Quantum Chemical Exploration of Reaction Networks: From Origins of Life to De Novo Enzyme Design","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€2,495,175","Gaining comprehensive insights into chemical and biochemical reaction networks is crucial for understanding and controlling molecular and catalytic processes; however, unraveling their intricate mechanisms remains a key challenge. QCexplore will provide a generally applicable solution to this challenge by developing an unbiased quantum-chemical reaction network exploration method and a highly efficient, fully automated open-source software framework.The starting point for these developments is o",{"id":550,"funder":7,"programme":8,"title":551,"piName":14,"institution":552,"country":355,"year":13,"amount":553,"abstract":554},"cordis-european-research-council-award-101200850","Zambezian Entanglements in the South Central African Iron Age","UNIVERSITY OF YORK","€2,813,408","ZAMBEZI introduces a radical new precolonial history of an African region in the Middle Zambezi Valley. The project explores the site of Ingombe Ilede in Zambia and its regional setting, using a nested methodology offering three levels of innovation: (1) deep understanding of a crucial but under-explored site; (2) pioneering methodologies offering unique detail on human settlement and mobility; and (3) a transformative view of the African past derived from an exploration of diversity and conting",{"id":556,"funder":7,"programme":8,"title":557,"piName":14,"institution":558,"country":97,"year":13,"amount":559,"abstract":560},"cordis-european-research-council-award-101199683","The Catholic Church and the environment.","UNIVERSIDAD DE SANTIAGO DE COMPOSTELA","€2,494,173","Fifty-six years ago, historian Lynn White Jr. published his “J’accuse” against the Judeo-Christian tradition, blaming it for fostering a culture that exploited nature. Half a century later, Pope Francis published an environmental manifesto, positioning himself as a champion against climate change. Has the Catholic Church (CC) embraced environmentalism? What have been its key environmental interventions, turning points, and internal and external frictions?CATCH will provide the first comprehensiv",{"id":562,"funder":7,"programme":8,"title":563,"piName":14,"institution":564,"country":321,"year":13,"amount":565,"abstract":566},"cordis-european-research-council-award-101200758","Phylogenetic taxonomy and classification of fungi","TARTU ULIKOOL","€3,305,750","The kingdom Fungi comprises >150,000 currently recognised species distributed across 80 classes in 20 phyla. Total species numbers are estimated at 2-3 million and our preliminary eDNA analyses suggest at least double numbers of higher-ranking taxa. However, current nomenclatural regulations fall short in DNA-based taxonomic descriptions. PhylFun aims to develop the concept and methodology for DNA-based phylogenetic classification of organisms, using fungi as examples, for an improved taxon comm",{"id":568,"funder":7,"programme":8,"title":569,"piName":14,"institution":570,"country":571,"year":13,"amount":374,"abstract":572},"cordis-european-research-council-award-101199632","Rethinking Queer Kinship:  LGBTIQ* Families with children in Central and Eastern Europe","UNIWERSYTET WARSZAWSKI","PL","The marginalization of Central and Eastern Europe in queer kinship and family studies has created a critical gap in understanding global LGBTIQ* family dynamics. Dominant theories, shaped largely by Anglo-American contexts, often overlook the diversity of family structures and practices in other regions. QUEERSHIP addresses this gap through the first transnational, interdisciplinary study of queer kinship across Poland, Hungary, Czechia, and Croatia.QUEERSHIP aims to develop the Multidimensional",{"id":574,"funder":7,"programme":8,"title":575,"piName":14,"institution":576,"country":148,"year":13,"amount":577,"abstract":578},"cordis-european-research-council-award-101199315","Discovering Mineral nAnoinclusions in DiAaMonds","UNIVERSITA DEGLI STUDI DI PADOVA","€3,499,978","Diamonds are the only geological materials able to travel hundreds of kilometres vertically, horizontally and through time for billions of years, being un-modified since the day of their formation. Not just a time capsule, when diamonds incorporate mineral inclusions captured from the deep mantle, they represent an open window into otherwise inaccessible regions of Earth. Based on their formation depths, diamonds are classified as lithospheric (formed between about 120 and 200 km depth) and subl",{"id":580,"funder":7,"programme":8,"title":581,"piName":14,"institution":582,"country":148,"year":13,"amount":583,"abstract":584},"cordis-european-research-council-award-101199997","ALK-driven cancers: a Portfolio of ONcoimmunoTherapies to achieve tumor Eradication","UNIVERSITA DEGLI STUDI DI TORINO","€2,497,392","Cancers driven by the oncogenic activation of the ALK gene include subsets of non-small cell lung cancer, lymphoma, neuroblastoma, melanoma, glioblastoma, thyroid cancer, stromal tumors and other hematologic malignancies and solid tumors. Typically, these cancers affect children or young adults in healthy conditions with a long expectancy of life. They are currently treated with ALK tyrosine kinase inhibitors (TKIs) either in first line or at relapse after other standard therapies. ALK TKIs redu",{"id":586,"funder":7,"programme":8,"title":587,"piName":14,"institution":588,"country":117,"year":13,"amount":589,"abstract":590},"cordis-european-research-council-award-101199002","Loneliness, Emotions, and Regulation: Understanding Institutions through Privacy","UNIVERSITAT WIEN","€2,499,987","LONERS addresses the growing public health and security concern of loneliness, which often leads to feelings of isolation, anxiety and despair. As loneliness becomes more prevalent in modern society, its social and political implications expand. However, loneliness can also evoke positive emotions such as calm, self-reliance and empathy, highlighting the complexity of this emotional landscape. Understanding this spectrum of emotions is crucial for addressing loneliness effectively in both indivi",{"id":592,"funder":7,"programme":8,"title":593,"piName":14,"institution":588,"country":117,"year":13,"amount":594,"abstract":595},"cordis-european-research-council-award-101200188","Windows of microbial activity in deserts afforded by non-rain water","€2,617,968","Soil microorganisms are essential drivers of ecosystem processes in drylands that cover ~40% of the Earth’s landmasses. It is widely accepted that microbial activity in arid deserts is confined to rare, short and unpredictable rain pulses. Yet, water could be available for soil microorganism by other processes, such as dew formation, fog deposition and water vapor adsorption. These so-called non-rain water inputs represent significant sources of water, as they are more frequent and reliable. Yet",{"id":597,"funder":7,"programme":8,"title":598,"piName":14,"institution":599,"country":12,"year":13,"amount":600,"abstract":601},"cordis-european-research-council-award-101201130","The Late Scholastic Transformation of Hylomorphism. Philosophical Discussions of Form and Matter in Context, 1400-1600","KATHOLIEKE UNIVERSITEIT LEUVEN","€2,498,985","TRANSFORM investigates the development of hylomorphism – the philosophical theory that every physical object is composed of structurable matter and structuring form (“hyle” and “morphe” in Greek) – in the period 1400-1600. For most of its 2500-year history, from its Aristotelian beginnings to modern-day metaphysics, hylomorphism has been a fundamental philosophical notion. From around 1200, when the works of Aristotle and his Arabic commentators were translated into Latin, hylomorphism became ce",{"id":603,"funder":7,"programme":8,"title":604,"piName":14,"institution":605,"country":117,"year":13,"amount":374,"abstract":606},"cordis-european-research-council-award-101199531","New Paradigm of Stellar Convection","UNIVERSITAET GRAZ","Tension between solar observations and theoretical and numericalmodels is shifting the paradigm of stellar convection: simulationsproduce dominant large-scale flows that are absent in the Sun and thesupergranulation scale which according to helioseismology is dominantin the Sun is not captured by simulations. This discrepancy, named theconvective conundrum, is the most likely reason why solar differentialrotation and global dynamo cannot be reproduced by currentsimulations. Canonical theory of c",{"id":608,"funder":7,"programme":8,"title":609,"piName":14,"institution":610,"country":97,"year":13,"amount":611,"abstract":612},"cordis-european-research-council-award-101200217","The End of Petroleum and the Global South - Ethnographies of Oil Extraction and Policy Futures in a Decarbonising World","UNIVERSIDAD DEL PAIS VASCO\u002F EUSKAL HERRIKO UNIBERTSITATEA","€2,496,500","S-OIL is a transregional investigation into the nature, roles and developmental footprints of national oil companies (NOCs) facing the urgency of decarbonisation and the challenges of the global energy transition. Its significance and timeliness have been highlighted by growing academic and policy debates around the resurgence of the state, changing world geopolitics and the phasing out of fossil fuels.State-owned oil companies will make or break the energy transition. To date, however, there ha",{"id":614,"funder":7,"programme":8,"title":615,"piName":14,"institution":445,"country":97,"year":13,"amount":374,"abstract":616},"cordis-european-research-council-award-101201412","Chronology of our Galaxy from Gaia Color-Magnitude Diagram fitting","The overarching goal of ChronoGal is to unveil the sequence of events and physical processes that have shaped the Milky Way (MW) from its early assembly to the present, by providing the holy grail of Galactic Archaeology (GA): precise age information. Our Galaxy is key to study disk galaxy formation and evolution, as it can be analyzed in exceptional detail using individual stars carrying the fossil record of its entire evolution. The importance of GA is underscored by the vast resources investe",{"id":618,"funder":7,"programme":8,"title":619,"piName":14,"institution":620,"country":355,"year":13,"amount":621,"abstract":622},"cordis-european-research-council-award-101199639","Decoding the Internal and External Drivers of Plant Defence Memory","THE UNIVERSITY OF SHEFFIELD","€2,498,283","Plants excel in adapting to changing environments, which relies on their ability to store and integrate information from previously encountered stresses. Without a cellular immune system or direct communication with their offspring, plants use alternative pathways to obtain defence memory and prepare their progeny against persistent threats. Biotic stress by pests and diseases triggers changes in the epigenetic makeup and root-associated microbiome of plants, resulting in a multi-faceted defence",{"id":624,"funder":7,"programme":8,"title":625,"piName":14,"institution":626,"country":57,"year":13,"amount":627,"abstract":628},"cordis-european-research-council-award-101200945","Dark Nerd Communities: A multi-method exploration of toxic degradation in the adolescent technosphere","UNIVERSITAET MUENSTER","€2,499,776","The online world of adolescent nerd communities, once a refuge for enthusiasts of digital games, technology, and fandom, has taken a troubling turn. Previously harmless niche groups have evolved into ‘dark nerd communities,’ where exclusionary ideologies, misogyny, and extremist views have taken root. Events like GamerGate and the ‘incel’ movement exposed sexism, anti-liberalism, and connections to alt-right ideologies, raising critical questions about the processes behind this shift.This resear",{"id":630,"funder":7,"programme":8,"title":631,"piName":14,"institution":570,"country":571,"year":13,"amount":632,"abstract":633},"cordis-european-research-council-award-101201542","Modeling disorder in crystalline materials using systematically improvable correlated methods","€3,500,000","This proposal aims to advance the modeling of disordered correlated-electron materials by developing novel ab-initio quantum chemistry methods that challenge the prevailing dominance of density functional theory (DFT) in this area.  By harnessing recent breakthroughs in Green's function techniques, machine learning, and advanced mathematical models, we propose a comprehensive suite of tools for predicting spectral and thermodynamic properties of disordered materials. The methods developed in thi",{"id":635,"funder":7,"programme":8,"title":636,"piName":14,"institution":582,"country":148,"year":13,"amount":637,"abstract":638},"cordis-european-research-council-award-101200424","Theorizing the Drivers of the Asylum-Far Right Nexus in Rural Europe","€2,333,063","Since 2015, mediatised episodes of protest and hostility towards refugees in rural areas in Europe have contributed to the perception of an alleged nexus between reception and the electoral success of far-right populist parties. However, despite the increasing interest of academic research, a patchy understanding of the factors and mechanisms driving the emergence of an asylum-far right nexus in rural areas persists. Whereas public opinion surveys emphasise the nationalistic orientation of rural",{"id":640,"funder":7,"programme":8,"title":641,"piName":14,"institution":642,"country":148,"year":13,"amount":643,"abstract":644},"cordis-european-research-council-award-101199314","Engineering Synthetic Gene Circuits through Competitive Dimerization.","FONDAZIONE TELETHON ETS","€2,484,115","Synthetic gene circuits offer considerable potential for engineering human cells to perform complex functions for innovative biotechnological and therapeutic applications. However, current approaches are limited by the lack of versatile, scalable and modular molecular components. DIMERCIRCUITS aims to overcome these barriers by developing a novel class of Modular Artificial Dimerizing transcription factors (MADTFs) whose activity is dynamically regulated through interaction with competitive inhi",{"id":646,"funder":7,"programme":8,"title":647,"piName":14,"institution":648,"country":117,"year":13,"amount":649,"abstract":650},"cordis-european-research-council-award-101198742","Ideology in Context: An Agential Approach to the Study of Houthism","OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN","€2,498,641","The stellar rise of the Yemen’s Houthis (Ansar Allah) is not just a story of military conquest but also of ideological innovation, which has transformed northern Yemen and reshaped power relations in the Middle East. Despite their importance, the unanswered question of what the Houthis “really” want still looms large in academic debates and political circles. This project will transform our understanding of the Houthis by analysing their massive ideological output and triangulating it with a vas",{"id":652,"funder":7,"programme":8,"title":653,"piName":14,"institution":654,"country":117,"year":13,"amount":14,"abstract":655},"cordis-european-research-council-award-101201037","Realistic modeling of unconventional superconductors","TECHNISCHE UNIVERSITAET WIEN","Feynman diagrammatic extensions of dynamical mean-field theory are powerful enough for calculating unconventional superconductivity in actual materials. As a proof of principle, we were able to predict the superconducting phase diagram,the electronic and magnetic spectra of infinite-layer nickelates - with astonishing accuracy. At the same time, a new class of finite-layer nickelates, La_n+1Ni_nO_3n+1, was discovered last year. These Ruddlesden-Popper nickelates led to a boost of scientific acti",{"id":657,"funder":7,"programme":8,"title":658,"piName":14,"institution":659,"country":50,"year":13,"amount":660,"abstract":661},"cordis-european-research-council-award-101201285","Geopolitical Struggles of the Emerging Global Tech Order","KOBENHAVNS UNIVERSITET","€2,496,638","The regulation of digital technology is central to the growing geopolitical struggles in global politics, yet we know little about how the major players themselves perceive the key points of contention. The point of departure for TECHORDER is that global tech governance is guided not just by technical expertise, profit motives, or national security concerns, but also by ideas about the transformative potential of digital technologies, which are seen as capable of bringing about both apocalyptic ",{"id":663,"funder":7,"programme":8,"title":664,"piName":14,"institution":665,"country":169,"year":13,"amount":666,"abstract":667},"cordis-european-research-council-award-101201510","Robust Generative Information Retrieval","UNIVERSITEIT VAN AMSTERDAM","€2,868,930","Generative information retrieval is an emerging paradigm that replaces the traditional index-then-retrieve pipeline by encoding all information about a document collection in the parameters of a model. The retrieval task is then formalized as a sequence-to-sequence learning problem, making it possible to optimize the system end-to-end. This enables optimization towards a broad range of goals, not just short-term utility ones but also broader long-term objectives, such as fairness and diversity.T",{"id":669,"funder":7,"programme":8,"title":670,"piName":14,"institution":665,"country":169,"year":13,"amount":671,"abstract":672},"cordis-european-research-council-award-101200477","New Foundations for Intensionality","€2,499,832","Intensional notions such as those of property, content, proof, possibility and necessity are central to philosophy, logic, mathematics and linguistics. However, these notions are threatened by paradoxes reminiscent of those that plagued the foundations of mathematics at the beginning of the XX century. And while a consensus has emerged over which shape a foundation of mathematics should take, the intensional paradoxes are still awaiting solution. Indeed, the intensional paradoxes affect the majo",{"id":674,"funder":7,"programme":8,"title":675,"piName":14,"institution":676,"country":110,"year":13,"amount":374,"abstract":677},"cordis-european-research-council-award-101199137","Genetics of long-distance migration","LUNDS UNIVERSITET","It is firmly established that the migratory behaviour of animals is largely genetically hard-wired. However, we do not know the genes involved, where these are expressed and how the genetic code guides individuals to fly in a specific direction for more than a month, across deserts, mountain ranges or oceans, to finally reach a wintering area on the other side of the globe. To approach these gaps of knowledge, I propose a coherent research program that builds on my long-term research of migrator",{"id":679,"funder":7,"programme":8,"title":680,"piName":14,"institution":681,"country":25,"year":13,"amount":682,"abstract":683},"cordis-european-research-council-award-101200557","The roadmap enabling spinal cord regeneration in mammals","I3S - INSTITUTO DE INVESTIGACAO E INOVACAO EM SAUDE DA UNIVERSIDADE DO PORTO","€2,499,963","It is widely documented that the adult mammalian central nervous system (CNS) does not regenerate. This failure results from the inhibitory scar environment and the decline of developmental growth programs. Overturning this dogma, the PI recently demonstrated that the spiny mouse (Acomys cahirinus) regenerates spontaneously the spinal cord, with robust functional recovery. Her current preliminary data support that an early switch occurs in the injured Acomys spinal cord, allowing scar reversion ",{"id":685,"funder":7,"programme":8,"title":686,"piName":14,"institution":665,"country":169,"year":13,"amount":687,"abstract":688},"cordis-european-research-council-award-101198798","Dark Matter Phenomenology in Strong Gravity","€2,499,763","A new era has come in the quest for dark matter, due to the absence of evidence for the most popular candidates, despite the enormous effort that has gone into searching for them. Here, I argue that the advent of precision gravitational wave astronomy offers a new extraordinary opportunity to discover DM in the strong gravity regime, and to uncover its particle properties. In a series of recent breakthrough studies, my team has shown that upcoming gravitational interferometers will be sensitive ",{"id":690,"funder":7,"programme":8,"title":691,"piName":14,"institution":665,"country":169,"year":13,"amount":374,"abstract":692},"cordis-european-research-council-award-101199713","COLFIN: Colonial Financial Infrastructures","COLFIN develops a new approach to understanding and responding to the colonial durabilities in modern financial infrastructures. The starting point is that the relation between finance and colonialism is infrastructural, not purely related to individual families or companies. Financial innovation co-evolved with colonial expansion and vice versa. The longer time horizons, transnational payments and novel uncertainties of colonial expansion are at the heart of modern financial innovation. Academi",{"id":694,"funder":7,"programme":8,"title":695,"piName":14,"institution":696,"country":148,"year":13,"amount":374,"abstract":697},"cordis-european-research-council-award-101198490","The LPS-code: uncovering meta-level chemical structures that establish LPS as friend or foe","UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II","The lipopolysaccharide endotoxins (LPSs) are ubiquitous microbial cell surface glycolipids of Gram-negative bacteria and are key molecular actors in the interaction with eukaryotic hosts. Traditionally, studies have focused on the role of LPS as dangerous and potent molecules with the ability to boost innate immunity in eukaryotes and cause sepsis in humans and severe pathologies in plants. In recent years, however, it has become clear that LPS is not always working as a microbial weapon. Indeed",{"id":699,"funder":7,"programme":8,"title":700,"piName":14,"institution":701,"country":110,"year":13,"amount":702,"abstract":703},"cordis-european-research-council-award-101200949","Next Generation Computer Assisted Reasoning","GOETEBORGS UNIVERSITET","€2,499,057","Galileo said that mathematics is the language of science. It is used to solve arbitrary abstract problems, underpinning hard sciences, technology and engineering. Automation of complex mathematical reasoning, discovery and large-scale formal proofs is today one of the greatest challenges in the fields of Automated Reasoning (AR) and Artificial Intelligence (AI). Compared to human experts, today’s main automated reasoning and theorem proving paradigms are severely one-sided: they largely lack the",{"id":705,"funder":7,"programme":8,"title":706,"piName":14,"institution":707,"country":155,"year":13,"amount":708,"abstract":709},"cordis-european-research-council-award-101200634","Time-Traveling Trees: Machine-reading the Past, Present, and Future of Climate Change Adaptation from Archival Aerial Photography","RESEAU FRANCAIS DES INSTITUTS D'ETUDES AVANCEES","€2,499,750","This project begins with a “book:” eight historical case studies detailing environmental change will serve to produce 8 machine learning training data sets to develop a methodology for the automatic analysis of quantitative and visual environmental data from historical aerial photographs. This will allow for a new approach to study the 1940s-1990s Great Acceleration, which caused unprecedented environmental change. Becoming ubiquitous in the 1940s, aerial photography has a sub-1-meter resolution",{"id":711,"funder":7,"programme":8,"title":712,"piName":14,"institution":713,"country":230,"year":13,"amount":714,"abstract":715},"cordis-european-research-council-award-101199496","Digital archaeology of shell companies. Infrastructures of global connections and local networks","UNIVERSITE DU LUXEMBOURG","€3,366,380","Shell companies have played a crucial role in the infrastructure of global capitalism as vehicles for tax engineering and maintaining secrecy. The challenge of finding suitable sources for a subject tied to secrecy, and a tendency to focus on national case studies for a phenomenon that transcends geographical boundaries, have hindered efforts to unravel these complex infrastructures. Building on a research initiative that focused exclusively on Luxembourg this newly proposed project adopts a glo",{"id":717,"funder":7,"programme":8,"title":718,"piName":14,"institution":719,"country":355,"year":13,"amount":720,"abstract":721},"cordis-european-research-council-award-101201604","Re-imagining Activism, Communication and Trajectories of Participation in the Global South","LOUGHBOROUGH UNIVERSITY","€2,436,327","We live in a time of endemic uncertainty and accelerating socio-economic exclusion. The collapse of the extractivist ideology of the neoliberal model of development has led to needs for other worldviews. Young people in the Global South are particularly impacted by the socio-economic consequences, affecting their ability to control their livelihoods. This is indicated by high unemployment, gender and job market inequalities, and the decline of living standards despite general economic growth.REA",{"id":723,"funder":7,"programme":8,"title":724,"piName":14,"institution":725,"country":169,"year":13,"amount":14,"abstract":726},"cordis-european-research-council-award-101200826","Aquiverse: a collaborative study of initiatives of groundwater care to re-think, improve and support its governance.","STICHTING IHE DELFT INSTITUTE FOR WATER EDUCATION","Groundwater resources are under threat from overexploitation, with nearly a third of the world’s largest aquifers being depleted faster than they can be replenished. Initiatives to curb depletion so far have been ineffective. This is because they narrowly attribute it to individual pumping behaviors without questioning the government-promoted intensification of agriculture that pushes farmers to use ever more groundwater in the first place. This project, Aquiverse, reframes groundwater governanc",{"id":728,"funder":7,"programme":8,"title":729,"piName":14,"institution":730,"country":731,"year":13,"amount":374,"abstract":732},"cordis-european-research-council-award-101199239","Livelihoods in the Platform Economy Ecosystem","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","IE","Work mediated by digital platforms – where the platform brokers labour relationships between worker and client, consumer, or other end user – has become an increasing feature of the employment landscape across Europe. Consequently, understanding the nature of this work has become an urgent need. The LivePlatforms project will develop and test a method for gathering qualitative data on the wide ecosystem that comprises platform work as a lived experience across a national context and critically a",{"id":734,"funder":7,"programme":8,"title":735,"piName":14,"institution":730,"country":731,"year":13,"amount":374,"abstract":736},"cordis-european-research-council-award-101200625","Waveforms for Extreme Mass Ratio Inspirals","The breakthrough detection of Gravitational Waves (GWs) by the LIGO-Virgo-KAGRA Collaboration (LVK) is generating waves of excitement within the physics community. The detection itself led to the award of the 2017 Nobel Prize in Physics. Even more exciting is that the first detection was only the start. LVK continues to make groundbreaking discoveries as the detector is tuned to be sensitive to ever more distant sources.The next quantum leap in GW science will come with the launch of the Laser I",{"id":738,"funder":7,"programme":8,"title":739,"piName":14,"institution":740,"country":355,"year":13,"amount":741,"abstract":742},"cordis-european-research-council-award-101201685","Expanded genetic alphabets for orthogonal encoding of genetic information","UNITED KINGDOM RESEARCH AND INNOVATION","€1,497,496","In OrthoScript, we aim to build a technology platform for the efficient synthesis, replication and evolution of DNA and RNA comprising alternative genetic alphabets that are either orthogonal to the natural alphabet or expand its combinatorial potential and information density. Our approach involves the leveraging of protein design and evolution approaches to generate bespoke DNA and RNA polymerase enzymes for the encoded synthesis and sequencing of expanded genetic alphabets with high efficienc",{"id":744,"funder":7,"programme":8,"title":745,"piName":14,"institution":514,"country":355,"year":13,"amount":746,"abstract":747},"cordis-european-research-council-award-101199822","Discovering the circuit and molecular basis of inter-strain and inter-species differences in learning","€2,749,321","Across the animal kingdom, closely-related species can differ in their learning ability, as can differentindividuals of the same species, but the underlying causes of these differences are poorly understood.Differences in learning could be due to different structural and functional properties of learning circuits whichin turn result from different patterns of gene expression. However, identifying homologous learning circuitneurons in different species for comparing their synaptic connectivity, c",{"id":749,"funder":7,"programme":8,"title":750,"piName":14,"institution":751,"country":97,"year":13,"amount":752,"abstract":753},"cordis-european-research-council-award-101200655","Disruptive Economies and Macrolithic Technologies in the Euro-Mediterranean Bronze Age","UNIVERSITAT AUTONOMA DE BARCELONA","€2,498,791","Between 3000 and 1500 BCE, a relatively small number of Mediterranean and European societies underwent deep changes, leading tolarge-scale, centralised, and highly unequal economic and political entities. Most of these Early Bronze Age “innovative regions” areidentified with the rise of a warrior elite or aristocracy, craft specialisation, agricultural intensification, and expanding exchangenetworks. What caused the rapid emergence and, centuries later, sudden collapse of these “disruptive socie",{"id":755,"funder":7,"programme":8,"title":756,"piName":14,"institution":757,"country":355,"year":13,"amount":758,"abstract":759},"cordis-european-research-council-award-101200121","Circular Light-Based 3D Printable Lipoate-based Polymers","THE UNIVERSITY OF BIRMINGHAM","€2,499,711","The high speed and accuracy of photopolymer additive manufacturing methods are enabling the transition of their use from prototyping to production. While these manufacturing methods have advanced significantly over recent years, this has not been matched by developments in photopolymer resin technology, which remains based on petrochemical sourced materials and produces waste that cannot be recycled. CIRCLIPO will deliver high modulus, photocurable polymers for application in production scale ci",{"id":761,"funder":7,"programme":8,"title":762,"piName":14,"institution":763,"country":169,"year":13,"amount":764,"abstract":765},"cordis-european-research-council-award-101198944","The role of microbes in the fate of nanoplastics in the marine realm","STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN","€3,499,999","Nanoplastics (plastic litter fragments \u003C1µm) were only recently discovered in the marine realm. Due to their colloidal nature, nanoplastics may be dispersed throughout the ocean, potentially affecting all marine life. However, their minuscule size has made it virtually impossible to measure their distribution or determine if microbes can degrade nanoplastics, thus influencing their fate in the ocean. Innovative approaches developed by my team have now made this possible for the first time. Using",{"id":767,"funder":7,"programme":8,"title":768,"piName":14,"institution":769,"country":355,"year":13,"amount":14,"abstract":770},"cordis-european-research-council-award-101200737","Single-protein mechanochemical regulation of cell function","KING'S COLLEGE LONDON","Mechanical stimuli regulate an increasingly large number of cellular and tissue functions. However, the effect that those macroscopic forces have on the underpinning proteins is poorly understood.Most of our knowledge of protein dynamics under force is still restricted to in vitro single-molecule experiments. Collectively, these molecular measurements have revealed that, when denatured with force, proteins unfold and stretch along their end-to-end length, following a completely different pathway",{"id":772,"funder":7,"programme":8,"title":773,"piName":14,"institution":348,"country":57,"year":13,"amount":774,"abstract":775},"cordis-european-research-council-award-101201575","Surveillance of Translation: From Molecular Mechanisms to Roles in Disease","€2,499,925","Proteostasis is a dynamic network integrating protein biogenesis, folding, trafficking, and degradation to build a functional proteome. Disrupted proteostasis resulting the accumulation and aggregation of aberrant proteins in neurons is a hallmark of neurodegenerative diseases. This project’s overall goal is to uncover molecular mechanisms that maintain proteostasis and protect against neurodegeneration, by taking a fresh look at these processes through the lens of Ribosome-associated Quality Co",{"id":777,"funder":7,"programme":8,"title":778,"piName":14,"institution":122,"country":110,"year":13,"amount":779,"abstract":780},"cordis-european-research-council-award-101200001","The early sequestered germline of fungi - spatial distribution, mechanism and generality across the kingdom","€2,497,523","The FunGerm-project aims to investigate the phenomenon of an early sequestered germline in the fungi. As of today, it is well known that in unitary animals the germline is defined early during development, while in fungi, plants, and other metazoans, the current dogma is that the germline is defined much later in development, meaning that mutations that have accumulated over growth can enter the germline. Recent, and yet unpublished, whole-genome-sequencing data in my group show the unexpected p",{"id":782,"funder":7,"programme":8,"title":783,"piName":14,"institution":784,"country":117,"year":13,"amount":785,"abstract":786},"cordis-european-research-council-award-101199958","The Nuclear Pore Complex: Bridging Membrane Remodelling and Lipid Metabolism","MEDIZINISCHE UNIVERSITAET WIEN","€2,499,250","The nuclear pore complex (NPC) is a defining component of eukaryotic cells. Its role as a selective transport channel is well-documented, but NPCs also remodel the nuclear envelope, bending and fusing the inner and outer nuclear membranes to form a pore without rupturing the cell nucleus. The underlying mechanism of this process is poorly understood, despite its profound implications for cellular function. My proposal addresses how nuclear pore complexes function as membrane remodelling machines",{"id":788,"funder":7,"programme":8,"title":789,"piName":14,"institution":514,"country":355,"year":13,"amount":790,"abstract":791},"cordis-european-research-council-award-101200246","The energy-converting mechanism of a modular biomachine: Uniting structure and function to establish the engineering principles of respiratory complex I","€2,444,452","Complex I (NADH:ubiquinone oxidoreductase), one of the largest membrane-bound enzymes in the mammalian cell, uses the reducing potential of NADH to drive protons across the inner mitochondrial membrane and power ATP synthesis. It is a keystone of metabolism, crucial for survival of human cells, and a primary site of mitochondrial dysfunctions and clinical disease. Complex I is also an efficient energy-converting biomachine, which shares conserved subunits, a molecular architecture, and modular d",{"id":793,"funder":7,"programme":8,"title":794,"piName":14,"institution":795,"country":169,"year":13,"amount":796,"abstract":797},"cordis-european-research-council-award-101200545","Autonomic Balance for Adaptive Decision Making","STICHTING RADBOUD UNIVERSITEIT","€2,499,999","Why do some people make highly flexible approach-avoid decisions under threat, while others can only follow fight-flight impulses? Computational psychiatry has advanced formalizations on how utility functions shape optimal decisions. But decisions are made by embodied agents, equipped with potent and competing autonomic arousal systems: Approach-avoidance conflicts elicit stress and are marked by concurrent sympathetic and parasympathetic arousal. The impact of para- and sympathetic dominance on",{"id":799,"funder":7,"programme":8,"title":800,"piName":14,"institution":801,"country":169,"year":13,"amount":802,"abstract":803},"cordis-european-research-council-award-101201150","Deciphering the building blocks of rocky planets using JWST spectra of planet forming disks","RIJKSUNIVERSITEIT GRONINGEN","€2,498,632","The James Webb Space Telescope (JWST) now peers for the first time into the rocky planet birth environments around Solar-type (T Tauri - TT) and Very Low Mass stars (VLMS) with ages of 1-4 Myr. The data shows that disk gas around TT stars is oxygen-rich, while it is carbon-rich around VLMS; yet they formed inside the same molecular cloud. VLMS are the most abundant stars in the galaxy, hosting most rocky exoplanets known to date, making them key targets to search for life. Yet today, it is param",{"id":805,"funder":7,"programme":8,"title":806,"piName":14,"institution":807,"country":355,"year":13,"amount":808,"abstract":809},"cordis-european-research-council-award-101198886","Cultures of Joy in the Metacrisis: Resistance, Resilience, and Repair in Troubled Times","UNIVERSITY COLLEGE LONDON","€2,546,930","Joy is rarely the focus of the social sciences but is arguably more important than it has ever been. While crisis might be a ‘structural signature of modernity’ the experience of crisis today is characterised by complex systems themselves in crisis, interacting with each other in unpredictable ways. This ‘metacrisis’ is ubiquitous, enduring, and emotionally exhausting. Yet, for people around the world, living in and through the metacrisis requires joy to sustain them: experiences of joyous self-",{"id":811,"funder":7,"programme":8,"title":812,"piName":14,"institution":813,"country":57,"year":13,"amount":814,"abstract":815},"cordis-european-research-council-award-101201356","Ultrafast All-Electron Microscopy","UNIVERSITAT KONSTANZ","€3,159,425","Atoms and electrons are the central building blocks of almost all materials around us. Whenever there is a process or change, the atoms and the electrons have to move from initial to final configurations. These movements are very fast and very small: nanometers to picometers in space and femtoseconds to attoseconds in time. Ultrafast electron microscopy can provide a movie-like access, but we can only see processes that are excited by special laser light, although many reaction phenomena in natu",{"id":817,"funder":7,"programme":8,"title":818,"piName":14,"institution":819,"country":355,"year":13,"amount":820,"abstract":821},"cordis-european-research-council-award-101201656","BodyElectric: Unlocking the Potential of Electrotactile Haptics","UNIVERSITY OF GLASGOW","€2,499,820","BodyElectric will develop a new form of haptics using electrotactile stimulation to transform our ability to incorporate tactile feedback into everyday products, to create richer interactive experiences, with lower environmental cost.Tactile haptics is a key feature of many devices, from phones to in-car user interfaces, significantly improving usability and user experience. However, touch is limited to vibration. Vibration actuators are bulky, low bandwidth, use non-sustainable materials, and o",{"id":823,"funder":7,"programme":8,"title":824,"piName":14,"institution":769,"country":355,"year":13,"amount":825,"abstract":826},"cordis-european-research-council-award-101199185","New Christian Materiality, 1450-1750","€2,497,781","New Christian Materiality, 1450-1750. The New Christian trading elite, descending from Jewish communities forced to convert between 1391 and 1498 in Iberia, was at the forefront of intercontinental trade from the late fifteenth to the early eighteenth centuries. They became experts on material culture, sourced commodities from different continents, and developed markets. This project will answer the question: how did New Christian expertise in material culture influence patterns of consumption w",{"id":828,"funder":7,"programme":8,"title":829,"piName":14,"institution":509,"country":169,"year":13,"amount":374,"abstract":830},"cordis-european-research-council-award-101200066","Shaping up for mitosis: the origins and consequences of the 3D structure of mitotic centromeres","The centre of the iconic X-shape of human chromosomes is the centromere. It is an extensive locus of specialised chromatin that assembles the kinetochore machinery to connect chromosomes to spindle microtubules for their correct segregation during cell division. How these centromeres obtain three-dimensional (3D) structures that coordinate assembly of kinetochores and resist substantial microtubule-based pulling forces is unknown. We discovered that vertebrate chromosomes are naturally dicentric",{"id":832,"funder":7,"programme":8,"title":833,"piName":14,"institution":834,"country":57,"year":13,"amount":835,"abstract":836},"cordis-european-research-council-award-101198689","Equilibrium Learning, Uncertainty, and Dynamics: Novel Approaches for Analyzing Games and Automated Markets","TECHNISCHE UNIVERSITAET MUENCHEN","€1,539,750","Game theory is essential for studying central problems in economics and management such as auctions, contests, oligopoly, and platform competition. However, deriving equilibrium strategies in such games with incomplete information is notoriously challenging. For instance, analytical solutions are available only for simple auction models under restrictive assumptions. The lack of numerical methods for solving equilibrium problems impedes advancements in theory and practice. Building on insights f",{"id":838,"funder":7,"programme":8,"title":839,"piName":14,"institution":840,"country":355,"year":13,"amount":841,"abstract":842},"cordis-european-research-council-award-101200596","High-dimensional probability in ergodic theory and representation theory","UNIVERSITY OF WARWICK","€2,497,037","This project begins with the interaction between (i) convergence and limits for labeled bounded-degree graphs and (ii) the This project begins with the interaction between (i) convergence and limits for labeled bounded-degree graphs and (ii) the ergodic theory of possible limit processes over infinite graphs, regarded as stationary processes for infinite groups of symmetries. It will deliberately focus on foundational issues that cannot be addressed using the most standard tools: models that are",{"id":844,"funder":7,"programme":8,"title":845,"piName":14,"institution":846,"country":571,"year":13,"amount":847,"abstract":848},"cordis-european-research-council-award-101201303","Voices from the Deep South: the rise of Pattu song cultures of South Asia","UNIWERSYTET JAGIELLONSKI","€2,497,600","VOICES offers a new, large-scale perspective on the history of song-performing cultures of South India in premodern and colonial contexts. More than a song, pattu stands for a multitude of interrelated constellations of song traditions - a galaxy of regional song cultures. One region alone (Kerala) boasts nearly eighty song genres, many of epic proportions: from songs of heroes and place through verses to awake a deity or activate a curse, to songs of ecstatic praise.  Most are embedded in recur",{"id":850,"funder":7,"programme":8,"title":851,"piName":14,"institution":676,"country":110,"year":13,"amount":374,"abstract":852},"cordis-european-research-council-award-101199738","Dual Control at Scale: Learning-based control for systems with millions of states.","In recent years, data-driven control in high dimensions has penetrated into many new application areas. Examples include control of autonomous vehicles based on video data, simulation based prediction of turbulent flows and precision medicine based on gene sequencing time series data. Large data sets come with significant computational challenges. Tremendous algorithmic progress has been made in machine learning and related areas, but application to dynamical systems is hampered when the number ",{"id":854,"funder":7,"programme":8,"title":855,"piName":14,"institution":834,"country":57,"year":13,"amount":856,"abstract":857},"cordis-european-research-council-award-101198055","Nonlinear Evolutions and Iterative Algorithms: Optimization and Control","€2,086,498","Iterative algorithms (IA) stand as the very backbone of scientific computing. Traditional IA rely on convex optimization to guide the search for optima, severely limiting their scope to local solutions. Consequently, nonconvex problems are regarded as the ultimate challenge of global optimization. Solving them with convergence guarantees will lead to numerous scientific discoveries, such as finding new medications through optimization of the properties of molecules or enhancing materials for sol",{"id":859,"funder":7,"programme":8,"title":860,"piName":14,"institution":861,"country":57,"year":13,"amount":862,"abstract":863},"cordis-european-research-council-award-101200564","When antimatter meets strangeness: a new era for precision hypernuclear physics","TECHNISCHE UNIVERSITAT DARMSTADT","€2,954,030","Observable hadronic matter is mostly composed of u, d quarks. The strangeness degree of freedom is expected to play an important role in dense nuclear matter in the form of hyperons, baryons with at least one valence strange quark. Hyperons can form bound nuclear systemswith nucleons and create short-lived hypernuclei which decay on the time-scale of the weak interaction (typically ∼200 ps). Our knowledge of nuclear matter is so far restricted to precision nucleon scattering and nuclear data whi",{"id":865,"funder":7,"programme":8,"title":866,"piName":14,"institution":867,"country":50,"year":13,"amount":868,"abstract":869},"cordis-european-research-council-award-101198789","Nuclear RNA Sorting","AARHUS UNIVERSITET","€2,499,988","Mammalian genomes are hyperactively transcribed and, paradoxically, a major part of the produced RNA is turned over soon after its synthesis. But the situation is even more bizarre. This is because individual transcription units (TUs), that generate standard functional transcripts, also give rise to a flock of shorter labile isoforms. Overall, this presents an extraordinarily chaotic situation where the expression of functional RNA, both at the genomic- and at the single TU-level, is embedded wi",{"id":871,"funder":7,"programme":8,"title":872,"piName":14,"institution":867,"country":50,"year":13,"amount":873,"abstract":874},"cordis-european-research-council-award-101199772","Random dynamics and Geometric analysis","€2,469,703","I propose a project in mathematics on the theory of stochastic processes and their applications. I am particularly interested in the interactions between certain random dynamics and the geometry of the space on which they are defined. The focus will be on three parallel ambitious research directions:(i) Stochastic partial differential equations on fractals, with a focus on the stochastic heat equation and the parabolic Anderson model;(ii) Diffusion methods in sub-Riemannian geometry with a focus",{"id":876,"funder":7,"programme":8,"title":877,"piName":14,"institution":819,"country":355,"year":13,"amount":878,"abstract":879},"cordis-european-research-council-award-101200478","The human hippocampus as a complementary indexing machine for episodic memory","€2,499,912","Episodic memories make us who we are, yet how these memories are coded in the human brain remains an open question. We know that the human hippocampus is essential for turning unique experiences into memory episodes, such as a memory from the last concert you have attended. We also know that the human hippocampus has two types of neurons that could be critical for coding such episodic memories. These are Concept Cells, which store general semantic concepts (i.e. the artist, or the location where",{"id":881,"funder":7,"programme":8,"title":882,"piName":14,"institution":883,"country":148,"year":13,"amount":884,"abstract":885},"cordis-european-research-council-award-101199648","Satellite imaging swarms with distributed onboard intelligence","POLITECNICO DI TORINO","€3,008,550","Space-based monitoring systems for Earth observation are being increasingly employed by industry and governments, and large constellations having tens to hundreds of units will be deployed in the near future. This project considers swarms of satellites in formation flight, and it investigates innovative cooperation modalities to enhance image quality and enable satellite distributed onboard inference. Through artificial intelligence (AI), multiple simultaneous and redundant satellite image acqui",{"id":887,"funder":7,"programme":8,"title":888,"piName":14,"institution":889,"country":464,"year":13,"amount":890,"abstract":891},"cordis-european-research-council-award-101200261","Pushing the Limit of Aerosol Nanoscale Engineering with Tiny nanoparticles","NATIONAL CENTER FOR SCIENTIFIC RESEARCH DEMOKRITOS\"","€3,498,333","In gas-phase manufacture of materials as well as in the atmosphere, the interaction between gas molecules and tiny nanoparticles (TNPs, i.e. particles having sizes from ca. 0.5 to 5 nm) determines their characteristics. These are crucial for the environment impact (climate, air quality and visibility) of TNPs and their performance in engineering and life science applications. Will two molecules collide and go their ways or stick to form a TNP that will grow to a nanoparticle (NP; i.e., a particl",{"id":893,"funder":7,"programme":8,"title":894,"piName":14,"institution":514,"country":355,"year":13,"amount":895,"abstract":896},"cordis-european-research-council-award-101199598","Reprogramming lung epithelial cell lineages for regeneration","€2,499,986","In chronic adult lung diseases both tissue homeostasis and repair are disrupted, regeneration mechanisms fail, and healthy cells are replaced with aberrant cells. My long-term vision is to overcome these problems in patients with early-stage lung disease by in vivo reprogramming of cell fate to induce regeneration and restore cellular homeostasis. To achieve this we will move beyond the current state-of-the-art for human lung cell culture and human lineage-tracing, employing new physiologically-",{"id":898,"funder":7,"programme":8,"title":899,"piName":14,"institution":900,"country":355,"year":13,"amount":901,"abstract":902},"cordis-european-research-council-award-101199636","Calving Law for Ice-Climate Simulations","THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS","€2,489,721","Global sea levels will continue to rise as ice sheets shrink in response to climate change, but predictions vary widely on how much ice will be lost in different carbon futures. The single largest source of uncertainty is iceberg calving rates. Calving can cause more rapid ice loss than any other process, but no reliable method currently exists for representing calving in numerical models. CALIX seeks to find and apply the elusive universal calving law, by adopting a radical new approach based o",{"id":904,"funder":7,"programme":8,"title":905,"piName":14,"institution":906,"country":355,"year":13,"amount":907,"abstract":908},"cordis-european-research-council-award-101199569","Gesius’ Commentaries on Galen: Recovering lost works through a mixed-method approach","THE UNIVERSITY OF MANCHESTER","€2,499,869","Palimpsests have yielded spectacular new discoveries in the area of ancient texts: hitherto lost works are recovered and can be read again. We recently identified a set of five palimpsests which will radically change the way in which we view the history of medicine in late antique Alexandria and the transmission of medical knowledge from Greek via Syriac into Arabic. These palimpsests contain Commentaries by Gesius (ca. 450–530s) in Syriac translation on two works by the famous Greek physician G",{"id":910,"funder":7,"programme":8,"title":911,"piName":14,"institution":807,"country":355,"year":13,"amount":912,"abstract":913},"cordis-european-research-council-award-101200179","SocBond – the mechanisms and behaviours that create friendship","€2,116,997","Friendship is a bidirectional affiliative bond that helps people live longer healthier lives, while loneliness is linked to poor physical and mental health.  SocBond is a large-scale investigation of the brain, behavioural and cognitive mechanisms that build social connections.  Studies of whether two people will become friends suggest that synchrony (moving together), homophily (similarity of culture and cognition), and task (opportunities to coordinate and share ideas) are the three strongest ",{"id":915,"funder":7,"programme":8,"title":916,"piName":14,"institution":917,"country":148,"year":13,"amount":918,"abstract":919},"cordis-european-research-council-award-101200219","Democratic Administration under Illiberal Rule: Impact, Resistance, Resilience","EUROPEAN UNIVERSITY INSTITUTE","€2,422,908","LIBRAD investigates how populists in government reshape executive governance to implement illiberal policy changes. By covertly manipulating the machinery of government, populists erode pluralistic standards, reduce accountability, and politicize the civil service to advance their illiberal agenda.Bureaucrats play a crucial role in this context. Populists both fear them as potential saboteurs of their ambitions and simultaneously need to rely on them to push their agenda.To systematically examin",{"id":921,"funder":7,"programme":8,"title":922,"piName":14,"institution":923,"country":57,"year":13,"amount":924,"abstract":925},"cordis-european-research-council-award-101200307","Repository-wide screening for bioactivity and protein binding  using small molecule mass spectrometry data","FRIEDRICH-SCHILLER-UNIVERSITÄT JENA","€3,010,356","Bioactivity and ligand binding remain central topics for understanding protein function, for drug discovery and toxicology. Mass spectrometry (MS) allows to detect thousands of small molecules in a biological sample with a single experimental run. Compound annotation is carried out using tandem MS. I will develop machine learning models that predict whether a query small molecule has a certain bioactivity or is binding to a certain protein, where the only information we have about the query mole",{"id":927,"funder":7,"programme":8,"title":928,"piName":14,"institution":433,"country":117,"year":13,"amount":929,"abstract":930},"cordis-european-research-council-award-101201645","Molecularly informed dense connectomic mapping of mammalian brain tissue","€2,843,750","Complex wiring between neurons underlies the information processing network enabling all brain function. Fundamental questions on how the network is organized, how structural connectivity relates to the cells’ molecular machineries and how cells, synaptic connections, and circuits evolve over time remain enigmatic. Addressing these questions is beyond the limits of current measurement technologies, as these either lack resolving power to untangle cellular connectivity or can’t visualize the mole",{"id":932,"funder":7,"programme":8,"title":933,"piName":14,"institution":934,"country":57,"year":13,"amount":935,"abstract":936},"cordis-european-research-council-award-101198426","B cell-orchestrated tolerization of T cell-dependent B cell-mediated autoimmune diseases","KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)","€2,373,592","Failure of thymic tolerance may result in severe autoimmune diseases that target the central nervous system (CNS), including Multiple Sclerosis (MS), Myelin Oligodendrocyte Glycoprotein (MOG)-associated Disease (MOGAD), and Neuromyelitis Optica Spectrum Disorders (NMOSD). Recently, we discovered a new layer of thymic tolerance in that thymic B cells get licensed to present activation-induced autoantigens, among them AQP4 (the target antigen in NMOSD). Thymic B cells are necessary and sufficient ",{"id":938,"funder":7,"programme":8,"title":939,"piName":14,"institution":940,"country":321,"year":13,"amount":374,"abstract":941},"cordis-european-research-council-award-101200759","Enhanced productivity of resurrection photosynthetic organisms in a CO2-richer future: tipping the global carbon and oxidant balance","EESTI MAAULIKOOL","Terrestrial resurrection cryptogams, including mosses, lichens, algal and cyanobacterial films and crusts, are conspicuous photosynthetic organisms growing on soil, rocks, plants and artificial surfaces. They dominate multiple ecosystems worldwide, but the estimates of cryptogam share in global productivity are uncertain and the impact of climate change on their contribution to global carbon sink is unknown. Several cryptogams are strong emitters of organic volatiles, and due to huge surface are",{"id":943,"funder":7,"programme":8,"title":944,"piName":14,"institution":945,"country":57,"year":13,"amount":374,"abstract":946},"cordis-european-research-council-award-101198395","Heavy Ion FLASH","GSI HELMHOLTZZENTRUM FUR SCHWERIONENFORSCHUNG GMBH","Charged particle therapy is generally acknowledged as the most advanced type of radiotherapy (RT). Particle therapy patients are treated either with high-energy protons or 12C-ions, but there is a general agreement that heavier ions would be highly beneficial in treating extremely resistant, hypoxic and lethal tumors, such as glioblastoma (GBM). Unfortunately, the use of very heavy ions is constrained by their excessive normal tissue toxicity.A way to enable very heavy ion therapy with acceptabl",{"id":948,"funder":7,"programme":8,"title":949,"piName":14,"institution":950,"country":57,"year":13,"amount":14,"abstract":951},"cordis-european-research-council-award-101200605","Subalternity in Early Egypt (2700-2200 BC)","UNIVERSITAT ZU KOLN","Egyptology has traditionally focused on the texts, monuments, and grandiose trappings of social inequality. A substantial body of archaeological evidence for low-status groups has accumulated but is marginalized in interpretations, so a holistic view of ancient Egyptian society remains obscure. SUBALTERNEGY inverts the elite bias in Egyptology, using fresh data and an innovative theoretical framework to explore how subaltern communities responded to hegemonic concepts that emerged during the ear",{"id":953,"funder":7,"programme":8,"title":954,"piName":14,"institution":955,"country":57,"year":13,"amount":374,"abstract":956},"cordis-european-research-council-award-101199921","Supramolecular Approach to Schwarzite Carbon Materials","JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG","Considerable progress has been made over the past thirty years in the synthesis and preparation of 0D, 1D, and 2D sp2-hybridized carbon materials, as well as for their smaller discrete nanosized polycyclic aromatic hydrocarbon (PAH) counterparts. However, 3D sp2-hybridized carbon networks, called schwarzite carbons or Mackay-Terrones crystals – first proposed in the early 1990s – remain elusive, despite exciting electronic properties and important applications being predicted for these porous cr",{"id":958,"funder":7,"programme":8,"title":959,"piName":14,"institution":960,"country":169,"year":13,"amount":961,"abstract":962},"cordis-european-research-council-award-101199517","Microfluidic platform for cancer Intravasation: pass or no pass?","TECHNISCHE UNIVERSITEIT EINDHOVEN","€3,123,287","Cancer still is one of the world’s deadliest diseases.  Most devastating is the ability of cancer cells to spread throughout the body in a multistep process called metastasis, the major cause for mortality. A critical step is intravasation, when cancer cells pass a blood vessel wall to enter the blood stream, and travel to another location to create a secondary tumor. However, the mechanisms of intravasation are still largely unexplored, even though it is pivotal: if we can prevent it, cancer do",{"id":964,"funder":7,"programme":8,"title":965,"piName":14,"institution":966,"country":148,"year":13,"amount":967,"abstract":968},"cordis-european-research-council-award-101199451","Quantum fields in and out of equilibrium via spinor Bose-Einstein condensates","UNIVERSITA DEGLI STUDI DI TRENTO","€2,498,250","Our understanding of the physical world, from cosmological distances to subatomic scales, is based on field theories, with General Relativity and the Standard Model among the most validated descriptions of reality. Despite their history of success, the application of field theories, particularly in the quantum domain, is still characterized by a rich set of open questions related to processes in- and out-of-equilibrium.A paradigmatic example of a process in which field theories are successfully ",{"id":970,"funder":7,"programme":8,"title":971,"piName":14,"institution":972,"country":148,"year":13,"amount":973,"abstract":974},"cordis-european-research-council-award-101199846","Engineering the immune response in Parkinson’s disease  to curb its pathological progression","CONSIGLIO NAZIONALE DELLE RICERCHE","€2,493,000","Mounting evidence has defined the key role played by the immune system in exacerbating dopaminergic neuron loss in Parkinson’s disease (PD). Pathological alpha-Synuclein (αSYN) activates microglia and recruits inflamed T cells, creating a toxic environment that directly negatively impact on neurodegenerative processes. Blocking or attenuating neuroinflammation can have a strong therapeutic potential in PD, but systemic treatments are associated with immune system general suppression leading to s",{"id":976,"funder":7,"programme":8,"title":977,"piName":14,"institution":978,"country":148,"year":13,"amount":979,"abstract":980},"cordis-european-research-council-award-101200403","Forecasting and understanding the seIsmic cycle through b-value","UNIVERSITA DI PISA","€2,180,831","Seismology is a branch of science with many open questions, and predicting earthquakes is still a utopia. We know earthquakes interact with each other by changing the state of stress in their surroundings. Strong earthquakes are, for example, followed by countless smaller events, a posteriori called aftershocks, whose number decays with time. We have shown that aftershock sequences are systematically associated with changes in the average earthquake size distribution,  an increase in the so-call",{"id":982,"funder":7,"programme":8,"title":983,"piName":14,"institution":978,"country":148,"year":13,"amount":984,"abstract":985},"cordis-european-research-council-award-101199573","Guidance of axonal pathfinding via nano-switches","€2,440,000","Axon navigation is guided by spatial patterns of chemical and physical cues in the developing brain. After a damage, the pattern is lost. Axons do not have instructions to reach their target. Axon regeneration, if stimulated, occurs by chance. Unfortunately, current technologies do not allow us to control axon navigation decisions, and guided re-innervation is not possible in the central nervous system (CNS). The GAP project aims to fill this knowledge gap by modulating neuron mechanotransductio",{"id":987,"funder":7,"programme":8,"title":988,"piName":14,"institution":972,"country":148,"year":13,"amount":989,"abstract":990},"cordis-european-research-council-award-101198634","NanOengineering cutting-edge micro-Devices in the far-infrared through advanced material Embedding","€2,499,640","Artificial semiconductor heterostructures played a pivotal role in modern optoelectronic technologies, providing a highly effective platform for the generation of light across the mid-infrared (3-25um wavelengths) and Terahertz frequency ranges (50-250um). However, their challenging quantum engineering also limited their adoption in a spectral region (25-50um) still unexplored, and their use in frontier domains as integrated photonics and quantum science.NODE aims to intersect two materials plat",{"id":992,"funder":7,"programme":8,"title":993,"piName":14,"institution":994,"country":155,"year":13,"amount":995,"abstract":996},"cordis-european-research-council-award-101201785","Unveiling organomineral associations at the nanoscale by bridging their structure and dynamics","INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT","€2,499,875","The NANOCLICS project will demonstrate that metallic polymers of just a few atoms linked to organic molecules are the pivotal organomineral association structures in soils. They form an hydrated gel nanostructure called nanoCLICs. The project will: 1) explore their structure at the nanoscale in 10 soil types; 2) elucidate the nanoCLICs dynamics; and 3) quantify their contribution to soil carbon sequestration. The project will rely on the nanoCLICs molecular model that I previously developed.Orga",{"id":998,"funder":7,"programme":8,"title":999,"piName":14,"institution":1000,"country":97,"year":13,"amount":802,"abstract":1001},"cordis-european-research-council-award-101199778","Christians among Muslims: Monasticism in early Islamic al-Andalus (8th-11th Centuries)","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","In recent decades, the archaeological and written records have been mobilised to update our knowledge of early Islamic al-Andalus and the subsequent transformation that the arrival of Islam brought about in the Iberian Peninsula from 711 onwards. This historiographical renewal has hardly affected however the study of Christian monasticism in al-Andalus after this defining moment during the early Islamic period (8th-11th c.). This project aims at providing a step-change in the way in which this p",{"id":1003,"funder":7,"programme":8,"title":1004,"piName":14,"institution":1005,"country":355,"year":13,"amount":1006,"abstract":1007},"cordis-european-research-council-award-101201582","Sympathetic Neural Networks protecting against Obesity","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€2,612,128","The brain regulates various physiological functions, including body weight, through descending autonomic sympathetic neurons. While targeting this system can improve obesity, it often carries cardiovascular risks. These limitations arise from a limited understanding of sympathetic neural networks due to their complexity and anatomically inaccessible location. My laboratory has been developing innovative strategies, including a novel imaging technique with single-neuron resolution and advanced si",{"id":1009,"funder":7,"programme":8,"title":1010,"piName":14,"institution":1005,"country":355,"year":13,"amount":14,"abstract":1011},"cordis-european-research-council-award-101201241","Understanding outer membrane protein biogenesis in Bacteroidota bacteria","Gram-negative bacteria are distinguished by the presence of an outer membrane (OM) at the cell periphery. This membrane is the site at which the bacterium interacts with its environment (or host if a pathogen), and provides the first line of defence against antibiotics, mechanical stresses, and immunological attacks. These functions depend on the presence of proteins that either span the outer membrane (Outer Membrane Proteins, or OMPs) or are anchored to the membrane by a lipid tail (lipoprotei",{"id":1013,"funder":7,"programme":8,"title":1014,"piName":14,"institution":1005,"country":355,"year":13,"amount":1015,"abstract":1016},"cordis-european-research-council-award-101201339","Meta-complexity: A Unified Approach to the Complexity of Proofs and Computation","€2,454,938","One of the most fundamental questions in computer science is the P vs NP question, which asks if every computational problem with efficiently verifiable solutions is efficiently solvable. Equivalently, it asks if all propositional tautologies have proofs that can be found efficiently. The answer is widely believed to be negative, but we lack a rigorous justification for this belief. The field of computational complexity approaches P vs NP and related questions by showing lower bounds (i.e., impo",{"id":1018,"funder":7,"programme":8,"title":1019,"piName":14,"institution":1005,"country":355,"year":13,"amount":1020,"abstract":1021},"cordis-european-research-council-award-101201249","Sculpting cerebellar activity across timescales","€2,499,541","Long-term memories are consolidated over time, progressively becoming more stable and resistant to interference. The consolidation of motor memories is particularly robust – so much so that we use the term “like riding a bike” to describe things that we never forget. And yet, compared to declarative memory systems, relatively little is known about the neural mechanisms through which motor memories are consolidated in the brain. Several forms of motor learning require the cerebellum, a brain area",{"id":1023,"funder":7,"programme":8,"title":1024,"piName":14,"institution":348,"country":57,"year":13,"amount":1025,"abstract":1026},"cordis-european-research-council-award-101201252","Electron Capture in Ho-163 - Large Experiment","€2,431,617","The discovery of the neutrino mass scale is a milestone for shaping the extension of the Standard Model of Particle Physics. Experiments looking at the endpoint region of low energy beta decay and electron capture spectra benefit from a clear signature of massive neutrinos which only depends on energy and momentum conservation. Along with the well-established use of tritium, as in the KATRIN experiment where the present best limit of 0.45 eV at 95% CL was reached, two collaborations, ECHo and HO",{"id":1028,"funder":7,"programme":8,"title":1029,"piName":14,"institution":1030,"country":148,"year":13,"amount":1031,"abstract":1032},"cordis-european-research-council-award-101200080","Electronic Doping of Soft Semiconductors","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","€3,104,687","EDO will develop protocols for intentional, spatially controlled, and stable electronic doping in metal halide semiconductors.Electronic doping implies engineering of carrier density in semiconductors through the intentional introduction of a defect and it is necessary to achieve high performances in micro and optoelectronic technologies. Unlike established semiconductors, which are typically covalent solids, those belonging to the class of soft materials, such as molecules and polymers, forming",{"id":1034,"funder":7,"programme":8,"title":1035,"piName":14,"institution":1036,"country":97,"year":13,"amount":1037,"abstract":1038},"cordis-european-research-council-award-101201543","Cracking the code on tumor targeting with nanostructures: competitive kinetics and extracellular vesicles","UNIVERSIDAD DE ZARAGOZA","€3,121,375","Today cancer remains a huge health concern, with around 20 million new cases and 10 million deaths per year worldwide. However, according to expectations, Nanomedicine should have ended cancer long time ago. The first nanomedicine (DoxilTM) a liposomal formulation based on the Enhanced Permeation and Retention (EPR) effect, dates from 1995. In the ensuing three decades, hundreds of anticancer nanoparticles with exciting properties were developed, but only a handful have reached the clinic, with ",{"id":1040,"funder":7,"programme":8,"title":1041,"piName":14,"institution":1042,"country":155,"year":13,"amount":1043,"abstract":1044},"cordis-european-research-council-award-101200693","From gas to dust: searching for the reactions at the origin of the first solids in the solar system","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€2,497,097","Astrophysical observations of young stellar objects and their disks, as well as studies of the components of primitive meteorites, concur to demonstrate that many of the mineralogical, chemical and isotopic characteristics of the first planetesimals to form in the protosolar nebula (PSN) were established during the first few hundreds of thousands of years of the solar system. However, the chemical and physical processes that transformed the dust and gas of the parent molecular cloud into the dus",{"id":1046,"funder":7,"programme":8,"title":1047,"piName":14,"institution":1048,"country":355,"year":13,"amount":1049,"abstract":1050},"cordis-european-research-council-award-101201360","Light interaction with synthetically moving metamaterials","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€3,021,615","Metamaterials rely on spatial structures on the scale of light wavelength to transform and enhance their macroscopic properties. Current metamaterials passively redistribute wave energy in space only, enabling, for example, sub-micron flat lenses and ultra-compact spectrometers. In the last few years, exciting breakthroughs have shown that metamaterials can also power wave-based analogue computation a technology for fast, massively parallel computation at a fraction of the power. With low energy",{"id":1052,"funder":7,"programme":8,"title":1053,"piName":14,"institution":1042,"country":155,"year":13,"amount":1054,"abstract":1055},"cordis-european-research-council-award-101201007","Diversification of the Eukaryotic Plankton  in the Sunlit Ocean","€2,495,782","Oceanic plankton constitute a diverse array of organisms crucial to Earth’s carbon cycle, climate regulation, and the functioning of the ecosystems. A key biological challenge lies in understanding the build-up of planktonic diversity in the global oceans. Two primary limitations are the scarcity of robust (phylo)genetic data for most plankton groups, and the lack of computational tools designed to explore diversification in the ocean, continually shaped by currents. Here, I propose to character",{"id":1057,"funder":7,"programme":8,"title":1058,"piName":14,"institution":1042,"country":155,"year":13,"amount":1059,"abstract":1060},"cordis-european-research-council-award-101201077","Quantum entanglement with ultrashort charge wavepackets","€2,488,810","A significant challenge in quantum nanoelectronics is accessing the internal characteristic timescales, typically a few picoseconds, that dictate the quantum dynamics of nanoelectronic quantum devices. These timescales are currently beyond our reach. If achieved, this will open new path for studying the dynamic aspects of quantum mechanics. ULTRAWAVE will overcome this challenge by leveraging advances in THz photon production and utilizing innovative photon-to-electron conversion devices to engi",{"id":1062,"funder":7,"programme":8,"title":1063,"piName":14,"institution":1042,"country":155,"year":13,"amount":1064,"abstract":1065},"cordis-european-research-council-award-101201156","Free Electrons to Bound Electrons and Photons Quantum Coherent Coupling","€3,495,436","Quantum coherence, a cornerstone of modern physics, encompasses phenomena like quantum entanglement and Rabi oscillations, which lack classical analogs. FreeQCC seeks to expand the frontiers of quantum mechanics by leveraging advances in free electron beam nanophysics and quantum nano-optics. Key questions include whether a free electron can be entangled with an atom or photon, and if a solid qubit's quantum coherence can be imprinted onto a free electron beam. By exploiting the quantum properti",{"id":1067,"funder":7,"programme":8,"title":1068,"piName":14,"institution":1069,"country":355,"year":13,"amount":1070,"abstract":1071},"cordis-european-research-council-award-101198911","Trading Truths: Missionaries, Diplomats, and Spies in the South Caucasus","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","€2,499,037","TRASUS investigates how religious and political truths move across boundaries. The objectives are to identify the modalities of how truths travel, to propel incisive understandings of how truth-values are attached to collective ideas, and how the resulting truths configure and reconfigure social worlds. Such an in-depth study that theorizes the workings of truth is of paramount importance in an age of misinformation and fake news, in which the transmission of truth is a crucial weapon of power.T",{"id":1073,"funder":7,"programme":8,"title":1074,"piName":14,"institution":514,"country":355,"year":13,"amount":1075,"abstract":1076},"cordis-european-research-council-award-101199408","Early Identification of Dyslexia and DLD using Speech Production Measures with Children:  An Innovative Cross-Language Approach","€2,498,644","Language problems are common in children, with ~7% incidence of significant spoken language problems (Developmental Language Disorder, DLD) and a further ~7% for written language problems (Developmental Dyslexia, DD). While there can be overlap in behavioural indices of DLD and DD (eg prosodic difficulties), no accepted causal theories satisfactorily explain such overlaps, and early identification remains difficult: only half of “late talkers”, toddlers who are not speaking by age 2, go on to de",{"id":1078,"funder":7,"programme":8,"title":1079,"piName":14,"institution":1042,"country":155,"year":13,"amount":1080,"abstract":1081},"cordis-european-research-council-award-101200010","Geometric constraints and feedback during tissue morphogenesis","€2,921,360","During development, cell movements and shape changes give rise to complex 3D forms. What underlies the fidelity of morphogenesis? To date, much emphasis has been placed on understanding how genes and local mechanics drive cell shape changes and tissue scale morphogenesis. However, the roles of the geometric properties of a tissue and its physical boundaries, their size, dimensionality, curvature and overall shape have recently emerged as important yet overlooked features of morphogenesis. This i",{"id":1083,"funder":7,"programme":8,"title":1084,"piName":14,"institution":1085,"country":155,"year":13,"amount":1086,"abstract":1087},"cordis-european-research-council-award-101201503","The Imperial Encounter in Early Islamic Egypt:  Dissecting the Aphrodito Archive","UNIVERSITE D'AIX MARSEILLE","€2,192,235","Named ‘Aphrodito archive’ because it originates in that otherwise unremarkable Middle-Egyptian town, the most important papyrological archive of the early Caliphate contains the papers of an early-eighth-century district administrator, including correspondence with the provincial governor in the new Muslim capital Fustat, and with village heads in his district, as well as registers and accounts generally related to tax and resource extraction.Known for over a century, the Aphrodito archive remai",{"id":1089,"funder":7,"programme":8,"title":1090,"piName":14,"institution":1042,"country":155,"year":13,"amount":1091,"abstract":1092},"cordis-european-research-council-award-101199244","TEStis or OVAry: Identifying the molecular and cellular processes controlling sex determination.","€2,495,021","Sex determination is the process that allows the bipotential gonad to develop into a testis or an ovary, thus initiating the sex fate of the individual. In mammals, the supporting cells are the first to adopt a sexual identity and then direct the differentiation of the other gonadal cell types. Despite their key role, we still do not know how these important cells acquire their identity. To address this question, we will use spatial transcriptomics and lineage tracing analysis in combination wit",{"id":1094,"funder":7,"programme":8,"title":1095,"piName":14,"institution":1096,"country":396,"year":13,"amount":1097,"abstract":1098},"cordis-european-research-council-award-101200948","Criminal Life-Course Trajectories Globally","UNIVERSITETET I OSLO","€2,492,420","How do social contexts determine paths into crime? How do these trajectories vary across different societal circumstances? And how are they narrated? CRIMEGLO is the first-ever large-scale comparative life-course criminological study globally. No research hitherto has addressed criminal careers and storytelling in such detail and on the scale envisaged in this project. The approach will counterweight the current Northern bias in research and theory, a shift necessary to establish a truly global ",{"id":1100,"funder":7,"programme":8,"title":1101,"piName":14,"institution":1096,"country":396,"year":13,"amount":520,"abstract":1102},"cordis-european-research-council-award-101199790","The Mathematization of Nature: The Origin of Mathematical Physics in Plato and Early Pythagoreanism","‘The Book of Nature is written in geometrical characters’, wrote Galileo in 1623. The view that mathematics provides the language of nature has been an axiom of physics since Copernicus, Galileo and Kepler. Behind the founders of modern science stood, by their own admission, ‘our genuine masters, Plato and Pythagoras’ (Kepler 1597). But how did the early Pythagoreans and Plato conceive of and justify their mathematical world view? MatNat investigates the question of the historical origin of the ",{"id":1104,"funder":7,"programme":8,"title":1105,"piName":14,"institution":1106,"country":155,"year":13,"amount":374,"abstract":1107},"cordis-european-research-council-award-101201163","REvolutionising the use of coherent x-ray diffraction for structural crystallography Applied to CaTalysis","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","Heterogeneous (electro-, photo-) catalysis is at the heart of our modern chemical industry, driving 90% of chemical manufacturing processes. Key challenges include measuring reaction kinetics, identifying intermediates and bridging the “pressure” and “materials” gaps. To study the behaviour of individual nanocatalysts involved in chemical reactions, I will develop new, faster structural and chemical characterisation systems and state-of-the-art in situ monitoring techniques to address catalytic ",{"id":1109,"funder":7,"programme":8,"title":1110,"piName":14,"institution":1096,"country":396,"year":13,"amount":1111,"abstract":1112},"cordis-european-research-council-award-101201478","The Waging of War","€2,399,126","Wars are raging around the world. War has terrible consequences: soldiers and civilians are killed or wounded, millions are forced to flee their homes, buildings and infrastructure are destroyed, and children, especially, are put at risk of sickness and death; the suffering is astounding. Some of this is unintended, but too much of the suffering is intentional. Wars are fought in myriad ways, ranging from conventional interstate war to intrastate guerilla insurgencies to terrorist actions. The w",{"id":1114,"funder":7,"programme":8,"title":1115,"piName":14,"institution":1116,"country":57,"year":13,"amount":374,"abstract":1117},"cordis-european-research-council-award-101200433","Meta-Learned Machine-Learning Interatomic Potentials for Ab initio Engineering of Chemical and Microstructural Complexity","UNIVERSITY OF STUTTGART","Materials engineers have dreamed for decades of optimizing materials starting from the quantum mechanical laws of nature. Mastering the inherent chemical and microstructural complexity promises access to outstanding properties of structural and functional materials. Machine-learning interatomic potentials (MLIPs) ignited hope by offering quantum-mechanical accuracy for systems with many atoms. However, the full capacity of MLIPs remains untapped due to the complexity of the MLIP construction pro",{"id":1119,"funder":7,"programme":8,"title":1120,"piName":14,"institution":503,"country":110,"year":13,"amount":1121,"abstract":1122},"cordis-european-research-council-award-101200657","Casimir Self-Assembly out of Equilibrium","€2,469,830","Self-assembly is an important area of research that has numerous practical applications, including in the fields of materials science, nanotechnology, and biotechnology. Despite its widespread use, conventional self-assembly is limited, especially in terms of complexity, scalability, and dynamical control. In this context, a promising solution to these challenges is the use of Casimir self-assembly, which leverages the fundamental physics of the Casimir effect. The Casimir effect refers to the f",{"id":1124,"funder":7,"programme":8,"title":1125,"piName":14,"institution":1126,"country":12,"year":13,"amount":374,"abstract":1127},"cordis-european-research-council-award-101199326","Modelling the impact of aging in sporadic Alzheimer’s disease","VIB VZW","Understanding therapeutic opportunities in Alzheimer’s disease (AD), the most common form of progressive neurodegeneration, is limited due to lack of animal models that replicate the disease’s consecutive stages. We achieved a breakthrough by xenografting human stem cell-derived neurons into mouse brains, where they integrate and survive up to two years, developing typical AD hallmarks. Neighbouring mouse neurons remain resilient to AD, underscoring unique human neuronal features not mirrored in",200,{"programme":8,"total":1130,"withPiName":1131,"firstYear":1132,"lastYear":1133,"countryCount":1134,"perYear":1135,"topInstitutions":1192,"topCountries":1260},4756,450,2008,2027,46,[1136,1138,1141,1144,1147,1150,1153,1156,1159,1162,1164,1167,1170,1173,1176,1179,1182,1185,1188,1190],{"year":1132,"count":1137},47,{"year":1139,"count":1140},2009,232,{"year":1142,"count":1143},2010,248,{"year":1145,"count":1146},2011,276,{"year":1148,"count":1149},2012,293,{"year":1151,"count":1152},2013,344,{"year":1154,"count":1155},2014,359,{"year":1157,"count":1158},2015,138,{"year":1160,"count":1161},2016,299,{"year":1163,"count":1140},2017,{"year":1165,"count":1166},2018,376,{"year":1168,"count":1169},2019,241,{"year":1171,"count":1172},2020,137,{"year":1174,"count":1175},2021,228,{"year":1177,"count":1178},2022,322,{"year":1180,"count":1181},2023,252,{"year":1183,"count":1184},2024,243,{"year":1186,"count":1187},2025,222,{"year":13,"count":1189},264,{"year":1133,"count":1191},3,[1193,1196,1199,1202,1204,1207,1209,1212,1215,1218,1221,1224,1226,1229,1232,1235,1238,1241,1243,1246,1248,1250,1252,1255,1257],{"name":1194,"count":1195},"Centre National de la Recherche Scientifique CNRS",206,{"name":1197,"count":1198},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",133,{"name":1200,"count":1201},"University of Oxford",128,{"name":70,"count":1203},124,{"name":1205,"count":1206},"Eidgenoessische Technische Hochschule Zuerich",84,{"name":43,"count":1208},74,{"name":1210,"count":1211},"École Polytechnique Fédérale de Lausanne",72,{"name":1213,"count":1214},"University College London",69,{"name":1216,"count":1217},"Ludwig-Maximilians-Universitaet Muenchen",59,{"name":1219,"count":1220},"The Hebrew University of Jerusalem",57,{"name":1222,"count":1223},"Katholieke Universiteit Leuven",52,{"name":240,"count":1225},49,{"name":1227,"count":1228},"University of Edinburgh",48,{"name":1230,"count":1231},"Kobenhavns Universitet",40,{"name":1233,"count":1234},"Universiteit van Amsterdam",39,{"name":1236,"count":1237},"Institut National de la Sante Et de la Recherche Medicale",38,{"name":1239,"count":1240},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",35,{"name":1242,"count":1240},"Tel Aviv University",{"name":1244,"count":1245},"Imperial College of Science Technology and Medicine",33,{"name":1247,"count":1245},"Technische Universitaet Muenchen",{"name":1249,"count":1245},"Universitat Wien",{"name":1251,"count":1245},"University of Manchester",{"name":1253,"count":1254},"Helsingin Yliopisto",32,{"name":1256,"count":1254},"Karolinska Institutet",{"name":1258,"count":1259},"Technische Universiteit Delft",30,[1261,1263,1265,1267,1269,1271,1273,1275,1277,1279,1281,1282,1284,1286,1289,1291,1293,1294,1297,1299,1301,1303,1306,1308,1310],{"name":57,"count":1262},802,{"name":355,"count":1264},778,{"name":155,"count":1266},581,{"name":169,"count":1268},390,{"name":130,"count":1270},310,{"name":148,"count":1272},302,{"name":97,"count":1274},269,{"name":44,"count":1276},202,{"name":110,"count":1278},183,{"name":117,"count":1280},153,{"name":12,"count":1280},{"name":50,"count":1283},107,{"name":71,"count":1285},78,{"name":1287,"count":1288},"FI",76,{"name":396,"count":1290},65,{"name":731,"count":1292},42,{"name":25,"count":1231},{"name":1295,"count":1296},"HU",25,{"name":464,"count":1298},24,{"name":32,"count":1300},20,{"name":571,"count":1302},18,{"name":1304,"count":1305},"CZ",15,{"name":1307,"count":1305},"SI",{"name":78,"count":1309},9,{"name":321,"count":1311},8]