[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-consolidator-grant-2019":3,"awarded-stats-erc-consolidator-grant":1106},{"awarded":4,"total":1105},[5,16,23,30,37,44,51,57,64,71,78,84,90,97,103,109,114,121,128,135,141,147,152,158,164,169,175,182,189,194,200,206,211,217,222,227,232,238,244,250,256,262,268,274,279,286,292,297,303,308,313,318,324,330,335,340,346,352,358,362,368,373,379,385,391,397,403,407,412,417,423,429,434,440,446,452,457,462,468,473,479,483,488,492,497,503,508,514,519,525,530,535,541,547,553,557,562,566,572,577,583,588,593,599,604,609,614,619,625,630,635,641,646,650,656,661,666,671,676,681,687,693,698,703,707,712,717,724,730,734,739,743,748,753,759,764,770,775,781,786,793,798,804,809,814,820,826,831,835,840,845,850,856,861,866,870,875,880,885,891,897,901,907,912,918,923,928,932,938,943,950,955,961,966,972,977,983,988,994,999,1005,1010,1016,1022,1027,1032,1037,1042,1047,1052,1056,1061,1065,1070,1075,1080,1086,1091,1095,1100],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-818366","European Research Council","ERC Consolidator Grant","Classical Influences and Irish Culture",null,"AARHUS UNIVERSITET","DK",2019,"€1,888,592","The hypothesis of this project is that Ireland has a unique and hitherto underexplored history of cultural engagement with models from ancient Greece and Rome. Unlike Britain and mainland Europe, Ireland was never part of the Roman Empire. Yet the island has an extraordinarily vibrant tradition of classical learning that dates back to its earliest recorded literature, and is unparalleled in other northern European countries. Research for this project will address why this is the case, by examini",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":20,"year":13,"amount":21,"abstract":22},"cordis-european-research-council-award-811363","Collisional excitation of interstellar molecules: towards reactive systems","UNIVERSITE DE RENNES","FR","€1,802,625","Accurate determination of physical conditions of interstellar molecular clouds is a crucial step to better understand the life cycle of the interstellar matter and particularly the formation of stars and planets as well as the synthesis of organic molecules that may lead to emergence of life in the universe. A key parameter for the determination of these conditions from interstellar spectra is the calculation of accurate collisional rate coefficients of interstellar molecules with the most abund",{"id":24,"funder":7,"programme":8,"title":25,"piName":10,"institution":26,"country":27,"year":13,"amount":28,"abstract":29},"cordis-european-research-council-award-817799","New Horizons in Quantum Matter: From Critical Fluids to High Temperature Superconductivity","WEIZMANN INSTITUTE OF SCIENCE","IL","€1,515,400","Understanding the low-temperature behavior of quantum correlated materials has long been one of the central challenges in condensed matter physics. Such materials exhibit a number of interesting phenomena, such as anomalous transport behavior, complex phase diagrams, and high-temperature superconductivity. However, their understanding has been hindered by the lack of suitable theoretical tools to handle such strongly interacting quantum ``liquids.'' Recent years have witnessed a wave of renewed ",{"id":31,"funder":7,"programme":8,"title":32,"piName":10,"institution":33,"country":34,"year":13,"amount":35,"abstract":36},"cordis-european-research-council-award-817908","Spatial fractionation of the dose in proton therapy: a novel therapeutic approach","UNIVERSIDAD DE SANTIAGO DE COMPOSTELA","ES","€1,997,870","Radiotherapy (RT) is one of the most frequently used methods for cancer treatment (above 50% of patients will receive RT). Despite remarkable advancements, the dose tolerances of normal tissues continue to be the main limitation in RT. Finding novel approaches that allow increasing normal tissue resistance is of utmost importance. This would make it possible to escalate tumour dose, resulting in an improvement in cure rate. With this aim, I propose a new approach, called proton minibeam radiatio",{"id":38,"funder":7,"programme":8,"title":39,"piName":10,"institution":40,"country":41,"year":13,"amount":42,"abstract":43},"cordis-european-research-council-award-817535","Navigating the most challenging habitats on earth: unravelling the architecture of a universal compass system","LUNDS UNIVERSITET","SE","€1,994,225","When lost in the desert at night, or in dense forests, people tend to walk in circles. This is because the seemingly simple act of walking in a straight line involves a complex interplay of various sensory modalities, the motor system and cognition. A ball-rolling dung beetle released in the same type of uncharted territory, does not walk in circles, but rather keeps steadfastly to a chosen bearing. The main goal of this project is unravel the sensory and neuronal architecture of the newly disco",{"id":45,"funder":7,"programme":8,"title":46,"piName":10,"institution":47,"country":48,"year":13,"amount":49,"abstract":50},"cordis-european-research-council-award-819227","Future Migration as Present Fact","INSTITUTT FOR FREDSFORSKNING","NO","€1,999,672","The springboard for this project is a striking statistic: half of all young adults in West Africa wish to leave their own country and settle elsewhere. Yet, the vast majority never depart. This discrep-ancy raises a fundamental question: if migration is desired, but never materializes, what are the consequences? The project breaks with traditional approaches by shifting the object of study from observed migration in the present to imagined migration in the future. Although such future migration ",{"id":52,"funder":7,"programme":8,"title":53,"piName":10,"institution":54,"country":27,"year":13,"amount":55,"abstract":56},"cordis-european-research-council-award-818450","Methane related iron reduction processes in sediments: Hidden couplings and their significance for carbon and iron cycles","BEN-GURION UNIVERSITY OF THE NEGEV","€2,000,000","About one-third of annual methane (CH4) emissions to the atmosphere originate from natural, nonanthropogenicsources. However, if all the naturally produced methane actually did reach the atmosphere, itslevels would increase by an order of magnitude, dwarfing anthropogenic CO2 emissions. Fortunately, naturalscavengers of this methane near its production zone limit its release. One of these scavengers, iron (Fe) oxide,can become a major sink for methane when sulfate concentrations are low. Methane",{"id":58,"funder":7,"programme":8,"title":59,"piName":10,"institution":60,"country":61,"year":13,"amount":62,"abstract":63},"cordis-european-research-council-award-817897","Sexual and gender contestations in everyday spaces and the possibilities of moving beyond opposition","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","IE","€1,988,652","BEYONDOPPOSITION will be the first large-scale, transnational study to consider the effects of recent Sexual and Gender Rights and Equalities (SGRE) on those who oppose them, by exploring opponents’ experiences of the transformation of everyday spaces. It will work beyond contemporary polarisations, creating new possibilities for social transformation. This cutting-edge research engages with the dramatically altered social and political landscapes in the late 20th and early 21st Century created ",{"id":65,"funder":7,"programme":8,"title":66,"piName":10,"institution":67,"country":68,"year":13,"amount":69,"abstract":70},"cordis-european-research-council-award-820074","Charting key molecules and mechanisms of human immune Dysregulation","ST. ANNA KINDERKREBSFORSCHUNG GMBH","AT","€1,999,263","The central challenge for the immune system is to efficiently recognize and neutralize foreign antigen while protecting self. If the latter fails, autoimmunity and\u002For autoinflammation may occur, as observed in many human diseases. Though several human genes involved in the process have been identified we still lack: i) a comprehensive appreciation of all contributing molecular pathways, ii) an understanding of the interplay and epistatic relationships among the various elements and iii) a satisf",{"id":72,"funder":7,"programme":8,"title":73,"piName":10,"institution":74,"country":75,"year":13,"amount":76,"abstract":77},"cordis-european-research-council-award-819155","Earth-like Planet Imaging with Cognitive computing","UNIVERSITE DE LIEGE","BE","€2,178,125","One of the most ambitious goals of modern astrophysics is to characterise the physical and chemical properties of rocky planets orbiting in the habitable zone of nearby Sun-like stars. Although the observation of planetary transits could in a few limited cases be used to reach such a goal, it is widely recognised that only direct imaging techniques will enable such a feat on a statistically significant sample of planetary systems. Direct imaging of Earth-like exoplanets is however a formidable c",{"id":79,"funder":7,"programme":8,"title":80,"piName":10,"institution":81,"country":34,"year":13,"amount":82,"abstract":83},"cordis-european-research-council-award-817661","The impact of highly magnetic neutron stars in the explosive and transient Universe","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","€2,263,148","The gravitational wave window is now open. It is then imperative to build quantitative models of neutron stars that use all the available tracers to constrain fundamental physics at the highest densities and magnetic fields. The most magnetic neutron stars, the magnetars, have been recently suggested to be powering a large variety of explosive and transient events. The enormous rotational power at birth, and the magnetic energy they can release via large flares, put the magnetars in the (yet) ha",{"id":85,"funder":7,"programme":8,"title":86,"piName":10,"institution":87,"country":20,"year":13,"amount":88,"abstract":89},"cordis-european-research-council-award-820079","COntinuous variables Quantum COmplex Networks","SORBONNE UNIVERSITE","€1,990,000","At different scales, from molecular systems to technological infrastructures, physical systems group in structures which are neither simply regular or random, but can be represented by networks with complex shape. Proteins in metabolic structures and the World Wide Web, for example, share the same kind of statistical distribution of connections of their constituents. In addition, the individual elements of natural samples, like atoms or electrons, are quantum objects. Hence replicating complex n",{"id":91,"funder":7,"programme":8,"title":92,"piName":10,"institution":93,"country":94,"year":13,"amount":95,"abstract":96},"cordis-european-research-council-award-818179","Engineering brain activity patterns for therapeutics of neuropsychiatric and neurological disorders","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","CH","€1,998,984","Neuropsychiatric and neurological disorders are complex dysfunctions of neuronal circuits. Their treatmenthas been limited by the lack of non-invasive methods for measuring the underlying circuit dysfunctions, andfor direct and localized modifications of these circuits. We propose minimally invasive technologies formeasuring brain activity and functional connectivity patterns, and for manipulating them directly in vivo tocorrect the abnormal behavioural phenotypes (in rodents with potential scal",{"id":98,"funder":7,"programme":8,"title":99,"piName":10,"institution":100,"country":34,"year":13,"amount":101,"abstract":102},"cordis-european-research-council-award-819404","Breaking barriers between Science and Heritage approaches to Levantine Rock Art through Archaeology, Heritage Science and IT","UNIVERSITAT DE BARCELONA","€1,991,178","LArcHer project aims at pioneering a new and more comprehensive way of understanding one of Europe’s most extraordinary bodies of prehistoric art, awarded Unesco World Heritage status in 1998: Levantine rock art (LRA). The ground-breaking nature of the project relies on combining a multidisciplinary (Archaeology, Heritage Science and IT) and multiscale approach (from microanalysis to landscape perspectives) to gain a holistic view of this art. It also aims at closing existing gaps between scienc",{"id":104,"funder":7,"programme":8,"title":105,"piName":10,"institution":106,"country":94,"year":13,"amount":107,"abstract":108},"cordis-european-research-council-award-818806","Therapeutic Allele Engineering: A novel technology for cell therapy","UNIVERSITAT BASEL","€2,397,082","We are currently witnessing a revolution in cell therapies that are routed in decades of basic research in genetics, cell biology and immunology. A deep understanding of mammalian, and in particular immune, cells is currently being translated into highly efficient cell-based therapeutics. Technologic breakthroughs in genetic and genome engineering are further fueling the generation of customized, high precision therapies that are based on cells as “smart drugs”. For instance, reprogramming immun",{"id":110,"funder":7,"programme":8,"title":111,"piName":10,"institution":93,"country":94,"year":13,"amount":112,"abstract":113},"cordis-european-research-council-award-817720","Non-Invasive Imaging of Nanoscale Electronic Transport","€2,491,490","Electronic transport in nanostructures and thin films shows a rich variety of physical effects that have been fundamental to the development of modern electronics and communication devices. The standard method for investigating electronic transport – resistance measurements – does not provide any information on the nanoscale current distribution in such structures. The lack of spatial information is unfortunate, because the current distribution plays a key role in many intriguing physical phenom",{"id":115,"funder":7,"programme":8,"title":116,"piName":10,"institution":117,"country":118,"year":13,"amount":119,"abstract":120},"cordis-european-research-council-award-819826","Self-organization of the cilium: the role of the tubulin code","FONDAZIONE HUMAN TECHNOPOLE","IT","€1,986,406","This project aims at understanding of the role of the tubulin code for self-organization of complex microtubule based structures. Cilia turn out to be the ideal structures for the proposed research.A cilium is a sophisticated cellular machine that self-organizes from many protein complexes. It plays motility, sensory, and signaling roles in most eukaryotic cells, and its malfunction causes pathologies. The assembly of the cilium requires intraflagellar transport (IFT), a specialized bidirectiona",{"id":122,"funder":7,"programme":8,"title":123,"piName":10,"institution":124,"country":125,"year":13,"amount":126,"abstract":127},"cordis-european-research-council-award-820188","Molecular control of actin network architecture and mechanics during cell shape changes","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","UK","€1,943,071","Precise control of shape is key to cell physiology, and cell shape deregulation is at the heart of many pathologies. As cell morphology is controlled by forces, studies integrating physics with biology are required to truly understand morphogenesis. NanoMechShape will take such an interdisciplinary approach to investigate the regulation of animal cell shape.In animal cells, actin networks are the primary determinants of shape. Most cell shape changes fall into two categories: 1) those driven by ",{"id":129,"funder":7,"programme":8,"title":130,"piName":10,"institution":131,"country":132,"year":13,"amount":133,"abstract":134},"cordis-european-research-council-award-819920","Integrating the tissue-specificity and chronology of hereditary renal cancer predisposition","KLINIKUM DER UNIVERSITAET ZU KOELN","DE","€1,998,698","Cancer cells undergo profound metabolic changes. However, little is known about whether and how metabolic changes drive cancer. The discovery that mutations of Tricarboxylic Acid (TCA) cycle enzymes in mitochondria predispose to cancer gives evidence that dysregulated metabolism could drive tumorigenesis. Amongst these, mutations in Fumarate Hydratase (FH) cause Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC), characterised by tumours of the skin and uterus, and renal cancer. Patients in",{"id":136,"funder":7,"programme":8,"title":137,"piName":10,"institution":138,"country":20,"year":13,"amount":139,"abstract":140},"cordis-european-research-council-award-817934","From mineral inclusions in zircon to continents: An in situ isotopic perspective on the evolution of the continental crust, the onset of plate tectonics and the development of a habitable Earth","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€1,999,500","The continental crust is the principal record of conditions on Earth during the past 4.4 billion years, yet how it formed and evolved through time remains unresolved. Zircon lies at the core of crustal evolution studies, and yet our knowledge has remained restricted to the geochemical information that can be extracted from this mineral with current techniques. This CoG moves the debate to a different scale analytically, to the scale of mineral inclusions encapsulated within zircons. A key motiva",{"id":142,"funder":7,"programme":8,"title":143,"piName":10,"institution":144,"country":132,"year":13,"amount":145,"abstract":146},"cordis-european-research-council-award-819933","A WORLD WITHOUT SCARS: Regenerating wounded skin rather than patching with scars","HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH","€1,997,890","Scars are a mystery. They rarely develop in lower vertebrates, where the norm is a complete regeneration of damaged tissues, but are frequent in mammals including humans. Scar phenotypes depend on different injury types, anatomic locations, age, gender and species. The natural diversity of scars includes rare cases, where damaged tissues regenerate without scarring. The scar\u002Fregeneration decision remains unresolved and scar prevention is a clinical challenge. Current research has been held up by",{"id":148,"funder":7,"programme":8,"title":149,"piName":10,"institution":150,"country":75,"year":13,"amount":55,"abstract":151},"cordis-european-research-council-award-817938","Synergistic engineering of anti-tumor immunity by synthetic biomaterials","UNIVERSITEIT GENT","Immunotherapy holds the potential to dramatically improve the curative prognosis of cancer patients. However, despite significant progress, a huge gap remains to be bridged to gain board success in the clinic. A first limiting factor in cancer immunotherapy is the low response rate in large fraction of the patients and an unmet need exists for more efficient - potentially synergistic - immunotherapies that improve upon or complement existing strategies. The second limiting factor is immune-relat",{"id":153,"funder":7,"programme":8,"title":154,"piName":10,"institution":155,"country":68,"year":13,"amount":156,"abstract":157},"cordis-european-research-council-award-819358","Utilizing Natural Dynamics for Reliable Legged Locomotion","TECHNISCHE UNIVERSITAET WIEN","€1,981,500","Despite the significant progress made in the field of humanoid robotics over the last 10-15 years, bipedal locomotion in robotics is still far from human performance in terms of speed, versatility, and robustness. The design of most humanoid robots nowadays is dominated by the aim at high rigidity and position accuracy in the motor units. In contrast, the NatDyReL project aims at a fundamental shift of paradigm in the design and control of humanoid robots, towards a new generation of intrinsical",{"id":159,"funder":7,"programme":8,"title":160,"piName":10,"institution":161,"country":125,"year":13,"amount":162,"abstract":163},"cordis-european-research-council-award-818751","Vibrating carbon nanotubes for probing quantum systems at the mesoscale","UNIVERSITY OF LANCASTER","€2,748,271","Many fascinating quantum behaviours occur on a scale that is intermediate between individual particles and large ensembles. It is on this mesoscopic scale that collective properties, including quantum decoherence, start to emerge.This project will use vibrating carbon nanotubes  like guitar strings just a micrometre long  as mechanical probes in this intermediate regime. Nanotubes are ideal to explore this region experimentally, because they can be isolated from thermal noise; they are deflected",{"id":165,"funder":7,"programme":8,"title":166,"piName":10,"institution":167,"country":132,"year":13,"amount":55,"abstract":168},"cordis-european-research-council-award-819698","Development of Thiophene Based Conjugated Polymers in Two Dimensions","TECHNISCHE UNIVERSITAET DRESDEN","The proceeding inexorable digitalisation of modern economics and society creates a steadily increasing demand on smart devices in the context of the industrial internet and the internet of things. To meet future requirements, organic electronics is a disruptive technology featuring low-cost, robust, lightweight, flexible and affordable devices based on organic small molecules and polymers. In contrast to the boosting development of linear conjugated polymers and their applications in organic ele",{"id":170,"funder":7,"programme":8,"title":171,"piName":10,"institution":172,"country":132,"year":13,"amount":173,"abstract":174},"cordis-european-research-council-award-816006","The Capillary Lock Actuator: A novel bistable microfluidic actuator for cost-effective high-density actuator arrays suitable for large-scale graphical tactile displays","ALBERT-LUDWIGS-UNIVERSITAET FREIBURG","€1,999,750","According to the World Health Organization more than 285 million people worldwide are visually impaired. In a world where graphics and online content (images, webpages) become increasingly important the inability to perceive information visually is the primary inhibitor for inclusion. In contrast to display technology for sighted people, tactile displays which translate text and graphics to touchable pixels (taxels) have seen little progress in recent decades. So-called Braille lines which displ",{"id":176,"funder":7,"programme":8,"title":177,"piName":10,"institution":178,"country":179,"year":13,"amount":180,"abstract":181},"cordis-european-research-council-award-818707","Sacralizing Security: Religion, Violence and Authority in Mega-Cities of the Global South","UNIVERSITEIT UTRECHT","NL","€1,975,234","In mega-cities of the Global South, state agencies often lack the capacity to provide infrastructure and security to all citizens. In such contexts, religious organizations and non-state security actors (vigilantes) have merged into alternative governance organizations.The emergence of religious vigilantes suggests a different connection between religion and violence than emphasized in current research on religious fundamentalism and terrorism. While religious vigilantes use violence systematica",{"id":183,"funder":7,"programme":8,"title":184,"piName":10,"institution":185,"country":186,"year":13,"amount":187,"abstract":188},"cordis-european-research-council-award-819819","Advanced Signal Processing Technologies for Wireless Powered Communications","UNIVERSITY OF CYPRUS","CY","€1,930,625","Wireless power transfer (WPT), pioneered by Tesla, is an idea at least as old as radio communications. However, on the one hand, due to health concerns and the large antenna dimensions required for transmission of high energy levels, until recently WPT has been limited mostly to very short distance applications. On the other hand, recent advances in silicon technology have significantly reduced the energy needs of electronic systems, making WPT over radio waves a potential source of energy for l",{"id":190,"funder":7,"programme":8,"title":191,"piName":10,"institution":192,"country":68,"year":13,"amount":10,"abstract":193},"cordis-european-research-council-award-816784","Globalized Memorial Museums. Exhibiting Atrocities in the Era of Claims for Moral Universals","OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN","The ‘universalization of the Holocaust’ has established the Shoah as an historical reference point legitimizing a global moral imperative to respect human rights. Much has been written about the ostensible ‘globalization of memory’, but as yet no genuinely global comparative study systematically confronting this hypothesis with the actual representations of atrocities exists. GMM breaks new ground by examining memorial museums on four continents, arguing that what is called ‘globalization’ in fa",{"id":195,"funder":7,"programme":8,"title":196,"piName":10,"institution":197,"country":75,"year":13,"amount":198,"abstract":199},"cordis-european-research-council-award-818702","A New Approach to the Evolution of Texts Based on the Manuscripts of the Targums","KATHOLIEKE UNIVERSITEIT LEUVEN","€1,966,259","TEXTEVOLVE will study the Targums. Targums are Jewish Aramaic paraphrases of the Hebrew Bible. They are important because they provide a unique insight into what Jews believed God was saying to them through their sacred texts at transformative moments in Jewish history, particularly the aftermath of the First Jewish-Roman War (66–74 CE). The state of the art in the study of the Targums is defined by 1) methodology, and 2) the primary sources that are available. TEXTEVOLVE will go beyond the stat",{"id":201,"funder":7,"programme":8,"title":202,"piName":10,"institution":203,"country":132,"year":13,"amount":204,"abstract":205},"cordis-european-research-council-award-819454","Understanding  Circumventing Antibiotic REsistance","EUROPEAN MOLECULAR BIOLOGY LABORATORY","€1,986,004","The evolution and spread of antibiotic resistance has become a public health concern of the utmost severity, making once treatable diseases deadly again and undermining our living standards. New therapies are imperative, but equally important are the understanding of the full repertoire of drivers of antibiotic resistance and the identification of ways to counteract them. We have recently established that ~250 non-antibiotic drugs have direct, strong and often broad antibacterial effects on huma",{"id":207,"funder":7,"programme":8,"title":208,"piName":10,"institution":209,"country":27,"year":13,"amount":55,"abstract":210},"cordis-european-research-council-award-818878","Developing CRISPR adaptation platforms for basic and applied research","TEL AVIV UNIVERSITY","The CRISPR-Cas system has been extensively studied for its ability to cleave DNA. In contrast, studies of the ability of the system to acquire and integrate new DNA from invaders as a form of prokaryotic adaptive immunity, have lagged behind. This delay reflects the extreme enthusiasm surrounding the potential of using the system’s cleavage capabilities as a genome editing tool. However, the enormous potential of the adaptation process can and should arouse a similar degree of enthusiasm. My lab",{"id":212,"funder":7,"programme":8,"title":213,"piName":10,"institution":214,"country":118,"year":13,"amount":215,"abstract":216},"cordis-european-research-council-award-817997","spontaneous Evolution and Clonal heterOgeneity in MoNoclonal Gammopathies: from mechanisms of progression to clinical management","UNIVERSITA DEGLI STUDI DI MILANO","€1,998,781","As an onco-hematologist with a strong expertise in genomics, I significantly contributed to the understanding of multiple myeloma (MM) heterogeneity and its evolution over time, driven by genotypic and phenotypic features carried by different subpopulations of cells. MM is preceded by prevalent, asymptomatic stages that may evolve with variable frequency, not accurately captured by current clinical prognostic scores. Supported by preliminary data, my hypothesis is that the same heterogeneity is ",{"id":218,"funder":7,"programme":8,"title":219,"piName":10,"institution":197,"country":75,"year":13,"amount":220,"abstract":221},"cordis-european-research-council-award-816638","The Aggregate Implications of Market Power","€1,575,000","It has been long understood by economists that market power can negatively affect welfare by limiting output, stifling innovation, and introducing inefficiencies in the overall allocation of production. On the one hand, there is ample evidence from case-studies, that the presence of market power, in the form of explicit or implicit cartels and other practices of anti-competitive behavior, can lead to substantial damages to producers and consumers in a given market. On the other hand, very little",{"id":223,"funder":7,"programme":8,"title":224,"piName":10,"institution":225,"country":48,"year":13,"amount":10,"abstract":226},"cordis-european-research-council-award-819192","Ice Age Genomic Tracking of Refugia and Postglacial Dispersal","UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET","Understanding rates of migration and resilience to climate change is important for explaining both the distribution of single species and anticipate how ecosystems may respond to climate change. There are two vigorously debated questions about the response of NW European biota to past climate changes: 1) glacial survival vs tabula rasa and 2) Reid´s paradox of rapid plant migration through seed dispersal vs. survival in cryptic refugia just south or east of the ice sheet. These are related as su",{"id":228,"funder":7,"programme":8,"title":229,"piName":10,"institution":209,"country":27,"year":13,"amount":230,"abstract":231},"cordis-european-research-council-award-817842","Pathogen-phage cooperation during mammalian infection","€2,200,000","Most bacterial pathogens are lysogens, namely carry DNA of active phages within their genome, referred to as prophages. While these prophages have the potential to turn under stress into infective viruses which kill their host bacterium in a matter of minutes, it is unclear how pathogens manage to survive this internal threat under the stresses imposed by their invasion into mammalian cells. In the proposed project, we will study the hypothesis that a complex bacteria-phage cooperative adaptatio",{"id":233,"funder":7,"programme":8,"title":234,"piName":10,"institution":235,"country":125,"year":13,"amount":236,"abstract":237},"cordis-european-research-council-award-817719","Mirror Mirror on the Wall, which Higgs is the oddest of them all: Exploring the Top-Higgs Interconnection with ATLAS","THE UNIVERSITY OF MANCHESTER","€1,999,998","With the ground-breaking discovery of a new scalar particle, the Higgs boson, in 2012 by ATLAS and CMS, the standard model (SM) of particle physics has been completed. Despite this success, many open questions on the fundamental laws of nature remain unanswered. Among these are how exactly particles acquire their mass and why there is more matter than antimatter in the universe.One of the most promising avenues to approach these questions is to explore the relation between the Higgs boson and th",{"id":239,"funder":7,"programme":8,"title":240,"piName":10,"institution":241,"country":242,"year":13,"amount":10,"abstract":243},"cordis-european-research-council-award-818665","Building up a Unified Theory of Stellar Dynamos","AALTO KORKEAKOULUSAATIO SR","FI","Magnetic fields are ubiquitous in the universe. The special property of cosmic magnetism is that, in the majority of objects hosting magnetic fields, those fields are organized, such that some meaningful averaging can reveal global structure and systematic behavior. In the Sun, averaging over longitude reveals the equatorward migration of the emergence region of the sunspots, forming the famous butterfly diagram. Further, vigorous turbulence is present in a wide variety of astrophysical systems,",{"id":245,"funder":7,"programme":8,"title":246,"piName":10,"institution":247,"country":132,"year":13,"amount":248,"abstract":249},"cordis-european-research-council-award-819025","The Consequences of the Internet for Russia's Informational Influence Abroad","UNIVERSITAT PASSAU","€1,999,535","Over the past decade, Russia’s ruling elites have massively stepped up their efforts to influ-ence media audiences abroad. Amongst others, Russia has been alleged to have sought to sway votes in Austria, France, Germany, Ukraine, and the US. This project’s overarching research ques-tion is: How, and with what consequences, have new Internet-based technologies contributed to the emergence of novel resources, techniques, and processes by which political elites in Moscow can influence media audienc",{"id":251,"funder":7,"programme":8,"title":252,"piName":10,"institution":253,"country":179,"year":13,"amount":254,"abstract":255},"cordis-european-research-council-award-817680","Homo Juridicus: Correcting Law's Behavioural Illiteracy","UNIVERSITEIT VAN AMSTERDAM","€1,999,405","Recent scientific research has revolutionised our understanding of how law can reduce misconduct. It shows that legal incentives are often flawed, and that strict punishment alone cannot deter misbehaviour. It offers a new approach for law to address wrongdoing, incorporating social norms and morals, tapping into unconscious cognition, and applying practical and technical interventions that obstruct misconduct. Yet, these fundamental insights continue to be ignored, and with every new disaster, ",{"id":257,"funder":7,"programme":8,"title":258,"piName":10,"institution":259,"country":125,"year":13,"amount":260,"abstract":261},"cordis-european-research-council-award-818045","Novel Lifesaving Magnetic Tentacles","UNIVERSITY OF LEEDS","€2,698,136","The aim of this project is to characterize fundamental principles at the intersection of robotics, magnetics, manufacturing and medicine, which will enable intelligent tentacle-like robots to augment the capabilities of surgeons in reaching deep into the human anatomy through complex winding pathways and treat inoperable diseases.Magnetic tentacle robots, proposed here for the first time, have the potential to be thin, extremely soft and scalable, and to conform to curvilinear trajectories by le",{"id":263,"funder":7,"programme":8,"title":264,"piName":10,"institution":265,"country":125,"year":13,"amount":266,"abstract":267},"cordis-european-research-council-award-818070","METABODY: Body Metacognition, Mentalization and Metamorphosis","UNIVERSITY COLLEGE LONDON","€1,989,376","We live in a socio-economic world that affords us with increasing options and technologies to control and present our bodily appearance to others, including by managing our eating habits, or by digital and even surgical body modification. These proliferating phenomena raise the age-old question of how we negotiate the balance between the invariance and invention of our identity. Addressing this question in relation to modern body image phenomena requires a radical new way of studying the concept",{"id":269,"funder":7,"programme":8,"title":270,"piName":10,"institution":271,"country":48,"year":13,"amount":272,"abstract":273},"cordis-european-research-council-award-819478","Cosmoglobe -- mapping the universe from the Milky Way to the Big Bang","UNIVERSITETET I OSLO","€1,999,382","In the aftermath of the high-precision Planck and BICEP2 experiments, cosmology has undergone a critical transition. Before 2014, most breakthroughs came as direct results of improved detector technology and increased noise sensitivity. After 2014, the main source of uncertainty will be due to astrophysical foregrounds, typically in the form of dust or synchrotron emission from the Milky Way. Indeed, this holds as true for the study of reionization and the cosmic dawn as it does for the hunt for",{"id":275,"funder":7,"programme":8,"title":276,"piName":10,"institution":138,"country":20,"year":13,"amount":277,"abstract":278},"cordis-european-research-council-award-818856","Higher coherent coholomogy of Shimura varieties","€1,288,750","One can attach certain complex analytic functions to algebraic varieties defined over the rational numbers, called Zeta functions. They are a vast generalization of Riemann’s zeta function. The Hasse-Weil conjecture predicts that these Zeta functions satisfy a functional equation and admit a meromorphic continuation to the whole complex plane. This follows from the conjectural Langlands program, which aims in particular at proving that Zeta functions of algebraic varieties are products of automo",{"id":280,"funder":7,"programme":8,"title":281,"piName":10,"institution":282,"country":283,"year":13,"amount":284,"abstract":285},"cordis-european-research-council-award-818615","Hybrid, organic-inorganic chalcogenide optoelectronics","NATIONAL CENTER FOR SCIENTIFIC RESEARCH DEMOKRITOS\"","EL","€2,731,250","The new generation of optoelectronics seeks for emerging semiconductors which combine high performance with low cost. Lead halide organic-inorganic perovskites manifest as excellent optoelectronic materials for this purpose, but at the expense of robustness and environmental compatibility. This presents a major challenge which this research addresses directly. Viable alternatives have to be identified. To tackle this challenge, MIX2FIX proposes to develop a new class of solution-processable opto",{"id":287,"funder":7,"programme":8,"title":288,"piName":10,"institution":289,"country":94,"year":13,"amount":290,"abstract":291},"cordis-european-research-council-award-819717","Transgenerational epigenetic inheritance of cardiac regenerative capacity in the zebrafish","UNIVERSITAET BERN","€1,999,125","While myocardial infarction leads to adverse ventricular remodeling ultimately causing heart failure in humans, some animals, including zebrafish can regenerate the injured heart. We recently revealed a high degree of plasticity in cardiomyocyte subpopulations involved in the reconstruction of the injured heart. The gene regulatory network involved in heart regeneration is starting to be elucidated and epigenetic remodeling has been suggested to play a pivotal role during this process. Similarly",{"id":293,"funder":7,"programme":8,"title":294,"piName":10,"institution":138,"country":20,"year":13,"amount":295,"abstract":296},"cordis-european-research-council-award-818521","Brain connections, Stroke, Symptoms Predictions and Brain Repair","€1,999,201","Every year a brain stroke will impair approximately 2 million Europeans. Notwithstanding recent progress, many of these individuals will have persistent cognitive deficits, impacting their personality, degrading their quality of life and preventing their return to work. Early identification of anatomical predictors of brain recovery may significantly reduce the burden of these deficits on patients, their families and wider society, while also leading to the discovery of new targets for treatment",{"id":298,"funder":7,"programme":8,"title":299,"piName":10,"institution":300,"country":20,"year":13,"amount":301,"abstract":302},"cordis-european-research-council-award-820048","3D integration of a logic\u002Fmemory CUBE for In-Memory-Computing","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","€2,734,139","For integrated circuits to be able to leverage the future “data deluge” coming from the cloud and cyber-physical systems, the historical scaling of Complementary-Metal-Oxide-Semiconductor (CMOS) devices is no longer the corner stone. At system-level, computing performance is now strongly power-limited and the main part of this power budget is consumed by data transfers between logic and memory circuit blocks in widespread Von-Neumann design architectures. An emerging computing paradigm solution ",{"id":304,"funder":7,"programme":8,"title":305,"piName":10,"institution":138,"country":20,"year":13,"amount":306,"abstract":307},"cordis-european-research-council-award-820033","Ultrasensitive Nano-Optomechanical Sensors","€2,067,905","By enabling the conversion of forces into measurable displacements, mechanical oscillators have always played a central role in experimental physics. Recent developments in the PI group demonstrated the possibility to realize ultrasensitive and vectorial force field sensing by using suspended SiC nanowires and optical readout of their transverse vibrations. Astonishing sensitivities were obtained at room and dilution temperatures, at the Atto- Zepto-newton level, for which the electron-electron ",{"id":309,"funder":7,"programme":8,"title":310,"piName":10,"institution":311,"country":41,"year":13,"amount":55,"abstract":312},"cordis-european-research-council-award-815357","Novel approaches to the generation of artificial spider silk superfibers","KAROLINSKA INSTITUTET","Spider silk is Nature’s high performance material that has the potential to revolutionize the materials industry. However, production and spinning of artificial spider silk fibers are challenging, and current methods to produce silk fibers include denaturing conditions which prevent the silk proteins from assembling into fibers in the same complex way as native silk proteins do. In order to fulfill the potential of spider silk we need to increase our understanding of the silk formation process a",{"id":314,"funder":7,"programme":8,"title":315,"piName":10,"institution":235,"country":125,"year":13,"amount":316,"abstract":317},"cordis-european-research-council-award-819417","Two-dimensional liquid cell dielectric microscopy","€1,998,829","Understanding molecular organization and dynamics which are governed by electrostatic and electrodynamics interactions on the nanoscale requires the measurement of dielectric polarization at the molecular level. Yet, this has remained a formidable challenge because standard dielectric spectroscopy is limited to the micrometer scale that is achieved by using microfabricated electrodes at low frequencies and optical approaches at high frequencies. At the same time, despite the advances in atomisti",{"id":319,"funder":7,"programme":8,"title":320,"piName":10,"institution":321,"country":48,"year":13,"amount":322,"abstract":323},"cordis-european-research-council-award-818449","A Genetic View into Past Sea Ice Variability in the Arctic","NORCE RESEARCH AS","€2,615,858","Arctic sea ice decline is the exponent of the rapidly transforming Arctic climate. The ensuing local and global implications can be understood by studying past climate transitions, yet few methods are available to examine past Arctic sea ice cover, severely restricting our understanding of sea ice in the climate system. The decline in Arctic sea ice cover is a ‘canary in the coalmine’ for the state of our climate, and if greenhouse gas emissions remain unchecked, summer sea ice loss may pass a c",{"id":325,"funder":7,"programme":8,"title":326,"piName":10,"institution":327,"country":125,"year":13,"amount":328,"abstract":329},"cordis-european-research-council-award-819458","Politics of Patents: Re-imagining citizenship via clothing inventions 1820 - 2020","GOLDSMITHS' COLLEGE","€1,802,154","From Victorian women cyclists, who suffered social stigma for daring to replace their skirts with bloomers a century ago, to the recent French burkini ban, where women were forcibly removed from beaches, specifically clothed bodies have long been sites of debate about gender, race, class and religion in public space. Clothing is directly connected to social life and the political world and as such is central to ideas around the politics of identity, participation and belonging. Yet, it is under ",{"id":331,"funder":7,"programme":8,"title":332,"piName":10,"institution":333,"country":125,"year":13,"amount":10,"abstract":334},"cordis-european-research-council-award-817577","The Cultural Logic of Honor and Social Interaction: A Cross-Cultural Comparison","THE UNIVERSITY OF SUSSEX","Understanding (un)willingness to coordinate with others, to compromise when faced with different choices, or to apologize for transgressions is crucial as these behaviors can act as strong facilitators or inhibitors of important interpersonal processes such as negotiations and coalition building. These behaviors play a major role when individuals from different cultural backgrounds work together to solve disputes or address joint challenges. Yet, we know little about what these behaviors mean in",{"id":336,"funder":7,"programme":8,"title":337,"piName":10,"institution":40,"country":41,"year":13,"amount":338,"abstract":339},"cordis-european-research-council-award-819374","Driven by mutualists: how declines in pollinators impact plant communities and ecosystem functioning","€1,998,842","Pollinator declines in response to land-use intensification have raised concern about the persistence of plant species dependent on insect pollination, in particular by bees, for their reproduction. Recent empirical studies show that reduced pollinator abundance decreases densities of seedlings of insect-pollinated plants and thereby changes the composition of grassland plant communities. Cascading effects on ecosystem functioning and associated organisms are expected, but to which extent and un",{"id":341,"funder":7,"programme":8,"title":342,"piName":10,"institution":343,"country":61,"year":13,"amount":344,"abstract":345},"cordis-european-research-council-award-819043","Rights and Egalitarianism","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","€1,319,355","REAL opens up new perspectives in moral and political philosophy by closing the rift between analytical theories of rights and egalitarian theories of distributive justice. There is a perception in both the academic and public discourse that pursuing egalitarian economic policies is incompatible with a commitment to rights. Socialist thinkers have traditionally been sceptical of rights, and contemporary egalitarian theories are often silent about them. At the same time, theories that take rights",{"id":347,"funder":7,"programme":8,"title":348,"piName":10,"institution":349,"country":125,"year":13,"amount":350,"abstract":351},"cordis-european-research-council-award-818085","Understanding the diversity of galaxy morphology in the era of large spectroscopic surveys","UNIVERSITY OF DURHAM","€1,741,230","Galaxies are the building blocks of structure in the Universe; this proposal seeks to understand how their shapes, colours and dynamics are determined. For example, what happened in the history of some galaxies to transform them into passive ellipticals while others, seemingly of the same mass and in the same environment, are star-forming spirals? Even such a basic question about the link between morphology and star formation has not yet been answered, revealing our theories of galaxy formation ",{"id":353,"funder":7,"programme":8,"title":354,"piName":10,"institution":355,"country":125,"year":13,"amount":356,"abstract":357},"cordis-european-research-council-award-818940","Initial Conditions of YMCs, Birth of OB associations and long term evolution of stellar clusters","THE UNIVERSITY OF EXETER","€1,980,385","The goal of this proposal is to establish a new era of stellar cluster evolution research by performing numerical simulations on different scales, and of different stages of a cluster’s life, from the formation of YMCs, the formation and evolution of OB associations, to the evolution of clusters and associations in galaxies. The PI is one of the pioneers of galactic simulations of GMC and star formation was one of the first numericists to perform galactic scale simulations of molecular cloud for",{"id":359,"funder":7,"programme":8,"title":360,"piName":10,"institution":300,"country":20,"year":13,"amount":10,"abstract":361},"cordis-european-research-council-award-818260","Renewable Hydride Donors and Their Utilization in Catalytic Reduction and Deoxygenation Reactions","The production of chemicals, plastics, solvents, etc., contributes to 20 % of the Gross Value Added in the EU, where sales have doubled over the last 20 years. Despite this dynamism, the chemical industry is energy intensive and 95 % of organic chemicals derive from fossil oil and natural gas. To sustain the growth of this industry, the replacement of fossil feedstocks with renewable carbon, phosphorus and silicon sources should be encouraged. Nonetheless, such a sourcing shift represents a para",{"id":363,"funder":7,"programme":8,"title":364,"piName":10,"institution":365,"country":75,"year":13,"amount":366,"abstract":367},"cordis-european-research-council-award-817940","PROTEIN TYROSINE PHOSPHATASES IN METABOLIC DISEASES: OXIDATION, DYSFUNCTION AND THERAPEUTIC POTENTIAL","UNIVERSITE LIBRE DE BRUXELLES","€1,966,906","Diabetes mellitus is characterised by hyperglycaemia caused by an absolute or relative insulin deficiency. The global prevalence of diabetes has reached more than 410 million individuals, underscoring the need for novel therapeutic strategies targeting the pathology as a multi-organ disease. Protein tyrosine phosphatases (PTPs) constitute a superfamily of enzymes that dephosphorylate tyrosine-phosphorylated proteins and oppose the actions of protein tyrosine kinases. My previous studies and prel",{"id":369,"funder":7,"programme":8,"title":370,"piName":10,"institution":371,"country":125,"year":13,"amount":10,"abstract":372},"cordis-european-research-council-award-817492","Searching for the Approximation Method used to Perform rationaL inference by INdividuals and Groups","UNIVERSITY OF WARWICK","Over the past two decades, a wave of Bayesian explanations has swept through cognitive science, explaining behaviour in domains from intuitive physics and causal learning, to perception, motor control and language. Yet people produce stunningly incorrect answers in response to even the simplest questions about probabilities. How can a supposedly Bayesian brain paradoxically reason so poorly with probabilities? Perhaps Bayesian brains do not represent or calculate probabilities at all and are, in",{"id":374,"funder":7,"programme":8,"title":375,"piName":10,"institution":376,"country":125,"year":13,"amount":377,"abstract":378},"cordis-european-research-council-award-818767","Sharing Gains from Trade: Global Markets and Farmers Welfare in Developing Countries","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","€1,996,009","The majority of the global poor live in rural areas and earn their livelihoods in agriculture. Linking farmers in developing countries (LDCs) to global markets, therefore, could potentially spur growth and reduce poverty. Market imperfections in agricultural chains in producing countries, however, limit these gains. Which policy tools, if any, help farmers in LDCs realize and share the gains from trade? I propose three broad projects that develop the tools to answer this question. The first proj",{"id":380,"funder":7,"programme":8,"title":381,"piName":10,"institution":382,"country":125,"year":13,"amount":383,"abstract":384},"cordis-european-research-council-award-819069","Additive manufacturing of 2D nanomaterials for on-chip technologies","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€1,999,968","The realization of “the internet of things” is inevitably constrained at the level of miniaturization that can be achieved in the electronic devices. A variety of technologies are now going through a process of miniaturization from micro-electromechanical systems (MEMS) to biomedical sensors, and actuators. The ultimate goal is to combine several components in an individual multifunctional platform, realizing on-chip technology. Devices have to be constrained to small footprints and exhibit high",{"id":386,"funder":7,"programme":8,"title":387,"piName":10,"institution":388,"country":94,"year":13,"amount":389,"abstract":390},"cordis-european-research-council-award-815962","Microbiota-host interactions for integrative metabolic health reprogramming","UNIVERSITE DE GENEVE","€1,999,999","Obesity is a metabolic disorder leading to various health risks and reduced life expectancy. Insulin resistance is a major obesity related disorder, and a main cause for the onset of type 2 diabetes. During cold exposure or caloric restriction (CR), brown adipocytes emerge within the white fat (known as “beige” cells). This process, referred to as fat browning, increases the metabolic capacity of the adipose tissues to combust energy and is seen as promising anti-obesity and anti-diabetic strate",{"id":392,"funder":7,"programme":8,"title":393,"piName":10,"institution":394,"country":118,"year":13,"amount":395,"abstract":396},"cordis-european-research-council-award-819627","Beyond Light Imaging: High-Rate Single-Photon Detection in Four Dimensions","ISTITUTO NAZIONALE DI FISICA NUCLEARE","€1,975,000","Goal of the 4DPHOTON project is the development and construction of a photon imaging detector with unprecedented performance. The proposed device will be capable of detecting fluxes of single-photons up to one billion photons per second, over areas of several square centimetres, and will measure - for each photon - position and time simultaneously with resolutions better than ten microns and few tens of picoseconds, respectively. These figures of merit will open many important applications allow",{"id":398,"funder":7,"programme":8,"title":399,"piName":10,"institution":400,"country":34,"year":13,"amount":401,"abstract":402},"cordis-european-research-council-award-819242","Targeting the adaptive capacity of prostate cancer through the manipulation of transcriptional and metabolic traits","ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS","€1,999,882","The composition and molecular features of tumours vary during the course of the disease, and the selection pressure imposed by the environment is a central component in this process. Evolutionary principles have been exploited to explain the genomic aberrations in cancer. However, the phenotypic changes underlying disease progression remain poorly understood. In the past years, I have contributed to identify and characterise the therapeutic implications underlying metabolic alterations that are ",{"id":404,"funder":7,"programme":8,"title":405,"piName":10,"institution":26,"country":27,"year":13,"amount":55,"abstract":406},"cordis-european-research-council-award-818086","The tumor microbial communities: Characterization, effects and translational opportunities","The human body is host to a huge number of bacteria. While bacteria were first detected in human tumors over 150 years ago, our knowledge about their number, identity or effects in different human tumor types is still mostly rudimentary.Over the last few years we focused on studying the tumor microbiome. We developed multiple methods to characterize and visualize intra-tumor bacteria, taking special measures to tell apart true tumor-bacteria from contamination. Profiling over 1,800 human tumors ",{"id":408,"funder":7,"programme":8,"title":409,"piName":10,"institution":271,"country":48,"year":13,"amount":410,"abstract":411},"cordis-european-research-council-award-818425","Socioeconomic gaps in language development and school achievement: Mechanisms of inequality and opportunity","€1,907,959","As inequality increases in most developed countries, children from socioeconomically disadvantaged families are at exceptional risk for academic underachievement with lasting consequences for individuals, their communities, and society at large. Among policy makes, early childhood education and care (ECEC) is considered a key to remedy this risk. Yet the science on ECEC effectiveness at a national scale lags behind the excitement.Exploiting unique Norwegian data, we first seek to identify how an",{"id":413,"funder":7,"programme":8,"title":414,"piName":10,"institution":33,"country":34,"year":13,"amount":415,"abstract":416},"cordis-european-research-council-award-817959","Religion and Its Others in South Asia and the World: Communities, Debates, Freedoms","€1,999,782","Those who question or do not conform to dominant local religious tradition(s) and\u002For religion as such have, of course, faced serious problems and difficulties in a number of different historical periods and locations. This project examines the forms in which individuals and communities raise, in the open or in more hidden transcripts, questions over the dominant religious norms in South Asia. This project is also interested in how such people are being targeted as distinct minorities by various ",{"id":418,"funder":7,"programme":8,"title":419,"piName":10,"institution":420,"country":68,"year":13,"amount":421,"abstract":422},"cordis-european-research-council-award-820008","Dissipative self-assembly in synthetic systems: Towards life-like materials","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","€1,999,572","Living organisms are sophisticated self-assembled structures that exist and operate far from thermodynamic equilibrium and, as such, represent the ultimate example of dissipative self-assembly. They remain stable at highly organized (low-entropy) states owing to the continuous consumption of energy stored in chemical fuels, which they convert into low-energy waste. Dissipative self-assembly is ubiquitous in nature, where it gives rise to complex structures and properties such as self-healing, ho",{"id":424,"funder":7,"programme":8,"title":425,"piName":10,"institution":426,"country":118,"year":13,"amount":427,"abstract":428},"cordis-european-research-council-award-819815","Dissecting and Overcoming Innate Immune Barriers for Therapeutically Efficient Hematopoietic Stem Cell Gene Engineering","UNIVERSITA DEGLI STUDI DI PAVIA","€1,994,375","The low gene manipulation efficiency of human hematopoietic stem cells (HSC) remains a major hurdle for sustainable and broad clinical application of innovative therapies for a wide range of disorders. Indeed, high vector doses and prolonged ex vivo culture are still required for clinically relevant levels of gene transfer even with the most established lentiviral vector-based delivery platforms. Current and emerging gene transfer and editing technologies expose HSC to components potentially rec",{"id":430,"funder":7,"programme":8,"title":431,"piName":10,"institution":93,"country":94,"year":13,"amount":432,"abstract":433},"cordis-european-research-council-award-819573","Advancing CO2 Capture Materials by Atomic Scale Design: the Quest for Understanding","€1,994,900","Carbon dioxide capture and storage is a technology to mitigate climate change by removing CO2 from flue gas streams or the atmosphere and storing it in geological formations. While CO2 removal from natural gas by amine scrubbing is implemented on the large scale, the cost of such process is currently prohibitively expensive. Inexpensive alkali earth metal oxides (MgO and CaO) feature high theoretical CO2 uptakes, but suffer from poor cyclic stability and slow kinetics. Yet, the key objective of ",{"id":435,"funder":7,"programme":8,"title":436,"piName":10,"institution":437,"country":125,"year":13,"amount":438,"abstract":439},"cordis-european-research-council-award-818457","Project Fortitude: Improving children's legal capability","THE UNIVERSITY OF SHEFFIELD","€1,999,935","The aim of this project is to improve the legal capability of children. This focus on children breaks new ground because other research into legal capability focuses on adults. On paper, children are both empowered and protected by numerous laws and international rights instruments. In practice, however, we know that millions of children live at risk of violence, abuse and neglect in the UK alone. The proposed research seeks to create a range of resources that will empower and enable children wh",{"id":441,"funder":7,"programme":8,"title":442,"piName":10,"institution":443,"country":132,"year":13,"amount":444,"abstract":445},"cordis-european-research-council-award-815378","Macro- and Microeconomic Analyses of Heterogeneous Labor Market Outcomes","JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN","€1,597,950","This proposal analyzes labor markets from both a macro- and a microeconomic perspective. It consists of four subprojects with the common objective to significantly advance our understanding of heterogeneities in labor market behavior and outcomes. The subprojects lead to novel insights regarding the intended and unintended consequences of different public policies, ranging from educational policies over the welfare state to maternal leave policies. The starting point of the first subproject are ",{"id":447,"funder":7,"programme":8,"title":448,"piName":10,"institution":449,"country":132,"year":13,"amount":450,"abstract":451},"cordis-european-research-council-award-819317","Certified Quantum Security","RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN","€1,716,475","Digital communication permeates all areas of today's daily life. Cryptographic protocols are used to secure thatcommunication. Quantum communication and the advent of quantum computers both threaten existing cryptographicsolutions, and create new opportunities for secure protocols. The security of cryptographic systems is normally ensured bymathematical proofs. Due to human error, however, these proofs often contain errors, limiting the usefulness of said proofs.This is especially true in the ca",{"id":453,"funder":7,"programme":8,"title":454,"piName":10,"institution":259,"country":125,"year":13,"amount":455,"abstract":456},"cordis-european-research-council-award-818633","GRoup thinking: new fOUNDationS","€1,997,959","This project builds new foundations for collective attitudes and representational states: group belief and group desire. Theplatform is the PI’s recent advances in the metaphysics of representation for individual representational states, where hedevelops and defends a substantive, realist interpretationism: (i) what it is to believe\u002Fdesire that p is for the selectedinterpretation to attribute that belief\u002Fdesire to them; (ii) the selected interpretation is that which makes the subject mostreason-",{"id":458,"funder":7,"programme":8,"title":459,"piName":10,"institution":460,"country":34,"year":13,"amount":55,"abstract":461},"cordis-european-research-council-award-818299","Subsistence and human resilience to sudden climatic events in Europe during MIS3","UNIVERSIDAD DE CANTABRIA","Climate has long been proposed as a possible trigger-factor for the extinction of Neanderthals and the rapid colonization of Europe by Anatomically Modern Humans (AMH). Abrupt and acute oscillations of climate, as recorded from polar ice sheets, are particularly threatening as they can push ecosystems towards catastrophic outcomes. Under these conditions, the survival of a species critically depends on their adaptive skills. Understanding the exact role that these episodes could have had in the ",{"id":463,"funder":7,"programme":8,"title":464,"piName":10,"institution":465,"country":132,"year":13,"amount":466,"abstract":467},"cordis-european-research-council-award-818846","Identifying spatial determinants of immune cell fate commitment","JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG","€1,997,500","The complex architecture of the mammalian hematopoietic system has been studied for decades, yet the molecular mechanisms underlying cell fate commitment remain poorly understood. Although cytokine signals are major determinants of hematopoietic cell fate, only few niches of stem and progenitor cells have been characterized. Here, we propose to resolve the cell type composition of mouse bone marrow by integrating single-cell RNA-seq with high-resolution spatial analysis of gene expression in tis",{"id":469,"funder":7,"programme":8,"title":470,"piName":10,"institution":265,"country":125,"year":13,"amount":471,"abstract":472},"cordis-european-research-council-award-818992","Wage inequality within and across firms: The role of market forces, government and firm policies","€1,491,803","Wage inequality in industrialised countries has increased sharply over the past decades, and much of this increase has occurred between rather than within firms. Furthermore, substantial inequality between men and women persists in all industrialised countries, and a large part of the gender gaps observed today is attributable to the arrival of children. In this proposal, we put firms at the centre of the analysis and ask the following questions: First, which market forces can (partly) explain t",{"id":474,"funder":7,"programme":8,"title":475,"piName":10,"institution":476,"country":34,"year":13,"amount":477,"abstract":478},"cordis-european-research-council-award-817911","Long-term coastal adaptation, food security and poverty alleviation in Latin America","UNIVERSITAT AUTONOMA DE BARCELONA","€1,877,107","TRADITION aims to understand the long-term trajectory of human interaction with coastal resources and its legacy to present day small-scale fisheries in Latin America. Founded on traditional knowledge rooted in the past, small-scale fisheries are a crucial source of food and livelihood for millions of people worldwide, and play a pivotal role in poverty eradication in developing countries. A thorough recognition of the cultural and socio-economic significance of Latin American fisheries requires",{"id":480,"funder":7,"programme":8,"title":481,"piName":10,"institution":26,"country":27,"year":13,"amount":55,"abstract":482},"cordis-european-research-council-award-819439","Decoding interactions between adipose tissue immune cells, metabolic function, and the intestinal microbiome in obesity","Obesity and its metabolic co-morbidities have given rise to a rapidly expanding ‘metabolic syndrome’ pandemic affectinghundreds of millions of individuals worldwide. The integrative genetic and environmental causes of the obesity pandemicremain elusive. White adipose tissue (WAT)-resident immune cells have recently been highlighted as important factorscontributing to metabolic complications. However, a comprehensive understanding of the regulatory circuits governing theirfunction and the cell ty",{"id":484,"funder":7,"programme":8,"title":485,"piName":10,"institution":465,"country":132,"year":13,"amount":486,"abstract":487},"cordis-european-research-council-award-819329","Spatiotemporal regulation of T-cell Priming","€1,874,425","The initiation of adaptive cellular immunity requires antigen-specific interactions between Dendritic cells (DC) and naive CD8 T cells in secondary lymphoid organs. We aim to understand how the dynamic migratory behavior of myeloid and lymphoid cells is coordinated to ensure that “the right cells” communicate at “the right time” in “the right place” to enable robust immune responses. Using intravital microscopy, we have recently identified a critical phase (“Step 2”) of T cell priming that follo",{"id":489,"funder":7,"programme":8,"title":490,"piName":10,"institution":253,"country":179,"year":13,"amount":55,"abstract":491},"cordis-european-research-council-award-819455","Distributed dynamic REpresentations for diAlogue Management","Our ability to communicate using language in conversation is considered the hallmark of human intelligence. Yet, while holding a dialogue is effortless for most of us, modelling this basic human skill by computational means has proven extremely difficult. In DREAM, I address this challenge by establishing a new computational model of a dialogue agent that can learn to take part in conversation directly from data about language use. DREAM stands at the crossroads of the symbolic and the sub-symbo",{"id":493,"funder":7,"programme":8,"title":494,"piName":10,"institution":138,"country":20,"year":13,"amount":495,"abstract":496},"cordis-european-research-council-award-817493","Ice CORe DAting tools revisited to infer the dynamic of glacial – interglacial transitions over the last 1.5 million years","€1,994,100","The Quaternary period (last 2600 thousands of years, hereafter ka) is the ideal period to evaluate our understanding of climate processes with general circulation models (GCM) used for prediction of future climate. During this period, the largest climate changes are glacial – interglacial transitions, hereafter terminations, the last termination being a classical benchmark for GCM. The rhythm of terminations changed from a world associated with a 40 ka periodicity to a world associated with a 10",{"id":498,"funder":7,"programme":8,"title":499,"piName":10,"institution":500,"country":118,"year":13,"amount":501,"abstract":502},"cordis-european-research-council-award-815673","GRavity from Astrophysical to Microscopic Scales","SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE","€1,993,920","General Relativity (GR) describes gravity on a huge range of scales, field strengths and velocities. However, despite its successes, GR has been showing its age. Cosmological data support the existence of a Dark Sector, but may also be interpreted as a breakdown of our understanding of gravity. Also, GR is intrinsically incompatible with quantum field theory, and should be replaced, at high energies, by a (still unknown) quantum theory of gravity.This deadlock may prelude to a paradigm change in",{"id":504,"funder":7,"programme":8,"title":505,"piName":10,"institution":26,"country":27,"year":13,"amount":506,"abstract":507},"cordis-european-research-council-award-815869","Nonlinear Optical and Electrical Phenomena in Topological Semimetals","€1,721,706","In the past decade, the band-structure topology and related topological materials have been intensively studied mostly by revealing their unique surface states. The current proposal sets a new paradigm by focusing on nonlinear optical phenomena in topological semimetals (TSMs). I aim to investigate the photocurrent and second-harmonic generation, as well as to discover novel nonlinear effects. The strength of TSMs lies in the fact that the giant Berry curvature in their band-crossing regions (e.",{"id":509,"funder":7,"programme":8,"title":510,"piName":10,"institution":511,"country":125,"year":13,"amount":512,"abstract":513},"cordis-european-research-council-award-817597","Interactions between Groups, Orbits, and Cartans","UNIVERSITY OF GLASGOW","€1,296,966","Recently, we discovered that the notion of Cartan subalgebras builds bridges between C*-algebras, topological dynamics, and geometric group theory. The goal of this research project is to develop our understanding of this concept in order to attack the following major open questions:I. The UCT questionII. The Baum-Connes conjectureIII. The conjugacy problem for topological shiftsIV. Quasi-isometry rigidity for polycyclic groupsUCT stands for Universal Coefficient Theorem and is a crucial ingredi",{"id":515,"funder":7,"programme":8,"title":516,"piName":10,"institution":93,"country":94,"year":13,"amount":517,"abstract":518},"cordis-european-research-council-award-818195","Trapped-ion quantum information in 2-dimensional Penning trap arrays","€1,999,375","This project will develop a new platform for quantum computation and quantum simulation based on scalable two-dimensional arrays of ions in micro-fabricated Penning traps. It builds upon the rapid advances demonstrating high precision quantum control in micro-fabricated radio-frequency ion traps while eliminating the most problematic element - the radio-frequency potential - using a uniform magnetic field. This offers a significant advantage: since the magnetic field is uniform it provides confi",{"id":520,"funder":7,"programme":8,"title":521,"piName":10,"institution":522,"country":20,"year":13,"amount":523,"abstract":524},"cordis-european-research-council-award-814747","Site-specific Ultrasensitive Magnetic resonance of Mixtures for Isotopic Tracking","NANTES UNIVERSITE","€1,999,768","There is a high demand to design approaches capable of tracking the origin of biomarkers in complex biological environments, in the areas of life, environmental, food and forensic sciences. Metabolomics and Fluxomics show great promises towards this aim, and a high potential arises from their combination with Isotopic fingerprinting at natural abundance. The resulting isotopomics approach requires cutting-edge analytical tools, and Nuclear Magnetic Resonance (NMR) is currently the only generic t",{"id":526,"funder":7,"programme":8,"title":527,"piName":10,"institution":528,"country":179,"year":13,"amount":55,"abstract":529},"cordis-european-research-council-award-817533","Post-transcriptional regulation of effector function in T cells by RNA binding proteins","Stichting Sanquin Bloedvoorziening","CD8+ T cells are critical to fight infections and to clear tumor cells through the production of inflammatory cytokines and cytotoxic molecules. These effector molecules must be tightly controlled: too little leads to the inability to control the pathogen, and too much can result in a life-threatening cytokine storm and tissue damage. While transcriptional control of effector genes is well-studied, regulation at the levels of RNA stability and translation efficiency by RNA-binding proteins (RBPs",{"id":531,"funder":7,"programme":8,"title":532,"piName":10,"institution":138,"country":20,"year":13,"amount":533,"abstract":534},"cordis-european-research-council-award-819511","Novel assembly strategies in liquid dispersion via interface control – towards cellular metamaterials","€1,999,677","The astounding properties of metamaterials result from a characteristic spatial organisation of purpose-designed structural units. Research on metamaterials has greatly advanced thanks to their reliable top-down fabrication (lithography, 3D-printing,...). For large-scale production, however, smart bottom-up design strategies are required, for example through self-assembly of the structural units. While this has been developed for thermally-driven systems with sub-micrometric units, no systematic",{"id":536,"funder":7,"programme":8,"title":537,"piName":10,"institution":538,"country":132,"year":13,"amount":539,"abstract":540},"cordis-european-research-council-award-819892","Law without Mercy: Japanese Courts-Martial and Military Courts During the Asia-Pacific War, 1937-45","FREIE UNIVERSITAET BERLIN","€1,697,776","Japan fought the war over East and Southeast Asia between 1937 and 1945 not only in the theatres of war, but with equal harshness in the courtrooms of military justice. Wherever Japanese soldiers went, judge-advocates followed, meeting out stern justice to soldiers, civilians and enemy soldiers alike. The system of courts-martial and military courts throughout East and Southeast Asia served three purposes: regulate violence and channel it efficiently to serve Japan's war goals; deter the civilia",{"id":542,"funder":7,"programme":8,"title":543,"piName":10,"institution":544,"country":68,"year":13,"amount":545,"abstract":546},"cordis-european-research-council-award-818772","Possible Life: The Philosophical Significance of Extending Biology","UNIVERSITAT WIEN","€1,999,566","Possible Life: The Philosophical Significance of Extending BiologyDue to the latest technological advances in genetic engineering and space technology, scientists have developed strategies to engineer novel biological systems in laboratories, and to study through space telescopes the signs of possible life from other planets and solar systems. These newly discovered biological possibilities may turn out to be epoch-making. Apart from challenging our notion of life, they also have fundamental phi",{"id":548,"funder":7,"programme":8,"title":549,"piName":10,"institution":550,"country":68,"year":13,"amount":551,"abstract":552},"cordis-european-research-council-award-817615","Tailoring Microstructure and Architecture to Build Ceramic Components with Unprecedented Damage Tolerance","MONTANUNIVERSITAET LEOBEN","€1,985,000","Advanced ceramics are often combined with metals, polymers or other ceramics to produce structural and functional systems with exceptional properties. Examples are resistors and capacitors in microelectronics, piezo-ceramic actuators in car injection devices, and bio-implants for hip joint replacements. However, a critical issue affecting the functionality, lifetime and reliability of such systems is the initiation and uncontrolled propagation of cracks in the brittle ceramic parts, yielding in ",{"id":554,"funder":7,"programme":8,"title":555,"piName":10,"institution":178,"country":179,"year":13,"amount":55,"abstract":556},"cordis-european-research-council-award-819566","Project on Integrated Assessment model-based Scenarios for Sustainable development Objectives","In 2015, nearly all nations agreed on a set of ambitious Sustainable Development Goals (SDGs) to ensure environment protection and human development. Accounting for the coherence of the overall set of goals presents a major scientific challenge as there are many complex relationships and feedbacks between them and across various scales (local to global, near- and long-term). However, in fact very little scientific information exists on how to achieve such a diverse set of goals simultaneously. I",{"id":558,"funder":7,"programme":8,"title":559,"piName":10,"institution":560,"country":179,"year":13,"amount":55,"abstract":561},"cordis-european-research-council-award-817947","Field Control of Cold Molecular Collisions","STICHTING RADBOUD UNIVERSITEIT","It is a long held dream of chemical physicists to study (and to control!) the interactions between individual molecules in completely specified collisions. This project brings this goal within reach. I will develop novel methods to study collisions between individual molecules at temperatures between 10 mK and 10 K, and to manipulate their interaction using electric and magnetic fields. Under these cold conditions, the collisions are dominated by quantum effects such as interference and tunnelin",{"id":563,"funder":7,"programme":8,"title":564,"piName":10,"institution":349,"country":125,"year":13,"amount":10,"abstract":565},"cordis-european-research-council-award-820185","Perception with New Sensory Signals","Advances in wearable displays and networked devices lead to the exciting possibility that humans can transcend the senses they were born with and learn to ‘see’ the world in radically new ways. Genuinely incorporating new signals in our sensory repertoire would transform our everyday experience, from social encounters to surgery, and advance us towards a technologically-enhanced ‘transhuman’ state. In contrast, current additions to sensory streams such as navigating with GPS are far from being i",{"id":567,"funder":7,"programme":8,"title":568,"piName":10,"institution":569,"country":242,"year":13,"amount":570,"abstract":571},"cordis-european-research-council-award-818437","Quantitative stochastic homogenization of variational problems","HELSINGIN YLIOPISTO","€1,312,500","The proposal addresses various multiscale problems which lie at the intersection of probability theory and the analysis of partial differential equations and calculus of variations. Most of the proposed problems fit under the framework of stochastic homogenization, that is, the study of large-scale statistical properties of solutions to equations with random coefficients. In the last ten years, there has been significant progress made in developing a quantitative theory of stochastic homogenizat",{"id":573,"funder":7,"programme":8,"title":574,"piName":10,"institution":124,"country":125,"year":13,"amount":575,"abstract":576},"cordis-european-research-council-award-819956","Pathogenesis and treatment of splicing factor mutant myelodysplastic syndromes","€1,999,771","The myelodysplastic syndromes (MDS) are a heterogeneous group of malignancies of the haematopoietic stem cell (HSC) with a tendency for leukaemic transformation. Despite some new therapies, the MDS are lethal to most sufferers and in need of new effective treatments. Splicing factor gene mutations are the commonest class of somatic alterations in MDS and primarily affect the genes SF3B1, SRSF2, U2AF1 and ZRSR2. The mutations are associated with altered mRNA splicing, but each affects different t",{"id":578,"funder":7,"programme":8,"title":579,"piName":10,"institution":580,"country":125,"year":13,"amount":581,"abstract":582},"cordis-european-research-council-award-819593","Imaging Biomolecular Self-Assembly with a Molecular Photonic Scale","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€1,999,574","We propose to transform our understanding of biomolecular interactions and self-assembly by directly visualising the associated molecular mechanisms. To achieve this, we will capitalise on our recent development of interferometric scattering mass spectrometry (iSCAMS), which enables not only the detection and imaging of single biomolecules in solution, but also the accurate determination of their molecular mass at the single molecule level. These studies, and the development of the associated te",{"id":584,"funder":7,"programme":8,"title":585,"piName":10,"institution":586,"country":179,"year":13,"amount":55,"abstract":587},"cordis-european-research-council-award-819424","Flow and Deformation of Cancer tumours near Yielding","TECHNISCHE UNIVERSITEIT DELFT","The aim of this proposal is to understand when, how and why metastatic tumour cells detach from a tumour. Often, primary tumours do not kill patients, but secondary tumours do. These so-called metastatic tumour cells disassociate from a primary tumour and, ultimately, prove fatal. Currently, we do not understand the fundamentals of the biophysical pathways and mechanisms of the metastasis of cancer, hampering medical intervention. I propose a multidisciplinary approach, combining engineering, ch",{"id":589,"funder":7,"programme":8,"title":590,"piName":10,"institution":289,"country":94,"year":13,"amount":591,"abstract":592},"cordis-european-research-council-award-817919","Unifying the three pillars of Geodesy using space ties","€1,999,563","Terrestrial Reference Frames (TRFs) are the basis to which all positions on the Earth’s surface and all satellite orbits in the near Earth space have to refer to. The changes in the Earth's shape, rotation, and gravity field, the so-called three pillars of geodesy, provide the conceptual and observational basis for the TRFs. For today’s TRF realizations, four space geodetic techniques are combined and linked by co-location sites on the Earth’s surface (“Earth’s shape”) and by common Earth orient",{"id":594,"funder":7,"programme":8,"title":595,"piName":10,"institution":596,"country":132,"year":13,"amount":597,"abstract":598},"cordis-european-research-council-award-816564","Action selection under threat: the complex control of human defense","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","€1,998,750","Run away, sidestep, duck-and-cover, watch: when under threat, humans immediately choreograph a large repertoire of defensive actions. Understanding action-selection under threat is important for anybody wanting to explain why anxiety disorders imply some of these behaviours in harmless situations. Current concepts of human defensive behaviour are largely derived from rodent research and focus on a small number of broad, cross-species, action tendencies. This is likely to underestimate the comple",{"id":600,"funder":7,"programme":8,"title":601,"piName":10,"institution":580,"country":125,"year":13,"amount":602,"abstract":603},"cordis-european-research-council-award-819953","Linking the Textual Worlds of Chinese Court Theater, ca. 1600-1800","€1,991,777","Court theater was a core part of Chinese court and performance culture for centuries, yet its texts have never been amply studied. There are several reasons for this: their low status in Chinese literary history as ‘authorless’ performer’s texts; the vast (20,000+) quantity of texts and the difficulty of accessing them; and the lack of an existing analytic framework to study anonymous Chinese performance texts on such a large scale. Chinese court drama thus remains a ‘closed’ textual world, negl",{"id":605,"funder":7,"programme":8,"title":606,"piName":10,"institution":580,"country":125,"year":13,"amount":607,"abstract":608},"cordis-european-research-council-award-819086","High-Dimensional Inference for Panel and Network Data","€1,478,831","Improved data availability in Economics provides access to richer datasets with increased complexity. There is regularly a network aspect to the data, whenever outcomes are observed for matches of different economic units (e.g. households, individuals, firms, products, markets). Such observations include, e.g., wages for workers in firms, academic achievement for students taught by teachers in schools, and purchasing decisions for consumers in stores. The underlying network structure is often sp",{"id":610,"funder":7,"programme":8,"title":611,"piName":10,"institution":382,"country":125,"year":13,"amount":612,"abstract":613},"cordis-european-research-council-award-819141","Program Analysis for Safe and Secure Software Evolution","€1,955,129","Constant evolution is an inherent property of modern software systems. Software evolves to implement new features, adapt to new hardware and platforms, fix bugs and security vulnerabilities, or improve non-functional properties such as performance and energy consumption.While these changes have an overall positive impact, they are also responsible for a large number of critical bugs and security attacks. The reason is twofold: first, software changes are not vetted enough, due to the difficulty ",{"id":615,"funder":7,"programme":8,"title":616,"piName":10,"institution":569,"country":242,"year":13,"amount":617,"abstract":618},"cordis-european-research-council-award-818930","Post-Newtonian modelling of the dynamics of supermassive black holes in galactic-scale hydrodynamical simulations (KETJU)","€1,953,569","Supermassive black holes (SMBHs) with masses in the range ~10^6-10^10 M⊙ are found at the centres of all massive galaxies in the Local Universe. In the ΛCDM picture of structure formation galaxies grow bottom-up through mergers and gas accretion, leading to multiple SMBHs in the same stellar system. Current simulation codes are unable to resolve in a single simulation the full SMBH merging process, which involves dynamical friction, three-body interactions and finally gravitational wave (GW) emi",{"id":620,"funder":7,"programme":8,"title":621,"piName":10,"institution":622,"country":20,"year":13,"amount":623,"abstract":624},"cordis-european-research-council-award-817803","Passive seismic scanning of the preparation phase of damaging earthquakes","UNIVERSITE GRENOBLE ALPES","€2,524,630","The recent September 2017, magnitude 7.1, central Mexico earthquake that caused 370 casualties reminds us that earthquakes are among the most dramatic natural disasters worldwide. Causal physical processes are not instantaneous and laboratory and numerical experiments predict that earthquakes should be preceded by a detectable slow preparation phase. Despite considerable efforts, however, robust geophysical precursors have not yet been observed before damaging earthquakes. My FaultScan project w",{"id":626,"funder":7,"programme":8,"title":627,"piName":10,"institution":560,"country":179,"year":13,"amount":628,"abstract":629},"cordis-european-research-council-award-818399","Creating complexity: toward atomic spin-based neural hardware","€2,357,390","The growing trend in global electricity consumption has created a new challenge for materials-based science: to find computational paradigms toward ICT that are not only smaller and faster, but also energy-efficient. A new source of inspiration is the human brain, which consumes a mere 20 W of energy, while a supercomputer consumes about 10 MW. The emerging field of brain-inspired hardware aims at utilizing physical phenomena in high-quality materials toward pattern recognition and energy- effic",{"id":631,"funder":7,"programme":8,"title":632,"piName":10,"institution":209,"country":27,"year":13,"amount":633,"abstract":634},"cordis-european-research-council-award-818899","Relativistic Jets in Astrophysics - Compact binary mergers, Gamma-Ray Bursts, and Beyond","€1,981,250","What is the origin of the electromagnetic (EM) counterparts of gravitational waves observed from compact binary mergers? What makes short gamma ray bursts (GRBs)? What are the sources of IceCube’s high-energy neutrinos? Are all core-collapse supernovae exploding via the same mechanism? These are some of the puzzles that have emerged with the rapid progress of time domain astronomy. Relativistic jets in compact binary mergers and GRBs, and their interaction with the surrounding media hold the key",{"id":636,"funder":7,"programme":8,"title":637,"piName":10,"institution":638,"country":125,"year":13,"amount":639,"abstract":640},"cordis-european-research-council-award-819213","Enacting border security in the digital age: political worlds of data forms, flows and frictions.","KING'S COLLEGE LONDON","€1,897,826","Datafication, the process transforming our everyday lives into quantifiable digital data, is also transforming borders today. Data collection, exchange and interoperability have become key for EU border security. How does data enact border security in the digital age? What are the political and ethical implications of these processes of datafication? This project proposes to develop a novel interdisciplinary framework to understand how data is generated, exchanged and contested in border encount",{"id":642,"funder":7,"programme":8,"title":643,"piName":10,"institution":420,"country":68,"year":13,"amount":644,"abstract":645},"cordis-european-research-council-award-819603","Learning the shape of synaptic plasticity rules for neuronal architectures and function through machine learning.","€1,798,605","How do we learn to dance, play an instrument, or a game as complex as chess or go? How do we make a memory? The common answer to these questions is “through synaptic plasticity”, through changing the synaptic connectivity of neural circuits so that representative brain activity can be reliably triggered. Such connectivity changes are governed by rules, i.e., synaptic mechanisms which monitor the activity of their environment and stereotypically strengthen or weaken synapses accordingly. The shap",{"id":647,"funder":7,"programme":8,"title":648,"piName":10,"institution":209,"country":27,"year":13,"amount":55,"abstract":649},"cordis-european-research-council-award-819151","The Neuronal Code of Inheritance","Little is known about non-DNA mediated transgenerational inheritance of parental responses. If inheritance of non-genetic materials is prevalent, it could challenge our conceptions regarding the rules and limits of heredity. We are in particularly intrigued by the possibility that the nervous system can produce heritable changes. Mechanisms for propagation of responses from the soma to the germline are known. Until very recently, the possibility that any type of environmental response could beco",{"id":651,"funder":7,"programme":8,"title":652,"piName":10,"institution":653,"country":12,"year":13,"amount":654,"abstract":655},"cordis-european-research-council-award-818761","Efficient Conversion of Quantum Information Resources","KOBENHAVNS UNIVERSITET","€1,953,750","This proposal explores the power of quantum information in two respects. The first is the technological power of quantum information in a communication infrastructure, and the second is its descriptive power in many-particle quantum systems. My point of departure is to view quantum information as a resource that can be processed and converted.In quantum communication, a famous resource conversion is provided by the quantum teleportation protocol, which allows us to send one quantum bit (1 qubit)",{"id":657,"funder":7,"programme":8,"title":658,"piName":10,"institution":93,"country":94,"year":13,"amount":659,"abstract":660},"cordis-european-research-council-award-819740","Multiscale chemical engineering of functional metal halides","€1,999,950","SCALE-HALO proposes a research program that will advance the development of highly luminescent molecular and solid-state compounds by focusing on the emerging, vast, and rather underexplored compositional and structural spaces comprised of metals and halogens, i.e., metal halides (MHs). SCALE-HALO is motivated by the eventual utility of MHs as versatile photonic sources in modern appliances (e.g., displays and lighting) and in future quantum technologies. The recent success of lead halide perovs",{"id":662,"funder":7,"programme":8,"title":663,"piName":10,"institution":26,"country":27,"year":13,"amount":664,"abstract":665},"cordis-european-research-council-award-819496","Organization and learning-associated dynamics of prefrontal synaptic connectivity","€1,880,003","How does experience alter the functional architecture of synaptic connections in neural circuits? This question is particularly pertinent for the complex circuits of the medial prefrontal cortex (mPFC), a high-order associative neocortical area that plays a crucial role in flexible, goal-directed behavior. The mPFC is densely interconnected with cortical and subcortical circuits, and its neurons were shown to undergo substantial experience-dependent structural remodeling that is thought to suppo",{"id":667,"funder":7,"programme":8,"title":668,"piName":10,"institution":580,"country":125,"year":13,"amount":669,"abstract":670},"cordis-european-research-council-award-817708","Surveillance mechanisms regulating nuclear envelope architecture and homeostasis","€1,999,610","The nuclear envelope (NE) is a major hub of eukaryotic cellular organization, influencing a myriad of processes, from gene regulation and repair to cell motility and fate. This central role of the NE depends on its elaborate structure, particularly on the organization of its inner nuclear membrane (INM). This peculiar membrane is continuous with the rest of the endoplasmic reticulum (ER) but faces the nucleoplasm and contains a distinctive set of proteins, which confer a unique identity to the I",{"id":672,"funder":7,"programme":8,"title":673,"piName":10,"institution":106,"country":94,"year":13,"amount":674,"abstract":675},"cordis-european-research-council-award-817639","Beyond Distance Estimates: A New Theory of Heuristics for State-Space Search","€1,997,510","Many problems in computer science can be cast as state-space search, where theobjective is to find a path from an initial state to a goal state in adirected graph called a state space. State-space search is challenging dueto the state explosion problem a.k.a. curse of dimensionality: interestingstate spaces are often astronomically large, defying brute-force exploration.State-space search has been a core research problem in Artificial Intelligencesince its early days and is alive as ever. Every ",{"id":677,"funder":7,"programme":8,"title":678,"piName":10,"institution":138,"country":20,"year":13,"amount":679,"abstract":680},"cordis-european-research-council-award-818625","Epigenome maintenance in response to DNA damage","€1,738,750","Cell viability and homeostasis rely on the stable maintenance of the epigenetic information conveyed by chromatin, which associates DNA and histone proteins in the cell nucleus and governs gene expression programs. Yet, epigenome integrity is challenged during all DNA transactions, including DNA damage repair. While much effort has been devoted to characterizing chromatin alterations in response to DNA damage and how they contribute to the repair response, our knowledge of this fundamental proce",{"id":682,"funder":7,"programme":8,"title":683,"piName":10,"institution":684,"country":20,"year":13,"amount":685,"abstract":686},"cordis-european-research-council-award-819543","Metabolic integration by nutrient SENSing","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","€1,999,391","Nutrient sensing enables metabolic homeostasis by matching energy use with fuel availability. The vast body of knowledge on pro-anabolic nutrient sensors, such as insulin and class 1 phosphoinositol-3 kinase (PI3K) signalling exposed the missing links in molecular coordination of catabolism. The cellular catabolism relies on mitochondrial activities and on lysosomal pathway of autophagy, both paced by the biological clock. However, how pro-catabolic nutrient sensors synchronize these catabolic a",{"id":688,"funder":7,"programme":8,"title":689,"piName":10,"institution":690,"country":132,"year":13,"amount":691,"abstract":692},"cordis-european-research-council-award-817798","Protein Dynamics in Antiviral Processes","TECHNISCHE UNIVERSITAET MUENCHEN","€2,169,555","The innate antiviral defense system is of central importance to protect from viral pathogens. Its ability to mitigate a detrimental outcome of an infectious event relies on interactions that happen between viral and host-derived proteins as well as on signalling cascades that regulate the cellular response. However, despite the importance of these interactions, the involved processes and proteins are not yet fully understood.We established state of the art mass spectrometry techniques and statis",{"id":694,"funder":7,"programme":8,"title":695,"piName":10,"institution":690,"country":132,"year":13,"amount":696,"abstract":697},"cordis-european-research-council-award-771747","Quantum Nanowire Integrated Photonic Circuits","€1,743,850","Semiconductor nanowires (NW) hold very strong potential to advance fundamental and applied research towards new classes of quantized heterostructures in an inherently one-dimensional (1D) geometry. As such, they offer unique possibilities for tunable charge carrier and optical confinement, as well as significant design freedom as optical resonators and waveguides for deterministic integration of isolated emitters into photonic and quantum optical circuits with widespread functionalities. The vas",{"id":699,"funder":7,"programme":8,"title":700,"piName":10,"institution":690,"country":132,"year":13,"amount":701,"abstract":702},"cordis-european-research-council-award-817629","Just-in-time Self-Verification of Autonomous Systems","€1,999,075","Engineers and computer scientists are currently developing autonomous systems whose entire set of behaviors in future, untested situations is unknown: How can a designer foresee all situations that an autonomous road vehicle, a robot in a human environment, an agricultural robot, or an unmanned aerial vehicle will face? Keeping in mind that all these examples are safety-critical, it is irresponsible to deploy such systems without testing all possible situations---this, however, seems impossible ",{"id":704,"funder":7,"programme":8,"title":705,"piName":10,"institution":124,"country":125,"year":13,"amount":55,"abstract":706},"cordis-european-research-council-award-817754","Global and Local Health Impact Assessment of Transport: methods for prioritising model development","Transport is a major determinant of population health.  Adverse health impacts are greatest in lower and middle income cities. Research and policy models are being used to predict how changes in travel patterns and related exposures (e.g. physical activity, air pollution, and road traffic danger) might influence health outcomes (e.g. injuries, heart disease, some cancers and diabetes). However, current methods are not able to produce reliable or comparable results for the questions researchers a",{"id":708,"funder":7,"programme":8,"title":709,"piName":10,"institution":11,"country":12,"year":13,"amount":710,"abstract":711},"cordis-european-research-council-award-818890","Hepatocytes-Like Microreactors for Liver Tissue Engineering","€1,992,289","The global epidemics of obesity and diabetes type 2 lead to higher abundancy of medical conditions like non-alcoholic fatty liver disease causing an increase in liver failure and demand for liver transplants. The shortage of donor organs and the insufficient success in tissue engineering to ex vivo grow complex organs like the liver is a global medical challenge.  ArtHep targets the assembly of hepatic-like tissue, consisting of biological and synthetic entities, mimicking the core structure ele",{"id":713,"funder":7,"programme":8,"title":714,"piName":10,"institution":11,"country":12,"year":13,"amount":715,"abstract":716},"cordis-european-research-council-award-817564","Cliodynamic archaeology: Computational approaches to Final Palaeolithic\u002Fearliest Mesolithic archaeology and climate change","€1,907,638","Late Pleistocene\u002Fearly Holocene Europe is said to be the ideal laboratory for the investigation of human responses to rapidly changing climates and environments, migration and adaptation. Yet, pinpointing precisely how and why contemporaneous Final Palaeolithic\u002Fearliest Mesolithic (15,000-11,000 years BP) foragers migrated, and which environmental or other factors they adapted to – or failed to – has remained remarkably elusive. At the core of ClioArch is the radical but, in light of research-hi",{"id":718,"funder":7,"programme":8,"title":719,"piName":10,"institution":720,"country":721,"year":13,"amount":722,"abstract":723},"cordis-european-research-council-award-815703","Statistical Methods For High Dimensional Diffusions","UNIVERSITE DU LUXEMBOURG","LU","€1,655,048","In the past twenty years the availability of vast dimensional data, typically referred to as big data, has given rise to exciting challenges in various fields of mathematics and computer sciences. The increasing need for getting a better understanding of such data in internet traffic, biology, genetics, and economics, has lead to a revolution in statistical and machine learning, optimisation and numerical analysis. Due to high dimensionality of modern statistical models, parameter estimation is ",{"id":725,"funder":7,"programme":8,"title":726,"piName":10,"institution":727,"country":94,"year":13,"amount":728,"abstract":729},"cordis-european-research-council-award-817582","The Mass Politics of Disintegration","UNIVERSITAT ZURICH","€1,998,626","In the past few years, there has been a growing popular backlash against international institutions. Examples include the 2015 Greek bailout referendum, the 2016 Brexit referendum, or the 2016 election of a US President seemingly determined to withdraw US support from various international treaties. The implications of these mass-based disintegration efforts reach far beyond the countries in which they originate. First, the disintegration process is shaped by how remaining member states respond ",{"id":731,"funder":7,"programme":8,"title":732,"piName":10,"institution":197,"country":75,"year":13,"amount":597,"abstract":733},"cordis-european-research-council-award-819800","Integrating a novel layer of synthetic biology tools in Pseudomonas, inspired by bacterial viruses","As nature’s first bioengineers, bacteriophages have evolved to modify, adapt and control their bacterial hosts through billions of years of interactions. Indeed, like modern synthetic biologists aspire to do, bacteriophages already evade bacterial silencing of their xenogeneic DNA, subvert host gene expression, and co-opt both the central and peripheral metabolisms of their hosts. Studying these key insights from a molecular systems biology perspective, inspired us to develop these evolutionary ",{"id":735,"funder":7,"programme":8,"title":736,"piName":10,"institution":150,"country":75,"year":13,"amount":737,"abstract":738},"cordis-european-research-council-award-818908","The aftermath of slavery in East Africa","€1,921,250","Legacies of slavery tend to affect societies deeply, but in inland East Africa have remained little explored. This project aims [1] to establish what happened to the hundreds of thousands of slaves present in mainland East Africa in ca. 1900 and to their descendants over the twentieth century, [2] to explain why the aftermath of slavery is so little discussed in the written sources and historiography of the region, and [3] to trace the social and political legacies of slavery up to the present. ",{"id":740,"funder":7,"programme":8,"title":741,"piName":10,"institution":727,"country":94,"year":13,"amount":10,"abstract":742},"cordis-european-research-council-award-819394","Deep Integration Agreements","This project aims to improve our understanding of deep integration agreements, which have generated an extraordinary amount of controversy in recent years. Unlike ordinary trade agreements, deep integration agreements do not just focus on reducing tariff barriers but seek to achieve much broader economic integration. Prominent examples include the Transatlantic Trade and Investment Partnership (TTIP) negotiated between the EU and the US and the Comprehensive Economic and Trade Agreement (CETA) n",{"id":744,"funder":7,"programme":8,"title":745,"piName":10,"institution":746,"country":125,"year":13,"amount":55,"abstract":747},"cordis-european-research-council-award-820137","Deciphering and predicting the evolution of cancer cell populations","QUEEN MARY UNIVERSITY OF LONDON","The fundamental evolutionary nature of cancer is well recognized but an understanding of the dynamic evolutionary changes occurring throughout a tumour’s lifetime and their clinical implications is in its infancy. Current approaches to reveal cancer evolution by sequencing of multiple biopsies remain of limited use in the clinic due to sample access problems in multi-metastatic disease. Circulating tumour DNA (ctDNA) is thought to comprehensively sample subclones across metastatic sites. However",{"id":749,"funder":7,"programme":8,"title":750,"piName":10,"institution":138,"country":20,"year":13,"amount":751,"abstract":752},"cordis-european-research-council-award-818066","Random Tensors and Field Theory","€1,672,084","The large-N limit in field theory restricts the perturbative expansion to specific classes of Feynman diagrams. For vectors the restricted class of diagrams is simple, and one can analytically solve the models. For matrices, the large-N limit is simple in zero dimensions but is exceedingly complicated in higher dimensions. I proved that going one step up in the rank and considering tensor fields things simplify again, but not to the level of the vectors. I established the 1\u002FN expansion of random",{"id":754,"funder":7,"programme":8,"title":755,"piName":10,"institution":756,"country":118,"year":13,"amount":757,"abstract":758},"cordis-european-research-council-award-818064","General Embedding Models for Spectroscopy","SCUOLA NORMALE SUPERIORE","€1,609,500","Recently, there has been a paradigmatic shift in experimental molecular spectroscopy, with new methods focusing on the study of molecules embedded within complex supramolecular\u002Fnanostructured aggregates. In the past, molecular spectroscopy has benefitted from the synergistic developments of accurate and cost-effective computational protocols for the simulation of a wide variety of spectroscopies. These methods, however, have been limited to isolated molecules or systems in solution, therefore ar",{"id":760,"funder":7,"programme":8,"title":761,"piName":10,"institution":209,"country":27,"year":13,"amount":762,"abstract":763},"cordis-european-research-council-award-817811","Exploring the Epigenome by Multiplexed Physical Mapping of Individual Chromosomes","€2,750,000","The genome is composed of the genetic code and a rich repertoire of epigenetic chemical DNA modifications, the Epigenome, with distinct signatures in health and disease. Unmasking the interplay between different genomic features is critical for understanding the operating system of life. Specifically, revealing long-range epigenetic regulation may uncover predisposition to cancer. Nevertheless, due to the short read-length of single-cell next-generation sequencing, there is no method today that ",{"id":765,"funder":7,"programme":8,"title":766,"piName":10,"institution":767,"country":41,"year":13,"amount":768,"abstract":769},"cordis-european-research-council-award-818210","CApturing Paradata for documenTing data creation and Use for the REsearch of the future","UPPSALA UNIVERSITET","€1,944,162","Considerable investments have been made in Europe and worldwide in research data infrastructures. Instead of a general lack of data about data, it has become apparent that the pivotal factor that drastically constrains the use of data is the absence of contextual knowledge about how data was created and how it has been used. This applies especially to many branches of SSH research where data is highly heterogeneous, both by its kind (e.g. being qualitative, quantitative, naturalistic, purposeful",{"id":771,"funder":7,"programme":8,"title":772,"piName":10,"institution":300,"country":20,"year":13,"amount":773,"abstract":774},"cordis-european-research-council-award-818823","Coherent diffrAction foR a look Inside Nanostructures towards atomic rEsolution: catalysis and interface","€1,875,000","Heterogeneous catalysis of nanoparticles has recently emerged as highly promising way to speed up catalytic processes due to their far higher surface area compared to bulk materials. But they face significant challenges in achieving high catalytic activity and sufficient durability. A key problem has been that all existing approaches to the characterization of atomic scale phenomena in these materials either lack structural specificity or can be employed under highly unrealistic catalytic enviro",{"id":776,"funder":7,"programme":8,"title":777,"piName":10,"institution":778,"country":179,"year":13,"amount":779,"abstract":780},"cordis-european-research-council-award-819298","Migrant youth mobility in Europe: patterns, processes and consequences","KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW","€1,995,625","Although many immigrant children are more likely to move within the country of settlement than native born youth, little is known on the potential effects of this so called internal mobility. When does childhood internal mobility have negative consequences on an individual’s life? Are there differences in processes and consequences for those of immigrant and non-immigrant background? Do the number of moves or the reason for moving make a difference? Is the age at which moving takes place decisiv",{"id":782,"funder":7,"programme":8,"title":783,"piName":10,"institution":124,"country":125,"year":13,"amount":784,"abstract":785},"cordis-european-research-council-award-818762","Materials Engineering of Integrated Hybrid Spectral Converters for Next Generation Luminescent Solar Devices","€2,124,593","Solar energy conversion will play a key role in our transition to a carbon-neutral society. However, single junction photovoltaic (PV) cells fail to achieve their theoretical efficiency due to an inability to harness all wavelengths of the solar spectrum. Spectral losses may be overcome through the addition of a spectral converter coating to the surface of a finished PV cell, which, through a photoluminescence process, converts solar photons into wavelengths suitable for use. Nonetheless, spectr",{"id":787,"funder":7,"programme":8,"title":788,"piName":10,"institution":789,"country":790,"year":13,"amount":791,"abstract":792},"cordis-european-research-council-award-819046","Principles of retinal neuronal lamination from zebrafish to humans","FUNDACAO GIMM - GULBENKIAN INSTITUTE FOR MOLECULAR MEDICINE","PT","€1,923,750","Neuronal lamination is a hallmark of many diverse brain areas where it is important for efficient circuit formation and neuronal wiring. Despite this significance, the cellular and tissue scale principles that ensure successful and robust lamination are not fully understood. In particular, how cell-tissue interactions and biomechanics influence neuronal lamination is only scarcely explored. To fill this gap, we will use the vertebrate retina with its five neuronal cell types arranged in a highly",{"id":794,"funder":7,"programme":8,"title":795,"piName":10,"institution":241,"country":242,"year":13,"amount":796,"abstract":797},"cordis-european-research-council-award-819202","Respecting safe operating spaces: opportunities to meet future food demand with sustainable use of water and land resources","€1,982,113","Although the human population has quadrupled over the past century, per capita food availability is globally higher than ever - at the expense of environment: scarcity of water and land as well as exceedance of several planetary boundaries. Projected population growth and climate change will further increase the pressure on feeding the planet with sustainably managed natural resources. SOS.aquaterra takes up this challenge by identifying feasible measures to meet future food demand while staying",{"id":799,"funder":7,"programme":8,"title":800,"piName":10,"institution":801,"country":118,"year":13,"amount":802,"abstract":803},"cordis-european-research-council-award-817794","Shapeshifting Metasurfaces for Chemically Selective Augmented Reality","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","€2,745,000","I propose to realize the first shapeshifting optical metasurface that changes its functionality on-demand and adapts to changing external conditions. The metasurface may work as a chemically selective lens that allows transmission only of the spectral fingerprint of a specific molecule in the mid-IR wavelength range. The same metasurface can later be turned into an adaptive lens for focusing and detection under the skin. For such ambitious goal, a radically new approach is needed.I will realize ",{"id":805,"funder":7,"programme":8,"title":806,"piName":10,"institution":209,"country":27,"year":13,"amount":807,"abstract":808},"cordis-european-research-council-award-819080","Deep Learning for Holistic Inference","€1,932,500","Machine learning has rapidly evolved in the last decade, significantly improving accuracy on tasks such as image classification. Much of this success can be attributed to the re-emergence of neural nets. However, learning algorithms are still far from achieving the capabilities of human cognition. In particular, humans can rapidly organize an input stream (e.g., textual or visual) into a set of entities, and understand the complex relations between those. In this project I aim to create a genera",{"id":810,"funder":7,"programme":8,"title":811,"piName":10,"institution":812,"country":125,"year":13,"amount":10,"abstract":813},"cordis-european-research-council-award-819236","African Screen Worlds: Decolonising Film and Screen Studies","SCHOOL OF ORIENTAL AND AFRICAN STUDIES ROYAL CHARTER","A half century since it came into existence, the discipline of Film and Screen Studies remains mostly Eurocentric in its historical, theoretical and critical frameworks. Although “world cinema” and “transnational cinema” scholars have attempted to broaden its canon and frameworks, several major problems persist. Films and scholarship by Africans in particular, and by people of colour in general, are frequently marginalised if not altogether excluded. This prevents exciting exchanges that could h",{"id":815,"funder":7,"programme":8,"title":816,"piName":10,"institution":817,"country":132,"year":13,"amount":818,"abstract":819},"cordis-european-research-council-award-819931","Minor Universality. Narrative World Productions After Western Universalism","UNIVERSITAT DES SAARLANDES","€1,999,310","In her TED Talk 2009 the Nigerian writer Chimamanda Ngozi Adichie made an argument on „the danger of a single story“. She maintained that only plural narrations do justice to the complexity of humankind: „Stories can break the dignity of a people, but stories can also repair that broken dignity.“ Thus narrations have the power to produce a unifying experience of equal humanity. Minor Universality aims to make a substantial contribution to the debate on the problem of universality after Western u",{"id":821,"funder":7,"programme":8,"title":822,"piName":10,"institution":823,"country":34,"year":13,"amount":824,"abstract":825},"cordis-european-research-council-award-814804","Metal-Organic Frameworks as Chemical Reactors for the Synthesis of Well-Defined Sub-Nanometer Metal Clusters","UNIVERSITAT DE VALENCIA","€1,886,000","Humankind advancement is connected to the use and development of metal forms. Recent works have unveiled exceptional properties –such as luminescence, biocompatibility, antitumoral activity or a superlative catalytic activity– for small aggregations of metal atoms, so–called sub–nanometer metal clusters (SNMCs). Despite this importance, the gram-scale synthesis of structurally and electronically well–defined SNMCs is still far from being a reality.The present proposal situates at the centre of s",{"id":827,"funder":7,"programme":8,"title":828,"piName":10,"institution":138,"country":20,"year":13,"amount":829,"abstract":830},"cordis-european-research-council-award-820133","Compact THz lasers based on graphene quantum dots","€1,998,596","The ambition of this project is to open new horizons in the field of graphene-based devices for THz technology. The major objective is to develop compact THz amplifiers and lasers operating at room temperature, analogous to the concept of semiconductor lasers in the visible and telecom wavelength range. THz radiation is extremely attractive for fundamental investigations of matter and emerging applications including, for example, security screening, medical imaging and spectroscopy. However, the",{"id":832,"funder":7,"programme":8,"title":833,"piName":10,"institution":178,"country":179,"year":13,"amount":55,"abstract":834},"cordis-european-research-council-award-819588","CRYSTAL CLEAR: determining the impact of charge on crystal nucleation","All of the crystals that form in water on Earth are formed through reaction between oppositely charged ions. In these crystals, the ions are present in an ideal, charge-balanced ionic ratio. In contrast, the natural solutions in which they form, contain widely diverging ionic ratios. When crystals nucleate from natural solutions, they will be charged, and charge has a massive impact on the behaviour of small new crystals. Most nucleation experiments have been conducted in solutions with charge-b",{"id":836,"funder":7,"programme":8,"title":837,"piName":10,"institution":838,"country":132,"year":13,"amount":517,"abstract":839},"cordis-european-research-council-award-818949","Reprogramming Conformation by Fluorination: Exploring New Areas of Chemical Space","UNIVERSITAET MUENSTER","Despite the abundance of organic compounds in Nature, only 12 contain fluorine. In contrast, fluorinated organic materials account for over 40% of all pharmaceuticals and agrochemicals. Closer inspection of the fluorination patterns in these functional molecules reveals striking extremes towards perfluorination (in both 2D and 3D scaffolds) or single site fluorination predominantly in aryl substituents. Consequently, most fluorinated moieties in functional materials lack stereochemical informati",{"id":841,"funder":7,"programme":8,"title":842,"piName":10,"institution":388,"country":94,"year":13,"amount":843,"abstract":844},"cordis-european-research-council-award-819318","Infinite Protein Self-Assembly in Health and Disease","€2,574,819","Understanding how proteins respond to mutations is of paramount importance to biology and disease. While protein stability and misfolding have been instrumental in rationalizing the impact of mutations, we recently discovered that an alternative route is also frequent, where mutations at the surface of symmetric proteins trigger novel self-interactions that lead to infinite self-assembly. This mechanism can be involved in disease, as in sickle-cell anemia, but may also serve in adaptation. Impor",{"id":846,"funder":7,"programme":8,"title":847,"piName":10,"institution":580,"country":125,"year":13,"amount":848,"abstract":849},"cordis-european-research-council-award-819131","Monetary Economics and Communication: New Data, New Tools, New and Old Questions","€1,560,516","In the last 25 years, communication has become a core lever of monetary policy. This has important implications for academic research in monetary economics -- an area intrinsically linked to the policy environment. The framework change raises new questions, and we must rethink how we empirically study existing questions. We need new approaches and new data. My ground-breaking research agenda, rooted in important academic questions, comprises of 6 pioneering projects across 3 related themes that ",{"id":851,"funder":7,"programme":8,"title":852,"piName":10,"institution":853,"country":132,"year":13,"amount":854,"abstract":855},"cordis-european-research-council-award-819642","Genome-wide surveys and functional analysis of pancreatic cancer metastasis drivers","KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)","€1,995,875","Metastasis is the major cause of death in pancreatic ductal adenocarcinoma (PDAC). International sequencing efforts on >800 human primaries gave comprehensive insights into PDAC genetics. In contrast, equivalent studies for “metastasis genetics” were not possible, largely because of a lack of metastatic tissue resources, particularly of treatment-naive ones. Another bottleneck is the scarcity of adequate experimental models recapitulating the multi-step nature of metastasis. As a consequence, th",{"id":857,"funder":7,"programme":8,"title":858,"piName":10,"institution":311,"country":41,"year":13,"amount":859,"abstract":860},"cordis-european-research-council-award-819540","Brain cell type-specific interactions and schizophrenia","€2,064,414","Schizophrenia is a heritable but genetically complex disease. Pathological and epidemiological data fit a model of SCZ as a network disease with perturbations during brain development leading to early-adulthood onset clinical symptomatology. Our present understanding is based on single markers or arrays of gene expression from tissue samples containing multiple cell types. As a consequence, pathological changes in the function of inhibitory or excitatory neurons, microglia, or oligodendrocytes h",{"id":862,"funder":7,"programme":8,"title":863,"piName":10,"institution":864,"country":132,"year":13,"amount":139,"abstract":865},"cordis-european-research-council-award-819531","Gene therapy of inherited and acquired hearing loss","MEDIZINISCHE HOCHSCHULE HANNOVER","To address the substantial financial and social burden caused by hearing loss in 360 million people world-wide, I aim to improve hearing via gene therapy to correct inherited and protect from acquired hearing loss. In vitro experiments will establish the best vector configurations for transfer of therapeutic genes and miRNAs into inner ear hair cells (HC) and spiral ganglion neurons (SGN). The efficiency of the best-performing vector designs will then be explored in vivo using fluorescent marker",{"id":867,"funder":7,"programme":8,"title":868,"piName":10,"institution":253,"country":179,"year":13,"amount":55,"abstract":869},"cordis-european-research-council-award-817868","The Reconfiguration of Whiteness in China: Privileges, Precariousness, and Racialized Performances","This research examines the multiple and contradictory constructions of whiteness in China as a result of the rapid diversification of white migrants in the country and the shifting power balances between China and the West. Existing literature on white westerners in Asia mainly focuses on transnational elites. The rising number of middle- and lower-stratum of white migrants in China deserves special attention due to substantial tensions and discrepancies in their experiences of racial privilege,",{"id":871,"funder":7,"programme":8,"title":872,"piName":10,"institution":265,"country":125,"year":13,"amount":873,"abstract":874},"cordis-european-research-council-award-819533","Addressing Global Challenges through International Scientific Consortia (INSCONS);  Case studies in biomedicine, the geosciences, and nuclear fusion research","€1,997,021","INSCONS is a groundbreaking, large-scale examination of the organisational dynamics of international scientific consortia (ISCs) and the interactions of these consortia with broader scientific communities, national bureaucracies, and industry. ISCs are very complex organisations with work being carried out at geographically dispersed sites, and involving international stakeholder groups from across the realms of science, policy, and industry. As these ISCs are becoming more important in efforts ",{"id":876,"funder":7,"programme":8,"title":877,"piName":10,"institution":878,"country":179,"year":13,"amount":55,"abstract":879},"cordis-european-research-council-award-817834","Exploring Asgard archaea to illuminate the prokaryote-to-eukaryote transition","WAGENINGEN UNIVERSITY","The origin of the eukaryotic cell, with its complex structural features, marks one of the prime hallmarks in the evolution of life on Earth. Still, the events that led to the emergence of cellular complexity in eukaryotic cells are a matter of hot debate. Current data supports scenarios in which an archaeal host cell and an alphaproteobacterial (mitochondrial) endosymbiont merged, triggering the emergence of the first eukaryotic cell. The host cell was recently shown to share a common ancestry w",{"id":881,"funder":7,"programme":8,"title":882,"piName":10,"institution":838,"country":132,"year":13,"amount":883,"abstract":884},"cordis-european-research-council-award-817652","CORRECTING INEQUALITY THROUGH LAW: HOW COURTS CONCEPTUALIZE EQUALITY IN THEIR CONSTITUTIONAL JURISPRUDENCE","€1,606,597","Equality is one of the main political concerns of our time. Rising economic inequality is often cited as a major reason for the recent rise of political populism. But economic inequality is not the only problem. Inequalities based on gender, race or nationality are also major issues in the contemporary discussion. While most commentators discuss political solutions, the proposed research project analyzes the contributions that courts can make to correct inequalities. Norms protecting equality fo",{"id":886,"funder":7,"programme":8,"title":887,"piName":10,"institution":888,"country":68,"year":13,"amount":889,"abstract":890},"cordis-european-research-council-award-817190","Chemistry and interface tailored lead-free relaxor thin films for energy storage capacitors","SILICON AUSTRIA LABS GMBH","€1,996,519","The goal of CITRES is to provide new energy storage devices with high power and energy density by developing novel multilayer ceramic capacitors (MLCCs) based on relaxor thin films (RTF). Energy storage units for energy autonomous sensor systems for the Internet of Things (IoT) must possess high power and energy density to allow quick charge\u002Frecharge and long-time energy supply. Current energy storage devices cannot meet those demands: Batteries have large capacity but long charging\u002Fdischarging ",{"id":892,"funder":7,"programme":8,"title":893,"piName":10,"institution":894,"country":125,"year":13,"amount":895,"abstract":896},"cordis-european-research-council-award-819864","Wall-Crossing and Algebraic Geometry","THE UNIVERSITY OF EDINBURGH","€1,999,840","We will establish stability conditions and wall-crossing in derived categories as a standard methodology for a wide range of fundamental problems in algebraic geometry. Previous work based on wall-crossing, in particular my joint work with Macri, has led to breakthroughs on the birational geometry of moduli spaces and related varieties. Recent advances have made clear that the power of stability conditions extends far beyond this setting, allowing us to study vanishing theorems or bounds on glob",{"id":898,"funder":7,"programme":8,"title":899,"piName":10,"institution":235,"country":125,"year":13,"amount":10,"abstract":900},"cordis-european-research-council-award-816268","Building Precise Molecular Architectures to Unlock Remarkable f-Element Properties","The astonishing properties of the f-elements have been exploited in numerous consumer technologies, despite their fundamental chemistry being poorly developed. It is now crucial to address this issue to provide the necessary insights to develop future applications. Design criteria exist to build f-element complexes with maximised physical attributes. This adventurous proposal targets the synthesis and thorough analysis of two complementary molecular f-element architectures that 1) optimise magne",{"id":902,"funder":7,"programme":8,"title":903,"piName":10,"institution":904,"country":118,"year":13,"amount":905,"abstract":906},"cordis-european-research-council-award-819789","Efficient algorithms for sustainable machine learning","UNIVERSITA DEGLI STUDI DI GENOVA","€1,977,500","This project will  develop and integrate the latest optimization and statistical advances into a new generation of  resource-efficient algorithms for large-scale machine learning. State-of-the-art machine learning methods provide impressive results, opening new perspectives for science, technology, and society. However,  they  rely on massive computational resources to process huge manually annotated data-sets. The corresponding costs in terms of energy consumption and human efforts are not sust",{"id":908,"funder":7,"programme":8,"title":909,"piName":10,"institution":910,"country":118,"year":13,"amount":517,"abstract":911},"cordis-european-research-council-award-819160","Programmable nucleic acid toolkits for cell-free diagnostics and genetically encoded biosensing","UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA","WHY: The biological complexity of tumours and the large diversity of diagnostic biomarkers call for the development of innovative analytical tools that can detect multiple targets in a sensitive, specific and low-cost way and allow real-time monitoring of disease pathways and therapeutic effects. To provide such transformative tools creative thinking, innovative approach and the exploration of new research avenues that span different disciplines is necessary. WHAT: The goal of the PRO-TOOLKITS p",{"id":913,"funder":7,"programme":8,"title":914,"piName":10,"institution":915,"country":75,"year":13,"amount":916,"abstract":917},"cordis-european-research-council-award-817762","Foundations for Higher and Curved Noncommutative Algebraic Geometry","UNIVERSITEIT ANTWERPEN","€1,171,360","With this research programme, inspired by open problems within noncommutative algebraic geometry (NCAG) as well as by actual developments in algebraic topology, it is our aim to lay out new foundations for NCAG. On the one hand, the categorical approach to geometry put forth in NCAG has seen a wide range of applications both in mathematics and in theoretical physics. On the other hand, algebraic topology has received a vast impetus from the development of higher topos theory by Lurie and others.",{"id":919,"funder":7,"programme":8,"title":920,"piName":10,"institution":921,"country":132,"year":13,"amount":466,"abstract":922},"cordis-european-research-council-award-818635","DNA-based functional lattices","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","Nature has evolved astonishingly diverse structures where the nanoscale assembly of components is key to their functionality. Such nanostructures self-assemble at massive scales and at spatial resolutions surpassing top-down production techniques. The leaves of a single tree, e.g., can cover the area of 10.000 m^2 while every mm^2 contains more than 10^8 highly efficient light-harvesting complexes. For future photovoltaic devices, light-managing surfaces and photonic devices it will thus be bene",{"id":924,"funder":7,"programme":8,"title":925,"piName":10,"institution":265,"country":125,"year":13,"amount":926,"abstract":927},"cordis-european-research-council-award-819752","The Developmental Origins of Health: Biology, Shocks, Investments, and Policies","€1,738,763","What are the origins of inequalities in health? A recent literature in economics has established causal impacts of early life shocks, investments and policies on lifelong health. However, several unknowns remain. The mechanisms through which shocks, investments, and policies interact are just beginning to be understood. Our knowledge of sensitive periods is imprecise. Little is also known about the impact of shocks and policies across different ages. Commonly used health capital measures, such a",{"id":929,"funder":7,"programme":8,"title":930,"piName":10,"institution":26,"country":27,"year":13,"amount":55,"abstract":931},"cordis-european-research-council-award-818858","Navigating lymphatic formation and function  in health and disease","For many years, lymphatic vessels have been viewed as inert fluid conduits whose open structure allows for passive flow of antigens, proteins and cells from peripheral tissues to lymphoid organs. Yet, recent discoveries highlighting novel functions and heterogeneous origins of the lymphatic endothelium, call for reevaluation of the passive lymphatic-vessel paradigm. During the past decade, we have used the zebrafish (ZF) to detail the cellular and molecular events underlying the development of t",{"id":933,"funder":7,"programme":8,"title":934,"piName":10,"institution":935,"country":125,"year":13,"amount":936,"abstract":937},"cordis-european-research-council-award-817988","Cultural Values and the International Trade in Medieval European Manuscripts, c. 1900-1945","UNIVERSITY OF LONDON","€1,832,711","CULTIVATE MSS aims to assess the significance of the trade in medieval manuscripts for the development of ideas about the nature and value of European culture in the early 20th century, a crucial period for the development of modern European nation states. Although recent technological developments have facilitated quantitative analyses of provenance data, charting in increasing detail the early-20th-century movement of manuscripts, including an exodus of works to America, qualitative analyses h",{"id":939,"funder":7,"programme":8,"title":940,"piName":10,"institution":746,"country":125,"year":13,"amount":941,"abstract":942},"cordis-european-research-council-award-819600","Form and Function of the Mitochondrial Retrograde Response","€1,450,060","The molecular communication between mitochondria and nucleus is an integrated bi-directional crosstalk - anterograde (nucleus to mitochondria) and retrograde (mitochondria to nucleus) signalling pathways. The mitochondrial retrograde response (MRR) is driven by defective mitochondrial function, which increases cytosolic reactive oxygen species (ROS) and Ca2+. Metabolic reprogramming is a key feature in highly proliferative cells to meet the energy needs for rapid growth by generating substrates ",{"id":944,"funder":7,"programme":8,"title":945,"piName":10,"institution":946,"country":947,"year":13,"amount":948,"abstract":949},"cordis-european-research-council-award-819461","Unlikely refuge? Refugees and citizens in East-Central Europe in the 20th century","MASARYKUV USTAV A ARCHIV AV CR VVI","CZ","€1,995,950","The project aims to write refugees back into the history of East-Central Europe in the 20th century. In this “age of refugees”, the region became a destination of large refugee migrations, forcing civil societies and governments to negotiate difficult decisions about protection for those fleeing the war and persecution. Yet, at the same time, East-Central Europe does not enjoy the reputation as a welcoming place for people persecuted for political persuasion, for their “racial”, ethnic identity ",{"id":951,"funder":7,"programme":8,"title":952,"piName":10,"institution":953,"country":132,"year":13,"amount":173,"abstract":954},"cordis-european-research-council-award-819957","Laser Resonance Chromatography of Superheavy Metals","JOHANNES GUTENBERG-UNIVERSITAT MAINZ","This project aims at developing a novel method of optical spectroscopy to study the wholly unexplored atomic structure of the superheavy transition metals, starting with element 103, lawrencium (Lr). My team will experimentally identify optical spectral lines that will serve as fingerprints in the search for superheavy elements in the universe. The spectral lines are strongly influenced by relativistic and quantum electrodynamic effects and thus will constitute powerful benchmarks for atomic mod",{"id":956,"funder":7,"programme":8,"title":957,"piName":10,"institution":958,"country":283,"year":13,"amount":959,"abstract":960},"cordis-european-research-council-award-818791","Visual Culture, Piety and Propaganda: Transfer and Reception of Russian Religious Art in the Balkans and the Eastern Mediterranean (16th to early 20th Century)","IDRYMA TECHNOLOGIAS KAI EREVNAS","€1,914,670","The Russian religious artefacts (icons and ecclesiastical furnishings) held in museums, church or monastery collections in the Balkans and Eastern Mediterranean constitute a body of valuable monuments hitherto largely neglected by historians and historians of art. These objects acquire various interrelated religious\u002Fideological, political and aesthetic meanings, value and uses. Their transfer and reception is a significant component of the larger process of transformation of the artistic languag",{"id":962,"funder":7,"programme":8,"title":963,"piName":10,"institution":801,"country":118,"year":13,"amount":964,"abstract":965},"cordis-european-research-council-award-818669","Multi-Parameter Live-Cell Observation of Biomolecular Processes with Single-Photon Detector Array","€1,861,250","Fluorescence single-molecule (SM) detection techniques have the potential to provide insights into the complex functions, structures and interactions of individual, specifically labelled biomolecules. However, current SM techniques work properly only when the biomolecule is observed in controlled environments, e.g., immobilized on a glass surface. Observation of biomolecular processes in living (multi)cellular environments – which is fundamental for sound biological conclusion – always comes wit",{"id":967,"funder":7,"programme":8,"title":968,"piName":10,"institution":969,"country":75,"year":13,"amount":970,"abstract":971},"cordis-european-research-council-award-818859","Technological Change: New Sources, Consequences, and Impact Mitigation","UNIVERSITE CATHOLIQUE DE LOUVAIN","€1,268,900","Technological change in information technology has the potential of transforming the production process of firms. Some processes such as automation affect workers directly, while others such as the introduction of automated workflow and control tools simply allow firms to grow to bigger sizes. We call the latter Quantity-Biased Technological Change (QBTC). The existing literature has done relatively little to understand the effects of such technological progress that affects the size and structu",{"id":973,"funder":7,"programme":8,"title":974,"piName":10,"institution":150,"country":75,"year":13,"amount":975,"abstract":976},"cordis-european-research-council-award-818607","PrOcess intensification and innovation in olefin ProducTIon by Multiscale Analysis and design","€1,995,000","New manufacturing techniques such as 3D printing have the potential to drastically transform the chemical industry. Novel, complex, integrated reactor designs can now be created, that will allow to unlock alternative chemical routes, such as for methane activation. Driven by process intensification and the power of high performance computing, this project will enhance heat and mass transfer in advanced chemical reactors by multiscale modelling and experimentation. OPTIMA aims to:(1) develop in s",{"id":978,"funder":7,"programme":8,"title":979,"piName":10,"institution":980,"country":41,"year":13,"amount":981,"abstract":982},"cordis-european-research-council-award-820187","Dynamic Complexes and Allosteric Regulation of  Small Molecule Transporters","STOCKHOLMS UNIVERSITET","€1,999,875","Solute Carrier (SLC) transporters mediate the translocation of substrates across membranes and after GPCRs represent the second-largest fraction of the human membrane proteome. SLC transporters are critical to cell homeostasis, which is reflected in the fact that more than a quarter is associated with Mendelian disease. Despite a few exceptions, however, they have been under-utilized as drug targets and most of the mechanistic understanding has been derived from bacterial homologues of these med",{"id":984,"funder":7,"programme":8,"title":985,"piName":10,"institution":986,"country":132,"year":13,"amount":10,"abstract":987},"cordis-european-research-council-award-819960","Pathways to humanity: Adaptive niche diversity at the origins of the human lineage","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","For almost 100 years, the evolution of humans has been summarized as a transition from small-brained bipeds with an ape-like body plan (referred to as australopiths), to large-brained striding bipeds with a human-like body plan (members of the genus Homo). This characterisation dominates popular perception of human evolution in the public sphere. However, three newly discovered fossil human (hominin) species (H. naledi, H. floresiensis and Australopithecus sediba) do not fit this simple transiti",{"id":989,"funder":7,"programme":8,"title":990,"piName":10,"institution":991,"country":132,"year":13,"amount":992,"abstract":993},"cordis-european-research-council-award-820148","Next generation algorithms for grabbing and exploiting symmetry","TECHNISCHE UNIVERSITAT DARMSTADT","€1,999,094","Symmetry is a phenomenon that appears in many different contexts. Algorithmic symmetry detection and exploitation is the concept of finding intrinsic symmetries of a given object and then using these symmetries to our advantage. Application areas of algorithmic symmetry detection and exploitation range from convolutional neural networks in machine learning to computer graphics, chemical data bases and beyond. In contrast to this widespread use, our understanding of the theoretical foundation (na",{"id":995,"funder":7,"programme":8,"title":996,"piName":10,"institution":997,"country":132,"year":13,"amount":981,"abstract":998},"cordis-european-research-council-award-819894","Matching CNS Lineage Maps with Molecular Brain Tumor Portraits for Translational Exploitation","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","Brain tumors represent an extremely heterogeneous group of more than 100 different molecularly distinct diseases, many of which are still almost uniformly lethal despite five decades of clinical trials. In contrast to hematologic malignancies and carcinomas, the cell-of-origin for the vast majority of these entities is unknown. This knowledge gap currently precludes a comprehensive understanding of tumor biology and also limits translational exploitation (e.g., utilizing lineage targets for nove",{"id":1000,"funder":7,"programme":8,"title":1001,"piName":10,"institution":1002,"country":179,"year":13,"amount":1003,"abstract":1004},"cordis-european-research-council-award-817540","The influence of stellar outflows on exoplanetary mass loss","UNIVERSITEIT LEIDEN","€1,999,956","ASTROFLOW aims to make ground-breaking progress in our physical understanding of exoplanetary mass loss, by quantifying the influence of stellar outflows on atmospheric escape of close-in exoplanets. Escape plays a key role in planetary evolution, population, and potential to develop life. Stellar irradiation and outflows affect planetary mass loss: irradiation heats planetary atmospheres, which inflate and more likely escape; outflows cause pressure confinement around otherwise freely escaping ",{"id":1006,"funder":7,"programme":8,"title":1007,"piName":10,"institution":93,"country":94,"year":13,"amount":1008,"abstract":1009},"cordis-european-research-council-award-820091","ThermoacOustic instabilities contRol in sequential Combustion cHambers","€2,585,170","A new type of combustor architecture for large gas turbines has emerged in recent years: sequential combustion systems operated at constant pressure. This major technology change results from the need for more operationally and fuel flexible gas turbines, for future sustainable energy networks. As for regular gas turbines, the risk of combustor breakdown due to thermoacoustic instabilities is a major challenge. While the harmful consequences of these instabilities in novel sequential combustors ",{"id":1011,"funder":7,"programme":8,"title":1012,"piName":10,"institution":1013,"country":132,"year":13,"amount":1014,"abstract":1015},"cordis-european-research-council-award-820124","Knowledge based design of complex synthetic microbial communities for plant protection","EBERHARD KARLS UNIVERSITAET TUEBINGEN","€1,925,500","Complex microbial communities (microbiota) that populate surfaces of higher organisms critically impact health of their hosts: They contribute to vital functions such as host fitness, nutrient acquisition, stress tolerance and pathogen resistance but are, at the same time, reservoirs for facultative pathogens or can promote pathogenesis. How and why communities shift from a beneficial to a detrimental state is largely unknown and we are far from utilizing identified mechanisms.  In order to cure",{"id":1017,"funder":7,"programme":8,"title":1018,"piName":10,"institution":1019,"country":94,"year":13,"amount":1020,"abstract":1021},"cordis-european-research-council-award-818994","Accelerating mass loss of Greenland: firn and the shifting runoff limit","UNIVERSITE DE FRIBOURG","€1,989,181","Meltwater running off the flanks of the Greenland ice sheet contributes roughly 60% to its mass loss, the rest being due to calving. Only meltwater originating from below the elevation of the runoff limit leaves the ice sheet, contributing to mass loss; melt at higher elevations refreezes in the porous firn and does not drive mass loss. Therefore any shift in the runoff limit modifies mass loss and subsequent sea level rise. New evidence shows surface runoff at increasingly high elevations, outp",{"id":1023,"funder":7,"programme":8,"title":1024,"piName":10,"institution":271,"country":48,"year":13,"amount":1025,"abstract":1026},"cordis-european-research-council-award-818523","The History of Intellectual Property Rights in the Creative Industries","€1,926,210","CREATIVE IPR aims to study the rise of intellectual property rights in the creative industries, from the international treaties of the late nineteenth century to the present day, with a focus on Europe in the global world. CREATIVE IPR examines the consequences of this development for the creators. What did intellectual property rights mean to a musician, or to a fashion designer in twentieth century Europe? Who captured economic value or failed to do so? In order to answer these questions, CREA",{"id":1028,"funder":7,"programme":8,"title":1029,"piName":10,"institution":586,"country":179,"year":13,"amount":1030,"abstract":1031},"cordis-european-research-council-award-819299","Repurposing small RNA from ciliates for genome editing: single-molecule study","€1,792,850","Genome editing is an essential tool for life sciences. Recent ground-breaking discovery in microbiology drew our attention to the genome editing ability of bacteria (CRISPR). Since its discovery, CRISPR has revolutionized the way of editing a genome. Despite its wide use, CRISPR-genome editing has limitations, especially in the use for medical applications. Numerous studies have shown that it suffers from the off-target effect. Its use is also restricted by its particular sequence requirement an",{"id":1033,"funder":7,"programme":8,"title":1034,"piName":10,"institution":1035,"country":34,"year":13,"amount":55,"abstract":1036},"cordis-european-research-council-award-819814","Human Subcortical-Cortical Circuit Dynamics for Remembering the Exceptional","UNIVERSIDAD POLITECNICA DE MADRID","Our memory system is optimised for remembering the exceptional over the mundane. We remember better those events that violate predictions generated by the prevailing context, particularly because of surprise or emotional impact. Understanding how we form and retrieve long-term memories for important or salient events is critical for combating the rapidly growing incidence of pathologies associated with memory dysfunction with huge socio-econonomic burden. Human lesion and non-invasive functional",{"id":1038,"funder":7,"programme":8,"title":1039,"piName":10,"institution":289,"country":94,"year":13,"amount":1040,"abstract":1041},"cordis-european-research-council-award-820047","Timing of Holocene volcanic eruptions and their radiative aerosol forcing","€1,978,923","Volcanic eruptions play a dominant role in driving climate, in ways beyond the established short-term influence on surface air temperatures. In order to mitigate and adapt to the climate effects of future large volcanic eruptions we need to better quantify the risk of these eruptions including 1) the probability of their occurrence and 2) their expected climatic impact. The observational record of the timing of volcanic eruptions, their locations, magnitudes of sulphate aerosol injection is inco",{"id":1043,"funder":7,"programme":8,"title":1044,"piName":10,"institution":138,"country":20,"year":13,"amount":1045,"abstract":1046},"cordis-european-research-council-award-819261","REflection Matrix ImagiNg In wave SCiENCE","€1,999,705","In wave imaging, we aim at characterizing an unknown environment by actively probing it and then recording the waves reflected by the medium. It is, for example, the principle of ultrasound imaging, optical coherence tomography for light or reflection seismology in geophysics. However, wave propagation from the sensors to the focal plane is often degraded by the heterogeneities of the medium itself. They can induce wave-front distortions (aberrations) and multiple scattering events that can stro",{"id":1048,"funder":7,"programme":8,"title":1049,"piName":10,"institution":1050,"country":61,"year":13,"amount":10,"abstract":1051},"cordis-european-research-council-award-819143","CIPHER: Hip Hop Interpellation (Le Conseil International pour Hip Hop et Recherche \u002F The International Council for Hip Hop Studies)","UNIVERSITY COLLEGE CORK -  NATIONAL UNIVERSITY OF IRELAND, CORK","CIPHER will launch the global research initiative, Hip Hop Interpellation, pilot a new semantic digital\u002Fethnographic web methodology, and codify the emergent discipline of global hip hop studies. It addresses the central question: why has this highly localized and authenticizing African American music translated so easily to far-flung communities and contexts around the globe? Through this specific question the project attempts to understand the foundational and broadly transferable question: ho",{"id":1053,"funder":7,"programme":8,"title":1054,"piName":10,"institution":150,"country":75,"year":13,"amount":517,"abstract":1055},"cordis-european-research-council-award-819459","Novel Echoes. Ancient Novelistic Receptions and Concepts of Fiction in Late Antique and Medieval Secular Narrative from East to West","This project offers the first comprehensive reconstruction and interpretation of receptions of ancient novels (1st-4th cent. AD) in (Greek, Arabic and western vernacular) secular narrative from Late Antiquity and the early Middle Ages. Novel Echoes follows up from the ERC Starting Grant project Novel Saints (on hagiography). It does so by taking ancient novelistic receptions towards entirely new, unexplored horizons. Our knowledge about the early history of the novel is incomplete. Receptions of",{"id":1057,"funder":7,"programme":8,"title":1058,"piName":10,"institution":986,"country":132,"year":13,"amount":1059,"abstract":1060},"cordis-european-research-council-award-819585","Symbiont-assisted cuticle biosynthesis as a key innovation contributing to the evolutionary success of beetles","€1,997,750","To elucidate the key adaptations underlying evolutionary success remains one of the central challenges in evolution and ecology. However, rigorous experimental tests are usually hampered by the lack of replicate evolutionary events or the inability to manipulate a candidate trait of importance. SYMBeetle exploits the naturally replicated evolution of an experimentally tractable, symbiont-assisted key adaptation in beetles to understand its impact on niche expansion and diversification. Recent ev",{"id":1062,"funder":7,"programme":8,"title":1063,"piName":10,"institution":915,"country":75,"year":13,"amount":55,"abstract":1064},"cordis-european-research-council-award-815128","3D Structure of Nanomaterials under Realistic Conditions","The properties of nanomaterials are essentially determined by their 3D structure. Electron tomography enables one to measure the morphology and composition of nanostructures in 3D, even at atomic resolution. Unfortunately, all these measurements are performed at room temperature and in ultra-high vacuum, which are conditions that are completely irrelevant for the use of nanoparticles in real applications! Moreover, nanoparticles often have ligands at their surface, which form the interface to th",{"id":1066,"funder":7,"programme":8,"title":1067,"piName":10,"institution":93,"country":94,"year":13,"amount":1068,"abstract":1069},"cordis-european-research-council-award-815464","Unified Theory of Efficient Optimization and Estimation","€1,993,320","The goal of this project is to make progress toward a unified theory of efficientoptimization and estimation. In many computing applications, especially machine learning,optimization and estimation problems play an increasingly important role. For that reason, a largeresearch effort is devoted to developing and understanding the limitations of efficient algorithmsfor these problems. For many of these problems, achieving the best known provable guaranteesrequired the use of algorithms that are ta",{"id":1071,"funder":7,"programme":8,"title":1072,"piName":10,"institution":1073,"country":179,"year":13,"amount":55,"abstract":1074},"cordis-european-research-council-award-819075","Supramolecular machineries with life-like mechanical functions","RIJKSUNIVERSITEIT GRONINGEN","Artificial molecular motors and switches have the potential to become a core part of nanotechnology. However, a wide gap in length scales still remains unaccounted for, between the operation of these molecules in solution, where their individual mechanical action is randomly dispersed in the Brownian storm, and on the other hand their action at the macroscopic level, e.g. in polymer networks and crystals. This proposal is about bridging this gap, by developing chemo-mechanical transduction strat",{"id":1076,"funder":7,"programme":8,"title":1077,"piName":10,"institution":727,"country":94,"year":13,"amount":1078,"abstract":1079},"cordis-european-research-council-award-819229","Regulation of Brain Macrophage Development and Function","€1,995,500","Macrophages are part of the mononuclear phagocyte system and play critical roles in innate immune responses. They further exert crucial organ-specific functions to warrant tissue homeostasis. Most macrophages are long-lived and derive from embryonic precursors. The central nervous system (CNS) contains several macrophage populations, of which microglia are the most prominent and abundant population residing in the CNS parenchyma. Besides being implicated in CNS pathologies, microglia guide neuro",{"id":1081,"funder":7,"programme":8,"title":1082,"piName":10,"institution":1083,"country":34,"year":13,"amount":1084,"abstract":1085},"cordis-european-research-council-award-819134","Extending Coherence for Hardware-Driven Optimizations in Multicore Architectures","UNIVERSIDAD DE MURCIA","€1,999,955","Multicore processors are present nowadays in most digital devices, from smartphones to high-performanceservers. The increasing computational power of these processors is essential for enabling many importantemerging application domains such as big-data, media, medical, or scientific modeling. A fundamentaltechnique to improve performance is speculation, a technique that consists in executing work before it isknown if it is actually needed. In hardware, speculation significantly increases energy ",{"id":1087,"funder":7,"programme":8,"title":1088,"piName":10,"institution":449,"country":132,"year":13,"amount":1089,"abstract":1090},"cordis-european-research-council-award-820254","2D Materials for Quantum Technology","€1,806,250","Since its discovery, graphene has been indicated as a promising platform for quantum technologies (QT). The number of theoretical proposal dedicated to this vision has grown steadily, exploring a wide range of directions, ranging from spin and valley qubits, to topologically-protected states. The experimental confirmation of these ideas lagged so far significantly behind, mostly because of material quality problems. The quality of graphene-based devices has however improved dramatically in the p",{"id":1092,"funder":7,"programme":8,"title":1093,"piName":10,"institution":178,"country":179,"year":13,"amount":55,"abstract":1094},"cordis-european-research-council-award-819219","Cellular Logistics: Form, Formation and Function of the Neuronal Microtubule Cytoskeleton","The organization and dynamics of the MT (MT) cytoskeleton underlies the morphology, polarization and division of most cells. The structural polarity of MT determines the directionality of motor proteins, which move selectively towards either the MT plus (most kinesins) or minus end (dynein) to control the transport and positioning of proteins and organelles. Understanding how different cellular MT arrays, such as the mitotic spindle or neuronal MT networks, are built and utilized to ensure prope",{"id":1096,"funder":7,"programme":8,"title":1097,"piName":10,"institution":727,"country":94,"year":13,"amount":1098,"abstract":1099},"cordis-european-research-council-award-820152","Microbial genome defence pathways: from molecular mechanisms to next-generation molecular tools","€1,996,525","The constant arms race between prokaryotic microbes and their molecular parasites such as viruses, plasmids and transposons has driven the evolution of complex genome defence mechanisms. The CRISPR-Cas defence systems provide adaptive RNA-guided immunity against invasive nucleic acid elements. CRISPR-associated effector nucleases such as Cas9, Cas12a and Cas13 have emerged as powerful tools for precision genome editing, gene expression control and nucleic acid detection. However, these technolog",{"id":1101,"funder":7,"programme":8,"title":1102,"piName":10,"institution":81,"country":34,"year":13,"amount":1103,"abstract":1104},"cordis-european-research-council-award-819623","Ferrites-by-design for Millimeter-wave and Terahertz Technologies","€1,989,967","Robust disruptive materials will be essential for the “wireless everywhere” to become a reality.  This is because we need a paradigm shift in mobile communications to meet the challenges of such an ambitious evolution. In particular, some of these emerging technologies will trigger the replacement of the magnetic microwave ferrites in use today. This will namely occur with the forecasted shift to high frequency mm-wave and THz bands and in novel antennas that can simultaneously transmit and rece",200,{"programme":8,"total":1107,"withPiName":1108,"firstYear":1109,"lastYear":1110,"countryCount":1111,"perYear":1112,"topInstitutions":1152,"topCountries":1221},4499,349,2014,2027,45,[1113,1115,1118,1121,1124,1127,1129,1132,1135,1138,1141,1144,1147,1150],{"year":1109,"count":1114},303,{"year":1116,"count":1117},2015,335,{"year":1119,"count":1120},2016,322,{"year":1122,"count":1123},2017,327,{"year":1125,"count":1126},2018,403,{"year":13,"count":1128},300,{"year":1130,"count":1131},2020,277,{"year":1133,"count":1134},2021,321,{"year":1136,"count":1137},2022,364,{"year":1139,"count":1140},2023,359,{"year":1142,"count":1143},2024,366,{"year":1145,"count":1146},2025,375,{"year":1148,"count":1149},2026,416,{"year":1110,"count":1151},31,[1153,1156,1159,1162,1165,1168,1171,1173,1175,1178,1180,1183,1186,1188,1190,1193,1196,1199,1202,1205,1207,1210,1213,1216,1219],{"name":1154,"count":1155},"Centre National de la Recherche Scientifique CNRS",229,{"name":1157,"count":1158},"University of Oxford",89,{"name":1160,"count":1161},"Weizmann Institute of Science",78,{"name":1163,"count":1164},"University of Cambridge",77,{"name":1166,"count":1167},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",63,{"name":1169,"count":1170},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",55,{"name":1172,"count":1170},"Institut National de la Sante Et de la Recherche Medicale",{"name":1174,"count":1170},"Kobenhavns Universitet",{"name":1176,"count":1177},"Universiteit Utrecht",51,{"name":1179,"count":1177},"University College London",{"name":1181,"count":1182},"Tel Aviv University",49,{"name":1184,"count":1185},"The Hebrew University of Jerusalem",43,{"name":1187,"count":1185},"Universiteit Gent",{"name":1189,"count":1185},"Universiteit van Amsterdam",{"name":1191,"count":1192},"Ludwig-Maximilians-Universitaet Muenchen",42,{"name":1194,"count":1195},"Technische Universitaet Muenchen",41,{"name":1197,"count":1198},"Eidgenoessische Technische Hochschule Zuerich",40,{"name":1200,"count":1201},"Universitat Wien",39,{"name":1203,"count":1204},"Helsingin Yliopisto",38,{"name":1206,"count":1204},"Technische Universiteit Delft",{"name":1208,"count":1209},"Katholieke Universiteit Leuven",37,{"name":1211,"count":1212},"Universitetet I Oslo",36,{"name":1214,"count":1215},"École Polytechnique Fédérale de Lausanne",34,{"name":1217,"count":1218},"The University of Edinburgh",32,{"name":1220,"count":1151},"Lunds Universitet",[1222,1224,1226,1228,1230,1232,1234,1236,1237,1239,1241,1243,1245,1247,1249,1251,1253,1256,1257,1260,1262,1265,1268,1271,1273],{"name":132,"count":1223},810,{"name":125,"count":1225},559,{"name":20,"count":1227},490,{"name":179,"count":1229},428,{"name":34,"count":1231},315,{"name":118,"count":1233},267,{"name":27,"count":1235},219,{"name":94,"count":1105},{"name":41,"count":1238},170,{"name":75,"count":1240},166,{"name":68,"count":1242},146,{"name":12,"count":1244},127,{"name":242,"count":1246},94,{"name":48,"count":1248},85,{"name":61,"count":1250},82,{"name":790,"count":1252},68,{"name":1254,"count":1255},"GB",47,{"name":947,"count":1212},{"name":1258,"count":1259},"HU",24,{"name":283,"count":1261},22,{"name":1263,"count":1264},"US",21,{"name":1266,"count":1267},"PL",20,{"name":1269,"count":1270},"TR",14,{"name":721,"count":1272},13,{"name":1274,"count":1275},"EE",8]