[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-consolidator-grant-2024":3,"awarded-stats-erc-consolidator-grant":1112},{"awarded":4,"total":1111},[5,16,23,30,36,43,50,56,62,68,73,79,86,91,97,101,107,114,120,126,131,138,143,149,155,162,168,174,179,185,191,197,202,208,214,218,224,231,237,242,248,253,259,265,270,275,281,288,293,299,305,310,315,321,327,332,337,343,349,355,361,366,372,378,385,389,395,401,407,413,419,425,430,436,441,448,454,460,466,472,478,483,489,493,498,503,509,516,522,528,533,539,544,550,554,560,565,569,575,580,585,591,598,603,609,614,620,625,630,634,640,646,652,657,663,669,674,679,683,688,693,697,702,706,712,718,723,729,734,740,745,751,756,760,765,770,775,780,785,789,794,800,805,811,816,821,826,830,836,842,847,852,857,862,867,873,879,885,891,896,901,906,911,917,921,927,933,939,944,949,955,960,965,969,974,980,985,991,995,1000,1005,1011,1016,1021,1027,1033,1039,1044,1048,1053,1059,1065,1071,1076,1080,1086,1091,1096,1101,1106],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-101125172","European Research Council","ERC Consolidator Grant","Holographic Optical Tweezing Bioprinting (HOTB): Towards precise manipulation of cells for artificial multi-scaled vascularized tissues\u002Forgan printing.",null,"UNIVERSIDADE DA CORUNA","ES",2024,"€1,965,525","Because current limitations in 3D bioprinting for tissue engineering stem from the fact that the multi-scaled vasculature associated to the human microtissues and organs cannot be replicated.  The overarching aim of the HOT-BIOPRINTING project is to deliver a methodology enabling the manufacturing of a new generation of tissue-like structures with properties mimicking more closely the complexity of biological tissues and organs. The innovation of HOT-BIOPRINTING lies on the development of a disr",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":20,"year":13,"amount":21,"abstract":22},"cordis-european-research-council-award-101124273","Portal Range Monitoring in Mixed Ion Beam Surgery","GSI HELMHOLTZZENTRUM FUR SCHWERIONENFORSCHUNG GMBH","DE","€2,000,000","Half of the approximately 4 million annual cancer cases in Europe receive radiotherapy. While many cancer patients have benefitted from technical improvements in recent years, widespread diseases, such as pancreatic and lung cancer, still have dismally low cure rates, with median survival of less than 2 years. Carbon ion radiotherapy (CIRT) offers unprecedented precision in delivering tumour dose, and can be the much needed game changer for these patients. However, CIRT is vulnerable to uncertai",{"id":24,"funder":7,"programme":8,"title":25,"piName":10,"institution":26,"country":27,"year":13,"amount":28,"abstract":29},"cordis-european-research-council-award-101124948","Novel light regimes and drought effects on temperate forest plant biodiversity","UNIVERSITEIT GENT","BE","€1,999,094","Tree canopies are one of the most recognizable features of forests, providing shelter from external influences to a myriad of species that live in the understorey. Canopy disturbances are now accelerating across European forests, and climate-change induced drought is a key driver. These disturbances are opening the canopy and exposing forest biodiversity to no-analog light regimes and drought – light and drought levels they have never been exposed to before. As the majority of forest plant speci",{"id":31,"funder":7,"programme":8,"title":32,"piName":10,"institution":33,"country":20,"year":13,"amount":34,"abstract":35},"cordis-european-research-council-award-101125948","Photonic metasurfaces for resource-efficient ultrathin high efficiency tandem solar cells","ALBERT-LUDWIGS-UNIVERSITAET FREIBURG","€2,676,875","The transition towards a society based on 100% renewable energy requires massive deployment of photovoltaics of 30-70 TW until 2050. This requires huge amounts of resources, while their limited availability is already becoming apparent. A major lever to reduce resource consumption is to increase the solar cell efficiency. As best single junction solar cells approach their fundamental limits, higher efficiency can only be reached with so-called tandem solar cells, made of two or more subcells. Al",{"id":37,"funder":7,"programme":8,"title":38,"piName":10,"institution":39,"country":40,"year":13,"amount":41,"abstract":42},"cordis-european-research-council-award-101125807","Tidal Disruption Events: A New Black Hole Census","THE HEBREW UNIVERSITY OF JERUSALEM","IL","€1,998,750","Massive black holes (MBHs) are key players in high energy astrophysics, galaxy formation and evolution, and astroparticle physics. Despite their centrality to astronomy, we still cannot answer basic questions about MBHs. What are their origins? How have they grown over cosmic time? What are their current demographics? To answer these questions, the project will turn tidal disruption events (TDEs) from curiosities into reliable probes of MBH parameters. A TDE occurs when an unlucky star passes to",{"id":44,"funder":7,"programme":8,"title":45,"piName":10,"institution":46,"country":47,"year":13,"amount":48,"abstract":49},"cordis-european-research-council-award-101126073","The Interplay of Aging, Immune Signaling and Stem Cell Function","FUNDACAO GIMM - GULBENKIAN INSTITUTE FOR MOLECULAR MEDICINE","PT","€1,998,843","Adult stem cells (SCs) sustain tissue renewal and repair throughout life. The SC niche is fundamental in the regulation of SC function and an important contributor to SC decline in aging. While alterations in the tissue’s immune environment are emerging as important contributors to impairments found in aged organs, their contribution to SC dysfunction in aging is unknown. The skeletal muscle (SkM) is a paradigmatic model to study age-related loss of repair capacity. Muscle stem cell (MuSC) funct",{"id":51,"funder":7,"programme":8,"title":52,"piName":10,"institution":53,"country":20,"year":13,"amount":54,"abstract":55},"cordis-european-research-council-award-101125081","Hydrogel Machines for Seamless Living System Interfaces","LEIBNIZ-INSTITUT FUR POLYMERFORSCHUNG DRESDEN EV","€1,999,473","Bioelectronic interfaces are machines designed to exchange information with living matter. They are opening new frontiers in medicine. For example, machines implanted in the body may soon enable repair of damaged tissues or replacement of functions affected by chronic disease. The realisation of this vision is impeded by the available hardware. Today’s materials, devices and systems are electronic, while soft living matter uses ions and molecules for communication and computation. The central hy",{"id":57,"funder":7,"programme":8,"title":58,"piName":10,"institution":59,"country":20,"year":13,"amount":60,"abstract":61},"cordis-european-research-council-award-101124463","Generalised Time-Separated Stochastic Mechanics","GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER","€1,996,920","As a physical fact, randomness is an inherent and ineliminable aspect in all physical measurements and engineering production. Hence, all material parameters are subject to stochastic fluctuations. However, highly accurate predictions are key to achieving the goals of resource-efficiency and sustainability in engineering and construction. In this context, randomness in material parameters constitutes a severe problem: if we can experimentally quantify the magnitude of fluctuations of material pa",{"id":63,"funder":7,"programme":8,"title":64,"piName":10,"institution":65,"country":40,"year":13,"amount":66,"abstract":67},"cordis-european-research-council-award-101123661","An individual-specific understanding of how synchrony becomes curative","UNIVERSITY OF HAIFA","€2,122,524","Human beings constantly go in and out interpersonal interactions in their daily lives; these interactions are assumed to have critical effects on mental health. But how such interactions affect mental health is poorly understood. SynSig suggests that interpersonal synchrony is an individual-specific mechanism underlying curative relationships. It seeks to go beyond the one-size-fits-all “the higher the synchrony the better” theoretical assumption underlying the state of the art research. It is t",{"id":69,"funder":7,"programme":8,"title":70,"piName":10,"institution":26,"country":27,"year":13,"amount":71,"abstract":72},"cordis-european-research-council-award-101045786","Polymathy and Interdisciplinarity in Premodern Islamic Epistemic Cultures","€1,996,396","KNOW is the first comprehensive study of polymathy and interdisciplinarity in premodern Islam. The project sets out to write a history of knowledge that takes the interaction between disciplines as its primary subject. The project’s historical framework is the post-formative period, 1200-1800 CE, which saw the rise of new institutions of learning, the proliferation of libraries, the formation and integration of disciplines and curricular texts, and an increase in academic travel, facilitating in",{"id":74,"funder":7,"programme":8,"title":75,"piName":10,"institution":76,"country":20,"year":13,"amount":77,"abstract":78},"cordis-european-research-council-award-101122174","Understanding Trajectories of Wealth Accumulation and Their Variability","DEUTSCHES INSTITUT FUR WIRTSCHAFTSFORSCHUNG DIW (INSTITUT FUR KONJUNKTURFORSCHUNG) EV","€1,992,264","WEALTHTRAJECT is the first project to comprehensively and systematically examine diversity in long-term trajectories of wealth accumulation within and between social groups.Wealth inequality is on the rise in many affluent societies. It is time to move beyond prevailing static snapshots of average wealth inequality between people to understand this trend. Instead, a dynamic perspective on wealth changes experienced by people over their lifetimes is needed. This dynamic perspective reveals how di",{"id":80,"funder":7,"programme":8,"title":81,"piName":10,"institution":82,"country":83,"year":13,"amount":84,"abstract":85},"cordis-european-research-council-award-101125162","Kinetic Limits of Many-Body Classical Systems","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","IT","€1,396,400","This project studies the transition between dynamical laws governing the physical world at different scales. Our focus will be on large systems of interacting particles with random initial data, underlying the kinetic theory of gases and dilute plasmas. Central to this theory are the Boltzmann equation, and its appropriate modification for charged particles given by Landau. Their description of approach to equilibrium and irreversible behaviour is a legendary success in the physics of time-depen",{"id":87,"funder":7,"programme":8,"title":88,"piName":10,"institution":89,"country":12,"year":13,"amount":21,"abstract":90},"cordis-european-research-council-award-101124884","Tackling Water Theft: Forecasting Adaptation Surprises","FUNDACION IMDEA AGUA","Water theft claims between 30% and 50% of the global water supply, and despite policy efforts to tackle it, is still on the rise. The policy failure to tackle water theft has been attributed to the nonlinear adaptive responses by economic agents such as irrigators, which can affect and be affected by other socioeconomic (e.g., growing crop prices) and ecological processes (e.g., water scarcity) via feedback loops with cascading impacts that are difficult to foresee. This has led to adaptation su",{"id":92,"funder":7,"programme":8,"title":93,"piName":10,"institution":94,"country":95,"year":13,"amount":21,"abstract":96},"cordis-european-research-council-award-101124815","Unlocking the Complexities of Wind Farm-Atmosphere Interaction: A Multi-Scale Approach","UNIVERSITEIT TWENTE","NL","Turbulence drives transport processes in the atmosphere and determines Earth’s weather and climate. Wind farm performance depends on atmospheric turbulence as it entrains energy into wind turbine arrays. As wind turbines and farms expand in size, they increasingly interact with an unexplored atmospheric region and large-scale weather phenomena in ways that are not fully understood. Typical wind farm simulations assume idealized cases and do not capture the influence of (i) dynamic changes in atm",{"id":98,"funder":7,"programme":8,"title":99,"piName":10,"institution":94,"country":95,"year":13,"amount":21,"abstract":100},"cordis-european-research-council-award-101124751","From A to B: Generalizing the mathematics of artificial neural networks (ANNs) to biological neural networks (BNNs)","Why does the brain outperform AI? Artificial neural networks (ANNs) are at the core of the AI revolution. In the past years, enormous efforts have been made to unravel their mathematical properties, leading to fundamental insights and mathematical guarantees on when and why deep learning works well. ANNs are inspired by biological neural networks (BNNs) but differ in many respects: ANNs represent functions while BNNs represent stochastic processes, and the gradient-based deep learning applied fo",{"id":102,"funder":7,"programme":8,"title":103,"piName":10,"institution":104,"country":95,"year":13,"amount":105,"abstract":106},"cordis-european-research-council-award-101126217","Gravitational Physics from the Universe Large Scales Evolution","UNIVERSITEIT LEIDEN","€1,999,219","How does gravity work on cosmological scales? Starting from July 2023, for the very first time in the history of space science, the geometry of the Universe Large Scales will be mapped by the Euclid mission, providing the scientific community with a wealth of cosmological data of unprecedented quantity and quality. It will be a transformational moment that will open a new ground for testing gravity; yet, unless combined with a theoretical framework able to translate wonderful numbers into concep",{"id":108,"funder":7,"programme":8,"title":109,"piName":10,"institution":110,"country":111,"year":13,"amount":112,"abstract":113},"cordis-european-research-council-award-101124514","Intermetallic Phase Heterostructured Circular Aluminium Alloys","MONTANUNIVERSITAET LEOBEN","AT","€1,999,989","A tenet in metallurgy is that the purer metals and alloys are, the better are their properties. However, as recycling in material production increases in importance, so do impurity levels. In aluminium the consequences are particularly harmful because the solubility of most elements in aluminium is very small, resulting in the formation of brittle intermetallic phases. Moreover, once impurities have entered aluminium, it is nearly impossible to remove them. The HETEROCIRCAL project aims to break",{"id":115,"funder":7,"programme":8,"title":116,"piName":10,"institution":117,"country":20,"year":13,"amount":118,"abstract":119},"cordis-european-research-council-award-101124323","Intimate Dispossession: The Afterlives of Plundered Jewish Personal Possessions in the Aftermath of the Holocaust","HUMBOLDT-UNIVERSITAET ZU BERLIN","€1,999,888","This project aims to write the history of the great plunder of small thingseveryday household objects, and personal items, including clothing, looted on a mass-scale by local non-Jews during, and in the aftermath of, the Holocaust. While historical research has focused on the top-down and centralized Nazi states takeover of Jewish financial assets, real estate, businesses, or art objects, we know nothing about the afterlives of unmarked objects of daily use that changed hands in the course of th",{"id":121,"funder":7,"programme":8,"title":122,"piName":10,"institution":123,"country":124,"year":13,"amount":21,"abstract":125},"cordis-european-research-council-award-101125009","Icevoltaics: from the Workman-Reynolds Freezing Potentials to Electrical Energy","NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU","NO","Water and aqueous solutions release a huge amount of thermal energy during freezing. Accessing energy utilizing the freezing process has never been attempted until today. It is known that orderly freezing of dilute aqueous solutions can result in electrical potentials as great as 230 volts at the ice-solution interface, namely the Workman-Reynolds freezing potential (WRFP), and a maximal electrical current of 1 µA. Based on our newly published results of counter ion separation during icing growt",{"id":127,"funder":7,"programme":8,"title":128,"piName":10,"institution":129,"country":111,"year":13,"amount":10,"abstract":130},"cordis-european-research-council-award-101123203","Celtic and Latin glossing traditions: uncovering early medieval language contact and knowledge transfer","UNIVERSITAET GRAZ","Glosses are fingerprints of the society in which texts were composed, copied, and read. Most importantly, they play a much more significant role than previous research has acknowledged and offer insights about the multilingual and multi-ethnic environment of medieval manuscript and text production the principal texts cannot: they are first-hand testimonies of the close linguistic and cultural contacts between Insular Celtic (Old Breton, Old Irish, Old Welsh) and Latin speakers. GLOSSIT researche",{"id":132,"funder":7,"programme":8,"title":133,"piName":10,"institution":134,"country":135,"year":13,"amount":136,"abstract":137},"cordis-european-research-council-award-101125118","Arousal and respiratory co-dysfunction in drug-resistant epilepsy: from mechanisms to therapy","UNIVERSITE LYON 1 CLAUDE BERNARD","FR","€1,994,315","Both seizures and their complications are modulated by patients’ vigilance states. Several epilepsy complications are associated with sleep, including Sudden and Unexpected Death in Epilepsy (SUDEP). SUDEP primarily results from a fatal postictal central apnea after a nocturnal generalized convulsive seizures. While transient seizure-related respiratory dysfunction is frequent in patients, current hypotheses suggest that in some of them, repetition of seizures may induce a chronic alteration of ",{"id":139,"funder":7,"programme":8,"title":140,"piName":10,"institution":26,"country":27,"year":13,"amount":141,"abstract":142},"cordis-european-research-council-award-101125822","Probing Gauge Symmetries and \u2028Gauge-Matter Interactions \u2028using Tensor Networks","€1,997,500","We are in the midst of the second quantum revolution. Highly entangled quantum matter is being discovered, engineered, controlled and probed across a wide range of scales and conditions; quantum platforms are being used to emulate other quantum systems. The ability to simulate the quantum world on classical computers has been instrumental in guiding, validating and diagnosing these exciting developments. As the quantum world is probed beyond regimes of weak coupling and near-equilibrium, novel c",{"id":144,"funder":7,"programme":8,"title":145,"piName":10,"institution":146,"country":20,"year":13,"amount":147,"abstract":148},"cordis-european-research-council-award-101124282","Early Build-up of Ringed Planet-Forming Disks","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€1,999,250","With one planet per star on average, planet formation must be a robust process. Yet, surprisingly, we still do not fully understand how planet formation works. Current models for planet formation usually assume pre-existing smooth disks and homogeneously distributed planetesimals of arbitrary composition. In contrast, recent results highlight the crucial role of early stage disk sub-structure, inhomogeneous accretion, and carbon depletion processes on the final planetary systems. Until now, adeq",{"id":150,"funder":7,"programme":8,"title":151,"piName":10,"institution":152,"country":40,"year":13,"amount":153,"abstract":154},"cordis-european-research-council-award-101122583","Overcoming the sign problem in lattice gauge theories using tensor networks","TEL AVIV UNIVERSITY","€1,795,300","Tensor networks, and particularly projected entangled pair states (PEPS), are special quantum many-body states that describe strongly-correlated systems well due to their entanglement structure. They have been successfully applied in various scenarios and recently to lattice gauge theories (LGTs) where they outperformed conventional Monte-Carlo calculations and overcame the sign problem in some examples, but mostly in single-space dimensions due to limitations of tensor network methods. A fundam",{"id":156,"funder":7,"programme":8,"title":157,"piName":10,"institution":158,"country":159,"year":13,"amount":160,"abstract":161},"cordis-european-research-council-award-101125476","Creating water-smart landscapes","TARTU ULIKOOL","EE","€1,909,500","With the growing human population, the diffuse nutrient emissions from agriculture are expected to increase with the rise of fertilizer use. This situation has created a need for sustainable intensification by increasing yields while simultaneously decreasing the environmental impacts. Nature-based solutions (NbS) such as wetlands and riparian buffer strips can efficiently reduce the nutrient runoff from agricultural catchments. However, most land and water management studies mostly do not ident",{"id":163,"funder":7,"programme":8,"title":164,"piName":10,"institution":165,"country":12,"year":13,"amount":166,"abstract":167},"cordis-european-research-council-award-101125455","From wild to crop: unravelling the impact of root domestication on drought tolerance","INSTITUT DE RECERCA I TECNOLOGIA AGROALIMENTARIES","€1,999,141","Crop domestication revolutionised human life. This process induced changes in plant traits that produced plants that grew faster and generated higher yields. However, remarkably little is known about how plant roots have changed throughout the domestication process. Climate change is causing increasing droughts in many parts of the world. Given that roots are the way that water enters the plant, they are key for understanding drought tolerance. Root traits from crop ancestors could offer a route",{"id":169,"funder":7,"programme":8,"title":170,"piName":10,"institution":171,"country":83,"year":13,"amount":172,"abstract":173},"cordis-european-research-council-award-101124721","Epicuticular electrification: spontaneous charging of materials at the world's largest bio-air interface","SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA","€1,999,625","The materials on the outer plant surface create the world's largest bio-air interface. Invisibly, this surface spontaneously charges when hit by raindrops and solid materials. This is due to contact electrification, a phenomenon used in technologies like printing and energy harvesting. Yet, extraordinarily little is known about its role in nature and how biosurfaces charge.   EpiC will target two exciting and unresolved questions: a) can one exploit the generated charges to power high-tech devic",{"id":175,"funder":7,"programme":8,"title":176,"piName":10,"institution":177,"country":27,"year":13,"amount":10,"abstract":178},"cordis-european-research-council-award-101125625","High resolution dual comb spectroscopy and ranging","UNIVERSITE LIBRE DE BRUXELLES","Spectroscopy and metrology are amongst the most important applications of electromagnetic fieldsThe very fast oscillations of light (up to 200 THz in the infrared) permit very precise distance measurements as well as broadband analysis of radiations emitted and absorbed by matter.The technologies have evolved tremendously over the years and, at the turn of the century, a ground-breaking technology was proposed. By using two sources of optical pulse trains (corresponding to optical frequency comb",{"id":180,"funder":7,"programme":8,"title":181,"piName":10,"institution":182,"country":124,"year":13,"amount":183,"abstract":184},"cordis-european-research-council-award-101125376","Nitric oxide-driven anaerobic oxidation of lignocellulose","NORGES MILJO-OG BIOVITENSKAPELIGE UNIVERSITET","€1,999,858","In the riparian zone of eutrophic lakes and in field denitrification beds, microbial communities degrade lignocellulose, in anoxia, while maintaining a denitrifying lifestyle. During this process nitrate is converted to nitrogen gases via a series of reactions and intermediate products, fueled by the degradation of lignocellulosic biomass. The microbial interactions, metabolic pathways, and enzymatic mechanisms, underlining this remarkable process remain largely unknown. Intriguingly, in these a",{"id":186,"funder":7,"programme":8,"title":187,"piName":10,"institution":188,"country":95,"year":13,"amount":189,"abstract":190},"cordis-european-research-council-award-101122916","Large-scale conservation of perishable foodstuffs  in the Low Countries, 1600-1800","KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW","€1,997,168","In the early modern period, large-scale food conservation practices such as fermenting, smoking, and pickling were crucial for globalizing trade and increasing food security, and thus for economic and demographic growth in Europe’s cultural trading hubs. In addition, recent research indicates that domestic and trade practices like food conservation were key to the development of natural philosophical and chemical knowledge and vice versa. Yet we still know very little about how knowledge on earl",{"id":192,"funder":7,"programme":8,"title":193,"piName":10,"institution":194,"country":20,"year":13,"amount":195,"abstract":196},"cordis-european-research-council-award-101125530","Understanding mechanisms of Transcription Factor cooperativity across scales","EUROPEAN MOLECULAR BIOLOGY LABORATORY","€1,990,221","Transcription Factors (TFs) are critical regulators of many essential cellular functions such as the acquisition of cell identities in healthy tissues and their dysregulation in disease. Transcriptional activation of a gene typically requires the cooperative binding of multiple TFs, that subsequently recruit various additional cofactors. Genomics has enabled the generation of a near-complete annotation of the cis-regulatory elements and TFs binding them across cell types. Yet, the precise functi",{"id":198,"funder":7,"programme":8,"title":199,"piName":10,"institution":188,"country":95,"year":13,"amount":200,"abstract":201},"cordis-european-research-council-award-101125333","Voices of Resistance: A Global Micro-Historical Approach to Enslavement across the Atlantic and Indian Ocean","€1,999,999","Historiography suggests that the different ways in which people were enslaved (e.g. through war, kidnapping, debt, birth) mattered greatly for how they resisted and were treated under slavery. These links remain largely unexplored, but are vital to re-understanding the history and present of slavery. This project studies how responses to modes of enslavement impacted i) slave trade patterns, ii) labelling and treatment, and iii) strategies of enslaved across the Indian Ocean, Indonesian archipel",{"id":203,"funder":7,"programme":8,"title":204,"piName":10,"institution":205,"country":83,"year":13,"amount":206,"abstract":207},"cordis-european-research-council-award-101126304","No time for cosmology: Decoding dynamics from static cosmological correlations","SCUOLA NORMALE SUPERIORE","€1,610,469","The beginnings of the universe are encoded in the statistical properties of primordial perturbations imprinted at the hot Big Bang. Our understanding of primordial cosmology comes from measurements of these imprinted spatial correlations. They form a static pattern, and its apparent lack of causality is elegantly explained by an earlier period of time evolution. This time evolution from very primordial eras of the universe can not be observed directly. For conceptual and practical purposes, a re",{"id":209,"funder":7,"programme":8,"title":210,"piName":10,"institution":211,"country":95,"year":13,"amount":212,"abstract":213},"cordis-european-research-council-award-101126320","Where are the Humanities in the Medical Humanities? How Comics Can Improve Healthcare Training, Practice, and Dissemination","STICHTING VU","€1,979,844","The last decade has seen a steady increase in the number of medical schools offering courses in the Medical Humanities, an interdisciplinary field that promotes the study of the Humanities in healthcare education as engendering greater awareness in practitioners in training and thereby better healthcare practice and dissemination. While research in the field is rapidly developing, it problematically remains largely theoretical, based on a single case study, and\u002For presents Humanities scholarship",{"id":215,"funder":7,"programme":8,"title":216,"piName":10,"institution":33,"country":20,"year":13,"amount":21,"abstract":217},"cordis-european-research-council-award-101124519","Retelling and Repetition: Towards a Literary History of Derivation","Why are contemporary readers so fascinated by retellings of the Iliad or Beowulf? And why have retellings of premodern – ancient and medieval – texts not been taken seriously as a literary practice to date? In DERIVATE, I investigate the striking surge of retellings in contemporary English literature by setting the contemporary texts in a productive dialogue with practices of writing in the Middle Ages. The medieval period offers a perfect point of departure for theorizing retellings as medieval",{"id":219,"funder":7,"programme":8,"title":220,"piName":10,"institution":221,"country":20,"year":13,"amount":222,"abstract":223},"cordis-european-research-council-award-101125560","Tracking adaptation of naïve T cells to distinct organs  to decode organ-specific immune diseases","UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF","€1,999,000","Organ-specific immune-mediated inflammatory diseases (IMIDs) have a growing socio-economic impact due to their steadily increasing incidence. At least two aspects are still unclear: what immunological mechanisms restrict these diseases to one or a set of specific organs and what triggers the continuously increasing incidence, particularly in industrialized countries. Increasing exposure to harmful environmental triggers, such as pollution but also Western diet, have been suggested as potential r",{"id":225,"funder":7,"programme":8,"title":226,"piName":10,"institution":227,"country":228,"year":13,"amount":229,"abstract":230},"cordis-european-research-council-award-101126050","Unraveling the impact of turbulence in Mixed-phase Clouds","CHALMERS TEKNISKA HOGSKOLA AB","SE","€1,998,531","Mixed-phase clouds—atmospheric complex three-phase systems containing suspended ice particles, supercooled water droplets, and water vapor—are responsible for most of the precipitations reaching the Earth’s surface. In addition, these clouds play a primary role in the planet’s radiative energy budget and the water cycle. Despite their relevance, there is a lack of a basic understanding of the complex hydrodynamics, heat, and mass transfer between the different water components with numerous scie",{"id":232,"funder":7,"programme":8,"title":233,"piName":10,"institution":234,"country":20,"year":13,"amount":235,"abstract":236},"cordis-european-research-council-award-101123802","Diffuson-related transport in ionically conducting solids","UNIVERSITAET MUENSTER","€1,999,750","In DIONISOS, we aim to develop new analytical relationships for ion- and heat-transport in ionicconductors, and thus heal significant inconsistencies of the current understanding. Currently ion- andheat transport are interpreted as unrelated phenomena; ion transport being based on local jumps,whereas heat transport being mediated by dynamic lattice vibrations called phonons.Among other studies, my pioneering works in the field of solid ionic conductors (J. Am. Chem. Soc.2017, J. Am. Chem. Soc. 2",{"id":238,"funder":7,"programme":8,"title":239,"piName":10,"institution":152,"country":40,"year":13,"amount":240,"abstract":241},"cordis-european-research-council-award-101126257","Switching Polytypes and Symmetries by Discrete vdW Sliding","€2,061,775","While the artificial design of pristine crystalline structures and the construction of dedicated periodic playgrounds for atoms and electrons in a solid have transformed our world, much is yet to be explored. I posit that the marvels of van der Waals polytypes should go much beyond and suggest that they offer a remarkable opportunity to rapidly, efficiently, and distinctively swap between numerous different crystals, symmetries, and dispersions at will.We have recently reported several new cryst",{"id":243,"funder":7,"programme":8,"title":244,"piName":10,"institution":245,"country":83,"year":13,"amount":246,"abstract":247},"cordis-european-research-council-award-101124411","Tailoring Organic-Inorganic Layered Structures to Build Functional Graded 2D Nanomaterials for Advanced Nanointerfaces","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","€1,996,889","Advanced functional devices require integration of distinct materials (polymers, ceramics, metals) with different properties to achieve high performance in aerospace, biomedicine, electronic, and automotive. A major structural challenge is associated with localized (mechanical, thermal, electrical) stresses due to property mismatch at different scales, thus causing premature malfunction and failure. Research has focussed on compositional or structural material gradients (in at least one spatial ",{"id":249,"funder":7,"programme":8,"title":250,"piName":10,"institution":251,"country":40,"year":13,"amount":21,"abstract":252},"cordis-european-research-council-award-101124430","Towards an emerging field of social neuroscience in human groups","BAR ILAN UNIVERSITY","Group interaction is part of our evolutionary history and continues to be central to modern society. Whereas some groups function harmoniously and productively, others do not. Understanding group processes affecting these outcomes is vital because group discourse and actions affect individuals’ well-being and societal functioning. Examining the interactive biobehavioral processes that emerge between group members during shared tasks – the processes that influence actions, emotions, and cognition",{"id":254,"funder":7,"programme":8,"title":255,"piName":10,"institution":256,"country":135,"year":13,"amount":257,"abstract":258},"cordis-european-research-council-award-101123174","Elucidating the cutoff phenomenon","UNIVERSITE PARIS DAUPHINE","€1,403,750","The cutoff phenomenon is an abrupt transition from out of equilibrium to equilibrium undergone by certain Markov processes in the limit where the size of the state space tends to infinity: instead of decaying gradually over time, their distance to equilibrium remains close to the maximal value for a while and suddenly drops to zero as the time parameter reaches a critical threshold known as the mixing time.Discovered four decades ago in the context of card shuffling, this dynamical phase transit",{"id":260,"funder":7,"programme":8,"title":261,"piName":10,"institution":262,"country":228,"year":13,"amount":263,"abstract":264},"cordis-european-research-council-award-101126181","How to make a limb: a new insight using  three-dimensional synchrotron palaeohistology","UPPSALA UNIVERSITET","€1,856,316","Tetrapods, i.e. four-limbed animals, are the only backboned animals to have truly conquered the land, and have achieved worldwide distribution in a wide range of environments. Several fish groups have attempted to colonise terrestrial habitats (e.g. mudskippers among ray-finned fish; lungfish among lobe-finned fish) but only tetrapods were able to initiate a large-scale radiation. What is the key to this success? Our limb skeletons have obviously played a crucial part, by allowing us to walk and",{"id":266,"funder":7,"programme":8,"title":267,"piName":10,"institution":268,"country":12,"year":13,"amount":21,"abstract":269},"cordis-european-research-council-award-101124939","Molecular Control and Characterization of Chiral Hydrogen-bond Networks","UNIVERSIDAD DE VALLADOLID","Chirality and water both play key roles in various aspects of biological functions and disentangling water’s role in chiral recognition in biological processes is paramount to ultimately understanding the origins of homochirality. HydroChiral proposes to do this by developing ground-breaking instrumentation that uses broadband molecular rotational spectroscopy combined with supersonic expansions, buffer gas cell technology, and novel chiral capabilities to explore pressings topics at the forefro",{"id":271,"funder":7,"programme":8,"title":272,"piName":10,"institution":117,"country":20,"year":13,"amount":273,"abstract":274},"cordis-european-research-council-award-101124227","Power, Politics and Contestation in Global Technical Standard-Setting","€1,999,951","The governance of global technical standard-setting is in the midst of unprecedented transformation and contestation. Long dominated by wealthy industrialized countries, international standardization organizations have been shaken by the emergence of rising standards powers, above all China. Alongside China, several other Global South countries are now breaching the high barriers to entry in this field.TECHtonics will contribute two theoretical innovations addressed to both the international sta",{"id":276,"funder":7,"programme":8,"title":277,"piName":10,"institution":278,"country":111,"year":13,"amount":279,"abstract":280},"cordis-european-research-council-award-101125017","Persianate Jews: Mobility, Community, Memory","OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN","€1,684,949","Who are Persian Jews and what can we learn from their history? Looking back on a history of almost 3000 years, the majority of Jews left the Persianate world from the mid-20th century onwards. As Jews who lived in Muslim cultures, their trajectories do not fit into mutually exclusive concepts of “Jews” and “Muslims”. However, we hardly know how interactions between Muslims and Jews worked on a daily basis because the contemporary narratives about Jewish-Muslim relations tend to be highly polariz",{"id":282,"funder":7,"programme":8,"title":283,"piName":10,"institution":284,"country":285,"year":13,"amount":286,"abstract":287},"cordis-european-research-council-award-101125731","Capturing the evolution of a transformative cognitive capacity: the case of vocal learning in dogs","EOTVOS LORAND TUDOMANYEGYETEM","HU","€2,573,296","Modifying the vocal repertoire using an external auditory model is a prerequisite for speech production. But how full-fledged vocal learning evolved in humans, uniquely among primates, is still unclear. Integrating recent evidence from ethology and genetics, I hypothesize that selection for tameness, alloparental behavior and cooperativity in concert were the key driving processes for the emergence of human vocal learning and speech. I propose that dogs constitute an ideal model to test this hyp",{"id":289,"funder":7,"programme":8,"title":290,"piName":10,"institution":146,"country":20,"year":13,"amount":291,"abstract":292},"cordis-european-research-council-award-101122348","Beyond the Big Tech: Contentious Speech on Small Platforms","€1,988,113","In 2022, following Elon Musks takeover of Twitter, users of the microblogging platform who feared a rise in far-right discourses with the new owners idiosyncratic free speech policies, announced their migration to Mastodona free, federated social networking service. In 2021, in India, following Twitters actions against hateful speech, religious majoritarian actors rushed to secure their spot on Koo, a new homegrown platform. In the UK, Britain First, a far-right movement known for its anti-immig",{"id":294,"funder":7,"programme":8,"title":295,"piName":10,"institution":296,"country":20,"year":13,"amount":297,"abstract":298},"cordis-european-research-council-award-101126078","Universal Model of the Density of Deep Silicate Melts","GFZ HELMHOLTZ-ZENTRUM FUR GEOFORSCHUNG","€1,998,856","The starting conditions for the Earth’s evolution were set by gravitational differentiation in the solidifying magma ocean. Yet, a thorough understanding of the magma ocean dynamics and thus of the primordial Earth is lacking. One key unknown is the density of silicate melts at high pressure, which determines whether the crystallizing phases rise or sink. Magma density also governs the storage, spatial distribution, and migration of melts in the present-day Earth. Densities of silicate liquids a",{"id":300,"funder":7,"programme":8,"title":301,"piName":10,"institution":302,"country":40,"year":13,"amount":303,"abstract":304},"cordis-european-research-council-award-101125683","A general approach for the design of covalent protein proximity inducers","WEIZMANN INSTITUTE OF SCIENCE","€1,998,744","Chemical biology has made remarkable strides over recent decades, producing potent and selective inhibitors for many proteins, including essential drug targets. Despite these achievements, however, inhibition has been the primary mode of perturbation (GPCRs notwithstanding), whereas many biological processes are controlled through a rich spectrum of biochemical perturbations. What if a small molecule could activate an enzyme? Install or remove a post-translational modification (PTM)? Or control ",{"id":306,"funder":7,"programme":8,"title":307,"piName":10,"institution":39,"country":40,"year":13,"amount":308,"abstract":309},"cordis-european-research-council-award-101125913","Enhancing Protections through the Collective Auditing of Algorithmic Personalization","€1,741,309","The structure of the current data ecosystem carries grave threats to individuals' privacy and autonomy, facilitates discrimination, promotes social fragmentation, and threatens our ability to govern ourselves. Many of these concerns stem specifically from algorithmic personalization---the practice of providing individuals with personalized opportunities, information, or experiences, on the basis of their personal data and on patterns learned from others' data. Despite the urgency of the algorith",{"id":311,"funder":7,"programme":8,"title":312,"piName":10,"institution":262,"country":228,"year":13,"amount":313,"abstract":314},"cordis-european-research-council-award-101126121","Revealing an active mechanism of horizontal gene transfer in fungi","€1,999,996","Current theory asserts that eukaryotic evolution is almost exclusively mediated through vertical transmission, from parent to offspring, and relegates horizontal gene transfer (HGT), the movement of genes between individuals, to an extraordinarily rare event. In recent years, mounting evidence from high-quality genome sequencing has forced the field to consider that HGT is likely a persistent occurrence in eukaryotic evolution. However, as no active mechanism for HGT is known in eukaryotes, the ",{"id":316,"funder":7,"programme":8,"title":317,"piName":10,"institution":318,"country":95,"year":13,"amount":319,"abstract":320},"cordis-european-research-council-award-101125003","The Upcycled Clinic: A global ethnography of material creativity in contemporary medicine","UNIVERSITEIT MAASTRICHT","€1,999,865","As the world wades through Covid-19 pandemic debris, it becomes harder to ignore that medicine is a distinctly wasteful enterprise. Hospitals in particular have become nodes of disposability. Solutions to this problem has to date attracted mostly the attention of medical technology companies promoting circular economies, a model still reliant on production and technological innovation. The Upcycled Clinic takes a different direction. This ethnographic project focuses on creative practices such a",{"id":322,"funder":7,"programme":8,"title":323,"piName":10,"institution":324,"country":27,"year":13,"amount":325,"abstract":326},"cordis-european-research-council-award-101124189","Animal Communicators: Intuitive communication as a key to dialogic multispecies methods","UNIVERSITE DE LIEGE","€2,270,511","As the ‘social’ in social sciences is rethought beyond the human, multispecies research across disciplines increasingly asks how to speak with and for non-human others. I pose that intuitive interspecies communication (IIC), a strategy practiced by successful animal communicators to engage in explicit, detailed, two-way communication with non-human animals, holds uncharted resources for doing research with rather than on animals. Research on IIC has been curtailed to specific domains and mytholo",{"id":328,"funder":7,"programme":8,"title":329,"piName":10,"institution":39,"country":40,"year":13,"amount":330,"abstract":331},"cordis-european-research-council-award-101125620","The Making of Local Legal Cultures under Rome: A View from the Margins","€1,999,019","Law and order were Rome’s vehicles for displaying its imperial authority and supremacy over non-Roman subjects. However, Rome did not fill a legal vacuum; rather, it competed with established legal practices among communities in the Greek East. These communities took pride in their legal traditions, as they were being absorbed into the Roman legal order. Consequently, the sphere of law served provincials as a major arena for negotiating Roman power and demarcating their own local identities: wha",{"id":333,"funder":7,"programme":8,"title":334,"piName":10,"institution":188,"country":95,"year":13,"amount":335,"abstract":336},"cordis-european-research-council-award-101124886","Trajectories of taste: An analytical framework of culinary change after migration","€1,999,401","How and why do cuisines change after migration? The TASTE Project offers a novel approach to study the global spread of cooking techniques, products, dishes, recipes, food practices, and taste hierarchies. By focusing on three relatively old Indonesian diasporas (of Suriname, Sri Lanka, and South Africa), its researchers address the following hypotheses: 1. What people choose to eat is primarily driven by embodied notions of taste;2. Food preferences are inherited and exchanged;3. Culinary chang",{"id":338,"funder":7,"programme":8,"title":339,"piName":10,"institution":340,"country":20,"year":13,"amount":341,"abstract":342},"cordis-european-research-council-award-101123732","Scaling fluid-driven processes: Building Collapse in Extreme Flow Conditions","TECHNISCHE UNIVERSITAET BRAUNSCHWEIG","€2,125,908","Many Earth system processes involving multi-physics, multi-phase conditions extend over several orders of magnitude in length- and time-scales. Engineering science, in pursuit of deeper process understanding and solution-oriented design, has used scaling theories to address scale-afflicted, complex processes through experimental work in laboratory environment at reduced scale. The standard scaling approach, the Buckingham -theorem, is especially deficient when multi-physics and multi-phase proce",{"id":344,"funder":7,"programme":8,"title":345,"piName":10,"institution":346,"country":20,"year":13,"amount":347,"abstract":348},"cordis-european-research-council-award-101123955","Advanced Numerics for Uncertainty and Bayesian Inference in Science","EBERHARD KARLS UNIVERSITAET TUEBINGEN","€1,997,250","Scientific knowledge enters computers through data on the one side, and laws of nature – implicit equations like differential equations and symmetries – on the other. They both provide information, empirical and mechanistic, respectively, crucial to the deduction of new insights. But the algorithms that operate on these sources of information stem from different communities and different eras: machine learning – big data – on the one hand, and simulation methods – high performance computing – on",{"id":350,"funder":7,"programme":8,"title":351,"piName":10,"institution":352,"country":12,"year":13,"amount":353,"abstract":354},"cordis-european-research-council-award-101125962","Engineered carrier transport in nanostructured semiconductors using functional disorder.","UNIVERSIDAD AUTONOMA DE MADRID","€1,995,625","Disorder is generally considered to have a purely negative impact on carrier transport and most efforts aim to minimize it. However, recent studies suggest that disorder may enhance carrier transport via carrier funneling along energetic gradients or promote carrier interconversion at defect sites. Critically though, before disorder can be exploited for improved optoelectronic performance of nanomaterials, a better understanding of the relationship between disorder and transport is needed. EnVis",{"id":356,"funder":7,"programme":8,"title":357,"piName":10,"institution":358,"country":20,"year":13,"amount":359,"abstract":360},"cordis-european-research-council-award-101125914","High-resolution Boron and beyond Geologic reconstructions for carbon and climate processes","HELMHOLTZ-ZENTRUM FUR OZEANFORSCHUNG KIEL (GEOMAR)","€1,999,925","The link between climate and CO2 is not always straightforward, particularly during periods of multiple climatic and environmental changes, but atmospheric carbon dioxide (CO2) plays an important part in determining climate on human and geological timescales. For example, state dependency of climate sensitivity, the response of Earth’s temperature to CO2, is a critical unknown for future climate projections and policy strategies. Another unknown is the response of the Antarctic Ice Sheet (AIS) a",{"id":362,"funder":7,"programme":8,"title":363,"piName":10,"institution":188,"country":95,"year":13,"amount":364,"abstract":365},"cordis-european-research-council-award-101125937","On the evolutionary significance of wild animal reproductive microbiomes","€2,130,739","Our view of microbes has recently undergone a paradigm shift (the so-called microbiome revolution). Previously seen as unwanted harbingers of disease, it is now widely recognised that microbes can be beneficial and that the millions of microbes living in and on the bodies of animals and plants (i.e., the microbiome) can have profound effects on host biology. However, with the exception of the human vaginal microbiome, the microbiome revolution has largely overlooked the reproductive microbiome. ",{"id":367,"funder":7,"programme":8,"title":368,"piName":10,"institution":369,"country":20,"year":13,"amount":370,"abstract":371},"cordis-european-research-council-award-101125605","Altered brain-periphery crosstalk as a key pathomechanism for high-risk phenotypes in humans","UNIVERSITAET ULM","€1,999,838","Diabetes is a leading cause for morbidity and mortality worldwide. In our fight against the diabetes pandemic, my team and I recently identified subgroups of humans that are predictive for future life-threatening complications even before diabetes onset. Classification into these new risk groups is currently purely based on extensive phenotyping, yet, the underlying mechanisms are unclear. Of note, phenotypes of very high-risk persons are highly reminiscent of those from subjects with altered pe",{"id":373,"funder":7,"programme":8,"title":374,"piName":10,"institution":375,"country":83,"year":13,"amount":376,"abstract":377},"cordis-european-research-council-award-101125466","Redesigning aortic endograft: enabling in-situ personalized aneurysm healing","UNIVERSITA DEGLI STUDI DI PAVIA","€1,991,225","Forty years ago, the endograft (EG) enabled the endovascular treatment of aortic aneurysm (AoA) and revolutionized vascular surgery. Still, since then, its technological concept has remained substantially unchanged: EG is a passive device aimed at treating the AoA in its late stage, not to cure the disease, even when discovered early. This proposal introduces a bio-engineered process to redesign EGs as 3D bio-printed, bioresorbable devices loaded with active drug components and validated in-vitr",{"id":379,"funder":7,"programme":8,"title":380,"piName":10,"institution":381,"country":382,"year":13,"amount":383,"abstract":384},"cordis-european-research-council-award-101125499","Dissecting the role of rapid auxin responses in plant morphogenesis","USTAV EXPERIMENTALNI BOTANIKY AV CR","CZ","€1,999,660","Plant cells, living in their cell walls, are immobile and thus tightly control growth to shape their organs and bodies. Mechanical properties of the cell wall are modulated by pH, which is governed by the activity of plasma membrane proton ATPases. The central regulator of plant growth, phytohormone auxin, regulates gene transcription. My team and I have significantly contributed to recent discoveries of additional auxin signaling pathways that act rapidly, in a non-genomic manner. Surprisingly,",{"id":386,"funder":7,"programme":8,"title":387,"piName":10,"institution":358,"country":20,"year":13,"amount":141,"abstract":388},"cordis-european-research-council-award-101125296","Novel in situ imaging technology to explore the “ladder of vertical migrations” to the deep-sea","The pelagic deep ocean is the largest but least-understood habitat on Earth, harboring enormous fish stocks, a rich (and largely undiscovered) biodiversity, as well as a large carbon sink in the climate system. As almost all life at depth is ultimately nourished by primary production in the surface ocean, pathways of “vertical connectivity” are critical in linking ecological and biogeochemical processes across several thousands of meters. One of the most enigmatic phenomena is the so far virtual",{"id":390,"funder":7,"programme":8,"title":391,"piName":10,"institution":392,"country":20,"year":13,"amount":393,"abstract":394},"cordis-european-research-council-award-101125947","Unveiling atomic-scale elemental distribution of electrode\u002Felectrolyte interfaces and interphase in batteries","RUHR-UNIVERSITAET BOCHUM","€2,201,834","Developing high-energy-density rechargeable battery technologies is essential to solve energy and environmental problems. However, its development is currently impeded by a poor understanding of elementary processes occurring at electrode\u002Felectrolyte interfaces. Several long-standing issues such as short cycle life, low Coulombic efficiency and hazardous dendrite formation in batteries cannot be fundamentally solved due to the knowledge gap. The bottleneck is that interfacial chemistry on the at",{"id":396,"funder":7,"programme":8,"title":397,"piName":10,"institution":398,"country":135,"year":13,"amount":399,"abstract":400},"cordis-european-research-council-award-101124214","Monsoon Asia as the Nexus for the Transfer of Tantra along the Maritime routes","ECOLE PRATIQUE DES HAUTES ETUDES","€1,972,125","Tantra dominated the Hindu and Buddhist socio-religious landscape across much of southeastern Asia from ca. the 7th to the 13th century. Once perceived ambivalently by scholars, and often still misrepresented in global pop culture as a form of sexual practice, the study of Tantra has now become a burgeoning academic subfield. However, the impact of Tantra on the religio-cultural history of Asia is still underappreciated, and disciplinary limitations as well as the Area Studies paradigm, fragment",{"id":402,"funder":7,"programme":8,"title":403,"piName":10,"institution":404,"country":12,"year":13,"amount":405,"abstract":406},"cordis-european-research-council-award-101123223","Stable solutions and nonstandard diffusions: PDE questions arising in Mathematical Physics","UNIVERSITAT DE BARCELONA","€1,682,500","The concept of diffusion is ubiquitous in the physical sciences. From the mathematical point of view, its study started in the early 19th century with the development of PDE theory, and has many connections to Physics, Probability, Geometry, and Functional Analysis. This project aims to answer several outstanding questions related to the mathematics of diffusion.The proposal is divided into two blocks. The first one corresponds to the study of stable solutions to reaction-diffusion PDE, and more",{"id":408,"funder":7,"programme":8,"title":409,"piName":10,"institution":410,"country":83,"year":13,"amount":411,"abstract":412},"cordis-european-research-council-award-101124518","A Continent Disarmed?  Gun Culture, Gun Control and the Making of Western Europe (ca. 1870-1970)","UNIVERSITA DEGLI STUDI DI PADOVA","€1,999,913","This research project is a comparative and transnational historical investigation of the lawful possession and use of small firearms by law-abiding civilians in Europe between ca. 1870 and ca. 1970. Over the course of this century-long period, Europe underwent a silent revolution, which led it from being a continent where guns were in daily use to becoming a place where weapons in civilians’ hands became associated with violence and crime. This led to the progressive establishment of gun control",{"id":414,"funder":7,"programme":8,"title":415,"piName":10,"institution":416,"country":111,"year":13,"amount":417,"abstract":418},"cordis-european-research-council-award-101123041","Early Earth, Mars and Venus as Exoplanets (EASE)","UNIVERSITAT WIEN","€1,985,871","The era of the James Webb Space Telescope (JWST) has opened a new chapter in exoplanetary research. We cannot understand exoplanets without looking back at the cradle of life as we know it - the Earth. Why did the Earth become a habitable planet? Why did Mars and Venus evolve differently? What would JWST see if it looked at the solar system planets as they were billions of years ago? My team will investigate the long-term evolution of the atmospheres and spectral fingerprints of Earth, Venus, an",{"id":420,"funder":7,"programme":8,"title":421,"piName":10,"institution":422,"country":27,"year":13,"amount":423,"abstract":424},"cordis-european-research-council-award-101124701","Metropolises in the Mud Innovation in Delta Building Technology in Europe and China in the pre-Industrial Age","KATHOLIEKE UNIVERSITEIT LEUVEN","€1,995,000","Deltas are among the most urbanised and wealthiest regions of the world. Today, their very existence is threatened by climate change. Innovative solutions are urgently needed, and delta cities around the globe have joined forces to confront the climate crisis. The dependence on innovation for their survival is however not a recent phenomenon but has a longer history. Surprisingly, little is known about the specialised skills and knowledge shown by earlier civilisations in constructing and protec",{"id":426,"funder":7,"programme":8,"title":427,"piName":10,"institution":262,"country":228,"year":13,"amount":428,"abstract":429},"cordis-european-research-council-award-101044731","Slavery, Abolition and Archipelagic Connections in the Swedish Caribbean","€1,992,925","Surveys and datasets of the trans-Atlantic slave trade do not include Swedish slave trade and colonial history. Yet, when Sweden acquired the Antillean island Saint Barthélemy in 1784 it became a slaving nation that traded and smuggled captive Africans and punished the enslaved population using draconic slave laws until the abolition of Swedish slavery in 1847. The project is the first investigation of new sources and it situates Swedish colonialism in the Caribbean archipelago. By shifting the ",{"id":431,"funder":7,"programme":8,"title":432,"piName":10,"institution":433,"country":20,"year":13,"amount":434,"abstract":435},"cordis-european-research-council-award-101125209","Decoding subcellular spatial biology with high precision using RNA photocatalysts","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","€1,999,525","RNA is a fundamental component of life. Complex, dynamic, and spatial networks of molecular interactions between RNAs and other biomolecules are essential for maintaining cellular homeostasis. Disruptions in the RNA interactome have been linked to a number of human diseases, implying that these molecular interactions could represent a new family of unexploited therapeutic targets. Despite the growing appreciation of the importance of RNA, discovery, and characterization of RNA interactions at th",{"id":437,"funder":7,"programme":8,"title":438,"piName":10,"institution":392,"country":20,"year":13,"amount":439,"abstract":440},"cordis-european-research-council-award-101124914","Probing the Finely-resolved 100 TeV Gamma-ray Sky for Ultra-heavy Dark Matter","€2,331,823","Dark100 will shine a light into an underexplored dark matter particle mass range. Driven by recent theoretical developments, both in tools and motivation, Dark100 will search for dark matter particles between 100 TeV and several tens of PeV. Leveraging novel, cost-effective telescope technology, Dark100 will deploy an array of telescopes capable of probing dark matter annihilation, improving on the sensitivity of currently operating and planned gamma-ray instruments by an order of magnitude with",{"id":442,"funder":7,"programme":8,"title":443,"piName":10,"institution":444,"country":445,"year":13,"amount":446,"abstract":447},"cordis-european-research-council-award-101125245","Oral antibiotic outpatient therapy vs. placebo in the treatment of uncomplicated acute appendicitis: a randomized double-blind placebo-controlled noninferiority trial","TURUN YLIOPISTO","FI","€1,994,895","Acute appendicitis is one of the most common surgical emergencies worldwide. For over a century, surgical removal of the appendix has been considered the only treatment option. Landmark trials by our experienced APPAC team have shown that imaging confirmed uncomplicated acute appendicitis is not a surgical emergency defining antibiotics to safe and effective also with only oral antibiotics avoiding unnecessary surgeries resulting in major cost and resource savings. However, the role of antibioti",{"id":449,"funder":7,"programme":8,"title":450,"piName":10,"institution":451,"country":27,"year":13,"amount":452,"abstract":453},"cordis-european-research-council-award-101124572","LAgrangian Climate Risk and Impact Attribution","VRIJE UNIVERSITEIT BRUSSEL","€1,999,590","Under a continued increase in global warming, extreme events such as heatwaves will further rise in frequency, intensity, and duration over the next decades. Climate change impact studies routinely assess hazard and exposure change across discrete time windows, but thereby fail to grasp how vulnerability and climate risk evolve across a persons lifetime. Conversely, demographic research has a long tradition of assessing population processes and vulnerability from a cohort perspective, but genera",{"id":455,"funder":7,"programme":8,"title":456,"piName":10,"institution":457,"country":20,"year":13,"amount":458,"abstract":459},"cordis-european-research-council-award-101124992","Migration trajectories, natural experiments and effects of small-area contexts on health: a privacy-preserving linkage study of routine and primary data among resettlement refugees","UNIVERSITAET BIELEFELD","€1,999,990","The health effects of the migration trajectory, from pre- to post-migration in new environments, have yet been poorly studied. Methodological challenges and selection effects limit the possibilities for causal inferences on how differences in social, economic, or political factors at small-area level affect variation in health among migrants (e.g. differential mortality or self-reported health). Knowledge about such relations would not only inform better and health and integration policies for m",{"id":461,"funder":7,"programme":8,"title":462,"piName":10,"institution":463,"country":20,"year":13,"amount":464,"abstract":465},"cordis-european-research-council-award-101124385","Explainable Machine Learning for Identifying the Full Heterogeneity of Peptidoforms and Proteoforms","HASSO-PLATTNER-INSTITUT FUR DIGITAL ENGINEERING GGMBH","€1,992,500","Mass spectrometry driven proteomics allows deep insights into the working of cells. Still, the vast majority of proteoforms, representing the full heterogeneity of molecular forms of protein products in a sample,  currently remain undetected in proteomics experiments. This lack of information strongly restricts our knowledge of disease progression, possible biomarkers, and therapeutic targets across a large number of diseases. Several machine learning approaches have been developed for proteomic",{"id":467,"funder":7,"programme":8,"title":468,"piName":10,"institution":469,"country":20,"year":13,"amount":470,"abstract":471},"cordis-european-research-council-award-101123544","Experimental replication of historical reanalysis processes","FREIE UNIVERSITAET BERLIN","€1,980,706","Background. In historical linguistics, reanalysis is described as process by which speakers assign a new meaning to a superficially unchanged element. Reanalysis is basic to grammar change. However, due to the methodological difficulty of studying change on the basis of historical texts and limitations in the understanding of associated social processes, current research struggles to explain both why and when reanalysis occurs and why it spreads between speakers.Aim. EXREAN has three main innova",{"id":473,"funder":7,"programme":8,"title":474,"piName":10,"institution":475,"country":83,"year":13,"amount":476,"abstract":477},"cordis-european-research-council-award-101126209","In-situ fetoscopic 3D bioprinting for spina bifida treatment","POLITECNICO DI MILANO","€1,972,500","Currently available pre-birth surgical treatments for Spina Bifida Aperta (SBA) still do not provide a complete recovery in babies and would potentially benefit from a tissue engineering approach, indeed the first clinical trial using stem cells for SBA has recently started, however this is performed via an open-uterus approach. This made me wonder, what if we can develop an innovative system to deliver via fetoscopy a bioprinted tissue engineering costructfor SBA repair? Such an approach would ",{"id":479,"funder":7,"programme":8,"title":480,"piName":10,"institution":422,"country":27,"year":13,"amount":481,"abstract":482},"cordis-european-research-council-award-101124789","Amenable C*-dynamics and their classification","€1,940,875","Our understanding of amenable C*-algebras has drastically improved over the past decade due to substantial advances in the Elliott classification program. The proposed research is intended to spearhead the classification and structure theory for C*-dynamics, which encompasses groups acting continuously on C*-algebras and the question to which extent their detailed structure is encoded at the level of computable invariants. The objectives involve the following lines of investigation:- The case of",{"id":484,"funder":7,"programme":8,"title":485,"piName":10,"institution":486,"country":20,"year":13,"amount":487,"abstract":488},"cordis-european-research-council-award-101125178","Engineering Magneto-ionic Materials for Energy-Efficient  Actuation and Sensing: From Interfaces to Multifunctional Voltage-Tunable Micromagnets","TECHNISCHE UNIVERSITAET CHEMNITZ","€1,994,165","ACTIONS proposes a material-based concept to drastically reduce the energy consumption of magnet-based micro- and nanotechnologies. Magnetic systems offer unique advantages for actuation in miniature fluidic and robotic systems, but their integration is hindered because electromagnets are required to create time-varying magnetic fields, causing joule energy loss and heat effects. Alternative control of magnetic materials using an electric field instead of electric current would present an energy",{"id":490,"funder":7,"programme":8,"title":491,"piName":10,"institution":422,"country":27,"year":13,"amount":10,"abstract":492},"cordis-european-research-council-award-101122653","CertiFOX: Certified First-Order Model Expansion","The field of combinatorial optimization is concerned with developing generic tools that take a declarative problem description and automatically compute an optimal solution to it. Often, users specify their problem in a high-level, human-understandable formal language. This specification is first translated into a low-level specification a solver understands and subsequently solved. Thanks to tremendous progress in solving technology, we can now solve a wide variety of NP-hard (or worse) problem",{"id":494,"funder":7,"programme":8,"title":495,"piName":10,"institution":496,"country":20,"year":13,"amount":147,"abstract":497},"cordis-european-research-council-award-101123921","Magnetic memory supraparticles for perceptual matter","FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG","So far, materials are seen as passive items. This project aims at providing a solution that can turn objects into matter that can perceive and communicate trigger events. If materials are turned capable of reporting their encountered history, this will significantly contribute to i) ensuring product safety and reliability, ii) making predictive maintenance possible, iii) making complex recycling fates of materials transparent, and iv) enabling autonomous, robot-controlled, resilient manufacturin",{"id":499,"funder":7,"programme":8,"title":500,"piName":10,"institution":416,"country":111,"year":13,"amount":501,"abstract":502},"cordis-european-research-council-award-101124903","Digital twin politics: Unlocking the full potential of digital twins for sustainable ocean futures","€1,999,734","In the light of time pressure, persisting data gaps, and challenges to the implementation of global sustainability goals for ocean protection, the European Commission is currently building a prototype digital twin of the ocean (DTO). The EU DTO is part of a larger set of substantial global and national efforts to develop highly accurate digital models of the ocean for ‘better decision-making’ and an emerging high-tech knowledge infrastructure that turns various types of ocean data into predictio",{"id":504,"funder":7,"programme":8,"title":505,"piName":10,"institution":506,"country":83,"year":13,"amount":507,"abstract":508},"cordis-european-research-council-award-101124725","Unpacking Mixedness for an Inclusive History of the Red Sea, 1800s-2000s","UNIVERSITA DEGLI STUDI DI TORINO","€1,864,059","The debate on mixed-race people is gaining momentum, and the Red Sea  located at the crossroads of Africa and the Middle East, of the Mediterranean Sea and the Indian Ocean  stands as a privileged venue to investigate mixedness. Focusing on a timeframe (1800s-2000s) marked by increasing mobilities and mixed-race unions and offspring (e.g. Afro-Arabs, Afro-Asians, Euro-Africans), REDMIX investigates the roots and routes of mixed-race people and groups through a bottom-up, long-term, and interdisc",{"id":510,"funder":7,"programme":8,"title":511,"piName":10,"institution":512,"country":513,"year":13,"amount":514,"abstract":515},"cordis-european-research-council-award-101126229","Limits of Structural Tractability","UNIWERSYTET WARSZAWSKI","PL","€1,935,074","The combination of methods from logic and graph theory has been extremely successful in the design of algorithms, in complexity theory, and other areas of theoretical computer science. A success story exemplifying the power of this approach is the recent development in the algorithmic structure theory of sparse graphs. In this line of research, structural results stemming from Robertson and Seymour’s graph minor theory, and the more recent sparsity theory of Nešetřil and Ossona de Mendez, were c",{"id":517,"funder":7,"programme":8,"title":518,"piName":10,"institution":519,"country":520,"year":13,"amount":21,"abstract":521},"cordis-european-research-council-award-101125803","Morphogenesis meets Cell Fate: Dissecting how Mechanical Forces coordinate Development","KOBENHAVNS UNIVERSITET","DK","During embryonic development, an unspecialized cell mass is transformed into complex tissues and organs through collective movements and cell interactions. The acquisition of such structural and functional diversity is powered by two main processes: morphogenesis, which sculpts cells into tissues and organs, and cell fate acquisition, which assigns specific identities to cells. Despite extensive research, the intricate coordination between these two processes remains elusive. Mechanical forces d",{"id":523,"funder":7,"programme":8,"title":524,"piName":10,"institution":525,"country":27,"year":13,"amount":526,"abstract":527},"cordis-european-research-council-award-101125638","Improving cereal yield predictions under drought: root diameter as a predictor of plant water uptake across scales.","UNIVERSITE CATHOLIQUE DE LOUVAIN","€1,996,749","As droughts are becoming more frequent and severe, there is a call for adaptation strategies that enhance the crop’s resilience to these climate conditions. One pathway to do so is to select crops whose root system optimize the soil water uptake. However, the identification of adequate ideotypes is compromised by the limited understanding of the structural drivers controlling the water uptake from the root to crop scales. This knowledge gap is attributable to the multiscale and nonlinear nature ",{"id":529,"funder":7,"programme":8,"title":530,"piName":10,"institution":531,"country":12,"year":13,"amount":41,"abstract":532},"cordis-european-research-council-award-101125843","Cocreating Actions to Improve Rationality in the health system","UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE","Despite widespread recognition of social, economic, or environmental health determinants, health action remains heavily dominated by individual-level solutions (e.g., medication, patient counselling, vaccination). This proposal aims to stimulate changes in health system functioning by demonstrating how the cocreation of actions to address psychological well-being, cardiovascular health, and antimicrobial resistance from within the community can alleviate the burden on primary care services, redu",{"id":534,"funder":7,"programme":8,"title":535,"piName":10,"institution":536,"country":228,"year":13,"amount":537,"abstract":538},"cordis-european-research-council-award-101125394","Core dynamics on millennial timescales","LUNDS UNIVERSITET","€1,999,854","PALEOCORE will provide the first comprehensive observational constraints on the dynamics of Earth’s core on multi-centennial to millennial timescales. Such constraints are essential to understand the core processes responsible for the rapid decay of Earth’s dipole field strength over the past century and to forecast future field changes.Generated through convective motions in the liquid iron core, Earth’s magnetic field acts as a shield against harmful cosmic radiation and plays a crucial role f",{"id":540,"funder":7,"programme":8,"title":541,"piName":10,"institution":542,"country":95,"year":13,"amount":21,"abstract":543},"cordis-european-research-council-award-101125504","Improving Kidney Health by Targeting  Urinary Biomarkers for Tubular Function","ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM","Chronic kidney disease (CKD) affects one in ten people worldwide and is often progressive. Progressive CKD not only causes kidney failure, but also premature aging, cardiovascular disease, and loss of quality of life. Currently, progressive CKD can only be diagnosed after irreversible damage to the kidney has already occurred. There is therefore an urgent need for earlier biomarkers. The kidney consists of filters and tubules, but diagnosis of progressive CKD is currently based on filter functio",{"id":545,"funder":7,"programme":8,"title":546,"piName":10,"institution":547,"country":83,"year":13,"amount":548,"abstract":549},"cordis-european-research-council-award-101125112","The Holographic Bootstrap","UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II","€1,996,250","The holographic principle is believed to embody key fundamental features of any quantum gravity theory. It can be seen as a profound consequence of the intrinsic tension between the definition of quantum observables and the fact that in a theory of gravity it is impossible to define such observables in any finite volume due to the existence of Black Holes. The aim of this project is to push the boundaries of the holographic principle beyond AdS space, formulating a set of self-consistency requir",{"id":551,"funder":7,"programme":8,"title":552,"piName":10,"institution":547,"country":83,"year":13,"amount":10,"abstract":553},"cordis-european-research-council-award-101124606","3D Cuprate Twistronics as a platform for high temperature topological superconductivity","2D superconductors can be used to build ultra-clean interfaces for Josephson junctions, the superconducting analog of a transistor. A small twist in the relative crystal orientation of 2D superconductors could become a new platform for topological superconductivity, an exotic state of matter that holds great promise for quantum computing at high temperatures. Based on my methodological developments for the realization of twisted cuprate ultra-clean interfaces, the field is rapidly evolving, and ",{"id":555,"funder":7,"programme":8,"title":556,"piName":10,"institution":557,"country":111,"year":13,"amount":558,"abstract":559},"cordis-european-research-council-award-101125225","New Frontiers in Optimal Adaptivity","TECHNISCHE UNIVERSITAET WIEN","€1,988,674","The ultimate goal of any numerical method is to achieve maximal accuracy with minimal computational cost. This is also the driving motivation behind adaptive mesh refinement algorithms to approximate partial differential equations (PDEs).PDEs are the foundation of almost every simulation in computational physics (from classical mechanics to geophysics, astrophysics, hydrodynamics, and micromagnetism) and even in computational finance and machine learning.Without adaptive mesh refinement such sim",{"id":561,"funder":7,"programme":8,"title":562,"piName":10,"institution":563,"country":95,"year":13,"amount":21,"abstract":564},"cordis-european-research-council-award-101125961","Computational Mechanisms of Social Media Use in Youth","UNIVERSITEIT VAN AMSTERDAM","We have an urgent need to better understand the social media engagement of youth. Social media supports the specific developmental needs of youth, such as those for social connection. However, the increased sensitivity of the developing brain to social rewards may place youth especially at risk. In addition, youth’s sensitivity to social influence exposes another potential vulnerability, given that not all information is trustworthy. Understandably, there have been widespread fears about the imp",{"id":566,"funder":7,"programme":8,"title":567,"piName":10,"institution":563,"country":95,"year":13,"amount":21,"abstract":568},"cordis-european-research-council-award-101125011","Eco-Islam in Indonesia: Media, Institutions, Publics","In Indonesia, the world’s most populous Muslim country, a so-called mediated “eco-jihad” (Zbidi 2013) has emerged. Today, Islamic ‘green’ pop musicians, eco-YouTube-imams, films, and social media (campaigns) find inspiration in religious scriptures to encourage Muslims to engage in environmental protection. For eco-conscious Muslims, the Qur’an is “the ultimate green-guide”. (Zaufishan 2013) The Qur’an is read by Muslims for spirituality, but the Qur’an also provides countless examples that coul",{"id":570,"funder":7,"programme":8,"title":571,"piName":10,"institution":572,"country":520,"year":13,"amount":573,"abstract":574},"cordis-european-research-council-award-101126012","Advanced Magnetic Components for High-Efficiency and High-Power-Density Converters","DANMARKS TEKNISKE UNIVERSITET","€1,998,736","Today’s magnetic components, such as inductors and transformers, in power converters operating at a low frequency of around 100-500 kHz are large compared to other electronic components. These components are a major constraint, limiting the miniaturization and integration of power electronic systems. Increasing the switching frequency can reduce the size of the magnetic components, but this is generally accompanied by significant power losses. I aim to address the fundamental challenges of magne",{"id":576,"funder":7,"programme":8,"title":577,"piName":10,"institution":416,"country":111,"year":13,"amount":578,"abstract":579},"cordis-european-research-council-award-101125639","Unearthing ancient social structures with sediment DNA","€1,994,458","Humans and other living beings are constantly shedding DNA, and this DNA is preserved in archaeological sediments. In 2021, I developed the first methods for reliably capturing and analyzing human nuclear ancient DNA (aDNA) from sediments, leveraging this abundant genetic resource as a reliable tracer of biological identity. For ancient societies, such aDNA has the potential to function as forensic “breadcrumbs” that trace the spaces inhabited by ancient individuals. At the well-documented, mult",{"id":581,"funder":7,"programme":8,"title":582,"piName":10,"institution":583,"country":20,"year":13,"amount":10,"abstract":584},"cordis-european-research-council-award-101124239","From CO2 and Nitrogen fixation to the delivery of therapeutic enzymes: Silicified DNA origami as artificial microcompartments","TECHNISCHE UNIVERSITAT DORTMUND","All life is dependent on enzymatic reactions and functional enzyme cascades have been evolutionary optimized. Yet, introducing “foreign” enzymes into other organisms through genetic engineering often results in reduced or no enzymatic activity. In nature enzymatic activity and efficiency are often enhanced by encapsulation of enzymes in microcompartments resulting in protection and rate enhancement through high local concentrations of enzymes, co-factors and substrates. In NanoCat I will enginee",{"id":586,"funder":7,"programme":8,"title":587,"piName":10,"institution":588,"country":20,"year":13,"amount":589,"abstract":590},"cordis-european-research-council-award-101125441","Using a natural approach to elucidate the neural mechanisms of alarm calling behaviour in birds.","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€1,917,188","“Watch out!” - is the term we use to inform somebody about a potentially dangerous situation. “Take cover!” - we shout when the threat is imminent. Not only humans but also animals use alarm calls to warn conspecifics about danger, and the value of these signals for increasing the chance of survival in the receiver is without controversary. But, alarm calls often harm the sender through their production and are therefore considered an evolutionary paradox, which has fascinated scientists for man",{"id":592,"funder":7,"programme":8,"title":593,"piName":10,"institution":594,"country":595,"year":13,"amount":596,"abstract":597},"cordis-european-research-council-award-101126337","A bio-archaeological study of 1,800 years of resilience and adaptation to urbanity","DIMOKRITIO PANEPISTIMIO THRAKIS","EL","€1,998,250","CityLife explores, from a bioarchaeological perspective, how historical populations adapted to an urban environment and developed resilience to the disadvantages of urban life. By exploiting the vast amount of information contained in human skeletal remains, the project will clarify the roles of biological factors in the durability and sustainability of pre-industrial urban societies. Newly developed osteological, chemical isotope, and genomic methods will be used in this project, together with ",{"id":599,"funder":7,"programme":8,"title":600,"piName":10,"institution":536,"country":228,"year":13,"amount":601,"abstract":602},"cordis-european-research-council-award-101125425","Early life imprinting of B cell memory and its role in adult immunity","€1,999,983","This proposal addresses the combined role of early life derived B cells in the adult immune system. Neonatal immune imprinting is now well-established concept. It emphasizes the importance of the early life window to establish host-microbial mutualism and the set-point for immune responsiveness later in life. However, the cellular and molecular mechanisms underlying this immune programming are not well understood. Despite the ability of B cells to integrate and store complex immunological memory",{"id":604,"funder":7,"programme":8,"title":605,"piName":10,"institution":606,"country":12,"year":13,"amount":607,"abstract":608},"cordis-european-research-council-award-101124719","Embracing Immigrant Knowledges for Just Climate Health Adaptation","UNIVERSITAT AUTONOMA DE BARCELONA","€1,985,268","Climate change, human health and immigration are arguably the most prominent, enduring, and challenging issues of our times, with important implications for justice. Studies on the nexus of these issues have largely focused on climate change as posing challenges to health and thus acting as a push-factor for migration. However, our understanding of how climate is impacting the health of immigrants in places of migration destination is still poor. Further limiting our understanding of potential c",{"id":610,"funder":7,"programme":8,"title":611,"piName":10,"institution":612,"country":595,"year":13,"amount":21,"abstract":613},"cordis-european-research-council-award-101124742","Learning to synthesize interactive 3D models","POLYTECHNEIO KRITIS","Visualizing our surroundings and imagination has been an integral part of human history. In today's era, we have the privilege to immerse in 3D digital environments and interact with virtual objects and characters. However, creating digital representations of environments (i.e., 3D models) often requires excessive amount of  manual effort and time even for trained 3D artists. Over the recent years, there have been remarkable advances in deep learning methods that attempt to reconstruct 3D models",{"id":615,"funder":7,"programme":8,"title":616,"piName":10,"institution":617,"country":95,"year":13,"amount":618,"abstract":619},"cordis-european-research-council-award-101124278","Understanding Lightning from the Lab: Initiation, Propagation, and X-ray Emissions","TECHNISCHE UNIVERSITEIT EINDHOVEN","€2,479,429","Despite the huge impact of lightning, its fundamental properties are still very poorly understood. With this project I want to build an infrastructure of carefully designed laboratory experiments in a novel physical regime, that will provide the conditions required to understand lightning phenomena. I will use this to answer some of the major open questions in lightning and high voltage discharge research. I will provide major scientific breakthroughs to answer the questions on 1) how lightning ",{"id":621,"funder":7,"programme":8,"title":622,"piName":10,"institution":617,"country":95,"year":13,"amount":623,"abstract":624},"cordis-european-research-council-award-101125457","Engineering QUAntum materials for TErahertz applications","€1,999,233","I propose to demonstrate a novel design paradigm for terahertz (THz) technologies, which places the ultrafast thermodynamic properties of quantum materials at the heart. Approaches with conventional semiconductors and metals, as well as recent attempts with two-dimensional materials, typically aim to exploit the optoelectronic properties of materials towards developing THz components and systems. This has so far not led to the desired breakthrough that the, currently still underdeveloped, terahe",{"id":626,"funder":7,"programme":8,"title":627,"piName":10,"institution":628,"country":95,"year":13,"amount":21,"abstract":629},"cordis-european-research-council-award-101124277","Leveraging the zombie-making strategies of Ophiocordyceps fungi to understand animal behaviour","UNIVERSITEIT UTRECHT","Reminiscent of zombies in pop culture, some parasites hijack host behaviours. Our understanding of this parasite strategy to improve transmission is minimal, despite its convergent evolution across major taxa. Functional genetics studies would advance our knowledge of the molecular underpinnings of “zombie behaviour”. Additionally, learning how behaviour can be altered would elucidate how “normal” phenotypes are maintained. However, most zombie-making parasites and their hosts are not classic mo",{"id":631,"funder":7,"programme":8,"title":632,"piName":10,"institution":628,"country":95,"year":13,"amount":21,"abstract":633},"cordis-european-research-council-award-101124393","Ecologies of Violence: Crimes against Nature in the Contemporary Cultural Imagination","The ongoing destruction of the natural world raises critical questions about responsibility. How do we remember the victims, both human and non-human? And who is to blame? Contemporary culture plays a crucial role in addressing these questions. Large-scale processes like ecocide and extinction pose significant conceptual and representational challenges. This project posits that writers, artists and filmmakers are responding to these challenges by adapting existing repertoires, especially ones th",{"id":635,"funder":7,"programme":8,"title":636,"piName":10,"institution":637,"country":83,"year":13,"amount":638,"abstract":639},"cordis-european-research-council-award-101125658","An Attentional Code for Memory","UNIVERSITA DEGLI STUDI DI TRENTO","€1,999,358","Declarative memory is fundamentally relational. We not only remember things or events, but also whether and how they are related to each other. Cracking the mental code that supports relational memory is one of the greatest challenges of cognitive neuroscience. Here I suggest that memories are relationally encoded through an attentional repertoire, such that different types of conceptual relationships (before\u002Fafter, bigger than, part of, caused by, etc.) correspond to different dynamic attention",{"id":641,"funder":7,"programme":8,"title":642,"piName":10,"institution":643,"country":445,"year":13,"amount":644,"abstract":645},"cordis-european-research-council-award-101124960","Mercury in the solar wind: adaptive kinetic model for space weather at solar system's innermost planet","ILMATIETEEN LAITOS","€1,997,101","We develop a new type of a global plasma simulation model with adaptive charged particle kinetic physics for the Mercury-solar wind interaction. Mercury’s solar wind interaction, or space weather, is unique in the solar system due to spatially small and temporally fast magnetospheric scales, airless solid body with a large conducting core, a tenuous surface-originating exosphere and the closest distance to the Sun of the planets. These features mean that Mercury is an ideal compact-sized magneto",{"id":647,"funder":7,"programme":8,"title":648,"piName":10,"institution":649,"country":445,"year":13,"amount":650,"abstract":651},"cordis-european-research-council-award-101123801","Shining Light on Saturated Gluons","JYVASKYLAN YLIOPISTO","€1,989,289","In this project the properties of hadronic matter with emergent non-linear saturation phenomena at extremely large parton densities are theoretically determined. This is achieved by studying  Quantum Chromodynamics (QCD), describing the strong interactions between quarks and gluons, at high energies.There are solid theoretical arguments formulated in the Color Glass Condensate (CGC) effective field theory to suggest that saturation effects play a major role in hadronic interactions at high energ",{"id":653,"funder":7,"programme":8,"title":654,"piName":10,"institution":655,"country":445,"year":13,"amount":21,"abstract":656},"cordis-european-research-council-award-101125115","Single cEll guided polygeniC Risk prEdicTion of ASCVD","ITA-SUOMEN YLIOPISTO","Atherosclerotic cardiovascular disease (ASCVD) is the most common cause of death worldwide. Aside from asymptomatic manifestations, the first sign of clinically significant ASCVD is often a severe clinical event, such as stroke or myocardial infarction. Thus, identification of people at high risk is central to battle the deadly consequences of ASCVD. The usefulness of current risk prediction models such as SCORE2 is unsatisfactory most likely since the score is built on prevalent risk factors ra",{"id":658,"funder":7,"programme":8,"title":659,"piName":10,"institution":660,"country":83,"year":13,"amount":661,"abstract":662},"cordis-european-research-council-award-101126116","Charting Female Property and Patrimonial Rights in Law and Practice Across Western Europe (12th-16th Centuries)","UNIVERSITA DEGLI STUDI DI GENOVA","€1,960,215","From the mid-12th century, all over Europe, laws started to be enacted that hindered women from acquiring and managing wealth, triggering a long process that on the threshold of early modernity led to a dramatic reduction in their economic opportunities. The importance of the issue is undeniable, not only because female agency has been a central theme in gender studies, but also because the effects of these developments are still felt today, yet the underpinnings of these developments are far fr",{"id":664,"funder":7,"programme":8,"title":665,"piName":10,"institution":666,"country":667,"year":13,"amount":235,"abstract":668},"cordis-european-research-council-award-101124215","GLOBAL CAPITALISM AND RURALITY: AGENCY, COMMODIFICATION AND THE SOCIO-ECOLOGICAL TRANSFORMATION OF THE MIDDLE EASTERN COUNTRYSIDE, 1870-1945","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","IE","The Middle East is rarely associated with global capitalism. And yet, capitalist expansion had a substantial impact on its modern history. While previous works address issues such as dependency and coloniality, state building, human-environmental interaction and connectivity, there is little recognition of the influence of global capitalism on the socio-ecological transformation of the rural Middle East. CAPITALEAST therefore compares tribes of diverse origins, examining the capitalization of th",{"id":670,"funder":7,"programme":8,"title":671,"piName":10,"institution":572,"country":520,"year":13,"amount":672,"abstract":673},"cordis-european-research-council-award-101125993","Not Knowing in Deep Representation Learning","€1,999,114","Machine learning and artificial intelligence techniques are progressing at a tremendous pace and impressive results appear across scientific fields. However, as machine learning models grow in capacity, they become increasingly ‘black box’, and it becomes harder for humans to reason about the patterns discovered by the machine. A root cause of this difficulty is that most machine learning models can express the same pattern in infinitely many, equally good, ways within their internal representat",{"id":675,"funder":7,"programme":8,"title":676,"piName":10,"institution":572,"country":520,"year":13,"amount":677,"abstract":678},"cordis-european-research-council-award-101126182","The Quest for MAGNetIc Fields in A and F TYpe Stars","€1,999,933","Magnetic fields are ubiquitous and have a substantial impact on galactic, stellar and planetary evolution and on life. Theoretical models imply that magnetic fields can affect stars from the deep interior to the outermost layers at each stage of evolution. Yet the origin, geometry and evolution of magnetic fields often remain a mystery. Consequently, standard stellar evolution models do not consider the interaction of magnetic fields with other physical processes.Extensive surveys show that only",{"id":680,"funder":7,"programme":8,"title":681,"piName":10,"institution":519,"country":520,"year":13,"amount":21,"abstract":682},"cordis-european-research-council-award-101126220","Repair mechanisms of topoisomerase II DNA lesions","Topoisomerase II (TOP2) chemotherapeutics such as etoposide have been widely used in the clinic to treat leukemias, lymphomas, lung, testicular, and ovarian cancers. Etoposide was first approved for clinical usage in 1983. By intercalating into DNA, etoposide stalls the TOP2 catalytic cycle, generating toxic DNA lesions known as TOP2-DNA-protein crosslinks (TOP2-DPCs). After 40 years of intense research, the mechanisms employed by cells that counteract these lesions are starting to emerge. These",{"id":684,"funder":7,"programme":8,"title":685,"piName":10,"institution":519,"country":520,"year":13,"amount":686,"abstract":687},"cordis-european-research-council-award-101124391","New isotope tracers of rocky planet forming environments","€1,970,878","The plethora of Earth-like exoplanets indicate that planet-formation is efficient, highlighting the need for unravelling the pathways to forming habitable worlds. The new planet-formation paradigm, i.e. pebble accretion, suggests that mm-to-cm sized pebbles are the main planetary building blocks as opposed to colliding proto-planetary bodies. Bulk samples of meteorites from asteroids, leftovers from the early Solar System, have been long used to infer the nature of Earth’s precursor material. Ho",{"id":689,"funder":7,"programme":8,"title":690,"piName":10,"institution":519,"country":520,"year":13,"amount":691,"abstract":692},"cordis-european-research-council-award-101125652","Algebraic Formula Lower Bounds and Applications","€1,869,055","Does efficient verification imply efficient search? Can randomness provide massive speed-ups in computation? These are fundamental questions in theoretical computer science, known as P vs. NP and P vs. BPP respectively. Progress on these questions requires us to to show that certain computational problems are inherently intractable, i.e. do not admit efficient solutions. An important, and concrete, approach to such questions is to understand the complexity of algebraic problems such as the Deter",{"id":694,"funder":7,"programme":8,"title":695,"piName":10,"institution":519,"country":520,"year":13,"amount":21,"abstract":696},"cordis-european-research-council-award-101124807","The multiple LAYERS of childhood adversity","Health inequality is a major societal challenge, and evidence suggests that health inequality is established in childhood and may even transcend generations. Childhood is a sensitive period with rapid growth and development, and adversity during this period may have long-lasting health effects. More importantly, multiple forms of adversity intersect with each other, and disadvantaged children are often exposed to adversity across multiple biological, health, social, neighbourhood and environment",{"id":698,"funder":7,"programme":8,"title":699,"piName":10,"institution":519,"country":520,"year":13,"amount":700,"abstract":701},"cordis-european-research-council-award-101125362","Non-canonical modification of viral RNA","€1,996,986","Viruses cause significant disease, exemplified by the COVID-19 pandemic. Most studies of virus-host interactions focused on proteins, however, RNA holds great promise for basic and therapeutic exploration. Viruses evolved elaborate strategies for RNA protection, including 5’ capping and internal modification. The goal of this proposal is to discover and characterize viral RNA modifications installed by viral enzymes, including their role in innate immune evasion. This could uncover novel RNA-bas",{"id":703,"funder":7,"programme":8,"title":704,"piName":10,"institution":628,"country":95,"year":13,"amount":21,"abstract":705},"cordis-european-research-council-award-101125306","Fighting Pandemics from Below. Global North-South Public Health Cooperation in the Middle East and North Africa, 1792-1942","This project will recapture the lost archives and historical knowledge of international public health cooperation between the global north and the global south by analysing its first and longest-lasting instances: the sanitary councils in the Middle East and North Africa (MENA). Established in Tangier, Alexandria, Tunis, Istanbul and Tehran, these unprecedented institutions strategised against waves of epidemics and pandemics between the 1790s and the 1940s. Their European, American and native c",{"id":707,"funder":7,"programme":8,"title":708,"piName":10,"institution":709,"country":83,"year":13,"amount":710,"abstract":711},"cordis-european-research-council-award-101124921","Generating Unstable Dynamics in dispersive Hamiltonian fluids","SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE","€1,444,033","This project aims to prove rigorous results on the generation of unstable dynamics in the dispersive Hamiltonian water waves and geophysical fluid equations: I refer to the outstanding open problems of the formation of energy cascades from low to high frequencies, orbital instabilities and extreme rare phenomena such as rogue waves. All these behaviors are well documented in experiments, real world data and numerical simulations, but still lack a rigorous mathematical proof. Accordingly the proj",{"id":713,"funder":7,"programme":8,"title":714,"piName":10,"institution":715,"country":135,"year":13,"amount":716,"abstract":717},"cordis-european-research-council-award-101044374","Filling the Behavioral Gap in Disaster Risk Reduction and Climate Change Adaptation","ECOLE POLYTECHNIQUE","€1,998,950","Do only foolish people drown and only compulsive gamblers suffer flood losses? Conventional wisdom is based on flawed underlying assumptions and the EU vision of a disaster- and climate-resilient society cannot be achieved by relying on behaviour-blind assessments and policy. Whilst the behaviour of individuals, businesses and public services before, during and after a crisis has a significant impact on damages, recovery and resilience, current assessments fail to include such critical factors b",{"id":719,"funder":7,"programme":8,"title":720,"piName":10,"institution":158,"country":159,"year":13,"amount":721,"abstract":722},"cordis-european-research-council-award-101125746","Next-generation engineering of gas-fermenting cell factories through large-scale systems-level maps","€2,330,500","Gas fermentation provides a unique opportunity for the circular bioeconomy by enabling carbon recycling from gaseous waste feedstocks into value-added bioproducts using microbes. Acetogens are ideal biocatalysts for gas fermentation as they use gas (CO and\u002For CO2+H2) as their sole carbon and energy source, evidenced by the commercialisation of the waste gas-to-ethanol conversion process. Despite recent efforts, our understanding of genotype-phenotype relationships in acetogens is still minimal. ",{"id":724,"funder":7,"programme":8,"title":725,"piName":10,"institution":726,"country":228,"year":13,"amount":727,"abstract":728},"cordis-european-research-council-award-101124488","Machine Learning and Mass Spectrometry for Structural Elucidation of Novel Toxic Chemicals","STOCKHOLMS UNIVERSITET","€1,867,187","Nearly half a million known chemicals have been deemed relevant for exposure studies and an even larger number of their transformation products are likely to co-occur in the environment. This mind-blowing number of possible chemical structures makes it impossible to in-silico generate all these structures, let alone synthesise and analytically confirm them, thereby limiting the discovery of novel chemicals. Today, the structural elucidation of chemicals detected with high resolution mass spectro",{"id":730,"funder":7,"programme":8,"title":731,"piName":10,"institution":732,"country":95,"year":13,"amount":21,"abstract":733},"cordis-european-research-council-award-101124787","RNA structure ensemble dynamics in living cells","RIJKSUNIVERSITEIT GRONINGEN","Ribonucleic acid (RNA) is a Ribonucleic acid (RNA) is a jack-of-all-trades. It orchestrates and contributes to a multitude of essential cellular processes, both under physiological and pathological conditions. Among these, transcriptional and post-transcriptional regulation of gene expression, splicing, and translation control.Many of the functions of RNA rely on its ability to fold into stable secondary structures. However, RNA structures are far from being static. Indeed, for a given RNA, mult",{"id":735,"funder":7,"programme":8,"title":736,"piName":10,"institution":737,"country":445,"year":13,"amount":738,"abstract":739},"cordis-european-research-council-award-101124500","Impact of foreshock transients on near-Earth space","HELSINGIN YLIOPISTO","€1,998,084","This project addresses major open questions in plasma physics: the dynamics of collisionless shocks, their impact on the downstream medium and particle acceleration. Collisionless shocks are powerful particle accelerators, ubiquitous in astrophysical plasmas. Recent works suggest that the dynamics of the shock precursor, or foreshock, contributes greatly to shock acceleration. Here we use near-Earth space as a natural laboratory to quantify the impact of transient kinetic structures forming in t",{"id":741,"funder":7,"programme":8,"title":742,"piName":10,"institution":194,"country":20,"year":13,"amount":743,"abstract":744},"cordis-european-research-council-award-101124221","Deciphering the role of surface mechanics during cell division","€2,200,287","Cell division is fundamental for all life forms and its dysregulation can lead to severe diseases including cancer. The dramatic shape changes eukaryotic cells have to undergo to divide are mostly driven by the cell surface, a complex system that can dynamically modify its mechanical properties. While the importance of physical cues for cell division has long been recognized, the lack of specific tools that modify particular physical properties and bridge molecular-to-cellular scale biophysics p",{"id":746,"funder":7,"programme":8,"title":747,"piName":10,"institution":748,"country":27,"year":13,"amount":749,"abstract":750},"cordis-european-research-council-award-101126235","A Data-driven Approach to Microstructural Imaging","UNIVERSITEIT ANTWERPEN","€1,999,706","The ability to study tissue microstructure in vivo and completely noninvasively using magnetic resonance imaging (MRI) has the potential to radically change how we detect, monitor, and treat diseases, in particular the many neurodegenerative diseases that affect our world’s aging population. Unfortunately, the MRI signal is a very indirect measure of microstructure, and the variety of contributing factors complicates a one-to-one association between the MRI measurements and the biological substr",{"id":752,"funder":7,"programme":8,"title":753,"piName":10,"institution":754,"country":382,"year":13,"amount":548,"abstract":755},"cordis-european-research-council-award-101122542","Deep-sea fish vision pushing limits of the vertebrate eye","UNIVERZITA KARLOVA","Deep-sea fishes are known for extraordinary adaptations including enhanced sensory systems. They have eyes often modified in shape, anatomy or at the molecular level. Fascinatingly, some deep-sea fishes have evolved unique vision to potentially see colours. Here I propose to study functional evolution of this visual system, and to target the crucial question – can deep-sea fish see in colours? To perceive light, vertebrate retina has two types of photoreceptor cells, the rods for dim-light visio",{"id":757,"funder":7,"programme":8,"title":758,"piName":10,"institution":588,"country":20,"year":13,"amount":21,"abstract":759},"cordis-european-research-council-award-101124892","Perceptual functions of Drosophila retinal movements and the underlying neuronal computations","Sensory perception is often an active process, and many animals move their sensory organs to actively shape their interactions with the outside world. Active sensing can provide animals with important information that impacts their survival and overall fitness. We recently found that Drosophila adjust their visual input by moving their retinas underneath the stationary lenses of the compound eye. The discovery of retinal movements in the fly provides us with a fantastic toolbox to study the cell",{"id":761,"funder":7,"programme":8,"title":762,"piName":10,"institution":737,"country":445,"year":13,"amount":763,"abstract":764},"cordis-european-research-council-award-101122047","A Foundation for Empirical Multimodality Research","€1,999,974","This project lays a foundation for conducting data-driven empirical research on multimodality, that is, how human communication and interaction rely on combinations of 'modes' of expression. Theories of multimodality are rapidly gaining currency in diverse fields concerned with human communication, interaction and cultural production. However, most theories of multimodality are based on conjecture and remain without an empirical foundation due to the lack of large, richly-annotated multimodal co",{"id":766,"funder":7,"programme":8,"title":767,"piName":10,"institution":457,"country":20,"year":13,"amount":768,"abstract":769},"cordis-european-research-council-award-101125503","Linked Lives: Consequences of Long Commuting for the Health of All Family Members","€2,193,224","Passive commuting–regularly recurring travel between home and work by a motorized vehicle or public transportation–is an integral part of our lives. Commuting may take a toll on the health of commuters and their family members. Current research offers a limited understanding of whether commuting’s health impacts are socially patterned. Information about whether long commuting affects family members is scarce. A comprehensive inquiry into this topic is needed to understand what commuting means fo",{"id":771,"funder":7,"programme":8,"title":772,"piName":10,"institution":737,"country":445,"year":13,"amount":773,"abstract":774},"cordis-european-research-council-award-101125261","What doesn’t kill you: primed and adaptive mechanisms of treatment resistance in ovarian cancer","€1,999,754","Cancer therapy resistance is a complex, dynamic process. Pre-existing heterogeneity in cell states provides substance for evolutionary selection, and their plasticity enables adaptation during the therapy. Recently, we discovered a stress-related, immunocompromised cell state underpinning both intrinsic and adaptive resistance in high-grade serous ovarian cancer (HGSC) metastatic tumours, suggesting that pre-existing stress improves the resilience of cancer cells during neoadjuvant chemotherapy.",{"id":776,"funder":7,"programme":8,"title":777,"piName":10,"institution":737,"country":445,"year":13,"amount":778,"abstract":779},"cordis-european-research-council-award-101125874","Whose sustainability? Understanding and redefining just sustainability transformations through disability and queer perspectives","€1,961,250","A major adagio of the Sustainable Development Goals is “Leave no one behind” implying that actions addressing the sustainability challenges of our time should not be only ecologically beneficial, but also emancipatory for the most vulnerable and marginalized. Yet, many vulnerable and marginalized groups are often left behind in sustainability research and actions. Despite the increasing engagement of disabled and queer scholars and societal actors for environmental and climate justice, their voi",{"id":781,"funder":7,"programme":8,"title":782,"piName":10,"institution":726,"country":228,"year":13,"amount":783,"abstract":784},"cordis-european-research-council-award-101126144","Agricultural Productivity and Technology Adoption in Sub-Saharan Africa","€1,575,812","Agricultural productivity is strikingly low in much of Sub-Saharan Africa, exposing the large fraction of the population who lives from agriculture to low incomes and periods of hunger. Despite high returns to modern agricultural inputs elsewhere, their adoption in the region has been persistently low over the past decades. In the absence of adaptation, climate change is expected to severely impact the agricultural productivity of Sub-Saharan Africa. I propose three projects which will significa",{"id":786,"funder":7,"programme":8,"title":787,"piName":10,"institution":726,"country":228,"year":13,"amount":141,"abstract":788},"cordis-european-research-council-award-101125269","Healing societies: The impact of social context on intergroup reconciliation","The recent increase in intergroup conflicts emphasize the importance of finding ways how to reconcile members of adversary groups. Subsequently, social psychologists have developed evidence-based reconciliation interventions aimed at improving intergroup attitudes and behaviours towards outgroups. Even though intervention effectiveness and outcomes depend on the context in which people live, most empirical research on reconciliation interventions has ignored the impact of the social context. The",{"id":790,"funder":7,"programme":8,"title":791,"piName":10,"institution":792,"country":95,"year":13,"amount":41,"abstract":793},"cordis-european-research-council-award-101125393","Understanding malignant transformation of precancerous lesions in human colon","PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV","A crucial milestone in tumor progression is the transformation from a benign adenoma to a malignant cancer, which has profound impact on clinical outcome and therapy design. Despite its importance, it is poorly understood why it manifests itself as a bottleneck that can restrain precancerous adenomas for years. While recent sequencing efforts inform ‘static’ insights into the status of cancer genomes, these are incomplete to infer how they evolved, assess functional consequence of mutations, nor",{"id":795,"funder":7,"programme":8,"title":796,"piName":10,"institution":797,"country":12,"year":13,"amount":798,"abstract":799},"cordis-european-research-council-award-101125484","Global Amyloid Mapping: Solving Amyloid Nucleation by Deep Mutagenesis","FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA","€1,999,008","Amyloid fibrils form and precipitate in more than 50 incurable human diseases, including Alzheimer’s and Parkinson’s disease. All proteins may be able to form amyloids, at least under certain circumstances. However, aggregation is actually rare as the process of amyloid formation is controlled by a high kinetic barrier: protein sequences have to cross a free energy barrier to nucleate transition states which then seed irreversible fibril formation. Short-lived transition states are extremely cha",{"id":801,"funder":7,"programme":8,"title":802,"piName":10,"institution":732,"country":95,"year":13,"amount":803,"abstract":804},"cordis-european-research-council-award-101125957","Continuous Enzyme Evolution – solving bottlenecks in enzyme engineering to design next-generation biocatalysts","€1,999,991","Directed evolution has revolutionized the application of enzymes in industrial settings by allowing users to tailor the properties and activities of biocatalysts to their needs. But classic directed evolution is notoriously labor- and time-intensive, as it manually stages mutation, selection, and amplification cycles. In contrast, continuous evolution (CE) approaches aim to achieve these steps within a replicating organism, making it possible to engineer efficient enzymes in a matter of days rat",{"id":806,"funder":7,"programme":8,"title":807,"piName":10,"institution":808,"country":83,"year":13,"amount":809,"abstract":810},"cordis-european-research-council-award-101125923","Quantum-enhanced nonlinear imaging","UNIVERSITA DEGLI STUDI DELL'INSUBRIA","€1,979,704","Many pioneering advances in medicine and biology require observation of the microscopic world with high resolution and without damaging the specimen. One of the most widespread techniques is multiphoton fluorescence microscopy, which allows full 3D imaging via optical sectioning, i.e., imaging of planes within the sample without the need for physical slicing. This technique has a major limitation, however: the penetration depth and the signal-to-noise ratio are not sufficient for imaging deep wi",{"id":812,"funder":7,"programme":8,"title":813,"piName":10,"institution":814,"country":228,"year":13,"amount":21,"abstract":815},"cordis-european-research-council-award-101124440","SAfeguarding female FERtility -development of human-relevant in vitro tools for reproductive toxicity","KAROLINSKA INSTITUTET","Chemical health risk assessment has failed to safeguard fertility in women. Women and their oocytes are exposed to pervasive mixtures of human-made chemicals that correlate with reproductive ageing and infertility. Only 0.5% of the chemicals on the European market have been well characterized for health risks, and reproductive toxicity in women is typically not covered due to missing tools. The new European Growth Strategy aims at sustainable growth, zero-pollution and safe chemicals. While the ",{"id":817,"funder":7,"programme":8,"title":818,"piName":10,"institution":129,"country":111,"year":13,"amount":819,"abstract":820},"cordis-european-research-council-award-101126170","Stimuli responsive bio-based bisphenols for the synthesis of recyclable thermosets","€1,999,271","Thermosets are an intriguing class of polymeric materials characterized by high durability and excellent thermal stability, indispensable in many industrial sectors such as construction, transportation and aviation. However, due to precisely these sought-after characteristics, they are typically not recycled, contributing to raising environmental concerns. Moreover, thermosets are typically manufactured from unsustainable, petrol-derived Bisphenol-A.StimulART will tackle the two key scientific c",{"id":822,"funder":7,"programme":8,"title":823,"piName":10,"institution":26,"country":27,"year":13,"amount":824,"abstract":825},"cordis-european-research-council-award-101126114","Molecular and Functional Characterisation of Z-nucleic Acid-induced Signalling","€1,983,531","Nucleic acids are potent activators of an immune response. Z-nucleic acids are poorly defined and thermodynamically unstable conformers of double-stranded RNA\u002FDNA helices. Recently, others and our group showed that Z-nucleic acids are recognised by the nucleic acid sensor ZBP1, thereby inducing an antiviral immune response. Activation of ZBP1 has also been shown to induce anticancer immunity and it is becoming clear that chronic engagement of ZBP1 by endogenous Z-nucleic acids causes autoinflamm",{"id":827,"funder":7,"programme":8,"title":828,"piName":10,"institution":211,"country":95,"year":13,"amount":21,"abstract":829},"cordis-european-research-council-award-101122863","Learning the dynamic statistical folding of bacterial chromosomes","The physical organization of bacterial chromosomes is inherently variable, with large conformational fluctuations both from cell to cell and over time. Yet, chromosomes must also be structured to facilitate processes such as transcription, replication, and segregation. A physical description of this dynamic statistical folding of bacterial chromosomes remains largely elusive.  Hi-C experiments probe chromosome organization by measuring average contact frequencies of chromosomal loci pairs. Despi",{"id":831,"funder":7,"programme":8,"title":832,"piName":10,"institution":833,"country":111,"year":13,"amount":834,"abstract":835},"cordis-european-research-council-award-101124404","Understanding of the Membrane Connection Linking the Nucleus to the Endoplasmic Reticulum","MEDIZINISCHE UNIVERSITAET WIEN","€1,995,843","Compartmentalization into membrane-bound organelles is a key feature of all eukaryotic cells, and communication between organelles needs to be tightly controlled. A key organelle for the inter-organelle communication is the endoplasmic reticulum (ER), which is the major site of lipid and membrane protein synthesis. The ER exchanges molecules by forming stable contact sites with multiple organelles such as mitochondria via specific tethering proteins and transporters. In contrast to these contact",{"id":837,"funder":7,"programme":8,"title":838,"piName":10,"institution":839,"country":20,"year":13,"amount":840,"abstract":841},"cordis-european-research-council-award-101125599","Group 1 and Group 2 Metal-Metal Bonds. Tailored Reduction Reagents in Synthesis and Catalysis.","UNIVERSITAT DES SAARLANDES","€1,998,966","The increasing demand for environmentally friendly reagents to perform sustainable processes has become of paramount relevance for modern academia and industry. Transition metal-based catalysts are long-established players in many important chemical transformations, given their ability to cleave and form chemical bonds with facile oxidation state changes. Their high cost and\u002For toxicity, however, have prompted the search for potential replacements. The past decades brought fascinating discoverie",{"id":843,"funder":7,"programme":8,"title":844,"piName":10,"institution":557,"country":111,"year":13,"amount":845,"abstract":846},"cordis-european-research-council-award-101125295","Heterogeneous Asymmetric Nanocluster-catalysis Design","€1,993,224","Chirality plays a major role in several areas due to the different behavior of each enantiomeric form of a compound, critical in the pharmaceutical industry. Obtaining pure enantiomers is one of the most difficult challenges, in which homogeneous asymmetric catalysis has achieved significant steps. Now it is time to undertake the challenge by heterogeneous enantioselective catalysis, implying great advantages in terms of sustainability, and offers further opportunities for in-depth understanding",{"id":848,"funder":7,"programme":8,"title":849,"piName":10,"institution":850,"country":95,"year":13,"amount":21,"abstract":851},"cordis-european-research-council-award-101122484","Creating Knowledge","STICHTING RADBOUD UNIVERSITEIT","In this project I want to unravel how we build-up and update our knowledge networks depending on the amount of previous experience we have by testing my new theory on experience dependent learning. Current theory postulates memories to be stored initially as sets of neural representations spanning the hippocampus and weakly interacting neocortical modules. The spontaneous reactivation of new memories during a consolidation phase, would lead to strengthening of the neocortical memory trace. Conse",{"id":853,"funder":7,"programme":8,"title":854,"piName":10,"institution":855,"country":228,"year":13,"amount":21,"abstract":856},"cordis-european-research-council-award-101124329","Controlling delocalisation and funnelling of excited state energy in the strong coupling regime in molecular systems","GOETEBORGS UNIVERSITET","A fundamental physical property of A fundamental physical property of matter is its ability to interact with light. This is not only the basis of fascinating concepts like seeing colours, but also the foundation of life and advanced technologies. Yet, some basic physical laws hamper possible utilisations. It is therefore of great importance to examine how to bend these laws, how to bypass them and by so doing open up new opportunities for novel applications. This is exactly what this project aim",{"id":858,"funder":7,"programme":8,"title":859,"piName":10,"institution":860,"country":20,"year":13,"amount":112,"abstract":861},"cordis-european-research-council-award-101125870","Tuning TDP-43 self-assembly to understand physiological function and dysfunction","JOHANNES GUTENBERG-UNIVERSITAT MAINZ","Neurodegenerative disorders are an enormous societal burden and we lack therapies that target these diseases at their origins. To develop therapies, we need to understand what goes wrong at the molecular level. I uncovered key mechanisms that cause RNA-binding proteins, such as TDP-43, to dysfunction and drive neurodegenerative processes. I discovered that RNA-binding proteins self-assemble into ribonucleoprotein granules that are the likely origins of RNA-binding protein aggregates. More recent",{"id":863,"funder":7,"programme":8,"title":864,"piName":10,"institution":649,"country":445,"year":13,"amount":865,"abstract":866},"cordis-european-research-council-award-101124827","The role of the gut microbiome in host responses to environmental variation: within and across generations and species","€1,999,943","The gut microbiome is strongly linked to health and sickness. A current key challenge is to understand how the microbiome helps the host adapt to environmental variation. Yet, most research originates from few laboratory animal models and thus misses large parts of environmental, physiological and life-history variation, while data from wild populations and species is needed. Thus, our overarching aim is to unravel how the microbiome mediates hosts responses to environmental variation, covering ",{"id":868,"funder":7,"programme":8,"title":869,"piName":10,"institution":870,"country":667,"year":13,"amount":871,"abstract":872},"cordis-european-research-council-award-101125820","Regenerative Stenting for Osteoporotic Vertebral Fracture Repair","ROYAL COLLEGE OF SURGEONS IN IRELAND","€2,039,473","Osteoporotic vertebral fractures (OVFs) are the most common complication of osteoporosis. Current treatment involves conventional procedures that inject cement into the vertebrae to stabilise the spine and relieve pain. No reparative treatment exists. Biomaterial-based treatments have had very limited success due to a number of complex challenges, such as providing dual therapeutic and mechanical functionalities to meet clinical requirements. Building on a wealth of experience in the area of mat",{"id":874,"funder":7,"programme":8,"title":875,"piName":10,"institution":876,"country":228,"year":13,"amount":877,"abstract":878},"cordis-european-research-council-award-101125879","In-operando growth of organic mixed ionic-electronic conductors for brain-inspired electronics","LINKOPINGS UNIVERSITET","€1,999,980","The development of advanced brain-computer interfaces, wearable and implantable bioelectronic devices, prosthetics, and soft robotics requires the ability to process signals in a highly individualized and localized manner. To achieve this, new materials and devices must be developed that can sense their surroundings, process information locally, and translate it into a format our body can interpret. Currently, (bio-)electronic devices rely on remote and energy-intensive cloud processing, but ele",{"id":880,"funder":7,"programme":8,"title":881,"piName":10,"institution":882,"country":20,"year":13,"amount":883,"abstract":884},"cordis-european-research-council-award-101125761","Material Decomposition in X-ray Phase-Contrast Imaging with Coherent Sources","TECHNISCHE UNIVERSITAET MUENCHEN","€2,620,750","X-ray microtomography is increasingly popular at synchrotron sources worldwide. The high flux and excellent beam properties allow for a fast three-dimensional visualization of various kinds of specimens at micrometre spatial resolution and exceptionally high image quality. But all these imaging instruments use the unique synchrotron sources merely to depict the objects’ internal structure. All further quantitative information encoded into the data remains unused. The reason is a lack of an image",{"id":886,"funder":7,"programme":8,"title":887,"piName":10,"institution":888,"country":520,"year":13,"amount":889,"abstract":890},"cordis-european-research-council-award-101124977","Decentralized Cryptographic Systems","AARHUS UNIVERSITET","€1,998,351","Much of our digital infrastructure still relies on centralized systems, which are prone to failure and, more importantly, present appealing targets for criminals and other ill-intentioned parties. A successful attack on a centralized system can have huge repercussions in terms of loss of confidentiality, integrity and availability of data and services: alas, once private data leaks, it is impossible to put it back into the confidential domain. The fragility of centralized systems is one of the r",{"id":892,"funder":7,"programme":8,"title":893,"piName":10,"institution":888,"country":520,"year":13,"amount":894,"abstract":895},"cordis-european-research-council-award-101124619","Exposing Hidden Electronic Configurations in Atomically Thin Superstructures with Extreme Light","€1,999,899","Light-induced phase transitions in solids present a tantalizing opportunity for controlling the constituents of matter. An intense optical excitation with a duration on the order of femtoseconds can trigger nonthermal electronic and structural configurations, switching the excited material into a hidden phase that may be exploited to realize new technologies such as ultrafast memory devices. A general picture of the microscopic processes underpinning hidden phases has not been established. Their",{"id":897,"funder":7,"programme":8,"title":898,"piName":10,"institution":506,"country":83,"year":13,"amount":899,"abstract":900},"cordis-european-research-council-award-101124288","Doping Compensation in Thin Silicon Sensors: the pathway to Extreme Radiation Environments","€1,800,926","Silicon sensors have been extensively exploited in high-energy physics experiments in the past 40 years, from their first use in NA11 at the SPS (CERN) to their application in the present-day design of very large particle trackers. The capability of silicon sensors to work in environments with high radiation levels has been of utmost importance for experiments at accelerating machines with very energetic and intense particle beams. Presently available silicon sensors can operate efficiently up t",{"id":902,"funder":7,"programme":8,"title":903,"piName":10,"institution":666,"country":667,"year":13,"amount":904,"abstract":905},"cordis-european-research-council-award-101124603","Regulation of Articular Cartilage Zonal Emergence:  Harnessing Developmental Pathways to Enhance Regeneration","€2,265,746","Articular cartilage (AC) has a complex zonal structure and composition, providing it with its essential functional properties. However, when cartilage is damaged, the zonal complexity does not regenerate, leaving an inferior tissue which is prone to degeneration. As a result, cartilage injury commonly leads to pain and the eventual need for joint replacement. Progress towards true regeneration of AC requires an advance in understanding of how zonal complexity (and corresponding function) emerge ",{"id":907,"funder":7,"programme":8,"title":908,"piName":10,"institution":146,"country":20,"year":13,"amount":909,"abstract":910},"cordis-european-research-council-award-101124718","Investigate maternal and paternal risk factors for violence during pregnancy: lasting impact for everyone","€1,999,924","Globally, one in three women are estimated to experience physical and\u002For sexual intimate partner violence during their lifetime. Pregnancy is a life-changing time, when violence might subside, occur for the first time or intensify. Abuse and its consequences can be severe for both mother and children, and cascade into the next generation.IMPROVE_LIFEs aim is to understand the risk and protective factors for violence during pregnancy, its short and long-term effects and intergenerational impact.T",{"id":912,"funder":7,"programme":8,"title":913,"piName":10,"institution":914,"country":20,"year":13,"amount":915,"abstract":916},"cordis-european-research-council-award-101124492","Cavity quantum materials","UNIVERSITAET BREMEN","€1,951,063","Light-matter coupling has the potential to modify functional properties of quantum materials to yield the tunability required for quantum-technological applications. However, light-matter control concepts, such as Floquet engineering and light-induced phase transitions, suffer from the requirement of strong laser driving and the lack of coherence on long time scales. Overcoming these key limitations through advancing the infant field of cavity quantum materials is the central objective of CAVMAT",{"id":918,"funder":7,"programme":8,"title":919,"piName":10,"institution":563,"country":95,"year":13,"amount":21,"abstract":920},"cordis-european-research-council-award-101124621","ENTANGLED FREEDOMS: Decolonial Modernisms as Transnational Relations of Resistance, 1940s-1980s","ENTANGLEDFREEDOMS studies how practices and discourses of artistic modernism from the decolonizing worlds of Asia, Africa, and the Middle East entangled with plural and contesting notions of freedom during 20th-century decolonization and Cold War. Taking scopes of ‘freedom’ out of hegemonic Cold War binaries of western ‘First World’ vs. socialist ‘Second World’ values, I read it instead, in dialogue with its resonant global vocabularies of independence\u002Fliberation\u002Femancipation, and via visual art",{"id":922,"funder":7,"programme":8,"title":923,"piName":10,"institution":924,"country":20,"year":13,"amount":925,"abstract":926},"cordis-european-research-council-award-101126140","Tau, a molecular modulator of neuronal energy managment","DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV","€2,194,940","The intraneuronal somatodendritic missorting and aggregation of Tau are pathological hallmarks in neurodegenerative diseases (NDDs) like and Alzheimer's disease (AD), and are thought to be drivers of neurotoxicity. That NDDs manifesting with Tau missorting present with (neuro)metabolic abnormalities, often prior to pathology onset, is largely overlooked. EnergizeTau investigates the ground-breaking new idea that the somatodendritic re-sorting of Tau is a physiological response to bioenergetic ch",{"id":928,"funder":7,"programme":8,"title":929,"piName":10,"institution":930,"country":83,"year":13,"amount":931,"abstract":932},"cordis-european-research-council-award-101126135","Vascular Control of NASH Progression","UNIVERSITA VITA-SALUTE SAN RAFFAELE","€1,741,250","Non-alcoholic steato-hepatitis (NASH) is a major risk factor for hepatocellular carcinoma (HCC), the 6th most common cause of cancer-related death worldwide. The transition among different NASH stages to HCC stems from the complex interaction of multiple factors, including gut-liver axis modifications and a progressive dis-architecture of the liver parenchyma.The central role of endothelial cells in regulating the metabolic crosstalk along the gut-liver axis and in shaping the spatial organizati",{"id":934,"funder":7,"programme":8,"title":935,"piName":10,"institution":936,"country":595,"year":13,"amount":937,"abstract":938},"cordis-european-research-council-award-101126019","Limited proteolysis mechanisms in plants for selective protein translation to improve heat tolerance","IDRYMA TECHNOLOGIAS KAI EREVNAS","€1,908,375","Heat waves threaten agriculture in the EU and worldwide. Exactly how we can protect our crops precisely and rapidly from heat is a lingering question with important implications for future food security. My aim with PLANTEX is to explore the potential of a rapid stress response that my lab has discovered and incorporate this knowledge into the design of new breeding strategies to improve crops. To bolster heat tolerance, I propose an innovative approach for the control of protein production netw",{"id":940,"funder":7,"programme":8,"title":941,"piName":10,"institution":942,"country":667,"year":13,"amount":803,"abstract":943},"cordis-european-research-council-award-101125633","Enabling personalised diagnosis, treatment, and stratification through whole-body metabolic modelling of an individual’s genome, metabolome, and metagenome.","UNIVERSITY OF GALWAY","The increasing availability of whole-genome sequences will ultimately transform medicine into personalised medicine. To realise this potential, we need to understand which of the millions of genetic variants in a person’s genome can alter a phenotype. Genome-wide association studies (GWAS) have associated many genetic variants with thousands of phenotypic traits. Metabolomics has further informed GWAS. However, these methods do generally not consider the biochemical network connecting genetic va",{"id":945,"funder":7,"programme":8,"title":946,"piName":10,"institution":346,"country":20,"year":13,"amount":947,"abstract":948},"cordis-european-research-council-award-101125551","Leveraging the impact of gut microbes to advance the efficacy of CAR-T cell immunotherapy.","€1,999,819","T cell therapy with chimeric antigen receptor (CAR)-T cells is a curative-intent, transformative treatment aimed to boost antitumor abilities of host T cells against refractory\u002Frelapsed B cell malignancies and, recently, against refractory\u002Frelapsed myeloma. Major challenges of current CAR-T cell immunotherapies are the loss of long-term efficacy, the occurrence of toxicities including infections, and a lack of personalized patient strategies including biomarkers for response prediction and inter",{"id":950,"funder":7,"programme":8,"title":951,"piName":10,"institution":952,"country":27,"year":13,"amount":953,"abstract":954},"cordis-european-research-council-award-101125902","Drug DELIvery to the brain via CHOroid Plexus targeting","VIB VZW","€1,999,756","CNS disorders, e.g. brain cancer and Alzheimer’s disease, are the most common, debilitating, and underserved diseases. CNS drugs have historically suffered from considerably lower success rates during development than those for non-CNS indications. One of the major reasons is the presence of CNS barriers, including the blood-brain (BBB) and blood-cerebrospinal fluid (CSF) barrier. These blood-brain interfaces severely restrict the cerebral bioavailability of pharmaceutical compounds. While numer",{"id":956,"funder":7,"programme":8,"title":957,"piName":10,"institution":958,"country":95,"year":13,"amount":21,"abstract":959},"cordis-european-research-council-award-101125814","Foundation models for molecular diagnostics - machine learning with biological ‘common sense’","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","Molecular diagnostics is crucial in fulfilling the promise of personalized medicine. While we are amidst an AI revolution, current machine learning models (ML) struggle to effectively learn from molecular (‘omics’) patient profiles and fail to make robust predictions. Perhaps this is not a surprise. After all, molecular disease biology is immensely complex, and we ask ML models to predict such complicated things as patient prognosis, without them ‘knowing’ anything about molecular biology and ba",{"id":961,"funder":7,"programme":8,"title":962,"piName":10,"institution":104,"country":95,"year":13,"amount":963,"abstract":964},"cordis-european-research-council-award-101126124","Synthetic Chimeric Antigen Receptors: Hijacking Nitrenium Ions for Targeting, Therapy and Safety of Next Generation T Cell Therapy","€2,501,154","Chimeric antigen receptor (CAR) T cell therapy is a promising approach for cancer treatment with remarkable clinical outcomes. CAR T therapy involves the isolation of patients T cells that are genetically modified with an engineered antigen receptor to attack cancer cells.Despite the great promise, the rapid activation and proliferation of CAR T cells can lead to serious side effects. In addition, CAR T therapy is challenged by limited effectiveness, difficulties in infiltrating solid tumors, ta",{"id":966,"funder":7,"programme":8,"title":967,"piName":10,"institution":536,"country":228,"year":13,"amount":21,"abstract":968},"cordis-european-research-council-award-101124944","Decoding and Targeting Treatment-Resistant Metastatic Neuroblastoma","The childhood cancer neuroblastoma (NB) is a major challenge in pediatric oncology, and children with relapse have a very poor prognosis due to treatment-resistance at metastatic sites. There is an urgent need to better understand NB treatment resistance to inform the design of novel therapeutic strategies. However, current models do not mimic relapsed human NB in its most common metastatic niches in the bone and bone marrow. We recently developed advanced patient-derived and humanized NB in viv",{"id":970,"funder":7,"programme":8,"title":971,"piName":10,"institution":972,"country":111,"year":13,"amount":21,"abstract":973},"cordis-european-research-council-award-101125797","Unlocking a T cell-mediated Immune response in therapy-challenged Tumors","FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH","Immuno- and targeted therapies have revolutionized the treatment of cancer patients, and more innovative therapeutics, such as KRAS inhibitors (KRASi), are entering the clinic. However, their use as monotherapies fails to achieve durable tumor control in most patients, and the development of combination therapies remains challenging without an understanding of the complex and dynamic biology that unfolds upon therapeutic challenge in the tumor microenvironment (TME). Most of our knowledge on com",{"id":975,"funder":7,"programme":8,"title":976,"piName":10,"institution":977,"country":111,"year":13,"amount":978,"abstract":979},"cordis-european-research-council-award-101124672","Olfactormativity: Exploring the Intervening Performativity of Smell","UNIVERSITAT FUR KUNSTLERISCHE UND INDUSTRIELLE GESTALTUNG LINZ","€1,739,250","Smells intervene in human experience. Used by police or military for crowd control, they are a perfidious weapon. Yet, they also offer a wealth of material for intervening arts, the exploration of which is currently gaining traction against a backdrop of climate change and the rise of sexism and racism. So far, however, research on the intervening potential of smell has remained the province of Military Sciences, with research on intervening arts focusing on the visual and the auditory, neglecti",{"id":981,"funder":7,"programme":8,"title":982,"piName":10,"institution":888,"country":520,"year":13,"amount":983,"abstract":984},"cordis-european-research-council-award-101125203","Theoretical Understanding of Classic Learning Algorithms","€1,999,288","Machine learning has evolved from being a relatively isolated discipline to have a disruptive influence on all areas of science, industry and society. Learning algorithms are typically classified into either deep learning or classic learning, where deep learning excels when data and computing resources are abundant, whereas classic algorithms shine when data is scarce. In the TUCLA project, we expand our theoretical understanding of classic machine learning, with a particular emphasis on two of ",{"id":986,"funder":7,"programme":8,"title":987,"piName":10,"institution":988,"country":12,"year":13,"amount":989,"abstract":990},"cordis-european-research-council-award-101125401","Triboelectric energy generators for self-powered medical implants","FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA","€1,998,273","Based on intense research efforts in the fields of technology development and materials science, a new generation of medical devices has flourished. But this medical technology still relies on conventional energy sources (bulky batteries). These batteries typically have shorter lifetimes than the implant itself, meaning limitations on patients´ activities, infections and additional surgeries. In an ideal scenario, active implantable medical devices (AIMDs) would be powered using integrated and f",{"id":992,"funder":7,"programme":8,"title":993,"piName":10,"institution":94,"country":95,"year":13,"amount":21,"abstract":994},"cordis-european-research-council-award-101123866","Robotic bioreactors for the longitudinal control of restorative remodelling in the human skeletal muscle","Muscle damage impairs vital functions e.g., movement, respiration. Recovery depends on the long-term interaction between neuromuscular and immune systems. If exposed to regimens of electro-mechanical stimuli, damaged muscles can remodel new structural properties over days. Inflammation at the damage site is initially needed to clear debris but if prolonged, as in many neuromuscular disorders, it may hamper structural remodeling.Rehabilitation robots such as exoskeletons and neurostimulators can ",{"id":996,"funder":7,"programme":8,"title":997,"piName":10,"institution":998,"country":20,"year":13,"amount":21,"abstract":999},"cordis-european-research-council-award-101125845","Autoxitus: Molecular mechanisms and non-cell autonomous signalling","JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN","Cells control their content by balancing its synthesis and degradation. Autophagy is a key degradation process capable of engulfing large fractions of cells, including organelles, into double-membrane vesicles called autophagosomes. These fuse with lysosomes causing degradation of their cargo. Secretory pathways, including secretory autophagy, offer an alternative option to remove unwanted materials from cells. However, mechanisms allowing the secretion of larger cellular components are still un",{"id":1001,"funder":7,"programme":8,"title":1002,"piName":10,"institution":563,"country":95,"year":13,"amount":1003,"abstract":1004},"cordis-european-research-council-award-101125536","Protein Landscapes: The political geography of the production and consumption of animal proteins","€1,999,684","Despite the devastating effects of the meat-dairy industry on climate and environment, the production and consumption of animal-based protein is at historically high levels. I refer to this as the protein paradox. Why are we collectively unable to reduce our reliance on meat and dairy? From the extant literature, we know that changing diet is difficult, especially as the consumption of meat and dairy is culturally normalized in many societies. The literature also reveals that the meat-dairy indu",{"id":1006,"funder":7,"programme":8,"title":1007,"piName":10,"institution":1008,"country":20,"year":13,"amount":1009,"abstract":1010},"cordis-european-research-council-award-101125593","Negative Regulation of Inflammatory Responses Revealed with Camelid Nanobodies","UNIVERSITATSKLINIKUM BONN","€1,997,828","The innate immune system evokes inflammation to control pathogens or damage. Sophisticated mechanisms interpret molecular triggers to activate inflammasomes or transcription of pro-inflammatory genes. While numerous autoinflammatory conditions underline the need to control inflammation, we still rely on simplistic models to understand its negative regulation. I hypothesize that an intricate signaling network interprets information to prevent or downregulate inflammation. Understanding these so f",{"id":1012,"funder":7,"programme":8,"title":1013,"piName":10,"institution":26,"country":27,"year":13,"amount":1014,"abstract":1015},"cordis-european-research-council-award-101124151","Metabolomics-driven Molecular Source Analysis for personalized medicine in children","€1,999,763","While recent advent empowered the new reality of holistic metabolic phenotyping, we are currently still unable to accurately determine the source(s) of the underlying metabolites. This is undoubtedly the main stumbling block in inferring causality to new biomarkers for disease prevention, prediction, and prognosis, particularly given the rapidly increasing burden of metabolic diseases. At the same time, conventional metabolomics methods do not meet the requirements for adoption in clinical pract",{"id":1017,"funder":7,"programme":8,"title":1018,"piName":10,"institution":451,"country":27,"year":13,"amount":1019,"abstract":1020},"cordis-european-research-council-award-101125231","Tracing the FLUX of cosmic dust arriving to Earth during the Phanerozoic","€2,631,000","For the last 4.5 billion years, extraterrestrial (ET) materials have continuously bombarded the Earth. Today, the Solar System debris that reaches the Earth’s surface is dominated by particles less than 2 mm in size, termed micrometeorites (MMs). Until recently, the established misconception was that these MMs did not survive geological timescales, limiting reconstructions of the dust flux through time that are currently based on finding rare relict mineral phases or applying geochemical tools (",{"id":1022,"funder":7,"programme":8,"title":1023,"piName":10,"institution":1024,"country":20,"year":13,"amount":1025,"abstract":1026},"cordis-european-research-council-award-101122595","Targeting the undruggable: Leveraging neomorphic DNA-binding preferences of chimeric fusion oncogenes to promote cancer suicide","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","€1,992,235","Many aggressive cancers, such as pediatric high-risk Ewing sarcoma and alveolar rhabdomyosarcoma, are fueled by and addicted to chimeric oncogenic transcription factors (OTFs). So far, all attempts to suppress these potent OTFs largely failed, wherefore they are classified as undruggable.This proposal challenges this dogma with a novel strategy to leverage, rather than to suppress, the exquisite neomorphic DNA-binding preferences of OTFs to express therapeutic genes specifically in cancer cells.",{"id":1028,"funder":7,"programme":8,"title":1029,"piName":10,"institution":1030,"country":83,"year":13,"amount":1031,"abstract":1032},"cordis-european-research-council-award-101125051","Transcriptional footprints of cancer dependency shock as a computational tool for early anti-cancer drug discovery","FONDAZIONE HUMAN TECHNOPOLE","€1,999,455","The oncogenic shock model has been introduced to describe the interplay between pro-survival and pro-apoptotic signals that follow an oncogene's inactivation and lead to cancer cell death.In my recent work, I demonstrated that identifying novel cancer dependencies through systematic computational analyses of CRISPR functional genetic screens and multi-omic data is an excellent means to discover and prioritise new anti-cancer therapeutic targets. Here, I extend the oncogenic shock concept to any ",{"id":1034,"funder":7,"programme":8,"title":1035,"piName":10,"institution":1036,"country":20,"year":13,"amount":1037,"abstract":1038},"cordis-european-research-council-award-101126146","Integrated Mechanistic Modelling and Analysis of Large-scale Biomedical Data","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","€1,854,546","Modern cancer therapeutics target signalling processes within the cancer cells and the interaction of cancer and immune cells. A comprehensive understanding of these signalling processes is therefore essential to identify drug targets, plan clinical trials, and to select suitable drugs, drug combinations and drug dosages for a specific patient. Yet, most of the available mathematical models capture only a small number of molecular species and pathways, thereby ignoring important crosstalk and fe",{"id":1040,"funder":7,"programme":8,"title":1041,"piName":10,"institution":1042,"country":95,"year":13,"amount":21,"abstract":1043},"cordis-european-research-council-award-101125516","Early detection, molecular mechanisms and therapeutic interventions in chronic kidney disease","ACADEMISCH ZIEKENHUIS GRONINGEN","The objective of ELIMINATE-CKD is to demonstrate that combining measures of kidney structure and function will strongly enhance detection of chronic kidney disease (CKD). To reach this objective, I will develop a new method to quantify the number of nephrons, the smallest functional units in the kidney.Rationale:- CKD affects ~10% of the global population and causes 2.6 million deaths\u002Fyear. CKD-associated costs (140 billion euros\u002Fyear in Europe) exceed diabetes and cancer. Limitations in CKD det",{"id":1045,"funder":7,"programme":8,"title":1046,"piName":10,"institution":146,"country":20,"year":13,"amount":21,"abstract":1047},"cordis-european-research-council-award-101124203","Cancer tailored next generation cellular therapies","Cellular therapies are commonly used to treat hematological cancers but have yet to be established in solid oncology. Their evolution has been fuelled by hypotheses derived from cell biological observations in cancer models. Most approaches, however, will either never enter clinical development or fail clinical testing, often due to inadequate models of disease and their lack of relevance to human biology.In CATACLIS, I propose the first unbiased development of cellular products based on patient",{"id":1049,"funder":7,"programme":8,"title":1050,"piName":10,"institution":1030,"country":83,"year":13,"amount":1051,"abstract":1052},"cordis-european-research-council-award-101125077","Dynamics of Adaptation and Resistance in Cancer: MApping and conTrolling Transcriptional and Epigenetic Recurrence","€1,995,582","Tumours evolve, transforming from early-stage curable disease into treatment-refractory, deadly cancer. Therapy resistance is arguably the biggest problem in oncology today, and much of it remains unexplained. The central hypothesis of this proposal is that a large proportion of unexplained drug resistance is due to heritable epigenetic alterations, and non-heritable transcriptional plasticity in cancer cells. I refer to these mechanisms as the dark matter of cancer evolution. Genetic, epigeneti",{"id":1054,"funder":7,"programme":8,"title":1055,"piName":10,"institution":1056,"country":20,"year":13,"amount":1057,"abstract":1058},"cordis-european-research-council-award-101124542","Deciphering fibrosis reversal mechanisms in chronic blood cancer for identification of novel predictive and therapeutic strategies","UNIVERSITAETSKLINIKUM AACHEN","€1,999,313","Fibrosis is estimated to be involved in 45% of global mortality, and currently no specific therapies for fibrosis in most organs exist. One central and controversially discussed question in the field of organ fibrosis is: is fibrosis truly reversible? In Rewind-MF, I will address this biologically and clinically highly relevant question in a prime example: bone marrow fibrosis in a chronic blood cancer called Primary Myelofibrosis (PMF). In PMF, hematopoietic stem cells become mutated and activa",{"id":1060,"funder":7,"programme":8,"title":1061,"piName":10,"institution":1062,"country":135,"year":13,"amount":1063,"abstract":1064},"cordis-european-research-council-award-101124255","Role of prenatal stress-induced fetal neuro-immune rewiring in susceptibility to develop pediatric eczema","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","€2,857,135","The prenatal period is a critical timeframe during which all the physiological systems of the body, including immune and sensory systems, develop their specific functions and adapt to possible incoming cues. Atopic dermatitis, also known as eczema, is the most common skin manifestation in infants and toddlers from 3 months to 2 years of age, with a very early onset during the first years of life. While genetic and immune factors play an important role, recent epidemiological studies have listed ",{"id":1066,"funder":7,"programme":8,"title":1067,"piName":10,"institution":1068,"country":135,"year":13,"amount":1069,"abstract":1070},"cordis-european-research-council-award-101088477","Private interests in public functions: Framing a new paradigm of power in the cities of the Roman Empire, from the end of the Republic to Diocletian","SORBONNE UNIVERSITE","€1,999,350","Examining the hundreds of cities which formed the basis of the Roman Empire (70 BC-AD 284), PECUNIA interrogates the material and pecuniary interests made available to local elites by their political activity. It investigates how positions in local institutions were structurally associated with private opportunities and how this phenomenon was conceived and regulated at both levels of the imperial system, i.e. the Roman centre and the cities. In the civic milieu, the flow of gifts and mandatory ",{"id":1072,"funder":7,"programme":8,"title":1073,"piName":10,"institution":1062,"country":135,"year":13,"amount":1074,"abstract":1075},"cordis-european-research-council-award-101125555","Vascular Interactions and Remodeling during Gestation and its Impact on Neuronal functions","€1,999,039","An intricate network of blood vessels perfuses the brain to support neural cells and carry signaling molecules from the periphery. It is mainly considered a rigid transportation network rather than a dynamic and plastic information network integrated to neurons and glia. This proposal revisits this concept and aims to define the nature of vascular remodeling in healthy brains (i) and which remodeling mechanisms play a role in shaping plastic neuronal functions (ii)The project VIRGINS explores th",{"id":1077,"funder":7,"programme":8,"title":1078,"piName":10,"institution":1062,"country":135,"year":13,"amount":21,"abstract":1079},"cordis-european-research-council-award-101124230","HUNTING GHOST NEURONS IN THE NEUROENDOCRINE HYPOTHALAMUS","The hypothalamus contains heterogeneous neurons that dictate behaviours and physiological functions through cross-talk mechanisms with peripheral hormones. Neuronal diversity is the key to enabling hypothalamic functions and, according to the neuroscience dogma, is mainly preset during embryonic life. But what if this model is incorrect? Can neuronal heterogeneity be plastically modulated throughout adult life as well? Here, based on my published work and solid preliminary results, I propose tha",{"id":1081,"funder":7,"programme":8,"title":1082,"piName":10,"institution":1083,"country":20,"year":13,"amount":1084,"abstract":1085},"cordis-european-research-council-award-101125325","Asymptotic Speedups for Free through Automatic Incremental Computing","KARLSRUHER INSTITUT FUER TECHNOLOGIE","€1,999,720","The energy consumption of data centers and ICT devices grows at an alarming rate and will be responsible for up to 20% of the global energy consumption by 2030. To sustain the ongoing digital transformation, we must find ways to run software dramatically more efficiently. A promising direction is incremental computing. Incremental computations react to input changes rather than recomputing their result from scratch, which is known to deliver asymptotic speedups in theory and order-of-magnitude s",{"id":1087,"funder":7,"programme":8,"title":1088,"piName":10,"institution":1089,"country":95,"year":13,"amount":21,"abstract":1090},"cordis-european-research-council-award-101087109","Politics of the Periphery’ in Urban Latin America: Reconceptualising Politics from the Margins","WAGENINGEN UNIVERSITY","Existing theory on how residents of urban peripheries engage with the state is largely state-centric. Political anthropology and urban studies have generally conceptualised periphery-state engagements as non-standard citizenship, informal politics, or protest. Such conceptualisations risk contributing to inequality, as they understand the politics of marginalised city residents as less than or only as anti formal state policies and citizenship regimes.POPULAR will counter this disparity by devel",{"id":1092,"funder":7,"programme":8,"title":1093,"piName":10,"institution":1094,"country":12,"year":13,"amount":21,"abstract":1095},"cordis-european-research-council-award-101126117","Forecasting Global Change Impacts On Ecosystems Using a Unified Plant Functional Spectrum","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","Functional traits of organisms determine their responses to the environment, disturbances, biotic interactions, but also their effects on ecosystem processes. Therefore trait-based approaches can potentially advance our understanding of complex ecological questions. However, straightforward approaches for accurate predictions of community composition and ecosystem functioning from traits are not yet available. Studies have considered different traits, which hampers synthesis, and analytical tool",{"id":1097,"funder":7,"programme":8,"title":1098,"piName":10,"institution":1094,"country":12,"year":13,"amount":1099,"abstract":1100},"cordis-european-research-council-award-101124883","Exploring the Molecular Imprint of Microbe-Induced Plant Resistance in Plant-Associated Communities","€2,543,230","Plant-beneficial microbes can modulate the plant immune system enhancing plant resistance to insect pests. This phenomenon, known as Microbe-Induced plant Resistance (MIR) has emerged as a sustainable pest control strategy. Strikingly, my latest results indicate that MIR-immune responses elicited in plants cascade upwards leaving a molecular imprint in surviving insect herbivores (a MIR-imprint). This suggests that MIR-triggered responses in plants could ‘travel’ beyond the plant and be incorpor",{"id":1102,"funder":7,"programme":8,"title":1103,"piName":10,"institution":1094,"country":12,"year":13,"amount":1104,"abstract":1105},"cordis-european-research-council-award-101125858","the Onset of Prebiotic chEmistry iN Space","€1,999,614","The question of the origin of life has intrigued human beings for centuries. Life appeared on Earth about 3.8 billion years ago, but we ignore the process that made it possible. Recent theories propose that primitive Earth was a huge chemical reactor where a high diversity of precursor components progressively turned into primordial metabolic, self-replicating, and membrane-bounded systems. The origin of these components is debated. They could be formed endogenously or exogenously. It is remarka",{"id":1107,"funder":7,"programme":8,"title":1108,"piName":10,"institution":1094,"country":12,"year":13,"amount":1109,"abstract":1110},"cordis-european-research-council-award-101125580","Legonucleotides for detection","€1,999,144","Sensors have a vital importance on human life, detecting diseases or contaminants that endanger the environment. A widely pursued challenge has been to develop universal biosensors with the flexibility to detect molecules regardless of their size. Antibodies have been used to fulfill this aim, but single-stranded oligonucleotides (aptamers) interact efficiently with targets and have also been proposed as an alternative. 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