[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-consolidator-grant-2018":3,"awarded-stats-erc-consolidator-grant":1125},{"awarded":4,"total":1124},[5,16,22,29,36,42,48,54,60,65,72,78,83,89,96,102,107,113,119,125,131,137,144,150,155,161,168,173,179,184,190,195,200,205,211,217,222,227,232,237,242,247,252,259,264,268,274,278,284,289,295,302,308,313,317,323,328,333,337,342,348,353,358,363,368,373,378,384,390,396,402,408,414,421,427,434,440,445,451,457,463,469,474,479,486,492,498,503,509,515,522,527,532,537,542,548,553,557,563,568,574,580,585,590,596,602,607,613,619,624,630,635,641,647,652,657,662,668,674,679,684,689,694,700,706,712,718,724,730,737,742,747,753,759,765,771,776,782,788,794,800,806,812,818,824,829,835,842,848,853,859,864,869,875,880,886,891,897,903,908,913,918,923,928,934,940,946,951,957,962,967,973,978,983,988,993,998,1004,1010,1015,1019,1025,1029,1034,1040,1047,1052,1057,1062,1067,1071,1076,1082,1086,1091,1097,1103,1108,1114,1119],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-european-research-council-award-erc-2014-cog-648916-","European Research Council","ERC Consolidator Grant","Maternal depression during pregnancy and cord blood DNA methylation: findings from the Avon Longitudinal Study of Parents and Children","Anne‐Cathrine Finnemann Viuff","Aarhus University","DK",2018,null,"Up to 13% of women may experience symptoms of depression during pregnancy or in the postpartum period. Depression during pregnancy has been associated with an increased risk of adverse neurodevelopmental outcomes in the child and epigenetic mechanisms could be one of the biological pathways to explain this association. In 844 mother-child pairs from the Avon Longitudinal Study of Parents and Children, we carried out an epigenome-wide association study (EWAS) to investigate associations between p",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":21,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2013-cog-617-329","Influence of temporal data aggregation on trend estimation for intense rainfall","Renato Morbidelli","University of Perugia","IT",{"id":23,"funder":7,"programme":8,"title":24,"piName":25,"institution":26,"country":27,"year":13,"amount":14,"abstract":28},"openalex-european-research-council-award-erc-cog-616179","New Insights From Pre-Columbian Land Use and Fire Management in Amazonian Dark Earth Forests","S. Yoshi Maezumi","University of Exeter","GB","Anthropogenic climate change driven by increased carbon emissions is leading to more severe fire seasons and increasing the frequency of mega-fires in the Amazon. This has the potential to convert Amazon forests from net carbon sinks to net carbon sources. Although modern human influence over the Earth is substantial, debate remains over when humans began to dominate Earth’s natural systems. To date, little is known about the history of human land use in key regions like the Amazon. Here, we exa",{"id":30,"funder":7,"programme":8,"title":31,"piName":32,"institution":33,"country":34,"year":13,"amount":14,"abstract":35},"openalex-european-research-council-award-erc-2013-cog","Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions","Eugenio F. Fornasiero","Universitätsmedizin Göttingen","DE","The turnover of brain proteins is critical for organism survival, and its perturbations are linked to pathology. Nevertheless, protein lifetimes have been difficult to obtain in vivo. They are readily measured in vitro by feeding cells with isotopically labeled amino acids, followed by mass spectrometry analyses. In vivo proteins are generated from at least two sources: labeled amino acids from the diet, and non-labeled amino acids from the degradation of pre-existing proteins. This renders meas",{"id":37,"funder":7,"programme":8,"title":38,"piName":39,"institution":40,"country":27,"year":13,"amount":14,"abstract":41},"openalex-european-research-council-award-erc-consolidator-grant-erc-2013-cog","“I Have Been Formed in This Revolution”: Revolution as Infrastructure, and The People It Creates in Cuba","Martin Holbraad","University College London","How do revolutions form persons? Based on nine months of ethnographic fieldwork in Havana (2015-17), this article takes as its point of departure the trajectory of a middle-aged woman's involvement with state structures and institutions during the course of constructing the house in which she lives. Describing ethnographically the ways in which these state involvements intertwine with other areas of her life, I suggest that this woman's sense of having been \"formed in the revolution\" is owed par",{"id":43,"funder":7,"programme":8,"title":44,"piName":14,"institution":45,"country":21,"year":13,"amount":46,"abstract":47},"cordis-european-research-council-award-772261","Xene Fabrication for a Two-Dimensional Nanotechnology Platform","CONSIGLIO NAZIONALE DELLE RICERCHE","€1,998,785","Xenes denote two-dimensional (2D) monoelemental (X) crystals beyond graphene with a honeycomb lattice. Unlike graphene, Xenes do not exist in Nature, but they become stable via epitaxy on substrates. So far experimental evidences of Xene epitaxy have been reported for X=Si, Ge, Sn, B, P, and Sb (named silicene, germanene, stanene, borophene, phosphorene, and antimonene, respectively). Xene single layers also serve as a background for the synthesis of new Xene-related materials (XRMs) such as Xen",{"id":49,"funder":7,"programme":8,"title":50,"piName":14,"institution":51,"country":34,"year":13,"amount":52,"abstract":53},"cordis-european-research-council-award-770936","Newton strata - geometry and representations","UNIVERSITAET MUENSTER","€1,202,500","The Langlands programme is a far-reaching web of conjectural or proven correspondences joining the fields of representation theory and of number theory. It is one of the centerpieces of arithmetic geometry, and has in the past decades produced many spectacular breakthroughs, for example the proof of Fermat’s Last Theorem by Taylor and Wiles.The most successful approach to prove instances of Langlands’ conjectures is via algebraic geometry, by studying suitable moduli spaces such as Shimura varie",{"id":55,"funder":7,"programme":8,"title":56,"piName":14,"institution":57,"country":34,"year":13,"amount":58,"abstract":59},"cordis-european-research-council-award-771537","Dynamics of Correlated Quantum Matter: From Dynamical Probes to Novel Phases of Matter","TECHNISCHE UNIVERSITAET MUENCHEN","€1,998,750","The interplay of quantum fluctuations and correlation effects in condensed matter can yield emergent phases with fascinating properties. Understanding these challenging quantum-many body systems is a problem of central importance in theoretical physics and the basis for the development of new materials for future technologies. Dynamical properties can provide characteristic fingerprints that allow to identify novel phases in newly synthesized materials and optical lattice systems. Moreover, when",{"id":61,"funder":7,"programme":8,"title":62,"piName":14,"institution":57,"country":34,"year":13,"amount":63,"abstract":64},"cordis-european-research-council-award-771776","Cosmic Fireworks Première: Unravelling Enigmas of Type Ia Supernova Progenitor and Cosmology through Strong Lensing","€1,992,500","The LENSNOVA project proposes a breakthrough both in cosmology and stellar physics, capitalising on 10 years of experience in the field of strong lensing time delays. Type Ia supernovae (SNe Ia) can now be watched on prime seats through strong lensing, where multiple images of the same SN appear at different times\u002Flocations around a foreground lens galaxy. After the first SN appears, the next SN occurrence (of the same SN event) can be predicted and observed in its entirety for the first time in",{"id":66,"funder":7,"programme":8,"title":67,"piName":14,"institution":68,"country":69,"year":13,"amount":70,"abstract":71},"cordis-european-research-council-award-772487","supracellular contractility of myofibroblasts in gut homeostasis and cancer invasion","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","FR","€2,000,000","There has been tremendous progress in understanding the importance of the microenvironment and its chemical signals for homeostasis of stem cell niche in the intestine and for tumor invasion and metastasis formation in many different tissues. However, the way stromal cells such as myofibroblasts or cancer-associated fibroblasts (CAFs) use mechanical forces to shape the extracellular matrix and consequently dictate the response of epithelial cells remains unexplored at the single-cell level mainl",{"id":73,"funder":7,"programme":8,"title":74,"piName":14,"institution":75,"country":21,"year":13,"amount":76,"abstract":77},"cordis-european-research-council-award-770047","Printable Electronics on Paper through  2D materials based inks","UNIVERSITA DI PISA","€1,883,868","The vision behind the PEP2D project is to pioneer the realization of fully printed electronic circuits on flexible substrates as paper, leveraging the exceptional electronic properties of inks based on novel two- dimensional materials (2DMs), and through the wide-spread and low-cost inkjet printing technology.The development of fully printed electronic systems on flexible substrates as paper could have an unpreceded economical and societal impact on the European Union. Unleashing the potential o",{"id":79,"funder":7,"programme":8,"title":80,"piName":14,"institution":57,"country":34,"year":13,"amount":81,"abstract":82},"cordis-european-research-council-award-772473","Tailoring the functional Capacity of Cytotoxic T cells for future Therapies","€1,999,850","Cytotoxic T cells have enormous potential for prophylactic and therapeutic interventions against problematic acute or chronic infections and against malignant tumors. A major obstacle to utilizing them effectively is our limited understanding of the molecular foundation that is necessary for CD8 T cells to fulfil their pleiotropic functions. Equally important is to find solutions supporting the robust and safe induction of large numbers of pathogen- or tumor-specific T cells and strategies for c",{"id":84,"funder":7,"programme":8,"title":85,"piName":14,"institution":86,"country":34,"year":13,"amount":87,"abstract":88},"cordis-european-research-council-award-772646","Micro-Fat Tissue on Chip","HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH","€1,775,000","Human fat tissue has evolved to serve as a major energy reserve. An imbalance between energy intake and expenditure leads to an expansion of adipose tissue. Maintenance of this energy imbalance over longer times leads to obesity and metabolic disorders such as type 2 diabetes, for which clinical cures are not yet available. Adipocytes are the main cell type within the adipose tissue and can be divided into white, beige, and brown subtypes. White adipocytes store and mobilize energy, whereas beig",{"id":90,"funder":7,"programme":8,"title":91,"piName":14,"institution":92,"country":93,"year":13,"amount":94,"abstract":95},"cordis-european-research-council-award-772354","Justice Interactions and Peacebuilding:  From Static to Dynamic Discourses across National, Ethnic, Gender and Age Groups","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","UK","€1,976,260","JUSTINT will provide a novel way of analysing how post-conflict justice practices, such as war crimes trials and truth-seeking, advance or hinder peacebuilding. It breaks away radically from existing approaches and examines an interactive and dynamic aspect of discourse. Until now, we have relied on statements by politicians, civil society actors, or victims to understand their response to post-conflict justice, and studied them as static discourses. Instead, we need to investigate communicative",{"id":97,"funder":7,"programme":8,"title":98,"piName":14,"institution":99,"country":69,"year":13,"amount":100,"abstract":101},"cordis-european-research-council-award-772103","The function of membrane tethering in plant intercellular communication","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€1,999,840","Intercellular communication is critical for multicellularity. It coordinates the activities within individual cells to support the function of an organism as a whole. Plants have developed remarkable cellular machines -the Plasmodesmata (PD) pores- which interconnect every single cell within the plant body, establishing direct membrane and cytoplasmic continuity, a situation unique to plants. PD are indispensable for plant life. They control the flux of molecules between cells and are decisive f",{"id":103,"funder":7,"programme":8,"title":104,"piName":14,"institution":99,"country":69,"year":13,"amount":105,"abstract":106},"cordis-european-research-council-award-771369","Are marine living microorganisms influencing clouds?","€1,999,329","Earth, as a whole, can be considered as a living organism emitting gases and particles in its atmosphere, in order to regulate its own temperature (Lovelock, 1988). In particular oceans, which cover 70% of the Earth, may respond to climate change by emitting different species under different environmental conditions. At the global scale, a large fraction of the aerosol number concentration is formed by nucleation of low-volatility  gas-phase compounds, a process that is expected to ultimately de",{"id":108,"funder":7,"programme":8,"title":109,"piName":14,"institution":110,"country":111,"year":13,"amount":70,"abstract":112},"cordis-european-research-council-award-771486","Metabolic regulation of  metastatic growth","VIB VZW","BE","Metastatic growth of cancer cells requires extracellular matrix (ECM) production. The current understanding is that transcription factors regulate ECM production and thus metastatic growth by increasing the expression of collagen prolyl 4-hydroxylase (CP4H). In contrast, we recently discovered that metabolism regulates CP4H activity independently of the known transcription factors. Specifically, we found that loss of pyruvate metabolism inhibits CP4H activity and consequently ECM–dependent breas",{"id":114,"funder":7,"programme":8,"title":115,"piName":14,"institution":116,"country":117,"year":13,"amount":70,"abstract":118},"cordis-european-research-council-award-770854","An integrative approach for the exploration of melanoma genetic and immunological interactions","WEIZMANN INSTITUTE OF SCIENCE","IL","Tumor development emerges from an accumulation of somatic alterations that together enable malignant growth. These alterations are immensely diverse and the fate of a cell acquiring an alteration may depend on other alterations already present. Despite our progress in mapping the cancer genetic landscape and an expanding catalogue of cancer genes, a need arises to establish how alterations in cancer genes interact to transform healthy cells into cancer cells. Many fundamental questions regarding",{"id":120,"funder":7,"programme":8,"title":121,"piName":14,"institution":122,"country":123,"year":13,"amount":14,"abstract":124},"cordis-european-research-council-award-773051","FRontiers in dust minerAloGical coMposition and its Effects upoN climaTe","BARCELONA SUPERCOMPUTING CENTER CENTRO NACIONAL DE SUPERCOMPUTACION","ES","Soil dust aerosols are mixtures of different minerals, whose relative abundances, particle size distribution (PSD), shape, surface topography and mixing state influence their effect upon climate. However, Earth System Models typically assume that dust aerosols have a globally uniform composition, neglecting the known regional variations in the mineralogy of the sources. The goal of FRAGMENT is to understand and constrain the global mineralogical composition of dust along with its effects upon cl",{"id":126,"funder":7,"programme":8,"title":127,"piName":14,"institution":128,"country":129,"year":13,"amount":14,"abstract":130},"cordis-european-research-council-award-770765","Reining in the upper bound on Earth’s Climate Sensitivities","STOCKHOLMS UNIVERSITET","SE","One of the greatest recent advances in climate science is that it is now beyond reasonable doubt that human activity is warming the Earth. The next natural question is by how much the Earth will warm for a given emission – a quantity that will be essential to regulating global warming. Yet, the likely range of 1.5-4.5 K for equilibrium climate sensitivity (ECS) for a doubling of the atmospheric CO2 concentration has not been reduced for decades. In particular the risk of ECS being high is concer",{"id":132,"funder":7,"programme":8,"title":133,"piName":14,"institution":134,"country":69,"year":13,"amount":135,"abstract":136},"cordis-european-research-council-award-772408","Deconstructing the string landscape","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","€1,669,465","Despite its uniqueness, string theory has a “landscape” of low-energy solutions with very different observable physics. These solutions are usually found using low-energy effective theories which, in order to satisfy all the experimental constraints, require a number of exotic ingredients whose string theory origin is unclear. Thus, finding a solution within the effective theory compatible with experiments is far from the same as showing that such a solution is stable in string theory, to say no",{"id":138,"funder":7,"programme":8,"title":139,"piName":14,"institution":140,"country":141,"year":13,"amount":142,"abstract":143},"cordis-european-research-council-award-771620","The Climates and Habitability of Small Exoplanets Around Red Stars","UNIVERSITAET BERN","CH","€1,984,729","The detection of life beyond our Solar System is possible only via the remote sensing of the atmospheres of exoplanets.  The recent discovery that small exoplanets are common around cool, red stars offers an exciting opportunity to study the atmospheres of Earth-like worlds.  Motivated by this revelation, the EXOKLEIN project proposes to construct a holistic climate framework to understand astronomical observations in the context of the atmosphere, geochemistry and biosignatures of the exoplanet",{"id":145,"funder":7,"programme":8,"title":146,"piName":14,"institution":147,"country":93,"year":13,"amount":148,"abstract":149},"cordis-european-research-council-award-771586","MultiphasIc NanoreaCtors for HEterogeneous CataLysis via SmArt ENGinEering of TaiLored DispersiOns","CARDIFF UNIVERSITY","€1,956,720","Gas-liquid-solid (G\u002FL\u002FS) multiphasic reactors are extensively used in the chemical industry for catalytic processes. However, conventional reactors, such as packed beds and slurry reactors, typically suffer from resilient mass\u002Fheat transfer limitations due to their low specific interface areas, long mixing times, and a reduced accessibility of the gas reactants to the catalyst surface. To overcome these limitations, continuous flow microreactors and catalytic membrane reactors have been consider",{"id":151,"funder":7,"programme":8,"title":152,"piName":14,"institution":99,"country":69,"year":13,"amount":153,"abstract":154},"cordis-european-research-council-award-771850","Atomic-scale physics of single-photon sources.","€1,996,848","Single-photon sources (SPSs) are systems capable of emitting photons one by one. These sources are of major importance for quantum-information science and applications. SPSs experiments generally rely on the optical excitation of two level systems of atomic-scale dimensions (single-molecules, vacancies in diamond). Many fundamental questions related to the nature of these sources and the impact of their environment remain to be explored:Can SPSs be addressed with atomic-scale spatial accuracy? H",{"id":156,"funder":7,"programme":8,"title":157,"piName":14,"institution":158,"country":34,"year":13,"amount":159,"abstract":160},"cordis-european-research-council-award-771417","Quantum nonlinear optics through Rydberg interaction","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","€1,993,793","Optical photons, for all practical purposes, do not interact. This fundamental property of light forms the basis of modern optics and enables a multitude of technical applications in our every-day life, such as all-optical communication and microscopy. On the other hand, an engineered interaction between individual photons would allow the creation and control of light photon by photon, providing fundamental insights into the quantum nature of light and allowing us to harness non-classical states",{"id":162,"funder":7,"programme":8,"title":163,"piName":14,"institution":164,"country":165,"year":13,"amount":166,"abstract":167},"cordis-european-research-council-award-772253","Time-domain Gibbs sampling: From bits to inflationary gravitational waves","UNIVERSITETET I OSLO","NO","€1,999,205","The detection of primordial gravity waves created during the Big Bang ranks among the greatest potential intellectual achievements in modern science. During the last few decades, the instrumental progress necessary to achieve this has been nothing short of breathtaking, and we today are able to measure the microwave sky with better than one-in-a-million precision. However, from the latest ultra-sensitive experiments such as BICEP2 and Planck, it is clear that instrumental sensitivity alone will ",{"id":169,"funder":7,"programme":8,"title":170,"piName":14,"institution":99,"country":69,"year":13,"amount":171,"abstract":172},"cordis-european-research-council-award-771688","New Frontiers for Optoelectronics with Artificial Media","€1,965,045","To detect or generate complex light beams that are increasingly needed in biology and photonics (light with non-zero angular momentum and non-classical light), it is necessary to rely on bulky and sophisticated setups, considerably limiting their potential. The FORWARD project aims at obtaining the same functionalities with a new generation of optoelectronic components of submicron thickness in the near infrared range. This ambitious objective implies to devise radically new ways of creating and",{"id":174,"funder":7,"programme":8,"title":175,"piName":14,"institution":176,"country":21,"year":13,"amount":177,"abstract":178},"cordis-european-research-council-award-772953","Turning the cortically blind brain to see: from neural computations to system dynamics generating visual awareness in humans and monkeys","UNIVERSITA DEGLI STUDI DI TORINO","€1,994,212","Visual awareness affords flexibility and experiential richness, and its loss following brain damage has devastating effects. However, patients with blindness following cortical damage may retain visual functions, despite visual awareness is lacking (blindsight). But, how can we translate non-conscious visual abilities into conscious ones after damage to the visual cortex? To place our understanding of visual awareness on firm neurobiological and mechanistic bases, I propose to integrate human an",{"id":180,"funder":7,"programme":8,"title":181,"piName":14,"institution":92,"country":93,"year":13,"amount":182,"abstract":183},"cordis-european-research-council-award-772200","Institutions in Consumer Credit","€1,017,851","Whether (and why) the market for consumer credit is inefficient is still an open question with important implications for household well-being. The research in this proposal will study sources of inefficiencies in two burgeoning consumer credit institutions: high-cost credit and on-line marketplaces. Each institution serves borrowers on opposite ends of the wealth and credit risk spectrum. Thus, they provide an ideal laboratory for studying the wide range of economic frictions that shape the acc",{"id":185,"funder":7,"programme":8,"title":186,"piName":14,"institution":187,"country":93,"year":13,"amount":188,"abstract":189},"cordis-european-research-council-award-771736","Temporal structures of gender inequalities in Asian and Western welfare regimes","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€1,999,739","An important part of sociological understanding of how welfare regimes are shaped by culture and history derives from Esping-Andersen’s 'three worlds' account. But these worlds, and later developments in this field, including the extension and application of the framework to gender roles, derive exclusively from Western models. What will emerge as we seek to develop a global perspective on other models of welfare regimes and how they handle gender inequalities? We will answer this question, usin",{"id":191,"funder":7,"programme":8,"title":192,"piName":14,"institution":99,"country":69,"year":13,"amount":193,"abstract":194},"cordis-european-research-council-award-770933","NanoOptoMechanics in classical and quantum Liquids","€2,292,068","Over a decade, the field of optomechanics has progressed to the point of enabling first quantum experiments on mesoscopic mechanical devices. This maturity culminates with nanoscale semiconductor systems, which operate at very high mechanical frequency and allow intense interaction between light and mechanical motion. On top of representing a new class of elementary quantum systems, nano-optomechanical devices can sense forces at small scale with high speed and resolution, down to the quantum li",{"id":196,"funder":7,"programme":8,"title":197,"piName":14,"institution":134,"country":69,"year":13,"amount":198,"abstract":199},"cordis-european-research-council-award-771599","Exploration below the tip of the microtubule","€1,998,227","Microtubules (MTs) are dynamic cytoskeleton filaments. They permanently transit between growth and shrinkage. This famous “dynamic instability” is governed by the addition and loss of tubulin dimers at their tips. In contrast to the tip, the MT lattice was considered to be a passive structure supporting intracellular transport. However, we recently found that MT lattice is dynamic and active! Actually, tubulin dimers can be exchanged with the cytoplasmic pool along the entire length of the MT. T",{"id":201,"funder":7,"programme":8,"title":202,"piName":14,"institution":99,"country":69,"year":13,"amount":203,"abstract":204},"cordis-european-research-council-award-771589","Debate: Innovation as Performance in Late-Medieval Universities","€1,997,976","The switch from parchment to paper had a fundamental impact on later medieval universities, equivalent to the shift to Open Access today, hindering some intellectual practices while encouraging others. The DEBATE project identifies a neglected genre of latin texts that flourished on paper, the Principia, which record the public confrontations between candidates (socii) for the title of doctor. These debates, imposed by university statutes throughout Europe as annual exercises linked to lectures ",{"id":206,"funder":7,"programme":8,"title":207,"piName":14,"institution":208,"country":21,"year":13,"amount":209,"abstract":210},"cordis-european-research-council-award-773202","Tuned to the Rhythm: How Prenatally and Postnatally Heard Speech Prosody Lays the Foundations for Language Learning","UNIVERSITA DEGLI STUDI DI PADOVA","€1,621,250","The role of experience in language acquisition has been the focus of heated theoretical debates, between proponents of nativist views according to whom experience plays a minimal role and advocates of empiricist positions holding that experience, be it linguistic, social or other, is sufficient to account for language acquisition. Despite more than a half century of dedicated research efforts, the problem is not solved. The present project brings a novel perspective to this debate, combining hit",{"id":212,"funder":7,"programme":8,"title":213,"piName":14,"institution":214,"country":34,"year":13,"amount":215,"abstract":216},"cordis-european-research-council-award-773248","Terahertz Waveform Synthesis and Analysis Using Hybrid Photonic-Electronic Circuits","KARLSRUHER INSTITUT FUER TECHNOLOGIE","€2,498,954","Generation, detection, and processing of electromagnetic waveforms is one the most important tech-nical foundations of modern society. Digital signal processing, in particular, has revolutionized many areas of science and engineering. By exploiting massively parallel processing with tens of billions of transistors at comparatively low internal clock speed, CMOS circuits can provide output data rates of hundreds of gigabit per second, corresponding to effective clock rates of several hundred GHz.",{"id":218,"funder":7,"programme":8,"title":219,"piName":14,"institution":187,"country":93,"year":13,"amount":220,"abstract":221},"cordis-european-research-council-award-724180","Control and measurement of single macromolecules in space and time","€2,124,965","The desire to “freely suspend the constituents of matter” in order to study their behaviour can be traced back over 200 years to Lichtenberg’s diaries. From radio-frequency ion traps to optical tweezing of colloidal particles, existing methods to trap matter in free space or solution rely on the use of external fields that often strongly perturb the integrity of a macromolecule in solution. Recently, I invented the ‘electrostatic fluidic trap’, a “field-free” principle that supports stable, non-",{"id":223,"funder":7,"programme":8,"title":224,"piName":14,"institution":92,"country":93,"year":13,"amount":225,"abstract":226},"cordis-european-research-council-award-771004","Empirical Analyses of Markets for Consumer Financial Products and their Effects","€1,550,945","This proposal presents three broad projects on information frictions in households' credit markets and on theconsequences of these frictions for durable good markets. Specifically, an influential theoretical literature ininformation economics has shown that borrowing constraints can arise in equilibrium when borrowers andlenders have asymmetric information about borrowers' risks. Hence, the first project aims to provide the firstempirical analyses of markets (i.e., demand and supply) with asymme",{"id":228,"funder":7,"programme":8,"title":229,"piName":14,"institution":51,"country":34,"year":13,"amount":230,"abstract":231},"cordis-european-research-council-award-772249","The Black Hole Stability Problem and the Analysis of asymptotically anti-de Sitter spacetimes","€1,999,755","The present proposal is concerned with the analysis of the Einstein equations of general relativity, a non-linear system of geometric partial differential equations describing phenomena from the bending of light to the dynamics of black holes. The theory has recently been confirmed in a spectacular fashion with the detection of gravitational waves.The main objective of the proposal is to consolidate my research group based at Imperial College by developing novel mathematical techniques that will",{"id":233,"funder":7,"programme":8,"title":234,"piName":14,"institution":99,"country":69,"year":13,"amount":235,"abstract":236},"cordis-european-research-council-award-773228","An iono-electronic neuromorphic interface for communication with living systems","€1,898,520","While our understanding of the brain have made huge progresses, we are still inefficient in interfacing biological systems with electronics, both in terms of energy and integration potential. Pushed by the need to use conventional computers for building complex systems dedicated to brain interface applications, we have mostly capitalized on technologies and architectures inherits from microelectronic that are intrinsically not adapted to interface living systems. The IONOS project will shift the",{"id":238,"funder":7,"programme":8,"title":239,"piName":14,"institution":99,"country":69,"year":13,"amount":240,"abstract":241},"cordis-european-research-council-award-771453","Drafting and Enacting the Revolutions in the Arab Mediterranean. In search of Dignity, from the 1950’s until today","€1,941,050","DREAM, Drafting and Enacting the Revolutions in the Arab Mediterranean, seeks to write the history of the revolutions in the Arab Mediterranean since the independences. It aims to write a transnational history of often forgotten struggles, recall facts and original forms of resistance. We know very few about the revolts that occurred in this period, and even less about the memory that they left in the societies, the way these memories circulated. This rediscovery of revolutions in the shadows mu",{"id":243,"funder":7,"programme":8,"title":244,"piName":14,"institution":99,"country":69,"year":13,"amount":245,"abstract":246},"cordis-european-research-council-award-772873","Advanced and Reusable Theory for the In Silico-optimization of composite electrode fabrication processes for rechargeable battery Technologies with Innovative Chemistries","€1,976,445","The aim of this project is to develop and to demonstrate a novel theoretical framework devoted to rationalizing the formulation of composite electrodes containing next-generation material chemistries for high energy density secondary batteries. The framework will be established through the combination of discrete particle and continuum mathematical models within a multiscale computational workflow integrating the individual models and mimicking the different steps along the electrode fabrication",{"id":248,"funder":7,"programme":8,"title":249,"piName":14,"institution":99,"country":69,"year":13,"amount":250,"abstract":251},"cordis-european-research-council-award-771829","Nanoassemblies for the subcutaneous self-administration of anticancer drugs","€1,759,414","To counter the predicted drastic rise of new cancer cases over the next decades and to lower the dramatic financial burden of cancer treatments on patients and healthcare systems, innovative chemotherapies with high efficacy and reduced cost represent an urgent and unmet clinical need. Despite great enthusiasm for drug-loaded anticancer nanocarriers (e.g., liposomes, nanoparticles, micelles), their bench-to-bedside translation is not straightforward. Recent disappointments during clinical trials",{"id":253,"funder":7,"programme":8,"title":254,"piName":14,"institution":255,"country":256,"year":13,"amount":257,"abstract":258},"cordis-european-research-council-award-772627","Quantum networks wired by multi-spin entanglement","TECHNISCHE UNIVERSITEIT DELFT","NL","€1,625,000","Entanglement is arguably the most defining and yet counterintuitive feature of quantum theory. The non-local nature of entanglement provides exciting opportunities for fundamentally new science and technologies. As a prime example, recent theoretical work has uncovered the unique potential of a future quantum network: a network of nodes consisting of multiple well-controlled quantum particles “wired” by quantum entanglement. Such a network would enable distributed quantum computing and simulatio",{"id":260,"funder":7,"programme":8,"title":261,"piName":14,"institution":262,"country":256,"year":13,"amount":70,"abstract":263},"cordis-european-research-council-award-772564","Morphogenesis of photo-mechanized molecular materials","RIJKSUNIVERSITEIT GRONINGEN","The sophistication reached by organic chemistry has enabled the design and synthesis of a wide range of dynamic molecules that display controlled shape changes with an ever-increasing refinement. However, amplifying these molecular-scale dynamics to support shape-transformation in a broad range of macroscopic functions remains a key challenge.To address this challenge, I draw inspiration from living materials where molecular machines maintain out of equilibrium states by ingenious coupling with ",{"id":265,"funder":7,"programme":8,"title":266,"piName":14,"institution":99,"country":69,"year":13,"amount":14,"abstract":267},"cordis-european-research-council-award-772743","Socio-Semantic Bubbles of Internet Communities","SOCSEMICS aims at developing a set of integrated, groundbreaking methods to address the possible existence of so-called “filter bubbles” in the digital public space. In all generality, this phenomenon may be construed as communities whose actors are more or less prone to interaction and open to informations coming from “outside” of these communities. SOCSEMICS will contribute to the formalization and operationalization of this question by addressing three current challenges: (i) developing a com",{"id":269,"funder":7,"programme":8,"title":270,"piName":14,"institution":271,"country":21,"year":13,"amount":272,"abstract":273},"cordis-european-research-council-award-772293","Galactic archeology with high temporal resolution","ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA","€1,958,863","The Milky Way is a complex system, with dynamical and chemical substructures, where several competing processes such as mergers, internal secular evolution, gas accretion and gas flows take place. To study in detail how such a giant spiral galaxy was formed and evolved, we need to reconstruct the sequence of its main formation events with high (~10%) temporal resolution. Asterochronometry will determine accurate, precise ages for tens of thousands of stars in the Galaxy. We will take an approach",{"id":275,"funder":7,"programme":8,"title":276,"piName":14,"institution":99,"country":69,"year":13,"amount":14,"abstract":277},"cordis-european-research-council-award-770826","Dynamics of eco-evolutionary systems","Evolutionary and ecological processes can affect one another. For example, adaptation can affect population dynamics or species interactions in communities, and thus ecosystem functioning. Eco-evolutionary systems show periods of both stability and of sudden change, but the following general hypotheses for the causes of these complex dynamics are largely untested in natural settings. First, eco-evolutionary systems are thought to be governed by feedback loops, with positive feedback promoting ra",{"id":279,"funder":7,"programme":8,"title":280,"piName":14,"institution":281,"country":123,"year":13,"amount":282,"abstract":283},"cordis-european-research-council-award-772268","The Implications of Selective Information Sampling for Individual and Collective Judgments","UNIVERSIDAD POMPEU FABRA","€1,158,625","Much research has shown that judgments are the products of imperfect information processing heuristics. Recently, an alternative theoretical perspective has been proposed. It emphasizes that people form judgments by observing information samples about the alternatives. Sampling-based theories can explain numerous judgment patterns such as risk aversion, overconfidence, illusory correlations, the in-group out-group bias, or social influence.The sampling approach has illustrated how these and othe",{"id":285,"funder":7,"programme":8,"title":286,"piName":14,"institution":99,"country":69,"year":13,"amount":287,"abstract":288},"cordis-european-research-council-award-772204","Mechanochemistry: a unique opportunity for oxygen isotopic labelling and NMR spectroscopy","€1,999,836","Oxygen is an element of major importance, due to its presence in the vast majority of molecules and materials. Over the years, much effort has been put into the development of analytical techniques allowing the study of oxygen environments, in view of elucidating key questions about the structure and reactivity of a variety of systems. In this context, Nuclear Magnetic Resonance (NMR) spectroscopy has been the focus of much attention, because it has progressively emerged as a technique capable o",{"id":290,"funder":7,"programme":8,"title":291,"piName":14,"institution":292,"country":93,"year":13,"amount":293,"abstract":294},"cordis-european-research-council-award-724880","Global Firms and Global Value Chains: Measurement and Mechanisms","UNIVERSITY COLLEGE LONDON","€1,462,304","The growing fragmentation of production across firms and countries has revolutionized international trade in recent decades. Firms today choose which production stages to conduct themselves and which to outsource to other parties, which to complete at home and which to offshore abroad. Known as global value chains (GVCs), this phenomenon creates new challenges and opportunities for individual firms and aggregate economies. Of primary policy interest are the implications of GVCs for growth, the t",{"id":296,"funder":7,"programme":8,"title":297,"piName":14,"institution":298,"country":299,"year":13,"amount":300,"abstract":301},"cordis-european-research-council-award-770769","Investigating nutrients as key determinants of DC-induced CD8 T cell responses","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","IE","€1,995,861","A new immunoregulatory axis has emerged in recent years demonstrating that cellular metabolism is crucial in controlling immune responses. This regulatory axis is acutely sensitive to nutrients that fuel metabolic pathways and support nutrient sensitive signalling pathways. My recent research demonstrates that nutrients are dynamically controlled and are not equally available to all immune cells. The data shows that activated T cells, clustered around a dendritic cell (DC), can consume the avail",{"id":303,"funder":7,"programme":8,"title":304,"piName":14,"institution":305,"country":93,"year":13,"amount":306,"abstract":307},"cordis-european-research-council-award-772798","Biotechnology for investigating cell fate choice","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€1,876,618","The evolution from a stem cell to differentiated progeny underpins tissue development and homeostasis, which are driven by a multitude of cell fate choices. The transitions underlying these choices are not well understood. There are a number of challenges that must be overcome to achieve this understanding. In the proposed research we will tackle two of the challenges: first, the dynamics of fate choices, i.e. the dependence of transitions on time and inductive signals, remains cryptic; second, ",{"id":309,"funder":7,"programme":8,"title":310,"piName":14,"institution":99,"country":69,"year":13,"amount":311,"abstract":312},"cordis-european-research-council-award-772786","Stroke diagnostic imaging performed with ultrafast ultrasound localization microscopy (uULM)","€1,995,098","Each year, stroke kills 6 million people worldwide and permanently disable another 5 million. The prognosis is defined by the extent of the stroke, along with the rapidity by which it is identified and treated. Current diagnostic imaging, MRI and CT, require specialized centers and time. Even though ultrasound could provide a rapid and portable diagnostic tool, it is currently constrained by diffraction, which yield a theoretically incompressible compromise between the penetration in depth and t",{"id":314,"funder":7,"programme":8,"title":315,"piName":14,"institution":164,"country":165,"year":13,"amount":14,"abstract":316},"cordis-european-research-council-award-771355","Set to change: early life factors restricting and promoting neurocognitive plasticity through life","Cognitive function in old age can be predicted from how you functioned when you were young. This is remarkable, as there are substantial cognitive age changes. Are we neurodevelopmentally set to change through life in certain ways? The objective of Set-to-change is to test whether and how early life environmental factors and genetic makeup interact to regulate neurocognitive plasticity through the lifespan. Neurocognitive plasticity; i.e. changes in brain and cognition in response to environment",{"id":318,"funder":7,"programme":8,"title":319,"piName":14,"institution":320,"country":93,"year":13,"amount":321,"abstract":322},"cordis-european-research-council-award-772080","Acoustic-Flow Interaction Models for Advancing Thermoacoustic Instability prediction in Very low Emission combustors","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€1,985,288","Gas turbines are an essential ingredient in the long-term energy and aviation mix. They are flexible, offer fast start-up and the ability to burn renewable-generated fuels. However, they generate NOx emissions, which cause air pollution and damage human health, and reducing these is an air quality imperative. A major hurdle to this is that lean premixed combustion, essential for further NOx emission reductions, is highly susceptible to thermoacoustic instability. This is caused by a two-way coup",{"id":324,"funder":7,"programme":8,"title":325,"piName":14,"institution":187,"country":93,"year":13,"amount":326,"abstract":327},"cordis-european-research-council-award-771997","Handmade: Understanding Creative Gesture in Pottery Making","€1,889,292","Human beings have always relied on the skills of the hand for exploring their creative potential. The process of making by hand lies at the intersection between embodied cognition and material culture – linking the plasticity of the brain to the incredibly variety of bodily techniques, materials and forms of material culture. Still, the full creative dimensions of this process as well as the changing relationship of the human hand with past and present material culture are not well understood an",{"id":329,"funder":7,"programme":8,"title":330,"piName":14,"institution":331,"country":69,"year":13,"amount":14,"abstract":332},"cordis-european-research-council-award-771294","Accounting for Metallicity, Polarization of the Electrolyte, and Redox reactions in computational Electrochemistry","SORBONNE UNIVERSITE","Applied electrochemistry plays a key role in many technologies, such as batteries, fuel cells, supercapacitors or solar cells. It is therefore at the core of many research programs all over the world. Yet, fundamental electrochemical investigations remain scarce. In particular, electrochemistry is among the fields for which the gap between theory and experiment is the largest. From the computational point of view, there is no molecular dynamics (MD) software devoted to the simulation of electroc",{"id":334,"funder":7,"programme":8,"title":335,"piName":14,"institution":214,"country":34,"year":13,"amount":14,"abstract":336},"cordis-european-research-council-award-771237","Deformation Mechanisms are the Key to Understanding and Tayloring Tribological Behaviour","Tribology, the science of interacting surfaces in relative motion, is crucial for many aspects of modern life. Friction and wear decisively impact the lifetime and durability of many products-from nanoelectromechanical systems to gears and engines. In the USA alone, an estimated 1E18 joules of energy could be saved each year through improved tribological practices.During sliding of a metallic contact, a mutated surface layer forms, carries most further plastic deformation and largely determines ",{"id":338,"funder":7,"programme":8,"title":339,"piName":14,"institution":92,"country":93,"year":13,"amount":340,"abstract":341},"cordis-european-research-council-award-770839","PARENTAL TIME INVESTMENTS AND INTERGENERATIONAL TRANSMISSION OF INEQUALITY","€1,960,098","High socio-economic status parents consistently produce high socio-economic status children. The question is how. The objective of PARENTIME is to develop new socio-economic theories that unpack the detailed mechanisms driving the inter-generational transmission of inequality.Because of data limitations and theoretical traditions, the literature has focused on a narrow conceptualization of parental time (limited to the quantity of time spent with children in different kinds of activities), and a",{"id":343,"funder":7,"programme":8,"title":344,"piName":14,"institution":345,"country":21,"year":13,"amount":346,"abstract":347},"cordis-european-research-council-award-772970","Agent-Based Modelling of Gene Networks to model clonal selection in the tumour microenvironment and predict therapeutic resistance","UNIVERSITA COMMERCIALE LUIGI BOCCONI","€1,996,325","The occurrence of therapeutic resistance is a major cause for the small effect on overall survival showed by targeted cancer therapies. Whilst experimental strategies to evaluate available treatments have been faced by an ever increasing number of possible combinations, computational approaches have been challenged by the lack of a framework able to model the multiple interactions encompassed by the three major factors affecting therapeutic resistance: selection of resistant clones, adaptability",{"id":349,"funder":7,"programme":8,"title":350,"piName":14,"institution":99,"country":69,"year":13,"amount":351,"abstract":352},"cordis-european-research-council-award-771965","Transport and Receptor Mechanisms of Human Solute Carriers","€2,050,125","Human solute carriers (hSLC) form a superfamily of integral membrane proteins that transport small molecules and ions across membranes, and their transport functions are essential to processes ranging from synaptic transmission to apoptosis. Moreover, some hSLCs are the cellular receptors of human and pathogenic proteins, and play important roles in organogenesis, as well as infectious diseases.The hSLC transport and receptor functions are involved in a wide range of pathological conditions, whi",{"id":354,"funder":7,"programme":8,"title":355,"piName":14,"institution":281,"country":123,"year":13,"amount":356,"abstract":357},"cordis-european-research-council-award-770958","The Causal Effect of Public Policy and Income on Child Health and Human Capital","€1,048,750","A recent literature in economics on the “fetal origins hypothesis” has documented that a range of early (prenatal and postnatal) shocks and interventions can have substantial effects on long-term human capital formation (e.g. adult health, wages). However, we still know little about the years in between early infancy and adulthood, referred to as the “missing middle”. How do early shocks affect health and human capital formation during childhood? How do the effects of different types of interven",{"id":359,"funder":7,"programme":8,"title":360,"piName":14,"institution":99,"country":69,"year":13,"amount":361,"abstract":362},"cordis-european-research-council-award-772191","Multiphysics study of the dynamics, resistance and targeted therapy potential of deformable Micro-Capsules","€1,999,470","Encapsulation consists in enclosing an internal medium in a solid semi-permeable membrane to protect it and control the exchanges with the environment. Being at the source of innovative applications in the fields of biotechnologies, pharmacology, energy storage and food industry, capsules offer tremendous potential in the process engineering world. But scientific challenges remain to be met, such as finding the optimal compromise between payload and membrane thickness, characterizing the membran",{"id":364,"funder":7,"programme":8,"title":365,"piName":14,"institution":271,"country":21,"year":13,"amount":366,"abstract":367},"cordis-european-research-council-award-771127","INvention of SCRIpts and their BEginnings","€1,463,337","Writing must rank among mankind’s highest achievements. Yet the factors that enabled its invention independently in different parts of the world have never been subject to an analysis from a multidisciplinary and comparative perspective that encompasses both deciphered and undeciphered scripts. INSCRIBE takes such an approach, combining a study of the world’s first instances of writing, including the earliest in Europe, through the lens of archaeology, anthropology, cultural evolution, cognitive",{"id":369,"funder":7,"programme":8,"title":370,"piName":14,"institution":187,"country":93,"year":13,"amount":371,"abstract":372},"cordis-european-research-council-award-771047","Qur'anic Commentary: An Integrative Paradigm","€1,777,962","QuCIP will deliver the first historical-critical commentary on a sizable portion of the Qur’an in English, covering the three longest and most complex compositions in the Islamic scripture, surahs 2–4, as well as the short opening surah 1. The project will thereby put forward a pioneering proof of concept for an integrative exegetical approach capable of addressing three core dimensions of the Qur’an: the compositional structure of Qur’anic texts, the intricate processes of literary growth and r",{"id":374,"funder":7,"programme":8,"title":375,"piName":14,"institution":187,"country":93,"year":13,"amount":376,"abstract":377},"cordis-european-research-council-award-771575","Nanoengineering and Processing of Metal-Organic Framework Composites for Photonic Sensors","€2,431,911","The project is in the field of nanoporous materials engineering, focusing on the discovery, characterisation and application of metal-organic frameworks (MOFs) as an innovative platform to afford disruptive photonics sensing technology. Compared to the traditional material options (e.g. metal oxides and nitrides), MOFs offer several key advantages. The vast inorganic-organic (hybrid) structural diversity of MOFs implies a huge prospect to tune the desirable physical and chemical properties for e",{"id":379,"funder":7,"programme":8,"title":380,"piName":14,"institution":381,"country":21,"year":13,"amount":382,"abstract":383},"cordis-european-research-council-award-772284","Reconstructing community dynamics and ecosystem functioning after glacial retreat","UNIVERSITA DEGLI STUDI DI MILANO","€1,845,773","Glaciers show a pattern of retreat at the global scale. Increasing areas are exposed and colonized by multiple organisms, but lack of global studies hampers a complete understanding of the future of recently deglaciated terrains. What will be the fate of these areas? How do animals, plants and microorganisms colonize them? How do they interact to perform successful colonization? Which are the climatic, geological and biogeographical processes determining colonization patterns? How does ecosystem",{"id":385,"funder":7,"programme":8,"title":386,"piName":14,"institution":387,"country":34,"year":13,"amount":388,"abstract":389},"cordis-european-research-council-award-771859","Cloud-cloud interaction in convective precipitation","LEIBNIZ-ZENTRUM FUR MARINE TROPENFORSCHUNG (ZMT) GMBH","€1,314,800","State-of-the-art simulations and observations highlight the self-organization of convective clouds. Our recent work shows two aspects: these clouds are capable of unexpected increase in extreme precipitation when temperature rises",{"id":391,"funder":7,"programme":8,"title":392,"piName":14,"institution":393,"country":34,"year":13,"amount":394,"abstract":395},"cordis-european-research-council-award-726276","antiProton Unstable Matter Annihilation","TECHNISCHE UNIVERSITAT DARMSTADT","€2,548,298","One of the most fascinating quantum phenomena in nuclear physics is the occurrence of neutron halos and neutron skins in very neutron rich atomic nuclei. Thick neutron skins and halos, not yet evidenced in medium mass nuclei, would be unique low-density neutron matter accessible in the laboratory. Nuclear shell structure is also known to change with the number of protons and neutrons. The nuclear structure of very heavy nuclei at and above Z=100 is barely known, and the existence of new long-liv",{"id":397,"funder":7,"programme":8,"title":398,"piName":14,"institution":399,"country":123,"year":13,"amount":400,"abstract":401},"cordis-european-research-council-award-772331","Current Tools and Policy Challenges in Electricity Markets","UNIVERSIDAD CARLOS III DE MADRID","€1,422,375","The fight against climate change is among Europe’s top policy priorities. In this research agenda, I propose to push out the frontier in the area of Energy and Environmental Economics by carrying out policy-relevant research on a pressing issue: how to design optimal regulatory and market-based solutions to achieve a least cost transition towards a low-carbon economy. The European experience provides unique natural experiments with which to test some of the most contentious issues that arise in ",{"id":403,"funder":7,"programme":8,"title":404,"piName":14,"institution":405,"country":34,"year":13,"amount":406,"abstract":407},"cordis-european-research-council-award-769065","Cell-free reconstitution of autophagy to dissect molecular mechanisms","UNIVERSITAETSKLINIKUM FREIBURG","€1,955,666","Autophagy, a lysosomal degradation pathway in which the cell digests its own components, is an essential biological pathway that promotes organismal health and longevity and helps combat cancer and neurodegenerative diseases. Accordingly, the 2016 Nobel Prize in Physiology or Medicine was awarded for research in autophagy. Although autophagy has been extensively studied from yeast to mammals, the molecular events that underlie its induction and progression remain elusive. A highly conserved prot",{"id":409,"funder":7,"programme":8,"title":410,"piName":14,"institution":411,"country":141,"year":13,"amount":412,"abstract":413},"cordis-european-research-council-award-772190","Discovery and molecular investigation of mycobacterial transporters responsible for iron acquisition","UNIVERSITAT ZURICH","€1,999,865","To infect humans, the devastating pathogen Mycobacterium tuberculosis critically depends on two closely related siderophores – soluble carboxymycobactin and membrane-bound mycobactin – which capture iron with high affinity inside the host cell. Despite their undisputed importance for virulence, little is known about how these siderophores are exported and imported across the two mycobacterial membranes.Building on my lab’s experience in elucidating transport processes of pathogenic bacteria, we ",{"id":415,"funder":7,"programme":8,"title":416,"piName":14,"institution":417,"country":418,"year":13,"amount":419,"abstract":420},"cordis-european-research-council-award-771005","Symmetry in Computational Complexity","UNIVERZITA KARLOVA","CZ","€1,211,375","The last 20 years of rapid development in the computational-theoretic aspects of the fixed-language Constraint Satisfaction Problems (CSPs) has been fueled by a connection between the complexity and a certain concept capturing symmetry of computational problems in this class.My vision is that this connection will eventually evolve into the organizing principle of computational complexity and will lead to solutions of fundamental problems such as the Unique Games Conjecture or even the P-versus-N",{"id":422,"funder":7,"programme":8,"title":423,"piName":14,"institution":424,"country":93,"year":13,"amount":425,"abstract":426},"cordis-european-research-council-award-773209","Density assemblages: intensity and the city in a global urban age","UNIVERSITY OF DURHAM","€1,344,681","DenCity offers a new approach for understanding density and its relationship to the city. Density is a defining feature of the city and urban life. Across the world, density is now at the centre of policy and planning agendas to build cities that are environmentally, economically, socially and politically ‘sustainable’. While there is a lively tradition of research on density in the city, we lack an understanding of the different ways in which high densities are lived and perceived by residents.",{"id":428,"funder":7,"programme":8,"title":429,"piName":14,"institution":430,"country":431,"year":13,"amount":432,"abstract":433},"cordis-european-research-council-award-772032","The Nuclear Pore Basket – Functional Architecture of a Membrane Remodeling Machine","MEDIZINISCHE UNIVERSITAET WIEN","AT","€2,178,488","Nuclear pore complexes (NPCs) are gatekeepers at the nuclear envelope, mediating traffic between the nucleus and cytoplasm. Unlike simpler protein channels that insert into a single lipid bilayer, NPCs can remodel the outer and inner nuclear membranes to form a specialized pore in the nuclear envelope. High-resolution models of the symmetric NPC core have transformed our understanding of NPC architecture. In contrast, we know little about the NPC basket, a prominent structure on the nucleoplasmi",{"id":435,"funder":7,"programme":8,"title":436,"piName":14,"institution":437,"country":117,"year":13,"amount":438,"abstract":439},"cordis-european-research-council-award-770127","Polarity and Central-Symmetry in Asymptotic Geometric Analysis","TEL AVIV UNIVERSITY","€1,514,125","Asymptotic Geometric Analysis is a relatively new field, the young finite dimensional cousin of Banach Space theory, functional analysis and classical convexity. It concerns the {\\em geometric} study of high, but finite, dimensional objects, where the disorder of many parameters and many dimensions is ``regularized'' by convexity assumptions.   The proposed research is composed of several connected innovative studies in the frontier of Asymptotic Geometric Analysis, pertaining to the deeper unde",{"id":441,"funder":7,"programme":8,"title":442,"piName":14,"institution":443,"country":93,"year":13,"amount":14,"abstract":444},"cordis-european-research-council-award-772989","Exploring Cultural Memory in the Pre-Modern Islamic World (700–1500): Knowledge, Information Technology, and the Arabic Book","THE AGA KHAN UNIVERSITY (INTERNATIONAL) IN THE UNITED KINGDOM","KITAB (an acronym that also means “book” in Arabic) undertakes a highly innovative and transregional study of the Arabic book (700–1500) and its role in shaping cultural memory in the Islamic world. One of the most spectacularly prolific traditions in human history, the medieval Islamic world witnessed a literary outpouring surpassing the textual output of classical Antiquity and medieval Europe. Our knowledge of the Arabic book, however, is restricted and anecdotal along linguistic and historic",{"id":446,"funder":7,"programme":8,"title":447,"piName":14,"institution":448,"country":93,"year":13,"amount":449,"abstract":450},"cordis-european-research-council-award-772193","Colouring the Mind: the Impact of Visual Environment on Colour Perception","THE UNIVERSITY OF SUSSEX","€1,999,975","Visual perception is central to how we think and behave. However, there are major unresolved issues in understanding  how the human mind draws on experience to perceive the dynamic and variable world. The COLOURMIND project, led by Franklin, will tackle these crucial issues with an ambitious investigation of the impact of the visual environment on colour perception that will provide a new theoretical framework for the field. The project will ask ground-breaking questions: What aspects of colour ",{"id":452,"funder":7,"programme":8,"title":453,"piName":14,"institution":454,"country":21,"year":13,"amount":455,"abstract":456},"cordis-european-research-council-award-771528","The role of Softness in the Physics of  Defects: Probing Buried Interfaces in Perovskites Optoelectronic Devices","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","€2,150,000","SOPHY will develop the tools and knowledge to probe optoelectronic processes at buried interfaces, in devices, at operating conditions,  delivering a long time pursued target in many fields of nanotechnology. Semiconducting metal halide perovskites, and devices based on them, will be the primary technology under investigation, given its potential to represent the merging point between the efficient inorganic and the chameleonic organic electronics.  The presence of various types of chemical  int",{"id":458,"funder":7,"programme":8,"title":459,"piName":14,"institution":460,"country":12,"year":13,"amount":461,"abstract":462},"cordis-european-research-council-award-725194","Criminal Entanglements. A new ethnographic approach to transnational organised crime.","KOBENHAVNS UNIVERSITET","€1,999,909","Linked to terrorism, moral breakdown, and societal decay, Transnational Organised Crime (TOC) has come to embody current global anxieties as a figure of fear and cause of disquiet. Yet despite its central position on the social and political radar, our knowledge of it remains limited and fragmentary. Quantitative analyses may have identified the scale of the problem, but its underlying socio-cultural logic and practices remain under-researched and largely obscure. TOC is on the rise, and we need",{"id":464,"funder":7,"programme":8,"title":465,"piName":14,"institution":466,"country":141,"year":13,"amount":467,"abstract":468},"cordis-european-research-council-award-772797","Attosecond X-ray spectroscopy of liquids","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","€2,750,000","Charge and energy transfer are the key steps underlying most chemical reactions and biological transformations. The purely electronic dynamics that control such processes take place on attosecond time scales. A complete understanding of these dynamics on the electronic level therefore calls for new experimental methods with attosecond resolution that are applicable to aqueous environments. We propose to combine the element sensitivity of X-ray spectroscopy with attosecond temporal resolution and",{"id":470,"funder":7,"programme":8,"title":471,"piName":14,"institution":472,"country":141,"year":13,"amount":70,"abstract":473},"cordis-european-research-council-award-772751","Rapid mass loss of debris covered glaciers in High Mountain Asia","EIDGENOSSISCHE FORSCHUNGSANSTALT WSL","The research proposed uses an integrated data-modelling approach to elucidate the role that debris-covered glaciers play in the water cycle of High Mountain Asia (HMA) and establish how future HMA glacier and runoff will evolve. Debris-covered glaciers are of great significance for the hydrology of HMA, with large contributions to headwater streamflow. Despite this, their mass balance, hydrological role and future changes are poorly constrained, challenging model predictions of future water reso",{"id":475,"funder":7,"programme":8,"title":476,"piName":14,"institution":477,"country":21,"year":13,"amount":70,"abstract":478},"cordis-european-research-council-award-772168","Direct cell reprogramming therapy in myocardial regeneration through an engineered multifunctional platform integrating biochemical instructive cues","POLITECNICO DI TORINO","In BIORECAR I will develop a new breakthrough multifunctional biomaterial-based platform for myocardial regeneration after myocardial infarction, provided with biochemical cues able to enhance the direct reprogramming of human cardiac fibroblasts into functional cardiomyocytes.My expertise in bioartificial materials and biomimetic scaffolds and the versatile chemistry of polyurethanes will be the key elements to achieve a significant knowledge and technological advancement in cell reprogramming ",{"id":480,"funder":7,"programme":8,"title":481,"piName":14,"institution":482,"country":483,"year":13,"amount":484,"abstract":485},"cordis-european-research-council-award-770924","Inverse boundary problems: toward a unified theory","JYVASKYLAN YLIOPISTO","FI","€920,880","This proposal is concerned with the mathematical theory of inverse problems. This is a vibrant research field at the intersection of pure and applied mathematics, drawing techniques from PDE, geometry, and harmonic analysis as well as generating new research questions inspired by applications. Prominent questions include the Calderón problem related to electrical imaging, the Gel'fand problem related to seismic imaging, and geometric inverse problems such as inversion of the geodesic X-ray trans",{"id":487,"funder":7,"programme":8,"title":488,"piName":14,"institution":489,"country":69,"year":13,"amount":490,"abstract":491},"cordis-european-research-council-award-772505","Inheritance, expressivity and epistasis hidden behind the phenotypic landscape of natural populations","UNIVERSITE DE STRASBOURG","€1,999,882","Elucidating the causes of the awesome phenotypic diversity observed in natural populations is a major challenge in biology. It is now clear that the understanding of traits is not only hampered by non-heritable factors such as the environment and epigenetic variation, but also confounded by the lack of complete knowledge concerning the genetic components of traits. More than a century after the rediscovery of Mendel’s law, the genetic architecture of traits still resists generalization. First, t",{"id":493,"funder":7,"programme":8,"title":494,"piName":14,"institution":495,"country":93,"year":13,"amount":496,"abstract":497},"cordis-european-research-council-award-773067","The Insect cochlea: a non-invasive path towards enhanced sound detectors","UNIVERSITY OF LINCOLN","€1,989,789","There is a critical need for high-resolution acoustic sensors for numerous applications in engineering\u002Fmedicine.  The human cochlea has been a source of inspiration for acoustic sensors due its improved sensitivity, higher frequency range, and sharp frequency discrimination. Current methods for measuring cochlear mechanics are inherently invasive, and deep understanding of its process remains elusive, proving challenging its simulation in electromechanical devices. Yet cochlear organ for frequen",{"id":499,"funder":7,"programme":8,"title":500,"piName":14,"institution":501,"country":299,"year":13,"amount":14,"abstract":502},"cordis-european-research-council-award-772753","The Fall of 1200BC: The role of migration and conflict in social crises at end of the Bronze Age in South-eastern Europe","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","This project explores changes in migration and conflict at the end of the Bronze Age (ca.1300-1000 BC) and their relevance for understanding the collapse of Europe’s first urban civilisation in the Aegean and proto-urban groups of the Balkans. The objective is to uncover the human face of this turning point in European prehistory by directly tracing the movement of people and the spread of new social practices across cultural boundaries. Hotly debated ancient tales of migrations are tested for t",{"id":504,"funder":7,"programme":8,"title":505,"piName":14,"institution":506,"country":129,"year":13,"amount":507,"abstract":508},"cordis-european-research-council-award-772365","In vivo drug discovery for cellular reprogramming to β-cells  – towards a future regenerative therapy for diabetes","UPPSALA UNIVERSITET","€1,999,968","For almost a century we have been able to control diabetes with insulin injections, yet we still have no cure for this prevalent disease. One possible way to cure diabetes is by increasing the number of insulin-producing β-cells in the pancreas. Here, I propose to uncover factors and mechanisms that can increase β-cell numbers through cellular reprogramming. To do so, we will use two complementary discovery approaches—and transition between zebrafish, mouse and human analyses—to perform function",{"id":510,"funder":7,"programme":8,"title":511,"piName":14,"institution":512,"country":93,"year":13,"amount":513,"abstract":514},"cordis-european-research-council-award-771492","Deforestation – Climate –Atmospheric composition – Fire interactions and feedbacks","UNIVERSITY OF LEEDS","€1,965,623","Extensive and ongoing tropical deforestation and degradation have important environmental impacts. Smoke aerosol from deforestation fires degrades air quality, but the effects are poorly quantified. Deforestation alters rainfall through changes in the land surface and through changes to atmospheric aerosol. The magnitude and the sign of the rainfall response is not clear, because of poor process-level understanding and because previous attempts have studied land surface and aerosol responses sep",{"id":516,"funder":7,"programme":8,"title":517,"piName":14,"institution":518,"country":519,"year":13,"amount":520,"abstract":521},"cordis-european-research-council-award-772264","Negotiating post-imperial transitions: from remobilization to nation-state consolidation. A comparative study of local and regional transitions in post-Habsburg East and Central Europe","POLITIKATORTENETI INTEZET KOZHASZNU NON PROFIT KFT","HU","€1,963,075","The project’s goal is to provide a new, overall narrative of how the Habsburg Empire was replaced by nation states at the end of WWI and reconsider in the light of its results categories and concepts like state and statehood, local, regional and national, transition and transformation. A novel combination of historical comparison and histoire croisée enables the in-depth analyses of a set of local transitions in diverse regions (agrarian, industrial, commercial, urban, rural, multi-and mono-ethn",{"id":523,"funder":7,"programme":8,"title":524,"piName":14,"institution":525,"country":93,"year":13,"amount":70,"abstract":526},"cordis-european-research-council-award-772022","Spatiotemporal regulation of localization and replication of M. tuberculosis in human macrophages","THE FRANCIS CRICK INSTITUTE LIMITED","Mycobacterium tuberculosis (Mtb) is a very successful intracellular pathogen: in 2014, tuberculosis (TB) caused 1.5 million human deaths (World Health Organisation). To cause disease and disseminate to other hosts, Mtb needs to replicate within human cells. In spite of its enormous relevance for TB pathogenesis, the precise sites of Mtb replication in host cells remain unknown. This surprising gap in knowledge is in part due to the lack of appropriate imaging technologies that have precluded com",{"id":528,"funder":7,"programme":8,"title":529,"piName":14,"institution":381,"country":21,"year":13,"amount":530,"abstract":531},"cordis-european-research-council-award-771507","Stability Conditions, Moduli Spaces and Enhancements","€785,866","I will introduce new techniques to address two big open questions in the theory of derived\u002Ftriangulated categories and their many applications in algebraic geometry.The first one concerns the theory of Bridgeland stability conditions, which provides a notion of stability for complexes in the derived category. The problem of showing that the space parametrizing stability conditions is non-empty is one of the most difficult and challenging ones. Once we know that such stability conditions exist, i",{"id":533,"funder":7,"programme":8,"title":534,"piName":14,"institution":535,"country":69,"year":13,"amount":14,"abstract":536},"cordis-european-research-council-award-772539","Analysis and synthesis of wideband scattered signals from finite-size targets – aspect-independent RF analog footprint","INSTITUT POLYTECHNIQUE DE GRENOBLE","The need for information identification and capture is a matter of prime importance in modern societies. Every sectors of society rely on the identification of data exchanged, the updating of the data recorded on a tag and the measurement of physical parameters. The ability to make objects interact with one another or with humans is an important factor in many applications, all the more so if this interaction can occur without human presence. The way to reduce power consumption, improve the comm",{"id":538,"funder":7,"programme":8,"title":539,"piName":14,"institution":460,"country":12,"year":13,"amount":540,"abstract":541},"cordis-european-research-council-award-772735","Dissection of Glycan Function by Engineered Tissue Models","€1,995,199","Glycans decorate most proteins, cover cell membranes, and represent one of the four building blocks of life, together with nucleic acids, lipids, and amino acids. Yet, our understanding of how glycans influence the life of cells and organisms is limited, and only few functions have been molecularly dissected. Glycans present a huge structural diversity with species and cell- type specificity that underlie specific biological functions. However, more than half a century of research has been sever",{"id":543,"funder":7,"programme":8,"title":544,"piName":14,"institution":545,"country":117,"year":13,"amount":546,"abstract":547},"cordis-european-research-council-award-771112","Phenotype switching: plasticity and\u002For differentiation of stromal cells and their progenitors within the tumour microenvironment regulate tumour fate.","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","€1,906,250","The limited success of cancer therapy especially in advanced metastatic disease warrants a reassessment, especially given our limited understanding of the nature of cancer cells and the factors that allow them to proliferate and metastasise. Stromal cells of the tumour microenvironment, including fibroblasts, endothelial, immune, adipose and mesenchymal cells, significantly affect cancer cell characteristics and tumour fate; however, their sometimes dichotomous function in high- and low-aggressi",{"id":549,"funder":7,"programme":8,"title":550,"piName":14,"institution":176,"country":21,"year":13,"amount":551,"abstract":552},"cordis-european-research-council-award-772099","High precision multi-jet dynamics at the LHC","€1,764,478","Precision tests at high energy colliders are an essential tool for gaining insightinto the nature of the Standard Model of particle physics and the fundamental interactions. The data currently being obtained by the LHC experiments will allow a large number of observables to be measured at a percent level accuracy. This data has the potential to probe deeper into the flaws of the Standard Model. However, the complexity of theoretical predictions using perturbative quantum field theory currently p",{"id":554,"funder":7,"programme":8,"title":555,"piName":14,"institution":116,"country":117,"year":13,"amount":70,"abstract":556},"cordis-european-research-council-award-770964","A multi-scale perspective into collective problem solving in ants","Cognition improves an animal’s ability to tune its responses to environmental conditions. In group living animals, communication works to form a collective cognition that expands the group’s abilities beyond those of individuals. Despite much research, to date, there is little understanding of how collective cognition emerges within biological ensembles. A major obstacle towards such an understanding is the rarity of comprehensive multi-scale empirical data of these complex systems. We have demo",{"id":558,"funder":7,"programme":8,"title":559,"piName":14,"institution":560,"country":34,"year":13,"amount":561,"abstract":562},"cordis-european-research-council-award-773089","Metabolism of a cell pictured by single-cell approach","EUROPEAN MOLECULAR BIOLOGY LABORATORY","€2,330,628","Every cell is unique. Metabolites define the composition of each cell and play key roles in essential intracellular processes of energy production and uptake, signaling, regulation, and cell death. Obtaining metabolite signatures of individual cells and linking them to cellular phenotypes is of paramount importance for a holistic understanding of these processes. This requires high-throughput single-cell metabolomics that is not generally attainable due to the limited sensitivity, low throughput",{"id":564,"funder":7,"programme":8,"title":565,"piName":14,"institution":566,"country":123,"year":13,"amount":14,"abstract":567},"cordis-european-research-council-award-766555","Electrically Tunable Functional Lanthanide Nanoarchitectures on Surfaces","FUNDACION IMDEA NANOCIENCIA","Lanthanide metals are ubiquitous nowadays, finding use in luminescent materials, optical amplifiers and waveguides, lasers, photovoltaics, rechargeable batteries, catalysts, alloys, magnets, bio-probes, and therapeutic agents. In addition, they bear potential for high temperature superconductivity, magnetic refrigeration, molecular magnetic storage, spintronics and quantum information. Surprisingly, the study of lanthanide physico-chemical properties on surfaces is at its infancy, particularly a",{"id":569,"funder":7,"programme":8,"title":570,"piName":14,"institution":571,"country":256,"year":13,"amount":572,"abstract":573},"cordis-european-research-council-award-771057","The dynamics underlying Well-being; Understanding the Exposome-Genome interplay","STICHTING VU","€1,999,722","In light of major demographic trends, building and maintaining health and well-being amongst citizens is one of the most important societal challenges European countries face. People who feel well, function better, are less susceptible to mental illness, and thus are better able to retain competitive advantage and expand human capital. People who feel well also facilitate social capital by enjoying stronger and more-lasting relationships. Consequently, maintaining, facilitating, and building wel",{"id":575,"funder":7,"programme":8,"title":576,"piName":14,"institution":577,"country":69,"year":13,"amount":578,"abstract":579},"cordis-european-research-council-award-768679","Derived Symplectic Geometry and Applications","UNIVERSITE DE MONTPELLIER","€1,385,247","We propose a program that aims at providing new developments and new applications of shifted symplectic and Poisson structures. It is formulated in the language and framework of derived algebraic geometry after Toën–Vezzosi and Lurie. On the foundational side, we will introduce the new notion of shifted symplectic groupoids and prove that they provide an alternative approach to shifted Poisson structures (as they were defined by the PI together with Tony Pantev, Bertrand Toën, Michel Vaquié and ",{"id":581,"funder":7,"programme":8,"title":582,"piName":14,"institution":506,"country":129,"year":13,"amount":583,"abstract":584},"cordis-european-research-council-award-771777","FUNctionalized POLYmer electrolytes for energy STORagE","€1,950,732","Besides the need for large-scale implementation of renewable energy sources, there is an equivalent need for new energy storage solutions. This is not least true for the transport sector, where electric vehicles are expanding rapidly. The rich flora of battery chemistries – today crowned by the Li-ion battery – is likewise expected to expand in upcoming years. Novel types of batteries, “post-lithium ion”, will challenge the Li-ion chemistries by advantages in cost, sustainability, elemental abun",{"id":586,"funder":7,"programme":8,"title":587,"piName":14,"institution":571,"country":256,"year":13,"amount":588,"abstract":589},"cordis-european-research-council-award-771074","The Social Epistemology of Argumentation","€1,683,384","Argumentation -the practice of giving and asking for reasons to support claims - is a key component of scientific inquiry, legal procedures, and political life. But in many instances, argumentation does not achieve its presumed goal of fostering consensus and circulation of reliable information. Recent events in world politics - Brexit, US elections, refugee crisis - demonstrate that a better grasp of what argumentation can and cannot do for us is urgently needed.The key question of this project",{"id":591,"funder":7,"programme":8,"title":592,"piName":14,"institution":593,"country":34,"year":13,"amount":594,"abstract":595},"cordis-european-research-council-award-772108","Harvesting dark plasmons for surface-enhanced Raman scattering","FREIE UNIVERSITAET BERLIN","€2,299,506","Metal nanostructures show pronounced electromagnetic resonances that arise from localized surface plasmons. These collective oscillations of free electrons in the metal give rise to confined electromagnetic near fields. Surface-enhanced spectroscopy exploits the near-field intensity to enhance the optical response of nanomaterials by many orders of magnitude. Plasmons are classified as bright and dark depending on their interaction with far-field radiation. Bright modes are dipole-allowed excita",{"id":597,"funder":7,"programme":8,"title":598,"piName":14,"institution":599,"country":93,"year":13,"amount":600,"abstract":601},"cordis-european-research-council-award-772259","A topological approach to electron correlation in density-functional theories","THE UNIVERSITY OF NOTTINGHAM","€1,998,649","Density-functional theory (DFT) is the most widely used method to study the electronic structure of complex molecules, solids, and materials. Its use across chemistry, solid-state physics and materials science is a testament to its black-box nature and low cost. However, many important areas remain inaccessible to DFT simulations, including applications to strongly correlated materials and systems in electromagnetic fields. The topDFT project will deliver new conceptual approaches to design the ",{"id":603,"funder":7,"programme":8,"title":604,"piName":14,"institution":381,"country":21,"year":13,"amount":605,"abstract":606},"cordis-european-research-council-award-771642","Search for the electric dipole moment of strange and charm baryons at LHC","€1,933,750","SELDOM explores a new experimental method to decisively boost the study of the electric dipole moment (EDM) and magnetic dipole moment (MDM) of  baryons at the LHCb experiment at CERN. We will be able to guide the first search of charm baryons EDM: any observation would represent a signature of new physics. With the strange baryon EDM measurement, we will push forward the sensitivity on the Lambda baryon EDM to an unprecedented precision. Thus, we will set new constraints to extensions of the St",{"id":608,"funder":7,"programme":8,"title":609,"piName":14,"institution":610,"country":69,"year":13,"amount":611,"abstract":612},"cordis-european-research-council-award-771844","Towards a Reliable and Automated Analysis of Compromised Systems","EURECOM GIE","€1,991,504","The vast majority of research in computer security is dedicated to the design of detection, protection, and prevention solutions. While these techniques play a critical role to increase the security and privacy of our digital infrastructure, it is enough to look at the news to understand that it is not a matter of if a computer system will be compromised, but only a matter of when. It is a well known fact that there is no 100% secure system, and that there is no practical way to prevent attacker",{"id":614,"funder":7,"programme":8,"title":615,"piName":14,"institution":616,"country":34,"year":13,"amount":617,"abstract":618},"cordis-european-research-council-award-771432","Decision making: from neurochemical mechanisms to network dynamics to behaviour","HEINRICH-HEINE-UNIVERSITAET DUESSELDORF","€1,903,698","How we decide between different alternatives is a central question to cognitive neuroscience. Decisions may appear trivial (selecting between two meals), or sophisticated and long reaching (deciding whom to marry). Decisions constitute a highly dynamical process of evidence accumulation. These dynamics can be represented in cortical oscillations, which have attracted great interest as a key mechanism that coordinates fast computations. While a few studies have investigated the role of cortical o",{"id":620,"funder":7,"programme":8,"title":621,"piName":14,"institution":110,"country":111,"year":13,"amount":622,"abstract":623},"cordis-european-research-council-award-773208","Harnessing tumor metabolism to overcome immunosupression","€1,999,721","Anti-cancer immunotherapy has provided patients with a promising treatment. Yet, it has also unveiled that the immunosuppressive tumor microenvironment (TME) hampers the efficiency of this therapeutic option and limits its success. The concept that metabolism is able to shape the immune response has gained general acceptance. Nonetheless, little is known on how the metabolic crosstalk between different tumor compartments contributes to the harsh TME and ultimately impairs T cell fitness within t",{"id":625,"funder":7,"programme":8,"title":626,"piName":14,"institution":627,"country":165,"year":13,"amount":628,"abstract":629},"cordis-european-research-council-award-772039","Discovery and functional significance of post-translational N-terminal acetylation","UNIVERSITETET I BERGEN","€1,999,273","In mammalian cells, N-terminal (Nt) acetylation is one of the most abundant protein modifications. It is catalysed by N-terminal acetyltransferases (NATs) and mostly occurs co-translationally. However, in contrast to the defined co-translational NATs, post-translational NATs which have crucial regulatory roles are mostly unexplored. Distinct peptide hormones regulate appetite, metabolism, sexual behaviour and pain, and their biological activity is critically modulated by post-translational Nt-ac",{"id":631,"funder":7,"programme":8,"title":632,"piName":14,"institution":482,"country":483,"year":13,"amount":633,"abstract":634},"cordis-european-research-council-award-770884","Complex eco-evolutionary dynamics of aquatic ecosystems faced with human-induced and environmental stress","€1,999,391","Resilience and recovery ability are key determinants of species persistence and viability in a changing world. Populations exposed to rapid environmental changes and human-induced alterations are often affected by both ecological and evolutionary processes and their interactions, that is, eco-evolutionary dynamics. The integrated perspective offered by eco-evolutionary dynamics is vital for understanding drivers of resilience and recovery of natural populations undergoing rapid changes and expos",{"id":636,"funder":7,"programme":8,"title":637,"piName":14,"institution":638,"country":34,"year":13,"amount":639,"abstract":640},"cordis-european-research-council-award-772957","From herds to empire: Biomolecular and zooarchaeological investigations of mobile pastoralism in the ancient Eurasian steppe","CHRISTIAN-ALBRECHTS-UNIVERSITAET  ZU KIEL","€1,999,145","The emergence of mobile pastoralism in the Eurasian steppe five thousand years ago marked a unique transformation in human lifeways where, for the first time, people relied almost exclusively on herd animals of sheep, goat, cattle, and horses for sustenance and as symbols. Mobile pastoralism also generated altogether new forms of socio-political organization exceptional to the steppe that ultimately laid the foundation for nomadic states and empires. However, there remain striking gaps in our kn",{"id":642,"funder":7,"programme":8,"title":643,"piName":14,"institution":644,"country":93,"year":13,"amount":645,"abstract":646},"cordis-european-research-council-award-772854","The Political Economy of African Development. Ethnicity, Nation, and History","LONDON BUSINESS SCHOOL","€1,555,679","This proposal aims to measure, document, and understand the historical origins of contemporary African inequality that has a strong ethnic component. The focus is on the interplay of the nation and the ethnicity that co-evolve, sometimes violently and sometimes peacefully across the continent. The proposal consists of four closely related projects.   The first project develops a large database portraying the evolution of inequality and intergenerational mobility in education covering the full po",{"id":648,"funder":7,"programme":8,"title":649,"piName":14,"institution":650,"country":256,"year":13,"amount":70,"abstract":651},"cordis-european-research-council-award-770402","Forensic Culture. A Comparative Analysis of Forensic Practices in Europe, 1930-2000","UNIVERSITEIT UTRECHT","In television series like CSI and Criminal Minds forensic scientists can solve even the trickiest cases within a few hours. Technologies such as blood-spatter analysis, DNA and autopsies aid in reconstructing the crime and psychiatric classifications like ‘psychopath’ help to identify the perpetrator. Science and technology’s impartial and unambiguous results seem to ensure that justice is done equally for everyone. In reality, however, the role and impact of forensic science depend on where the",{"id":653,"funder":7,"programme":8,"title":654,"piName":14,"institution":655,"country":129,"year":13,"amount":14,"abstract":656},"cordis-european-research-council-award-724557","Creating an Alternative umma: Clerical Authority and Religio-political Mobilisation in Transnational Shii Islam","LUNDS UNIVERSITET","This interdisciplinary project investigates the transformation of Shii Islam in the Middle East and Europe since the 1950s. The project examines the formation of modern Shii communal identities and the role Shii clerical authorities and their transnational networks have played in their religio-political mobilisation. The volatile situation post-Arab Spring, the rise of militant movements such as ISIS and the sectarianisation of geopolitical conflicts in the Middle East have intensified efforts t",{"id":658,"funder":7,"programme":8,"title":659,"piName":14,"institution":128,"country":129,"year":13,"amount":660,"abstract":661},"cordis-european-research-council-award-771770","Revealing Sources of Gendered Parenthood: A multi-method comparative study of the transition to parenthood in same-sex and different-sex couples","€1,999,910","This project is the first to apply an inclusive, internationally comparative, multi-methods approach to families to reveal the complex processes that result in a gendered division of work. We do this by comparing different-sex couples (DSC) to same-sex couples (SSC) focusing on the transition to parenthood and its career related consequences based on unique, population register data, census data and surveys, as well in depth interviews with couples. Three sub-projects emerge. In GENPARENT NORTH,",{"id":663,"funder":7,"programme":8,"title":664,"piName":14,"institution":665,"country":93,"year":13,"amount":666,"abstract":667},"cordis-european-research-council-award-771635","Solidarity in the European Union","KING'S COLLEGE LONDON","€1,013,604","What principles of socioeconomic justice, if any, should apply to the European Union? Do European citizens have obligations of social justice that cross the borders of member states? If so, what are their grounds? I propose to answer these questions by providing a normative account of one of the fundamental values underpinning European integration, namely solidarity. The project has two main aims. The first is to develop a normative model of inter-, trans-, and supra-national solidarity that is ",{"id":669,"funder":7,"programme":8,"title":670,"piName":14,"institution":671,"country":34,"year":13,"amount":672,"abstract":673},"cordis-european-research-council-award-772479","New transversality techniques in holomorphic curve theories","HUMBOLDT-UNIVERSITAET ZU BERLIN","€1,624,500","In the study of symplectic and contact manifolds, a decisive role has been played by the theory of pseudoholomorphic curves, introduced by Gromov in 1985.  One major drawback of this theory is the fundamental conflict between genericity and symmetry, which for instance causes moduli spaces of holomorphic curves to be singular or have the wrong dimension whenever multiply covered curves are present.  Most traditional solutions to this problem involve abstract perturbations of the Cauchy-Riemann e",{"id":675,"funder":7,"programme":8,"title":676,"piName":14,"institution":677,"country":12,"year":13,"amount":14,"abstract":678},"cordis-european-research-council-award-773122","Controlling light-matter interactions by quantum designed 2D materials","DANMARKS TEKNISKE UNIVERSITET","Progress within many contemporary or emergent technologies, including photovoltaics, single-photon light sources, and plasmonics, depends crucially on our ability to control the interactions between light and matter. The complexity of the light-matter interactions has made the development of photonic materials a slow, expensive, and empirical-based science. Of particular importance are the detrimental non-radiative processes mediated by defects and phonons that lead to efficiency losses in photo",{"id":680,"funder":7,"programme":8,"title":681,"piName":14,"institution":677,"country":12,"year":13,"amount":682,"abstract":683},"cordis-european-research-council-award-772370","Pyrolytic Hierarchical Organic Electrodes for sustaiNable Electrochemical Energy Systems","€2,745,500","The demand for compact energy systems for portable devices such as wearable sensors or mobile phones is increasing. Electrochemical systems are promising candidates for sustainable energy conversion and storage on miniaturised platforms. A recent approach to harvest green energy is biophotovoltaic systems (BPVs), where photosynthetic microorganisms are used to transform light into electrical energy. However, BPVs still provide a relatively low efficiency and are yet unable to deliver the high pe",{"id":685,"funder":7,"programme":8,"title":686,"piName":14,"institution":571,"country":256,"year":13,"amount":687,"abstract":688},"cordis-european-research-council-award-771391","The unknown force: How gossip shapes the functioning and performance of organizational groups.","€1,999,693","Aim: To radically change the field of gossip research, this project builds theory that connects divergent perspectives on the effects of gossip on work group outcomes.Background: Gossip, informal evaluative talk about absent third parties, is omnipresent in organizational groups. However, for scientists and practitioners alike, it is still an unknown force in organizations, because research findings about its effects on group functioning and performance are inconsistent. Whereas some studies poi",{"id":690,"funder":7,"programme":8,"title":691,"piName":14,"institution":460,"country":12,"year":13,"amount":692,"abstract":693},"cordis-european-research-council-award-726114","How do infants mentalize? Bringing a neuroimaging approach to the puzzle of early mindreading.","€1,761,190","Human social interaction and learning depends on making the right inferences about other people’s thoughts, a process commonly called mentalizing, or Theory of Mind, a cognitive achievement which several decades of research concluded was reached at around age 4. The last 10 years has radically changed this view, and innovative new paradigms suggest that even preverbal infants can think about others’ minds. This new developmental data has created arguably one of the biggest puzzles in the history",{"id":695,"funder":7,"programme":8,"title":696,"piName":14,"institution":697,"country":69,"year":13,"amount":698,"abstract":699},"cordis-european-research-council-award-771813","Investigating the functional architecture of microbial genomes with synthetic approaches","INSTITUT PASTEUR","€1,995,557","The folding of eukaryotic and prokaryotic chromosomes consists of an assortment of intertwined structural features. The resulting complex networks of contacts is highly dynamic and interacts functionally with, or regulates metabolic processes ranging from gene expression to chromosome segregation. Some higher order structures involve evolutionary conserved molecular players, such as structural maintenance of chromosomes (SMC) proteins, while others depend on phylum specific proteins. The functio",{"id":701,"funder":7,"programme":8,"title":702,"piName":14,"institution":703,"country":431,"year":13,"amount":704,"abstract":705},"cordis-european-research-council-award-771193","Single-Atom Radio Frequency Fingerprinting","UNIVERSITAT LINZ","€1,998,000","Precise investigation tools for analyzing and manipulating matter down to the scale of single atoms are the eyes, ears and fingers of nanoscience and -engineering. SARF takes these nano-analytical senses one next step beyond the present state of the art. SARF is breaking new grounds by enabling spectral fingerprinting of single atoms for elemental identification and intra-molecular chemical analytics with sub-nanometer spatial resolution and operating in vacuum- as well as liquid-phase environme",{"id":707,"funder":7,"programme":8,"title":708,"piName":14,"institution":709,"country":93,"year":13,"amount":710,"abstract":711},"cordis-european-research-council-award-725920","Two-dimensional quantum photonics","HERIOT-WATT UNIVERSITY","€1,999,135","Quantum optics, the study of how discrete packets of light (photons) and matter interact, has led to the development of remarkable new technologies which exploit the bizarre properties of quantum mechanics. These quantum technologies are primed to revolutionize the fields of communication, information processing, and metrology in the coming years. Similar to contemporary technologies, the future quantum machinery will likely consist of a semiconductor platform to create and process the quantum i",{"id":713,"funder":7,"programme":8,"title":714,"piName":14,"institution":715,"country":93,"year":13,"amount":716,"abstract":717},"cordis-european-research-council-award-772228","Controlling and resolving rotational quantum states in a molecule-surface collision: Matter-wave magnetic interference experiments with ground state molecules.","SWANSEA UNIVERSITY","€2,230,400","The interaction between a molecule and a solid surface is fundamental to a huge variety of research fields and applications, ranging from industrial heterogeneous catalysis and atmospheric chemistry on ice particles, to ultra-cold astrochemical reactions on cosmic dust. One molecular property that is essential for molecule surface interactions, but also particularly difficult to control and resolve, is the orientation & alignment of the rotational axis of the molecule i.e. the quantum rotation p",{"id":719,"funder":7,"programme":8,"title":720,"piName":14,"institution":721,"country":69,"year":13,"amount":722,"abstract":723},"cordis-european-research-council-award-771691","Composition of solar system small bodies","UNIVERSITE GRENOBLE ALPES","€2,421,180","The small bodies population (comets, asteroids, KBOs) is today central to Solar System studies. These objects are used to reconstruct the dynamical scenarios of Solar System formation and evolution, and are expected to have played a key role in the habitability of terrestrial planets. Because they are rich in volatile and organics, comets and dark asteroid types (C-, D-) are under intense scrutiny by the Planetary Science community. The objective of this project is to determine the composition o",{"id":725,"funder":7,"programme":8,"title":726,"piName":14,"institution":727,"country":111,"year":13,"amount":728,"abstract":729},"cordis-european-research-council-award-772225","The MULTIPLicity of supErnova progenitorS","KATHOLIEKE UNIVERSITEIT LEUVEN","€1,991,243","With stellar masses in the range of eight to several hundreds of solar masses, massive stars are among the most important cosmic engines, each individual object strongly impacting its local environment and populations of massive stars driving the evolution of galaxies throughout the history of the universe. Recently, I have shown that stars more massive than 15 Msun rarely, if at all, form and live in isolation but rather as part of a binary or higher-order multiple system. Understanding the lif",{"id":731,"funder":7,"programme":8,"title":732,"piName":14,"institution":733,"country":734,"year":13,"amount":735,"abstract":736},"cordis-european-research-council-award-773012","Whole-brain circuits controlling visuomotor behavior","FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD","PT","€1,694,063","Understanding how our brains extract relevant features of sensory input to select and guide appropriate actions is a fundamental goal of neuroscience. Yet even relatively simple sensorimotor reflexes can depend on activity within complex networks of neurons that are distributed across the brain, presenting a challenge for traditional neuroscience approaches. Our recent work has demonstrated the capacity to image neural activity with single cell resolution throughout the small transparent brain o",{"id":738,"funder":7,"programme":8,"title":739,"piName":14,"institution":466,"country":141,"year":13,"amount":740,"abstract":741},"cordis-european-research-council-award-770880","Computation and analysis of statistical solutions of fluid flow","€1,959,323","Entropy (admissible) weak solutions are widely considered to be the standard solution framework for hyperbolic systems of conservation laws and incompressible Euler equations. However, the lack of global existence results in several space dimensions, the recent demonstration of non-uniqueness of these solutions and computations showing the lack of convergence of state of the art numerical methods to them, have reinforced the need to seek alternative solution paradigms. Although one can show that",{"id":743,"funder":7,"programme":8,"title":744,"piName":14,"institution":745,"country":34,"year":13,"amount":14,"abstract":746},"cordis-european-research-council-award-772049","Nuclear mRNA Packaging and mRNP Architecture","JUSTUS-LIEBIG-UNIVERSITAET GIESSEN","An important step of gene expression is the formation of a messenger ribonucleoprotein particle (mRNP). The messenger RNA (mRNA) is synthesized by RNA polymerase II transcribing a protein-coding gene. The mRNA is processed, i.e. capped, spliced and polyadenylated, and packaged into an mRNP by binding of RNA-binding proteins (RBPs). The RBPs bound to the mRNA are essential for the stability of the mRNP, control nuclear mRNA export and often determine cytoplasmic processes such as mRNA localizatio",{"id":748,"funder":7,"programme":8,"title":749,"piName":14,"institution":750,"country":111,"year":13,"amount":751,"abstract":752},"cordis-european-research-council-award-771704","Novel Metabolic Pathways in Cancer","UNIVERSITE CATHOLIQUE DE LOUVAIN","€1,989,103","Metabolic adaptations in central carbon metabolism play a key role in cancer. Yet, the success of therapeutic interventions in major pathways has been limited, although some of the changes have been known to exist for almost 100 years. Biochemical textbooks present intermediary metabolism as something canonical, and the molecular identity of most enzymes required for the production of known intermediary metabolites is indeed known. Yet, the function of many putative enzymes is still unknown, ind",{"id":754,"funder":7,"programme":8,"title":755,"piName":14,"institution":756,"country":129,"year":13,"amount":757,"abstract":758},"cordis-european-research-council-award-772874","The Genomics of Feralisation","LINKOPINGS UNIVERSITET","€1,989,590","Feralisation is a complex process that occurs when a domestic population is returned to the wild. It impacts species invasion biology, speciation, conservation and hybridisation and can be thought of as the reverse of domestication. Domestication has been an area of intense interest and study ever since Darwin, and useful as a model for evolution and the effects of strong directional selection. This project will identify underlying genes and mechanisms of trade-offs and adaptations surrounding f",{"id":760,"funder":7,"programme":8,"title":761,"piName":14,"institution":762,"country":93,"year":13,"amount":763,"abstract":764},"cordis-european-research-council-award-770816","Commentary Manuscripts in the History and Transmission of the Greek New Testament","THE UNIVERSITY OF BIRMINGHAM","€1,756,928","Manuscripts which contain commentary alongside the biblical text are some of the most significant and complicated witnesses to the Greek New Testament. First compiled around the fifth century, the commentaries consist of chains of extracts from earlier writers (catenae). These manuscripts became the main way in which users encountered both the text and the interpretation of the New Testament; revised editions produced in the eleventh and twelfth centuries continued to hold the field until the in",{"id":766,"funder":7,"programme":8,"title":767,"piName":14,"institution":768,"country":34,"year":13,"amount":769,"abstract":770},"cordis-european-research-council-award-771143","Melting And Geodynamic Models of Ascent","JOHANNES GUTENBERG-UNIVERSITAT MAINZ","€1,994,250","The production and migration of magma through the lithosphere results in spectacular geological processes such as volcanic eruptions, giant ore deposits, large magmatic intrusions, and is responsible for the formation of continents on Earth.Since magmatic systems develop on timescales of millions of years and are not directly accessible, we have to reconstruct them indirectly, such as by studying exhumed magmatic intrusions, or by using geophysical methods. Interpreting these data is complicated",{"id":772,"funder":7,"programme":8,"title":773,"piName":14,"institution":627,"country":165,"year":13,"amount":774,"abstract":775},"cordis-european-research-council-award-773245","Isotopic links to atmopheric water's sources","€1,999,054","The hydrological cycle, with its feedbacks related to water vapour and clouds, is the largest source of uncertainty in weather prediction and climate models. Particularly processes that occur on scales smaller than the model grid lead to errors, which can compensate one another, making them difficult to detect and correct for. Undetectable compensating errors critically limit the understanding of hydrological extremes, the response of the water cycle to a changing climate, and the interpretation",{"id":777,"funder":7,"programme":8,"title":778,"piName":14,"institution":779,"country":123,"year":13,"amount":780,"abstract":781},"cordis-european-research-council-award-772762","Ioculator seu mimus. Performing Music and Poetry in medieval Iberia","UNIVERSITAT DE BARCELONA","€1,341,869","What was the role played by courtly musicians and poets in fostering a performative dimension of cultural life in the late Middle Ages? How did this contribute to the social value of the poet and musician as an artist? In the late medieval period the Crown of Aragon was a political and cultural crossroads, a coveted destination for artists of various kinds who attended the refined court of the Catalan kings. Musicians and performing entertainers with skills in the verbal and non-verbal domains w",{"id":783,"funder":7,"programme":8,"title":784,"piName":14,"institution":785,"country":141,"year":13,"amount":786,"abstract":787},"cordis-european-research-council-award-771534","The role of cell-to-cell variability in pneumococcal virulence and antibiotic resistance","UNIVERSITE DE LAUSANNE","€1,999,735","Within clonal bacterial populations not all cells exhibit the same phenotype, even though they grow in the same environment. The molecular sources contributing to phenotypic variation are diverse and can originate from noise in gene expression to heterogeneity in growth rates or cell cycle state. Phenotypic variation helps pathogenic bacteria to elude the host immune response or resist antibiotic pressure. Vice versa, there is cell-to-cell variability in the host’s response towards pathogens tha",{"id":789,"funder":7,"programme":8,"title":790,"piName":14,"institution":791,"country":34,"year":13,"amount":792,"abstract":793},"cordis-european-research-council-award-772395","Hypothalamic mechanisms of thermal homeostasis and adaptation","UNIVERSITATSKLINIKUM HEIDELBERG","€1,902,500","Mammalian organisms possess the remarkable ability to maintain internal body temperature (Tcore) within a narrow range close to 37°C despite wide environmental temperature variations. The brain’s neural “thermostat” is made up by central circuits in the hypothalamic preoptic area (POA), which orchestrate peripheral thermoregulatory responses to maintain Tcore. Thermogenesis requires metabolic fuel, suggesting intricate connections between the thermoregulatory centre and hypothalamic circuits con",{"id":795,"funder":7,"programme":8,"title":796,"piName":14,"institution":797,"country":519,"year":13,"amount":798,"abstract":799},"cordis-european-research-council-award-771849","Dendrites and memory: role of dendritic spikes in information coding by hippocampal CA3 pyramidal neurons","HUN-REN KISERLETI ORVOSTUDOMANYI  KUTATOINTEZET","€1,990,314","The hippocampus is essential for building episodic memories. Coding of locations, contexts or events in the hippocampus is based on the correlated activity of neuronal ensembles; however, the mechanisms promoting the recruitment of individual neurons into information-coding ensembles are poorly understood.In particular, the recurrent synaptic network of pyramidal cells (PCs) in the hippocampal CA3 area, receiving external inputs from the entorhinal cortex and the dentate gyrus, is thought to be ",{"id":801,"funder":7,"programme":8,"title":802,"piName":14,"institution":803,"country":256,"year":13,"amount":804,"abstract":805},"cordis-european-research-council-award-772923","Plastic in the Ocean: Microbial Transformation of  an ‘Unconventional’ Carbon Substrate","STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN","€1,999,185","Large quantities of plastics comprising a diverse set of hydrocarbon or hydrocarbon-like polymers are constantly released to the oceans. The impacts of plastics in marine environments are detrimental, as they are seemingly recalcitrant and harmful to marine life. The severity of this problem is gaining momentum because the untamed demand for plastics has led to an ever-increasing release of plastic to the sea. However, despite their seemingly persistent properties, they do not accumulate as expe",{"id":807,"funder":7,"programme":8,"title":808,"piName":14,"institution":809,"country":34,"year":13,"amount":810,"abstract":811},"cordis-european-research-council-award-771234","Human health and migration in prehistory","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€1,997,500","Recent ancient DNA studies have discovered a basal form of Yersinia pestis, the causative agent of bubonic plague, in 5,000 year-old individuals from Eastern and Central Europe. Even though this strain is an early form that does likely not survive in fleas and might have been less transmissible, the timing intriguingly coincides with a period of substantial societal changes. The archaeological record of 3rd millennium BC Europe clearly demonstrates the demise of terminal Stone Age and the rise o",{"id":813,"funder":7,"programme":8,"title":814,"piName":14,"institution":815,"country":483,"year":13,"amount":816,"abstract":817},"cordis-european-research-council-award-773076","Development of antagonists of vascular leakage","HELSINGIN YLIOPISTO","€1,999,770","Dysregulation of capillary permeability is a severe problem in critically ill patients, but the mechanisms involved are poorly understood. Further, there are no targeted therapies to stabilize leaky vessels in various common, potentially fatal diseases, such as systemic inflammation and sepsis, which affect millions of people annually. Although a multitude of signals that stimulate opening of endothelial cell-cell junctions leading to permeability have been characterized using cellular and in vi",{"id":819,"funder":7,"programme":8,"title":820,"piName":14,"institution":821,"country":93,"year":13,"amount":822,"abstract":823},"cordis-european-research-council-award-771387","Sociocomplexity — new paradigms for understanding complex group-level adaptation","THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS","€1,968,688","Natural selection explains the appearance of design in the living world. But at what level is adaptive design expected to manifest (gene, organism or society) and what is its function? Adaptation may manifest at multiple levels, and indeed new levels of adaptive individuality may evolve over time – such as with the emergence of multicellularity and eusociality. However, understanding the forces that drive such “major transitions” remains a challenge: current theory, with its focus on single, sim",{"id":825,"funder":7,"programme":8,"title":826,"piName":14,"institution":460,"country":12,"year":13,"amount":827,"abstract":828},"cordis-european-research-council-award-772960","Loops and groups: Geodesics, moduli spaces, and infinite discrete groups via string topology and homological stability","€1,864,419","This proposal lies at the intersection of algebra, topology, and geometry, with the scientific goal of answering central questions about homological stability, geodesics on manifolds, and the moduli space of Riemann surfaces. Homological stability is a subject that has seen spectacular progress in recent years, and recent work of the PI has opened up new perspectives on this field, through, among other things, associating a canonical family of spaces to any stability problem. The first two goals",{"id":830,"funder":7,"programme":8,"title":831,"piName":14,"institution":832,"country":93,"year":13,"amount":833,"abstract":834},"cordis-european-research-council-award-769080","mRNA cap regulation and function in CD8 T cells","BEATSON INSTITUTE FOR CANCER RESEARCH LBG","€1,991,387","CD8 T cells are vital for our response to infection, directly killing infected cells and stimulating other cells of the immune system.  Major health problems world-wide involve deregulated T cells, including lymphomas, leukaemias, auto-immune disorders and organ transplant rejection.  Damaging deficiencies of T cells are found in old-age.  T cell development and response to pathogens is driven by regulated transcription and translation, however the mechanisms orchestrating this gene regulation a",{"id":836,"funder":7,"programme":8,"title":837,"piName":14,"institution":838,"country":839,"year":13,"amount":840,"abstract":841},"cordis-european-research-council-award-771567","An investigation of the mechanisms at the interaction between cavitation bubbles and contaminants","UNIVERZA V LJUBLJANI","SI","€1,904,565","A sudden decrease in pressure triggers the formation of vapour and gas bubbles inside a liquid medium (also called cavitation). This leads to many (key) engineering problems: material loss, noise and vibration of hydraulic machinery. On the other hand, cavitation is a potentially a useful phenomenon: the extreme conditions are increasingly used for a wide variety of applications such as surface cleaning, enhanced chemistry, and waste water treatment (bacteria eradication and virus inactivation).",{"id":843,"funder":7,"programme":8,"title":844,"piName":14,"institution":845,"country":93,"year":13,"amount":846,"abstract":847},"cordis-european-research-council-award-771863","Graded constraints in semantic cognition: How do we retrieve knowledge in a flexible way?","UNIVERSITY OF YORK","€1,999,860","For any concept, we have knowledge about diverse features – for example, a dog is furry, can chase rabbits, and is “man’s best friend”. How, at a specific moment, do we flexibly retrieve relevant conceptual knowledge that suits our current goals and context? We can promote coherence between weakly-related aspects of knowledge as required, and also achieve the timely release from patterns of retrieval when the situation changes. These effects are likely to play a central role in our mental lives ",{"id":849,"funder":7,"programme":8,"title":850,"piName":14,"institution":851,"country":34,"year":13,"amount":70,"abstract":852},"cordis-european-research-council-award-773161","Deep Learning for Dynamic 3D Visual Scene Understanding","RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN","Over the past 5 years, deep learning has exercised a tremendous and transformational effect on the field of computer vision. However, deep neural networks (DNNs) can only realize their full potential when applied in an end-to-end manner, i.e., when every stage of the processing pipeline is differentiable with respect to the network’s parameters, such that all of those parameters can be optimized together. Such end-to-end learning solutions are still rare for computer vision problems, in particul",{"id":854,"funder":7,"programme":8,"title":855,"piName":14,"institution":856,"country":111,"year":13,"amount":857,"abstract":858},"cordis-european-research-council-award-769595","Control of impulsive action","UNIVERSITEIT GENT","€1,998,438","Adaptive behaviour is typically attributed to an executive-control system that allows people to regulate impulsive actions and to fulfil long-term goals instead. Failures to regulate impulsive actions have been associated with a variety of clinical and behavioural disorders. Therefore, establishing a good understanding of impulse-control mechanisms and how to improve them could be hugely beneficial for both individuals and society at large. Yet many fundamental questions remain unanswered. This ",{"id":860,"funder":7,"programme":8,"title":861,"piName":14,"institution":862,"country":256,"year":13,"amount":70,"abstract":863},"cordis-european-research-council-award-773079","Communication in Action:  Towards a model of Contextualized Action and Language Processing","STICHTING RADBOUD UNIVERSITEIT","Language is fundamental to human sociality. While the last century has given us many fundamental insights into how we use and understand it, core issues that we face when doing so within its natural environment—face-to-face conversation—remain untackled. When we speak we also send signals with our head, eyes, face, hands, torso, etc. How do we orchestrate and integrate all this information into meaningful messages? CoAct will lead to a new model with in situ language processing at its core, the ",{"id":865,"funder":7,"programme":8,"title":866,"piName":14,"institution":116,"country":117,"year":13,"amount":867,"abstract":868},"cordis-european-research-council-award-770869","Deciphering molecular pathways of circadian clock communication","€1,999,945","The overarching objective of this interdisciplinary project is to elucidate mechanisms through which billions of individual clocks in the body communicate with each other and tick in harmony. The mammalian circadian timing system consists of a master clock in the brain and subsidiary oscillators in almost every cell of the body. Since these clocks anticipate environmental changes and function together to orchestrate daily physiology and behavior their temporal synchronization is critical. Our re",{"id":870,"funder":7,"programme":8,"title":871,"piName":14,"institution":872,"country":431,"year":13,"amount":873,"abstract":874},"cordis-european-research-council-award-771402","EPIDEMICS in ant societies ON a CHIP","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","€1,991,564","Living in societies amplifies the risk of getting sick, as pathogens can easily spread along the dense social interaction networks of the hosts. Sanitary care and the organisational structure of societies are expected to limit the risk of epidemics. Yet, how the defences of the individual group members scale-up, combine and synergise towards society-level protection, is poorly understood, as the majority of societies can only be studied via correlational and modeling approaches. Insect societies",{"id":876,"funder":7,"programme":8,"title":877,"piName":14,"institution":650,"country":256,"year":13,"amount":878,"abstract":879},"cordis-european-research-council-award-771288","Race to the bottom? Family labour, household livelihood and consumption in the relocation of global cotton manufacturing, ca. 1750-1990","€1,999,250","Globalization and the shift of industries and jobs to low-wage countries are topical political issues, but have deep historical roots. For long, cotton manufacturing has been central in global trade and industrial relocation. Textile production has existed almost everywhere, but its major export centres have relocated in the past 250 years, notably from Asia to Europe\u002Fthe US, then back to Asia. When and why these shifts occur is however still poorly understood. Reducing labour costs has been arg",{"id":881,"funder":7,"programme":8,"title":882,"piName":14,"institution":883,"country":93,"year":13,"amount":884,"abstract":885},"cordis-european-research-council-award-771443","Dynamic Activatable Fluorophores","THE UNIVERSITY OF EDINBURGH","€1,986,650","In DYNAFLUORS I will develop the first chemical toolbox for imaging in real time the activity of immune cells in tumours.Although the management of cancer has improved over the years, the cure rates for patients with metastasis and advanced tumours remain low due to lack of appropriate therapies. Recent studies suggest that drugs empowering host immune cells (i.e. immunotherapies) are promising approaches for intractable tumours. However, there are no tools to visualise and understand how host i",{"id":887,"funder":7,"programme":8,"title":888,"piName":14,"institution":140,"country":141,"year":13,"amount":889,"abstract":890},"cordis-european-research-council-award-771383","Global Horizons in Pre-Modern Art","€1,904,188","The horizon is the line that seems to separate earth from sky, the line that divides all visible categories into two categories: those that intersect the earth’s surface and those that do not. The horizon is key to the experience of space; it defines our perspective on the visible world. The GLOBAL HORIZONS project will investigate the historical meanings and functions of the horizon in visual and intellectual cultures of the pre-Modern world on a global scale. Examining how pre-Modern cultures ",{"id":892,"funder":7,"programme":8,"title":893,"piName":14,"institution":894,"country":21,"year":13,"amount":895,"abstract":896},"cordis-european-research-council-award-771536","New states of Entangled Matter Out of equilibrium","SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE","€1,521,423","When an extended quantum system is suddenly brought out of thermodynamic equilibrium all excitations collectively participate in the ensuing quench dynamics, causing a plethora of unconventional and exotic effects, in particular in low spatial dimensions where the effects of interactions and integrability are enhanced. The theoretical study of the non-equilibrium dynamics is hampered by the fact that the time dependent many-body wave function is highly entangled on spatial scales which rapidly g",{"id":898,"funder":7,"programme":8,"title":899,"piName":14,"institution":900,"country":93,"year":13,"amount":901,"abstract":902},"cordis-european-research-council-award-772577","The Tumour Stroma as a Driver of Clonal Selection","THE UNIVERSITY OF MANCHESTER","€1,969,768","Pancreatic ductal adenocarcinomas (PDA) are complex heterocellular tumours characterised by extensive desmoplasia. Tumour and stromal host cells actively engage to establish reciprocal signalling loops, which drive cancer progression, resistance to treatment and evasion of immune surveillance. However, the specificity and directionality of these interactions are incompletely characterised. We have previously shown that tumour cells expressing the main oncogenic driver (KRASG12D) co-opt stromal f",{"id":904,"funder":7,"programme":8,"title":905,"piName":14,"institution":906,"country":129,"year":13,"amount":70,"abstract":907},"cordis-european-research-council-award-770889","Increasing the Spatial Correlation of Logical Units of Data to Enable an Ultra-Low Latency Internet","KUNGLIGA TEKNISKA HOEGSKOLAN","The cloud computing infrastructure that logically centralizes data storage and computation for many different actors is a prime example of a key societal system. A number of time-critical applications deployed in the cloud infrastructure have to provide high reliability and throughput, along with guaranteed low latency for delivering data. This low latency guarantee is sorely lacking today, with the so-called tail-latency of slowest responses in popular cloud services being several orders of mag",{"id":909,"funder":7,"programme":8,"title":910,"piName":14,"institution":460,"country":12,"year":13,"amount":911,"abstract":912},"cordis-european-research-council-award-771012","Tundra biogenic volatile emissions in the 21st century","€2,347,668","Biogenic volatile organic compounds (BVOCs) influence atmospheric oxidation causing climate feedback thought to be especially significant in remote areas with low anthropogenic emissions, such as the Arctic. Still, we do not understand the dynamics and impact of climatic and biotic BVOC emission drivers in arctic and alpine tundra, which are highly temperature-sensitive BVOC sources.TUVOLU will redefine tundra BVOC emission estimates to account for rapid and dramatic climate warming accompanied ",{"id":914,"funder":7,"programme":8,"title":915,"piName":14,"institution":815,"country":483,"year":13,"amount":916,"abstract":917},"cordis-european-research-council-award-771874","Law, Governance and Space: Questioning the Foundations of the Republican Tradition","€1,994,326","Administrative professionalization is the hallmark of a modern state, but its origins contain a dilemma. Why there were no offices in ancient Rome? How is it possible that it nevertheless formed the model for the Western administrative state? The purpose of this project is to challenge earlier research and to propose a new model of the Roman Republican governance that integrates domestic and private space and to reinterpret its links with the Republican tradition.The significance of these issues",{"id":919,"funder":7,"programme":8,"title":920,"piName":14,"institution":116,"country":117,"year":13,"amount":921,"abstract":922},"cordis-european-research-council-award-771136","Lifting Methods for Global Matching Problems","€1,675,640","This proposal presents a research program aimed at breaking new ground in theoretical, algorithmic and practical aspects of the notoriously difficult matching problems. The main goal is developing a unified algorithmic framework for matching problems that enjoys theoretical guarantees and high practical value for ``real-life'' applications.The core methodological aspect is the modelling of matching problems as high-dimensional, lifted convex problems that can be efficiently approximated. We pres",{"id":924,"funder":7,"programme":8,"title":925,"piName":14,"institution":116,"country":117,"year":13,"amount":926,"abstract":927},"cordis-european-research-council-award-772839","Probabilistically Checkable Proofs, Agreement Tests, and High Dimensional Expanders","€1,512,035","PCPs capture a striking local to global phenomenon in which a global object such as an NP witness can be checked using local constraints, and its correctness is guaranteed even if only a fraction of the constraints are satisfied. PCPs are tightly related to hardness of approximation. The relation is essentially due to the fact that exact optimization problems can be reduced to their approximation counterparts through this local to global connection.We view this local to global connection is a ty",{"id":929,"funder":7,"programme":8,"title":930,"piName":14,"institution":931,"country":21,"year":13,"amount":932,"abstract":933},"cordis-european-research-council-award-769994","Linking Latin. Building a Knowledge Base of Linguistic Resources for Latin","UNIVERSITA CATTOLICA DEL SACRO CUORE","€1,984,500","Although the research area dealing with building, sharing and exploiting linguistic resources and tools for automatic processing of Latin (and, more generally, of ancient languages) has seen a large growth across the last decade, linguistic resources for Latin are still not interoperable. This means that linguistic information is split up in many products that just do not talk to each other.Such a situation results in poor exploitation of the richness provided by all those digital objects for La",{"id":935,"funder":7,"programme":8,"title":936,"piName":14,"institution":937,"country":117,"year":13,"amount":938,"abstract":939},"cordis-european-research-council-award-770951","The Claustrum: A Circuit Hub for Attention","THE HEBREW UNIVERSITY OF JERUSALEM","€1,995,000","Our senses face a constant barrage of information. Hence, understanding how our brain enables us to attend to relevant stimuli, while ignoring distractions, is of increasing biomedical importance. Recently, I discovered that the claustrum, a multi-sensory hub and recipient of extensive neuromodulatory input, enables resilience to distraction.In my ERC project, I will explore the mechanisms underlying claustral mediation of resilience to distraction and develop novel approaches for assessing and ",{"id":941,"funder":7,"programme":8,"title":942,"piName":14,"institution":943,"country":141,"year":13,"amount":944,"abstract":945},"cordis-european-research-council-award-772051","Harnessing clonal evolution in chronic lymphocytic leukemia","FONDAZIONE PER L'ISTITUTO ONCOLOGICO DI RICERCA (IOR)","€1,940,000","Chronic lymphocytic leukemia (CLL), the most common leukemia in adults, is addicted of interactions with the microenvironment. The B-cell receptor (BCR) is one of the most important surface molecules that CLL cells use to gain oncogenic signals from the microenvironment. The critical role of BCR signaling for the pathogenesis of CLL is supported by the therapeutic success of ibrutinib, a targeted agent that disrupts the BCR pathway. Beside microenvironment-promoted oncogenic signals, the biology",{"id":947,"funder":7,"programme":8,"title":948,"piName":14,"institution":292,"country":93,"year":13,"amount":949,"abstract":950},"cordis-european-research-council-award-770835","Building biological computers from bacterial populations","€1,998,025","Biosensors detect compounds using a biological component combined with a physio-chemical detector. Using synthetic biology, we can now engineer bacteria into whole-cell biosensors where sensing, transduction and output occur within the living cell. Applications include the detection of harmful environmental agents, bioprocess monitoring, and detecting medically relevant biomarkers. As we move towards more sophisticated applications, single channel read-out will be replaced with sensors that have",{"id":952,"funder":7,"programme":8,"title":953,"piName":14,"institution":954,"country":34,"year":13,"amount":955,"abstract":956},"cordis-european-research-council-award-772332","Housing, Finance and the Macroeconomy, 1870-2015","INSTITUT FUER WELTWIRTSCHAFT LEIBNIZ ZENTRUM ZUR ERFORSCHUNG GLOBALER OKONOMISCHER HERAUSFORDERUNGEN","€1,536,130","Popular wisdom has it that no other investment is as ‘safe as houses’. Households have rigorously followed this investment advice. At the beginning of the 20th century, home ownership was the exception, not the rule. 100 years later, about two thirds of Europeans own the houses they live in. Homes have become the most important asset of households and mortgage loans have driven the growth of the financial sector, becoming its main asset. In the 2008 crisis, the housing market was the epicentre o",{"id":958,"funder":7,"programme":8,"title":959,"piName":14,"institution":665,"country":93,"year":13,"amount":960,"abstract":961},"cordis-european-research-council-award-772946","Laws of Social Reproduction","€1,999,542","Feminist scholars have long demonstrated the invisibility of womens reproductive labour, performed in bearing and raising children, maintaining households and socially sustaining male labour. Mainstream international economic institutions acknowledge unpaid care work as an obstacle to womens economic empowerment. Sustainable Development Goal 5.4 requires that unpaid care and domestic work be recognised through provision of public services and shared responsibility in the family. However the worl",{"id":963,"funder":7,"programme":8,"title":964,"piName":14,"institution":655,"country":129,"year":13,"amount":965,"abstract":966},"cordis-european-research-council-award-771872","Urban Sharing: Sustainability and Institutionalisation Pathways","€1,999,948","Urban sharing of assets has emerged as a prospective solution to sustainability challenges faced by cities. But, its sustainability potential and institutionalisation pathways have not been systematically examined. Urban Sharing aims to examine, test and advance knowledge about urban sharing organisations (USOs) across 5 cities from 5 continents: Amsterdam, Toronto, São Paolo, Seoul and Melbourne by undertaking a novel multi- and inter-disciplinary study with three objectives:1. DESIGN: To exami",{"id":968,"funder":7,"programme":8,"title":969,"piName":14,"institution":970,"country":256,"year":13,"amount":971,"abstract":972},"cordis-european-research-council-award-771483","Attempts to Control the End of Life in People with Dementia: Two-level Approach to Examine Controversies","ACADEMISCH ZIEKENHUIS LEIDEN","€1,988,972","In dementia at the end of life, cognitive and physical decline imply that control is typically lost. CONT-END will examine control in the context of three emerging interventions which contain a controversial element of striving for control in the process of dying with dementia: advance care planning of the end of life, use of new technology to monitor symptoms when unable to self-report, and euthanasia. To perform outstanding research, the proposed research examines control at the level of clini",{"id":974,"funder":7,"programme":8,"title":975,"piName":14,"institution":482,"country":483,"year":13,"amount":976,"abstract":977},"cordis-european-research-council-award-772510","Small Molecule Activation by Main-Group Compounds","€1,424,190","Many basic chemical processes involve the activation of small unreactive molecules, such as hydrogen, nitrogen, ammonia, water and carbon dioxide, by transition-metal-based catalysts or by enzymes. This proposal focusses on the interesting and recently observed possibility to perform similar transformations with main-group compounds that consist entirely of cheap earth-abundant elements. The proposed research is split into four work packages of which the first investigates the mechanisms by whic",{"id":979,"funder":7,"programme":8,"title":980,"piName":14,"institution":292,"country":93,"year":13,"amount":981,"abstract":982},"cordis-european-research-council-award-771493","Local quantum operations achieved through the motion of spins","€2,264,167","Spins have long been appreciated as versatile tools for studying coherent quantum phenomena in a range of materials and have emerged as powerful components for the development of technologies such as quantum information processors and sensors. Results from the past 5 years have shown that spins can exhibit exceptionally long coherence lifetimes (seconds for the electron spin, hours for the nuclear spin), and can be measured with high fidelity in a single shot and at the single spin level. These ",{"id":984,"funder":7,"programme":8,"title":985,"piName":14,"institution":797,"country":519,"year":13,"amount":986,"abstract":987},"cordis-european-research-council-award-772452","Nano-physiology of small glutamatergic axon terminals","€1,994,025","We will reveal the neuronal mechanisms of fundamental hippocampal and axonal functions using direct patch clamp recordings from the small axon terminals of the major glutamatergic afferent and efferent pathways of the dentate gyrus region. Specifically, we will investigate the intrinsic axonal properties and unitary synaptic functions of the axons in the dentate gyrus that originate from the entorhinal cortex, the hilar mossy cells and the hypothalamic supramammillary nucleus. The fully controll",{"id":989,"funder":7,"programme":8,"title":990,"piName":14,"institution":991,"country":34,"year":13,"amount":14,"abstract":992},"cordis-european-research-council-award-772027","Spectroscopy in cells  with tailored in-vivo labelling strategies  and multiply addressable nano-structural probes","UNIVERSITAT KONSTANZ","This project proposes to combine complementary spectroscopic approaches and push the domain of molecular spectroscopy for structural biology and biophysics into the living cell. Non-invasive molecular spectroscopy to probe protein dynamics and structures at the molecular level is essential for unravelling one of the most challenges in Chemical Biology - the complex physical mechanism of life. Of particular interest are electron paramagnetic resonance (EPR) distance measurements in the nanometer ",{"id":994,"funder":7,"programme":8,"title":995,"piName":14,"institution":655,"country":129,"year":13,"amount":996,"abstract":997},"cordis-european-research-council-award-771121","Targeting Meniscus Degradation in Osteoarthritis","€1,973,764","My goal is to determine the molecular degradation of meniscus tissue, a “new” disease that leads to degenerative meniscus tears and osteoarthritis (OA). My prior research has revealed that meniscus tears are a frequent entity in OA, not typically caused by knee trauma. By focusing on the meniscus, we aim to discover novel biomarkers and new targets for pharmaceutical intervention against OA, by preventing meniscus degradation and stimulating its regeneration. In our ageing population, the burden",{"id":999,"funder":7,"programme":8,"title":1000,"piName":14,"institution":1001,"country":111,"year":13,"amount":1002,"abstract":1003},"cordis-european-research-council-award-772418","Development and use of an integrated in silico-in vitro mesofluidics system for tissue engineering","UNIVERSITE DE LIEGE","€2,161,750","Tissue Engineering (TE) refers to the branch of medicine that aims to replace or regenerate functional tissue or organs using man-made living implants. As the field is moving towards more complex TE constructs with sophisticated functionalities, there is a lack of dedicated in vitro devices that allow testing the response of the complex construct as a whole, prior to implantation.  Additionally, the knowledge accumulated from mechanistic and empirical in vitro and in vivo studies is often underu",{"id":1005,"funder":7,"programme":8,"title":1006,"piName":14,"institution":1007,"country":93,"year":13,"amount":1008,"abstract":1009},"cordis-european-research-council-award-772345","Women’s cancers: do variations in patterns of care explain the world-wide inequalities in survival and avoidable premature deaths?","LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER","€1,996,483","Opening the World Cancer Congress in Paris in November 2016, President François Hollande insisted that women should be at the heart of cancer control, “because they are victims of inequality in access to prevention, treatment and screening in every country in the world.” Breast, ovarian and cervical cancers are a major public health problem world-wide. Each year, approximately 2.5 million women are diagnosed with one of these cancers, and 900,000 women die from them, mainly in low- and middle-in",{"id":1011,"funder":7,"programme":8,"title":1012,"piName":14,"institution":1013,"country":431,"year":13,"amount":14,"abstract":1014},"cordis-european-research-council-award-772464","Third Strategy in Tissue Engineering – Functional microfabricated multicellular spheroid carriers for tissue engineering and regeneration","TECHNISCHE UNIVERSITAET WIEN","The field of tissue engineering (TE) pursues a noble goal, driven by the urgent need for tissue and organ repair. It is represented by a fairly large and extremely interdisciplinary scientific community. However, so far TE was not able to deliver to the expectations, with only a few examples of successful clinical translation mostly restricted to a particular disease or tissue type. Despite the fact that all major fundamental bottlenecks of conventional TE strategies have long been identified, a",{"id":1016,"funder":7,"programme":8,"title":1017,"piName":14,"institution":650,"country":256,"year":13,"amount":70,"abstract":1018},"cordis-european-research-council-award-771497","Evolution and Variability of Climate Sensitivity and Polar Amplification during CeNozoic Warm Climates SPANC","Forecasting the magnitude of future global warming is among the great scientific challenges. Model estimates of long-term warming resulting from a doubling of the CO2 concentration relative to the pre-industrial era range between 1.5 and 4.5 °C. The large uncertainty in this Equilibrium Climate Sensitivity (ECS) may represent the difference between the melting or conservation of large continental ice sheets, and between habitable and inhabitable regions. SPANC will quantify ECS through accurate ",{"id":1020,"funder":7,"programme":8,"title":1021,"piName":14,"institution":1022,"country":123,"year":13,"amount":1023,"abstract":1024},"cordis-european-research-council-award-771310","Partial Ionisation: Two-Fluid Approach","INSTITUTO DE ASTROFISICA DE CANARIAS","€1,968,750","PI2FA proposal’s overarching aim is to make a major breakthrough in our understanding of the magnetised solar chromosphere under a novel frame of a multi-fluid plasma theory. Future large-aperture solar telescopes, EST and DKIST, will have among their primary focus observations of chromospheric magnetic fields. The correct interpretation of solar data requires sophisticated theories. The solar atmosphere is made of strongly stratified, weakly ionised and not completely collisionally coupled plas",{"id":1026,"funder":7,"programme":8,"title":1027,"piName":14,"institution":655,"country":129,"year":13,"amount":70,"abstract":1028},"cordis-european-research-council-award-770992","Genetic variation exposes regulators of blood cell formation in vivo in humans","The human hematopoietic system is a paradigmatic, stem cell-maintained organ with enormous cell turnover. Hundreds of billions of new blood cells are produced each day. The process is tightly regulated, and susceptible to perturbation due to genetic variation. In this project, we will explore an innovative, population-genetic approach to find regulators of blood cell formation. Unlike traditional studies on hematopoiesis in vitro or in animal models, we will exploit natural genetic variation to ",{"id":1030,"funder":7,"programme":8,"title":1031,"piName":14,"institution":292,"country":93,"year":13,"amount":1032,"abstract":1033},"cordis-european-research-council-award-771550","How does the brain organize sounds into auditory scenes?","€1,999,999","Real-world listening involves making sense of the numerous competing sound sources that exist around us. The neuro-computational challenge faced by the brain is to reconstruct these sources from the composite waveform that arrives at the ear; a process known as auditory scene analysis. While young normal hearing listeners can parse an auditory scene with ease, the neural mechanisms that allow the brain to do this are unknown – and we are not yet able to recreate them with digital technology. Hea",{"id":1035,"funder":7,"programme":8,"title":1036,"piName":14,"institution":1037,"country":34,"year":13,"amount":1038,"abstract":1039},"cordis-european-research-council-award-772752","Single Molecule Analytical Raman Tools based on DNA nanostructures","UNIVERSITAET POTSDAM","€1,996,476","The monitoring of single molecule reactions promises unrivalled insight into chemical reaction mechanisms, but represents one of the most challenging tasks in chemistry. Surface-enhanced Raman scattering (SERS) is a particularly attractive single molecule (SM) technique due to its high chemical specificity, which allows to directly detect relevant intermediates and molecular subpopulations. However, SM-SERS is still at a premature state due to the highly challenging task to place single molecule",{"id":1041,"funder":7,"programme":8,"title":1042,"piName":14,"institution":1043,"country":1044,"year":13,"amount":1045,"abstract":1046},"cordis-european-research-council-award-772346","Towards Unification of Algorithmic Tools","UNIWERSYTET WARSZAWSKI","PL","€1,510,800","Over last 50 years, extensive algorithmic research gave rise to a plethora of fundamental results. These results equipped us with increasingly better solutions to a number of core problems. However, many of these solutions are incomparable. The main reason for that is the fact that many cutting-edge algorithmic results are very specialized in their applicability. Often, they are limited to particular parameter range or require different assumptions. A natural question arises: is it possible to g",{"id":1048,"funder":7,"programme":8,"title":1049,"piName":14,"institution":821,"country":93,"year":13,"amount":1050,"abstract":1051},"cordis-european-research-council-award-772353","Dictatorship as experience: a comparative history of everyday life and the 'lived experience' of dictatorship in Mediterranean Europe (1922-1975)","€1,497,724","‘Dictatorship’ conventionally conjures an image of a charismatic, dogmatic (male) leader ruling from on high, through magnetism, propaganda and violence, a pliant population alternately rallied in fervent support or cowed into submission. Such images belie the crucial reality that dictatorships were experienced subjectively – and in some respects put into practice - by the men, women and children who lived (through) them.  Individuals encountered the dictatorial state not only in official polici",{"id":1053,"funder":7,"programme":8,"title":1054,"piName":14,"institution":466,"country":141,"year":13,"amount":1055,"abstract":1056},"cordis-european-research-council-award-770754","Decoding the Mechanics of Metals by Coarse-Grained Atomistics","€1,995,128","\"First principles and bottom-up have become buzz words across scientific and engineering disciplines when it comes to the discovery, prediction and understanding of material properties and their link to processing and microstructure. Reality, however, teaches us that in the foreseeable future computational resources will be insufficient to apply predictive techniques such as quantum mechanics or atomistics to the technologically most relevant length and time scales - far above nanometers and nan",{"id":1058,"funder":7,"programme":8,"title":1059,"piName":14,"institution":1060,"country":34,"year":13,"amount":810,"abstract":1061},"cordis-european-research-council-award-771295","Sulfur-based solutions for the selective functionalization of organic substrates","GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS","The increasing demand of complex organic molecules, either by their biological activity or technical interest, and the need for the development of sustainable chemical processes are opening a new period in Organic Synthesis, which is mainly focused on the discovery of novel transformations that more intensively explore concepts such as atom-economy and redox-neutrality. As part of this trend, the development new reagents capable to transfer new functional groups at the desired positions of advan",{"id":1063,"funder":7,"programme":8,"title":1064,"piName":14,"institution":815,"country":483,"year":13,"amount":1065,"abstract":1066},"cordis-european-research-council-award-771113","Found in Translation – Natural Language Understanding with Cross-Lingual Grounding","€1,817,622","Natural language understanding is the holy grail of computational linguistics and a long-term goal in research on artificial intelligence. Understanding human communication is difficult due to the various ambiguities in natural languages and the wide range of contextual dependencies required to resolve them.  Discovering the semantics behind language input is necessary for proper interpretation in interactive tools, which requires an abstraction from language-specific forms to language-independe",{"id":1068,"funder":7,"programme":8,"title":1069,"piName":14,"institution":862,"country":256,"year":13,"amount":70,"abstract":1070},"cordis-european-research-council-award-772663","The MAgnetic field in the GALaxy, using Optical Polarization of Stars","What makes our Galaxy’s ecosystem so fascinating is the complex interactions between its components: stars, gas, dust, magnetic fields, and cosmic rays. Of these components, the Galactic magnetic field (GMF) may well be the most enigmatic. Only partially observable through indirect means, its study relies heavily on modeling, almost exclusively using line-of-sight integrated radio-polarimetric data.  Although much has been learned, many questions are still unanswered especially about the turbule",{"id":1072,"funder":7,"programme":8,"title":1073,"piName":14,"institution":305,"country":93,"year":13,"amount":1074,"abstract":1075},"cordis-european-research-council-award-771411","Neuronal regulation of CNS myelin plasticity","€1,999,729","Myelin is essential for normal brain function, as it provides fast signal transmission, promotes synchronisation of neuronal signals and helps to maintain neuronal function. Alterations in myelination are increasingly being implicated as a mechanism for sensory-motor learning. The importance of myelin becomes evident in diseases, such as multiple sclerosis (MS), where myelin damage causes cognitive and motor disability. Moreover, recent studies have highlighted the contribution of myelin to many",{"id":1077,"funder":7,"programme":8,"title":1078,"piName":14,"institution":1079,"country":483,"year":13,"amount":1080,"abstract":1081},"cordis-european-research-council-award-771168","The integration of cell signalling and  mechanical forces in vascular morphology","ABO AKADEMI","€1,919,599","Cardiovascular diseases represent the principal worldwide medical challenge of the 21st century (WHO), and new concepts to treat, predict and even prevent these diseases are needed. Structural remodelling of the vasculature in response to changes in blood flow is important to maintain mechanical homeostasis, and many diseases are related to defects in tissue morphology and mechanical imbalance. Signalling between endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) via the Notch path",{"id":1083,"funder":7,"programme":8,"title":1084,"piName":14,"institution":650,"country":256,"year":13,"amount":14,"abstract":1085},"cordis-european-research-council-award-771290","Enhancing Capabilities? Rethinking Work-life Policies and their Impact from a New Perspective","We have witnessed significant work-life policy advancements designed to help men and women more equally combine employment with other spheres of life in recent decades, yet gender inequality persists. Improving gender equality in work-life balance is therefore high on policy agendas throughout Europe. Decades of research in this area have produced key insights but work-family theories fail to sufficiently explain the tenacity of this inequality. Earlier applications of a capabilities approach to",{"id":1087,"funder":7,"programme":8,"title":1088,"piName":14,"institution":262,"country":256,"year":13,"amount":1089,"abstract":1090},"cordis-european-research-council-award-773264","Lewis acid promoted copper catalysis to functionalise and dearomatise arenes","€1,999,398","Aromatic compounds are cheap and readily available, making them ideal starting materials for the synthesis of chiral alicyclic compounds, important synthetic building blocks for both natural product synthesis and drug discovery. However, general strategies for efficient, catalytic dearomatisation of aromatics are lacking. This proposal aims to fill this gap by developing general asymmetric methods for dearomatisation reactions of both electron-rich and electron-deficient aromatics. It relies on ",{"id":1092,"funder":7,"programme":8,"title":1093,"piName":14,"institution":1094,"country":256,"year":13,"amount":1095,"abstract":1096},"cordis-european-research-council-award-771292","The Digital Ludeme Project: Modelling the Evolution of Traditional Games","UNIVERSITEIT MAASTRICHT","€1,997,244","The development of games goes hand in hand with the development of human culture. Games offer a rich window of insight into our cultural past, but early examples were rarely documented and our understanding of them is incomplete. While there has been considerable historical research into games and their use as tools of cultural analysis, much is based on the interpretation of partial evidence with little mathematical analysis. This project will use modern computational techniques to help fill th",{"id":1098,"funder":7,"programme":8,"title":1099,"piName":14,"institution":1100,"country":93,"year":13,"amount":1101,"abstract":1102},"cordis-european-research-council-award-769130","A holistic approach to large-scale structure cosmology","LIVERPOOL JOHN MOORES UNIVERSITY","€1,725,982","The standard model of cosmology, the ɅCDM model, is remarkably successful at explaining a wide range of observations of our Universe.  However, it is now being subjected to much more stringent tests than ever before, and recent large-scale structure (LSS) measurements appear to be in tension with its predictions.  Is this tension signalling that new physics is required?  For example, time-varying dark energy, or perhaps a modified theory of gravity?  A contribution from massive neutrinos?  Befor",{"id":1104,"funder":7,"programme":8,"title":1105,"piName":14,"institution":1106,"country":34,"year":13,"amount":14,"abstract":1107},"cordis-european-research-council-award-772299","Metal-Mediated Methods for the Functionalization of White Phosphorus (P4)","UNIVERSITAET REGENSBURG","Organophosphorus compounds are an important and industrially relevant class of molecules with numerous uses, e.g. as reagents in organic synthesis, ligands in catalytically active metal complexes, and in pest control. State-of-the-art synthesis methods for all these valuable and useful compounds rely on an atom inefficient and hazardous multi-step procedure involving the oxidation of white phosphorus (P4) with toxic chlorine gas. Less wasteful and more environmentally benign methods are highly d",{"id":1109,"funder":7,"programme":8,"title":1110,"piName":14,"institution":1111,"country":34,"year":13,"amount":1112,"abstract":1113},"cordis-european-research-council-award-772994","Dynamic regulation of feeding behaviors in health and disease by top-down control of hypothalamic networks","KLINIKUM DER UNIVERSITAET ZU KOELN","€1,875,000","Feeding behaviors represent a complex set of crucial for survival abilities required to meet upcoming nutritional demands. Eating disorders, such as anorexia nervosa, are widespread, difficult to treat and extremely dangerous, displaying the highest mortality rate of all psychiatric disorders and a very high relapse rate. Mechanisms of onset, progression and relapse of eating disorders are unknown. Feeding behaviors are regulated by hypothalamus, an evolutionary conservative brain region. While ",{"id":1115,"funder":7,"programme":8,"title":1116,"piName":14,"institution":1013,"country":431,"year":13,"amount":1117,"abstract":1118},"cordis-european-research-council-award-771527","Foundations and Tools for Client-Side Web Security","€1,990,000","The constantly increasing number of attacks on web applications shows how their rapid development has not been accompanied by adequate security foundations and demonstrates the lack of solid security enforcement tools.  Indeed, web applications expose a gigantic attack surface, which hinders a rigorous understanding and enforcement of security properties.  Hence, despite the worthwhile efforts to design secure web applications, users for a while will be confronted with vulnerable, or maliciously",{"id":1120,"funder":7,"programme":8,"title":1121,"piName":14,"institution":110,"country":111,"year":13,"amount":1122,"abstract":1123},"cordis-european-research-council-award-772649","The ubiquitin system in RAS-driven disease","€1,999,796","The RAS pathway is the most frequently activated signaling node in human disease. Despite intensive efforts, effective therapeutic strategies for RAS-driven disease remain daunting. Elucidation of the mechanisms of RAS activation promises to lead toward novel therapeutic approaches to inhibit RAS activity, and may permit identification of patients who might benefit from RAS pathway inhibitors. Our preliminary studies show that reversible ubiquitylation controls RAS activity by altering its inter",200,{"programme":8,"total":1126,"withPiName":1127,"firstYear":1128,"lastYear":1129,"countryCount":1130,"perYear":1131,"topInstitutions":1171,"topCountries":1239},4499,349,2014,2027,45,[1132,1134,1137,1140,1143,1145,1148,1151,1154,1157,1160,1163,1166,1169],{"year":1128,"count":1133},303,{"year":1135,"count":1136},2015,335,{"year":1138,"count":1139},2016,322,{"year":1141,"count":1142},2017,327,{"year":13,"count":1144},403,{"year":1146,"count":1147},2019,300,{"year":1149,"count":1150},2020,277,{"year":1152,"count":1153},2021,321,{"year":1155,"count":1156},2022,364,{"year":1158,"count":1159},2023,359,{"year":1161,"count":1162},2024,366,{"year":1164,"count":1165},2025,375,{"year":1167,"count":1168},2026,416,{"year":1129,"count":1170},31,[1172,1175,1178,1181,1184,1187,1190,1192,1194,1197,1198,1201,1204,1206,1208,1211,1214,1217,1220,1223,1225,1228,1231,1234,1237],{"name":1173,"count":1174},"Centre National de la Recherche Scientifique CNRS",229,{"name":1176,"count":1177},"University of Oxford",89,{"name":1179,"count":1180},"Weizmann Institute of Science",78,{"name":1182,"count":1183},"University of Cambridge",77,{"name":1185,"count":1186},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",63,{"name":1188,"count":1189},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",55,{"name":1191,"count":1189},"Institut National de la Sante Et de la Recherche Medicale",{"name":1193,"count":1189},"Kobenhavns Universitet",{"name":1195,"count":1196},"Universiteit Utrecht",51,{"name":40,"count":1196},{"name":1199,"count":1200},"Tel Aviv University",49,{"name":1202,"count":1203},"The Hebrew University of Jerusalem",43,{"name":1205,"count":1203},"Universiteit Gent",{"name":1207,"count":1203},"Universiteit van Amsterdam",{"name":1209,"count":1210},"Ludwig-Maximilians-Universitaet Muenchen",42,{"name":1212,"count":1213},"Technische Universitaet Muenchen",41,{"name":1215,"count":1216},"Eidgenoessische Technische Hochschule Zuerich",40,{"name":1218,"count":1219},"Universitat Wien",39,{"name":1221,"count":1222},"Helsingin Yliopisto",38,{"name":1224,"count":1222},"Technische Universiteit Delft",{"name":1226,"count":1227},"Katholieke Universiteit Leuven",37,{"name":1229,"count":1230},"Universitetet I Oslo",36,{"name":1232,"count":1233},"École Polytechnique Fédérale de Lausanne",34,{"name":1235,"count":1236},"The University of Edinburgh",32,{"name":1238,"count":1170},"Lunds Universitet",[1240,1242,1244,1246,1248,1250,1252,1254,1255,1257,1259,1261,1263,1265,1267,1269,1271,1273,1274,1276,1279,1282,1284,1287,1290],{"name":34,"count":1241},810,{"name":93,"count":1243},559,{"name":69,"count":1245},490,{"name":256,"count":1247},428,{"name":123,"count":1249},315,{"name":21,"count":1251},267,{"name":117,"count":1253},219,{"name":141,"count":1124},{"name":129,"count":1256},170,{"name":111,"count":1258},166,{"name":431,"count":1260},146,{"name":12,"count":1262},127,{"name":483,"count":1264},94,{"name":165,"count":1266},85,{"name":299,"count":1268},82,{"name":734,"count":1270},68,{"name":27,"count":1272},47,{"name":418,"count":1230},{"name":519,"count":1275},24,{"name":1277,"count":1278},"EL",22,{"name":1280,"count":1281},"US",21,{"name":1044,"count":1283},20,{"name":1285,"count":1286},"TR",14,{"name":1288,"count":1289},"LU",13,{"name":1291,"count":1292},"EE",8]