[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-consolidator-grant-2016":3,"awarded-stats-erc-consolidator-grant":1098},{"awarded":4,"total":1097},[5,16,21,28,35,42,48,53,58,65,70,75,80,85,90,97,103,108,113,117,122,128,133,139,145,151,156,162,168,174,179,183,188,193,198,203,208,213,218,224,228,233,238,244,249,254,259,263,268,273,278,283,288,293,298,304,309,314,319,325,331,337,341,348,353,359,364,369,374,379,386,392,399,405,411,416,421,428,434,440,446,452,458,464,470,475,480,484,491,497,501,506,511,516,521,526,531,536,541,547,553,559,565,570,576,582,589,596,601,606,612,618,624,630,635,641,646,651,657,662,668,673,679,684,689,695,701,707,713,719,725,731,737,742,748,755,760,766,771,776,780,784,790,795,801,807,812,817,822,828,834,838,843,848,854,859,864,870,875,882,887,893,898,902,907,912,916,922,926,931,936,941,946,952,956,961,966,972,976,982,988,994,999,1005,1010,1016,1022,1027,1032,1037,1042,1047,1052,1057,1062,1068,1073,1079,1084,1091],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-647696","European Research Council","ERC Consolidator Grant","Distinctive characterization of regulatory plasma cells and pro-inflammatory B cells in immunity: their origins, molecular properties, and cellular fates.",null,"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","FR",2016,"€1,999,375","B cells can act both as negative regulators and as drivers of immunity through the production of cytokines. Through secretion of interleukin (IL)-10 B cells inhibited immunity in autoimmune and infectious diseases. For instance, IL-10 from B cells drove complete recovery from disease in experimental autoimmune encephalomyelitis (EAE), the primary animal model for multiple sclerosis (MS), while a lack of IL-10 production by B cells resulted in a severe chronic EAE. B cells can also suppress immun",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":11,"country":12,"year":13,"amount":19,"abstract":20},"cordis-european-research-council-award-682345","NEUROBIOLOGY OF EPILEPSY GENES","€1,998,760","Ion channel genes have long been linked to Mendelian focal epilepsies, but my recent finding of frequent mutations in DEPDC5 opens completely new perspectives. DEPDC5 is an inhibitor of the mTORC1 (mammalian target of rapamycin) signaling pathway, the master regulator of cell proliferation and growth. Mutations of this gene are found in a wide spectrum of focal epilepsy syndromes, with or without cortical malformations. I propose to examine the links between DEPDC5 and the mTORC1 pathway in cort",{"id":22,"funder":7,"programme":8,"title":23,"piName":10,"institution":24,"country":25,"year":13,"amount":26,"abstract":27},"cordis-european-research-council-award-683305","RNA-protein Nanostructures for Synthetic Biology","AARHUS UNIVERSITET","DK","€1,999,935","Synthetic biology aims at re-engineering organisms for practical applications by designing novel biomolecular components, networks, and pathways. The field is expected to lead to cheaper drugs, sustainable fuel production, efficient diagnosis and targeted therapies for diseases. However, a major obstacle to achieve these goals is our limited ability to rationally design biomolecular structure and function. By contrast, the field of DNA nanotechnology has so far demonstrated an unprecedented abil",{"id":29,"funder":7,"programme":8,"title":30,"piName":10,"institution":31,"country":32,"year":13,"amount":33,"abstract":34},"cordis-european-research-council-award-681838","Moduli of Crystals and K3 Surfaces","TECHNISCHE UNIVERSITAET MUENCHEN","DE","€1,328,710","Algebraic geometry deals with algebraic varieties, that is, systems of polynomial equations and their geometric interpretation. Its ultimate goal is the classification of all algebraic varieties. For a detailed understanding, one has to construct their moduli spaces, and eventually study them over the integers, that is, in the arithmetic situation. So far, the best results are available for curves and Abelian varieties.To go beyond the aforementioned classes, I want to study arithmetic moduli sp",{"id":36,"funder":7,"programme":8,"title":37,"piName":10,"institution":38,"country":39,"year":13,"amount":40,"abstract":41},"cordis-european-research-council-award-681285","a Theoretical chemistry Approach to tiME-resolved molecular Plasmonics","UNIVERSITA DEGLI STUDI DI PADOVA","IT","€1,432,890","Ultrafast spectroscopy is a powerful tool able to disclose the atomistic real-time motion picture of the basic chemical events behind technology and Life, such as catalytic reactions or photosynthetic light harvesting. Nowadays, by cleverly harnessing the interaction of the studied molecules with plasmons (collective electron excitations supported, e.g., by metal nanoparticles) it is becoming possible to focus these investigations on specific nanoscopic regions, such as a portion of a catalytic ",{"id":43,"funder":7,"programme":8,"title":44,"piName":10,"institution":45,"country":39,"year":13,"amount":46,"abstract":47},"cordis-european-research-council-award-681379","Ultra-Short Pulse laser Resonators IN the Terahertz","CONSIGLIO NAZIONALE DELLE RICERCHE","€1,990,011","Ultra-short light pulses with large instantaneous intensities can probe light-matter interaction phenomena, capture snapshots of molecular dynamics and drive high-speed communications. In a semiconductor laser, mode-locking is the primary way to generate ultrafast signals. Despite the intriguing perspectives, operation at Terahertz (THz) frequencies is facing fundamental limitations: engineering ultrafast THz semiconductor lasers from scratch or finding an integrated technology to shorten THz li",{"id":49,"funder":7,"programme":8,"title":50,"piName":10,"institution":45,"country":39,"year":13,"amount":51,"abstract":52},"cordis-european-research-council-award-681597","Modeling microgels: from microscopic design to macroscopic description","€1,314,375","Soft matter provides the ideal playground for exploring physical phenomena that have no counterpart in atomic and molecular systems. A continuous progress in particle synthesis has provided a rich variety of soft, polymeric colloids, which are highly interpenetrable and can reach ultra-dense, jammed states. Such colloids offer exquisite control of material properties through a change in their internal architecture. Among this new generation of soft particles, microgels – colloidal-scale particle",{"id":54,"funder":7,"programme":8,"title":55,"piName":10,"institution":45,"country":39,"year":13,"amount":56,"abstract":57},"cordis-european-research-council-award-682157","4-Dimensional printing for adaptive optoelectronic components","€1,993,908","This project aims at developing four-dimensional printing of new adaptive systems, namely printing of complex, three-dimensional polymer objects embedding functional compounds and able to change or adapt their physical properties responding to environmental stimuli. Additive manufacturing of three-dimensional objects relies on depositing or curing materials in a layer-by-layer fashion, starting from computer assisted design. These technologies have rapidly evolved from laboratory research to com",{"id":59,"funder":7,"programme":8,"title":60,"piName":10,"institution":61,"country":62,"year":13,"amount":63,"abstract":64},"cordis-european-research-council-award-681337","Cities in Global Financial Networks: Financial and Business Services and Development in the 21st Century","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","UK","€1,929,306","Financial and business services (FABS), including law, accounting, and business consulting, have been one of the most dynamic sectors of the world economy, with a fivefold rise in real value added since 1980. Although FABS are central to the processes of globalisation, financialisation, urbanisation and development, our understanding of the sector in the context of tumultuous changes of the early 21st century is partial. How have the FABS firms and centres been affected by the global financial c",{"id":66,"funder":7,"programme":8,"title":67,"piName":10,"institution":61,"country":62,"year":13,"amount":68,"abstract":69},"cordis-european-research-council-award-681746","A Probe of the Periodic Elements for Life in the Sea","€2,000,000","Chemical elements are the building blocks of life. The major elements, C, H. O, N, P, S are easily recognised as essential nutrients, but their use by life relies on metalloproteins. The identity of the metal centres of these metalloproteins and even the broader palette of trace elements fundamental to life are remarkably poorly known. Whole genomes remain opaque to decoding of this bioinorganic dimension, and optimal trace element concentrations for physiological function. Defining the elementa",{"id":71,"funder":7,"programme":8,"title":72,"piName":10,"institution":61,"country":62,"year":13,"amount":73,"abstract":74},"cordis-european-research-council-award-681884","Travel, Transculturality and Identity in England, c.1550 – 1700","€1,998,519","The central research question this project will pose is: how did mobility in the great age of travel and discovery (c.1550–1700) shape English perceptions of human identity based on cultural identification and difference? The role of those marked by transcultural mobility was central to this period. Our current world is all too familiar with the concepts that surfaced or evolved as a result: ‘foreigners’, ‘strangers’, ‘aliens’, ‘converts’, ‘exiles’, or even ‘translators’, ‘ambassadors’ and ‘go-b",{"id":76,"funder":7,"programme":8,"title":77,"piName":10,"institution":61,"country":62,"year":13,"amount":78,"abstract":79},"cordis-european-research-council-award-681657","Comparing the Copperbelt: Political Culture and Knowledge Production in Central Africa","€1,599,661","This project provides the first comparative historical analysis – local, national and transnational - of the Central African copperbelt. This globally strategic mineral region is central to the history of two nation-states (Zambia and Democratic Republic of Congo (DRC)), as well as wider debates about the role of mineral wealth in development. The project has three interrelated and comparative objectives. First, it will examine the copperbelt as a single region divided by a (post-)colonial borde",{"id":81,"funder":7,"programme":8,"title":82,"piName":10,"institution":83,"country":12,"year":13,"amount":10,"abstract":84},"cordis-european-research-council-award-681814","Cultural Expertise in Europe: What is it useful for?","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","Respect for diversity has been at the forefront of political accession to the European Union since 1993 and socio-legal scholarship has developed articulated reflections on the accommodation of ethnic and religious minorities in Europe. Country-experts have been instructed with increasing frequency in judicial and pre-judicial proceedings involving members of diasporic communities. In some common law countries the role of the expert witness has expanded to systematically assist the judge when li",{"id":86,"funder":7,"programme":8,"title":87,"piName":10,"institution":61,"country":62,"year":13,"amount":88,"abstract":89},"cordis-european-research-council-award-682608","Higgs bundles: Supersymmetric Gauge Theories and Geometry","€1,794,562","String theory provides a unified description of particle physics and gravity, within a consistent theory of quantum gravity. The goal of this research is to develop both the phenomenological implications as well as conceptual foundations of string theory and its non-perturbative completions, M- and F-theory. Both, seemingly independent, questions are deeply connected to a mathematical structure, the Higgs bundle, which characterizes supersymmetric vacua of dimensionally reduced gauge theories, a",{"id":91,"funder":7,"programme":8,"title":92,"piName":10,"institution":93,"country":94,"year":13,"amount":95,"abstract":96},"cordis-european-research-council-award-647900","New approaches to long-standing questions: adaptation in Drosophila","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","ES","€2,392,521","Understanding how organisms adapt to their environments is a long-standing problem in Biology with far-reaching implications: adaptation affects the ability of species to survive in changing environments, host-pathogen interactions, and resistance to pesticides and drugs. Despite recent progress, adaptation is to date a poorly understood process largely due to limitations of current approaches that focus (i) on a priori candidate genes, (ii) on signals of selection at the DNA level without funct",{"id":98,"funder":7,"programme":8,"title":99,"piName":10,"institution":100,"country":62,"year":13,"amount":101,"abstract":102},"cordis-european-research-council-award-681422","Metacognition of Concepts","UNIVERSITY OF LONDON","€1,955,270","This project will investigate the thoughts and feelings that accompany the use of concepts. Concepts lie at the heart of the extraordinary power of the human mind. They are the building blocks of thought, the tools with which we think. Like physical tools, they can be more or less dependable, more or less fit for purpose: e.g. for most people GENE feels like a better concept than MEME. We have an intuitive sense of how dependable a concept is, which is crucial when we decide whether to rely on t",{"id":104,"funder":7,"programme":8,"title":105,"piName":10,"institution":61,"country":62,"year":13,"amount":106,"abstract":107},"cordis-european-research-council-award-647678","Combinatorial Construction","€1,706,729","Combinatorial Construction is a mathematical challenge with many applications. Examples include the construction of networks that are very sparse but highly connected, or codes that can correct many transmission errors with little overhead in communication costs. For a general class of combinatorial objects, and some desirable property, the fundamental question in Combinatorial Construction is to demonstrate the existence of an object with the property, preferably via an explicit algorithmic con",{"id":109,"funder":7,"programme":8,"title":110,"piName":10,"institution":61,"country":62,"year":13,"amount":111,"abstract":112},"cordis-european-research-council-award-682501","Vision-based Guidance and Control in Birds, with Applications to Autonomous Unmanned Aircraft","€2,492,266","Birds have been called “une aile guidée par un oeil”, and whilst they possess many senses besides vision, their wings are indeed guided largely by their eyes. Nevertheless, we know surprisingly little of how birds use vision to guide their flight, and almost nothing of the underlying guidance and control laws. This is an extraordinary omission, and unfortunate given the importance that vision is poised to assume in autonomous unmanned aircraft. With good reason, the law still requires a human e",{"id":114,"funder":7,"programme":8,"title":115,"piName":10,"institution":83,"country":12,"year":13,"amount":10,"abstract":116},"cordis-european-research-council-award-648161","Integrating photochemistry in nanoconfined carbon-based porous materials in technological processes","The aim of this proposal is to exploit the potentialities of confined pore spaces in technological processes related to applied photochemistry for gas sensing, energy conversion and environmental protection. I will focus on new light responsive nanoporous carbons which characteristics can be tailored at two levels (pore void at the nanometric scale and surface functionalization) during the synthesis to modulate their selectivity towards a given molecule (i.e. gas sensing) or efficiency in a give",{"id":118,"funder":7,"programme":8,"title":119,"piName":10,"institution":93,"country":94,"year":13,"amount":120,"abstract":121},"cordis-european-research-council-award-681299","Unfolding the Mechanism of Chromosome Cohesion and Condensation using Single-Molecule Biophysical Approaches","€1,894,999","The global folding of the chromosome is mediated by Structural Maintenance of Chromosome (SMC) proteins, which stabilize the higher-order chromatin architecture by bringing distant DNA sequences together. Despite over a decade of work on these systems, their mechanism remains unknown, largely because of difficulty in re-capitulating physiological DNA binding and condensation in vitro. Moreover, traditional biochemical approaches are poorly suited for the study of processes that are fundamentally",{"id":123,"funder":7,"programme":8,"title":124,"piName":10,"institution":125,"country":126,"year":13,"amount":68,"abstract":127},"cordis-european-research-council-award-682782","From bond breaking to material failure in soft polymer networks","WAGENINGEN UNIVERSITY","NL","The microscopic mechanisms that lead to mechanical failure of soft polymer materials are still poorly understood. The main reason for this is a lack of experimental tools to prepare well-controlled model systems and to observe the failure process in real time at the microscopic scale. Here, I propose to fill this gap by taking a multidisciplinary approach that combines innovative chemical tools with state-of-the art physical experiments and modelling. Previous work in my group has led to the dev",{"id":129,"funder":7,"programme":8,"title":130,"piName":10,"institution":125,"country":126,"year":13,"amount":131,"abstract":132},"cordis-european-research-council-award-682444","Electro-motion for the sustainable recovery of high-value nutrients from waste water","€1,950,000","Current water treatment technologies are mainly aimed to improve the quality of water. High-value nutrients, like nitrate and phosphate ions, often remain present in waste streams. Electro-driven separation processes offer a sustainable way to recover these nutrients. Ion-selective polymer membranes are a strong candidate to achieve selectivity in such processes.The aim of E-motion is to chemically modify porous electrodes with membranes to introduce selectivity in electro-driven separation proc",{"id":134,"funder":7,"programme":8,"title":135,"piName":10,"institution":136,"country":32,"year":13,"amount":137,"abstract":138},"cordis-european-research-council-award-682496","The role of RNA in centromere biology and genome integrity","KARLSRUHER INSTITUT FUER TECHNOLOGIE","€1,896,250","One of the most astonishing processes in the life of a cell is the division into two daughter cells. Such a highly organized process would presumably be regulated tightly by the underlying centromeric DNA sequence; however, the sites of chromosome attachment to the microtubule spindle are regulated by epigenetic mechanisms. The best-characterized epigenetic mark for centromeres is the histone H3-variant CENP-A, which replaces H3 in some of the nucleosomes within centromeric chromatin. Centromere",{"id":140,"funder":7,"programme":8,"title":141,"piName":10,"institution":142,"country":143,"year":13,"amount":10,"abstract":144},"cordis-european-research-council-award-682379","Hybrid Volumetric Optoacoustic-Ultrasound Tomography for Noninvasive Large-Scale Recording of Brain Activity with High Spatiotemporal Resolution","UNIVERSITAT ZURICH","CH","Non-invasive observation of fast spatiotemporal activity patterns of large neural populations distributed over entire brains is a longstanding goal of neuroscience. Not only would such abilities significantly promote our knowledge on brain function and its pathophysiology but they are also expected to accelerate development of novel therapies targeting neurological and neuropsychiatric disorders. The progress is hampered by the limited capacity of state-of-the-art functional neuroimaging tools, ",{"id":146,"funder":7,"programme":8,"title":147,"piName":10,"institution":148,"country":32,"year":13,"amount":149,"abstract":150},"cordis-european-research-council-award-683000","Cellular and molecular mechanisms of metabolic immune activation triggering non-alcoholic steatohepatitis (NASH) and HCC","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","€1,995,860","Overweight and metabolic syndrome are reaching pandemic dimensions in industrialized countries and are rising in developing countries. Clinically these diseases can manifest in non-alcoholic fatty liver disease (NAFLD), the most frequent liver disease world-wide. A significant number of NAFLD patients develop non-alcoholic steatohepatitis (NASH), fibrosis and hepatocellular carcinoma (HCC), making NASH-driven HCC the most rapidly increasing cancer in the USA, with a similar trend in Europe. Whil",{"id":152,"funder":7,"programme":8,"title":153,"piName":10,"institution":154,"country":94,"year":13,"amount":10,"abstract":155},"cordis-european-research-council-award-682080","Intuitive editing of visual appearance from real-world datasets","UNIVERSIDAD DE ZARAGOZA","Computer-generated imagery is now ubiquitous in our society, spanning fields such as games and movies, architecture, engineering, or virtual prototyping, while also helping create novel ones such as computational materials. With the increase in computational power and the improvement of acquisition techniques, there has been a paradigm shift in the field towards data-driven techniques, which has yielded an unprecedented level of realism in visual appearance. Unfortunately, this leads to a series",{"id":157,"funder":7,"programme":8,"title":158,"piName":10,"institution":159,"country":12,"year":13,"amount":160,"abstract":161},"cordis-european-research-council-award-683032","An end-to-end verification architecture for building Certified Implementations of Robust,  Cryptographically Secure web applications","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","€1,885,248","The security of modern web applications depends on a variety of critical components including cryptographic libraries, Transport Layer Security (TLS), browser security mechanisms, and single sign-on protocols. Although these components are widely used, their security guarantees remain poorly understood, leading to subtle bugs and frequent attacks.Rather than fixing one attack at a time, we advocate the use of formal security verification to identify and eliminate entire classes of vulnerabilitie",{"id":163,"funder":7,"programme":8,"title":164,"piName":10,"institution":165,"country":32,"year":13,"amount":166,"abstract":167},"cordis-european-research-council-award-681208","Strongly interacting Rydberg slow light polaritons","UNIVERSITY OF STUTTGART","€1,505,750","A fundamental property of optical photons is their extremely weak interactions, which can be ignored for all practical purposes and applications. This phenomena forms the basis for our understanding of light and is at the heart for the rich variety of tools available to manipulate and control optical beams. On the other hand, a controlled and strong interaction between individual photons would be ideal to generate non-classical states of light, prepare correlated quantum states of photons, and h",{"id":169,"funder":7,"programme":8,"title":170,"piName":10,"institution":171,"country":32,"year":13,"amount":172,"abstract":173},"cordis-european-research-council-award-683008","Amplifying Human Perception Through Interactive Digital Technologies","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€1,925,250","Current technical sensor systems offer capabilities that are superior to human perception. Cameras can capture a spectrum that is wider than visible light, high-speed cameras can show movements that are invisible to the human eye, and directional microphones can pick up sounds at long distances. The vision of this project is to lay a foundation for the creation of digital technologies that provide novel sensory experiences and new perceptual capabilities for humans that are natural and intuitive",{"id":175,"funder":7,"programme":8,"title":176,"piName":10,"institution":83,"country":12,"year":13,"amount":177,"abstract":178},"cordis-european-research-council-award-682778","New insight into the origin of the Earth, its bulk composition and its early evolution","€2,200,000","The main geochemical features of the mantles of terrestrial planets and asteroids can be attributed to differentiation events that occurred during or shortly after the formation of the Solar System. Numerous questions remain regarding the Earth’s bulk composition and the most likely scenario for its evolution prior to the last major differentiation event caused by a giant impact leading to the formation of the Moon. The aim of this five-year project is to evaluate the state-of-the-art models of ",{"id":180,"funder":7,"programme":8,"title":181,"piName":10,"institution":83,"country":12,"year":13,"amount":10,"abstract":182},"cordis-european-research-council-award-681415","Promoting, Patronising and Practising the Arts in Roman Aristocratic Families (1644-1740). The  Contribution of Roman Family Archives to the History of Performing Arts","Rome, centre of the Catholic Church and capital of the Papal States, strewn with churches and religious institutions, was also, in the 17th and 18th centuries, the scene of intense conflicts and rivalries between some twenty leading aristocratic families, highly adept at organising musical, theatrical and choreographic performances to display their political sympathies. The artistic life that animated the palaces and country villas of this elite has been far less studied than that of the papal c",{"id":184,"funder":7,"programme":8,"title":185,"piName":10,"institution":83,"country":12,"year":13,"amount":186,"abstract":187},"cordis-european-research-council-award-647916","Evolution of viral codon usage preferences:manipulation of translation accuracy and evasion of immune response","€1,997,100","Fidelity during information transfer is essential for life, but it pays to be unfaithful if it provides an evolutionary advantage. The immune system continuously generates diversity to put up with recurrent pathogen challenges, and many viruses, in its turn, have evolved mechanisms to generate diversity to evade immune restrictions, even at the cost of enduring high mutation rates.Synonymous codons are not used at random and are not translated with similar efficiency. A large proportion of virus",{"id":189,"funder":7,"programme":8,"title":190,"piName":10,"institution":83,"country":12,"year":13,"amount":191,"abstract":192},"cordis-european-research-council-award-682955","Bio-inspired Spin-Torque Computing Architectures","€1,907,767","In the bioSPINspired project, I propose to use my experience and skills in spintronics, non-linear dynamics and neuromorphic nanodevices to realize bio-inspired spin torque computing architectures. I will develop a bottom-up approach to build spintronic data processing systems that perform low power ‘cognitive’ tasks on-chip and could ultimately complement our traditional microprocessors. I will start by showing that spin torque nanodevices, which are multi-functional and tunable nonlinear dynam",{"id":194,"funder":7,"programme":8,"title":195,"piName":10,"institution":196,"country":12,"year":13,"amount":10,"abstract":197},"cordis-european-research-council-award-682895","Dynamic Nuclear Polarization at ultra-fast sample spinning and ultra-low temperature","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","The goal of the project is to develop a new hyperpolarization approach called Magic Angle Spinning Dynamic Nuclear Polarization (MAS-DNP) to reach levels of sensitivity and resolution that have never been achieved, in order to tackle highly relevant chemical and biological questions that remain unanswered so far. Firstly this will provide major advances in NMR crystallography (solving 3D structures by NMR) by showing that distance measurements between nuclei (13C, 15N, etc.) as well as 17O quadr",{"id":199,"funder":7,"programme":8,"title":200,"piName":10,"institution":83,"country":12,"year":13,"amount":201,"abstract":202},"cordis-european-research-council-award-682001","Monitoring bone healing around endosseous implants: from multiscale modeling to the patient’s bed","€1,992,154","Implants are often employed in orthopaedic and dental surgeries. However, risks of failure, which are difficult to anticipate, are still experienced and may have dramatic consequences. Failures are due to degraded bone remodeling at the bone-implant interface, a multiscale phenomenon of an interdisciplinary nature which remains poorly understood. The objective of BoneImplant is to provide a better understanding of the multiscale and multitime mechanisms at work at the bone-implant interface. To ",{"id":204,"funder":7,"programme":8,"title":205,"piName":10,"institution":83,"country":12,"year":13,"amount":206,"abstract":207},"cordis-european-research-council-award-681978","Invasive cognitive brain computer interfaces to enhance and restore attention: proof of concept and underlying cortical mechanisms.","€1,997,748","The present project focuses on a barely scratched aspect of invasive cognitive brain-computer interfaces (cBCIs), i.e. closed-loop invasive cBCIs to augment and restore attentional functions. Its aim is to achieve an efficient enhanced cognition protocol both in the healthy brain and in the damaged brain and to study the local and global plasticity mechanisms underlying these effects. The project relies on the unique methodological combination of multi-electrode multisite intracortical recording",{"id":209,"funder":7,"programme":8,"title":210,"piName":10,"institution":211,"country":62,"year":13,"amount":10,"abstract":212},"cordis-european-research-council-award-682156","Financial Decision Making with Endogenous Information Acquisition","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","Are financial markets informationally efficient? Are some economic agents more informed than others? What is the impact of such heterogeneity on asset prices? These questions, of great economic significance, have permeated academic and business circles over the last few decades. Despite significant progress on the theoretical and empirical fronts relatively little is known about how information is endogenously acquired and processed in markets by agents with differential access to information an",{"id":214,"funder":7,"programme":8,"title":215,"piName":10,"institution":83,"country":12,"year":13,"amount":216,"abstract":217},"cordis-european-research-council-award-681605","The makeup of the modern horse: a history of the biological changes introduced by human management","€1,999,555","The horse provided us with rapid transportation, an almost unrivaled secondary product that tremendously impacted the politico-economical trajectory of our societies, revolutionizing the circulation of ideas, people, languages, religions and communication. Horse chariotry and cavalry also changed warfare and beyond the battlefield new equestrian technologies have stimulated agricultural productivity. However, the 5,500 year long history of horse domestication and management, which transformed th",{"id":219,"funder":7,"programme":8,"title":220,"piName":10,"institution":221,"country":62,"year":13,"amount":222,"abstract":223},"cordis-european-research-council-award-681579","Bayesian Peer Influence: Group Beliefs, Polarisation and Segregation","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","€1,662,942","The objective of this research agenda is to provide a new framework to model and analyze dynamics of group beliefs, in order to study phenomena such as group polarization, segregation and inter-group discrimination. We introduce a simple new heuristic, the Bayesian Peer Influence heuristic (BPI), which is based on rational foundations and captures how individuals are influenced by others' beliefs. We will explore the theoretical properties of this heuristic, and apply the model to analyze the im",{"id":225,"funder":7,"programme":8,"title":226,"piName":10,"institution":221,"country":62,"year":13,"amount":10,"abstract":227},"cordis-european-research-council-award-681664","Research on Macroeconomic Fluctuations and Trade","The proposal is divided into three strands whose main goals are to i) study macroeconomic fluctuations, ii) identify the mechanisms that drive and propagate these fluctuations, and iii) use the empirical findings to inform and formulate models that can be used for quantitative policy and positive analysis.The first strand will exploit a new dataset to study housing markets during the build-up and aftermath of the crisis. We will document a robust pattern of history dependence in housing markets ",{"id":229,"funder":7,"programme":8,"title":230,"piName":10,"institution":221,"country":62,"year":13,"amount":231,"abstract":232},"cordis-european-research-council-award-682288","New perspectives on inflation","€1,568,276","The research in this proposal will contribute to our knowledge of the dynamics and effects of inflation through the perspective of risk-adjusted inflation and valuation formulas. The goal is to provide new perspectives on inflation and its impact onresource constraints.The first step in this work is to collect new data on inflation options and use them to construct marginal densities for risk-neutral inflation at different horizons. Because there are data for both cumulative and annual inflation",{"id":234,"funder":7,"programme":8,"title":235,"piName":10,"institution":221,"country":62,"year":13,"amount":236,"abstract":237},"cordis-european-research-council-award-681696","Designing Effective Public Policies","€1,294,699","This proposal outlines a number of projects in public economics, with links to other fields such as macro, real estate, labor, and gender economics. The projects evolve around several large administrative datasets from the UK and Denmark, and they advance approaches and methodologies that have recently been developed in public economics into new areas. There is a strong public policy focus running through the proposal, including tax policy, transfer policy, family policy, and indirectly monetary",{"id":239,"funder":7,"programme":8,"title":240,"piName":10,"institution":241,"country":12,"year":13,"amount":242,"abstract":243},"cordis-european-research-council-award-648480","Behavioral and neural determinants of metacognition and self-awareness in human adults and infants","ECOLE NORMALE SUPERIEURE","€1,981,338","Proposal summary. Understanding the psychological and neurobiological determinants of consciousness is fundamental. Yet, the main trend focusing on how the front of the brain (prefrontal cortex) interacts with the back (sensory cortex) for accessing perceptual contents limits our understanding of the information coding schemas underlying consciousness. Here, we explore these informational properties in adults and infants from 3 novel perspectives: sleep, self-consciousness and metacognition. Fir",{"id":245,"funder":7,"programme":8,"title":246,"piName":10,"institution":211,"country":62,"year":13,"amount":247,"abstract":248},"cordis-european-research-council-award-682587","Reducing the Burden of Smouldering Megafires: an Earth-Scale Challenge","€1,958,900","Smouldering megafires are the largest and longest-burning fires on Earth. They destroy essential peatland ecosystems, and are responsible for 15% of annual global greenhouse gas emissions. This is the same amount attributed to the whole of the European Union, and yet it is not accounted for in global carbon budgets. Peat fires also induce surges of respiratory emergencies in the population and disrupt shipping and aviation routes for long periods, weeks even months. The ambition of HAZE is to ad",{"id":250,"funder":7,"programme":8,"title":251,"piName":10,"institution":83,"country":12,"year":13,"amount":252,"abstract":253},"cordis-european-research-council-award-682819","The evolutionary significance of synonymous variations: Can codon usage preferences drive the propagation of antibiotic resistance?","€1,992,366","The intensive use of antibiotics provided an unprecedented improvement in infectious disease treatments but at the expense of creating ideal conditions for the selection of widespread resistance. Propagation of antibiotic resistances is favoured by horizontal gene transfer and by bacterial life in multispecies community. However, compositions of resistome and bacterial communities are often correlated, suggesting that propagation of resistances does not occur at random. This project will test th",{"id":255,"funder":7,"programme":8,"title":256,"piName":10,"institution":83,"country":12,"year":13,"amount":257,"abstract":258},"cordis-european-research-council-award-682032","Pushing ultrafast laser material processing into a new regime of plasma-controlled ablation","€1,996,581","Ultra-intense femtosecond laser pulses promise to become a fast, universal, predictable and green tool for material processing at micro and nanometric scale. The recent tremendous increase in commercially available femtosecond laser energy at high repetition rate opens a wealth of novel perspectives for mass production. But even at high energy, laser processing remains limited to high-speed scanning point by point removal of ultra-thin nanometric layers from the material surface. This is because",{"id":260,"funder":7,"programme":8,"title":261,"piName":10,"institution":83,"country":12,"year":13,"amount":10,"abstract":262},"cordis-european-research-council-award-681839","New paradigms for latent factor estimation","Data is often available in matrix form, in which columns are samples, and processing of such data often entails finding an approximate factorisation of the matrix in two factors. The first factor yields recurring patterns characteristic of the data. The second factor describes in which proportions each data sample is made of these patterns. Latent factor estimation (LFE) is the problem of finding such a factorisation, usually under given constraints. LFE appears under other domain-specific names",{"id":264,"funder":7,"programme":8,"title":265,"piName":10,"institution":211,"country":62,"year":13,"amount":266,"abstract":267},"cordis-european-research-council-award-682399","Time resolved X-ray probing of Matter under Extreme conditions","€1,996,316","The unique properties of a new type of X-ray source produced by a compact laser-plasma accelerator will be used to probe the ultra-fast dynamics of the electronic structure of matter under extreme conditions.The TeX-MEx project will study: 1) hot dense matter, such as that found at the centre of the Sun; 2) warm dense matter such as that found at the centre of Jupiter and 3) photo-ionized plasmas far from equilibrium such as is found in the exotic environment of an accretion disk surrounding a b",{"id":269,"funder":7,"programme":8,"title":270,"piName":10,"institution":211,"country":62,"year":13,"amount":271,"abstract":272},"cordis-european-research-council-award-682603","Gromov-Witten Theory: Mirror Symmetry, Birational Geometry, and the Classification of Fano Manifolds","€1,999,995","The classification of Fano manifolds is a long-standing and important open problem.  Fano manifolds are basic building blocks in geometry: they are `atomic pieces' of mathematical shapes.  We will take a radically new approach to Fano classification, combining Mirror Symmetry (a circle of ideas which originated in string theory) with new methods in geometry and massively-parallel computational algebra.  Our main geometric tool will be Gromov-Witten invariants.   The Gromov-Witten invariants of a",{"id":274,"funder":7,"programme":8,"title":275,"piName":10,"institution":83,"country":12,"year":13,"amount":276,"abstract":277},"cordis-european-research-council-award-682286","Bio-inspired electrONIC NOSE interfacing olfactory electrical biosensors and carbon NANOtubes","€1,926,870","The goal of this project is to develop an innovative biosensor for the non-invasive, painless and real-time detection of volatile biomarkers in the exhaled breath of patients. Volatile biomarkers have been identified for several diseases including cancers, diabetes, cystic fibrosis and neurodegeneration. A miniaturized system for fast and simple breath-analysis would not only improve the early detection of these pathologies but also enable point-of-care monitoring of patients either in medical i",{"id":279,"funder":7,"programme":8,"title":280,"piName":10,"institution":83,"country":12,"year":13,"amount":281,"abstract":282},"cordis-european-research-council-award-647455","Modulation of RNA-based regulatory processes by viruses","€1,998,291","Small and large non-coding RNAs are essential components at the heart of gene expression regulation. The past fifteen years have witnessed the emergence of a new field of research impacting diverse domains of biology. Among these, virology is no exception and discoveries such as the antiviral role of RNA silencing, virus-encoded microRNAs (miRNAs), or miRNA-based regulation of viruses have notably shifted our views of host-virus interactions. Although we know a lot about the mechanisms of action",{"id":284,"funder":7,"programme":8,"title":285,"piName":10,"institution":83,"country":12,"year":13,"amount":286,"abstract":287},"cordis-european-research-council-award-682367","Particle dynamics in the flow of complex suspensions","€1,971,750","Particle laden flows are ubiquitous in nature and industrial applications. Particle trajectories determine transport in porous media or biomedical conducts and effective suspension properties dictate flow behavior in food processing or biofluid flow. For a better control it is necessary to know how to predict these processes from the involved particle and flow properties.  However, current theory is not able to capture the complexity of the applications and experiments have been carried out on t",{"id":289,"funder":7,"programme":8,"title":290,"piName":10,"institution":83,"country":12,"year":13,"amount":291,"abstract":292},"cordis-european-research-council-award-683257","An Integrative Approach to Understanding Convergent Evolution in Ant-eating Mammals","€1,880,570","Despite its widespread occurrence across the tree of life, many questions still remain unanswered concerning the fascinating phenomenon of convergent evolution. Ant-eating mammals constitute a textbook example of morphological convergence with at least five independent origins in placentals (armadillos, anteaters, aardvarks, pangolins, and aardwolves). The large extent of convergent morphological evolution, the importance of molecular convergence, and the role of the host microbiome in diet adap",{"id":294,"funder":7,"programme":8,"title":295,"piName":10,"institution":83,"country":12,"year":13,"amount":296,"abstract":297},"cordis-european-research-council-award-681346","Reproducing EArthquakes in the Laboratory: Imaging, Speed and Mineralogy","€2,748,188","We propose a simple idea: to reproduce earthquakes in the laboratory. Because earthquakes are spectacular examples of uncontrollable catastrophes, the opportunity to study them under controlled conditions in the laboratory is unique and is, in fact, the only way to understand the details of the earthquake source physics.The aim of the project is interdisciplinary, at the frontiers between Rock Fracture Mechanics, Seismology, and Mineralogy.  Its ultimate goal is to improve, on the basis of integ",{"id":299,"funder":7,"programme":8,"title":300,"piName":10,"institution":301,"country":12,"year":13,"amount":302,"abstract":303},"cordis-european-research-council-award-681514","Exploiting light coherence in photoacoustic imaging","UNIVERSITE GRENOBLE ALPES","€2,116,290","Photoacoustic imaging is an emerging multi-wave imaging modality that couples light excitation to acoustic detection, via the photoacoustic effect (sound generation via light absorption). Photoacoustic imaging provides images of optical absorption (as opposed to optical scattering). In addition, as photoacoustic imaging relies on detecting ultrasound waves that are very weakly scattered in biological tissue, it provides acoustic-resolution images of optical absorption non-invasively at large dep",{"id":305,"funder":7,"programme":8,"title":306,"piName":10,"institution":83,"country":12,"year":13,"amount":307,"abstract":308},"cordis-european-research-council-award-682978","Extreme Ultraviolet Circular Time-Resolved Spectroscopy","€1,691,865","Chiral molecules exist as two forms, so-called enantiomers, which have essentially the same physical and chemical properties and can only be distinguished via their interaction with a chiral system, such as circularly polarized light. Many biological processes are chiral-sensitive and unraveling the dynamical aspects of chirality is of prime importance for chemistry, biology and pharmacology. Studying the ultrafast electron dynamics of chiral processes requires characterization techniques at the",{"id":310,"funder":7,"programme":8,"title":311,"piName":10,"institution":83,"country":12,"year":13,"amount":312,"abstract":313},"cordis-european-research-council-award-681484","Adaptive significance of Non Genetic Inheritance","€1,999,970","Our ability to predict adaptation and the response of populations to selection is limited. Solving this issue is a fundamental challenge of evolutionary ecology with implications for applied sciences such as conservation, and agronomy. Non genetic inheritance (NGI; e.g., ecological niche transmission) is suspected to play a foremost role in adaptive evolution but such hypothesis remains untested. Using quantitative genetics in wild plant populations, experimental evolution, and epigenetics, we w",{"id":315,"funder":7,"programme":8,"title":316,"piName":10,"institution":83,"country":12,"year":13,"amount":317,"abstract":318},"cordis-european-research-council-award-681835","Fluid dynamics of planetary cores: formation, heterogeneous convection and rotational dynamics","€1,992,602","Understanding the flows in planetary cores from their formation to their current dynamics is a tremendous interdisciplinary challenge. Beyond the challenge in fundamental fluid dynamics to understand these extraordinary flows involving turbulence, rotation and buoyancy at typical scales well beyond our day-to-day experience, a global knowledge of the involved processes is fundamental to a better understanding of the initial state of planets, of their thermal and orbital evolution, and of magneti",{"id":320,"funder":7,"programme":8,"title":321,"piName":10,"institution":322,"country":62,"year":13,"amount":323,"abstract":324},"cordis-european-research-council-award-681018","Constructing the Higher Education Student: a comparative study of six European countries","UNIVERSITY OF SURREY","€1,753,936","There are currently over 35 million students within Europe and yet, to date, we have no clear understanding of the extent to which understandings of ‘the student’ are shared. This project thus investigates how the contemporary higher education student is conceptualised and the extent to which this differs both within nation-states and across them. This is significant in terms of implicit (and sometimes explicit) assumptions that are made about common understandings of ‘the student’ across Europe",{"id":326,"funder":7,"programme":8,"title":327,"piName":10,"institution":328,"country":329,"year":13,"amount":10,"abstract":330},"cordis-european-research-council-award-683031","The Economics and Politics of Conservation","UNIVERSITETET I OSLO","NO","The UN’s approach to climate policy is to focus on national emission caps for greenhouse gases. Most of the economic theory on environmental agreements is also studying such a demand-side approach, even though it is well known that such an approach has several flaws, including carbon leakage and the incentive to free ride. Recent theory has suggested that a better approach may be to focus on the supply-side of the equation, rather than the demand-side. While this recent theory is promising, it i",{"id":332,"funder":7,"programme":8,"title":333,"piName":10,"institution":334,"country":39,"year":13,"amount":335,"abstract":336},"cordis-european-research-council-award-682629","Topology and symmetries in synthetic fermionic systems","UNIVERSITA DEGLI STUDI DI FIRENZE","€1,595,000","Topology and symmetry are two fundamental and intertwined concepts driving the behavior of fermionic systems in both condensed-matter and high-energy physics. The goal of the TOPSIM project is to address open problems concerning topological states of fermionic matter from an experimental point of view, by taking advantage of novel possibilities of quantum control on synthetic systems formed by ultracold neutral atoms. We will investigate the behavior of fermionic matter under strong gauge fields",{"id":338,"funder":7,"programme":8,"title":339,"piName":10,"institution":328,"country":329,"year":13,"amount":10,"abstract":340},"cordis-european-research-council-award-682462","ALMA – The key to the Sun’s coronal heating problem.","How are the outer layers of the Sun heated to temperatures in excess of a million kelvin?  A large number of heating mechanisms have been proposed to explain this so-called coronal heating problem, one of the fundamental questions in contemporary solar physics. It is clear that the required energy is transported from the solar interior through the chromosphere into the outer layers but it remains open by which physical mechanisms and how the provided energy is eventually dissipated. The key to s",{"id":342,"funder":7,"programme":8,"title":343,"piName":10,"institution":344,"country":345,"year":13,"amount":346,"abstract":347},"cordis-european-research-council-award-681544","3D Printing of Novel 2D Nanomaterials: Adding Advanced 2D Functionalities to Revolutionary Tailored 3D Manufacturing","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","IE","€2,499,942","My vision is to establish, within the framework of an ERC CoG, a multidisciplinary group which will work in concert towards pioneering the integration of novel 2-Dimensional nanomaterials with novel additive fabrication techniques to develop a unique class of energy storage devices.Batteries and supercapacitors are two very complementary types of energy storage devices. Batteries store much higher energy densities; supercapacitors, on the other hand, hold one tenth of the electricity per unit of",{"id":349,"funder":7,"programme":8,"title":350,"piName":10,"institution":344,"country":345,"year":13,"amount":351,"abstract":352},"cordis-european-research-council-award-683197","Western banks in Eastern Europe: New geographies of financialisation","€1,806,536","Financialisation, or the growing power of finance over societies and economies, is increasingly recognised as the key feature of contemporary capitalism. However, significant gaps in our understanding of this process remain. Indeed, despite growing recognition that financialisation is an inherently spatial process, a geographically-informed view of financialisation remains underdeveloped. In addition, and related to this, the extent and the ways in which post-socialist ‘transition’ societies in ",{"id":354,"funder":7,"programme":8,"title":355,"piName":10,"institution":356,"country":126,"year":13,"amount":357,"abstract":358},"cordis-european-research-council-award-648666","Collapse Of Atmospheric Turbulence","TECHNISCHE UNIVERSITEIT DELFT","€1,659,580","This project aims to predict the cessation of continuous turbulence in the evening boundary layer. The interaction between the lower atmosphere and the surface is studied in detail, as this plays a crucial role in the dynamics. Present generation forecasting models are incapable to predict whether or not turbulence will survive or collapse under cold conditions. In nature, both situations frequently occur and lead to completely different temperature signatures. As such, significant forecast erro",{"id":360,"funder":7,"programme":8,"title":361,"piName":10,"institution":356,"country":126,"year":13,"amount":362,"abstract":363},"cordis-european-research-council-award-682726","Engineering Quantum Error Correction","€1,786,563","This proposal will advance the theory of quantum error correction towards its application in real physical devices, in particular superconducting transmon qubit systems. The research will result in proposals for experiments: how to use physical qubits to redundantly represent logical quantum information and how error information can be obtained and classically processed. The research will consider novel ways of using transmon qubits to achieve a universal fault-tolerant surface code architecture",{"id":365,"funder":7,"programme":8,"title":366,"piName":10,"institution":38,"country":39,"year":13,"amount":367,"abstract":368},"cordis-european-research-council-award-681813","A seamless multi-scale model for contact, friction, and solid lubrication","€1,999,985","Friction and wear are liable for enormous losses in terms of energy and  resources in modern society. Costs related to unwanted friction in industrialised countries are estimated to be about 3% of the gross domestic product. Urgency is even greater nowadays as friction between micro-components has become the bottleneck of several applications for which miniaturisation is critical.Lubrication is a commonly adopted solution to reduce friction. Graphite is a broadly used solid lubricant for large s",{"id":370,"funder":7,"programme":8,"title":371,"piName":10,"institution":356,"country":126,"year":13,"amount":372,"abstract":373},"cordis-european-research-council-award-681476","Quantum Optomechanics in 3D","€1,999,594","Optomechanics is a field that aims to detect and control mechanical motion with light, ultimately at the quantum level. Experiments reaching the mechanical quantum ground state established optomechanics as a rapidly growing new field. Now that the quantum ground state has been reached, what is the next step?The current goal of the field is quantum superposition states of motion. An example of this is a mechanical “Schrodinger cat” state, in which a drum is in a quantum superposition of vibrating",{"id":375,"funder":7,"programme":8,"title":376,"piName":10,"institution":377,"country":32,"year":13,"amount":10,"abstract":378},"cordis-european-research-council-award-682383","Enabling Hydrogen-enriched burner technology for gas turbines through advanced measurement and simulation","DEUTSCHES ZENTRUM FUR LUFT - UND RAUMFAHRT EV","A major impediment to the economic viability of carbon-free renewable energy sources such as wind and solar power is an inability to effectively utilize the power they generate if it is not immediately needed. One option to address this is to use excess generator capacity during off-peak demand periods to produce hydrogen (H2), a high energy-content, carbon-free fuel that can be mixed with natural gas and distributed to end-users via existing natural gas pipeline infrastructure, where its energy",{"id":380,"funder":7,"programme":8,"title":381,"piName":10,"institution":382,"country":383,"year":13,"amount":384,"abstract":385},"cordis-european-research-council-award-682009","Memory in biological regulatory circuits","VIB VZW","BE","€1,959,844","The emergence of intelligence –the ability to remember and analyze data to make decisions– was a milestone in evolution. Intelligence and memory are usually associated with plastic neuronal connections in higher organisms. However, new discoveries hint that a rudimentary form of intelligence is rooted in networks that regulate gene expression in a wide range of organisms, including bacteria and yeasts. Specifically, we and others have shown that microbes show plastic behavioral responses to past",{"id":387,"funder":7,"programme":8,"title":388,"piName":10,"institution":389,"country":32,"year":13,"amount":390,"abstract":391},"cordis-european-research-council-award-681891","Multi-protein interaction kinetics by single molecule methods","ALBERT-LUDWIGS-UNIVERSITAET FREIBURG","€1,882,500","Objective of this proposal is to obtain a real time picture of how components of a multi-protein complex interact to perform complex regulated tasks, in particular to see how a protein system might be more than the sum of its components. In living organisms many proteins work in complexes to form multicomponent protein machines and to regulate cellular processes. The function of such multicomponent machines is usually addressed by dividing them into a collection of two state systems at equilibri",{"id":393,"funder":7,"programme":8,"title":394,"piName":10,"institution":395,"country":396,"year":13,"amount":397,"abstract":398},"cordis-european-research-council-award-681715","Host-virus chemical arms race during algal bloom in the ocean at a single cell resolution","WEIZMANN INSTITUTE OF SCIENCE","IL","€2,749,901","Phytoplankton blooms are ephemeral events of exceptionally high primary productivity that regulate the flux of carbon across marine food webs. The cosmopolitan coccolithophore Emiliania huxleyi (Haptophyta) is a unicellular eukaryotic alga responsible for the largest oceanic algal blooms covering thousands of square kilometers. These annual blooms are frequently terminated by a specific large dsDNA E. huxleyi virus (EhV). Despite the huge ecological importance of host-virus interactions, the abi",{"id":400,"funder":7,"programme":8,"title":401,"piName":10,"institution":402,"country":126,"year":13,"amount":403,"abstract":404},"cordis-european-research-council-award-682421","Targeting replication stress recovery pathways in oncology","ACADEMISCH ZIEKENHUIS GRONINGEN","€1,972,500","Genomic instability characterizes tumors, which have no clear ‘oncogenic-driver’ mutation, including triple-negative breast cancers (TNBCs). These patients do not benefit from molecularly targeted treatment and urgently need better treatment options. Increasing evidence points to replication stress as the driver of genomic instability. Since replication stress compromises cell viability, cells have evolved mechanisms to mitigate this threat. Recently, I discovered a novel cellular mechanism—mito",{"id":406,"funder":7,"programme":8,"title":407,"piName":10,"institution":408,"country":94,"year":13,"amount":409,"abstract":410},"cordis-european-research-council-award-682935","Pleiotropic treatment of cancer: RANK inhibitors targeting cancer stem cells and immunity","FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III","€1,999,960","Thousands of cancer patients worldwide are taking RANKL inhibitors for the management of bone metastasis, based on the key role of RANKL and its receptor, RANK, in osteoclasts. RANK signaling has multiple divergent effects in immunity and inflammation, both in the generation of active immune responses, as well as in the induction of tolerance. We showed that RANK overexpression induces stemness and interferes with differentiation in non transformed mammary epithelial cells and promotes mammary t",{"id":412,"funder":7,"programme":8,"title":413,"piName":10,"institution":414,"country":396,"year":13,"amount":68,"abstract":415},"cordis-european-research-council-award-682118","Role of Tumour Suppressor Gene Products of Common Fragile Sites in Human Diseases","THE HEBREW UNIVERSITY OF JERUSALEM","Common fragile sites (CFSs) are large chromosomal regions identified by conventional cytogenetics as sequences prone to breakage in cells subjected to replication stress. The interest in CFSs stems from their key role in DNA damage, resulting in chromosomal rearrangements. The instability of CFSs was correlated with genome instability in precancerous lesions and during tumour progression. Two opposing views dominate the discussion regarding the role of CFSs. One school of thought suggested that ",{"id":417,"funder":7,"programme":8,"title":418,"piName":10,"institution":419,"country":143,"year":13,"amount":10,"abstract":420},"cordis-european-research-council-award-681572","Synthetic viability of homologous recombination-deficient cancers","UNIVERSITAET BERN","Although various effective anti-cancer drug treatments have become available over the last decades, drug resistance remains the major cause of death of cancer patients. Striking examples are patients with tumors that are defective in DNA repair by homologous recombination (HR). Despite initial responses to cancer therapy, resistance of primary or disseminated tumors eventually emerges, which minimizes therapeutic options and greatly reduces survival. The molecular mechanisms underlying this ther",{"id":422,"funder":7,"programme":8,"title":423,"piName":10,"institution":424,"country":425,"year":13,"amount":426,"abstract":427},"cordis-european-research-council-award-681219","Personalized oncolytic vaccines for cancer immunotherapy","HELSINGIN YLIOPISTO","FI","€1,975,705","This grant application proposes to develop a novel, customizable and personalized anti-cancer vaccine: peptide-coated conditionally replicating adenovirus (PeptiCrad).Anti-cancer vaccines represent a promising approach for cancer treatment because they elicit durable and specific immune response that destroys primary tumors and distant metastases. Oncolytic viruses (OVs) are of significant interest because in addition to cytolysis they stimulate anti-tumor immune responses, thereby functioning a",{"id":429,"funder":7,"programme":8,"title":430,"piName":10,"institution":431,"country":25,"year":13,"amount":432,"abstract":433},"cordis-european-research-council-award-682881","Matrix during cancer progression","KOBENHAVNS UNIVERSITET","€1,997,500","The extracellular matrix (ECM) is known to play a critical role in driving cancer progression, and yet we lack knowledge of its composition and structure. The goal of my ERC project is to investigate how alterations in biochemical composition and structural properties of the ECM during cancer progression impact on cell behaviour to drive metastasis, which is responsible for over 90% of cancer patient deaths. In order to do this, my lab has developed a method to in situ decellularise organs leavi",{"id":435,"funder":7,"programme":8,"title":436,"piName":10,"institution":437,"country":12,"year":13,"amount":438,"abstract":439},"cordis-european-research-council-award-682903","Unraveling the origin of the Initial Mass Function","UNIVERSITE DE BORDEAUX","€1,859,413","Despite the tremendous progress achieved over the past decade, the study of stellar formation is far from complete. We have not yet measured the minimum mass for star formation, nor the shape of the IMF down to the least massive free-floating planets, or know how universal this shape is. Although clusters are the building blocks of galaxies, little is known about their early dynamical evolution and dispersal into the field. The main culprit for this state of affairs is the high level of contamin",{"id":441,"funder":7,"programme":8,"title":442,"piName":10,"institution":443,"country":32,"year":13,"amount":444,"abstract":445},"cordis-european-research-council-award-681988","Homogeneous Structures, Constraint Satisfaction Problems, and Topological Clones","TECHNISCHE UNIVERSITAET DRESDEN","€1,416,250","The complexity of constraint satisfaction problems (CSPs) is a field in rapid development, and involves central questions in graph homomorphisms, finite model theory, reasoning in artificial intelligence, and, last but not least, universal algebra. In previous work, it was shown that a substantial part of the results and tools for the study of the computational complexity of CSPs can be generalised to infinite domains when the constraints are definable over a homogeneous structure. There are man",{"id":447,"funder":7,"programme":8,"title":448,"piName":10,"institution":449,"country":62,"year":13,"amount":450,"abstract":451},"cordis-european-research-council-award-681296","Cross-Linguistic Acquisition of Sentence Structure: Integrating Experimental and Computational Approaches","THE UNIVERSITY OF LIVERPOOL","€1,600,000","How children acquire their native language remains one of the key unsolved problems in Cognitive Science. This project will answer a question that lies at the heart of this problem: How do children acquire the abstract generalizations that allow them to produce novel sentences, while avoiding the ungrammatical utterances that result from across-the-board application of these generalizations (e.g., *The clown laughed the man)? Previous single-process theories (the entrenchment, preemption and ver",{"id":453,"funder":7,"programme":8,"title":454,"piName":10,"institution":455,"country":383,"year":13,"amount":456,"abstract":457},"cordis-european-research-council-award-682540","Translational and Transdisciplinary research in Modeling Infectious Diseases","UNIVERSITEIT HASSELT","€1,639,168","TransMID focuses on the development of novel methods to estimate key epidemiological parameters from both serological and social contact data, with the aim to significantly expand the range of public health questions that can be adequately addressed using such data. Using new statistical and mathematical theory and newly collected as well as readily available serological and social contact data (mainly from Europe), fundamental mathematical and epidemiological challenges as outlined in the follo",{"id":459,"funder":7,"programme":8,"title":460,"piName":10,"institution":461,"country":62,"year":13,"amount":462,"abstract":463},"cordis-european-research-council-award-683033","Situating Free Speech: European parrhesias in comparative perspective","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€1,954,606","Recent tragic events in France and Denmark, and the debates and reactions which have followed them, have once again brought centre stage enduring questions surrounding ‘free speech’ in contemporary Europe: when and how can speech be ‘free’? With what consequences? Why and how does this come to matter differently to people in particular social and historical contexts? And what, if anything, is distinctive about Europe in this regard? Free speech has long been a topic that has attracted extensive ",{"id":465,"funder":7,"programme":8,"title":466,"piName":10,"institution":467,"country":126,"year":13,"amount":468,"abstract":469},"cordis-european-research-council-award-682275","Mass Spectrometry of Isomeric Ions","STICHTING RADBOUD UNIVERSITEIT","€1,612,500","Mass spectrometry (MS) in combination with electrospray ionization (ESI) is one of the principal tools currently used to gain insight into newly developed catalytic reactions. It is used to identify key reaction intermediates and to study their structure and reactivity. This proposal is based on the combination of modern MS approaches with novel experiments in a unique cryo-trapping instrument. This combination allows the study of short-lived ionic species that cannot be studied by other known m",{"id":471,"funder":7,"programme":8,"title":472,"piName":10,"institution":473,"country":12,"year":13,"amount":68,"abstract":474},"cordis-european-research-council-award-681679","Towards Novel Inert (Photo-)toxic Ru(II) Polypyridyl Complexes","ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS","In this grant application, I propose to investigate in-depth the potential of novel inert Ru(II) polypyridyl complexes as novel anticancer drug candidates. Such compounds were investigated by Dwyer and Shulman in 1950s and 1960s both in vitro and in vivo with relatively promising results. This impressive seminal work was unfortunately not followed-up. This lack of additional studies was recently attributed, at least in part, to the observed neurotoxicity of the complexes. Nonetheless, over the l",{"id":476,"funder":7,"programme":8,"title":477,"piName":10,"institution":478,"country":143,"year":13,"amount":68,"abstract":479},"cordis-european-research-council-award-682144","Atomic Force Microscopy for Molecular Structure Elucidation","IBM RESEARCH GMBH","Molecular structure elucidation is of great importance in synthetic chemistry, pharmacy, life sciences, energy and environmental sciences, and technology applications. To date structure elucidation by atomic force microscopy (AFM) has been demonstrated for a few, small and mainly planar molecules. In this project high-risk, high-impact scientific questions will be solved using structure elucidation with the AFM employing a novel tool and novel methodologies. A combined low-temperature scanning t",{"id":481,"funder":7,"programme":8,"title":482,"piName":10,"institution":83,"country":12,"year":13,"amount":10,"abstract":483},"cordis-european-research-council-award-647133","Intermediate Chaos","The transition from order to chaos has been a central theme of investigation in dynamical systems in the last two decades. Structures that exhibit a mix of deterministic and chaotic properties, for example, quasi-crystals, naturally arise in problems of geometry and mathematical physics. Despite intense study, key questions about these structures remain wide open.The proposed research is an investigation of intermediate chaos in ergodic theory of dynamical systems. Specific examples include syst",{"id":485,"funder":7,"programme":8,"title":486,"piName":10,"institution":487,"country":488,"year":13,"amount":489,"abstract":490},"cordis-european-research-council-award-681231","Non-invasive decoding of cortical patterns induced by goal directed movement intentions and artificial sensory feedback in humans","TECHNISCHE UNIVERSITAET GRAZ","AT","€1,994,161","In Europe estimated 300.000 people are suffering from a spinal cord injury (SCI) with 11.000 new injuries per year. The consequences of spinal cord injury are tremendous for these individuals. The loss of motor functions especially of the arm and grasping function – 40% are tetraplegics – leads to a life-long dependency on care givers and therefore to a dramatic decrease in quality of life in these often young individuals. With the help of neuroprostheses, grasp and elbow function can be substan",{"id":492,"funder":7,"programme":8,"title":493,"piName":10,"institution":494,"country":12,"year":13,"amount":495,"abstract":496},"cordis-european-research-council-award-681393","Modular Open Platform for Static Analysis","SORBONNE UNIVERSITE","€1,773,750","The Mopsa project aims at creating methods and tools to make computer software more reliable.Programming errors are pervasive with results ranging from user frustration to huge economical or human losses. Traditional test-based methods are insufficient to eliminate all errors. The project will develop static analyses able to detect at compile-time whole classes of program defects, leveraging the theory of abstract interpretation to design analyses that are approximate (to scale up to large progr",{"id":498,"funder":7,"programme":8,"title":499,"piName":10,"institution":93,"country":94,"year":13,"amount":10,"abstract":500},"cordis-european-research-council-award-681257","Lightning propagation and high-energy emissions within coupled multi-model simulations","More than 250 years after establishing the electrical nature of the lightning flash, we still do not understand how a lightning channel advances. Most of these channels progress not continuously but in a series of sudden jumps and, as they jump, they emit bursts of energetic radiation.  Despite increasingly accurate observations, there is no accepted explanation for this stepped progression.This proposal addresses this open question.  First, we propose a methodological breakthrough that will all",{"id":502,"funder":7,"programme":8,"title":503,"piName":10,"institution":93,"country":94,"year":13,"amount":504,"abstract":505},"cordis-european-research-council-award-681275","High throughput mass spectrometry of single proteins in liquid environment","€2,470,283","Although mass spectrometry has brought about major advancements in proteomics in the last decade, protein mass spectrometers still have important limitations. One fundamental limitation is that they require sample ionization, desorption into the gas phase and fragmentation, clearly leading to protein denaturation. Since relevant protein complexes are unstable or transient, their characterization in its native state and physiological environment remains an unexplored route towards the full unders",{"id":507,"funder":7,"programme":8,"title":508,"piName":10,"institution":61,"country":62,"year":13,"amount":509,"abstract":510},"cordis-european-research-council-award-681546","Family size matters: How low fertility affects the (re)production of social inequalities","€1,902,598","This is the first comprehensive study on the consequences of low fertility for the (re)production of social inequalities. Inequalities in socio-economic well-being, including gender inequalities and regional inequalities, are reproduced from generation to generation. The family plays a central role in the reproduction of social inequalities. Over the last 5 decades, most societies in Europe and East-Asia moved or started moving towards low fertility regimes where the majority of women bear 0, 1 ",{"id":512,"funder":7,"programme":8,"title":513,"piName":10,"institution":142,"country":143,"year":13,"amount":514,"abstract":515},"cordis-european-research-council-award-682588","Foundations of Factorized Data Management Systems","€1,980,966","The objective of this project is to investigate scalability questions arising with a new wave of smart relational data management systems that integrate analytics and query processing. These questions will be addressed by a fundamental shift from centralized processing on tabular data representation, as supported by traditional systems and analytics software packages, to distributed and approximate processing on factorized data representation.Factorized representations exploit algebraic properti",{"id":517,"funder":7,"programme":8,"title":518,"piName":10,"institution":61,"country":62,"year":13,"amount":519,"abstract":520},"cordis-european-research-council-award-648311","Computational Propaganda: Investigating the Impact of Algorithms and Bots on Political Discourse in Europe","€1,980,112","Social media can have an impressive impact on civic engagement and political discourse. Yet increasingly we find political actors using digital media and automated scripts for social control. Computational propaganda—through bots, botnets, and algorithms—has become one of the most concerning impacts of technology innovation. Unfortunately, bot identification and impact analysis are among the most difficult research challenges facing the social and computer sciences.COMPROP objectives are to adva",{"id":522,"funder":7,"programme":8,"title":523,"piName":10,"institution":61,"country":62,"year":13,"amount":524,"abstract":525},"cordis-european-research-council-award-681491","Autocatalysis: A bottom-up approach to understanding the origins of life","€2,278,073","The origin of life is not well understood, and is one of the great remaining questions in science. Autocatalytic chemical reactions have been extensively studied with the aim of providing insight into the principles underlying living systems. In biology, organisms can be thought of as imperfect self-replicators, which produce closely related species, allowing for selection and evolution. Autocatalysis is also an important part of many other biological processes. This project aims to develop new ",{"id":527,"funder":7,"programme":8,"title":528,"piName":10,"institution":529,"country":143,"year":13,"amount":10,"abstract":530},"cordis-european-research-council-award-681505","Molecular dissection of the mechanisms of cell-cell fusion in the fission yeast","UNIVERSITE DE LAUSANNE","Cell fusion is critical for fertilization and development, for instance underlying muscle or bone formation. Cell fusion may also play important roles in regeneration and cancer. A conceptual understanding is emerging that cell fusion requires cell-cell communication, polarization of the cells towards each other, and assembly of a fusion machinery, in which an actin-based structure promotes membrane juxtaposition and fusogenic factors drive membrane fusion. However, in no single system have the ",{"id":532,"funder":7,"programme":8,"title":533,"piName":10,"institution":461,"country":62,"year":13,"amount":534,"abstract":535},"cordis-european-research-council-award-681565","Empirical Demand and Welfare Analysis","€1,426,418","Measurement of consumer welfare is central to economic evaluations. It underlies calculation of price-indices, formulation of tax policies, and environmental and industrial regulation. But existing measurement methods rely on restrictive assumptions about consumer preferences, leading to potentially incorrect conclusions regarding policy-impacts. The proposed project aims to make fundamental contributions to empirical welfare analysis by developing nonparametric approaches, which would avoid suc",{"id":537,"funder":7,"programme":8,"title":538,"piName":10,"institution":382,"country":383,"year":13,"amount":539,"abstract":540},"cordis-european-research-council-award-646671","Maintaining synaptic function for a healthy brain: Membrane trafficking and autophagy in neurodegeneration","€1,999,025","Neurodegeneration is characterized by misfolded proteins and dysfunctional synapses. Synapses are often located very far away from their cell bodies and they must therefore largely independently cope with the unfolded, dysfunctional proteins that form as a result of synaptic activity and  stress. My hypothesis is that synaptic terminals have adopted specific mechanisms to maintain robustness over their long lives and that these may become disrupted in neurodegenerative diseases. Recent evidence ",{"id":542,"funder":7,"programme":8,"title":543,"piName":10,"institution":544,"country":32,"year":13,"amount":545,"abstract":546},"cordis-european-research-council-award-681269","Decorative Principles in late Republican and early Imperial Italy","CHRISTIAN-ALBRECHTS-UNIVERSITAET  ZU KIEL","€1,996,971","This project will provide a comprehensive analysis of the decorative principles employed between the late Republic and the end of the early Imperial period, i.e. the 2nd century BC and the end of the 1st century AD. It will be the first research programme to move away from analyses of single decorative elements in isolation and to focus on their correlation and interaction. This comprehensive approach will be adopted for varying spatial contexts such as houses, sanctuaries and main streets, enab",{"id":548,"funder":7,"programme":8,"title":549,"piName":10,"institution":550,"country":62,"year":13,"amount":551,"abstract":552},"cordis-european-research-council-award-682723","Graphene based smart surfaces: from visible to microwave","THE UNIVERSITY OF MANCHESTER","€1,995,625","The aim of this proposal is to develop adaptive camouflage systems using graphene-enabled smart surfaces. We propose a new class of active surfaces capable of real-time electrical-control of its appearance in a very broad spectrum ranging from visible to microwave covering 6 orders of magnitude in wavelength. The proposed method relies on controlling electromagnetic waves by tuning density of high-mobility charges on single or multilayers of atomically thin graphene electrodes. We will realize t",{"id":554,"funder":7,"programme":8,"title":555,"piName":10,"institution":556,"country":32,"year":13,"amount":557,"abstract":558},"cordis-european-research-council-award-682512","Oxygen flux measurements as a new tracer for the carbon and nitrogen cycles in terrestrial ecosystems","GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS","€1,999,502","Atmospheric oxygen (O2) measurements have proven to be one of the most powerful tools to study the carbon cycle at global scale, quantifying the carbon dioxide (CO2) sink of terrestrial ecosystems and oceans. At ecosystem level, O2 is closely related to CO2 through photosynthesis and respiration, and is influenced by sources of nitrogen during plant uptake. O2 thus carries valuable information about ecosystem processes that cannot be learned from CO2 alone. However, the potential of O2 measureme",{"id":560,"funder":7,"programme":8,"title":561,"piName":10,"institution":562,"country":12,"year":13,"amount":563,"abstract":564},"cordis-european-research-council-award-683029","Ultimate Angular Resolution Astrophysics with kernel-phase and full-aperture interferometry","OBSERVATOIRE DE LA COTE D'AZUR (OCA)","€1,717,811","Astronomy requires large telescopes to improve the sensitivity and the angular resolution of its observations. Of these qualities, angular resolution is the most difficult to maintain in the optical and near-infrared, since the atmosphere reduces it to that of a 10 cm aperture, regardless of the telescope size. On the one-hand, Adaptive Optics (AO) actively compensates for this effect but the improvement is often partial only. On the other hand, interferometric techniques (most notably sparse ap",{"id":566,"funder":7,"programme":8,"title":567,"piName":10,"institution":414,"country":396,"year":13,"amount":568,"abstract":569},"cordis-european-research-council-award-681819","Evolution of antibiotic tolerance in the 'wild': A quantitative approach","€1,978,750","Bacterial ability to evolve strategies for evading antibiotic treatment is a fascinating example of an evolutionary process, as well as a major health threat. Despite efforts to understand treatment failure, we lack the means to prevent evolution of resistance when a new drug is released to the market. Most efforts are directed towards understanding the mechanisms of antibiotic resistance. Whereas ‘resistance’ is due to mutations that enable microorganisms to grow even at high concentrations of ",{"id":571,"funder":7,"programme":8,"title":572,"piName":10,"institution":573,"country":62,"year":13,"amount":574,"abstract":575},"cordis-european-research-council-award-681559","Stereocontrolled Polymerisation: New Frontiers in Synthesis and Supramolecular Self Assembly","THE UNIVERSITY OF BIRMINGHAM","€2,074,731","Nature has evolved the ability to create large and complex molecules in which the 3-dimensional orientation of the atoms is critical to their performance. The essential nature of stereochemistry to the structure, and hence performance, of biopolymers makes it reasonable to expect such aspects of synthetic materials to be equally important. This area has however received little study, which is partially a consequence of the significant challenges of creating large macromolecules with well-defined",{"id":577,"funder":7,"programme":8,"title":578,"piName":10,"institution":579,"country":425,"year":13,"amount":580,"abstract":581},"cordis-european-research-council-award-648766","How elephants grow old","TURUN YLIOPISTO","€1,949,316","The ageing population structure of most European countries has major health, economic and social consequences that lead to a need to better understand both the evolutionary limitations of deferring ageing, as well as the mechanisms involved in growing old. Ageing involves reduced fertility, mobility and ability to combat disease, but some individuals cope with growing old better than others. Improving the quality of life at old age and predicting future changes in longevity patterns of societies",{"id":583,"funder":7,"programme":8,"title":584,"piName":10,"institution":585,"country":586,"year":13,"amount":587,"abstract":588},"cordis-european-research-council-award-647125","Liveable disabilities: Life courses and opportunity structures across time","UMEA UNIVERSITET","SE","€1,999,870","In Europe today disabled people comprise some 65 million (10%). Yet they are marginalized in society and research, and little is known on how disabilities become liveable. This project challenges this bias by proposing to investigate ‘liveable disabilities’ as a function of disability and opportunity structures across time. It analyses four life course dimensions: disabled people’s (1) health and well-being; (2) involvement in education and work; (3) in a partner relationship and family; and (4)",{"id":590,"funder":7,"programme":8,"title":591,"piName":10,"institution":592,"country":593,"year":13,"amount":594,"abstract":595},"cordis-european-research-council-award-681460","Market Selection, Frictions, and the Information Content of Prices","KOC UNIVERSITY","TR","€1,089,432","This project studies information aggregation in multiple-linked auction markets with large numbers of goods and bidders. Past work assumes bidders trade in a single, centralized, frictionless auction market. Instead, I study bidders with unit demand who decide to purchase one of many possible goods which are on auction in distinct markets. The goods traded in each market are identical, common-value objects and the price is determined by a uniform-price auction. Bidders receive imperfect signals ",{"id":597,"funder":7,"programme":8,"title":598,"piName":10,"institution":599,"country":94,"year":13,"amount":10,"abstract":600},"cordis-european-research-council-award-681575","Market Design: Theory and Applications in Development","UNIVERSIDAD CARLOS III DE MADRID","There are two components to my research plan.First is the study of dynamic markets for real and financial assets in which traders might have asymmetric information. In particular I aim to understand how different characteristics of the market such as frequency of trade and transparency affect the efficiency with which these markets operate. This is a stepping stone to then be able to understand how these markets can be designed or regulated to improve their efficiency. Allowing for competition a",{"id":602,"funder":7,"programme":8,"title":603,"piName":10,"institution":604,"country":126,"year":13,"amount":68,"abstract":605},"cordis-european-research-council-award-681632","The neural basis of prosocial development in adolescence","ERASMUS UNIVERSITEIT ROTTERDAM","Adolescence is an important transition period in life, where individuals gain independence from their caregivers and develop into adults who pursue their own goals. Our understanding of this transition period has benefited from two decades of research on brain development, in which it was discovered that adolescence represents a period of risk for heightened emotional reactivity, and that the developing brain in adolescence is much more plastic than previously thought. The existing models, howev",{"id":607,"funder":7,"programme":8,"title":608,"piName":10,"institution":609,"country":32,"year":13,"amount":610,"abstract":611},"cordis-european-research-council-award-681529","Simulation and Understanding of the Atmospheric Radical Budget for Regions with Large Emissions from Plants","FORSCHUNGSZENTRUM JULICH GMBH","€1,850,000","Atmospheric pollutants emitted by natural and anthropogenic sources influence significantly the quality of life on our planet. Their removal in the atmosphere is controlled by their reactions with photochemically produced hydroxyl radicals. Recent findings from experimental studies and quantum-chemical calculations suggest that an important part of atmospheric radical chemistry, which is directly linked to the self-cleansing ability of our atmosphere, has been overlooked. This causes considerabl",{"id":613,"funder":7,"programme":8,"title":614,"piName":10,"institution":615,"country":62,"year":13,"amount":616,"abstract":617},"cordis-european-research-council-award-646625","Understanding and exploiting the insect P450 resistome","THE UNIVERSITY OF EXETER","€1,975,512","Insect resistance to synthetic insecticides and the anti-herbivore defence chemicals produced by many plants is an ongoing challenge to sustainable pest management while also an exceptional model system to study adaptive evolution. The cytochrome P450s are a superfamily of enzymes that are ubiquitous in nature, and one of the most important enzyme families used by insects to defend themselves against natural and synthetic xenobiotics. Insects have been shown to evolve resistance through quantita",{"id":619,"funder":7,"programme":8,"title":620,"piName":10,"institution":621,"country":126,"year":13,"amount":622,"abstract":623},"cordis-european-research-council-award-682077","Political Apologies across Cultures","TILBURG UNIVERSITY- UNIVERSITEIT VAN TILBURG","€1,917,713","In the past decades, there has been a considerable rise in the number of apologies offered by states for injustices and human rights violations. Among transitional justice scholars, there is significant debate about how useful such apologies are. Whereas some have applauded these gestures as an important step in peacemaking processes, others have argued that they may not fit in all cultures and may even be a risky tool for peacemaking. Unfortunately, theorizing and research in the field of trans",{"id":625,"funder":7,"programme":8,"title":626,"piName":10,"institution":627,"country":383,"year":13,"amount":628,"abstract":629},"cordis-european-research-council-award-683184","The Physics of Galaxies 7 Gyr Ago","UNIVERSITEIT GENT","€1,884,875","Over the past decade, redshiftsurveys and multi-wavelength imaging campaigns have drawn up anempirical picture of how many stars had formed in which types ofgalaxies over the history of the universe.  However, we have yet tounravel the individual pathways along which galaxies evolve, and thephysical processes that drive them.  Continuing with the previousapproach -- larger and deeper photometric samples -- is not adequateto achieve this goal.  A change of focus is required.In this ERC project I ",{"id":631,"funder":7,"programme":8,"title":632,"piName":10,"institution":478,"country":143,"year":13,"amount":633,"abstract":634},"cordis-european-research-council-award-682675","PROJECTED MEMRISTOR: A nanoscale device for cognitive computing","€2,555,525","We are entering the third era of computing: cognitive computing, which holds great promise in terms of deriving intelligence\u002Fknowledge from huge volumes of data. Today’s cognitive computers are based on the von Neumann architecture, in which the computing and the memory units are separated. Cognitive computing, however, is inherently data-centric, meaning that huge amounts of data need to be shuttled back and forth at high speeds, a task at which that architecture is highly inefficient.It is bec",{"id":636,"funder":7,"programme":8,"title":637,"piName":10,"institution":638,"country":586,"year":13,"amount":639,"abstract":640},"cordis-european-research-council-award-681712","Pathways to Alzheimer's disease","GOETEBORGS UNIVERSITET","€1,985,093","Critical to our understanding of Alzheimer’s disease (AD) and also to finding therapies is determining how key pathological factors interact and relate to neuronal toxicity, symptoms and disease progression. My research has focussed on amyloid beta (Aβ) moities and demonstrated that cerebrospinal fluid (CSF) Aβ42 correlates with cerebral Aβ pathology; that Aβ accumulates in the brain 10-20 years prior to onset of symptoms; and that CSF Aβ abnormalities precede CSF tau changes. However, it is inc",{"id":642,"funder":7,"programme":8,"title":643,"piName":10,"institution":461,"country":62,"year":13,"amount":644,"abstract":645},"cordis-european-research-council-award-682754","The Physical  Mechanics of Swimming Bacteria","€1,999,229","Bacteria play a critical role in the life of higher organisms. Their behavior is constrained by the physical properties of their habitat: first and foremost, the presence of a surrounding fluid. Most bacteria are motile, and most motile bacteria swim in fluids using slender helical appendages called flagella rotated by specialized motors. While many bacteria have only one flagellum, most well-studied pathogenic bacteria possess multiple flagella. Why have some bacteria evolved to use many flagel",{"id":647,"funder":7,"programme":8,"title":648,"piName":10,"institution":649,"country":32,"year":13,"amount":10,"abstract":650},"cordis-european-research-council-award-647434","Many-Body Physics with Driven Open Quantum Systems of Atoms, Light and Solids","UNIVERSITAT ZU KOLN","Understanding the quantum many-particle problem is one of the grand challenges of modern physics. Whiletremendous progresses have been made over the past decades in thermodynamic equilibrium, nonequilibriummany-body quantum physics is still in its infancy. Strong motivation for addressing thischallenge comes from recent experimental developments in diverse areas, ranging from cold atomic gasesover light-driven semiconductors to microcavity arrays. This moves systems into the focus, which areloca",{"id":652,"funder":7,"programme":8,"title":653,"piName":10,"institution":654,"country":32,"year":13,"amount":655,"abstract":656},"cordis-european-research-council-award-681365","Structural basis for the coordination of chromosome architecture by condensin complexes","JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG","€1,982,479","Chromosomes undergo dramatic changes in their three-dimensional organisation during all aspects of genome function, ranging from the regulation of gene expression during cellular differentiation to chromosome duplication and partitioning over the course of a cell division cycle. The multi-subunit condensin protein complex plays major roles for these changes in DNA topology. Despite its fundamental importance, the mechanisms of condensin’s action are not understood.Here, I propose a comprehensive",{"id":658,"funder":7,"programme":8,"title":659,"piName":10,"institution":487,"country":488,"year":13,"amount":660,"abstract":661},"cordis-european-research-council-award-681402","Securing Software against Physical Attacks","€1,964,750","More than 15 years ago, several seminal publications showed that cryptographic keys can be revealed by analysing the power consumption or by inducing faults to devices like smart cards. The publication of these so-called physical attacks sparked off research on all kinds of attack techniques and countermeasures to secure implementations of cryptographic schemes. However, a system can still be attacked easily if only the execution of cryptographic schemes is secured. An attacker can for example i",{"id":663,"funder":7,"programme":8,"title":664,"piName":10,"institution":665,"country":39,"year":13,"amount":666,"abstract":667},"cordis-european-research-council-award-681447","Advanced Reduced Order Methods with Applications in Computational Fluid Dynamics","SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE","€1,656,579","The aim of AROMA-CFD is to create a team of scientists at SISSA for the development of Advanced Reduced Order Modelling techniques with a focus in Computational Fluid Dynamics (CFD), in order to face and overcome many current limitations of the state of the art and improve the capabilities of reduced order methodologies for more demanding applications in industrial, medical and applied sciences contexts. AROMA-CFD deals with strong methodological developments in numerical analysis, with a specia",{"id":669,"funder":7,"programme":8,"title":670,"piName":10,"institution":419,"country":143,"year":13,"amount":671,"abstract":672},"cordis-european-research-council-award-681518","Indigenous Communities, Land Use and Tropical Deforestation","€1,952,183","Tropical deforestation is an important contributor to climate change, through the release of significant amounts of carbon in the atmosphere. The main proximate cause of deforestation in tropical regions is agricultural expansion, followed by timber extraction. The general objective of this research is to understand how the interaction of technological, environmental, economic and social factors influence land use dynamics, including household decisions, about agricultural expansion and resource",{"id":674,"funder":7,"programme":8,"title":675,"piName":10,"institution":676,"country":62,"year":13,"amount":677,"abstract":678},"cordis-european-research-council-award-682313","Forensic Architecture: The Media Environments of Conflict","GOLDSMITHS' COLLEGE","€1,996,830","Forensic Architecture is an emergent field that refers to the presentation of architectural evidence in legal contexts. As contemporary conflicts increasingly take place within urban areas, homes and neighbourhoods become targets and a growing number of civilian casualties occur within cities and buildings. Architectural investigation thus becomes an essential tool of conflict analysis, not only for its crucial role in the pursuit of accountability, but also because it enables ground breaking me",{"id":680,"funder":7,"programme":8,"title":681,"piName":10,"institution":461,"country":62,"year":13,"amount":682,"abstract":683},"cordis-european-research-council-award-681987","Synthesizing Meiotic Crossover Hotspots in Arabidopsis","€1,999,953","The majority of eukaryotes reproduce sexually via meiosis. During meiosis homologous chromosomes pair and undergo reciprocal genetic exchange termed crossover. Meiotic recombination is a major evolutionary force and has a profound effect on patterns of genetic diversity in sexual species. Crossovers distributions are highly non-random and are typically focused in narrow hotspots. Study of hotspots throughout eukaryotes has revealed combinations of genetic and epigenetic factors that contribute t",{"id":685,"funder":7,"programme":8,"title":686,"piName":10,"institution":431,"country":25,"year":13,"amount":687,"abstract":688},"cordis-european-research-council-award-682549","Mumps VIRus EXploitation of the human adhesion receptor GPR125","€1,813,367","Mumps virus is a re-emerging pathogen that causes painful inflammatory symptoms, such as parotitis (salivary gland infection) and orchitis (testis infection). It is highly neurotropic with evidence of brain infection in half of cases and clinical evidence in up to 10%. It is a small RNA virus belonging to the family of paramyxoviridae that includes e.g. viruses for measles and pneumonia, all having a huge impact on global economics and human health. Current vaccine programs have not managed to e",{"id":690,"funder":7,"programme":8,"title":691,"piName":10,"institution":692,"country":396,"year":13,"amount":693,"abstract":694},"cordis-european-research-council-award-647943","Judicial Conflict Resolution: Examining Hybrids of Non-adversarial Justice","BAR ILAN UNIVERSITY","€1,272,534","In the past few decades, the role of judges has changed dramatically and its nature has remained largely unexplored. To date, most cases settle or reach plea-bargaining, and the greater part of judges’ time is spent on managing cases and encouraging parties to reach consensual solutions. Adjudication based on formal rules is a rare phenomenon which judges mostly avoid. The hypothesis underlying JCR is that the various Conflict Resolution methods which are used outside the courtroom, as alternati",{"id":696,"funder":7,"programme":8,"title":697,"piName":10,"institution":698,"country":62,"year":13,"amount":699,"abstract":700},"cordis-european-research-council-award-682734","Identifying Predictors of Risk and Resilience for poor neuropsychological Outcome following childhood Brain InsulTs (PROBIt)","ASTON UNIVERSITY","€2,226,923","The impact of insults to the developing brain upon cognition and behaviour has far-reaching consequences for the child, their family, education and health care systems, and government expenditure. Many variables (illness, environmental) contribute to different outcomes following similar insults, and they exert their influence via the child’s developing brain. Predicting which child will recover from early brain insult and identifying those at risk of poor outcome represents a major challenge, wi",{"id":702,"funder":7,"programme":8,"title":703,"piName":10,"institution":704,"country":39,"year":13,"amount":705,"abstract":706},"cordis-european-research-council-award-648734","What is everybody doing? Social prediction, categorization, and monitoring in the Prefrontal Cortex of the Macaque  adopting a new human-monkey (H-M) interactive paradigm.","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","€1,028,750","Primates live in a complex social environment, in which they need to maintain track of their past social interactions and learn to formulate prediction on what specific groupmates are likely to do based on their past experiences. I have previously contributed to show that the PF (prefrontal cortex) has a main function in the generation of goals based on the current contexts and events, but its role in social cognition is still little explored. In this context, the frontal Pole cortex (FPC) has b",{"id":708,"funder":7,"programme":8,"title":709,"piName":10,"institution":710,"country":32,"year":13,"amount":711,"abstract":712},"cordis-european-research-council-award-646696","The listening challenge: How ageing brains adapt","UNIVERSITAET zu LUEBECK","€1,967,000","Humans in principle adapt well to sensory degradations. In order to do so, our cognitive strategies need to adjust accordingly (a process we term “adaptive control”).The auditory sensory modality poses an excellent, although under-utilised, research model to understand these adjustments, their neural basis, and their large variation amongst individuals. Hearing abilities begin to decline already in the fourth life decade, and our guiding hypothesis is that individuals differ in the extent to whi",{"id":714,"funder":7,"programme":8,"title":715,"piName":10,"institution":716,"country":32,"year":13,"amount":717,"abstract":718},"cordis-european-research-council-award-683083","Reactivity and Assembly of Multifunctional, Stimuli-responsive Encapsulation Structures","TECHNISCHE UNIVERSITAT DORTMUND","€1,982,500","In biochemical systems, combinations of specialized molecular entities are precisely arranged to give highly complex architectures. Sophisticated functionality, such as the selective chemical transformation of substrates in enzymes, emerges from the interplay of the individual components that are often grouped around a nanoscopic cavity. Control mechanisms based on the cooperative binding of signal substances regulate the enzyme’s action, and complicated feedback loops may apply.Since the advent",{"id":720,"funder":7,"programme":8,"title":721,"piName":10,"institution":722,"country":383,"year":13,"amount":723,"abstract":724},"cordis-european-research-council-award-646758","Astrochemistry of old stars: direct probing of unique chemical laboratories","KATHOLIEKE UNIVERSITEIT LEUVEN","€2,605,897","The gas and dust in the interstellar medium (ISM) drive the chemical evolution of galaxies, the formation of stars and planets, and the synthesis of complex prebiotic molecules. The prime birth places for this interstellar material are the winds of evolved (super)giant stars. These winds are unique chemical laboratories, in which a large variety of gas and dust species radially expand away from the star.Recent progress on the observations of these winds has been impressive thanks to Herschel and",{"id":726,"funder":7,"programme":8,"title":727,"piName":10,"institution":728,"country":62,"year":13,"amount":729,"abstract":730},"cordis-european-research-council-award-682315","A programming language bridging theory and practice for scientific data curation","THE UNIVERSITY OF EDINBURGH","€1,995,181","Science is increasingly data-driven. Scientific research funders now routinely mandate open publication of publicly-funded research data. Safely reusing such data currently requires labour-intensive curation. Provenance recording the history and derivation of the data is critical to reaping the benefits and avoiding the pitfalls of data sharing. There are hundreds of curated scientific databases in biomedicine that need fine-grained provenance; one important example is GtoPdb, a pharmacological ",{"id":732,"funder":7,"programme":8,"title":733,"piName":10,"institution":734,"country":62,"year":13,"amount":735,"abstract":736},"cordis-european-research-council-award-681489","IN-TOUCH:  Digital Touch and Communication","UNIVERSITY COLLEGE LONDON","€1,947,346","The rapid expansion of digital touch technologies is set to reconfigure touch and the tactile in significant ways, much as optical technologies transformed sight and the visual. This has immense social significance for communication. There are, however, major gaps in our understanding of touch as it is digitally mediated, and methods are under-developed for a social account of digital touch communication. This project will break new ground as the first comprehensive study of digital touch commun",{"id":738,"funder":7,"programme":8,"title":739,"piName":10,"institution":414,"country":396,"year":13,"amount":740,"abstract":741},"cordis-european-research-council-award-682150","Ergodic theory and additive combinatorics","€1,342,500","The last decade has witnessed a new spring for dynamical systems. The field - initiated by Poincare in the study of the N-body problem - has become essential in the understanding of seemingly far off fields such as combinatorics, number theory and theoretical computer science. In particular, ideas from ergodic theory played an important role in the resolution of long standing open problems in combinatorics and number theory. A striking example is the role of dynamics on nilmanifolds in the recen",{"id":743,"funder":7,"programme":8,"title":744,"piName":10,"institution":745,"country":586,"year":13,"amount":746,"abstract":747},"cordis-european-research-council-award-682663","Understanding microbe-induced stomach cancer – the key to a workable strategy for worldwide prevention","KAROLINSKA INSTITUTET","€1,941,531","Stomach cancer is the 4th most common cancer and 2nd leading cause of cancer-related death worldwide. The aim of this proposal is to deepen the understanding of mechanisms involved in microbe-induced gastric carcinogenesis, which will facilitate risk stratification for identification of high-risk groups and may offer new opportunities for pharmacological and probiotic prevention. We hypothesize that novel H. pylori genotypic variation can predict carcinogenicity. The cancer-causing H. pylori str",{"id":749,"funder":7,"programme":8,"title":750,"piName":10,"institution":751,"country":752,"year":13,"amount":753,"abstract":754},"cordis-european-research-council-award-683080","A unified theory of finite-state recognisability","UNIWERSYTET WARSZAWSKI","PL","€1,768,125","Finite-state devices like finite automata and monoids on finite words, or extensions to trees and infinite objects, are fundamental tools of logic in computer science. There are tens of models in the literature, ranging from finite automata on finite words to weighted automata on infinite trees. Many existing finite-state models share important similarities, like existence of canonical (minimal) devices, or decidability of emptiness, or a logic-automata connection. The first and primary goal of ",{"id":756,"funder":7,"programme":8,"title":757,"piName":10,"institution":550,"country":62,"year":13,"amount":758,"abstract":759},"cordis-european-research-council-award-681431","Delivering on the Promise of Measuring Dark Energy from Cosmic Lensing","€1,997,219","The apparent gravitational distortion of distant galaxies, ‘cosmic lensing’, allows us to map dark matter and hence unveil the nature of the mysterious dark energy. I will develop novel approaches to cosmic lensing and use these to place constraints on dark energy using the Dark Energy Survey (DES). Themes 1 and 2 address key systematic effects crucial for the extraction of cosmology in theme 3. Theme 1: The lensing community has spent two decades trying to find the perfect galaxy shape measurem",{"id":761,"funder":7,"programme":8,"title":762,"piName":10,"institution":763,"country":12,"year":13,"amount":764,"abstract":765},"cordis-european-research-council-award-682387","Revolutionizing Insect Control","CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LEDEVELOPPEMENT - C.I.R.A.D. EPIC","€1,993,281","EFSA recently prohibited 75% of insecticides to account for their toxicity and ecotoxicity. Moreover, the spread of insecticide resistance and invasion of Europe by new tropical vectors and pests require the development of alternative biological techniques.Recently, we hypothesized that shifting the vision of the sterile male from a sexual competitor only to a specific transporter of active biocides to the targeted female might boost the impact of the sterile insect technique (SIT). Here we want",{"id":767,"funder":7,"programme":8,"title":768,"piName":10,"institution":461,"country":62,"year":13,"amount":769,"abstract":770},"cordis-european-research-council-award-683043","Resolving subglacial properties, hydrological networks and dynamic evolution of ice flow on the Greenland Ice Sheet","€2,443,800","The Greenland Ice Sheet is losing mass at a growing rate and has since 2010 caused sea level rise of 1 mm\u002Fyear. The most severe changes occur in the drainage basins of marine-terminating glaciers, which flow rapidly and drain 88% of the ice sheet. The latest report by the Intergovernmental Panel on Climate Change concluded that the widespread acceleration of these glaciers in recent years was a response to interaction with the ocean and unrelated to basal lubrication of ice flow; yet, observatio",{"id":772,"funder":7,"programme":8,"title":773,"piName":10,"institution":774,"country":94,"year":13,"amount":450,"abstract":775},"cordis-european-research-council-award-682602","Biogeochemical and ecosystem interactions with socio-economic activity in the global ocean","UNIVERSITAT AUTONOMA DE BARCELONA","The global marine ecosystem is being deeply altered by human activity. On the one hand, rising concentrations of atmospheric greenhouse gases are changing the physical and chemical state of the ocean, exerting pressure from the bottom up. Meanwhile, the global fishery has provided large economic benefits, but in so doing has restructured ecosystems by removing most of the large animal biomass, a major top-down change. Although there has been a tremendous amount of research into isolated aspects ",{"id":777,"funder":7,"programme":8,"title":778,"piName":10,"institution":728,"country":62,"year":13,"amount":10,"abstract":779},"cordis-european-research-council-award-681760","Translating from Multiple Modalities into Text","Recent years have witnessed the development of a wide range of computational methods that process and generate natural language text.  Many of these have become familiar to mainstream computer users such as tools that retrieve documents matching a query, perform sentiment analysis, and translate between languages. Systems like Google Translate can instantly translate between any pair of over fifty human languages allowing users to read web content that wouldn't have otherwise been available. The",{"id":781,"funder":7,"programme":8,"title":782,"piName":10,"institution":728,"country":62,"year":13,"amount":68,"abstract":783},"cordis-european-research-council-award-681181","Imaging synaptic contributors to dementia","Alzheimer's disease, the most common cause of dementia in older people, is a devastating condition that is becoming a public health crisis as our population ages. Despite great progress recently in Alzheimer’s disease research, we have no disease modifying drugs and a decade with a 99.6% failure rate of clinical trials attempting to treat the disease.   This project aims to develop relevant therapeutic targets to restore brain function in Alzheimer’s disease by integrating human and model studie",{"id":785,"funder":7,"programme":8,"title":786,"piName":10,"institution":787,"country":39,"year":13,"amount":788,"abstract":789},"cordis-european-research-council-award-681798","Biomimetic trick to re-balance Osteblast-Osteoclast loop in osteoporoSis treatment: a Topological and materials driven approach","POLITECNICO DI TORINO","€1,977,500","One out of 5 people in their fifties will experience a bone fracture due to osteoporosis (OP)-induced fragility in their lifetime. The OP socio-economic burden is dramatic and involves tens of millions of people in the EU, with a steadily increasing number due to population ageing. Current treatments entail drug-therapy coupled with a healthy lifestyle but OP fractures need mechanical fixation to rapidly achieve union: the contribution of biomaterial scientists in this field is still far from ta",{"id":791,"funder":7,"programme":8,"title":792,"piName":10,"institution":38,"country":39,"year":13,"amount":793,"abstract":794},"cordis-european-research-council-award-647057","REDOX SIGNALING AND METABOLIC STATES IN ANGIOGENESIS IN HEALTH AND DISEASE","€1,999,827","Endothelial cells (ECs) exhibit a remarkable and unique plasticity in terms of redox biology and metabolism. They can quickly adapt to oxygen, nitric oxide and metabolic variations. Therefore, EC must be equipped with a selective and unique repertoire of redox and metabolic mechanisms, that play a crucial role to preserve redox balance, and adjust metabolic conditions in both normal and pathological angiogenesis. The identification of such redox signaling and metabolic pathways is crucial to the",{"id":796,"funder":7,"programme":8,"title":797,"piName":10,"institution":798,"country":799,"year":13,"amount":10,"abstract":800},"cordis-european-research-council-award-683024","Two-Dimensional Chemistry towards New Graphene Derivatives","UNIVERZITA PALACKEHO V OLOMOUCI","CZ","The suite of graphene’s unique properties and applications can be enormously enhanced by its functionalization. As non-covalently functionalized graphenes do not target all graphene’s properties and may suffer from limited stability, covalent functionalization represents a promising way for controlling graphene’s properties. To date, only a few well-defined graphene derivatives have been introduced. Among them, fluorographene (FG) stands out as a prominent member because of its easy synthesis an",{"id":802,"funder":7,"programme":8,"title":803,"piName":10,"institution":804,"country":488,"year":13,"amount":805,"abstract":806},"cordis-european-research-council-award-681432","Dipolar Physics and Rydberg Atoms with Rare-Earth Elements","UNIVERSITAET INNSBRUCK","€1,992,368","Strongly magnetic rare-earth atoms are fantastic species to study few- and many-body dipolar quantum physics with ultracold gases. Their appeal leans on their spectacular properties (many stable isotopes, large dipole moment, unconventional interactions, and a rich atomic spectrum). In 2012 my group created the first Bose-Einstein condensate of erbium and shortly thereafter the first degenerate Fermi gas. My pioneering studies, together with the result on dysprosium by the Lev´s group, have trig",{"id":808,"funder":7,"programme":8,"title":809,"piName":10,"institution":734,"country":62,"year":13,"amount":810,"abstract":811},"cordis-european-research-council-award-682539","Charge Carrier Transport in Soft Matter: From Fundamentals to High-Performance Materials","€1,989,988","Charge transport (CT) in soft condensed matter is at the heart of many exciting and potentially revolutionising technologies ranging from organic photovoltaic cells to nanobioelectronic transistors. Tremendous progress has been made on these research frontiers over the last twenty years. Yet, our fundamental understanding of CT in organic and biological semiconductors (OBS) that could rationalise experimental observations and guide further advances in the field is still very limited. These mater",{"id":813,"funder":7,"programme":8,"title":814,"piName":10,"institution":142,"country":143,"year":13,"amount":815,"abstract":816},"cordis-european-research-council-award-681295","Bacterial cooperation at the individual cell level","€1,994,981","All levels of life entail cooperation and conflict. Genes cooperate to build up a functional genome, which can yet be undermined by selfish genetic elements. Humans and animals cooperate to build up societies, which can yet be subverted by cheats. There is a long-standing interest among biologists to comprehend the tug-of-war between cooperation and conflict. Recently, research on bacteria was successful in identifying key factors that can tip the balance in favour or against cooperation. Bacter",{"id":818,"funder":7,"programme":8,"title":819,"piName":10,"institution":820,"country":39,"year":13,"amount":10,"abstract":821},"cordis-european-research-council-award-682626","Migrant Life Course and Legal Status Transition","EUROPEAN UNIVERSITY INSTITUTE","When does citizenship provide a boost to migrant integration? A fast-track to citizenship can maximise the potential for settlement success, though too short a pathway can disincentivise integration. Not all migrants have an equal interest in naturalising and some are discouraged by restrictive policies. Yet little is known about why, how and for whom legal status transition matters and, especially, how policy variation impacts on this relation. Which migrants are most discouraged by stricter re",{"id":823,"funder":7,"programme":8,"title":824,"piName":10,"institution":825,"country":62,"year":13,"amount":826,"abstract":827},"cordis-european-research-council-award-682724","Antiresonant Hollow Optical Fibres for a Quantum Leap in Data and Optical Power Transmission","UNIVERSITY OF SOUTHAMPTON","€2,749,639","Fibre optics has revolutionised telecommunications, enabled the widespread diffusion of the internet and profoundly impacted industrial manufacturing, metrology, medical endoscopy and structural sensing, to name but a few. In many applications however, fibres are now being operated very close to fundamental physical limits of the glass that forms their core, and this is already providing hard limits, for example, to the maximum data capacity or optical intensity that can be transmitted through t",{"id":829,"funder":7,"programme":8,"title":830,"piName":10,"institution":831,"country":32,"year":13,"amount":832,"abstract":833},"cordis-european-research-council-award-681450","Evolution of herbivory in vertebrates: developing combined isotope (Ca, Sr) and dental surface texture analysis as deep time diet proxies","JOHANNES GUTENBERG-UNIVERSITAT MAINZ","€1,728,065","Diet is a key factor driving vertebrate evolution. Exploring dietary traits and trophic relationships in fossil food webs is fundamental for understanding radiation and extinction events. This project aims to constrain the evolution of herbivory (plant feeding) and trophic interaction of extinct vertebrates at different spatiotemporal scales by analysing their teeth with isotopic and dental wear techniques. A new approach of combined Ca and stable Sr isotope as well as 3D surface texture (3DST) ",{"id":835,"funder":7,"programme":8,"title":836,"piName":10,"institution":443,"country":32,"year":13,"amount":68,"abstract":837},"cordis-european-research-council-award-681207","Groups, Dynamics, and Approximation","Eversince, the study of symmetry in mathematics and mathematical physics has been fundamentalto a thourough understanding of most of the fundamental notions. Group theory in all its formsis the theory of symmetry and thus an indispensible tool in many of the basic theoretical sciences.The study of infinite symmetry groups is especially challenging, since most of the tools from thesophisticated theory of finite groups break down and new global methods of study have to be found.In that respect, th",{"id":839,"funder":7,"programme":8,"title":840,"piName":10,"institution":467,"country":126,"year":13,"amount":841,"abstract":842},"cordis-european-research-council-award-682022","Middlebrow Enlightenment: Disseminating Ideas, Authors, and Texts in 18th-century Europe","€1,998,125","Intellectual history has long focused on a small number of authors and conceptual frameworks in studying societal change during the Enlightenment. Historians of the book have similarly restricted their vision, tending to privilege radical, subversive or forbidden texts. Yet ever since Daniel Mornet launched the history of the book approach a century ago, historians have recognized that it was authors who were not radical or subversive who produced the best-selling texts of the 18th century. This",{"id":844,"funder":7,"programme":8,"title":845,"piName":10,"institution":443,"country":32,"year":13,"amount":846,"abstract":847},"cordis-european-research-council-award-647051","The tiny and the fast: the role of subcortical sensory structures in human communication","€1,999,625","In Europe, approximately one hundred million people are impaired in their communication abilities. These include people with autism spectrum disorders (ca. 3 million) and individuals with dyslexia (ca. 50 million). Current neuroscience research typically associates cognitive functions including communication abilities with the cerebral cortex. By and large, this approach ignores the complex subcortical processing machinery before sensory signals reach the cortex. However, recent pioneering studi",{"id":849,"funder":7,"programme":8,"title":850,"piName":10,"institution":851,"country":126,"year":13,"amount":852,"abstract":853},"cordis-european-research-council-award-683076","Nanoscale Chemical Reactions Studied with In-Situ Transmission Electron Microscopy","UNIVERSITEIT UTRECHT","€1,996,250","Great successes have been achieved in nanoscience where the development of functional properties and the assembly of nanostructures into nanomaterials have become increasingly important. In general, both the tuning of the chemical and physical properties and the self-assembly of nanocrystals into 2D or 3D superstructures take place in a liquid environment. When analysing the structural properties of nanocrystals using Transmission Electron Microscopy (TEM), this liquid environment is contained b",{"id":855,"funder":7,"programme":8,"title":856,"piName":10,"institution":461,"country":62,"year":13,"amount":857,"abstract":858},"cordis-european-research-council-award-682285","Quantum Gas in a Box","€1,943,753","Ultracold atomic gases offer flexible systems for fundamental studies of both equilibrium and non-equilibrium many-body problems that are relevant across many fields, from condensed matter physics to high-energy physics and astrophysics. In the long run, research on these systems could also lead to practical applications, in the development of novel materials, force sensing, navigation, and quantum information processing. Traditionally, an important difference between conventional many-body syst",{"id":860,"funder":7,"programme":8,"title":861,"piName":10,"institution":728,"country":62,"year":13,"amount":862,"abstract":863},"cordis-european-research-council-award-647272","Perspectival Realism. Science, Knowledge, and Truth from a Human Vantage Point","€1,606,155","This project develops a novel view in philosophy of science called perspectival realism, via a three-pronged highly interdisciplinary approach, which combines the philosophy of science, with scientific practice, the history of science and the history of philosophy. Scientific perspectivism has recently attracted a great deal of attention for its ability to account for the perspectival nature of modelling, pervasive in the physical sciences, the life sciences, and the social sciences. Can scienti",{"id":865,"funder":7,"programme":8,"title":866,"piName":10,"institution":867,"country":32,"year":13,"amount":868,"abstract":869},"cordis-european-research-council-award-682841","Astrophysics with Stored Highy Charged Radionuclides","GSI HELMHOLTZZENTRUM FUR SCHWERIONENFORSCHUNG GMBH","€1,874,750","The main goal of ASTRUm is to employ stored and cooled radioactive ions for forefront nuclear astrophysics research. Four key experiments are proposed to be conducted at GSI in Darmstadt, which holds the only facility to date capable of storing highly charged radionuclides in the required element and energy range. The proposed experiments can hardly be conducted by any other technique or method.The weak decay matrix element for the transition between the 2.3 keV state in 205Pb and the ground sta",{"id":871,"funder":7,"programme":8,"title":872,"piName":10,"institution":431,"country":25,"year":13,"amount":873,"abstract":874},"cordis-european-research-council-award-682110","Policy, practice and patient experience in the age of intensified data sourcing","€1,972,860","The European healthcare services have begun collecting tissue samples and healthcare data from patients on an unprecedented scale. With POLICYAID we suggest the term 'intensified data sourcing' to describe these attempts at getting more data, on more people, of better quality while simultaneously making the data available for multiple uses. Data are used for research, for financial remuneration purposes, for quality assurance, to attract capital and even for police work. POLICYAID investigates h",{"id":876,"funder":7,"programme":8,"title":877,"piName":10,"institution":878,"country":879,"year":13,"amount":880,"abstract":881},"cordis-european-research-council-award-646663","Nucleotide Excision Repair: Decoding its Functional Role in Mammals","IDRYMA TECHNOLOGIAS KAI EREVNAS","EL","€1,995,000","Genome maintenance, chromatin remodelling and transcription are tightly linked biological processes that are currently poorly understood and vastly unexplored. Nucleotide excision repair (NER) is a major DNA repair pathway that mammalian cells employ to maintain their genome intact and faithfully transmit it into their progeny. Besides cancer and aging, however, defects in NER give rise to developmental disorders whose clinical heterogeneity and varying severity can only insufficiently be explai",{"id":883,"funder":7,"programme":8,"title":884,"piName":10,"institution":414,"country":396,"year":13,"amount":885,"abstract":886},"cordis-european-research-council-award-681870","Tracking the Dynamics of Human Metabolism using Spectroscopy-Integrated Liver-on-Chip Microdevices","€2,118,175","The liver is the main organ responsible for the systemic regulation of human metabolism, responding to hormonal stimulation, nutritional challenges, and circadian rhythms using fast enzymatic processes and slow transcriptional mechanisms. This regulatory complexity limits our ability to create efficient pharmaceutical interventions for metabolic diseases such as fatty liver disease and diabetes. In addition, circadian changes in drug metabolism can impact pharmacokinetics and pharmacodynamics af",{"id":888,"funder":7,"programme":8,"title":889,"piName":10,"institution":890,"country":32,"year":13,"amount":891,"abstract":892},"cordis-european-research-council-award-648521","Next-generation in vivo models for improved pancreatic cancer therapies","KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)","€2,440,275","Maintenance and drug resistance of pancreatic ductal adenocarcioma (PDAC) depends on cancer cell intrinsic mechanisms and a stroma that supports tumor growth. Mouse models of human PDAC have provided important insights into the evolution of this highly lethal tumor, but there are no models that allow secondary genetic manipulation of autochthonous tumors, the tumor microenvironment or the metastatic host niche once the tumor has formed.We generated an inducible dual-recombinase system by combini",{"id":894,"funder":7,"programme":8,"title":895,"piName":10,"institution":734,"country":62,"year":13,"amount":896,"abstract":897},"cordis-european-research-council-award-682417","Frontiers in Mechanism Design: Methodology and Applications","€1,644,774","Mechanism design is the engineering side of economics. Research findings in this field have helped governments and practitioners worldwide design better institutions: auctions that are more profitable or efficient; labour markets that improve the match between employees and employers; and better ways to assign students to public schools.  The cornerstone of mechanism design is the revelation principle, which provides a canonical class of mechanisms and turns the mechanism-selection problem (whic",{"id":899,"funder":7,"programme":8,"title":900,"piName":10,"institution":431,"country":25,"year":13,"amount":68,"abstract":901},"cordis-european-research-council-award-681396","Exploring and exploiting the potential of extinct genome sequencing","Palaeogenomics is the nascent discipline concerned with sequencing and analysis of genome-scale information from historic, ancient, and even extinct samples. While once inconceivable due to the challenges of DNA damage, contamination, and the technical limitations of PCR-based Sanger sequencing, following the dawn of the second-generation sequencing revolution, it has rapidly become a reality. Indeed, so much so, that popular perception has moved away from if extinct species’ genomes can be sequ",{"id":903,"funder":7,"programme":8,"title":904,"piName":10,"institution":905,"country":32,"year":13,"amount":10,"abstract":906},"cordis-european-research-council-award-682843","Electron-lattice-spin correlations and many-body phenomena in 2D semiconductors and related heterostructures","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","Two-dimensional crystalline materials exhibit exceptional physical properties and offer fascinating potential as fundamental building blocks for future two-dimensional electronic and optoelectronic devices.  Transition metal dichalcogenides (TMDCs) are of particular interest as they show a variety of many-body phenomena and correlation effects. Key properties are: i) additional internal degrees of freedom of the electrons, described as valley pseudospin and layer pseudospin, ii) electronic many-",{"id":908,"funder":7,"programme":8,"title":909,"piName":10,"institution":910,"country":32,"year":13,"amount":68,"abstract":911},"cordis-european-research-council-award-681577","Cellular substrate of abnormal network maturation in neuropsychiatric disorders","UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF","The long-lasting burden of major neuropsychiatric disorders results from disruption of cognitive performance in daily life. Impairment of long-range coupling between prefrontal cortex and hippocampus represents the substrate of disease-specific mnemonic and executive deficits. While it has been hypothesized that this impairment emerges long before the first clinical symptoms, technical and ethical limitations of non-invasive investigations in high-risk infants precluded the elucidation of ontoge",{"id":913,"funder":7,"programme":8,"title":914,"piName":10,"institution":414,"country":396,"year":13,"amount":286,"abstract":915},"cordis-european-research-council-award-647989","Rounding the circle: Unravelling the biogenesis, function and mechanism of action of circRNAs in the Drosophila brain.","Tight regulation of RNA metabolism is essential for normal brain function. This includes co and post-transcriptional regulation, which are extremely prevalent in neurons. Recently, circular RNAs (circRNAs), a highly abundant new type of regulatory non-coding RNA have been found across the animal kingdom. Two of these RNAs have been shown to act as miRNA sponges but no function is known for the thousands of other circRNAs, indicating the existence of a widespread layer of previously unknown gene ",{"id":917,"funder":7,"programme":8,"title":918,"piName":10,"institution":919,"country":62,"year":13,"amount":920,"abstract":921},"cordis-european-research-council-award-681582","Regulation of DNA interstrand crosslink repair by ubiquitin.","UNIVERSITY OF GLASGOW","€1,999,998","The overall objective of this proposal is to understand, on an atomic level, the mechanism of activation and regulation of the Fanconi Anemia (FA) DNA repair pathway. Homozygous mutations in the FA pathway lead to Fanconi Anemia, a devastating childhood genome instability disorder, typified by bone marrow failure and a high predisposition to cancers. The FA pathway is required for the repair of DNA interstrand crosslinks (ICLs), the hallmark of many cancers and FA. ICL repair is poorly understoo",{"id":923,"funder":7,"programme":8,"title":924,"piName":10,"institution":395,"country":396,"year":13,"amount":68,"abstract":925},"cordis-european-research-council-award-681352","Neural basis of natural navigation: Representation of goals, 3-D spaces and 1-km distances in the bat hippocampal formation – the role of experience","The mammalian hippocampal formation contains place cells, grid cells, head-direction cells and border cells, which collectively represent the animal’s position (‘map’), distance traveled (‘odometer’) and direction (‘compass’), and are thought to underlie navigation.  These neurons are typically studied in rodents running on linear tracks or in small empty boxes, ~1×1 m in size.  However, real-world navigation differs dramatically from typical laboratory setups, in at least three ways – which we ",{"id":927,"funder":7,"programme":8,"title":928,"piName":10,"institution":929,"country":32,"year":13,"amount":880,"abstract":930},"cordis-european-research-council-award-683300","Output-Sensitive Algorithms for Reactive Synthesis","CISPA - HELMHOLTZ-ZENTRUM FUR INFORMATIONSSICHERHEIT GGMBH","Reactive synthesis has the potential to revolutionize the development of distributed embedded systems. From a given logical specification, the synthesis algorithm automatically constructs an implementation that is correct-by-design. The vision is that a designer analyzes the design objectives with a synthesis tool, automatically identifies competing or contradictory requirements and obtains an error-free prototype implementation. Coding and testing, the most expensive stages of development, are ",{"id":932,"funder":7,"programme":8,"title":933,"piName":10,"institution":934,"country":94,"year":13,"amount":68,"abstract":935},"cordis-european-research-council-award-681840","Light-Driven Asymmetric Organocatalysis","FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA","Visible light photocatalysis and metal-free organocatalytic processes are powerful strategies of modern chemical research with extraordinary potential for the sustainable preparation of organic molecules. However, these environmentally respectful approaches have to date remained largely unrelated. The proposed research seeks to merge these fields of molecule activation to redefine their synthetic potential. Light-driven processes considerably enrich the modern synthetic repertoire, offering a po",{"id":937,"funder":7,"programme":8,"title":938,"piName":10,"institution":615,"country":62,"year":13,"amount":939,"abstract":940},"cordis-european-research-council-award-682393","Accretion, Winds, and Evolution of Spins and Magnetism of Stars","€2,206,205","This project focuses on Sun-like stars, which possess convective envelopes and universally exhibit magnetic activity (in the mass range 0.1 to 1.3 MSun). The rotation of these stars influences their internal structure, energy and chemical transport, and magnetic field generation, as well as their external magnetic activity and environmental interactions. Due to the huge range of timescales, spatial scales, and physics involved, understanding how each of these processes relate to each other and t",{"id":942,"funder":7,"programme":8,"title":943,"piName":10,"institution":402,"country":126,"year":13,"amount":944,"abstract":945},"cordis-european-research-council-award-681466","TIME FOR A CHANGE:  An out-of-the-box approach to unravel transitions in depression","€1,994,076","Major Depression (MD) is often chronic and characterized by frequent recurrences of symptoms and burden. The need to better understand how and when relevant transitions in symptoms occur is urgent. A seemingly unsolvable scientific problem is the enormous etiological complexity of mental disorders such as MD, involving continuously ongoing gene-environment interactions that act in highly person-specific ways. This hampers accurate assessment of personalized risk. I will use an out-of-the-box and",{"id":947,"funder":7,"programme":8,"title":948,"piName":10,"institution":949,"country":425,"year":13,"amount":950,"abstract":951},"cordis-european-research-council-award-681707","The nonlinear high energy regime of Quantum Chromodynamics","JYVASKYLAN YLIOPISTO","€1,935,000","This proposal concentrates on Quantum Chromodynamics (QCD) in its least well  understood final frontier: the high energy limit. The aim is to treat the formation of quark gluon plasma in relativistic nuclear collisions together with other high energy processes in a consistent QCD framework.  This project is topical now in order to fully understand the results from the maturing LHC heavy ion program. The high energy regime is characterized by a high density of gluons, whose nonlinear interactions",{"id":953,"funder":7,"programme":8,"title":954,"piName":10,"institution":604,"country":126,"year":13,"amount":10,"abstract":955},"cordis-european-research-council-award-681663","Worlds of Imagination. A Comparative Study of Film Tourism in India, Brazil, Jamaica,  South Korea and the United Kingdom.","This research project focuses on film tourism: the phenomenon of people visiting locations from popular films or TV series. Recent years have seen a dramatic, worldwide increase of this type of tourism, with far-reaching implications for the experience and organization of landscapes. While the number of empirical studies on film tourism is growing, most have been limited to isolated, Western examples. This Western focus tends to overlook the fact that the face of the media industry as well as th",{"id":957,"funder":7,"programme":8,"title":958,"piName":10,"institution":959,"country":586,"year":13,"amount":68,"abstract":960},"cordis-european-research-council-award-682537","Boundary value problems for nonlinear integrable equations","KUNGLIGA TEKNISKA HOEGSKOLAN","The purpose of this project is to develop new methods for solving boundary value problems (BVPs) for nonlinear integrable partial differential equations (PDEs). Integrable PDEs can be analyzed by means of the Inverse Scattering Transform, whose introduction was one of the most important developments in the theory of nonlinear PDEs in the 20th century. Until the 1990s the inverse scattering methodology was pursued almost entirely for pure initial-value problems. However, in many laboratory and fi",{"id":962,"funder":7,"programme":8,"title":963,"piName":10,"institution":910,"country":32,"year":13,"amount":964,"abstract":965},"cordis-european-research-council-award-648131","Novel multimodal approach to atrial fibrillation risk assessment and identification of targets for prevention by interdisciplinary exploitation of omics, advanced electrocardiography, and imaging","€1,999,305","There is a growing need for novel risk schemes in atrial fibrillation (AF) to permit prevention, contribute to a better understanding of the pathophysiology, and discover targets for individualized treatment.Primary prevention efforts are scant despite the imminent AF epidemic. In international cohorts I have developed and validated the first risk prediction algorithm. However, it explains only 60% of the attributable risk and efforts at improving discrimination are urgently required.Therefore, ",{"id":967,"funder":7,"programme":8,"title":968,"piName":10,"institution":969,"country":32,"year":13,"amount":970,"abstract":971},"cordis-european-research-council-award-682899","Mechanism and Consequences of the Interplay between Mitosis and Human Papillomavirus Initial Infection","UNIVERSITAET MUENSTER","€1,868,993","Human Papillomavirus Type 16 (HPV16), the paradigm cancer-causing HPV type, is a small, nonenveloped, DNA virus characterized by its complex life cycle coupled to differentiation of squamous epithelia. Due to this complexity, how HPV16 infects cells is an understudied field of research. Our previous work to define the cellular pathways that are hijacked for initial infection revealed uptake by a novel endocytosis mechanism, and the requirement for mitosis for nuclear delivery. Our findings indic",{"id":973,"funder":7,"programme":8,"title":974,"piName":10,"institution":38,"country":39,"year":13,"amount":68,"abstract":975},"cordis-european-research-council-award-681647","Enhanced NeUtrino BEams from kaon Tagging","ENUBET has been designed to open a new window of opportunities in accelerator neutrino physics.  The proposed project enables for the first time the measurement of the positrons produced in the decay tunnel of conventional neutrino beams: these particles signal uniquely the generation of an electron neutrino at source. Neutrino facilities enhanced by the ENUBET technique will have an unprecedented control of the neutrino flux. This will allow to reduce by one order of magnitude the uncertainties",{"id":977,"funder":7,"programme":8,"title":978,"piName":10,"institution":979,"country":396,"year":13,"amount":980,"abstract":981},"cordis-european-research-council-award-682676","Going Beyond the WIMP: From Theory to Detection of Light Dark Matter","TEL AVIV UNIVERSITY","€1,822,083","The identity of dark matter (DM) is still unknown. For more than three decades, significant theoretical and experimental efforts have been directed towards the search for a Weakly Interacting Massive Particle (WIMP), often overlooking other possibilities. The lack of an unambiguous positive signal, at indirect- and direct-detection experiments and at the LHC, stresses the need to expand on other theoretical possibilities, and more importantly, to develop new experimental capabilities. Indeed it ",{"id":983,"funder":7,"programme":8,"title":984,"piName":10,"institution":985,"country":39,"year":13,"amount":986,"abstract":987},"cordis-european-research-council-award-682190","Mechanisms and regulators coordinating replication integrity and DNA damage tolerance.","IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS","€1,991,250","Accurate chromosomal DNA replication is of fundamental importance for cellular function, genome integrity and development. In response to replication perturbations, DNA damage response (DDR) and DNA damage tolerance (DDT) pathways become activated and are crucial for detection and tolerance of lesions, as well as for facilitating replication completion and supporting chromosome structural integrity. While important functions and key players of these regulatory processes have been outlined, much ",{"id":989,"funder":7,"programme":8,"title":990,"piName":10,"institution":991,"country":126,"year":13,"amount":992,"abstract":993},"cordis-european-research-council-award-682467","Moralising Misfortune: A comparative anthropology of commercial insurance","UNIVERSITEIT LEIDEN","€1,807,334","This is a study of the morality of commercial life insurance. What moral issues are raised when commercial companies define responsibilities for misfortune and the appropriateness of entitlements? What are the concerns about the financialization of life and intimacy?First, this study examines the morality of bureaucratic classifications produced by the insurance industry. Classifications reveal particular perspectives on the world and are at the heart of defining the risks covered by life insura",{"id":995,"funder":7,"programme":8,"title":996,"piName":10,"institution":949,"country":425,"year":13,"amount":997,"abstract":998},"cordis-european-research-council-award-682779","Epistemic Transitions in Islamic Philosophy, Theology and Science: From the 12th to the 19th Century","€1,526,429","Not very long ago, it was still common to hold that little of interest took place in Islamic philosophy, theology and science after the death of the Peripatetic commentator Averroes in 1198. Recent research has produced increasing evidence against this view, and experts now commonly agree that texts from the so-called post-classical period merit serious analysis. That evidence, however, is still fragmentary, and we lack a clear understanding of the large scale and long run development in the var",{"id":1000,"funder":7,"programme":8,"title":1001,"piName":10,"institution":1002,"country":32,"year":13,"amount":1003,"abstract":1004},"cordis-european-research-council-award-682711","A study of weaving as technical mode of existence","DEUTSCHES MUSEUM VON MEISTERWERKEN DER NATURWISSENSCHAFT UND TECHNIK","€1,943,771","The PENELOPE project builds on the hypothesis that there was a significant but tacit contribution of textile technology involved in the advent of science in ancient Greece. Bruno Latour recently claimed that technologies require an original mode of existence that accounts for their particular form of detour. I agree and propose the technological labyrinth of threads in weaving as a paradigm for this mode. In contrast to the well-known but insufficient idea of hylemorphism (a form\u002Fidea applied to",{"id":1006,"funder":7,"programme":8,"title":1007,"piName":10,"institution":728,"country":62,"year":13,"amount":1008,"abstract":1009},"cordis-european-research-council-award-681942","The evolution of linguistic complexity","€1,985,570","Human language is unique among the communication systems of the natural world, providing our species with an incredibly flexible and powerful open-ended system of communication. This expressive power is underpinned by linguistic structure: we construct complex meaning-bearing utterances according to a set of rules and regularities which are conventionalised among speakers of a language. In my previous work I have shown that these fundamental structural features of language can be explained as a ",{"id":1011,"funder":7,"programme":8,"title":1012,"piName":10,"institution":1013,"country":488,"year":13,"amount":1014,"abstract":1015},"cordis-european-research-council-award-682181","Understanding small RNA-mediated transposon control at the level of chromatin in the animal germline","INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH","€1,999,530","Transposable elements—universal components of genomes—pose a major threat to genome integrity due to their mutagenic character. In all eukaryotic lineages small RNA pathways act as defense systems to protect the host genome against the activity of transposons. The central pathway in animals is the gonad-specific PIWI interacting RNA (piRNA) pathway, one of the most elaborate but also least understood small RNA silencing systems.Here I propose to study the interplay between the piRNA pathway and ",{"id":1017,"funder":7,"programme":8,"title":1018,"piName":10,"institution":1019,"country":32,"year":13,"amount":1020,"abstract":1021},"cordis-european-research-council-award-681012","Understanding the dynamics of the immune system to cure graft-versus-host disease (GvHD).","UNIVERSITAETSKLINIKUM FREIBURG","€1,987,500","Acute graft-versus-host disease (GvHD) is the leading cause of the high mortality of patients having undergone allogeneic hematopoietic cell transplantation. A key event in the pathogenesis of GvHD is the injury and loss of epithelial cells in the intestinal tract. The overall goal of GvHDCure is to identify the pathophysiological mechanisms that initiate (1), propagate (2) and maintain (3) GvHD. (1) We found that one of the earliest events during GvHD initiation is infiltration of the intestine",{"id":1023,"funder":7,"programme":8,"title":1024,"piName":10,"institution":461,"country":62,"year":13,"amount":1025,"abstract":1026},"cordis-european-research-council-award-683211","New level of theoretical precision for LHC Run 2 and beyond","€1,713,983","LHC Run 2 will operate at significantly higher centre of mass energy and could offer an unprecedented insight into the largely unexplored region of TeV physics. The usefulness of this wealth of forthcoming high-quality data would, however, be strongly dependent on the availability of theoretical predictions with matching accuracy. The current state of the art for hadron collider calculations is NNLO and calculations for the most interesting 2-to-2 processes have already been performed. The utili",{"id":1028,"funder":7,"programme":8,"title":1029,"piName":10,"institution":890,"country":32,"year":13,"amount":1030,"abstract":1031},"cordis-european-research-council-award-682435","Post-transcriptional Regulation of Germinal Center B Cell Responses in Immunity and Disease","€1,998,066","Antibodies secreted by B cells of the adaptive immune system establish an essential barrier against bacteria and viruses and their presence is the hallmark of protective vaccinations. B cells are licensed for their tasks during germinal center (GC) reactions and differentiation into antibody-secreting plasma cells. Unfortunately, B cell-derived autoantibodies and proinflammatory cytokines can cause or contribute to autoimmune diseases.While major transcription factor networks regulating protecti",{"id":1033,"funder":7,"programme":8,"title":1034,"piName":10,"institution":1035,"country":62,"year":13,"amount":10,"abstract":1036},"cordis-european-research-council-award-680958","The New Shape of Family-Related Gender Stratification","UNIVERSITY OF BATH","A mountain of evidence fails to account for gender inequalities in employment, earnings and unpaid work predicted by partnership and parenthood, leading scholars to deem the hoped-for gender equality revolution “stalled.” We argue the revolution continues, but pockets of progress are only located when unpacking within-gender differences in effects at individual, couple, and employer levels. This research advances state-of-the-art by revealing how sources and outcomes of gender inequalities predi",{"id":1038,"funder":7,"programme":8,"title":1039,"piName":10,"institution":851,"country":126,"year":13,"amount":1040,"abstract":1041},"cordis-european-research-council-award-647737","Digital Crossings in Europe: Gender, Diaspora and Belonging","€1,992,809","Many immigrants enter Europe both legally and illegally every year. This creates multiple challenges for the Union, including the gender and ethnic segregation of migrant groups, especially women. While it strives for an inclusive and integrated society as envisioned by the EU motto ‘Unity in Diversity’, it is still often perceived more as ‘Fortress Europe.’ This project focuses on the ‘connected migrant’, studying how virtual communities of migrants, or digital diasporas, convey issues of techn",{"id":1043,"funder":7,"programme":8,"title":1044,"piName":10,"institution":615,"country":62,"year":13,"amount":1045,"abstract":1046},"cordis-european-research-council-award-680951","Recombination, sex-specific adaptation and evolution of the poeciliid sex chromosomes","€1,999,665","Sex chromosomes have evolved independently countless times throughout the eukaryotes. As such, sex chromosomes represent one of the most pervasive examples of convergent evolution, as analogous yet unrelated sex chromosomes share many unique features that distinguish them from the rest of the genome. Although models for sex chromosome evolution have been proposed, they have been difficult to empirically test, largely because most model systems are at a terminal phase of sex chromosome divergence",{"id":1048,"funder":7,"programme":8,"title":1049,"piName":10,"institution":1050,"country":383,"year":13,"amount":68,"abstract":1051},"cordis-european-research-council-award-681872","Automatic Design of Robot Swarms","UNIVERSITE LIBRE DE BRUXELLES","The scope of this project is the automatic design of robot swarms. Swarm robotics is an appealing approach to the  coordination of large groups of robots. Up to now, robot swarms have been designed via some labor-intensive process.My goal is to advance the state of the art in swarm robotics by developing the DEMIURGE: an intelligent system that is able to design and realize robot swarms in a totally integrated and automatic wayThe DEMIURGE is a novel concept. Starting from requirements expressed",{"id":1053,"funder":7,"programme":8,"title":1054,"piName":10,"institution":1055,"country":62,"year":13,"amount":450,"abstract":1056},"cordis-european-research-council-award-682451","Sexual Humanitarianism: understanding agency and exploitation in the global sex industry","KINGSTON UNIVERSITY HIGHER EDUCATION CORPORATION","The humanitarian fight against trafficking in the sex industry legitimizes the enforcement of increasingly restrictive migration laws and controls, which often exacerbate sex workers’ vulnerability to being trafficked. SEXHUM adopts an art-science interdisciplinary approach bringing together visual anthropology, sociology, gender and queer studies and human geography to study the relationship between migration, sex work, exploitation and trafficking. It contextualizes this relationship within th",{"id":1058,"funder":7,"programme":8,"title":1059,"piName":10,"institution":461,"country":62,"year":13,"amount":1060,"abstract":1061},"cordis-european-research-council-award-682833","Semi-Artificial Photosynthesis with Wired Enzymes","€1,960,289","Nature has been harnessing solar energy to drive endergonic life-sustaining reactions such as photosynthesis for billions of years. However, the overall biological processes are inefficient despite the evolution of efficient enzymes for carrying out specific reactions. Currently, there is an urgent need to develop superior strategies for the large scale conversion of solar energy into a renewable chemical fuel through artificial photosynthesis, which uses the same fundamental science as natural ",{"id":1063,"funder":7,"programme":8,"title":1064,"piName":10,"institution":1065,"country":32,"year":13,"amount":1066,"abstract":1067},"cordis-european-research-council-award-681917","Ultrafast spin transport and magnetic order controlled by terahertz electromagnetic pulses","FREIE UNIVERSITAET BERLIN","€1,984,375","In order to fully exploit the electron spin as a signal carrier in future information processing, spins need to be transported and flipped as fast as possible. Spintronics research aims at implementing these operations by electric fields in circuitry, but has so far been limited to frequencies below ~10 GHz. The much faster complementary femtomagnetism approach employs femtosecond laser pulses (carrier frequency ~400 THz), but is not compatible with microelectronics technology.In the TERAMAG pro",{"id":1069,"funder":7,"programme":8,"title":1070,"piName":10,"institution":419,"country":143,"year":13,"amount":1071,"abstract":1072},"cordis-european-research-council-award-681178","Mechanisms of RNA-guided genome editing in eukaryotes","€1,953,000","The goal of this project is to contribute to our understanding of RNA-mediated epigenetic mechanisms of genome regulation in eukaryotes. Ciliated protozoa offer a fantastic opportunity to investigate the complex process of trans-generational programming of chromosomal rearrangements, which is thought to serve as a form of immune defense against invasive DNA. Developmental processes in ciliates include extensive rearrangements of the germline DNA, including elimination of transposons and the prec",{"id":1074,"funder":7,"programme":8,"title":1075,"piName":10,"institution":1076,"country":62,"year":13,"amount":1077,"abstract":1078},"cordis-european-research-council-award-682253","Consequences of out-group conflict","UNIVERSITY OF BRISTOL","€1,971,866","The aim of this project is to determine the proximate and ultimate consequences of a fundamental but neglected aspect of sociality: out-group conflict. In a wide range of social species, from ants to humans, group members invest considerable defensive effort against individual intruders and rival groups. The lasting impacts of these conflicts with conspecifics are poorly understood. I will integrate empirical and theoretical approaches to uncover the effect of out-group conflict on: (i) individu",{"id":1080,"funder":7,"programme":8,"title":1081,"piName":10,"institution":710,"country":32,"year":13,"amount":1082,"abstract":1083},"cordis-european-research-council-award-646669","Endoscopic Comprehensive Optical Multimodal Molecular Intelligent Imaging","€1,998,530","Optical imaging has exceptional potential for medical diagnosis, because it can provide high spatial resolution and molecular contrast. However, for in vivo imaging in humans, the poor penetration of only a few millimetres is a major obstacle. Optical endoscopes solve this problem, but currently most of them only perform non-advanced, classical white light imaging. Also, the speed of current devices is not sufficient to comprehensively scan entire organs at microscopic resolution. Hence, medical",{"id":1085,"funder":7,"programme":8,"title":1086,"piName":10,"institution":1087,"country":1088,"year":13,"amount":1089,"abstract":1090},"cordis-european-research-council-award-681443","CRACKING THE CODE BEHIND MITOTIC FIDELITY: the roles of tubulin post-translational modifications and a chromosome separation checkpoint","INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC","PT","€2,323,468","During the human lifetime 10000 trillion cell divisions take place to ensure tissue homeostasis and several vital functions in the organism. Mitosis is the process that ensures that dividing cells preserve the chromosome number of their progenitors, while deviation from this, a condition known as aneuploidy, represents the most common feature in human cancers. Here we will test two original concepts with strong implications for chromosome segregation fidelity. The first concept is based on the “",{"id":1092,"funder":7,"programme":8,"title":1093,"piName":10,"institution":1094,"country":126,"year":13,"amount":1095,"abstract":1096},"cordis-european-research-council-award-648082","Social Cognition in Adolescents: Brain Networks and Social Networks","STICHTING VU","€1,998,655","The forming of social bonds is an evolutionary imperative, and a rich target for empirical research. Social scientists have scrutinized the structure of the elaborate social networks that characterize today’s society. Neuroscientists have elucidated the brain mechanisms underlying our ability to navigate this social world. Yet, these research lines have been largely separated. This proposal aims to integrate social network research and social brain research, focusing on adolescence as the most d",200,{"programme":8,"total":1099,"withPiName":1100,"firstYear":1101,"lastYear":1102,"countryCount":1103,"perYear":1104,"topInstitutions":1144,"topCountries":1213},4499,349,2014,2027,45,[1105,1107,1110,1112,1115,1118,1121,1124,1127,1130,1133,1136,1139,1142],{"year":1101,"count":1106},303,{"year":1108,"count":1109},2015,335,{"year":13,"count":1111},322,{"year":1113,"count":1114},2017,327,{"year":1116,"count":1117},2018,403,{"year":1119,"count":1120},2019,300,{"year":1122,"count":1123},2020,277,{"year":1125,"count":1126},2021,321,{"year":1128,"count":1129},2022,364,{"year":1131,"count":1132},2023,359,{"year":1134,"count":1135},2024,366,{"year":1137,"count":1138},2025,375,{"year":1140,"count":1141},2026,416,{"year":1102,"count":1143},31,[1145,1148,1151,1154,1157,1160,1163,1165,1167,1170,1172,1175,1178,1180,1182,1185,1188,1191,1194,1197,1199,1202,1205,1208,1211],{"name":1146,"count":1147},"Centre National de la Recherche Scientifique CNRS",229,{"name":1149,"count":1150},"University of Oxford",89,{"name":1152,"count":1153},"Weizmann Institute of Science",78,{"name":1155,"count":1156},"University of Cambridge",77,{"name":1158,"count":1159},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",63,{"name":1161,"count":1162},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",55,{"name":1164,"count":1162},"Institut National de la Sante Et de la Recherche Medicale",{"name":1166,"count":1162},"Kobenhavns Universitet",{"name":1168,"count":1169},"Universiteit Utrecht",51,{"name":1171,"count":1169},"University College London",{"name":1173,"count":1174},"Tel Aviv University",49,{"name":1176,"count":1177},"The Hebrew University of Jerusalem",43,{"name":1179,"count":1177},"Universiteit Gent",{"name":1181,"count":1177},"Universiteit van Amsterdam",{"name":1183,"count":1184},"Ludwig-Maximilians-Universitaet Muenchen",42,{"name":1186,"count":1187},"Technische Universitaet Muenchen",41,{"name":1189,"count":1190},"Eidgenoessische Technische Hochschule Zuerich",40,{"name":1192,"count":1193},"Universitat Wien",39,{"name":1195,"count":1196},"Helsingin Yliopisto",38,{"name":1198,"count":1196},"Technische Universiteit Delft",{"name":1200,"count":1201},"Katholieke Universiteit Leuven",37,{"name":1203,"count":1204},"Universitetet I Oslo",36,{"name":1206,"count":1207},"École Polytechnique Fédérale de Lausanne",34,{"name":1209,"count":1210},"The University of Edinburgh",32,{"name":1212,"count":1143},"Lunds Universitet",[1214,1216,1218,1220,1222,1224,1226,1228,1229,1231,1233,1235,1237,1239,1241,1243,1245,1248,1249,1252,1254,1257,1259,1261,1264],{"name":32,"count":1215},810,{"name":62,"count":1217},559,{"name":12,"count":1219},490,{"name":126,"count":1221},428,{"name":94,"count":1223},315,{"name":39,"count":1225},267,{"name":396,"count":1227},219,{"name":143,"count":1097},{"name":586,"count":1230},170,{"name":383,"count":1232},166,{"name":488,"count":1234},146,{"name":25,"count":1236},127,{"name":425,"count":1238},94,{"name":329,"count":1240},85,{"name":345,"count":1242},82,{"name":1088,"count":1244},68,{"name":1246,"count":1247},"GB",47,{"name":799,"count":1204},{"name":1250,"count":1251},"HU",24,{"name":879,"count":1253},22,{"name":1255,"count":1256},"US",21,{"name":752,"count":1258},20,{"name":593,"count":1260},14,{"name":1262,"count":1263},"LU",13,{"name":1265,"count":1266},"EE",8]