[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-consolidator-grant-2015":3,"awarded-stats-erc-consolidator-grant":1101},{"awarded":4,"total":1100},[5,16,23,28,35,41,48,55,61,68,75,80,86,93,98,103,108,113,118,124,128,132,138,143,148,154,160,166,170,175,179,185,189,193,198,204,210,215,220,225,230,235,241,245,251,257,262,267,272,277,282,288,294,300,305,310,316,320,326,331,335,341,346,351,356,361,365,371,376,381,386,391,397,402,406,412,418,423,428,433,438,444,450,456,461,466,470,475,481,487,493,499,504,511,517,523,528,534,539,545,550,555,561,567,572,578,584,590,597,603,609,616,621,627,632,638,644,650,655,660,665,671,677,682,688,694,699,704,710,716,722,728,733,739,745,752,759,765,770,775,781,786,791,796,800,805,810,815,821,827,833,838,844,849,853,859,863,868,874,880,885,890,896,901,906,911,915,921,926,932,938,942,948,953,959,965,970,976,981,987,991,997,1003,1009,1015,1021,1026,1033,1038,1044,1049,1054,1060,1065,1071,1076,1082,1086,1091,1095],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-615653","European Research Council","ERC Consolidator Grant","Exploiting Synergistic Properties of Mesoionic Carbene Complexes: Teaching Rusty Metals Challenging Catalysis",null,"UNIVERSITAET BERN","CH",2015,"€2,111,111","The non-innocence of specific ligands in transition metal complexes is well-documented. For example, mesoionic carbenes engage in bond activation processes via reversible hydrogen capture. Such cooperativity between the metal center and the ligand flattens the potential energy surface of a catalytic reaction and hence rises the competence of the catalyst, thus entailing higher turnover numbers as well as the conversion of more challenging substrates. Likewise, such cooperativity is expected to e",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":20,"year":13,"amount":21,"abstract":22},"cordis-european-research-council-award-617670","Ionic dynamics and plasticity in developing neuronal networks","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","UK","€1,689,631","Ionic gradients are a fundamental feature of the nervous system and its development. They are established by the actions of ion pumps, transporters and channel proteins that reside in the membrane of cells. And maintaining these gradients is a prerequisite for generating fluxes of ions, which in turn drive cellular processes. Ion regulatory mechanisms often differ between cell types and changes in intracellular ion concentration have been implicated in multiple processes in the developing brain,",{"id":24,"funder":7,"programme":8,"title":25,"piName":10,"institution":26,"country":20,"year":13,"amount":10,"abstract":27},"cordis-european-research-council-award-616393","Roads and the politics of thought: Ethnographic approaches to infrastructure development in South Asia","SCHOOL OF ORIENTAL AND AFRICAN STUDIES ROYAL CHARTER","New roads are being constructed at unprecedented rates in certain parts of the world. The proposed research will ask: Why? To what end? Who benefits? What ideas lie in the foundations of this new infrastructure? Roads are presented as solutions to poverty, ‘development’ and economic growth? Are they? In what ways? What else might roads do? As cheap oil dwindles and questions of climate change remain, why are so many international institutions cultivating new roads?The project will provide the fi",{"id":29,"funder":7,"programme":8,"title":30,"piName":10,"institution":31,"country":32,"year":13,"amount":33,"abstract":34},"cordis-european-research-council-award-615220","Dynamics of the RNAi-mediated antiviral immunity","INSTITUT PASTEUR","FR","€1,442,600","RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that is induced by double-stranded RNA (dsRNA). Double-stranded RNA is commonly generated during viral replication and is considered to be a molecular pattern associated with viral infection. Our previous work demonstrated that viral infections in the fruit fly Drosophila melanogaster are countered by an antiviral RNAi response: the small interfering RNA (siRNA) pathway is the major antiviral defence mechanism in ",{"id":36,"funder":7,"programme":8,"title":37,"piName":10,"institution":38,"country":32,"year":13,"amount":39,"abstract":40},"cordis-european-research-council-award-616986","Regulation of inflammasome activity through NLRP3 ubiquitination level","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","€1,933,724","The innate immunity constitutes an efficient barrier by rapidly detecting pathogens and tissue damages through pattern recognition receptors including NLRP3. On the other hand, inappropriate NLRP3 activation causes deleterious inflammation and contributes to various conditions including atherosclerosis, diabetes, gout and Alzheimer's diseases. Therefore NLRP3 requires tight regulation that remains poorly characterized. Activated NLRP3 assembles a multimeric inflammasome complex serving as activa",{"id":42,"funder":7,"programme":8,"title":43,"piName":10,"institution":44,"country":45,"year":13,"amount":46,"abstract":47},"cordis-european-research-council-award-617509","The evolutionary ecology of cognition across a heterogeneous landscape","UNIVERSITY COLLEGE CORK -  NATIONAL UNIVERSITY OF IRELAND, CORK","IE","€1,993,189","Why do individuals vary in their cognitive abilities? This proposal takes the disciplines of cognition and evolutionary biology into a natural setting to answer this question by investigating a variety of proximate causes and population-level consequences of individual variation in cognitive ability. It represents the first large-scale integrative study of cognitive ability on any wild population. State of the art observational (remote sensing and automated self-administration trials of learning",{"id":49,"funder":7,"programme":8,"title":50,"piName":10,"institution":51,"country":52,"year":13,"amount":53,"abstract":54},"cordis-european-research-council-award-615253","Ontogenetic transcriptome evolution in tetrapods","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","DE","€1,998,632","A central goal in evolutionary biology is to understand the molecular changes responsible for phenotypic differences between species, in particular those that have arisen among mammals. Phenotypic evolution is thought to be largely founded on developmental gene regulatory changes, which determine species-specific tissue morphologies and thus lay the foundation for their typical physiological properties. We recently performed the first cross-mammalian transcriptome comparisons for adult organs, p",{"id":56,"funder":7,"programme":8,"title":57,"piName":10,"institution":58,"country":59,"year":13,"amount":10,"abstract":60},"cordis-european-research-council-award-616480","Multiscale regulation of epithelial tension","FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA","ES","Throughout development and adult life, the growth and remodelling of living tissues is determined by a complex interplay between chemical and physical cues. Among such physical cues, mechanical tension is emerging as central regulator of cellular fate and function. To explain tension regulation, current research emphasizes molecular mechanisms at an ever increasing level of detail. How these local mechanisms are integrated to give rise to global patterns of tissue tension is unknown, however. Th",{"id":62,"funder":7,"programme":8,"title":63,"piName":10,"institution":64,"country":65,"year":13,"amount":66,"abstract":67},"cordis-european-research-council-award-617393","Next Generation Causal Analysis: Inspired by the Induction of Biological Pathways from Cytometry Data","PANEPISTIMIO KRITIS","EL","€1,724,000","Discovering the causal mechanisms of a complex system of interacting components is necessary in order to control it. Computational Causal Discovery (CD) is a field that offers the potential to discover causal relations under certain conditions from observational data alone or with a limited number of interventions\u002Fmanipulations.An important, challenging biological problem that may take decades of experimental work is the induction of biological cellular pathways; pathways are informal causal mod",{"id":69,"funder":7,"programme":8,"title":70,"piName":10,"institution":71,"country":72,"year":13,"amount":73,"abstract":74},"cordis-european-research-council-award-615755","Cavity quantum phonon dynamics","AALTO KORKEAKOULUSAATIO SR","FI","€2,004,283","Large bodies usually follow the classical equations of motion. Deviations from this can be calledmacroscopic quantum behavior. These phenomena have been experimentally verified with cavity QuantumElectro Dynamics (QED), trapped ions, and superconducting Josephson junction systems. Recently, evidencewas obtained that also moving objects can display such behavior. These objects are micromechanicalresonators (MR), which can measure tens of microns in size and are hence quite macroscopic. The degree",{"id":76,"funder":7,"programme":8,"title":77,"piName":10,"institution":38,"country":32,"year":13,"amount":78,"abstract":79},"cordis-european-research-council-award-616917","mTOR pathophysiology in rare human diseases","€1,998,000","The mammalian Target Of Rapamycin (mTOR) is a master regulator of growth. mTOR is a protein kinase that exists in two distinct complexes in the cell and transduces virtually all anabolic signals from the environment: nutrients, such as glucose and amino acids, growth factor peptides, such as insulin and insulin like growth factors, oxygen, mitochondrial metabolites, energy status. mTOR is required to sustain cell responses to nutrient availability including cell growth, proliferation, macromolec",{"id":81,"funder":7,"programme":8,"title":82,"piName":10,"institution":83,"country":52,"year":13,"amount":84,"abstract":85},"cordis-european-research-council-award-647158","Quantifying Flexibility in Communication Networks","TECHNISCHE UNIVERSITAET MUENCHEN","€1,931,250","Communication networks have emerged to become the basic infrastructure for all areas of our society with application areas ranging from social media to industrial production and healthcare. New requirements include the need for dynamic changes of the required resources, for example, to react to social events or to shifts of demands. Existing networks and, in particular, the Internet cannot meet those requirements mainly due to their ossification and hence limitation in resource allocation, i.e.,",{"id":87,"funder":7,"programme":8,"title":88,"piName":10,"institution":89,"country":90,"year":13,"amount":91,"abstract":92},"cordis-european-research-council-award-648551","Graphene Coated Nanoparticles and Nanograins","AARHUS UNIVERSITET","DK","€1,996,147","In a truly cross-disciplinary research project encompassing surface science, optics, nano-science, astrophysics and chemistry we will synthesize a novel family of high quality mono-layer graphene coated nanoparticles and graphene nanograins with new chemical and optical properties and investigate their catalytic activity, chemical stability and optical characteristics to gauge their relevance for and applicability in industrial catalysis, solar cells, and interstellar chemistry. This will be acc",{"id":94,"funder":7,"programme":8,"title":95,"piName":10,"institution":89,"country":90,"year":13,"amount":96,"abstract":97},"cordis-european-research-council-award-647544","Automated Program Analysis for Advanced Web Applications","€1,977,382","Web applications that execute in the user's web browser constitute a substantial part of modern software. JavaScript is the main programming language of the web, although alternatives are emerging, in particular, TypeScript and Dart. Despite the advances in design of languages and libraries, it is difficult to prevent errors when programming such web applications. Although the basic principles of software verification have been known for decades and researchers have developed an abundance of tec",{"id":99,"funder":7,"programme":8,"title":100,"piName":10,"institution":38,"country":32,"year":13,"amount":101,"abstract":102},"cordis-european-research-council-award-648768","Neural regulation of immunity","€2,000,000","Survival of living organisms depends on their capacity to develop defence mechanisms against environmental challenges that cause tissue damage and infections. These protective functions involve the nervous system and the immune system, two systems traditionally considered as independent. However anatomical and cellular bases for bidirectional interactions between them have been established and a new paradigm on a regulatory role of the nervous system on immune functions is emerging. Pain is one ",{"id":104,"funder":7,"programme":8,"title":105,"piName":10,"institution":38,"country":32,"year":13,"amount":106,"abstract":107},"cordis-european-research-council-award-647687","Molecular and structural pharmacology of adiponectin receptor: towards innovative treatments of obesity-related diseases.","€1,989,518","The human kind is witnessing an escalation of obesity-related health problems such as cardiovascular diseases and type 2 diabetes. A recent groundbreaking study revealed adiponectin receptors (ADIPOR) as key targets for treating such obesity-related diseases. Indeed, the modulation of this integral membrane protein by small molecules agonists ameliorates diabetes and prolongs lifespan of genetically obese rodent model. Despite these exciting results and the importance of ADIPOR in human physiolo",{"id":109,"funder":7,"programme":8,"title":110,"piName":10,"institution":38,"country":32,"year":13,"amount":111,"abstract":112},"cordis-european-research-council-award-647466","Ependymal cell Development: New insight into neurological diseases","€1,999,484","Understanding how billions of neurons are born, migrate and integrate into functional circuits has proved useful in elucidating the pathomechanisms of many neurodevelopmental disorders. Multiciliated ependymal cells have attracted less interest and their development is still enigmatic. However, their strategic location at the interface between brain ventricles and parenchyma and their unique morphology and functions strongly suggest that defects in the generation of these cells may be associated",{"id":114,"funder":7,"programme":8,"title":115,"piName":10,"institution":38,"country":32,"year":13,"amount":116,"abstract":117},"cordis-european-research-council-award-648030","Structure and Dynamics of Low-Complexity Regions in Proteins: The Huntingtin Case","€1,999,844","Proteins hosting regions highly enriched in one or few amino acids, the so-called Low-Complexity Regions (LCR), are very common in eukaryotes and play crucial roles in biology. Homorepeats, a subfamily of LCR that present stretches of the same amino acid, perform very specialized functions facilitated by the localized enrichment of the same physicochemical property. In contrast, numerous severe pathologies have been associated to abnormally long repetitions. Despite the relevance of homorepeats,",{"id":119,"funder":7,"programme":8,"title":120,"piName":10,"institution":121,"country":32,"year":13,"amount":122,"abstract":123},"cordis-european-research-council-award-649117","Building up a brain: understanding how neural stem cell fate and regulation controls nervous tissue architecture","SORBONNE UNIVERSITE","€1,929,713","The brain is an extraordinary complex assembly of neuronal and glial cells that underpins cognitive functions. How adequate numbers of these cells are generated by neural stem cells in embryonic and early postnatal development and how they distribute and interconnect within brain tissue is still debated. In particular, the potentialities of individual neural stem cells, their potential heterogeneity and the mechanisms regulating their function are still poorly characterized in situ; likewise, th",{"id":125,"funder":7,"programme":8,"title":126,"piName":10,"institution":38,"country":32,"year":13,"amount":101,"abstract":127},"cordis-european-research-council-award-647000","Air pollution and noise exposure related to personal transport behaviour: short-term and longer-term effects on health","To support policies at the European and national levels, MobiliSense aims to explore the effects of air pollution and noise exposure related to personal transport habits on respiratory and cardiovascular health. Building on methods from Epidemiology, Geography, and Transport sciences, the objectives of MobiliSense are to quantify the contribution of personal transport to the air pollution and noise exposure of individuals; to compare the air pollution and noise exposure in the different transpor",{"id":129,"funder":7,"programme":8,"title":130,"piName":10,"institution":83,"country":52,"year":13,"amount":101,"abstract":131},"cordis-european-research-council-award-649323","3D Reloaded: Novel Algorithms for 3D Shape Inference and Analysis","Despite their amazing success, we believe that computer vision algorithms have only scratched the surface of what can be done in terms of modeling and understanding our world from images. We believe that novel image analysis techniques will be a major enabler and driving force behind next-generation technologies, enhancing everyday life and opening up radically new possibilities. And we believe that the key to achieving this is to develop algorithms for reconstructing and analyzing the 3D struct",{"id":133,"funder":7,"programme":8,"title":134,"piName":10,"institution":135,"country":52,"year":13,"amount":136,"abstract":137},"cordis-european-research-council-award-648420","Understanding evolutionary abiotic stress-network plasticity as foundation for new biotechnological strategies","HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH","€1,996,750","Abiotic stresses, such as drought or salt stress, affect plant growth and threaten the capacity to feed a growing world population. Understanding and altering how plants deal with stress will be critical for society’s adaptation to a changed climate. I propose a novel systems-biology based approach to identify biotechnological targets based on comparison of interaction and signalling networks of evolutionary related species that show differential abiotic stress tolerance. Similar to most crops, ",{"id":139,"funder":7,"programme":8,"title":140,"piName":10,"institution":83,"country":52,"year":13,"amount":141,"abstract":142},"cordis-european-research-council-award-647695","Attosecond Electron Dynamics in MOlecular Systems","€1,999,375","Advanced insight into ever smaller structures of matter and their ever faster dynamics hold promise for pushing the frontiers of many fields in science and technology. Time-domain investigations of ultrafast microscopic processes are most successfully carried out by pump\u002Fprobe experiments. Intense waveform-controlled few-cycle near-infrared laser pulses combined with isolated sub-femtosecond XUV (extreme UV) pulses have made possible direct access to electron motion on the atomic scale. These to",{"id":144,"funder":7,"programme":8,"title":145,"piName":10,"institution":83,"country":52,"year":13,"amount":146,"abstract":147},"cordis-european-research-council-award-647168","Cell biology of myelin wrapping, plasticity and turnover","€1,872,500","The myelin sheath is a plasma membrane extension that is laid down in regular spaced segments along axons of the nervous system. In the central nervous system it is formed by oligodendrocytes that spirally wrap their plasma membrane around axons to generate a highly abundant, tightly packed stack of membranes with unique structural properties. Previously, myelin has been regarded as an inert and purely insulating membrane, but it now appears that myelin is metabolically active, providing metabol",{"id":149,"funder":7,"programme":8,"title":150,"piName":10,"institution":151,"country":32,"year":13,"amount":152,"abstract":153},"cordis-european-research-council-award-648032","Distributed Biological Algorithms","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€1,894,947","This project proposes a new application for computational reasoning. More specifically, the purpose of this interdisciplinary project is to demonstrate the usefulness of an algorithmic perspective in studies of complex biological systems. We focus on the domain of collective behavior, and demonstrate the benefits of using techniques from the field of theoretical distributed computing in order to establish algorithmic insights regarding the behavior of biological ensembles. The project includes t",{"id":155,"funder":7,"programme":8,"title":156,"piName":10,"institution":157,"country":158,"year":13,"amount":10,"abstract":159},"cordis-european-research-council-award-648274","RENal prOgenItoRs as tools to understand kidney pathophysiology and treat kidney disorders","UNIVERSITA DEGLI STUDI DI FIRENZE","IT","Kidney disorders represent a major global health issue and new tools are needed to expand disease modeling and therapeutic options. The identification of renal progenitors (RPC) opens a wide range of possibilities to support progress in several fields of nephrology. Indeed, RPC have become a key player in the pathogenesis of kidney disorders, and their study is increasing knowledge about the mechanisms of kidney response to injury. In this project we propose new lineage tracing models to identif",{"id":161,"funder":7,"programme":8,"title":162,"piName":10,"institution":163,"country":45,"year":13,"amount":164,"abstract":165},"cordis-european-research-council-award-647004","3D Printing of Cell Laden Biomimetic Materials and Biomolecules for Joint Regeneration","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","€1,999,700","Osteoarthritis (OA) is a serious disease of the joints affecting nearly 10% of the population worldwide. Realising an efficacious therapeutic solution for treating OA remains one of the greatest challenges in the field of orthopaedic medicine. This proposal envisions a future where 3D bioprinting systems located in hospitals will provide ‘off-the-shelf’, patient-specific biological implants to treat diseases such as OA. To realise this vision, this project will use 3D bioprinting to generate ana",{"id":167,"funder":7,"programme":8,"title":168,"piName":10,"institution":163,"country":45,"year":13,"amount":10,"abstract":169},"cordis-european-research-council-award-646883","SHARECITY: Assessing the practice and sustainability potential of city-based food sharing economies","With planetary urbanization fast approaching there is growing clarity regarding the unsustainability of cities, not least with respect to food consumption. Sharing, including food sharing, is increasingly being identified as one transformative mechanism for sustainable cities: reducing consumption; conserving resources, preventing waste and providing new forms of socio-economic relations. However, such claims currently rest on thin conceptual and empirical foundations. SHARECITY will identify an",{"id":171,"funder":7,"programme":8,"title":172,"piName":10,"institution":163,"country":45,"year":13,"amount":173,"abstract":174},"cordis-european-research-council-award-647719","Towards Artificial Enzymes: Bio-inspired Oxidations in Photoactive Metal-Organic Frameworks","€1,979,366","Metal-organic frameworks (MOFs) are key compounds related to energy storage and conversion, as their unprecedented surface areas make them promising materials for gas storage and catalysis purposes. We believe that their modular construction principles allow the replication of key features of natural enzymes thus demonstrating how cavity size, shape, charge and functional group availability influence the performances in catalytic reactions. This proposal addresses the question of how such novel,",{"id":176,"funder":7,"programme":8,"title":177,"piName":10,"institution":163,"country":45,"year":13,"amount":10,"abstract":178},"cordis-european-research-council-award-647356","Loop amplitudes in quantum field theory","The traditional formulation of relativistic quantum theory is ill-equipped to handle the range of difficult computations needed to describe particle collisions at the Large Hadron Collider (LHC) within a suitable time frame. Yet, recent work shows that probability amplitudes in quantum gauge field theories, such as those describing the Standard Model and its extensions, take surprisingly simple forms. The simplicity indicates deep structure in gauge theory that has already led to dramatic comput",{"id":180,"funder":7,"programme":8,"title":181,"piName":10,"institution":182,"country":183,"year":13,"amount":10,"abstract":184},"cordis-european-research-council-award-648141","Synthetic platforms for ad libitum remodelling of yeast central metabolism","TECHNISCHE UNIVERSITEIT DELFT","NL","Replacement of petrochemistry by bio-based processes is key to sustainable development and requires microbes equipped with novel-to-nature capabilities. The efficiency of such engineered microbes strongly depends on their native metabolic networks. However, aeons of evolution have optimized these networks for fitness in nature rather than for industrial performance. As a result, central metabolic networks are complex and encoded by mosaic microbial genomes in which genes, irrespective of their f",{"id":186,"funder":7,"programme":8,"title":187,"piName":10,"institution":182,"country":183,"year":13,"amount":101,"abstract":188},"cordis-european-research-council-award-648433","In control of exciton and charge dynamics in molecular crystals","The aim of the work proposed here is to achieve control over charge and excited state dynamics in organic crystalline materials and in this way to come to solid state materials with explicit built-in functionality. The charge and excited state dynamics do not only depend on the properties of individual molecules but are to a large extent determined by the interactions between multiple molecules. By careful engineering of the properties of individual molecules and of the way they aggregate in the",{"id":190,"funder":7,"programme":8,"title":191,"piName":10,"institution":182,"country":183,"year":13,"amount":10,"abstract":192},"cordis-european-research-council-award-648580","Optical nanoscopy at 1 nm resolution: far-field fluorescence control at cryogenic temperatures","Optical nanoscopy is a powerful technique used in biology to study subcellular structures and function via specifically targeted fluorescent labels. Localization microscopy in particular offers a much better resolution (~10-50 nm) than conventional microscopy (~250 nm) while being relatively undemanding on the experimental setup and the subsequent image analysis.  The next revolution in imaging to 1 nm isotropic resolution in 3D must realize a big increase in the number of collected photons from",{"id":194,"funder":7,"programme":8,"title":195,"piName":10,"institution":196,"country":32,"year":13,"amount":10,"abstract":197},"cordis-european-research-council-award-647383","Stars: dynamical Processes driving tidal Interactions, Rotation and Evolution","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","The rotational dynamics of stars strongly impacts their evolution and those of their planetary and galactic environment. Space helio- and asteroseismology recently allowed an observational revolution in this domain. They revealed, e.g., that the core of the Sun is close to a uniform rotation while those of subgiant and red giant stars slow down drastically during their evolution. These important results demonstrate that powerful dynamical mechanisms (internal waves, magnetic fields, turbulence) ",{"id":199,"funder":7,"programme":8,"title":200,"piName":10,"institution":201,"country":20,"year":13,"amount":202,"abstract":203},"cordis-european-research-council-award-648661","Ice Nucleating Particles in the Marine Atmosphere","UNIVERSITY OF LEEDS","€2,681,881","The formation of ice in clouds is fundamentally important to life on our planet since clouds play a key role in climate and the hydrological cycle. Despite the significance of ice formation, our quantitative understanding of sources, properties, mode of action and transport of Ice-Nucleating Particles (INP) is poor. In order to improve our representation of clouds in models we need to understand the ice-nucleating ability of all major aerosol types, including those from the world’s oceans.Despit",{"id":205,"funder":7,"programme":8,"title":206,"piName":10,"institution":207,"country":208,"year":13,"amount":101,"abstract":209},"cordis-european-research-council-award-647047","Cancer treatment during pregnancy: from fetal safety to maternal efficacy","KATHOLIEKE UNIVERSITEIT LEUVEN","BE","The evolution in drug regulation of the last 50 years has left pregnant women and their fetuses orphaned. This is particularly problematic for cancer during pregnancy, which raises a difficult and conflicting medical ethical decision process and which has recently become increasingly frequent. In 2012 we published the first prospective study indicating that antenatal exposure to cancer treatment can overall be considered safe. Building on this proof of concept, the current proposal wants to take",{"id":211,"funder":7,"programme":8,"title":212,"piName":10,"institution":213,"country":59,"year":13,"amount":10,"abstract":214},"cordis-european-research-council-award-648831","Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients","FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPE FELIPE","Research on anticancer therapies has provided little progress towards improved survival rates for patients with metastatic disease. The intrinsic advantages of polymer conjugates can be optimised to rationally design targeted combination therapies, concept I pioneered that allows enhanced therapeutic efficiency. Early clinical trials involving conjugates showed activity in chemotherapy refractory patients and reduced drug-related toxicity. However, there is a growing concern on patient variabili",{"id":216,"funder":7,"programme":8,"title":217,"piName":10,"institution":218,"country":20,"year":13,"amount":10,"abstract":219},"cordis-european-research-council-award-646876","Defining hormonal cross-talk and the role of mutations in estrogen receptor positive breast cancer","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","Estrogen Receptor (ER) is the driving transcription factor in ~75% of all breast cancers. ER antagonists are routinely used for treatment, but significant variability exists in clinical response. We are interested in explaining this heterogeneity and exploiting the mechanistic insight. We have recently identified important, but previously uncharacterised cross-talk between ER and the progesterone receptor (PR) and androgen receptor (AR) pathways, both of which are commonly expressed in ER+ tumou",{"id":221,"funder":7,"programme":8,"title":222,"piName":10,"institution":223,"country":20,"year":13,"amount":10,"abstract":224},"cordis-european-research-council-award-646769","Externally Tuneable Separations for Membrane Reactors","UNIVERSITY OF BATH","I will develop an all new type of reactor for pharmaceutical and chemical process applications – the ‘tuneable membrane reactor’. These contain ground-breaking conducting polymer composite membranes that will allow in-situ tuning of the molecular selectivity for both neutral and charged species through them. This is revolutionary: current state-of-the-art membranes can be electrically tuned for charged species only. The project is timely, developing a new technology that can give the EU a compet",{"id":226,"funder":7,"programme":8,"title":227,"piName":10,"institution":151,"country":32,"year":13,"amount":228,"abstract":229},"cordis-european-research-council-award-648236","Electron Quantum optics in quantum Hall edge channels","€1,997,878","Quantum effects have been studied on photon propagation in the context of quantum optics since the second half of the last century. In particular, using single photon emitters, fundamental tests of quantum mechanics were explored by manipulating single to few photons in Hanbury-Brown and Twiss and Hong Ou Mandel experiments.  In nanophysics, there is a growing interest to translate these concepts of quantum optics to electrons propagating in nanostructures. Single electron emitters have been rea",{"id":231,"funder":7,"programme":8,"title":232,"piName":10,"institution":233,"country":59,"year":13,"amount":101,"abstract":234},"cordis-european-research-council-award-647359","Global dynamics of topoisomerase-induced DNA breaks","FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III","DNA topoisomerases are conserved nuclear enzymes that regulate DNA topology by transiently cleaving and resealing the DNA molecule, fulfilling a fundamental role in virtually every aspect of chromosome metabolism. Nevertheless, erroneous or abortive topoisomerase activity can result in persistent DNA strand breaks with the enzyme covalently attached to 3’ or 5’ DNA ends by a phosphotyrosyl bond, an anomalous structure that can compromise cell survival and\u002For genome integrity with the consequent ",{"id":236,"funder":7,"programme":8,"title":237,"piName":10,"institution":238,"country":59,"year":13,"amount":239,"abstract":240},"cordis-european-research-council-award-648901","Finding a needle in a haystack: efficient identification of high performing organic energy materials","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","€2,423,894","Following promising early breakthroughs, progress in the development of high-performance multicomponent organic energy materials has stalled due to a bottleneck in device optimization. FOREMAT will develop a breakthrough technology to overcome this bottleneck by shifting from fabrication-intense to measurement-intense assessment methods, enabling rapid multi-parameter optimization of novel systems. Our goal is to deliver organic material systems with a step-change in performance, bringing them c",{"id":242,"funder":7,"programme":8,"title":243,"piName":10,"institution":238,"country":59,"year":13,"amount":10,"abstract":244},"cordis-european-research-council-award-647012","Thalamic control of Neuroplasticity","The cerebral cortex is organized into highly specialized sensory areas. Thus, it is fundamental to understand how these areas acquire and maintain their identity and functional organization. Challenging normal brain development and forcing the brain to the limits of plasticity, offers us the possibility to shed light on these issues. Accordingly, we shall use prenatal sensory deprivation as a model to understand the mechanisms underlying early neuroplasticity, events that could influence the nat",{"id":246,"funder":7,"programme":8,"title":247,"piName":10,"institution":248,"country":52,"year":13,"amount":249,"abstract":250},"cordis-european-research-council-award-648701","Analysis, Verification, and Synthesis for Infinite-State Systems","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€1,834,975","The central objective of this project is to investigate key algorithmic verification questions concerning two fundamental mathematical structures used to model and analyse infinite-state systems, namely discrete linear dynamical systems and counter automata, in both ordinary and parametric form. Motivated especially by applications to software model checking (more specifically the termination of linear loops and predicate abstraction computations), as well as parametric real-time reasoning and t",{"id":252,"funder":7,"programme":8,"title":253,"piName":10,"institution":254,"country":72,"year":13,"amount":255,"abstract":256},"cordis-european-research-council-award-649053","Bio-Imaging of Zoonotic and Emerging Bunyaviruses","HELSINGIN YLIOPISTO","€1,998,375","We aim to understand host cell entry of enveloped viruses at molecular level. A crucial step in this process is when the viral membrane fuses with the cell membrane. Similarly to cell–cell fusion, this step is mediated by fusion proteins (classes I–III). Several medically important viruses, notably dengue and many bunyaviruses, harbour a class II fusion protein. Class II fusion protein structures have been solved in pre- and post-fusion conformation and in some cases different factors promoting ",{"id":258,"funder":7,"programme":8,"title":259,"piName":10,"institution":19,"country":20,"year":13,"amount":260,"abstract":261},"cordis-european-research-council-award-647586","Social Evolution and Social Engineering of bacterial Infections","€1,954,633","Micro-organisms were believed until recently to live independent, unicellular lives but are now understood to rely on complex systems of social behaviours for survival. In pathogenic bacteria, cooperation and communication between cells leads to increased virulence and the understanding of how these behaviours evolve is of fundamental importance to the future of human health. Almost nothing is known, however, about social behaviours of bacteria infecting human hosts, and research on social behav",{"id":263,"funder":7,"programme":8,"title":264,"piName":10,"institution":19,"country":20,"year":13,"amount":265,"abstract":266},"cordis-european-research-council-award-647152","New Approaches to the Identification of Macroeconomic Models","€1,312,383","Macroeconomic data are largely non-experimental. Thus, causal inference in macroeconomics is largely based on assumptions about what aspects of the variation in the data are exogenous. This presents two major challenges, which this research addresses directly. First, few such assumptions are generally accepted. Second, conditional on any set of assumptions, identification of causal effects is often weak because there is little relevant variation in the data. To tackle these challenges, I propose",{"id":268,"funder":7,"programme":8,"title":269,"piName":10,"institution":19,"country":20,"year":13,"amount":270,"abstract":271},"cordis-european-research-council-award-647278","Molecular analysis of the Hedgehog signal transduction complex in the primary cilium","€1,727,456","The unexpected connection between the primary cilium and cell-to-cell signalling is one of the most exciting discoveries in cell and developmental biology in the last decade. In particular, the Hedgehog (Hh) pathway relies on the primary cilium to fulfil its fundamental functions in orchestrating vertebrate development. This microtubule-based antenna, up to 5 µm long, protrudes from the plasma membrane of almost every human cell and is the essential compartment for the entire Hh signalling casca",{"id":273,"funder":7,"programme":8,"title":274,"piName":10,"institution":238,"country":59,"year":13,"amount":275,"abstract":276},"cordis-european-research-council-award-648518","Single-Use paPER-based fuel CELLs","€1,920,738","The advances in paper microfluidics taking place in recent years show that the new generation of paper-based devices will be able to overcome the limitations of traditional lateral flow tests and offer more accurate and specific information. However, the quantification of paper devices signals by colorimetry, electrochemistry or fluorescence entails the use of sensors and electronic components that require energy to function. Up to now, this has been solved by the use of battery-powered bulky re",{"id":278,"funder":7,"programme":8,"title":279,"piName":10,"institution":280,"country":183,"year":13,"amount":10,"abstract":281},"cordis-european-research-council-award-649087","New constraints on the Amazonian carbon balance from airborne observations of the stable isotopes of CO2","WAGENINGEN UNIVERSITY","Severe droughts in Amazonia in 2005 and 2010 caused widespread loss of carbon from the terrestrial biosphere. This loss, almost twice the annual fossil fuel CO2 emissions in the EU, suggests a large sensitivity of the Amazonian carbon balance to a predicted more intense drought regime in the next decades. This is a dangerous inference though, as there is no scientific consensus on the most basic metrics of Amazonian carbon exchange: the gross primary production (GPP) and its response to moisture",{"id":283,"funder":7,"programme":8,"title":284,"piName":10,"institution":285,"country":20,"year":13,"amount":286,"abstract":287},"cordis-european-research-council-award-648011","Interfacing spin waves with superconducting quantum circuits for single magnon creation and detection","UNIVERSITY OF GLASGOW","€1,996,337","The proposed project will experimentally interface ferromagnets with superconducting quantum circuits to study dynamics within the magnet. To this end, magnonic elements made up by thin, structured magnetic films will be strongly coupled to the qubit. Superconducting qubits are ideal detectors due to their quantum limited back-action on the measured object and energy resolution.Spectroscopy and coherence measurements on the hybrid system will be made in order to address fundamental aspects such ",{"id":289,"funder":7,"programme":8,"title":290,"piName":10,"institution":291,"country":158,"year":13,"amount":292,"abstract":293},"cordis-european-research-council-award-646990","Mechanobiology of nuclear import of transcription factors modeled within a bioengineered stem cell niche.","POLITECNICO DI MILANO","€1,903,330","Many therapeutic applications of stem cells require accurate control of their differentiation. To this purpose there is a major ongoing effort in the development of advanced culture substrates to be used as “synthetic niches” for the cells, mimicking the native ones. The goal of this project is to use a synthetic niche cell culture model to test my revolutionary hypothesis that in stem cell differentiation, nuclear import of gene-regulating transcription factors is controlled by the stretch of t",{"id":295,"funder":7,"programme":8,"title":296,"piName":10,"institution":297,"country":59,"year":13,"amount":298,"abstract":299},"cordis-european-research-council-award-647514","HISTORICAL ROOTS OF CONFLICT AND DEVELOPMENT: FROM PREHISTORY TO THE COLONIZATION EXPERIENCE","UNIVERSIDAD POMPEU FABRA","€1,699,664","I plan to study the effect of history on conflict and economic development with two historical microscopes.Following the lead of the new institutional economics, part of the literature argues that institutions cause differences in productivity and factor endowments which, in turn, explain economic development. An alternative view assumes that human capital shapes institutional changes and, therefore, institutions are endogenous. In the first part of the project, which is the core of the research",{"id":301,"funder":7,"programme":8,"title":302,"piName":10,"institution":297,"country":59,"year":13,"amount":303,"abstract":304},"cordis-european-research-council-award-648610","Justice and the Family: An Analysis of the Normative Significance of Procreation and Parenthood in a Just Society","€811,750","This project examines the normative significance of procreation and parenthood for theories of justice. Important questions of justice about the family arise once we acknowledge and keep in view that procreation and parenthood are both integral to the existence of any society (and therefore, a just society), and that they involve substantial benefits and burdens for parents, children, and society at large. Yet existing theories of justice generally neglect these questions by assuming that the pr",{"id":306,"funder":7,"programme":8,"title":307,"piName":10,"institution":297,"country":59,"year":13,"amount":308,"abstract":309},"cordis-european-research-council-award-648398","Debt and Persistence of Financial Shocks","€1,308,676","In 2007 the US and Europe were overwhelmed by a banking crisis, which was followed by a severe economic recession. Historical studies show that financial crises are followed by periods of substantially stronger contraction of aggregate output and employment than non-financial recessions. Those studies also point out that the best predictor of financial crises is an ex-ante strong credit boom which, after the beginning of the crisis, followed by negative overall credit growth. Lastly, financial c",{"id":311,"funder":7,"programme":8,"title":312,"piName":10,"institution":313,"country":32,"year":13,"amount":314,"abstract":315},"cordis-european-research-council-award-645865","Automated Security Proofs of Cryptographic Protocols: Privacy, Untrusted Platforms and Applications to E-voting Protocols","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","€1,903,500","The rise of the Internet and the ubiquity of electronic devices has deeply changed our way of life. Many face to face and paper transactions have nowadays digital counterparts: home banking, e- commerce, e-voting, etc. The security of such transactions is ensured by the means of cryptographic protocols. While historically the main goals of protocols were to ensure confidentiality and authentication the situation has changed. The ability of people to stay connected constantly combined with ill-co",{"id":317,"funder":7,"programme":8,"title":318,"piName":10,"institution":313,"country":32,"year":13,"amount":10,"abstract":319},"cordis-european-research-council-award-647134","Guaranteed fully adaptive algorithms with tailored inexact solvers for complex porous media flows","Efficient use of computational resources with a reliable outcome is a definite target in numerical simulations of partial differential equations (PDEs). Although this has been an important subject of numerical analysis and scientific computing for decades, still, surprisingly, often more than 90% of the CPU time in numerical simulations is literally wasted and the accuracy of the final outcome is not guaranteed. The reason is that addressing this complex issue rigorously is extremely challenging",{"id":321,"funder":7,"programme":8,"title":322,"piName":10,"institution":323,"country":52,"year":13,"amount":324,"abstract":325},"cordis-european-research-council-award-646717","Atom-Tunneling in Chemistry","UNIVERSITY OF STUTTGART","€1,986,750","Quantum mechanical tunneling of atoms is emerging as an ubiquitous phenomenon in chemistry. Every chemical reaction that includes a hydrogen transfer can be expected to be influenced by tunneling at room temperature. While simulations can monitor tunneling directly, experimental approaches can only detect the consequences. Theoretical investigations, as planned in TUNNELCHEM, have to keep up in order to aid the rational interpretation. We build on significant algorithmic breakthroughs recently a",{"id":327,"funder":7,"programme":8,"title":328,"piName":10,"institution":151,"country":32,"year":13,"amount":329,"abstract":330},"cordis-european-research-council-award-648558","Escaping from the Franck-Condon region : a theoretical approach to describe molecular STructural ReorganIzation for reversible EnerGy and information storage at the Excited State","€1,202,500","STRIGES is a theoretical project aimed at developing new computational approaches and descriptors essentially rooted on Density Functional Theory enabling to design new single molecule architectures able to undergo to significant light induced electronic and structural reorganization.In this respect the present project concerns beside fundamental goals, such as the development of new theoretical approaches for the description of photochemical and photophysical processes in molecular systems,  th",{"id":332,"funder":7,"programme":8,"title":333,"piName":10,"institution":151,"country":32,"year":13,"amount":10,"abstract":334},"cordis-european-research-council-award-648963","Are HPV vaccines ‘evolution-proof’? Multilevel evolutionary ecology of human oncoviruses","There is a threat that evolutionary responses can render vaccines ineffective, as illustrated by the emergence of the increasingly virulent Marek Disease Virus strains in poultry following vaccination campaigns. Assessing the ‘evolution-proof’ nature of vaccines targeting human viruses is challenging because it requires an understanding of the epidemiology, the within-host ecology and the evolutionary potential of the virus. To date, most investigations into the spread of vaccine-resistant strai",{"id":336,"funder":7,"programme":8,"title":337,"piName":10,"institution":338,"country":158,"year":13,"amount":339,"abstract":340},"cordis-european-research-council-award-647390","Exploring Matter with Precision Charm and Beauty Production Measurements in Heavy Nuclei Collisions at LHCb","UNIVERSITA DEGLI STUDI DI CAGLIARI","€1,849,957","Collisions of ultra relativistic nuclei are a tool to reach huge energy densities and to form a new state of matter called Quark-Gluon Plasma (QGP), where quarks and gluons can move freely. A number of experiments have studied the possible formation of QGP, but the behaviour of heavy particles such as charm (c) and beauty (b) quarks when they traverse this medium is largely unknown and is the most powerful tool to prove the creation of the QGP and to characterise it. I will perform novel measure",{"id":342,"funder":7,"programme":8,"title":343,"piName":10,"institution":151,"country":32,"year":13,"amount":344,"abstract":345},"cordis-european-research-council-award-646788","Versatility of scaffold complexes in vivo to control synaptic plasticity","€1,964,199","Receptors and associated scaffolds, together called receptosome, are relatively stable structures, but exchange of individual adaptor proteins can occur on a short time scale and in a highly regulated manner, which provides fine-tuning, speed, and specificity to the receptor signaling. Therefore, understanding how receptor function is affected by the composition and dynamics of complexes is an essential biological concern that will offer the opportunity to target exclusively the therapeutically ",{"id":347,"funder":7,"programme":8,"title":348,"piName":10,"institution":151,"country":32,"year":13,"amount":349,"abstract":350},"cordis-european-research-council-award-647257","IMMUNOBIOLOGY OF LYMPHOID STROMAL CELLS","€2,547,762","In 1984, Nossal wrote ‘‘A readership consisting of primarily anatomists has every right to question the favorite sport of research workers in cell immunology. This is to take a lymphoid tissue and totally destroy its beautiful and elaborately designed architecture to obtain simple cell suspension of lymphocytes, which are then asked to do more or less all the jobs of the original anatomic masterpiece’’. Growing evidence that lymph node (LN) stromal cells control the motility, activation and surv",{"id":352,"funder":7,"programme":8,"title":353,"piName":10,"institution":151,"country":32,"year":13,"amount":354,"abstract":355},"cordis-european-research-council-award-647353","Representations of quantum affine algebras and applications","€1,182,000","Quantum affine algebras are important examples of Drinfeld-Jimbo quantum groups. They can be defined as quantizationsof affine Kac-Moody algebras or as affinizations of finite type quantum groups (Drinfeld Theorem).The representation theory of quantum affine algebras is very rich. It has been studied intensively during the past twenty fiveyears from different point of views, in particular in connections with various fields in mathematics and in physics, such asgeometry (geometric representation ",{"id":357,"funder":7,"programme":8,"title":358,"piName":10,"institution":359,"country":32,"year":13,"amount":101,"abstract":360},"cordis-european-research-council-award-647938","Multimodal glycoconjugates: a molecular Lego approach for antitumoral immunotherapy","UNIVERSITE GRENOBLE ALPES","Despite significant progress in cancer therapy, current treatments are still controversial due to intolerable side effects. Targeted immunotherapy has recently emerged as an ideal alternative to improve treatment modalities for cancers patients. However, very limited approaches are available today and major issues remain to be addressed. The ERC grant offers a unique opportunity to propose a new paradigm for treating cancer. Through a ground-breaking interdisciplinary program, at the crossroad o",{"id":362,"funder":7,"programme":8,"title":363,"piName":10,"institution":151,"country":32,"year":13,"amount":101,"abstract":364},"cordis-european-research-council-award-647344","Chromatin function in DNA Double Strand breaks repair: Prime, repair and restore DSB Inducible via AsiSI","Among the types of damage, DNA Double Strands Breaks (DSBs) are the most deleterious, as illustrated by the variety of human diseases associated with DSB repair defects. Repair of DSB into the chromatin context raises several questions that we aim to address in this proposal. Firstly, it is likely that the chromatin environment where a break occurs influences the choice of repair pathway. Since the different DSB repair mechanisms can lead to different scar on the genome, further studies are requ",{"id":366,"funder":7,"programme":8,"title":367,"piName":10,"institution":368,"country":32,"year":13,"amount":369,"abstract":370},"cordis-european-research-council-award-646894","Tracing ancient microbial cells embedded in silica","INSTITUT DE PHYSIQUE DU GLOBE DE PARIS","€1,999,250","Reconstructing the nature and habitat of early life is a difficult task that strongly depends on the study of rare microfossils in the ancient rock record. The preservation of such organic structures critically depends on rapid entombment in a mineral matrix. Throughout most of Earth’s history the oceans were silica-supersaturated, leading to precipitation of opal deposits that incorporated superbly preserved microbial cells. As we trace this record of life back in deep time, however, three impo",{"id":372,"funder":7,"programme":8,"title":373,"piName":10,"institution":151,"country":32,"year":13,"amount":374,"abstract":375},"cordis-european-research-council-award-647618","Chromatin dynamics during DNA replication","€1,984,677","Chromatin assembly is a fundamental cellular process necessary for the maintenance of genome integrity and transcriptional programs. Understanding the effect of DNA replication on histone protein dynamics is also a prerequisite for understanding the role of chromatin in epigenetic inheritance. Epigenetic phenomena are thought to influence cellular differentiation and cancer formation, as well as the impact of environmental factors on early development and later predispositions to disease. While ",{"id":377,"funder":7,"programme":8,"title":378,"piName":10,"institution":151,"country":32,"year":13,"amount":379,"abstract":380},"cordis-european-research-council-award-647384","Plant movements and mechano-perception: from biophysics to biomimetics","€1,933,996","How to transport fluids, move solids or perceive mechanical signals without the equivalent of pumps, muscles or nerves? This ongoing challenge, which is relevant from microfluidics to robotics, has long been solved by plants. In this project, I wish to gather my cross-disciplinary background in plant mechanics, soft matter physics and granular materials to address some of the fundamental mechanisms used by plants to perceive mechanical stimuli and generate motion. The project focuses on three ma",{"id":382,"funder":7,"programme":8,"title":383,"piName":10,"institution":151,"country":32,"year":13,"amount":384,"abstract":385},"cordis-european-research-council-award-647003","Metabolic Networks that Link Longevity to Reproduction in Response to Nutrition","€1,941,499","In most western countries, life expectancy is increasing by 3 months a year. As the average age of the population increases, so too does the prevalence of age-related diseases such as cancer, cardiovascular and metabolic diseases, and neurodegenerative disorders. An essential component of ageing research is to understand the biological mechanisms that contribute to the ageing process at the cellular and molecular levels. This has major implications not only for the treatment of age-associated di",{"id":387,"funder":7,"programme":8,"title":388,"piName":10,"institution":151,"country":32,"year":13,"amount":389,"abstract":390},"cordis-european-research-council-award-648974","Structure of paramagnetic integral membrane metalloproteins by MAS-NMR","€2,499,375","Integral membrane metalloproteins are involved in the transport and homeostasis of metal ions, as well as in key redox reactions that have a tremendous impact on many fields within life sciences, environment, energy, and industry. Most of our understanding of fine details of biochemical processes derives from atomic or molecular structures obtained by diffraction methods on single crystal samples. However, in the case of integral membrane systems, single crystals large enough for X-ray diffracti",{"id":392,"funder":7,"programme":8,"title":393,"piName":10,"institution":394,"country":32,"year":13,"amount":395,"abstract":396},"cordis-european-research-council-award-648779","Magnetic approaches for Tissue Mechanics and Engineering","UNIVERSITE PARIS CITE","€1,589,000","While magnetic nanomaterials are increasingly used as clinical agents for imaging and therapy, their use as a tool for tissue engineering opens up challenging perspectives that have rarely been explored. Lying at the interface between biophysics and nanomedicine, and based on magnetic techniques, the proposed project aims to magnetically design functional tissues and to explore the tissular fate of nanomaterials. Magnetic nanoparticles will be safely introduced into therapeutic cells, thus allow",{"id":398,"funder":7,"programme":8,"title":399,"piName":10,"institution":400,"country":20,"year":13,"amount":101,"abstract":401},"cordis-european-research-council-award-648879","Complexity and dynamics of nucleic acids modifications in vivo","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","Development of any organism starts with a totipotent cell (zygote). Through series of cell divisions and differentiation processes this cell will eventually give rise to the whole organism containing hundreds of specialised cell. While the cells at the onset of development have the capacity to generate all cell types (ie are toti-or pluripotent), this developmental capacity is progressively lost as the cells undertake cell fate decisions. At the molecular level, the memory of these events is lai",{"id":403,"funder":7,"programme":8,"title":404,"piName":10,"institution":151,"country":32,"year":13,"amount":10,"abstract":405},"cordis-european-research-council-award-649081","Monsoons of Asia caused Greenhouse to Icehouse Cooling","Unraveling the cause for Cenozoic global climate cooling is one of the most important unresolved questions challenging the Earth and Environmental sciences community today. Increased erosion and weathering of the uplifted Tibetan Plateau and Himalayas, is advocated as the primary cause for the enigmatic pCO2 drawdown, that led to global cooling 50 to 34 Myrs ago from the warm ice-free Greenhouse world to the bi-polar Icehouse conditions still prevailing today. Asian Monsoons are genetically link",{"id":407,"funder":7,"programme":8,"title":408,"piName":10,"institution":409,"country":20,"year":13,"amount":410,"abstract":411},"cordis-european-research-council-award-648228","Regulation of antibody responses by B cell mechanical activity","UNIVERSITY COLLEGE LONDON","€1,999,386","The production of antibodies against pathogens is an effective mechanism of protection against a wide range of infections. However, some pathogens evade antibody responses by rapidly changing their composition. Designing vaccines that elicit antibody responses against invariant parts of the pathogen is a rational strategy to combat existing and emerging pathogens. Production of antibodies is initiated by binding of B cell receptors (BCRs) to foreign antigens presented on the surfaces of antigen ",{"id":413,"funder":7,"programme":8,"title":414,"piName":10,"institution":415,"country":32,"year":13,"amount":416,"abstract":417},"cordis-european-research-council-award-648528","Ultrabright Turn-on Fluorescent Organic Nanoparticles for Amplified Molecular Sensing in Living Cells","UNIVERSITE DE STRASBOURG","€1,999,750","Existing fluorescent molecular probes, due to limited brightness, do not allow imaging individual biomolecules directly in living cells, whereas bright fluorescent nanoparticles are unable to respond to single molecular stimuli and their inorganic core is not biodegradable. The aim of BrightSens is to develop ultrabright fluorescent organic nanoparticles (FONs) capable to convert single molecular stimuli into collective turn-on response of >100 encapsulated dyes, and to apply them in amplified m",{"id":419,"funder":7,"programme":8,"title":420,"piName":10,"institution":151,"country":32,"year":13,"amount":421,"abstract":422},"cordis-european-research-council-award-647100","Magnetic, electric-field and light induced control of spin-polarized supercurrents: fundamentals for an offbeat electronics","€1,997,729","This project aims at establishing the basis for high-temperature superconducting spintronics. The innovative idea is to use spin-polarized superconducting pairs -instead of normal electrons- to convey and manipulate information, taking advantage of the coherent transport inherent to superconductivity. To further increase the potential of this approach, we intend to create multiple control knobs: magnetic field, the classical one in spintronics, as well as the knobs customary in conventional elec",{"id":424,"funder":7,"programme":8,"title":425,"piName":10,"institution":151,"country":32,"year":13,"amount":426,"abstract":427},"cordis-european-research-council-award-648132","Automata in Number Theory","€1,438,745","Finite automata are fundamental objects in Computer Science, of great importance on one hand for theoretical aspects (formal language theory, decidability, complexity) and on the other for practical applications (parsing). In number theory, finite automata are mainly used as simple devices for generating sequences of symbols over a finite set (e.g., digital representations of real numbers), and  for recognizing some sets of integers or more generally of finitely generated abelian groups or monoi",{"id":429,"funder":7,"programme":8,"title":430,"piName":10,"institution":151,"country":32,"year":13,"amount":431,"abstract":432},"cordis-european-research-council-award-647275","Programming in vitro evolution using molecular fitness functions","€2,141,379","Natural enzymes are awesome catalysts, in terms of their catalytic efficiency, selectivity, control mechanisms, etc. Revamped as laboratory or industrial tools, they have allowed more than a few breakthroughs, such as PCR, next generation sequencing or green chemistry. The next revolution will be brought by a new generation of extensively modified “enzymatic” catalysts working in non-natural environments, possibly build from non-natural chemistries and targeting an unlimited range of non-natural",{"id":434,"funder":7,"programme":8,"title":435,"piName":10,"institution":151,"country":32,"year":13,"amount":436,"abstract":437},"cordis-european-research-council-award-647784","Catching in action a novel bacterial chaperone for respiratory complexes","€1,999,956","Cellular respiration provides energy to power essential processes of life.  Respiratory complexes are macromolecular batteries coupling electron flow through a wire of metal clusters and cofactors with proton transfer across the inner membrane of mitochondria and bacteria. Waste products of these cellular factories are reactive oxygen species causing ageing and diseases. Assembly and maturation mechanisms of respiratory complexes remain enigmatic because of their membrane location, multisubunit ",{"id":439,"funder":7,"programme":8,"title":440,"piName":10,"institution":441,"country":32,"year":13,"amount":442,"abstract":443},"cordis-european-research-council-award-648377","Mixing interfaces as reactive hotspots of porous media flows: theoretical upscaling, experimental imaging and field scale validation","UNIVERSITE DE RENNES","€1,998,747","In porous media, mixing interfaces such as contaminant plume fringes or boundaries between water bodies create highly reactive localized hotspots of chemical and microbiological activity, whether in engineered or natural systems. These reactive fronts are characterized by high concentration gradients, complex flow dynamics, variable water saturation, fluctuating redox conditions and multifunctional biological communities. The spatial and temporal variability of velocity gradients is expected to ",{"id":445,"funder":7,"programme":8,"title":446,"piName":10,"institution":447,"country":59,"year":13,"amount":448,"abstract":449},"cordis-european-research-council-award-647857","Sensing soil processes for improved crop nitrogen bioavailability","NEIKER-INSTITUTO VASCO DE INVESTIGACION Y DESARROLLO AGRARIO SA","€1,978,475","Food production is predicated on the application of nitrogen fertilisers, which can contribute significantly to the production of greenhouse gasses and eutrophication of agroecosystems. The use of nitrogen fertilisers must, therefore, be optimised.The recent development of transparent soils in my group gives great scope to unravel the processes involved in the reactive transport of nutrients in soil and their interaction with the soil biota. My team will combine principles of optics, chemical en",{"id":451,"funder":7,"programme":8,"title":452,"piName":10,"institution":453,"country":32,"year":13,"amount":454,"abstract":455},"cordis-european-research-council-award-647973","Unravelling the Genomic Targets of Drugs Using High-Throughput Sequencing","INSTITUT CURIE","€1,999,900","This proposal is centred on the development of small molecule probes derived from DNA damaging agents to identify their genomic targets using a novel unbiased approach. Although, several genotoxic drugs have been used for decades to treat cancers, the exact mechanisms by which they operate are not fully understood. It is established that these compounds interfere with the processes of transcription and replication, thereby promoting genomic instability and cell death. However, there is as yet no",{"id":457,"funder":7,"programme":8,"title":458,"piName":10,"institution":151,"country":32,"year":13,"amount":459,"abstract":460},"cordis-european-research-council-award-647917","Ultra-Cold Nano-Mechanics: from Classical to Quantum Complexity","€1,990,574","Nano-electro-mechanical devices (NEMS) are extremely small objects that can be actuated and detected by electric means. They are in the first place transducers that can be used as probes for forces down to the molecular level. Top-down fabricated NEMS using conventional microelectronics techniques are simple devices that intimately link mechanical and electrical degrees of freedom. As such, they can be viewed as model systems from basic (linear) harmonic motion up to complex nonlinear dynamics.T",{"id":462,"funder":7,"programme":8,"title":463,"piName":10,"institution":151,"country":32,"year":13,"amount":464,"abstract":465},"cordis-european-research-council-award-647342","Low power consumption silicon optoelectronics based on strain and refractive index engineering","€1,999,300","The POPSTAR project aims at building a new class of silicon optoelectronic devices based on nonlinear optical effects for the development of high speed multiple wavelength photonic circuits in the near-IR wavelength range for data communication applications including optical interconnects and high performance computing systems. Three major cornerstones will be developed: (i) a 40Gbit\u002Fs optical modulators based on Pockels effect with energy consumption and swing voltage lower than 1fJ\u002Fbit and 1V,",{"id":467,"funder":7,"programme":8,"title":468,"piName":10,"institution":151,"country":32,"year":13,"amount":10,"abstract":469},"cordis-european-research-council-award-648001","Role of Epithelial Apoptotic Force in Morphogenesis","Contrary to previous beliefs, recent studies have suggested that apoptotic cells play an important dynamic role during morphogenesis. Nonetheless, the mechanisms whereby dying cells drive tissue shape modification remain elusive.  Using the Drosophila developing leg as a model system to study apoptosis-dependent epithelium folding, we have recently shown that apoptotic cells produce a pulling force through the unexpected maintenance of their adherens junctions that serves as an anchor to an apic",{"id":471,"funder":7,"programme":8,"title":472,"piName":10,"institution":359,"country":32,"year":13,"amount":473,"abstract":474},"cordis-european-research-council-award-647018","Wave turbulence: beyond weak turbulence","€1,991,611","Wave turbulence and fluid turbulence belong to the same class of turbulent states made of a large number of nonlinearly coupled degrees of freedom driven far from equilibrium. The Weak Turbulence Theory is a statistical theory of low amplitude turbulent waves. The predicted phenomenology (energy cascade) is very similar to that of fluid turbulence, which badly lacks such a statistical theory. Weak Turbulence is thus a promising mathematical framework for turbulence in general. It is observed in ",{"id":476,"funder":7,"programme":8,"title":477,"piName":10,"institution":478,"country":479,"year":13,"amount":101,"abstract":480},"cordis-european-research-council-award-647714","Controlling Cardiomyocyte Dyadic Structure","UNIVERSITETET I OSLO","NO","Contraction and relaxation of cardiac myocytes, and thus the whole heart, are critically dependent on dyads. These functional junctions between t-tubules, which are invaginations of the surface membrane, and the sarcoplasmic reticulum allow efficient control of calcium release into the cytosol, and also its removal. Dyads are formed gradually during development and break down during disease. However, the precise nature of dyadic structure is unclear, even in healthy adult cardiac myocytes, as ar",{"id":482,"funder":7,"programme":8,"title":483,"piName":10,"institution":484,"country":59,"year":13,"amount":485,"abstract":486},"cordis-european-research-council-award-648319","Hybrid Materials for Artificial Photosynthesis","Fundacion IMDEA Energia","€2,506,738","HyMAP aims to develop a new generation of multifunctional hybrid photocatalysts and solar photoreactor which would allow the exploitation of at least the 1 % of the sunlight energy for the CO2 photoreduction using water as electron donor. This will imply a CO2 conversion in the range of 12 to 35 Ton\u002Fy•ha, depending on product distribution, which represents at least a 20-fold improvement over the state of the art. To achieve this goal, I propose an interdisciplinary research program through which",{"id":488,"funder":7,"programme":8,"title":489,"piName":10,"institution":490,"country":52,"year":13,"amount":491,"abstract":492},"cordis-european-research-council-award-648295","Surface-grafted metallofullerene molecular magnets with controllable alignment of magnetic moments","LEIBNIZ INSTITUT FUR FESTKORPER UND WERKSTOFFORSCHUNG DRESDEN EV","€1,912,181","The molecules retaining their magnetization in the absence of magnetic field are known as single molecule magnets (SMMs). Important problems to be solved on the way to the applications of SMMs in molecular spintronics is their deposition on surfaces and addressing their spins on the single molecular level. In this project we will address these problems by designing SMMs based on endohedral metallofullerenes (EMFs) derivatized with anchoring groups. SMM behaviour recently discovered for DySc2N@C8",{"id":494,"funder":7,"programme":8,"title":495,"piName":10,"institution":496,"country":32,"year":13,"amount":497,"abstract":498},"cordis-european-research-council-award-647067","Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine","ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS","€1,999,396","Rupture of Aortic Aneurysms (AA), which kills more than 30 000 persons every year in Europe and the USA, is a complex phenomenon that occurs when the wall stress exceeds the local strength of the aorta due to degraded properties of the tissue. The state of the art in AA biomechanics and mechanobiology reveals that major scientific challenges still have to be addressed to permit patient-specific computational predictions of AA rupture and enable localized repair of the structure with targeted pha",{"id":500,"funder":7,"programme":8,"title":501,"piName":10,"institution":201,"country":20,"year":13,"amount":502,"abstract":503},"cordis-european-research-council-award-648375","In-situ produced nanoparticles for enhanced oil recovery","€1,958,733","The era of finding “easy oil” is coming to an end, and future supply will become more reliant on fossil fuels produced from enhanced oil recovery (EOR) process. Many EoR methods have been used, including mechanical, chemical, thermal and biological approaches, but there are still 50~70% of the original oil trapped in reservoir rocks after the primary and secondary recovery. NanoEOR, i.e, injecting nanoparticles (NPs) together with flooding fluids, is an emerging field. However all proposed appli",{"id":505,"funder":7,"programme":8,"title":506,"piName":10,"institution":507,"country":508,"year":13,"amount":509,"abstract":510},"cordis-european-research-council-award-646597","Matter and strong-field gravity: New frontiers in Einstein’s theory","INSTITUTO SUPERIOR TECNICO","PT","€1,588,817","Gravity is the weakest but the most intriguing fundamental interaction in the Universe. In the last decades a formidable intellectual effort has shown that the full-fledged geometric nature of gravity offers much more than a beautiful description and understanding of all stellar and galactic. In the quest for the ultimate theory of gravity, new and spectacular connections between high-energy physics, astrophysics, cosmology and theoretical physics have emerged. Triggered by breakthroughs at the ",{"id":512,"funder":7,"programme":8,"title":513,"piName":10,"institution":514,"country":20,"year":13,"amount":515,"abstract":516},"cordis-european-research-council-award-647839","Mapping gravitational waves from collisions of black holes","CARDIFF UNIVERSITY","€1,998,009","Breakthroughs in numerical relativity in 2005 gave us unprecedented access to the strong-field regime of general relativity, making possible solutions of the full nonlinear Einstein equations for the merger of two black holes. Numerical relativity is also crucial to study fundamental physics with gravitational-wave (GW) observations: numerical solutions allow us to construct models that will be essential to extract physical information from observations in data from Advanced LIGO and Virgo, whic",{"id":518,"funder":7,"programme":8,"title":519,"piName":10,"institution":520,"country":45,"year":13,"amount":521,"abstract":522},"cordis-european-research-council-award-647783","Metabolomics based biomarkers of dietary intake- new tools for nutrition research","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","€1,995,548","In todays advanced technological world, we can track the exact movement of individuals, analyse their genetic makeup and predict predisposition to certain diseases. However, we are unable to accurately assess an individual’s dietary intake. This is without a doubt one of the main stumbling blocks in assessing the link between diet and disease\u002Fhealth. The present proposal (A-DIET) will address this issue with the overarching objective to develop novel strategies for assessment of dietary intake.U",{"id":524,"funder":7,"programme":8,"title":525,"piName":10,"institution":254,"country":72,"year":13,"amount":526,"abstract":527},"cordis-european-research-council-award-647355","Novel etiology of autoimmune disorders: the role of acquired somatic mutations in lymphoid cells","€2,047,337","Molecular pathogenesis of most immune-mediated disorders, such as of autoimmune diseases, is poorly understood. These common maladies carry a heavy burden both on patients and on society. Current therapy is non-targeted and results in significant short- and long-term adverse effects.Large granular lymphocyte (LGL) leukemia is characterized by expansion of cytotoxic T- or NK-cells and represents an intriguing clinical continuum between a neoplastic and an autoimmune disorder. Patients suffer from",{"id":529,"funder":7,"programme":8,"title":530,"piName":10,"institution":531,"country":20,"year":13,"amount":532,"abstract":533},"cordis-european-research-council-award-648680","Dark Matter and the Early Universe in the LHC Era","KING'S COLLEGE LONDON","€1,947,665","The discovery of a Higgs like particle in its first science run shows that we are truly in the LHC era and when collisions resume we will learn more about the physics of the TeV scale.  There are two main areas at the interface of particle physics and cosmology that the LHC will shed light on - If dark matter is a thermal relic then we naturally expect new particle physics close to this TeV energy range.  The LHC will also help us learn about the nature of the electroweak sector and its behaviou",{"id":535,"funder":7,"programme":8,"title":536,"piName":10,"institution":218,"country":20,"year":13,"amount":537,"abstract":538},"cordis-european-research-council-award-647144","Understanding and Designing Novel NanoPores","€1,936,431","Translocation of ions and molecules is ubiquitous in biology and technology. Despite the tremendous amount of technical development, biological systems are still much more sophisticated in exerting exquisite control over active and passive translocation through nanopores in membranes than their existing synthetic mimics. This proposal aims to build novel designer nanopores that can match naturally evolved systems. For this we have to control all three stages of translocation: 1) diffusion and en",{"id":540,"funder":7,"programme":8,"title":541,"piName":10,"institution":542,"country":52,"year":13,"amount":543,"abstract":544},"cordis-european-research-council-award-646657","Understanding the neural mechanisms of multisensory perception based on computational principles","UNIVERSITAET BIELEFELD","€1,909,441","The brain’s multisensory faculty provides considerable benefits for perception, as the adaptive weighting of multiple inputs increases perceptual reliability and flexibility. However, failure of this process results in an impoverished percept, and links to perceptual deficits that occur along our life span and in disorders such as Autism. While the brain efficiently handles multiple sensory inputs, we still have a limited understanding of the underlying neural mechanisms. To advance our knowledg",{"id":546,"funder":7,"programme":8,"title":547,"piName":10,"institution":548,"country":72,"year":13,"amount":10,"abstract":549},"cordis-european-research-council-award-646857","Emulation of subgrid-scale aerosol-cloud interactions in climate models: towards a realistic representation of aerosol indirect effect","ILMATIETEEN LAITOS","I propose to develop an innovative interdisciplinary model framework to refine the estimate of aerosol indirect effect (i.e. influence of atmospheric aerosol particles on cloud properties), which remains the single largest uncertainty in the current drivers of climate change. A major reason for this uncertainty is that current climate models are unable to resolve the spatial scales for aerosol-cloud interactions. We will resolve this scale problem by using statistical emulation to build computat",{"id":551,"funder":7,"programme":8,"title":552,"piName":10,"institution":490,"country":52,"year":13,"amount":553,"abstract":554},"cordis-european-research-council-award-647276","Electronic Order, Magnetism, and Unconventional Superconductivity probed in Real-Space","€2,747,025","The interplay of electronic order with antiferromagnetism and superconductivity has recently emerged as a vital question for rationalizing the physics of all classes of unconventional superconductors. The electronic order is rarely sufficiently long-range correlated to render it susceptible for diffraction techniques. Instead, a local probe is usually required to detect it experimentally. It is clear, however, that such a probe must provide sensitivity at the same time to electronic order, super",{"id":556,"funder":7,"programme":8,"title":557,"piName":10,"institution":558,"country":52,"year":13,"amount":559,"abstract":560},"cordis-european-research-council-award-648166","Phon(t)on-induced phase transitions","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","€1,486,973","One of our dreams for the future is to control and manipulate complex materials and devices at will. This progress would revolutionize technology and influence many aspects of our everyday life.  A promising direction is the control of material properties by electromagnetic radiation leading to photo-induced phase transitions. An example of such a transition is the reported dynamically induced  superconductivity via a laser pulse.  Whereas the theoretical description of the coupling of fermions ",{"id":562,"funder":7,"programme":8,"title":563,"piName":10,"institution":564,"country":52,"year":13,"amount":565,"abstract":566},"cordis-european-research-council-award-648898","Decoding the epigenetic signature of memory function in health and disease","DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV","€1,729,125","The emerging field of neuroepigenetics investigates processes such as histone-acetylation in the context ofneuronal plasticity, memory function and brain diseases. My group has significantly contributed to this novelresearch field. It is however fair to say that the role of “epigenetics” in memory function is still met withsome skepticism in the neurosciences, which is in part due to the fact that many of the current studies havebeen describing phenomena and mechanistic data to explain how epige",{"id":568,"funder":7,"programme":8,"title":569,"piName":10,"institution":531,"country":20,"year":13,"amount":570,"abstract":571},"cordis-european-research-council-award-648837","REACH: Risk, Resilience, Ethnicity and AdolesCent Mental Health","€1,999,776","The overarching aim of REACH is to examine groundbreaking questions on the developmental origins of psychosis in migrant and minority ethnic populations using a highly innovative accelerated cohort study of adolescents, to be conducted in south London (UK). It has been known for over 50 years that the incidence of psychotic disorders is high in many migrant and minority ethnic groups across many countries. Our seminal study (AESOP) on this, for example, found that incidence rates were 3 to 6 tim",{"id":573,"funder":7,"programme":8,"title":574,"piName":10,"institution":575,"country":20,"year":13,"amount":576,"abstract":577},"cordis-european-research-council-award-648050","The physics of three dimensional chromosome and protein organisation within the cell","THE UNIVERSITY OF EDINBURGH","€1,499,236","Understanding the fundamental mechanisms behind the functioning of cells and their interior has long been a biology-only enterprise. This view has radically changed in the last decade or so, culminating in the invention of a whole new field, named 'cell physics', which uses the tools of physics to gain a more quantitative and deeper understanding of the inner working of a cell. The aim of my research fits broadly in this new field, although the scale of the computational studies which I plan are",{"id":579,"funder":7,"programme":8,"title":580,"piName":10,"institution":581,"country":183,"year":13,"amount":582,"abstract":583},"cordis-european-research-council-award-646734","Translating Hybrid Imaging for Interventions:  Intra-operative Guidance and Evaluation using 2D and 3D Interventional X-ray Scintigraphy Imaging","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","€1,999,000","I propose to research, build and evaluate Interventional X-ray and Scintigraphy Imaging (IXSI). This will provide for the first time real-time, multimodality imaging during medical interventions by combining live x-ray and live nuclear imaging simultaneously from an identical viewpoint. The hybrid x-ray\u002Fnuclear imaging device will enable surgeons and interventional radiologists to exploit the power of molecular imaging in the operating theatre and intervention room through i) live guidance using",{"id":585,"funder":7,"programme":8,"title":586,"piName":10,"institution":587,"country":158,"year":13,"amount":588,"abstract":589},"cordis-european-research-council-award-647782","Psychology and Economic Behavior: Theory, Tests and Applications","UNIVERSITA COMMERCIALE LUIGI BOCCONI","€1,431,650","This proposal purports to develop psychologically founded models of economic decision making, test these models, and use them to shed light on several economic phenomena. The proposal builds on the psychology of selective attention. In particular, decision makers more easily retrieve from memory (precisely defined) representative events when making an inference, and they attach disproportionate attention and weighting to (precisely defined) salient choice options when making a choice. These idea",{"id":591,"funder":7,"programme":8,"title":592,"piName":10,"institution":593,"country":594,"year":13,"amount":595,"abstract":596},"cordis-european-research-council-award-647077","A new class of microtubules in the spindle exerting forces on kinetochores","RUDER BOSKOVIC INSTITUTE","HR","€2,150,000","At the onset of division the cell forms a spindle, a micro-machine made of microtubules, which divide the chromosomes by pulling on kinetochores, protein complexes on the chromosome. The central question in the field is how accurate chromosome segregation results from the interactions between kinetochores, microtubules and the associated proteins. According to the current paradigm, the forces on kinetochores are produced by k-fibers, bundles of microtubules extending between the spindle pole and",{"id":598,"funder":7,"programme":8,"title":599,"piName":10,"institution":600,"country":32,"year":13,"amount":601,"abstract":602},"cordis-european-research-council-award-646592","A Multiscale and Multimodal Modelling Approach for Green Urban Traffic Management","UNIVERSITE GUSTAVE EIFFEL","€1,975,500","The MAGnUM project aims to (i) create a consistent set of interrelated dynamic and multimodal traffic models able to capture driver behaviours at the different urban scales and (ii) apply this variety of models to design efficient and green traffic management strategies.Traffic flow dynamics is well reproduced at a local urban scale by the kinematic wave model and its numerous extensions. Even if this model is parsimonious compared to other modelling approaches, it can hardly be applied at large",{"id":604,"funder":7,"programme":8,"title":605,"piName":10,"institution":606,"country":52,"year":13,"amount":607,"abstract":608},"cordis-european-research-council-award-647019","A Comparative History of Insurance Law in Europe","UNIVERSITAET AUGSBURG","€1,992,500","The objective of the project is to work out interactions between the national developments of insurance law in Europe, to explore the possibility of common historical roots of European insurance law, and to reassess the history of insurance law in Europe. The project does, thereby, aim at creating a historical basis for a European legal scholarship in the field of insurance law.Today’s state of research in the field of the history of insurance law is unsatisfactory: with the exception of maritim",{"id":610,"funder":7,"programme":8,"title":611,"piName":10,"institution":612,"country":613,"year":13,"amount":614,"abstract":615},"cordis-european-research-council-award-648575","Light-Vapour Interactions at the Nanoscale","THE HEBREW UNIVERSITY OF JERUSALEM","IL","€1,998,863","The goal of this research is to develop a chip scale toolkit for exploring light-vapour interactions at the nanoscale. The integration of hot vapour cells with nanophotonics technology will be used for enhancing the interaction of light with vapours and for constructing miniaturized devices. Our main objectives are: I-developing an advanced and versatile platform which allows for the construction of miniaturized devices bringing together photonics\u002Fplasmonics and atomic vapours. II-exploring the ",{"id":617,"funder":7,"programme":8,"title":618,"piName":10,"institution":619,"country":183,"year":13,"amount":10,"abstract":620},"cordis-european-research-council-award-648787","Atomic layer deposition of two-dimensional transition metal dichalcogenide nanolayers","TECHNISCHE UNIVERSITEIT EINDHOVEN","Two-dimensional transition metal dichalcogenides (2D-TMDs) are an exciting class of new materials. Their ultrathin body, optical band gap and unusual spin and valley polarization physics make them very promising candidates for a vast new range of (opto-)electronic applications. So far, most experimental work on 2D-TMDs has been performed on exfoliated flakes made by the ‘Scotch tape’ technique. The major next challenge is the large-area synthesis of 2D-TMDs by a technique that ultimately can be ",{"id":622,"funder":7,"programme":8,"title":623,"piName":10,"institution":624,"country":52,"year":13,"amount":625,"abstract":626},"cordis-european-research-council-award-646747","N2 as Chemical Feedstock – Synthetic Nitrogen Fixation beyond Haber-Bosch","GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS","€1,998,500","The chemical transformation of dinitrogen is one of the most important industrial processes. Thereby produced ammonia serves as nitrogen source for almost any synthetic nitrogen containing compound, such as fertilizers or many polymers and pharmaceuticals. However, despite forcing conditions associated with high energy consumption, the Haber-Bosch process gives low yields in NH3. Hence, homogeneous, bioinspired nitrogen fixation is a longstanding goal, yet with very limited success. In this prop",{"id":628,"funder":7,"programme":8,"title":629,"piName":10,"institution":409,"country":20,"year":13,"amount":630,"abstract":631},"cordis-european-research-council-award-648328","Quantum Metamaterials: A Theoretical and Computational Approach Towards Seamlessly Integrated Hybrid Classical\u002FQuantum Nano-structures","€1,779,240","The overarching aim of this proposal is to initiate and advance an integrated theoretical and computational research programme in an emerging area of metamaterials research, namely Quantum Metamaterials. Thus, it is commonly believed that one of the most noteworthy developments witnessed in the last decade in physical sciences and engineering is the emergence of metamaterials. Unlike ordinary materials, which are assembled at the atomic level, metamaterials are composite materials built up from ",{"id":633,"funder":7,"programme":8,"title":634,"piName":10,"institution":635,"country":59,"year":13,"amount":636,"abstract":637},"cordis-european-research-council-award-647550","Unconventional Bifunctional Catalysts","UNIVERSIDAD AUTONOMA DE MADRID","€1,987,750","The development of sustainable chemical processes is one of the most important features in modern chemistry. It has become a key research area worldwide providing solutions to important societal demands by optimizing the use of natural resources and minimizing waste and environmental impact. Among the relevant methods for achieving this goal, catalysis represents a key and central approach. Both Organocatalysis and Metal Catalysis have emerged as solutions to the problems in this context. In thi",{"id":639,"funder":7,"programme":8,"title":640,"piName":10,"institution":641,"country":52,"year":13,"amount":642,"abstract":643},"cordis-european-research-council-award-648365","Self-replicating Colloidal Assemblies","FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV","€1,907,325","Self-replication is the preeminent property of living systems and natural materials. Nature builds and repairs by self-replication. Purely synthetic materials so far lack this important ability. An indispensable prerequisite is the multi-directional control of interactions between the building blocks of materials. In order to generate colloidal building blocks, which are able to self-replicate in a non-biological two-step process, i.e. without the use of DNA, we propose to create a new class of ",{"id":645,"funder":7,"programme":8,"title":646,"piName":10,"institution":647,"country":20,"year":13,"amount":648,"abstract":649},"cordis-european-research-council-award-646809","Data Intensive Modelling of the Rhizosphere Processes","UNIVERSITY OF SOUTHAMPTON","€1,996,246","We rely on soil to support the crops on which we depend. Less obviously we also rely on soil for a host of 'free services' from which we benefit. For example, soil buffers the hydrological system greatly reducing the risk of flooding after heavy rain; soil contains very large quantities of carbon, which would otherwise be released into the atmosphere where it would contribute to climate change. Given its importance it is not surprising that soil, especially its interaction with plant roots, has ",{"id":651,"funder":7,"programme":8,"title":652,"piName":10,"institution":31,"country":32,"year":13,"amount":653,"abstract":654},"cordis-european-research-council-award-648428","Perivascular cells at the crossroads of inflammation, regeneration and fibrosis","€1,976,100","The survival of organisms requires the ability to repair tissues upon injury, as well as, after birth, to fight foreign invaders that may have contaminated the wound. This last function is mediated by a complex host response involving immune cells, blood vessels and inflammatory mediators that collectively intend to neutralize the harmful agent and eliminate damaged\u002Fnecrotic tissue. Initially beneficial, this massive inflammatory response comes with a cost, and adult injured tissues usually heal",{"id":656,"funder":7,"programme":8,"title":657,"piName":10,"institution":658,"country":32,"year":13,"amount":101,"abstract":659},"cordis-european-research-council-award-648960","Using a natural cellular plasticity event to decypher the cellular requirements and molecular circuitry promoting transdifferentiation at the single cell level.","CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET EN MEDECINE","How differentiated cells can change their identity is a fascinating question. Indeed, natural interconversions between functionally distinct somatic cell types (aka transdifferentiation, Td) have been reported in species as diverse as jellyfish and mice, while experimentally induced reprogramming of differentiated cells has been demonstrated. The relative ease with which cellular identities can be reprogrammed raises a number of exciting questions: What mechanisms and steps allow a given cell, b",{"id":661,"funder":7,"programme":8,"title":662,"piName":10,"institution":218,"country":20,"year":13,"amount":663,"abstract":664},"cordis-european-research-council-award-646650","Singularity formation in nonlinear evolution equations","€1,211,055","Non linear wave equations are central in the description of many canonical models in physics from nonlinear optics to fluid mechanics. A phenomenon of particular interest is singularity formation which corresponds to the concentration of the energy of the wave packet. The existence and description of such dynamics is still mostly mysterious, but fundamental progress have been made in the past ten years on canonical models like nonlinear wave and Schr\\odinger equations, with in particular the dis",{"id":666,"funder":7,"programme":8,"title":667,"piName":10,"institution":668,"country":208,"year":13,"amount":669,"abstract":670},"cordis-european-research-council-award-646649","The symplectic geometry of anti-self-dual Einstein metrics","UNIVERSITE LIBRE DE BRUXELLES","€1,162,880","This project is founded on a new formulation of Einstein's equations in dimension 4, which I developed together with my co-authors. This new approach reveals a surprising link between four-dimensional Einstein manifolds and six-dimensional symplectic geometry. My project will exploit this interplay in both directions: using Riemannian geometry to prove results about symplectic manifolds and using symplectic geometry to prove results about Reimannian manifolds.Our new idea is to rewrite Einstein'",{"id":672,"funder":7,"programme":8,"title":673,"piName":10,"institution":674,"country":20,"year":13,"amount":675,"abstract":676},"cordis-european-research-council-award-649101","Modulation of the Ubiquitin Proteasome System During Multiple Stages of the Poxvirus Lifecycle","THE UNIVERSITY OF BIRMINGHAM","€2,270,000","Vaccinia virus (VACV), the prototypic poxvirus, is a large, enveloped, DNA virus characterized by its cytoplasmic site of replication and large subset of genes. Due to the complexity of VACV, the majority of studies focus on the virus rather than the host cell. Thus the repertoire of cell factors and functions required for its replication remain largely unknown. Our previous work to define a subset of these, revealed the cellular degradation machinery as a key requirement of VACV replication. Ou",{"id":678,"funder":7,"programme":8,"title":679,"piName":10,"institution":680,"country":183,"year":13,"amount":101,"abstract":681},"cordis-european-research-council-award-648804","Tumor cell death supports recurrence of cancer","STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS","Introduction: Current anti-cancer treatments are often inefficient, while many patients initially benefit from anti-cancer drugs eventually experience relapse of resistant tumors throughout the body. Current clinical strategies mainly aim at inducing tumor cell death, but this induction may have unintentional and unwanted side effects on surviving tumor cells.Preliminary data: We show that after chemotherapy-induced initial regression, PyMT mammary tumors reappear. During regression, we observe ",{"id":683,"funder":7,"programme":8,"title":684,"piName":10,"institution":685,"country":20,"year":13,"amount":686,"abstract":687},"cordis-european-research-council-award-647969","Nanoencapsulation for Energy Storage and Controlled Release","THE UNIVERSITY OF LIVERPOOL","€2,004,500","The main vision of the project ENERCAPSULE is the development of nanoencapsulation technologies based on switchable nanoscale barriers for novel generation of controlled energy storage and delivery systems. These systems will be based on the “smart” nanocontainers (size below 200 nm) loaded with the energy-enriched active components: materials for thermal energy (both latent and based on chemical reactions) storage and substances for bioenergy (ATP or its components) storage for synthetic biolog",{"id":689,"funder":7,"programme":8,"title":690,"piName":10,"institution":691,"country":20,"year":13,"amount":692,"abstract":693},"cordis-european-research-council-award-647971","Functions of the X chromosome in the mammalian germ line","THE FRANCIS CRICK INSTITUTE LIMITED","€1,912,369","Male and female mammals differ in their sex chromosome complement: males have one X chromosome and one Y chromosome (XY), while females have two X chromosomes (XX). Decades of research have demonstrated that the Y chromosome is crucial for male fertility, regulating both sex differentiation and spermatogenesis. However, the role of the X chromosome in these critical stages of germ line development remains poorly understood.In this proposal, we will explore the functions of the X chromosome in th",{"id":695,"funder":7,"programme":8,"title":696,"piName":10,"institution":218,"country":20,"year":13,"amount":697,"abstract":698},"cordis-european-research-council-award-648909","Lexical Acquisition Across Languages","€1,989,203","Due to the growing volume of textual information available in multiple languages, there is a great demand for Natural Language Processing (NLP) techniques that can automatically process and manage multi-lingual texts, supporting information access and communication in core areas of society (e.g. healthcare, business, science). Many NLP tasks and applications rely on task-specific lexicons (e.g. dictionaries, word classifications) for optimal performance. Recently, automatic acquisition of lexico",{"id":700,"funder":7,"programme":8,"title":701,"piName":10,"institution":218,"country":20,"year":13,"amount":702,"abstract":703},"cordis-european-research-council-award-647685","COMAL:COhesin Mutations in Acute Leukemia: from modeling and mechanisms to novel therapeutics","€1,999,574","Transcriptional dyregulation is a common driver in cancer and acute myeloid leukemia (AML) is an exemplar of this process. AML has a dismal survival rate of \u003C30% with novel targeted therapies urgently required. My research focuses on improving our understanding of the biology of AML and using this knowledge to develop targeted therapies to improve outcomes. Recently loss-of-function mutations in members of the cohesin complex have been described in up to 15% of patients with AML. The cohesin com",{"id":705,"funder":7,"programme":8,"title":706,"piName":10,"institution":707,"country":52,"year":13,"amount":708,"abstract":709},"cordis-european-research-council-award-647215","Light induced spatially EXact and genetically encoded labeling of immune cells for monitoring of lOng Distance and Ultra-compartment Shuttling during autoimmunity and chronic inflammation","KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)","€1,998,063","The incidence of autoimmune diseases including multiple sclerosis is dramatically increasing. While there is a genetically defined “bedrock” susceptibility to develop T cell mediated autoimmunity, environmental cues likely determine the threshold for disease development. Yet, little is known on how environmental cues sensed at body\u002Fenvironment interfaces are translated into immunopathology in distant organs like the central nervous system (CNS).Here, we raise the hypothesis that immune cells mus",{"id":711,"funder":7,"programme":8,"title":712,"piName":10,"institution":713,"country":52,"year":13,"amount":714,"abstract":715},"cordis-european-research-council-award-647035","Spatiotemporal evolution of the hydrological cycle throughout the European continent during past abrupt climate changes","GFZ HELMHOLTZ-ZENTRUM FUR GEOFORSCHUNG","€1,847,546","With global temperatures on the rise due to anthropogenic greenhouse gas emissions, one of the largest short-term threats to societies comes from a changing water cycle: changing ocean currents and atmospheric circulation patterns, increased periods of drought or extreme precipitation events directly affect the socio-economic foundation of communities. However, one of the great unknowns in state-of-the art climate models predicting future changes is the spatial distribution of changing precipita",{"id":717,"funder":7,"programme":8,"title":718,"piName":10,"institution":719,"country":20,"year":13,"amount":720,"abstract":721},"cordis-european-research-council-award-648417","Nucleation of Organic Crystals onto 2D materials","THE UNIVERSITY OF MANCHESTER","€1,922,451","The formation of crystalline solids from liquid-phase precursor is a central idea in materials chemistry. Organic crystal structures can be found in a large number of products, including food, explosives, pigments and pharmaceuticals. Control of molecular assembly is therefore a fundamental problem for both research and industry and it involves substantial scientific and economic challenges. For example, polymorphism is crucial for drug manufacturers because the crystal structure, morphology and",{"id":723,"funder":7,"programme":8,"title":724,"piName":10,"institution":725,"country":183,"year":13,"amount":726,"abstract":727},"cordis-european-research-council-award-647208","Do intermediate-mass black holes exist?","STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN","€1,999,975","With this proposed project I will determine whether intermediate-mass black holes (IMBHs) exist. I propose to use ESA's new Gaia mission, the rich Hubble Space Telescope data archive, and state-of-the-art techniques to investigate systems predicted to exist but not yet found hitherto, such as recoiled hyper-compact stellar systems, red-supergiant mass donors to ultra-luminous X-ray sources, and white dwarf tidal disruption events. The latter can only be detected if black holes with masses less t",{"id":729,"funder":7,"programme":8,"title":730,"piName":10,"institution":409,"country":20,"year":13,"amount":731,"abstract":732},"cordis-european-research-council-award-648716","C9orf72-mediated neurodegeneration: mechanisms and therapeutics","€1,985,699","An expanded GGGGCC repeat in a non-coding region of the C9orf72 gene is the most common known cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The repeat RNA is transcribed and accumulates in neuronal RNA aggregates, implicating RNA toxicity as a key pathogenic mechanism. However, the pathways that lead to neurodegeneration are unknown. My lab has made pioneering contributions to the understanding of C9orf72 FTD\u002FALS, and reported the first structure of the repeat R",{"id":734,"funder":7,"programme":8,"title":735,"piName":10,"institution":736,"country":183,"year":13,"amount":737,"abstract":738},"cordis-european-research-council-award-648718","Technique in the Arts. Concepts, Practices, Expertise (1500-1950)","UNIVERSITEIT UTRECHT","€1,907,944","The transmission of ‘technique’ in art has been a conspicuous ‘black box’ resisting analysis. The tools of the humanities used to study the transmission of ideas and concepts are insufficient when it comes to understanding the transmission of something as non-propositional and non-verbal as ‘technique’. The insights of the neurosciences in, for example, the acquisition and transmission of drawing skills are not yet sufficiently advanced to be historically restrictive. However, only in the most r",{"id":740,"funder":7,"programme":8,"title":741,"piName":10,"institution":742,"country":743,"year":13,"amount":10,"abstract":744},"cordis-european-research-council-award-648298","Reassessing Ninth Century Philosophy. A Synchronic Approach to the Logical Traditions","UNIVERSITAT WIEN","AT","This project aims at a better understanding of the philosophical richness of ninth century thought using the unprecedented and highly innovative method of the synchronic approach. The hypothesis directing this synchronic approach is that studying together in parallel the four main philosophical traditions of the century – i.e. Latin, Greek, Syriac and Arabic – will bring results that the traditional enquiry limited to one tradition alone can never reach. This implies pioneering a new methodology",{"id":746,"funder":7,"programme":8,"title":747,"piName":10,"institution":748,"country":749,"year":13,"amount":750,"abstract":751},"cordis-european-research-council-award-648509","Large Discrete Structures","Masarykova univerzita","CZ","€1,386,859","The proposed project seeks to introduce novel methods to analyze and approximate large graphs and other discrete structures and to apply the developed methods to solve specific open problems. A need for such methods comes from computer science where the sizes of input structures are often enormous. Specifically, the project will advance the recently emerged theory of combinatorial limits by developing new insights in the structure of limit objects and by proposing a robust theory bridging the sp",{"id":753,"funder":7,"programme":8,"title":754,"piName":10,"institution":755,"country":756,"year":13,"amount":757,"abstract":758},"cordis-european-research-council-award-649116","Prosaposin and GPR37 in synucleinopathies","KAROLINSKA INSTITUTET","SE","€1,950,033","The next breakthrough in the treatment of synucleinopathies, incl Parkinson´s disease (PD), will be aimed at interference of disease progression based on insights into the underlying pathogenic process. The pathological hallmark of PD are Lewy bodies (LBs), in which α-synuclein is the major constituent together with other PD-linked gene products (DJ-1, LRRK2, parkin, and GBA) and aggregated GPR37. GPR37 is exceptional among GPCRs having a high propensity for intracellular receptor accumulation a",{"id":760,"funder":7,"programme":8,"title":761,"piName":10,"institution":762,"country":208,"year":13,"amount":763,"abstract":764},"cordis-european-research-council-award-647905","Quantum Tensor Networks and Entanglement","UNIVERSITEIT GENT","€1,927,500","One of the major challenges in theoretical physics is the development of systematic methods for describing and simulating quantum many body systems with strong interactions. Given the huge experimental progress and technological potential in manipulating strongly correlated atoms and electrons, there is a pressing need for such a better theory.The study of quantum entanglement holds the promise of being a game changer for this question. By mapping out the entanglement structure of the low-energy",{"id":766,"funder":7,"programme":8,"title":767,"piName":10,"institution":409,"country":20,"year":13,"amount":768,"abstract":769},"cordis-european-research-council-award-646951","Euler systems and the Birch--Swinnerton-Dyer conjecture","€1,070,473","The Birch--Swinnerton-Dyer conjecture, one of the Millennium Prize Problems, is one of the central unsolved problems in mathematics. It predicts a relation between the arithmetic of an elliptic curve and the properties of the L-function of the elliptic curve. Some special cases of the conjecture were proven by Kolyvagin; the main ingredient in his proof is an algebraic construction called an Euler system. Even though Euler systems are extremely powerful tools, so far only five examples are known",{"id":771,"funder":7,"programme":8,"title":772,"piName":10,"institution":218,"country":20,"year":13,"amount":773,"abstract":774},"cordis-european-research-council-award-647479","The Unfolded Protein Response in Neurodegeneration","€1,979,286","This proposal aims to increase our understanding of the role of translational failure in human neurodegenerative diseases.  We recently discovered the mechanism by which protein misfolding leads to neurodegeneration in prion disease. The pathway involved is a generic cellular pathway, a branch of the unfolded protein response (UPR) that controls protein synthesis at the level of initiation of translation.  Rising levels of misfolded prion protein cause sustained over-activation of the PERK-eIF2α",{"id":776,"funder":7,"programme":8,"title":777,"piName":10,"institution":778,"country":508,"year":13,"amount":779,"abstract":780},"cordis-european-research-council-award-648624","Children of Empires and European Postmemories","CENTRO DE ESTUDOS SOCIAIS","€1,982,475","MEMOIRS focuses on the intergenerational memories of the children and grandchildren of those involved in the decolonization processes of colonies held by France, Portugal and Belgium. Through interviews of this second and third generation, and a comparative analysis of the cultures influenced by the postmemory of the colonial wars and the end of empire, Europe's postcolonial heritage will be reinterrogated, and a new understanding of the contemporary continent will be developed. At the heart of ",{"id":782,"funder":7,"programme":8,"title":783,"piName":10,"institution":784,"country":183,"year":13,"amount":10,"abstract":785},"cordis-european-research-council-award-648916","Embryonic origins of cardiovascular health in later life: disentangling early causal pathways in a lifecourse perspective","ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM","Children born preterm or with a small size at birth have increased risks of cardiovascular disease and type 2 diabetes in adulthood. These intriguing associations strongly suggest that common diseases have at least part of their origins in early fetal life. From both an etiological and preventive perspective, it is important to disentangle the early fetal critical periods and causal pathways. An accumulating body of evidence suggests that early pregnancy, or even the preconception period, may in",{"id":787,"funder":7,"programme":8,"title":788,"piName":10,"institution":223,"country":20,"year":13,"amount":789,"abstract":790},"cordis-european-research-council-award-648283","Modelling of MOF self-assembly, crystal growth and thin film formation","€1,738,715","Metal-organic frameworks (MOFs) constitute one of the most exciting developments in recent nanoporous material science. Synthesised in a self-assembly process from metal corners and organic linkers, a near infinite number of materials can be created by combining different building blocks allowing to fine tune host guest interactions. MOFs are therefore considered promising materials for many applications such as gas separation, drug delivery or sensors for which MOFs in form of nanoparticles, co",{"id":792,"funder":7,"programme":8,"title":793,"piName":10,"institution":581,"country":183,"year":13,"amount":794,"abstract":795},"cordis-european-research-council-award-647426","3D Bioprinting of JOINT Replacements","€1,998,871","The world has a significant medical challenge in repairing injured or diseased joints. Joint degeneration and its related pain is a major socio-economic burden that will increase over the next decade and is currently addressed by implanting a metal prosthesis. For the long term, the ideal solution to joint injury is to successfully regenerate rather than replace the damaged cartilage with synthetic implants. Recent advances in key technologies are now bringing this “holy grail” within reach; reg",{"id":797,"funder":7,"programme":8,"title":798,"piName":10,"institution":784,"country":183,"year":13,"amount":101,"abstract":799},"cordis-european-research-council-award-648268","Towards solving myopia: from genes to pathways using an integrated approach","Background: Myopia (near-sightedness) is a growing public health issue due to its rapidly rising prevalence. In particular high myopia carries a significant risk of blindness for which there are no treatment options. The disease etiology of this trait is complex and largely unknown. We recently identified a large number of disease loci and genes, which provide significant clues for pathogenic pathways. However, they explain only a limited proportion of myopia’s heritability, and the direct funct",{"id":801,"funder":7,"programme":8,"title":802,"piName":10,"institution":762,"country":208,"year":13,"amount":803,"abstract":804},"cordis-european-research-council-award-648124","Laser-induced vapour nanobubbles for intracellular delivery of nanomaterials and treatment of biofilm infections","€2,236,250","Lasers have found widespread application in medicine, such as for photothermal therapy. Gold nanoparticles (AuNPs), are often used as enhancers of the photothermal effect since they can efficiently absorb laser light and convert it into thermal energy. When absorbing intense nano- or picosecond laser pulses, AuNPs can become extremely hot and water vapor nanobubbles (VNBs) can emerge around these particles in tissue. A VNB will expand up to several hundred nm until the thermal energy from the Au",{"id":806,"funder":7,"programme":8,"title":807,"piName":10,"institution":409,"country":20,"year":13,"amount":808,"abstract":809},"cordis-european-research-council-award-648229","Carbon Nanotube Quantum Circuits","€1,998,574","The aim of this proposal is to use spin qubits defined in carbon nanotube quantum dots to demonstrate measurement-based entanglement in an all-electrical and scalable solid-state architecture. The project makes use of spin-orbit interaction to drive spin rotations in the carbon nanotube host system and hyperfine interaction to store quantum information in the nuclear spin states. The proposal builds on techniques developed by the principal investigator for fast and non-invasive read-out of the e",{"id":811,"funder":7,"programme":8,"title":812,"piName":10,"institution":291,"country":158,"year":13,"amount":813,"abstract":814},"cordis-european-research-council-award-648615","Very fast Imaging by Broadband coherent RAman","€1,822,500","The VIBRA project aims at developing an innovative microscope for real-time non-invasive imaging of cells and tissues, which promises to have a revolutionary impact on several fields of biology and medicine. Chemically specific vibrational signatures of molecules enable their direct structural characterization. Reliable and quantitative endogenous bio-markers can be established, e.g., to follow cell differentiation and to identify crucial properties of tissues (malignant vs benign phenotype of a",{"id":816,"funder":7,"programme":8,"title":817,"piName":10,"institution":818,"country":743,"year":13,"amount":819,"abstract":820},"cordis-european-research-council-award-648498","The Fashioning of a Sunni Orthodoxy and the Entangled Histories of Confession-Building in the Early Modern Ottoman Empire, 15th-17th Centuries","CEU GMBH","€1,987,187","How and why did the Ottoman Empire evolve from a fourteenth-century polity where confessional ambiguity between Sunnism and Shiism prevailed into an Islamic state concerned with defining and enforcing a Sunni orthodoxy by the early sixteenth century? Recent historiography attributes this new concern with orthodoxy in the Ottoman Empire to the rise of the rival Shii Safavid Empire at the turn of the sixteenth century. However, the OTTOCONFESSION project is based on the premise that the evolution ",{"id":822,"funder":7,"programme":8,"title":823,"piName":10,"institution":824,"country":20,"year":13,"amount":825,"abstract":826},"cordis-european-research-council-award-648239","Bio-Inspired Tools for Glycoscience","UNIVERSITY OF BRISTOL","€1,986,356","Cell surface carbohydrates play key roles in cell recognition mechanisms. O-glycosylation is a ubiquitous post-translational modification that is highly dynamic and responsive to cellular stimuli through the action of cycling enzymes. Expression of specific O-glycans is linked to changes in gene expression in, for example, inflammatory bowel disease, cystic fibrosis and several types of cancer. Protein-carbohydrate interactions typically exhibit high specificity and weak affinities toward their ",{"id":828,"funder":7,"programme":8,"title":829,"piName":10,"institution":830,"country":52,"year":13,"amount":831,"abstract":832},"cordis-european-research-council-award-648617","Using cis-regulatory mutations to highlight polygenic adaptation in natural plant systems","UNIVERSITAT ZU KOLN","€1,683,120","The goal of this project is to demonstrate that novel aspects of the molecular basis of Darwinian adaptation can be discovered if the polygenic basis of adaptation is taken into account. This project will use the genome-wide distribution of cis-regulatory variants to discover the molecular pathways that are optimized during adaptation via accumulation of small effect mutations. Current approaches include scans for outlier genes with strong population genetics signatures of selection, or large ef",{"id":834,"funder":7,"programme":8,"title":835,"piName":10,"institution":836,"country":183,"year":13,"amount":10,"abstract":837},"cordis-european-research-council-award-648932","Improving the accuracy and reliability of electronic structure calculations: New exchange-correlation functionals from a rigorous expansion at infinite coupling strength","STICHTING VU","By virtue of its computational efficiency, Kohn-Sham (KS) density functional theory (DFT) is the method of choice for the electronic structure calculations in computational chemistry and solid-state physics. Despite its enormous successes, KS DFT’s predictive power and overall usefulness are still hampered by inadequate approximations for near-degenerate and strongly-correlated systems. Crucial examples are transition metal complexes (key for catalysis), stretched chemical bonds (key to predict ",{"id":839,"funder":7,"programme":8,"title":840,"piName":10,"institution":841,"country":52,"year":13,"amount":842,"abstract":843},"cordis-european-research-council-award-647467","Jews and Christians in the East: Strategies of Interaction between the Mediterranean and the Indian Ocean","RUHR-UNIVERSITAET BOCHUM","€1,999,623","This project analyzes Jews in Eastern Christian communities and Eastern Christian sources, beyond the Byzantine context, namely, relations between Jews and Christian communities in the Middle East Central Asia, the Caucasus, Ethiopia, and South India.  In order to obtain a truly accurate understanding of the dynamics of Jewish-Christian relations in the non-Latin world during the Middle Ages, these various regions and traditions must be studied together because they were all profoundly interconn",{"id":845,"funder":7,"programme":8,"title":846,"piName":10,"institution":847,"country":20,"year":13,"amount":10,"abstract":848},"cordis-european-research-council-award-646740","Radical Solutions for Hysteresis in Single-Molecule Magnets","THE UNIVERSITY OF SUSSEX","Single-molecule magnets (SMMs) display magnetic hysteresis that is molecular in origin, and these materials have huge potential to be developed as nano-scale devices. The big challenge is to create SMMs that function without the need for liquid-helium cooling.This project will develop new SMMs that combine the strong magnetic anisotropy of lanthanide ions with a series of novel radical ligands. Our innovative SMMs will have controllable molecular and electronic structures, which will ultimately ",{"id":850,"funder":7,"programme":8,"title":851,"piName":10,"institution":218,"country":20,"year":13,"amount":10,"abstract":852},"cordis-european-research-council-award-648613","Quantum magnonics in insulators","In the QUMIN proposal we will build on recent developments in spintronics, circuit quantum electrodynamics and superconducting quantum computing in order to advance the fledgling research field of quantum magnonics. We will employ micro-scale magnonic resonators fabricated from YIG thin films and planar superconducting microwave resonators and superconducting transmon qubits. The combination of these basic elements will enable us to create hybrid magnon\u002Fphoton and magnon\u002Fqubit quantum states and",{"id":854,"funder":7,"programme":8,"title":855,"piName":10,"institution":856,"country":59,"year":13,"amount":857,"abstract":858},"cordis-european-research-council-award-648276","A Unified Theory of Algorithmic Relaxations","UNIVERSITAT POLITECNICA DE CATALUNYA","€1,725,656","For a large family of computational problems collectively known as constrained optimization and satisfaction problems (CSPs), four decades of research in algorithms and computational complexity have led to a theory that tries to classify them as algorithmically tractable vs. intractable, i.e.  polynomial-time solvable vs. NP-hard. However, there remains an important gap in our knowledge in that many CSPs of interest resist classification by this theory. Some such problems of practical relevance ",{"id":860,"funder":7,"programme":8,"title":861,"piName":10,"institution":285,"country":20,"year":13,"amount":10,"abstract":862},"cordis-european-research-council-award-647954","Neural oscillations - a code for memory","Episodic memory refers to the fascinating human ability to remember past events in a highly associative and information rich way. But how are these memories coded in human brains? Any mechanism accounting for episodic memory must accomplish at least two functions: to build novel associations, and to represent the information constituting the memory. Neural oscillations, regulating the synchrony of neural assemblies, are ideally suited to accomplish these two functions, but in opposing ways. On t",{"id":864,"funder":7,"programme":8,"title":865,"piName":10,"institution":248,"country":52,"year":13,"amount":866,"abstract":867},"cordis-european-research-council-award-648505","From Cloud to Star Formation","€1,616,050","Star Formation is a hierarchical process from the build-up of large clouds to the assembly of stars. This ERC project aims at studying the multi-scale processes of this conversion from diffuse gas to stars. The fundamental data are provided by two PI-led large observing programs at two of the most advanced radio and mm interferometers, the Very Large Array (VLA) and the Plateau de Bure Interferometer (PdBI). This combined approach is designed to address outstanding key questions in the field of ",{"id":869,"funder":7,"programme":8,"title":870,"piName":10,"institution":871,"country":52,"year":13,"amount":872,"abstract":873},"cordis-european-research-council-award-647328","Site-directed RNA Editing to Manipulate RNA and Protein Function","EBERHARD KARLS UNIVERSITAET TUEBINGEN","€1,808,200","Enzymatically active RNA-guided proteins, like the RNA-induced silencing complex (RISC), are particularly versatile tools for the rationally programmed manipulation of genetic information. After successful re-addressing of various natural RNA-guided machineries it is now time to tackle the engineering of novel, user-defined tools. With this respect we have recently achieved the engineering of an RNA-guided adenosine-to-inosine RNA editing machinery. Since inosine is biochemically read as guanosi",{"id":875,"funder":7,"programme":8,"title":876,"piName":10,"institution":877,"country":20,"year":13,"amount":878,"abstract":879},"cordis-european-research-council-award-649111","OlfSwitch: Neural circuit switches from molecules to behaviour","UNITED KINGDOM RESEARCH AND INNOVATION","€1,990,791","This proposal seeks to understand the logic of neural circuit switches in the relatively simple nervous system of Drosophila. Our goals are to examine the developmental, physiological and behavioural logic of several of these elementary circuit motifs. We will use innate olfactory behaviour as our primary model, investigating behaviours triggered by single or convergent odour stimuli and their modulation by memory and internal state. We will start with the favourable case of a sexually dimorphic",{"id":881,"funder":7,"programme":8,"title":882,"piName":10,"institution":647,"country":20,"year":13,"amount":883,"abstract":884},"cordis-european-research-council-award-648630","Integrable Structures in Quantum Field Theory","€1,992,452","Quantum field theory forms the foundation of our understanding of elementary particle physics. It provides the theoretical background for the interpretation of data from collider experiments. While quantum field theory is an old subject, over the last decade new features have begun to emerge which reveal new ways to understand it. In particular an astonishing simplicity has been found at the heart of the maximally supersymmetric gauge theory in four spacetime dimensions, a close cousin of Quantu",{"id":886,"funder":7,"programme":8,"title":887,"piName":10,"institution":624,"country":52,"year":13,"amount":888,"abstract":889},"cordis-european-research-council-award-648329","Groups, Representations and Analysis in Number Theory","€1,374,250","The last decade has seen remarkable progress in the study of growth in infinite families of groups. The main approach has its roots in additive combinatorics, but has truly given fruit in a non-commutative context. It is becoming clear that the central role is played not by groups in isolation, but by actions of groups. It is from this perspective that my plan addresses, at the same time, questions on growth in groups as such and hard problems in analytic number theory.While this line of researc",{"id":891,"funder":7,"programme":8,"title":892,"piName":10,"institution":893,"country":158,"year":13,"amount":894,"abstract":895},"cordis-european-research-council-award-648670","Synthetic Lethal Phenotype Identification through Cancer Evolution Analysis","UNIVERSITA DEGLI STUDI DI TRENTO","€1,996,428","Prostate cancer (PCA) is a genetically heterogeneous disease. Advances in targeted hormonal therapy (second generation anti-androgens) have led to more effective management of castration-resistant prostate cancer (CRPC). Despite these highly potent drugs, disease recurs with new genomic and epigenetic alterations. In this ERC proposal, I will leverage my expertise in cancer genomics and a new computational methodology to unravel the landscape of lethal PCA, with a focus on determining the Achill",{"id":897,"funder":7,"programme":8,"title":898,"piName":10,"institution":899,"country":20,"year":13,"amount":10,"abstract":900},"cordis-european-research-council-award-648841","The Cog in the Ratchet: Illuminating the Cognitive Mechanisms Generating Human Cumulative Culture","THE UNIVERSITY OF STIRLING","In human populations, skills and knowledge accumulate over generations, giving rise to behaviours and technologies far more complex than any single individual could achieve alone. This ratchet-like property of human culture appears absent in nonhuman species, as socially transmitted behaviours in animal populations are generally no more complex than those that can be acquired by trial and error. Scientists from a wide range of disciplines have offered high-profile speculative theories about the ",{"id":902,"funder":7,"programme":8,"title":903,"piName":10,"institution":904,"country":208,"year":13,"amount":10,"abstract":905},"cordis-european-research-council-award-649082","Bacterial Amyloid Secretion: Structural Biology and Biotechnology.","VIB VZW","Curli are functional amyloid fibers that constitute the major protein component of the extracellular matrix in pellicle biofilms formed by Bacteroidetes and Proteobacteria.  Unlike the protein misfolding and aggregation events seen in pathological amyloid diseases such as Alzheimer’s and Parkinson’s disease, curli are the product of a dedicated protein secretion machinery. Curli formation requires a specialised and mechanistically unique transporter in the bacterial outer membrane, as well as tw",{"id":907,"funder":7,"programme":8,"title":908,"piName":10,"institution":824,"country":20,"year":13,"amount":909,"abstract":910},"cordis-european-research-council-award-648667","Photonic Quantum Computing","€2,009,429","This CoG will simultaneously address the outstanding research challenges to establishing the feasibility of large-scale photonic quantum computing by:1.    designing, fabricating and optimising the required hardware (WP1) components—inc. waveguides, couplers, phase shifters, delays, interconnects, spectral filters, photon sources and detectors, and control electronics2.    establishing paths to the integration (WP2) of these components into complete systems3.    developing accurate, exhaustive a",{"id":912,"funder":7,"programme":8,"title":913,"piName":10,"institution":736,"country":183,"year":13,"amount":101,"abstract":914},"cordis-european-research-council-award-647570","Estuaries shaped by biomorphodynamics, inherited landscape conditions and human interference","ESTUARIES are shallow coastal water bodies with river inflow shaped by biomorphological processes, with patterns of channels and shoals, sand\u002Fmud flats, tidal marshes, vegetated banks and peat. Development was influenced by early Holocene landscape that drowned under sealevel rise, and by human interference. Estuaries harbour highly productive natural habitats and are of pivotal economic importance for food production, access to harbours and urban safety. Accelerating sealevel rise, changing riv",{"id":916,"funder":7,"programme":8,"title":917,"piName":10,"institution":918,"country":32,"year":13,"amount":919,"abstract":920},"cordis-european-research-council-award-647870","Social Preferences, Well-Being and Policy","FONDATION NATIONALE DES SCIENCES POLITIQUES","€1,569,820","The goal of my project is to develop advanced research into the foundations of social preferences and well-being. If high value is placed on social cooperation and well-being for human development, then it becomes an urgent task to elaborate appropriate theories and measures, to understand their foundations, and to identify policies that will enhance them.  I will advance this research in three steps: 1) The first stage will break new ground in the theory and measurement of social preferences an",{"id":922,"funder":7,"programme":8,"title":923,"piName":10,"institution":830,"country":52,"year":13,"amount":924,"abstract":925},"cordis-european-research-council-award-646714","Reading Global. Constructions of World Literature and Latin America","€1,965,250","The debate on world literature is among the most significant cultural historical controversies of our time. This contribution to the debate aims to pursue two goals in particular:a) A groundbreaking theoretical approach to the current shift in focus of the concept of World Literature that will involve both the displacement of Eurocentric forms of knowledge and a comprehensive review of selection processes in a globalized publishing world. b) An innovative investigation of the production and sele",{"id":927,"funder":7,"programme":8,"title":928,"piName":10,"institution":929,"country":183,"year":13,"amount":930,"abstract":931},"cordis-european-research-council-award-647209","Psychosystems: Consolidating Network Approaches to Psychopathology","UNIVERSITEIT VAN AMSTERDAM","€1,959,690","I have recently introduced the Network Approach to Psychopathology. This approach is based on the interpretation of mental disorders as causal systems. Such systems have two basic building blocks: symptoms (i.e., problems like insomnia, fatigue, and concentration problems) and connections between symptoms (i.e., causal and homeostatic relations, such as insomnia → fatigue → concentration problems). Together, these building blocks constitute a network, which can be analyzed as a complex system. I",{"id":933,"funder":7,"programme":8,"title":934,"piName":10,"institution":935,"country":52,"year":13,"amount":936,"abstract":937},"cordis-european-research-council-award-647858","GENEtic DiSsection of Innate Immune Sensing and Signalling","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€1,970,000","In vertebrates, a receptor-based, innate sensing machinery is used to detect the presence of microbederived molecules or the perturbation microbial infection causes within the host. In the context of viral infection, non-self nucleic acids are sensed by a set of intracellular receptors that upon activation initiate broad antiviral effector responses to eliminate the imminent threat. Over the past years our understanding of these processes has considerably grown, mainly by employing murine knocko",{"id":939,"funder":7,"programme":8,"title":940,"piName":10,"institution":514,"country":20,"year":13,"amount":10,"abstract":941},"cordis-european-research-council-award-647939","Lighting up the dark - the evolution of dust throughout cosmic time","After more than two decades of infrared astronomy, we still know very little about the origin and evolution of cosmic dust in galaxies, responsible for obscuring half of all starlight since the Big Bang. This obscured starlight is re-radiated in a region of the electromagnetic spectrum that is still relatively unexplored. Herschel provides a unique opportunity to resolve this by revealing the 90% of dust too cold to be detected before, yet only a tiny fraction of the largest survey of the sky ca",{"id":943,"funder":7,"programme":8,"title":944,"piName":10,"institution":945,"country":90,"year":13,"amount":946,"abstract":947},"cordis-european-research-council-award-648179","Connecting the Extreme","KOBENHAVNS UNIVERSITET","€1,999,526","Advances in technology and methodology over the last decade, have enabled the study of galaxies to the highest redshifts. This has revolutionized our understanding of the origin and evolution of galaxies. I have played a central role in this revolution, by discovering that at z=2, when the universe was only 3 Gyr old, half of the most massive galaxies were extremely compact and had already completed their star formation. During the last five years I have led a successful group of postdocs and st",{"id":949,"funder":7,"programme":8,"title":950,"piName":10,"institution":685,"country":20,"year":13,"amount":951,"abstract":952},"cordis-european-research-council-award-648440","Selective Barriers to Horizontal Gene Transfer","€1,820,865","Horizontal gene transfer (HGT) is a form of genic inheritance that occurs between individuals in a population or between species rather than from parent to offspring. HGT is most prevalent in bacteria, where it is an important source of novel metabolic pathways, pathogenicity factors, and antibiotic resistance.In spite of the importance of HGT, we understand little about  the evolutionary barriers to HGT. This proposal will outline a systematic experimental approach to elucidate factors that sel",{"id":954,"funder":7,"programme":8,"title":955,"piName":10,"institution":956,"country":20,"year":13,"amount":957,"abstract":958},"cordis-european-research-council-award-646928","Fulfilling the Potential of Globular Clusters as Tracers of Cosmological Mass Assembly","LIVERPOOL JOHN MOORES UNIVERSITY","€1,429,439","Globular clusters (GCs) are among the oldest luminous sources in the universe, bearing witness to theearliest stages of galaxy formation as well as their evolution to the present day. While GCs have played apivotal role in our understanding of the assembly of galaxies, their full potential remains unfulfilled due toour lack of understanding of how they form. One of the largest stumbling blocks has been the anomalouschemistry (both metallicity distributions and abundance patterns) of GCs relative",{"id":960,"funder":7,"programme":8,"title":961,"piName":10,"institution":962,"country":59,"year":13,"amount":963,"abstract":964},"cordis-european-research-council-award-648429","The Transformation of Popular Politics in Europe’s Long Nineteenth Century","UNIVERSIDAD CARLOS III DE MADRID","€1,133,396","How did ordinary people acquire the capacity to mobilize and influence the political decision-making process? How did standard forms of popular collective action emerge and get institutionalized in European modernity? To address these questions, this project explores the transformation of European popular politics in the long nineteenth-century (c. 1789-1914), while also offering a systematic and empirically rigorous causal account of the processes that led to the emergence of the typical forms ",{"id":966,"funder":7,"programme":8,"title":967,"piName":10,"institution":871,"country":52,"year":13,"amount":968,"abstract":969},"cordis-european-research-council-award-648084","Functional in vivo analysis of cholangiocarcinoma development, progression and metastasis.","€1,998,898","Genetic heterogeneity and complexity are hallmarks of metastatic solid tumors and therapy resistance inevitably develops upon treatment with cytotoxic drugs or molecular targeted therapies. Cholangiocarcinoma (CCC, or bile duct cancer) represents the second most frequent primary liver tumor and has emerged as a health problem with sharply increasing incidence rates, in particular of intrahepatic CCC (ICC). The reason for increased CCC incidence remains unclear, but influences of western lifestyl",{"id":971,"funder":7,"programme":8,"title":972,"piName":10,"institution":973,"country":59,"year":13,"amount":974,"abstract":975},"cordis-european-research-council-award-647301","A Chemical Approach to Molecular Spin Qubits: Decoherence and Organisation of Rare Earth Single Ion Magnets","UNIVERSITAT DE VALENCIA","€1,827,375","Coordination Chemistry and Molecular Magnetism are in an ideal position for the rational design of Single-Molecule Magnets which can be used as molecular spin qubits, the irreducible components of any quantum technology. Indeed, a major advantage of molecular spin qubits over other candidates stems from the power of Chemistry for a tailored and inexpensive synthesis of systems for their experimental study. In particular, the so-called Lanthanoid-based Single-Ion Magnets, which are currently the ",{"id":977,"funder":7,"programme":8,"title":978,"piName":10,"institution":979,"country":20,"year":13,"amount":101,"abstract":980},"cordis-european-research-council-award-647849","Structural and mechanistic insights into RING E3-mediated ubiquitination","BEATSON INSTITUTE FOR CANCER RESEARCH LBG","Ubiquitin (Ub) conjugation regulates a myriad of cellular processes in the eukaryotic cell. Ub-ligases (E3) play a pivotal role in deciding the substrate’s fate and function by catalyzing the transfer of Ub from Ub-conjugating enzyme (E2) to a substrate protein lysine sidechain. Successive rounds of E3-catalyzed substrate ubiquitination lead to the formation of poly-Ub chains or multi-monoubiquitination, which direct the substrate to different biological fates such as degradation by the 26S prot",{"id":982,"funder":7,"programme":8,"title":983,"piName":10,"institution":984,"country":158,"year":13,"amount":985,"abstract":986},"cordis-european-research-council-award-646867","Learning From Failing and Passing Executions At the Speed of Internet","UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA","€1,141,875","Modern software systems must be extremely flexible and easily adaptable to different user needs and environments. However, this flexibility also introduces relevant quality issues. These problems are so common that is sufficient browsing the Web to find millions of reports about failures observed after updates and incompatibilities caused by the interaction of a newly installed component with the existing components. The impact of problems introduced by end-users can be dramatic because end-user",{"id":988,"funder":7,"programme":8,"title":989,"piName":10,"institution":929,"country":183,"year":13,"amount":10,"abstract":990},"cordis-european-research-council-award-648496","Migration as Development","How do processes of development and social transformation shape human migration? More specifically, how do  development process affect the geographical orientation, timing, composition and volume of both internal and international migration? The relation between development and human mobility is highly contested. While economic development in poor countries and areas is usually seen as the most effective way to reduce migration, other studies suggest that development actually increases migration",{"id":992,"funder":7,"programme":8,"title":993,"piName":10,"institution":994,"country":508,"year":13,"amount":995,"abstract":996},"cordis-european-research-council-award-647888","Molecular mechanisms of induced protection against sepsis by DNA damage responses","FUNDACAO CALOUSTE GULBENKIAN","€1,985,375","Severe sepsis remains a poorly understood systemic inflammatory condition with high mortality rates and limited therapeutic options outside of infection control and organ support measures. Based on our recent discovery that anthracycline drugs prevent organ failure without affecting the bacterial burden in a model of severe sepsis, we propose that strategies aimed at target organ protection have extraordinary potential for the treatment of sepsis and possibly for other inflammation-driven condit",{"id":998,"funder":7,"programme":8,"title":999,"piName":10,"institution":1000,"country":52,"year":13,"amount":1001,"abstract":1002},"cordis-european-research-council-award-648711","Gain by Strain: Precise Cuts of Cyclopropanes as Key to Molecular Complexity","TECHNISCHE UNIVERSITAET BRAUNSCHWEIG","€1,994,250","A central discipline of chemistry is the design und creation of molecules with defined structural and chemical properties. Stretching synthetic horizons is a never-ending endeavor to inspirit the chemist’ s creativity in preparing compounds and materials yet to be discovered. Relying on their high strain energy cyclopropanes, as carriers of the most fundamental ring geometry, offer a unique reactivity which allows for a multitude of transformations being grouped in ring-opening reactions, cycloa",{"id":1004,"funder":7,"programme":8,"title":1005,"piName":10,"institution":1006,"country":183,"year":13,"amount":1007,"abstract":1008},"cordis-european-research-council-award-646667","Set in Stone - A retrospective impact assessment of human and environmental resource usage in Late Bronze Age Mycenaean Monumental Architecture, Greece","UNIVERSITEIT LEIDEN","€1,975,200","Greek Mycenaean monumental architecture has been well-studied. However, the extent to which large-scale building programmes contributed to the socioeconomic and political changes and crises that took place in Late Bronze Age Greece (c.1600-1100\u002F1070 BC) has not been studied. The project aims to investigate human and natural resources which interacted in the Argive Plain and Attica. There, elites mobilized these resources to implement their monumental building programmes. It seeks to reveal how a",{"id":1010,"funder":7,"programme":8,"title":1011,"piName":10,"institution":1012,"country":613,"year":13,"amount":1013,"abstract":1014},"cordis-european-research-council-award-647474","In-cell NMR monitoring of alpha-Synuclein aggregation in neuronal cells","WEIZMANN INSTITUTE OF SCIENCE","€1,996,500","Intracellular aggregation of the human amyloid protein alpha-synuclein is causally involved in Parkinson’s disease, a debilitating neurodegenerative disorder. The goal of this project is to combine low-resolution, fluorescence-imaging methods with high-resolution in-cell NMR and EPR spectroscopy techniques to derive macroscopic and microscopic insights into alpha-synuclein aggregate structures directly in neuronal cells.   To achieve this goal, we will employ different sets of cultured neurons a",{"id":1016,"funder":7,"programme":8,"title":1017,"piName":10,"institution":1018,"country":613,"year":13,"amount":1019,"abstract":1020},"cordis-european-research-council-award-646868","Distinct Infection Dynamics and Ecological Success among Closely Related Marine Cyanophages: Why the Differences?","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","€2,162,296","Viruses are extremely abundant in the oceans and majorly impact the marine ecosystem by influencing the abundance, diversity and evolution of their hosts. However, our understanding of marine viral physiology and ecology among different members of the virus community is conspicuously lacking. Preliminary data using a newly developed molecular method revealed drastic differences in field abundances of two subtypes of T7-like podoviruses that infect marine cyanobacteria. Moreover, these subtypes d",{"id":1022,"funder":7,"programme":8,"title":1023,"piName":10,"institution":945,"country":90,"year":13,"amount":1024,"abstract":1025},"cordis-european-research-council-award-648039","Systematic Decoding of Deubiquitylase-Regulated Signaling Networks","€1,972,570","Cellular processes are largely governed by sophisticated protein posttranslational modification (PTM)-dependent signaling networks, and a systematic understanding of regulatory PTM-based networks is a key goal in modern biology. Ubiquitin is a small, evolutionarily conserved signaling protein that acts as a PTM after being covalently conjugated to other proteins. Reversible ubiquitylation forms the most versatile and largest eukaryote-exclusive signaling system, and regulates the stability and f",{"id":1027,"funder":7,"programme":8,"title":1028,"piName":10,"institution":1029,"country":1030,"year":13,"amount":1031,"abstract":1032},"cordis-european-research-council-award-648017","Asymptotic invariants of discrete groups, sparse graphs and locally symmetric spaces","HUN-REN RENYI ALFRED MATEMATIKAI KUTATOINTEZET","HU","€1,386,250","The PI proposes to study the asymptotic behavior of various invariants of discrete groups and their actions, of sparse graphs and of locally symmetric spaces. The game is to connect the asymptotic behavior of an invariant on a sequence of finite models to an analytic invariant on a suitable limit object of the sequence and then use the connection to get new results in both the finite and infinite worlds. The recently emerging notion of invariant random subgroups, initiated by the PI, serves as a",{"id":1034,"funder":7,"programme":8,"title":1035,"piName":10,"institution":973,"country":59,"year":13,"amount":1036,"abstract":1037},"cordis-european-research-council-award-647423","Statistical Learning for Earth Observation Data Analysis.","€1,716,954","SEDAL is an interdisciplinary project that aims to develop novel statistical learning methods to analyze Earth Observation (EO) satellite data. In the last decade, machine learning models have helped to monitor land, oceans, and atmosphere through the analysis and estimation of climate and biophysical parameters. Current approaches, however, cannot deal efficiently with the particular characteristics of remote sensing data. In the coming few years, this problem will largely increase: several sat",{"id":1039,"funder":7,"programme":8,"title":1040,"piName":10,"institution":1041,"country":20,"year":13,"amount":1042,"abstract":1043},"cordis-european-research-council-award-647557","Small Summaries for Big Data","UNIVERSITY OF WARWICK","€1,565,502","A fundamental challenge in processing the massive quantities of information generated by modern applications is in extracting suitable representations of the data that can be stored, manipulated and interrogated on a single machine.  A promising approach is in the design and analysis of compact summaries: data structures which capture key features of the data, and which can be created effectively over distributed data sets.  Popular summary structures include the Bloom filter, which compactly re",{"id":1045,"funder":7,"programme":8,"title":1046,"piName":10,"institution":929,"country":183,"year":13,"amount":1047,"abstract":1048},"cordis-european-research-council-award-647314","Becoming Men: Performing responsible masculinities in contemporary urban Africa","€1,999,830","This anthropological study examines the reconfiguration of masculinities in urban Africa over the last 30 years. Focusing on how practices and discourses of empowerment and equality shape male subjectivities, this study builds upon a significant body of nuanced research on masculinities in Africa. Since the mid-1980s academic and public discourses have depicted African masculinity as both precarious and predatory. Economic insecurity, urbanization, shifting gender norms, and growing gender parit",{"id":1050,"funder":7,"programme":8,"title":1051,"piName":10,"institution":1052,"country":508,"year":13,"amount":141,"abstract":1053},"cordis-european-research-council-award-647596","Integration of Capacitor, Thermoelectric and PhotoVoltaic thin films for efficient energy conversion and storage","NOVA ID FCT - ASSOCIACAO PARA A INOVACAO E DESENVOLVIMENTO DA FCT","The possibility of having a unique device that converts thermal and photonics energy into electrical energy and simultaneously stores it, is something dreamed by the PI since the beginning of her research career. To achieve that goal, this project aims to gather, in a single substrate, solar cells with up-conversion nanoparticles, thermoelectrics and graphene super-capacitor, all made of thin films. These three main components will be developed separately and integrated sequentially. The innovat",{"id":1055,"funder":7,"programme":8,"title":1056,"piName":10,"institution":1057,"country":208,"year":13,"amount":1058,"abstract":1059},"cordis-european-research-council-award-646802","Reinventing paternalism. The micropolitics of work in the mining companies of Central Africa","UNIVERSITE DE LIEGE","€1,650,165","In the course of the last decade, African countries rich in mineral resources have experienced an unprecedented boom in mining investment. The copperbelt that crosses the border between Zambia and Congo, where our research will be carried out, represents one of the most striking cases of this “new scramble for Africa”: mining companies of various sizes and origins have flocked to these countries of central Africa to take over the assets of public enterprises and to develop new mining projects. T",{"id":1061,"funder":7,"programme":8,"title":1062,"piName":10,"institution":1063,"country":183,"year":13,"amount":101,"abstract":1064},"cordis-european-research-council-award-648855","Ion-gated Interfaces for Quantum Phase Devices","RIJKSUNIVERSITEIT GRONINGEN","The aim of this ERC proposal is to develop a highly efficient tunable interface with ion-movement-mediated gating as a rich platform for novel electronic devices by using field effect controlling of quantum phase transitions. Working beyond conventional FETs, the new transistors will be build by combining novel layered semiconductor films grown by the CVD method: newly synthesized ionic material; and a well-defined interface optimized by surface analysis techniques; which jointly are able to boo",{"id":1066,"funder":7,"programme":8,"title":1067,"piName":10,"institution":1068,"country":59,"year":13,"amount":1069,"abstract":1070},"cordis-european-research-council-award-648201","Description of information transfer across macromolecules by concerted conformational changes","FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)","€1,950,000","Signal transduction in biology relies on the transfer of information across biomolecules by concerted conformational changes that cannot currently be characterized experimentally at high resolution. In CONCERT we will develop a method based on the use of nuclear magnetic resonance spectroscopy in solution that will provide very detailed descriptions of such changes by using the information about structural heterogeneity contained in a parameter that is exquisitely sensitive to molecular shape ca",{"id":1072,"funder":7,"programme":8,"title":1073,"piName":10,"institution":1074,"country":183,"year":13,"amount":10,"abstract":1075},"cordis-european-research-council-award-646840","Stromal cells as primary drivers of immunopathology: towards targeted disease modification in spondyloarthritis","ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM","Pro-inflammatory cytokines play a crucial role in chronic inflammatory diseases. Focusing on spondyloarthritis (SpA), a prevalent and debilitating rheumatic condition characterized by inflammation and abnormal new bone formation, we demonstrated that TNF and IL-23\u002FIL-17 inhibition potently blocks inflammation. However, these treatments have no proven effect on pathologic new bone formation and the resulting structural damage, indicating the unmet need for understanding upstream disease mechanism",{"id":1077,"funder":7,"programme":8,"title":1078,"piName":10,"institution":1079,"country":20,"year":13,"amount":1080,"abstract":1081},"cordis-european-research-council-award-646927","Not all minds that wander are lost: A neurocognitive test of mind-wandering state’s contribution to human cognition.","UNIVERSITY OF YORK","€1,800,000","Experience does not always arise from the events in the immediate environment; research has shown that states such as mind-wandering occupy almost half of our waking thought. Although mind-wandering has gained a foothold in cognitive science, our understanding of this core form of cognition is piecemeal and disjointed, making it a regular topic of theoretical debates in high-profile journals (e.g. Science and Psychological Bulletin). I have argued that these controversies are due to the lack of ",{"id":1083,"funder":7,"programme":8,"title":1084,"piName":10,"institution":1012,"country":613,"year":13,"amount":101,"abstract":1085},"cordis-european-research-council-award-646604","Systematic exploration of peroxisomal structure and function","Peroxisomes are ubiquitous and dynamic organelles that house many important pathways of cellular metabolism. This key organelle propagates cellular signals for differentiation, development and metabolism, and thus it is no surprise that a large number of diseases, including metabolic disorders, have been linked to peroxisomal dysfunction. Despite the importance of peroxisomes many fundamental questions remain open. For example, we do not know the entire proteome of peroxisomes, the extent of the",{"id":1087,"funder":7,"programme":8,"title":1088,"piName":10,"institution":218,"country":20,"year":13,"amount":1089,"abstract":1090},"cordis-european-research-council-award-648609","Winter Rain, Summer Rain: Adaptation, Climate Change, Resilience and the Indus Civilisation","€1,999,439","Rainfall systems are complex and inherently variable, yet they are of fundamental importance due to their impact on food security. Given that human populations can adapt their behaviour to a wide range of climatic and environmental conditions, it is essential that we understand the degree to which human choices in the past, present and future are resilient and sustainable in the face of variable weather conditions, and when confronted with abrupt events of climate change.TWORAINS will investigat",{"id":1092,"funder":7,"programme":8,"title":1093,"piName":10,"institution":719,"country":20,"year":13,"amount":10,"abstract":1094},"cordis-european-research-council-award-648381","Fundamental nuclear properties measured with laser spectroscopy","The prime research theme of this project is the study of short-lived exotic nuclei with laser spectroscopy. Over the next 5 years my team will study the role of three-nucleon forces and their associated influence on nuclear structure and the limits of nuclear existence. This work will investigate the interplay between tensor and central forces and the associated effect on quantum shells in exotic nuclear systems. This proposal will study how the shape of the nucleus is modified at the limits of ",{"id":1096,"funder":7,"programme":8,"title":1097,"piName":10,"institution":1098,"country":508,"year":13,"amount":675,"abstract":1099},"cordis-european-research-council-award-647274","Glia-derived factors in innate lymphoid cell sensing and intestinal defence","FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD","The interplay between intestinal microbes and immune cells ensures vital functions of the organism. However, inadequate host-microbe relationships lead to inflammatory diseases that are major public health concerns.Innate lymphoid cells (ILC) are an emergent family of effectors abundantly present at mucosal sites.  Group 3 ILC (ILC3) produce pro-inflammatory cytokines and regulate mucosal homeostasis, anti-microbial defence and adaptive immune responses.ILC development and function have been wid",200,{"programme":8,"total":1102,"withPiName":1103,"firstYear":1104,"lastYear":1105,"countryCount":1106,"perYear":1107,"topInstitutions":1147,"topCountries":1216},4499,349,2014,2027,45,[1108,1110,1112,1115,1118,1121,1124,1127,1130,1133,1136,1139,1142,1145],{"year":1104,"count":1109},303,{"year":13,"count":1111},335,{"year":1113,"count":1114},2016,322,{"year":1116,"count":1117},2017,327,{"year":1119,"count":1120},2018,403,{"year":1122,"count":1123},2019,300,{"year":1125,"count":1126},2020,277,{"year":1128,"count":1129},2021,321,{"year":1131,"count":1132},2022,364,{"year":1134,"count":1135},2023,359,{"year":1137,"count":1138},2024,366,{"year":1140,"count":1141},2025,375,{"year":1143,"count":1144},2026,416,{"year":1105,"count":1146},31,[1148,1151,1154,1157,1160,1163,1166,1168,1170,1173,1175,1178,1181,1183,1185,1188,1191,1194,1197,1200,1202,1205,1208,1211,1214],{"name":1149,"count":1150},"Centre National de la Recherche Scientifique CNRS",229,{"name":1152,"count":1153},"University of Oxford",89,{"name":1155,"count":1156},"Weizmann Institute of Science",78,{"name":1158,"count":1159},"University of Cambridge",77,{"name":1161,"count":1162},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",63,{"name":1164,"count":1165},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",55,{"name":1167,"count":1165},"Institut National de la Sante Et de la Recherche Medicale",{"name":1169,"count":1165},"Kobenhavns Universitet",{"name":1171,"count":1172},"Universiteit Utrecht",51,{"name":1174,"count":1172},"University College London",{"name":1176,"count":1177},"Tel Aviv University",49,{"name":1179,"count":1180},"The Hebrew University of Jerusalem",43,{"name":1182,"count":1180},"Universiteit Gent",{"name":1184,"count":1180},"Universiteit van Amsterdam",{"name":1186,"count":1187},"Ludwig-Maximilians-Universitaet Muenchen",42,{"name":1189,"count":1190},"Technische Universitaet Muenchen",41,{"name":1192,"count":1193},"Eidgenoessische Technische Hochschule Zuerich",40,{"name":1195,"count":1196},"Universitat Wien",39,{"name":1198,"count":1199},"Helsingin Yliopisto",38,{"name":1201,"count":1199},"Technische Universiteit Delft",{"name":1203,"count":1204},"Katholieke Universiteit Leuven",37,{"name":1206,"count":1207},"Universitetet I Oslo",36,{"name":1209,"count":1210},"École Polytechnique Fédérale de Lausanne",34,{"name":1212,"count":1213},"The University of Edinburgh",32,{"name":1215,"count":1146},"Lunds Universitet",[1217,1219,1221,1223,1225,1227,1229,1231,1232,1234,1236,1238,1240,1242,1244,1246,1248,1251,1252,1254,1256,1259,1262,1265,1268],{"name":52,"count":1218},810,{"name":20,"count":1220},559,{"name":32,"count":1222},490,{"name":183,"count":1224},428,{"name":59,"count":1226},315,{"name":158,"count":1228},267,{"name":613,"count":1230},219,{"name":12,"count":1100},{"name":756,"count":1233},170,{"name":208,"count":1235},166,{"name":743,"count":1237},146,{"name":90,"count":1239},127,{"name":72,"count":1241},94,{"name":479,"count":1243},85,{"name":45,"count":1245},82,{"name":508,"count":1247},68,{"name":1249,"count":1250},"GB",47,{"name":749,"count":1207},{"name":1030,"count":1253},24,{"name":65,"count":1255},22,{"name":1257,"count":1258},"US",21,{"name":1260,"count":1261},"PL",20,{"name":1263,"count":1264},"TR",14,{"name":1266,"count":1267},"LU",13,{"name":1269,"count":1270},"EE",8]