[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-consolidator-grant-2014":3,"awarded-stats-erc-consolidator-grant":1119},{"awarded":4,"total":1118},[5,16,23,29,35,42,49,56,62,69,75,80,87,93,99,104,109,114,121,127,134,139,145,150,157,163,169,174,180,185,190,196,203,209,214,220,225,231,238,243,248,253,259,266,272,277,282,287,292,299,305,311,317,322,328,334,339,345,351,357,363,368,374,379,385,391,397,403,408,413,419,425,431,437,443,449,455,461,465,469,474,480,486,490,496,502,507,513,518,524,530,534,539,543,549,555,561,567,573,579,586,591,597,602,607,613,618,624,630,635,640,646,651,657,663,668,673,679,684,690,695,700,706,711,716,721,727,732,737,742,748,754,760,767,772,777,783,789,795,801,806,812,818,823,828,833,838,842,848,854,860,866,871,875,880,885,890,895,899,905,911,917,923,928,933,937,942,947,952,957,962,968,974,979,983,988,993,998,1004,1009,1014,1020,1026,1030,1035,1040,1045,1051,1056,1062,1068,1073,1078,1083,1087,1093,1098,1104,1108,1113],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-european-research-council-award-cog-615653","European Research Council","ERC Consolidator Grant","Ligand Exchange and Redox Processes in Iridium Triazolylidene Complexes Relevant to Catalytic Water Oxidation","Ana Petronilho","University College Dublin","IE",2014,null,"Iridium(III) complexes containing a bidentate spectator ligand have emerged as powerful catalyst precursors for water oxidation. Here we investigate the initial steps of the transformation at the iridium center when using complex [IrCp*(pyr-trz)Cl] 1 (Cp* = pentamethylcyclopentadienyl, pyr-trz = 4-(2-pyridyl)-1,2,3-triazol-5-ylidene), a potent water oxidation catalyst precursor. Ligand exchange with water is facile and is reversed in the presence of chloride ions, while MeCN substitution is effe",{"id":17,"funder":7,"programme":8,"title":18,"piName":14,"institution":19,"country":20,"year":13,"amount":21,"abstract":22},"cordis-european-research-council-award-617521","Nonlinear Laser Lithography","BILKENT UNIVERSITESI VAKIF","TR","€1,999,920","Control of matter via light has always fascinated humankind",{"id":24,"funder":7,"programme":8,"title":25,"piName":14,"institution":26,"country":27,"year":13,"amount":14,"abstract":28},"cordis-european-research-council-award-617659","The Great War and Modern Philosophy","KATHOLIEKE UNIVERSITEIT LEUVEN","BE","The First World War was an unprecedented event of destruction, transformation, and renewal that left no aspect of European culture unchanged. Philosophy proved no exception: the war motivated an historically singular mobilization of philosophers to write about the war during the years of conflict",{"id":30,"funder":7,"programme":8,"title":31,"piName":14,"institution":32,"country":14,"year":13,"amount":33,"abstract":34},"cordis-european-research-council-award-615785","Emerging Subjects of the New Economy: Tracing Economic Growth in Mongolia","UNIVERSITY COLLEGE LONDON","€1,658,373","This project examines how predicted economic growth is experienced by people in Mongolia with the advent of large-scale mining operations. Our project will generate new insight into two areas of concern for economic anthropology and beyond.  First we will examine the way that the economy is unfolding in a distinct way in East Asia through different kinds of predictive narratives that come to have an effect on the way people act. Second we will explore how individual subjects also shape the econo",{"id":36,"funder":7,"programme":8,"title":37,"piName":14,"institution":38,"country":39,"year":13,"amount":40,"abstract":41},"cordis-european-research-council-award-614879","New Directions for Monetary Policy Analysis","LUISS LIBERA UNIVERSITA INTERNAZIONALE DEGLI STUDI SOCIALI GUIDO CARLI","IT","€837,680","The research under this proposal aims at a better understanding of monetary policy in light of the recent events following the financial crisis. There are three main objectives. The first is to study monetary policy in models where financial securities have different liquidity properties which could vary over time and be subject to sudden changes. The new framework will address the mechanisms at the root of the financial crisis and its propagation to real economic activity and at the same time s",{"id":43,"funder":7,"programme":8,"title":44,"piName":14,"institution":45,"country":46,"year":13,"amount":47,"abstract":48},"cordis-european-research-council-award-617233","Cell Migration under Mechanical Constraints","Université Paris Diderot-Paris 7","FR","€1,762,734","Control of cell migration is crucial for many biological processes. Cells sense mechanical cues to guide their migration. As opposed to passive materials, living cells actively respond to the mechanical stimuli of their environment through the transduction of mechanical information into biochemical signaling events. These responses, particularly to rigidity, include differentiation, migration and alterations in cell-matrix and cell-cell adhesion and thus occur over a wide range of time and lengt",{"id":50,"funder":7,"programme":8,"title":51,"piName":14,"institution":52,"country":53,"year":13,"amount":54,"abstract":55},"cordis-european-research-council-award-617142","Neural bases of action chunking in basal ganglia subcircuits","FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD","PT","€1,998,600","Chunking allows the brain to efficiently organize memories and actions. Although basal ganglia circuits have been implicated in action chunking, little is known about how individual elements are concatenated into a behavioral unit at the neuronal level. Using a differential reinforcement procedure where mice learn to chunk rapid action sequences, we uncovered neuronal activity encoding entire sequences as single actions in basal ganglia circuits. Besides activity signaling sequence initiation (s",{"id":57,"funder":7,"programme":8,"title":58,"piName":14,"institution":59,"country":60,"year":13,"amount":14,"abstract":61},"cordis-european-research-council-award-615588","Peopling Europe: How data make a people","GOLDSMITHS' COLLEGE","UK","Who are the people of Europe? This question is facing statisticians as they grapple with standardising national census methods so that their numbers can be assembled into a European population. Yet, by so doing—intentionally or otherwise—they also contribute to the making of a European people. This, at least, is the central thesis of ARITHMUS. While typically framed as a methodological or statistical problem, the project approaches this as a practical and political problem of assembling multiple",{"id":63,"funder":7,"programme":8,"title":64,"piName":14,"institution":65,"country":66,"year":13,"amount":67,"abstract":68},"cordis-european-research-council-award-617185","Determination of top couplings in associated top pair events using ATLAS data","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","DE","€1,964,088","The discovery of a new particle, compatible with the Higgs boson, at the Large Hadron Collider, marked a major triumph of the Standard Model of particle physics. However, many fundamental questions remain and direct or indirect evidence of new physics can be probed with the large number of proton-proton collision data, collected in 2011 and 2012 at 7 and 8 TeV centre-of-mass energy.With this proposal we plan to exploit the large sample of top-quark pair events that is already recorded, and the s",{"id":70,"funder":7,"programme":8,"title":71,"piName":14,"institution":72,"country":60,"year":13,"amount":73,"abstract":74},"cordis-european-research-council-award-614030","Using Galaxy Surveys to Understand the Dark Universe","UNIVERSITY OF PORTSMOUTH HIGHER EDUCATION CORPORATION","€2,151,192","Galaxy Surveys are a key resource for observational cosmology, with the potential to provide the answers to many fundamental questions in modern physics. The Darksurvey project will use the Dark Energy Survey (DES) and extended-Baryon Oscillation Spectroscopic Survey (eBOSS) within which Will Percival has key leadership positions, and future projects including MS-DESI to measure the cosmological expansion rate between redshifts 0.5 and 2, testing Dark Energy. Complimentary structure growth measu",{"id":76,"funder":7,"programme":8,"title":77,"piName":14,"institution":78,"country":66,"year":13,"amount":14,"abstract":79},"cordis-european-research-council-award-616024","Structural basis of mitochondrial inner membrane shape and dynamic","MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)","Here, I propose to study the structure and mechanisms of the cellular machineries mediating the shape and dynamics of the mitochondrial inner membrane (IM). The mitochondrial IM contains membrane invaginations called cristae. These are connected by tubular openings, the crista junctions, to the remaining IM. Mitochondrial shape constantly changes due to membrane fission and fusion events, and a balance of both processes is required for proper functioning of mitochondria. Abnormal mitochondrial s",{"id":81,"funder":7,"programme":8,"title":82,"piName":14,"institution":83,"country":84,"year":13,"amount":85,"abstract":86},"cordis-european-research-council-award-615651","The Macroeconomics of Collateral","Centre de Recerca en Economia Internacional (CREI)","ES","€979,800","Financial markets constitute the backbone of modern economies, intermediating resources from those who have them (i.e., lenders) to those who can put them to productive use (i.e., borrowers). The defining feature of these markets is that they entail the exchange of goods today for a borrower’s promise to deliver goods in the future. These promises are sustained by guarantees, which are akin to the amount of future income that borrowers can credibly pledge to lenders. I refer to this pledgeable i",{"id":88,"funder":7,"programme":8,"title":89,"piName":14,"institution":90,"country":39,"year":13,"amount":91,"abstract":92},"cordis-european-research-council-award-616803","Invariant visual object representations in the early postnatal and adult cortex: bridging theory, model and neurobiology","SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE","€2,000,000","Our visual system can effortlessly recognize hundreds of thousands of objects in spite of tremendous variation in their appearance, resulting, for instance, from changes in object position and pose. Achieving such an invariant representation of the visual world is an extremely challenging computational problem that even the most advanced artificial vision systems are not fully able to solve. This is why understanding the neuronal mechanisms underlying object vision is one of the major challenges",{"id":94,"funder":7,"programme":8,"title":95,"piName":14,"institution":96,"country":60,"year":13,"amount":97,"abstract":98},"cordis-european-research-council-award-616170","Precision Cosmological Parameters","THE UNIVERSITY OF SUSSEX","€1,372,496","Proposal summary (half page, possibly copy\u002Fpaste abstract from the administrative form A1)Observations of the Cosmic Microwave Background (CMB) allow us to see 98% of the way to the big bang, back to a time when the Universe was only a few hundred thousand years old. Other forthcoming data will probe the more local universe in great detail. To test different possible universe models we need accurate theoretical predictions for this data in each model, and new sampling methods to solve the infere",{"id":100,"funder":7,"programme":8,"title":101,"piName":14,"institution":96,"country":60,"year":13,"amount":102,"abstract":103},"cordis-european-research-council-award-617678","Lifespan Development of Typical and Atypical Multisensory Perception","€1,314,131","Daily life confronts us with information across multiple senses in parallel and we must somehow unite these sensations into a coherent interpretation of the world. MULTISENSE will explain how the human brain comes to develop this complex ability, and how certain genetically ‘pre-marked’ brains can come to experience multisensory integration in remarkable ways. Implicit associations across the senses can have a profound and sometimes surprising effect on our experiences (eg, the  taste of food ca",{"id":105,"funder":7,"programme":8,"title":106,"piName":14,"institution":107,"country":46,"year":13,"amount":14,"abstract":108},"cordis-european-research-council-award-616180","Dark matter of the human transcriptome: Functional study of the antisense Long Noncoding RNAs and Molecular Mechanisms of Action","INSTITUT CURIE","98% of the human genome is non-protein coding raising the question of the role of the dark matter of the genome. It is now admitted that pervasive transcription generates thousands of noncoding transcripts that regulate gene expression and have broad impacts on development and disease. Among the long non coding (lnc)RNAs, antisense transcripts have been poorly studied despite their putative regulatory importance. Several functional examples include X-chromosome inactivation, maintenance of pluri",{"id":110,"funder":7,"programme":8,"title":111,"piName":14,"institution":65,"country":66,"year":13,"amount":112,"abstract":113},"cordis-european-research-council-award-616082","Unconventional pairing in ultracold Fermi gases","€1,925,525","We explore unconventional ways how ultracold fermions pair and form collective quantum phases exhibiting long-range order, such as superfluidity and magnetically order. Specifically, we plan to realize and study pairing with orbital angular momentum and pairing induced by long-range interaction. Besides the fundamental interest in unravelling unconventional pairing mechanisms and the interplay between superfluidity and quantum magnetism, our project will also lead to gaining experimental control",{"id":115,"funder":7,"programme":8,"title":116,"piName":14,"institution":117,"country":118,"year":13,"amount":119,"abstract":120},"cordis-european-research-council-award-616072","Joint action expertise: Behavioral, cognitive, and neural mechanisms for joint action learning","KOZEP-EUROPAI EGYETEM","HU","€1,992,331","Human life is full of joint action and our achievements are, to a large extent, joint achievements that require the coordination of two or more individuals. Piano duets and tangos, but also complex technical and medical operations rely on and exist because of coordinated actions. In recent years, research has begun to identify the basic mechanisms of joint action. This work focused on simple tasks that can be performed together without practice. However, a striking aspect of human joint action i",{"id":122,"funder":7,"programme":8,"title":123,"piName":14,"institution":124,"country":53,"year":13,"amount":125,"abstract":126},"cordis-european-research-council-award-615594","Gender citizenship and sexual rights in Europe: transgender lives from a transnational perspective","INSTITUTO DE CIENCIAS SOCIAIS","€1,262,943","The TRANSRIGHTS project investigates transgender lives and the institutional apparatus that frames them. Rather than focusing exclusively on self displayed identities, four lines of inquiry will be developed. Firstly, gender politics and sexual rights are analyzed as the opposition between politics of equality and of difference is unable to provide answers for the inclusion of trans-people. Secondly, by comparing the lives of trans-people in five European countries – Portugal, France, United Kin",{"id":128,"funder":7,"programme":8,"title":129,"piName":14,"institution":130,"country":131,"year":13,"amount":132,"abstract":133},"cordis-european-research-council-award-617102","DNA Replication Stress in Cancer","University of Zurich","CH","€1,846,500","DNA replication is a crucial, but potentially dangerous process in every cellular division. A failure to maintain the integrity of replicating chromosomes leads to genome instability, an early event in tumorigenesis. Most common anti-cancer drugs also interfere with DNA synthesis, by largely undefined mechanisms. My lab specializes in the structural and molecular characterization of DNA replication stress in higher eukaryotes, combining standard cell and molecular biology with specialized single",{"id":135,"funder":7,"programme":8,"title":136,"piName":14,"institution":107,"country":46,"year":13,"amount":137,"abstract":138},"cordis-european-research-council-award-616140","Epigenetic Control of Mammalian Reproduction","€1,999,416","By standing at the crossroads of generations, germ cells ensure species continuity. At the time of fertilization, the oocyte and spermatozoon carry the genetic material but also non-genetically encoded, epigenetic information. Gametic epigenetic modifications have immediate effects on gametic production and fertility. They also have long-term consequences on somatic phenotypes when transmitted to the progeny. Our team has previously made some important contributions to the emergence of these con",{"id":140,"funder":7,"programme":8,"title":141,"piName":14,"institution":142,"country":53,"year":13,"amount":143,"abstract":144},"cordis-european-research-council-award-615638","Mechanisms of Chromatin-based Epigenetic Inheritance","FUNDACAO CALOUSTE GULBENKIAN","€1,621,400","Epigenetic mechanisms heritably maintain gene expression states and chromosome organization across cell division. These include chromatin-based factors that are propagated independent of local DNA sequence elements, and are critical for normal development and prevent reprogramming, e.g. during induction of pluripotency. We focus on the role of nucleosomes, the histone-DNA complexes that make up chromatin. While prominently implicated in epigenetic memory, how histones and their local modificatio",{"id":146,"funder":7,"programme":8,"title":147,"piName":14,"institution":32,"country":14,"year":13,"amount":148,"abstract":149},"cordis-european-research-council-award-617837","Specificity of translational control during unfolded protein response","€1,999,435","Unfolded protein response (UPR) is activated by multiple types of cellular stress, and can promote either cell survival or apoptosis. The balance between these opposing outcomes is delicately regulated, and when lost, contributes to diverse diseases. UPR enables cells to halt general translation, while inducing translation and transcription of specific mRNAs that escape repression. Even though the general machinery controlling translation is well understood, several fundamental open questions re",{"id":151,"funder":7,"programme":8,"title":152,"piName":14,"institution":153,"country":154,"year":13,"amount":155,"abstract":156},"cordis-european-research-council-award-617376","The making and breaking of ubiquitin chains in cholesterol metabolism","ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM","NL","€1,999,998","Elevated levels of circulating LDL-cholesterol are a major determinant contributing to atherogenesis and coronary artery disease. Therefore, many studies address the central transcriptional pathways that regulate cholesterol metabolism. However, transcriptional regulation does not allow cells to quickly adapt to the cholesterol fluxes that they encounter. For this, rapid and reversible post-transcriptional modifications are used, in conjunction with transcriptional control. Ubiquitylation - the ",{"id":158,"funder":7,"programme":8,"title":159,"piName":14,"institution":160,"country":66,"year":13,"amount":161,"abstract":162},"cordis-european-research-council-award-617198","C9orf72 repeat expansion in FTD\u002FALS - from mechanisms to therapeutic approaches","DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV","€1,991,000","Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal neurodegenerative diseases with overlapping genetics and pathology. The most common known cause is expansion of a GGGGCC repeat in the first intron of the gene C9orf72. I discovered that the repeat region is translated in all three reading frames into aggregating dipeptide-repeat (DPR) proteins despite its intronic localization and lack of an ATG start codon. DPR aggregates outnumber the previously identified TDP-43 ",{"id":164,"funder":7,"programme":8,"title":165,"piName":14,"institution":166,"country":66,"year":13,"amount":167,"abstract":168},"cordis-european-research-council-award-617129","Geometry, Groups and Model Theory","Westfälische Wilhelms-Universität Münster","€1,284,000","Our proposed research lies at the interface of Geometry, Group Theory, Number Theory and Combinatorics. In recent years, striking results were obtained in those disciplines with the help of a surprise newcomer at the border between mathematics and logic: Model Theory. Bringing its unique point of view and its powerful formalism, Model Theory made a resounding entry into several different fields of mathematics. Here shedding new light on a classical phenomenon, there solving a long-standing open ",{"id":170,"funder":7,"programme":8,"title":171,"piName":14,"institution":65,"country":66,"year":13,"amount":172,"abstract":173},"cordis-european-research-council-award-615381","Optogenetic control of cellular behaviour by allosteric ribonucleic acid assemblies","€1,992,438","Light-sensitive channel proteins have attracted much attention as functional molecules, as they possess unique conformations and functions depending on their respective irradiation states. Embedding these proteins in heterogeneous cellular frameworks enabled to gain light-control of cellular and in particular neuronal behaviour. However to date, optogenetic solutions that address endogenous, intracellular biomolecules in a universal fashion remain elusive. The project will apply design and selec",{"id":175,"funder":7,"programme":8,"title":176,"piName":14,"institution":177,"country":53,"year":13,"amount":178,"abstract":179},"cordis-european-research-council-award-617676","Positioning the nucleus for cell migration and muscle fiber function","INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES","€1,968,000","The cell nucleus is positioned at specific places within the cytoplasm and this position is important for different cellular, developmental and physiological processes. Nuclear positioning depends on connections between nuclear envelope proteins and the cytoskeleton. In migrating cells, we found that the nucleus is positioned away from the front of the cell and this event is important for cell migration. We performed an RNAi screen for nuclear positioning and found new nuclear envelope proteins ",{"id":181,"funder":7,"programme":8,"title":182,"piName":14,"institution":166,"country":66,"year":13,"amount":183,"abstract":184},"cordis-european-research-council-award-616564","New isotope tracers for core formation in terrestrial planets","€1,940,040","This proposal aims to develop new isotopic tools designed to constrain the core formation process in the Earth. We will use isotopic fractionations imparted by metal-silicate equilibration during core formation to obtain new and firm constraints on (i) the physical and chemical processes during formation of the Earth's core; and (ii) on the origin of volatile elements and the volatile accretion history of the Earth. The underlying concept of our  approach is to compare observed mantle-core isoto",{"id":186,"funder":7,"programme":8,"title":187,"piName":14,"institution":130,"country":131,"year":13,"amount":188,"abstract":189},"cordis-european-research-council-award-614791","Performance-Art in Eastern Europe (1950-1990): History and Theory","€1,998,302","The aim of this project is to provide, for the very first time, an overview of the historical and transnational development of performance art (performances, actions, happenings) in Eastern Europe during the dictatorship period. Performance art shall not only be presented as an object of study, but also as a central art genre implicitly and explicitly involved both in the investigation of cultural practices and in the creation of alternative ways of action. The project focuses, for one, on the a",{"id":191,"funder":7,"programme":8,"title":192,"piName":14,"institution":193,"country":118,"year":13,"amount":194,"abstract":195},"cordis-european-research-council-award-617747","Limits of discrete structures","HUN-REN RENYI ALFRED MATEMATIKAI KUTATOINTEZET","€1,175,200","Built on decades of deep research in ergodic theory, Szemeredi's regularity theory and statistical physics, a new subject is emerging whose goal is to study convergence and limits of various structures.The main idea is to regard very large structures in combinatorics and algebra as approximations of infinite analytic objects. This viewpoint brings new tools from analysis and topology into these subjects. The success of this branch of mathematics has already been demonstrated through numerous app",{"id":197,"funder":7,"programme":8,"title":198,"piName":14,"institution":199,"country":200,"year":13,"amount":201,"abstract":202},"cordis-european-research-council-award-615068","The Leukemia-Initiating Cell: Genetic Determinants, Escape Mechanisms and Ontogenic Influence","MAX IV Laboratory, Lund University","SE","€1,999,714","Acute myeloid leukemia (AML) is the most common malignant myeloid disorder in adults and strongly associated in incidence to advanced age. AML arises from immature hematopoietic progenitor cells via a sequential multistep process, but the nature of these steps remains to a large extent unknown. Therefore, while significant efforts have previously been invested in characterizing the molecular properties of late-stage AML, as diagnosed in patients, less information is available on the events that ",{"id":204,"funder":7,"programme":8,"title":205,"piName":14,"institution":206,"country":84,"year":13,"amount":207,"abstract":208},"cordis-european-research-council-award-614578","Regulation of inflammatory response by extracellular ATP and P2X7 receptor signalling: through and beyond the inflammasome","FUNDACION PARA LA FORMACION E INVESTIGACION SANITARIAS DE LA REGION DE MURCIA","€1,794,948","Inflammatory diseases affect over 80 million people worldwide and accompany many diseases of industrialized countries, being the majority of them infection-free conditions. There are few efficient anti-inflammatory drugs to treat chronic inflammation and thus, there is an urgent need to validate novel targets. We now know that innate immunity is the main coordinator and driver of inflammation. Recently, we and others have shown that the activation of purinergic P2X7 receptors (P2X7R) in immune c",{"id":210,"funder":7,"programme":8,"title":211,"piName":14,"institution":45,"country":46,"year":13,"amount":212,"abstract":213},"cordis-european-research-council-award-616233","Theory of strongly correlated photonic systems","€1,378,440","The physics of complex quantum systems with controllable interactions is emerging as a fundamental topic for a broad community, providing an opportunity to test theories of strongly correlated quantum many-body systems and opening interesting applications such as quantum simulators. Recently, in solid-state structures with effective photon-photon interactions the rich physics of quantum fluids of light has been explored, albeit not yet in the regime of strong photonic correlations. Exciting adva",{"id":215,"funder":7,"programme":8,"title":216,"piName":14,"institution":217,"country":60,"year":13,"amount":218,"abstract":219},"cordis-european-research-council-award-617606","Systemic Risk and Feedback to the Real Economy","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","€698,938","In this proposal I present two research themes that apply endogenous risk analysis to identify channels for the creation of systemic risk via various feedback loops. These projects identify new ways to consider and measure systemic financial risks and, more importantly, the linkages between the financial risks and the real economy, and the welfare consequences.In the first research theme, the focus will be on the effect of network externality on systemic risk formation. I plan to model and estim",{"id":221,"funder":7,"programme":8,"title":222,"piName":14,"institution":223,"country":60,"year":13,"amount":14,"abstract":224},"cordis-european-research-council-award-617329","INTENSE: INTElligent use of climate models for adaptatioN to non-Stationary climate Extremes","UNIVERSITY OF NEWCASTLE UPON TYNE","The research proposed here will use a novel and fully-integrated data-modelling approach to provide a step-change in our understanding of the nature and drivers of global precipitation extremes and change on societally relevant timescales. Extreme precipitation is increasing globally and theoretical considerations suggest this will continue with global warming, but opportunistic datasets indicate that sub-daily precipitation extremes will intensify more than is anticipated. Determining the preci",{"id":226,"funder":7,"programme":8,"title":227,"piName":14,"institution":228,"country":84,"year":13,"amount":229,"abstract":230},"cordis-european-research-council-award-614944","A systems pharmacology approach to the discovery of novel therapeutics in Alzheimer´s disease","FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)","€1,296,000","Alzheimer´s disease (AD) is the most common form of dementia, with over 35 million people suffering from it worldwide, and it constitutes a personal and societal tragedy of immense proportions. Fifty years of intense research have revealed many key elements of the biology of this neurodegenerative disorder. However, our understanding of the molecular bases of the disease is still very limited, and the available medical treatments for AD are purely symptomatic and hardly effective. It is now clea",{"id":232,"funder":7,"programme":8,"title":233,"piName":14,"institution":234,"country":235,"year":13,"amount":236,"abstract":237},"cordis-european-research-council-award-614711","Regulation and function of linear ubiquitination by HOIP","INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH","AT","€1,997,908","Ubiquitin (Ub) is a small protein modifier, regulating diverse biological functions such as signalling, DNA repair and proteasomal degradation. Ub can form polymers via 7 Lys residues of Ub itself. Recently, we have discovered that an E3 ligase complex, Linear Ubiquitin chain Assembly Complex (LUBAC)  generates a novel type of Ub polymer linked via Met-1, ‘linear Ub chain’ and regulates NF-kB signalling in mice. Because linear Ub is unique and the study of it is still in infancy, the only E3 lig",{"id":239,"funder":7,"programme":8,"title":240,"piName":14,"institution":130,"country":131,"year":13,"amount":241,"abstract":242},"cordis-european-research-council-award-615988","Acquisition processes in maximally diverse languages: Min(d)ing the ambient language","€1,998,438","Children learn any language that they grow up with, adapting to any of the ca. 7000 languages of the world, no matter how divergent or complex their structures are. What cognitive processes make this extreme flexibility possible? This is one of the most burning questions in cognitive science and the ACQDIV project aims at answering it by testing and refining the following leading hypothesis: Language acquisition is flexible and adaptive to any kind of language because it relies on a small set of",{"id":244,"funder":7,"programme":8,"title":245,"piName":14,"institution":32,"country":14,"year":13,"amount":246,"abstract":247},"cordis-european-research-council-award-616121","Towards a molecular-level understanding of heterogeneous ice nucleation","€1,915,083","Ice formation is one of the most common phase transitions on Earth. It is relevant to an enormous variety of phenomena such as weathering, cloud formation, airline safety, agriculture, and energy. However, despite having been studied since antiquity, our molecular level understanding of ice formation is largely incomplete. In particular, almost all ice formation in nature is aided by impurities or the surfaces of foreign materials, yet how surfaces act to facilitate ice formation (heterogeneous ",{"id":249,"funder":7,"programme":8,"title":250,"piName":14,"institution":251,"country":60,"year":13,"amount":14,"abstract":252},"cordis-european-research-council-award-617844","Tumour Heterogeneity and Somatic Evolution of Unstable cancer genomes","THE FRANCIS CRICK INSTITUTE LIMITED","SummaryThe majority of metastastic solid tumours remain incurable. In-depth analysis of tumour genomes is revealing evidence for branched evolution and cancer subclonal spatial and temporal intratumour heterogeneity (ITH). Drivers of ITH such as chromosomal instability (CIN) are associated with drug resistance and poor clinical outcome. However, despite increasing knowledge of tumour diversity, there is limited insight into the mechanisms driving genomic instability and ITH or the processes that",{"id":254,"funder":7,"programme":8,"title":255,"piName":14,"institution":256,"country":257,"year":13,"amount":14,"abstract":258},"cordis-european-research-council-award-614331","Scalable Similarity Search","IT-UNIVERSITETET I KOBENHAVN","DK","Similarity search is the task of identifying, in a collection of items, the ones that are “similar” to a givenquery item. This task has a range of important applications (e.g. in information retrieval, patternrecognition, statistics, and machine learning) where data sets are often big, high dimensional, andpossibly noisy. State-of-the-art methods for similarity search offer only weak guarantees when faced withbig data. Either the space overhead is excessive (1000s of times larger than the space ",{"id":260,"funder":7,"programme":8,"title":261,"piName":14,"institution":262,"country":263,"year":13,"amount":264,"abstract":265},"cordis-european-research-council-award-615688","Programming with Millions of Examples","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","IL","€1,500,000","The goal of this proposal is to make programming easier and more productive. We propose to develop novel program synthesis techniques, generating procedural code from declarative specifications.Existing techniques apply synthesis at such a fine grain that they can never hope to generate code of the richness and complexity required by application-level programmers. In contrast, we aim to develop synthesis algorithms that leverage the collective programming knowledge captured in millions of open-s",{"id":267,"funder":7,"programme":8,"title":268,"piName":14,"institution":269,"country":60,"year":13,"amount":270,"abstract":271},"cordis-european-research-council-award-615443","Symmetry Principles in Nature","UNIVERSITY OF DURHAM","€1,400,758","Symmetries have traditionally played a very important role in our understanding of physics, both classical and quantum. As we move towards the next frontier of defining a quantum theory of gravity, it is clear that they will continue to play a predominant role. The current project is aimed at obtaining a comprehensive  understanding of the dynamics of strongly coupled quantum systems, exploiting various symmetry properties that one expects on physical grounds. Specifically, the aim is to come up",{"id":273,"funder":7,"programme":8,"title":274,"piName":14,"institution":269,"country":60,"year":13,"amount":275,"abstract":276},"cordis-european-research-council-award-617143","Neutrinos: a different portal to new physics Beyond the Standard Model","€1,702,663","In the past fifteen years, neutrino physics has revolutionised our understanding of particle physics. The discovery of neutrino oscillations implies that neutrinos have masses and mix: this is the only particle physics evidence of new physics beyond the Standard Model to date. Their origin remains a major challenge.The NuMass project will focus on new physics at low energy scales, below the one reachable at the LHC. This approach is opposite to widely studied Standard Model extensions, which inv",{"id":278,"funder":7,"programme":8,"title":279,"piName":14,"institution":280,"country":84,"year":13,"amount":14,"abstract":281},"cordis-european-research-council-award-615954","Multifunctional micro- and nanostructures assembled from nanoscale metal-organic frameworks and inorganic nanoparticles","FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA","In InanoMOF, we aim to develop frontier Supramolecular and Nanochemistry methodologies for the synthesis of a novel class of structures via controlled assembly of nanoscale metal-organic frameworks (nanoMOFs) and inorganic nanoparticles (INPs). These methods will embody the premise that “controlled object-by-object nano-assembly is a ground-breaking approach to explore for producing systems of higher complexity with advanced functions”. The resulting hybrid nanoMOF@INPs will marry the unique pro",{"id":283,"funder":7,"programme":8,"title":284,"piName":14,"institution":285,"country":66,"year":13,"amount":21,"abstract":286},"cordis-european-research-council-award-616891","Dynamic signalling networks in Diabetic Nephropathy (DN) – New avenues to a personalized therapy.-","UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF","Dynamic signalling networks in Diabetic Nephropathy (DN) – New avenues to a personalized therapy.-We have developed an exquisite experimental platform that facilitates the systematic unravelling of the signallingnetworks leading to (1) the initiation, (2) the progression and (3) the potential regeneration of podocytes inDN, paving the way to novel therapeutic strategies:(1) DN initiation: Identification of signalling cascades leading to microalbuminuria: MolecularBy combining transgenic Drosophi",{"id":288,"funder":7,"programme":8,"title":289,"piName":14,"institution":290,"country":46,"year":13,"amount":14,"abstract":291},"cordis-european-research-council-award-617472","Detection and understanding of landslides by observing and modelling gravitational flows and generated earthquakes","INSTITUT DE PHYSIQUE DU GLOBE DE PARIS","The goal of the project is to take a major step in improving the detection and understanding of landslides and their modelling at the field scale through the analysis of generated seismic waves. The seismic signal generated by landslides (i. e. landquakes) provides a unique tool to estimate the properties of the flow and its dynamics. Indeed, the stress applied by the landslide to the ground, which generates seismic waves, is highly sensitive to the flow history and therefore to the physical pro",{"id":293,"funder":7,"programme":8,"title":294,"piName":14,"institution":295,"country":296,"year":13,"amount":297,"abstract":298},"cordis-european-research-council-award-617001","Accreting binary populations in Nearby Galaxies: Observations and Simulations","IDRYMA TECHNOLOGIAS KAI EREVNAS","EL","€1,242,000","High-energy observations of our Galaxy offer a good, albeit not complete, picture of the X-ray source populations, in particular the accreting binary sources. Recent ability to study accreting binaries in nearby galaxies has shown that we would be short-sighted if we restricted ourselves to our Galaxy or to a few nearby ones. I propose an ambitious project that involves a comprehensive study of all the galaxies within 10 Mpc for which we can study in detail their X-ray sources and stellar popula",{"id":300,"funder":7,"programme":8,"title":301,"piName":14,"institution":302,"country":131,"year":13,"amount":303,"abstract":304},"cordis-european-research-council-award-617930","Eradication: the science and politics of a world without AIDS","FONDATION POUR L INSTITUT DE HAUTES ETUDES INTERNATIONALES ET DU DEVELOPPEMENT","€1,999,980","New biomedical technologies and public health strategies are being tested world-wide with the goal of eradicating the HIV epidemic. Achieving a world without AIDS has become the flagship of the vast global health apparatus, rallying governments, international organisations, philanthropic and pharmaceutical capital, research networks and activists. Mass screening and treatment, preventive drugs and gels, and molecular maps of sexual networks have shifted the biomedical paradigm from one of contro",{"id":306,"funder":7,"programme":8,"title":307,"piName":14,"institution":308,"country":154,"year":13,"amount":309,"abstract":310},"cordis-european-research-council-award-617451","Race Matter: On the Absent Presence of Race in Forensic Identification","UNIVERSITEIT VAN AMSTERDAM","€1,999,935","This ethnographic project on race in forensic practice aims to study how technologies of identification shape race. The focus is on ‘face-making’ in forensic identification; i.e. the reconstruction of faces of unknown persons, a practice entwined with ‘race-making’.In five subprojects the study investigates: How technologies of facial identification in and outside laboratories enact race (subprojects 1-3); How versions of race change as knowledge moves across sites (subproject 4); The mechanism ",{"id":312,"funder":7,"programme":8,"title":313,"piName":14,"institution":314,"country":60,"year":13,"amount":315,"abstract":316},"cordis-european-research-council-award-617107","Oxygen Sensing with Multimodality Imaging Probes","UNIVERSITY OF BATH","€1,886,876","This programme will employ physical sciences and biomedicine techniques to develop a revolutionary approach to early cancer diagnosis and post-treatment monitoring aiming to address shortcomings in our current technology in oxygen sensing and imaging of hypoxic prostate tumours.This proposal represents a gearing process towards the biomedical implementation of metal complexes and functionalised nanoparticles as novel synthetic platform systems for personalised diagnosis and treatment of diseases",{"id":318,"funder":7,"programme":8,"title":319,"piName":14,"institution":320,"country":66,"year":13,"amount":14,"abstract":321},"cordis-european-research-council-award-614765","The Molecular Anatomy of Neurons","UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS","The brain is nowadays the object of a number of extensive systematic studies that focus on seemingly all aspects of its morphology and function, from overall brain architecture to neuronal connections, neuronal morphology and gene expression. However, at least one basic aspect is as yet incompletely studied: the molecular anatomy of the neuron, i.e., the copy numbers and the spatial arrangement of molecules within the neuronal cell. This cannot be addressed by gene expression or proteomics appro",{"id":323,"funder":7,"programme":8,"title":324,"piName":14,"institution":325,"country":66,"year":13,"amount":326,"abstract":327},"cordis-european-research-council-award-614182","Design Principles of Ion Pairs in Organocatalysis – Elucidation of Structures, Intermediates and Stereoselection Modes as well as Assessment of Individual Interaction Contributions","UNIVERSITAET REGENSBURG","€1,994,685","Ions are nearly omnipresent in chemistry and biochemistry. By providing the highest intermolecular interaction energies, ionic interactions have an extreme impact on molecular structures, which are the key to molecular functions. Experimentally determined structures of small contact ion pairs in solution are very rare and sometimes lacking in complete research fields. In addition, despite the amazing progress in theoretical and supramolecular chemistry, the subtle interplay of interactions in sm",{"id":329,"funder":7,"programme":8,"title":330,"piName":14,"institution":331,"country":235,"year":13,"amount":332,"abstract":333},"cordis-european-research-council-award-617754","Harnessing the power of crowdsourcing to improve land cover and land-use information","INTERNATIONALES INSTITUT FUER ANGEWANDTE SYSTEMANALYSE","€1,397,200","Information about land cover, land use and the change over time is used for a wide range of applications such as nature protection and biodiversity, forest and water management, urban and transport planning, natural hazard prevention and mitigation, agricultural policies and monitoring climate change. Furthermore, high quality spatially explicit information on land cover change is an essential input variable to land use change modelling, which is increasingly being used to better understand the ",{"id":335,"funder":7,"programme":8,"title":336,"piName":14,"institution":217,"country":60,"year":13,"amount":337,"abstract":338},"cordis-european-research-council-award-615882","Inference for Semi-Nonparametric Econometric Models","€866,454","This research project aims to contribute to advances in the research on semiparametric and nonparametric econometric methods by developing novel estimation and inference approaches in a variety of contexts and applying them to important empirical problems in economics.The project is divided into four parts. The first part develops a Bayes procedure for the moment condition model. A likelihood function is constructed by employing an information theoretic projection from space of nonparametric pri",{"id":340,"funder":7,"programme":8,"title":341,"piName":14,"institution":342,"country":84,"year":13,"amount":343,"abstract":344},"cordis-european-research-council-award-617473","Pushing Myc inhibition towards the clinic","FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO)","€1,730,700","Deregulation of the Myc oncogene promotes tumorigenesis in most if not all cancers and is often associated with poor prognosis. However, targeting Myc has long been considered impossible because of potential catastrophic side effects in normal tissues. Despite this general assumption, we showed that Myc inhibition displays extraordinary therapeutic benefit in various transgenic mouse models of cancer, and caused only mild, well-tolerated and reversible side effects in normal tissues. For these s",{"id":346,"funder":7,"programme":8,"title":347,"piName":14,"institution":348,"country":66,"year":13,"amount":349,"abstract":350},"cordis-european-research-council-award-614507","Controlling the Motion of Complex Molecules and Particles","DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY","€1,982,500","The main objective of COMOTION is to enable novel experiments for the investigation of the intrinsic properties of large molecules, including biological samples like proteins, viruses, and small cells-X-ray free-electron lasers have enabled the observation of near-atomic-resolution structures in diffraction- before-destruction experiments, for instance, of isolated mimiviruses and of proteins from microscopic crystals. The goal to record molecular movies with spatial and temporal atomic-resoluti",{"id":352,"funder":7,"programme":8,"title":353,"piName":14,"institution":354,"country":154,"year":13,"amount":355,"abstract":356},"cordis-european-research-council-award-617700","Empowering expectations for health and disease: training the immune and endocrine system","UNIVERSITEIT LEIDEN","€1,981,009","Expectations about health and disease induce immune and endocrine responses and directly affect health and treatment outcomes. However, there is an urge to understand the mechanical underpinnings how expectations affect immune and endocrine responses and how this knowledge can be used for therapeutic interventions.My research group studies the main expectancy learning mechanisms for itch and pain as a generic expectancy model across symptoms and conditions. We recently showed that dual expectanc",{"id":358,"funder":7,"programme":8,"title":359,"piName":14,"institution":360,"country":66,"year":13,"amount":361,"abstract":362},"cordis-european-research-council-award-617989","Rational design of scaffold architecture and functionalization to induce healing and tissue regeneration","UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT","€1,994,200","When materials are implanted into the body they initiate an inflammatory response that is difficult to control. Consequently medical implants are tolerated by the body rather than fully integrated; the material is often sealed off from the body in a fibrotic capsule. Most recent research suggests that morphology is a decisive immunomodulatory trigger and may favor a healing-like reaction of the innate immune system, especially of macrophages.I have pioneered a single-step method to generate non-",{"id":364,"funder":7,"programme":8,"title":365,"piName":14,"institution":262,"country":263,"year":13,"amount":366,"abstract":367},"cordis-european-research-council-award-617516","Extremely Thin Absorbers for Solar Energy Conversion and Storage","€2,150,000","ETASECS aims at making a breakthrough in the development of photoelectrochemical (PEC) cells for solar-powered water splitting that can be readily integrated with PV cells to provide storage capacity in the form of hydrogen. It builds upon our recent invention for resonant light trapping in ultrathin films of iron oxide (a-Fe2O3), which enables overcoming the deleterious trade-off between light absorption and charge carrier collection efficiency. Although we recently broke the water photo-oxidat",{"id":369,"funder":7,"programme":8,"title":370,"piName":14,"institution":371,"country":66,"year":13,"amount":372,"abstract":373},"cordis-european-research-council-award-616777","Activation and Regulation of the NLRP3 Inflammasome","UNIVERSITATSKLINIKUM BONN","€1,995,906","The innate immune system protects the host from infections, detects and repairs tissue damage and functions to maintain tissue homeostasis. Several families of signaling receptors can recognize microbial substances or altered host molecules and orchestrate a coordinated inflammatory response. Inflammasomes are signaling platforms that control proteolytic activation of highly proinflammatory cytokines of the IL-1β family and thus, are relevant for infection control and numerous inflammatory condi",{"id":375,"funder":7,"programme":8,"title":376,"piName":14,"institution":308,"country":154,"year":13,"amount":377,"abstract":378},"cordis-european-research-council-award-616882","From Made in China to Created in China - A Comparative Study of Creative Practice and Production in Contemporary China","€1,947,448","With its emergence as a global power, China aspires to move from a “made in China” towards a “created in China” country. Creativity and culture have become a crucial source for innovation and financial growth, but are also mobilised to promote a new and open China to both the citizenry as well as the outside world. They are part of what is termed China’s “soft power.”What does creativity mean in the context of China, and what does it do? When both the state and profoundly globalised creative ind",{"id":380,"funder":7,"programme":8,"title":381,"piName":14,"institution":382,"country":66,"year":13,"amount":383,"abstract":384},"cordis-european-research-council-award-615132","Computational Modeling and Design of Lithium-Ion Batteries","BAUHAUS-UNIVERSITAET WEIMAR","€1,975,071","Lithium-ion batteries (LIBs) are among the most promising solutions for energy storage. Compared with other resources such as bio-fuel, solar cells, fuel cells or lead acid batteries, rechargeable batteries are more portable and allow for quick energy storage and release. The higher power and energy density make batteries suitable as the energy resource for most portable elect. devices including future vehicles. Among the rechargeable batteries, LIBs have the most potential because of their quic",{"id":386,"funder":7,"programme":8,"title":387,"piName":14,"institution":388,"country":235,"year":13,"amount":389,"abstract":390},"cordis-european-research-council-award-616160","Discrete Optimization in Computer Vision: Theory and Practice","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","€1,641,585","This proposal aims at developing new inference algorithms for graphical models with discrete variables, with a focus on the MAP estimation task. MAP estimation algorithms such as graph cuts have transformed computer vision in the last decade; they are now routinely used and are also utilized in commercial systems.Topics of this project fall into 3 categories.Theoretically-oriented: Graph cut techniques come from combinatorial optimization. They can minimize a certain class of functions, namely s",{"id":392,"funder":7,"programme":8,"title":393,"piName":14,"institution":394,"country":84,"year":13,"amount":395,"abstract":396},"cordis-european-research-council-award-617721","A new communication paradigm for future very high speed wireless networks","FUNDACION IMDEA NETWORKS","€1,719,960","Due to the tremendous growth in mobile devices such as smartphones, tablet PCs, and laptops over the past years, a larger and larger fraction of Internet traffic is delivered wirelessly. Dealing with this vast increase in traffic is one of the most important challenges for future wireless networks. State-of-the-art wireless communication already operates close to Shannon capacity. The only viable option to further increase data rates is to use high bandwidth channels in the very high frequency p",{"id":398,"funder":7,"programme":8,"title":399,"piName":14,"institution":400,"country":84,"year":13,"amount":401,"abstract":402},"cordis-european-research-council-award-614715","A Photo-triggered On-demand Drug Delivery System for Chronic Pain","UNIVERSIDAD DE ZARAGOZA","€1,570,091","Nerve pain affects millions of people, and can be personally devastating for people who experience it. Current methods for pain management (e.g. local injection of pain killers) are inadequate because of the short duration of action. Even sustained release treatments, such as drug-loaded liposomes, provide only one week of analgesia producing a continuous extended nerve blockade without allowing for changes in daily physical activity or level of pain relief. More importantly, such systems cannot",{"id":404,"funder":7,"programme":8,"title":405,"piName":14,"institution":223,"country":60,"year":13,"amount":406,"abstract":407},"cordis-european-research-council-award-614620","Exploiting the power of human induced pluripotent stem cells to generate synthetic retinae in vitro for cell based therapies, drug discovery and disease modelling","€1,599,857","Blindness represents an increasing global problem with social and economic impacts both for the patients and society in general.  Recent estimates indicate that the overall number of people with visual loss is 285 million globally, of whom 39 million are blind. In Europe, approximately 1 in 30 individuals experience sight loss and 75% of those are unemployed, a social burden which is anticipated to double by 2020 as the population of Europe ages. Diseases affecting the retina, the light sensitiv",{"id":409,"funder":7,"programme":8,"title":410,"piName":14,"institution":308,"country":154,"year":13,"amount":411,"abstract":412},"cordis-european-research-council-award-615117","Quantum-Degenerate Strontium: Mixtures, Molecules, and Many-Body Physics","€1,799,148","In 2009 my research team created the first Bose-Einstein condensate of strontium. This breakthrough is the foundation of my research program, which will investigate quantum many-body phenomena with a focus on quantum magnetism and physics related to the quantum Hall effect. We are especially interested in studying unusual, strongly correlated quantum states, among them states with topological order.The unique properties of strontium make it ideally suited to follow four different approaches to t",{"id":414,"funder":7,"programme":8,"title":415,"piName":14,"institution":416,"country":66,"year":13,"amount":417,"abstract":418},"cordis-european-research-council-award-616499","Global Dynamics of Proteolytic Quality Control Networks in Stress Response and Aging","UNIVERSITAT ZU KOLN","€1,992,960","Accumulation of damaged and aggregated proteins is associated with age-related neurodegeneration in Alzheimer’s and Parkinson’s patients. The ubiquitin\u002Fproteasome system (UPS) is a major proteolytic route functioning in a cellular network that maintains the proteome during stress and aging. Degradation of damaged proteins is mediated by the 26S proteasome upon attachment of ubiquitin (Ub) proteins (ubiquitylation). Another proteolytic system supporting protein homeostasis (proteostasis) is the a",{"id":420,"funder":7,"programme":8,"title":421,"piName":14,"institution":422,"country":66,"year":13,"amount":423,"abstract":424},"cordis-european-research-council-award-614278","Identifying Social-Ecological System Properties Benefiting Biodiversity and Food Security","LEUPHANA UNIVERSITAT LUNEBURG","€1,788,724","Ensuring food security and halting biodiversity decline are urgent, interconnected challenges. Drawing on the natural and social sciences, I propose an interdisciplinary research agenda to address these challenges. My goal is to develop a global theory that explains which properties of social-ecological systems benefit both biodiversity conservation and food security (and which benefit one but not the other). This holistic, systems-oriented approach radically differs from existing work: The most",{"id":426,"funder":7,"programme":8,"title":427,"piName":14,"institution":428,"country":66,"year":13,"amount":429,"abstract":430},"cordis-european-research-council-award-615613","External Quantum Control of Photonic Semiconductor Nanostructures","TECHNISCHE UNIVERSITAT BERLIN","€1,999,800","In this project, we will control photonic nanostructures by external feedback, optical injection and synchronization. This will allow us to study nonlinear dynamics in quantum systems and to externally manipulate and stabilize light-matter interaction in the regime of quantum electrodynamics (cQED). We will experimentally and theoretically address a) optical injection and feedback control of quantum dot (QD)–microlasers, b) quantum control cQED systems via delayed single photon feedback, and c) ",{"id":432,"funder":7,"programme":8,"title":433,"piName":14,"institution":434,"country":66,"year":13,"amount":435,"abstract":436},"cordis-european-research-council-award-615045","Medieval Philosophy in Modern History of Philosophy","ALBERT-LUDWIGS-UNIVERSITAET FREIBURG","€1,219,920","MEMOPHI plans the first comprehensive study of how eighteenth- and nineteenth-century historians of philosophy reconstructed medieval thought. Associating intellectual and cultural approaches, it investigates to what ends and how the history of medieval philosophy has been written, used and institutionalised in European institutions of knowledge. In the 18th and 19th centuries, history and philosophy were at the center of the scientific endeavour. Philosophy gave itself a history in the scientif",{"id":438,"funder":7,"programme":8,"title":439,"piName":14,"institution":440,"country":441,"year":13,"amount":14,"abstract":442},"cordis-european-research-council-award-615146","Functional analysis of uncultivated microbes using radioisotope probing","JYVASKYLAN YLIOPISTO","FI","Environmental microbiology calls for more advanced research methods for resolving microbial functions and regulation in environmental samples. The proposed project introduces an unconventional technology, radioisotope probing (RIP). This approach is based on the invention of radioactivity measurement via pH analysis. When the analysis of radioactivity is now combined with semiconductor sequencing, the technology offers two-dimensional analysis of millions of molecules on a sequencing chip. Hybri",{"id":444,"funder":7,"programme":8,"title":445,"piName":14,"institution":446,"country":46,"year":13,"amount":447,"abstract":448},"cordis-european-research-council-award-615274","Sequence similarity networks: a promising complement to the phylogenetic framework to study evolutionary biology","SORBONNE UNIVERSITE","€1,284,240","The comparison of molecular sequences from organisms, environmental samples and mobile genetic elements is fundamental in evolutionary biology to study genes, genomes and species evolution. Although phylogenetic methods play a major role in these analyses, through the inference of phylogenetic trees or networks based on families of homologous sequences, many data remained underexplored as the number of molecular sequences of interest exponentially grows, with typical environmental samples contai",{"id":450,"funder":7,"programme":8,"title":451,"piName":14,"institution":452,"country":84,"year":13,"amount":453,"abstract":454},"cordis-european-research-council-award-616434","Individual Robustness in Development and Cancer","FUNDACIO CENTRE DE REGULACIO GENOMICA","€1,996,812","Biological systems are robust to perturbations, with many genetic, stochastic and environmental challenges having no or little phenotypic consequence.  However, the extent of this robustness varies across individuals, for example the same mutation or treatment may only affect a subset of individuals.  The overall objective of this project is to understand the cellular and molecular mechanisms that confer this robustness and why it varies across individuals.We will address three specific question",{"id":456,"funder":7,"programme":8,"title":457,"piName":14,"institution":458,"country":263,"year":13,"amount":459,"abstract":460},"cordis-european-research-council-award-615564","Apartheid -- The Global Itinerary: South African Cultural Formations in Transnational Circulation, 1948-1990","THE HEBREW UNIVERSITY OF JERUSALEM","€1,861,238","This proposal proceeds from an anomaly. Apartheid routinely breached the separation that it names. Whereas the South African regime was deeply isolationist in international terms, new research links it to the Cold War and decolonization. Yet this trend does not consider sufficiently that the global contest over the meaning of apartheid and resistance to it occurs on the terrain of culture. My project argues that studying the global circulation of South African cultural formations in the aparthei",{"id":462,"funder":7,"programme":8,"title":463,"piName":14,"institution":458,"country":263,"year":13,"amount":91,"abstract":464},"cordis-european-research-council-award-615412","Understanding immune evasion by malaria parasites","The deadliest form of human malaria is caused by the protozoan parasite, Plasmodium falciparum, which annually infects millions worldwide. Its virulence is attributed to its ability to evade the human immune system, by modifying the host red blood cell surface to adhere to the vascular endothelium and to undergo antigenic variation. Antigenic variation is achieved through switches in expression of hypervariable surface ligands named PfEMP1. These proteins are encoded by a multi-copy gene family ",{"id":466,"funder":7,"programme":8,"title":467,"piName":14,"institution":458,"country":263,"year":13,"amount":91,"abstract":468},"cordis-european-research-council-award-616063","Functional diversity of single neurons in anatomically complex cortical networks","A fundamental quest in Neuroscience research is to reveal the function(s) of single neurons and networks. Understanding function seems to be on relatively solid grounds at the periphery where both anatomy and physiology converge in a simplified manner. However, as one ascends higher into the central nervous system, anatomy and physiology become increasingly more complex and functions become difficult to study. To reveal function, we will take a structure\u002Ffunction approach that synergizes between",{"id":470,"funder":7,"programme":8,"title":471,"piName":14,"institution":472,"country":263,"year":13,"amount":14,"abstract":473},"cordis-european-research-council-award-615172","High-Performance Secure Computation with Applications to Privacy and Cloud Security","BAR ILAN UNIVERSITY","Secure two-party and multiparty computation has long stood at the center of the foundations of theoretical cryptography. However, in the last five years there has been blistering progress on the question of efficient secure computation. We are close to the stage that secure computation can be applied to real-world privacy and security problems. There is thus considerable interest in secure computation solutions from governments, military and security organisations, and industry. However, in orde",{"id":475,"funder":7,"programme":8,"title":476,"piName":14,"institution":477,"country":46,"year":13,"amount":478,"abstract":479},"cordis-european-research-council-award-617432","Molecular signatures and Modulation of immunity to Adeno-Associated Virus vectors","ASSOCIATION GENETHON","€2,730,800","Experience with adeno-associated virus (AAV) vector-mediated gene transfer in human trials has unveiled the therapeutic potential of this approach, with some of the most exciting results coming from clinical studies of gene transfer for hemophilia B, congenital blindness, and the recent market approval of the first AAV-based gene therapy in Europe. Follow-up data of subjects treated with AAV vectors is showing sustained correction of the disease phenotype for several years after gene transfer, a",{"id":481,"funder":7,"programme":8,"title":482,"piName":14,"institution":483,"country":27,"year":13,"amount":484,"abstract":485},"cordis-european-research-council-award-615640","Frontiers of Extended Formulations","UNIVERSITE LIBRE DE BRUXELLES","€1,455,479","Linear programming has proved to be an invaluable tool both in theory and practice. Semidefinite programming  surpasses linear programming in terms of expressivity while remaining tractable. This project proposal investigates the modeling power of linear and semidefinite programming, in the context of combinatorial optimization. Within the emerging framework of extended formulations (EFs), I seek a decisive answer to the following question: Which problems can be modeled by a linear or semidefini",{"id":487,"funder":7,"programme":8,"title":488,"piName":14,"institution":483,"country":27,"year":13,"amount":14,"abstract":489},"cordis-european-research-council-award-616333","Defining the cellular dynamics leading to tissue expansion","Stem cells (SCs) ensure the development of the different tissues during morphogenesis, their physiological turnover during adult life and tissue repair after injuries. .Our lab has recently developed new methods to study by lineage tracing the cellular hierarchy that sustains homeostasis and repair of the epidermis and to identify distinct populations of SCs and progenitors ensuring mammary gland and prostate postnatal development.While quantitative clonal analysis combined with mathematical mod",{"id":491,"funder":7,"programme":8,"title":492,"piName":14,"institution":493,"country":131,"year":13,"amount":494,"abstract":495},"cordis-european-research-council-award-614768","Predicting environment-specific biotransformation of chemical contaminants","EIDGENOESSISCHE ANSTALT FUER WASSERVERSORGUNG ABWASSERREINIGUNG UND GEWAESSERSCHUTZ","€1,996,352","The ability to predict rates and products of microbial biotransformation for a broad variety of chemical contaminants accurately is essential not only for chemical risk management but also in the context of contaminated site remediation or the development of green chemical alternatives. Existing prediction methods, however, fall short of fulfilling these needs mostly because they base predictions on chemical structure only, disregarding the microbial communities responsible for degradation and t",{"id":497,"funder":7,"programme":8,"title":498,"piName":14,"institution":499,"country":84,"year":13,"amount":500,"abstract":501},"cordis-european-research-council-award-615608","New Methods and Applications for Forecast Evaluation","UNIVERSIDAD POMPEU FABRA","€501,860","Forecasting is a fundamental tool in Economics, Statistics, Business and other sciences. Judging whether forecasts are good and robust is of great importance since forecasts are used everyday to guide policymakers' and practitioners' decisions. The proposal aims at addressing four important issues that researchers encounter in practice.A first issue is how to assess whether forecasts are optimal in the presence of instabilities. Optimality is an important property of models’ forecasts: if foreca",{"id":503,"funder":7,"programme":8,"title":504,"piName":14,"institution":499,"country":84,"year":13,"amount":505,"abstract":506},"cordis-european-research-council-award-616960","Unravelling the unicellular prehistory of metazoans with functional analyses and single-cell genomics","€1,967,535","How multicellular animals (metazoans) emerged from their single-celled ancestor remains a long-standing evolutionary question. Recent genome data has shown that the unicellular ancestor of metazoans already had a complex gene repertoire for genes involved in cell adhesion, cell signaling and transcriptional regulation, including integrins, cadherins, T-box genes, and protein tyrosine kinases. Thus, besides a few metazoan-specific genes, gene co-option and, probably, an increase in gene regulatio",{"id":508,"funder":7,"programme":8,"title":509,"piName":14,"institution":510,"country":84,"year":13,"amount":511,"abstract":512},"cordis-european-research-council-award-617840","Investigating the causes and consequences of replication stress in mammalian health","FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III","€1,997,819","DNA damage (DD) is the cause of several diseases, including cancer, and it is also linked to the organ decline that arises in ageing. Yet, the contribution of different sources of DD to these processes is not understood. Sources of DD such as chromosome breaks, eroded telomeres or oxidative stress are been heavily investigated. For establishing my group, I decided to focus on a source of DD that arises every time a cell replicates its DNA, and which is known as replication stress (RS). In short,",{"id":514,"funder":7,"programme":8,"title":515,"piName":14,"institution":516,"country":66,"year":13,"amount":14,"abstract":517},"cordis-european-research-council-award-617462","A new approach to sequence Earth history at high resolution over the past 66 million years","UNIVERSITAET BREMEN","One major challenge to be addressed by this proposal is to overcome fundamental obstacles to generate a first high-resolution and continuous fully integrated record of geological events, ages and durations(a ‘sequence of Earth history’) for the past 66 million years, anchored to the present, to extract properties of Earth’s and solar system orbital motion, and then to apply this time scale to solve first order questions about Earth’s climate system and Earth System sensitivity. The project will ",{"id":519,"funder":7,"programme":8,"title":520,"piName":14,"institution":521,"country":39,"year":13,"amount":522,"abstract":523},"cordis-european-research-council-award-615089","Crystal channeling to extract a high energy hadron beam from an accelerator","ISTITUTO NAZIONALE DI FISICA NUCLEARE","€1,989,746","A new generation of parasitic beam extraction of high energy particles from an accelerator is proposed in CRYSBEAM. Instead of massive magnetic kickers, bent thin crystals trapping particles within the crystal lattice planes are used. This type of beam manipulation opens new fields of investigation of fundamental interactions between particles and of coherent interactions between particles and matter. An experiment in connection to Ultra High Energy Cosmic Rays study in Earth’s high atmosphere c",{"id":525,"funder":7,"programme":8,"title":526,"piName":14,"institution":527,"country":60,"year":13,"amount":528,"abstract":529},"cordis-european-research-council-award-616474","The Evolution of Cognitive Performance","THE UNIVERSITY OF EXETER","€1,450,000","I aim to determine how cognitive abilities evolve under natural selection; one of the most important, yet poorly understood issues in modern biology. Comparative studies inform us how species differ, and hence, one can infer selective pressures. However, studies of how heritable inter-individual cognitive differences determine fitness in the face of natural selection are absent. I will use methods and paradigms developed in comparative psychology, cognitive science and behavioural ecology, apply",{"id":531,"funder":7,"programme":8,"title":532,"piName":14,"institution":527,"country":60,"year":13,"amount":14,"abstract":533},"cordis-european-research-council-award-616179","Pre-Columbian Amazon-Scale Transformations","The protection of rainforests and the development of sustainable land-use practices in the humid tropics are of global significance because these forests represent a major reservoir of biodiversity and are of crucial importance for the regulation of Earth’s climate. A sound understanding of the historical role of humans in shaping Amazonian landscapes and to what extent Amazonian forests were resilient to historical disturbance is critical to make informed policy decisions about sustainable Amaz",{"id":535,"funder":7,"programme":8,"title":536,"piName":14,"institution":537,"country":131,"year":13,"amount":14,"abstract":538},"cordis-european-research-council-award-616830","Coactivator-controlled transcriptional networks regulating skeletal muscle cell plasticity","UNIVERSITAT BASEL","Regular physical activity is linked to improved health and increased life expectancy. Inversely, a sedentary life-style is a strong and independent risk factor for many chronic diseases, including obesity, type 2 diabetes or cardiovascular disorders, as well as certain types of cancer or neurodegeneration. Interestingly however, the molecular mechanisms that mediate the health beneficial effects of exercise, or those that trigger the pathological changes in diseases, are largely unknown.The tran",{"id":540,"funder":7,"programme":8,"title":541,"piName":14,"institution":537,"country":131,"year":13,"amount":14,"abstract":542},"cordis-european-research-council-award-616509","The organisation of functional microcircuits in visual cortex","Determining how the organisation of neural circuitry gives rise to its function has been a major challenge for understanding the neural basis of perception and behaviour. In order to uncover how different regions of the neocortex process sensory information, it is necessary to understand how the pattern and properties of synaptic connections in a specific sensory circuit determine the computations it performs. I propose to establish the relationship between synaptic connectivity and neuronal fun",{"id":544,"funder":7,"programme":8,"title":545,"piName":14,"institution":546,"country":263,"year":13,"amount":547,"abstract":548},"cordis-european-research-council-award-617445","Uncovering the molecular and cellular mechanism of tumor dormancy for the rational design of theranostic nanomedicines","TEL AVIV UNIVERSITY","€2,255,920","Tumor progression is dependent on a number of sequential steps, including initial tumor-vascular interactions and recruitment of blood vessels, as well as an established interaction of tumor cells with their surrounding microenvironment. Failure of a microscopic tumor, either primary, recurrent or metastatic, to complete one or more of these early stages may lead to delayed clinical manifestation of the cancer and a state of stable non-progressing disease. Micrometastasis, dormant tumors, and re",{"id":550,"funder":7,"programme":8,"title":551,"piName":14,"institution":552,"country":131,"year":13,"amount":553,"abstract":554},"cordis-european-research-council-award-614739","Anthelmintic Research and Optimization","SCHWEIZERISCHES TROPEN UND PUBLIC HEALTH INSTITUT","€1,927,350","I propose an ambitious, yet feasible 6-year research project that will fill an important gap in global health. Specifically, I will develop and validate novel approaches for anthelmintic drug discovery and development. My proposal pursues the following five research questions: (i) Is a chip calorimeter suitable for high-throughput screening in anthelmintic drug discovery? (ii) Is combination chemotherapy safe and more efficacious than monotherapy against strongyloidiasis and trichuriasis? (iii) ",{"id":556,"funder":7,"programme":8,"title":557,"piName":14,"institution":558,"country":84,"year":13,"amount":559,"abstract":560},"cordis-european-research-council-award-613694","The Latin Talmud and its Influence on Christian-Jewish Polemic","UNIVERSITAT AUTONOMA DE BARCELONA","€1,292,700","While polemics and dialogue between Judaism and Christianity are as old as the Christian religion itself, one can clearly distinguish different periods, trends and intensities in the relations between the faiths. A significant landmark in this long and complex history is the Latin translation of large sections of the Talmud, the most important Jewish post-biblical text and the basis for the development of Rabbinic Judaism.When during the 13th century Christian theologians started to examine and ",{"id":562,"funder":7,"programme":8,"title":563,"piName":14,"institution":564,"country":46,"year":13,"amount":565,"abstract":566},"cordis-european-research-council-award-616103","Inclusive rights: A new model to organise legal relations to shared resources in tangible property and intellectual property","FONDATION NATIONALE DES SCIENCES POLITIQUES","€1,361,382","The INCLUSIVE project aims at challenging our very perspective of property by adding an innovative notion, the ‘inclusive right’, in the toolbox of legal and economic theory. Whereas exclusivity is conventionally considered as the core element and purpose of property right, sharing and collectively using resources, either tangible or intellectual, is an increasing practice and a new field of research in the legal, sociological, cultural and economic academy. From public domain in copyright, the ",{"id":568,"funder":7,"programme":8,"title":569,"piName":14,"institution":570,"country":39,"year":13,"amount":571,"abstract":572},"cordis-european-research-council-award-616563","Highly accurate Isogeometric Method","UNIVERSITA DEGLI STUDI DI PAVIA","€928,188","Partial Differential Equations (PDEs) are widely used  in science and engineering simulations, often in tight connection with  Computer Aided Design (CAD). The Finite Element Method (FEM) is one of  the most popular technique for the discretization of PDEs. The IsoGeometric Method (IGM), proposed in 2005 by T.J.R. Hughes et al.,  aims at improving the interoperability between CAD and FEMs. This is achieved by adopting the CAD mathematical primitives, i.e. Splines and Non-Uniform Rational B-Splin",{"id":574,"funder":7,"programme":8,"title":575,"piName":14,"institution":576,"country":84,"year":13,"amount":577,"abstract":578},"cordis-european-research-council-award-617337","Quantum Information Theory with black BOXes","FUNDACIO INSTITUT DE CIENCIES FOTONIQUES","€1,487,505","With QITBOX we aim to develop a novel device-independent framework for quantum information processing. In this framework, devices are seen as black boxes that only receive inputs and produce outputs. Our main objective is to understand what can and cannot be done for information processing using only the observed correlations among the devices. We will structure our effort along three main research lines: (i) Characterization of quantum correlations: the general objective will be to characterize",{"id":580,"funder":7,"programme":8,"title":581,"piName":14,"institution":582,"country":583,"year":13,"amount":584,"abstract":585},"cordis-european-research-council-award-617639","A New Paradigm for Public Health Surveillance: Unlocking the Potential of Data to Empower Women and Health Systems","FOLKEHELSEINSTITUTTET","NO","€2,212,136","Rationale: State of the art health registries, cornerstones of public health surveillance, have hardly capitalized on the information and communication technology revolution. Many continue to be static, fragmented, and passive data repositories disseminating outdated reports only to a closed loop of public health officials.Aim: In a radical departure from traditional science, this proposal introduces a new paradigm for public health surveillance: Maximizing the potential of data by disseminating",{"id":587,"funder":7,"programme":8,"title":588,"piName":14,"institution":589,"country":154,"year":13,"amount":91,"abstract":590},"cordis-european-research-council-award-615708","MicroRNA function in cardiac and metabolic disease","KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW","Cardiovascular disease is the primary cause of morbidity and mortality worldwide. Despite numerous treatment options the prevalence of cardiovascular indications continues to increase, underscoring the need for new therapeutic strategies.In recent years, prominent roles of microRNAs (miRNAs) have been uncovered in a variety of cardiovascular disorders. miRNAs are short, single stranded RNAs that regulate gene expression by suppressing multiple, often related, mRNAs.Our studies have focussed on t",{"id":592,"funder":7,"programme":8,"title":593,"piName":14,"institution":594,"country":154,"year":13,"amount":595,"abstract":596},"cordis-european-research-council-award-615300","Mechanistic insights into the impact of tumor-associated neutrophils on metastatic breast cancer","STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS","€1,999,360","Metastatic disease is still largely unexplored, poorly understood and incurable. Accumulating evidence indicates that cells and mediators of the immune system can facilitate metastasis. Neutrophil accumulation in cancer patients has been associated with metastasis formation. In mouse tumor models, neutrophils have been reported to be pro- or anti- metastatic, but the underlying mechanisms involved in either function remain largely elusive. This proposal outlines a research program aimed at resol",{"id":598,"funder":7,"programme":8,"title":599,"piName":14,"institution":600,"country":39,"year":13,"amount":155,"abstract":601},"cordis-european-research-council-award-617629","Transfer Learning within and between brains","UNIVERSITA DEGLI STUDI DI TRENTO","The neural bases of adaptive behavior in social environments are far from being understood. We propose to use both computational and neuroscientific methodologies to provide new and more accurate models of learning in interactive settings. The long-term objective is to develop a neural theory of learning: a mathematical framework that describes the computations mediating social learning in terms of neural signals, structures and plasticity. We plan to develop a model of adaptive learning based o",{"id":603,"funder":7,"programme":8,"title":604,"piName":14,"institution":605,"country":66,"year":13,"amount":14,"abstract":606},"cordis-european-research-council-award-614733","Deformation Spaces of Geometric Structures","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","Moduli spaces of flat bundles and representation varieties play a prominent role in various areas of mathematics. Historically such spaces first arose in the study of systems of analytic differential equations. Closely related, and in fact locally homeomorphic, are deformation spaces of locally homogeneous geometric structures. Such deformation spaces often arise as solutions to basic geometric problems, and their global properties provide powerful topological invariants, in particular for three",{"id":608,"funder":7,"programme":8,"title":609,"piName":14,"institution":610,"country":60,"year":13,"amount":611,"abstract":612},"cordis-european-research-council-award-614290","Exploiting 17O NMR Spectroscopy: Atomic-Scale Structure, Disorder and Dynamics in Solids","THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS","€1,902,188","The fundamental importance of oxide-based systems in technology, energy materials, geochemistry and catalysis, and the presence of oxygen in many biomaterials, should have resulted in oxygen nuclear magnetic resonance (NMR) spectroscopy emerging as a vital tool for materials characterization. NMR offers an element-specific, atomic-scale probe of the local environment, providing a potentially powerful probe of local structure, disorder and dynamics in solids. However, despite the almost ubiquitou",{"id":614,"funder":7,"programme":8,"title":615,"piName":14,"institution":610,"country":60,"year":13,"amount":616,"abstract":617},"cordis-european-research-council-award-614779","GenoChemetics: Gene eXpression enabling selective Chemical functionalisation of natural products","€1,981,272","We aim to consolidate a trans-disciplinary research programme in which synthetic biology is harnessed to enable synthetic chemistry. We will utilise this approach to expeditiously access series of previously intractable natural product analogues.There is an urgent need for the discovery and development of new drugs and in particular new antibiotics. More than 13 million lives worldwide are currently claimed each year due to infectious diseases. Natural products provide an unparalleled starting p",{"id":619,"funder":7,"programme":8,"title":620,"piName":14,"institution":621,"country":60,"year":13,"amount":622,"abstract":623},"cordis-european-research-council-award-616938","Arctic sea ice, biogeochemistry and impacts on the atmosphere: Past, present, future","UNIVERSITY OF EAST ANGLIA","€1,192,911","The Arctic Ocean is a vast expanse of sea ice. Most of it is snow covered as are large continental regions for about half of the year. However, Global Change is arguably greatest in the Arctic, where temperatures have risen more than anywhere else in the last few decades. New record lows occurred in snow extent in June 2012 and sea ice extent in September 2012. Many observations show that widespread and sustained change is occurring in the Arctic driving this unique environmental system into a n",{"id":625,"funder":7,"programme":8,"title":626,"piName":14,"institution":627,"country":131,"year":13,"amount":628,"abstract":629},"cordis-european-research-council-award-617805","Lightweight Verification of Software","UNIVERSITA DELLA SVIZZERA ITALIANA","€1,999,320","As illustrated through the advent of cloud computing, cyberphysical systems, or the Internet of Things, more and more applications are inherently distributed. At the same time, programming distributed systems is notoriously hard. Programmers have to deal with asynchrony and have to cater for partial failures -- the possibility that certain communication(s), processes, or hosts fail while others remain operational. These failures can have drastic consequences such as the missing to react to criti",{"id":631,"funder":7,"programme":8,"title":632,"piName":14,"institution":633,"country":441,"year":13,"amount":14,"abstract":634},"cordis-european-research-council-award-617965","Intergenerational Cumulative Disadvantage and Resource Compensation","TURUN YLIOPISTO","The previous literature has not been able to successfully explain why the loss of the certain family resources does not show as a weaker attainment. Neither the country differences in socioeconomic inheritance seem to reflect the institutional differences between them. We argue that these problems have followed from ignoring resource compensation. The lost capital (economic, human\u002Fcultural or social) may be replaced with the other types or with the resources of someone else (the new or extended ",{"id":636,"funder":7,"programme":8,"title":637,"piName":14,"institution":633,"country":441,"year":13,"amount":638,"abstract":639},"cordis-european-research-council-award-615258","Adhesion switches in cancer and development: from in vivo to synthetic biology","€1,887,910","Integrins are transmembrane cell adhesion receptors controlling cell proliferation and migration. Our objective is to gain fundamentally novel mechanistic insight into the emerging new roles of integrins in cancer and to generate a road map of integrin dependent pathways critical in mammary gland development and integrin signalling thus opening new targets for therapeutic interventions. We will combine an in vivo based translational approach with cell and molecular biological studies aiming to i",{"id":641,"funder":7,"programme":8,"title":642,"piName":14,"institution":643,"country":60,"year":13,"amount":644,"abstract":645},"cordis-european-research-council-award-617313","PAst Links in the Evolution of Ocean’s Global ENvIronment and Ecology","UNIVERSITY OF BRISTOL","€1,930,472","Species do not live in isolation, but adapt and ultimately, evolve, in relationship with other species as well as with their chemical and physical environment. In the marine environment, this interaction is intimately two-way – the surface biogeochemical environment modulates the makeup of the pelagic ecosystem, yet at the same time, the ecosystem assemblage, by setting the strength of the biological pump and ultimately, in regulating the carbon and nutrient inventory of the ocean and atmospheri",{"id":647,"funder":7,"programme":8,"title":648,"piName":14,"institution":643,"country":60,"year":13,"amount":649,"abstract":650},"cordis-european-research-council-award-617266","Nano-Particle-Resolved Studies","€2,336,887","Amorphous materials may be classified into three types – thermodynamically stable liquids, metastable (supercooled) liquids and solid glasses. The second type represents the meeting point of many of the great challenges of statistical physics and materials science. What is the mechanism of dynamical arrest, by which structural relaxation become progressively inhibited upon cooling from a liquid to a glass? Can we develop physical pictures of the sequence of fluctuations associated with irreversi",{"id":652,"funder":7,"programme":8,"title":653,"piName":14,"institution":654,"country":60,"year":13,"amount":655,"abstract":656},"cordis-european-research-council-award-615897","Behaviour near criticality","UNIVERSITY OF WARWICK","€1,526,234","One of the main challenges of modern mathematical physics is to understand the behaviour of systems at or near criticality. In a number of cases, one can argue heuristically that this behaviour should be described by a nonlinear stochastic partial differential equation. Some examples of systems of interest are models of phase coexistence near the critical temperature, one-dimensional interface growth models, and models of absorption of a diffusing particle by random impurities. Unfortunately, th",{"id":658,"funder":7,"programme":8,"title":659,"piName":14,"institution":660,"country":60,"year":13,"amount":661,"abstract":662},"cordis-european-research-council-award-615834","Excited state quantum dynamics in molecular aggregates: a unified description from biology to devices","THE UNIVERSITY OF LIVERPOOL","€1,512,873","The coherent dynamics of excitons in systems of biological interest and in organic materials can now be studied with advanced experimental techniques, including two dimensional electronic spectroscopy, with time resolution of few femtoseconds. The theory of open quantum systems, that should support the interpretation of these new experiments, has been developed in different contexts over the past 60 years but seems now very inadequate for the problems of current interest.  First of all, the syst",{"id":664,"funder":7,"programme":8,"title":665,"piName":14,"institution":654,"country":60,"year":13,"amount":666,"abstract":667},"cordis-european-research-council-award-615142","Developing sequence controlled polymers for organization, templation and recognition","€2,324,271","Nature‘s toolbox for replication uses DNA and RNA which are nucleic acids capable of templating new copies of themselves. Nature‘s ability to replicate has led to the evolution of a wide variety of forms and functions for biological materials which cannot be achieved using current synthetic approaches. It seems likely that if we were able to teach plastics or other polymers how to template new copies of themselves that we would similarly be able to make new, impossible materials and hence furthe",{"id":669,"funder":7,"programme":8,"title":670,"piName":14,"institution":654,"country":60,"year":13,"amount":671,"abstract":672},"cordis-european-research-council-award-616797","3D Euler, Vortex Dynamics and PDE","€1,182,858","This proposal deals with a collection of problems in PDE arising from fluid mechanics.The primary motivation is the understanding of the evolution of isolated vortex lines for 3D Euler. The importance of the evolution of vorticity in incompressible fluid mechanics is very well known.To date, only nonrigorous approaches are known to try to obtain an evolution equation for isolated vortex lines. Two desingularization procedures are carried out (including a time renormalization) to obtain an evolut",{"id":674,"funder":7,"programme":8,"title":675,"piName":14,"institution":676,"country":60,"year":13,"amount":677,"abstract":678},"cordis-european-research-council-award-614562","Mitochondria as regulators of fungal virulence","THE UNIVERSITY OF BIRMINGHAM","€1,991,629","Fungal diseases represent a significant and growing threat to human health, particularly since the AIDS pandemic and increasing use of immunosuppressive drugs has produced a massive population of people with impaired immunity who are vulnerable to fungal infections.  A great challenge in medical mycology is to understand how fungal virulence evolves. The vast majority of fungal species are not human pathogens and, for those that are, virulence appears to have evolved independently on many differ",{"id":680,"funder":7,"programme":8,"title":681,"piName":14,"institution":676,"country":60,"year":13,"amount":682,"abstract":683},"cordis-european-research-council-award-614787","Surface-Based Molecular Imprinting for Glycoprotein Recognition","€1,894,046","There is now overwhelming evidence that glycosylation changes during the development and progression of various malignancies. Altered glycosylation has been implicated in cancer, immune deficiencies, neurodegenerative diseases, hereditary disorders and cardiovascular diseases. Currently, antibodies are playing a central role in enabling the detection of glycoprotein biomarkers using a variety of immunodiagnostic tests. Nonetheless, antibodies do have their own set of drawbacks that limit the com",{"id":685,"funder":7,"programme":8,"title":686,"piName":14,"institution":687,"country":154,"year":13,"amount":688,"abstract":689},"cordis-european-research-council-award-616675","Topological Josephson devices as a novel platform for creating and controlling non-Abelian anyons","UNIVERSITEIT TWENTE","€1,999,200","Surprisingly, in two-dimensional systems quasi-particles may exist that are neither fermions nor bosons. When these particles are interchanged, their joint quantum mechanical wave function is predicted to pick up any phase in between 0 (as for bosons) and pi (as for fermions), hence the name anyons.Even more intriguing is the class of non-Abelian anyons where interchange of particles completely changes the ground state of the system. This phenomenon lays at the heart of a wealth of theoretical p",{"id":691,"funder":7,"programme":8,"title":692,"piName":14,"institution":687,"country":154,"year":13,"amount":693,"abstract":694},"cordis-european-research-council-award-616918","Soft Wetting","€1,782,000","The physics of wetting, where a thin layer of fluid covers a solid substrate, finds numerous applications both in nature and industry. While one usually considers the substrate to be perfectly rigid, in many practically important circumstances the surface exhibits strong elastic deformations. Examples of such “Soft Wetting” phenomena are drops spreading on a gel, or roller bearings under heavy loads. Given the increasing technology to control and tune properties of soft matter, there is a strong",{"id":696,"funder":7,"programme":8,"title":697,"piName":14,"institution":687,"country":154,"year":13,"amount":698,"abstract":699},"cordis-european-research-council-award-616907","Chemistry in the Confinement of Protein Cages","€1,994,400","Protein cages appear to be common structures in biology, found in viruses but also in organelle-like containers discovered in bacteria. In this proposed program I aim to study chemical processes in nano-sized protein cages as mimics of bacterial organelles and to increase the general understanding of chemistry in confinement.Towards this goal we will investigate the controlled in vivo loading of bacterial protein cages, i.e. encapsulins, with proteins and enzymes. This will allow us to study in ",{"id":701,"funder":7,"programme":8,"title":702,"piName":14,"institution":703,"country":263,"year":13,"amount":704,"abstract":705},"cordis-european-research-council-award-615217","An artificial water-soluble photosystem by protein design","MIGAL GALILEE RESEARCH INSTITUTE LTD","€1,997,944","This project aims at producing a fully functional light energy conversion system that is inspired by, but does not necessarily mimic, the fundamental solar energy conversion unit of natural photosynthesis – the photosystem. This is a formidable challenge that can be met with thorough understanding of biological energy and electron transfer processes, and the growing capabilities of computational protein design. Here, this knowledge and capabilities will be further developed and utilized for the ",{"id":707,"funder":7,"programme":8,"title":708,"piName":14,"institution":709,"country":84,"year":13,"amount":14,"abstract":710},"cordis-european-research-council-award-617457","Phylogeography and somatic evolution of cancer tumor cells","UNIVERSIDAD DE VIGO","By far, most evolutionary research has focused on the changes that occur in the germline of individuals across generations, within and between species. For different reasons, much less attention has been given to the process of change within the somatic line of a multicellular individual. The formation of cancer tumors due to uncontrolled cell proliferation is one of the most prominent forms of somatic evolution. The evolution of cancer tumors in a body can be likened with the evolution of popul",{"id":712,"funder":7,"programme":8,"title":713,"piName":14,"institution":676,"country":60,"year":13,"amount":714,"abstract":715},"cordis-european-research-council-award-616358","Pragmatic and epistemic role of factually erroneous cognitions and thoughts","€1,900,075","The project will investigate pragmatic and epistemic benefits of delusional beliefs, distorted memories and confabulatory explanations in the context of normal and abnormal cognition. The notion of epistemic innocence will be developed to capture an unexplored phenomenon, the existence of cognitions whose overall epistemic benefits, in terms of enabling the acquisition or preservation of knowledge, outweigh their epistemic faults.",{"id":717,"funder":7,"programme":8,"title":718,"piName":14,"institution":719,"country":200,"year":13,"amount":91,"abstract":720},"cordis-european-research-council-award-614264","Magnetic fields and the outflows during the formation and evolution of stars","CHALMERS TEKNISKA HOGSKOLA AB","The outflows of young and old stars play a crucial role in the cycle of matter in galaxies.  Stars and planetary systems are formed through complex physical processes during the collapse of gas clouds with outflows a required ingredient. At the end of a stars life, stellar outflows are the main source of heavy elements that are essential for the formation of stars, planets and life. Magnetic fields are one of the key factors governing the in particular the often observed collimated outflow. They",{"id":722,"funder":7,"programme":8,"title":723,"piName":14,"institution":724,"country":39,"year":13,"amount":725,"abstract":726},"cordis-european-research-council-award-616213","Neuro-Plasmonics","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","€1,388,000","Research neuronal signaling is the subject of a very large community, but progresses face a dense multi-scale dynamics involving signaling at the molecular, cellular and large neuronal network levels. Whereas the brain capabilities are most likely emerging from large neuronal networks, available electrophysiological methods limit our access to single cells and typically provides only a fragmented observation, on limited spatial\u002Ftemporal scales. Therefore, broadening the spectrum of scales for ob",{"id":728,"funder":7,"programme":8,"title":729,"piName":14,"institution":730,"country":60,"year":13,"amount":14,"abstract":731},"cordis-european-research-council-award-615030","Soft and Small: Acoustic Transducers Inspired by Nature","UNIVERSITY OF STRATHCLYDE","The use of sound by humanity is ubiquitous. We utilise sound across a far greater range than we can hear for numerous extremely beneficial tasks. In Nature many animals have evolved ears, many of which are sensitive to sounds beyond human audibility. This includes an enormous variety of insects whose miniature ears detect sound to communicate, to detect their prey, or to avoid their own predators. Over recent years our understanding of the different insect ear functions, such as frequency filter",{"id":733,"funder":7,"programme":8,"title":734,"piName":14,"institution":724,"country":39,"year":13,"amount":735,"abstract":736},"cordis-european-research-council-award-614897","Advancing the Study of Chemical, Structural and Surface Transformations in Colloidal Nanocrystals","€2,430,720","Colloidal inorganic nanocrystals (NCs) are among the most investigated nanomaterials in Nanoscience due to their high versatility. Research on NCs went through much advancement lately, especially on synthesis, assembly and on the study of their transformations, most notably via cation exchange (all fields in which the PI has contributed already). However, the integration of NCs with fabrication tools that employ conditions such as irradiation, etching and annealing is at a very early stage since",{"id":738,"funder":7,"programme":8,"title":739,"piName":14,"institution":724,"country":39,"year":13,"amount":740,"abstract":741},"cordis-european-research-council-award-616695","Engineering Discoidal Polymeric Nanoconstructs for the Multi-Physics Treatment of Brain Tumors","€2,390,000","Despite significant advances in chemotherapy, the effective treatment of malignant masses via systemically injectable agents are still limited by insufficient accumulation at the biological target (\u003C\u003C 10% injected dose per gram tumor) and non-specific sequestration by the reticulo-endothelial system (tumor\u002Fliver \u003C 0.1).The goal of this proposal is to engineer Discoidal Polymeric Nanoconstructs (DPNs) to preferentially target the malignant neovasculature for the delivery of imaging agents, contro",{"id":743,"funder":7,"programme":8,"title":744,"piName":14,"institution":745,"country":66,"year":13,"amount":746,"abstract":747},"cordis-european-research-council-award-615074","Efficient Resource Constrained Cryptography","RUHR-UNIVERSITAET BOCHUM","€1,874,960","Traditionally, cryptographic protocols were run on servers or personal computers which have large and easily scalable computational resources. For these applications there exist a large variety of well-established cryptographic systems. Right now, we are in the midst of the shift toward ubiquitous computing on resource constrained devices (RCDs): small devices with severe constraints in terms of computing power, code size, and network capacities. RCDs are used virtually everywhere: smart phones,",{"id":749,"funder":7,"programme":8,"title":750,"piName":14,"institution":751,"country":27,"year":13,"amount":752,"abstract":753},"cordis-european-research-council-award-616702","Understanding contemporary interest group politics: mobilization and strategies in multi-layered systems","UNIVERSITEIT ANTWERPEN","€1,655,263","This ERC program addresses an unsettled political science problem, namely how does the shifting of policymaking competencies to higher levels of government affect the opportunities of societal interests to seek representation. On this issue two completely different theoretical expectations exist. One the one hand, the Madisonian view entails that shifting competencies upwards is a healthy antidote to the powers of specific interests that may dominate smaller polities. Multi-levelness may also pr",{"id":755,"funder":7,"programme":8,"title":756,"piName":14,"institution":757,"country":257,"year":13,"amount":758,"abstract":759},"cordis-european-research-council-award-615905","Targeting cancer using evolutionary refined pathogen derived antigens","KOBENHAVNS UNIVERSITET","€1,998,800","We have recently discovered a malaria protein which has shown a high potential in cancer treatment. In pregnant women, malaria infected red blood cells express a protein that binds to a distinct carbohydrate structure present only on cells of the maternal side of the placental circulation, but not elsewhere in the vasculature. This highly evolved binding system enables the parasite to evade clearance and infect placental tissue, causing pregnancy-associated malaria. This malaria protein binds to",{"id":761,"funder":7,"programme":8,"title":762,"piName":14,"institution":763,"country":764,"year":13,"amount":765,"abstract":766},"cordis-european-research-council-award-615574","Narrative Modes of Historical Discourse in Asia","UNIWERSYTET IM. ADAMA MICKIEWICZA WPOZNANIU","PL","€1,995,162","Modern historiography produced in Asia belongs to the history-paradigm of the European humanities and it is from within these epistemological confines that Western as well as Eastern scholars of Asian studies view the Asian writing of the past. While source criticism and historicism have today become key parts of historical consciousness in Asia, Asian historical representations are nonetheless firmly embedded in pre-modern Asian literary traditions via specific uses in historical writing of tra",{"id":768,"funder":7,"programme":8,"title":769,"piName":14,"institution":757,"country":257,"year":13,"amount":770,"abstract":771},"cordis-european-research-council-award-616236","Regulation of DNA damage responses at the replication fork","€1,996,356","This project aims at delineating the regulatory signaling processes that enable cells to overcome DNA damage during DNA replication, a major challenge to the integrity of the genome as the normal replication machinery is unable to replicate past DNA lesions. This may result in collapse of the replication fork, potentially giving rise to gross genomic alterations. To mitigate this threat, all cells have evolved DNA damage bypass strategies such as translesion DNA synthesis (TLS), involving low fi",{"id":773,"funder":7,"programme":8,"title":774,"piName":14,"institution":757,"country":257,"year":13,"amount":775,"abstract":776},"cordis-european-research-council-award-616027","Stardust to asteroids: Unravelling the formation and earliest evolution of a habitable solar system","€1,910,889","As far as we know, our solar system is unique. It could, in principle, be the only planetary system in the Universe to harbor intelligent life or, indeed, life at all. As such, attempting to reconstruct its history is one of the most fundamental pursuits in the natural sciences. Whereas astronomical observations of star- forming regions provide a framework for understanding the formation of low-mass stars and the early evolution of planetary systems in general, direct information about the earli",{"id":778,"funder":7,"programme":8,"title":779,"piName":14,"institution":780,"country":46,"year":13,"amount":781,"abstract":782},"cordis-european-research-council-award-617053","Novel radical chemistry for complex peptide synthesis and engineering","INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT","€1,984,218","Natural products are a constant source of inspiration in chemistry and have played a key role in the development of medicine. Recently, thanks to the progress in genomics and metagenomics, it has appeared that the biosynthetic potential of microorganisms and the complexity of the reactions catalyzed have been largely underestimated. Notably, enzymes using radical-based chemistry have been shown to be present in a very-large amount of biosynthetic pathways and to be widely distributed among all l",{"id":784,"funder":7,"programme":8,"title":785,"piName":14,"institution":786,"country":60,"year":13,"amount":787,"abstract":788},"cordis-european-research-council-award-616510","Engineering life: ideas, practices and promises","THE UNIVERSITY OF EDINBURGH","€1,559,389","The emerging field of synthetic biology promises to engineer the living world. This is potentially extremely contentious, so scholars from the social sciences and humanities have been incorporated into synthetic biology research programmes from the outset. The ENLIFE project’s distinctive contribution will be to study both the engineering of biology and the role of social scientists within this. Its two objectives are: to investigate the movement of ideas, practices and promises from engineering",{"id":790,"funder":7,"programme":8,"title":791,"piName":14,"institution":792,"country":27,"year":13,"amount":793,"abstract":794},"cordis-european-research-council-award-617312","A Single Cell AnaLysis and Sorting Platform based on Lensfree digital imaging techniques applied to Rapid Detection of Cancer","INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM","€1,999,840","Metastasis is responsible for > 90% of cancer-related deaths. Billions of dollars have been spent trying to cure primary tumors but very little was spent in trying to detect or kill the highly aggressive tumor cells that cause disease spreading.  One of the reasons is that single cell studies of rare cells in blood still present a large challenge.  Single cell analysis remains tedious with many different instruments and protocols, typically taking a few days of hands-on work.  This slows down re",{"id":796,"funder":7,"programme":8,"title":797,"piName":14,"institution":798,"country":46,"year":13,"amount":799,"abstract":800},"cordis-european-research-council-award-617196","Predictive electronic structure calculations for materials with strong electronic correlations: long-range Coulomb interactions and many-body screening","ECOLE POLYTECHNIQUE","€1,713,600","Materials with strong electronic Coulomb correlations present unique electronic properties such as exotic magnetism, charge or orbital order, or unconventional optical or transport properties, including superconductivity, thermoelectricity or metal-insulator transitions. The concerted behavior of the electrons in these ``correlated materials moreover leads to an extreme sensitivity to external stimuli such as changes in temperature, pressure, or external fields. This tuneability of even fundamen",{"id":802,"funder":7,"programme":8,"title":803,"piName":14,"institution":804,"country":27,"year":13,"amount":14,"abstract":805},"cordis-european-research-council-award-617779","Sparse Signal Coding for Interference-based Imaging Modalities","VRIJE UNIVERSITEIT BRUSSEL","Since its invention in 1948 by Dennis Gabor holography has held the promise to empower full parallax 3D visualisation. Though the trajectory has been significantly longer than expected, recent developments in photonics, microelectronics and computer engineering have led to the prospective to realize within a decade dynamic full parallax holography with acceptable rendering quality and viewing angle. Unfortunately projections – based on the current state-of-the-art and expected evolution in the u",{"id":807,"funder":7,"programme":8,"title":808,"piName":14,"institution":809,"country":39,"year":13,"amount":810,"abstract":811},"cordis-european-research-council-award-616155","Decentralized Markets with Informational Asymmetries","COLLEGIO CARLO ALBERTO - CENTRO DI RICERCA E ALTA FORMAZIONE","€827,410","The goal of this proposal is to advance the theory of decentralized trade with informational asymmetries and limited commitment.In most trading situations, some of the parties possess superior information about critical aspects of the environment. For example, in financial markets, professional investors are better informed about the quality of the assets that they sell to individuals. Similarly, consumers typically have private information about their willingness to pay for goods and services. ",{"id":813,"funder":7,"programme":8,"title":814,"piName":14,"institution":815,"country":39,"year":13,"amount":816,"abstract":817},"cordis-european-research-council-award-615879","G-quadruplexes in the HIV-1 genome: novel targets for the development of selective antiviral drugs","UNIVERSITA DEGLI STUDI DI PADOVA","€1,989,471","G-quadruplexes (G-4) are polymorphic nucleic acid structures identified in gene promoters where they act as transcription regulators. G-4s have been found in eukaryotic and prokaryotic organisms, while very little information is available on viruses. The applicant research group has recently shown that HIV-1, which integrates into the human chromosomes and exploits cellular factors to activate transcription, takes advantage of G-4-mediated transcription regulation. G-4 disruption stimulates prom",{"id":819,"funder":7,"programme":8,"title":820,"piName":14,"institution":815,"country":39,"year":13,"amount":821,"abstract":822},"cordis-european-research-council-award-615604","Solving the TP-AGB STAR Conundrum: a KEY to Galaxy Evolution","€1,930,628","Models of the Thermally Pulsing Asymptotic Giant Branch (TP-AGB) stellar evolutionary phase play a critical role across astrophysics, from the chemical composition of meteorites belonging to the pre-solar nebula up to galaxy evolution in the high-redshift Universe. In spite of its importance, the modelling of TP-AGB  is still affected by large uncertainties that propagate into the field of extragalactic astronomy, degrading the predicting power of current population synthesis models of galaxies.",{"id":824,"funder":7,"programme":8,"title":825,"piName":14,"institution":32,"country":60,"year":13,"amount":826,"abstract":827},"cordis-european-research-council-award-614328","Savings and Risks Over the Lifecycle: Theory and Evidence","€1,216,477","People save for many reasons, such as to finance their retirement, to leave bequests to others, to start and develop a business, and to self-insure against risks. When young, these risks include wage risk, unemployment risk, entrepreneurial risk, and divorce risk. When old, one risks living to a very old age and running out of assets, being hit by expensive medical needs, and losing one’s spouse. An important factor affecting people’s risk exposure, and hence saving behaviour, is the public insu",{"id":829,"funder":7,"programme":8,"title":830,"piName":14,"institution":32,"country":60,"year":13,"amount":831,"abstract":832},"cordis-european-research-council-award-617970","Making Selves, Making Revolutions: Comparative Anthropologies of Revolutionary Politics","€1,854,472","What kinds of self does it take to make a revolution? And how does revolutionary politics, understood as a project of personal as much as political transformation, articulate with other processes of self-making, such as religious practices? Comparative Anthropologies of Revolutionary Politics (CARP) seeks fundamentally to recast our understanding of revolutions, using their relationship to religious practices in diverse social and cultural settings as a lens through which to reveal revolutions’ ",{"id":834,"funder":7,"programme":8,"title":835,"piName":14,"institution":32,"country":60,"year":13,"amount":836,"abstract":837},"cordis-european-research-council-award-617119","Decoding Lights from Exotic Worlds","€2,080,502","It is now accepted that exoplanets are ubiquitous. However little is known about those planets we have detected beyond the fact they exist and their location. For a minority, we know their weight, size and orbital parameters. For less than twenty, we have some clues about their atmospheric temperature and composition. How do we progress from here?We are still far from a hypothetical Hertzsprung–Russell diagram for planets and we do not even know whether there ever will be such classification for",{"id":839,"funder":7,"programme":8,"title":840,"piName":14,"institution":160,"country":66,"year":13,"amount":155,"abstract":841},"cordis-european-research-council-award-616744","The histone H3.3 variant in brain cancer pathogenesis","Epigenetic reprogramming is a hallmark of brain cancer. Remarkably, driver mutations of the histone H3.3 variant and its loading machinery have been recently found in paediatric glioblastoma multiforme (GBM), a devastating neoplasm originating from transformed neural precursors. Thus, the very basic building blocks of chromatin can be mutated in cancer.The present challenge is to define at which level altered H3.3 loading influences GBM pathogenesis and provide clues into the underlying mechanis",{"id":843,"funder":7,"programme":8,"title":844,"piName":14,"institution":845,"country":60,"year":13,"amount":846,"abstract":847},"cordis-european-research-council-award-615596","Choices and consumption: modelling long and short term decisions in a changing world","UNIVERSITY OF LEEDS","€1,873,288","Mathematical models of choice behaviour are used to understand consumer decisions and valuations and forecast choices across a range of topic areas, including transport and regional science. Their outputs form a key component in guidance underpinning government and industry decisions on changes to policy, infrastructure developments or the introduction of new services or products. Given the significant financial, environmental and societal implications of such decisions, model accuracy is crucia",{"id":849,"funder":7,"programme":8,"title":850,"piName":14,"institution":851,"country":200,"year":13,"amount":852,"abstract":853},"cordis-european-research-council-award-616496","The Swedish historical database project","STOCKHOLMS UNIVERSITET","€1,200,000","The Swedish historical data base project will put together and make publicly available highly disaggregated data on roughly a yearly basis for about 2500 Swedish administrative districts over the period 1749-1952. The finished data set will consist of comprehensive and detailed information on economic activity, political characteristics, vital statistics, occupational structure, education, social and agriculture statistics and infrastructure investments (e.g., railway construction).  The compreh",{"id":855,"funder":7,"programme":8,"title":856,"piName":14,"institution":857,"country":235,"year":13,"amount":858,"abstract":859},"cordis-european-research-council-award-616920","Nanofiber Quantum Networks","TECHNISCHE UNIVERSITAET WIEN","€1,993,526","We propose to establish nanofiber-based atom-light interfaces as quantum-enabled fiber-optical components for quantum information processing and communication (QIPC). The key ingredient of this interface is a nanofiber-based optical dipole trap which stores laser-cooled atoms in the evanescent field surrounding the nanofiber. In this evanescently coupled atom-waveguide-system, even a few hundred atoms are already optically dense for near-resonant photons propagating through the nanofiber. In com",{"id":861,"funder":7,"programme":8,"title":862,"piName":14,"institution":863,"country":60,"year":13,"amount":864,"abstract":865},"cordis-european-research-council-award-617985","Photon-Spin Entanglement in Hybrid Cluster State Architectures","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€1,739,499","The last decade has witnessed quantum mechanics and information science merge for the debut of experimental quantum information processing. Despite the number of promising physical systems as candidates for quantum bits, scalability via a brute force approach faces serious technical obstacles. Developing distributed quantum networks is possibly the answer to the stringent demand of controllable interaction between high quality qubits. In these systems, the requirements are on the stationary qubi",{"id":867,"funder":7,"programme":8,"title":868,"piName":14,"institution":863,"country":60,"year":13,"amount":869,"abstract":870},"cordis-european-research-council-award-615584","Evolutionary genetics of transcription factor binding in closely related mammals","€1,910,107","The genetic differences found in gene regulatory regions are the largest contributing factor to the diversity of phenotypes within and between mammalian species. However, the micro-evolutionary mechanisms active in closely-related species remain poorly explored, particularly in mammals.In Aim 1, we will exploit five recently sequenced mouse species to determine how often genetic sequence differences alter both the genome-wide binding and regulatory output of a core set of tissue-specific transcr",{"id":872,"funder":7,"programme":8,"title":873,"piName":14,"institution":863,"country":60,"year":13,"amount":14,"abstract":874},"cordis-european-research-council-award-617391","Genius before Romanticism: Ingenuity in Early Modern Art and Science","Genius before Romanticism: Ingenuity in Early Modern Art and ScienceWhat existed in the European imagination before the Romantic concept of ‘genius’?  This five-year project will examine notions of unique talent, heightened imagination and extraordinary creativity in art and science by exploring the language, theories, practices and products of ingenium (ingenuity) ca. 1450-ca. 1750.  Drawing on the perspectives of history of art, history of science, technology and medicine, intellectual history",{"id":876,"funder":7,"programme":8,"title":877,"piName":14,"institution":863,"country":60,"year":13,"amount":878,"abstract":879},"cordis-european-research-council-award-617627","Adaptation, Dispersals and Phenotype: understanding the roles of climate,  natural selection and energetics in shaping global hunter-gatherer adaptability.","€1,911,485","Relative to other species, humans are characterised by considerable biological diversity despite genetic homogeneity. This diversity is reflected in skeletal variation, but we lack sufficient understanding of the underlying mechanisms to adequately interpret the archaeological record. The proposed research will address problems in our current understanding of the origins of human variation in the past by: 1) documenting and interpreting the pattern of global hunter-gatherer variation relative to",{"id":881,"funder":7,"programme":8,"title":882,"piName":14,"institution":863,"country":60,"year":13,"amount":883,"abstract":884},"cordis-european-research-council-award-617849","Epistemic intersections in early modern England: the place of literature","€1,996,743","This project uncovers the interface between imaginative literature and epistemology in its wider sense in early modern England (1500-1700). This period of intense literary production also saw the cultural forces of humanism and the Reformation collide; crucial shifts in the law; scientific advancement; and dramatic expansion in trade and travel. At stake across the board was knowledge: its theories and technologies, its excitements and anxieties. We examine intersections between literary forms a",{"id":886,"funder":7,"programme":8,"title":887,"piName":14,"institution":863,"country":60,"year":13,"amount":888,"abstract":889},"cordis-european-research-council-award-614966","Hydrodynamic Synchronisation in Model and Biological Systems","€1,261,572","Cilia and flagella beating in synchronised patterns give rise to metachronal waves, beautiful examples of emergent behaviour in biology. These collective dynamical states are essential in life, transporting nutrients and clearing pathogens; they arise from the mechanical interaction of individual cilia mediated by the viscous fluid.Severe pathologies are associated with cilia malfunction in humans. The current analysis of ciliated tissues in the clinic is focused purely on the frequency of beati",{"id":891,"funder":7,"programme":8,"title":892,"piName":14,"institution":780,"country":46,"year":13,"amount":893,"abstract":894},"cordis-european-research-council-award-615739","Mechanical signals in plants: from cellular mechanisms to growth coordination and patterning","€1,869,823","Development relies on a complex network of molecular effectors that ultimately modify the mechanical properties of cells and control shape changes. In turn, mechanical forces can also feedback on the molecular network to govern development. Several mechanosensitive proteins have been identified in animals but their role in multicellular development remains poorly documented. Plants are ideal systems to study mechanotransduction in development because their mechanics is mainly mediated by the cel",{"id":896,"funder":7,"programme":8,"title":897,"piName":14,"institution":32,"country":60,"year":13,"amount":14,"abstract":898},"cordis-european-research-council-award-617777","COLONISATION AND CULTURAL DIVERSIFICATION IN UNFAMILIAR LANDSCAPES","This project explores the relationship between climate change and human behaviour. During the harshest conditions of the last ice age European human populations abandoned northern latitudes, with their range contracting to southern regions. By the time ice sheets retreated and large areas of land became available for resettlement there had been a hiatus of at least 7000 years.  This project examines the recolonisation of these Northern regions which took place during a period of rapid climate ch",{"id":900,"funder":7,"programme":8,"title":901,"piName":14,"institution":902,"country":39,"year":13,"amount":903,"abstract":904},"cordis-european-research-council-award-617162","HSC-based therapies for LSDs: understanding the modalities of cell replacement in the LSD brain for improving therapeutic efficacy","OSPEDALE SAN RAFFAELE SRL","€1,751,147","The recent hypothesis that postnatal microglia are maintained independently of circulating monocytes by local precursors that colonize the brain before birth has relevant implications for the treatment of various neurological diseases, including lysosomal storage disorders (LSDs). LSDs are fatal diseases of childhood occurring in 1:5000-7000 live births; in >50% of the cases, LSD patients experience a severe neurological deterioration. Most LSDs with central nervous system (CNS) involvement lack",{"id":906,"funder":7,"programme":8,"title":907,"piName":14,"institution":908,"country":66,"year":13,"amount":909,"abstract":910},"cordis-european-research-council-award-616344","The Highly Efficient And Reliable smart Transformer (HEART), a new Heart for the Electric Distribution System","CHRISTIAN-ALBRECHTS-UNIVERSITAET  ZU KIEL","€1,996,720","In the last 10 years, power electronics has moved significantly towards the electric grid, making it more flexible and decentralized. Still important challenges remain. One of the most thrilling is re-inventing the distribution transformer after more than 125 years since its first use in the electrification of a city. In fact, actual distribution transformers can no longer fulfill the requirements of a modern electric grid highly dominated by distributed sources and new sizable loads, like heat ",{"id":912,"funder":7,"programme":8,"title":913,"piName":14,"institution":914,"country":60,"year":13,"amount":915,"abstract":916},"cordis-european-research-council-award-615929","Supernovae: Physics and Cosmology in the Next Decade","UNIVERSITY OF SOUTHAMPTON","€1,970,745","Exploding stars, or supernovae, impact upon many diverse areas of astrophysics, from galaxy formation, to stellar evolution, to cosmology and studies of dark energy. I am playing a leading role in new, wide-field, high-cadence optical surveys that are revolutionising the study of supernovae, searching vast volumes of space, locating hundreds of events to study their demographics in detail, and uncovering new and bizarre types of explosions. In concert with a major European Southern Observatory p",{"id":918,"funder":7,"programme":8,"title":919,"piName":14,"institution":920,"country":66,"year":13,"amount":921,"abstract":922},"cordis-european-research-council-award-615984","Protein Translocation Through Bacterial Syringes","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€1,999,992","The main objective of this application is to study the molecular basis of cellular infection by bacterial ABC-type toxins (Tc). Tc complexes are important virulence factors of a range of bacteria, including Photorhabdus luminescens and Yersinia pseudotuberculosis that infect insects and humans. Belonging to the class of pore-forming toxins, tripartite Tc complexes perforate the host membrane by forming channels that translocate toxic enzymes into the host.In our previous cryo-EM work on the P. l",{"id":924,"funder":7,"programme":8,"title":925,"piName":14,"institution":325,"country":66,"year":13,"amount":926,"abstract":927},"cordis-european-research-council-award-616052","NMR Spectroscopy of very large complexes: the atomic details of the mRNA degradation machinery","€1,966,800","The cellular environment is extremely complex and contains thousands of different bio-molecules. To determine how these bio-molecules assemble into a highly organized molecular system has remained a major challenge. Here, we aim to unravel how dozens of proteins assemble into a large molecular machinery that degrades mRNA in an efficient and regulated manner.On an atomic level, we will determine the static structures of the enzymes involved in the mRNA degradation pathways. In parallel, we will ",{"id":929,"funder":7,"programme":8,"title":930,"piName":14,"institution":920,"country":66,"year":13,"amount":931,"abstract":932},"cordis-european-research-council-award-617279","Recombination in Adaptive Evolution","€1,998,704","Meiotic recombination is a key source of genetic diversity with considerable implications for the genomic landscape and evolutionary process. By shuffling parental alleles to produce novel haplotypes, recombination impacts the strength of selection on nearby polymorphisms, and can increase the rate of adaptation in natural populations. Recombination defects can have serious phenotypic consequences: inviable gametes, miscarriages and developmental abnormalities. Strikingly, recombination rate dif",{"id":934,"funder":7,"programme":8,"title":935,"piName":14,"institution":920,"country":66,"year":13,"amount":91,"abstract":936},"cordis-european-research-council-award-616905","Non-Invasive In-Vivo Histology in Health and Disease Using Magnetic Resonance Imaging (MRI)","Understanding of the normal and diseased brain crucially depends on reliable knowledge of its microstructure. Important functions are mediated by small cortical units (columns) and even small changes in the microstructure can cause debilitating diseases. So far, this microstructure can only be determined using invasive methods such as, e.g., ex-vivo histology. This limits neuroscience, clinical research and diagnosis.My research vision is to develop novel methods for high-resolution magnetic res",{"id":938,"funder":7,"programme":8,"title":939,"piName":14,"institution":920,"country":66,"year":13,"amount":940,"abstract":941},"cordis-european-research-council-award-615414","Spectroscopic Studies of N2 Reduction: From Biological to Heterogeneous Catalysis","€1,989,600","The conversion of dinitrogen (N2) to ammonia (NH3) is of fundamental biological and economic importance. The catalytic conversion is achieved either industrially, using heterogeneous catalysts or biologically, by the nitrogenase enzyme. However, in both cases, the mechanistic details of the process are not fully understood. In order to design advance catalysts that will be essential for a sustainable energy economy, an in-depth understanding of both the biological and chemical mechanisms is requ",{"id":943,"funder":7,"programme":8,"title":944,"piName":14,"institution":920,"country":66,"year":13,"amount":945,"abstract":946},"cordis-european-research-council-award-616783","XUV\u002FX-ray Multidimensional Spectroscopy of Fundamental Electron Dynamics and Impulsive Control of X-ray Light","€1,983,863","Interaction of extreme&controlled light fields with matter is driving an ongoing revolution in our understanding of quantum physics.  Controlled—pulsed—visible lasers have enabled time-dependent two-dimensional (2D) spectroscopy currently transforming chemistry, and led to key milestones such as frequency combs.Despite progress on coherent soft- and hard-x-ray pulsed sources during the last 10 years—e.g. x-ray free-electron lasers (FELs) or high-harmonic generation of laser light, nonlinear (e.g",{"id":948,"funder":7,"programme":8,"title":949,"piName":14,"institution":950,"country":27,"year":13,"amount":14,"abstract":951},"cordis-european-research-council-award-615456","Innovative Catalyst Design for Large-Scale, Sustainable Processes","UNIVERSITEIT GENT","A systematic and novel, multi-scale model based catalyst design methodology will be developed. The fundamental nature of the models used is unprecedented and will represent a breakthrough compared to the more commonly applied statistical, correlative relationships. The methodology will focus on the intrinsic kinetics of (potentially) large-scale processes for the conversion of renewable feeds into fuels and chemicals. Non-ideal behaviour, caused by mass and heat transfer limitations or particula",{"id":953,"funder":7,"programme":8,"title":954,"piName":14,"institution":950,"country":27,"year":13,"amount":955,"abstract":956},"cordis-european-research-council-award-614839","Development trajectories of temperate forest plant communities under global change: combining hindsight and forecasting (PASTFORWARD)","€1,887,780","The last decades are characterized by an upsurge of research on the impacts of global environmental changes on forests. Climate warming, atmospheric deposition of acidifying and eutrophying pollutants and land-use change are three of the most important threats to biodiversity in temperate forests. However, most studies focused on the effects of single factors over short time periods, such that our ability to predict the combined effects of multiple global change drivers over longer time periods ",{"id":958,"funder":7,"programme":8,"title":959,"piName":14,"institution":950,"country":27,"year":13,"amount":960,"abstract":961},"cordis-european-research-council-award-615517","Formalizing Subjective Interestingness in Exploratory Data Mining","€1,549,315","The rate at which research labs, enterprises and governments accumulate data is high and fast increasing. Often, these data are collected for no specific purpose, or they turn out to be useful for unanticipated purposes: Companies constantly look for new ways to monetize their customer databases",{"id":963,"funder":7,"programme":8,"title":964,"piName":14,"institution":965,"country":66,"year":13,"amount":966,"abstract":967},"cordis-european-research-council-award-614606","Inorganic surfactants with multifunctional heads","UNIVERSITAT KONSTANZ","€1,863,546","Surfactants are molecules of enormous scientific and technological importance, which are widely used as detergents, emulsifiers or for the preparation of diverse nanostructures. Fascinating abilities regarding the formation of self-organized structures, like micelles or liquid crystals, originate from their amphiphilic architecture, which comprises a polar head group linked to a hydrophobic chain. While almost all known surfactants are organic, a new family of surfactants is now emerging, which ",{"id":969,"funder":7,"programme":8,"title":970,"piName":14,"institution":971,"country":60,"year":13,"amount":972,"abstract":973},"cordis-european-research-council-award-615075","Algorithms and Lower Bounds: A Unified Approach","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€1,274,496","One of the fundamental goals of theoretical computer science is tounderstand the possibilities and limits of efficient computation. Thisquest has two dimensions. Thetheory of algorithms focuses on finding efficient solutions toproblems, while computational complexity theory aims to understand whenand why problems are hard to solve. These two areas have differentphilosophies and use different sets of techniques. However, in recentyears there have been indications of deep and mysterious connection",{"id":975,"funder":7,"programme":8,"title":976,"piName":14,"institution":971,"country":60,"year":13,"amount":977,"abstract":978},"cordis-european-research-council-award-615040","Nomadic Empires: A World-Historical Perspective","€1,998,584","This project provides a wide-ranging and inclusive reinterpretation of the history of equestrian nomadic empires from the fourth century BCE to the late nineteenth century CE. The project has four major objectives that are interrelated. First, it expands the scope of the research significantly by extending it beyond the better known Eurasian nomadic empires into the Americas, where new research has revealed—and may yet reveal—previously unidentified nomadic empires. The project also re-examines ",{"id":980,"funder":7,"programme":8,"title":981,"piName":14,"institution":971,"country":60,"year":13,"amount":91,"abstract":982},"cordis-european-research-council-award-616449","The Proteolytic Machinery of the Plant Apoplast:from Basic Understanding to Improved Recombinant Protein Production","The plant proteolytic machinery involves over 700 proteases that control the (in)activation of proteins. Surprisingly, although every protein is regulated by proteolysis, only very few natural substrates of plant proteases have been identified, and the diverse roles of e.g. secreted proteases are still poorly understood. These questions have become even more urgent since glyco-engineered plants are increasingly used for the production of recombinant proteins (RPs) to produce therapeutic antibodi",{"id":984,"funder":7,"programme":8,"title":985,"piName":14,"institution":971,"country":60,"year":13,"amount":986,"abstract":987},"cordis-european-research-council-award-614727","The 15th-century Book Trade: An Evidence-based Assessment and Visualization of the Distribution, Sale, and Reception of Books in the Renaissance","€1,999,172","The idea that underpins this project is to use the material evidence from thousands of surviving 15th-c. books, as well as unique documentary evidence — the unpublished ledger of a Venetian bookseller in the 1480s which records the sale of 25,000 printed books with their prices — to address four fundamental questions relating to the introduction of printing in the West which have so far eluded scholarship, partly because of lack of evidence, partly because of the lack of effective tools to deal ",{"id":989,"funder":7,"programme":8,"title":990,"piName":14,"institution":971,"country":60,"year":13,"amount":991,"abstract":992},"cordis-european-research-council-award-614725","Pathogen Phylodynamics: Unifying Evolution, Infection and Immunity","€1,973,325","Genetic sequences represent a rich source of information about evolutionary and ecological processes in natural populations. However the development of methods to recover this information is being outpaced by the explosion in sequence data, especially since the introduction of ‘next-generation’ sequencing. This problem is particularly acute for the inter-disciplinary field of pathogen phylodynamics. The rapid evolution of many pathogens means their ecological and evolutionary dynamics occur on t",{"id":994,"funder":7,"programme":8,"title":995,"piName":14,"institution":971,"country":60,"year":13,"amount":996,"abstract":997},"cordis-european-research-council-award-617071","Rich, Structured and Efficient Learning of Big Bayesian Models","€1,918,092","As datasets grow ever larger in scale, complexity and variety, there is an increasing need for powerful machine learning and statistical techniques that are capable of learning from such data. Bayesian nonparametrics is a promising approach to data analysis that is increasingly popular in machine learning and statistics.  Bayesian nonparametric models are highly flexible models with infinite-dimensional parameter spaces that can be used to directly parameterise and learn about functions, densiti",{"id":999,"funder":7,"programme":8,"title":1000,"piName":14,"institution":1001,"country":131,"year":13,"amount":1002,"abstract":1003},"cordis-european-research-council-award-614577","High Impact Cross-section Calculations for Unprecedented Precision","ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE","€1,514,798","The first runs of the Large Hadron Collider (LHC) experiment just finished. The LHC was successful in discovering a particle compatible with the Higgs boson of the Standard Model (SM). However expectations to discover New Physics have not been met so far.In order to establish whether the new resonance is the SM Higgs boson, or not, precise measurements of its properties are mandatory. These require accurate predictions for cross-sections involving the Higgs boson, as well as for SM backgrounds, ",{"id":1005,"funder":7,"programme":8,"title":1006,"piName":14,"institution":971,"country":60,"year":13,"amount":1007,"abstract":1008},"cordis-european-research-council-award-617306","ADVANCED STATISTICAL METHODS FOR HIGH-DIMENSIONAL GENETIC STUDIES","€1,627,906","Statistical methods play a central role in the field of modern genetics. New technologies are driving an explosion of high-dimensional datasets that will sustain a continuing need for new methods, theory and computationally efficient software. My proposal has two parts that will address the statistical challenges and creation of resources at the frontier of the science in this area. The methods development will be driven by, and applied to, several cutting-edge datasets in the fields of human di",{"id":1010,"funder":7,"programme":8,"title":1011,"piName":14,"institution":971,"country":60,"year":13,"amount":1012,"abstract":1013},"cordis-european-research-council-award-615945","Peptide padlocks evolved towards infinite affinity for antibody nanoassembly and ultrasensitive cell capture","€1,616,328","Our ability to tailor individual proteins is now sophisticated, but our ability to assemble such proteins into larger structures is still primitive. Proteins are typically joined by reversible or non-specific linkages. We have designed a unique way to connect protein building blocks irreversibly and precisely, via spontaneous isopeptide bond formation. This involves modifying proteins with a short peptide tag (SpyTag) that is based upon remarkable chemistry used by pathogenic Gram-positive bacte",{"id":1015,"funder":7,"programme":8,"title":1016,"piName":14,"institution":1017,"country":66,"year":13,"amount":1018,"abstract":1019},"cordis-european-research-council-award-615703","EXtreme Tectonics and Rapid Erosion in Mountain Environments","EBERHARD KARLS UNIVERSITAET TUEBINGEN","€1,999,956","Tectonic plate corners are hotspots for high rates of continental deformation and erosion, and associated with human-relevant hazards including poorly understood earthquakes, destructive landslides, and extreme climate. A better understanding of continental deformation can mitigate these hazards. However, the coupling between climate and tectonic interactions at plate corners is a key unknown and the focus of this study. My recent work, published in international journals including Science and N",{"id":1021,"funder":7,"programme":8,"title":1022,"piName":14,"institution":1023,"country":60,"year":13,"amount":1024,"abstract":1025},"cordis-european-research-council-award-616417","Engineering Bio-inspired Materials for Biosensing and Regenerative Medicine","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€1,999,460","In Naturale CG I propose transformative bioengineering approaches that will overcome severe limitations in current materials in two main areas, namely 1) Biosensing and 2) Regenerative Medicine. A key focus is on understanding and engineering the biomaterial interface using innovative designs and state of the art materials characterisation methods. Firstly I aim to transform the way that we can currently detect disease through innovations in the design and development of nanomaterials-based bios",{"id":1027,"funder":7,"programme":8,"title":1028,"piName":14,"institution":1023,"country":60,"year":13,"amount":14,"abstract":1029},"cordis-european-research-council-award-617896","Systems Medical Diagnostics by In-vivo Ambient Mass Spectrometric Profiling of Tissue Lipidome","The objective of the proposal is the development of ambient mass spectrometric methods for the characterisation of mucosal metabolome and lipidome. While recent advent of ambient MS provided new means for in-situ and imaging analyses and led to the development of real-time, in-vivo MS characterisation of tissues, there are no methods available for minimally invasive testing of mucosal surfaces including the associated microflora. Human mucosa-associated microbiome (with special emphasis on the g",{"id":1031,"funder":7,"programme":8,"title":1032,"piName":14,"institution":863,"country":60,"year":13,"amount":1033,"abstract":1034},"cordis-european-research-council-award-616922","Communication Theoretical Foundations of Nervous System Towards BIO-inspired Nanonetworks and ICT-inspired Neuro-treatment","€1,757,039","“There’s Plenty of Room at the Bottom”, stated by Nobel laureate Richard Feynman, describes the possibility of manipulating individual atoms and molecules to realise nanomachines. Emerging nanoscale applications mandate enabling nanomachines to communicate and form nanonetworks to overcome the limitations of a single one. Thus, our aim is to find the answer to the profound question, i.e., “is the room down there sufficient for a communication network?” Thanks to natural evolution, the affirmativ",{"id":1036,"funder":7,"programme":8,"title":1037,"piName":14,"institution":1038,"country":39,"year":13,"amount":91,"abstract":1039},"cordis-european-research-council-award-617471","Genetics-driven targeted therapy of Hairy Cell Leukemia","UNIVERSITA DEGLI STUDI DI PERUGIA","Hairy Cell Leukemia (HCL),  a chronic B-cell neoplasm, is initially sensitive to chemotherapy with purine analogs, but ~40% of patients eventually relapses and becomes less responsive to these drugs. Furthermore, purine analogs may cause myelotoxicity, immune-suppression and severe opportunistic infections. Therefore, molecularly-targeted less toxic drugs are highly desirable in HCL. However, its low incidence and the initial efficacy of purine analogs has made HCL an orphan in the world of canc",{"id":1041,"funder":7,"programme":8,"title":1042,"piName":14,"institution":1038,"country":39,"year":13,"amount":1043,"abstract":1044},"cordis-european-research-council-award-612776","A geochemical clock to measure timescales of volcanic eruptions","€1,993,813","The eruption of volcanoes appears one of the most unpredictable phenomena on Earth. Yet the situation is rapidly changing. Quantification of the eruptive record constrains what is possible in a given volcanic system. Timing is the hardest part to quantify.The main process triggering an eruption is the refilling of a sub-volcanic magma chamber by a new magma coming from depth. This process results in magma mixing and provokes a time-dependent diffusion of chemical elements. Understanding the time",{"id":1046,"funder":7,"programme":8,"title":1047,"piName":14,"institution":1048,"country":154,"year":13,"amount":1049,"abstract":1050},"cordis-european-research-council-award-615307","Progress in quantum computing: Algorithms, communication, and applications","STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN","€1,453,700","Quantum computing combines computer science, physics and mathematics to fundamentally speed up computation using effects from quantum physics. Starting in the early 1980s with Feynman and Deutsch, and gaining momentum in the 1990s with the algorithms of Shor and Grover, this very interdisciplinary area has potentially far reaching consequences. While a large-scale quantum computer has not been built yet, experimenters are getting more optimistic: a recent prediction is that it will take another ",{"id":1052,"funder":7,"programme":8,"title":1053,"piName":14,"institution":1048,"country":154,"year":13,"amount":1054,"abstract":1055},"cordis-european-research-council-award-617199","ALERT - The Apertif-LOFAR Exploration of the Radio Transient Sky","€1,999,823","In our largely unchanging radio Universe, a highly dynamic component was recently discovered: flashes of bright radio emission that last only milliseconds but appear all over the sky. Some of these radio bursts can be traced to intermittently pulsating neutron stars. Other bursts however, apparently originate far outside our Galaxy. Due to great observational challenges, the evolution of the neutron stars is not understood, while more importantly, the nature of the extragalactic bursts remains a",{"id":1057,"funder":7,"programme":8,"title":1058,"piName":14,"institution":1059,"country":131,"year":13,"amount":1060,"abstract":1061},"cordis-european-research-council-award-615922","Black Carbon in the Atmosphere: Emissions, Aging and Cloud Interactions","PAUL SCHERRER INSTITUT","€1,992,015","Atmospheric aerosol particles have been shown to impact the earth's climate because they scatter and absorb solar radiation (direct effect) and because they can modify the microphysical properties of clouds by acting as cloud condensation nuclei or ice nuclei (indirect effects). Radiative forcing by anthropogenic aerosols remains poorly quantified, thus leading to considerable uncertainty in our understanding of the earth’s climate response to the radiative forcing by greenhouse gases. Black car",{"id":1063,"funder":7,"programme":8,"title":1064,"piName":14,"institution":1065,"country":131,"year":13,"amount":1066,"abstract":1067},"cordis-european-research-council-award-614552","TOR and Cellular Homeostasis","UNIVERSITE DE GENEVE","€1,991,686","The Target Of Rapamycin (TOR) proteins are ser\u002Fthr kinases conserved in Eukarya. They nucleate two distinct multiprotein complexes, named TORC1 and TORC2, which regulate many, widely varying, aspects of cell and organism physiology.  TOR inhibitors, such as rapamycin and derivatives, are used clinically to treat cancer, cardio-vasculature disease and to prevent organ rejection.We recently reported that both TORC1\u002F2 are wired in feedback loops, where their downstream cellular effectors are at the",{"id":1069,"funder":7,"programme":8,"title":1070,"piName":14,"institution":1065,"country":131,"year":13,"amount":1071,"abstract":1072},"cordis-european-research-council-award-614347","Optical dissection of cortical motor circuits","€1,997,671","The motor cortex plays a key role in learning and orchestrating fine voluntary movements, which dominate many aspects of our daily lives.Despite decades of research, considerable controversy remains over the functional organization of this forebrain area and its role in goal directed action. In this project we will combine cutting edge in vivo two-photon imaging, decoding methods and optogenetic manipulations to study different motor related circuits with single cell resolution. This approach wi",{"id":1074,"funder":7,"programme":8,"title":1075,"piName":14,"institution":1065,"country":131,"year":13,"amount":1076,"abstract":1077},"cordis-european-research-council-award-614847","Metabolic actions of brain leptin receptors signaling in type 1 diabetes","€1,999,500","An established dogma is that insulin is absolutely required for survival. This notion has been supported by the fact that the sole life-saving intervention available to the millions affected by type 1 diabetes mellitus (T1DM; an illness caused by pancreatic β-cell loss and hence insulin deficiency) is insulin therapy. This treatment however does not restore normal metabolic homeostasis. In fact, the life-expectancy and -quality of T1DM people is worse compared to normal subjects. In part, this i",{"id":1079,"funder":7,"programme":8,"title":1080,"piName":14,"institution":1081,"country":131,"year":13,"amount":14,"abstract":1082},"cordis-european-research-council-award-617508","Transforming Raw Data into Information through Virtualization","ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE","The unprecedented evolution of computing power, combined with the decreasing costs of computation and storage infrastructure, has revolutionized all scientific fields and enterprises; at the heart of this revolution is the ability to collect unprecedented amounts of data. Real progress, however, depends on how efficiently we can ‘extract value from chaos’, i.e., process the collected data and transform it into useful information. Unfortunately, despite the impressive growth of data management te",{"id":1084,"funder":7,"programme":8,"title":1085,"piName":14,"institution":1081,"country":131,"year":13,"amount":14,"abstract":1086},"cordis-european-research-council-award-616305","Water, Ions, Interfaces: Quantum effects, charge and cooperativity in water, aqueous solutions and interfaces","Sixty percent of the human body consists of water. Water provides the 3D-network for life’s constituents. In a cell there are many interfaces: the average distance between two molecules or a molecule and a membrane interfaces is ~1 nm. Water and the interfaces it interacts with are of paramount importance for biological processes. The structural, dynamic, and biological properties of water, aqueous systems and aqueous interfaces are essential in understanding the complexity of life, and our abil",{"id":1088,"funder":7,"programme":8,"title":1089,"piName":14,"institution":1090,"country":66,"year":13,"amount":1091,"abstract":1092},"cordis-european-research-council-award-615216","Variational Methods for Dynamic Inverse Problems in the Life Sciences","FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG","€966,400","This project will develop novel techniques for solving inverse problems in life sciences, in particular related to dynamic imaging. Major challenges in this area are efficient four- dimensional image reconstruction under low SNR conditions and further the quantification of image series as obtained from molecular imaging or life microscopy techniques. We will tackle both of them in a rather unified framework as inverse problems for time-dependent (systems of) partial differential equations.In the",{"id":1094,"funder":7,"programme":8,"title":1095,"piName":14,"institution":1090,"country":66,"year":13,"amount":1096,"abstract":1097},"cordis-european-research-council-award-616823","Attosecond physics at nanoscale metal tips - strong field physics in the near-field optics regime","€2,012,733","Electron dynamics in metals and nanostructures take place on attosecond timescales. Until today, these extremely fast processes are little understood let alone utilized. With NearFieldAtto, strong-field driven phenomena at nanoscale metal structures will be explored to elucidate collective electron dynamics and to induce optical-field-driven currents -- on attosecond timescales. We will investigate the near-field of a nanotip, resulting from the collective dynamics, both in amplitude and phase. ",{"id":1099,"funder":7,"programme":8,"title":1100,"piName":14,"institution":1101,"country":200,"year":13,"amount":1102,"abstract":1103},"cordis-european-research-council-award-616186","TRansItions and Turbulence Of complex Suspensions","KUNGLIGA TEKNISKA HOEGSKOLAN","€1,998,350","The aim of this project is to forge a physical understanding of the transitions and of the turbulent flow of semi-dilute\u002Fdense non-colloidal suspensions, for different particle features and suspending fluids.It is estimated that 10% of the world energy consumption is due to the transport and handling of granular materials of which particle suspensions are an important part. A deep understanding of the mechanisms underlying the flow of particle suspensions, the transition to turbulence and the tu",{"id":1105,"funder":7,"programme":8,"title":1106,"piName":14,"institution":1101,"country":200,"year":13,"amount":91,"abstract":1107},"cordis-european-research-council-award-615458","Highly Multiplexed Affinity Proteomics for Point of Care Diagnostics","The main objective is the development of highly multiplexed affinity proteomics tools for point of care diagnostics. Enabled by the world's largest resource of antibodies to human protein targets generated within the framework of the Human Protein Atlas program, the aim of this application is to develop new concepts in translational medical research to allow dramatic improvement in performance and accessibility of point of care tests in both high and low resource clinical settings in infectious ",{"id":1109,"funder":7,"programme":8,"title":1110,"piName":14,"institution":1101,"country":200,"year":13,"amount":1111,"abstract":1112},"cordis-european-research-council-award-616846","Terahertz microsystems - Enabling the large-scale exploitation of the terahertz gap","€1,727,189","This project envisions the wide-spread use of THz technology in various applications in our society, which is enabled by the proposed THz microsystems, providing an unprecedented way of creating highly-integrated, volume-manufacturable, cost and energy-efficient, reconfigurable and thus adaptive submillimeter-wave and THz systems. Advanced three-dimensional micromachining is used as the key enabling fabrication technology. In connection with the technology convergence of advancing microwave semi",{"id":1114,"funder":7,"programme":8,"title":1115,"piName":14,"institution":52,"country":53,"year":13,"amount":1116,"abstract":1117},"cordis-european-research-council-award-614964","Active Mechanisms of Cell Selection: From Cell Competition to Cell Fitness.","€1,968,062","The molecular mechanisms that mediate cell competition, cell fitness and cell selection is gaining interest. With innovative approaches, molecules and ground-breaking hypothesis, this field of research can help understand several biological processes such as development, cancer and tissue degeneration. The project has 3 clear and ambitious objectives: 1. We propose to identify all the key genes mediating cell competition and their molecular mechanisms. In order to reach this objective we will us",200,{"programme":8,"total":1120,"withPiName":1121,"firstYear":13,"lastYear":1122,"countryCount":1123,"perYear":1124,"topInstitutions":1165,"topCountries":1234},4499,349,2027,45,[1125,1127,1130,1133,1136,1139,1142,1145,1148,1151,1154,1157,1160,1163],{"year":13,"count":1126},303,{"year":1128,"count":1129},2015,335,{"year":1131,"count":1132},2016,322,{"year":1134,"count":1135},2017,327,{"year":1137,"count":1138},2018,403,{"year":1140,"count":1141},2019,300,{"year":1143,"count":1144},2020,277,{"year":1146,"count":1147},2021,321,{"year":1149,"count":1150},2022,364,{"year":1152,"count":1153},2023,359,{"year":1155,"count":1156},2024,366,{"year":1158,"count":1159},2025,375,{"year":1161,"count":1162},2026,416,{"year":1122,"count":1164},31,[1166,1169,1172,1175,1178,1181,1184,1186,1188,1191,1193,1196,1199,1201,1203,1206,1209,1212,1215,1218,1220,1223,1226,1229,1232],{"name":1167,"count":1168},"Centre National de la Recherche Scientifique CNRS",229,{"name":1170,"count":1171},"University of Oxford",89,{"name":1173,"count":1174},"Weizmann Institute of Science",78,{"name":1176,"count":1177},"University of Cambridge",77,{"name":1179,"count":1180},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",63,{"name":1182,"count":1183},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",55,{"name":1185,"count":1183},"Institut National de la Sante Et de la Recherche Medicale",{"name":1187,"count":1183},"Kobenhavns Universitet",{"name":1189,"count":1190},"Universiteit Utrecht",51,{"name":1192,"count":1190},"University College London",{"name":1194,"count":1195},"Tel Aviv University",49,{"name":1197,"count":1198},"The Hebrew University of Jerusalem",43,{"name":1200,"count":1198},"Universiteit Gent",{"name":1202,"count":1198},"Universiteit van Amsterdam",{"name":1204,"count":1205},"Ludwig-Maximilians-Universitaet Muenchen",42,{"name":1207,"count":1208},"Technische Universitaet Muenchen",41,{"name":1210,"count":1211},"Eidgenoessische Technische Hochschule Zuerich",40,{"name":1213,"count":1214},"Universitat Wien",39,{"name":1216,"count":1217},"Helsingin Yliopisto",38,{"name":1219,"count":1217},"Technische Universiteit Delft",{"name":1221,"count":1222},"Katholieke Universiteit Leuven",37,{"name":1224,"count":1225},"Universitetet I Oslo",36,{"name":1227,"count":1228},"École Polytechnique Fédérale de Lausanne",34,{"name":1230,"count":1231},"The University of Edinburgh",32,{"name":1233,"count":1164},"Lunds Universitet",[1235,1237,1239,1241,1243,1245,1247,1249,1250,1252,1254,1256,1258,1260,1262,1264,1266,1269,1271,1273,1275,1278,1280,1282,1285],{"name":66,"count":1236},810,{"name":60,"count":1238},559,{"name":46,"count":1240},490,{"name":154,"count":1242},428,{"name":84,"count":1244},315,{"name":39,"count":1246},267,{"name":263,"count":1248},219,{"name":131,"count":1118},{"name":200,"count":1251},170,{"name":27,"count":1253},166,{"name":235,"count":1255},146,{"name":257,"count":1257},127,{"name":441,"count":1259},94,{"name":583,"count":1261},85,{"name":12,"count":1263},82,{"name":53,"count":1265},68,{"name":1267,"count":1268},"GB",47,{"name":1270,"count":1225},"CZ",{"name":118,"count":1272},24,{"name":296,"count":1274},22,{"name":1276,"count":1277},"US",21,{"name":764,"count":1279},20,{"name":20,"count":1281},14,{"name":1283,"count":1284},"LU",13,{"name":1286,"count":1287},"EE",8]