[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-consolidator-grant-2021":3,"awarded-stats-erc-consolidator-grant":1125},{"awarded":4,"total":1124},[5,16,22,26,31,36,43,49,56,63,68,73,78,85,90,97,103,109,114,119,125,130,137,143,149,154,160,165,172,179,185,192,199,206,212,218,224,230,236,241,248,253,258,263,269,274,279,284,289,295,300,305,311,316,322,327,333,338,343,349,354,359,365,371,376,381,387,392,396,402,407,413,418,422,427,432,437,442,448,454,459,465,470,477,483,489,495,501,506,511,516,522,528,534,541,547,552,558,563,569,575,580,585,591,596,602,608,614,620,626,632,638,644,650,655,660,666,672,678,683,689,694,700,706,712,718,723,728,734,740,746,752,756,762,767,773,779,785,791,797,803,809,815,819,825,830,837,843,848,854,859,865,871,877,882,887,892,897,902,907,912,917,923,928,932,939,945,949,955,960,965,971,976,982,987,991,997,1002,1007,1014,1018,1022,1028,1032,1037,1043,1049,1054,1060,1065,1069,1075,1081,1086,1090,1096,1101,1107,1113,1119],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-866222","European Research Council","ERC Consolidator Grant","Deciphering the niche adaptations of a gut commensal involved in educating the host immune system",null,"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","FR",2021,"€1,999,948","The gut microbiota plays an integral part in driving the postnatal maturation of the gut immune system and in protecting the host from pathogens. The commensal segmented filamentous bacteria (SFB) plays a critical role in these processes through its intimate attachment to the ileal epithelium using a unique pointed tip structure on its unicellular infectious particle. SFB induces a broad pro-inflammatory immune activation, and notably a striking induction of IgA and Th17 cell responses, that fos",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":12,"year":13,"amount":20,"abstract":21},"cordis-european-research-council-award-101001841","Optical imaging of retinal function for gene and cell therapies","FONDATION DE COOPERATION SCIENTIFIQUE VOIR ET ENTENDRE","€1,999,720","For patients suffering from inherited retinal diseases (IRDs), gene and cell therapies offer hope of preserving or restoring vision. Retinal imaging is crucial, to first phenotype patients to determine which cells are degenerated and devise an appropriate therapeutic path; then in the lab for cell therapy development, and finally back in the clinic to monitor therapeutic success in patients who have been treated with gene or cell therapy. To date, the imaging tools used in the clinic do not prov",{"id":23,"funder":7,"programme":8,"title":24,"piName":10,"institution":11,"country":12,"year":13,"amount":10,"abstract":25},"cordis-european-research-council-award-101003329","Parkinson's disease: does it all start with gut inflammation?","Burgeoning evidence shows that Parkinson's disease (PD) involves the gut before affecting the brain, leading to the fascinating hypothesis that the gut might be the site of disease initiation. Remarkably, the gut origin of PD is still poorly understood. Multiple triggers could serve as a first insult: infections, dysbiosis, and inflammatory bowel diseases (IBDs). All these conditions ultimately converge on intestinal inflammation. Thus, an intriguing hypothesis is that PD is a systemic illness t",{"id":27,"funder":7,"programme":8,"title":28,"piName":10,"institution":11,"country":12,"year":13,"amount":29,"abstract":30},"cordis-european-research-council-award-101001420","RESilience to Early Developmental Adversity: can children's environment help them overcome the odds?","€1,541,617","Socioeconomic inequalities in childrens neurodevelopment and mental health are observed from early onwards and widen over time. Moreover, children whose parents are immigrant, particularly if they belong to ethnic minority groups, may be especially vulnerable. Yet there are important inter-individual differences in development, implying the possibility of resilience. My project will examine the consequences of multiple forms of socioeconomic adversity in childrens family and broader social envir",{"id":32,"funder":7,"programme":8,"title":33,"piName":10,"institution":11,"country":12,"year":13,"amount":34,"abstract":35},"cordis-european-research-council-award-864893","Neurofilaments in Health and neurodegenerative diseases","€1,874,863","Neurofilaments (NFs) are a highly dynamic cytoskeletal network, which exhibits essential functions in neurons and are key actors in neurodegeneration. NFs are not only a genetic cause of neuronal death in human, their abnormal aggregation is an early pathological hallmark in disease, and their genetic removal from axons has shown spectacular benefits in delaying disease onset, extending survival and restoring neurological functions in mouse models.  In this project, I propose the concept that th",{"id":37,"funder":7,"programme":8,"title":38,"piName":10,"institution":39,"country":40,"year":13,"amount":41,"abstract":42},"cordis-european-research-council-award-101001205","Power to the LHC data: an ASYmptotically MOdel-independent measurement of the W boson mass","UNIVERSITA DI PISA","IT","€1,683,750","Despite its success in describing the sub-nuclear realm, the Standard Model of particle and field interactions cannot account for a number of experimental facts that constitute evidence of new and unknown physics. Sitting at both the energy and intensity frontier, the LHC grants the highest chances for solving the current puzzle. By exploiting the data collected by the CMS experiment at the LHC, ASYMOW aims at attaining an unprecedented experimental accuracy on a fundamental parameter of Nature:",{"id":44,"funder":7,"programme":8,"title":45,"piName":10,"institution":46,"country":40,"year":13,"amount":47,"abstract":48},"cordis-european-research-council-award-866127","CAPTURING THE PHYSICS OF LIFE ON 3D-TRAFFICKING SUBCELLULAR NANOSYSTEMS","SCUOLA NORMALE SUPERIORE","€1,985,750","Which physical principles govern life regulation at the level of subcellular, membrane-enclosed nanosystems, such as transport vesicles and organelles? How do they achieve controlled movements across the crowded intracellular world? Which is the structural and functional organization of their surface and their lumen? This is only a small subset of key open questions that the biophysical approach envisaged here will allow to answer directly within living matter, for the first time.Thus far, state",{"id":50,"funder":7,"programme":8,"title":51,"piName":10,"institution":52,"country":53,"year":13,"amount":54,"abstract":55},"cordis-european-research-council-award-101000936","Molecular Uptake Mechanisms controlling Plant Growth","AARHUS UNIVERSITET","DK","€1,999,910","Life on Earth is sustained by plants. Growth and development in the plant kingdom is mediated by the controlled distribution of sugars and the hormone auxin, but we still know surprisingly little about the molecular details of this essential part of fundamental plant metabolism. MUM-GROW will elucidate the molecular mechanism of sugar and auxin transmembrane transport in plants. It moves the frontiers of the field by shifting the focus to molecular studies in vitro allowing structural and bioche",{"id":57,"funder":7,"programme":8,"title":58,"piName":10,"institution":59,"country":60,"year":13,"amount":61,"abstract":62},"cordis-european-research-council-award-101001976","Enhanced quantum information processing targeting the near term","TECHNISCHE UNIVERSITAET MUENCHEN","DE","€1,398,436","Progress in the fabrication, control and readout of systems consisting of a small number of qubits has catapulted quantum computation from a primarily theoretical pursuit into the lab. With the growing availability of small and relatively noise-free devices and the imminent arrival of larger next-generation equipment, new theoretical questions are being asked about the potential of quantum computation. In particular, one may ask if quantum computing devices may yield computational benefits even ",{"id":64,"funder":7,"programme":8,"title":65,"piName":10,"institution":59,"country":60,"year":13,"amount":66,"abstract":67},"cordis-european-research-council-award-101001905","Causes and consequences of forest reorganization: Towards understanding forest change","€1,965,293","Forest ecosystems around the globe are undergoing rapid reorganization. The unabated continuation of climate change, the accelerating rate of alien species introductions, and the precipitous loss of biological diversity are altering the structure and composition of forest ecosystems. As a consequence, novel ecosystems are emerging. However, the trajectories to novelty and the consequences thereof remain widely unknown. This limits the ability of forest policy and management to counteract undesir",{"id":69,"funder":7,"programme":8,"title":70,"piName":10,"institution":59,"country":60,"year":13,"amount":71,"abstract":72},"cordis-european-research-council-award-101001145","A Philosophy of Open Science for Diverse Research Environments","€1,999,851","This project will develop an empirically grounded philosophy of Open Science [OS] that emphasises the diversity of research environments around the world and articulates the conditions under which OS can leverage such diversity to promote good research practice. The OS movement is transforming research, with OS policies adopted around the globe and widespread agreement on implementing key OS principles like openness, transparency and reproducibility. However, the philosophy of science underpinni",{"id":74,"funder":7,"programme":8,"title":75,"piName":10,"institution":59,"country":60,"year":13,"amount":76,"abstract":77},"cordis-european-research-council-award-101001591","Highly Reactive Low-valent Aluminium Complexes and their Application in Synthesis and Catalysis","€1,997,750","This ERC-CoG 2020 proposal, ALLOWE outlines a strategy for the development of low-valent aluminium systems through their synthesis, isolation, and reactivity investigation of neutral, ambiphilic, low-valent aluminium compounds, denoted “alumylenes”. Their dimeric form “dialumenes” featuring an aluminium-aluminium double bond will also be within the scope of the project. These low-valent aluminium species are expected to provide, along with greater understanding of the fundamental behaviour of lo",{"id":79,"funder":7,"programme":8,"title":80,"piName":10,"institution":81,"country":82,"year":13,"amount":83,"abstract":84},"cordis-european-research-council-award-101002225","DEEP FIELD: Seeing the Unseen in Image-guided Surgery","UNIVERSITY COLLEGE CORK -  NATIONAL UNIVERSITY OF IRELAND, CORK","IE","€2,000,000","The future of surgery will be image-guided. But how will the surgeon navigate instruments beyond the camera's field of view without using harmful x-rays? The potential of magnetic tracking to navigate surgical instruments without x-rays has long been appreciated but current technology lacks sufficient accuracy, speed, robustness and immunity to magnetic field distortion to change the clinical paradigm. DEEP FIELD will break thorough the scientific frontier in surgical navigation to make magnetic",{"id":86,"funder":7,"programme":8,"title":87,"piName":10,"institution":81,"country":82,"year":13,"amount":88,"abstract":89},"cordis-european-research-council-award-101001684","PHAGENET: PHAge GEnetic NETworking in the microbiome","€1,999,988","Horizontal gene transfer (HGT) is one of the primary forces driving rapid adaptation and long term evolution of complex microbial communities such as the human microbiome. The same process is involved in the dissemination of virulence and antimicrobial resistance genes and emergence of “superbugs”. The precise mechanisms and role of HGT in the structure and function of the microbiome remain largely unexplored.Bacteriophages are ubiquitous and highly abundant members of the human microbiome, acco",{"id":91,"funder":7,"programme":8,"title":92,"piName":10,"institution":93,"country":94,"year":13,"amount":95,"abstract":96},"cordis-european-research-council-award-101001615","Digital Protein Biophysics of Aggregation","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","UK","€1,999,715","Proteins are the fundamental building blocks of life, underpinning functional processes in living systems. They are able to exert their biological activities by binding to other proteins to form functional complexes which act as the machinery of life. In certain cases, however, proteins escape cellular quality control mechanisms and form aberrant complexes. The formation of such clusters stabilised by inter-molecular hydrogen bonds, amyloid aggregates, has dramatic consequences for biological sy",{"id":98,"funder":7,"programme":8,"title":99,"piName":10,"institution":100,"country":12,"year":13,"amount":101,"abstract":102},"cordis-european-research-council-award-101003318","Impact of Biofuels on the Oxidation Stability and Combustion Pollutants of Heavy Duty and Jet Fuels","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€1,996,856","Reducing greenhouse gas and harmful emissions in the transport sector is a crucial issue in the fight against climate change and air pollution. The use of sustainable biofuels remains the solution of choice to reduce the carbon footprint of propulsion systems that are difficult or impossible to electrify, such as those for aviation or road freight transports. The addition of biofuels to conventional fuels strongly affects their oxidation stability, leading to changes in their chemical and physic",{"id":104,"funder":7,"programme":8,"title":105,"piName":10,"institution":106,"country":53,"year":13,"amount":107,"abstract":108},"cordis-european-research-council-award-101003378","Multi-Qubit Photonic Devices","DANMARKS TEKNISKE UNIVERSITET","€2,587,745","MultiQubit is built on the concept of a novel type of quantum dots — crystal-phase quantum dots — discovered and developed by the PI. Crystal-phase quantum dots have a unique advantage — growth control with the ultimate accuracy of a single atomic layer. This advantage will break the major limitation in the field of optically-active quantum dots — impossibility to build quantum devices with multiple quantum dots due to lack of the required growth control — and thus unlock their true potential fo",{"id":110,"funder":7,"programme":8,"title":111,"piName":10,"institution":100,"country":12,"year":13,"amount":112,"abstract":113},"cordis-european-research-council-award-101001097","Lipid gradients and the dynamics of the plant endomembrane system:  from the nano- to the developmental scales","€2,374,844","Anionic lipids are critical for membrane organization and signaling in eukaryotes, including animals and plants. The dogma is that they accumulate in distinct membranes, thereby recruiting a unique set of lipid-binding proteins to each compartment. In turn, these proteins regulate trafficking and signaling activities on these compartments. However, it is increasingly recognized that anionic lipid distribution is not organelle-specific. In particular, we uncovered the presence of anionic lipids c",{"id":115,"funder":7,"programme":8,"title":116,"piName":10,"institution":100,"country":12,"year":13,"amount":117,"abstract":118},"cordis-european-research-council-award-101002644","Pollination ecology: how do bees move across the landscape and fashion plant reproduction?","€1,998,856","How pollinators, such as bees, exploit plaHow pollinators, such as bees, exploit plant resources is a fundamental question in biology, with deep ecological, economical and societal consequences. When foraging on flowers, pollinators transfer pollen and mediate the reproduction of plants on which most animals (including us humans) rely on. Understanding the spatial foraging strategies and interactions of pollinators across the landscape is thus a critical scientific challenge to discover their in",{"id":120,"funder":7,"programme":8,"title":121,"piName":10,"institution":122,"country":40,"year":13,"amount":123,"abstract":124},"cordis-european-research-council-award-101002207","Fundamental properties and time-scan of QCD matter at high densities and temperature exposed by jet substructure in heavy ion collisions with CMS experiment at the LHC","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","€1,731,406","Quantum Chromodynamics (QCD) is the theory of the strong force. Its high-temperature phase can be accessed experimentally via high energy heavy-ion collisions, allowing us to investigate how the macroscopic properties of nuclear matter arise from QCD interactions between quarks and gluons. With this proposal I aim to solve several fundamental and long-standing questions concerning the strong force and the evolution of the high density phase of QCD, the Quark Gluon plasma (QGP), that are related ",{"id":126,"funder":7,"programme":8,"title":127,"piName":10,"institution":100,"country":12,"year":13,"amount":128,"abstract":129},"cordis-european-research-council-award-101001897","The New era of EUropean CMB Cosmology with the South Pole Telescope","€1,971,587","The goal of NEUCosmoS is to unravel some of the most severe inconsistencies that are currently threatening the so-far very successful standard model of cosmology (ΛCDM). The most critical one is the steadily growing 5σ difference in the measurement of the expansion rate of the universe today, the Hubble constant, from early-time probes (CMB) versus late-time ones (supernovae Ia). Additional discrepancies persist in the amplitude of matter perturbations, σ8, and in other fundamental parameters, s",{"id":131,"funder":7,"programme":8,"title":132,"piName":10,"institution":133,"country":134,"year":13,"amount":135,"abstract":136},"cordis-european-research-council-award-101003208","Good attention: Attention norms and their role in practical reason, epistemology, and ethics","UNIVERSITETET I OSLO","NO","€1,999,997","What is good attention? Much public discussion about social media, public health, and political debates is focused on versions of this question. What deserves our attention and how we should regulate attention in the face of distraction occupies the debate. What is missing is a philosophical investigation of attention norms and a framework for thinking about them. This is what GOODATTENTION provides. While entire fields of philosophy investigate the normative assessment of other aspects of the m",{"id":138,"funder":7,"programme":8,"title":139,"piName":10,"institution":140,"country":82,"year":13,"amount":141,"abstract":142},"cordis-european-research-council-award-101001052","THEATRONOMICS: The Business of Theatres, 1732-1809","UNIVERSITY OF GALWAY","€1,997,535","Eighteenth-century literary studies has taken a ‘theatrical turn’ over the past twenty-five years and the century historically associated with the ‘rise of the novel’ now acknowledges the centrality of the theatre to Georgian cultural and political life. However, we have virtually ignored its remarkable financial archive. Account-books, ledgers, and ephemeral manuscript folios contain rich data on ticket sales, audience members, revenues, actor salaries, repayments to investors, costume, scenery",{"id":144,"funder":7,"programme":8,"title":145,"piName":10,"institution":146,"country":82,"year":13,"amount":147,"abstract":148},"cordis-european-research-council-award-101002440","Societal Attitudes to Urban Novel Ecosystems","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","€1,999,941","Novel ecosystems are unmanaged wild areas that are anthropogenic in composition and can never be restored to their original ecological status. Though relatively new, novel ecosystem theory challenges our fundamental relationships with ‘new’ nature and what this means for the future of biodiversity conservation and societal progress. This has resulted in much polarised debate among the ecology community where novel ecosystem theory is highly contested, but there has been no engagement with human ",{"id":150,"funder":7,"programme":8,"title":151,"piName":10,"institution":146,"country":82,"year":13,"amount":152,"abstract":153},"cordis-european-research-council-award-865474","A neurally-informed behavioural modeling framework for examining individual and group difference in perceptual decision making","€1,996,310","Pinpointing the mechanistic origins of inter-individual differences in decision making is a central goal of modern psychology and a considerable challenge because even elementary perceptual choices rely on a multitude of sensory, cognitive, motivational and motoric processes. For this reason, researchers have relied heavily on a set of mathematical ‘sequential sampling’ models that are designed to parse the latent psychological processes driving variations in choice behaviour. Although these mod",{"id":155,"funder":7,"programme":8,"title":156,"piName":10,"institution":157,"country":158,"year":13,"amount":83,"abstract":159},"cordis-european-research-council-award-101003229","Novel mechanisms of adaptive and innate bacteriophage immunity","TECHNISCHE UNIVERSITEIT DELFT","NL","Microbes are engaged in an evolutionary arms-race with their viruses and have evolved a spectrum of adaptive and innate defense systems to limit viral predation. Mechanistic insights into defense systems have yielded truly revolutionary genetic tools ranging from CRISPR-based genome editing nucleases to restriction enzymes used for molecular cloning. Despite the ongoing effort to understand defense systems, many antiviral defense systems remain virtually unstudied in and outside their native mic",{"id":161,"funder":7,"programme":8,"title":162,"piName":10,"institution":157,"country":158,"year":13,"amount":163,"abstract":164},"cordis-european-research-council-award-101001005","Generation and manipulation of quantum sound","€2,374,300","Quantum physics has been at the very heart of understanding the inner workings of nature and has led to the beginning of a modern technological revolution. Over the past decades, more and more physical systems have been used in quantum experiments. Yet, despite their tantalizing theoretical potential, full and comprehensive quantum control over phonons, in particular of traveling acoustic waves, has remained an elusive goal, mainly due to technical challenges. I have recently been part of the ex",{"id":166,"funder":7,"programme":8,"title":167,"piName":10,"institution":168,"country":169,"year":13,"amount":170,"abstract":171},"cordis-european-research-council-award-101002478","Engineering kidney organoids to study the interplay between Tissue Mechanics and Metabolism: from development to disease","FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA","ES","€1,999,937","Research with human pluripotent stem cells (hPSCs) has led to the development of miniorgan-like structures in culture, so called organoids. Generally, organoids are generated exploiting cell-autonomous responses of hPSCs with minimal control over the external inputs supplied to the system. The unrestrained nature of these approaches explains, in part, key shortcomings of the organoid technology, such as limited capacity to recreate all cell types within an organ, maturation and function.Data fro",{"id":173,"funder":7,"programme":8,"title":174,"piName":10,"institution":175,"country":176,"year":13,"amount":177,"abstract":178},"cordis-european-research-council-award-101003153","Facing Adiposity in personalizing Treatment  of Breast Cancer Patients","KATHOLIEKE UNIVERSITEIT LEUVEN","BE","€1,998,620","One out of 8 women develops breast cancer (BC) in her lifetime and 1 out of 2 is overweight or obese in industrialized countries. While heavier women have an increased risk of developing BC and heavier BC patients present with worse disease characteristics, BC is so far still treated regardless of patient adiposity because of the limited knowledge accumulated so far. I hypothesize that increased adiposity provides a different soil for the tumor cells (the 'seeds') to grow, potentially leading to",{"id":180,"funder":7,"programme":8,"title":181,"piName":10,"institution":182,"country":158,"year":13,"amount":183,"abstract":184},"cordis-european-research-council-award-101003134","The ghostworker's well-being: An integrative framework","UNIVERSITEIT UTRECHT","€1,958,490","Artificial intelligence depends on human labour to conduct tasks such as data cleaning, coding, and classifying content. This on-demand work is offered and performed online, paid by the task, on platforms like Amazon Mechanical Turk. Conceptualized as ‘ghost work’, this rapidly growing, platform-based work is largely unseen: workers are unable to speak with managers, do not get feedback, and lack labour protections. How do these specific work conditions influence ghost workers’ well-being? To en",{"id":186,"funder":7,"programme":8,"title":187,"piName":10,"institution":188,"country":189,"year":13,"amount":190,"abstract":191},"cordis-european-research-council-award-101001848","Intelligent Instruments: Understanding 21st-Century AI Through Creative Music Technologies","HASKOLI ISLANDS","IS","€1,999,460","Artificial Intelligence is becoming increasingly human-like and it is now proficient in a key human activity: musical creativity. But what does this mean? How does creative AI change our notions of art, culture and society? As new machine learning technologies begin to mirror ourselves, we need to look into that mirror and ask how AI is changing us. This project takes a pioneering leap in research about AI by answering how new creative AI transforms our relationships with technology and other pe",{"id":193,"funder":7,"programme":8,"title":194,"piName":10,"institution":195,"country":196,"year":13,"amount":197,"abstract":198},"cordis-european-research-council-award-101001521","Controlling Influenza A Virus Liquid Organelles","UNIVERSIDADE CATOLICA PORTUGUESA","PT","€2,870,250","The world health organization monitors viral infections worldwide with the aim to coordinate strategies to control viral outbreaks. The on-demand development of vaccines or antibody treatment does not confer a first line of defense against unpredictable infections caused by new viruses in humans such as pandemic influenza, corona or Ebola viruses, and new approaches are needed. We propose to investigate the fundamental basis of novel host-pathogen interactions in influenza A virus (IAV) infectio",{"id":200,"funder":7,"programme":8,"title":201,"piName":10,"institution":202,"country":203,"year":13,"amount":204,"abstract":205},"cordis-european-research-council-award-101001267","Microscopic Active Particles with Embodied Intelligence","GOETEBORGS UNIVERSITET","SE","€1,992,636","Over billions of years of evolution, motile organisms have developed complex strategies to survive and thrive. These strategies integrate three components: sensors, actuators, and information processing. In the last two decades, active-matter research has tried to replicate the evolutionary success of microorganisms in artificial systems. Researchers have replicated the actuators by developing artificial active particles that extract energy from their environment to perform mechanical work and, ",{"id":207,"funder":7,"programme":8,"title":208,"piName":10,"institution":209,"country":94,"year":13,"amount":210,"abstract":211},"cordis-european-research-council-award-866239","Sonic Street Technologies (SST): their diaspora and what they tell us about technology and scientific knowledge","GOLDSMITHS' COLLEGE","€1,988,710","This project claims that ‘sonic street technologies’ (SST) provide a new, productive and urgently required understanding of the social, cultural and political nature of technology. Jamaican reggae sound systems, Brazilian mobile carnival trio electrico, Mexican sonideros and Colombian los picos are examples of such ‘street’ technologies. In the global south they are played out of doors and are an essential part of popular culture. These are re-purposed, hacked, DIYed, pirated, customized and cre",{"id":213,"funder":7,"programme":8,"title":214,"piName":10,"institution":215,"country":94,"year":13,"amount":216,"abstract":217},"cordis-european-research-council-award-101003111","Cyclic Peptide Platform as an Approach to Target Validation","UNIVERSITY OF NEWCASTLE UPON TYNE","€2,241,271","The current ‘genomics’ era is an exciting time for drug target discovery with considerable opportunities for therapeutic intervention. Whilst classical small molecules remain the reagents of choice as chemical probes for target validation, not all targets are tractable with small molecules. There is thus an urgent need to develop methods for more efficient target validation, not only of individual proteins but also of protein-protein and other complexes. Natural product like cyclic peptides have",{"id":219,"funder":7,"programme":8,"title":220,"piName":10,"institution":221,"country":158,"year":13,"amount":222,"abstract":223},"cordis-european-research-council-award-101000981","Synthetic Catch Bonds","WAGENINGEN UNIVERSITY","€1,995,060","All primary chemical bonds, covalent and supramolecular, weaken under tension. This imposes fundamental limits on the mechanical stability of molecules and their materials. Nature has evolved to secondary bonds that break through these limits and strengthen under tension. These so-called catch bonds, which know no synthetic equivalent to date, are used in Nature as a rule, rather than exception, in scenarios where supramolecular bonds are exposed to large stresses.   This change in the fundament",{"id":225,"funder":7,"programme":8,"title":226,"piName":10,"institution":227,"country":40,"year":13,"amount":228,"abstract":229},"cordis-european-research-council-award-101002084","Migrating commercial law and language. Rethinking lex mercatoria (11th-17th century)","UNIVERSITA DEGLI STUDI DI PADOVA","€1,610,593","MICOLL will analyze the development of commercial law by means of a tool almost ignored in this field: historical linguistics. The borrowing and transfer of legal terms will be carried out through a comprehensive and systematic investigation of medieval and early modern legal sources, in particular commercial letters, contracts and statutes. Even though legal historians tend to deny the effectiveness of a body of customary laws uniformly adopted across medieval and modern Europe, the “myth” of t",{"id":231,"funder":7,"programme":8,"title":232,"piName":10,"institution":233,"country":40,"year":13,"amount":234,"abstract":235},"cordis-european-research-council-award-101002163","Managing Identities in Diverse Societies: A Developmental Intergroup Perspective with Adolescents","ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA","€1,990,015","Ethnic and cultural diversity has sharply increased in modern societies due to migration processes. However, the implication of this for adolescents facing the core task of developing their identities are still mostly unknown. For both adolescents without and with a migrant background (e.g., recent refugees, second-generation immigrants) growing up in societies with increasing levels of diversity can be challenging, as they have to manage their identities acknowledging that how they address the ",{"id":237,"funder":7,"programme":8,"title":238,"piName":10,"institution":233,"country":40,"year":13,"amount":239,"abstract":240},"cordis-european-research-council-award-864045","Deep Serpentinization, H2, and high-pressure abiotic CH4","€2,474,368","The deep subsurface biosphere is the largest microbiological habitat on Earth, with biomass and contribution to biogeochemical cycles comparable to surface biosphere. Deciphering the parameters that control and sustain deep subsurface life is vital in understanding the functioning of our planet, and additionally provides key information on how life emerged and where it could exist elsewhere. Among these parameters are the sources of essential energy for deep life, such as H2 and CH4. Great effor",{"id":242,"funder":7,"programme":8,"title":243,"piName":10,"institution":244,"country":245,"year":13,"amount":246,"abstract":247},"cordis-european-research-council-award-101001290","Three-dimensional nanoscale magnetic structures","TECHNISCHE UNIVERSITAET WIEN","AT","€2,603,096","Three-dimensional (3D) nanomagnets, with unconventional spin and topological properties, are very promising systems for the future development of greener, more capable, multi-functional technologies. However, the significant experimental challenges associated with the fabrication and probing of 3D nanoscale geometries and spin configurations, have restricted most studies to date in this field, to either computational and theoretical works, or experiments in simple 3D geometries that do not fully",{"id":249,"funder":7,"programme":8,"title":250,"piName":10,"institution":251,"country":169,"year":13,"amount":10,"abstract":252},"cordis-european-research-council-award-101001916","Interrogating Human Adult Hippocampal Neurogenesis","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","The hippocampus is crucial for learning and memory and it hosts an extraordinary form of plasticity: the generation of new neurons throughout life, a process named adult hippocampal neurogenesis (AHN). Newly generated neurons grow in a specialised niche composed of unique vascular, glial, and neuronal elements. Impaired AHN leads to cognitive dysfunction and mood dysregulation in rodents. Recent work by my group reveals the persistence of AHN until the tenth decade of human life, as well as impa",{"id":254,"funder":7,"programme":8,"title":255,"piName":10,"institution":251,"country":169,"year":13,"amount":256,"abstract":257},"cordis-european-research-council-award-101001732","Understanding the Energy Transition with a Machine Learning Toolbox","€1,679,125","The goal of this proposal is to build tools to better understand the economic impacts of the rapid transformation of electricity markets, and to help better design electricity markets going forward. I propose to develop and implement novel statistical tools and structural models that contribute to our understanding of this rapid transformation. The proposed research focuses both on firm strategic responses and investment (supply-side), as well as consumer behavior and welfare and distributional ",{"id":259,"funder":7,"programme":8,"title":260,"piName":10,"institution":251,"country":169,"year":13,"amount":261,"abstract":262},"cordis-european-research-council-award-862342","Analysis of geometry-driven phenomena in fluid mechanics, PDEs and spectral theory","€1,825,163","This project aims to go significantly beyond the state of the art in several fundamental questions in PDEs with a clear geometric flavor. Central to this proposal is the Euler equation for an incompressible fluid, where the topics that I will be concerned with range from free boundary problems where I will strive to prove that the curvature of the interface blows up in finite time due to the appearance of kinks of controlled geometry, to the existence of smooth stationary solutions that feature ",{"id":264,"funder":7,"programme":8,"title":265,"piName":10,"institution":266,"country":94,"year":13,"amount":267,"abstract":268},"cordis-european-research-council-award-101002587","Understanding mortality: Biosocial determinants across cohorts, time and place","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€1,999,342","The aim of MORTAL is to challenge current non-empirical narratives and produce fundamentally new knowledge of mechanisms underlying mortality trends. The health and longevity of a population is a key barometer of overall welfare, reflecting the cumulative effects of the broader social, economic, and environmental conditions in which people live. Recently, demographic alarm bells have sounded as life expectancy has fallen in the U.S. and mortality improvements in the UK and other parts of Europe ",{"id":270,"funder":7,"programme":8,"title":271,"piName":10,"institution":266,"country":94,"year":13,"amount":272,"abstract":273},"cordis-european-research-council-award-101001320","Synthetic Oxygen-related molecular Systems in plants","€1,999,995","Aerobic organisms developed systems to measure cellular oxygen levels and activAerobic organisms developed systems to measure cellular oxygen levels and activate adaptive responses in case hypoxia occurs. This condition can be caused by sudden environmental changes or associated with developmental programmes. Recent reports have revealed that complex eukaryotes, such as plants and animals, converged towards the recruitment of dioxygenase enzymes to regulate gene targets at the transcriptional le",{"id":275,"funder":7,"programme":8,"title":276,"piName":10,"institution":266,"country":94,"year":13,"amount":277,"abstract":278},"cordis-european-research-council-award-101001346","The Electrolytic Revolution: Harnessing Coulomb Physics and Soft Matter Chemistry to Design Electrolyte Materials","€1,996,357","Electrolytes fill our natural environment and are crucial to many areas of modern technology. Animals and plants are made up of electrolyte and our oceans are enormous reservoirs of electrolyte covering 2\u002F3 of the surface of the Earth. Energy storage and conversion technologies, such as batteries and fuel cells, incorporate electrolyte as a central and essential ingredient. Despite this enormous ubiquity and importance of electrolytes, these fluids are often relegated to the ‘background’, consid",{"id":280,"funder":7,"programme":8,"title":281,"piName":10,"institution":266,"country":94,"year":13,"amount":282,"abstract":283},"cordis-european-research-council-award-101001623","Paleovirology, the evolutionary dynamics of viral cross-species transmissions, and the consequences of virus-host gene exchange","€1,999,805","Viruses are ubiquitous, obligate intracellular parasites that have had a pervasive influence on the evolutionary history of life. Despite being extensively studied due to their role in disease, very little is known about their long-term evolution, since they do not form a geological fossil record. The new field of paleovirology is the study of ancient viruses, which in the genomic age has been facilitated by discoveries of endogenous viral elements (EVEs). EVEs are the remnants of viruses that h",{"id":285,"funder":7,"programme":8,"title":286,"piName":10,"institution":266,"country":94,"year":13,"amount":287,"abstract":288},"cordis-european-research-council-award-101001717","Moving Stories: Sectarianisms in the Global Middle East","€1,999,482","The emergence of sectarianism forms a key element of the impact of modernization and globalization on Middle Eastern history. Yet we still lack a full picture of how new forms of sectarianism developed within the region, and in exile, and how these sectarianisms became such a powerful force in the volatile history of a decolonizing Middle East. The Moving Stories project concentrates on two areas of research. First, the project will explore the global circulation of Middle Eastern sectarianism a",{"id":290,"funder":7,"programme":8,"title":291,"piName":10,"institution":292,"country":134,"year":13,"amount":293,"abstract":294},"cordis-european-research-council-award-101001957","Fluid Inclusion Microthermometry in Speleothems","UNIVERSITETET I BERGEN","€1,999,634","Ongoing global warming is rapidly moving us away from the climate states we are used to and understand from observational time series. This poses the urgent need to extend our “climate memory” by deciphering climate information stored in geologic archives. However, obtaining quantitative estimates for past climate changes is challenging, particularly in terrestrial archives due to common limitations in time coverage, resolution, and chronology. FluidMICS will employ a novel technique to reconstr",{"id":296,"funder":7,"programme":8,"title":297,"piName":10,"institution":251,"country":169,"year":13,"amount":298,"abstract":299},"cordis-european-research-council-award-101002203","Regulatory rules and evolution of neuronal gene expression","€1,997,500","Complex brain functions require a remarkable degree of cellular specialization. Understanding the mechanisms guiding neuronal specification programs remains a major challenge. Here we use the nematode C. elegans, an essential animal model for studying the general principles of neuron specification, to provide answers to four fundamental questions: 1) How are regulatory landscapes coordinately activated in each type of neuron? We previously showed that complex combinations of transcription factor",{"id":301,"funder":7,"programme":8,"title":302,"piName":10,"institution":266,"country":94,"year":13,"amount":303,"abstract":304},"cordis-european-research-council-award-865624","Overcoming stellar activity in radial velocity planet searches","€1,999,833","Radial velocity (RV) planet searches are a key exoplanet detection method, and one of the only ways to measure a planet's mass. The best RV instruments today reach precisions well below 1 m\u002Fs, something which would have seemed impossible 30 years ago. The key factor limiting the sensitivity of RV surveys now is stellar activity. Regions of enhanced magnetic flux on the stellar surface alter the shape of absorption lines in the stellar spectrum, and perturb the measured RVs. I have developed phys",{"id":306,"funder":7,"programme":8,"title":307,"piName":10,"institution":308,"country":60,"year":13,"amount":309,"abstract":310},"cordis-european-research-council-award-101001561","LIfetime measurements with Solid Active targets","GSI HELMHOLTZZENTRUM FUR SCHWERIONENFORSCHUNG GMBH","€1,996,250","The coexistence of single-particle and collective degrees of freedom in atomic nuclei gives rise to various exotic phenomena. In nuclei with very asymmetric proton-to-neutron ratios, the strong nuclear interaction drives shell evolution which alters the orbital spacing, and in some cases even the ordering present in stable nuclei. In the absence of large gaps between orbitals, nuclei can take on non-spherical shapes and their excitations proceed through coherent and collective motion of many nuc",{"id":312,"funder":7,"programme":8,"title":313,"piName":10,"institution":251,"country":169,"year":13,"amount":314,"abstract":315},"cordis-european-research-council-award-101001038","Reconnecting transmission to global tuberculosis control by mapping pathogen transmission events to host infection status","€2,723,027","The annual decline in tuberculosis (TB) incidence is not greatly different from that of the ‘90s, when no coordinated efforts in global tuberculosis control were in place. The failure of current TB control programmes to accelerate TB elimination has multiple causes, including losses of TB cases at the different steps of the TB care cascade, and a chronic lack of funding hampering innovation. Additionally, we have failed to halt transmission in many settings, as we have failed to incorporate our ",{"id":317,"funder":7,"programme":8,"title":318,"piName":10,"institution":319,"country":60,"year":13,"amount":320,"abstract":321},"cordis-european-research-council-award-101001899","Reinventing Energy Efficiency in Communication Networks","KARLSRUHER INSTITUT FUER TECHNOLOGIE","€1,999,835","To this day, communications engineering has closely followed the seminal guidelines developed by Claude E. Shannon in 1948, which were mostly influenced by the telephone network of those days. The widespread use of mobile communications and the advent of machine-to-machine communications nowadays entail an exponential increase in data rates and the available models are no longer sufficient to design power-efficient, low-latency, high-speed communication systems. The overarching aim of RENEW is t",{"id":323,"funder":7,"programme":8,"title":324,"piName":10,"institution":319,"country":60,"year":13,"amount":325,"abstract":326},"cordis-european-research-council-award-101003292","ACTINIDE BOND properties in gas, liquid and solid state","€1,999,915","Understanding the electronic structure and chemical bonding properties of the early actinide (An) elements (Th-Cm) poses a great challenge and frontier in fundamental chemistry and physics. I aim to clarify the link between covalency and strength of the chemical bond of the early An elements from Th to Cm in gas, liquid and solid state materials - combining innovative high challenge experimental setups, advanced synchrotron based spectroscopy methods and state-of-the-art quantum chemical computa",{"id":328,"funder":7,"programme":8,"title":329,"piName":10,"institution":330,"country":60,"year":13,"amount":331,"abstract":332},"cordis-european-research-council-award-101002646","Genetically encoded reporters and sensors for whole animal imaging using photo-modulated Optoacoustics","HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH","€1,992,997","In vivo imaging of cellular localization and function and visualization of the chemicals that drive life are key challenges for biological research. Current methods limit our insight into this “bigger picture” to either a glimpse (low penetration and small field of view) or a coarse overview (low resolution).Optoacoustic (OA) imaging has the physical means to overcome these limitations, but it lacks the necessary toolbox of genetically encoded reporters and sensors that allow specific probing of",{"id":334,"funder":7,"programme":8,"title":335,"piName":10,"institution":330,"country":60,"year":13,"amount":336,"abstract":337},"cordis-european-research-council-award-865323","Translational aspects of the discovery of skull marrow – meninges connections","€1,996,900","Neurodegenerative diseases (NDs) are labeled as the epidemic of the 21st century. The inflammation of the brain is a common pathology observed in many NDs. Here I aim to exploit our discovery of skull – meninges connections (SMCs) mediating immune cell trafficking into the brain to ease this healthcare burden. Using tissue clearing methods, we found that the skull (calvaria) bone marrow is directly connected to the brain meninges, a discovery that was also shown by an independent group around th",{"id":339,"funder":7,"programme":8,"title":340,"piName":10,"institution":330,"country":60,"year":13,"amount":341,"abstract":342},"cordis-european-research-council-award-101002247","Weight Maintenance by AgRP neurons","€1,999,976","Obesity and its comorbid sequelae are major health burdens across European nations. Many citizens would greatly benefit from permanent weight loss, but only a few succeed. They rather suffer from weight regain after dieting, often referred to as Yoyo effect. Delineating the largely unexplored, CNS-driven molecular events that impede sustainable weight loss and drive the Yoyo effect is a prerequisite for future therapies, and a major goal of my proposal.Recently, my lab demonstrated unprecedented",{"id":344,"funder":7,"programme":8,"title":345,"piName":10,"institution":346,"country":12,"year":13,"amount":347,"abstract":348},"cordis-european-research-council-award-101001995","Fast and Reliable Symbolic Computation","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","€1,999,926","The use of computers for formulating conjectures, but also for substantiating proof steps, pervades mathematics, even in its most abstract fields. Most computer proofs are produced by symbolic computations, using computer algebra systems. Sadly, these systems suffer from severe, intrinsic flaws, key to their amazing efficiency, but preventing any flavor of post-hoc verification.But can computer algebra become reliable while remaining fast? Bringing a positive answer to this question represents a",{"id":350,"funder":7,"programme":8,"title":351,"piName":10,"institution":227,"country":40,"year":13,"amount":352,"abstract":353},"cordis-european-research-council-award-101001839","GEOarchaeology of DAily Practices: extracting bronze age lifeways from the domestic stratigraphic record","€1,987,141","What was daily life like in the European Bronze Age? In contrast to large-scale narratives based on artefacts, often prestige items from funerary contexts, this project focuses on the practices of daily domestic life, recorded in the sediments upon which it took place. These constitute the domestic stratigraphic record. This project, therefore, shifts the scale and the object of archaeological investigation, and aims at bringing interdisciplinary scientific analyses into dialogue with anthropolo",{"id":355,"funder":7,"programme":8,"title":356,"piName":10,"institution":100,"country":12,"year":13,"amount":357,"abstract":358},"cordis-european-research-council-award-865629","Bioinorganic intracellular synthesis of photo-responsive bio-camouflaged nanomedicines","€1,967,000","Exposed to smart man-engineered nanomedicines, cells can profoundly transform and recycle them. To communicate, or in response to exogenous stress, cells generate extracellular vesicles which can play crucial roles in multiple physiological processes, as for instance, and unfortunately, for cancer progression. The goal of this proposal is to combine both biological events to deliver nanomedicines created by cells only, using mesenchymal stem cells as the most relevant cell model.The focus of thi",{"id":360,"funder":7,"programme":8,"title":361,"piName":10,"institution":362,"country":12,"year":13,"amount":363,"abstract":364},"cordis-european-research-council-award-101001689","Formation, magmatic evolution and present-day structure of the CRUsts of Stagnant-LID planets","ECOLE NORMALE SUPERIEURE DE LYON","€1,606,031","The low density of the Earth’s continental crust has been proposed to be at the origin of plate tectonics. Physical studies on the continental crust have shown that its low density was acquired by differentiation of the crust and loss of dense mafic residues. What is the composition and vertical structure of the crusts of the other terrestrial planets, which do not show plate tectonics? How did they form and what are the modifications they have undergone following their formations? Are they far ",{"id":366,"funder":7,"programme":8,"title":367,"piName":10,"institution":368,"country":12,"year":13,"amount":369,"abstract":370},"cordis-european-research-council-award-101002857","Structural damage: robust, real-time, and data-driven adaptive modeling for online control","ECOLE NORMALE SUPERIEURE PARIS-SACLAY","€1,937,500","Diagnosing structural damage and predicting its evolution has been a perpetual engineering issue. It is nowadays the topic of intensive research works addressing online damage detection and control, and benefiting from experimental and numerical advances made during the last decad. On the one hand, embedded sensor technologies nowadays provide high-resolution in situ information on the internal damage state of materials. On the other hand, the booming development of virtual twins and artificial ",{"id":372,"funder":7,"programme":8,"title":373,"piName":10,"institution":100,"country":12,"year":13,"amount":374,"abstract":375},"cordis-european-research-council-award-101001474","Motivic Cohomology of Schemes","€1,635,650","The project belongs to the field of arithmetic algebraic geometry and is centred around algebraic K-theory, motivic cohomology, and topological cyclic homology. The overall goal is to develop a general theory of motivic cohomology for arbitrary schemes, extending the existing theory of Bloch, Levine, Suslin, Voevodsky, and others in the special case of smooth algebraic varieties. This will describe non-connective algebraic K-theory via an Atiyah--Hirzebruch spectral sequence. The project relies ",{"id":377,"funder":7,"programme":8,"title":378,"piName":10,"institution":100,"country":12,"year":13,"amount":379,"abstract":380},"cordis-european-research-council-award-101002955","Light-Control of Nonequilibrium Quantum Matter","€1,994,183","Recent experimental developments across fields such as ultra-fast science, condensed matter  and quantum optics have turned the electromagnetic radiation from traditional spectroscopic probe into a powerful tool to control and manipulate quantum materials and devices. A striking example is provided by light-induced superconductivity, observed in a number of compounds ranging from cuprates to fullerides and, more recently, organic materials, at temperatures far higher than in thermal equilibrium.",{"id":382,"funder":7,"programme":8,"title":383,"piName":10,"institution":384,"country":60,"year":13,"amount":385,"abstract":386},"cordis-european-research-council-award-864038","The evolution and regulation of major transitions in sexual systems: new insights from the brown algae","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€1,999,420","Sexual reproduction is a pervasive phenomenon that produces new genetic combinations in nearly all eukaryotic lineages. Whilst the core processes that define meiotic sex (meiosis and syngamy) are universal, sex determination systems are not evolutionary conserved but are bewilderingly diverse and have had rapid turnover rates during evolution. Transitions among sex determination systems have profound evolutionary and ecological consequences, but our understanding of the mechanisms, ultimate caus",{"id":388,"funder":7,"programme":8,"title":389,"piName":10,"institution":100,"country":12,"year":13,"amount":390,"abstract":391},"cordis-european-research-council-award-865711","Waves and concentration dynamics in biology","€1,378,588","Biology is a source of exciting mathematical challenges. Likewise, there is a strong demand from biologists for rationalizing and quantifying their fascinating observations and for testing hypotheses via theoretical models. PDE have proven powerful for these purposes. The main goal of the WACONDY project is to expand the theory of Hamilton-Jacobi (HJ) equations and related ones to encompass recent investigations in ecological and evolutionary dynamics. The asymptotic analysis of wave propagation",{"id":393,"funder":7,"programme":8,"title":394,"piName":10,"institution":100,"country":12,"year":13,"amount":10,"abstract":395},"cordis-european-research-council-award-101001275","Are microbes the ultimate drivers of subsurface weathering? Rates, actors, mechanisms and nanoscale imprints of the bioweathering of fresh and aged silicates","The ambition of this proposal is to provide the very first realistic assessment of the contribution of microbes to subsurface silicate weathering rates. The motivation is simple: ~70% of Earth’s bacteria and archaea live underground, and microbes have long been suspected to impact silicate weathering rates, which affect the Earth’s climate. However, the rates and mechanisms of silicate bioweathering essentially remain a terra incognita, particularly in basalt settings. Such environments are sugg",{"id":397,"funder":7,"programme":8,"title":398,"piName":10,"institution":399,"country":94,"year":13,"amount":400,"abstract":401},"cordis-european-research-council-award-101001464","CHILDREN AND GENDER INEQUALITY","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","€1,800,510","Women continue to face large and persistent drops in terms of all labor market outcomes at the arrival of children. Researchers now understand that these “child penalties” on women may account for a substantial fraction of the large level of gender inequality that persists in the labor market in all developed nations. But the mapping that goes from children to gender inequality and welfare still remains mostly unchartered. First, research has only been able to identify the effect of children onc",{"id":403,"funder":7,"programme":8,"title":404,"piName":10,"institution":100,"country":12,"year":13,"amount":405,"abstract":406},"cordis-european-research-council-award-101002721","Marine Ecosystems, Animal Resources and Human Strategies in Ancient Mediterranean: Integrated Studies on Natural and Societal Resilience","€1,974,161","Facing todays radical deterioration of marine ecosystems, marine historical ecology has a pivotal role in measuring the impacts of past environmental and human pressures on marine biodiversity, with the aim of understanding the resilience of socio-ecosystems and proposing a sustainable management of marine resources. Recent studies confirm that human groups begun fishing down the food web earlier than previously believed. The Mediterranean, this palimpsest landscape, offers a unique archive of u",{"id":408,"funder":7,"programme":8,"title":409,"piName":10,"institution":410,"country":94,"year":13,"amount":411,"abstract":412},"cordis-european-research-council-award-101002742","Efficient  Proofs and Computation: A Unified Algebraic Approach","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€1,899,675","Computational complexity lies at the heart of information and computer science. Its aim is to formally understand the boundary between problems that can be solved efficiently and those that cannot. This has many applications: new algorithms are important to make progress in domains such as machine learning and optimization, and new complexity lower bounds (namely, computational impossibility results) are essential to provably secure cryptography. Beyond practical applications, these questions re",{"id":414,"funder":7,"programme":8,"title":415,"piName":10,"institution":410,"country":94,"year":13,"amount":416,"abstract":417},"cordis-european-research-council-award-866402","Electrochemical scission of dinitrogen under ambient conditions","€2,744,880","Present ammonia synthesis, via the Haber-Bosch process, occurs in centralised facilities above 150 bar and above 400 C; it consumes a colossal 1% of our global fossil fuel consumption. Electrolytic ammonia synthesis, i.e. below 100 C and at atmospheric pressures, could be far more attractive: it would be powered by renewable energy and would take place at the point-of-consumption.   I have recently made a breakthrough, by demonstrating the first  unambiguous and quantitative evidence that dinitr",{"id":419,"funder":7,"programme":8,"title":420,"piName":10,"institution":410,"country":94,"year":13,"amount":83,"abstract":421},"cordis-european-research-council-award-101001071","Recycling Environmentally Persistent Fluorocarbons with Metathesis and Shuttle Catalysis","Fluorine containing molecules and materials improve our quality of life. For example, fluorinated gases are used as refrigerants in the automotive sector, while fluorine containing polymers such as Teflon are common in households. Fluorine is also important for drug discovery and agrochemicals. For all its advantages, the fluorochemicals industry is unsustainable. Nearly all fluorine containing molecules on our planet are synthetic and single use. At the end of their lifetime they are either des",{"id":423,"funder":7,"programme":8,"title":424,"piName":10,"institution":100,"country":12,"year":13,"amount":425,"abstract":426},"cordis-european-research-council-award-101001310","SUPERinductance for hardware-PROTECTED superconducting qubits","€2,132,595","The quantum computer dream is driven by promises of unprecedented capabilities but is also facing a stark reality: quantum coherence is as powerful as it is difficult to protect. Quantum Error Correction (QEC) aims to extend coherence using redundancies but leads to solutions that are extremely resource-intensive: at present, protecting one bit of information requires at least ten thousand physical qubits. The main objective of this proposal is to engineer a new type of superconducting qubit, wh",{"id":428,"funder":7,"programme":8,"title":429,"piName":10,"institution":100,"country":12,"year":13,"amount":430,"abstract":431},"cordis-european-research-council-award-101001095","Experience Effects on early language acquisition","€2,007,023","To what extent does experience affect child language acquisition? Answering this is crucial for our understanding of human cognition, but current evidence is insufficient because causal links between experience and outcomes cannot be established with typical approaches. We will study how the speech infants hear affects their learning of the sounds and structures of their native language, as represented in the speech the same infants produce, using an innovative and ecological technique: Audio-re",{"id":433,"funder":7,"programme":8,"title":434,"piName":10,"institution":100,"country":12,"year":13,"amount":435,"abstract":436},"cordis-european-research-council-award-101001675","Origin and evolution of intracellular symbioses in plants","€1,996,027","Mutualism between plants and microorganisms has been essential for the evolution of terrestrial ecosystems for millions of years. It has been proposed that even the colonization of lands by plants was facilitated by a mutualistic symbiosis formed with arbuscular mycorrhizal fungi. This symbiosis, by far the most widespread in land plants, results in the accommodation of the symbiotic fungus inside the plant cells. Following this initial symbiosis, multiple other intracellular symbioses have evol",{"id":438,"funder":7,"programme":8,"title":439,"piName":10,"institution":100,"country":12,"year":13,"amount":440,"abstract":441},"cordis-european-research-council-award-865856","In Blockchain We Trust(Less):  The Future of Distributed Governance","€1,997,000","The general malaise of liberal democracies—characterized by a gradual erosion of trust in traditional institutions (such as banks) and new intermediaries (e.g. social media)—has spurred the development of new blockchain-based applications (like Bitcoin) that allegedly obviate the need for trust. Often described as a “trustless” technology, blockchain’s potential for disintermediation has been touted as a catalyst of innovation that could displace existing power structures. But is it shifting pow",{"id":443,"funder":7,"programme":8,"title":444,"piName":10,"institution":445,"country":60,"year":13,"amount":446,"abstract":447},"cordis-european-research-council-award-101001991","Understanding Late Antique Top-Down Communication: a Study of Imperial Constitutions","OTTO-FRIEDRICH-UNIVERSITAET BAMBERG","€1,998,625","The genre of late antique law texts, “constitutions”, appears puzzling to the modern observer: contrary to our expectations of clarity and brevity, they are astoundingly voluminous, hiding away the actual legal core—which can be quite short—in a lengthy and elaborate text. They are composed in an accomplished style, and we actually know that their authorship was entrusted to some of the best contemporary literati. Thanks to a sophisticated system of transmission, these texts would reach each and",{"id":449,"funder":7,"programme":8,"title":450,"piName":10,"institution":451,"country":53,"year":13,"amount":452,"abstract":453},"cordis-european-research-council-award-101002208","The biofilm matrix and its functional role in the ecology of bacterial communities","KOBENHAVNS UNIVERSITET","€1,978,602","Complex microbial communities are comprised of diverse, interacting species. Often, such interactions result in outcomes that cannot be predicted from studies of their individual components in isolation. However, the underlying mechanisms resulting in such community intrinsic properties remain unidentified. The overarching aim of BioMatrix is to identify the molecular mechanisms underpinning community intrinsic properties of bacterial communities.In nature, bacterial communities are predominantl",{"id":455,"funder":7,"programme":8,"title":456,"piName":10,"institution":202,"country":203,"year":13,"amount":457,"abstract":458},"cordis-european-research-council-award-101003026","Evolution and mechanisms of thermal performance – answers through artificial selection in zebrafish","€1,999,087","Abstract Climate change is warming waters globally. Ectothermic animals, such as fish, have the same body temperature as the surrounding water and are therefore thought to be particularly sensitive to warming. To predict climate change impacts on fish populations, we must first know how fish are affected and how rapidly evolution may help mitigate some of those impacts.   Some of the most central questions regarding thermal acclimation and adaptation of ectothermic animals remain unresolved: 1. ",{"id":460,"funder":7,"programme":8,"title":461,"piName":10,"institution":462,"country":158,"year":13,"amount":463,"abstract":464},"cordis-european-research-council-award-101001965","Modulating ice nucleation and growth with bio-inspired protein-polymers for cryopreservation","TECHNISCHE UNIVERSITEIT EINDHOVEN","€1,999,535","Efficient, non-toxic cryoprotectants, that allow long-term storage of viable therapeutic cells and tissues, are the tool that regenerative medicine requires for its successful realization into a viable therapeutic option. A remarkable class of biopolymers known as ice-binding proteins (IBPs) alleviate the risk of freeze injury throughout the Kingdoms of Life by keeping the nucleation and growth of ice crystals in check. Yet, the application potential of IBP analogues (IBPAs) as cryoprotectants h",{"id":466,"funder":7,"programme":8,"title":467,"piName":10,"institution":468,"country":169,"year":13,"amount":83,"abstract":469},"cordis-european-research-council-award-101002715","Selective Pathways for Carbon-Nitrogen Bond Cleavage","UNIVERSIDAD AUTONOMA DE MADRID","Amines are ubiquitous across natural products, pharmaceuticals, polymers and biomolecules. The number of commercially available amines, from simple to complex, makes them one of the most accessible native functional groups. Therefore, they represent an attractive feedstock for the preparation of functionalized molecules through C-N bond activation. Nature long ago developed protocols to promote oxidative deamination reactions. Inspired by this approach, SCAN (Selective Pathways for CArbon-Nitrog",{"id":471,"funder":7,"programme":8,"title":472,"piName":10,"institution":473,"country":474,"year":13,"amount":475,"abstract":476},"cordis-european-research-council-award-866236","Imaging phase transitions in quantum materials","BAR ILAN UNIVERSITY","IL","€2,052,739","Strongly interacting electron systems lead to a wealth of competing phases, phase transitions, and quantum critical points. When probed globally, the inherent inhomogeneities, disorder, localization, and mixture with other phases can be a stumbling block in detecting and controlling the various electronic states. Armed with a suitable local probe, however, spatial inhomogeneities turn from a concealing factor into the key to unveil new exotic electronic phases. Our unique tool, the scanning SQUI",{"id":478,"funder":7,"programme":8,"title":479,"piName":10,"institution":480,"country":60,"year":13,"amount":481,"abstract":482},"cordis-european-research-council-award-101001250","Sensation and inferences in perception, metacognition and action","PHILIPPS UNIVERSITAET MARBURG","€1,996,738","The perceptual experience of humans is seamless, although there are major spatial gaps in the available sensory information due to internal (e.g. absence of photoreceptors in the blind-spot) or external reasons (e.g. occlusion by other objects). While the contents of these sensory gaps seem to be completed by inferences, it is unknown how those inferences are dealt with in further processing compared to veridical sensory information. Recently, we and others showed that inferred information is pr",{"id":484,"funder":7,"programme":8,"title":485,"piName":10,"institution":486,"country":245,"year":13,"amount":487,"abstract":488},"cordis-european-research-council-award-101001964","Engineering a Trustworthy Society: The Evolution, Perception and Impact of China’s Social Credit System","UNIVERSITAT WIEN","€1,887,444","The Chinese Social Credit System (SCS) is an ambitious social engineering scheme of an unprecedented nature. It collects information from commercial, legal and social spheres; integrates this data into a centralised platform; and establishes reputations to steer the behaviour of individuals and organisations through incentives and sanctions. The SCS ties in with global discussions on information collection, governance and authoritarian rule. It is of major significance for European interests. Em",{"id":490,"funder":7,"programme":8,"title":491,"piName":10,"institution":492,"country":169,"year":13,"amount":493,"abstract":494},"cordis-european-research-council-award-101001814","Understanding and modulating vascular arrest  with ultra-high definition","CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)","€1,998,500","Therapeutic modulation of vascular cell proliferation and migration is essential for the effective inhibition of angiogenesis in cancer or its induction in cardiovascular disease. The current view is that an increase in growth factor levels or mitogenic stimulation is beneficial for angiogenesis, since it leads to an increase in both endothelial proliferation and sprouting. Through the use of innovative genetic and imaging approaches, we have recently elucidated a previously unappreciated, conte",{"id":496,"funder":7,"programme":8,"title":497,"piName":10,"institution":498,"country":474,"year":13,"amount":499,"abstract":500},"cordis-european-research-council-award-101002406","Ultra-adaptive holographic computational imaging for seeing through random scatter, fibers, and around corners","THE HEBREW UNIVERSITY OF JERUSALEM","€1,999,875","Optical imaging systems play an instrumental role in our modern life, from smartphones and automotive cameras to microscopes that are critical for clinical diagnostics. However, the penetration depth of even the most advanced systems is still unbearably limited by the inherent random scattering of light in complex samples. Examples span many applicative fields, including scattering in tissues and fog, limiting microscopes and laser-based systems. For decades, the notion of correcting scattering ",{"id":502,"funder":7,"programme":8,"title":503,"piName":10,"institution":384,"country":60,"year":13,"amount":504,"abstract":505},"cordis-european-research-council-award-101003349","A Semantic Foundation for Persistent Programming","€1,999,300","Non-volatile memory (NVM) is an emerging technology that provides orders of magnitude faster access to persistent storage (which preserves its contents after a crash or a power failure) than hard disks. While NVM is expected to radically change how we manage storage in applications, its programming model is standing on very shaky foundations.The persistency semantics of the mainstream architectures is very unclear and full of counterintuitive behaviours. As a result, writing correct NVM programs",{"id":507,"funder":7,"programme":8,"title":508,"piName":10,"institution":486,"country":245,"year":13,"amount":509,"abstract":510},"cordis-european-research-council-award-101002816","Poetry Off the Page:  Literary History and the Spoken Word, 1965-2020","€1,898,233","Poetry Off the Page (PoP) will reveal an alternative ‘literary’ history of the period 1965-2020 by shifting the focus from the written to the spoken word. It will launch a new interdisciplinary methodology for studying poetry’s oral mode and firmly establish poetry performance research as a global discipline. Its central question is how spoken-word poetry’s semantics of presence and embodiment have shaped the “meaning” and functions of poetry, within and across national boundaries. PoP acknowled",{"id":512,"funder":7,"programme":8,"title":513,"piName":10,"institution":93,"country":94,"year":13,"amount":514,"abstract":515},"cordis-european-research-council-award-865958","Automated Verification of Textual Claims","€1,982,824","Verification of textual claims is the task of assessing the truthfulness of a statement in natural language. It is commonly conducted manually by journalists on claims made by public figures such as politicians, with the aim of reducing misinformation. However, the proliferation of social media has created the need to apply verification to a larger volume of claims coming from a greater variety of sources, thus calling for automation.Research in automated verification of textual claims is at an ",{"id":517,"funder":7,"programme":8,"title":518,"piName":10,"institution":519,"country":196,"year":13,"amount":520,"abstract":521},"cordis-european-research-council-award-101003187","Challenging current models of valence encoding  in the mammalian brain","UNIVERSIDADE DO MINHO","€1,988,266","In an ever-changing environment, organisms evolved to filter information and focus on stimuli that are associated with relevant outcomes. Even the simplest animals assign valence to otherwise neutral stimuli in order to survive. A positive (rewarding) valence stimulus elicits approach, whereas a negative (aversive) valence stimulus supports avoidance behaviors. Decades of research revealed that some regions of the limbic system encode valence, including the nucleus accumbens (NAc), which is cons",{"id":523,"funder":7,"programme":8,"title":524,"piName":10,"institution":525,"country":60,"year":13,"amount":526,"abstract":527},"cordis-european-research-council-award-101002085","Engineering perennial barley","HEINRICH-HEINE-UNIVERSITAET DUESSELDORF","€1,981,251","Today, annual crops account for more than 85% of the worldwide calorie consumption. Annual crops are sown and harvested within one growing season and therefore require annual tillage, and application of herbicides and fertilizers that cause land and water degradation. In contrast, perennial crops grow over many seasons, require low agricultural input and thereby hold great potential for sustainable production systems and climate change adaptation. However, current efforts to breed perennial cere",{"id":529,"funder":7,"programme":8,"title":530,"piName":10,"institution":531,"country":40,"year":13,"amount":532,"abstract":533},"cordis-european-research-council-award-865817","PURism in Antiquity: Theories of Language in Greek Atticist Lexica and their Legacy","UNIVERSITA CA' FOSCARI  VENEZIA","€1,303,437","Linguistic purism, the attempt to protect language against the threat of multilingualism, change and outside contact, finds an antecedent in Greek Antiquity that remains mostly unknown outside Classics and has never been studied in a multidisciplinary perspective. PURA aims to overturn this state of affairs by producing the first global study of Greek purism, the texts which upheld it, and their legacy in later ages. The focus of this analysis are Atticist lexica: collections of features to be c",{"id":535,"funder":7,"programme":8,"title":536,"piName":10,"institution":537,"country":538,"year":13,"amount":539,"abstract":540},"cordis-european-research-council-award-101002966","Pathways to math difficulties -A longitudinal study from birth to school-age","JYVASKYLAN YLIOPISTO","FI","€1,999,608","EARLYMATH is an early-onset longitudinal research program with multiple longitudinal studies that cover birth to nine years of age in order to pursue an integrative understanding of early math development and pathways to math difficulties (MD). EARLYMATH investigates the roles of individual factors (i.e., neural, cognitive, affective and motivational), as well as environmental factors in the home and early childhood education and care (ECEC) and processes of intergenerational transmission of MD.",{"id":542,"funder":7,"programme":8,"title":543,"piName":10,"institution":544,"country":158,"year":13,"amount":545,"abstract":546},"cordis-european-research-council-award-101001448","Intranet of Neurons: A Minimally-invasive and High-capacity Transcranial Telemetry Network for Large-scale Brain-wide Neural Recordings","STICHTING IMEC NEDERLAND","€1,998,036","With the increase of people suffering from various neural disorders, the need for brain-computer interfaces (BCIs) to regain sensory-motor or cognitive functions are expected to become acute in the coming decades. However, the existing BCIs can only control simple motions, e.g., grasping, and are far from realizing our vision to help paralyzed patients to walk again. This is due to the lack of a high-bandwidth wireless BCI, capable of supporting the recording from a large number of neurons with ",{"id":548,"funder":7,"programme":8,"title":549,"piName":10,"institution":550,"country":60,"year":13,"amount":83,"abstract":551},"cordis-european-research-council-award-864253","Tissue-engineering the tumour microenvironment to improve treatment of pancreatic cancer","LEIBNIZ-INSTITUT FUR POLYMERFORSCHUNG DRESDEN EV","My vision is to address a clinical problem with a novel and transformative approach. Using my unique expertise in cell biology, tissue engineering and translational research I will design technology platforms to test new treatments for human pancreatic cancer.Pancreatic tumours are cancers of unmet medical need with 85% of patients dying within 9 months of diagnosis. To find better therapies, we need patient-specific models that mimic the biology of tumour tissues and target interactions between",{"id":553,"funder":7,"programme":8,"title":554,"piName":10,"institution":555,"country":169,"year":13,"amount":556,"abstract":557},"cordis-european-research-council-award-865564","Signs of Early Adaptation to Climate Change","FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA","€1,999,999","Nearly 8% of deaths are attributable to ambient temperatures, but little is known about the future impact in a warming world. I conducted studies in high-impact journals showing that this death toll can be largely reduced if a substantial degree of adaptation to ambient temperatures takes place. Adaptation strategies have been increasingly implemented in Europe in recent years, but the last IPCC report indicated that evidence of their effectiveness is still lacking. I postulate that adaptation m",{"id":559,"funder":7,"programme":8,"title":560,"piName":10,"institution":561,"country":158,"year":13,"amount":83,"abstract":562},"cordis-european-research-council-award-101002885","Learning from the past: linking ancestral epigenetic states to current cellular fates with single-cell multi-omic approaches","KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW","The establishment of cell type-specific transcriptional programs involves many interconnected regulatory mechanisms acting on different genomic scales. To dissect this multi-layered control of gene expression in detail, I will develop methods that a) measure multiple cellular outputs in single cells, and b) obtain that information in a time-resolved manner. This proposal outlines my approach to study early mouse development at numerous levels, including (but not limited to) transcription, chroma",{"id":564,"funder":7,"programme":8,"title":565,"piName":10,"institution":566,"country":567,"year":13,"amount":95,"abstract":568},"cordis-european-research-council-award-101001182","Synthesis of novel stimuli responsive dielectric polymers and their use in powerful transducers","EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT","CH","This ERC CoG will serve to build a strong multidisciplinary group concentrating on the synthesis of novel functional dielectric polymers that are printed into devices capable of converting one form of energy into another. Research spans all the way from materials’ synthesis and optimization, via device engineering to exploration of the manifold applications. TRANS will develop novel high dielectric permittivity elastomers and piezoelectric elastomers with an unprecedented collection of propertie",{"id":570,"funder":7,"programme":8,"title":571,"piName":10,"institution":572,"country":538,"year":13,"amount":573,"abstract":574},"cordis-european-research-council-award-101001016","Photoactivatable Drug Releasing Implants","HELSINGIN YLIOPISTO","€1,962,477","This proposal introduces a next-generation platform for next generation optimally personalised drug therapy: on-demand drug releasing implants triggered and controlled by blue\u002FUV light. The technology is based on novel light generation pathways and a light-sensitive nanocellulose drug reservoir.A formidable physiological barrier for light-triggered drug release has been the inability to use high-energy blue\u002FUV light as the triggering signal. This is because the penetration depth of light drops t",{"id":576,"funder":7,"programme":8,"title":577,"piName":10,"institution":498,"country":474,"year":13,"amount":578,"abstract":579},"cordis-european-research-council-award-101000850","Ancient Mesopotamian Priestly Scholasticism in the First Millennium BCE","€1,959,968","The scholarly texts of ancient Mesopotamia in the first millennium BCE, specifically commentaries written in Akkadian on cuneiform tablets, were the work of priests who also performed cultic activities in the temple. The proposed project seeks to demonstrate how these scholarly and cultic activities were interrelated and how they shaped the self-identity of the priestly-scholarly community that was in charge of both. The project thus aims to bridge the gap between the study of intellectual histo",{"id":581,"funder":7,"programme":8,"title":582,"piName":10,"institution":583,"country":474,"year":13,"amount":83,"abstract":584},"cordis-european-research-council-award-101001226","Deciphering the enigma of memory persistence: how the brain stably stores information using dynamic networks and unstable neurons","WEIZMANN INSTITUTE OF SCIENCE","How does the brain store and retrieve information over time? The accepted notion that these processes rely on the neuronal ensembles that were active during learning is now challenged by findings by our lab and others that reveal that different neurons and networks than those that were active during learning support persistent memory. Most notably, we found that the long-term persistence of spatial memory is correlated with the degree to which neuronal activity is spatially informative, but not ",{"id":586,"funder":7,"programme":8,"title":587,"piName":10,"institution":588,"country":134,"year":13,"amount":589,"abstract":590},"cordis-european-research-council-award-101001106","War and Fun: Reconceptualizing Warfare and Its Experience","CHR MICHELSENS INSTITUTT FOR VIDENSKAP OG ANDSFRIHET STIFTELSE","€1,999,340","The overall goal of WARFUN is to offer a new understanding of war and soldiering through a study of the role and implications of fun for soldiers and veterans. An understanding of the complexity of soldiers’ participation in war requires an epistemic change in conventional approaches. This project builds on a central hypothesis: fun is a key component of war. This, in turn, paves the way for three sub-hypotheses on the capacity of fun to reshape social categories and social practice, alter the l",{"id":592,"funder":7,"programme":8,"title":593,"piName":10,"institution":384,"country":60,"year":13,"amount":594,"abstract":595},"cordis-european-research-council-award-101001637","Sym-Bionic Matter: developing symbiotic relationships for light-matter interaction","€1,999,620","With the term symbiosis, biologists describe any type of close and long-term interaction between different organisms. Life diversity and ecosystems completely rely on such interactions therefore, especially in such rapid change environment, it is of utmost importance to understand their complexity and resilience.  Within this proposal, I aim to develop a new platforms to study these interactions in a spatially and chemically-controlled environment and manufacture a new class of hybrid materials:",{"id":597,"funder":7,"programme":8,"title":598,"piName":10,"institution":599,"country":203,"year":13,"amount":600,"abstract":601},"cordis-european-research-council-award-101002516","A multimodal approach to tendon mechanobiology","LUNDS UNIVERSITET","€2,002,622","Achilles tendon ruptures are common and costly, and more than 50% heal unsuccessfully. Tendons respond to mechanical load over time and loading is fundamental for good mechanical performance. However, the regulatory mechanisms are still largely unknown. The main objective of this proposal is to clarify how intact and ruptured healing Achilles tendons are responding to mechanical load. The hypothesis is that the underlying mechanisms can be elucidated through an advanced multimodal approach that ",{"id":603,"funder":7,"programme":8,"title":604,"piName":10,"institution":605,"country":40,"year":13,"amount":606,"abstract":607},"cordis-european-research-council-award-865819","AmplificatioN Free Identification of cancer and viral biomarkers via plasmonic nanoparticles and liquid BIOpsy","POLITECNICO DI TORINO","€2,725,510","The detection of circulating disease biomarkers in bodily fluids, also known as liquid biopsy, has taken important strides toward the implementation of personalized medicine. However, it still suffers from low sensitivity and high costs, which render its clinical implementation not practical or affordable. In particular, the identification and quantification of oligonucleotide biomarkers is hampered by the need to employ long- and short-read sequencing tools that are expensive, require highly tr",{"id":609,"funder":7,"programme":8,"title":610,"piName":10,"institution":611,"country":60,"year":13,"amount":612,"abstract":613},"cordis-european-research-council-award-101001619","Governance in Babylon: Negotiating the Rule of Three Empires","UNIVERSITAET MUENSTER","€1,999,740","GoviB is a historical study of governance in the ancient capital of Babylon. Babylonia is the earliest society in the ancient world that produced sufficient indigenous sources that allow studying the transition from a strongly anchored local to a more ‘global’ (imperial) form of governance. From the late 8th to the 4th century BC, Babylon experienced two major regime changes and was consecutively ruled by three empires – the Assyrian, the Chaldean and the (first) Persian. While the regime change",{"id":615,"funder":7,"programme":8,"title":616,"piName":10,"institution":617,"country":60,"year":13,"amount":618,"abstract":619},"cordis-european-research-council-award-866421","Timely Histories: A Social History of Time in South Asia","GEISTESWISSENSCHAFTLICHE ZENTREN BERLIN EV","€1,996,089","This project aims to write the history of time and temporal cultures in South Asia between the 1500s and the 1950s on a practice- and process-based history. Covering this broad timespan under five modular units, the objective is to investigate and write the graded pasts of shifts and transformations within them. In doing so, it departs from the usual approaches that focus either on the device (clock) or on the modern nation-state institutions such as army, school, factory, and office. Instead, w",{"id":621,"funder":7,"programme":8,"title":622,"piName":10,"institution":623,"country":94,"year":13,"amount":624,"abstract":625},"cordis-european-research-council-award-101001534","Extreme Soliton Driven Light Sources","HERIOT-WATT UNIVERSITY","€2,404,702","Many important breakthroughs in science have occurred when investigating the laws of nature at extremes. Strong-field effects, such as relativistic plasma dynamics, high-harmonic generation and laser-driven particle acceleration, appear at extreme intensities of electromagnetic fields. By using very short laser pulses and focusing them very tightly, these effects and their applications come within reach of table-top systems. I will explore extreme strong-field physics at the fundamental limits o",{"id":627,"funder":7,"programme":8,"title":628,"piName":10,"institution":629,"country":538,"year":13,"amount":630,"abstract":631},"cordis-european-research-council-award-101002728","Autoxidation of Anthropogenic Volatile Organic Compounds (AVOC) as a Source of Urban Air Pollution","TAMPEREEN KORKEAKOULUSAATIO SR","€2,689,147","Previous efforts to raise living standards have been based on relentlessly increasing combustion, causing environmental destruction at all scales. In addition to climate-warming CO2, fossil fuel combustion also produces a large number of organic compounds and particulate matter, which deteriorate air quality.The atmosphere is cleansed from such pollutants by gas-phase oxidation reactions, which are invariably mediated by peroxy radicals (RO2). Oxidation transforms initially volatile and water-in",{"id":633,"funder":7,"programme":8,"title":634,"piName":10,"institution":635,"country":245,"year":13,"amount":636,"abstract":637},"cordis-european-research-council-award-863818","Formal Methods for Stochastic Models: Algorithms and Applications","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","€1,997,918","The formal analysis of stochastic models plays an important role in different disciplines of science, e.g., probability theory, evolutionary stochastic processes in biology. In computer science, such models arise in formal verification of probabilistic systems, analysis of probabilistic programs, analysis of game-theoretic interactions with stochastic aspects, reasoning about randomized protocols, etc. At the heart of the analysis methods are algorithmic approaches that lead to automated tools. ",{"id":639,"funder":7,"programme":8,"title":640,"piName":10,"institution":641,"country":40,"year":13,"amount":642,"abstract":643},"cordis-european-research-council-award-101001857","A global economic organization in the early modern period: The Custody of the Holy Land through its account books (1600-1800)","UNIVERSITA DEGLI STUDI ROMA TRE","€1,964,456","The Franciscan Custody of the Holy Land (Custodia Terræ Sanctæ, established in the 13th century) is a global organization that, thanks to a complex system of alms gathering, has ensured throughout the centuries the maintenance of the Holy Sepulchre and the friars’ presence in the Holy Land. Despite its importance in Mediterranean History, the Custody has remained understudied, and its rich archive scarcely exploited. Inspired by recent studies on Franciscan economic thought and accounting in Med",{"id":645,"funder":7,"programme":8,"title":646,"piName":10,"institution":647,"country":40,"year":13,"amount":648,"abstract":649},"cordis-european-research-council-award-101003183","Modelling the Impact of Human Behaviours on Infections Spread","UNIVERSITA COMMERCIALE LUIGI BOCCONI","€1,986,437","Aim: The IMMUNE project will provide a ground-breaking interdisciplinary modelling framework that will explore the dynamics of human behavior on infections’ spread, through the lens of social sciences, integrating risk perceptions on diseases and vaccines, (mis)information campaigns, social peers influence and digitalisation. Background: Vaccines represent one of the most significant, cost-effective and safe public health interventions ever introduced. However, vaccine hesitancy has become alarm",{"id":651,"funder":7,"programme":8,"title":652,"piName":10,"institution":653,"country":474,"year":13,"amount":83,"abstract":654},"cordis-european-research-council-award-101001993","Navigating, Decision-Making and Sociality, Studying Behavior in the Wild from Birth to Adulthood","TEL AVIV UNIVERSITY","In the movie the Truman Show, Truman Burbank is astonished when discovering that he spent his entire life in a TV show. Monitoring a humans life is unethical, but many sociologists secretly dream about running such an experiment. Behavior-Island will allow to continuously monitor and manipulate a large population of bats from birth to adulthood. Behavior-Island will be established on Mauritius - the home of P. niger, which is a very interesting bat-model that: (a) lives for decades relying on lo",{"id":656,"funder":7,"programme":8,"title":657,"piName":10,"institution":486,"country":245,"year":13,"amount":658,"abstract":659},"cordis-european-research-council-award-101002357","Re-evaluating the Eleventh Century through Linked Events and Entities","€1,944,816","The aim of the RELEVEN project is to develop and test new ways for digital data about historical phenomena to be created and curated so that it is most useful to historians, and to apply these methods to a methodologically challenging yet very significant aspect of medieval history. The approach is to re-frame both existing and new historical data as assertions, often sourced but always linked to an authority",{"id":661,"funder":7,"programme":8,"title":662,"piName":10,"institution":663,"country":567,"year":13,"amount":664,"abstract":665},"cordis-european-research-council-award-865105","Mechanisms of dynamic localization of the bacterial Type 6 secretion system assembly","UNIVERSITAT BASEL","€2,493,650","The Type 6 secretion system (T6SS) allows Gram-negative bacteria to deliver toxins into both eukaryotic and bacterial target cells and thus cause disease or kill competitors. T6SS is composed of four main parts: a membrane complex, a baseplate and a long spring-like sheath wrapped around an inner tube. Sheath contraction generates a large amount of energy to push the tube with associated toxins through the baseplate and membrane complex out of the cell. However, the reach of the T6SS tube is lim",{"id":667,"funder":7,"programme":8,"title":668,"piName":10,"institution":669,"country":94,"year":13,"amount":670,"abstract":671},"cordis-european-research-council-award-101002086","Digital Scores – investigating the technological transformation of the music score","THE UNIVERSITY OF NOTTINGHAM","€1,999,985","Digital scores utilising computational technology and digital media are emerging worldwide as the next evolutionary stage in the concept of the music score (Vear 2019). Yet there has been no scientific study of digital scores; nor their effect upon creativity and musicianship. This is remarkable for two reasons:  First, because digital scores are generating new music experiences, innovative compositional approaches, novel performance opportunities, and broader accessibility for a vast number of ",{"id":673,"funder":7,"programme":8,"title":674,"piName":10,"institution":675,"country":60,"year":13,"amount":676,"abstract":677},"cordis-european-research-council-award-101001835","Simulation of Transport between the Adriatic Sea and the Danube","UNIVERSITAT TRIER","€1,923,805","Even though transport had a bad reputation in the discourse of the Roman elites, in recent research it became evident, that it had a vital impact on the prosperity of the Roman economy and thus on the long-term existence of the Roman Empire. Therefore, it is an absolute desideratum to explore Roman inland transport transdisciplinary, combining recent technological developments with experimental data and profound historical research to gain the most realistic transport times. The objective of STR",{"id":679,"funder":7,"programme":8,"title":680,"piName":10,"institution":669,"country":94,"year":13,"amount":681,"abstract":682},"cordis-european-research-council-award-101000969","Brain connectivity metrology for personalised neuroimaging in health and disease","€1,995,269","A key step towards untangling the complexity of the human brain is to understand how functionally specialised subunits are interconnected in the brain’s network to influence each other and produce experiences and behaviour. Magnetic resonance imaging uniquely allows to explore this systems-level view of neural connections and to probe brain organisation.Despite great promise, conventional approaches have experienced difficulties in delivering robust and tangible applications, particularly for th",{"id":684,"funder":7,"programme":8,"title":685,"piName":10,"institution":686,"country":567,"year":13,"amount":687,"abstract":688},"cordis-european-research-council-award-101001200","Tropical forest patches under pressure: Dynamics, functions and sustainable management in agricultural landscapes of the West African forest and savannah zones","UNIVERSITAET BERN","€1,998,512","Tropical forest patches in agricultural landscapes are largely the survivors of a hard-to-reverse deforestation process. Yet, these patches, which are spread over West Africa, still provide crucial ecological functions, serve as habitats for biodiversity, contribute globally to carbon sinks, and are important for the livelihoods of local populations. Given their persistent degradation, identifying pathways to safeguard or even increase their contribution to ecological function and thus to sustai",{"id":690,"funder":7,"programme":8,"title":691,"piName":10,"institution":692,"country":176,"year":13,"amount":10,"abstract":693},"cordis-european-research-council-award-865176","Blood-brain barrier: from molecular mechanisms to intervention strategies","UNIVERSITE LIBRE DE BRUXELLES","Brain endothelial cells (ECs) are endowed with a set of molecular and metabolic adaptations that stringently orchestrate the molecular and cellular transit between the brain and the circulatory system. These adaptations constitute the blood-brain barrier (BBB) and are pivotal to brain homeostasis and protection. Accordingly, BBB dysfunction is a unifying hallmark of many cerebrovascular diseases, including stroke, multiple sclerosis and neurodegeneration. Healing the BBB to treat to the brain is",{"id":695,"funder":7,"programme":8,"title":696,"piName":10,"institution":697,"country":94,"year":13,"amount":698,"abstract":699},"cordis-european-research-council-award-101001227","MMP and Mirrors via Maximal Modification Algebras","UNIVERSITY OF GLASGOW","€1,889,131","Geometrically, this proposal is concerned primarily with Calabi--Yau threefolds, their (local) classification, their homological properties, various associated structures such as stability conditions and Frobenius manifolds,  and the resulting predictions across mirror symmetry.  Our approach to these problems is through noncommutative algebra, and necessarily so.  We will use techniques from contraction algebras and noncommutative resolutions to classify, using both theoretical and constructive",{"id":701,"funder":7,"programme":8,"title":702,"piName":10,"institution":703,"country":203,"year":13,"amount":704,"abstract":705},"cordis-european-research-council-award-864287","Thresholds and tipping points in ecosystem responses to global warming","SVERIGES LANTBRUKSUNIVERSITET","€2,167,635","Terrestrial ecosystems are important in providing key services to humankind, but under global warming the provisioning of such ecosystem services is at risk. However, there is little consensus on how the functioning of terrestrial ecosystems will change under projected scenarios of global warming, or when we will reach or surpass thresholds and tipping points. This is largely because most studies have failed to unravel ecosystem responses to increasing temperatures in terms of the underlying non",{"id":707,"funder":7,"programme":8,"title":708,"piName":10,"institution":709,"country":710,"year":13,"amount":10,"abstract":711},"cordis-european-research-council-award-101002898","Economics of Inattention","EKONOMICKY USTAV AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE","CZ","This proposal outlines an agenda that aims to improve our understanding of economies with inattentive agents. Attention to detail, not only to current news, but also to how the world works in general, is central to how we interact with the environment. In the first part of the agenda, we will study how agents come up with the simplified mental models they use in their decision-making. The aim is to provide a new alternative to rational expectations. We will address the question of endogenous mod",{"id":713,"funder":7,"programme":8,"title":714,"piName":10,"institution":715,"country":169,"year":13,"amount":716,"abstract":717},"cordis-european-research-council-award-101002784","Transformative adaptation towards ocean equity","UNIVERSIDAD DE SANTIAGO DE COMPOSTELA","€1,999,478","Inequality is one of the key major social challenges of our time, with far-reaching ramifications for human well-being. Our oceans, which produce vital food, enable jobs and economic activities, and provide opportunities to shape cultures and identities of people, face unprecedented cumulative pressures from human activities and climate change due to industrialization of the seas. Although some researchers have explored ocean equity, significant gaps remain. Firstly, interdisciplinary approaches",{"id":719,"funder":7,"programme":8,"title":720,"piName":10,"institution":175,"country":176,"year":13,"amount":721,"abstract":722},"cordis-european-research-council-award-101001024","Electro- and photochemical microreactors intensified by acoustics","€1,994,500","Small-scale flow reactors for electro- and photochemistry support the shift in chemical manufacture towards green and sustainable processes based on renewable energy sources. However, the industrial application of these small-scale flow reactors is significantly limited by their currently achieved throughput and productivity.The MICRODISCO project aims to overcome these productivity limitations by exploiting the synergistic effect of ultrasound on intensified electro- and photochemical reactors.",{"id":724,"funder":7,"programme":8,"title":725,"piName":10,"institution":726,"country":203,"year":13,"amount":83,"abstract":727},"cordis-european-research-council-award-101002772","Spin Engineering in Flexible and Functional Two-Dimensional Quantum Material Devices","UPPSALA UNIVERSITET","Can spin integrated circuits (Spin-ICs) with low power-high speed processing capabilities be realized? What are the key ingredients necessary to catapult present-day spintronics to make such a leap? The emergence of two-dimensional (2D) quantum crystals provides new impetus for exploring ambitious ultralow-power and ultrafast speed prospects of spintronics and nanomagnetism. Atomically thin 2D quantum materials like graphene have created novel possibilities for pure spin current communication, f",{"id":729,"funder":7,"programme":8,"title":730,"piName":10,"institution":731,"country":60,"year":13,"amount":732,"abstract":733},"cordis-european-research-council-award-101001065","Magma Outgassing During Eruptions and Geothermal Exploration","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€2,821,036","Magmatism is central to planetary evolution, controlling differentiation, volcanic eruptions and most geothermal systems. The presence of volatiles regulates magma buoyancy, storage and transport. As temperature, pressure and stress evolve – during transport, crystallisation, earthquakes or geothermal exploration – volatiles exsolve and either accumulate or escape magma, influencing the probability and style of an eruption. Understanding the controls on magma-gas coupling is thus fundamental to ",{"id":735,"funder":7,"programme":8,"title":736,"piName":10,"institution":737,"country":158,"year":13,"amount":738,"abstract":739},"cordis-european-research-council-award-101001237","Improving Prognosis by using innovative methods to diAgnose Causes of Encephalitis","STICHTING AMSTERDAM UMC","€1,968,996","Background: Encephalitis is a severe inflammation of the brain that can be caused by viruses, bacteria and other microorganisms, or autoimmune disease. The impact is high: the case fatality rate is 10-20% and half of patients have neurological deficits. Identifying the cause of encephalitis is essential for early initiation of therapy and thereby improves outcome.The clinical challenge: Current diagnostics for encephalitis are insufficient. My prospective pilot study showed that the cause of enc",{"id":741,"funder":7,"programme":8,"title":742,"piName":10,"institution":743,"country":40,"year":13,"amount":744,"abstract":745},"cordis-european-research-council-award-101002763","The Roman Emperor Seen From the Provinces. Imaging Roman Power in the Cities of the Empire from Augustus to the Tetrarchs (31 BC-AD 297)","UNIVERSITA DEGLI STUDI DI VERONA","€1,998,026","This project will investigate the processes by which the representations of Roman emperors were created and disseminated from a new ‘peripheral’ perspective, which emphasizes the cultural, religious and artistic background of the local communities in the imperial provinces rather than the traditional ‘central’ one in Rome. It will study the ways in which Roman emperors were portrayed, celebrated and worshipped in the provincial cities, in the western and especially the eastern regions of the Med",{"id":747,"funder":7,"programme":8,"title":748,"piName":10,"institution":749,"country":60,"year":13,"amount":750,"abstract":751},"cordis-european-research-council-award-101001794","Photoresponsive Multi-Addressable Smart Materials and Mechanical Synthesis by Molecular Machines","FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG","€1,996,631","In this proposal a research program is envisioned to make a true leap in the creation of light-responsive intelligent matter. It targets the current frontiers and limits of photoswitching, molecular machines, chemical synthesis, and precision engineering of multi-responsive materials and will have profound impacts in - and beyond these fields. It encompasses the creation of novel visible-light responsive photoswitches with general applicability across the natural sciences and the elucidation of ",{"id":753,"funder":7,"programme":8,"title":754,"piName":10,"institution":244,"country":245,"year":13,"amount":83,"abstract":755},"cordis-european-research-council-award-101002685","Automated Reasoning with Theories and Induction for Software Technology","The long list of software failures over the past years calls for serious concerns in our digital society, creating bad reputation and adding huge economic burden on organizations, industries and governments. Improving software reliability is no more enough, ensuring software reliability is mandatory. Our project complements other advances in the area and addresses this demand by turning first-order theorem proving into an alternative, yet powerful approach to ensuring software reliability, Satur",{"id":757,"funder":7,"programme":8,"title":758,"piName":10,"institution":759,"country":176,"year":13,"amount":760,"abstract":761},"cordis-european-research-council-award-101002571","REpurposing lung Surfactant Protein B for Inhalation therapy with RNA therapeutics","UNIVERSITEIT GENT","€1,985,828","RESPIRNA aims to repurpose lung surfactant protein B (SP-B) to promote the cytosolic delivery of RNA in lung-related target cells. RNA therapeutics, including small interfering RNA (siRNA) and messenger RNA (mRNA), are poised to revolutionize medicine. However, despite a clear unmet medical need in many lung diseases, no RNA formulations are currently available for pulmonary administration. To unlock the full therapeutic potential of RNA drugs, safe and efficient nanomedicines that can deliver t",{"id":763,"funder":7,"programme":8,"title":764,"piName":10,"institution":765,"country":60,"year":13,"amount":83,"abstract":766},"cordis-european-research-council-award-101002090","High-Precision Global Analysis of Color-Free LHC Processes at Small Recoil","DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY","The Large Hadron Collider (LHC) at CERN collides protons at the highest energies. With the large datasets from Run 2 and the further increase expected from Run 3, the precision of LHC measurements will significantly improve over the next years. Color-free processes (for which the final state of the hard interaction is color neutral) are of central importance to several high-priority areas of the LHC precision physics program. Prominent examples are measurements of the W-boson mass, of the coupli",{"id":768,"funder":7,"programme":8,"title":769,"piName":10,"institution":770,"country":567,"year":13,"amount":771,"abstract":772},"cordis-european-research-council-award-864792","The redox evolution of arc magmas: from the oxygenation of the Earth’s atmosphere to the genesis of giant hydrothermal ore deposits","UNIVERSITE DE GENEVE","€2,406,972","Arc magmatism at subduction zones is responsible for much of the mass transfer of chemical elements between the Earth’s lower and upper spheres. Arc magmas are significantly more oxidized and richer in volatile elements than other voluminous magma types on Earth. These characteristics promote the genesis of large magmatic-hydrothermal ore deposits and potentially also the build-up of the oxygen budget of the Earth’s atmosphere. Despite its great significance, the origin of the higher oxidation s",{"id":774,"funder":7,"programme":8,"title":775,"piName":10,"institution":776,"country":710,"year":13,"amount":777,"abstract":778},"cordis-european-research-council-award-101000442","Networks of Dissent: Computational Modelling of Dissident and Inquisitorial Cultures in Medieval Europe","Masarykova univerzita","€1,991,868","The DISSINET project will provide an unprecedented, “networked” understanding of dissident religious and inquisitorial cultures in medieval Europe through a vast computational analysis of the social, spatial, and textual relationships by which they were formed and recorded. Rather than treating these cultures through narrative case-study or traditional social-historical analysis, our approach will build upwards from the microscopic details of human interactivity towards a broader social picture.",{"id":780,"funder":7,"programme":8,"title":781,"piName":10,"institution":782,"country":60,"year":13,"amount":783,"abstract":784},"cordis-european-research-council-award-101001638","Metabolic Mechanical Materials: Adaptation, Learning & Interactivity","JOHANNES GUTENBERG-UNIVERSITAT MAINZ","€1,998,750","The central objective of M3ALI is to introduce concepts for adaptation, simplistic learning by training (physical exercise, not teaching), and interactivity in mechanically stimulated polymer materials by developing metabolic modules for mechanical memories (that can also be forgotten), for down-stream chemical processes and for active communication.  The key experimental methodology is based on two classes of molecularly engineered mechanoprobes (MPs) that are capable of defined downstream reac",{"id":786,"funder":7,"programme":8,"title":787,"piName":10,"institution":788,"country":169,"year":13,"amount":789,"abstract":790},"cordis-european-research-council-award-101003295","Unconventional Superfluids in  Quantum Gases with Competing Interactions","FUNDACIO INSTITUT DE CIENCIES FOTONIQUES","€1,997,381","Unconventional superfluids, where frictionless flow appears combined with features such as topological excitations or crystalline order, are some of the most surprising collective quantum phases of matter. Although the corresponding topological superfluids and supersolids were originally predicted in condensed matter, ultracold quantum gases provide a more controlled experimental approach to these phases, and promise microscopic access to their exotic properties. A key mechanism towards unconven",{"id":792,"funder":7,"programme":8,"title":793,"piName":10,"institution":794,"country":567,"year":13,"amount":795,"abstract":796},"cordis-european-research-council-award-101003216","Trade Law for the Data-Driven Economy","UNIVERSITAT LUZERN","€1,600,975","Data has been conceptualized as the ‘new oil’ and although this is a flawed statement, it catches well the value attached to data as a driver of economic growth and innovation, and as a force of change in all facets of societal life. Accordingly, data has emerged as an important topic in contemporary law and policy—on the one hand, because it is critical to understand whether and how different societal areas have been affected by digital transformations, including disruptive phenomena like Big D",{"id":798,"funder":7,"programme":8,"title":799,"piName":10,"institution":800,"country":245,"year":13,"amount":801,"abstract":802},"cordis-european-research-council-award-101001691","Developing a novel framework for understanding  and scaling near-surface turbulence in complex terrain","UNIVERSITAET INNSBRUCK","€1,960,392","Atmospheric turbulence exerts a dominant control on the exchange of heat, CO2, water vapor, pollutants and momentum between the surface and the atmosphere, and therefore drives phenomena as diverse as climate, storm systems, air pollution, and glacial melt. Existing turbulence theory was developed for horizontally homogenous flat terrain, and fails in more complex terrain. Thus, for the majority of our planetary surface no viable theory of turbulence is available, and approaches that are known t",{"id":804,"funder":7,"programme":8,"title":805,"piName":10,"institution":806,"country":60,"year":13,"amount":807,"abstract":808},"cordis-european-research-council-award-101002812","Mechanoradicals in Collagen","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","€1,998,873","Our tissues, in particular collagen as the most abundant protein in our body, are constantly exposed to mechanical loads, reaching multiples of the body weight. In artificial polymers, mechanical loads are known for a century to cause radical formation and chemical degradation processes. Mechanoradicals from bond ruptures, being highly reactive and oxidising, deteriorate the material, leading to stiffening and ageing. Ageing of organic tissue is a fundamental problem in health and disease, but a",{"id":810,"funder":7,"programme":8,"title":811,"piName":10,"institution":812,"country":94,"year":13,"amount":813,"abstract":814},"cordis-european-research-council-award-101001331","Beyond Massive MIMO: Living at the Interface of Electromagnetics and Information Theory","THE QUEEN'S UNIVERSITY OF BELFAST","€1,997,797","Massive multiple-input multiple-output (MaMi) is now a core technology for 5G networks. With MaMi, we refer to systems with an unconventionally large number (e.g. hundreds or even thousands) of base station antennas simultaneously serving tens (or even hundreds) of users. To date, the development of MaMi has been exclusively based on information theory (IT) tailored towards cellular communications. While IT is undoubtedly a versatile mathematical tool, it is based on mathematical logic. This the",{"id":816,"funder":7,"programme":8,"title":817,"piName":10,"institution":561,"country":158,"year":13,"amount":83,"abstract":818},"cordis-european-research-council-award-101003210","Understanding DNA interstrand crosslink repair  – the Fanconi anemia pathway and beyond","DNA interstrand crosslinks (ICLs) are toxic DNA lesions that are induced by cancer chemotherapeutics but are also formed endogenously. ICL repair is mostly linked to DNA replication, which complicated the biochemical dissection of this process. The classical ICL repair pathway is the Fanconi anemia pathway, affected in the cancer predisposition syndrome Fanconi anemia (FA). Although the repair mechanism is poorly understood, recent studies have revealed unanticipated insights that now allow us t",{"id":820,"funder":7,"programme":8,"title":821,"piName":10,"institution":822,"country":158,"year":13,"amount":823,"abstract":824},"cordis-european-research-council-award-101000987","Fire in the land of ice: Climatic drivers and feedbacks","STICHTING VU","€2,371,691","2019 was the largest fire year since at least 1997 within the Arctic Circle, largely driven by Siberian fires. The arctic-boreal region stores about two atmospheres worth of soil carbon with 90 % currently locked in permafrost soils, or perennially frozen ground. Fire releases parts of this carbon stock, which may induce a vigorous climate warming feedback.FireIce will investigate feedbacks between climate warming and arctic-boreal fires by studying direct and longer-term carbon emissions from f",{"id":826,"funder":7,"programme":8,"title":827,"piName":10,"institution":106,"country":53,"year":13,"amount":828,"abstract":829},"cordis-european-research-council-award-866158","Tunable Hubbard Lattices in Semiconductor Nanowire Networks","€1,999,669","One of the most important outstanding questions in physics is arguably the understanding of correlated electrons in condensed matter. The theoretical framework is given by the Hubbard model, however, no analytical solutions have been found and numerical treatments are challenging and controversial. Although great progress has been made in experimental implementations of the Hubbard model in cold atom lattices and ion traps, the most interesting regime of low temperature and strong interactions, ",{"id":831,"funder":7,"programme":8,"title":832,"piName":10,"institution":833,"country":834,"year":13,"amount":835,"abstract":836},"cordis-european-research-council-award-101002993","Transnational Advocacy and Corporate Accountability for Major International Crimes","SCOALA NATIONALA DE STUDII POLITICE SI ADMINISTRATIVE","RO","€1,661,015","This project provides crucial insights into the transnational mobilisations and counter-mobilisations for holding multinational corporations and their representatives accountable for complicity in major international crimes (genocide, war crimes, crimes against humanity) committed during dictatorships and violent conflicts since the 1970s. It brings three major innovations to an emergent literature in the fields of transitional justice and international criminal law that recently turned its atte",{"id":838,"funder":7,"programme":8,"title":839,"piName":10,"institution":840,"country":245,"year":13,"amount":841,"abstract":842},"cordis-european-research-council-award-101001971","Understanding and exploiting epigenetic regulation in CAR T cell therapy","CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH","€1,999,913","The dramatic efficacy of CAR T cell therapy in certain hematopoietic malignancies provides clinical validation of a groundbreaking paradigm: Human cells can be engineered into purpose-built therapeutic agents by genetically introducing artificial regulatory programs. The EPI-CART project will focus on epigenetic regulation in CAR T cell therapy – an important but underappreciated aspect of all cell-based therapies.We will investigate the regulatory dynamics during CAR T cell therapy in unprecede",{"id":844,"funder":7,"programme":8,"title":845,"piName":10,"institution":846,"country":94,"year":13,"amount":83,"abstract":847},"cordis-european-research-council-award-101001169","Protein Structure, Molecular Mechanisms and Human Genetic Disease: Beyond the Loss-of-function Paradigm","THE UNIVERSITY OF EDINBURGH","The ability to identify damaging genetic variants is central to the diagnosis, treatment and prevention of human disease. Computational phenotype predictors are widely used for prioritising likely pathogenic mutations, but their utility is limited by their accuracy. Conversely, experimental characterisation of variants is powerful but time consuming and difficult to perform on a large scale, limiting applicability in routine variant prioritisation. In this project, we will improve our ability to",{"id":849,"funder":7,"programme":8,"title":850,"piName":10,"institution":851,"country":245,"year":13,"amount":852,"abstract":853},"cordis-european-research-council-award-101001407","Artistic Research in Museums and Communities in the process of Repatriation from Europe","CEU GMBH","€1,993,066","What innovations to the repatriation of cultural property can be performed by making new originals? The specific objectives of REPATRIATES are to bring together internationally art-based research actions that respond to repatriation, to learn from exchanges between French, German, Austrian and British institutions and stakeholder indigenous communities. REPATRIATES examines how contested objects - whose ownership may remain unclear - can be concieved and exhibited sensitively. It develops strate",{"id":855,"funder":7,"programme":8,"title":856,"piName":10,"institution":93,"country":94,"year":13,"amount":857,"abstract":858},"cordis-european-research-council-award-101002277","Foundations of Type Inference for Modern Programming Languages","€1,999,998","Many modern programming languages, whether developed in industry, like Rust or Java, or in academia, like Haskell or Scala, are typed. All the data in a program is classified by its type (e.g., as strings or integers), and at compile-time programs are checked for consistent usage of types, in a process called type checking. Thus, the expression 3 + 4 will be accepted, since the + operator takes two numbers as arguments, but the expression 3 + hello will be rejected, as it makes no sense to add a",{"id":860,"funder":7,"programme":8,"title":861,"piName":10,"institution":862,"country":60,"year":13,"amount":863,"abstract":864},"cordis-european-research-council-award-101000991","Beyond Property: Law and Land in the Iberian World (1510-1850)","GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER","€1,983,193","The experience of empire decisively shaped the institution of private property in land. From a global perspective, however, the history of this institution is far from straightforward. While European scholarship places the advent of individual property rights in the late 18th century, scholarship on Asia, Africa, and the Americas often attributes the onset of the paradigm of private property to the arrival of Europeans in the 16th century. This discrepancy of almost 300 years is difficult to rec",{"id":866,"funder":7,"programme":8,"title":867,"piName":10,"institution":868,"country":538,"year":13,"amount":869,"abstract":870},"cordis-european-research-council-award-101002219","Cross-dimensional Activation of Two-Dimensional Semiconductors for Photocatalytic Heterojunctions","OULUN YLIOPISTO","€1,999,946","Spacetime defines existence and evolution of materials. A key path to human’s sustainability through materials innovation can hardly circumvent materials dimensionalities. Despite numerous studies in electrically distinct 2D semiconductors, the route to engage them in high-performance photocatalysts remains elusive. Herein, CATCH proposes a cross-dimensional activation strategy of 2D semiconductors to implement practical photocatalysis. It operates electronic structures of dimensionally paradoxi",{"id":872,"funder":7,"programme":8,"title":873,"piName":10,"institution":874,"country":875,"year":13,"amount":298,"abstract":876},"cordis-european-research-council-award-101000893","Saturated bioisosteres of benzene  and their application in drug design","ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE","UA","More than 500 of all existing drugs are phenyl-containing organic molecules. During the recent years, however, pharmaceutical companies struggle to deliver novel drugs to the market, because of the lack of innovative practical approaches towards novel drug-like “chemical space.” In this project, we will address this issue by developing novel saturated bioisosteres for ortho- and meta-substituted benzenes, and incorporate them into several known drugs (intiinflamatory Aceclofenac, antiviral Tipra",{"id":878,"funder":7,"programme":8,"title":879,"piName":10,"institution":880,"country":158,"year":13,"amount":83,"abstract":881},"cordis-european-research-council-award-101002123","EcoWizard: innovative nanomaterials require ecologically based safety assessment","UNIVERSITEIT LEIDEN","Engineered nanomaterials (ENMs) are widely used, and nanotechnological innovations grow with rapid pace. Studies on nanotoxicology have demonstrated that chemical toxicology as well as particle toxicology should be accounted for in predicting the safety of ENMs; and no simple correlation between toxic responses and mass, nanoparticle size or any other particle characteristic is found. Effects often occur only after long-term exposure, whereas evidence of acute toxicity induced by ENMs is limited",{"id":883,"funder":7,"programme":8,"title":884,"piName":10,"institution":846,"country":94,"year":13,"amount":885,"abstract":886},"cordis-european-research-council-award-101002385","RNA functions in parasite-host communication in the gut","€1,993,771","Cross-species communication is required for proper functioning of the mammalian gut, where different organisms share resources, coordinate digestion and maintain homeostasis. In many animals, parasitic worms (helminths) are part of this ecosystem, where they communicate through the release of bio-active molecules that promote immunological tolerance and modulate gut functions. Mechanisms of cross-species communication are still not well understood and my lab discovered that ribonucleic acids (RN",{"id":888,"funder":7,"programme":8,"title":889,"piName":10,"institution":890,"country":12,"year":13,"amount":83,"abstract":891},"cordis-european-research-council-award-101003012","Not Getting Lost in Multi-Scale Maps: Exploring the Anchor Theory in Cartographic Zoom Interactions in the Context of Crisis Management","INSTITUT NATIONAL DE L'INFORMATION GEOGRAPHIQUE ET FORESTIERE","Multi-scale interactive maps such as Google Maps or OpenStreetMap have replaced paper topographic maps for most professional and daily uses. Past research told us how to design paper topographic maps at a given scale to make them readable and understandable by human users. But these rules\u002Fguidelines do not apply anymore, and map designers lack guidelines to make maps that are smooth to explore through scales, and it is common for a multi-scale map user to feel lost for a few seconds after a zoom",{"id":893,"funder":7,"programme":8,"title":894,"piName":10,"institution":895,"country":538,"year":13,"amount":83,"abstract":896},"cordis-european-research-council-award-101001417","Quantitative Tomography Using  Coupled Physics of Waves","ITA-SUOMEN YLIOPISTO","Tomographic images are a valuable tool in various applications of medicine and biomedicine, industry and in security applications. Although efficient tomographic imaging techniques exist, development of new modalities that would overcome the limitations of the existing techniques are required. Overall, there is a need for development of new tomographic techniques that would provide quantitative information of unknown parameters of interest, such as tomographic images on the concentration of mole",{"id":898,"funder":7,"programme":8,"title":899,"piName":10,"institution":93,"country":94,"year":13,"amount":900,"abstract":901},"cordis-european-research-council-award-101002652","Next-Generation Data-Driven Probabilistic Modelling of Type Ia Supernova SEDs in the Optical to Near-Infrared for Robust Cosmological Inference","€2,446,736","Type Ia supernovae (SNe Ia) are used as “standardiseable candles”: their peak luminosities can be inferred from their optical light curve shapes and colours, so their distances can be estimated from their apparent brightnesses. SN Ia distances with high precision and small systematic error are essential to accurate constraints on the cosmic expansion history, local measurements of the Hubble constant, and the properties of the dark energy driving the acceleration, in particular, its equation-of-",{"id":903,"funder":7,"programme":8,"title":904,"piName":10,"institution":731,"country":60,"year":13,"amount":905,"abstract":906},"cordis-european-research-council-award-101002243","The Transformation of Jewish Literature in Arabic in the Islamicate World","€1,994,000","In pre-modern times, an estimated ninety percent of the Jewish population lived under Muslim hegemony. Over the centuries, these Jews not only adopted the Arabic language for most forms of spoken and written communication, but also integrated concepts and techniques from their intellectual environment, resulting in one of the most extraordinary periods of literary creativity in all of Jewish history. Despite its importance, however, Judaeo-Arabic literature has been under-researched until very r",{"id":908,"funder":7,"programme":8,"title":909,"piName":10,"institution":776,"country":710,"year":13,"amount":910,"abstract":911},"cordis-european-research-council-award-101002660","Informal Judicial Institutions: Invisible Determinants of Democratic Decay","€1,999,750","Mainstream literature on courts focuses on formal rules. Yet informal judicial institutions, ranging from bureaucratic norms to clientelism, often shape judicial performance strongly. These institutions may even facilitate democratic decay. For example, various “gentlemen’s pacts” between judicial associations may substitute formal rules governing selection of judges, entrenching patronage and vertical gender segregation. Politically savvy chief justice can tweak the formal rules and forge allia",{"id":913,"funder":7,"programme":8,"title":914,"piName":10,"institution":915,"country":203,"year":13,"amount":83,"abstract":916},"cordis-european-research-council-award-101001374","Release of engineered extracellular vesicles for delivery of biotherapeutics","KAROLINSKA INSTITUTET","Nucleic acid-based medicines have opened a new avenue in drug discovery to target currently undruggable genes and to express therapeutic proteins, unlocking novel therapeutic options for a range of diseases, including neurodegeneration. However, they need to be encapsulated in nanocarriers to ensure their stability and efficient uptake into cells and tissues. Synthetic nanoparticles based on cell-penetrating peptides (CPPs) and, particularly, lipid nanoparticles (LNPs) have recently emerged as p",{"id":918,"funder":7,"programme":8,"title":919,"piName":10,"institution":920,"country":94,"year":13,"amount":921,"abstract":922},"cordis-european-research-council-award-101003096","GAIA-BInaries: Formation and fundamental pRoperties Of Stars and planeTary systems","THE UNIVERSITY OF EXETER","€2,998,750","Systems with close stellar-mass or planetary-mass companions are ubiquities in the universe. However, the processes that shape the architecture of these systems are still not understood. By 2021 the GAIA mission will provide astrometric+radial velocity orbits for millions of multiple systems. For the vast majority, GAIA will measure only photocenter displacements and not be able to resolve the individual components, preventing masses and orbital statistics to be derived.  The aim of the GAIA-BIF",{"id":924,"funder":7,"programme":8,"title":925,"piName":10,"institution":697,"country":94,"year":13,"amount":926,"abstract":927},"cordis-european-research-council-award-101001634","Towards the discovery of cellular RNA-binding proteins with master regulatory roles in virus infection","€1,999,916","RNA is a central molecule for RNA virRNA is a central molecule for RNA virus infection. However, viral genomes encode very few proteins that are able to interact with viral RNA. Hence, viruses co-opt cellular RNA-binding proteins (RBPs) to support infection. The host cell also employs RBPs to combat viruses through the recognition of unusual signatures present viral RNAs. Despite these critical roles, the complement of cellular RBPs involved in infection remains largely unknown. This research pr",{"id":929,"funder":7,"programme":8,"title":930,"piName":10,"institution":451,"country":53,"year":13,"amount":83,"abstract":931},"cordis-european-research-council-award-101002725","Bioactive peptides from human brown fat cells mediating metabolic control","Obesity is an increasing problem where the central nervous system (CNS) plays a major role by regulating food intake. This regulation is based on feedback systems from peripheral organs, including adipose tissue. Brown adipose tissue (BAT) is a subtype of adipose tissue that produces heat in response to cold by switching from an idle state to a highly energy-consuming state. BAT also secretes signalling molecules called batokines, but the biological effects of batokines on distal tissues are unc",{"id":933,"funder":7,"programme":8,"title":934,"piName":10,"institution":935,"country":936,"year":13,"amount":937,"abstract":938},"cordis-european-research-council-award-101002854","Pragmatics of Multiwinner Voting: Algorithms and Preference Data Analysis","AKADEMIA GORNICZO-HUTNICZA IM. STANISLAWA STASZICA W KRAKOWIE","PL","€1,386,290","This proposal is in the area of computational social choice, an area on the intersection of computer science and economics. We study multiwinner elections, with a focus on a pragmatic approach. Our goal is to provide a principled framework for applying multiwinner voting in various settings that may appear in real-life (ranging from small-scale elections in various institutions, through participatory budgeting settings, to applications directly within computer science). In particular, we are int",{"id":940,"funder":7,"programme":8,"title":941,"piName":10,"institution":942,"country":94,"year":13,"amount":943,"abstract":944},"cordis-european-research-council-award-101001601","Upward mantle flow from novel seismic observations","UNIVERSITY COLLEGE LONDON","€2,843,038","While downward mantle flow (subduction) is well constrained, a grand challenge in Earth sciences is to understand deep upward flow that cannot be explained by plate tectonics. The aim of UPFLOW is to develop an entirely new seismic imaging approach and to use it to constrain plume-like mantle upwellings at unprecendented resolution. Upward flow is critical for continental growth, for returning volatiles to the atmosphere and for producing Earth's largest melting events. These events coincide wit",{"id":946,"funder":7,"programme":8,"title":947,"piName":10,"institution":492,"country":169,"year":13,"amount":83,"abstract":948},"cordis-european-research-council-award-101002927","Uncovering Protein Mechanics in Physiology and Disease","Protein mechanics is a key contributor to the form and function of biological systems by mechanisms that are just starting to be unraveled. An ensuing hypothesis is that alteration of protein mechanics can trigger disease, particularly in mechanical conditions such as cardiomyopathies in which primordial underlying molecular mechanisms remain elusive. Although tempting, this possibility has not been tested due to the absence of methods that can modulate the mechanics of proteins in vivo. My prop",{"id":950,"funder":7,"programme":8,"title":951,"piName":10,"institution":952,"country":158,"year":13,"amount":953,"abstract":954},"cordis-european-research-council-award-101001678","Modulating the gut microbiome to enhance drug efficacy","ACADEMISCH ZIEKENHUIS GRONINGEN","€1,999,676","Individual response rates to drugs that are widely prescribed to treat common diseases are typically in the range of 50-75%, yet the slow progress and high costs associated with new drug development do not meet the urgent need for new treatment options, particularly given the rapidly increasing burden of chronic diseases.  This ERC project tackles this pressing issue by defining the impacts of the gut microbiome and genetics on drug metabolism, ultimately enabling personalized approaches that en",{"id":956,"funder":7,"programme":8,"title":957,"piName":10,"institution":958,"country":567,"year":13,"amount":83,"abstract":959},"cordis-european-research-council-award-101001295","Engineering Interdependence - A Window into the Evolution of the Human Mind","UNIVERSITAT ZURICH","The human mind is very similar to that of other great apes, yet also strikingly different, and a vast body of research converges on one conclusion: this gap is fundamentally social. Moreover, it emerges early in ontogeny, reflects the distinctly human neurochemical profile, and is characterized by physiological, hormonal, and behavioural synchronicity. But why did this gap evolve in the first place, and why was it us, rather than any of the other great apes, who diverged so dramatically and evol",{"id":961,"funder":7,"programme":8,"title":962,"piName":10,"institution":963,"country":40,"year":13,"amount":385,"abstract":964},"cordis-european-research-council-award-101002811","Genomes, food and microorganisms in the (pre)history of cat-human interactions","UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA","Pest-control agent, object and symbol of value in past civilisations, companion animal, and iconic celebrity of the web in the modern society, the domestic cat has an intricate bond with humans. This relationship started more than 10,000 years ago, when cats began scavenging and hunting pests that infested granaries of early farming communities in the Near East. Later in history, cats from Egypt dispersed in the Mediterranean following routes of human trade and connectivity. Cats established a u",{"id":966,"funder":7,"programme":8,"title":967,"piName":10,"institution":968,"country":82,"year":13,"amount":969,"abstract":970},"cordis-european-research-council-award-866126","Advanced Cellular Hierarchical Tissue-Imitations based on Excluded Volume Effect","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","€2,076,770","ACHIEVE focuses on the application of Excluded Volume Effect in cell culture systems in order to enhance Extracellular Matrix (ECM) deposition.  It represents a new horizon in in vitro cell culture which will address major challenges in medical advancement and food security. ACHIEVE will elucidate extracellular processes which occur during tissue generation, identifying favourable conditions for optimum tissue cultivation in vitro. These results will be applied in the diverse fields of regenerat",{"id":972,"funder":7,"programme":8,"title":973,"piName":10,"institution":498,"country":474,"year":13,"amount":974,"abstract":975},"cordis-european-research-council-award-101001731","Textual Microcosms: A New Approach in Translation Studies","€1,999,655","Interlinear translation – a bilingual genre that includes an original text and its word-for-word ‘equivalents’ in translation written in alternating lines on a single page – has been practiced in diverse societies over many centuries, yet has been little studied. Because it prioritizes detail and precision, the interlinear translation paradigm tells us more than any other about the workings of translation and the unavoidable choices inherent in every translation act. This project employs the int",{"id":977,"funder":7,"programme":8,"title":978,"piName":10,"institution":979,"country":60,"year":13,"amount":980,"abstract":981},"cordis-european-research-council-award-101001791","AI-augmented, Multiscale Image-based Diagnostics  of Chronic Kidney Disease","UNIVERSITAETSKLINIKUM AACHEN","€1,999,375","Chronic kidney disease (CKD) is a major global health problem, affecting 10% of the world population and projected to be the fifth major cause of death in 2040. CKD patients are one of the most complex and multi-morbid populations in internal medicine while at the same time having the least translational randomized clinical trials and limited treatment options. One of the major reasons for this is the lack of reproducible approaches specifically reflecting intrarenal pathological processes and d",{"id":983,"funder":7,"programme":8,"title":984,"piName":10,"institution":93,"country":94,"year":13,"amount":985,"abstract":986},"cordis-european-research-council-award-101001221","Micro Structure and Macro Outcomes","€1,877,295","MICRO2MACRO proposes a research agenda where macroeconomic outcomes emerge as the equilibrium aggregation of decisions by interlinked micro-units of production operating in narrow, possibly frictional, markets and subject to localized shocks.  Under this broad agenda, the project focuses on three different themes. The first theme of MICRO2MACRO develops novel theory on market power in production networks and explores how this perspective may inform policy makers and academics. It asks the follow",{"id":988,"funder":7,"programme":8,"title":989,"piName":10,"institution":106,"country":53,"year":13,"amount":83,"abstract":990},"cordis-european-research-council-award-101001078","Discovering New Dual and Triple Atom Catalysts","The central goal of DETECT is to discover and establish new fundamental insight into the catalytic activity of duel and triple atom catalysts. Many chemical reactions – several related to securing a wider penetration of renewable energy – are not viable today due to a number of limitations of traditional catalysts including unfavorable scaling relations of intermediates, lack of selectivity, and cost and availability of precious metals. Employing catalysts consisting of only two or three atoms o",{"id":992,"funder":7,"programme":8,"title":993,"piName":10,"institution":994,"country":60,"year":13,"amount":995,"abstract":996},"cordis-european-research-council-award-865170","Property-Based Modulable Timing Analysis and Optimization for Complex Cyber-Physical Real-Time Systems","TECHNISCHE UNIVERSITAT DORTMUND","€1,999,055","Cyber-physical real-time systems are information processing systems that require both functional as well as timing correctness and have interactions with the physical world. Since time naturally progresses in the physical world, safe bounds of deterministic or probabilistic timing properties are required.  PropRT will explore the possibilities to construct timing analysis for complex cyber-physical real-time systems from formal   properties. The target properties should be modular so that safe a",{"id":998,"funder":7,"programme":8,"title":999,"piName":10,"institution":106,"country":53,"year":13,"amount":1000,"abstract":1001},"cordis-european-research-council-award-101002060","A Modular Approach to Multifunctional Red Blood Cell Mimics","€1,988,725","Each year, worldwide 5.6 million people die as a result of trauma. This fact makes uncontrolled bleeding the major cause of preventable death. Additionally, since almost 50% of the traumatic injures affect young people, uncontrolled bleeding has a tremendous social impact and results in an important financial burden to the healthcare system. Donor red blood cells (RBCs) have the ability to restore O2 transport capacity and, as such, blood transfusions are a life-saving procedure for patients who",{"id":1003,"funder":7,"programme":8,"title":1004,"piName":10,"institution":759,"country":176,"year":13,"amount":1005,"abstract":1006},"cordis-european-research-council-award-101001847","March-on-in-Time: Boundary Element Time-Domain Domain Decomposition Methods","€1,999,900","Modelling almost entirely replaced prototyping as a design methodology. In electromagnetics and optics, it has played a central role in the rapid development of communication and imaging, with applications in medicine, security, and energy. New technological requirements have always been met by breakthroughs in modelling.Advances in THz technology have driven researchers to consider systems that are highly non-linear and strongly radiating. Modelling these systems requires methods that are based",{"id":1008,"funder":7,"programme":8,"title":1009,"piName":10,"institution":1010,"country":1011,"year":13,"amount":1012,"abstract":1013},"cordis-european-research-council-award-101002720","Soundscapes of Trauma: Music, Sound and the Ethics of Witnessing","ETHNIKO IDRYMA EREVNON","EL","€1,899,587","MUTE’s main objective is to investigate for the first time empirically and theoretically the use of music and sound in situations of confinement and displacement from the Cold War to contemporary times. It explores their weaponization in light of transnational developments in technologies of terror. At the same time, it carefully attends to how music\u002Fsound can become a tool of survival, even in the same setting in which they are weaponized. Also explored are ethical challenges of such research, ",{"id":1015,"funder":7,"programme":8,"title":1016,"piName":10,"institution":726,"country":203,"year":13,"amount":83,"abstract":1017},"cordis-european-research-council-award-101002582","Nanoengineered magnetoresponsive diagnosis and personalized treatment of pediatric inflammatory bowel disease","Inflammatory bowel disease (IBD) is an incurable, inflammatory condition of the gastrointestinal tract (GIT) that affects millions of patients worldwide and places an enormous economic burden on society. Most alarmingly, children account for one quarter of all IBD cases with steadily increasing incidence. Current clinical practices for IBD diagnosis and therapy are demanding and ineffective in terms of treatment outcome, patient compliance and cost and by far not optimized for children. Our aim ",{"id":1019,"funder":7,"programme":8,"title":1020,"piName":10,"institution":583,"country":474,"year":13,"amount":83,"abstract":1021},"cordis-european-research-council-award-101001613","Post-transcriptional and post-translational mechanisms underlying B cell selection by T cells in germinal centers","Enduring protection from pathogens and robust responses to vaccination depend on the generation of high-affinity antibodies through the germinal center (GC) reaction. In GCs, T helper cells promote the extensive proliferation of high-affinity B cell clones and their differentiation into plasma cells through cellular interactions that modulate gene expression.  Here, we aim to unravel multiple post-gene expression mechanisms, including mRNA and protein stability regulation, that jointly control t",{"id":1023,"funder":7,"programme":8,"title":1024,"piName":10,"institution":1025,"country":834,"year":13,"amount":1026,"abstract":1027},"cordis-european-research-council-award-101001710","A Transnational History of Romanian Literature","UNIVERSITATEA LUCIAN BLAGA DIN SIBIU","€1,450,000","Demographic trends and the epistemic mutations of the past decades have led to numerous critiques of the nationalist-organicist model of literary history. Furthermore, the ethnic status of the individuals identifying as Romanians has become increasingly complex upon increased migration and the emergence of a new state where they amount to an important share of the total population (Moldova).Consequently, a series of questions are yet to be properly explored and answered: How could and should a t",{"id":1029,"funder":7,"programme":8,"title":1030,"piName":10,"institution":195,"country":196,"year":13,"amount":499,"abstract":1031},"cordis-european-research-council-award-101002391","Chromosome-based mechanisms of transcriptional inactivation during mitosis","Coordination between major cellular functions, such as transcription and proliferation, is critical to ensure cell survival. It has long been recognised that while in mitosis, cells switch-off most of their transcriptional activity. While Mitotic Transcriptional Inactivation (MTI) is entrenched as a dogma in cell biology, its functional consequences have been difficult to pin down, as manipulating MTI in the context of a developing organism has been difficult until now. My lab has pioneered the ",{"id":1033,"funder":7,"programme":8,"title":1034,"piName":10,"institution":1035,"country":567,"year":13,"amount":10,"abstract":1036},"cordis-european-research-council-award-101003296","A range-wide transplant experiment using participatory science and genomic prediction to assess local adaptation in forest trees","EIDGENOSSISCHE FORSCHUNGSANSTALT WSL","How organisms adapt to their environments is the most fundamental question in evolutionary biology and is of utmost importance given climate change threats. Identifying key traits involved in adaptations and understanding how they interact with each other, and with the environment, is a particularly urgent task for foundation and resource-production species, such as forest trees. Existing experiments assessing local adaptation lack scalability and predictability in natural environments, especial",{"id":1038,"funder":7,"programme":8,"title":1039,"piName":10,"institution":1040,"country":567,"year":13,"amount":1041,"abstract":1042},"cordis-european-research-council-award-101002845","Post-Quantum Lattice-Based Zero-Knowledge","IBM RESEARCH GMBH","€1,999,510","The world is on a seemingly irreversible path towards a more privacy-oriented and decentralized mode ofstoring and operating on data. A lot of this transformation is being enabled by advanced cryptography that’sdesigned to cut out the need for trusted third parties that we rely on today. The effect of this transformationis a more secure and, at the same time, a more efficient way of interaction in which the manual checks andaudits are instead embedded into the cryptographic protocols themselves.",{"id":1044,"funder":7,"programme":8,"title":1045,"piName":10,"institution":1046,"country":567,"year":13,"amount":1047,"abstract":1048},"cordis-european-research-council-award-101001051","Shimura varieties and the Birch--Swinnerton-Dyer conjecture","FERNUNI SCHWEIZ","€1,739,143","One of the most famous open problems in mathematics is the Birch–Swinnerton-Dyer (BSD) conjecture, which predicts that the size of the set of rational points on an elliptic curve is determined by the order of vanishing at s = 1 of its Hasse–Weil L-function. Building a crucial breakthrough due to Kolyvagin in the 1990's—the discovery of the first example of an  Euler system—the BSD conjecture has now been proved for a wide class of elliptic curves over the rationals: those where the order of vani",{"id":1050,"funder":7,"programme":8,"title":1051,"piName":10,"institution":486,"country":245,"year":13,"amount":1052,"abstract":1053},"cordis-european-research-council-award-101001159","Refined invariants in combinatorics, low-dimensional topology and geometry of moduli spaces","€1,996,023","Some invariants appearing in low-dimensional topology and algebraic geometry admit a so-called refinement: a much stronger, but more complicated invariant. For instance, in low-dimensional topology we study the Poincare polynomial of the triply-graded Khovanov-Rozansky homology of a knot, which is a refined version of the HOMFLY-PT polynomial. The usual Poincare polynomial and the E-polynomial of a character variety are refined by the full mixed Hodge polynomial. On the cohomology of a moduli sp",{"id":1055,"funder":7,"programme":8,"title":1056,"piName":10,"institution":1057,"country":60,"year":13,"amount":1058,"abstract":1059},"cordis-european-research-council-award-101002198","Neural Spectral Image Decoding","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","€1,999,975","Had we the capacity to image the molecular tissue composition in real time, without exposing the patient or clinical staff to radiation, then this would revolutionize healthcare. Spectral imaging techniques, such as multispectral diffuse reflectance imaging and photoacoustics, have the potential to recover important tissue properties including oxygenation, temperature and the concentration of water. However, decades of research invested in solving the inverse problem of reconstructing clinically",{"id":1061,"funder":7,"programme":8,"title":1062,"piName":10,"institution":1063,"country":94,"year":13,"amount":135,"abstract":1064},"cordis-european-research-council-award-101002987","Predicting impacts of alien plant invasions on community diversity","KING'S COLLEGE LONDON","The Anthropocene, the current geological epoch, is characterised by human-induced ecological changes, which have prompted a global biodiversity crisis. Human-introduced alien plants could help to offset native species loss, augmenting diversity and maintaining the services and capital that humans derive from nature. However, alien species that become invasive are themselves a key threat to biodiversity. Alien species thus presents a huge challenge for biodiversity conservation in the Anthropocen",{"id":1066,"funder":7,"programme":8,"title":1067,"piName":10,"institution":227,"country":40,"year":13,"amount":83,"abstract":1068},"cordis-european-research-council-award-101001746","Human mini hearts: looking for culprits and victims in cardiac disease","Cardiac disease causes morbidity and mortality as frequently as cancer. Predicting cardiac arrhythmia and cardiac failure, understanding multicellular (patho)physiological mechanisms, and devising new treatments represent unmet needs in the field. Human induced pluripotent stem cells (hiPSC) could revolutionise the way we study human disease but unfortunately, they still fall short in recapitulating variable phenotypes and complex cardiovascular diseases. This is partly due to functional immatur",{"id":1070,"funder":7,"programme":8,"title":1071,"piName":10,"institution":1072,"country":60,"year":13,"amount":1073,"abstract":1074},"cordis-european-research-council-award-865408","Targeting tubular reabsorption for kidney protection","UNIVERSITATSKLINIKUM HEIDELBERG","€1,945,250","Many forms of chronic kidney disease are featured by the loss of protein into the urine (proteinuria). When the cause of proteinuria lies within the glomerulus, such as in diabetic kidney disease, then the protein overload in the tubular lumen may lead to damage of the downstream tubular cells. Particularly vulnerable are proximal tubular cells (PTCs), because these cells are specialized in protein reabsorption and have a high metabolic demand. Dysfunction of the main albumin uptake receptor cub",{"id":1076,"funder":7,"programme":8,"title":1077,"piName":10,"institution":1078,"country":12,"year":13,"amount":1079,"abstract":1080},"cordis-european-research-council-award-101001694","Information and Misinformation Economics: Design, Manipulations and Coutermeasures","FONDATION NATIONALE DES SCIENCES POLITIQUES","€1,372,381","Informational environments are largely endogenous. They can be, and often are, chosen or designed by individuals or organizations with specific objectives in mind. As recognized by a large literature in economics, information plays a crucial role in shaping the outcome of downstream decisions by strategic players (i.e. at the receiving end of informative signals). However, the structure of information also impacts decisions by strategic agents upstream of the generation of signals, as agents mou",{"id":1082,"funder":7,"programme":8,"title":1083,"piName":10,"institution":1084,"country":567,"year":13,"amount":272,"abstract":1085},"cordis-european-research-council-award-101001652","Tumor-lock: forbid the generation of circulating tumor cells","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","One woman in eight is destined to develop breast cancer. All women that lose their battle against breast cancer vividly realize that its most deadly feature is not the primary lesion, but its ability to spread to distant sites and become an incurable, metastatic disease. In this proposal, we aim to address what is arguably the most ambitious challenge in the cancer field: metastasis prevention.Metastatic spread of cancer occurs through the generation and hematogenous dissemination of circulating",{"id":1087,"funder":7,"programme":8,"title":1088,"piName":10,"institution":292,"country":134,"year":13,"amount":83,"abstract":1089},"cordis-european-research-council-award-101002507","Mathematical and Numerical Modelling of Process-Structure Interaction in Fractured Geothermal Systems","In the development and production of high-temperature geothermal resources, large induced gradients in pressure and temperature during injection operations results in complex dynamics. This includes boiling of geothermal fluids and deformation of the fractured rock, dynamics that are currently not well understood. This provides a core motivation as well as challenging test cases for the mathematical and numerical developments in the MaPSI project. MaPSI has as its main objective to provide mathe",{"id":1091,"funder":7,"programme":8,"title":1092,"piName":10,"institution":1093,"country":169,"year":13,"amount":1094,"abstract":1095},"cordis-european-research-council-award-101003431","Semantics-empowered Wireless Connectivity: Theoretical and Algorithmic Foundations","UNIVERSIDAD DE GRANADA","€1,991,598","Wireless connectivity is traditionally viewed as an opaque data pipe carrying content and messages, whose meaning, impact upon receipt, and usefulness for achieving a goal, have been deliberately set aside. This paradigm, although suitable for classical communication, is inefficient and inadequate to support the data-intensive and timely communication needs of networked intelligent systems. Generating, processing, and attempting to send an excessive amount of distributed real-time data, which en",{"id":1097,"funder":7,"programme":8,"title":1098,"piName":10,"institution":1099,"country":158,"year":13,"amount":83,"abstract":1100},"cordis-european-research-council-award-866494","Magneto-Acoustically Engineered Steerable Robots","UNIVERSITEIT TWENTE","Manual insertion of rigid and unactuated probes are commonly used during minimally invasive surgery (MIS) for delivering diagnostic agents and performing therapeutic interventions. These agents move in an uncontrolled way and are visualized using non-real-time imaging modalities. Controlled release and real-time navigation of these agents would revolutionize MIS and pioneer a myriad of novel clinical interventions, including on-site diagnosis and targeted drug delivery. The goal of MAESTRO is to",{"id":1102,"funder":7,"programme":8,"title":1103,"piName":10,"institution":1104,"country":60,"year":13,"amount":1105,"abstract":1106},"cordis-european-research-council-award-101001179","(Mock) Modular Forms are Everywhere","UNIVERSITAT ZU KOLN","€1,986,017","The main goal of this proposal is to investigate and explain modularity of q-series. Modular forms generalize classical trigonometric functions because they are periodic; however, they have more symmetries. They play a central role in many areas including algebraic topology, arithmetic geometry, combinatorics, mathematical physics, number theory, and representation theory.  The situation is complicated by the fact that often modularity is broken; it is however not always a priori clear in which ",{"id":1108,"funder":7,"programme":8,"title":1109,"piName":10,"institution":1110,"country":12,"year":13,"amount":1111,"abstract":1112},"cordis-european-research-council-award-101002355","Financial Intermediation of Long-Term Savings","ETABLISSEMENT D'ENSEIGNEMENT SUPERIEUR CONSULAIRE HAUTES ETUDES COMMERCIALES DE PARIS","€875,000","Against a backdrop of population aging and secular decline in interest rates, traditional state and occupational pension systems are under stress, forcing households to increasingly rely on their own savings and to bear financial markets risk. Financial intermediaries increasingly take up the role of collecting and investing households’ long-term savings. In the EU, household savings intermediated by life insurers amount to 8 trillion euros or 22% of aggregate household financial wealth. Moreove",{"id":1114,"funder":7,"programme":8,"title":1115,"piName":10,"institution":1116,"country":40,"year":13,"amount":1117,"abstract":1118},"cordis-european-research-council-award-101002280","EGFR signalling talks to mitochondria through contact sites","UNIVERSITA DEGLI STUDI DI MILANO","€1,840,125","The integration of distinct internalization routes is crucial to determine the fate of plasma membrane (PM) receptors and the output of their signalling pathways. Contact sites between cellular organelles adds a further layer of regulation by creating microdomains that favour different signalling and metabolic pathways. These regulatory mechanisms are relevant to the epidermal growth factor receptor (EGFR). We found that EGFR internalization through non-clathrin endocytosis (NCE) leads primarily",{"id":1120,"funder":7,"programme":8,"title":1121,"piName":10,"institution":583,"country":474,"year":13,"amount":1122,"abstract":1123},"cordis-european-research-council-award-101000967","Compressed and Deep Sensing:  Models, Structures, and Tasks","€3,000,000","The sophisticated electronic devices ubiquitous today are largely enabled by conversion of analog signals to digital through digital signal processing (DSP). DSP is also the enabler behind the deep learning revolution, which led to systems with unprecedented performance. However, DSP comes at a cost. Internet traffic has exceeded Zettabytes. The conventional approach to DSP and machine learning is to acquire all data possible and build systems that are capable of massive training and parallel pr",200,{"programme":8,"total":1126,"withPiName":1127,"firstYear":1128,"lastYear":1129,"countryCount":1130,"perYear":1131,"topInstitutions":1171,"topCountries":1240},4499,349,2014,2027,45,[1132,1134,1137,1140,1143,1146,1149,1152,1154,1157,1160,1163,1166,1169],{"year":1128,"count":1133},303,{"year":1135,"count":1136},2015,335,{"year":1138,"count":1139},2016,322,{"year":1141,"count":1142},2017,327,{"year":1144,"count":1145},2018,403,{"year":1147,"count":1148},2019,300,{"year":1150,"count":1151},2020,277,{"year":13,"count":1153},321,{"year":1155,"count":1156},2022,364,{"year":1158,"count":1159},2023,359,{"year":1161,"count":1162},2024,366,{"year":1164,"count":1165},2025,375,{"year":1167,"count":1168},2026,416,{"year":1129,"count":1170},31,[1172,1175,1178,1181,1184,1187,1190,1192,1194,1197,1199,1202,1205,1207,1209,1212,1215,1218,1221,1224,1226,1229,1232,1235,1238],{"name":1173,"count":1174},"Centre National de la Recherche Scientifique CNRS",229,{"name":1176,"count":1177},"University of Oxford",89,{"name":1179,"count":1180},"Weizmann Institute of Science",78,{"name":1182,"count":1183},"University of Cambridge",77,{"name":1185,"count":1186},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",63,{"name":1188,"count":1189},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",55,{"name":1191,"count":1189},"Institut National de la Sante Et de la Recherche Medicale",{"name":1193,"count":1189},"Kobenhavns Universitet",{"name":1195,"count":1196},"Universiteit Utrecht",51,{"name":1198,"count":1196},"University College London",{"name":1200,"count":1201},"Tel Aviv University",49,{"name":1203,"count":1204},"The Hebrew University of Jerusalem",43,{"name":1206,"count":1204},"Universiteit Gent",{"name":1208,"count":1204},"Universiteit van Amsterdam",{"name":1210,"count":1211},"Ludwig-Maximilians-Universitaet Muenchen",42,{"name":1213,"count":1214},"Technische Universitaet Muenchen",41,{"name":1216,"count":1217},"Eidgenoessische Technische Hochschule Zuerich",40,{"name":1219,"count":1220},"Universitat Wien",39,{"name":1222,"count":1223},"Helsingin Yliopisto",38,{"name":1225,"count":1223},"Technische Universiteit Delft",{"name":1227,"count":1228},"Katholieke Universiteit Leuven",37,{"name":1230,"count":1231},"Universitetet I Oslo",36,{"name":1233,"count":1234},"École Polytechnique Fédérale de Lausanne",34,{"name":1236,"count":1237},"The University of Edinburgh",32,{"name":1239,"count":1170},"Lunds Universitet",[1241,1243,1245,1247,1249,1251,1253,1255,1256,1258,1260,1262,1264,1266,1268,1270,1272,1275,1276,1279,1281,1284,1286,1289,1292],{"name":60,"count":1242},810,{"name":94,"count":1244},559,{"name":12,"count":1246},490,{"name":158,"count":1248},428,{"name":169,"count":1250},315,{"name":40,"count":1252},267,{"name":474,"count":1254},219,{"name":567,"count":1124},{"name":203,"count":1257},170,{"name":176,"count":1259},166,{"name":245,"count":1261},146,{"name":53,"count":1263},127,{"name":538,"count":1265},94,{"name":134,"count":1267},85,{"name":82,"count":1269},82,{"name":196,"count":1271},68,{"name":1273,"count":1274},"GB",47,{"name":710,"count":1231},{"name":1277,"count":1278},"HU",24,{"name":1011,"count":1280},22,{"name":1282,"count":1283},"US",21,{"name":936,"count":1285},20,{"name":1287,"count":1288},"TR",14,{"name":1290,"count":1291},"LU",13,{"name":1293,"count":1294},"EE",8]