[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-consolidator-grant-2020":3,"awarded-stats-erc-consolidator-grant":1099},{"awarded":4,"total":1098},[5,16,21,28,34,39,44,49,56,62,66,72,77,83,90,96,103,109,115,121,128,134,138,144,149,154,160,165,171,176,181,186,191,196,203,208,213,218,223,228,233,238,242,248,253,258,264,270,276,280,286,291,296,301,307,313,319,325,331,337,342,348,354,359,364,370,375,381,386,392,396,402,408,413,418,423,428,433,438,443,448,454,460,467,473,479,486,492,499,504,509,515,521,527,532,537,543,548,555,560,566,571,576,580,586,591,596,603,608,615,620,626,632,637,643,648,654,660,665,671,677,682,687,693,699,704,709,716,722,728,733,738,744,750,755,760,764,769,774,779,785,791,797,801,806,812,817,822,827,832,838,843,848,853,858,863,867,872,878,882,888,893,898,902,908,913,918,924,929,933,939,943,949,954,960,966,972,978,984,989,994,1000,1005,1010,1015,1020,1024,1029,1035,1041,1046,1052,1056,1062,1068,1073,1078,1082,1086,1092],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-865738","European Research Council","ERC Consolidator Grant","Resurrecting the Carboxyl Polyether Ionophores",null,"AARHUS UNIVERSITET","DK",2020,"€1,998,864","The carboxyl polyether ionophores (CPIs) is a class of >150 complex natural products. Belonging to the most complicated of Nature's secondary metabolites, they are darlings within total chemical synthesis, however, the biological role of these agents is obscure. Due to their canonical function of equilibrating ion-gradients across biological membranes, CPIs are thought to be unspecific and largely uninteresting. Here, I will advocate and demonstrate the opposite position: that not only are these",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":11,"country":12,"year":13,"amount":19,"abstract":20},"cordis-european-research-council-award-866240","EXpansion and Phenotype Loss Of SMCs In Atherosclerosis: Causal effects and therapeutic possibilities","€1,998,875","Atherosclerosis is considered an inflammatory disease caused by the accumulation, modification and immune cell recognition of low-density lipoproteins in the arterial wall. Plaque macrophages are held to be the main drivers of disease activity, whereas smooth muscle cells (SMCs) have traditionally been considered protective by forming fibrous tissue that stabilises plaques from undergoing rupture and causing thrombosis.In the present project, we challenge this dichotomous view of cellular villai",{"id":22,"funder":7,"programme":8,"title":23,"piName":10,"institution":24,"country":25,"year":13,"amount":26,"abstract":27},"cordis-european-research-council-award-864686","Safe data-driven control for human-centric systems","TECHNISCHE UNIVERSITAET MUENCHEN","DE","€1,999,975","Many control systems of the future involve a tight interaction or even symbiosis with the human user. High-impact application domains of human-centric systems include healthcare, mobility, and infrastructure systems. In human-centric systems the human is both, an element of the control system, and a design criterion with individual requirements that need to be satisfied. Safety - despite the high uncertainty of human behavior - and maximization of individual user experience are the primary objec",{"id":29,"funder":7,"programme":8,"title":30,"piName":10,"institution":31,"country":32,"year":13,"amount":10,"abstract":33},"cordis-european-research-council-award-819169","Physico-Chemistry of Carbonaceous Aerosol Pollution in Evolving Cities","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","FR","Carbonaceous aerosols (organic and black carbon) remain a major unresolved issue in atmospheric science, especially in urban centers, where they are one of the dominant aerosol constituents and among most toxic to human health. The challenge is twofold: first, our understanding of the sources, sinks and physico-chemical properties of the complex mixture of carbonaceous species is still incomplete; and second, the representation of urban heterogeneities in air quality models is inadequate as they",{"id":35,"funder":7,"programme":8,"title":36,"piName":10,"institution":24,"country":25,"year":13,"amount":37,"abstract":38},"cordis-european-research-council-award-864234","Solar-to-Chemical Energy Conversion with  Advanced Nitride Semiconductors","€1,933,750","As photovoltaic technologies gain prominence, an outstanding challenge is the development of systems that can robustly store solar energy with high density. Within this context, the capture of sunlight and its direct conversion to chemical fuels in artificial photosystems provides a promising route for sustainably meeting future energy demands. However, a central challenge is the lack of systems that can efficiently direct light excitations towards desired chemical products with high efficiency ",{"id":40,"funder":7,"programme":8,"title":41,"piName":10,"institution":24,"country":25,"year":13,"amount":42,"abstract":43},"cordis-european-research-council-award-865615","Evolution of gut-associated microbial communities and its functional relevance in health and disease","€1,999,085","The gut is a highly dynamic microbial ecosystem that controls human health through its collective metabolic activities. Microbial communities form metabolic networks that are essential for dietary breakdown, production of bioactive metabolites and resistance to infections. Bacterial lineages making up these networks evolve rapidly to adapt to the microbial, metabolic and immune environment of the gut. The lack of suitable model systems has limited our current understanding of the relevance of mi",{"id":45,"funder":7,"programme":8,"title":46,"piName":10,"institution":24,"country":25,"year":13,"amount":47,"abstract":48},"cordis-european-research-council-award-863850","Spatio-Temporal Methods for Data-driven Computer Animation and Simulation","€1,998,750","Numerical simulations are of tremendous importance for a wide range of scientific disciplines and commercial enterprises. For the majority of these natural phenomena, we not only need to consider the three spatial dimensions, but additionally we need to resolve how these phenomena develop over time. Thus, most natural simulations inherently need to resolve four dimensional functions, and most effects at human scales require fine discretizations along all four axes. As a consequence, these functi",{"id":50,"funder":7,"programme":8,"title":51,"piName":10,"institution":52,"country":53,"year":13,"amount":54,"abstract":55},"cordis-european-research-council-award-820213","Thinking Ahead: human planning from a predictive processing perspective","CONSIGLIO NAZIONALE DELLE RICERCHE","IT","€1,898,757","Humans have an impressive ability to form action plans in several domains of cognition; for example, planning routes to goals in spatial navigation, or the necessary steps to assemble complex objects, alone or together with other persons. However, the computations that underlie human individual and social planning remain largely unknown. This proposal aims to explain the ways humans face three key forms of uncertainty arising in planning domains; namely, uncertainty about task structure, action ",{"id":57,"funder":7,"programme":8,"title":58,"piName":10,"institution":59,"country":32,"year":13,"amount":60,"abstract":61},"cordis-european-research-council-award-864832","BioInspired Clicked Siderophore-Antibiotics","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","€2,000,000","The frightening increase in antibiotic drug resistance is threatening global healthcare as we know it. To this extent the World Health Organisation that has classes M. tuberculosis and Gram-negative nosocomial infections as the highest priority for novel R&D strategies. A major obstacle to drug discovery programs is to design inhibitors that can efficiently enter into bacteria. One such stealth strategy is exemplified by natural siderophore-antibiotics conjugates (sideromycins) that piggyback th",{"id":63,"funder":7,"programme":8,"title":64,"piName":10,"institution":59,"country":32,"year":13,"amount":60,"abstract":65},"cordis-european-research-council-award-864219","Exposure to ‘cocktails’ of food additives and chronic disease risk","Today, our daily diet typically contains dozens of food additives (e.g. colours, emulsifiers, sweeteners: ~350 substances allowed on the EU market). Safety assessment is performed by health agencies to protect consumers against potential adverse effects of each additive, yet such an assessment is only based on current available evidence, i.e., for most additives, only in-vitro\u002Fin-vivo toxicological studies and exposure simulations. Meanwhile, the long-term health impact of additives intake and a",{"id":67,"funder":7,"programme":8,"title":68,"piName":10,"institution":69,"country":32,"year":13,"amount":70,"abstract":71},"cordis-european-research-council-award-864729","Non-invasive decoding of brain communication patterns to ease motor restoration after stroke","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","€1,999,720","Human-computer interfaces are increasingly explored to facilitate interaction with the external world. Brain-computer interfaces (BCIs), bypassing the skeletomuscular system, are particularly promising for assisting paralyzed people in control and communication, but also for boosting neuromotor rehabilitation. Despite their potential, the societal impact of BCIs is dramatically limited by the poor usability in real-life applications. While many solutions have been proposed - from the identificat",{"id":73,"funder":7,"programme":8,"title":74,"piName":10,"institution":59,"country":32,"year":13,"amount":75,"abstract":76},"cordis-european-research-council-award-865592","Oncometabolitic control of tumor growth and epileptogenesis in IDH mutated gliomas: D2HG signaling mechanism.","€1,875,135","Dysregulated growth processes of gliomas interact with pro-epileptic plasticity of brain circuits in such a way that the excitatory transmitter glutamate promotes autocrine tumor invasion as well as epileptic synchrony in surrounding cortical regions. Most low-grade gliomas are associated with mutations of Isocitrate DesHydrogenase (IDH) genes which lead to an excess of the oncometabolite D-2-Hydroxyglutarate (D2HG). With a structure mimicking glutamate, D2HG is thought to participate in both ep",{"id":78,"funder":7,"programme":8,"title":79,"piName":10,"institution":80,"country":25,"year":13,"amount":81,"abstract":82},"cordis-european-research-council-award-818941","A platform to LINk between CHemistry and PhysIcs of colloidal Nanomaterials","UNIVERSITY OF HAMBURG","€1,964,375","The recent successful applications of photon-in-photon-out spectroscopy in condense matter physics, bio-inorganic chemistry and catalysis build upon the high brilliance of modern X-ray sources and realization of dedicated emission spectrometers. However, probing with highly energetic X-ray beam puts many constraints on the sample environment and requires probing faster than the X-ray radiation damage occurs. This strongly limits the applicability of the method in studying the chemistry of colloi",{"id":84,"funder":7,"programme":8,"title":85,"piName":10,"institution":86,"country":87,"year":13,"amount":88,"abstract":89},"cordis-european-research-council-award-818089","Artificial metabolic cells for biomanufacturing of bio-based chiral fine chemicals","ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE","ES","€1,995,894","One of the major challenges of sustainable chemistry is expanding the palette of bio-based chemicals that can replace, or at least ameliorate, the exploitation of fuel-based chemicals.  Cell-free metabolic engineering using soluble enzymes is an emerging and versatile approach that seeks to increase the selectivity and productivity of chemical biomanufacturing processes. However, soluble and isolated enzymes present major issues in terms of efficiency, stability and re-usability that hamper indu",{"id":91,"funder":7,"programme":8,"title":92,"piName":10,"institution":93,"country":94,"year":13,"amount":10,"abstract":95},"cordis-european-research-council-award-819877","The Foundations of Institutional AuThority: a multi-dimensional model of the separation of powers","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","IE","‘Almost three centuries later, it is past time to rethink Montesquieu’s holy trinity’ (Ackerman, 2010).As Ackerman (and many others) have observed, political reality has long left the traditional model of the separation of powers behind. The problems posed by this gap between constitutional theory and political practice have recently acquired fresh urgency as developments in Hungary, Poland, Turkey, Russia, the UK, US, Bolivia and elsewhere place the separation of powers under strain. These incl",{"id":97,"funder":7,"programme":8,"title":98,"piName":10,"institution":99,"country":100,"year":13,"amount":101,"abstract":102},"cordis-european-research-council-award-818473","Real-time Data-Informed Multi-scale Computational Methods for Material Design and Processing","TECHNISCHE UNIVERSITEIT EINDHOVEN","NL","€1,999,632","The fundamental importance of materials to modern society is evidenced by the way new materials have revolutionized almost every aspect of our lives. Despite the many advances, dwindling resources and more stringent demands on product cost and performance demand increasingly better material designs and production processes, resulting in a heightened reliance on computational methods.In the field of computational materials engineering, the recent emergence of data science into the mainstream is c",{"id":104,"funder":7,"programme":8,"title":105,"piName":10,"institution":106,"country":87,"year":13,"amount":107,"abstract":108},"cordis-european-research-council-award-811234","ENgineering FrustratiOn in aRtificial Colloidal icEs: degeneracy, exotic lattices and 3D states","UNIVERSITAT DE BARCELONA","€1,850,298","Geometric frustration, namely the impossibility of satisfying competing interactions on a lattice, has recentlybecome a topic of considerable interest as it engenders emergent, fundamentally new phenomena and holdsthe exciting promise of delivering a new class of nanoscale devices based on the motion of magnetic charges.With ENFORCE, I propose to realize two and three dimensional artificial colloidal ices and investigate thefascinating manybody physics of geometric frustration in these mesoscopi",{"id":110,"funder":7,"programme":8,"title":111,"piName":10,"institution":112,"country":25,"year":13,"amount":113,"abstract":114},"cordis-european-research-council-award-818862","Exploring the Limits of High Potential Oxidizers Prediction, Validation and Preparation of Unusual Molecules at the Edge of Stability","FREIE UNIVERSITAET BERLIN","€1,988,280","The very well-known concept of formal oxidation states, used e. g. for redox reactions is one of the most fundamental ones in general chemistry. However, in the area of very strong oxidizers even the familiar oxido(-II) ligand becomes redox-innocent and assigning oxidation states becomes ambiguous. Very strong (super-) oxidizers are compounds whose oxidizing strength exceeds that of elemental F2. Anyhow, not only molecular oxidizer but also their interaction with the environment in different med",{"id":116,"funder":7,"programme":8,"title":117,"piName":10,"institution":118,"country":25,"year":13,"amount":119,"abstract":120},"cordis-european-research-council-award-818343","Philosophy and Genre: Creating a Textual Basis for African Philosophy","UNIVERSITAT BAYREUTH","€1,997,762","The project pioneers a multilingual approach to African philosophy, based on an understanding of philosophy as expressed through texts. In contrast to definitions of philosophical texts as non-fictional, written sources (Hountondji), we insist on a much more inclusive definition of “text”: both oral and written texts, fictional and non-fictional ones, public and private ones are considered in this project. A rigorous study of texts, working across multiple genres and several languages, is the fi",{"id":122,"funder":7,"programme":8,"title":123,"piName":10,"institution":124,"country":125,"year":13,"amount":126,"abstract":127},"cordis-european-research-council-award-819753","ChaperoneRegulome: Understanding cell-type-specificity of chaperone regulation","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","UK","€1,992,500","Protein misfolding causes devastating health conditions such as neurodegeneration. Although the disease-causing protein is widely expressed, its misfolding occurs only in certain cell-types such as neurons. What governs the susceptibility of some tissues to misfolding is a fundamental question with biomedical relevance. Molecular chaperones help cellular proteins fold into their native conformation. Despite the generality of their function, chaperones are differentially expressed across various ",{"id":129,"funder":7,"programme":8,"title":130,"piName":10,"institution":131,"country":25,"year":13,"amount":132,"abstract":133},"cordis-european-research-council-award-866411","Computational Hematopathology for Improved Diagnostics","HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH","€1,981,213","Identifying hematologic malignancies still relies on the time-consuming and subjective visual assessment of images. Every day, cytologists and pathologists are confronted with rare diagnostic cells, ever-increasing image data, and heterogeneous disease manifestations. Although we understand blood better than any other human tissue, we are unable to quantitatively predict a patient’s blood dynamics from a measurement. Diagnosis thus depends on rough staging schemes and the expertise and intuition",{"id":135,"funder":7,"programme":8,"title":136,"piName":10,"institution":69,"country":32,"year":13,"amount":10,"abstract":137},"cordis-european-research-council-award-864313","NUMERICAL MODELLING OF HEMODYNAMICS AND PHARMACOKINETICS FOR CLINICAL TRANSLATION","Surgical interventions often require vascular procedures consisting in cutting vessels, removing organ parts or suturing new connections. Intervention planning is based on patient data and surgeons experience. Even the best plans are often revised in real-time during surgery. Can we understand and predict blood flow changes due to a surgery? Complex interactions must be foreseen between three scales:  the local point of intervention, whole organ perfusion and function, and the entire circulation",{"id":139,"funder":7,"programme":8,"title":140,"piName":10,"institution":141,"country":32,"year":13,"amount":142,"abstract":143},"cordis-european-research-council-award-865963","Preparation of Subduction Earthquakes: Slow, Deep, Large-scale trigger","UNIVERSITE GRENOBLE ALPES","€1,998,920","Subduction zones host the worlds largest earthquakes and tsunamis. Understanding how such earthquakes initiate and interact is a first-order challenge in earth sciences. A puzzling and unexplained observation is that megathrust earthquakes seem to be clustering at the scale of the plate boundary. This suggests that the subducting slab plays an important role, albeit downplayed, in the triggering of megathrust earthquakes.I propose to study subduction zones recently affected by megathrust events ",{"id":145,"funder":7,"programme":8,"title":146,"piName":10,"institution":31,"country":32,"year":13,"amount":147,"abstract":148},"cordis-european-research-council-award-863412","Simulating particle acceleration within black hole magnetospheres","€1,330,322","Black holes are involved in extreme astrophysical phenomena such as accretion, launching of relativistic jets and particle acceleration. The origin of this activity is still poorly understood, but plasma processes within the magnetosphere of the black hole are most likely involved. Thanks to high-performance computing, it is now possible to probe this region. The current state-of-the-art numerical simulations have been focusing on a fluid description of the plasma surrounding black holes. This a",{"id":150,"funder":7,"programme":8,"title":151,"piName":10,"institution":31,"country":32,"year":13,"amount":152,"abstract":153},"cordis-european-research-council-award-864850","Geo-inspired pathways towards nanoparticle-based metastable solids","€1,999,577","Constant search of new solids is required to advance our knowledge in materials science, and then to stimulate progresses in fields like energy and environment. Genesis aims at expanding the collection of functional inorganic solids as nanoparticles by rational exploratory synthesis. The pivotal idea is to draw inspiration from the processes of solid formation encountered in natural geological processes, in order to set a framework of synthesis conditions prone to yield new nanoscaled solids.I f",{"id":155,"funder":7,"programme":8,"title":156,"piName":10,"institution":157,"country":125,"year":13,"amount":158,"abstract":159},"cordis-european-research-council-award-865227","Distributional Macroeconomics in the Long and Short Run","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","€1,598,433","A key development in the “dismal science” has been the incorporation of explicit heterogeneity into models of the macroeconomy. As a result of taking micro data seriously, these theories study macroeconomic questions in terms of distributions of microeconomic variables like income or wealth rather than just aggregates. This approach opens up the door to examining the distributional implications of macroeconomic trends, shocks or policies, and to examine the two-way interaction between these dist",{"id":161,"funder":7,"programme":8,"title":162,"piName":10,"institution":31,"country":32,"year":13,"amount":163,"abstract":164},"cordis-european-research-council-award-863473","Making Sense of Electrical Noise by Simulating Electrolyte Solutions","€1,781,893","Seemingly unrelated experiments such as electrolyte transport through nanotubes, nano-scale electrochemistry, NMR relaxometry and Surface Force Balance measurements, all probe electrical fluctuations: of the electric current, the charge and polarization, the field gradient (for quadrupolar nuclei) and the coupled mass\u002Fcharge densities. If only we had the theoretical tools to interpret this electrical noise, we would open complementary windows on ionic systems. Such insight is needed, as recent e",{"id":166,"funder":7,"programme":8,"title":167,"piName":10,"institution":168,"country":125,"year":13,"amount":169,"abstract":170},"cordis-european-research-council-award-864751","Structural basis of controlling the membrane attack complex","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€1,999,990","Structural basis of controlling the membrane attack complexComplement is a fundamental component of the human immune system; central to the battle between hosts and pathogens. The membrane attack complex (MAC) is the direct killing arm of complement that acts by forming large pores in target cell membranes. Uncontrolled activation results in by-stander damage, which can have devastating consequences for host cells and impact inflammatory pathologies, thrombosis and cancer. Understanding how MAC ",{"id":172,"funder":7,"programme":8,"title":173,"piName":10,"institution":168,"country":125,"year":13,"amount":174,"abstract":175},"cordis-european-research-council-award-865127","Financing Frictions in High-Potential Entrepreneurship","€1,590,330","Entrepreneurship is widely accepted as a key driver of economic growth and is a central policy priority across the world, including in the EU through initiatives such as the EUs Entrepreneurship 2020 Action Plan.While access to capital is viewed as one of the biggest hurdles to starting and growing a new business, the manner in which financing constraints for startups are invoked in academic work and policy frameworks is often poorly fleshed out. This lack of clarity is also reflected in the way",{"id":177,"funder":7,"programme":8,"title":178,"piName":10,"institution":168,"country":125,"year":13,"amount":179,"abstract":180},"cordis-european-research-council-award-864055","Predicting Outcome of Rate or Rhythm Control in Patients with Atrial Fibrillation and Heart Failure","€1,998,927","Heart failure (HF) and atrial fibrillation (AF) are common co-morbidities (AF-HF). AF-HF is prevalent in Europe with high rates of hospitalisation and death. AF-HF patients have two treatment options: rate control, where AF is not treated but drugs are used to slow the heart rate, or rhythm control, where AF is treated to restore sinus rhythm. Rate control is the first-line treatment, yet specific patient groups do much better under rhythm control. Identifying patients that will do best under rh",{"id":182,"funder":7,"programme":8,"title":183,"piName":10,"institution":31,"country":32,"year":13,"amount":184,"abstract":185},"cordis-european-research-council-award-865724","NanophononIcs for QUantum information procEssing","€1,999,900","Over the past thirty years, the remarkable technological advances in microfabrication processes have thrust mechanical vibrations into the quantum realm. The intrinsic coherence of mechanical motion and the capability to couple it to other physical degrees of freedom hold promises of scalable hybrid quantum platforms. But mechanical vibrations are also powerful conveyors of physical information. They are ubiquitously used in wireless communication systems, where bulk and surface acoustic wave (B",{"id":187,"funder":7,"programme":8,"title":188,"piName":10,"institution":141,"country":32,"year":13,"amount":189,"abstract":190},"cordis-european-research-council-award-866001","Exoplanet Adaptive Characterization with the ELT","€2,744,119","This proposals objective is to mature two novel technological developments to push the limits of high-contrast imaging at high-spectral resolution with the near-future extremely large telescope (ELT). I will replicate in the laboratory the observing conditions of the ELT, and the expected spectra of a variety of planets and stars using tunable lasers. First, the high-contrast imaging system of HARMONI will be emulated to produce realistic datacubes onto which post-processing algorithms will be a",{"id":192,"funder":7,"programme":8,"title":193,"piName":10,"institution":31,"country":32,"year":13,"amount":194,"abstract":195},"cordis-european-research-council-award-866267","Exploring antiferromagnetic order at the nanoscale with a single spin microscope","€1,675,037","EXAFONIS objectives venture into the emerging field of antiferromagnetic (AF) spintronics. By exploiting the unique performances offered by scanning NV-magnetometry, two major objectives will be pursued. The first objective aims at providing a comprehensive and thorough analysis of the microscopic mechanisms at the origin of AF manipulation when subjected to different external stimuli, including strain, electric fields and spin-polarized currents. Such studies still remain an almost uncharted re",{"id":197,"funder":7,"programme":8,"title":198,"piName":10,"institution":199,"country":200,"year":13,"amount":201,"abstract":202},"cordis-european-research-council-award-866489","Partner choice and the evolution of cooperation","ASSOCIACAO BIOPOLIS","PT","€1,999,335","Cooperation represents an evolutionary puzzle because natural sCooperation poses an evolutionary problem because natural selection is thought to favour cheaters over co-operators. However, theory and studies in humans show us that co-operators are preferred over cheaters as social and sexual partners. Partner choice may therefore provide a powerful explanation for the evolution and stability of cooperation, alongside kin selection and self-serving benefits, but we lack an understanding of its im",{"id":204,"funder":7,"programme":8,"title":205,"piName":10,"institution":31,"country":32,"year":13,"amount":206,"abstract":207},"cordis-european-research-council-award-864550","Motor cortical beta bursts for movement planning and evaluation: Mechanisms, functional roles, and development","€1,988,189","Each of us performs thousands of actions during the course of daily tasks, ranging from relatively simple (e.g. clicking on a mouse button), to highly complex (e.g. holding a sheet of paper in one hand while using scissors to cut it in a straight line with the other). All of these actions involve an intricate interplay between sensory integration, muscle coordination, and movement evaluation processes. Motor cortical activity in the beta frequency range (13-30Hz) is a hallmark signature of healt",{"id":209,"funder":7,"programme":8,"title":210,"piName":10,"institution":31,"country":32,"year":13,"amount":211,"abstract":212},"cordis-european-research-council-award-865826","Higgs mode in Superconductors","€1,877,588","Collective modes are witnesses of their underlying quantum order, such as superconductivity. Experimental observations of the collective amplitude mode of the superconducting state, named the Higgs mode due to its analogy with the high energy particle, are still scarce and controversial, despite being a fundamental outcome of the theory of superconductivity. Besides, many crucial questions remain open, like the mechanism of its observability, its mere existence in two-dimensional or unconvention",{"id":214,"funder":7,"programme":8,"title":215,"piName":10,"institution":31,"country":32,"year":13,"amount":216,"abstract":217},"cordis-european-research-council-award-865995","Shape-Shifting Ultrathin 2D Colloidal NanoPlatelets","€1,958,000","Mechanical instabilities of thin sheets has long been exploited in Nature to create patterns and ensure vital functions such as stimuli responsiveness. By applying forces at the surface of thin objects, it is possible to create a wide variety of chiral 3D shapes such as helices, twists and rolls. Moreover, minute changes on these forces can induce dramatic shape-shifting between different geometries. Our goal is to use this general principle to establish a new class of chiral and addressable nan",{"id":219,"funder":7,"programme":8,"title":220,"piName":10,"institution":31,"country":32,"year":13,"amount":221,"abstract":222},"cordis-european-research-council-award-863487","Ultra-strong light-matter coupling in quantum infrared detectors","€1,550,627","In the majority of optoelectronic devices emission and absorption of light are considered as perturbative phenomena. The objective of my project is to explore the ultra-strong light-matter coupling regime in a new type of optoelectronic semiconductor-based devices operating in the THz and MIR frequency range (lambda=3-300m). These devices will allow the first time experimental observation of intrinsically quantum features of the ultra-strong coupling regime, such as quantum vacuum radiation (dyn",{"id":224,"funder":7,"programme":8,"title":225,"piName":10,"institution":31,"country":32,"year":13,"amount":226,"abstract":227},"cordis-european-research-council-award-865151","Emergent topology in photon fluids","€1,999,973","The discovery of topological phases of matter has revolutionised the understanding of solid state physics in the past 40 years. Their main hallmark is the appearance of propagating edge states robust to backscattering at the interface between two solids of different topologies. This paradigm has been able to successfully ex-plain electronic phenomena such as the universal edge transport in the quantum Hall effect and the exist-ence of topological insulators. Recently, these concepts have been br",{"id":229,"funder":7,"programme":8,"title":230,"piName":10,"institution":31,"country":32,"year":13,"amount":231,"abstract":232},"cordis-european-research-council-award-863481","PT-symmetric electronic structure theory","€1,895,636","Processes related to electronically excited states are central in chemistry, physics, and biology, playing a key role in ubiquitous processes such as photochemistry, catalysis, and solar cell technology. However, defining an effective method that reliably provides accurate excited-state energies remains a major challenge in theoretical chemistry. In PTEROSOR, we aim at developing a totally novel approach to obtain excited-state energies and wave functions in molecular sys- tems thanks to the pro",{"id":234,"funder":7,"programme":8,"title":235,"piName":10,"institution":31,"country":32,"year":13,"amount":236,"abstract":237},"cordis-european-research-council-award-866365","Topological Superconductivity in Graphene","€2,044,178","In recent years, a considerable stream of work from the condensed matter community has been focusing on hybrid systems coupling superconductors to various topological states of matter. Such a heterogeneous coupling is pivotal in enabling the emergence of new excitations the Majorana or parafermion that could be used as quantum bits (qubits) with unique properties of non-locality and immunity to external perturbations, essential to encode and manipulate quantum information in a robust and stable ",{"id":239,"funder":7,"programme":8,"title":240,"piName":10,"institution":124,"country":125,"year":13,"amount":10,"abstract":241},"cordis-european-research-council-award-864174","Musical and Poetic Creativity for A Unique Moment in the Western Christian Liturgy, c.1000-1500","BENEDICAMUS pursues a transformative focus on creative practices surrounding a particular moment in the Western Christian liturgy: the exclamation Benedicamus Domino (“Let us Bless the Lord”), which sounded in song several times a day from c.1000 to 1500. This moment was granted special musical licence c.1000: singers of plainchant melodies could choose to reprise a favourite tune from the Church music for the day, re-texting it with the words Benedicamus Domino. In consequence, Benedicamus Domi",{"id":243,"funder":7,"programme":8,"title":244,"piName":10,"institution":245,"country":246,"year":13,"amount":60,"abstract":247},"cordis-european-research-council-award-863486","The Emergence, Life, and Demise of Autocratic Regimes","UNIVERSITETET I OSLO","NO","ELDAR will investigate three aspects of autocratic politics: 1) the emergence of autocratic regimes; 2) policy-making (“life”) in autocracies in the areas of education, infrastructure, pensions and media regulation; 3) autocratic regime breakdown. ELDAR offers a comprehensive perspective, highlighting the interconnections between these three aspects – for example, the particular policies chosen may mitigate or exacerbate specific risks to the regime – and studying them jointly in one framework. ",{"id":249,"funder":7,"programme":8,"title":250,"piName":10,"institution":245,"country":246,"year":13,"amount":251,"abstract":252},"cordis-european-research-council-award-866357","4DSpace: integrated study for space weather at high latitudes","€1,999,111","Ionosphere is the partially ionized, outermost part of the Earths atmosphere. Its dynamics is inherently complex and affected by dynamic conditions in the solar wind. In the polar regions, it is directly coupled to the Earths magnetosphere and space plasma. The polar ionosphere is subject to the auroral particle precipitation, instabilities and turbulence, which all influence the energy transfer through the ionosphere and lead to plasma density irregularities which lead to scintillations of tran",{"id":254,"funder":7,"programme":8,"title":255,"piName":10,"institution":245,"country":246,"year":13,"amount":256,"abstract":257},"cordis-european-research-council-award-865971","Storyworlds in Transition: Coptic Apocrypha in Changing Contexts in the Byzantine and Early Islamic Periods","€1,998,626","This project proposes the first systematic study of Coptic apocrypha covering the entire timespan of Coptic literary production, and it aims to do so with unprecedented methodological sophistication. Apocrypha is here defined as (1) texts and traditions that develop or expand upon characters and events of the biblical storyworld; (2) and\u002For contain a claim to authorship by a character from that storyworld or a direct witness to it. A great number of such apocryphal texts and traditions has been ",{"id":259,"funder":7,"programme":8,"title":260,"piName":10,"institution":261,"country":53,"year":13,"amount":262,"abstract":263},"cordis-european-research-council-award-865067","Armenia Entangled:  Connectivity and Cultural Encounters in Medieval Eurasia","UNIVERSITA DEGLI STUDI DI FIRENZE","€1,999,994","ArmEn seeks to establish a new framework for studying the southern Caucasus, eastern Anatolia and northern Mesopotamia (CAM) as a space of cultural entanglements between the 9th to 14th centuries. It argues that this region is key to understanding the history of medieval Eurasia but has so far been completely neglected by the burgeoning field of Global Middle Ages. The CAM was on the crossroads of expanding Eurasian empires and population movements, but was removed from major hubs of power. Poly",{"id":265,"funder":7,"programme":8,"title":266,"piName":10,"institution":267,"country":94,"year":13,"amount":268,"abstract":269},"cordis-european-research-council-award-864522","Investigating the role of the inner retina in age-related macular degeneration (AMD)","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","€1,999,455","Age-related macular degeneration (AMD) is the leading cause of irreversible central blindness in the world. The number of people with AMD is predicted to be 196 million by 2020, with an estimated 1 in 10 people over the age of 55 already showing early signs of the condition.  Identifying those individuals at greater risk of disease progression is challenging and robust animal models of disease are delaying the development of therapeutics. We have recently discovered that the blood vessels of the",{"id":271,"funder":7,"programme":8,"title":272,"piName":10,"institution":273,"country":100,"year":13,"amount":274,"abstract":275},"cordis-european-research-council-award-864660","When Flows Turn Turbulent in the Supercritical Fluid Region","TECHNISCHE UNIVERSITEIT DELFT","€1,924,020","From concentrated solar power plants to rocket engines, energy conversion systems are continually re-engineered to perform ever better. Often this involves fluids being pushed into the supercritical region, where highly non-ideal thermodynamic effects are at play. Yet, our fundamental understanding of flow physics at such conditions lags behind to successfully realize these exciting engineering applications. Especially, the sharp variations in thermophysical properties and the high optical densi",{"id":277,"funder":7,"programme":8,"title":278,"piName":10,"institution":273,"country":100,"year":13,"amount":60,"abstract":279},"cordis-european-research-council-award-864016","Seeing the invisible: Light-based 3D imaging of opaque nanostructures","Nanostructures drive the world around us. Every modern electronic device contains integrated circuits and nano-electronics to provide its functionality. Advances in nanotechnology directly impact society by enabling smartphones, autonomous devices, the internet of things, data storage, and essentially all forms of advanced technology.  Fabricating such nanostructures crucially depends on having the tools to make them visible without destroying them. Modern nanodevices often have complex three-di",{"id":281,"funder":7,"programme":8,"title":282,"piName":10,"institution":283,"country":32,"year":13,"amount":284,"abstract":285},"cordis-european-research-council-award-864576","Fast Radio-Labeling and Isotope Exchange","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","€1,999,431","The impact of synthetic organic molecules on health, life quality and lifestyle is beyond doubt. It is therefore of fundamental importance to detect and quantify the fate of organic compounds and provide a precise risk\u002Fbenefit assessment, before they reach the market and large public exposure. The traceless incorporation of carbon-14 allows tracking organic molecules and provides vital knowledge on their fate. This information is critical for pharmaceutical development, crop science and human fo",{"id":287,"funder":7,"programme":8,"title":288,"piName":10,"institution":283,"country":32,"year":13,"amount":289,"abstract":290},"cordis-european-research-council-award-865306","Giga-Hertz Laboratory Experiment for Axion Dark Matter","€2,112,093","The nature of the dark matter, making up most of the mass of the universe remains a mystery. The G-LEAD project aims at building an original experiment to test one of the favorite hypotheses for what dark matter could be : axions. Axions have been hypothesized in the late seventies and have been extensively searched for ever since. They elegantly solve the strong CP problem of the Standard Model and constitute a natural candidate for dark matter. Axions are expected to be very light particles an",{"id":292,"funder":7,"programme":8,"title":293,"piName":10,"institution":283,"country":32,"year":13,"amount":294,"abstract":295},"cordis-european-research-council-award-865844","Bi-Isotope 0n2b Next Generation Observatory","€2,420,370","BINGO will set the grounds for a large-scale bolometric experiment searching for neutrinoless double beta decay with a background index of about 10-5 counts\u002F(keV kg y) and with very high energy resolution – of the order of 1.5‰ – in the region of interest. These features will enable a search for lepton number violation with unprecedented sensitivity. The BINGO approach can lead to the demonstration of the Majorana nature of neutrino even in the unfavourable case of direct ordering of neutrino ma",{"id":297,"funder":7,"programme":8,"title":298,"piName":10,"institution":299,"country":53,"year":13,"amount":10,"abstract":300},"cordis-european-research-council-award-866026","Scattering-Based X-ray Imaging and Tomography","UNIVERSITA DEGLI STUDI DI TRIESTE","This research project will create new ways of doing X-ray imaging based on scattering and data redundancy. Many X-ray imaging techniques are based on simple models that fail to capture important phenomena, such as small-angle or incoherent scattering. Far from being a nuisance, scattering signals often hold valuable information on the finest structure of the investigated sample. For instance X-ray scattering can reveal fibre orientations in a carbon-fibre composite or the early formation of canc",{"id":302,"funder":7,"programme":8,"title":303,"piName":10,"institution":304,"country":87,"year":13,"amount":305,"abstract":306},"cordis-european-research-council-award-866348","Cooperative Intelligence in Swarms of Enzyme-Nanobots","FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA","€1,999,819","In nature, systems composed of self-propelling agents display complex behaviors such as signal interpretation, propagation, amplification and engage in collective motion mediated by interactions between different agents and their environment. Examples range from swarming bacteria to schooling fish and flocking birds. These self-organized systems have served as an inspiration for researchers seeking to achieve complexity in artificial systems composed of synthetic agents. A class of agents that h",{"id":308,"funder":7,"programme":8,"title":309,"piName":10,"institution":310,"country":311,"year":13,"amount":60,"abstract":312},"cordis-european-research-council-award-866480","Computational Models of Motion for Fabrication-aware Design of Bioinspired Systems","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","CH","Bridging the fields of Computer Animation and Computational Fabrication, this proposal will establish the foundations for algorithmic design of physical structures that can generate lifelike movements. Driven by embedded actuators, these types of structures will enable an abundance of possibilities for a wide array of real-world technologies: animatronic characters whose organic motions will enhance their ability to awe, entertain and educate",{"id":314,"funder":7,"programme":8,"title":315,"piName":10,"institution":316,"country":25,"year":13,"amount":317,"abstract":318},"cordis-european-research-council-award-865618","Mechanisms of Microglia Synapse Communication","DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV","€1,687,476","Microglia are the resident tissue macrophages of the brain and represent cells of the innate immune system. Looking at microglia from the immunological perspective, much is known about their role during inflammatory processes, factors that activate them and how they response e.g by releasing cytokines to mount an inflammatory response. This response has been shown to be detrimental during disease processes and lead to pruning\u002Floss of synapses, a task microglia carry out also during development. ",{"id":320,"funder":7,"programme":8,"title":321,"piName":10,"institution":322,"country":100,"year":13,"amount":323,"abstract":324},"cordis-european-research-council-award-865816","Omni-directional interferometric inertial sensor","STICHTING VU","€2,536,331","OmniSens is a novel inertial isolation system that will approach the fundamental limits imposed by materials and terrestrial gravity. Revolutionary improvements in sensitivity will come from coupling compact interferometric sensors that are beyond the state-of-the-art with a reference mass that is Omni-directionally Sensed (OmniSens). The key concept is the use of a single, geometrically-large reference mass that is sensed and softly-suspended in all six degrees of freedom, and housed within a p",{"id":326,"funder":7,"programme":8,"title":327,"piName":10,"institution":328,"country":125,"year":13,"amount":329,"abstract":330},"cordis-european-research-council-award-864724","TRUST: Towards Resilient and SUStainable ConTainer Supply Chains","LIVERPOOL JOHN MOORES UNIVERSITY","€1,989,291","Risk research represents an important challenge for the resilience and sustainability of container supply chains (CSCs). Its foci are being expanded from classical safety, through security to climate adaptation. Addressing such risks simultaneously requires integration across disciplines and research methodologies. The research community currently lacks a critical understanding of non-classical CSC risks arising from climate change, security threats (e.g. cyber-attacks), and emerging technologie",{"id":332,"funder":7,"programme":8,"title":333,"piName":10,"institution":334,"country":32,"year":13,"amount":335,"abstract":336},"cordis-european-research-council-award-864965","Predictions and Observations for Discs: Planetary Cores and dust Aggregates from non-ideal MHD Simulations with radiative Transfer.","ECOLE NORMALE SUPERIEURE DE LYON","€1,723,662","One of the most fascinating and challenging question of Modern Astrophysics is: How do planets form? Indeed, micronic dust grains must grow over 30 orders of magnitude in mass to build planet cores. Global numerical simulations of dust grains that couple the dynamics of the particles to their growth\u002Ffragmentation and the radiation in the disc are compulsory to understand this process. Yet, this coupling has never been realised, given tremendous difficulties that originate from fundamental physic",{"id":338,"funder":7,"programme":8,"title":339,"piName":10,"institution":340,"country":100,"year":13,"amount":60,"abstract":341},"cordis-european-research-council-award-863732","The mental economy: testing a dynamic trade-off between internal storage and external sampling","UNIVERSITEIT UTRECHT","While interacting with the external world, the brain can only represent very little of this world in working memory (WM). WM is therefore generally referred to as a limited-capacity system. This limitation is not a problem in daily life, however, because the external world typically remains available and can be accessed relatively easily. The current dominant theory of WM does not explain how the brain balances between internal storage and external sampling, as this theory exclusively relates to",{"id":343,"funder":7,"programme":8,"title":344,"piName":10,"institution":345,"country":346,"year":13,"amount":60,"abstract":347},"cordis-european-research-council-award-863808","Green Route to Wood-Derived Janus Particles for Stabilized Interfaces","HELSINGIN YLIOPISTO","FI","Emulsions are elemental to many aspects of every-day life, from food to pharmaceuticals. However, todays emulsion science faces a grand challenge in developing stabilizers with outstanding functionality in a sustainable manner. To enable societys transformation from oil-based economy to bioeconomy, there is an urgent need to develop sophisticated biocompatible materials, such as stabilizers of food and non-food emulsions, from biomass-derived precursors through sustainable conversion routes. Cur",{"id":349,"funder":7,"programme":8,"title":350,"piName":10,"institution":351,"country":311,"year":13,"amount":352,"abstract":353},"cordis-european-research-council-award-866345","Exploiting the DNA damage response to induce degradation of proteins","UNIVERSITAT BASEL","€1,940,756","Here I propose to use small molecules to degrade proteins specifically around sites of DNA damage by using the damage itself as a homing signal. The approach will create new ways to study DNA damage, but will also offer translational possibilities in cancer. Cancer cells are often acutely sensitive to DNA damage because they have one or more faulty DNA damage response (DDR) pathways – a feature that makes them highly dependent on their remaining DNA repair systems. We will pioneer two novel and ",{"id":355,"funder":7,"programme":8,"title":356,"piName":10,"institution":31,"country":32,"year":13,"amount":357,"abstract":358},"cordis-european-research-council-award-819179","Canonical and Non-canonical modes of Chromosome Segregation in Oocyte Meiosis","€1,561,563","Cell division is crucial for the development of complex organisms, for the homeostasis of tissues, and for the reproductive capacity of individuals. While most somatic cells are diploid and proliferate through mitosis, multiplication of sexually reproducing species relies on haploid gametes that are generated through a specialized cell division process called meiosis. To achieve this reduction in ploidy, two rounds of chromosome segregation follow a single phase of genome replication. Inaccuracy",{"id":360,"funder":7,"programme":8,"title":361,"piName":10,"institution":362,"country":25,"year":13,"amount":60,"abstract":363},"cordis-european-research-council-award-818556","Mechanisms of chromatin organization and reprogramming in totipotent mammalian zygotes","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","Totipotency, the developmental potential of a cell to give rise to all cell types, is naturally achieved when differentiated egg and sperm fuse to form the one-cell zygote. How chromatin is epigenetically reprogrammed to totipotency within hours after fertilisation remains a central question in biology. We aim to address this by investigating the mechanisms of reprogramming and the spatial reorganisation of chromatin in mammalian zygotes. Our interdisciplinary approach combines mechanistic cell ",{"id":365,"funder":7,"programme":8,"title":366,"piName":10,"institution":367,"country":125,"year":13,"amount":368,"abstract":369},"cordis-european-research-council-award-818996","Learning to remember: the development of the neural mechanisms supporting memory processing.","UNIVERSITY COLLEGE LONDON","€1,999,520","The ability to form and store memories allows organisms to learn from the past and imagine the future: it is a crucial mechanism underlying flexible and adaptive behaviour. The aim of this proposal is to identify the circuit mechanisms underlying our ability to learn and remember, by tracking the ontogenesis of memory processing. Importantly, we are not born with a fully functioning memory system: generally, adults cannot recollect any events from before their third birthday (‘infantile amnesia’",{"id":371,"funder":7,"programme":8,"title":372,"piName":10,"institution":31,"country":32,"year":13,"amount":373,"abstract":374},"cordis-european-research-council-award-863464","In-situ Topological Reduction of Scientific 3D Data","€1,998,245","Modern scientific methods heavily rely on large-scale 3D simulations. However, current data production speeds are much higher than storage speeds (5 orders of magnitude on typical supercomputers). This imbalance constitutes a major bottleneck in the scientific computing pipeline, such that most of the data generated by a simulation is not saved to disk, and thus remains unvisualized, unexplored and unanalyzed. TORI addresses this data bottleneck by introducing the next generation data reduction ",{"id":376,"funder":7,"programme":8,"title":377,"piName":10,"institution":378,"country":32,"year":13,"amount":379,"abstract":380},"cordis-european-research-council-award-864919","Real and open Gromov-Witten theory","SORBONNE UNIVERSITE","€1,351,375","This proposal focuses on establishing new relations between natural objects  in symplectic geometry with other fields of mathematics including knot and representation theory and the theory of integrable systems.  All of these relations are motivated by theoretical physics. The main objects of study are moduli spaces of pseudo-holomorphic maps giving rise to real and open Gromov-Witten invariants. The classical Gromov-Witten invariants   were introduced by Gromov  at the birth of symplectic topol",{"id":382,"funder":7,"programme":8,"title":383,"piName":10,"institution":378,"country":32,"year":13,"amount":384,"abstract":385},"cordis-european-research-council-award-864066","Corrector equations and random operators","€1,540,000","Consider a partial differential equation (PDE) with random coefficients as in engineering or applied physics: When combined with a spatial scale separation, the randomness and the differential operator interact to give rise to some effective behavior. The recent growing mathematical activity in this domain has led to a ``seemingly'' complete theory of stochastic homogenization  of linear elliptic operators. Central to this theory is the so-called corrector equation, a degenerate elliptic equatio",{"id":387,"funder":7,"programme":8,"title":388,"piName":10,"institution":389,"country":53,"year":13,"amount":390,"abstract":391},"cordis-european-research-council-award-865633","Advancing Solid Interfaces and Lubricants by First Principles Material Design","ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA","€1,403,662","Friction and wear are common phenomena that impact all applications where moving components are in contact, from micro-electromechanical systems to wind turbines, and result in massive economic and environmental costs. By advancing tribological materials impressive energy savings, and consequent reduction of CO2 emissions, can be obtained. However, in comparison with other technological applications that rely on materials, tribology is remarkably less advanced and the development of lubricants i",{"id":393,"funder":7,"programme":8,"title":394,"piName":10,"institution":389,"country":53,"year":13,"amount":10,"abstract":395},"cordis-european-research-council-award-865356","Genes, genealogies and the evolution of demographic change and social inequality","This is the first comprehensive study that combines historical and contemporaneous data to understand how population processes evolve via three interrelated channels: (1) multigenerational transmission, (2) assortative mating and (3) migration. Existing research focuses on recent factors to explain contemporaneous population trends, missing the long-view of demographic changes. As population processes (fertility and mortality) evolve slowly across generations, we urgently need to adopt a long-te",{"id":397,"funder":7,"programme":8,"title":398,"piName":10,"institution":399,"country":125,"year":13,"amount":400,"abstract":401},"cordis-european-research-council-award-865680","CHANGE. The development of the monetary economy of ancient Anatolia, c. 630-30 BC.","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€1,981,406","This project gathers, for the first time, the evidence for the development of the monetary economy of Anatolia, from the invention of coinage there in the late 7th century BC to the absorption of the region by Rome c. 30 BC. Using new digital technology, it organizes this evidence to deploy it for the first time to answer major questions concerning the economic history of this region over the longue durée.Part 1 creates a complete overview of the relevant coinages produced by c.300 cities, 4 emp",{"id":403,"funder":7,"programme":8,"title":404,"piName":10,"institution":405,"country":25,"year":13,"amount":406,"abstract":407},"cordis-european-research-council-award-866043","The Qur’an as a Source for Late Antiquity","EBERHARD KARLS UNIVERSITAET TUEBINGEN","€1,969,101","The Qur’an’s message to the populations of Mecca and Medina can only be fully understood in the context of its sustained and critical engagement with the Jewish and the Christian traditions. QaSLA complements and redevelops this approach from the ground up by utilizing the Qur’an across disciplines as witness to the history of Judaism and Christianity. Its innovation is twofold. The Qur’an, firstly, will become the primary literary source allowing us to sketch the religious landscape of the Arab",{"id":409,"funder":7,"programme":8,"title":410,"piName":10,"institution":399,"country":125,"year":13,"amount":411,"abstract":412},"cordis-european-research-council-award-864202","Better Languages for Statistics: foundations for non-parametric probabilistic programming","€1,931,178","Probabilistic programming is a powerful method for Bayesian statistical modelling, particularly where the sample space is complex or unbounded (non-parametric). This is because the statistical model can be described clearly in a way that is precise but separate from inference algorithms. It accommodates complex models in such a way that outcomes are still explainable.The objective of the proposed research is to develop a semantic foundation for probabilistic programming that properly explains th",{"id":414,"funder":7,"programme":8,"title":415,"piName":10,"institution":378,"country":32,"year":13,"amount":416,"abstract":417},"cordis-european-research-council-award-863880","TOpological many-body states with ultracold RYDberg atoms","€1,900,000","Understanding and controlling quantum matter is a key challenge for basic research and for the development of applications. The richness of quantum physics is notoriously difficult to handle for strong interactions, usually leading to massive entanglement between particles, especially when it is associated with a nontrivial topology of the Hamiltonian. The realization of well-controlled experiments probing strongly correlated quantum matter is thus a major objective to explore these perspectives",{"id":419,"funder":7,"programme":8,"title":420,"piName":10,"institution":399,"country":125,"year":13,"amount":421,"abstract":422},"cordis-european-research-council-award-864888","Targeting the Plant Cysteine Oxidases to Regulate Plant Stress Tolerance","€1,995,253","Population growth and climate change mean that food security is an emerging global challenge. Crop loss due to flood, drought and other weather extremes is something that disproportionately affects the world's poor, but also has widespread international impact. There is an immediate and urgent need to develop tools and strategies to improve crop tolerance to such abiotic stress. One effective mechanism towards this goal is molecular engineering of crops to withstand prolonged abiotic stress. Gro",{"id":424,"funder":7,"programme":8,"title":425,"piName":10,"institution":399,"country":125,"year":13,"amount":426,"abstract":427},"cordis-european-research-council-award-864828","Algebraic Foundations of Supersymmetric Quantum Field Theory","€1,963,921","A critical challenge of the current era in theoretical and mathematical physics is to understand and solve strongly coupled quantum field theories. Meeting this challenge will necessitate a significant reformulation of the edifice of quantum field theory and will surely require dramatic mathematical breakthroughs.To this end, a productive and promising strategy is to focus on the intricate algebraic structure of observables in quantum field theories, and in particular in those theories that are ",{"id":429,"funder":7,"programme":8,"title":430,"piName":10,"institution":399,"country":125,"year":13,"amount":431,"abstract":432},"cordis-european-research-council-award-865032","Sonorous Cities: Towards a Sonic Urbanism","€1,999,825","Architecture and urban design, disciplines heavily rooted in visual epistemologies, have long neglected sound, or else treated it in very limited ways: as a physical quantity that can be modelled and controlled; or else as noise, something to be reduced or eliminated. The neglect of sound on the part of the built environment professions has been damaging for cities, which suffer from poor acoustic design. As cities come under increasing scrutiny in a rapidly urbanising world, it is time to turn ",{"id":434,"funder":7,"programme":8,"title":435,"piName":10,"institution":399,"country":125,"year":13,"amount":436,"abstract":437},"cordis-european-research-council-award-864877","Deep Earth Mantle Phase Transition Maps: Studied by Time-Resolved Experiments","€2,261,100","Processes in Earth's lower mantle govern our planet's inner dynamics and control surface plate tectonics. As such, a quantitative understanding of the physical and chemical properties of the lower mantle is pivotal to model Earth’s dynamic evolution, including the long-term chemical interactions between mantle and atmosphere that are vital to the development of habitability on Earth, and possibly other planets. While seismic tomography is providing increasingly detailed three-dimensional maps of",{"id":439,"funder":7,"programme":8,"title":440,"piName":10,"institution":399,"country":125,"year":13,"amount":441,"abstract":442},"cordis-european-research-council-award-866400","Ordering, Constructing, Empowering: Fragments of the Roman Republican Antiquarians","€1,902,704","This project will radically transform our understanding of Roman Republican culture by establishing a new framework for the elaboration of knowledge and the religious and institutional structures of the Roman Republic. We will do so through the first systematic and comprehensive account of a group of Republican writers, who laid out a new way of ordering knowledge, and in the process, described the world for their contemporaries as well as for us.  This knowledge revolution re-shaped the Roman i",{"id":444,"funder":7,"programme":8,"title":445,"piName":10,"institution":31,"country":32,"year":13,"amount":446,"abstract":447},"cordis-european-research-council-award-866533","Cortical gradients of functional integration","€1,998,961","Historically, cognitive neuroscience has focused on discrete, mutually exclusive modules or networks, however, current network-level descriptions of brain organization fail to account for integrated features of cognition. I recently described a principal gradient in cortical connectivity that reflects how activity from primary sensory\u002Fmotor areas is integrated into transmodal regions of the default-mode network. This novel line of research led me to hypothesize that coherent aspects of cognition",{"id":449,"funder":7,"programme":8,"title":450,"piName":10,"institution":451,"country":87,"year":13,"amount":452,"abstract":453},"cordis-european-research-council-award-864195","Engineering catalyst interoperability in next-generation tandem reactions for intensified chemical processes","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","€1,982,188","Process intensification and catalysis are considered key stepping-stones towards a future sustainable chemical industry. Potentially, a major intensification can be achieved by the integration of two catalysts in a single reactor, to steer sequential chemical reactions in a tandem fashion. Yet, tandem catalytic processes face a notorious barrier towards industrial realization: the challenge of harmonizing the rates at which the integrated catalysts individually process and collectively exchange ",{"id":455,"funder":7,"programme":8,"title":456,"piName":10,"institution":457,"country":100,"year":13,"amount":458,"abstract":459},"cordis-european-research-council-award-865768","Advancing the Equation of state of Neutron Stars","UNIVERSITEIT VAN AMSTERDAM","€2,425,000","Densities in neutron star (NS) cores can reach up to ten times the density of a normal atomic nucleus, and the stabilising effect of gravitational confinement permits long-timescale weak interactions. This generates nucleonic matter that is extremely neutron-rich, and the exciting possibility of stable states of strange matter (hyperons or deconfined quarks). Our uncertainty about the nature of cold ultradense matter is encoded in the Equation of State (EOS), which can be mapped via the stellar ",{"id":461,"funder":7,"programme":8,"title":462,"piName":10,"institution":463,"country":464,"year":13,"amount":465,"abstract":466},"cordis-european-research-council-award-866093","Novel mechanisms of rapid perceptual learning","TEL AVIV UNIVERSITY","IL","€1,998,375","Four decades ago, studies have started pointing to sensory plasticity in the adult visual system, documenting surprising improvements in perception. Such perceptual learning is enabled by repeated practice, inducing use-dependent plasticity in early visual areas and their readouts. But is this the only route, or do other forms of more economic learning exist? My rationale is inspired by two distinct lines of evidence: reducing practice can counteract suppressive processes such as visual adaptati",{"id":468,"funder":7,"programme":8,"title":469,"piName":10,"institution":470,"country":125,"year":13,"amount":471,"abstract":472},"cordis-european-research-council-award-864921","Decoding protein persulfidation signaling","UNIVERSITY OF GLASGOW","€1,999,905","Life originally emerged and flourished in hydrogen sulfide (H2S)-rich environment and literature published in the past decade started to recognize that H2S is a mediator of many physiological and pathological processes. Exposure to H2S can put animals into suspended animation-like state while the lifespan extensions by the dietary restriction are caused by H2S accumulation. Disturbances in its production are linked to the development of neurodegenerative diseases and cancer, among many others. A",{"id":474,"funder":7,"programme":8,"title":475,"piName":10,"institution":476,"country":464,"year":13,"amount":477,"abstract":478},"cordis-european-research-council-award-864347","Personalized Interventions to Improve Intergroup Relations and Promote Peace","THE HEBREW UNIVERSITY OF JERUSALEM","€1,990,000","The recent increase in intergroup hostilities and the intertwining of local and global crises emphasizes the importance of finding ways to attenuate the destructive effects of intergroup conflicts. In recent decades, social psychologists have shown an increasing interest in offering interventions to reduce intergroup prejudice and promote intergroup reconciliation. Yet, in contrast to other scientific fields that strive towards more personalized approaches, most research on intergroup interventi",{"id":480,"funder":7,"programme":8,"title":481,"piName":10,"institution":482,"country":483,"year":13,"amount":484,"abstract":485},"cordis-european-research-council-award-864542","From East to West, and Back Again: Student Travel and Transcultural Knowledge Production in Renaissance Europe (c. 1470- c. 1620)","INSTYTUT FILOZOFII I SOCJOLOGII POLSKIEJ AKADEMII NAUK","PL","€1,737,225","This project is the first comprehensive study of transcultural knowledge production in early modern Europe. Its underpinning idea is that the students who travelled from central-eastern Europe to attend renowned universities were active agents of this transcultural knowledge. During their stays abroad they created personal hand-written notebooks containing lecture notes and any other texts that attracted their interest. Conserved in the archives of the Czech Republic, Hungary, Lithuania, Poland ",{"id":487,"funder":7,"programme":8,"title":488,"piName":10,"institution":489,"country":53,"year":13,"amount":490,"abstract":491},"cordis-european-research-council-award-865637","Flows of hot plasma connecting the Milky Way centre to the corona, halo and beyond","ISTITUTO NAZIONALE DI ASTROFISICA","€1,989,375","We are less than one year away from the beginning of a revolution in our understanding of the hot, X-ray emitting, plasma of the Milky Way. The growth of galaxies in the local Universe critically depends on the interplay (via outflows and re-condensation) between the hot plasma with the other phases of the interstellar medium (ISM). As a prototype for typical spiral galaxies, the Milky Way offers the unique opportunity to capture the important details of such feedback all the way from sub-parsec",{"id":493,"funder":7,"programme":8,"title":494,"piName":10,"institution":495,"country":496,"year":13,"amount":497,"abstract":498},"cordis-european-research-council-award-866319","The Making of Ottoman Law:  The Agency and Interaction of Diverse Groups in Lawmaking, 1450–1650","SABANCI UNIVERSITESI","TR","€1,998,785","This project investigates the formation of law in the Ottoman Empire between 1450 and 1650. Examining the religio-legal opinions (fetva) of scholars and decrees of sultans (kanun), it aims to expose the hybridity of Ottoman law by revealing the agency and interaction of diverse groups in the lawmaking process, moving beyond the well-known role of such actors as the government (the sultan and his representatives) and scholars to better understand the role of other, lesser-known actors like local ",{"id":500,"funder":7,"programme":8,"title":501,"piName":10,"institution":367,"country":125,"year":13,"amount":502,"abstract":503},"cordis-european-research-council-award-864912","Circuit and cellular mechanisms for computing spatial vectors to shelter during escape","€1,991,004","Executing actions that move the body across space to reach goals is a task that animals constantly perform. In some cases, the goal is within direct reach of sensory systems, but in others the goal location has to be retrieved from memory and requires moving towards to a memorised point in space. Previous work has identified neural circuits that represent space, and devised models for transforming object-centred spatial representations into body-centred coordinates, but we do not know the mechan",{"id":505,"funder":7,"programme":8,"title":506,"piName":10,"institution":367,"country":125,"year":13,"amount":507,"abstract":508},"cordis-european-research-council-award-863981","From parental risk to child mental illness: a genetically informed investigation of intergenerational risk pathways","€2,183,293","Mental illnesses account for 32% of years lived with disability. Critically, 50% of mental illnesses are established before age 14 years. It is thus imperative to better understand the causes of early psychiatric symptoms in childhood if we are to design effective preventive interventions. Parental risk factors e.g. psychiatric disorders and substance use have consistently emerged as strong predictors of child psychiatric symptoms. However, we do not know whether such parental risk factors are c",{"id":510,"funder":7,"programme":8,"title":511,"piName":10,"institution":512,"country":125,"year":13,"amount":513,"abstract":514},"cordis-european-research-council-award-864138","Singular Stochastic Dispersive Dynamics","THE UNIVERSITY OF EDINBURGH","€1,920,968","This proposal is concerned with the study of singular stochastic dispersive partial differential equations (PDEs), broadly interpreted, with stochastic forcing and \u002F or random initial data. This is a young emerging field, attracting more and more attention. In recent years, we have witnessed outstanding advances in the theory of singular stochastic parabolic PDEs. Our understanding of the dispersive counterpart is, however, much poorer. The main objective of this proposal is to develop novel mat",{"id":516,"funder":7,"programme":8,"title":517,"piName":10,"institution":518,"country":87,"year":13,"amount":519,"abstract":520},"cordis-european-research-council-award-865157","Deconstructing the Translational Control of Myelination by Specialized Ribosomes","UNIVERSIDAD DE SANTIAGO DE COMPOSTELA","€1,874,996","The myelin sheath is essential for neuronal function and health: myelinating glial cells speed up propagation of axonal potentials, fuel the energetic demands and regulate the ionic environment of neurons. Lesions to the myelin sheath thus result in devastating neurological disorders that include multiple sclerosis, diabetic neuropathy and Charcot-Marie-Tooth disease. Myelination involves a striking expansion of the glial cell membrane that relies on an exceptional increase in protein and lipid ",{"id":522,"funder":7,"programme":8,"title":523,"piName":10,"institution":524,"country":125,"year":13,"amount":525,"abstract":526},"cordis-european-research-council-award-865075","Solving gauge theories in 4D: Exact correlation functions from integrability","KING'S COLLEGE LONDON","€1,922,232","Our current fundamental understanding of the world is through the Standard Model, which is based on gauge theory. But conventional computational tools are either bound to the weakly coupled regime or have rather limited precision.This project is built upon the unique and novel fundamental structure I found, called the Quantum Spectral Curve. It is based on integrability, and allows one to get exact results in an important class of gauge theories at finite values of the coupling. Using the Quantu",{"id":528,"funder":7,"programme":8,"title":529,"piName":10,"institution":340,"country":100,"year":13,"amount":530,"abstract":531},"cordis-european-research-council-award-864137","Understanding and Unleashing Adolescents' Eco-Friendly Behavior","€1,999,349","The world faces an unprecedented environmental crisis, and human activity is its root cause. This poses a call to action for psychology and the social sciences more broadly. GREENTEENS proposes that our adolescents—a segment of the population whose collective behavior will shape the future of the planet—can play a vital role in creating a more sustainable world. Adolescents, however, are “closet idealists”: As a group, they care about the environment but often fail to act on their concerns. The ",{"id":533,"funder":7,"programme":8,"title":534,"piName":10,"institution":535,"country":311,"year":13,"amount":60,"abstract":536},"cordis-european-research-council-award-864042","Low-latency Perception and Action for Agile Vision-based Flight","UNIVERSITAT ZURICH","Drones are disrupting industries, such as agriculture, package delivery, inspection, and search and rescue. However, they are still either controlled by a human pilot or heavily rely on GPS for navigating autonomously. The alternative to GPS are onboard sensors, such as cameras: from the raw data, a local 3D map of the environment is built, which is then used to plan a safe trajectory to the goal. While the underlying algorithms are well understood, we are still far from having autonomous drones",{"id":538,"funder":7,"programme":8,"title":539,"piName":10,"institution":540,"country":87,"year":13,"amount":541,"abstract":542},"cordis-european-research-council-award-866018","Low dimensional semiconductors for optically tuneable solar harvesters","UNIVERSITAT POLITECNICA DE CATALUNYA","€1,994,375","SENSATE proposes ground breaking ideas and concepts combining very innovative low dimensional thin film materials and highly asymmetric selective contacts with dipoles, for the development of non-intrusive and universal solar energy harvester. Materials, processes and devices design innovations will be combined in a straightforward manner, in order to develop next generation of cost-efficient and highly-stable\u002Foptically-tuneable photovoltaic (PV) devices.For achieving this, SENSATE proposes expl",{"id":544,"funder":7,"programme":8,"title":545,"piName":10,"institution":546,"country":25,"year":13,"amount":47,"abstract":547},"cordis-european-research-council-award-865119","Protein phosphatase 1-disrupting peptides: Scope and mechanism of action in the treatment of heart insufficiency","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","Protein phosphatase-1 (PP1) is a ubiquitously expressed enzyme known to dephosphorylate a large number of the phosphorylated serines and threonines. The catalytic subunit PP1c is bound to regulatory proteins in holoenzymes. These play specific and fundamental roles in physiological processes and pathologies. One key role lies in the regulation of important cardiac signaling pathways and calcium homoeostasis. Accordingly, deregulation of PP1 has been implicated in cardiac dysfunctions. Powerful t",{"id":549,"funder":7,"programme":8,"title":550,"piName":10,"institution":551,"country":552,"year":13,"amount":553,"abstract":554},"cordis-european-research-council-award-865985","Chemical Engineering of Fused MetalloPorphyrins Thin Films for the Clean Production of Hydrogen","LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY","LU","€1,900,711","This project stands in the general context of the current worldwide energy and environmental crisis. It aims to engineer a new generation of conjugated microporous polymers based on fused metalloporphyrins for the low-cost, clean and efficient production of hydrogen from solar water splitting. The CLEANH2 concept relies on the gas phase reaction of metalloporphyrins to engineer new heterogeneous catalysts with remarkable hydrogen production yields. Metalloporphyrins, selected by Nature to fulfil",{"id":556,"funder":7,"programme":8,"title":557,"piName":10,"institution":558,"country":25,"year":13,"amount":60,"abstract":559},"cordis-european-research-council-award-864482","Structural multiscale modelling of extrusion-based 3D and 4D printed materials","UNIVERSITAET DER BUNDESWEHR MUENCHEN","Fused Deposition Modelling (FDM) is a common 3D printing technology based on the extrusion of thermoplastic filaments. While it was initially used only for prototyping, it is nowadays shifting towards manufacturing of mechanical components. 4D printing is a very novel technology to produce smart materials and structures through 3D printing of shape memory materials. Due to the specific process of FDM, the material obtains a characteristic mesostructure, which can be controlled through the print ",{"id":561,"funder":7,"programme":8,"title":562,"piName":10,"institution":563,"country":25,"year":13,"amount":564,"abstract":565},"cordis-european-research-council-award-864669","Energizing microbes with redox mediators for new bioproductions","LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-INSTITUT","€1,999,991","In many bioprocesses a broad bioproduct portfolio can currently only be obtained when microorganisms can access oxygen as an electron acceptor. For numerous target substances, however, oxygen is detrimental to product stability and the bioprocess operation. The central aim of e-MICROBe is to innately couple microbial metabolism and electrochemistry via a self-secreted soluble electron mediator to achieve efficient oxygen independent energy metabolism and to directly steer and control metabolism ",{"id":567,"funder":7,"programme":8,"title":568,"piName":10,"institution":569,"country":25,"year":13,"amount":60,"abstract":570},"cordis-european-research-council-award-866051","Pulmonary hypertension: “aberrant” mimicry of lung vascular morphogenesis?","JUSTUS-LIEBIG-UNIVERSITAET GIESSEN","Chronic pulmonary hypertension (PH) is a lethal disease characterized by the accumulation of persistently activated cell types in the pulmonary vasculature, exhibiting aberrant expression of genes driving apoptosis resistance, proliferation, inflammation and matrix remodeling. Current vasodilatory therapies for PH do not normalize these activated phenotypes. I have performed an “integromics” approach – combining epigenetic and transcriptional analyses to comprehensively elucidate the underlying ",{"id":572,"funder":7,"programme":8,"title":573,"piName":10,"institution":367,"country":125,"year":13,"amount":574,"abstract":575},"cordis-european-research-council-award-864420","The Neurocognition of Liveness","€1,927,120","What makes live experiences special? Liveness is not just central to the performing arts, but to political rallies, sporting events, virtual reality and distance learning in higher education. NEUROLIVE is an inherently interdisciplinary research project, that combines theoretical concepts from theatre and performance studies, artistic research in performance making, psychological experimentation and mobile neuroimaging to understand how liveness is generated and experienced. NEUROLIVE proposes t",{"id":577,"funder":7,"programme":8,"title":578,"piName":10,"institution":457,"country":100,"year":13,"amount":60,"abstract":579},"cordis-european-research-council-award-864145","Zeta functions and Fourier-Mukai transforms","Arithmetic geometry and the study of derived categories of coherent sheaves are two central areas of research in algebraic geometry. Despite their many points of contact, they have until recently remained largely disjoint. The zeta function of an algebraic variety over a finite field is one of the most studied invariants in arithmetic geometry, and a conjecture of Orlov predicts that this invariant can be detected by the derived category of coherent sheaves on the variety. In this project, I wil",{"id":581,"funder":7,"programme":8,"title":582,"piName":10,"institution":583,"country":25,"year":13,"amount":584,"abstract":585},"cordis-european-research-council-award-865466","Spatio-Temporal Regulation of Inflammation and Tissue Regeneration: Studying the immune system - tissue - microbiota communication to develop targeted therapies for immune-mediated diseases and cancer","UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF","€1,999,687","Inflammation is fundamental to promote tissue regeneration upon injury, and in turn, the resolution of the immune response. Physiological tissue regeneration depends on fine-tuned interaction between the immune system, the tissue, and the microbiota. However, the complex communication between these three components and the molecules that mediate it are unclear. Understanding this is fundamental to prevent immune-mediated diseases and even cancer. This is particularly important at mucosal surface",{"id":587,"funder":7,"programme":8,"title":588,"piName":10,"institution":345,"country":346,"year":13,"amount":589,"abstract":590},"cordis-european-research-council-award-864358","Animals Make identities. The Social Bioarchaeology of Late Mesolithic and Early Neolithic Cemeteries in North-East Europe","€1,992,839","AMI aims to provide a novel interpretation of social links between humans and animals in hunter-gatherer cemeteries in North-East Europe, c. 9000–7500 years ago. AMI brings together cutting-edge developments in bioarchaeological science and the latest understanding of how people’s identities form in order to study the relationships between humans and animals. Grave materials and human remains will be studied from the viewpoint of process rather than as isolated objects, and will be interpreted t",{"id":592,"funder":7,"programme":8,"title":593,"piName":10,"institution":594,"country":25,"year":13,"amount":60,"abstract":595},"cordis-european-research-council-award-864246","(Photo-)Control of Persisters: Targeting the Magic Spot","ALBERT-LUDWIGS-UNIVERSITAET FREIBURG","The abusive use of antibiotics has led to multidrug-resistant bacteria and the acute threat of a post-antibiotic era. However, apart from resisters, there is a subgroup of bacteria called persisters that surviveby recalcitrance to antibiotic treatment. Persisters are not resistant to antibiotics but simply survive by metabolic shutdown. Upon withdrawal of antibiotics, these persisters resuscitate and regenerate the colony. They are heavily involved in failure of antibiotic treatment and the deve",{"id":597,"funder":7,"programme":8,"title":598,"piName":10,"institution":599,"country":600,"year":13,"amount":601,"abstract":602},"cordis-european-research-council-award-864483","Novel Oxides and Topological Interfaces for quantum Computing Electronics","INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM","BE","€2,332,691","Todays quantum computers are suffering from a very high error rate due to decoherence (i.e. loss of quantum information) in their qubits fabricated with superconductors junctions or semiconductors quantum dots. The goal of this proposal is to research radically new materials and architectures to build a fault-tolerant qubit device on Silicon substrate (i.e. scalable), that will be immune to decoherence problems.In NOTICE, we will design and synthetize novel crystalline perovskite materials, mono",{"id":604,"funder":7,"programme":8,"title":605,"piName":10,"institution":606,"country":100,"year":13,"amount":60,"abstract":607},"cordis-european-research-council-award-865175","New Reagents for Quantifying the Routing and Kinetics of T-cell Activation","UNIVERSITEIT LEIDEN","The activation of The activation of cytotoxic T-cells (CTLs) marks the key step in the adaptive immune response against cancer and viral infections. Vaccines that activate the CTL-response against tumours are currently hotly pursued, with those targeting tumour-specific mutations now reaching the clinic. However, the capacity of these vaccines to actually activate CTLs is low and rational design improvements are needed to broaden their application. For this, better in vivo knowledge on the proce",{"id":609,"funder":7,"programme":8,"title":610,"piName":10,"institution":611,"country":612,"year":13,"amount":613,"abstract":614},"cordis-european-research-council-award-865849","Controlling Activity of Lysogenic Phages by Small Molecule Inducers and Dysregulators","UNIVERSITAT WIEN","AT","€1,992,240","The human microbiome has been increasingly in the focus of research for its importance in human health and disease. Yet, the viruses (phages) infecting these microbiota have gained much less attention. The majority of phages reside integrated in the genomes of their microbial hosts as so called lysogenic prophages. Often, these prophages encode important toxins and other virulence related factors that, while they are beneficial to their microbial hosts, may be detrimental for the infected human.",{"id":616,"funder":7,"programme":8,"title":617,"piName":10,"institution":618,"country":464,"year":13,"amount":60,"abstract":619},"cordis-european-research-council-award-865932","The origins of thermonuclear supernova explosions","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","Type-Ia supernovae (SNe) are thought to originate from thermonuclear explosions of carbon-oxygen (CO) white-dwarfs (WDs). They play a key role in the evolution of the universe (producing most of the Iron-peak elements); and serve as critical cosmological distance-indicators. The main proposed SNe progenitors are CO-WDs accreting material from stellar companions; and mergers of two CO-WDs. However, all suggested models fail to reproduce the diverse physical characteristics of Ia-SNe; their inferr",{"id":621,"funder":7,"programme":8,"title":622,"piName":10,"institution":623,"country":311,"year":13,"amount":624,"abstract":625},"cordis-european-research-council-award-864672","Evolutionary Consequences of Arrested Genomic Conflict in Asexual Species","UNIVERSITE DE LAUSANNE","€1,989,769","Genomic conflicts are major drivers of evolutionary innovation and play an increasingly recognized role in human disease. Intra-genomic conflicts arise because self-promoting elements such as driving centromeres or transposable elements (TEs) can spread in a population without increasing the fitness of their carriers. Inter-genomic conflicts arise when genes have opposite fitness effects in different carriers, as is the case for genes underlying traits with distinct optimal values in males and f",{"id":627,"funder":7,"programme":8,"title":628,"piName":10,"institution":629,"country":25,"year":13,"amount":630,"abstract":631},"cordis-european-research-council-award-866537","Collective signaling oscillations in embryonic patterning –  revealing underlying principles","EUROPEAN MOLECULAR BIOLOGY LABORATORY","€2,153,310","In this proposal, we study collective signaling oscillations during embryonic patterning. Signaling oscillations during vertebrate embryo segmentation are governed by a molecular oscillatory machinery referred to as segmentation clock (Palmeirim et al., 1997). The segmentation clock is linked to periodic activity of the Notch, Wnt and Fgf pathway in presomitic mesoderm (PSM) cells (period~2 hours in mouse embryos). Importantly, PSM cells display complex, collective synchronization and, as a resu",{"id":633,"funder":7,"programme":8,"title":634,"piName":10,"institution":124,"country":125,"year":13,"amount":635,"abstract":636},"cordis-european-research-council-award-866028","Model-guided Engineering of Complex Microbial Communities","€1,995,818","Microbial communities occupy practically all habitats on Earth, from ocean deeps to the human gut, and are pivotal to the ecosystem function. They also hold a vast biotechnological potential to realize functionalities typically beyond the reach of single species, e.g. valorisation of complex resources. Rational design and modulation of communities can thus help addressing outstanding challenges in health and bio-sustainability. Yet, this remains difficult due to the complexity of interspecies in",{"id":638,"funder":7,"programme":8,"title":639,"piName":10,"institution":640,"country":346,"year":13,"amount":641,"abstract":642},"cordis-european-research-council-award-866435","Learning Pixel-Perfect 3D Vision and Generative Modeling","AALTO KORKEAKOULUSAATIO SR","€1,858,013","A fascinating tension exists between computer vision and computer graphics. Decades of research efforts have led to the  ability of graphics algorithms to simulate the world to a degree often indistinguishable from reality -- given an accurate enough model of scene geometry and appearance. Similarly, decades of ingenuity have given computer vision techniques the already, at times, superhuman capability of detecting, recognizing, and predicting objects, actions, and identities from pictures or vi",{"id":644,"funder":7,"programme":8,"title":645,"piName":10,"institution":646,"country":464,"year":13,"amount":60,"abstract":647},"cordis-european-research-council-award-864127","Attosecond Gated Holography","WEIZMANN INSTITUTE OF SCIENCE","Strong-field-driven electric currents in condensed-matter systems open new frontiers in manipulating electronic and optical properties on petahertz frequency scales. In this regime, new challenges arise as the role of the band structure and the quantum nature of ultrafast electron-hole dynamics have yet to be resolved. While petahertz spectroscopy and control of condensed-matter systems holds great potential, revealing the underlying attosecond (1 attosecond – 10(-18)  second) dynamics of electr",{"id":649,"funder":7,"programme":8,"title":650,"piName":10,"institution":651,"country":25,"year":13,"amount":652,"abstract":653},"cordis-european-research-council-award-862367","Sound Knowledge: Alternative Epistemologies of Music in the Western Pacific Island World","GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS","€1,964,136","SoundKnowledge aims to rethink, for the first time, music in terms of the procedural knowledge inherent in and specific to music-making by exploring music-making as knowledge practices in Micronesia, Western Pacific Island world. This knowledge, formed in the performance of musical practice, may prove to be key to survival in the complex postcolonial predicament of Micronesia. I will address the issues of climate change, social alienation and postcolonial trauma in specific parts of Micronesia b",{"id":655,"funder":7,"programme":8,"title":656,"piName":10,"institution":657,"country":12,"year":13,"amount":658,"abstract":659},"cordis-european-research-council-award-865870","Challenging The Limits Of Molecular Quantum Interference Effects","KOBENHAVNS UNIVERSITET","€1,999,468","Over the last ten years, there has been a growing interest in quantum interference effects observed in molecules. Remarkably, given their fragility in mesoscopic physics, molecular quantum interference effects can be readily observed at room temperature in solution. This robustness comes from the extremely small size of the molecular components (1-2nm) and thereby the small dimensions over which phase coherence is required.   The aim of this project is to challenge the limits of molecular quantu",{"id":661,"funder":7,"programme":8,"title":662,"piName":10,"institution":463,"country":464,"year":13,"amount":663,"abstract":664},"cordis-european-research-council-award-864353","Sleep and episodic memory consolidation:  ‘No-report’ paradigms, brain mechanisms, and dementia","€2,745,000","Episodic memory is a core element of the human mind, but how experiencing an episode consolidates into long-term memory remains a central unsolved question in cognitive science. We will test the hypothesis that hippocampal-cortical dialogue (HCD) during sleep promotes memory consolidation, a hypothesis that has been largely beyond direct testing in humans to date. Moreover, transcending report is essential, since it remains unclear if sleep improves memory per-se, or the ability to access and re",{"id":666,"funder":7,"programme":8,"title":667,"piName":10,"institution":668,"country":25,"year":13,"amount":669,"abstract":670},"cordis-european-research-council-award-863393","Archipelagic Imperatives: Shipwreck and Lifesaving in European Societies since 1800","GEISTESWISSENSCHAFTLICHE ZENTREN BERLIN EV","€1,912,016","Why does humanitarianism take the form of an archipelago, an aggregation of single issues, selective, resistant to generalization, and even at times inconsistent? In order to answer this question, which is crucial to, but has been sidelined in histories of humanitarianism, the project develops a novel approach. This approach homes in on the rupture of humanitarian morality with quotidian moral norms and values.For this purpose, the project investigates the history of a particular moral norm, the",{"id":672,"funder":7,"programme":8,"title":673,"piName":10,"institution":674,"country":25,"year":13,"amount":675,"abstract":676},"cordis-european-research-council-award-865877","Next-generation Plasma-based Electron Beam Sources  for High-brightness Photon Science","HEINRICH-HEINE-UNIVERSITAET DUESSELDORF","€2,059,493","High-quality electron beams are required for advanced light sources and for high energy physics. Engines of discovery such as free-electron-lasers (FELs) and other bright light sources, are driven by electron beams today produced in km-long state-of-the-art linear accelerators (linacs). A complementary alternative are cm-scale plasma-based accelerators, which are feasible in university-lab scale environments. The NeXource project aims at combining key advantages of both types of accelerators to ",{"id":678,"funder":7,"programme":8,"title":679,"piName":10,"institution":606,"country":100,"year":13,"amount":680,"abstract":681},"cordis-european-research-council-award-864635","FEATHERS (FE \u002F MALES AND THEIR SCRIBES): Authorship and the Mediation of Voices, c. 1558-1642","€1,999,996","When we look at a text, we think we know who wrote it. Indeed, Paradise Lost was authored by John Milton; the warrant of execution for Mary, Queen of Scots by Elizabeth I. The writers of these texts, the pen wielders, however, were Deborah Milton, and W. Davidson with Burghley. Manuscript production was a collaborative or ‘socialised’ enterprise that often involved secretaries and scribes who physically wrote what the author dictated.Sometimes, however, they contributed rather more. Google, MS W",{"id":683,"funder":7,"programme":8,"title":684,"piName":10,"institution":340,"country":100,"year":13,"amount":685,"abstract":686},"cordis-european-research-council-award-864528","Physiologically Crowded Artificial Cells for Relevant Drug Screens","€1,994,956","In the crowded cell, nonspecific interactions between biomolecules alter biochemical equilibria. This matrix of weak nonspecific interactions is composed of hydrophobic, electrostatic, H-bonding, van der Waals, and steric interactions, and is the dark matter of biology.Inaccurate prediction of the behaviour of biomolecules inside cells hampers drug discovery: A high throughput drug screen against a purified target protein in dilute buffer ignores the presence of these weak interactions and resul",{"id":688,"funder":7,"programme":8,"title":689,"piName":10,"institution":690,"country":94,"year":13,"amount":691,"abstract":692},"cordis-european-research-council-award-864182","Protecting the Right to Culture of Persons with Disabilities and Enhancing Cultural Diversity through European Union Law: Exploring New Paths","NATIONAL UNIVERSITY OF IRELAND MAYNOOTH","€1,999,337","The right of people with disabilities to participate in cultural life - which encompasses the rights of access to, and to be involved in cultural activities, as well as the recognition of disability identities, such as Deaf culture – has been for long denied. The cultural exclusion of disabled people has engendered their marginalisation. It has also entailed a loss for society as a whole, because of the lack of cultural diversity resulting from an inaccessible and exclusionary cultural realm. DA",{"id":694,"funder":7,"programme":8,"title":695,"piName":10,"institution":696,"country":25,"year":13,"amount":697,"abstract":698},"cordis-european-research-council-award-863823","MAcroscopic quantum Transport maTERials by nanoparticle processing","UNIVERSITAET DUISBURG-ESSEN","€1,999,664","Ever since the discovery of topological surface states in three-dimensional (3D) topological insulators (TI), this fascinating physics has thrilled scientists. While arguable the transport properties of 3D TIs are of utmost importance for potential applications, they are extremely difficult to characterize, yet utilize for devices. The reason is that transport in those materials is always dominated by bulk carriers. Within this proposed research project, I will overcome the problem of bulk carri",{"id":700,"funder":7,"programme":8,"title":701,"piName":10,"institution":702,"country":612,"year":13,"amount":60,"abstract":703},"cordis-european-research-council-award-863839","Acoustics-based drone navigation and interaction","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","Autonomous multi-rotor aerial vehicles (MAVs) are an emerging technology, which has a large number of current and potential applications in a wide range of industries. These airborne vehicles are becoming growingly autonomous thanks to modern artificial intelligence technologies, with their navigation and interaction capabilities based predominantly on visual sensing. While vision navigation has attracted considerable attention, it suffers from a poor performance in low light, limited field of v",{"id":705,"funder":7,"programme":8,"title":706,"piName":10,"institution":707,"country":25,"year":13,"amount":10,"abstract":708},"cordis-european-research-council-award-865077","Major depression as a metabolic disorder: The role of oxygen homeostasis and mitochondrial bioenergetics in depression etiology and therapy","UNIVERSITAET ULM","MitO2Health aims to develop and empirically prove a radically new pathophysiological model of Major Depressive Disorder (MDD) as a systemic energy deficiency disease. Traditionally, MDD is conceptualized as a neurotransmitter deficiency in the brain. However, with pioneering methods my group has provided evi-dence for reduced mitochondrial energy production in MDD, characterizing it as a cellular-metabolic disorder with a lowered production of adenosine triphosphate (ATP). Reduced mitochondrial ",{"id":710,"funder":7,"programme":8,"title":711,"piName":10,"institution":712,"country":713,"year":13,"amount":714,"abstract":715},"cordis-european-research-council-award-864189","Music at the Frontiers of Artificial Creativity and Criticism","KUNGLIGA TEKNISKA HOEGSKOLAN","SE","€1,997,918","Artificial intelligence (AI) is an especially disruptive technology, impacting a growing number of domains in ways both beneficial and detrimental. It is even showing surprising impacts in the Arts, provoking questions fundamental to philosophy, law, and engineering, not to mention practices in the Arts themselves. MUSAiC is an interdisciplinary research venture confronting questions and challenges at the frontier of the AI disruption of music. It aims to analyze, criticize and fundamentally bro",{"id":717,"funder":7,"programme":8,"title":718,"piName":10,"institution":719,"country":720,"year":13,"amount":60,"abstract":721},"cordis-european-research-council-award-863955","Mechanical Biomarkers for Prediction of Cancer Immunotherapy","UNIVERSITY OF CYPRUS","CY","Immunotherapy has revolutionized the treatment of multiple cancers and has already become a standard of care for some tumor types. However, a majority of patients do not benefit from current immunotherapeutics and many develop severe toxicities. Therefore, the identification of biomarkers to classify patients as likely responders or nonresponders to immunotherapy is a timely and of tremendous impact task. My hypothesis is that biomechanical aspects of the tumor microenvironment mediate resistanc",{"id":723,"funder":7,"programme":8,"title":724,"piName":10,"institution":725,"country":87,"year":13,"amount":726,"abstract":727},"cordis-european-research-council-award-864759","Metastasis-associated altered molecular patterns in the brain","FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III","€1,897,437","Organ colonization is the most inefficient step of metastasis. However, once a few cancer cells manage to re-initiate their growth in the brain, the initial naïve microenvironment, which was not favouring and even actively limiting the number of potential metastasis initiating cells, is slowly rewired into a different ecosystem with pro-metastatic properties. In this project (ALTER-brain), we will study the biology of microenvironment reprogramming to explore innovative ways of treating metastas",{"id":729,"funder":7,"programme":8,"title":730,"piName":10,"institution":731,"country":100,"year":13,"amount":60,"abstract":732},"cordis-european-research-council-award-864180","Quantifying the spread of P. falciparum malaria","STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM","Background: A major challenge for malaria elimination is its phenomenally efficient spread through sexual stage parasites (gametocytes). Many individuals in endemic settings harbour low but transmissible gametocyte densities. It is currently unclear how gametocyte density translates into the likelihood that an infected mosquito gives rise to secondary infections, who drive malaria transmission at population level and how anti-gametocyte immunity affects gametocyte production and infectivity. I h",{"id":734,"funder":7,"programme":8,"title":735,"piName":10,"institution":736,"country":600,"year":13,"amount":60,"abstract":737},"cordis-european-research-council-award-864311","Disentangling the stringent response to engineer novel anti-persister drugs","UNIVERSITE LIBRE DE BRUXELLES","Bacterial “superbugs”, refringent to antibiotic treatments, have rapidly increased with the turn of the century. Slow growing, dormant cells (known as persisters) are subpopulations of bacteria that tolerate antibiotics and are considered a primary source of infections for antibiotic-resistant pathogens since they are difficult to eradicate in conventional ways. Mutations in RelA\u002FSpoT (RSH), the effectors of the stringent response, promote antibiotic tolerance and persistent infections and are c",{"id":739,"funder":7,"programme":8,"title":740,"piName":10,"institution":741,"country":125,"year":13,"amount":742,"abstract":743},"cordis-european-research-council-award-863944","Thinking Deep-Novel Creative Approaches to the Underground","ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE","€1,940,685","THINK DEEP pioneers a creative practice driven interdisciplinary approach to the underground.It begins from the dual premise that, firstly the underground (or subterranean) is both the site of current environmental concerns (e.g. extraction), and the setting for developing solutions to these concerns. But that secondly, currently we lack approaches that adequately understand the underground, its current use and conservation, and its future possibilities. Underground scholars have long argued tha",{"id":745,"funder":7,"programme":8,"title":746,"piName":10,"institution":747,"country":125,"year":13,"amount":748,"abstract":749},"cordis-european-research-council-award-866155","Towards a Third Nuclear Age? Strategic Conventional Weapons and the Next Revolution in Global Nuclear Order","UNIVERSITY OF LEICESTER","€1,642,826","The world stands on the cusp of a major transformation in nuclear affairs. This paradigmatic shift is being driven by the development and deployment of an entirely new class of strategic weaponry, facilitated by the latest information revolution. The most important characteristics of these weapons are that they are all hi-tech and non-nuclear; that they can be used against an adversarys nuclear forces, and that they are increasingly able to augment and even replace nuclear weapons for key nation",{"id":751,"funder":7,"programme":8,"title":752,"piName":10,"institution":657,"country":12,"year":13,"amount":753,"abstract":754},"cordis-european-research-council-award-863671","IN THE SAME SEA: THE LESSER ANTILLES AS A COMMON WORLD OF SLAVERY AND FREEDOM","€1,999,970","IN THE SAME SEA is the first systematic investigation of the combined history of the Lesser Antilles from the 1650s to the 1850s.The project advances the hypothesis that the Lesser Antilles were decisively shaped by inter-island connections that transformed separate islands into a common world of slavery and freedom. Living in fragile societies of limited resources and marked by racial slavery, plantation production, and long-distance commerce, enslaved Africans, free people of color, and Europe",{"id":756,"funder":7,"programme":8,"title":757,"piName":10,"institution":758,"country":311,"year":13,"amount":10,"abstract":759},"cordis-european-research-council-award-864498","Revamping Anticorruption Criminal Law – Strategies and Consequences","UNIVERSITE DE NEUCHATEL","Fighting transnational corporate corruption is today a global task, resulting in an increase in criminalisation. However, when it comes to law enforcement, prosecutors face major problems: fact-finding is hampered and gathering evidence from foreign jurisdictions by way of traditional mutual legal assistance is arduous, if not impossible. Despite these major difficulties, since 2000 the enforcement of anti-corruption norms has flourished, resulting in multi-jurisdictional criminal procedures. Th",{"id":761,"funder":7,"programme":8,"title":762,"piName":10,"institution":340,"country":100,"year":13,"amount":60,"abstract":763},"cordis-european-research-council-award-865468","Coming-of-age of Process Research: Connecting Theory with Measurement and Modelling","Recent innovations in measurement such as ambulatory assessments and experience sampling, have created the unique opportunity to study psychological processes as they unfold over time in everyday life. Combined with novel statistical models that focus on within-person dynamics, these developments offer a radically new perspective on foundational concepts in psychology. In clinical psychology for instance, these innovations are used to study mental disorders as networks of symptoms that trigger e",{"id":765,"funder":7,"programme":8,"title":766,"piName":10,"institution":611,"country":612,"year":13,"amount":767,"abstract":768},"cordis-european-research-council-award-863476","Symmetries and Entanglement in Quantum Matter","€1,953,375","Symmetries are at the heart of quantum many-body phenomena in quantum chemistry, condensed matter, and high energy physics. They govern the structure of physical laws, and explain different phases through the mechanism of symmetry breaking. The discovery of novel unconventional phases such as the fractional quantum Hall effect has challenged this view: These phases instead display a global ordering in their entanglement, hindering a characterization in terms of local symmetries.The goal of my pr",{"id":770,"funder":7,"programme":8,"title":771,"piName":10,"institution":524,"country":125,"year":13,"amount":772,"abstract":773},"cordis-european-research-council-award-863869","Single Molecule Imaging-based design of HIV-1 vaccines","€2,280,390","The HIV-1 vaccine research has re-emerged in the last few years due to the identification of antibodies that neutralize most HIV-1 circulating strains. A deeper understanding of the mechanistic mode of target recognition for these antibodies represents a big hope in the field. This project aims at understanding and characterizing polyclonal antibody responses to aid rational vaccine design via radically new technologies on light microscopy. The molecular mechanism of time-resolved HIV-1 fusion w",{"id":775,"funder":7,"programme":8,"title":776,"piName":10,"institution":518,"country":87,"year":13,"amount":777,"abstract":778},"cordis-european-research-council-award-863914","Bimetallic Catalysis for Diverse Methane Functionalization","€1,999,679","One of the remaining primary challenges in modern chemistry is the development of clean, energy- and cost-efficient catalytic processes that can allow to convert simple and abundant chemical feedstocks into high value-added products. Given the vast reserves of methane from natural gas, available worldwide, the direct use of the simplest alkane as source of fuels and chemicals could have a great impact in our society. However, methane´s low intrinsic reactivity has rendered its use extremely diff",{"id":780,"funder":7,"programme":8,"title":781,"piName":10,"institution":782,"country":25,"year":13,"amount":783,"abstract":784},"cordis-european-research-council-award-865634","Molecular mechanisms of presynaptic plasticity","UNIVERSITAET LEIPZIG","€1,609,937","The ambitious goal of this project is to reveal the molecular mechanisms of presynaptic plasticity in the vertebrate brain. Synaptic plasticity occurs in the form of alterations in both presynaptic neurotransmitter release and postsynaptic receptor function. However, due to technical reasons and in contrast to intensely studied postsynaptic plasticity, the presynaptic half of the brain’s synaptic plasticity remains enigmatic. This is a crucial knowledge gap for our understanding of learning and ",{"id":786,"funder":7,"programme":8,"title":787,"piName":10,"institution":788,"country":713,"year":13,"amount":789,"abstract":790},"cordis-european-research-council-award-866075","Autoantibodies and chronic pain -  Unraveling new mechanisms contributing to pain in rheumatic disease","KAROLINSKA INSTITUTET","€1,993,763","Pain is one of the most problematic symptoms of rheumatic disease such as rheumatoid arthritis (RA) and fibromyalgia (FM). We have earlier discovered that antibodies (immunoglobulin, IgG) purified from blood of seropositive rheumatoid arthritis (RA) patients induce pain-like behavior when transferred to mice, independent of inflammatory reactions. Even though FM is not considered an autoimmune disease, it has been suggested that neuroimmune dysregulation contribute to the pathogenesis. Therefore",{"id":792,"funder":7,"programme":8,"title":793,"piName":10,"institution":794,"country":612,"year":13,"amount":795,"abstract":796},"cordis-european-research-council-award-864628","Evolving Single-Atom Catalysis: Fundamental Insights for Rational Design","TECHNISCHE UNIVERSITAET WIEN","€1,993,718","Rare and expensive metals tend to be the best catalysts, and minimising or replacing them is a major research target as we strive to develop an economy based on more environmentally-friendly, energy-efficient technologies. Single-atom catalysis (SAC) represents the ultimate in efficiency, and the chemical bonds formed between the metal atom and the support mean these systems strongly resemble the organometallic complexes utilized in homogeneous catalysis. If all active sites were identical, sing",{"id":798,"funder":7,"programme":8,"title":799,"piName":10,"institution":340,"country":100,"year":13,"amount":60,"abstract":800},"cordis-european-research-council-award-865165","The Business Corporation as a Political Actor","Business corporations exercise political power, both internally (towards their employees) and externally (towards states, consumers and others). However, corporations have often fallen from the radar in the dominant theories of legitimacy in political philosophy\u002Fpolitical theory, i.e. the social contract tradition. The latter has been wedded since the Westphalian era to an individual\u002Fstate dualism in which there is no evident place for intermediate associations. The dominance of economic theorie",{"id":802,"funder":7,"programme":8,"title":803,"piName":10,"institution":804,"country":25,"year":13,"amount":10,"abstract":805},"cordis-european-research-council-award-865463","Cultural diversity in the Middle Nile Valley. Reconstructing biographies in the periphery of urban centres in northern Sudan during the Bronze Age","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","One of the biggest scientific challenges for archaeology is to move away from established concepts of cultural categories such as static views of culture, which are not suitable to describe realities of ancient lives. Significant work on the complex encounters between Egyptian and Nubian groups in the Middle Nile was conducted by recent projects including my ERC-2012-StG AcrossBorders. They introduced the modern approach of cultural entanglement to the main urban sites, but left the peripheries ",{"id":807,"funder":7,"programme":8,"title":808,"piName":10,"institution":809,"country":713,"year":13,"amount":810,"abstract":811},"cordis-european-research-council-award-866448","Harnessing dendritic cell reprogramming for cancer immunotherapy","LUNDS UNIVERSITET","€1,999,835","An important hallmark of cancer is the ability to evade the immune system. Genetic mutations in tumor cells result in the accumulation of tumor antigens (TAs), however, increased cell heterogeneity, downregulation of antigen presentation or inhibition of immune cell infiltration allows immune surveillance evasion. For the first time, direct cell reprogramming offers exciting opportunities to overcome these challenges. My group has recently identified a combination of transcription factors (TFs) ",{"id":813,"funder":7,"programme":8,"title":814,"piName":10,"institution":815,"country":311,"year":13,"amount":60,"abstract":816},"cordis-european-research-council-award-865617","Circuit elements of the cortical circuit for predictive processing","FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION","One promising theoretical framework to explain the function of cortex is predictive processing. It postulates that cortex functions by maintaining an internal model, or internal representation, of the world through a comparison of predictions based on this internal model with incoming sensory information. Implementing predictive processing in a cortical circuit would require a set of distinct functional cell types. These would include neurons that compute a difference between top-down prediction",{"id":818,"funder":7,"programme":8,"title":819,"piName":10,"institution":512,"country":125,"year":13,"amount":820,"abstract":821},"cordis-european-research-council-award-866386","Envisioning the Reward: Neuronal circuits for goal-directed learning","€1,874,780","Our ability to learn relies on the potential of neuronal circuits to change through experience. The overall theme of this project is to understand how sensory cortical circuits are modified by experience and learning. Recent results have shown that learning the association of a visual stimulus with a reward modifies neuronal responses in primary visual cortex (V1). However, the cellular mechanisms underlying these experience-dependent changes remain largely unknown. Computational and experimenta",{"id":823,"funder":7,"programme":8,"title":824,"piName":10,"institution":340,"country":100,"year":13,"amount":825,"abstract":826},"cordis-european-research-council-award-865570","Electrons in Fractal Geometries","€2,718,750","The development of two-dimensional materials has enabled the discovery of new physical phenomena and led to the development of devices that are of crucial importance to our society. For example, we now base the definition of electrical resistance on the quantum Hall effect, a phenomenon exclusive to two dimensions. Similarly, the transistor that underpins every electronic device in use today relies on the manipulation of a two-dimensional electron gas.The realization that a material can have ver",{"id":828,"funder":7,"programme":8,"title":829,"piName":10,"institution":830,"country":246,"year":13,"amount":60,"abstract":831},"cordis-european-research-council-award-864972","Using Evolutionary Algorithms to Understand and Secure Web\u002FEnterprise Systems","HOYSKOLEN KRISTIANIA - ERNST G. MORTENSENS STIFTELSE","--------------------With the EAST project, I aim to improve our understanding of the intrinsic characteristics of web\u002Fenterprise systems related to their security. I will achieve it by designing novel techniques that are able to scale to automatically generate test cases for large web\u002Fenterprise systems, and that can automatically find common types of security threats. This is a necessary stepping stone before reaching the high risk \u002F high impact goal of designing testing systems that can adapt ",{"id":833,"funder":7,"programme":8,"title":834,"piName":10,"institution":835,"country":32,"year":13,"amount":836,"abstract":837},"cordis-european-research-council-award-866274","Equilibrium methods for Resource Allocations and Dynamic Pricing","FONDATION NATIONALE DES SCIENCES POLITIQUES","€1,809,595","This project seeks to build an innovative economic toolbox (ranging from modelling, computation, inference, and empirical applications) for the study of equilibrium models with gross substitutes, with applications to models of matching with or without transfers, trade flows on networks, multinomial choice models, as well as hedonic and dynamic pricing models. While under-emphasized in general equilibrium theory, equilibrium models with gross substitutes are very relevant to these problems as eac",{"id":839,"funder":7,"programme":8,"title":840,"piName":10,"institution":322,"country":100,"year":13,"amount":841,"abstract":842},"cordis-european-research-council-award-864471","Righting the Wrongs. A Life Course Dynamics Approach for Non-Standard Employment","€1,996,377","Aim: To break new ground in the field of Non-Standard Employment (NSE), I develop a novel method for the study of employment trajectories and with this an integral life course framework that explains why and when NSE leads to positive or negative career outcomes.Background: NSE has become a common feature of modern labour markets. Research provides contradictory results on whether NSE leads to prosperous or precarious careers. This research suffers by three shortcomings: 1) the description of ho",{"id":844,"funder":7,"programme":8,"title":845,"piName":10,"institution":846,"country":100,"year":13,"amount":60,"abstract":847},"cordis-european-research-council-award-862137","Pathogen Oriented SNARE Trafficking for Immune Tailoring","RIJKSUNIVERSITEIT GRONINGEN","ImImmune clearance of infectious diseases requires correct T cell activation by macrophages and dendritic cells (DCs) that present peptides derived from ingested pathogens on major histocompatibility complexes (MHC). Yet, macrophages and DCs also ingest self-antigens present in healthy cells and their presentation might trigger autoimmune disease. Presentation of the minority of ingested pathogens is promoted by so-called phagosome-autonomous trafficking. Here, pathogen binding to Toll-like rece",{"id":849,"funder":7,"programme":8,"title":850,"piName":10,"institution":611,"country":612,"year":13,"amount":851,"abstract":852},"cordis-european-research-council-award-866166","Bridging temporal resolution gaps to dissect RNA silencing at the molecular and genomic scale","€1,998,476","The implementation of distinct gene expression profiles is essential for organismal development, physiological responses to external stimuli or pathogens, and defines a primary cause for human disease. While much attention has been paid to the regulation of transcription, the control over RNA fate and function has only recently emerged as a central hallmark of gene regulation with enormous biological, technological and biomedical implications.Here, we propose to study the molecular principles of",{"id":854,"funder":7,"programme":8,"title":855,"piName":10,"institution":657,"country":12,"year":13,"amount":856,"abstract":857},"cordis-european-research-council-award-863911","Physiological roles of the Ribotoxic Stress Response","€1,997,678","The ribotoxic stress response (RSR) surveys the structural and functional integrity of ribosomes and is triggered by diverse groups of ribotoxins (e.g. ricin), UV irradiation and some chemotherapeutics. When presented with impaired ribosomes, the proximal MAPKKK ZAK activates MAP kinases p38 and JNK to initiate a powerful inflammatory response. This signalling contributes to the detrimental reactions to ribotoxins and fatal side effects of cancer therapy. However, despite decades of research int",{"id":859,"funder":7,"programme":8,"title":860,"piName":10,"institution":611,"country":612,"year":13,"amount":861,"abstract":862},"cordis-european-research-council-award-865644","Migration and the Making of the Ancient Greek World","€1,991,686","This project proposes a radical new model for the formation of the ancient Greek world through multi-scalar migration and the later development of Greek identity. By c.550 BCE, the Greek world was a culturally integrated but geographically dispersed entity, comprising over a thousand autonomous communities scattered across the Mediterranean and Black Sea. Migration was a crucial factor in its formation. Yet the nature and scale of this migration remain poorly understood, and there is much heated",{"id":864,"funder":7,"programme":8,"title":865,"piName":10,"institution":535,"country":311,"year":13,"amount":60,"abstract":866},"cordis-european-research-council-award-866074","Analysis of functional tissue motifs for precision medicine in metastatic breast cancer","Cancer precision medicine aims to bring the right drug (or right drug combination) to the right person. To achieve this, the molecular cause of an individual’s disease must be identified and a treatment chosen that targets that cause to remedy the dysfunction. Tumors are dynamic ecosystems with high heterogeneity in tumor, immune, and stromal cell compartments. This complexity is the main obstacle to implementation of precision medicine. Consequently, approaches that rationalize and use tumor ec",{"id":868,"funder":7,"programme":8,"title":869,"piName":10,"institution":870,"country":25,"year":13,"amount":60,"abstract":871},"cordis-european-research-council-award-865973","Interrogating native CRISPR arrays to achieve scalable combinatorial screens and dissect genetic redundancy","HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH","A ubiquitous yet poorly understood theme pervading biology is redundancy, wherein seemingly equivalent components drive shared processes. In cases from development to pathogenesis, untangling the ensuing web of potential genetic interactions can be virtually impossible with conventional techniques. CRISPR technologies, with their propensity for multiplexing, are well poised to address this challenge. However, current CRISPR-based screens have not exceeded more than two targets at a time. Here, I",{"id":873,"funder":7,"programme":8,"title":874,"piName":10,"institution":875,"country":600,"year":13,"amount":876,"abstract":877},"cordis-european-research-council-award-864017","Learning to Control - Smart and Data-Driven Formal Methods for Cyber-Physical Systems control","UNIVERSITE CATHOLIQUE DE LOUVAIN","€1,911,250","The engineered systems surrounding us are increasingly hard to control. Not only the complicated interaction of the physical processes with the machines that control them, but also specifications (cyber-security, safety, privacy, resilience, resource-efficiency, decentralization) are more and more complex, and critical. Last but not least, in an increasing number of situations, no model of the system is available (or the model is too complex), and one needs to learn the optimal way of controllin",{"id":879,"funder":7,"programme":8,"title":880,"piName":10,"institution":712,"country":713,"year":13,"amount":680,"abstract":881},"cordis-european-research-council-award-864720","Leader-follower hybrid control and task planning for multi-agent systems under spatiotemporal logic specifications","Multi-agent control is a popular research topic due to its applications in a variety of areas. The main approach has been to incorporate tools from single-agent control to the multi-agent setup. However, many applications involve more complex tasks that may not be cast as a classic control objective, while the agents may be subject to constraints in space and time.  A current trend is thus to use formal verification in order to specify more general task specifications that induce a sequence of c",{"id":883,"funder":7,"programme":8,"title":884,"piName":10,"institution":885,"country":87,"year":13,"amount":886,"abstract":887},"cordis-european-research-council-award-864616","Healthy lifespan inequality:  Measurement, trends and determinants","CENTRO DE ESTUDIOS DEMOGRAFICOS","€1,448,125","Despite its widespread use and popularity, life expectancy (LE) has two shortcomings. First, its definition only takes into consideration mortality levels, thus ignoring the health status of those who remain alive. Second, LE is an average that does not explain how length of life is distributed across the population. These limitations have generated two strands of research (i.e. the study of ‘health expectancies’ (HE) and ‘lifespan inequality’ (LI)) that, so far, have developed independently fro",{"id":889,"funder":7,"programme":8,"title":890,"piName":10,"institution":891,"country":25,"year":13,"amount":60,"abstract":892},"cordis-european-research-council-award-864875","The Oligo-Vascular interface: understanding its properties and functions","UNIVERSITATSKLINIKUM BONN","Oligodendrocytes (OLs) are the glia cells that produce myelin in the central nervous system (CNS). Despite the severe outcome of demyelinating diseases, like multiple sclerosis (MS), little is known about the mechanisms by which myelin is disrupted or why remyelination fails in disease. Thus, a substantial advance in the understanding of oligodendrocyte biology and myelin pathology is required in order to develop successful treatments for demyelinating diseases.Recent research indicates that apa",{"id":894,"funder":7,"programme":8,"title":895,"piName":10,"institution":457,"country":100,"year":13,"amount":896,"abstract":897},"cordis-european-research-council-award-865898","Building a Better Tomorrow: Development Knowledge and Practice in Central Asia and Beyond, 1970-2017","€1,997,605","The landscape of post-Soviet Central Asia (Tajikistan, Uzbekistan, Kyrygzstan, Kazakhstan, Turkmenistan) is littered with the physical remnants of Soviet development, both positive health clinics and schools  and negative - decaying factories, polluted soil, and dried out rivers. Less visible are Soviet developments political, intellectual, and institutional legacies.  Yet just as post-socialist states and international development organizations have been forced to deal with the physical legacie",{"id":899,"funder":7,"programme":8,"title":900,"piName":10,"institution":646,"country":464,"year":13,"amount":60,"abstract":901},"cordis-european-research-council-award-864068","Deciphering the principles governing robust targeting of proteins to organelles","Half of eukaryotic proteins require targeting to specific organelles to execute their function. Research from multiple labs, including our own, has uncovered some of the pathways that recognize such cargo proteins and target them in an efficient and regulated fashion. However, many central pathways are clearly still missing. Importantly, current studies tend to focus on single cargo proteins and how they utilize one particular targeting pathway, creating an over-simplified view of the cellular r",{"id":903,"funder":7,"programme":8,"title":904,"piName":10,"institution":905,"country":713,"year":13,"amount":906,"abstract":907},"cordis-european-research-council-award-866510","A new translational strategy for tailored treatment of type 2 diabetes","GOETEBORGS UNIVERSITET","€1,957,230","Type 2 diabetes (T2D) is an escalating health problem of enormous proportions. Current treatment strategies are unable to stop disease progression and prevent the devastating complications. Clinical guidelines emphasise the need for personalized treatment. However, this is currently implemented on trial-and-error fashion. We have recently found that T2D patients can be divided into four clusters, each with different characteristics. This represents a major step forward by pointing out the high v",{"id":909,"funder":7,"programme":8,"title":910,"piName":10,"institution":405,"country":25,"year":13,"amount":911,"abstract":912},"cordis-european-research-council-award-864491","Neuronal Information through Neuronal Interactions","€1,999,375","Our thoughts and actions result from the activity of functionally specialized neurons in the brain. We have learned a lot about how individual neurons encode sensory, cognitive and motor information. But we lack understanding of how this information comes about. The fundamental, yet rarely addresses, assumption is that this information results from neuronal interactions within local and large-scale brain networks. However, little is known about which specific interactions establish information c",{"id":914,"funder":7,"programme":8,"title":915,"piName":10,"institution":646,"country":464,"year":13,"amount":916,"abstract":917},"cordis-european-research-council-award-864578","Barcoding gene expression dynamics at single-molecule resolution","€2,368,531","Gene expression is an inherently stochastic process. Random expression bursts cause tremendous cell-to-cell variations in mRNA and protein levels. The consequences are beneficial in some instances, e.g., in cell differentiation, and harmful in others, e.g., in bacterial drug tolerance. A key interest in biology is therefore to decipher the kinetics that characterise this noise. What is the distribution of transcription rates in a cell population? Are gene expression dynamics heritable? Do gene n",{"id":919,"funder":7,"programme":8,"title":920,"piName":10,"institution":921,"country":100,"year":13,"amount":922,"abstract":923},"cordis-european-research-council-award-865459","Deconstructing gene regulation through functional dissection of the 3D genome","STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS","€1,997,425","The three-dimensional organization of the genome inside the nucleus (3DG) is crucial for gene regulation. Although the fundamental building blocks of the 3DG have been identified, how they contribute to gene regulation is incompletely understood. In recent years my lab has started to functionally dissect the 3DG in order to understand the effects on gene expression. The current proposal intends to expand this work and aims to i) broaden the array of proteins that are known organize the 3DG, ii) ",{"id":925,"funder":7,"programme":8,"title":926,"piName":10,"institution":788,"country":713,"year":13,"amount":927,"abstract":928},"cordis-european-research-council-award-864788","Revealing the contribution of liver macrophage populations to NASH in insulin resistance","€1,999,781","Non-alcoholic steatohepatitis (NASH), the most common chronic liver disease worldwide, is an unmet medical need with no approved therapies and debilitating consequences for patients. Obesity-associated insulin resistance is a high-risk factor for the development of NASH. The prevailing paradigm is a multiple hit process, whereby lipid accumulation in the liver of obese patients leads to oxidative stress and increased production of inflammatory cytokines by macrophages. However, my research group",{"id":930,"funder":7,"programme":8,"title":931,"piName":10,"institution":512,"country":125,"year":13,"amount":10,"abstract":932},"cordis-european-research-council-award-866355","Molecular Principles of Mammalian Axonemal Dynein Assembly","Motile cilia are tiny microtubule-based projections which create fluid flow and are essential to human health. Cilia movement is powered by coordinated action of complex macromolecular motors, the axonemal dyneins. During differentiation, as cells produce hundreds of motile cilia, millions of dynein subunits must be pre-assembled in the cytoplasm into very large complexes in the correct stoichiometry which are then trafficked into growing cilia. This poses a sizeable challenge for the cell in te",{"id":934,"funder":7,"programme":8,"title":935,"piName":10,"institution":936,"country":25,"year":13,"amount":937,"abstract":938},"cordis-european-research-council-award-866008","Robust, Explainable Deep Networks in Computer Vision","TECHNISCHE UNIVERSITAT DARMSTADT","€1,999,814","Deep learning approaches, mostly in the form of convolutional neural networks (CNNs), have taken the field of computer vision by storm. While the progress in recent years has been astounding, it would be dangerous to believe that important problems in computer vision are close to being solved. Many canonical deep networks for vision tasks ranging from image understanding to 3D reconstruction or motion estimation perform incredibly well on dataset, i.e.~in the very setting in which they have been",{"id":940,"funder":7,"programme":8,"title":941,"piName":10,"institution":457,"country":100,"year":13,"amount":60,"abstract":942},"cordis-european-research-council-award-864035","New Approaches to Uncover Dark Matter in the post-WIMP Era","Uncovering the particle nature of dark matter (DM) is one of the primary goals of fundamental physics and cosmology today. DM accounts for 85% of the matter in the Universe, but only its gravitational effects on the motion of celestial objects have been observed. DM research is arguably in a critical state: the long-prevailing WIMP (weakly interacting massive particle) paradigm has not been confirmed experimentally up to now, putting the focus on the electroweak scale under serious pressure. I p",{"id":944,"funder":7,"programme":8,"title":945,"piName":10,"institution":946,"country":483,"year":13,"amount":947,"abstract":948},"cordis-european-research-council-award-866207","Globalisation- and Technology-Driven Labour Market Change and Fertility","UNIWERSYTET WARSZAWSKI","€1,998,100","LABFER is the first project that will LABFER is the first project that will comprehensively describe and evaluate fertility consequences of the unprecedented changes in the labour market, caused by digitalisation and globalisation. These changes have been taking place during the last three decades and intensified after the Great Recession. They are reflected in: rising demand for skills, massive worker displacement, spread of new work arrangements, increasing work demands and growing inequalitie",{"id":950,"funder":7,"programme":8,"title":951,"piName":10,"institution":606,"country":100,"year":13,"amount":952,"abstract":953},"cordis-european-research-council-award-865375","Hexatic hydrodynamics: from driven soft matter to biological tissues","€1,897,018","How do hexatics flow? Forty years after Nelson’s and Halperin’s first prediction of the existence of this phase of two-dimensional matter, intermediate between crystalline solid and isotropic liquid, this seemingly elementary question is still unanswered. Whereas the delicate nature of hexatics could partially justify this oversight, recent findings in tissue mechanics have created the urgent demand to fill this gap, by providing this phase with unexpected biological relevance. Like two-dimensio",{"id":955,"funder":7,"programme":8,"title":956,"piName":10,"institution":957,"country":958,"year":13,"amount":60,"abstract":959},"cordis-european-research-council-award-864957","Dissecting novel mechanisms of iron regulation during macrophage-fungal interplay","IDRYMA TECHNOLOGIAS KAI EREVNAS","EL","Airborne filamentous fungi (molds) are major causes of respiratory diseases in an expanding population of patients with complex immune and metabolic defects. Invasive mold infections (IMI) are associated with substantial mortality and enormous economic impact. Understanding pathogenesis of IMI is an unmet need for design of better therapies. We have put forward a novel mechanism for the pathogenesis of IMI, according to which development of IMI requires two discrete mechanisms (a) phagosome matu",{"id":961,"funder":7,"programme":8,"title":962,"piName":10,"institution":963,"country":12,"year":13,"amount":964,"abstract":965},"cordis-european-research-council-award-865230","A Single-Photon Source Featuring Unity Efficiency And Unity Indistinguishability For Scalable Optical Quantum Information Processing","DANMARKS TEKNISKE UNIVERSITET","€2,119,637","Within optical quantum information processing, the quantum bits are encoded on single photons and their quantum mechanical properties are exploited to build new functionality. A prime example is the quantum computer, which can be built simply from single-photon sources and detectors, and simple optical components. However for scalable optical quantum computing involving hundreds of photons, the performance requirements for the single-photon source are daunting: the source must feature near-unity",{"id":967,"funder":7,"programme":8,"title":968,"piName":10,"institution":969,"country":311,"year":13,"amount":970,"abstract":971},"cordis-european-research-council-award-863929","Testing the law of gravity with novel large-scale structure observables","UNIVERSITE DE GENEVE","€1,946,064","The objective of my proposal is to test the law of gravity using the large-scale structure of our Universe. The way galaxies are distributed in the sky, as well as their observed size and shape, are directly sensitive to the theory of gravity. Upcoming large-scale structure surveys are expected to deliver very precise pictures of our sky over a wide range of scale and redshift, opening the way to a whole new range of tests of gravity. The aim of my project is to construct novel cosmological obse",{"id":973,"funder":7,"programme":8,"title":974,"piName":10,"institution":975,"country":600,"year":13,"amount":976,"abstract":977},"cordis-european-research-council-award-862246","Silent mutations in cancer","KATHOLIEKE UNIVERSITEIT LEUVEN","€1,999,977","Our genome contains 20 000 genes, which are transcribed into mRNAs. These mRNAs are then in turn translated into proteins that exert the cellular functions. In the past decade, researchers have analysed the genetic sequence of all protein coding genes in thousands of tumor samples, with the aim to identify gene defects (‘mutations’) that cause cancer. In most of these studies, only gene mutations that cause amino acid changes in the proteins for which they encode were analysed, and it was assume",{"id":979,"funder":7,"programme":8,"title":980,"piName":10,"institution":981,"country":53,"year":13,"amount":982,"abstract":983},"cordis-european-research-council-award-865863","Architectural Culture of the Early Modern Eastern Adriatic","UNIVERSITA CA' FOSCARI  VENEZIA","€1,999,750","During the 15th century, the political process of reducing the Eastern Adriatic, here considered as encompassing what is now littoral of Slovenia, Croatia and Montenegro, to a thin strip of border territories substantially separated from the continental massive to which they belong, reached its conclusion. The insularity of its large natural archipelago, i.e. almost exclusive dependence on the maritime communications, became characteristic even of mainland coastal towns, with lasting consequence",{"id":985,"funder":7,"programme":8,"title":986,"piName":10,"institution":987,"country":125,"year":13,"amount":262,"abstract":988},"cordis-european-research-council-award-866328","Dominant cis-regulatory variation to improve quantitative traits in polyploid wheat","JOHN INNES CENTRE","Urgent action is needed to sustainably intensify global crop production using science-based solutions. Across crops, selection for mutations in cis-regulatory regions of transcription factors has been at the centre of the domestication and breeding process to improve productivity traits. Further efforts to advance towards this goal, however, are hampered in the young polyploid genome of wheat as many genes are present as two or three homoeologous copies with overlapping functions. As a result, r",{"id":990,"funder":7,"programme":8,"title":991,"piName":10,"institution":731,"country":100,"year":13,"amount":992,"abstract":993},"cordis-european-research-council-award-864929","4D Breast Imaging for Personalized Breast Cancer Treatment","€2,308,393","The next major step forward in the fight against breast cancer will be the introduction of personalized treatment. Such a precision medicine approach would maximize the rate of complete response, minimize ineffective therapy and morbidity, and eliminate the need for localized breast cancer surgery.To achieve this, I will create a novel functional imaging modality, 4D dynamic contrast enhanced dedicated breast computed tomography (4D DCE-BCT), capable of characterizing every different genomic, mo",{"id":995,"funder":7,"programme":8,"title":996,"piName":10,"institution":997,"country":125,"year":13,"amount":998,"abstract":999},"cordis-european-research-council-award-865222","Bridging Europe: A Quaternary Timescale For The Expansion And Evolution Of Humans","UNIVERSITY OF YORK","€1,999,278","Timing is everything in archaeology; EQuaTe will build on exciting advances in amino acid and thermoluminescence (TL) dating to provide a chronology that will deepen our understanding of early human evolution and migration throughout Europe.During the Quaternary (the last 2.6 million years), Europe witnessed major climatic oscillations, with periodic expansion of ice sheets into lowland areas, changes of sea-level, re-organization of plant and animal communities, and the evolution and migration ",{"id":1001,"funder":7,"programme":8,"title":1002,"piName":10,"institution":1003,"country":100,"year":13,"amount":60,"abstract":1004},"cordis-european-research-council-award-864499","What causes therapy-related malignancies in childhood cancer survivors? Dissecting the etiology of second cancers","PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV","Therapy-related malignancies are a major cause of long-term mortality among childhood cancer survivors. However, it is unclear how exposure to chemo- and\u002For radiotherapy early in life induces carcinogenesis. My aim is to determine the mechanisms and rate-limiting steps underlying the genesis of second malignancies in childhood cancer survivors. For this, we will focus on studying the etiology of therapy-related myeloid malignancies (t-MNs). I have pioneered methods to characterize mutation accum",{"id":1006,"funder":7,"programme":8,"title":1007,"piName":10,"institution":969,"country":311,"year":13,"amount":1008,"abstract":1009},"cordis-european-research-council-award-865026","Molecular pathology of anti-viral T cell responses in the central nervous system","€1,999,954","Immune responses against viruses in the central nervous system (CNS) can result in devastating outcomes. Even non-cytolytic CD8+ T cell interactions, which purge viruses from neurons without triggering cell death, can induce permanent damage. Yet, how this immune response irreversibly disrupts neuronal homeostasis remains unclear.Here, we will elucidate the molecular mechanisms that underlie non-cytolytic CD8+ T cell engagement with infected neurons and their consequences on neuron function in v",{"id":1011,"funder":7,"programme":8,"title":1012,"piName":10,"institution":535,"country":311,"year":13,"amount":1013,"abstract":1014},"cordis-european-research-council-award-864309","The Just City: The Ciceronian Conception of Justice and Its Reception in the Western Tradition","€1,775,000","One of the most innovative, and historically most influential, notions in the Western debate about justice is the political theory of Cicero (106-43 BCE). This project examines the ways a Ciceronian conception of justice came to be used in political argument at specific inflection points in the history of political thought. Ciceronian justice, responding to the breakdown of order, marked a significant departure from earlier Greek theories of justice. Cicero’s law-centered views on justice, both ",{"id":1016,"funder":7,"programme":8,"title":1017,"piName":10,"institution":1018,"country":25,"year":13,"amount":60,"abstract":1019},"cordis-european-research-council-award-865694","Predicting the evolution of complex phage-host interactions","FRIEDRICH-SCHILLER-UNIVERSITÄT JENA","What determines if a phage can infect a host? This question arises as we work to understand the ecological roles of the hundreds of thousands of unknown viruses that I and others have discovered around the world. Phages are the most abundant life forms on Earth with important applications in medicine and biotechnology and far-ranging effects on microbial community functioning in all environments. Phage-host interactions (PHI) are an emergent trait that depends on the complex integration of facto",{"id":1021,"funder":7,"programme":8,"title":1022,"piName":10,"institution":646,"country":464,"year":13,"amount":60,"abstract":1023},"cordis-european-research-council-award-863589","Long noncoding RNAs: Impact on Gene Regulatory Networks","Tens of thousands of loci in mammalian genomes produce long RNAs that do not go on to produce functional proteins, and are collectively called long noncoding RNAs (lncRNAs). A growing number of these have been shown to be important in various biological processes and human diseases. How lncRNA genes function and, specifically, how their production, maturation, or RNA products affect other gene regulatory processes remains poorly understood and is the focus of this proposal. We will build on a ri",{"id":1025,"funder":7,"programme":8,"title":1026,"piName":10,"institution":1027,"country":87,"year":13,"amount":60,"abstract":1028},"cordis-european-research-council-award-865554","New carbon reactivity rules for molecular editing","FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA","The major goal of this application is to develop the catalytic generation of conceptually-novel carbyne equivalents and related species, and to study their reactivity towards organic matter. The catalytic activation of designed sources will reveal new reactivity rules at carbon that have been missing, not only in the design and discovery of new chemical reactions, but also in their use to build molecular complexity. Our approach will rely on novel activation modes that unlock elusive and useful ",{"id":1030,"funder":7,"programme":8,"title":1031,"piName":10,"institution":1032,"country":32,"year":13,"amount":1033,"abstract":1034},"cordis-european-research-council-award-866186","Role of Tissue Mechanics in Embryonic Self-Organization and Cell Fate Plasticity","INSTITUT PASTEUR","€1,995,334","How molecular and mechanical cues interplay to coordinate the morphogenesis and patterning of embryonic structures is an open question in developmental biology. The early avian embryo is an ideal model for the study of such interplay as it exhibits highly regulative development, is greatly amenable to live imaging approaches and can be readily mechanically challenged. Whereas avian embryos have long been known to remarkably adapt and readjust cell fate upon surgical perturbations, such regulativ",{"id":1036,"funder":7,"programme":8,"title":1037,"piName":10,"institution":1038,"country":25,"year":13,"amount":1039,"abstract":1040},"cordis-european-research-council-award-864698","Solvated Ions in Solid Electrodes: Alternative routes toward rechargeable batteries based on abundant elements","HUMBOLDT-UNIVERSITAET ZU BERLIN","€1,997,811","Storing large amounts of electrical energy is a major challenge for the forthcoming decades. Today, lithium-ion batteries (LIBs) are considered the best option for electric vehicles and grid storage but these rising markets put severe pressure on resource and supply chains. The principle of LIBs is based on solid electrodes separated by a liquid electrolyte between which Li ions are reversibly exchanged during charge and discharge. The efficient Li+ transport in the different phases and across t",{"id":1042,"funder":7,"programme":8,"title":1043,"piName":10,"institution":535,"country":311,"year":13,"amount":1044,"abstract":1045},"cordis-european-research-council-award-865803","Intrapopulation communication and collective cell decisions of hematopoietic stem cells","€2,312,500","Hematopoietic stem cells (HSCs) contribute to blood cell production throughout life and are found at rare, yet tightly regulated frequencies in adult bone marrow (BM). During embryonic and postnatal development, HSCs expand through continuous self-renewing proliferation. Upon entry into adulthood the vast majority of HSCs synchronously convert to a quiescent state. From then on, at any given moment very few HSCs are found in active stages of cell cycle, which suffices to compensate basal HSC los",{"id":1047,"funder":7,"programme":8,"title":1048,"piName":10,"institution":1049,"country":87,"year":13,"amount":1050,"abstract":1051},"cordis-european-research-council-award-864333","States, Nationalism, and the Relationship between Ethnic Diversity and Public Goods Provision","INSTITUT BARCELONA D ESTUDIS INTERNACIONALS, FUNDACIO PRIVADA","€1,985,088","Around the world, nationalist politicians see migrants and ethnic minorities as undeserved receivers of public goods. What underpins these exclusionary claims is the thesis that ethnic diversity impedes the prospects of economic progress and social welfare.Does this thesis withstand systematic inquiry? At a first glance, there are plenty of studies that link ethnic heterogeneity to the underprovision of public goods. An influential literature in political economy asserts a strong association bet",{"id":1053,"funder":7,"programme":8,"title":1054,"piName":10,"institution":322,"country":100,"year":13,"amount":60,"abstract":1055},"cordis-european-research-council-award-864519","Ecological Origins of  Cross-Societal Variation in Cooperation","Societies that contain widespread cooperation can solve problems of public good provision and resource conservation, yet many societies fail to display the cooperation necessary to solve these problems. A puzzle facing the social sciences is understanding the origin of cross-societal variation in cooperation. Strikingly, multiple disciplines propose the same, not yet established, explanation: ecological conditions, such as subsistence, environmental hazards, and relational mobility, determine ho",{"id":1057,"funder":7,"programme":8,"title":1058,"piName":10,"institution":1059,"country":25,"year":13,"amount":1060,"abstract":1061},"cordis-european-research-council-award-864164","Neural mechanisms, functional roles and pathophysiological relevance of human grid cell-like representations","RUHR-UNIVERSITAET BOCHUM","€1,999,243","The entorhinal cortex contains grid cells, a major cell type underlying spatial navigation. At the same time, it is amongst the first areas of the brain to be affected by Alzheimer’s disease (AD). In humans, grid cell-like representations (GCLRs) have been proposed as a network-level signature of grid cells that can be recorded non-invasively via functional magnetic resonance imaging (fMRI). I have recently demonstrated that there is a disruption of GCLRs in genetic AD risk carriers at young age",{"id":1063,"funder":7,"programme":8,"title":1064,"piName":10,"institution":1065,"country":25,"year":13,"amount":1066,"abstract":1067},"cordis-european-research-council-award-864121","Macro-Nanomedicine to Treat Metastatic Cancer","UNIVERSITAETSKLINIKUM AACHEN","€1,979,375","Metastatic cancer is a complex and highly heterogenous disease, which is very difficult to treat. The aim of the Meta-Targeting project is to establish a holistic, rational and realistic nanomedicine-based approach to improve the treatment of metastatic breast cancer. Concrete objectives are: (1) the development of polymeric micelles which can be efficiently and stably co-loaded with three different drugs and with an imaging agent; (2) the use of physical and pharmacological means to modulate th",{"id":1069,"funder":7,"programme":8,"title":1070,"piName":10,"institution":1071,"country":125,"year":13,"amount":10,"abstract":1072},"cordis-european-research-council-award-864637","ANTarctic Sea Ice Evolution from a novel biological archive","UNIVERSITY OF DURHAM","Antarctic sea ice is a critical component of Earth’s climate system. Seasonal fluctuations support unique ecosystems and impact planetary albedo, ocean-atmosphere exchanges of heat and climatically-active gases (e.g. CO2), and formation of intermediate and deep water masses which create the world’s largest sink of heat and carbon. The properties of the sea-ice pack are complex: despite its climatic significance, Antarctic sea ice is challenging to observe and to model, leading to low confidence ",{"id":1074,"funder":7,"programme":8,"title":1075,"piName":10,"institution":112,"country":25,"year":13,"amount":1076,"abstract":1077},"cordis-european-research-council-award-863934","Unravelling Glycochemistry with Ion Mobility Spectrometry and Gas-Phase Spectroscopy","€2,642,850","Oligosaccharides or glycans are essential in nature and central participants in virtually every biological process. The extensive structural diversity enables glycans to encode rich information in biological functions; however, it also creates major challenges in almost all aspects of the glycosciences. The synthetic formation of glycosidic bonds during glycan assembly for example, is mechanistically still not fully understood. This is largely a result of highly-reactive, but short-lived oxocarb",{"id":1079,"funder":7,"programme":8,"title":1080,"piName":10,"institution":310,"country":311,"year":13,"amount":60,"abstract":1081},"cordis-european-research-council-award-866004","Three-dimensional dynamic views of proteomes as a novel readout for physiological and pathological alterations","Protein expression screens are routinely used to identify biological processes deregulated upon disease development or upon specific cellular perturbations. Generating molecular hypotheses from these ‘omic data remains challenging, however, and many molecular events that modulate protein function do not involve altered protein levels. With this project, I propose a new paradigm. I propose that by measuring altered structures of proteins on a global scale, we can capture altered functional states",{"id":1083,"funder":7,"programme":8,"title":1084,"piName":10,"institution":457,"country":100,"year":13,"amount":60,"abstract":1085},"cordis-european-research-council-award-865931","Responsible sharing: Paving the path for transparent trust","The collaborative economy is estimated to add €160-€572 billion to the EU economy. Faced with blurry definitions in this emerging market, regulators use a top-down approach and introduce regulations that often fail to consider users’ behaviour. Although considerable knowledge on top-down regulatory solutions for the collaborative economy is accumulating, little is known about the bottom-up psychological factors driving the collaborative economy users’ behaviour. Online platforms rely and promote",{"id":1087,"funder":7,"programme":8,"title":1088,"piName":10,"institution":1089,"country":100,"year":13,"amount":1090,"abstract":1091},"cordis-european-research-council-award-866478","Uncovering the epigenetic signature of female-specifiC biological networks and key driver genes of coronary ArteRy diseasE","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","€1,999,979","Cardiovascular disease causes 51% of deaths in women and 42% of deaths in men in Europe. Women are contributing mostly to the worrying trend of increases in hospitalizations for coronary artery disease (CAD) at younger ages. Missed and delayed diagnoses in women are more common than in men, as the pathophysiology of CAD in women is different than in men. Men often have atherosclerotic plaque rupture as underlying mechanism for CAD whereas women more often suffer from plaque erosion. Plaque erosi",{"id":1093,"funder":7,"programme":8,"title":1094,"piName":10,"institution":1095,"country":200,"year":13,"amount":1096,"abstract":1097},"cordis-european-research-council-award-865974","Unveiling CO2 chemisorption mechanisms in solid adsorbents via surface-enhanced ex(in)-situ NMR","UNIVERSIDADE DE AVEIRO","€1,999,793","Reaching a historic high of 3Reaching a historic high of 32.5 gigatonnes in 2017, global carbon dioxide emissions from fossil fuels combustion continue to increase. CO2 removal technologies are part of the solution to tackle this crucial environmental challenge. Because of their lower regeneration cost, amine-modified porous silicas (AMPS) are the most promising CO2-adsorbents for replacing the decades-old liquid amine scrubbing technology. AMPS are “moisture-tolerant” and selectively chemisorb ",200,{"programme":8,"total":1100,"withPiName":1101,"firstYear":1102,"lastYear":1103,"countryCount":1104,"perYear":1105,"topInstitutions":1145,"topCountries":1214},4499,349,2014,2027,45,[1106,1108,1111,1114,1117,1120,1123,1125,1128,1131,1134,1137,1140,1143],{"year":1102,"count":1107},303,{"year":1109,"count":1110},2015,335,{"year":1112,"count":1113},2016,322,{"year":1115,"count":1116},2017,327,{"year":1118,"count":1119},2018,403,{"year":1121,"count":1122},2019,300,{"year":13,"count":1124},277,{"year":1126,"count":1127},2021,321,{"year":1129,"count":1130},2022,364,{"year":1132,"count":1133},2023,359,{"year":1135,"count":1136},2024,366,{"year":1138,"count":1139},2025,375,{"year":1141,"count":1142},2026,416,{"year":1103,"count":1144},31,[1146,1149,1152,1155,1158,1161,1164,1166,1168,1171,1173,1176,1179,1181,1183,1186,1189,1192,1195,1198,1200,1203,1206,1209,1212],{"name":1147,"count":1148},"Centre National de la Recherche Scientifique CNRS",229,{"name":1150,"count":1151},"University of Oxford",89,{"name":1153,"count":1154},"Weizmann Institute of Science",78,{"name":1156,"count":1157},"University of Cambridge",77,{"name":1159,"count":1160},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",63,{"name":1162,"count":1163},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",55,{"name":1165,"count":1163},"Institut National de la Sante Et de la Recherche Medicale",{"name":1167,"count":1163},"Kobenhavns Universitet",{"name":1169,"count":1170},"Universiteit Utrecht",51,{"name":1172,"count":1170},"University College London",{"name":1174,"count":1175},"Tel Aviv University",49,{"name":1177,"count":1178},"The Hebrew University of Jerusalem",43,{"name":1180,"count":1178},"Universiteit Gent",{"name":1182,"count":1178},"Universiteit van Amsterdam",{"name":1184,"count":1185},"Ludwig-Maximilians-Universitaet Muenchen",42,{"name":1187,"count":1188},"Technische Universitaet Muenchen",41,{"name":1190,"count":1191},"Eidgenoessische Technische Hochschule Zuerich",40,{"name":1193,"count":1194},"Universitat Wien",39,{"name":1196,"count":1197},"Helsingin Yliopisto",38,{"name":1199,"count":1197},"Technische Universiteit Delft",{"name":1201,"count":1202},"Katholieke Universiteit Leuven",37,{"name":1204,"count":1205},"Universitetet I Oslo",36,{"name":1207,"count":1208},"École Polytechnique Fédérale de Lausanne",34,{"name":1210,"count":1211},"The University of Edinburgh",32,{"name":1213,"count":1144},"Lunds Universitet",[1215,1217,1219,1221,1223,1225,1227,1229,1230,1232,1234,1236,1238,1240,1242,1244,1246,1249,1251,1254,1256,1259,1261,1263,1265],{"name":25,"count":1216},810,{"name":125,"count":1218},559,{"name":32,"count":1220},490,{"name":100,"count":1222},428,{"name":87,"count":1224},315,{"name":53,"count":1226},267,{"name":464,"count":1228},219,{"name":311,"count":1098},{"name":713,"count":1231},170,{"name":600,"count":1233},166,{"name":612,"count":1235},146,{"name":12,"count":1237},127,{"name":346,"count":1239},94,{"name":246,"count":1241},85,{"name":94,"count":1243},82,{"name":200,"count":1245},68,{"name":1247,"count":1248},"GB",47,{"name":1250,"count":1205},"CZ",{"name":1252,"count":1253},"HU",24,{"name":958,"count":1255},22,{"name":1257,"count":1258},"US",21,{"name":483,"count":1260},20,{"name":496,"count":1262},14,{"name":552,"count":1264},13,{"name":1266,"count":1267},"EE",8]