[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-consolidator-grant-2022":3,"awarded-stats-erc-consolidator-grant":1141},{"awarded":4,"total":1140},[5,16,22,28,35,42,49,55,61,68,75,81,87,93,100,107,113,120,127,133,138,144,150,156,162,168,174,180,186,193,199,206,213,219,225,231,238,244,250,255,260,266,272,278,284,290,297,303,310,316,321,328,334,339,344,349,355,360,366,371,377,383,389,394,398,404,410,415,420,425,431,436,442,447,453,459,464,470,476,482,488,494,499,505,510,515,519,525,530,536,541,547,552,558,564,570,577,582,588,594,600,605,610,616,622,628,633,637,643,649,654,660,666,670,676,682,687,693,697,703,709,714,720,725,730,737,744,750,755,759,765,769,775,780,786,792,798,804,811,815,819,824,829,835,840,845,850,856,861,865,870,875,880,886,892,897,903,908,914,920,926,932,936,941,946,950,956,961,967,972,978,983,988,994,1000,1005,1012,1018,1024,1029,1034,1040,1045,1050,1055,1059,1064,1069,1074,1079,1084,1090,1095,1100,1106,1112,1117,1122,1129,1134],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-european-research-council-award-erc-2014-cog-project-647473","European Research Council","ERC Consolidator Grant","Role of trade agreements in the global cereal market and implications for virtual water flows","Benedetta Falsetti","Politecnico di Torino","IT",2022,null,"Understanding the dynamics of food trade, which involves a corresponding virtual trade in environmental resources, is relevant for its effects on the environment. Among the socioeconomic factors driving the international food market, trade agreements play a significant yet poorly understood role in facilitating access to worldwide trade. Focusing on the global trade of grain from 1993 to 2015, we investigate the role of trade agreements in activating new linkages and increasing traded volumes an",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":21,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-cog-grant-ult-nems-no-647917","Fully Suspended Nano-beams for Quantum Fluids","Ilya Golokolenov","Institut Néel","FR",{"id":23,"funder":7,"programme":8,"title":24,"piName":25,"institution":26,"country":12,"year":13,"amount":14,"abstract":27},"openalex-european-research-council-award-erc-cog-2017-grant-agreement-no-772261-xfab-","Optothermal Raman Spectroscopy of Black Phosphorus on a Gold Substrate","Emiliano Bonera","University of Milano-Bicocca","With black phosphorus being a promising two-dimensional layered semiconductor for application to electronics and optoelectronics, an issue remains as to how heat diffusion is managed when black phosphorus is interfaced with metals, namely in a typical device heterojunction. We use Raman spectroscopy to investigate how the laser-induced heat affects the phonon modes at the interface by comparing the experimental data with a finite element simulation based on a localized heat diffusion. The best c",{"id":29,"funder":7,"programme":8,"title":30,"piName":31,"institution":32,"country":33,"year":13,"amount":14,"abstract":34},"openalex-european-research-council-award-erc-cog-2019-815128","Multimode Electron Tomography Sheds Light on Synthesis, Structure, and Properties of Complex Metal‐Based Nanoparticles","Luis M. Liz‐Marzán","Ikerbasque","ES","Electron tomography has become a cornerstone technique for the visualization of nanoparticle morphology in three dimensions. However, to obtain in-depth information about a nanoparticle beyond surface faceting and morphology, different electron microscopy signals must be combined. The most notable examples of these combined signals include annular dark-field scanning transmission electron microscopy (ADF-STEM) with different collection angles and the combination of ADF-STEM with energy-dispersiv",{"id":36,"funder":7,"programme":8,"title":37,"piName":38,"institution":39,"country":40,"year":13,"amount":14,"abstract":41},"openalex-european-research-council-award-cog-725172-sirfunct","Chiral Posttranslational Modification to Lysine epsilon-Amino Groups","Carlos Moreno–Yruela","University of Copenhagen","DK","The sophistication of proteomic analysis has revealed that protein lysine residues are posttranslationally modified by a variety of acyl groups. Protein lysine acetylation regulates metabolism, gene expression, and microtubule formation and has been extensively studied; however, the understanding of the biological significance of other acyl posttranslational modifications (PTMs) is still in its infancy. The acylation of lysine residues is either mediated by acyltransferase ‘writer’ enzymes or th",{"id":43,"funder":7,"programme":8,"title":44,"piName":45,"institution":46,"country":47,"year":13,"amount":14,"abstract":48},"openalex-european-research-council-award-darkcomb-cog-ga-771410-","Spectral Interferometry with Frequency Combs","Krishna Twayana","Chalmers University of Technology","SE","In this review paper, we provide an overview of the state of the art in linear interferometric techniques using laser frequency comb sources. Diverse techniques including Fourier transform spectroscopy, linear spectral interferometry and swept-wavelength interferometry are covered in detail. The unique features brought by laser frequency comb sources are shown, and specific applications highlighted in molecular spectroscopy, optical coherence tomography and the characterization of photonic integ",{"id":50,"funder":7,"programme":8,"title":51,"piName":52,"institution":53,"country":33,"year":13,"amount":14,"abstract":54},"openalex-european-research-council-award-erc-cog-2014-646869","Staphylococcus aureus ftnA 3’-Untranslated Region Modulates Ferritin Production Facilitating Growth Under Iron Starvation Conditions","Alejandro Toledo‐Arana","Consejo Superior de Investigaciones Científicas","Iron acquisition and modulation of its intracellular concentration are critical for the development of all living organisms. So far, several proteins have been described to be involved in iron homeostasis. Among them, ferritins act as the major iron storage proteins, sequestering internalized iron and modulating its concentration inside bacterial cells. We previously described that the deletion of the 3’-untranslated region (3’UTR) of the ftnA gene, which codes for ferritin in Staphylococcus aur",{"id":56,"funder":7,"programme":8,"title":57,"piName":58,"institution":59,"country":21,"year":13,"amount":14,"abstract":60},"openalex-european-research-council-award-erc-2020-cog-101001420","TV, computer, tablet and smartphone use and autism spectrum disorder risk in early childhood: a nationally-representative study","Maria Melchior","Inserm","BACKGROUND: Screen media use in early childhood has largely increased in recent years, even more so during the COVID-19 epidemic, and there is much discussion regarding its influence on neurodevelopment, including Autism Spectrum Disorder (ASD). METHODS: We examined the relationship between use of TV, computer, tablet and smartphone at age 2 years and risk of ASD assessed in telephone-based questionnaires among 12,950 children participating in the nationally representative ELFE ('Etude Longitudi",{"id":62,"funder":7,"programme":8,"title":63,"piName":64,"institution":65,"country":66,"year":13,"amount":14,"abstract":67},"openalex-european-research-council-award-cog-615708-micarus","Single-cell transcriptomics provides insights into hypertrophic cardiomyopathy","Eva van Rooij","Royal Netherlands Academy of Arts and Sciences","NL","Hypertrophic cardiomyopathy (HCM) is a genetic heart disease that is characterized by unexplained segmental hypertrophy that is usually most pronounced in the septum. While sarcomeric gene mutations are often the genetic basis for HCM, the mechanistic origin for the heterogeneous remodeling remains largely unknown. A better understanding of the gene networks driving the cardiomyocyte (CM) hypertrophy is required to improve therapeutic strategies. Patients suffering from HCM often receive a septa",{"id":69,"funder":7,"programme":8,"title":70,"piName":71,"institution":72,"country":73,"year":13,"amount":14,"abstract":74},"openalex-european-research-council-award-erc-2019-cog-864195","Direct Conversion of Syngas to Higher Alcohols via Tandem Integration of Fischer–Tropsch Synthesis and Reductive Hydroformylation","Walter Leitner","Max Planck Institute for Chemical Energy Conversion","DE","Abstract The selective conversion of syngas to higher alcohols is an attractive albeit elusive route in the quest for effective production of chemicals from alternative carbon resources. We report the tandem integration of solid cobalt Fischer–Tropsch and molecular hydroformylation catalysts in a one‐pot slurry‐phase process. Unprecedented selectivities (>50 wt %) to C 2+ alcohols are achieved at CO conversion levels >70 %, alongside negligible CO 2 side‐production. The efficient overall t",{"id":76,"funder":7,"programme":8,"title":77,"piName":78,"institution":79,"country":73,"year":13,"amount":14,"abstract":80},"openalex-european-research-council-award-erc-2015-cog-682859","One-shot generalization in humans revealed through a drawing task","Henning Tiedemann","Justus-Liebig-Universität Gießen","Humans have the amazing ability to learn new visual concepts from just a single exemplar. How we achieve this remains mysterious. State-of-the-art theories suggest observers rely on internal 'generative models', which not only describe observed objects, but can also synthesize novel variations. However, compelling evidence for generative models in human one-shot learning remains sparse. In most studies, participants merely compare candidate objects created by the experimenters, rather than gener",{"id":82,"funder":7,"programme":8,"title":83,"piName":84,"institution":85,"country":73,"year":13,"amount":14,"abstract":86},"openalex-european-research-council-award-erc-cog-prodap-817798","Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection","Gabriela Krasteva‐Christ","Saarland University","Constant exposure of the airways to inhaled pathogens requires efficient early immune responses protecting against infections. How bacteria on the epithelial surface are detected and first-line protective mechanisms are initiated are not well understood. We have recently shown that tracheal brush cells (BCs) express functional taste receptors. Here we report that bitter taste signaling in murine BCs induces neurogenic inflammation. We demonstrate that BC signaling stimulates adjacent sensory ner",{"id":88,"funder":7,"programme":8,"title":89,"piName":90,"institution":91,"country":73,"year":13,"amount":14,"abstract":92},"openalex-european-research-council-award-consolidator-grant-2018-2023","Late Quaternary paleoenvironmental reconstructions from sediments of Lake Emanda (Verkhoyansk Mountains, East Siberia)","Andrei Andreev","Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung","ABSTRACT Continuous pollen and chironomid records from Lake Emanda (65°17′N, 135°45′E) provide new insights into the Late Quaternary environmental history of the Yana Highlands (Yakutia). Larch forest with shrubs (alders, pines, birches) dominated during the deposition of the lowermost sediments suggesting its Early Weichselian [Marine Isotope Stage (MIS) 5] age. Pollen‐ and chironomid‐based climate reconstructions suggest July temperatures ( T July ) slightly lower than modern. Gradually increa",{"id":94,"funder":7,"programme":8,"title":95,"piName":96,"institution":97,"country":98,"year":13,"amount":14,"abstract":99},"openalex-european-research-council-award-erc-2016-cog-725034","Use of natural deep eutectic systems as new cryoprotectant agents in the vitrification of mammalian cells","Ana Rita Jesus","Rede de Química e Tecnologia","PT","Abstract In this work we present the potential of Natural Deep Eutectic Systems (NADES) as new vitrification media for the cryopreservation of mammalian cells. Several NADES composed of natural metabolites were prepared and tested as CPAs in two cell lines, L929 and HacaT cells. After the harvesting, cells were mixed with the eutectic systems, and frozen directly into liquid nitrogen to achieve a vitreous state. Then, the cells were thawed and it was observed that NADES were able to exert a sign",{"id":101,"funder":7,"programme":8,"title":102,"piName":103,"institution":104,"country":105,"year":13,"amount":14,"abstract":106},"openalex-european-research-council-award-erc-2015-cog-n-681456","Kinetic asymmetry profiles as a holistic approach to engineer molecular non-equilibrium systems","Emanuele Penocchio","University of Luxembourg","LU","Molecular non-equilibrium systems are appealing for developing artificial life-like systems, holding great promises for the nanotechnology of the future. Yet, their development is slowed by the absence of a straightforward and informative representation under non-equilibrium conditions. Indeed, while potential energy surfaces comprise in principle all the information, they hide the dynamic interplay of multiple reaction pathways underlying non-equilibrium systems, i.e., the degree of kinetic asy",{"id":108,"funder":7,"programme":8,"title":109,"piName":110,"institution":111,"country":98,"year":13,"amount":14,"abstract":112},"openalex-european-research-council-award-cog-magtendon-nr-772817","Bioengineered 3D Living Fibers as In Vitro Human Tissue Models of Tendon Physiology and Pathology","Manuela E. Gomes","University of Minho","Clinically relevant in vitro models of human tissue's health and disease are urgently needed for a better understanding of biological mechanisms essential for the development of novel therapies. Herein, physiological (healthy) and pathological (disease) tendon states are bioengineered by coupling the biological signaling of platelet lysate components with controlled 3D architectures of electrospun microfibers to drive the fate of human tendon cells in different composite living fibers (CLFs). In",{"id":114,"funder":7,"programme":8,"title":115,"piName":116,"institution":117,"country":118,"year":13,"amount":14,"abstract":119},"openalex-european-research-council-award-erc-2020-cog-award-101002225","Intraoperative compensation of magnetic field distortions for fluoroscopic and electromagnetic hybrid navigation","Marco Cavaliere","University College Cork","IE","PURPOSE: Hybrid navigation is a promising technique which combines the benefits of optical or electromagnetic tracking (EMT) and fluoroscopy imaging. Unfortunately, the fluoroscopy system is a source of metallic distortion for the EMT system. In this work, we present a new method for intraoperative calibration and real-time compensation of dynamic field distortions. The method was tested in the presence of a fluoroscopy C-arm, and sub-millimetre errors were obtained after distortion correction. ",{"id":121,"funder":7,"programme":8,"title":122,"piName":123,"institution":124,"country":125,"year":13,"amount":14,"abstract":126},"openalex-european-research-council-award-erc-2016-cog-726380","How Reproducible are Surface Areas Calculated from the BET Equation?","Tomoya Iiyuka","The University of Tokyo","JP","Porosity and surface area analysis play a prominent role in modern materials science. At the heart of this sits the Brunauer-Emmett-Teller (BET) theory, which has been a remarkably successful contribution to the field of materials science. The BET method was developed in the 1930s for open surfaces but is now the most widely used metric for the estimation of surface areas of micro- and mesoporous materials. Despite its widespread use, the calculation of BET surface areas causes a spread in repor",{"id":128,"funder":7,"programme":8,"title":129,"piName":130,"institution":131,"country":47,"year":13,"amount":14,"abstract":132},"openalex-european-research-council-award-erc-2015-cog-683810","SimSearch: A Human-in-The-Loop Learning Framework for Fast Detection of Regions of Interest in Microscopy Images","Ankit Gupta","Uppsala University","OBJECTIVE: Large-scale microscopy-based experiments often result in images with rich but sparse information content. An experienced microscopist can visually identify regions of interest (ROIs), but this becomes a cumbersome task with large datasets. Here we present SimSearch, a framework for quick and easy user-guided training of a deep neural model aimed at fast detection of ROIs in large-scale microscopy experiments. METHODS: The user manually selects a small number of patches representing di",{"id":134,"funder":7,"programme":8,"title":135,"piName":136,"institution":39,"country":40,"year":13,"amount":14,"abstract":137},"openalex-european-research-council-award-erc-2019-cog-863671","Archaeology and social justice in island worlds","Felicia Fricke","Ongoing discussions about the problems of white supremacy and colonialism in archaeology are useful but have not, thus far, fully considered the exacerbated effects of these issues on small islands. In this opinion piece, we, two white women academics from the Global North with extensive experience working in the Dutch Caribbean and the Hawaiian Islands, observe these exacerbated effects in governance, academic hegemony, and community relations, and call for more consideration of the effects of ",{"id":139,"funder":7,"programme":8,"title":140,"piName":141,"institution":142,"country":21,"year":13,"amount":14,"abstract":143},"openalex-european-research-council-award-erc-2018-cog-818625","Imaging the Response to DNA Damage in Heterochromatin Domains","Audrey Chansard","Centre National de la Recherche Scientifique","The eukaryotic genome is assembled in a nucleoprotein complex called chromatin, whose organization markedly influences the repair of DNA lesions. For instance, compact chromatin states, broadly categorized as heterochromatin, present a challenging environment for DNA damage repair. Through transcriptional silencing, heterochromatin also plays a vital role in the maintenance of genomic integrity and cellular homeostasis. It is thus of critical importance to decipher whether and how heterochromati",{"id":145,"funder":7,"programme":8,"title":146,"piName":147,"institution":148,"country":21,"year":13,"amount":14,"abstract":149},"openalex-european-research-council-award-erc-2019-cog-864576","Parallel Screening with \u003Csup>14\u003C\u002Fsup>C‐Labeled Carbon Dioxide: De‐risking the Staudinger‐Aza‐Wittig Reaction**","Davide Audisio","Commissariat à l'Énergie Atomique et aux Énergies Alternatives","Abstract Carbon isotope labeling is a useful technology for tracking the fate of organic compounds in the environment and in living organisms. In this context, the development of robust and general methodologies amenable to the direct functionalization of CO 2 remains a significant task. In this communication, a de‐risking approach was developed to evaluate the robustness of the Staudinger aza‐Wittig sequence for carbon isotope labeling. This technology is based on [ 14 C]CO 2 screening that all",{"id":151,"funder":7,"programme":8,"title":152,"piName":153,"institution":154,"country":21,"year":13,"amount":14,"abstract":155},"openalex-european-research-council-award-erc-cog-2015-ga-648974-p-mem-nmr-","Heteronuclear decoupling with rotor-synchronized phase-alternated cycles","Andrea Simion","Université Claude Bernard Lyon 1","A new heteronuclear decoupling pulse sequence is introduced, dubbed ROtor-Synchronized Phase-Alternated Cycles (ROSPAC). It is based on a partial refocusing of the coherences (spin operator products or cross-terms) [Filip et al., J. Mag. Reson. 176, 2 (2005)] responsible for transverse spin-polarization dephasing, on the irradiation of a large pattern of radio-frequencies, and on a significant minimization of the cross-effects implying 1H chemical-shift anisotropy. Decoupling efficiency is analy",{"id":157,"funder":7,"programme":8,"title":158,"piName":159,"institution":160,"country":66,"year":13,"amount":14,"abstract":161},"openalex-european-research-council-award-erc-2017-cog-771057","Self-rated health when population health is challenged by the COVID-19 pandemic; a longitudinal study","Margot P. van de Weijer","Vrije Universiteit Amsterdam","The coronavirus disease 2019 (COVID-19) pandemic and consequent lockdown measures have had a large impact on people's lives. Recent evidence suggests that self-rated health (SRH) scores remained relatively stable or increased during the pandemic. For the current project, we examine potential changes in the variance decomposition of SRH before and during the COVID-19 pandemic in the Netherlands. We analyse data from the Netherlands Twin Register to examine pre-pandemic SRH scores (N = 16,127), pa",{"id":163,"funder":7,"programme":8,"title":164,"piName":165,"institution":166,"country":73,"year":13,"amount":14,"abstract":167},"openalex-european-research-council-award-cog-646747","Photoelectrochemical Conversion of Dinitrogen to Benzonitrile: Selectivity Control by Electrophile‐ versus Proton‐Coupled Electron Transfer","Sven Schneider","University of Göttingen","Abstract Nitride complexes are key species in homogeneous nitrogen fixation to NH 3 via stepwise proton‐coupled electron transfer (PCET). In contrast, direct generation of nitrogenous organic products from N 2 ‐derived nitrides requires new strategies to enable efficient reductive nitride transfer in the presence of organic electrophiles. We here present a 2‐step protocol for the conversion of dinitrogen to benzonitrile. Photoelectrochemical, reductive N 2 splitting produces a rhenium(V) nitride",{"id":169,"funder":7,"programme":8,"title":170,"piName":171,"institution":172,"country":173,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2017-cog-771431","A neuroimmunometabolic view on the cephalic phase of insulin release","Ana I. Domingos","University of Oxford","GB",{"id":175,"funder":7,"programme":8,"title":176,"piName":177,"institution":178,"country":173,"year":13,"amount":14,"abstract":179},"openalex-european-research-council-award-erc-cog-h2020-725492","Early functional mismatch between breast cancer cells and their tumour microenvironment suppresses long term growth","Victoria Sanz‐Moreno","King's College London","Cancer cells thrive when embedded in a fine-tuned cellular and extracellular environment or tumour microenvironment (TME). There is a general understanding of a co-evolution between cancer cells and their surrounding TME, pointing at a functional connection between cancer cells characteristics and the perturbations induced in their surrounding tissue. However, it has never been formally proven whether this functional connection needs to be set from the start or if aggressive cancer cells always ",{"id":181,"funder":7,"programme":8,"title":182,"piName":183,"institution":184,"country":33,"year":13,"amount":14,"abstract":185},"openalex-european-research-council-award-cog-101001038","The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation","J.M. Carazo","Centro Nacional de Biotecnología","The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies characterizing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 bindi",{"id":187,"funder":7,"programme":8,"title":188,"piName":14,"institution":189,"country":190,"year":13,"amount":191,"abstract":192},"cordis-european-research-council-award-101045516","Electrically driven DNA-origami-based machines","AALTO KORKEAKOULUSAATIO SR","FI","€1,999,318","Inspired both by Nature and the success of macroscopic machines, molecular engineers have been exploring various approaches for the realization of nanoscale artificial molecular machines (AMMs), i.e., molecular constructs capable of controlled mechanical actuation. Despite the great promise of AMMs and the tremendous progress in the field, especially on the synthesis side, multiple conceptual and technical challenges, and open questions, e.g., related to AMMs fabrication, implementation of actua",{"id":194,"funder":7,"programme":8,"title":195,"piName":14,"institution":196,"country":12,"year":13,"amount":197,"abstract":198},"cordis-european-research-council-award-101044703","Debiasing the uncertainties of climate stabilization ensembles","POLITECNICO DI MILANO","€1,995,000","Mathematical models have become central tools in global environmental assessments. To serve society well, climate change stabilization assessments need to capture the uncertainties of the deep future, be statistically sound and track near-term disruptions. Up to now, conceptual, computational and data constraints have limited the quantification of uncertainties of climate stabilization pathways to a narrow set, focused on the current century. The statistical interpretation of scenarios generated",{"id":200,"funder":7,"programme":8,"title":201,"piName":14,"institution":202,"country":203,"year":13,"amount":204,"abstract":205},"cordis-european-research-council-award-101044165","NEGOTIATING SOVEREIGNTY: CHALLENGES OF SECULARISM AND NATION BUILDING IN CENTRAL EASTERN EUROPE SINCE 1780","ELTE HUMAN TUDOMANYOK KUTATOKOZPONTJA","HU","€1,990,500","Why does the modern state, with its claim to sovereignty, care so much about secularization and (re)sacralization? In order to address this question, the project examines the (pre)history of the conflict-ridden relationship between transnational institutions and the modern state and also the players who stood at the point of intersection of the two by analysing the shifts in relations between the state and one of the oldest transnational institutions in the world, the Catholic Church.The project",{"id":207,"funder":7,"programme":8,"title":208,"piName":14,"institution":209,"country":210,"year":13,"amount":211,"abstract":212},"cordis-european-research-council-award-101044852","ASSESSING THE IMPACT OF URGENT MEASURES IN PROTECTING AT-RISK DETAINEES  IN LATIN-AMERICA","UNIVERSITEIT GENT","BE","€1,981,250","Urgent Measures (UMs) are granted by international human rights (HRs) bodies to protect persons in a situation of extreme gravity\u002Furgency. In Latin America, UMs are mostly granted to protect detainees, when their right to life, integrity and\u002For health are in danger of being violated. When a UM is granted, the state is requested to provide detainees with e.g. immediate access to medical care, drinking water, or sanitation. In such cases, UMs may prompt emergency protective actions that can, in th",{"id":214,"funder":7,"programme":8,"title":215,"piName":14,"institution":216,"country":21,"year":13,"amount":217,"abstract":218},"cordis-european-research-council-award-101043272","Hydrogen Bond Networks as Optical Probes","UNITED NATIONS EDUCATIONAL SCIENTIFIC AND CULTURAL ORGANIZATION","€1,523,488","Fluorescence takes place throughout the natural world. Most conventional chemical wisdom proposes that in organic entities, fluorescence occurs in conjugated systems, such as in the aromatics. However, in biological settings, the interaction of light with matter occurs in media built up of dense networks of hydrogen bonds. Recent experiments suggest that it is possible to observe fluorescence from these networks too. This could open the possibility of designing hydrogen-bond networks with enhanc",{"id":220,"funder":7,"programme":8,"title":221,"piName":14,"institution":222,"country":73,"year":13,"amount":223,"abstract":224},"cordis-european-research-council-award-101044249","Rigorous Approximations for Many-Body Quantum Systems","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€1,963,290","From first principles of quantum mechanics, physical properties of many-body quantum systems are usually encoded into Schroedinger equations. However, since the complexity of the Schroedinger equations grows so fast with the number of particles, it is generally impossible to solve them by current numerical techniques. Therefore, in practice approximate theories are often applied, which focus only on some collective behaviors of the systems in question.   The corroboration of such effective model",{"id":226,"funder":7,"programme":8,"title":227,"piName":14,"institution":228,"country":33,"year":13,"amount":229,"abstract":230},"cordis-european-research-council-award-101044612","A Cosmological Lever Arm for Fundamental Physics","INSTITUTO DE FISICA DE ALTAS ENERGIAS","€1,885,000","Key open questions in the boundary of cosmology and fundamental physics can be addressed by studies of the distribution of matter as a function of scale and time (or redshift). While the traditional approach has been to use large galaxy catalogues, during the last decade I have pioneered the use of an alternative probe: 3D correlations in the Lyman-α (Lyα) forest, absorption features in the spectra of high-redshift quasars caused by intervening neutral hydrogen. The Lyα forest provides a unique ",{"id":232,"funder":7,"programme":8,"title":233,"piName":14,"institution":234,"country":235,"year":13,"amount":236,"abstract":237},"cordis-european-research-council-award-101044123","Concentration and threshold phenomena in random graphs and hypergraphs","TEL AVIV UNIVERSITY","IL","€1,621,875","The central theme of this proposal is the enumeration of large structures obeying a family of local constraints.  There are numerous well-studied instances of this general problem in combinatorics, probability theory, and statistical physics.  We propose to study a variety of interrelated open problems, spanning extremal and probabilistic combinatorics, Ramsey theory, and large deviation theory, whose unifying theme is the distribution of copies of a given graph in large random graphs.The first ",{"id":239,"funder":7,"programme":8,"title":240,"piName":14,"institution":241,"country":73,"year":13,"amount":242,"abstract":243},"cordis-european-research-council-award-101044526","Magneto-Acoustic Waves in Complex Spin Systems","RHEINLAND-PFALZISCHE TECHNISCHE UNIVERSITAT","€1,999,406","Spintronic devices perform information storage and processing based on the spin degree of freedom. Materials with complex magnetic order, such as ferrimagnets, antiferromagnets and chiral magnets are promising candidates for next-generation spintronic devices with ultrafast speed, enhanced robustness and unique functionalities. However, several fundamental obstacles prevent their efficient control with established approaches based on magnetic fields and electrical currents.MAWiCS will overcome t",{"id":245,"funder":7,"programme":8,"title":246,"piName":14,"institution":247,"country":33,"year":13,"amount":248,"abstract":249},"cordis-european-research-council-award-101045275","Political Trust in Crisis: Determinants and Solutions","FUNDACION CENTRO DE ESTUDIOS MONETARIOS Y FINANCIEROS","€1,836,250","In the last years, the world has experienced an unprecedented increase in the fraction of people that have lost their confidence in political institutions and have started supporting populist candidates. While a rapidly growing literature in social sciences has investigated this phenomenon, current research methodologies face important limitations. Existing studies have limited measures of political attitudes and provide little evidence on the mechanisms behind the increase in distrust. In this ",{"id":251,"funder":7,"programme":8,"title":252,"piName":14,"institution":253,"country":73,"year":13,"amount":14,"abstract":254},"cordis-european-research-council-award-101043302","Early phases of planetary birth sites -- environmental context and interstellar inheritance","LEIBNIZ-INSTITUT FUR ASTROPHYSIK POTSDAM (AIP)","The aim of this ambitious research project is to produce the most realistic computer simulations of the assembly of gaseous protoplanetary accretion discs, and to understand which of their traits are inherited from and\u002For affected by their direct interstellar context. Owing to ground-breaking instruments such as VLT\u002FSphere or the ALMA telescope array, we now have a first extensive census of disk populations. Moving beyond the core characterisation of relatively isolated disks in the calm Class I",{"id":256,"funder":7,"programme":8,"title":257,"piName":14,"institution":202,"country":203,"year":13,"amount":258,"abstract":259},"cordis-european-research-council-award-101043451","The Diplomacy of Small States in Early Modern South-eastern Europe","€1,979,250","This project aims at producing a synoptic analysis of the foreign policy of small states in early modern South-eastern Europe. For centuries, the rulers of the Crimea, Moldavia and Wallachia, Ragusa, Transylvania, and Cossack Ukraine had to cope with their difficult geo-political situation of being at the borderlands between Christian Europe and the Ottoman Empire. The project will be the first attempt for writing a comparative history on the following questions. 1, What kind of strategies these",{"id":261,"funder":7,"programme":8,"title":262,"piName":14,"institution":263,"country":190,"year":13,"amount":264,"abstract":265},"cordis-european-research-council-award-101043848","dAta-dRiven integrated approaches to CHemIcal safety assessMEnt and Drug dEvelopment","TAMPEREEN KORKEAKOULUSAATIO SR","€2,000,000","Traditional in vivo tesTraditional in vivo tests are hampering the development of new, safe and effective chemicals and drugs. If on one hand we need to ensure that dangerous chemicals do not emerge, on the other, we also need to promote rapid and sustainable innovation to successfully overcome the modern challenges of humankind. Toxicogenomics aims at clarifying the mechanism of action (MOA) of chemicals by using omics assays. The Adverse Outcome Pathways (AOP) concept is also emerging to conte",{"id":267,"funder":7,"programme":8,"title":268,"piName":14,"institution":269,"country":73,"year":13,"amount":270,"abstract":271},"cordis-european-research-council-award-101045437","The CLuster and group Environment as Viewed by eROSITA","EUROPEAN SOUTHERN OBSERVATORY - ESO EUROPEAN ORGANISATION FOR ASTRONOMICAL RESEARCH IN THE SOUTHERN HEMISPHERE","€693,750","Galaxy groups play a crucial role in modern cosmology by providing the key test for the predictions of models of large-scale structure and galaxy formation and evolution. This is because their hot gas content, and thus their X-ray appearance, is determined by the fundamental ingredient of the modern cosmological models, i.e. the feedback of the supermassive black hole hosted by the central galaxy. However, differently from galaxy clusters, within this general framework, the predictions of the ga",{"id":273,"funder":7,"programme":8,"title":274,"piName":14,"institution":275,"country":73,"year":13,"amount":276,"abstract":277},"cordis-european-research-council-award-101043656","3D-assembly of interactive microgels to grow in vitro vascularized, structured, and beating human cardiac tissues in high-throughput","DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV","€2,969,219","Generating 3D in vitro functional tissues and organs in the millimeter scale remains an unmet dream of modern medicine. Irrespective of great efforts in the field of tissue engineering to design injectable\u002Fpipettable hydrogels or implantable\u002Fnon-pipettable scaffolds for 3D cell growth, it is not yet possible to generate functional and personalized tissues with native-like structures and mature blood vessels. The main reason for this limitation is that current materials do not recapitulate the co",{"id":279,"funder":7,"programme":8,"title":280,"piName":14,"institution":281,"country":12,"year":13,"amount":282,"abstract":283},"cordis-european-research-council-award-101043968","Solving the multi-scale problem in materials mechanics: a pathway to chemical design","UNIVERSITA DEGLI STUDI DI MILANO","€952,785","Based on recent conceptual and theoretical advances in the lattice dynamics of real solids, I aim to develop a new generation of computational methods that will revolutionize the way we predict and describe the mechanical response of complex materials. State-of-the-art computational methods to simulate materials and their mechanical behaviour are based on molecular dynamics (MD) with atomistic force-fields. These methods provide an excellent description of the thermodynamically stable phases of ",{"id":285,"funder":7,"programme":8,"title":286,"piName":14,"institution":287,"country":66,"year":13,"amount":288,"abstract":289},"cordis-european-research-council-award-101045225","The Psychological Underpinnings of  Nonpharmaceutical Interventions","STICHTING VU","€1,998,168","Infectious diseases cripple well-being, batter economies, and kill millions annually. These negative consequences can be drastically reduced via nonpharmaceutical interventions (NPIs)  behaviors that reduce the spread of pathogens. A wealth of recent theoretical and empirical work has illuminated how and why disgust intuitively motivates some NPIs, such as avoiding bodily wastes and spoiled foods. However, disgust does little to inhibit transmission via aerosols, respiratory droplets, and fomite",{"id":291,"funder":7,"programme":8,"title":292,"piName":14,"institution":293,"country":294,"year":13,"amount":295,"abstract":296},"cordis-european-research-council-award-101045549","EARLY DETECTION AND INTERVENTION IN SMOLDERING MULTIPLE MYELOMA: POPULATION-BASED SCREENING AND TREATMENT","HASKOLI ISLANDS","IS","€1,998,145","Multiple myeloma (MM) is a bone marrow malignancy that is always preceded by asymptomatic precursor conditions, monoclonal gammopathy of undetermined significance (MGUS) or smoldering MM (SMM). SMM is a more advanced precursor and is associated with a high risk of progression to MM.  More than 94% of MM cases are diagnosed when already at the stage of full-blown malignancy and therefore do not benefit from the impact of early treatment. Recent studies indicate a benefit of early treatment but al",{"id":298,"funder":7,"programme":8,"title":299,"piName":14,"institution":300,"country":73,"year":13,"amount":301,"abstract":302},"cordis-european-research-council-award-101045075","Trimers,Tetramers and molecular BEC","GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER","€1,822,724","A major challenge in physics is to prepare and control increasingly complex physical systems at ultracold temperatures down to the quantum level. Precise control allows analyzing the universal features of the system and, at the same time, enables tackling more complex systems. This development has led from atomic control to few- and many-body quantum systems. Similarly, atomic control has enabled the preparation and study of diatomic molecules - a development the PI of this proposal has signific",{"id":304,"funder":7,"programme":8,"title":305,"piName":14,"institution":306,"country":307,"year":13,"amount":308,"abstract":309},"cordis-european-research-council-award-101045083","Computational Discovery of Numerical Algorithms for Animation and Simulation of Natural Phenomena","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","AT","€1,936,503","Modern numerical algorithms and high performance computing systems are capable of simulating physical systems far more efficiently than those from just few years ago. However, this recent increase in computational power comes with an insatiable demand for complexity and scale: scientists and artists now wish to model textiles at the level of individual fibers and simulate oceans down to the smallest ripple. The typical strategy of analytically deriving integrators and hand-tuning parameters will",{"id":311,"funder":7,"programme":8,"title":312,"piName":14,"institution":313,"country":98,"year":13,"amount":314,"abstract":315},"cordis-european-research-council-award-101045506","Population Trajectories and Cultural Dynamics of late Neanderthals in Far Western Eurasia","UNIVERSIDADE DO ALGARVE","€1,899,696","In recent years, knowledge of the processes involved in the disappearance of the Neanderthals and the successful expansion of our species across Eurasia has substantially increased. Still, the spatiotemporal variability of the presumed mechanisms behind Neanderthals’ demise – climate change, fragile demography, inter-species competition – makes it very challenging to evaluate the replacement at a continental scale. The Iberian Peninsula, due to its cul-de-sac position and the role of its souther",{"id":317,"funder":7,"programme":8,"title":318,"piName":14,"institution":319,"country":47,"year":13,"amount":264,"abstract":320},"cordis-european-research-council-award-101043417","Electrical Modulation of Elastic Moduli","CHALMERS TEKNISKA HOGSKOLA AB","How could a textile change its feel upon the push of a button? While we are accustomed to visual displays and loudspeakers, interactive tactile perception largely eludes our experience. Textiles that change their pliability and texture would allow for communication using our sense of touch. Potential applications abound, from human-machine interfaces for robotics to new forms of virtual reality.To facilitate such a tuneable mechanical response, materials are needed whose stiffness can be altered",{"id":322,"funder":7,"programme":8,"title":323,"piName":14,"institution":324,"country":325,"year":13,"amount":326,"abstract":327},"cordis-european-research-council-award-101044424","Eco-evolutionary dynamics in plant-soil interactions during land use transition: consequences for soil functioning and resilience to drought","TARTU ULIKOOL","EE","€1,999,386","European grasslands have been shaped by millennia of low-intensity management and are unique cultural and biodiversity hotspots providing critical ecosystem services. However, the area of traditionally-managed grassland has declined dramatically during the last century, with land-use intensification on productive soil and abandonment of unfertile land both causing species loss and deterioration of ecosystem services. Recent evidence suggests that land-use change also leads to genetic and phenoty",{"id":329,"funder":7,"programme":8,"title":330,"piName":14,"institution":331,"country":21,"year":13,"amount":332,"abstract":333},"cordis-european-research-council-award-101044361","UNEQUAL EDucation: The Role of Educational Constraints in Shaping Inequalities","FONDATION NATIONALE DES SCIENCES POLITIQUES","€1,862,332","Project UNEQUALED aims to study educational constraints faced by individuals at a stage when they are planning their future investments in human capital. Despite its importance, understanding the determinants of educational choices has been a longstanding challenge for two important reasons. First, it requires broad, representative, data. Secondly, because the environment in which individuals’ educational plans are formed, and adjust, is typically endogenous to their characteristics. I will tack",{"id":335,"funder":7,"programme":8,"title":336,"piName":14,"institution":209,"country":210,"year":13,"amount":337,"abstract":338},"cordis-european-research-council-award-101043552","Conceptualising Processes of Monumental Architectural Creation in the Eastern Mediterranean Bronze Age","€1,876,640","DAEDALOS aims to challenge the predominant metanarrative that uniformly sees monuments as an attribute of centralised, hierarchical political economies and top-down power structures, a view that exerts a strong influence on our understanding of the organisation of Bronze Age Eastern Mediterranean societies. In the 2nd mill. BCE, Mainland Greece, Western Anatolia and the islands of Crete, Cyprus and the Cyclades witness a growing architectural elaboration. Impressive ‘palatial’ monuments are buil",{"id":340,"funder":7,"programme":8,"title":341,"piName":14,"institution":209,"country":210,"year":13,"amount":342,"abstract":343},"cordis-european-research-council-award-101043225","Adaptive Multi-Drug Infusion Control System for General Anesthesia in Major Surgery","€1,927,325","A major challenge in anesthesia is to adapt the drug infusion rates from observed patient response to surgical stimuli. The patient models are based on nominal population characteristic response and lack specific surgical effects. In major surgery (e.g. cardiac, transplant, obese patients) modelling uncertainty stems from significant blood losses, anomalous drug diffusion, drug effect synergy\u002Fantagonism, anesthetic-hemodynamic interactions, etc. This complex optimisation problem requires superhu",{"id":345,"funder":7,"programme":8,"title":346,"piName":14,"institution":306,"country":307,"year":13,"amount":347,"abstract":348},"cordis-european-research-council-award-101044579","Mechanisms of tissue size regulation in spinal cord development","€1,993,094","How the organs of a developing organism achieve their correct size and shape is a fundamental unresolved question in biology. Mammalian embryos possess a remarkable ability to regulate (restore) the correct size of their tissues and organs upon perturbations during early development, yet how this is achieved is unknown. Addressing this question has so far been challenging because it requires a multiscale approach that integrates precise measurements with theoretical frameworks. We are now in an ",{"id":350,"funder":7,"programme":8,"title":351,"piName":14,"institution":352,"country":73,"year":13,"amount":353,"abstract":354},"cordis-european-research-council-award-101045082","Global Estimates for non-linear stochastic PDEs","UNIVERSITAET MUENSTER","€1,948,233","The project is concerned with the global behaviour of solutions to  Stochastic Partial Differential Equations  (SPDEs)  from Mathematical Physics which arise e.g. in the description of scaling limits of interacting particle systems and in the  analysis of Quantum Field Theories. The equations contain noise terms which describe random fluctuations and act on all length scales. In this situation  the presence of a non-linear term can  lead to divergencies.  A subtle renormalisation procedure, whic",{"id":356,"funder":7,"programme":8,"title":357,"piName":14,"institution":358,"country":66,"year":13,"amount":14,"abstract":359},"cordis-european-research-council-award-101044452","Global change impacts on cyanobacterial bloom toxicity","KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW","Harmful cyanobacterial blooms produce toxins that are a major threat to water quality and human health. Blooms increase with eutrophication and are expected to be amplified by climate change. Yet, we lack a mechanistic understanding on the toxicity of blooms, and their response to the complex interplay of multiple global change factors. Bloom toxicity is determined by a combination of mechanisms acting at different ecological scales, ranging from cyanobacterial biomass accumulation in the ecosys",{"id":361,"funder":7,"programme":8,"title":362,"piName":14,"institution":363,"country":73,"year":13,"amount":364,"abstract":365},"cordis-european-research-council-award-101044142","Emerging multifactorial complexity at the geminivirus-host interface","EBERHARD KARLS UNIVERSITAET TUEBINGEN","€1,999,973","Viruses manipulate their host cells to replicate and spread. This manipulation is based on the activity of virus-encoded proteins, limited due to restrictions in genome size imposed by the viral cycle. How the action of these few proteins results in the massive cell reprogramming observed during the infection remains enigmatic. Geminiviruses are plant viruses causing diseases in crops worldwide. Recent results obtained in our lab using the geminivirus Tomato yellow leaf curl virus (TYLCV) indica",{"id":367,"funder":7,"programme":8,"title":368,"piName":14,"institution":263,"country":190,"year":13,"amount":369,"abstract":370},"cordis-european-research-council-award-101043572","Ontologies of Waste: A Relational Study of How Waste Comes to Matter for Humans, Society, and Future","€1,974,800","The future world imagined by the circular economic model is a world without waste, provided that materials and energy circulate efficiently enough through society. The project WasteMatters disrupts the waste-as-resource paradigm prevalent in the circular economy related politics, business, and scholarship alike, and examines our contemporary trashscapes beyond the idea(l) of the eternal redemption of waste. Its novel approach is to analyse the leaky realities of waste as integral to the human co",{"id":372,"funder":7,"programme":8,"title":373,"piName":14,"institution":374,"country":47,"year":13,"amount":375,"abstract":376},"cordis-european-research-council-award-101043387","Enlightening the dark side of the phosphorus cycle in terrestrial ecosystems: Turnover of organic phosphorus in soils","SVERIGES LANTBRUKSUNIVERSITET","€1,930,839","Phosphorus (P) is a macronutrient whose availability strongly affects many processes in terrestrial ecosystems. P is recycled through organic P (OP) decomposition, resulting in the generation of inorganic P available for plant uptake. Despite the importance of this process for P cycling and other related biogeochemical cycles, our understanding of OP decomposition is to date very poor, largely due to the lack of methods to determine the decomposition and turnover of OP in soils. In PHOSCYCLE, I ",{"id":378,"funder":7,"programme":8,"title":379,"piName":14,"institution":380,"country":47,"year":13,"amount":381,"abstract":382},"cordis-european-research-council-award-101043238","Gene expression dosage as a driver of cellular and physiological traits","KUNGLIGA TEKNISKA HOEGSKOLAN","€1,993,059","The expression dosage of a gene is a fundamental determinant of its downstream function at the cellular and organismal level, and its genetic or environmental perturbations are a driving force of most common and rare disease in humans. However, we have limited understanding of the specific shape of dosage-to function-curves for human genes, what factors and mechanisms drive their variation across genes, phenotypes and cellular contexts, and how this contributes to functional architecture of huma",{"id":384,"funder":7,"programme":8,"title":385,"piName":14,"institution":386,"country":47,"year":13,"amount":387,"abstract":388},"cordis-european-research-council-award-101045171","X-chromosome biology and immune health in females","LINKOPINGS UNIVERSITET","€1,998,891","Females have a higher risk for autoimmune disease and lower risk of mortality from infectious disease than males, reflecting a more robust immune response in females against both self-antigens (autoimmunity) and non-self-antigens (infections). Genes that escape the process of X-inactivation (XCI) are present in a higher dose in female cells and many play key roles in T-cell biology. XX-Health will reveal the role of escape genes in mediating sex-differences in T-cell response.  Different cells i",{"id":390,"funder":7,"programme":8,"title":391,"piName":14,"institution":331,"country":21,"year":13,"amount":392,"abstract":393},"cordis-european-research-council-award-101043899","Completing the revolution : Enhancing the reality, the principles, and the impact of economics' credibility revolution","€1,197,632","Applied economists routinely evaluate the effect of economic policies. For instance, what is the effect of raising the minimum wage on employment? Angrist & Pischke (2010) argue that applied economics has recently experienced a credibility revolution'': by switching to transparent methods to evaluate policies, applied economists have increased the credibility of their findings, and the impact of their work.In the first part of this proposal, I show that the credibility revolution is not complete",{"id":395,"funder":7,"programme":8,"title":396,"piName":14,"institution":209,"country":210,"year":13,"amount":264,"abstract":397},"cordis-european-research-council-award-101045156","ModulatIng Cancer therapy RespOnse using Bacterial Extracellular nanovesicles","Emerging evidence from cancer patients and mouse models indicates that gut bacteria affect response to immune checkpoint inhibitors (ICI). As a result, modification of gut bacteria by dietary changes, probiotics and fecal transplantations are explored but a huge gap remains to gain clinical application. Limiting factors are the lack of mechanistic knowledge on how gut bacteria impact ICI response, the need of antibiotics to treat infections in cancer patients and gut resilience to exogenous bact",{"id":399,"funder":7,"programme":8,"title":400,"piName":14,"institution":401,"country":98,"year":13,"amount":402,"abstract":403},"cordis-european-research-council-award-101044244","Fishing Architecture: The Ecological Continuum between Buildings and Fish Species","UNIVERSIDADE DO PORTO","€2,001,468","To what extent can fish produce architecture? This project sets out to trace a socioecological history of North Atlantic architecture in relation to fisheries, elucidating the relationships between marine environments and terrestrial landscapes and assessing the ecological impact of fishing constructions and the natural resources they depend upon. Fishing Architecture covers a broad spectrum in terms of both geography and time, a choice that was made to avoid deterministic analysis and engage wi",{"id":405,"funder":7,"programme":8,"title":406,"piName":14,"institution":407,"country":66,"year":13,"amount":408,"abstract":409},"cordis-european-research-council-award-101043229","Three-Dimensional Integrated Photonic-Phononic Circuit","UNIVERSITEIT TWENTE","€2,558,750","The coherent optomechanical interaction between acoustic and optical waves known as stimulated Brillouin scattering (SBS) can enable ultra-high resolution signal processing and narrow linewidth lasers important for next-generation wireless communications, precision sensing, quantum information processing, and many more. But the proliferation of such a unique and powerful technology is currently impeded by fundamental challenges associated with circuit integration of Brillouin optomechanics in a ",{"id":411,"funder":7,"programme":8,"title":412,"piName":14,"institution":386,"country":47,"year":13,"amount":413,"abstract":414},"cordis-european-research-council-award-101045098","Electrically Pumped Perovskite Lasers","€1,834,375","Electrically pumped lasers are considered as a holy grail in the field of optoelectronics. Despite the success of lasers based on expensive epitaxially grown semiconductors, low-cost solution-processed semiconductors provide new opportunities to significantly expand the applications of lasers. On one hand, low-cost and scalable deposition can meet increasing demand of using lasers in consumer electronics. On the other hand, solution-processed semiconductors can be easily proceeded into thin film",{"id":416,"funder":7,"programme":8,"title":417,"piName":14,"institution":418,"country":66,"year":13,"amount":14,"abstract":419},"cordis-european-research-council-award-101045057","Mixotrophy: an uncharted carbon flux in the plant world","STICHTING NATURALIS BIODIVERSITY CENTER","Plants need light to grow. They use energy from sunlight to produce organic carbon. However, new findings – including my own work – now hint that up to 35% of all plant species can also obtain carbon from root-associated fungi when light availability is insufficient for growth. This calls into question much of what we thought we knew about how plants survive in the understory. The goal of this project is to determine the frequency and magnitude of this newly discovered form of ‘mixotrophy’ in ou",{"id":421,"funder":7,"programme":8,"title":422,"piName":14,"institution":222,"country":73,"year":13,"amount":423,"abstract":424},"cordis-european-research-council-award-101043235","Natural Language Understanding for non-standard languages and dialects","€1,997,815","Dialects are ubiquitous and for many speakers are part of everyday life. They carry important social and communicative functions. Yet, dialects and non-standard languages in general are a blind spot in research on Natural Language Understanding (NLU). Despite recent breakthroughs, NLU still fails to take linguistic diversity into account. This lack of modeling language variation results in biased language models with high error rates on dialect data. This failure excludes millions of speakers to",{"id":426,"funder":7,"programme":8,"title":427,"piName":14,"institution":428,"country":33,"year":13,"amount":429,"abstract":430},"cordis-european-research-council-award-101044461","Twistoptics: Manipulating Light-Matter Interactions at the Nanoscale with Twisted van der Waals Materials","UNIVERSIDAD DE OVIEDO","€1,999,500","Van der Waals (vdW) materials are ideal platforms to host light at the nanoscale (nanolight) with unprecedented properties such as strong in-plane anisotropy, arbitrarily large momenta and high density of optical states, opening the door to develop planar optical nanodevices compatible with current on-chip technologies. Remarkably, the in-plane anisotropic propagation of nanolight can be steered by stacking two slabs of a vdW material rotated with respect to each other, resulting, for example, i",{"id":432,"funder":7,"programme":8,"title":433,"piName":14,"institution":434,"country":73,"year":13,"amount":264,"abstract":435},"cordis-european-research-council-award-101045765","DeepLearning 2.0: Meta-Learning Qualitatively New Components","ALBERT-LUDWIGS-UNIVERSITAET FREIBURG","Deep  learning  has  revolutionized  many  fields,  such  as  computer  vision,  speech  recognition, natural  language  processing,  and  reinforcement  learning.   This  success  is  based  on  replacing domain-specific hand-crafted features with features that are learned for the particular task at hand.   The  logical  step  to  take  deep  learning  to  the  next  level  is  to  also  (meta-)learn  other hand-crafted elements of the deep learning pipeline. We therefore propose to develop met",{"id":437,"funder":7,"programme":8,"title":438,"piName":14,"institution":439,"country":73,"year":13,"amount":440,"abstract":441},"cordis-european-research-council-award-101043370","How does autophagy rescue stalled ribosomes?","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","€1,999,006","Multiple ribosomes simultaneously move along the mRNAs to translate the genes into proteins. Cellular stress triggers collisions of ribosomes and disrupts protein synthesis. Eukaryotes have evolved multi-tiered quality control mechanisms that monitor ribosomes and rescue them on collision. While much is known about the rescue of cytosolic ribosomes, how the cell rescues stalled endoplasmic reticulum bound (ER-bound) ribosomes remains unknown. We recently discovered that the stalling of ER-bound ",{"id":443,"funder":7,"programme":8,"title":444,"piName":14,"institution":445,"country":33,"year":13,"amount":264,"abstract":446},"cordis-european-research-council-award-101043711","Ocean Crime Narratives:  A polyhedral assessment of hegemonic discourse on environmental crime and harm at sea (1982-present)","UNIVERSITAT DE LES ILLES BALEARS","With the latest international Law of the Sea (UNCLOS 1982), narratives on environmental crimes and harms at sea have changed their views of ocean governance, sustainability, and human rights, and are now shaping an international, hegemonic discourse. A growing, under-examined corpus of contemporary literary and filmic narratives discusses environmental criminality at sea as subject to contested international and state jurisdiction, harmful to oceanic sustainability and threatening human rights, ",{"id":448,"funder":7,"programme":8,"title":449,"piName":14,"institution":450,"country":33,"year":13,"amount":451,"abstract":452},"cordis-european-research-council-award-101043467","Enabling Homomorphic Encryption of Deep Neural Network Models and Datasets in Production Environments","BARCELONA SUPERCOMPUTING CENTER CENTRO NACIONAL DE SUPERCOMPUTACION","€2,680,195","Deep learning (DL) is widely used to solve classification problems previously unchallenged, such as face recognition, and presents clear use cases for privacy requirements. Homomorphic encryption (HE) enables operations upon encrypted data, at the expense of vast data size increase. RAM sizes currently limit the use of HE on DL to severely reduced use cases. Recently emerged persistent memory technology (PMEM) offers larger-than-ever RAM spaces, but its performance is far from that of customary ",{"id":454,"funder":7,"programme":8,"title":455,"piName":14,"institution":456,"country":73,"year":13,"amount":457,"abstract":458},"cordis-european-research-council-award-101043403","Identification of novel diagnostic, predictive and therapeutic strategies in chronic kidney disease","UNIVERSITAETSKLINIKUM AACHEN","€1,999,063","Chronic Kidney Disease (CKD) represents an important medical, social and economic burden with high morbidity and mortality. The prevalence of CKD has reached >10% in the developed world, and CKD globally accounts for more years lived with disability than all neoplasms combined. Therapeutic strategies to treat CKD or tools for risk stratification of patients are limited and the field has produced the fewest translational randomized clinical trials in medicine while diagnosis is still based on inv",{"id":460,"funder":7,"programme":8,"title":461,"piName":14,"institution":462,"country":73,"year":13,"amount":14,"abstract":463},"cordis-european-research-council-award-101041177","Deciphering cellular and viral determinants of lytic HSV-1 infection, latency and reactivation","MEDIZINISCHE HOCHSCHULE HANNOVER","Herpes simplex virus 1 (HSV-1) is an important human pathogen which infects the majority of the world`s population and inflicts a substantial burden of disease. Over the past 10 years, systems biology approaches, to which my lab has provided seminal contributions, have substantially broadened our understanding of the complex interaction of this common pathogen with its human host. However, the underlying molecular mechanisms remain poorly understood and their importance for virus latency and rea",{"id":465,"funder":7,"programme":8,"title":466,"piName":14,"institution":467,"country":73,"year":13,"amount":468,"abstract":469},"cordis-european-research-council-award-101044105","Late Ottoman Palestinians: Social and Cultural Dynamics in an Eastern Mediterranean Society  during the Age of Empire, 1880-1920","RUHR-UNIVERSITAET BOCHUM","€1,996,496","In the Eastern Mediterranean, the four decades between 1880 and 1920 were a time of imperialism, globalisation and Ottoman state building, but also of profound social differentiation, fuelled by an unprecedented degree of human mobility and migration. Therefore, in this period we find the roots of many social formations that have remained relevant until the present. My focus is on the individual and collective practices for coping with various challenges and on census-taking as a social process.",{"id":471,"funder":7,"programme":8,"title":472,"piName":14,"institution":473,"country":73,"year":13,"amount":474,"abstract":475},"cordis-european-research-council-award-101045128","Biomechanical modelling and computational imaging to identify different causes of back pain in large epidemiological studies","KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)","€1,999,993","Chronic back pain is a major burden and source of disability worldwide. It is primarily attributed to different biomechanical factors, but can also have inflammatory, neurological or psychological causes. Clinical findings and conventional imaging cannot reliably distinguish different causes of back pain. In contrast, individual biomechanical models can quantify diverse (pathologic) loading patterns and thus could be used to distinguish different aetiologies of back pain, to better understand in",{"id":477,"funder":7,"programme":8,"title":478,"piName":14,"institution":479,"country":21,"year":13,"amount":480,"abstract":481},"cordis-european-research-council-award-101044479","In situ genetic perturbation of gut bacteria with engineered phage vectors and CRISPR","INSTITUT PASTEUR","€1,999,780","Humans live in a symbiotic relationship with trillions of microorganisms that inhabit our bodies and play an important role in health and disease. There is a growing interest in manipulating the microbiome to improve health, yet we currently lack the knowledge and technology to carry out precise interventions. The objective of this proposal is to enable efficient in situ genetic perturbations of bacteria in the gut environment by developing the next generation of synthetic biology tools based on",{"id":483,"funder":7,"programme":8,"title":484,"piName":14,"institution":485,"country":307,"year":13,"amount":486,"abstract":487},"cordis-european-research-council-award-101044114","The Formal Turn - The Emergence of Formalism in Twentieth-Century Thought","UNIVERSITAT WIEN","€1,987,840","The philosophy of science and logic underwent a wide-ranging formal turn in the first half of the twentieth century. This shift is characterized by a new emphasis on formal methods and the adoption of a general formalist viewpoint towards the disciplines in question. The project will give a first interdisciplinary and comparative study of early contributions to formalism in twentieth-century thought. This general objective will be addressed in terms of three interrelated subprojects. The first s",{"id":489,"funder":7,"programme":8,"title":490,"piName":14,"institution":491,"country":210,"year":13,"amount":492,"abstract":493},"cordis-european-research-council-award-101044048","Model Atmospheres of the Progenitor Stars to Supernovae and Black Holes:  Finally in 3D!","KATHOLIEKE UNIVERSITEIT LEUVEN","€1,995,750","Stars with masses many times that of our Sun are the direct progenitors to cosmic phenomena such as supernova explosions, black holes, and gravitational wave (GW) sources. Through electromagnetic observations we obtain empirical information of such massive stars, however decoding the radiation reaching us through our telescopes is a highly non-trivial exercise. To constrain fundamental properties like temperatures, radii, chemical abundances, and mass loss, the observed radiation is fit by means",{"id":495,"funder":7,"programme":8,"title":496,"piName":14,"institution":497,"country":73,"year":13,"amount":264,"abstract":498},"cordis-european-research-council-award-101044873","Mechanistic models of leukemia-niche interaction using multimodal single cell profiling","EUROPEAN MOLECULAR BIOLOGY LABORATORY","The bone marrow is one of the most dynamic adult stem cell niches containing hematopoietic stem cells and non-hematopoietic mesenchymal stem and stromal cells, which make up the bone marrow niche. The niche regulates the immune system and constitutes a major determinant of chemoresistance in hematological malignancies, including acute myeloid leukemia (AML). Identifying the mechanisms by which AML interacts with its niche will open novel therapeutic avenues.AML is driven and maintained by leukem",{"id":500,"funder":7,"programme":8,"title":501,"piName":14,"institution":502,"country":73,"year":13,"amount":503,"abstract":504},"cordis-european-research-council-award-101044300","Beyond Influence: The Connected Histories of Ethiopic and Syriac Christianity","UNIVERSITY OF HAMBURG","€1,968,500","The innovative BeInf project interrogates the connected histories of Ethiopic and Syriac Christianity in their various complexities and nuances. It accomplishes this task through a series of five discrete, but complementary case studies addressing: 1. Aramaic loanwords in Ethiopic; 2. the so-called Nagran Episode, in which the sixth-century Aksumite ruler Kaleb intervened on behalf of Syriac Christians who were being persecuted in the Arabian peninsula; 3. the Ethiopic Abba Gärima Gospels, inclu",{"id":506,"funder":7,"programme":8,"title":507,"piName":14,"institution":508,"country":235,"year":13,"amount":264,"abstract":509},"cordis-european-research-council-award-101044574","Proteomic Analysis of Cell communication in Tumors","WEIZMANN INSTITUTE OF SCIENCE","Cancer is an enormous biomedical challenge, in part due to the complexity of cancer cell dynamics. The combination of intrinsic genetic alterations and cues from the tumour microenvironment impact the cancer phenotype and create heterogeneous tumours that evolve in space and time. Cancer cells develop distinct phenotypes in diverse tumour regions and different metastatic locations. In addition, cancer progression, metastatic dissemination, and development of therapeutic resistance affect cellula",{"id":511,"funder":7,"programme":8,"title":512,"piName":14,"institution":513,"country":73,"year":13,"amount":264,"abstract":514},"cordis-european-research-council-award-101045661","Beyond Restitution: Heritage, (Dis)Possession and the Politics of Knowledge","FORUM TRANSREGIONALE STUDIEN EV","On the backdrop of ongoing debates to decolonialize museums, BEYONDREST asks if the return of looted art can be regarded as a closure of historical wounds. The project probes the focus on restitution that inadvertently casts dispossessed art in terms of contested property. Instead, BEYONDREST explores what kind of loss dispossessed art engenders, and how this loss has shaped the knowledge production on heritage. It focuses on the interlocution between Western Europe, the Near and Middle East, an",{"id":516,"funder":7,"programme":8,"title":517,"piName":14,"institution":491,"country":210,"year":13,"amount":264,"abstract":518},"cordis-european-research-council-award-101043730","The Significance of Bilingual Manuscripts for Detecting Cross-Language Interaction in the New Testament Tradition","BICROSS is an interdisciplinary project linking Greek, Latin, Syriac, Coptic, Gothic, Armenian and Arabic philology, New Testament textual criticism, manuscript studies, ancient history and digital humanities.Little is known about the bilingual New Testament manuscripts, although translations occur remarkably early. Their physical and textual characteristics, relations, tendencies and impact remain understudied despite their centrality to the understanding of the transmission of the New Testamen",{"id":520,"funder":7,"programme":8,"title":521,"piName":14,"institution":522,"country":98,"year":13,"amount":523,"abstract":524},"cordis-european-research-council-award-101044975","Integrated Niche Theory: linking environmental, compositional and functional change on coral reefs","FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA","€1,999,995","Idea: CoralINT aims to deliver the ability to predict spatio-temporal change in biodiversity and the consequences of this change for ecosystem function. To achieve this aim, I will develop an Integrated Niche Theory linking three niche concepts: Grinnell’s niche (what a species needs), Elton’s niche (what a species does) and niche construction (how the species function changes the environment). The key to this integration lies in how species are sorted along each of the niche axes (environmental",{"id":526,"funder":7,"programme":8,"title":527,"piName":14,"institution":528,"country":21,"year":13,"amount":523,"abstract":529},"cordis-european-research-council-award-101044399","3Dwheat, A 3 Dimensional functional genomics approach to identify hidden targets controlling heat stress and priming in wheat","UNIVERSITE PARIS CITE","In the global warming era, heat stress is a major threat for both yield stability and yield increase. Plants have evolved a variety of sophisticated mechanisms to adapt to challenging environments. Epigenetic regulations allow them to dynamically reprogram their transcription machinery to adapt to an ever-changing environment. Both histone marks and the 3D organization of the chromatin are instrumental for this coordinated regulation of gene expression according to environmental cues. Yet, the o",{"id":531,"funder":7,"programme":8,"title":532,"piName":14,"institution":533,"country":235,"year":13,"amount":534,"abstract":535},"cordis-european-research-council-award-101044516","Fluidic Shaping of Optical Components on Earth and in Space","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","€2,340,000","We propose to develop and demonstrate a new concept that leverages the fundamental physics of interfacial phenomena to rapidly fabricate complex optical components of any size (from millimeters to meters) with sub-nanometer surface roughness, without the need for any mechanical processing such as grinding or polishing. We term our approach ‘Fluidic Shaping’ to describe its core principle – the ability to take a volume of liquid, shape it into a desired form, and finally cure it to obtain a solid",{"id":537,"funder":7,"programme":8,"title":538,"piName":14,"institution":533,"country":235,"year":13,"amount":539,"abstract":540},"cordis-european-research-council-award-101045114","Coding for DNA Storage","€1,999,096","DNA-based storage has attracted significant attention due to recent demonstrations of the viability of storing information in macromolecules. Unlike classical optical and magnetic storage technologies, DNA-based storage does not require electrical supply to maintain data integrity, and given the trends in cost decreases of DNA synthesis and sequencing, it is estimated that within the next decade DNA storage may become a highly competitive archiving technology. However, existing coding solutions ",{"id":542,"funder":7,"programme":8,"title":543,"piName":14,"institution":544,"country":73,"year":13,"amount":545,"abstract":546},"cordis-european-research-council-award-101045217","Evolution on the Nile: Faunal Regionalization and Continuity in the Pleistocene of Sudan","MUSEUM FUR NATURKUNDE - LEIBNIZ-INSTITUT FUR EVOLUTIONS- UND BIODIVERSITATSFORSCHUNG AN DER HUMBOLDT-UNIVERSITAT ZU BERLIN","€1,999,515","Over a century of paleontological investigation in Africa has revealed a rich Pleistocene fossil record that includes the evolution of hominins and their material cultures. However, the vast majority of fossil sites are located in the East African Rift Valley (EARV), and our knowledge is heavily skewed by this geographic bias. Poor continental geographic sampling means we lack an understanding of faunal regional variations, and the role of dispersal and geographic variation in the emergence of m",{"id":548,"funder":7,"programme":8,"title":549,"piName":14,"institution":380,"country":47,"year":13,"amount":550,"abstract":551},"cordis-european-research-council-award-101043998","Discovering novel control strategies for turbulent wings through deep reinforcement learning","€1,999,748","Over the past decades, aviation has become an essential component of today’s globalized world: before the current pandemic of coronavirus disease 2019 (COVID-19), over 100,000 flights took off everyday worldwide, and a number of studies indicate that after the pandemic its relevance in the transportation mix will be similar to that before COVID-19. Aviation alone is responsible for 12% of the carbon dioxide emissions from the whole transportation sector, and for 3% of the total CO2 emissions in ",{"id":553,"funder":7,"programme":8,"title":554,"piName":14,"institution":555,"country":12,"year":13,"amount":556,"abstract":557},"cordis-european-research-council-award-101045534","Pension reforms and healthy ageing in Italy and Europe: quasi-natural experimental analysis of linked health and pension datasets","UNIVERSITA COMMERCIALE LUIGI BOCCONI","€1,880,430","The COVID-19 pandemic has forced many European countries to spend money that they do not have. This is creating unprecedented levels of debt and will inevitably lead to pressure for retrenchment in social welfare, with pensions seen as a key target. While some nations will seek to protect pensions, others will not. How will these pension reforms impact on healthy ageing? Will such reforms pension save money or perversely pass costs onto healthcare and other welfare systems? We propose an ambitio",{"id":559,"funder":7,"programme":8,"title":560,"piName":14,"institution":561,"country":73,"year":13,"amount":562,"abstract":563},"cordis-european-research-council-award-101044738","Discover molecular pathways for marine glyco-Carbon sequestration","UNIVERSITAET BREMEN","€2,277,248","The scientific frontier project C-Quest will study algal sugar polymers - glycans - in the ocean to resolve their contribution to global carbon cycling and sequestration. C-Quest will explore the hypothesis that marine diatoms, which fix similar amounts of carbon as tropical forests on a global scale, secrete glycan types that are stable, meaning harder to degrade for bacteria than other substrates. This stability results in glyco-carbon sequestration removing the greenhouse gas carbon dioxide f",{"id":565,"funder":7,"programme":8,"title":566,"piName":14,"institution":567,"country":33,"year":13,"amount":568,"abstract":569},"cordis-european-research-council-award-101045309","Island TIME-LINES to quantify biodiversity change","UNIVERSITAT AUTONOMA DE BARCELONA","€1,986,196","One of the most exciting and important research questions in ecology and palaeoecology is how fast, where, and why biodiversity is changing; heated debate on the topic within the scientific community reflects observations of apparently heterogeneous rates of change across the world. Biodiversity responses to different types of drivers of change remain underexplored, because to study these phenomena over the necessary span of years (often centuries to millennia) patterns and processes must be inf",{"id":571,"funder":7,"programme":8,"title":572,"piName":14,"institution":573,"country":574,"year":13,"amount":575,"abstract":576},"cordis-european-research-council-award-101044599","Opening new frontiers in multi-scale evolution of collider events: a dual pathway to precision","ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE","CH","€1,993,125","For the decades to come, the pioneering investigation of the fundamental laws of nature at the Large Hadron Collider (LHC) and at future collider experiments will rely on the interpretation of complex scattering events by means of accurate theoretical calculations, which are instrumental to find small signals of elusive new phenomena. These calculations must describe the evolution of the system from the few particles produced in the high-energy scattering to the tens or hundreds of low-energy pa",{"id":578,"funder":7,"programme":8,"title":579,"piName":14,"institution":573,"country":574,"year":13,"amount":580,"abstract":581},"cordis-european-research-council-award-101045813","PREcision Studies with Optically pumped Beams of Exotic Nuclei","€2,184,375","Neutrons are fascinating particles and are important for nuclear structure, tests of the standard model of particle physics, or properties of neutron stars. Unfortunately, they are electrically neutral, so learning about their distribution in nuclei, especially far from stability, is difficult. However, they possess a magnetic moment, which contributes to –and sometimes dominates– the distribution of nuclear magnetization. This project aims to address the challenging question of the distribution",{"id":583,"funder":7,"programme":8,"title":584,"piName":14,"institution":585,"country":190,"year":13,"amount":586,"abstract":587},"cordis-european-research-council-award-101045747","Music as youth empowerment: creating connection to self and others","JYVASKYLAN YLIOPISTO","€1,983,056","Can music solve global challenges, lead to improved connection and empowerment, foster an inclusive society? I introduce music engagement as a ubiquitous daily resource to advance a critical capacity in a modern world: youth ability to connect with self and others. The challenge of assessing music as a human resource is that it functions at emotional, bodily, and situated levels of experience that are difficult to objectively measure. However, such aspects are integral to state-of-the-art concep",{"id":589,"funder":7,"programme":8,"title":590,"piName":14,"institution":591,"country":66,"year":13,"amount":592,"abstract":593},"cordis-european-research-council-award-101043815","Mechanisms at the interface of DNA damage repair and transcription","ACADEMISCH ZIEKENHUIS LEIDEN","€1,999,764","Bulky DNA lesions are a major obstacle during gene transcription by RNA polymerase II enzymes (RNAPII). The stalling of RNAPII at DNA lesions triggers a genome-wide transcriptional arrest. Transcription-coupled repair (TCR) is a specialized DNA repair pathway that selectively removes DNA lesions from actively transcribed genes to restore transcription. Stalled RNAPII at DNA lesions forms a roadblock for advancing DNA replication forks resulting in toxic collisions. The mechanisms that enable the",{"id":595,"funder":7,"programme":8,"title":596,"piName":14,"institution":597,"country":66,"year":13,"amount":598,"abstract":599},"cordis-european-research-council-award-101044764","Crystals of single chirality via non-equilibrium routes","STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN","€2,415,625","The molecular building blocks of life are of only one handedness. Consequently, pharmaceuticals and other bioactive molecules also need to be of one handedness. When such enantiomers crystallize in separate crystals, isolation of the desired handedness is relatively straightforward. Unfortunately, most enantiomers (90-95%) are thermodynamically more stable as racemic compounds with both enantiomers in the crystallographic unit cell, which impedes any such separations. There are currently no meth",{"id":601,"funder":7,"programme":8,"title":602,"piName":14,"institution":597,"country":66,"year":13,"amount":603,"abstract":604},"cordis-european-research-council-award-101043783","Fluorescent Optical Concentration of Uncollimated Sunlight","€2,998,125","There is an urgent need to use solar energy to produce electricity, fuels and chemicals.  However, the highly diffuse nature of sunlight in angle, wavelength and space complicate its high-efficiency, low-cost and scalable conversion. FOCUS will develop thin-films that concentrate sunlight in these three aspects, creating collimated, monochromatic, high-intensity beams that can provide advantages for photovoltaics and photocatalysis. The underlying concept is a radically different design for a lu",{"id":606,"funder":7,"programme":8,"title":607,"piName":14,"institution":608,"country":47,"year":13,"amount":264,"abstract":609},"cordis-european-research-council-award-101043589","Hybridization derived novel patterns of gene expression","LUNDS UNIVERSITET","Hybridization has been documented to the extent where its importance for generating evolutionary novelty can no longer be questioned. In spite of this, we lack an understanding of the evolution of regulation of gene expression in hybrids, and its role in hybridization derived novelty. Gene expression evolves in a stabilizing manner where cis(local)- and trans(distal) regulatory elements co-evolve. As hybridization breaks up co-inheritance of regulatory elements transgressive hybrid expression pa",{"id":611,"funder":7,"programme":8,"title":612,"piName":14,"institution":613,"country":73,"year":13,"amount":614,"abstract":615},"cordis-european-research-council-award-101044662","Integrated simulations of active emulsions in complex environments","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€1,998,334","Biological cells consist of a myriad of interacting biomolecules that collectively arrange in stable structures. For example, molecules undergo phase separation to form so-called biomolecular condensates. We now know that malfunctioning condensates can cause diseases like Alzheimer’s, Parkinson’s, and cancer. Yet, we do not understand how condensates become malfunctioning and how healthy cells control them. Some challenges in understanding condensate dynamics are that cells are heterogeneous, ha",{"id":617,"funder":7,"programme":8,"title":618,"piName":14,"institution":619,"country":66,"year":13,"amount":620,"abstract":621},"cordis-european-research-council-award-101044619","Fashioning Power through South-South Interaction:  Re-thinking Creativity, Authenticity, Cultural Mediation and Consumer  Agency along China-Africa Fashion Value Chains","UNIVERSITEIT VAN AMSTERDAM","€1,996,206","The project investigates how, in the context of the Belt and Road Initiative, Chinas global power is manifested, negotiated and resisted in peoples daily life in a South-South setting using fashion as an exemplary case. Fashion is recognised as a significant economic force globally and one of the most poignant indicators of cross-cultural exchange. By critically examining China-Africa networks of fashion production, trade and consumption, this project will theorise how fashion is created, circul",{"id":623,"funder":7,"programme":8,"title":624,"piName":14,"institution":625,"country":12,"year":13,"amount":626,"abstract":627},"cordis-european-research-council-award-101043954","Federalism and Border Management in Greek Antiquity","UNIVERSITA DEGLI STUDI DI TRENTO","€668,961","\"Federation for Peace in Ancient Greece” is the title of a well-known article published by J.A.O. Larsen in 1944 (Classical Philology 39: 145-62). As the world was being ravaged by war, Larsen wondered about the potential of federalism as a means of conflict resolution. The subject of his study was federal organisations in a broad sense in ancient Greece, but the research clearly stemmed from a question that is today becoming increasingly topical: can federal organisations limit or even eliminat",{"id":629,"funder":7,"programme":8,"title":630,"piName":14,"institution":631,"country":66,"year":13,"amount":523,"abstract":632},"cordis-european-research-council-award-101044076","Fostering social tipping dynamics to Accelerate Sustainability Transitions","TECHNISCHE UNIVERSITEIT EINDHOVEN","Staying within a maximum global warming of 1.5 degrees requires an acceleration of the transition to a low carbon society. Current theory views such sustainability transitions as inevitably slow as they require interdependent changes throughout socio-technical systems. The observation that energy transition scenarios systematically underestimate the diffusion of key technologies challenges this view. Existing models that form the basis for energy transition scenarios do not include the positive ",{"id":634,"funder":7,"programme":8,"title":635,"piName":14,"institution":619,"country":66,"year":13,"amount":264,"abstract":636},"cordis-european-research-council-award-101044355","Site-selective C(sp3)–H functionalization with gaseous reagents using Hydrogen Atom Transfer photocatalysis  in flow","An essential part of synthetic organic chemistry is the conversion of raw materials into highly complex molecules. While traditionally this has been achieved through conversion of functional groups, Nature has developed strategies to deliberately functionalize C–H bonds in organic molecules. Mimicking Nature’s machinery, chemists have developed a diverse set of powerful C–H bond functionalization strategies. However, undirected and selective C–H bond functionalization is still very challenging a",{"id":638,"funder":7,"programme":8,"title":639,"piName":14,"institution":640,"country":73,"year":13,"amount":641,"abstract":642},"cordis-european-research-council-award-101044724","Forecasting and Preventing Human Errors","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","€1,999,629","Human errors remain the main source of incidents. They can lead to fatalities, traffic accidents, or product defects and cause high economic and social cost. While some errors can still be corrected if they are detected in time, many human errors cause high costs as soon as they occur or are even irreversible. In these cases, it is very important to recognize human errors before they occur. The goal of this project is therefore to develop methods based on artificial intelligence that forecast hu",{"id":644,"funder":7,"programme":8,"title":645,"piName":14,"institution":646,"country":40,"year":13,"amount":647,"abstract":648},"cordis-european-research-council-award-101045396","Silicon-Photonics Hot-Electron Light Sources","DANMARKS TEKNISKE UNIVERSITET","€1,962,253","The aim of the SPOTLIGHT project is to design, build, measure, and explore a novel class of light sources based on hot-electron emission in silicon bowtie structures. We will pioneer hitherto unexplored light sources that use strongly enhanced light-matter interaction to dramatically increase the radiative decay rate of hot electrons, i.e., electrons injected in high-energy bands. These high-energy bands do not play a role in light sources today because electrons in solids couple so strongly to ",{"id":650,"funder":7,"programme":8,"title":651,"piName":14,"institution":646,"country":40,"year":13,"amount":652,"abstract":653},"cordis-european-research-council-award-101044339","Choice, necessity or chance? Understanding behaviouR chanGE iN Transport","€1,936,613","Despite various soft and hard measures as well as improved transport technologies, carbon emissions from transport are not decreasing. URGENT will provide the knowledge base for more effective intervention strategies. To this end, the project examines under which individual and contextual circumstances people change their mobility behaviour and what mental mechanisms are involved in these behaviour change processes.The project uses a holistic interdisciplinary approach based on a unique longitud",{"id":655,"funder":7,"programme":8,"title":656,"piName":14,"institution":657,"country":40,"year":13,"amount":658,"abstract":659},"cordis-european-research-council-award-101045643","Ancient genomics and the population history of the Circum-Alpine region","KOBENHAVNS UNIVERSITET","€1,999,958","The prehistoric pile dwellings in and around the Alps constitute one of the most important archaeological archives of human prehistory. Dating from around 5000 to 500 BC, there are over 1000 known sites in the region, 111 of which are listed on UNESCO’s World Heritage List. The sites are mainly located under water, on lake shores, along rivers, or in wetlands, offering exceptional conditions for the preservation of organic materials like wood, plant remains, animal bones, artefacts, and even tex",{"id":661,"funder":7,"programme":8,"title":662,"piName":14,"institution":663,"country":66,"year":13,"amount":664,"abstract":665},"cordis-european-research-council-award-101043732","Bridges in social networks: Harnessing dual identity to improve interethnic relations","UNIVERSITEIT UTRECHT","€1,999,894","Improving relations between ethnic minority and majority groups is one of the most pressing needs in modern societies. This project will test a new theory: that such relations can be improved by minority members who identify with both their ethnic group and the national majority group, because these dual identifiers can create social bridges between communities. However, not all dual identifiers are recognized as such by others, and misperception may undermine the bridging that dual identifiers ",{"id":667,"funder":7,"programme":8,"title":668,"piName":14,"institution":663,"country":66,"year":13,"amount":264,"abstract":669},"cordis-european-research-council-award-101045485","Determining the mechanisms of lipid-targeting antibiotics in intact bacteria","Antimicrobial resistance is a major threat to global health. To combat this threat, new antibiotics with novel binding modes are urgently needed. Ideal candidates could be lipid-targeting antibiotics (LT-antibiotics) that target special lipids that only exist in bacterial, but not in human cell membranes. These drugs kill refractory pathogens without detectable resistance. This has generated huge interest.  So far, the molecular mechanisms of LT-antibiotics have proven elusive due to technical c",{"id":671,"funder":7,"programme":8,"title":672,"piName":14,"institution":673,"country":203,"year":13,"amount":674,"abstract":675},"cordis-european-research-council-award-101043617","Photoelectrosynthetic processes in continuous-flow under concentrated sunlight: combining efficiency with selectivity","SZEGEDI TUDOMANYEGYETEM","€1,999,750","To be the first CO2-neutral continent by 2050, Europe needs to develop and implement disruptive new technologies, based on scientific breakthroughs. In this regard, utilization of CO2 and organic waste as feedstock to generate valuable products will play a key role in turning the chemical industry on a more sustainable, circular path. In the SunFlower project, we are going to demonstrate that two high-value processes (CO2 or CO reduction and glycerol oxidation will be studied first) can be syner",{"id":677,"funder":7,"programme":8,"title":678,"piName":14,"institution":679,"country":40,"year":13,"amount":680,"abstract":681},"cordis-european-research-council-award-101044180","Non-invasive Conduction Velocity Mapping in Brain Networks: A novel imaging framework for axonal fingerprinting of brain connections in health and disease","REGION HOVEDSTADEN","€1,999,994","Axonal bundles in cerebral white matter form the structural basis of functional brain networks, enabling effective integration of neural activity. The axonal connections are not homogenous structures. Axons differ in diameter and myelination, enabling signal conduction at different velocities. This axonal diversity is a clinically relevant microstructural feature, as neurodegenerative or neuroinflammatory processes can affect axon diameters differently.  Recent advances in Magnetic Resonance Ima",{"id":683,"funder":7,"programme":8,"title":684,"piName":14,"institution":491,"country":210,"year":13,"amount":685,"abstract":686},"cordis-european-research-council-award-101045433","Kinetic selectivity in molecular sieve sensors","€2,480,500","Detecting and monitoring volatile organic compounds (VOCs) is an important task with applications ranging from disease diagnosis via breath analysis to monitoring exposure to toxic chemicals. However, in all such applications, selectively measuring specific VOCs is challenging due to their low concentrations and the presence of a multitude of interfering compounds. Since current miniature sensors cannot efficiently distinguish between VOCs, there is a need for a novel technology capable of disti",{"id":688,"funder":7,"programme":8,"title":689,"piName":14,"institution":690,"country":73,"year":13,"amount":691,"abstract":692},"cordis-european-research-council-award-101043676","Dynamic Ions under Nano-Confinement for Porous Membranes with Ultrafast Gas Permeation Control","FREIE UNIVERSITAET BERLIN","€1,995,925","Transport phenomena of molecules and ions inside porous materials are paramount in various fields, ranging from energy storage and transformation to molecular separation. In advanced energy storage devices, like supercapacitors and batteries, ions are confined in small pores. Nanoconfinement effects change the ion properties and enhance the performance, vital for saving resources and energy. So far, the static properties of nanoconfined ions are thoroughly studied but there is little known about",{"id":694,"funder":7,"programme":8,"title":695,"piName":14,"institution":657,"country":40,"year":13,"amount":523,"abstract":696},"cordis-european-research-council-award-101043559","Aneuploidy and Its Impact on Blood Development: Context Matters","Many childhood leukaemias start to develop before birth due to accumulation of mutations during foetal development. Children with trisomy of chromosome 21 (Ts21), also known as Down's Syndrome (DS), have a 500-fold increased chance of developing acute megakaryoblastic leukaemia. It is well known that aneuploidy (an abnormal number of chromosomes) is often associated with leukaemia and is likely to be driving this increased incidence of blood malignancies in children with DS. However, the mechani",{"id":698,"funder":7,"programme":8,"title":699,"piName":14,"institution":700,"country":33,"year":13,"amount":701,"abstract":702},"cordis-european-research-council-award-101045394","Universal processing route for high-performance nanostructured yarns","FUNDACION IMDEA MATERIALES","€1,999,338","Yarns are a natural architecture to assemble small building blocks into macroscopic objects and are thus woven in our history, from fabrics of natural fibres in ancient times to fibres of synthetic polymers developed in the 20th century for lightweight applications. Humankind’s new building blocks are nanomaterials, with superlative properties in all areas (optoelectronic, catalytic, transport, structural) relevant for global challenges related to energy use, storage and conversion. UNIYARNS pro",{"id":704,"funder":7,"programme":8,"title":705,"piName":14,"institution":706,"country":210,"year":13,"amount":707,"abstract":708},"cordis-european-research-council-award-101044649","Reprogramming the reactivity of main-group compounds for capturing and activating methane and dinitrogen","UNIVERSITE DE NAMUR","€1,957,875","The activation of chemical bonds is fundamental to every chemical transformation. While reactions mediated by transition-metal catalysts are known for more than a century, the last decade witnessed spectacular developments in the emerging area of catalysis mediated by non-metallic species. Among these new chemical entities made from earth-abundant and inexpensive main-group elements, Lewis acid-base pairs and bifunctional element\u002Fligand systems mimicking the behavior of transition-metals rapidly",{"id":710,"funder":7,"programme":8,"title":711,"piName":14,"institution":300,"country":73,"year":13,"amount":712,"abstract":713},"cordis-european-research-council-award-101043353","Radical and Radical-Polar Crossover Logic in Terpenoid Synthesis","€1,987,059","The synthesis of complex natural products has shaped the field of organic chemistry, with translational applications spreading further into medicinal, agrochemical, and material sciences. As the largest class of natural products, terpenoids play a variety of roles in mediating antagonistic and beneficial interactions macroscopically, i.e., among organisms, and microscopically, i.e., on a (sub)cellular level. They defend many species of plants, animals, and microorganisms against predators, patho",{"id":715,"funder":7,"programme":8,"title":716,"piName":14,"institution":717,"country":47,"year":13,"amount":718,"abstract":719},"cordis-european-research-council-award-101043485","Porous poly(ionic liquid)s for CO2 capture and simultaneous conversion under ambient conditions","STOCKHOLMS UNIVERSITET","€1,999,444","CO2 capture, storage and utilization is judged critical to mitigate the rapid rise in the atmospheric CO2 concentration. A key problem is the gigantic mass of CO2 emitted, which asks for robust, efficient and economically viable approaches that are currently missing and limited by the lack of suitable materials. To break through this barrier, I aim to develop metal-free dual-function porous poly(ionic liquid)s (DPPs) to capture and convert CO2 under ambient conditions into cyclic carbonates with",{"id":721,"funder":7,"programme":8,"title":722,"piName":14,"institution":723,"country":66,"year":13,"amount":264,"abstract":724},"cordis-european-research-council-award-101044631","Multiple routes to memory for a second language: Individual and situational factors","STICHTING RADBOUD UNIVERSITEIT","Learning a second language (L2) after early childhood is a challenge, and learners differ not only in how well they rise to this challenge, but presumably also in how they do it. For instance, a small minority of talented individuals is able to acquire a near-native accent in L2, despite the fact that the phonetic repertoire normally becomes dedicated to the native language within the first years of life. It seems thus plausible to assume that these learners have access to a different manner of ",{"id":726,"funder":7,"programme":8,"title":727,"piName":14,"institution":723,"country":66,"year":13,"amount":728,"abstract":729},"cordis-european-research-council-award-101044434","Molecular Engineering of Synthetic Motile Systems towards Biological Environments","€2,350,000","The goal of this ERC is to develop synthetic motile systems with cilia-like and flagella-like movement based on supramolecular assemblies of controlled shape, size and morphology. With this strategy, we are addressing the great challenge of developing synthetic systems with the ability to move, sense, adapt at the cellular, tissue and systemic level. The systems developed will then allow us to study the effect of propulsive movement on cellular uptake, targeted transport, external guidance and s",{"id":731,"funder":7,"programme":8,"title":732,"piName":14,"institution":733,"country":734,"year":13,"amount":735,"abstract":736},"cordis-european-research-council-award-101045135","Non-Hermitian Transport in Anderson forbidden land","IDRYMA TECHNOLOGIAS KAI EREVNAS","EL","€1,525,000","This proposal is centered around the recently discovered (by the PI) ground-breaking way of transport in strongly Anderson localized non-Hermitian media. Initially Anderson localization was studied on electrons but it was later realized that photons provide an alternative cleaner route. However, one fundamental problem of photonics is that of inherent material losses. As the paradigm of parity-time symmetric optics indicates, the resolution of this problem is the judicious combination of gain an",{"id":738,"funder":7,"programme":8,"title":739,"piName":14,"institution":740,"country":741,"year":13,"amount":742,"abstract":743},"cordis-european-research-council-award-101045004","Bringing molecular photomagnets to light - achieving magnets through visible light excitation at room temperature","UNIWERSYTET JAGIELLONSKI","PL","€1,751,250","Visible light provided by the Sun is the cleanest energy source one could ever imagine. Harvesting it is crucial for further development of science and technology as well as for reducing the ecological footprint of humanity. The efficient use of the visible spectrum of the Sun can take many forms and the direct photoexcitation of molecules resulting in a dramatic magnetization change - the so called photomagnetic effect - is one of them. In other words, sunlight photons could write, read and era",{"id":745,"funder":7,"programme":8,"title":746,"piName":14,"institution":747,"country":210,"year":13,"amount":748,"abstract":749},"cordis-european-research-council-award-101044243","Tracking epigenetic plasticity in circulating tumor-derived DNA to monitor drug resistance and guide personalized treatment in cancer patients","VIB VZW","€1,998,625","Personalized therapy has revolutionized cancer care during the past decades, but still suffers from frequent drug resistance and relapse. A better understanding of drug resistance mechanisms and their timely tracking and prevention represent areas of urgent clinical unmet need. While novel or clonally selected genetic lesions including DNA mutations and copy number changes are well known causes of therapy failure, emerging evidence supports a role for non-genetic\u002Fepigenetic heterogeneity and pla",{"id":751,"funder":7,"programme":8,"title":752,"piName":14,"institution":306,"country":307,"year":13,"amount":753,"abstract":754},"cordis-european-research-council-award-101044865","Toward an understanding of the brain interstitial system and the extracellular proteome in health and autism spectrum disorders","€1,997,729","Since the ancient Egyptians, the fluid in the brain has been considered a product of spirits, a pathological signature or inert liquid. Even at the turn of the 19th century, when the cerebrospinal fluid (CSF) was first described as a physiological substance, the CSF and the interstitial fluid (ISF), the fluid surrounding all the cells of the brain, were considered solely as a cushion. Only more recently studies have begun to show that the compositions of these fluids can have a marked impact on ",{"id":756,"funder":7,"programme":8,"title":757,"piName":14,"institution":508,"country":235,"year":13,"amount":264,"abstract":758},"cordis-european-research-council-award-101043300","Organ and mutation dependencies shaping the tumor microenvironment","Tumors are ecosystems in which cancer cells interact with diverse cell populations. In each such ecosystem, environmental conditions, cellular compositions and paracrine signaling create a distinct tumor habitat. How much the composition of the habitat is dictated by the organ versus specific mutations in the cancer cells is unknown. If different organs and mutations have common microenvironmental design principles, one could devise more general therapy. Otherwise, therapy must be mutation and o",{"id":760,"funder":7,"programme":8,"title":761,"piName":14,"institution":762,"country":66,"year":13,"amount":763,"abstract":764},"cordis-european-research-council-award-101045236","Dynamic engIneered heart tiSsue to Study intEr-individual susCeptibily and improve Treatment of Heart Failure","ACADEMISCH ZIEKENHUIS GRONINGEN","€1,998,775","The objective of DISSECT-HF is to generate engineered heart tissue (EHT) with the use of human induced pluripotent stem cells (hiPSC) from specific forms of heart failure (HF). It focusses on three etiologies of HF with a clear trigger and a large inter-individual susceptibility (pregnancy induced HF, anthracycline cardiotoxicity and PLN cardiomyopathy) to unravel common pathophysiological mechanisms involved in the development of HF.    The rationale is: - Better understanding of molecular path",{"id":766,"funder":7,"programme":8,"title":767,"piName":14,"institution":717,"country":47,"year":13,"amount":14,"abstract":768},"cordis-european-research-council-award-101044994","From Household Allocations to Global Inequality: New Methods, Facts and Policy Implications","To understand and mitigate economic inequalities, both locally and globally, we need to acknowledge inequalities within households. Yet, in most empirical studies, such intra-household inequalities are disregarded mainly because we lack appropriate measurement tools and data. Not only is this problematic for inequality measurement, this lack of understanding hampers the design of cost-effective poverty reduction and child development policies. This project has five general objectives. First, I w",{"id":770,"funder":7,"programme":8,"title":771,"piName":14,"institution":772,"country":210,"year":13,"amount":773,"abstract":774},"cordis-european-research-council-award-101044957","Local Addressing of Topological Interacting Systems","UNIVERSITE LIBRE DE BRUXELLES","€1,815,546","The LATIS project builds on the latest advances in addressing individual atoms and engineering topological band structures in optical lattices, in view of exploring the rich physics of interacting topological matter with unprecedented control. Ultracold topological matter has recently emerged as a central theme in the realm of quantum gases. By manipulating ultracold atoms in optical lattices, various experimental groups have realized a variety of topological band structures and detected their c",{"id":776,"funder":7,"programme":8,"title":777,"piName":14,"institution":561,"country":73,"year":13,"amount":778,"abstract":779},"cordis-european-research-council-award-101044046","Indirect optical geometry measurement","€1,981,875","Optical metrology is driving our society forward and has strong impacts on manufacturing, mobility, medicine and fundamental science. This is highlighted by the SI revision in 2019 and the Nobel Prize winning microscopy with visible light in the nanometre range in 2014. Optical techniques allow fast and precise geometry measurements, but only if sufficient light energy is reflected from the objects surface to the photo detection unit. For this reason, specific measurement approaches for each sur",{"id":781,"funder":7,"programme":8,"title":782,"piName":14,"institution":783,"country":190,"year":13,"amount":784,"abstract":785},"cordis-european-research-council-award-101043975","Jet Energy Corrections for High-Luminosity LHC","HELSINGIN YLIOPISTO","€1,955,918","The 2020 update of the European Strategy for Particle Physics puts the HL-LHC at the focal point, together with continued innovation in experimental techniques. Its primary goals include searching for new physics at high energy, exploration of the Higgs potential and precision tests of the Standard Model.At a hadron collider such as LHC, practically all measurements rely on jet energy corrections (JEC). Many important benchmark channels, such as top quark decaying to b jets and ud or cs jet pair",{"id":787,"funder":7,"programme":8,"title":788,"piName":14,"institution":789,"country":73,"year":13,"amount":790,"abstract":791},"cordis-european-research-council-award-101045783","Towards a computational account of natural sequential behavior","TECHNISCHE UNIVERSITAT DARMSTADT","€1,964,000","Imagine navigating through your kitchen, walking around your table and chairs, reaching the counter, sliding a cup on the countertop, pouring yourself some coffee, and preparing a sandwich. Such an every-day situation requires a sequence of behaviors involving the sophisticated interplay of perception, attention, cognition, planning, and action, all unfolding in an ambiguous and uncertain world. Yet, although past research in the behavioral sciences has revealed many properties of these constitu",{"id":793,"funder":7,"programme":8,"title":794,"piName":14,"institution":795,"country":73,"year":13,"amount":796,"abstract":797},"cordis-european-research-council-award-101045527","Exploring the expanding universe of RNA-binding proteins in bacteria","JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG","€1,999,625","All organisms use diverse modes of cellular control as they cope with changing environments. Central to these processes are RNA-binding proteins (RBPs) that impact the stability, translation, or localization of bound RNAs. While RBPs typically have distinct RNA-binding domains, a growing number of proteins that lack these domains are found to interact with RNA as well. In prokaryotes, such unconventional RBPs remain largely unexplored, in part because methods for global RNA interactome capture (",{"id":799,"funder":7,"programme":8,"title":800,"piName":14,"institution":801,"country":21,"year":13,"amount":802,"abstract":803},"cordis-european-research-council-award-101044152","Exoplanetary Systems with a Coronagraphic Archive Processing Engine","UNIVERSITE D'AIX MARSEILLE","€1,999,996","Determining the frequency of life in the Universe is one of the main challenges of the next decades. It requires a large high-contrast imager in space such as LUVOIR or HabEx, able to characterize dozens of nearby earth-like planets. The detection of such planets, 10^-10 fainter than their star and lost in the bright and varying glare of the star in the images, is a formidable challenge. In the race to remove the contaminating starlight, both the coronagraphic instrument and the image processing",{"id":805,"funder":7,"programme":8,"title":806,"piName":14,"institution":807,"country":808,"year":13,"amount":809,"abstract":810},"cordis-european-research-council-award-101044629","Emerging cooperative autonomous systems: Information for control and estimation","UNIVERSITY OF CYPRUS","CY","€1,999,686","Nowadays, attention is drawn towards a new generation of intelligent mobile cooperative autonomous systems (CASs), built with increasingly powerful sensors that allow them to cooperate with other autonomous systems and humans, in order to accelerate the industrial ecosystem and better exploit the potential of flexible automation. The cooperation of autonomous systems, which is an emerging technology in many areas (e.g., intelligent transportation systems and factory automation) is done over a wi",{"id":812,"funder":7,"programme":8,"title":813,"piName":14,"institution":608,"country":47,"year":13,"amount":718,"abstract":814},"cordis-european-research-council-award-101043587","Tumor recurrence and therapeutic resistance: exploring and exploiting the post-radiotherapy brain microenvironment for therapeutic opportunities in malignant brain tumors","Gliomas are the most common brain tumors and the highest-grade glioma, glioblastoma (GBM), is arguably the most aggressive tumor type, with no long-term survivors. Patients with GBM are treated with radiotherapy, chemotherapy, surgery, and tumor treating fields. Despite initial response all tumors recur as incurable lesions; there is an urgent need for novel therapeutic approaches for this patient group. The majority of GBMs recur within the treatment field receiving high-dose radiotherapy durin",{"id":816,"funder":7,"programme":8,"title":817,"piName":14,"institution":508,"country":235,"year":13,"amount":264,"abstract":818},"cordis-european-research-council-award-101044318","Deciphering and targeting cellular states in glioblastoma","Cellular heterogeneity is a fundamental property of glioblastoma (GBM) tumors and presents a major barrier for therapeutics. During the past six years we characterized this heterogeneity in glioblastoma, and in other types of glioma, using single cell RNA-seq (scRNA-seq). We found consistent patterns of heterogeneity across patients, such that each tumor harbors multiple subpopulations of cells that resemble neurodevelopmental cell types. The consistency of these cellular states across patients ",{"id":820,"funder":7,"programme":8,"title":821,"piName":14,"institution":462,"country":73,"year":13,"amount":822,"abstract":823},"cordis-european-research-council-award-101044753","Rehabilitation and Diagnosis of Hearing Loss based on Electric Acoustic Interaction","€1,978,875","Hearing loss is the most common sensory deficit in the elderly, and it is becoming a severe social as well as a health problem. Across the whole lifespan, from new-borns to the elderly, hearing loss impairs the exchange of information, thus significantly impacting everyday life, causing loneliness, isolation, dependence, frustration and communication disorders. Cochlear implants (CIs) are hearing prosthetics that stimulate the auditory nerve with electrodes placed inside the cochlea.  CIs are gr",{"id":825,"funder":7,"programme":8,"title":826,"piName":14,"institution":234,"country":235,"year":13,"amount":827,"abstract":828},"cordis-european-research-council-award-101045763","Engineering B cells to fight cancer","€1,996,250","B cells have an important role in the immune response against cancer. Tumor specific B cells in tertiary lymphoid structures and anti-tumor antibodies in the plasma are associated with a favorable prognosis and with an improved response to checkpoint inhibition in different sarcomas and carcinomas. Antigen specific B cells home to tumors and prolong survival in mice, while B cell based vaccines allow durable anti-tumor activity in cervical cancer patients. We have recently demonstrated both ex v",{"id":830,"funder":7,"programme":8,"title":831,"piName":14,"institution":832,"country":73,"year":13,"amount":833,"abstract":834},"cordis-european-research-council-award-101045008","Electrifying Peptide Synthesis for Directed Evolution of Artificial Enzymes","TECHNISCHE UNIVERSITAET MUENCHEN","€1,997,993","Global climate and energy challenges require efficient, robust and scalable catalysts for the conversion of renewable energies. Nature has evolved extremely active catalysts (enzymes) for the conversion of small molecules relevant to energy (H2, CO2, N2). The scalability of these enzymes offers distinct advantages over the rare, precious metals that are currently used in energy conversion. Unfortunately, the enzymes are unable to tolerate the extreme conditions of operating fuel cells or electro",{"id":836,"funder":7,"programme":8,"title":837,"piName":14,"institution":838,"country":40,"year":13,"amount":14,"abstract":839},"cordis-european-research-council-award-101044626","The Evolution of Early Symbolic Behavior","AARHUS UNIVERSITET","Understanding the unique evolutionary trajectory taken by the human species is impossible without appreciation of our special capacities for symbolic cognition and behavior. But how did these capacities evolve during the late Middle Palaeolithic? Within only the last couple of decades, early milestones in human symbolic behavior have been continuously revised as new excavations across the globe challenge previous long-held assumption. However, at the same time we have made little progress in our",{"id":841,"funder":7,"programme":8,"title":842,"piName":14,"institution":843,"country":73,"year":13,"amount":264,"abstract":844},"cordis-european-research-council-award-101045416","Skeletal Muscles Antagonize T Cell Exhaustion in Chronic Viral Infections","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","Although skeletal muscles are not traditionally considered to be constituents of the immune system, the loss of skeletal muscle mass in chronic infection is frequently associated with impaired T cell function, or T cell exhaustion. Whether and how muscles regulate T cell exhaustion is unknown. We found that skeletal muscles antagonized T cell exhaustion in mice chronically infected with lymphocytic choriomeningitis virus (LCMV) clone 13. Spleen-derived exhausted CD8+ skeletal muscle-infiltrating",{"id":846,"funder":7,"programme":8,"title":847,"piName":14,"institution":848,"country":12,"year":13,"amount":14,"abstract":849},"cordis-european-research-council-award-101045605","Induction of NEuromuscular Plasticity for natural motor rehabilitaTION","UNIVERSITA DEGLI STUDI DI BRESCIA","Neurorehabilitation technologies aim to promote functional neural plasticity in patients suffering from neuromuscular disabilities. Non-invasive systems for the magnetic or electrical stimulation of the neural pathways are particularly promising for interfacing directly with the nervous system of the patients and restoring coordinated movements. Despise these potentials, current neurorehabilitation systems have still significant limitations since they usually employ stimulation protocols based o",{"id":851,"funder":7,"programme":8,"title":852,"piName":14,"institution":853,"country":235,"year":13,"amount":854,"abstract":855},"cordis-european-research-council-award-101044990","In Vivo CRISPR-Based Nanoplatform for Gene Editing:  A New Disruptive Avenue for Non-Invasive Treatment of Genetic Brain Diseases","BAR ILAN UNIVERSITY","€2,249,895","Genetic brain diseases are among the most devastating and fatal diseases, typically having only palliative treatments and no cure. The revolutionary CRISPR\u002FCas gene editing technology provides a new horizon and enormous potential for treating such diseases. However, efficient and safe delivery of CRISPR machinery to diseased cells within the brain is one of the greatest challenges in medicine today. Here, I plan to expand far beyond the state-of-the-art, and propose a game-changer approach for t",{"id":857,"funder":7,"programme":8,"title":858,"piName":14,"institution":508,"country":235,"year":13,"amount":859,"abstract":860},"cordis-european-research-council-award-101045613","Deciphering regulatory principles of proteasome heterogeneity and the degradation landscape in cancer","€1,978,750","Proteasome activity is crucial to removal of defective or obsolete proteins, cell signaling and antigen presentation. In cancer, proteasomal degradation was shown to play key roles in tumor growth, antigenicity and response to immunotherapy. Yet, comprehensive analysis of proteasome subunit composition and the degradation landscape in cancer has not been performed to date, rendering our understanding of inter-patient proteasome heterogeneity and proteasome-dependent mechanisms underlying tumor-i",{"id":862,"funder":7,"programme":8,"title":863,"piName":14,"institution":646,"country":40,"year":13,"amount":264,"abstract":864},"cordis-european-research-council-award-101045517","Molecular mimicry as a key parameter shaping T cell immunity","Scientific Challenge: Immunotherapy has revolutionized cancer treatment, yet only a minor fraction of patients respond to frequently used immunotherapeutic treatments. T cell recognition of peptide-major histocompatibility (pMHC) class I complexes is essential to maintain immune surveillance and eliminate cancerous cells. Numerous products of genetic and epigenetic alterations can serve as targets for T cell recognition of cancer,  yet our capacity to predict what MHC-embedded targets T cells ca",{"id":866,"funder":7,"programme":8,"title":867,"piName":14,"institution":625,"country":12,"year":13,"amount":868,"abstract":869},"cordis-european-research-council-award-101045015","Transmission of the human microbiome and its impact on health","€2,394,779","The human microbiome is a key component of our own biology and has important biomedical applications, but while its composition has been studied in depth and linked with several lifestyle and disease factors, it is still highly unknown how its members are acquired, spread, and transmitted across hosts. Our preliminary results suggest that person-to-person microbiome transmission (MT) is extensive and shapes the microbiome according to host interaction networks, leading to the hypothesis that mic",{"id":871,"funder":7,"programme":8,"title":872,"piName":14,"institution":873,"country":73,"year":13,"amount":14,"abstract":874},"cordis-european-research-council-award-101043907","Tales of the Diasporic Ordinary. Aesthetics, Affects, Archives","HUMBOLDT-UNIVERSITAET ZU BERLIN","Migration is almost always framed as the result of exceptional circumstances, as in the 2015 refugee crisis for instance. This impacts the reception of narratives produced by those living in the diaspora. Works by Black and ethnic minority artists are overwhelmingly associated with labels that set them apart from the unmarked norm. These frameworks favour generational models such as the Windrush generation in Britain, so-called guest worker literature in Germany, and ethnic and area studies desi",{"id":876,"funder":7,"programme":8,"title":877,"piName":14,"institution":878,"country":66,"year":13,"amount":14,"abstract":879},"cordis-european-research-council-award-101045612","Poor Prognosis Colorectal Cancers Display Self-sustained Growth by Niche-mimicry","STICHTING AMSTERDAM UMC","Colorectal cancer (CRC) is a heterogeneous disease with widely variable clinical outcomes. I previously contributed to a unifying molecular classification of CRC, the consensus molecular subtypes (CMSs). The mesenchymal subtype (CMS4), representing ~25% of all CRC patients, is characterised by early metastatic dissemination and poor response to therapy. This is often attributed to activated and rich stroma and therefore much attention in the field goes to dissecting the interaction of the mesenc",{"id":881,"funder":7,"programme":8,"title":882,"piName":14,"institution":883,"country":73,"year":13,"amount":884,"abstract":885},"cordis-european-research-council-award-101043969","Isolation, observation and quantification of mechanisms responsible for hydrogen embrittlement by TRITIum based microMEchanics","KARLSRUHER INSTITUT FUER TECHNOLOGIE","€1,994,136","Hydrogen is an indispensable element in the energy transition and expected to be key for decarburization of the European society. Hydrogen embrittlement – recognized and in focus of materials science since almost 150 years – still causes catastrophic failure until today. It is well-understood that all mechanisms of hydrogen embrittlement materialize at the scale of individual defects, such as dislocations, grain- and phase-boundaries. But we are still missing a correlative measurement of the mec",{"id":887,"funder":7,"programme":8,"title":888,"piName":14,"institution":889,"country":21,"year":13,"amount":890,"abstract":891},"cordis-european-research-council-award-101043344","Defining an integrated model of the neural processing of speech in light of its multiscale dynamics","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","€1,861,100","This interdisciplinary project will define an integrated model of speech processing by recording, modelling and manipulating neural oscillatory dynamics during perception of speech defined as a multiscale temporal signal. Dominant models of speech perception describe its underlying neural mechanisms at a static neuroanatomical level, neglecting the cognitive algorithmic and neural dynamic levels of description. These latter can only be investigated by considering the temporal dimension of speech",{"id":893,"funder":7,"programme":8,"title":894,"piName":14,"institution":895,"country":12,"year":13,"amount":14,"abstract":896},"cordis-european-research-council-award-101045746","Hybrid nanostructured systems for sustainable energy storage","CONSIGLIO NAZIONALE DELLE RICERCHE","Humanity will increasingly need safe, clean and always available energy. Thus, having good energy storage systems will be more and more important in the future. Efficient and sustainable rechargeable batteries are required to power portable electronic devices, new hybrid electric vehicles and to store electricity from renewable sources.The mission of HYNANOSTORE is the development of new environment-friendly systems based on that organic molecules which are used in the chemistry of life for the ",{"id":898,"funder":7,"programme":8,"title":899,"piName":14,"institution":900,"country":33,"year":13,"amount":901,"abstract":902},"cordis-european-research-council-award-101045756","Harnessing Stromal Fibroblasts to Reduce Resistance and Improve Colon Cancer Therapeutics","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","€1,999,826","Refractory tumors and emergence of drug resistance are the most important challenges in cancer therapeutics. The non-cancerous determinants of therapeutic response and particularly the role of the tumor microenvironment (TME) in resistance are poorly understood. I previously described the crucial role of cancer-associated fibroblasts (CAFs) in key tumorigenic processes, including matrix remodeling, cancer cell invasion and growth. Importantly, these aggressive CAF phenotypes are controlled by me",{"id":904,"funder":7,"programme":8,"title":905,"piName":14,"institution":900,"country":33,"year":13,"amount":906,"abstract":907},"cordis-european-research-council-award-101044360","Evolutionary Cellular Computing for Environmental Synthetic Biology","€2,131,809","This project will build living evolutionary cellular computers, and showcase them as intelligent bioremediation agents. Current synthetic genetic networks that perform human-defined computations must remain unchanged—as initially designed—in order to perform well. This is a problem, since biological substrate adapts and evolves, compromising durability, robustness, and computing power. We will exploit the intrinsic dynamic features of living systems. ECCO’s biocomputers will be able self-adapt a",{"id":909,"funder":7,"programme":8,"title":910,"piName":14,"institution":911,"country":12,"year":13,"amount":912,"abstract":913},"cordis-european-research-council-award-101043939","Knowledge and manipulation of nature between usefulness and deception in the Arabo-Islamic tradition (9th-15th century)","ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA","€1,943,208","The UseFool project studies the knowledge and manipulation of nature applied to entertainment and fraud, as described in the Arabic technical literature dealing with the practice of charlatans and performers along the streets and in the markets. At the core of UseFool’s textual corpus are four Arabic handbooks composed between the 6th\u002F12th and the 9th\u002F15th century, combined with other sources, such as the handbooks for the inspector of the market that focus on artisanal impostures. The project w",{"id":915,"funder":7,"programme":8,"title":916,"piName":14,"institution":917,"country":21,"year":13,"amount":918,"abstract":919},"cordis-european-research-council-award-101043369","Modelling Enlightenment: Reassembling Networks of Modernity through data-driven research","ECOLE NORMALE SUPERIEURE","€1,997,183","The Enlightenment has long been associated with the rise of modern Europe, and more generally with the concept of a typically European Modernity that took root in its wake. What it means to be ‘modern’ is indelibly bound up with our understanding of the Enlightenment’s core concepts: reason, religious toleration, civic virtue, political liberty, and scientific progress, to name but a few. For some, the Enlightenment is an essentially philosophical matter; for others it was and remains deeply pol",{"id":921,"funder":7,"programme":8,"title":922,"piName":14,"institution":923,"country":21,"year":13,"amount":924,"abstract":925},"cordis-european-research-council-award-101043802","Impact Of The Gut Microbiota On Host Cells Energy Metabolism: Role In Health And In Inflammatory bowel disease","SORBONNE UNIVERSITE","€1,999,265","Inflammatory bowel diseases (IBD), including Crohns disease and ulcerative colitis, are immune-related disorders characterized byinappropriate gut inflammation. Their incidence has increased dramatically in Western countries in recent decades, supporting a rolefor environmental factors. Despite the development of new treatments, IBD are insufficiently controlled in a large proportion ofpatients, inducing an alteration in quality of life and a socioeconomic burden. A better understanding of the p",{"id":927,"funder":7,"programme":8,"title":928,"piName":14,"institution":929,"country":930,"year":13,"amount":264,"abstract":931},"cordis-european-research-council-award-101045289","Retinal Mesh Optoelectronics","KOC UNIVERSITY","TR","Visual sense is vital for all of us. Blindness has severe negative psychological, social, and economical consequences, and degeneration of photoreceptors is a leading cause of it. Photovoltaic retina implants are the current electronic solution to restore vision loss due to photoreceptor degeneration. Since the state-of-the-art implants are based on photodiodes, which face challenges in terms of miniaturization, efficiency, and compatibility with mechanical and structural properties of the retin",{"id":933,"funder":7,"programme":8,"title":934,"piName":14,"institution":889,"country":21,"year":13,"amount":264,"abstract":935},"cordis-european-research-council-award-101044047","Cancer cell plasticity on targeted therapy","Novel cancer molecular-targeted therapies allow to significantly prolong the survival of cancer patients. However, the inevitable acquisition of resistance mechanisms limits the clinical benefit of these treatments. To fully understand how resistance develops, it is crucial to better integrate tumor heterogeneity, cancer cell plasticity and microenvironment changes by applying cutting-edge single cell technologies directly on sequentially sampled biopsies from cancer patients. Additionally, to a",{"id":937,"funder":7,"programme":8,"title":938,"piName":14,"institution":889,"country":21,"year":13,"amount":939,"abstract":940},"cordis-european-research-council-award-101045253","A perturbative approach to model retinal processing of natural scenes","€1,998,280","A major goal of sensory neuroscience is to understand how sensory neurons process natural scenes. Models built from the responses of sensory neurons to simple stimuli do not generalize to predict how complex, natural scene are processed. Even as early as in the retina, this issue is not solved. Deep network models have been proposed to predict the responses of visual neurons to natural stimuli. However, they are still far from being a realistic model of the visual system. First, the sensitivity ",{"id":942,"funder":7,"programme":8,"title":943,"piName":14,"institution":889,"country":21,"year":13,"amount":944,"abstract":945},"cordis-european-research-council-award-101043671","Opioids and insulin secretion:  a new avenue to fight type 2 diabetes","€1,997,915","Type 2 diabetes (T2D) and obesity are leading causes of morbidity and mortality, becoming a major burden on public health. Failure to understand their pathophysiology has frustrated efforts to develop improved therapeutic strategies. T2D and obesity are complex polygenic disorders. Genome-wide association studies have identified hundreds of loci associated with metabolic traits, but they have not led to promising new drug targets, so far. In contrast, the identification and characterization of r",{"id":947,"funder":7,"programme":8,"title":948,"piName":14,"institution":883,"country":73,"year":13,"amount":14,"abstract":949},"cordis-european-research-council-award-101045376","Coded Secrets: Artistic Interventions Hidden in the Digital Fabric","What lies beneath the surface of computational artworks? Online pieces have ‘roots’ that extend much deeper than the flat screen monitors on which we view them – they may even be distributed, occupying multiple sites on the Internet. Nobody has ever been able to see the responsive and connective agency of these works with their own eyes. COSE sets out to reveal the inner workings of code-based artworks, as well as their embeddedness in the various niches of the World Wide Web. Shedding light on ",{"id":951,"funder":7,"programme":8,"title":952,"piName":14,"institution":953,"country":33,"year":13,"amount":954,"abstract":955},"cordis-european-research-council-award-101044072","Foundations for Antitrust and Policy on Digital Platforms","UNIVERSIDAD POMPEU FABRA","€1,191,078","Internet markets tend to concentrate in the hands of a very few large platforms. These platforms have been accused of abusing their monopoly power vis-a-vis their users (consumers, sellers, advertisers) and maintaining the latter through hostile behavior towards potential competitors. They are said to harm users by ‘self-preferencing’, data harvesting, creating 'monopoly positions' and extracting resulting rents with high fees, all the while avoiding competition by acquiring, copying and otherwi",{"id":957,"funder":7,"programme":8,"title":958,"piName":14,"institution":953,"country":33,"year":13,"amount":959,"abstract":960},"cordis-european-research-council-award-101044828","Scalable systems modelling to simulate body-level interplays among non-communicable diseases","€1,998,865","Non-communicable diseases (NCD) that involve load-bearing organs emerge silently according to complex mechanisms that are likely to involve inter-disease systemic communications. Clinical explorations cannot apprehend such intricate emergence, but I postulate that multiscale in silico models can. The digital twin for health has progressed a lot in the last decades, but multi-disease transversal modelling has not happened. It requires unique developments to couple small to large-scale model compo",{"id":962,"funder":7,"programme":8,"title":963,"piName":14,"institution":964,"country":33,"year":13,"amount":965,"abstract":966},"cordis-european-research-council-award-101044225","Evolution of institutional diversity in a changing world: Finding solutions in resilient agricultural systems","UNIVERSIDAD DE ZARAGOZA","€2,627,380","Institutional diversity is considered as important as biological diversity for our long-term survival. Broadly defined as the variety of rules, norms, and strategies that societies use to govern shared resources (e.g., grazing land, forests, irrigation waters), it could enhance our ability to sustainably manage them and to cope with new and unexpected disturbances such as climate change. Surprisingly, a global quantification of institutional diversity and a full understanding of the process by w",{"id":968,"funder":7,"programme":8,"title":969,"piName":14,"institution":970,"country":73,"year":13,"amount":14,"abstract":971},"cordis-european-research-council-award-101044445","CenTral and PeRipheral NervoUs SyStem acTion of GIPR in ObEsity and Diabetes","HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH","Obesity is a major health threat, but efficient pharmacotherapies are yet not available. First demonstrated by us to decrease body weight and hyperglycemia in obese mice, unimolecular co-agonists at the receptors for glucagon-like peptide-1 (GLP-1) and the glucose-dependent insulinotropic polypeptide (GIP) efficiently corrected obesity and type-2 diabetes in recent phase 3 clinical trials. While GLP-1R\u002FGIPR co-agonists are safe and effective, GIP regulation of metabolism remains enigmatic, with ",{"id":973,"funder":7,"programme":8,"title":974,"piName":14,"institution":975,"country":66,"year":13,"amount":976,"abstract":977},"cordis-european-research-council-award-101043486","Terahertz Integral Field Unit with Universal Nanotechnology","TECHNISCHE UNIVERSITEIT DELFT","€2,993,579","The next challenge in millimeter-submillimeter (mm-submm) astronomy is to generate 3D maps of statistically large cosmic volumes with complete spectral information, to uncover the history of cold matter back to the first billion years of the Universe, the evolution of hot matter in galaxy clusters, and the emergence of cosmic large-scale structure from those baryonic materials.Vital for this endeavor is the integral field unit (IFU), which is a 2D array of spectrometers that instantaneously meas",{"id":979,"funder":7,"programme":8,"title":980,"piName":14,"institution":981,"country":40,"year":13,"amount":264,"abstract":982},"cordis-european-research-council-award-101043983","Towards a transdisciplinary demographic theory of birth and death trajectories","SYDDANSK UNIVERSITET","Fertility and mortality fuel population renewal. Fertility theory struggles with a multitude of underlying, entangled dimensions, whereas mortality theory can build on strong regularities. Intriguingly, strong regularities analogous to death begin to emerge for birth, shown with my novel born once—die once approach. The Gompertz Law of death appears to apply to birth as well. The linear rise in record life expectancy seems to be mirrored by a linear rise in record ‘birth expectancy’ over decades",{"id":984,"funder":7,"programme":8,"title":985,"piName":14,"institution":380,"country":47,"year":13,"amount":986,"abstract":987},"cordis-european-research-council-award-101043637","Developing Interaction Design Knowledge and Materials where Technology Touches the Body","€1,861,899","Intimate Touch will re-conceptualise how technologies use touch to interact with us.  Bringing intimacy as a lens on touch inspires us to think about the felt experience of touch, the diversity of places on the body where we will be touched by technology, and the sense that touch can be transformative of our view of ourselves. This project will develop the theory, methods and technologies of Intimate Touch. It will bring together research in Human-Computer Interaction on intimate technologies wi",{"id":989,"funder":7,"programme":8,"title":990,"piName":14,"institution":991,"country":21,"year":13,"amount":992,"abstract":993},"cordis-european-research-council-award-101043854","Heterogeneous integration of imprecise memory devices to enable learning from a very small volume of noisy data","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","€2,874,335","The artificial intelligence community, inspired by the tremendous progress made in neuroscience, has recently proposed powerful algorithms to enable effective real-time decision making based on a limited volume of noisy sensory data. However, implementing such algorithms in low-power devices remains a challenge due to the energy inefficiency that comes from separating logic and memory in current electronic systems. For the past 10 years, research groups have been developing alternative electroni",{"id":995,"funder":7,"programme":8,"title":996,"piName":14,"institution":997,"country":21,"year":13,"amount":998,"abstract":999},"cordis-european-research-council-award-101043268","A climatic or tectonic control on early primate dispersal? A new approach to investigate species dispersal in deep time","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€1,999,773","Recent studies show that the distribution of many modern terrestrial species can be explained by a handful amount of large-scale dispersals and that these episodes will likely become more numerous under climatic stress. However, the underlying mechanisms governing these dispersals remain nebulous. Long-distance dispersals across marine barriers, often referred to sweepstakes dispersals, have always been assumed to be an unpredictable process in which taxa overcome a geographic barrier in a rando",{"id":1001,"funder":7,"programme":8,"title":1002,"piName":14,"institution":997,"country":21,"year":13,"amount":1003,"abstract":1004},"cordis-european-research-council-award-101043588","Solving Conformal Field Theories with the Functional Bootstrap","€1,950,625","Conformal Field Theories (CFTs) have a wide range of experimental and theoretical applications: describing classical andquantum critical phenomena, where they determine critical exponents; as low (or high) energy limits of ordinary quantumfield theories; and as theories of quantum gravity in disguise via the AdS\u002FCFT correspondence.Unfortunately, most interesting CFTs are strongly interacting and difficult to analyse. On the one hand, perturbative andrenormalization group methods usually involve ",{"id":1006,"funder":7,"programme":8,"title":1007,"piName":14,"institution":1008,"country":1009,"year":13,"amount":1010,"abstract":1011},"cordis-european-research-council-award-101043844","Untangling Ediacaran Paleomagnetism to Contextualize Immense Global Change","UNIVERSITETET I OSLO","NO","€1,963,575","The Ediacaran-early Cambrian (~635-520 Ma) was an interval of immense global change with fundamental state shifts occurring in the bio-cryo- and atmosphere. Such changes included the abrupt appearance and rapid diversification of modern metazoan life (the Ediacaran fauna and Cambrian explosion), the end of protracted, global-scale glaciations (Snowball Earth), the rise of atmospheric oxygen to present-day levels, and the perturbation of carbon isotopic records to extremes otherwise unknown to Ea",{"id":1013,"funder":7,"programme":8,"title":1014,"piName":14,"institution":1015,"country":33,"year":13,"amount":1016,"abstract":1017},"cordis-european-research-council-award-101044387","Understanding the host-environmental interactions across the lifespan determining lung function trajectories and COPD","UNIVERSITAT DE BARCELONA","€1,998,319","Chronic Obstructive Pulmonary Disease (COPD) has been traditionally understood as a self-inflicted disease caused by tobacco smoking occurring in old individuals. Over the past few years, however, our group and others have proposed that the pathogenesis of COPD goes beyond smoking, and that there is a range of lung function trajectories through life (trajectome); some of them have roots in early life and can lead to COPD, cardiovascular and metabolic morbidity as well as premature death, while o",{"id":1019,"funder":7,"programme":8,"title":1020,"piName":14,"institution":1021,"country":118,"year":13,"amount":1022,"abstract":1023},"cordis-european-research-council-award-101044276","Quantifying the formation and evolution of the Archaean lithospheric mantle","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","€1,944,116","The formation of the Archean lithosphere was a key event in Earth history, resulting in the construction of the first continents, or cratons. The lithosphere formed by extensive mantle melting, however, there are conflicting models for the environment in which melting took place. Efforts to understand the formation of the cratonic lithosphere are hampered by a lack of quantitative information on the depth of mantle melting and the original thickness of the Archean lithosphere. Exsolved orthopyro",{"id":1025,"funder":7,"programme":8,"title":1026,"piName":14,"institution":1008,"country":1009,"year":13,"amount":1027,"abstract":1028},"cordis-european-research-council-award-101045346","EXamining how Past demography affects genetic LOad using Ancient DNA","€625,229","DNA can survive millennia post-mortem, spanning ecological and evolutionary transitions and providing a unique window into the processes underlying biodiversity. As such sequencing ancient DNA from temporally spaced samples can allow the testing of hypotheses related to evolutionary responses to ecological change and novel selection pressures through direct quantification of ecological and genetic parameters collected before, during and after genetic changes in selection pressures. Here, I propo",{"id":1030,"funder":7,"programme":8,"title":1031,"piName":14,"institution":997,"country":21,"year":13,"amount":1032,"abstract":1033},"cordis-european-research-council-award-101044892","SYNTHESIS AND PROPERTIES OF F-BLOCK ORGANOMETALLICS: EN ROUTE TO THE Φ-BOND","€1,999,226","If the f-elements; rare earths and actinides, have many applications in various fields (catalysis, materials for optics, for magnetism, for energy and quantum technologies), major fundamental questions yet remain to be discovered. The nature of the interactions between the f orbitals, which have a low radial extension, and their surroundings is still in question. Indeed, if the buried-character of f-electrons confers their compounds with some of their properties, this particularly harms the desc",{"id":1035,"funder":7,"programme":8,"title":1036,"piName":14,"institution":1037,"country":33,"year":13,"amount":1038,"abstract":1039},"cordis-european-research-council-award-101042707","Amorphous topological matter: Predicting new phases with enhanced properties in a vast pool of amorphous materials","FUNDACION DONOSTIA INTERNATIONAL PHYSICS CENTER","€1,918,969","Discovering new phases of matter in materials with superior properties is a central goal of condensed matter physics.  Topological phases are a remarkable example: their robust and universal properties are key to groundbreaking technologies, notably robust quantum computation based on topological superconductors. However, our methodology to discover and classify topological materials relies heavily on crystal symmetry, thereby overlooking the largest, most affordable and scalable pool of materia",{"id":1041,"funder":7,"programme":8,"title":1042,"piName":14,"institution":997,"country":21,"year":13,"amount":1043,"abstract":1044},"cordis-european-research-council-award-101045195","The Mysterious Bang: A Language and Population Isolate Unlocks the Secrets of Interior West Africa's Lost Ethnolinguistic Diversity","€1,966,250","Species are often the most diverse at their origins, and all modern humans can trace their origins back to Africa. Our ability to communicate through language defines us; every human being speaks (or signs) at least one language. We may never know when our current forms of language were first spoken, or what speakers sounded like, but we can be assured that primordial languages were spoken in Africa. Yet, a paradox presents itself with respect to the apparent lack of linguistic heterogeneity in ",{"id":1046,"funder":7,"programme":8,"title":1047,"piName":14,"institution":997,"country":21,"year":13,"amount":1048,"abstract":1049},"cordis-european-research-council-award-101043288","Colloidal control of multi-phase flow in geological porous media","€1,998,744","The COCONUT project aims at developing predictive capabilities to understand how colloids (nanometals, fine particles, bacteria, viruses, asphaltenes..) control immiscible two-phase flow in complex geological formations. Colloids (including nanoparticles) have an incredible potential to remobilize non-aqueous phases trapped by capillary forces in soils and the subsurface, and then to remediate contaminated groundwater or to enhance oil recovery. Their use in daily engineering, however, is still ",{"id":1051,"funder":7,"programme":8,"title":1052,"piName":14,"institution":997,"country":21,"year":13,"amount":1053,"abstract":1054},"cordis-european-research-council-award-101043602","Higher-order motor control of stochastic behavior in an uncertain environment","€1,991,725","Decision-making behaviors often occur in the absence of clear instruction to guide action. Instead, theories and experiments have predicted that the brain must compute a decision-value based on past experience to select the best action. This implies that the action with the highest subjective value should always be chosen. However, behavior is often stochastic with variability from trial-to-trial. To resolve this long-standing paradox, MOTORHEAD will take full advantage of state-of-the-art in vi",{"id":1056,"funder":7,"programme":8,"title":1057,"piName":14,"institution":981,"country":40,"year":13,"amount":14,"abstract":1058},"cordis-european-research-council-award-101045149","CONDUCTIVE MINERALS AS ELECTRICAL CONDUITS IN METHANE CYCLING","This proposal aims to gain a fundamental understanding of the impact of anthropogenic conductive particles on methane emissions. We recently showed that conductive particles are vital for the interspecies cross-feeding of a methane-producing consortium from the Baltic Sea. Previous to that, we showed that conductive particles accelerate methane production in synthetic dual-species consortia that typically function via direct electron transfer. Others showed that conductive particles may also sti",{"id":1060,"funder":7,"programme":8,"title":1061,"piName":14,"institution":1008,"country":1009,"year":13,"amount":1062,"abstract":1063},"cordis-european-research-council-award-101045526","The PsychoGeography of Intergenerational Mobility: Early life socioeconomic position, mental health, and educational performance","€2,158,630","Surging inequality is a defining feature of the world children grow up in today. The neighborhood they live in stages a primary developmental context where this feature of our present time plays out. Children’s demographic and socio-economic status (SES) is given by the status of their parents. Parental and neighborhood SES is associated with child mental health and educational performance, and childhood is a vulnerable period. To understand how and why early life socioeconomic position is linke",{"id":1065,"funder":7,"programme":8,"title":1066,"piName":14,"institution":1067,"country":190,"year":13,"amount":264,"abstract":1068},"cordis-european-research-council-award-101043314","Particle distribution dynamics in nonlinear bifurcating networks","OULUN YLIOPISTO","Bifurcating networks are ubiquitous in nature such as vasculature\u002Fpulmonary networks, kidney urinary tract, and branching in plants. In addition to their role of transporting the carrying fluid, these networks distribute discrete particles suspended in the fluid leading to intricate spatiotemporal particle flow dynamics. The heterogenous distribution of red blood cells (RBC) in microcirculation is an example of this behaviour, consequences of which are not well-understood. Our objective is to ex",{"id":1070,"funder":7,"programme":8,"title":1071,"piName":14,"institution":997,"country":21,"year":13,"amount":1072,"abstract":1073},"cordis-european-research-council-award-101044930","Relative Langlands Functoriality, Trace Formulas and Harmonic Analysis","€1,409,559","The Langlands program is a web of vast and far-reaching conjectures connecting seemingly distinct areas of mathematics that are number theory and representation theory. At the heart of this program lies an important principle called functoriality, that postulates the existence of deep relations between the automorphic representations of different groups, as well as related central analytic objects called automorphic L-functions. Recently, a new and particularly promising way to look at these not",{"id":1075,"funder":7,"programme":8,"title":1076,"piName":14,"institution":997,"country":21,"year":13,"amount":1077,"abstract":1078},"cordis-european-research-council-award-101044777","Three dimensional INtegrated PhotonIcS to RevolutionizE deep Learning","€1,998,918","Neural networks revolutionize computation and already outperform humans according to many benchmarks. They have the potential to transform society and have already influenced Google to place artificial intelligence at the core (“AI first”) of business strategy. Governments and policy bodies worldwide focus on neural network-based computing as a vital future technology.Despite the evident promise, however, current architectures severely lose computational efficiency when applied to large neural n",{"id":1080,"funder":7,"programme":8,"title":1081,"piName":14,"institution":997,"country":21,"year":13,"amount":1082,"abstract":1083},"cordis-european-research-council-award-101045750","From Hodge theory to combinatorics and geometry","€1,948,125","We propose an approach to the Dodziuk-Singer conjecture, a central conjecture in geometric topology, specifically concerning the great challenge that understanding aspherical manifolds can pose, based on newly developed tools from combinatorial commutative algebra and combinatorial Hodge Theory, and discuss several intermediate problems along the way. The main idea is based on a connection tocommutative algebra via the partition complex, an interpretation of local cohomology that allows for a tr",{"id":1085,"funder":7,"programme":8,"title":1086,"piName":14,"institution":1087,"country":47,"year":13,"amount":1088,"abstract":1089},"cordis-european-research-council-award-101045026","Dissecting a stepwise principle of cellular diversification to instruct regeneration in the enteric nervous system","KAROLINSKA INSTITUTET","€1,999,981","The enteric nervous system (ENS) contains a large range of neural subtypes that collectively controls essential gut functions independently of the central nervous system (CNS). Although the ENS is capable of forming new neurons following injury or inflammation, it fails to regenerate completely. My lab recently established a molecular classification of enteric neurons and discovered that they diversify through a conceptually new principle during development. Only two neuronal identities form dur",{"id":1091,"funder":7,"programme":8,"title":1092,"piName":14,"institution":1093,"country":98,"year":13,"amount":264,"abstract":1094},"cordis-european-research-council-award-101045466","Biological fabrication of cotton fibers with tailored properties","UNIVERSIDADE NOVA DE LISBOA","Naturally produced fibers have always played central roles in shaping human civilizations. Current hazardous chemical-based manufacturing processes and consumers' preferences for cotton products are putting much strain on the future of cottons global economy. Thus, it is urgent to seek future sustainable alternatives. What alternatives and tools are available? Which new avenues are waiting to be explored toward this end? Harnessing biological systems is one of humanitys ultimate frontiers. Yet, ",{"id":1096,"funder":7,"programme":8,"title":1097,"piName":14,"institution":608,"country":47,"year":13,"amount":1098,"abstract":1099},"cordis-european-research-council-award-101044220","The evolution of neural circuits for navigational decisions - from synapses to behavior","€1,999,119","Of the 1.2 million animal species described on Earth, more than 80% are insects. As for mammals, each insect is equipped with a brain that has evolved to optimally control the species’ behavior in the context of its environment. In more than 450 million years of evolution the neural circuits guiding behavioral decisions have diverged from an ancestral version to enable insects to conquer every terrestrial habitat on the planet and to equip many species with behavioral strategies that rival even ",{"id":1101,"funder":7,"programme":8,"title":1102,"piName":14,"institution":1103,"country":40,"year":13,"amount":1104,"abstract":1105},"cordis-european-research-council-award-101044664","New Horizons in Glass Structure Prediction and Mechanics","AALBORG UNIVERSITET","€1,996,935","Oxide glasses are one of the most important material families owing to their unique features, such as transparency, tunable properties, and formability. Emerging solutions to major global challenges related to energy, health, and electronics require new scientific breakthroughs in glass chemistry, mechanics, and processing. The realization of these goals is severely restricted by the main drawback of glass, namely high brittleness. Furthermore, new glass compositions are today developed through ",{"id":1107,"funder":7,"programme":8,"title":1108,"piName":14,"institution":1109,"country":1009,"year":13,"amount":1110,"abstract":1111},"cordis-european-research-council-award-101045180","LEGACIES : Understanding how historical states have shaped modern institutions and dissent","NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU","€1,977,464","While today’s political map divides the globe into about 200 sovereign states, there were hundreds more in the 18th and 19th centuries. Although most of these “historical states” no longer appear on modern maps, they have left behind institutions, symbols, and elite networks. What are the legacies of these “historical states”? We propose a new theoretical framework to unpack the impacts of historical states on patterns of conflict and democracy in the modern world and a powerful new method capab",{"id":1113,"funder":7,"programme":8,"title":1114,"piName":14,"institution":1115,"country":307,"year":13,"amount":14,"abstract":1116},"cordis-european-research-council-award-101042188","Solving the Bz problem in heliospheric weather forecasting","GEOSPHERE AUSTRIA - BUNDESANSTALT FUR GEOLOGIE, GEOPHYSIK, KLIMATOLOGIE UND METEOROLOGIE","A major unsolved problem in space weather involves predicting the solar wind at the Sun-Earth L1 point, specifically its speed and the north-south (Bz) magnetic field component. Knowledge of the future solar wind time evolution would allow us to drive any models for magnetospheric processes,  such as the aurora, the radiation belts, the ionosphere or the currents induced in power lines with much higher reliability and forecast lead time than currently possible. Our modern society increasingly de",{"id":1118,"funder":7,"programme":8,"title":1119,"piName":14,"institution":657,"country":40,"year":13,"amount":1120,"abstract":1121},"cordis-european-research-council-award-101043416","Altitude-like hypoxia cognition training to target brain erythropoietin as a novel mechanism of long-lasting enhancement of neuroplasticity and cognitive functions","€1,999,944","Cognitive decline is an urgent strategic treatment target to improve the lives of people with neuropsychiatric disorders and reduce associated societal costs but treatments with robust and long-lasting efficacy are essentially lacking. Neuroplasticity is pivotal for cognitive functions and its disruption is involved in cognitive decline. However, the mechanisms underlying long-lasting neuroplasticity are unknown, which impedes the discovery of effective treatments. To address this challenge, I h",{"id":1123,"funder":7,"programme":8,"title":1124,"piName":14,"institution":1125,"country":1126,"year":13,"amount":1127,"abstract":1128},"cordis-european-research-council-award-101044468","Bioinspired living skin for architecture","UNIVERZA NA PRIMORSKEM UNIVERSITA DEL LITORALE","SI","€1,999,000","Biofilms, an assemblage of surface-associated microbial cells that is enclosed in an extracellular polymeric substance matrix, are recognised as one of the most stable biological systems on earth. The beneficial use of biofilms for protection is nearly unexplored since up-to-date research is focused on the prevention of its formation. In the ARCHI-SKIN project, we will explore the design principles underlying fungal biofilm to bridge the knowledge gap on the chemistry-structure-properties of the",{"id":1130,"funder":7,"programme":8,"title":1131,"piName":14,"institution":657,"country":40,"year":13,"amount":1132,"abstract":1133},"cordis-european-research-council-award-101043468","Ritual Action: Making Deterrence Matter in International Security and Memory Politics","€1,949,291","Deterrence is the strategy of dissuading an opponent from taking an unwanted action for its prospective costs would outweigh the anticipated benefits either by the threat of effective defence or that of retaliation. The role of ritual in making deterrence effective, affectively charged and credible in the eyes of its practitioners has remained below the radar of the existing research. RITUAL DETERRENCE is the first project to pursue a ritual-centred investigation of deterrence in order to advanc",{"id":1135,"funder":7,"programme":8,"title":1136,"piName":14,"institution":1137,"country":741,"year":13,"amount":1138,"abstract":1139},"cordis-european-research-council-award-101044421","Using Human Rights to Change Abortion Law: Involvement Patterns and Argumentative Architectures in the Global Figuration of Human Rights","UNIWERSYTET WARSZAWSKI","€1,998,869","Abortion laws are the crux of human rights diversity today. Abortion laws evidence best how differently human rights meanings are construed in various local settings. However, we know very little about how this diversity is generated in practice. This project will scrutinize the communication processes that use human rights as arguments to change abortion laws. We will contrast abortion debates from the last ten years in pairs of countries that represent three regional human rights systems: Moza",200,{"programme":8,"total":1142,"withPiName":1143,"firstYear":1144,"lastYear":1145,"countryCount":1146,"perYear":1147,"topInstitutions":1187,"topCountries":1255},4499,349,2014,2027,45,[1148,1150,1153,1156,1159,1162,1165,1168,1171,1173,1176,1179,1182,1185],{"year":1144,"count":1149},303,{"year":1151,"count":1152},2015,335,{"year":1154,"count":1155},2016,322,{"year":1157,"count":1158},2017,327,{"year":1160,"count":1161},2018,403,{"year":1163,"count":1164},2019,300,{"year":1166,"count":1167},2020,277,{"year":1169,"count":1170},2021,321,{"year":13,"count":1172},364,{"year":1174,"count":1175},2023,359,{"year":1177,"count":1178},2024,366,{"year":1180,"count":1181},2025,375,{"year":1183,"count":1184},2026,416,{"year":1145,"count":1186},31,[1188,1191,1193,1196,1199,1202,1205,1207,1209,1212,1214,1217,1220,1222,1224,1227,1230,1233,1236,1239,1241,1244,1247,1250,1253],{"name":1189,"count":1190},"Centre National de la Recherche Scientifique CNRS",229,{"name":172,"count":1192},89,{"name":1194,"count":1195},"Weizmann Institute of Science",78,{"name":1197,"count":1198},"University of Cambridge",77,{"name":1200,"count":1201},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",63,{"name":1203,"count":1204},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",55,{"name":1206,"count":1204},"Institut National de la Sante Et de la Recherche Medicale",{"name":1208,"count":1204},"Kobenhavns Universitet",{"name":1210,"count":1211},"Universiteit Utrecht",51,{"name":1213,"count":1211},"University College London",{"name":1215,"count":1216},"Tel Aviv University",49,{"name":1218,"count":1219},"The Hebrew University of Jerusalem",43,{"name":1221,"count":1219},"Universiteit Gent",{"name":1223,"count":1219},"Universiteit van Amsterdam",{"name":1225,"count":1226},"Ludwig-Maximilians-Universitaet Muenchen",42,{"name":1228,"count":1229},"Technische Universitaet Muenchen",41,{"name":1231,"count":1232},"Eidgenoessische Technische Hochschule Zuerich",40,{"name":1234,"count":1235},"Universitat Wien",39,{"name":1237,"count":1238},"Helsingin Yliopisto",38,{"name":1240,"count":1238},"Technische Universiteit Delft",{"name":1242,"count":1243},"Katholieke Universiteit Leuven",37,{"name":1245,"count":1246},"Universitetet I Oslo",36,{"name":1248,"count":1249},"École Polytechnique Fédérale de Lausanne",34,{"name":1251,"count":1252},"The University of Edinburgh",32,{"name":1254,"count":1186},"Lunds Universitet",[1256,1258,1261,1263,1265,1267,1269,1271,1272,1274,1276,1278,1280,1282,1284,1286,1288,1290,1292,1294,1296,1299,1301,1303,1305],{"name":73,"count":1257},810,{"name":1259,"count":1260},"UK",559,{"name":21,"count":1262},490,{"name":66,"count":1264},428,{"name":33,"count":1266},315,{"name":12,"count":1268},267,{"name":235,"count":1270},219,{"name":574,"count":1140},{"name":47,"count":1273},170,{"name":210,"count":1275},166,{"name":307,"count":1277},146,{"name":40,"count":1279},127,{"name":190,"count":1281},94,{"name":1009,"count":1283},85,{"name":118,"count":1285},82,{"name":98,"count":1287},68,{"name":173,"count":1289},47,{"name":1291,"count":1246},"CZ",{"name":203,"count":1293},24,{"name":734,"count":1295},22,{"name":1297,"count":1298},"US",21,{"name":741,"count":1300},20,{"name":930,"count":1302},14,{"name":105,"count":1304},13,{"name":325,"count":1306},8]