[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-consolidator-grant-2023":3,"awarded-stats-erc-consolidator-grant":1119},{"awarded":4,"total":1118},[5,16,23,30,37,44,49,55,60,66,72,78,85,92,98,104,110,116,122,129,135,142,149,155,161,168,174,180,186,192,197,203,210,215,221,228,233,238,244,251,257,263,269,275,280,285,291,297,303,309,314,320,326,332,338,344,349,355,361,367,372,378,383,388,392,399,405,411,416,421,426,431,437,443,449,454,460,464,469,475,480,486,492,497,503,509,515,519,524,531,537,543,548,553,559,565,571,577,583,588,593,599,604,610,615,619,623,629,634,639,645,650,654,659,663,667,673,678,683,688,693,699,704,710,715,720,726,731,735,740,746,752,757,763,770,776,781,787,791,796,801,807,813,819,824,830,836,841,847,852,857,862,867,873,879,883,888,893,898,904,910,915,920,926,930,935,941,946,952,958,962,968,974,980,985,990,996,1001,1006,1012,1018,1022,1027,1031,1036,1040,1046,1050,1055,1061,1066,1071,1077,1082,1087,1092,1097,1104,1109,1114],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-101043851","European Research Council","ERC Consolidator Grant","Large-scale multipartite entanglement on a quantum metrology network",null,"GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER","DE",2023,"€2,694,623","Hundreds and thousands of fireflies synchronize their dazzling light in summer nights – one of nature’s most beautiful demonstrations on the importance of synchronization and scalability in a network. So we ask the question, is it possible and even necessary to synchronize all components in a complex large-scale quantum network?This is not a question for the future. Rapid experimental progress in recent years has brought first rudimentary quantum networks within reach, highlighting the timelines",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":20,"year":13,"amount":21,"abstract":22},"cordis-european-research-council-award-101043548","Ecosystem recovery dynamics and their response to climate change and habitat fragmentation","ASOCIACION BC3 BASQUE CENTRE FOR CLIMATE CHANGE - KLIMA ALDAKETA IKERGAI","ES","€1,999,315","Global change degrades ecosystems worldwide. To mitigate its effects is the environmental challenge of our age, and restoration has emerged as the main strategy to stem the biodiversity crisis and repair damaged ecosystems. Despite substantial progress on the number of restoration studies and datasets, there is a fundamental gap in our understanding and prediction of the patterns and mechanisms underlying ecological restoration and how they are altered by global change.The goal of RECODYN is to ",{"id":24,"funder":7,"programme":8,"title":25,"piName":10,"institution":26,"country":27,"year":13,"amount":28,"abstract":29},"cordis-european-research-council-award-101043536","When Parental Support Backfires on Adolescents","ERASMUS UNIVERSITEIT ROTTERDAM","NL","€2,000,000","One-third of adolescents (12-18) experience emotional problems, such as anxiety and depression. This leads to enormous personal impact which often continues a lifetime. Support from parents is a protective factor that can increase the well-being of adolescents and reduce depression and anxiety. However, defying this currently held view, concerns are growing that support backfires in some families. THE PARENTAL SUPPORT PARADOX. No matter how well-intended and well-received in the short run, over-",{"id":31,"funder":7,"programme":8,"title":32,"piName":10,"institution":33,"country":34,"year":13,"amount":35,"abstract":36},"cordis-european-research-council-award-101043985","Paving the way for High-throughput Organoid ENgineering using Integrated acoustiX","UPPSALA UNIVERSITET","SE","€2,832,500","The aim of PHOENIX is to use my expertise in microsystems engineering to close critical technology gaps in organoid generation. Cerebral organoids are 3D self-assembled structures derived from human induced pluripotent stem cells, replicating both structure and function of the human foetal brain. Organoids have the potential to replace existing 2D cell cultures and animal models, but this has not yet been realised due to rudimentary preparation methods.In PHOENIX, three important technology gaps",{"id":38,"funder":7,"programme":8,"title":39,"piName":10,"institution":40,"country":41,"year":13,"amount":42,"abstract":43},"cordis-european-research-council-award-101045733","PROcessing MEtaphors: Neurochronometry, Acquisition and DEcay","ISTITUTO UNIVERSITARIO DI STUDI SUPERIORI ( I.U.S.S.) DI PAVIA","IT","€1,854,188","As the master figure of speech, metaphor is a powerful communicative tool that might nevertheless come with costs for our processing system. Research in different fields has highlighted that a full-fledged metaphor comprehension capacity is a late achievement in development, it may decay as a consequence of several pathological conditions, and it evokes distinctive electrical activity in our brain compared to literal equivalents. However, we still miss a comprehensive framework able to account f",{"id":45,"funder":7,"programme":8,"title":46,"piName":10,"institution":47,"country":12,"year":13,"amount":28,"abstract":48},"cordis-european-research-council-award-101043364","Mechanisms and consequences of cell state transitions during heart regeneration","MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)","Organs consist of cells with a large diversity of specialized roles. A fundamental question is how these cells mount a coordinated response in space and time to maintain or restore organ function after perturbation. Recent progress in single-cell genomics has generated the opportunity to understand this process on a system-wide scale. We will use the adult zebrafish heart as a powerful model system to dissect how regeneration after injury is orchestrated by the activation response of multiple di",{"id":50,"funder":7,"programme":8,"title":51,"piName":10,"institution":52,"country":12,"year":13,"amount":53,"abstract":54},"cordis-european-research-council-award-101045003","Adaptive functions of visual systems","JOHANNES GUTENBERG-UNIVERSITAT MAINZ","€1,999,613","The processing of visual information allows humans, animals, and computer-vision based machines to navigate the world. All visual systems face common challenges when the world rapidly changes. Such changes are often generated by an animal’s own movement. Self-motion for example causes fast changes in illumination and generates global motion patterns on the eye, due to the movement of the world relative to the observer. Diverse visual systems face these common challenges but must also deal with i",{"id":56,"funder":7,"programme":8,"title":57,"piName":10,"institution":58,"country":12,"year":13,"amount":10,"abstract":59},"cordis-european-research-council-award-101045136","Cyanobacterial glycolipids as tracers of continental climate change","RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN","Global surface temperatures are increasing in a manner unprecedented in modern Earth history. The extent of future warming on regional to global scales is difficult to predict but crucial for developing climate-resilient pathways and strategies for adaptation and sustainability. The study of ancient climates allows a mechanistic exploration of the Earth system and the opportunity to quantitatively and qualitatively evaluate and improve new generations of climate models. Particularly on the conti",{"id":61,"funder":7,"programme":8,"title":62,"piName":10,"institution":63,"country":12,"year":13,"amount":64,"abstract":65},"cordis-european-research-council-award-101044932","Network epistemology in practice","TECHNISCHE UNIVERSITAT BERLIN","€1,992,181","The present project will contribute to research in the history and philosophy of science through extensive use of state-of-the-art tools from the digital humanities. The project will focus on an investigation of recent research practice in particle physics at the European Center for Nuclear Research (CERN) in order to gain a better understanding of how knowledge is generated and validated in very large scientific collaborations. The main working hypothesis of the project is that collective resea",{"id":67,"funder":7,"programme":8,"title":68,"piName":10,"institution":69,"country":12,"year":13,"amount":70,"abstract":71},"cordis-european-research-council-award-101044616","How EXPectation and ATtention shape visual information processing in the human brain","UNIVERSITATSKLINIKUM SCHLESWIG-HOLSTEIN","€1,999,815","Our behaviours and conscious experiences are profoundly shaped by what we see. Therefore, it is not surprising that unravelling the neural mechanisms of vision ranks among the top priorities of neuroscience. This poses the challenge of unravelling how our brain creates seamless and comprehensible visual experiences from the dizzying onslaught of visual information bombarding our retinae. Previous research suggests that expectation and attention play a central role in coordinating this informatio",{"id":73,"funder":7,"programme":8,"title":74,"piName":10,"institution":75,"country":27,"year":13,"amount":76,"abstract":77},"cordis-european-research-council-award-101044356","Causal Pattern Analysis of Networked Economic Sovereignty","TILBURG UNIVERSITY- UNIVERSITEIT VAN TILBURG","€1,929,204","The legal concept of sovereignty does not capture foreign trade relations, networks or economic clout. This shortcoming has resulted from a historical reduction of its meaning since the 1600s. This project will analyze legal concepts of sovereignty that developed before that time, within six networked cities of commerce (Bruges, Southampton, Rouen, Lübeck, Toulouse and Florence). In the period of 1400-1620 cities were interconnected through trade routes, correspondence and diplomacy. Legal conce",{"id":79,"funder":7,"programme":8,"title":80,"piName":10,"institution":81,"country":82,"year":13,"amount":83,"abstract":84},"cordis-european-research-council-award-101045227","Subject or Object? SINo-American competition and European sTRAtegic autonomy","VRIJE UNIVERSITEIT BRUSSEL","BE","€1,726,250","The intensifying great power competition between the United States and China has arguably become the structuring vector in international politics. This project examines to what extent the European Union (EU) is able to autonomously make decisions regarding its relations with the United States and China. The key innovation is to present a comprehensive theory to explain to what extent and under what circumstances external or internal actors have the upper hand in informing European policy choices",{"id":86,"funder":7,"programme":8,"title":87,"piName":10,"institution":88,"country":89,"year":13,"amount":90,"abstract":91},"cordis-european-research-council-award-101044797","Efficient and functional optical frequency conversion in 3D Nonlinear Optical Artificial Materials","TEL AVIV UNIVERSITY","IL","€3,000,000","Optical frequency conversion in bulk nonlinear crystals is used for generation of coherent light over the entire optical regime from extreme ultra-violet up to THz waves. This remarkable ability is at the core of a plethora of important technological and scientific applications. However, bulk nonlinear crystals pose strong limitations on integration, miniaturization, and control over the nonlinear interactions, holding back the further progress of optical frequency conversion technologies. I pro",{"id":93,"funder":7,"programme":8,"title":94,"piName":10,"institution":95,"country":12,"year":13,"amount":96,"abstract":97},"cordis-european-research-council-award-101043504","Art Academies in China: Global Histories and Institutional Practices","FREIE UNIVERSITAET BERLIN","€1,955,208","Art academies played an essential role in shaping modern art in China. They were the sites where European methods of art education were introduced; where the social role of the modern artist was defined; where the importance of traditional art forms and training methods was negotiated; where art history as a modern field was established; and where political and ideological changes in artistic practices were first implemented. Today, art academies incorporate laboratories of innovation as well as",{"id":99,"funder":7,"programme":8,"title":100,"piName":10,"institution":101,"country":12,"year":13,"amount":102,"abstract":103},"cordis-european-research-council-award-101044657","Phase-resolved THz-Higgs Spectroscopy on Superconductors","TECHNISCHE UNIVERSITAET DRESDEN","€2,292,750","T-Higgs develops “Higgs Spectroscopy” as novel tool to probe the order parameter in superconductors. It will allow unprecedented insights into the structure and dynamics of the condensate and shine new light onto the physics of unconventional superconductors. In particular high temperature superconductivity calls for new probes to reveal its pairing mechanism. T-Higgs can also be applied to intriguing phenomena like light- induced superconductivity, superconductivity in “twisttronics” or under e",{"id":105,"funder":7,"programme":8,"title":106,"piName":10,"institution":107,"country":108,"year":13,"amount":28,"abstract":109},"cordis-european-research-council-award-101044495","Mechanism of vertebrate sperm-egg recognition and fusion","FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH","AT","The life of every sexually reproducing being can be traced back to a singular event: the fusion of sperm and egg. Gamete fusion is perhaps the most critical step in the process of fertilization. However, the mechanisms underlying vertebrate sperm-egg fusion and the events that precede it (sperm-egg recognition) are largely unknown. Uncovering the molecular machinery and biophysical mechanisms mediating sperm-egg recognition and membrane fusion in vertebrates is therefore one of the biggest chall",{"id":111,"funder":7,"programme":8,"title":112,"piName":10,"institution":113,"country":12,"year":13,"amount":114,"abstract":115},"cordis-european-research-council-award-101044725","Off the Road: The Environmental Aesthetics of Early Automobility","UNIVERSITAT KONSTANZ","€1,978,350","In times of climate crisis, there is wide agreement that we need a more environmental approach to automobility. “Off the Road” addresses this challenge by highlighting a largely forgotten fact: that automobility was a thoroughly environmental experience before the current system of closed cars on concrete roads emerged. This environmental automobility was particularly widespread in the United States, where much driving occurred in off-road conditions well into the 1920s. Motorists navigated thro",{"id":117,"funder":7,"programme":8,"title":118,"piName":10,"institution":119,"country":89,"year":13,"amount":120,"abstract":121},"cordis-european-research-council-award-101043243","Foundations of Timed-Release Cryptography","THE HEBREW UNIVERSITY OF JERUSALEM","€1,897,685","Cryptography has repeatedly revolutionized modern technology via its easy-or-infeasible design paradigm, classifying computations as either easy or infeasible. Nowadays, however, this foundational paradigm is insufficient for a host of rapidly evolving applications, and a fine-grained accounting of sequential timing guarantees is urgently needed. This has recently led to substantial interest in the classic yet insufficiently-explored vision of timed-release cryptography, enabling cryptographic s",{"id":123,"funder":7,"programme":8,"title":124,"piName":10,"institution":125,"country":126,"year":13,"amount":127,"abstract":128},"cordis-european-research-council-award-101045072","3D Printed, Bioinspired, Soft-Matter Electronics based on Liquid Metal Composites: Eco-Friendly, Resilient, Recyclable, and Repairable","UNIVERSIDADE DE COIMBRA","PT","€2,781,215","Liquid3D proposes bioinspired electronics and machines that are soft, resilient, self-healing, shape-morphing, and fully recyclable. Functional sensing\u002Facting\u002Fprocessing\u002Fenergy cells will be 3D printed using a series of game changer Liquid Metal based composites.  As a result, we will print futuristic soft electronics that sense and interact with humans or the environment. This provides an excellent design freedom to scientists for manufacturing complex “living” electronics, while guaranteeing t",{"id":130,"funder":7,"programme":8,"title":131,"piName":10,"institution":132,"country":41,"year":13,"amount":133,"abstract":134},"cordis-european-research-council-award-101044015","Political Elites and Regime Change in the Middle East and North Africa: Accommodation or Exclusion?","SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA","€1,915,601","Whether political elites accommodate or exclude their rivals during regime crises can be a matter of life and death. Following the 2011 uprisings in the Middle East and North Africa (MENA), elite compromise sustained a democratic transition in Tunisia, while elite conflict triggered a coup in Egypt. Tunisia has since seen three democratic elections, while thousands of Egyptians were jailed or killed by the new military regime. Why do elites in some cases pursue accommodation while they push for ",{"id":136,"funder":7,"programme":8,"title":137,"piName":10,"institution":138,"country":139,"year":13,"amount":140,"abstract":141},"cordis-european-research-council-award-101045223","Multimodal Sensory-Motorized Material Systems","TAMPEREEN KORKEAKOULUSAATIO SR","FI","€1,998,760","WHAT: MULTIMODAL will develop sensory-motorized material systems that perceive several coupled environmental stimuli and respond to a combination of these via controlled motor functions, shape-change or locomotion. The sensory-motorized materials will be “trained” to strengthen upon repetitive action, they can “heal” upon injury, and mechanically adapt to different environments. They will be utilized in the design of soft robots with autonomous and interactive functions.HOW: We will utilize shap",{"id":143,"funder":7,"programme":8,"title":144,"piName":10,"institution":145,"country":146,"year":13,"amount":147,"abstract":148},"cordis-european-research-council-award-101043452","Phage infection of bacterial biofilm","Masarykova univerzita","CZ","€1,992,976","In 2017, the World Health Organization declared Staphylococcus aureus to be an antibiotic-resistant pathogen for which new therapeutics are urgently needed. Upon infection, S. aureus forms biofilms that can only be treated by the long-term application of several antibiotics in high doses or the surgical removal of the infected tissues. An alternative approach, phage therapy, has not been approved for clinical use, because the effects of phage infection on a biofilm are not sufficiently character",{"id":150,"funder":7,"programme":8,"title":151,"piName":10,"institution":152,"country":146,"year":13,"amount":153,"abstract":154},"cordis-european-research-council-award-101044740","Biodiversity dynamics across a continuum of space, time, and their scales","CESKA ZEMEDELSKA UNIVERZITA V PRAZE","€1,999,363","We face an unprecedented threat from global alteration of nature and biodiversity, but we still lack rigorous estimates of how fast, where, and at which scales biodiversity changes. Studies report fragmented and seemingly contradictory results, suffer from mismatches in biodiversity metrics, mismatches in temporal and spatial grains, and are constrained by huge data gaps. Moreover, local loss and gain of biodiversity is decoupled from changes in countries or continents, with opposing directions ",{"id":156,"funder":7,"programme":8,"title":157,"piName":10,"institution":158,"country":12,"year":13,"amount":159,"abstract":160},"cordis-european-research-council-award-101043835","Molecular and Genome Evolution of Prokaryotic Plasmids","CHRISTIAN-ALBRECHTS-UNIVERSITAET  ZU KIEL","€2,112,500","Plasmids are autonomously replicating extra-chromosomal elements that play a major role in prokaryote ecology and evolution. The study of plasmid evolution has so far focused mostly on their biodiversity and effect on their host ecology and evolution. Nonetheless, the fundamentals of plasmid genome evolution remain to a large extent uncharted territory. Plasmids reside within a host cell that supplies their environmental, energetic and metabolic requirements. Consequently, natural selection oper",{"id":162,"funder":7,"programme":8,"title":163,"piName":10,"institution":164,"country":165,"year":13,"amount":166,"abstract":167},"cordis-european-research-council-award-101044319","A coherent approach to analysing heterogeneity in network data","FONDATION JEAN JACQUES LAFFONT,TOULOUSE SCIENCES ECONOMIQUES","FR","€966,000","The overarching goal of this project is to develop a coherent set of econometric methods to deal with unobserved heterogeneity in the analysis of social interactions between agents. Such heterogeneity is well recognized to be important. It is often of great interest to document the degree of heterogeneity, evaluate its impact, and uncover the existence and form of any complementarities that may exist between agents. With the growing availability of network data, questions of this kind are increa",{"id":169,"funder":7,"programme":8,"title":170,"piName":10,"institution":171,"country":41,"year":13,"amount":172,"abstract":173},"cordis-european-research-council-award-101044228","revolutionary tailored ARChitected Heterostructures obtained by solId state DEPosition","POLITECNICO DI MILANO","€1,998,000","Imagine having unlimited freedom in design and scalable fabrication of engineering components with an almost arbitrary selection of mixed composition, inner spatial arrangement and outer shape; this implies the ability to integrate multiple heterogeneity indexes to selectively adjust a variety of site-specific properties over several length-scales in one single component. To offer this treat, ArcHIDep challenges the traditional (composition-structure-process)-function correlations that currently",{"id":175,"funder":7,"programme":8,"title":176,"piName":10,"institution":177,"country":178,"year":13,"amount":28,"abstract":179},"cordis-european-research-council-award-101045646","Particle Resolving Fluid-Sediment Interaction","NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU","NO","Climate change leads to increased frequency and magnitude of flash flood events in rivers and of storm surges in coastal areas. Flash floods are associated with larger discharges and water levels, whereas storm surges are characterized by higher wave heights and water levels. These events have significant consequences for both rivers and coastlines triggering a morphodynamic response. Resulting erosion and soil mechanical failures can result in severe damage to civil infrastructure and buildings",{"id":181,"funder":7,"programme":8,"title":182,"piName":10,"institution":183,"country":12,"year":13,"amount":184,"abstract":185},"cordis-european-research-council-award-101048445","In Pursuit of 'Legality' and 'Justice': Minority Struggles in the Russian Empire and the Soviet Union","GEISTESWISSENSCHAFTLICHE ZENTREN BERLIN EV","€1,996,988","The Russian Empire and the Soviet Union are rarely associated with the rule of law. And yet, the notions of legality and justice greatly mattered in both: political and cultural elites invoked them as much as the wider citizenries. While existing literature has addressed legality and justice in studies of state policy and intellectual opposition to the two orders, there is little recognition of how instrumental they both were to ethnic and religious minorities. Whereas religion was one of the ke",{"id":187,"funder":7,"programme":8,"title":188,"piName":10,"institution":189,"country":20,"year":13,"amount":190,"abstract":191},"cordis-european-research-council-award-101043428","Bringing Nanospace to Life by Adapting Pore Environments to Chemical Complexity","UNIVERSITAT DE VALENCIA","€1,998,974","The conformational flexibility and biological function of proteins is dictated by the positioning of a few amino acids into specific arrangements linked by peptide bonds. We intend to implement this same principle of sequencing, essential to biology, to synthetic porous materials by encoding pore environments with atomic precision to control structural response and function. The road to this vision remains blocked by the lack of methodologies and understanding which is required to untap the valu",{"id":193,"funder":7,"programme":8,"title":194,"piName":10,"institution":195,"country":27,"year":13,"amount":28,"abstract":196},"cordis-european-research-council-award-101044794","Dynamics and heterogeneity of early viral infection","KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW","Viruses are simple replicative units built from two components: a nucleic acid and a small number of associated proteins. Upon entering a cell, viruses co-opt the hosts machineries to copy their genetic material, while shutting down the hosts antiviral immune response. The success of viral infection differs dramatically from cell to cell through poorly understood mechanisms, resulting in heterogenous propagation through tissues, and ultimately, heterogeneous disease progression.Although viruses ",{"id":198,"funder":7,"programme":8,"title":199,"piName":10,"institution":200,"country":126,"year":13,"amount":201,"abstract":202},"cordis-european-research-council-award-101043231","Animal ABidings: recoverIng from DisastErs in more-than-human communities","INSTITUTO DE CIENCIAS SOCIAIS","€1,999,970","What and how can we learn from animals about recovering from disasters? How can we hear them in their own terms, translate their stories, and include their perspectives, in human knowledge about disasters? This project explores the resilience of multispecies communities, and their capacities for healing and bouncing back from disasters, through the point of view of nonhuman animals. It departs from the current context of acute climate crisis, which sets the stage for Dantesque scenarios of impen",{"id":204,"funder":7,"programme":8,"title":205,"piName":10,"institution":206,"country":207,"year":13,"amount":208,"abstract":209},"cordis-european-research-council-award-101045094","Growing Machines Capable of Rapid Learning in Unknown Environments","IT-UNIVERSITETET I KOBENHAVN","DK","€1,994,225","Despite major advances in the field of artificial intelligence, especially in the field of neural networks, these systems still pale in comparison to even simple biological intelligence. Current machine learning systems take many trials to learn, lack common-sense, and often fail even if the environment only changes slightly. The enormous potential of autonomous machines remains unfulfilled and we still lack robots to fill our dishwashers or go on autonomous search-and-rescue missions. The grand",{"id":211,"funder":7,"programme":8,"title":212,"piName":10,"institution":113,"country":12,"year":13,"amount":213,"abstract":214},"cordis-european-research-council-award-101045788","Collective Dynamics of Sleep","€2,912,102","Sleep is a biological imperative for all animals: insufficient sleep can have detrimental effects on individuals’ health, cognition, social functioning and overall fitness. Even among gregarious species, sleep has largely been studied in lone individuals in laboratory settings, divorced from relevant socio-ecological context, limiting our ability to understand how social environments shape, and are shaped by, the sleep patterns of their members. My goal is to bring the study of sleep into the co",{"id":216,"funder":7,"programme":8,"title":217,"piName":10,"institution":218,"country":126,"year":13,"amount":219,"abstract":220},"cordis-european-research-council-award-101045172","Extreme Particle Acceleration in Shocks: from the laboratory to astrophysics","IST-ID ASSOCIACAO DO INSTITUTO SUPERIOR TECNICO PARA A INVESTIGACAO E O DESENVOLVIMENTO","€1,799,990","Astrophysical shocks are among the most powerful particle accelerators in the Universe. Generated by violent interactions of supersonic, and often relativistic, plasma flows with the ambient medium, shock waves involve a complex and highly nonlinear interplay between the dynamics of flows, magnetic fields, and accelerated particles through mechanisms not yet fully understood. What is the origin of cosmic rays?, What controls particle injection and the acceleration efficiency in collisionless sho",{"id":222,"funder":7,"programme":8,"title":223,"piName":10,"institution":224,"country":225,"year":13,"amount":226,"abstract":227},"cordis-european-research-council-award-101045152","Building Conceptual and Methodological Expertise for the Study of Gender, Agency and Authority in Islam","UNIVERSITY OF GALWAY","IE","€1,994,249","BILQIS emerges from a critical concern around Muslim women’s access to justice in Europe. BILQIS will be driven by methodological advances in Islamic feminism that the PI has been to the fore in delivering and will be primarily distinguished by its systematic and rigorous inquiries into questions of gender in relation to Islamic family laws (IFL) and IFL-related socio-religious and socio-legal power structures. The project will engage in a comparative study how Muslim women in Europe have naviga",{"id":229,"funder":7,"programme":8,"title":230,"piName":10,"institution":231,"country":12,"year":13,"amount":28,"abstract":232},"cordis-european-research-council-award-101042597","'Machinery Rooms' of the Mediterranean, 1800-present: Images and Visual Archives of Movement and Acceleration","HEINRICH-HEINE-UNIVERSITAET DUESSELDORF","The aim of MEDMACH is to write a new history of the Mediterranean after 1800 through images of movement: infrastructures and machineries of acceleration such as airports, train stations, motorway bridges, industrial ports, and engine-driven ships. These sites are often overlooked in overarching narratives of the region. The Mediterranean after 1800 typically appears either in decline or romanticized, therefore this ‘machinery room’ of modernity has never been at the center of attention. However,",{"id":234,"funder":7,"programme":8,"title":235,"piName":10,"institution":224,"country":225,"year":13,"amount":236,"abstract":237},"cordis-european-research-council-award-101045226","Disruptive Therapies for the long-term relief of Osteoarthritis Pain","€1,998,885","Osteoarthritis (OA) is the most common cause of chronic pain in older persons in Europe and is the leading cause of disability. The disease is a condition affecting the joint cartilage and subchondral bone and is frequently accompanied by pain, stiffness, and long-term disability.  Chronic pain is the most prominent symptom in most people with OA, and is the most important determinant of disability in patients with osteoarthritis.  Treatment guidelines for OA pain management uniformly recommends",{"id":239,"funder":7,"programme":8,"title":240,"piName":10,"institution":241,"country":20,"year":13,"amount":242,"abstract":243},"cordis-european-research-council-award-101045424","Food Circuits: Hidden Connections between Migrants and Societies","UNIVERSITAT DE BARCELONA","€2,017,409","Most fruit and vegetables required and enjoyed by European and North American societies would not be possible without the planting, harvesting and transporting performed by migrant labourers. Yet, the contribution of migrants to crucial food systems is generally hidden in the experience of buying and consuming food. In this project, I take asparagus from Germany, oranges from Spain and strawberries from California as the vantage points from which to see connections between migrants and societies",{"id":245,"funder":7,"programme":8,"title":246,"piName":10,"institution":247,"country":248,"year":13,"amount":249,"abstract":250},"cordis-european-research-council-award-101043356","Reading provenance from ubiquitous quartz:  understanding the changes occurring in its lattice defects in its journey in time and space by physical methods","UNIVERSITATEA BABES BOLYAI","RO","€2,657,500","Quantitative provenance analysis studies are instrumental in understanding the tectonic and climatic processes that are shaping Earth`s landscape. Although the most abundant mineral in the sedimentary system is quartz, almost all studies in provenance analysis investigate accessory minerals. Quartz crystals contain a vast number of point defects, intrinsic or due to impurities. Although our understanding on the formation and dynamics of these defects is far from complete, a few of these defects ",{"id":252,"funder":7,"programme":8,"title":253,"piName":10,"institution":254,"country":34,"year":13,"amount":255,"abstract":256},"cordis-european-research-council-award-101044878","Towards increased biosafety for non-target insects - Damage-activated proteolysis to selectively enhance toxicity of pesticides","SVERIGES LANTBRUKSUNIVERSITET","€1,999,720","Insects numbers and diversity have rapidly declined in the EU and worldwide. Pesticides, and particularly the toxicity of insecticides to non-target insects (e.g. bees), are one of the major drivers of insect declines. Apart from destabilizing natural ecosystems, pollinator disappearance directly threatens food security.To help combat insect decline, I propose an innovative approach for the damage-activation of pro-pesticides (DAPP) by plant proteases that are activated in the gut of feeding cat",{"id":258,"funder":7,"programme":8,"title":259,"piName":10,"institution":260,"country":89,"year":13,"amount":261,"abstract":262},"cordis-european-research-council-award-101125981","Biophysical Models of Bacterial Growth","WEIZMANN INSTITUTE OF SCIENCE","€1,708,613","Biology operates in a dynamic, changing environment, with fluctuations occurring over many time and length scales. Microorganisms are capable of duplicating themselves accurately over a short time in this noisy environment. This self-replication, known as the “cell cycle”, must be tightly regulated in order for replication to be efficient. Key processes such as growth (both of volume and biomass), division and DNA replication must be coordinated. What biophysical cues are measured by the cell an",{"id":264,"funder":7,"programme":8,"title":265,"piName":10,"institution":266,"country":89,"year":13,"amount":267,"abstract":268},"cordis-european-research-council-award-101044195","The 'Vanishing Third Party': Access to Justice, Procedural Justice and Substantive Justice in the Age of Dispute Resolution Automation","UNIVERSITY OF HAIFA","€1,971,671","Courts without judges? Informal processes without mediators? We are on the verge of a dramatic paradigm shift in our justice system from human to algorithmic dispute resolution. While most of us perceive the delivery of justice as a human task, courts and informal arenas worldwide are increasingly relying on online processes that employ algorithms in lieu of judges and mediators. Also, artificial intelligence is more commonly used to support and predict judicial outcomes. Together, these develop",{"id":270,"funder":7,"programme":8,"title":271,"piName":10,"institution":272,"country":165,"year":13,"amount":273,"abstract":274},"cordis-european-research-council-award-101044362","Brain mechanisms of conscious processing, from correlates to signatures","UNIVERSITE PARIS CITE","€1,918,515","When we are awake, part of the information processed by our brain becomes conscious, so that we can acknowledge and report it. Despite important advances, there is no consensus on what brain mechanisms underlie this phenomenon. According to some models, we become conscious of a stimulus when information gets integrated across different sensory areas; for other, conscious processing only arises when sensory representations are made available to the executive system. With this project I explore a ",{"id":276,"funder":7,"programme":8,"title":277,"piName":10,"institution":241,"country":20,"year":13,"amount":278,"abstract":279},"cordis-european-research-council-award-101044779","Inclusive Artificial Intelligence for Accessible Medical Imaging Across Resource-Limited Settings","€2,206,963","Artificial intelligence (AI) is widely regarded as one of the most promising and disruptive technologies for future healthcare. As AI algorithms such as deep neural networks are suited for the processing of large and complex datasets, radiology is the medical speciality that has seen some of the most important applications of AI in the recent years. However, despite these advances, a major limitation of current AI developments in medical imaging is that they have overwhelmingly, and almost entir",{"id":281,"funder":7,"programme":8,"title":282,"piName":10,"institution":33,"country":34,"year":13,"amount":283,"abstract":284},"cordis-european-research-council-award-101044505","Testing the paradigm of a single plastid origin in eukaryotes","€1,997,978","Photosynthesis was acquired by eukaryotes through endosymbiosis with cyanobacteria, which resulted in new cellular organelles: the plastids. From the origin of plastids evolved the first eukaryotic algae, giving rise to land plants but also triggering the evolution of most photosynthetic eukaryotes by subsequent endosymbioses between these first algae and other eukaryotes. Thus, the origin of plastids profoundly changed the course of eukaryotic life by being the launching point that shaped the b",{"id":286,"funder":7,"programme":8,"title":287,"piName":10,"institution":288,"country":27,"year":13,"amount":289,"abstract":290},"cordis-european-research-council-award-101043543","Politicians under Radical Uncertainty:  How Uncertain Phenomena Influence Political Elites' Behavior","UNIVERSITEIT UTRECHT","€1,995,424","Political elites-political representatives who can take binding decisions, e.g. ministers, parliamentarians, local politicians-face numerous radically uncertain phenomena, from Covid-19 to the long-term effects of Brexit. Radical uncertainty is characterized by manifold unknowns, ambiguity and vagueness, and it differs fundamentally from resolvable uncertainty, those situations in which it is possible to assign probabilities to outcomes, like the electoral consequences of welfare retrenchment. R",{"id":292,"funder":7,"programme":8,"title":293,"piName":10,"institution":294,"country":225,"year":13,"amount":295,"abstract":296},"cordis-european-research-council-award-101045738","Flexible Work, Rigid Politics: The Nexus Between Labour Precariousness and Authoritarian Politics in The Global South (Brazil, India, Philippines)","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","€1,998,711","This project will investigate the nexus between labour precariousness and authoritarian politics in Brazil, India, and the Philippines (BIP). At the beginning of the 2000s, emergent economies were promising global democratic powers. Yet, democratic consolidation faces significant challenges as BIP nations elect populist authoritarian politicians. The understanding of such a process remains fragmented or limited to a global North repertoire. This project proposes a framework that examines emergin",{"id":298,"funder":7,"programme":8,"title":299,"piName":10,"institution":300,"country":12,"year":13,"amount":301,"abstract":302},"cordis-european-research-council-award-101043474","Why are the Big Two of Agency and Communion so Fundamental to Human Psychology? An Agency-Communion Theory (ACT) of Social Learning and Cultural Activity and Its Novel Account of Social Influence","UNIVERSITAET MANNHEIM","€1,999,818","The Big Two of agency (influence, resourcefulness, authority) and communion (benevolence, prosociality, honesty) are fundamental to human social cognition, the self-concept, and personality. The Big Two must have a tremendously important function for humans, otherwise they were not that fundamental to human psychology. Yet, what is this function? State-of-the-art answers explain the function of the Big Two either in social cognition or in the self-concept or in personality and those answers cont",{"id":304,"funder":7,"programme":8,"title":305,"piName":10,"institution":306,"country":20,"year":13,"amount":307,"abstract":308},"cordis-european-research-council-award-101043738","Drivers of Demographic Dynamics","UNIVERSITAT AUTONOMA DE BARCELONA","€2,765,537","This project aims to reconstruct the human demography of SW Amazonia during the Holocene and to reveal the role of environmental and cultural changes in shaping it. Despite decades of research, the relative importance of environmental vs cultural factors in determining prehistoric population growth is still one of archaeology’s greatest scientific challenges. Reaching an agreement about the drivers of demographic dynamics is very difficult because of the fragmentary, incomplete and biased nature",{"id":310,"funder":7,"programme":8,"title":311,"piName":10,"institution":306,"country":20,"year":13,"amount":312,"abstract":313},"cordis-european-research-council-award-101043986","Testing for the universal mind using probabilistic inference","€2,051,921","Is the human mind an evolutionary one-off? Or does it reflect a ‘universal mind’ in which similar cognitive mechanisms repeatedly evolve via convergent evolution? Avian cognition offers a powerful model system for answering this fundamental question about the nature of our mind, because birds last shared a common ancestor with humans 312 million years ago and have evolved brains with a very different structure. However, to unlock the potential of this model system we need to robustly test whethe",{"id":315,"funder":7,"programme":8,"title":316,"piName":10,"institution":317,"country":12,"year":13,"amount":318,"abstract":319},"cordis-european-research-council-award-101043686","Loop Corrections from the Theory of Motives","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","€1,999,878","The interactions between the elementary particles are encoded into a set of mathematical quantities called scattering amplitudes. Consequently, they are key to making predictions for physical observables that match the precision achieved by current and future high-energy experiments. Due to our ignore of the mathematics involved, computing loop quantum corrections to scattering amplitudes is still a major challenge today, and calls for innovative and groundbreaking new techniques.Over the last d",{"id":321,"funder":7,"programme":8,"title":322,"piName":10,"institution":323,"country":12,"year":13,"amount":324,"abstract":325},"cordis-european-research-council-award-101044247","Forecasting climate surprises on longer timescales","ALFRED-WEGENER-INSTITUT HELMHOLTZ-ZENTRUM FUR POLAR- UND MEERESFORSCHUNG","€1,976,300","The Greenland and Antarctic ice sheets (GrIS and AIS, respectively) and the Atlantic Meridional Overturning Circulation (AMOC) are prominent examples of tipping elements in the Earth system that have the potential to respond nonlinearly to small changes in forcing. Tipping elements can thus give rise to climate surprises, i.e., low-probability, high-impact events that may be triggered earlier than expected. Simulating such climate surprises and their impacts, on the relevant multi-centennial tim",{"id":327,"funder":7,"programme":8,"title":328,"piName":10,"institution":329,"country":27,"year":13,"amount":330,"abstract":331},"cordis-european-research-council-award-101044831","Translational optoelectronic control of cardiac rhythm in atrial fibrillation","ACADEMISCH ZIEKENHUIS LEIDEN","€1,999,999","It’s my conviction that, one day, we will enable the human heart to terminate its own rhythm disturbances and thereby restore its normal rhythm at any place and time. Such acute restoration of cardiac rhythm would not be based on traumatizing electric shocks, but on generation of bioelectricity by the affected heart itself. In order to explore this paradigm-changing approach for ambulatory shock-free control of cardiac rhythm, I will integrate the unique advances of genetic engineering, computer",{"id":333,"funder":7,"programme":8,"title":334,"piName":10,"institution":335,"country":178,"year":13,"amount":336,"abstract":337},"cordis-european-research-council-award-101043382","From small-scale cooperative herding groups to nomadic empires – a cross-cultural approach","STIFTELSEN NORSK INSTITUTT FOR KULTURMINNEFORSKNING","€1,998,859","The main question of this research project is: can political complexity evolve from small-scale cooperative groups? The predominant view of nomadic empires – that they are caused by contact with agricultural neighbours – cannot explain how pastoralists transitioned from small, kin-based cooperative herding groups to complex hierarchical groups with the power to conquer their sedentary neighbours. By perceiving cooperative herding groups as the building blocks of nomadic societies, this project a",{"id":339,"funder":7,"programme":8,"title":340,"piName":10,"institution":341,"country":12,"year":13,"amount":342,"abstract":343},"cordis-european-research-council-award-101043747","The Flexible Brain: (Re-)shaping Adaptation in Semantic Cognition","UNIVERSITAET LEIPZIG","€1,999,750","The human brain is flexible. Neural networks adapt to cognitive demands by flexibly recruiting different regions and connections. Flexible network adaptation enables cognitive functions such as semantic cognition: the ability to use, manipulate, and generalize knowledge. When key nodes suffer damage, networks can adapt to recover function. Yet, brain lesions often severely impair semantic cognition. How the semantic network adapts to lesions is poorly understood. My hypothesis is that disruption",{"id":345,"funder":7,"programme":8,"title":346,"piName":10,"institution":347,"country":27,"year":13,"amount":10,"abstract":348},"cordis-european-research-council-award-101044686","Towards understanding human consciousness: How internal brain states and environmental context shape our subjective experience","UNIVERSITEIT VAN AMSTERDAM","Consciousness is subjective experience, the ‘what it is likeness’, for example to perceive a certain scene or to feel joy. In the last three decades tremendous progress has been made in identifying the neural correlates of consciousness at the level of whole brain regions. Meanwhile, outside the field of consciousness, rapid progress has been made in understanding neural, biochemical and psychological factors that have to be accounted for to further understand human consciousness. Most important",{"id":350,"funder":7,"programme":8,"title":351,"piName":10,"institution":352,"country":41,"year":13,"amount":353,"abstract":354},"cordis-european-research-council-award-101045285","Dissect cargo selectivity in autophagy","UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II","€1,993,750","(Macro)autophagy is an evolutionarily conserved catabolic process induced to preserve cellular homeostasis under conditions of stress, such as nutrient starvation. Upon autophagy activation cellular components are engulfed by autophagic vesicles, which then fuse with lysosomes for substrate degradation. Despite the unquestionable physiological and medical relevance of nutrient- and pharmacological-induction of autophagy in human health, the precise identity of autophagy substrates and the rules ",{"id":356,"funder":7,"programme":8,"title":357,"piName":10,"institution":358,"country":207,"year":13,"amount":359,"abstract":360},"cordis-european-research-council-award-101043931","Towards the prevention of rebound effects within complex socio-technical systems","DANMARKS TEKNISKE UNIVERSITET","€1,999,478","Society´s most well-intended efforts to solve sustainability challenges have not yet achieved the expected gains due to rebound effects, which are unintended consequences of interventions that arise due to induced changes in system behaviour. Rebound effects are widely acknowledged, but fundamental scientific gaps hamper their prevention. REBOUNDLESS aims to develop the reboundless design theory, a paradigm shift in design science that will establish the scientific knowledge for preventing rebou",{"id":362,"funder":7,"programme":8,"title":363,"piName":10,"institution":364,"country":12,"year":13,"amount":365,"abstract":366},"cordis-european-research-council-award-101043957","Tunable Interactions in 2-dimensional Materials for Quantum Matter and Light","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€2,597,500","Interactions amongst a macroscopic number of constituents leads to emergent, collective phenomena such as magnetism and superconductivity. Quantum confinement enhances interactions between electrons leading to a wide variety of many-body quantum phases. Atomically thin layered materials such as monolayer semiconductors are prime candidates to study the effect of interactions due to extreme quantum confinement. Moreover, they offer unique features such as heterostructure assembly aided by van der",{"id":368,"funder":7,"programme":8,"title":369,"piName":10,"institution":364,"country":12,"year":13,"amount":370,"abstract":371},"cordis-european-research-council-award-101045669","Resilient and Sustainable Software Security","€1,998,851","In parallel with the ongoing digitization, computer security has become an increasingly important and urgent challenge. In particular, the sound and robust implementation of complex software systems is still not well understood in practice, as evidenced by the steady stream of successful attacks observed in the wild. The current state of the art in software security consists of solutions that are often technically sound, but do not provide operational security in practice.     With the Resilient",{"id":373,"funder":7,"programme":8,"title":374,"piName":10,"institution":375,"country":12,"year":13,"amount":376,"abstract":377},"cordis-european-research-council-award-101045454","Model-based Reinforcement Learning for Versatile Robots in the Real World","EBERHARD KARLS UNIVERSITAET TUEBINGEN","€1,998,500","REAL-RL proposes a path to autonomous robots that learn from experience. By learning to solve new and challenging tasks and exploiting their specific capabilities, they could become ubiquitous assistants to humans in an uncountable number of tasks. Current control strategies for robots are developed only for particular tasks and are not versatile. To ensure their functioning, it is necessary to have highly accurate physical models that precisely match all the essential aspects of the real world.",{"id":379,"funder":7,"programme":8,"title":380,"piName":10,"institution":381,"country":12,"year":13,"amount":10,"abstract":382},"cordis-european-research-council-award-101044011","Banking and Climate Change","JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN","Climate change is one of the key societal challenges of our generation, affecting every country, every firm, and every person on this planet for decades to come. More than half of carbon emissions arise from bank-dependent sectors of the economy; and a large part of renewable energy production is financed by banks. The banking sector plays a crucial role for lending to firms and households, for the issuance of securities, for project financing, and for mergers and acquisitions. Yet, the role of ",{"id":384,"funder":7,"programme":8,"title":385,"piName":10,"institution":386,"country":12,"year":13,"amount":28,"abstract":387},"cordis-european-research-council-award-101044226","Exact Results from Broken Symmetries","DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY","Symmetries serve as our main guide in studying physical phenomena. The more symmetric a system is, the more constrained are its degrees of freedom and the better prospects we have to understand and solve it. Significant progress has been achieved in the study of theories with high amounts of symmetry in the last decades. Supersymmetry and conformal invariance are the main reasons why the beautiful idea of holography materialised into the AdS\u002FCFT correspondence and the discovery of hidden symmetr",{"id":389,"funder":7,"programme":8,"title":390,"piName":10,"institution":306,"country":20,"year":13,"amount":10,"abstract":391},"cordis-european-research-council-award-101043981","Understanding spatial mobility from early life into adulthood","The LIFELONGMOVE project is the first of its kind to comprehensively and systematically examine spatial mobility from early age into adulthood (i.e. lifelong mobility).Research has only started to address the increasingly diverse and complex ways individuals engage in spatial mobility over the life course, and in relation to the growing inequality of opportunity. While backgrounds and circumstances in childhood shape life chances and outcomes in a later age, the extent to which childhood mobilit",{"id":393,"funder":7,"programme":8,"title":394,"piName":10,"institution":395,"country":396,"year":13,"amount":397,"abstract":398},"cordis-european-research-council-award-101043381","Tracing nanoparticle-fuelled co-mobilization of catalyst metals across Earth's deep-sea redox interfaces to pave the way for habitability detection in Ocean Worlds","MIDDLE EAST TECHNICAL UNIVERSITY","TR","€2,399,350","Redox metals such as Fe, Mo, V, Ni, Cu and Mn, supplied from deep-sea interfaces, played a pivotal role in the coupled evolution of Earth's biogeochemical cycles and life. Accordingly, future search for life in Ocean Worlds of the Solar System will greatly benefit from going beyond parameters such as water and organics, and being able to detect signs of subsurface metal catalysis. As fundamental metabolism requires metal clusters and nanoparticles; their formation, detection and link to Earth’s ",{"id":400,"funder":7,"programme":8,"title":401,"piName":10,"institution":402,"country":108,"year":13,"amount":403,"abstract":404},"cordis-european-research-council-award-101045340","Synthetic and structural biology of Rab GTPase networks","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","€1,928,624","Eukaryotic cells are characterized by their compartmentalization into hundreds of different membrane-bound organelles with unique biochemical identities. Small GTPases of the Rab family play a central role in this organization, but how they are able to generate spatiotemporal order in the complex cellular environment is currently not known. Most previous studies on Rab GTPases have either relied on describing their behavior in living cells or in highly reductionist biochemical assays. However, n",{"id":406,"funder":7,"programme":8,"title":407,"piName":10,"institution":408,"country":89,"year":13,"amount":409,"abstract":410},"cordis-european-research-council-award-101043471","Computational imaging through scattering materials using speckle correlation","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","€2,125,000","When viewed under coherent imaging conditions (e.g. laser illumination), scattering materials such as biological tissues create noise-like images known as speckle. Despite their seemingly random nature, speckle patterns have strong statistical correlation properties that are highly informative of the material producing them. These can be used to enable remarkable imaging capabilities, not possible with current state of the art, for example seeing through highly scattering layers.Unfortunately, r",{"id":412,"funder":7,"programme":8,"title":413,"piName":10,"institution":414,"country":178,"year":13,"amount":28,"abstract":415},"cordis-european-research-council-award-101044989","Tracking the deep evolutionary origins of neurons","UNIVERSITETET I BERGEN","The evolutionary origin of first neurons was key for animals as it allowed them to rapidly detect environmental cues and to coordinate responses to threats or opportunities. The evolutionary origin of neurons however remains a highly debated and largely enigmatic subject since there is no broad agreement on the relationships at the base of the animal tree and not all non-bilaterian animals have neurons. Strikingly, early branching animals, as well as their closest unicellular relatives already c",{"id":417,"funder":7,"programme":8,"title":418,"piName":10,"institution":419,"country":27,"year":13,"amount":330,"abstract":420},"cordis-european-research-council-award-101045660","Chronology of the Norse TransAtlantic Colonies and Territories","RIJKSUNIVERSITEIT GRONINGEN","For ten thousand years, the world was divided in two. Almost all human societies belonged to either the Old or the New Worlds. Amid this consummate isolation, the two worlds followed their own cultural and ecological trajectories. The loop was finally closed when the Norse arrived in the Americas in 1021 CE. However, the story of this closure ironically remains one of the most significant gaps in our knowledge of the past. This project addresses the timing, duration, geographical extent and last",{"id":422,"funder":7,"programme":8,"title":423,"piName":10,"institution":294,"country":225,"year":13,"amount":424,"abstract":425},"cordis-european-research-council-award-101044202","Molecular mechanisms and consequences of thermal stress rippling through changing aquatic environments","€1,999,845","Heat stress is a driver of current mass mortalities related to anthropogenic global warming. However, current approaches to study heat stress have not considered three major but little known aspects. These are (i) the ripple effect, which could amplify negative outcomes through propagating heat stress among organisms, (ii) heat stress as an evolutionary mutagen and (iii) genomic networks as filters for prezygotic selection, which together could speed up the process of evolutionary adaptation to ",{"id":427,"funder":7,"programme":8,"title":428,"piName":10,"institution":429,"country":108,"year":13,"amount":10,"abstract":430},"cordis-european-research-council-award-101044443","New Light On Dark Matter","OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN","Collisions of dark matter (DM) particles with nuclei or with themselves can be accompanied by the prompt production of (dark) Bremsstrahlung quanta or, in matter, by the emission of electrons. The latter is called the Migdal effect, and the former adds a dissipative process to DM self-interactions. Focusing on light, sub-GeV DM candidates, we will advance two fields of central interest to the particle physics community: the direct detection of DM in the laboratory and the DM-assisted formation o",{"id":432,"funder":7,"programme":8,"title":433,"piName":10,"institution":434,"country":34,"year":13,"amount":435,"abstract":436},"cordis-european-research-council-award-101043480","Nanofluidic Catalytic Reaction Imaging","CHALMERS TEKNISKA HOGSKOLA AB","€2,341,250","How can we “see” a catalytic reaction on a single nanoparticle? While our eyes use visible light to create a vivid perception of our world, they are unable to resolve the nanoscale. Now imagine light yet allowing us to equally vividly see a chemical process and thereby enabling us to witness how structure or chemical composition of a single nanoparticle control the rate of a catalytic reaction on its surface. To date, the lack of a suitable technique prevents this ultimate level of insight at te",{"id":438,"funder":7,"programme":8,"title":439,"piName":10,"institution":440,"country":12,"year":13,"amount":441,"abstract":442},"cordis-european-research-council-award-101045497","Endogenous Retroelements As Transcriptional Parasites And Modulators Of Host Immunity","UNIVERSITATSKLINIKUM BONN","€1,999,415","Almost half of our genome is occupied by ancient viral sequences that can be mobilized under certain conditions and either jump or copy themselves from one location to another. A group of these mobile genetic elements is called endogenous retroelements. Mobilization of retroelements like LINE1 has been shown to cause cancer via insertional mutagenesis. In recent years LINE1 activation has also been associated with the development of inflammatory diseases and inflammation-driven ageing. This mean",{"id":444,"funder":7,"programme":8,"title":445,"piName":10,"institution":446,"country":139,"year":13,"amount":447,"abstract":448},"cordis-european-research-council-award-101044906","GREENER URBAN TRAVEL ENVIRONMENTS FOR EVERYONE: From measured wellbeing impacts to Big Data analytics","HELSINGIN YLIOPISTO","€1,981,735","Greenery is an integral part of healthy and liveable urban environments. Availability of greenery is a question of environmental justice and equity. The benefits of greenery have been clearly shown in the residential context, but exposure to greenery in everyday urban travel environments has been studied much less, if at all. The project will produce a novel understanding of the quality, availability and wellbeing impacts of green urban travel environments. Furthermore, it will produce knowledge",{"id":450,"funder":7,"programme":8,"title":451,"piName":10,"institution":63,"country":12,"year":13,"amount":452,"abstract":453},"cordis-european-research-council-award-101043410","Machine Learning for Offensive Computer Security","€1,962,000","Despite a long series of research, computer attacks still pose a major threat to the security of digital systems. Different malicious actors, such as cybercriminals and intelligence agencies, continuously develop new offensive techniques to evade and outsmart existing defenses. As a result, security research is in a constant arms race and needs to anticipate novel developments as early as possible.   However, one of the key technologies of the last years, machine learning, has received very litt",{"id":455,"funder":7,"programme":8,"title":456,"piName":10,"institution":457,"country":146,"year":13,"amount":458,"abstract":459},"cordis-european-research-council-award-101044951","Mitochondrial signaling drives parasite differentiation","BIOLOGICKE CENTRUM AKADEMIE VID CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE","€1,991,125","Mitochondria perform three essential functions: ATP production, metabolite synthesis and cellular signaling. These signals, communicating the bioenergetic and biosynthetic fitness of the organelle to the nucleus, play a powerful role in determining cellular fate. The incorporation of mitochondrial reactive oxygen species (mROS) in cellular signaling is an interesting evolutionary outcome, as excess levels of these potent oxidizers have been implicated in many pathologies. While most research foc",{"id":461,"funder":7,"programme":8,"title":462,"piName":10,"institution":119,"country":89,"year":13,"amount":28,"abstract":463},"cordis-european-research-council-award-101125265","Deciphering Cancer Heterogeneity and Drug resistance using Single-Clone Genomic and Epigenomic Landscapes","To comprehend the characteristics, phylogenetic relationships, and drug resistance of tumor subclones, measurements must be performed at single-cell or single-clone resolution. Aims 1 and 2 aim to create cost-effective and reliable single-cell drop technologies for capturing full-length RNA (Scfl-RNA-Seq) and enhancers at the DNA level (ChromOpen). It is noteworthy that Scfl-RNA-Seq also captures non-coding and non-polyadenylated RNAs besides coding mRNA. ChromOpen also offers better capturing o",{"id":465,"funder":7,"programme":8,"title":466,"piName":10,"institution":241,"country":20,"year":13,"amount":467,"abstract":468},"cordis-european-research-council-award-101043751","The evolution of new organs during insects’ conquest of the sky","€1,995,263","The history of life on Earth has been defined by key game-changing events. In animals, this has often been driven by the appearance of novel organs, conferring new capabilities to explore new niches and adaptive landscapes, completely changing the subsequent evolution of certain lineages. This proposal will focus on one of the most fascinating and revolutionary events in animal history: insect’s conquest of the skies. First, by addressing the origin of the morphological change responsible for th",{"id":470,"funder":7,"programme":8,"title":471,"piName":10,"institution":472,"country":12,"year":13,"amount":473,"abstract":474},"cordis-european-research-council-award-101043372","Modeling binary neutron star from inspirals to remnants and their multimessenger emissions","FRIEDRICH-SCHILLER-UNIVERSITÄT JENA","€1,997,509","Binary neutron star mergers (BNSMs) are unique astrophysical laboratories to explore all four fundamental interactions in their extreme regimes. The landmark detection of the gravitational wave GW170817 and its counterparts in the entire electromagnetic spectrum demonstrated the enormous impact of BNSMs observations on fundamental physics and astrophysics, including the nature of matter at supranuclear densities, the origin of high-energy cosmic photons and of heavy elements. The goal of InspiRe",{"id":476,"funder":7,"programme":8,"title":477,"piName":10,"institution":478,"country":27,"year":13,"amount":10,"abstract":479},"cordis-european-research-council-award-101043431","How Mirror-Image Effects Shape Online Labour Markets","STICHTING RADBOUD UNIVERSITEIT","The 'gig economy', where workers are hired through internet platforms to complete a one-time service task (a 'gig'), is growing into a major labour market. Yet, we still lack a theory of how it develops. Its online part, including tasks to be completed at the computer (e.g. programming or translations), constitutes the first truly global labour market. Faced with unprecedented competition, most gig workers offer their services at low rates that do not allow for insurances or building up pensions",{"id":481,"funder":7,"programme":8,"title":482,"piName":10,"institution":483,"country":12,"year":13,"amount":484,"abstract":485},"cordis-european-research-council-award-101044546","The City Rising: Inequality and Mobility in a Growing Metropolis of the 19th Century","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€1,956,434","The rising industrial metropolises of the 19th century faced a series of timeless challenges: the disruptive effects of new technologies, the integration of new immigrants, the threat of epidemics. In this project we study, with the use of novel, high-quality, high-frequency individual-level archival data, how the city of Munich dealt with these challenges and provided opportunities for economic and social mobility to its dwellers, in the period 1823-1914. Our study is composed of three parts. I",{"id":487,"funder":7,"programme":8,"title":488,"piName":10,"institution":489,"country":41,"year":13,"amount":490,"abstract":491},"cordis-european-research-council-award-101044020","MAGNETIC HYPERTHERMIA FOR METASTASIZED TUMOR TREATMENT AND REMOTE MANIPULATION OF MICRODEVICES","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","€2,993,750","In magnetic hyperthermia (MHT), magnetic nanoparticles (MNPs) convert magneto-energy into heat under a time-varying magnetic field. MHT with MNPs is used in catalysis to promote reactions in solution and in cancer therapy, to ‘burn’ primary tumors in clinic, e.g. Glioblastoma, upon deposition of nanoparticles at the tumor site. The power of MHT, being an externally triggered approach to produce heat, goes beyond these actual uses. In GIULIa project I will apply MHT in tasks not yet explored to t",{"id":493,"funder":7,"programme":8,"title":494,"piName":10,"institution":440,"country":12,"year":13,"amount":495,"abstract":496},"cordis-european-research-council-award-101044133","Inflammatory signals of cell death","€1,991,250","Inflammation is a natural mechanism to restore tissue homeostasis, and its deregulation causes human disease. The programmed cell death form pyroptosis elicits inflammation in a cell-autonomous and non-autonomous fashion by releasing cytokines and ‘danger’ signals. Intriguingly, immune pathology independent of cytokines has alluded to unexplored signaling circuits between cells regulating pyroptotic inflammatory reactions.FIREALARM addresses the fundamental question of the physiological origin o",{"id":498,"funder":7,"programme":8,"title":499,"piName":10,"institution":500,"country":41,"year":13,"amount":501,"abstract":502},"cordis-european-research-council-award-101044437","Science, Society and Environmental Change in the First Millennium CE","UNIVERSITA CA' FOSCARI  VENEZIA","€1,998,963","In the Mediterranean in the first millennium CE, environmental and climatic changes have been identified as causes for significant short- and long-term societal and political processes and events, such as epidemics and the rise and fall of empires. However, the effects of environmental or climatic variation on humans are substantially more complex than a narrative of causation of major events, since culturally specific perceptions and interpretations of environmental or climatic variation can ha",{"id":504,"funder":7,"programme":8,"title":505,"piName":10,"institution":506,"country":20,"year":13,"amount":507,"abstract":508},"cordis-european-research-council-award-101045778","Atomic-Scale Tailored Materials for Electrochemical Methane Activation and Production of Valuable Chemicals","FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA","€1,999,774","Electrochemical methane activation and direct conversion to methanol is highly attractive –  a dream reaction that would convert a greenhouse gas into a valuable liquid fuel in a dream device, on-site, and powered by renewable electricity. However, sustainable C-H activation and direct methane to methanol conversion at ambient conditions remain as great fundamental challenges.My aim with ATOMISTIC is: (i) to develop new methods for electrochemical methane activation and partial oxidation, (ii) t",{"id":510,"funder":7,"programme":8,"title":511,"piName":10,"institution":512,"country":12,"year":13,"amount":513,"abstract":514},"cordis-european-research-council-award-101088970","Deciphering Cellular Networks for Membrane Protein Quality Control Decisions","TECHNISCHE UNIVERSITAET MUENCHEN","€1,975,000","Any cell and each of its organelles needs to interact with its environment. Membrane proteins, which span the plasma membrane and the multiple endomembranes of a eukaryotic cell, mediate these interactions. They allow cells to move, thrive and defend - and multicellular organisms to exist. Humans dedicate almost one third of their genes to membrane proteins. Failures in membrane protein biogenesis or function cause numerous human diseases from cancer to neurological disorders.By far most eukaryo",{"id":516,"funder":7,"programme":8,"title":517,"piName":10,"institution":512,"country":12,"year":13,"amount":10,"abstract":518},"cordis-european-research-council-award-101086997","The Glucocorticoid Receptor in Aging and Circadian Endocrinology","The pandemic is stressful for many. In response to stress, glucocorticoids are released. They play essential roles as endogenous hormones and clinically as drugs. High levels are associated with cardiometabolic disorders and with aging. In contrast, diets like caloric restriction ameliorate metabolic dysfunction and prolong lifespan. These diets, however, also increase glucocorticoids. Now the open question is: What are the molecular and physiological effects of increased hormone levels, and are",{"id":520,"funder":7,"programme":8,"title":521,"piName":10,"institution":512,"country":12,"year":13,"amount":522,"abstract":523},"cordis-european-research-council-award-101089203","Compressed Sensing for Climate: A Novel Approach to Localize, Quantify and Characterize Urban Greenhouse Gas Emitters","€1,999,848","Climate change is a defining issue of our time. Without significant, rapid greenhouse gas (GHG) emission reductions, we will face unpredictable consequences for climate and life. To effectively reduce GHGs, the emissions must be accurately quantified and unknown emitters found. However, measuring global GHG emissions is very challenging, and hence current emission inventories rely mostly on bottom-up calculations, which lack accuracy and the ability to detect unknown sources.In CoSense4Climate, ",{"id":525,"funder":7,"programme":8,"title":526,"piName":10,"institution":527,"country":528,"year":13,"amount":529,"abstract":530},"cordis-european-research-council-award-101089112","Changing Inequality at Educational Transitions","HASKOLI ISLANDS","IS","€1,999,764","EDUCHANGE aims to become one of the first ever projects to conduct simultaneous field experiments in four strategically selected countries (Denmark, Germany, Hungary, Iceland) with the goal to reduce inequality at the educational transition from compulsory to secondary education and at the transition to higher education. While experimental intervention studies have become more common in sociology and economics in recent years, EDUCHANGE will address five critical limitations in this literature: ",{"id":532,"funder":7,"programme":8,"title":533,"piName":10,"institution":534,"country":207,"year":13,"amount":535,"abstract":536},"cordis-european-research-council-award-101088901","Develop tools that use genetic data to better classify complex human diseases","AARHUS UNIVERSITET","€1,975,333","Many common diseases are highly heterogeneous, meaning that two individuals can be diagnosed with the same disease but have very different progressions or respond very differently to the same medication. These heterogeneous diseases affect a sizeable proportion of the population. For example, approximately one in four people will develop a heterogeneous brain disorder (e.g., a neurological condition such as epilepsy or Parkinson’s Disease, or a psychiatric condition such as depression or schizop",{"id":538,"funder":7,"programme":8,"title":539,"piName":10,"institution":540,"country":165,"year":13,"amount":541,"abstract":542},"cordis-european-research-council-award-101045042","Fluid-Structure Interaction and Machine Leaning for Controlling Unruptured Intracranial Aneurysms","ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS","€1,891,333","Developing new capabilities to predict the risk of intracranial aneurysm rupture and to improve treatment outcomes in the follow-up of endovascular repair is of tremendous medical and societal interest, both to support decision-making and assessment of treatment options by medical doctors, and to improve the life quality and expectancy of patients.The proposal aims at identifying and characterizing novel flow-deviator stent devices through a high-fidelity computational framework that combines st",{"id":544,"funder":7,"programme":8,"title":545,"piName":10,"institution":429,"country":108,"year":13,"amount":546,"abstract":547},"cordis-european-research-council-award-101043740","Theatre and Gentrification in the European City","€1,843,311","Since the European Middle Ages, the fates of theatre and the city have been intertwined. Mystery plays thrived amidst the urban guilds of medieval Paris, city comedies heralded merchant capitalism in seventeenth-century London, and Ottoman shadow puppetry shaped coffeehouse culture in nineteenth-century Istanbul. The emergence of the modern European city in particular was linked to the development of both state-sponsored and independent theatre institutions; theatre and performance practices dre",{"id":549,"funder":7,"programme":8,"title":550,"piName":10,"institution":101,"country":12,"year":13,"amount":551,"abstract":552},"cordis-european-research-council-award-101045468","Understanding emergent physical properties of chromatin using synthetic nuclei","€1,999,550","The main aim of this proposal is to resolve how the physics of molecular-scale activities result in the emergent material properties of chromatin and how those contribute to chromatin organization and function. Mounting evidence suggests that the material properties of chromatin regulate essential nuclear processes. Chromatin has been studied with two disconnected approaches; pure in vitro studies, perfectly suited for careful biophysical measurements on single DNA molecules but lacking the comp",{"id":554,"funder":7,"programme":8,"title":555,"piName":10,"institution":556,"country":126,"year":13,"amount":557,"abstract":558},"cordis-european-research-council-award-101044428","The role of an expanded family of exported effector kinases in environmental sensing and regulation of virulence in human malaria.","FUNDACAO GIMM - GULBENKIAN INSTITUTE FOR MOLECULAR MEDICINE","€1,999,935","The most severe form of malaria in humans is caused by Plasmodium falciparum. Cytoadhesion of infected red blood cells (iRBCs) to host endothelium and iRBC rigidification are the major contributors to pathology. Cytoadhesion is mediated by transport of a protein called PfEMP1 onto the surface of the iRBC. It prevents clearance of iRBCs in the spleen and promotes parasite survival, but can cause the obstruction of blood vessels leading to pathology. Thus, the parasite has to strike a fine balance",{"id":560,"funder":7,"programme":8,"title":561,"piName":10,"institution":562,"country":12,"year":13,"amount":563,"abstract":564},"cordis-european-research-council-award-101043991","Metastable Epiallele: Role of Epigenetic Variability for the Development of Metabolic and Endocrine Diseases","CHARITE - UNIVERSITAETSMEDIZIN BERLIN","€1,997,969","The development of obesity in industrial and low-and middle-income countries is leading to a severe burden for patients and health care systems based on associated comorbidities as cardiovascular diseases and type 2 diabetes mellitus. Apart from the genetic background, epigenetic modifications like DNA methylation are supposed to play an important role for body weight regulation. So far, epigenome-wide association studies were not able to elucidate this relationship, as most methylation differen",{"id":566,"funder":7,"programme":8,"title":567,"piName":10,"institution":568,"country":12,"year":13,"amount":569,"abstract":570},"cordis-european-research-council-award-101045257","Understanding the complex biology of AHR activation in cancer","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","€1,999,925","The aryl hydrocarbon receptor (AHR) is a critical regulator of tumor progression by modulating both tumor cell intrinsic malignant properties as well as anti-tumor immunity. However, depending on the context, the AHR can exert either tumor-promoting or tumor-suppressive effects, thus limiting its potential as a drug target. To exploit the AHR for cancer therapy a comprehensive understanding of its activation and biological outcomes is necessary. The opposing effects of the AHR in cancer likely s",{"id":572,"funder":7,"programme":8,"title":573,"piName":10,"institution":574,"country":108,"year":13,"amount":575,"abstract":576},"cordis-european-research-council-award-101043321","Deciphering the Exposome by Metabolomic Technology in Breast Cancer","UNIVERSITAT WIEN","€2,937,489","EXPOMET proposes a pioneering mass spectrometry-based platform for omic-scale assessment of chemical exposures. EXPOMET will revolutionize our perception of environmental contaminants and the influence these have on breast cancer (BC).In our ageing society, the incidence of chronic disease is constantly rising; yet, environmental drivers of disease susceptibility are poorly understood. Measuring the myriad of chemicals that humans are constantly exposed to is immensely challenging; and identifyi",{"id":578,"funder":7,"programme":8,"title":579,"piName":10,"institution":580,"country":165,"year":13,"amount":581,"abstract":582},"cordis-european-research-council-award-101044637","How do diazotrophs shape the ocean biological carbon pump? A global approach, from the single cell to the ecosystem","INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT","€2,493,821","Diazotrophs regulate marine productivity in 60% of our oceans by alleviating nitrogen limitation, contributing to carbon (C) sequestration through the N2-primed Prokaryotic C Pump (PCP). Yet we don’t know how much diazotroph-derived organic C (OC) is exported to the deep ocean, which prevents robust predictions of how the ocean contributes to CO2 sequestration and climate change mitigation. This knowledge gap is due to the multiple and complex pathways by which diazotrophs are exported to the de",{"id":584,"funder":7,"programme":8,"title":585,"piName":10,"institution":483,"country":12,"year":13,"amount":586,"abstract":587},"cordis-european-research-council-award-101043959","Extracellular vesicles-mediated cross-talk during human brain development and disease","€1,995,000","Cellular cross-talk is an essential process influenced by numerous factors including secreted vesicles that transfer nucleic acids, lipids, and proteins between cells. Extracellular vesicles (EVs) have been the center of many studies focusing on neuron-to-neuron communication while the role of EVs in progenitor-to-neuron and -astrocyte communication occurring during brain development has not been systematically investigated. Extracellular signals regulating the development of the brain are key p",{"id":589,"funder":7,"programme":8,"title":590,"piName":10,"institution":591,"country":165,"year":13,"amount":28,"abstract":592},"cordis-european-research-council-award-101089080","Role of tissue-resident FOLR2+ Macrophages as Organizers of the Tumor Immune MicroEnvironment","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","The infiltration of CD8+ T cells in tumors is crucial for the development of immunity against cancer. We have recently identified a tissue-resident macrophage population expressing the folate receptor 2 (FOLR2) and infiltrating human and murine breast tumors. We have shown that tumor-infiltrating CD8+ T cell form lymphoid aggregate around FOLR2+ macrophages in a perivascular niche. The abundance of FOLR2+ macrophages associates with lymphocyte infiltration, the onset of tertiary lymphoid structu",{"id":594,"funder":7,"programme":8,"title":595,"piName":10,"institution":596,"country":12,"year":13,"amount":597,"abstract":598},"cordis-european-research-council-award-101087673","Laminated Perovskite Photovoltaics: Enabling large area processing of durable and high efficiency perovskite semiconductor thin films.","KARLSRUHER INSTITUT FUER TECHNOLOGIE","€2,349,755","Photovoltaic technologies are cornerstones of all future scenarios for sustainable energy supply. Enhancing the efficiency and reducing the costs of photovoltaics is a challenge of utmost urgency and importance to the research field of materials engineering and science. To date, hybrid organicinorganic lead halide perovskite semiconductors denote the most promising material class for future low-cost and high-efficiency next-generation photovoltaics. Major hurdles that hinder the economic breakth",{"id":600,"funder":7,"programme":8,"title":601,"piName":10,"institution":596,"country":12,"year":13,"amount":602,"abstract":603},"cordis-european-research-council-award-101088734","Development of Suprasensors and Assays for Molecular Diagnostics","€1,994,069","SupraSense combines completely new strategies to design and realize biomimetic artificial receptors for bioactive small molecules, i.e. metabolites, with the aim of overcoming long-standing selectivity and sensitivity limitations that hindered other synthetic sensory systems from reaching diagnostic applications. Sophisticated yet easy to fabricate “SupraSensors” will be developed based on unprecedented hybrid zeolitic materials whose binding cavities are modulated by peptide-based cofactors, th",{"id":605,"funder":7,"programme":8,"title":606,"piName":10,"institution":607,"country":20,"year":13,"amount":608,"abstract":609},"cordis-european-research-council-award-101044248","Letting up senescence and inflammaging  through T cells","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","€1,999,944","With the increase in human life expectancy, there is an urgent need to understand the common molecular pathways by which aging results in a progressively higher susceptibility to chronic morbidity, disability, and frailty. In the last years, immunometabolism has emerged as a new field to boost immune responses for cancer immunotherapies as well as to dampen autoimmune diseases. A recent discovery from my lab has revealed  the critical role of T cell metabolism  in accelerating the onset of age-a",{"id":611,"funder":7,"programme":8,"title":612,"piName":10,"institution":607,"country":20,"year":13,"amount":613,"abstract":614},"cordis-european-research-council-award-101086483","Nanostructure formation during food protein digestion and influence on intestinal transport","€2,355,741","The global food system is currently facing great challenges, which are mainly motivated by environmental and health-related concerns: (i) The existing food resources are not efficiently utilized; while some of them are overexploited, causing water\u002Fsoil shortage, biodiversity losses, etc., others are not properly valorized (e.g. seaweeds). (ii) Moreover, the unhealthy dietary habits of modern societies are leading to a dramatic increase in the incidence of diet-related chronic diseases (e.g. obes",{"id":616,"funder":7,"programme":8,"title":617,"piName":10,"institution":607,"country":20,"year":13,"amount":28,"abstract":618},"cordis-european-research-council-award-101088573","Deep Earth’s Oxygen recycling at subduction Zones","In contrast to other known terrestrial planets, the Earth's interior is oxygen-breathing through the sink of oxidised tectonic plates at convergent margins since the late Archean to Paleoproterozoic. Recent estimates suggest that the redox capacity of some key subducting chemical elements is not balanced on geological time scales by global magmatism and volcanism, thus implying a puzzling deep oxygenation of our planet. Although current models presume that the redox state of subducting slabs is ",{"id":620,"funder":7,"programme":8,"title":621,"piName":10,"institution":607,"country":20,"year":13,"amount":28,"abstract":622},"cordis-european-research-council-award-101087974","COOLing for Electricity Production: Battery-free Technology","COOLed will explore the development of an innovative battery-free technology to generate electCOOLed will explore the development of an innovative battery-free technology to generate electricity using cold space in any place and at any time. COOLed proposes the powering of Internet of Things (IoT) devices in smart cities. This novel technology will combine a radiative cooler based on tri-dimensional (3D) polymer metamaterials and a thermoelectric generator of 2D transition metal selenides. The f",{"id":624,"funder":7,"programme":8,"title":625,"piName":10,"institution":626,"country":41,"year":13,"amount":627,"abstract":628},"cordis-european-research-council-award-101089107","From Niches to Norms: Drivers and Diffusion of Green Social Tipping","ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA","€1,758,084","How common must a behavior be, before a reluctant person decides to conform? And can information campaigns and behavioral interventions instigate enough change to transition to a new norm with the least disruption? The project addresses these topical questions, contributing key insights to the ecological transition. The netzero transition poses unprecedented societal challenges, that cannot be tackled with technology and markets alone. It requires behavioral and social change. Abandoning entrenc",{"id":630,"funder":7,"programme":8,"title":631,"piName":10,"institution":607,"country":20,"year":13,"amount":632,"abstract":633},"cordis-european-research-council-award-101044710","Dynamic cell wall remodeling during plant-microbe interaction","€2,699,309","Plants have a strong yet extensible wall as their outermost layer, which is indispensable for the survival of the cell and permits cell adhesion. The plant cell wall (CW) plays an essential role in response to biotic stress, as it constitutes the first contact substrate for microbes. Our findings using the model pathosystem consisting of the plant Arabidopsis thaliana and a root pathogen that can infect it, Fusarium oxysporum (Fo), confirm that the plant CW is not the static barrier it has been ",{"id":635,"funder":7,"programme":8,"title":636,"piName":10,"institution":607,"country":20,"year":13,"amount":637,"abstract":638},"cordis-european-research-council-award-101088469","Mapping vast functional landscapes with single-species resolution: a new approach for precision engineering of microbial consortia","€1,991,470","Given a list of candidate species, which community should one form to optimize a target function? Answering this fundamental ecological question is particularly urgent in the emerging field of synthetic microbial ecology, where it would dramatically improve our ability to design multi-species consortia for biotechnological applications. An empirical solution is out of reach, due to the astronomical number of possibilities: one could form ~1E30 possible assemblages from just 100 species. To provi",{"id":640,"funder":7,"programme":8,"title":641,"piName":10,"institution":642,"country":165,"year":13,"amount":643,"abstract":644},"cordis-european-research-council-award-101045774","Women at work: for a comparative history of African female urban professions (Soudn, Tanzania and Ghana), 1919-1970","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€1,822,500","WomAtWork represents the first comparative investigation into the history of female urban popular professions in three African countries – Ghana\u002FGold Coast, Sudan, and Tanganyika\u002FTanzania – over the course of fifty years (1919-1970). Not only is this topic under-studied in African history, but these professions (i.e. midwives, beauticians, wedding singers, market vendors, craftswomen) are also characterised by fascinating and unsettling aspects. For example, notions such as a set price for a ser",{"id":646,"funder":7,"programme":8,"title":647,"piName":10,"institution":648,"country":165,"year":13,"amount":10,"abstract":649},"cordis-european-research-council-award-101087830","Proteome diversification in evolution","SORBONNE UNIVERSITE","Proteins are essential and incredibly versatile actors for all biological processes in living organisms. Massive amounts of data describing their amino acid sequences and 3D shapes are now openly accessible. Yet, we still know little about how they interact and function with one another in vivo. Nor how they diversified throughout evolution to orchestrate highly specialised behavioural traits.   This ERC CoG proposal, PROMISE, meets the urgent need for decrypting protein sequences and structures",{"id":651,"funder":7,"programme":8,"title":652,"piName":10,"institution":648,"country":165,"year":13,"amount":28,"abstract":653},"cordis-european-research-council-award-101087533","Mott Insulator Transition in a Quantum Fluid of Light","Photons are great carriers of information but they usually don’t interact with one another. Atoms interact but are hard to manipulate and do not benefit from the toolbox of quantum optics for detecting quantum fluctuations and entanglement.Many approaches have been proposed to marry these two systems for quantum simulation of condensed matter with strongly interacting photons, but to date, the realization of large-scale synthetic materials made of optical photons is still missing.My project targ",{"id":655,"funder":7,"programme":8,"title":656,"piName":10,"institution":591,"country":165,"year":13,"amount":657,"abstract":658},"cordis-european-research-council-award-101043749","Identification of long-term therapeutic strategy in IgE-mediated allergy by leveraging humanized models and patient samples","€1,999,431","IgE is a key driver of allergic diseases, which affect approximately one-third of the worlds population. Monoclonal antibodies (mAbs) targeting IgE are approved for the treatment of allergic asthma, and show clinical benefit in a number of other allergic diseases. Yet, a sizable portion of patients do not respond to the drug despite high levels of IgE. There is a clear need to better define which allergy features depend (or not) on IgE, and to find predictive biomarkers in order to identify pati",{"id":660,"funder":7,"programme":8,"title":661,"piName":10,"institution":591,"country":165,"year":13,"amount":10,"abstract":662},"cordis-european-research-council-award-101043884","Circadian rhythm: from preclinical to post-diagnosis dementia","Circadian rhythm (CR) regulates body functions over the 24-hour day\u002Fnight period; sleep\u002Fwake cycle is its most visible manifestation. CR disruptions have long been observed in patients with dementia and emerging evidence points to their presence in the preclinical period of dementia. This suggests that certain aspects of CR could be useful in identification of high-risk individuals and could serve as potential targets for interventions to delay dementia onset and progression. This requires an in",{"id":664,"funder":7,"programme":8,"title":665,"piName":10,"institution":591,"country":165,"year":13,"amount":28,"abstract":666},"cordis-european-research-council-award-101087911","Mechanisms of dormancy, activation and sexual conversion in pre-erythrocytic malaria parasites","Malaria remains a devastating public health burden  the estimated death toll in 2020 was over 600,000. Its eradication is a desirable goal; however, the development of novel intervention strategies is hampered by limited current understanding of the biology of Plasmodium, the causative agent of malaria, and of its complex interactions with mammalian and mosquito hosts. In the liver, inside hepatocytes, Plasmodium parasites can either 1) replicate, forming new parasites that will infect erythrocy",{"id":668,"funder":7,"programme":8,"title":669,"piName":10,"institution":670,"country":12,"year":13,"amount":671,"abstract":672},"cordis-european-research-council-award-101088541","Species-specific aspects in eukaryotic mRNA translation modulation and their implications in diseases","UNIVERSITY OF HAMBURG","€1,999,539","mRNA translation is a universally conserved process consisting on translating the genetic code into proteins, the primary building blocks of all living organisms. Translation is mainly operated by the ribosome, a hybrid molecule made of RNAs and proteins. In most eukaryotes, at least two types of mRNA translation coexist in nearly all cells. Indeed, although the quasi totality of the proteins is translated in the cytosol by the cytosolic ribosome, a small yet essential fraction of mRNA translati",{"id":674,"funder":7,"programme":8,"title":675,"piName":10,"institution":591,"country":165,"year":13,"amount":676,"abstract":677},"cordis-european-research-council-award-101043804","Range-adapting reinforcement learning and memory","€1,995,826","A wealth of evidence in perceptual and economic decision-making research suggests that the subjective value of one option is determined by the range of the values of other available options (i.e., the context). Yet, up until today, this literature has almost exclusively focused on decision situations where contexts are explicit and static, thus ignoring more ecological and realistic scenarios where value ranges are dynamically shaped by past outcomes. This proposal will investigate if and how ra",{"id":679,"funder":7,"programme":8,"title":680,"piName":10,"institution":681,"country":41,"year":13,"amount":10,"abstract":682},"cordis-european-research-council-award-101044772","Nanoscale dynamics of volcanic processes: Experimental insights and numerical simulations of explosive eruptions","CONSIGLIO NAZIONALE DELLE RICERCHE","Volcanism is virtually ubiquitous in space and time across the universe. Its explosive expression impacts planetary evolution, life and history on Earth. The brittle  molecular  failure of magma is central to trigger explosive eruptions and yet, its occurrence is elusive to us.The mechanistic understanding of magma dynamics, combined with monitoring activities, form the basis for forecasting eruptions. This is central for modelling the impact on volcanic eruptions and determining the risk scenar",{"id":684,"funder":7,"programme":8,"title":685,"piName":10,"institution":681,"country":41,"year":13,"amount":686,"abstract":687},"cordis-european-research-council-award-101088394","Quantum interfaces with single molecules","€1,999,993","Isolating and addressing individual quantum systems has allowed for breakthrough results in quantum mechanics. Today, increasing the complexity of the system while maintaining control at the single-quantum level is vital for the next generation of quantum devices and research. QUINTESSEnCE will take up this challenge by developing interfaces between single photons, spins and phonons, all within one simple physical system, i.e. a single molecule.Fundamental systems like molecules have the inheren",{"id":689,"funder":7,"programme":8,"title":690,"piName":10,"institution":591,"country":165,"year":13,"amount":691,"abstract":692},"cordis-european-research-council-award-101087031","Harnessing the cognitive and neurophysiological processes characterising the sleep onset period","€1,995,218","Sleep often escapes us when we need it or intrudes when we would prefer to stay awake. What if we could control when we fall asleep? While our understanding of sleep has rapidly grown, what happens during the wake to sleep transition remains mysterious, potentially due to the widespread assumption that we are either awake or asleep. The current standard is to define vigilance states through coarse, physiological criteria that are visually assessed on fixed, 30s-epochs. In this framework, the sle",{"id":694,"funder":7,"programme":8,"title":695,"piName":10,"institution":696,"country":178,"year":13,"amount":697,"abstract":698},"cordis-european-research-council-award-101086671","Hibernation timing to reveal mechanisms of rheostasis","UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET","€2,161,246","HiTime is a project about the adjustment of homeostatic set points in physiology. This is known as rheostasis and is of core importance for transitions between physiological states. I seek to develop the concept that a specialised cell type in the hypothalamus, the tanycyte, is the cellular embodiment of a rheostat, and that by understanding the function of the tanycyte, we will gain fundamental insights into hypothalamic control of rheostasis. Since rheostasis is weak in laboratory mice bred to",{"id":700,"funder":7,"programme":8,"title":701,"piName":10,"institution":317,"country":12,"year":13,"amount":702,"abstract":703},"cordis-european-research-council-award-101088528","The Centre of Gravity Project","€1,999,736","The foundations of the general theory of relativity (GR) were laid by Albert Einstein in 1915. But much of what has been built on those foundations was developed in the Renaissance Period of GR between 1955 and 1975. Indeed, without the concepts and tools formed during this Renaissance, the recent observation of gravitational waves, rewarded with the Nobel Prize in physics in 2017, and the convincing prediction of and mounting evidence for the existence of black holes, rewarded with the Nobel Pr",{"id":705,"funder":7,"programme":8,"title":706,"piName":10,"institution":707,"country":12,"year":13,"amount":708,"abstract":709},"cordis-european-research-council-award-101082494","Fast-MAS Solid-State NMR as a Bypass to High-Molecular-Weight Proteins in Solution","TECHNISCHE UNIVERSITAT DORTMUND","€1,999,833","My objective is to establish methodology expanding the detailed characterization and exploitation of backbone dynamics in complex proteins up to 80-100 kDa monomer molecular weight. Experimental elucidation of protein motion is imperative for fundamental understanding of enzymatic and regulatory features. However, with a limit of regularly around 40-50 kDa maximum total mass, the more complex targets of current scientific interest usually evade solution NMR backbone resonance assignment and rema",{"id":711,"funder":7,"programme":8,"title":712,"piName":10,"institution":713,"country":41,"year":13,"amount":28,"abstract":714},"cordis-european-research-council-award-101088887","Decoding and targeting the PGE2-MEF2A axis in tumor-associated macrophages","UNIVERSITA VITA-SALUTE SAN RAFFAELE","Inflammation is a complex spectrum of processes whose outcomes range from cell killing to tissue regeneration. In this context, a major goal in immune oncology is the development of treatments that stimulate cytotoxic immunity while limiting repair in the tumor microenvironment (TME), as these approaches have the potential to synergize with available immunotherapies and provide benefit to otherwise resistant patients. Pancreatic cancer is a largely incurable disease, in which aberrant inflammati",{"id":716,"funder":7,"programme":8,"title":717,"piName":10,"institution":364,"country":12,"year":13,"amount":718,"abstract":719},"cordis-european-research-council-award-101087404","Neural Circuits Enabling Navigational Simulations","€1,994,360","One of the most notable features of the brain is the ability to simulate possible consequences of a behavioural choice that has not even been experienced in the real world. While this ability is likely fundamental for our intelligence and creativity, its neural circuit basis is largely unclear. To tackle this problem, we will focus on the rat’s ability of spatial navigation, finding an optimal path to a remote destination that is located outside the range of sensory perception. This ability is t",{"id":721,"funder":7,"programme":8,"title":722,"piName":10,"institution":723,"country":12,"year":13,"amount":724,"abstract":725},"cordis-european-research-council-award-101087245","Measuring and Modelling Tectonic CO2 Emissions Through Time","GFZ HELMHOLTZ-ZENTRUM FUR GEOFORSCHUNG","€1,999,991","Geological processes governed paleo-atmospheric CO2 variations and exerted major control on past climate change beyond the million-year time scale. Vast deep carbon reservoirs are known to be activated at continental rifts, where the faulted lithosphere provides CO2 pathways and where recent surveys detected massive CO2 emissions. However, progress in quantifying natural CO2 degassing and its impact on past climate is impeded for 3 reasons: (1) current CO2 flux measurement techniques require lab",{"id":727,"funder":7,"programme":8,"title":728,"piName":10,"institution":95,"country":12,"year":13,"amount":729,"abstract":730},"cordis-european-research-council-award-101087755","DIVerse Exoplanet Redox State Estimations","€1,993,270","New observational capabilities with the JWST and ARIEL space telescopes will strongly advance our ability to characterize exoplanetary atmospheres. While the community focusses mainly on biosignatures, in DIVERSE I will search for signatures of geophysical factors that influence habitability, specifically the diversity of planetary redox states. The redox state is of major importance for habitability, since reducing conditions favour prebiotic chemistry for life as we know it. Atmospheres of roc",{"id":732,"funder":7,"programme":8,"title":733,"piName":10,"institution":119,"country":89,"year":13,"amount":28,"abstract":734},"cordis-european-research-council-award-101088943","Chromatic Algebraic Geometry","Stable homotopy theory provides a powerful framework for the study of algebra in the homotopy coherent setting. Its central notion is that of a spectrum, which is the homotopical generalization of an abelian group. Spectra appear naturally in a wide range of mathematical fields from number theory to differential topology, as they encode in a highly structured fashion various fundamental invariants, such as the algebraic K-theory groups of a ring and the cobordism classes of manifolds. The tools ",{"id":736,"funder":7,"programme":8,"title":737,"piName":10,"institution":738,"country":34,"year":13,"amount":10,"abstract":739},"cordis-european-research-council-award-101087343","Microwave Quantum Photonics for Quantum Technology and Fundamental Physics","LUNDS UNIVERSITET","With the proposed research programme we plan to pioneer a platform that provides experimental access to the statistics of the microwave photons, thus opening up single-photon experiments in solid-state quantum devices.Microwave photons play a major role throughout all solid-state quantum technology architectures, including superconducting qubits as well as charge and spin qubits in semiconductors, where they are used for control, coupling and readout. However, the particle nature of the photons ",{"id":741,"funder":7,"programme":8,"title":742,"piName":10,"institution":743,"country":41,"year":13,"amount":744,"abstract":745},"cordis-european-research-council-award-101086988","MApping the Methylation of repetitive elements to track the Exposome effects on health: the city of Legnano as a LIving lab","UNIVERSITA DEGLI STUDI DI MILANO","€2,993,251","The concept of exposome encompasses all human disease determinants encountered during the life course. The exposome induces epigenetic modifications (e.g., DNA methylation). Several studies have investigated how repetitive elements (REs) can be switched on in response to environmental stimuli, but have started from the assumption that altered RE methylation is always detrimental to the health of the affected individual. MAMELI proposes an alternative hypothesis that some REs are plastic entities",{"id":747,"funder":7,"programme":8,"title":748,"piName":10,"institution":749,"country":207,"year":13,"amount":750,"abstract":751},"cordis-european-research-council-award-101087058","NEUTRINO QUANTUM KINETICS","KOBENHAVNS UNIVERSITET","€2,027,474","This project aims at solving one of the most urgent riddles in particle astrophysics: how neutrinos affect the physics of spectacular cosmic fireworks in the death of massive stars as core-collapse supernova explosions and in the merger of two neutron stars or a neutron star and a black hole. Neutrinos are feebly interacting particles copiously produced in these dense sources. Neutrinos exist in three different kinds, or flavors, and have the fascinating property of changing their flavor while p",{"id":753,"funder":7,"programme":8,"title":754,"piName":10,"institution":119,"country":89,"year":13,"amount":755,"abstract":756},"cordis-european-research-council-award-101088881","Uncovering molecular and cellular mechanisms of immune cell trafficking across the blood-CSF barrier in autoimmunity","€2,412,448","Immune cells continuously traverse our body, crossing vascular and epithelial barriers; from lymphatic organs into the blood, and from the blood into various tissues for surveillance or to fight infection. However, the brain has long been considered an immune-privileged organ. Barriers protecting the brain against infection or harmful toxic agents were also thought to block entry of immune cells, leaving immune functions to brain-resident microglia cells. This dogma was recently overturned when ",{"id":758,"funder":7,"programme":8,"title":759,"piName":10,"institution":760,"country":165,"year":13,"amount":761,"abstract":762},"cordis-european-research-council-award-101088827","Towards a Unified Macro-Distributional Analysis of Globalization","ECOLE D'ECONOMIE DE PARIS","€1,698,500","Which social groups have most benefitted from financial globalization since the 1980s? How would inequality have evolved if, instead of tax competition, countries had chosen tax harmonization? The goal of this project is to address these questions in a unified framework and using new data. This proposal builds on my previous work and consists of two parts. First, I will create prototype Global Flows of Funds: comprehensive statistics of the ownership of global assets by country of the owner and ",{"id":764,"funder":7,"programme":8,"title":765,"piName":10,"institution":766,"country":767,"year":13,"amount":768,"abstract":769},"cordis-european-research-council-award-101088124","Real-Time Urban Mobility Management via Intelligent UAV-based Sensing","UNIVERSITY OF CYPRUS","CY","€1,999,938","Inefficient management of urban mobility leads to congestion with several socioeconomic and environmental adverse effects. Despite numerous research efforts and deployed technological solutions to address congestion, the problem still persists. One of the main reasons is attributed to the sparsity and low quality of traffic data. Unmanned Aerial Vehicles (UAVs) are an emerging, non-invasive, vision-based traffic sensing technology that offers economic viability and fast deployment. UAVs can swif",{"id":771,"funder":7,"programme":8,"title":772,"piName":10,"institution":773,"country":41,"year":13,"amount":774,"abstract":775},"cordis-european-research-council-award-101086695","Assessing Philosophical Authors and Texts from Herculaneum and elsewhere on Early Stoicism: Insights into ancient logic, physics, and ethics towards a new von Arnim","UNIVERSITA DEGLI STUDI DI TORINO","€1,999,587","Alongside Epicurus school, Stoicism is the most important current of thought in Hellenistic philosophy. The first phase of this school extends from Zeno of Citium (334\u002F333262\u002F261 BCE) to Chrysippus followers (viz. up to the end of the 2nd century BCE). Apart from some fragments transmitted by the medieval manuscript tradition and by the Herculaneum papyri, only indirect witnesses on the early Stoics remain today. The huge corpus of this material was collected mostly in Hans von ArnimsStoicorum V",{"id":777,"funder":7,"programme":8,"title":778,"piName":10,"institution":779,"country":139,"year":13,"amount":10,"abstract":780},"cordis-european-research-council-award-101087499","Multi-scale incidence geometry","JYVASKYLAN YLIOPISTO","The ERC CoG project MUSING aims to make progress in several old problems in geometric measure theory (GMT), including Vitushkin's conjecture from the 60s, and the Furstenberg set conjecture proposed by Wolff in the 90s. Both problems are related to sharpening and generalising some cornerstone results in GMT, such as the projection theorems of Besicovitch and Marstrand. Recent work on these questions combines techniques from GMT, additive combinatorics, harmonic analysis, and incidence geometry. ",{"id":782,"funder":7,"programme":8,"title":783,"piName":10,"institution":784,"country":41,"year":13,"amount":785,"abstract":786},"cordis-european-research-council-award-101087295","A revolutionary archaeological Pb observatory for astrophysical neutrino sources","UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA","€2,661,005","One of the most energetic events in the Universe is the core-collapse Supernova (SN) where almost all the star's binding energy is released as neutrinos. These particles are direct probes of the processes occurring in the stellar core and provide unique insights into the gravitational collapse and the neutrino properties. Currently, astroparticle physics is in need of SN observations and of a detection technique highly sensitive to all neutrino flavors.RES-NOVA will revolutionize how we detect n",{"id":788,"funder":7,"programme":8,"title":789,"piName":10,"institution":408,"country":89,"year":13,"amount":28,"abstract":790},"cordis-european-research-council-award-101089009","4D Brain-Targeting Nanomedicines for Treating Neurodegeneration","Aging, Aging, genetic, and environmental factors have increased the prevalence of patients with neurodegenerative brain conditions, with limited treatment modalities. One prerequisite for effective brain treatments is the ability to target next-generation medications, including RNA and protein drugs, to specific neurons and brain regions. Nanotechnology platforms offer new therapeutic avenues for targeting drugs to organs and cells; their implementation in neurodegenerative diseases is nascent. ",{"id":792,"funder":7,"programme":8,"title":793,"piName":10,"institution":642,"country":165,"year":13,"amount":794,"abstract":795},"cordis-european-research-council-award-101088089","Evolutionary feedback between traits and species diversification: convergence and divergence in sympatric butterflies of the Amazonian rainforest","€1,991,768","This project will bridge gaps between micro and macro evolution by ascertaining the evolutionary feedbacks between trait and species diversification, focusing on closely-related species living in sympatry. Sympatric species often differ in suites of traits involved in niche partitioning: how do ecological interactions induce the sequential evolution of series of traits? In turn, how does phenotypic divergence open up new niches and fuel sympatric speciation? The project focuses on the neo-tropic",{"id":797,"funder":7,"programme":8,"title":798,"piName":10,"institution":164,"country":165,"year":13,"amount":799,"abstract":800},"cordis-european-research-council-award-101088307","Data and Market Power in the Digital Economy","€1,287,813","Improvements in technology are enabling firms to collect and process increasingly large amounts of detailed information about their customers and their competitors. This growing use of data is fundamentally changing the nature of competition. For example, it is affecting i) how firms compete, as they offer collections of services, ii) the level at which firms compete, as they make personalised offers to individual consumers, and iii) the complexity of firms’ strategies, as they increasingly dele",{"id":802,"funder":7,"programme":8,"title":803,"piName":10,"institution":804,"country":12,"year":13,"amount":805,"abstract":806},"cordis-european-research-council-award-101087838","International Finance and the Great Powers, 1800-2020","INSTITUT FUER WELTWIRTSCHAFT LEIBNIZ ZENTRUM ZUR ERFORSCHUNG GLOBALER OKONOMISCHER HERAUSFORDERUNGEN","€1,997,244","The world is entering a new era of great power rivalry, with the rise of China and the Russia-Ukraine war being only the most visible signs. This proposal asks: What are the implications of these developments for global finance? Will China’s rise accelerate financial globalization or rather reverse it? What do the growing tensions between great powers imply for financial markets around the world? And what motivates China to invest trillions of dollars of state funds into its Belt and Road Initia",{"id":808,"funder":7,"programme":8,"title":809,"piName":10,"institution":810,"country":20,"year":13,"amount":811,"abstract":812},"cordis-european-research-council-award-101087014","Unveiling the nature of superconductivity in moiré quantum matter","FUNDACION DONOSTIA INTERNATIONAL PHYSICS CENTER","€2,802,250","Graphene moiré materials constitute a new paradigm in condensed matter physics for the study of superconductivity and other collective electronic phases given their chemical and structural simplicity as well as large tunability as compared to other many-body systems. However, a comprehensive picture of the fundamental properties of superconductivity in graphene moiré materials is still missing due to the limited information attained so far at the microscopic level. Therefore, the need for local ",{"id":814,"funder":7,"programme":8,"title":815,"piName":10,"institution":816,"country":82,"year":13,"amount":817,"abstract":818},"cordis-european-research-council-award-101089093","Thermalization at High Energies","UNIVERSITEIT GENT","€1,950,000","Thermalization of closed quantum systems is central to the modern understanding of matter, from ultracold to ultrahot. High-TheQ studies thermalization of quantum fields excited by nuclear collisions at RHIC and LHC to energy densities equivalent to trillions of Kelvins. In such extreme environments hadrons melt and the equilibrium state is the quark-gluon plasma. Theoretical control over thermalization at high energies is crucially needed for understanding when and how this equilibrium phase em",{"id":820,"funder":7,"programme":8,"title":821,"piName":10,"institution":779,"country":139,"year":13,"amount":822,"abstract":823},"cordis-european-research-council-award-101088884","Entangled tertiary folds","€1,999,454","The most sophisticated functions of proteins emerge at the level of their tertiary structure and involve large amplitude conformational changes. In contrast, the functions of synthetic molecules are currently limited by our inability to control their structure beyond the level of static secondary structures. ProteoKnot seeks to address this limitation by introducing entanglements as a tool to control tertiary folding while maintaining the flexibility required to allow them to change conformation",{"id":825,"funder":7,"programme":8,"title":826,"piName":10,"institution":827,"country":82,"year":13,"amount":828,"abstract":829},"cordis-european-research-council-award-101085607","Beyond Low-Rank Factorizations","UNIVERSITE DE MONS","€1,982,515","Low-rank matrix factorizations (LRMFs), such as principal component analysis, nonnegative matrix factorization and sparse component analysis, are linear dimensionality reduction techniques and are powerful unsupervised models to represent and analyze high-dimensional data sets. They are used in a wide variety of areas such as machine learning, signal processing, and data mining. Many LRMFs have been proposed in the literature, in particular in the last two decades, and used extensively in many a",{"id":831,"funder":7,"programme":8,"title":832,"piName":10,"institution":833,"country":82,"year":13,"amount":834,"abstract":835},"cordis-european-research-council-award-101088865","Outplaying the hardware lottery for embedded AI","KATHOLIEKE UNIVERSITEIT LEUVEN","€1,995,750","The next wave of smart applications in our society will need embedded devices (robots, wearables, etc.) with increased intelligence at much reduced energy and latency cost. Compared to current embedded platforms, up to 1000x efficiency gains could be achieved through tight processor-algorithm co-optimization. However, due to the slow development cycle of processor chips (many months to years) in comparison to algorithms (hours to weeks), this co-optimization today merely boils down to selecting ",{"id":837,"funder":7,"programme":8,"title":838,"piName":10,"institution":839,"country":27,"year":13,"amount":28,"abstract":840},"cordis-european-research-council-award-101087812","Engineering nanoparticle-polymer interactions to create instructive, tough nanocomposite hydrogels without negatively impacting self-healing behavior for bone tissue regeneration","UNIVERSITEIT MAASTRICHT","Self-healing hydrogels are investigated as promising biomaterials in tissue and organ regeneration applications, offering a powerful alternative for scarce donor tissue. However, these hydrogels are often insufficiently tough, which is a significant limitation in their clinical use. Another drawback is that there are limited solutions on how to instruct cells for tissue healing. Thus, one key challenge is to develop self-healing hydrogels that are mechanically strong and can guide tissue regener",{"id":842,"funder":7,"programme":8,"title":843,"piName":10,"institution":844,"country":27,"year":13,"amount":845,"abstract":846},"cordis-european-research-council-award-101087701","Screening And Future Enhanced MRI","STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM","€2,984,796","SAFE-MRI aims to prevent needless mortality from breast cancer by optimizing the use and performance of dedicated breast MRI.First SAFE-MRI aims at detecting breast cancer early in women that are currently deemed too young for population screening (age 45-50). Early diagnosis of breast cancer in these women will lead to a large gain in DALYs averted. I will initiate a prospective screening study inviting women to a one-time only abbreviated breast MRI at the age of 45. The primary outcome will b",{"id":848,"funder":7,"programme":8,"title":849,"piName":10,"institution":850,"country":12,"year":13,"amount":28,"abstract":851},"cordis-european-research-council-award-101086951","Carbanions as Functional Groups and Building Blocks for Novel Reagents, Catalysts and Materials","RUHR-UNIVERSITAET BOCHUM","Carbanionic compounds such as organolithium or Grignard reagents are important organometallic reagents and commonly used in organic synthesis for difficult deprotonation or C-C bond formation reactions. Due to the strongly polarized metal carbon bond these reagents are usually highly reactive and sensitive towards air and moisture and thus must be handled under strictly anhydrous conditions. Owing to this intrinsic reactivity, carbanionic compounds are usually only prepared in situ and scarcely ",{"id":853,"funder":7,"programme":8,"title":854,"piName":10,"institution":364,"country":12,"year":13,"amount":855,"abstract":856},"cordis-european-research-council-award-101089198","The Microbiota-Root-Shoot Axis in Plant Health and Disease","€1,999,975","Since 450 million years, roots of healthy plant are colonised by diverse communities of bacteria, fungi, and oomycetes which are known to extend host functions by protecting roots from disease or by promoting water and nutrient acquisition. More remarkably, recent evidence suggests that bidirectional signalling between belowground microbial commensals and distant aboveground host organs is likely critical for maintaining host-microbe homeostasis and plant health. Reminiscent of the critical role",{"id":858,"funder":7,"programme":8,"title":859,"piName":10,"institution":670,"country":12,"year":13,"amount":860,"abstract":861},"cordis-european-research-council-award-101086573","Enhanced Biomass Valorisation by Engineering of Polyoxometalate Catalysts","€1,996,625","This project builds on a recent and ground-breaking discovery of the PI in the field of homogeneously catalysed, selective biomass valorisation. Materials technologies that promise improved catalytic performance are of utmost interest for a more sustainable chemical industry. Manipulating molecular catalysts like polyoxometalates (POM) in solution by tuning the solvent properties and gas atmospheres introduces a new paradigm in homogeneous-catalysed biomass valorisation technologies.It has been ",{"id":863,"funder":7,"programme":8,"title":864,"piName":10,"institution":317,"country":12,"year":13,"amount":865,"abstract":866},"cordis-european-research-council-award-101087575","Stabilising autopolyploid meiosis for enhanced yield","€1,977,285","Hybrid breeding has been one of the biggest contributors to yield increase of the last century. Hybrids are individuals which have genetically different parents, which results in a “hybrid vigour” effect. This hybrid vigour effect can confer advantages over inbred parent lines in growth, yield, and resilience and tolerance to different types of environmental stresses, important for securing agricultural production in a changing climate. An even greater hybrid vigour effect is possible in autopol",{"id":868,"funder":7,"programme":8,"title":869,"piName":10,"institution":870,"country":207,"year":13,"amount":871,"abstract":872},"cordis-european-research-council-award-101087925","PERSONALIZED NON-INVASIVE NEUROMODULATION IN PAIN","AALBORG UNIVERSITET","€1,618,278","Chronic pain (CP) is the most prevalent disease worldwide and is a major societal challenge. Different people with the same pain condition experience it differently. Irrespective of its origin, CP is maintained by altered connectivity between brain regions, which can be modulated towards normality by effective treatment.  Several pharmacological and non-pharmacological strategies exist to treat pain, but 40% of individuals remain symptomatic despite treatment. Current treatment for CP is not per",{"id":874,"funder":7,"programme":8,"title":875,"piName":10,"institution":876,"country":12,"year":13,"amount":877,"abstract":878},"cordis-european-research-council-award-101089133","Systematically Dissecting the Regulatory Logic of Chromatin Modifications","EUROPEAN MOLECULAR BIOLOGY LABORATORY","€1,999,565","Chromatin modifications are a key mechanism for regulating gene expression patterns in normal and disease settings. Nonetheless, despite the ubiquity of epigenomics data, the causal functions of specific chromatin modifications have proved challenging to unravel. This knowledge gap reflects limited approaches to dissect how chromatin modifications influence transcription quantitatively and context-dependently, across diverse genomic features or variants in any given cell-type. Here, we propose t",{"id":880,"funder":7,"programme":8,"title":881,"piName":10,"institution":816,"country":82,"year":13,"amount":28,"abstract":882},"cordis-european-research-council-award-101086145","Memory dependent PAth Sampling methods for understanding long TIMEscale molecular processes","Time matters: timescales determine the fate, behavior and functionality of living matter. Especially the interplay between fast and slow molecular processes is omnipresent in biochemistry (protein folding, enzymatic conversions, molecular signaling, etc.). However, in chemistry, models are lacking to properly understand time and its effect on this difficult biological reality.PASTIME will lay the methodological foundations for a correct understanding of time in chemistry by introducing memory de",{"id":884,"funder":7,"programme":8,"title":885,"piName":10,"institution":288,"country":27,"year":13,"amount":886,"abstract":887},"cordis-european-research-council-award-101087365","Surfaces on fourfolds","€1,870,000","Enumerative geometry is the field of algebraic geometry dealing with counting geometric objects satisfying constraints. For instance, in Ancient Greece, Apollonius asked how many circles are tangent to three given circles in the plane. It is a very active area due to unexpected connections with other fields of mathematics and physics. So far, modern enumerative geometry is largely about counting curves. Recently I worked on foundations for a theory for counting surfaces in 4-dimensional spaces. ",{"id":889,"funder":7,"programme":8,"title":890,"piName":10,"institution":189,"country":20,"year":13,"amount":891,"abstract":892},"cordis-european-research-council-award-101086622","FLEX-based inferring of terrestrial photosynthesis dynamics for quantifying European vegetation productivity","€1,999,943","Photosynthesis, the biochemical process by which vegetation harvests sunlight to convert carbon dioxide and water into carbohydrates and O2, fuels all life on Earth and drives the global carbon cycle. Although the majority of absorbed light is used for carbon assimilation, a remaining part is lost as heat and dissipated as emissions of solar-induced chlorophyll fluorescence (SIF). SIF, the radiant flux emitted between 650 and 800 nm, is therefore the most direct measurable reporter of photosynth",{"id":894,"funder":7,"programme":8,"title":895,"piName":10,"institution":402,"country":108,"year":13,"amount":896,"abstract":897},"cordis-european-research-council-award-101086580","Action Selection in the Midbrain: Neuromodulation of Visuomotor Senses","€1,998,430","In an ever-changing natural world, animals must constantly adapt their behavior by extracting relevant information from the environment in a context-dependent manner. This is a complex task because the relevance of sensory stimuli rapidly changes according to the animal’s internal states, evidence, attention and goals. In the brain, neuromodulatory systems are thought to encode environmental and internal signals, such as novelty, reward, effort and risk, providing critical input to ensure approp",{"id":899,"funder":7,"programme":8,"title":900,"piName":10,"institution":901,"country":165,"year":13,"amount":902,"abstract":903},"cordis-european-research-council-award-101087696","Reconciling Classical and Modern (Deep) Machine Learning for Real-World Applications","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","€1,999,375","Despite the undeniable success of machine learning in addressing a wide variety of technological and scientific challenges, the current trend of training predictive models with an evergrowing number of parameters from an evergrowing amount of data is not sustainable. These huge models, often engineered by large corporations benefiting from huge computational resources, typically require learning a billion or more of parameters. They have proven to be very effective in solving prediction tasks in",{"id":905,"funder":7,"programme":8,"title":906,"piName":10,"institution":907,"country":165,"year":13,"amount":908,"abstract":909},"cordis-european-research-council-award-101088411","A Learning-from-Prices view of Inflation and Business Cycles","ETABLISSEMENT D'ENSEIGNEMENT SUPERIEUR CONSULAIRE HAUTES ETUDES COMMERCIALES DE PARIS","€1,147,981","The Eurozone is currently facing a sudden and sharp increase in inflation. Whether inflationary pressures will persist and what will be the cost of an eventual monetary tightening crucially depends on inflation expectations. The aim of this project is to provide theoretical and empirical support to a new channel, through which inflation may persistently shift business activity. The project sheds new light on how market prices influence consumers perceived inflation and how this may allow for the",{"id":911,"funder":7,"programme":8,"title":912,"piName":10,"institution":88,"country":89,"year":13,"amount":913,"abstract":914},"cordis-european-research-council-award-101087502","The Praxis of Coexistence: A Comparative and Inductive Approach to the Challenges of Diversity","€1,968,750","The world is experiencing what many have described as a crisis of multiculturalism. Over the past decade, growing and increasingly mainstream voices have declared multiculturalism to have failed, in such places as Europe, the United States, India, Israel, to name a few. In view of growing concerns over the ineffectiveness of current coexistence policies, and brewing ethno-religious conflicts, this research program will address this issue by taking a comparative approach to the question of ethno-",{"id":916,"funder":7,"programme":8,"title":917,"piName":10,"institution":918,"country":165,"year":13,"amount":342,"abstract":919},"cordis-european-research-council-award-101088708","Computational Design of Multimodal Tactile Feedback within Immersive Environments","INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE RENNES","These last years have seen an explosion of novel tactile technologies providing various haptic sensations across all the user's body. However, while these technologies have now been made available, virtual reality systems are still struggling to convey compelling tactile sensations for 3D interaction. As of today, tactile feedback mainly fails: (1) to render multiple haptic stimuli in a spatially coherent manner, (2) to achieve temporal integration of the stimuli compatible with the interactive ",{"id":921,"funder":7,"programme":8,"title":922,"piName":10,"institution":923,"country":82,"year":13,"amount":924,"abstract":925},"cordis-european-research-council-award-101088919","In Silico Trials for Cartilage Regenerative Medicine Applications","UNIVERSITE DE LIEGE","€2,212,385","Osteoarthritis (OA) is a highly prevalent disease, affecting 1 in 8 adults worldwide and is projected to increase by 60% in the next two decades. Due to the intricate interplay between multiple influencing factors such as mechanical loading and inflammation playing out over multiple length scales and tissue compartments, currently no disease-modifying drugs are available on the market. The INSTAnt CARMA project aims to harness the power of in silico trials to study OA onset and progression, as w",{"id":927,"funder":7,"programme":8,"title":928,"piName":10,"institution":88,"country":89,"year":13,"amount":28,"abstract":929},"cordis-european-research-council-award-101088955","Neuronal control of fascia","The fascia is the largest tissue in the body, yet most of us never heard of it. This connective tissue delineates the skin, surrounds muscles, and closely envelops all organs. Clinically, it is mainly considered a mechanical barrier separating organs and muscles. But why should a simple barrier be populated with immune cells and receive extensive innervation by sensory and sympathetic neurons? Here we propose that the fascia generates a sensory platform that detects damage to the tissues it enve",{"id":931,"funder":7,"programme":8,"title":932,"piName":10,"institution":446,"country":139,"year":13,"amount":933,"abstract":934},"cordis-european-research-council-award-101088532","Properties of Units and Standards","€1,719,081","We are constantly surrounded by measuring systems ranging from pedometrics, timesheets, and impact factors to carbon footprints, happiness barometers, or risk assessments. Quantity-assessment systems are always at work to allocate value to our actions.This research project sets out to study diverse valuation regimes with an emphasis on their material and conceptual linkages with the worlds they measure. The project studies the properties of different units, measures, and standards to analyse how",{"id":936,"funder":7,"programme":8,"title":937,"piName":10,"institution":938,"country":41,"year":13,"amount":939,"abstract":940},"cordis-european-research-council-award-101087978","Great Expectations: Macroeconomic Implications of Forecasting Behavior","UNIVERSITA COMMERCIALE LUIGI BOCCONI","€1,532,955","The goal of this proposal is to advance the research frontier on expectations formation and their economic impact. The proposal consists of three related projects that, through the provision of novel empirical evidence and the design of a new theoretical framework, can guide future research and better inform policy decisions. Recent empirical evidence suggests that expectations react to shocks sluggishly, but—one might argue—this may only be the case because data was gathered under stable econom",{"id":942,"funder":7,"programme":8,"title":943,"piName":10,"institution":784,"country":41,"year":13,"amount":944,"abstract":945},"cordis-european-research-council-award-101087053","The acquisition of new meanings through novel word learning","€1,387,005","We learn new words almost on a daily basis: as adults, a new element is introduced in our vocabulary every other day. With new words, we also learn about new objects and ideas - in most cases new words are not simply additional labels to be applied to familiar objects: they connote meanings that are unknown to the speaker of a language. However, when we experience, as adults, an unfamiliar word, typically its referent is not immediately available in the same context. How then can language, by it",{"id":947,"funder":7,"programme":8,"title":948,"piName":10,"institution":949,"country":12,"year":13,"amount":950,"abstract":951},"cordis-european-research-council-award-101087590","Evolutionary Government: Origins and Consequences of Structural Change in Government","UNIVERSITAET POTSDAM","€1,999,723","Why do government structures change? Traditionally, the answer refers to political parties exercising control over a state bureaucracy. Yet government structures have been changing ever since they emerged alongside the modern state and thus already before parties existed. The recent decline of party government worldwide also begs the question whether other actors and mechanisms matter that have been underestimated so far. Meanwhile, it became a truism that structure shapes policy, but existing r",{"id":953,"funder":7,"programme":8,"title":954,"piName":10,"institution":955,"country":165,"year":13,"amount":956,"abstract":957},"cordis-european-research-council-award-101087025","The Bootstrap Program for Quantum Field Theory","ECOLE POLYTECHNIQUE","€1,930,051","The importance of quantum field theory (QFT) in modern theoretical physics is hard to overstate. Nevertheless a proper mathematical framework to describe field theories is still lacking. This is felt most concretely in the world of scattering amplitudes, whose general properties are difficult to define from existing axioms. This hampers our ability to make progress in understanding strongly coupled field theories. In contrast, for conformal field theories (CFTs) there has been remarkable progres",{"id":959,"funder":7,"programme":8,"title":960,"piName":10,"institution":402,"country":108,"year":13,"amount":28,"abstract":961},"cordis-european-research-council-award-101087907","A quantum hybrid of atoms and milligram-scale pendulums: towards gravitational quantum mechanics","Does gravity obey the laws of quantum mechanics?  Can gravitational fields exist in superposition states or mediate entanglement? These questions lie at the frontier of physics and have crucial implications affirmation would constitute a union of the gravitational and quantum realms, while negative results would demand a revision of fundamental physical laws. Only recently have we identified potential paths to entertain experiments to address these questions. Daunting technical challenges nevert",{"id":963,"funder":7,"programme":8,"title":964,"piName":10,"institution":965,"country":12,"year":13,"amount":966,"abstract":967},"cordis-european-research-council-award-101087573","Mainstreaming Social-Ecological Sufficiency: Closing the sustainable consumption gap between societal demand and ecological limits","LEUPHANA UNIVERSITAT LUNEBURG","€1,981,765","Mainstreaming Social-Ecological Sufficiency: Closing the sustainable consumption gap between societal demand and ecological limitsGlobal patterns of production and consumption are fundamentally unsustainable, threatening key planetary boundaries—earth system processes vital for maintaining of ecological integrity and human well-being. Strategies for averting this ‘ecological overshoot’ have largely focused on ‘greening’ production by reducing the material intensity (efficiency), or the material ",{"id":969,"funder":7,"programme":8,"title":970,"piName":10,"institution":971,"country":12,"year":13,"amount":972,"abstract":973},"cordis-european-research-council-award-101086081","Fever. Global Histories of (a) Disease, 1750–1840","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","€1,730,895","Fever is one of the most basic and pervasive of human experiences. Even before the current COVID-19 pandemic took this to new extremes, fever and the attendant sensations  of burning up, or having ones temperature taken  had long been familiar to men, women and, indeed, children. While fever is a universal feature of humans material existence, however, its relevance and meaning differed from one historical context to another. The proposed ERC project studies fever globally, particularly in socie",{"id":975,"funder":7,"programme":8,"title":976,"piName":10,"institution":977,"country":12,"year":13,"amount":978,"abstract":979},"cordis-european-research-council-award-101088303","Laser-Based Infrared Vibrational Electric-Field Fingerprinting","RHEINLAND-PFALZISCHE TECHNISCHE UNIVERSITAT","€1,881,875","A biological system’s phenotype and the evolution thereof are mirrored in molecular composition. The complexity of biological samples, however, renders quantitative, multivariate molecular probing challenging, in particular for non-destructive, label-free approaches. Vibrational spectroscopies capture signals from all molecular bonds exchanging energy with an optical excitation, delivering highly-specific optical fingerprints of samples in their native state, to which virtually all molecules con",{"id":981,"funder":7,"programme":8,"title":982,"piName":10,"institution":983,"country":82,"year":13,"amount":10,"abstract":984},"cordis-european-research-council-award-101089193","Multi-omics characterization of immune triggers in Moyamoya disease","VIB VZW","This project aims to characterize a recently discovered link between a rare genetic disorder of the brain, called Moyamoya disease (MMD), and the cellular immune response against microbial infections. MMD is characterized by a progressive occlusion of arteries at the base of the brain leading to stroke. Mutations in Ring Finger Protein 213 (RNF213) represent the most common genetic cause of MMD, however, it is suggested that environmental stimuli are needed to trigger disease onset in genetic ca",{"id":986,"funder":7,"programme":8,"title":987,"piName":10,"institution":562,"country":12,"year":13,"amount":988,"abstract":989},"cordis-european-research-council-award-101088502","Simple minds – competition of parallel neural filters in behaviour selection of Drosophila","€2,477,303","How we and other animals make up our minds is an everlasting question that has occupied philosophers and scientists for centuries. Sensory-evoked activity patterns, memory engrams and internally generated brain activity conveying the animals internal state are meant to integrate to promote an appropriate behaviour. Still, direct evidence for how integration works on the network, the neurophysiological and the molecular level remains limited. Exemplifying internal needs with tiredness and hunger,",{"id":991,"funder":7,"programme":8,"title":992,"piName":10,"institution":993,"country":12,"year":13,"amount":994,"abstract":995},"cordis-european-research-council-award-101083647","Medical Image Analysis with Normative Machine Learning","FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG","€1,997,841","As one of the most important aspects of diagnosis, treatment planning, treatment delivery, and follow-up, medical imaging provides an unmatched ability to identify disease with high accuracy. As a result of its success, referrals for imaging examinations have increased significantly. However, medical imaging depends on interpretation by highly specialised clinical experts and is thus rarely available at the front-line-of-care, for patient triage, or for frequent follow-ups. Very often, excluding",{"id":997,"funder":7,"programme":8,"title":998,"piName":10,"institution":568,"country":12,"year":13,"amount":999,"abstract":1000},"cordis-european-research-council-award-101088594","Trustworthy AI tools for personalized oncology","€1,999,225","Modern machine learning algorithms have the potential to accelerate personalized medicine in a fast pace. To date, first tasks in medicine are being addressed with machine learning algorithms that surpass humans in terms of accuracy and speed, including diagnosis, outcome prediction and treatment recommendation.  However, for a widespread adoption in clinical practice, a good performance in terms of speed and accuracy is not sufficient: practitioners also need to be able to trust a models predic",{"id":1002,"funder":7,"programme":8,"title":1003,"piName":10,"institution":779,"country":139,"year":13,"amount":1004,"abstract":1005},"cordis-european-research-council-award-101088581","Role of epistatic interactions in evolution","€1,970,533","The distribution of fitness effects of mutations is vital to our understanding of rates and patterns of adaptation. Population genetics and mutation accumulation experiments have given us insight into the distribution of fitness effects of single mutations. However, mutations often interact with each other. This is called epistasis. The role of epistatic interactions in adaptation has remained controversial. Yet, the distribution of epistatic effects is as fundamental as distribution of mutation",{"id":1007,"funder":7,"programme":8,"title":1008,"piName":10,"institution":1009,"country":225,"year":13,"amount":1010,"abstract":1011},"cordis-european-research-council-award-101087802","Exploring Natural Immunity in Retinal Neovascular Disease","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","€1,999,681","Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the world. The number of people with AMD has reached 196 million, with ~1 in 10 people over 55 years already showing early signs of the condition. 70% of those who progress to late-stage disease will develop neovascular (nv)AMD due to uncontrolled growth of blood vessels behind the retina. In fact, aberrant growth of retinal or choroidal vasculature is a hallmark of diabetic retinopathy and nvAMD. Collective",{"id":1013,"funder":7,"programme":8,"title":1014,"piName":10,"institution":1015,"country":126,"year":13,"amount":1016,"abstract":1017},"cordis-european-research-council-award-101088763","DEep COgnition Learning for LAnguage GEneration","INSTITUTO DE TELECOMUNICACOES","€1,999,595","In recent years, transformer-based deep learning models such as BERT or GPT-3 have led to impressive results in many natural language processing (NLP) tasks, exhibiting transfer and few-shot learning capabilities.However, despite faring well in benchmarks, current deep learning models for NLP often fail badly in the wild: they are bad at out-of-domain generalization, they do not exploit contextual information, they are poorly calibrated, and their memory is not traceable. These limitations stem ",{"id":1019,"funder":7,"programme":8,"title":1020,"piName":10,"institution":260,"country":89,"year":13,"amount":28,"abstract":1021},"cordis-european-research-council-award-101088365","Immune Synapse Engagement as a Novel Approach for Cancer Immunotherapy","Monoclonal antibodies (mAbs) targeting immune checkpoints have revolutionized cancer treatment but exhibit several challenges, most notably, limited intratumor efficacy and relatively low patient response rates. Endowing these mAbs with immune-cell-recruitment capabilities may offer the solution to these drawbacks. This assumption is based on our recent findings that the effectivity of a given checkpoint mAb relies not only on its binding to its target T-cells receptor but also on the direct int",{"id":1023,"funder":7,"programme":8,"title":1024,"piName":10,"institution":1025,"country":12,"year":13,"amount":28,"abstract":1026},"cordis-european-research-council-award-101088965","Late life-applicable enhancement of longevity and fitness.","LEIBNIZ-INSTITUT FUR ALTERNSFORSCHUNG - FRITZ-LIPMANN-INSTITUT EV (FLI) LEIBNIZ INSTITUTE ON AGING - FRITZ LIPMANN INSTITUTE EV (FLI)","Aging represents gradual organismal decline driven by accumulation of cellular and molecular damages including DNA damage and metabolic failures. At young and middle age, these damages are mitigated by tailored repair systems, such as autophagy and DNA damage response. The repairs can be triggered through adaptive stress responses induced by anti-aging interventions such as dietary restriction (DR) and DR mimetic metformin. Recently, we found that loss of metabolic plasticity and repair activiti",{"id":1028,"funder":7,"programme":8,"title":1029,"piName":10,"institution":266,"country":89,"year":13,"amount":10,"abstract":1030},"cordis-european-research-council-award-101088962","Ships Harbouring in Ports","Until the emergence of the modern container ship, vessels spent a significant part of their lifespan in a harbour. The time period when a ship sets anchor in a harbour is key as the entire harbour was designed to offer mooring and all the facilities required for her stay. Yet, a harbour was not merely the accumulation of standings structures made of stone, concrete, or wood that helped ships make fast in Roman harbours. Associated activities extended beyond their principal basin, taking place on",{"id":1032,"funder":7,"programme":8,"title":1033,"piName":10,"institution":642,"country":165,"year":13,"amount":1034,"abstract":1035},"cordis-european-research-council-award-101088331","Orientation-Patterned Gallium Phosphide for Integrated Nonlinear Photonics","€1,880,000","Nonlinear optics is a thriving research field with numerous practical applications in advanced laser sources, all-optical frequency conversion, optical computing, generation of entangled pairs and quantum cryptography, supercontinuum and terahertz-radiation generation. Traditionally reserved to bulk, tabletop optical systems increasing drive in the photonics community to scale these applications to fit on a chip. The main bottleneck in the convergence of nonlinear optics and integrated photonics",{"id":1037,"funder":7,"programme":8,"title":1038,"piName":10,"institution":158,"country":12,"year":13,"amount":28,"abstract":1039},"cordis-european-research-council-award-101085894","Vesicular mechanisms of carbon fixation in calcifying cells of marine animals","The process of biomineralization has profound impacts on the geology of our planet and is an integral part of the global carbon cycle by generating large amounts of CaCO3 bound in coral reefs, chalk mountains and deep sea sediments. Mounting evidence demonstrate that many marine calcifiers generate biominerals by the intracellular formation of CaCO3 from seawater Ca2+ and metabolic CO2. To date, the underlying mechanisms that control the carbonate chemistry in calcifying vesicles are unknown whi",{"id":1041,"funder":7,"programme":8,"title":1042,"piName":10,"institution":1043,"country":20,"year":13,"amount":1044,"abstract":1045},"cordis-european-research-council-award-101087514","Swarming supramolecular robots","FUNDACION IMDEA NANOCIENCIA","€2,871,250","Biological robots perform complex biological functions such as cell division. Microtubule-asters, for example, use extendable legs emanating from a central point to position themselves at the center of the cell or to mechanically pull chromosomes apart. Their legs are formed by dissipative supramolecular polymerization of tubulin dimers into microtubules, powered by guanosine triphosphate chemical fuel. This Suprabot ERC-CoG proposal aims to make fully synthetic analogous of the microtubule-aste",{"id":1047,"funder":7,"programme":8,"title":1048,"piName":10,"institution":738,"country":34,"year":13,"amount":28,"abstract":1049},"cordis-european-research-council-award-101089334","Advanced X-ray Energy-sensitive  Microscopy for Virtual Histology","In the last 20 years, phase-contrast x-ray imaging has evolved from first proof-of-principle experiments with relatively poor contrast, to a mature research field with many branches. Standing on the shoulders of scientific achievements and technological development, the time has come where virtual histology for biomedical applications is within reach. The aim of this research project is to design and construct a prototype x-ray microscope for three-dimensional histology.In the clinics we are use",{"id":1051,"funder":7,"programme":8,"title":1052,"piName":10,"institution":816,"country":82,"year":13,"amount":1053,"abstract":1054},"cordis-european-research-council-award-101088156","Towards an evidence-based model for big data policing: Evaluating the statistical-methodological, criminological and legal and ethical conditions","€1,972,500","Big data policing is an innovative strategy that uses historical data to forecast when and where there is a high risk of new crime events in order to use police resources more efficiently and proactively, and ultimately reduce crime rates. Big data policing models can consist of variables based on crime data available in police databases (e.g. previous crime events), socio-economic data (e.g. poverty index, residential mobility), opportunity characteristics (e.g. the presence of shops, distance ",{"id":1056,"funder":7,"programme":8,"title":1057,"piName":10,"institution":1058,"country":12,"year":13,"amount":1059,"abstract":1060},"cordis-european-research-council-award-101044469","Deciphering the Regulatory Logic of Cortical Development","HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH","€1,999,643","The mammalian cortex is the most complex region of the brain responsible for higher cognitive functions. Abnormal cortical development often translates into prominent neuropsychiatric diseases, which affect different neuronal subtypes with unique molecular and morphological features. Increasing evidence suggests that epigenetic regulation is essential for cortical development but how multiple regulatory layers are coordinated to specify distinct neuronal lineages in vivo remains unclear.My team ",{"id":1062,"funder":7,"programme":8,"title":1063,"piName":10,"institution":402,"country":108,"year":13,"amount":1064,"abstract":1065},"cordis-european-research-council-award-101086998","VULCAN: matter, powered from within","€1,965,025","Vulcan, the Roman god of blacksmithing, was revered in Europe since the Iron Age (1200-500 BC) for a powerful skill: controlling the macroscopic properties of metals (strength, ductility, toughness). To this day, thermal treatments such as annealing - cycles of high temperatures, alternated with slow cooling - remain an essential tool of material science. However, Vulcans traditional powers forge monolithic, static, and passive materials, and are laughably blunt instruments when compared to livi",{"id":1067,"funder":7,"programme":8,"title":1068,"piName":10,"institution":500,"country":41,"year":13,"amount":1069,"abstract":1070},"cordis-european-research-council-award-101088489","Women and Non-Alignment in the Cold War era: biographical and intersectional perspectives","€1,985,458","WO-NAM will provide crucial insights into the history of women’s participation in the Non-Aligned Movement during the Cold War era, studying the roles of female leaders, women’s movements and women’s organizations. It will redefine existing interpretations of Cold War history and historiography by conducting groundbreaking research on the significance of Non-Aligned networks in shaping transnational debates on women’s rights within international institutions. Bringing together women’s and gender",{"id":1072,"funder":7,"programme":8,"title":1073,"piName":10,"institution":1074,"country":82,"year":13,"amount":1075,"abstract":1076},"cordis-european-research-council-award-101088316","Deciphering the nanobiophysics of virus-host interactions in 3D cellular systems","UNIVERSITE CATHOLIQUE DE LOUVAIN","€2,867,346","The current pandemic demonstrates how viruses represent a major threat for human health. Viral infection is a complex multistep process involving both the virus and the host cell machinery. The very first stage consists of landing and binding of the virus, followed by host cell entry, and then the release of the viral genetic material into the cell. Entry pathways are largely defined by the preliminary interactions between viruses and their receptors at the cell interface. Elucidating this compl",{"id":1078,"funder":7,"programme":8,"title":1079,"piName":10,"institution":224,"country":225,"year":13,"amount":1080,"abstract":1081},"cordis-european-research-council-award-101088497","Systems of Transmitting Early Modern Manuscript Verse, 1475–1700","€1,864,593","STEMMA offers the first large-scale quantitative analysis of the circulation of early modern English poetry in manuscript between 1475 and 1700. It addresses a significant gap by developing innovative computational methods for studying the social and material forces that informed literary culture. Scholars have tended to address individual manuscripts as case studies. In contrast, STEMMA revolutionizes the study of manuscript poetry by taking a data-driven approach to identify patterns and trend",{"id":1083,"funder":7,"programme":8,"title":1084,"piName":10,"institution":288,"country":27,"year":13,"amount":1085,"abstract":1086},"cordis-european-research-council-award-101088673","Shaping the future – From spermatids to spermatozoa","€1,999,963","Sperm are highly specialised cells whose structure is optimised for a defined function. Although the distinctive sperm ultrastructure has been known for many years thanks to electron microscopy, an understanding of the molecular details of sperm specialisation is severely lagging. The gap in our molecular understanding relates to the difficulties in genetically manipulating sperm. Over the past five years, my lab has pioneered the use of cryo-electron tomography to study mature mammalian sperm a",{"id":1088,"funder":7,"programme":8,"title":1089,"piName":10,"institution":195,"country":27,"year":13,"amount":1090,"abstract":1091},"cordis-european-research-council-award-101089113","The Religious Politics of Theme Parks in the 21st century: Imagineering Religion, Heritage and National Sentiments","€1,996,729","Why do religious theme parks appear in secular countries? MAKEBELIEF investigates how in the 21th century, immersive media are mobilized to 'imagineer' religion. The project provides a comparative analysis of religious theme parks in China, Turkey the Netherlands and the United States. MAKEBELIEF investigates religious theme parks on three levels: Firstly this project analyses through documentary analysis why religious organizations, heritage institutions, government agencies and corporations in",{"id":1093,"funder":7,"programme":8,"title":1094,"piName":10,"institution":1009,"country":225,"year":13,"amount":1095,"abstract":1096},"cordis-european-research-council-award-101088193","Finding All Integrable Models","€1,994,849","Symmetry plays an important role in our current understanding of nature. For instance, in the development of the Standard Model of particle physics the understanding of the gauge group of symmetries was crucial. There is a class of models, called integrable systems, which have so many symmetries that they are exactly solvable. Such models have the exciting possibility to be understood in all aspects and thus give valuable insights into physical phenomena. In this way integrable models offer a un",{"id":1098,"funder":7,"programme":8,"title":1099,"piName":10,"institution":1100,"country":1101,"year":13,"amount":1102,"abstract":1103},"cordis-european-research-council-award-101087964","PAST & FUTURE MILLET FOODWAYS","VILNIAUS UNIVERSITETAS","LT","€1,999,489","Crop diversification critically mitigates agricultural risk for humanity. Identifying the environmental and cultural factors influencing the adoption and abandonment of staple foods through time is essential to an informed discussion about present-day food security and adaptation to a changing global climate. Past studies on ancient agriculture have identified the routes and timing of primary crop dispersals, but we possess a remarkably narrow understanding on how and why new foods were integrat",{"id":1105,"funder":7,"programme":8,"title":1106,"piName":10,"institution":642,"country":165,"year":13,"amount":1107,"abstract":1108},"cordis-european-research-council-award-101087562","Light elements in irons and metal-rich meteorites: Their isotopic distribution and evolution in the protoplanetary disk","€1,779,805","Knowledge of the light element (H, C, N) characteristics of planetary building blocks is key to our understanding of the development of habitable conditions on Earth. Since 'magmatic' iron meteorites originate from the metallic cores of the earliest, differentiated planetesimals, they may preserve a record of H, C, and N isotopic variations in the inner and outer solar system during the first stages of planetary accretion. Based on novel multi-light-element isotopic analyses of irons and other F",{"id":1110,"funder":7,"programme":8,"title":1111,"piName":10,"institution":642,"country":165,"year":13,"amount":1112,"abstract":1113},"cordis-european-research-council-award-101089040","Terahertz Ultra Strong Coupling  for mAcromolecules structure aNalYse & control","€1,999,555","MacroMolecules (e.g Proteins, DNA) carry out most of the functions of the living and these functions come from their 3D-structure. For instance, foldopathy like Alzheimers and Parkinsons disease are caused by misfolding of proteins. Modifying this structure non-invasively is consequently a tremendous challenge for both microbiology research and applications.Besides, light-Matter strong coupling (SC) occurs when a material is located at a high density of state of a photonic mode resonant with one",{"id":1115,"funder":7,"programme":8,"title":1116,"piName":10,"institution":642,"country":165,"year":13,"amount":860,"abstract":1117},"cordis-european-research-council-award-101088091","Paleo-MARE: a paleoecological approach to deciphering the impact of heavy metals on antibiotic resistance spread in the environment","Global biogeochemical cycles drive our planets health through the control of microbial habitats, nutrient availability and distribution, and exposure to reactive chemicals. By releasing heavy metals into the environment and altering natural fluxes, Humans have carried out a planetary wide experiment for millennia that is pushing our ecosystem towards an unknown future. More recently, this has included the production, use and release of antibiotics, which has led to the spread of antibiotic resis",200,{"programme":8,"total":1120,"withPiName":1121,"firstYear":1122,"lastYear":1123,"countryCount":1124,"perYear":1125,"topInstitutions":1165,"topCountries":1234},4499,349,2014,2027,45,[1126,1128,1131,1134,1137,1140,1143,1146,1149,1152,1154,1157,1160,1163],{"year":1122,"count":1127},303,{"year":1129,"count":1130},2015,335,{"year":1132,"count":1133},2016,322,{"year":1135,"count":1136},2017,327,{"year":1138,"count":1139},2018,403,{"year":1141,"count":1142},2019,300,{"year":1144,"count":1145},2020,277,{"year":1147,"count":1148},2021,321,{"year":1150,"count":1151},2022,364,{"year":13,"count":1153},359,{"year":1155,"count":1156},2024,366,{"year":1158,"count":1159},2025,375,{"year":1161,"count":1162},2026,416,{"year":1123,"count":1164},31,[1166,1169,1172,1175,1178,1181,1184,1186,1188,1191,1193,1196,1199,1201,1203,1206,1209,1212,1215,1218,1220,1223,1226,1229,1232],{"name":1167,"count":1168},"Centre National de la Recherche Scientifique CNRS",229,{"name":1170,"count":1171},"University of Oxford",89,{"name":1173,"count":1174},"Weizmann Institute of Science",78,{"name":1176,"count":1177},"University of Cambridge",77,{"name":1179,"count":1180},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",63,{"name":1182,"count":1183},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",55,{"name":1185,"count":1183},"Institut National de la Sante Et de la Recherche Medicale",{"name":1187,"count":1183},"Kobenhavns Universitet",{"name":1189,"count":1190},"Universiteit Utrecht",51,{"name":1192,"count":1190},"University College London",{"name":1194,"count":1195},"Tel Aviv University",49,{"name":1197,"count":1198},"The Hebrew University of Jerusalem",43,{"name":1200,"count":1198},"Universiteit Gent",{"name":1202,"count":1198},"Universiteit van Amsterdam",{"name":1204,"count":1205},"Ludwig-Maximilians-Universitaet Muenchen",42,{"name":1207,"count":1208},"Technische Universitaet Muenchen",41,{"name":1210,"count":1211},"Eidgenoessische Technische Hochschule Zuerich",40,{"name":1213,"count":1214},"Universitat Wien",39,{"name":1216,"count":1217},"Helsingin Yliopisto",38,{"name":1219,"count":1217},"Technische Universiteit Delft",{"name":1221,"count":1222},"Katholieke Universiteit Leuven",37,{"name":1224,"count":1225},"Universitetet I Oslo",36,{"name":1227,"count":1228},"École Polytechnique Fédérale de Lausanne",34,{"name":1230,"count":1231},"The University of Edinburgh",32,{"name":1233,"count":1164},"Lunds Universitet",[1235,1237,1240,1242,1244,1246,1248,1250,1252,1254,1256,1258,1260,1262,1264,1266,1268,1271,1272,1275,1278,1281,1284,1286,1289],{"name":12,"count":1236},810,{"name":1238,"count":1239},"UK",559,{"name":165,"count":1241},490,{"name":27,"count":1243},428,{"name":20,"count":1245},315,{"name":41,"count":1247},267,{"name":89,"count":1249},219,{"name":1251,"count":1118},"CH",{"name":34,"count":1253},170,{"name":82,"count":1255},166,{"name":108,"count":1257},146,{"name":207,"count":1259},127,{"name":139,"count":1261},94,{"name":178,"count":1263},85,{"name":225,"count":1265},82,{"name":126,"count":1267},68,{"name":1269,"count":1270},"GB",47,{"name":146,"count":1225},{"name":1273,"count":1274},"HU",24,{"name":1276,"count":1277},"EL",22,{"name":1279,"count":1280},"US",21,{"name":1282,"count":1283},"PL",20,{"name":396,"count":1285},14,{"name":1287,"count":1288},"LU",13,{"name":1290,"count":1291},"EE",8]