[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-consolidator-grant-2026":3,"awarded-stats-erc-consolidator-grant":1153},{"awarded":4,"total":1152},[5,16,22,29,35,40,47,51,56,63,68,75,82,88,95,100,106,112,118,123,128,134,140,145,151,157,162,168,174,180,187,194,200,205,211,213,219,224,230,237,243,248,253,260,265,271,276,278,284,290,296,302,309,316,321,327,333,339,345,351,357,363,369,376,382,387,392,397,402,408,414,420,427,433,439,446,452,458,464,470,476,482,488,494,499,506,512,517,524,530,536,540,545,551,557,563,569,575,581,587,593,599,606,612,618,624,630,635,640,645,650,656,662,668,675,681,687,693,699,705,710,715,721,727,732,737,743,749,754,760,765,771,777,784,790,796,801,806,812,817,822,828,834,839,845,851,857,862,866,872,877,883,889,894,899,905,910,916,922,928,933,940,946,951,956,961,967,973,979,984,989,995,1001,1007,1013,1018,1023,1029,1034,1039,1045,1050,1055,1061,1066,1071,1076,1081,1086,1091,1097,1104,1109,1115,1120,1124,1130,1136,1142,1147],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-european-research-council-award-erc-2024-cog-101170920","European Research Council","ERC Consolidator Grant","Food additive mixtures and hypertension and cardiovascular diseases incidence in the NutriNet-Santé prospective cohort","M Payen de la Garanderie","Conservatoire National des Arts et Métiers","FR",2026,null,"Abstract Background Emerging experimental and epidemiological studies suggest that certain combinations of food additives may exert harmful effects that go beyond those observed for individual substances. This study aimed to investigate the associations between chronic exposure to food additive mixtures and the incidence of hypertension and cardiovascular disease (CVD), including cerebrovascular accident (CVA) and coronary heart disease (CHD), in the NutriNet-Santé cohort (2009–2024). Methods A ",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":21,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-cog-groundoc-101171170","From proof to practice: theorizing grassroots documentation initiatives as justice practices in transitional contexts","Tine Destrooper","Ghent University","BE",{"id":23,"funder":7,"programme":8,"title":24,"piName":25,"institution":26,"country":27,"year":13,"amount":14,"abstract":28},"openalex-european-research-council-award-erc-consolidator-grant-101124230-ghostbuster","POMC AMPKα1 deletion drives male-specific BAT thermogenesis and obesity resistance","Ismael González‐García","Universidade de Santiago de Compostela","ES","Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) play a critical role in energy homeostasis. 5'-adenosine monophosphate-activated protein kinase (AMPK) is a serine\u002Fthreonine kinase, which acts as the main energy sensor in the cell. The heterotrimeric AMPK results from the combination of a catalytic α subunit (α1, α2) with two regulatory subunits, β (β1, β2) and γ (γ1, γ2 and γ3). Hypothalamic AMPK plays a key role in the control of energy balance, but current e",{"id":30,"funder":7,"programme":8,"title":31,"piName":32,"institution":33,"country":34,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-cog-865931","Prosocial by default: Defaults boost giving even under distraction and widespread non-responsiveness","Linh Vu","Stanford Medicine","US",{"id":36,"funder":7,"programme":8,"title":37,"piName":38,"institution":39,"country":34,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-cog-819775","Circulating palmitoleic acid is associated with cerebral glucose metabolism in healthy middle-aged individuals: results from the Progression of Early Subclinical Atherosclerosis prospective cohort study","Valentin Fuster","Icahn School of Medicine at Mount Sinai",{"id":41,"funder":7,"programme":8,"title":42,"piName":43,"institution":44,"country":45,"year":13,"amount":14,"abstract":46},"openalex-european-research-council-award-erc-cog-101001889","Coastal strip of the Levantine Corridor for the Calabrian (late Early Pleistocene) hominin migration","N. Ogretmen","Aarhus University","DK","As a geographical bridge across continents, the Levantine Corridor has played an important role in the migration and dispersal of hominins throughout the Pleistocene. Archaeological sites along and around this corridor provide evidence of these movements dating back to the Early Pleistocene, in the form of artefacts and, to a lesser extent, fossils, which attest to the presence of hominins in the region. Interestingly, younger sites (i.e., Calabrian) are located along the coastal strip of the Le",{"id":48,"funder":7,"programme":8,"title":49,"piName":50,"institution":14,"country":14,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-consolidator-grant-meta-lego-no-101001759","Static size-effects meet the dynamic scattering properties of finite-sized mechanical metamaterials: A relaxed micromorphic study with parameter identification via two-stage static–dynamic optimization","Angela Madeo",{"id":52,"funder":7,"programme":8,"title":53,"piName":54,"institution":55,"country":12,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-energised-erc-2021-cog-101043802","Gut microbiome metabolites meet immunometabolism in inflammatory bowel disease","Harry Sokol","Inserm",{"id":57,"funder":7,"programme":8,"title":58,"piName":59,"institution":60,"country":61,"year":13,"amount":14,"abstract":62},"openalex-european-research-council-award-erc-cog-no-101170012","High-Risk Rhabdomyosarcomas Feature a Convergent Cell State","Sam Behjati","University of Cambridge","GB","Abstract Somatic mutations often predict survival in childhood cancers, as exemplified in rhabdomyosarcoma (RMS), in which FOXO1 gene fusion status is a key prognostic feature. In this study, we examined single-cell transcriptomes and discovered that cancer cells of lethal disease converge on a common cell state with a shared transcriptional landscape, irrespective of fusion status. Nuclear transcriptomics, chromatin accessibility, spatial transcriptomics, perturbation studies, and previously pu",{"id":64,"funder":7,"programme":8,"title":65,"piName":66,"institution":14,"country":14,"year":13,"amount":14,"abstract":67},"openalex-european-research-council-award-erc-2021-cog-nonpharm-101045225","A developmental map of pathogen-avoidance behaviors","Joshua M. Tybur","Despite the significant costs of early-life infections, young children show little behavioral avoidance of pathogens. This phenomenon raises still-unanswered questions about when anti-pathogen psychology develops. The present cross-sectional study examined parent-reported observations of 39 behaviors from infancy through middle childhood, based on reports from 3050 parents from the UK and US. Across fine-grained monthly age intervals (0–120 months), distinct developmental trajectories were ident",{"id":69,"funder":7,"programme":8,"title":70,"piName":71,"institution":72,"country":73,"year":13,"amount":14,"abstract":74},"openalex-european-research-council-award-erc-cog-101125516","Genome-wide association study of creatinine clearance identifies new loci for kidney function","Martin H. de Borst","University Medical Center Groningen","NL","Introduction Genome-wide association studies (GWAS) for kidney function have mainly focused on creatinine-based glomerular filtration rate (eGFRcrea), which is affected by variation in muscle mass. Moreover, the genetic basis of the sexual dimorphism of chronic kidney disease is underexplored. Methods We performed a GWAS meta-analysis for creatinine clearance (CrCl), a muscle mass–independent measure of kidney function, in 58,976 individuals of European ancestry from the Lifelines Cohort Study, ",{"id":76,"funder":7,"programme":8,"title":77,"piName":78,"institution":79,"country":80,"year":13,"amount":14,"abstract":81},"openalex-european-research-council-award-erc-cog2020-101002280","Bridging the gap between organelles: Membrane contact sites as regulator of endocytic dynamics","Sara Sigismund","European Institute of Oncology","IT","Endocytosis controls the internalization of molecules, receptors and membrane components, thereby regulating nutrient uptake, signaling and membrane composition. Increasing evidence shows that trafficking of endocytic cargo is coordinated by membrane contact sites (MCSs). Rather than passive bridges, MCSs act as dynamic platforms that organize communication between organelles, integrating metabolic and biochemical signals with spatial precision. Their ability to locally remodel membranes and gen",{"id":83,"funder":7,"programme":8,"title":84,"piName":85,"institution":86,"country":87,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-cog-2020-1-010-003-293","Modern and traditional age constraints for the palaeovegetation trends of the Early Triassic climate events at high southern latitudes","Chris Mays","Natural History Museum Vienna","AT",{"id":89,"funder":7,"programme":8,"title":90,"piName":91,"institution":92,"country":93,"year":13,"amount":14,"abstract":94},"openalex-european-research-council-award-erc-cog-2017","Ultrafast charge transfer dynamics at the MoS 2 \u002F Au interface observed via optical spectroscopy under ambient conditions","Yujin Tong","University of Duisburg-Essen","DE","Integrating atomically thin transition metal dichalcogenides (TMDCs) with metallic surfaces is an effective strategy to leverage their exceptional properties in advanced devices and catalysts, as it promotes efficient charge carrier injection and extraction from TMDC monolayers. Light-matter interactions in TMDC monolayers predominantly occur at the K point, making the charge carrier dynamics at this point essential for optimizing charge transfer efficiency. However, direct probing of the dynami",{"id":96,"funder":7,"programme":8,"title":97,"piName":98,"institution":14,"country":14,"year":13,"amount":14,"abstract":99},"openalex-european-research-council-award-erc-2022-cog-brainscape-101-086-188","The blind spot in research on nature's benefits: Restorative versus instorative effects and potential biases","Simone Kühn","Environmental psychology has extensively documented the restorative effects of nature: the recovery of cognitive resources and emotional well-being following stress or fatigue. Yet, the field may have overlooked instorative effects, where nature enhances functioning from a neutral baseline without prior depletion. We reviewed 54 studies (61 experiments) investigating nature versus urban exposure effects on cognition, affect, and perceived restoration. Studies were categorized as explicit stresso",{"id":101,"funder":7,"programme":8,"title":102,"piName":103,"institution":104,"country":93,"year":13,"amount":14,"abstract":105},"openalex-european-research-council-award-erc-2015-cog","COMPOSITUM 2 \u002F WHEAT FRIZZY PANICLE dosage dependently regulates inflorescence and root architecture in Triticeae cereals","Jochen Kumlehn","Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK)","The distinctive spike-shaped inflorescence architecture in temperate cereals is governed by a complex interplay of genetic factors, including the orthologous WHEAT FRIZZY PANICLE (WFZP) and barley COMPOSITUM 2 (COM2), whose products belong to the APETALA 2\u002F ETHYLENE RESPONSE FACTOR (AP2\u002FERF) family of transcription factors. However, the precise regulatory mechanism driving their function as well as the influence of allele dosage on spike formation and fertility remain to be elucidated specifical",{"id":107,"funder":7,"programme":8,"title":108,"piName":109,"institution":110,"country":93,"year":13,"amount":14,"abstract":111},"openalex-european-research-council-award-erc-2018-cog-816564-actioncontrathreat","A systematic review of human avoidance learning: Cognition, computation, and methods","Federico Mancinelli","University of Bonn","Avoidance behaviour is fundamental for survival but can become maladaptive in clinical conditions. A large body of literature has accumulated on the dynamics of human avoidance learning. However, current theories and overviews do not provide an exhaustive account of this evidence. In this systematic review, we identify N = 116 studies on human avoidance learning. We analyse these studies with the goal of distilling robust empirical phenomena as a basis for theory-building, and examine their diag",{"id":113,"funder":7,"programme":8,"title":114,"piName":115,"institution":116,"country":34,"year":13,"amount":14,"abstract":117},"openalex-european-research-council-award-erc-2025-cog-101232252","Neurodegeneration as a dysregulation of neuroimmune crosstalk","F. Chris Bennett","Children's Hospital of Philadelphia","Neurodegeneration is increasingly recognized not only as a disorder of neurons but also as a breakdown of dialogue between the nervous and immune systems. Recent discoveries reveal that immune cells and inflammatory signals are deeply interwoven with brain function across the lifespan. Far from passive responders, immune cells act as sentinels and shapers of neuronal resilience, vulnerability, and repair. Together, robust data support a model in which neurodegeneration emerges from complex inter",{"id":119,"funder":7,"programme":8,"title":120,"piName":121,"institution":122,"country":34,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-cog-microtouch-101045015","Biodiversity and biogeography of the multi-kingdom cancer microbiome","Anders B. Dohlman","Dana-Farber Cancer Institute",{"id":124,"funder":7,"programme":8,"title":125,"piName":126,"institution":60,"country":61,"year":13,"amount":14,"abstract":127},"openalex-european-research-council-award-consolidator-grant-mighty-866005","Suppressing gliding in Ni-rich single-crystal cathodes by defect engineering","Clare P. Grey","Defect engineering has been used for centuries to enhance the mechanical strength of metals and alloys, but its application to cathodes remains largely unexplored. Conventional cathode synthesis aims for defect-free crystals to maximize capacity, but such structures degrade easily through interlayer gliding and microcracking, both of which are reported for single-crystal LiNi 0.8 Mn 0.1 Co 0.1 O 2 (SC-NMC811). Dopant substitution or surface coating has been explored to address these issues but i",{"id":129,"funder":7,"programme":8,"title":130,"piName":131,"institution":132,"country":61,"year":13,"amount":14,"abstract":133},"openalex-european-research-council-award-erc-2019-cog-866328","Increased grain weight conferred by GW2 mutations in wheat does not translate into yield gains in multi-year field trials of near-isogenic lines","James Simmonds","John Innes Centre","Multiple studies have identified genes affecting grain morphology, yet their capacity to deliver yield gains under field conditions remains unclear. We performed a multiyear, multilocation factorial evaluation of GRAIN WIDTH2 (TaGW2) mutants in hexaploid wheat using BC4 near-isogenic lines, sowing-density treatments and semi-dwarfing RHT1 backgrounds. Loss-of-function mutations in TaGW2 increased grain size and thousand grain weight (TGW) additively; with the aaBBDD single mutant showing the mos",{"id":135,"funder":7,"programme":8,"title":136,"piName":137,"institution":138,"country":12,"year":13,"amount":14,"abstract":139},"openalex-european-research-council-award-erc-2015-cog-ga-648974","Preserving Proton Resolution Under Cryogenic Dynamic Nuclear Polarization for Biomolecular Solid‐State NMR","Antoine Loquet","Centre National de la Recherche Scientifique","ABSTRACT The combination of proton detection with cryogenic dynamic nuclear polarization (DNP) promises to unite the intrinsic sensitivity and resolution of 1 H‐detected magic‐angle spinning (MAS) NMR with the large signal enhancements afforded by hyperpolarization, but has long been considered impractical because of cryogenic line broadening and the limited spinning frequencies available under DNP conditions. Here, we demonstrate that high‐resolution proton‐detected spectra of proteins can inde",{"id":141,"funder":7,"programme":8,"title":142,"piName":143,"institution":144,"country":27,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2022-cog-101086483","Bile salts govern protein bioaccessibility and nanostructural assembly during digestion of Nori seaweed","Marta Martínez‐Sanz","Instituto de Investigación en Ciencias de la Alimentación",{"id":146,"funder":7,"programme":8,"title":147,"piName":148,"institution":149,"country":45,"year":13,"amount":14,"abstract":150},"openalex-european-research-council-award-cog-101125803","PAK4: A vanguard of epithelial vertex remodeling","Jakub Sedzinski","Novo Nordisk Foundation","How epithelial tissues remodel while preserving their barrier remains a fundamental question in epithelial biology. In this issue, Adhikary et al. (https:\u002F\u002Fdoi.org\u002F10.1083\u002Fjcb.202510024) identify PAK4 as a dynamic regulator of vertex remodeling that fine-tunes actomyosin contractility to maintain tissue integrity.",{"id":152,"funder":7,"programme":8,"title":153,"piName":154,"institution":155,"country":93,"year":13,"amount":14,"abstract":156},"openalex-european-research-council-award-erc-cog-101088582-interact","Emotional processing biases in the longitudinal course of major depressive disorder","Katharina Hierl","Technische Universität Dresden","Negative biases in emotional processing are central to cognitive models of Major Depressive Disorder (MDD), yet it remains unclear whether negatively biased valence attribution covaries with depressive symptoms or represents a more stable vulnerability. In this longitudinal study, we examined emotional valence ratings during a subliminal affective priming task in n = 232 MDD patients and n = 496 healthy controls (HC's) across multiple follow-up assessments, yielding 1395 observations. Multilevel",{"id":158,"funder":7,"programme":8,"title":159,"piName":160,"institution":161,"country":93,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-cog-2021-finisterra-101045506","Tectonic collapse and the geological masking of Paleolithic human occupations at Gruta da Companheira (southern Portugal)","Alvise Barbieri","Max Planck Institute for the Science of Human History",{"id":163,"funder":7,"programme":8,"title":164,"piName":165,"institution":166,"country":61,"year":13,"amount":14,"abstract":167},"openalex-european-research-council-award-2023-cog-101124151","Design of experiments-driven optimization of dual ultra-high-performance liquid chromatography high resolution mass spectrometry for integrated fecal metabolomics and lipidomics","Lynn Vanhaecke","Queen's University Belfast","Recently, feces has gained increased attention in metabolomics and lipidomics research due to its ability to reflect complex diet-host-microbiome interactions. Traditionally, these analyses rely on separate workflows, resulting in longer analysis times and increased instrument load. To address these limitations, we present a dual ultra-high-performance liquid chromatography coupled to high-resolution mass spectrometry (dual UHPLC-HRMS) approach. As a first step, two previously validated single U",{"id":169,"funder":7,"programme":8,"title":170,"piName":171,"institution":172,"country":73,"year":13,"amount":14,"abstract":173},"openalex-european-research-council-award-erc-2017-cog-773023","Bidirectional associations between parental need support, conflict with parents, and adolescents’ autonomy: A daily diary study","Susan Branje","Utrecht University","Autonomy is a core developmental task of adolescence, shaped by daily parent-adolescent interactions involving need support and conflict. Guided by Self-Determination Theory, this study examined the bidirectional day-to-day associations between adolescents' perceived parental need support, conflict with parents, and autonomy. Using a daily diary design, this study employed a Dynamic Structural Equation Modeling on a sample of 286 Dutch adolescents (Mage = 11.60, SD = 0.47 at Wave 1), who were fo",{"id":175,"funder":7,"programme":8,"title":176,"piName":177,"institution":178,"country":27,"year":13,"amount":14,"abstract":179},"openalex-european-research-council-award-erc-2023-cog-101124883-mimir","Herbivory-triggered assemblage of sunflower rhizosphere microbiome enhances herbivore tolerance through plant–soil feedback","P. M. Rodríguez-Blanco","Universidad de Salamanca","Abstract Rhizosphere microbial communities are key drivers of plant immunity and stress responses, and plants recruit beneficial microorganisms under stress. Herbivorous insects pose a major agricultural challenge, yet how leaf herbivory influences root-associated microbiomes and whether these changes generate plant–soil feedbacks that alter plant defense phenotypes remain poorly understood. With a two-phase greenhouse bioassay, we investigated how leaf herbivory with Spodoptera exigua affects s",{"id":181,"funder":7,"programme":8,"title":182,"piName":183,"institution":184,"country":185,"year":13,"amount":14,"abstract":186},"openalex-european-research-council-award-erc-cog2019-865437","Advances in magnetic-based thermometry and temperature mapping","Nuno J. O. Silva","University of Aveiro","PT","Temperature monitoring plays a critical role in a variety of therapeutic applications, including thermal therapies. Magnetic-based thermometry has emerged as a versatile and promising approach for localized, wireless temperature monitoring and mapping. This review provides an overview of the latest advances in magnetic temperature sensing techniques, with a focus on Magnetic Resonance Imaging (MRI) and Magnetic Particle Imaging (MPI). Established MRI thermometry techniques based on the variation",{"id":188,"funder":7,"programme":8,"title":189,"piName":190,"institution":191,"country":192,"year":13,"amount":14,"abstract":193},"openalex-european-research-council-award-erc-2022-cog-faim-101088193","An introduction to String Newton-Cartan holography and integrability","Andrea Fontanella","Trinity College Dublin","IE","Abstract String Newton-Cartan holography is a new example of gauge\u002Fgravity duality relating non-relativistic string theory and gauge theories. We review how to construct a family of string and p-brane Newton-Cartan holographic dualities by consistently taking the non-relativistic limit of the AdS\u002FCFT correspondence. We also review classical string solutions, quantisation, string coset action and integrability of the non-relativistic string theory appearing in the String Newton-Cartan limit of th",{"id":195,"funder":7,"programme":8,"title":196,"piName":197,"institution":198,"country":73,"year":13,"amount":14,"abstract":199},"openalex-european-research-council-award-erc-cog864180","Optimizing Plasmodium vivax gametocyte enrichment to enhance transmission to Anopheles mosquitoes","Wouter Graumans","Radboud University Nijmegen","\u003Cns5:p> Background \u003Cns5:italic>Plasmodium vivax\u003C\u002Fns5:italic> is the second leading cause of malaria worldwide. The lack of continuous \u003Cns5:italic>in vitro\u003C\u002Fns5:italic> culture of \u003Cns5:italic>P. vivax\u003C\u002Fns5:italic> hampers research efforts, including research on transmission to mosquitoes and sporozoite biology \u003Cns5:italic>.\u003C\u002Fns5:italic> Here, we present methodological improvements to achieve high mosquito infection rates. Methods We compared two gametocyte enrichment methods: magnetic cell sortin",{"id":201,"funder":7,"programme":8,"title":202,"piName":203,"institution":55,"country":12,"year":13,"amount":14,"abstract":204},"openalex-european-research-council-award-erc-2017-cog-770244","FUS controls muscle differentiation through phase separation-mediated recruitment of the transcription factors MEF2 and ETV5","Chantal Sellier","FUS is an RNA-binding protein mutated in amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by progressive muscle weakness. We show in this work that a heterozygous knock-in mutation in the mouse Fus gene leads to cell-autonomous ultrastructural defects in skeletal muscle, with disruption of sarcomeres and mitochondria. Studies in mouse and Drosophila models demonstrate an evolutionarily conserved cell-autonomous function of FUS in muscle development. Mechanistically,",{"id":206,"funder":7,"programme":8,"title":207,"piName":208,"institution":209,"country":61,"year":13,"amount":14,"abstract":210},"openalex-european-research-council-award-erc-2021-cog-101002587","Chronic health conditions and health-related economic inactivity in midlife: Evidence from the 1958 and 1970 British birth cohorts","Laura Gimeno","London International Development Centre","ABSTRACT Background Health-related economic inactivity is a growing concern in the United Kingdom but little is known about how the relationship between health and work participation has changed across cohorts. Methods We used data from two British birth cohorts born in 1958 (National Child Development Study, n = 9,761) and 1970 (British Cohort Study, n = 7,336). We examined how self-reported chronic health conditions at age 42 (longstanding illness, obesity, diabetes, high blood pressure, back ",{"id":212,"funder":7,"programme":8,"title":97,"piName":98,"institution":14,"country":14,"year":13,"amount":14,"abstract":99},"openalex-european-research-council-award-erc-2022-cog-brainscape-101086188",{"id":214,"funder":7,"programme":8,"title":215,"piName":216,"institution":217,"country":80,"year":13,"amount":14,"abstract":218},"openalex-european-research-council-award-consolidator-grant-101089107-green-tipping-","An empirical socio-economic indicator of country-level food security","Alessandro Tavoni","University of Bologna","Abstract Economic access is a 10 central dimension of food security, yet cross-country empirical work has limited panel-compatible measures that link the purchasing power of low-income populations to food expenditure. We introduce the Socio-Economic Index of Food Security (SEF), defined as the ratio between the per capita income of the bottom 20 percent of the income distribution and average per capita food expenditure. Using data from 110 countries, we examine the ability of SEF to explain cros",{"id":220,"funder":7,"programme":8,"title":221,"piName":222,"institution":39,"country":34,"year":13,"amount":14,"abstract":223},"openalex-european-research-council-award-cog-grant-artfibro-101088596","Dendritic cells control tertiary lymphoid structure development and maintenance in cancer","Miriam Mérad","Tertiary lymphoid structures (TLSs) are associated with immunotherapy response, yet the mechanisms controlling their formation and maintenance remain unclear. Using spatial transcriptomics and multiplex imaging across human tumors, we found that CCR7 + mature dendritic cells (DCs) accumulate in TLSs. In a mouse non–small cell lung cancer model that forms mature TLSs, we show that early TLS development requires interferon-γ (IFN-γ)–driven type 1 conventional dendritic cell (cDC1) maturation, migr",{"id":225,"funder":7,"programme":8,"title":226,"piName":227,"institution":228,"country":93,"year":13,"amount":14,"abstract":229},"openalex-european-research-council-award-erc-cog-2024-101171358","Polyelectrolyte adsorption at the solid–liquid interface favors receding contact line instability","Hans‐Jürgen Butt","Max Planck Institute for Polymer Research","Controlling the motion of non-Newtonian drops on surfaces is crucial for applications ranging from inkjet printing to biomedical devices and food processing. While the macroscopic behavior of viscoelastic drops sliding on tilted hydrophobic surfaces has been characterized—showing reduced velocities and elongation compared to Newtonian fluids—the underlying microscopic mechanisms remain poorly understood. To address this gap, we developed a high-speed, high-resolution reflection microscope that e",{"id":231,"funder":232,"programme":8,"title":233,"piName":234,"institution":235,"country":93,"year":13,"amount":14,"abstract":236},"openalex-horizon-europe-european-research-council-award-cog-101088027","HORIZON EUROPE European Research Council","A 3’UTR-derived small RNA modulates the life cycle of the cholera toxin–encoding filamentous phage, CTXϕ","Kai Papenfort","Friedrich Schiller University Jena","ABSTRACT Bacteriophages (phages) are well known to be one of the major driving forces in bacterial evolution. This also applies to virulent microorganisms, such as the major human pathogen Vibrio cholerae , whose pathogenic potential and epidemic proliferation largely depends on the interaction with environmental phages. Specifically, integration of the CTXϕ phage genome into the first chromosome of V. cholerae also introduced the ctxAB genes, encoding the primary toxin responsible for the sever",{"id":238,"funder":232,"programme":8,"title":239,"piName":240,"institution":241,"country":34,"year":13,"amount":14,"abstract":242},"openalex-horizon-europe-european-research-council-award-consolidator-grant-cocoquest-101043705","Unlocking the potential of high-dimensional quantum communication with scalable photonic entanglement in time and frequency","Chee Wei Wong","University of California, Los Angeles","High-dimensional photonic entanglement holds substantial promise for advancing quantum communication, computation, and metrology. For example, large-alphabet quantum communication protocols are known to benefit from enhanced noise resilience and information capacity via multibit time-bin encoding. Yet, characterizing high-dimensional entangled states is challenging, as full-state tomography becomes prohibitively costly and often requires unrealizable measurements. Here, we demonstrate a scan-fre",{"id":244,"funder":232,"programme":8,"title":245,"piName":246,"institution":138,"country":12,"year":13,"amount":14,"abstract":247},"openalex-horizon-europe-european-research-council-award-725907-erc-2016-cog","Mechanical constraints regulate embryonic stem cell mitosis in the developing brain","Véronique Marthiens","Research on mitosis has predominantly examined cell-autonomous mechanisms, yet its regulation and consequences within the broader physiological context remain largely unexplored. It remains, therefore, unknown whether and how spindle assembly and chromosome segregation are influenced by tissue properties. We have investigated this question in the mammalian embryonic brain, using high-resolution microscopy combined with pharmacological perturbations and minimal cell systems to break down the cont",{"id":249,"funder":7,"programme":8,"title":250,"piName":251,"institution":60,"country":61,"year":13,"amount":14,"abstract":252},"openalex-european-research-council-award-erc-2016-cog-725126","Cell cycle checkpoint activity in the malaria parasite \u003Ci>Plasmodium falciparum\u003C\u002Fi>","Catherine J. Merrick","ABSTRACT Plasmodium spp. have different modes of cell division from most eukaryotes. Little is known about how these are controlled, and cell cycle checkpoints are particularly poorly characterized. However, parasites can arrest their cell cycle when treated with the frontline antimalarial drug artemisinin, and artemisinin-resistant parasites can modulate their cell cycle progression, so it is important to understand these aspects of Plasmodium biology. Here, we show that P. falciparum displays ",{"id":254,"funder":7,"programme":8,"title":255,"piName":256,"institution":257,"country":258,"year":13,"amount":14,"abstract":259},"openalex-european-research-council-award-cog-770924","Inverse problems for semilinear elliptic PDE with a general nonlinearity a(x,u)","Janne Nurminen","Lappeenranta-Lahti University of Technology","FI","Abstract This article studies the inverse problem of recovering a nonlinearity in an elliptic equation from boundary measurements of solutions. Previous results based on first‐order linearization achieve this under a sign condition on , and results based on higher order linearization recover the Taylor series of with respect to . We improve these results and show that a general nonlinearity, and not just its Taylor series, is uniquely determined up to gauge near a fixed solution. Our method is b",{"id":261,"funder":7,"programme":8,"title":262,"piName":263,"institution":14,"country":14,"year":13,"amount":14,"abstract":264},"openalex-european-research-council-award-erc-cog-magnify-101126182","Wildly oscillating stars. Unexplained dense ridge-like frequency agglomerations in A- and F-type pulsators","P. Mani","We investigate the origin of the dense, ridge-like frequency clusters observed in a subset of A- and F-type pulsating stars, which we refer to as `wildly oscillating' stars (WOSs). These agglomerated frequency regions occupy a confined part of the frequency spectrum, typically below the fundamental radial mode, and they cannot be explained on the basis of classical pulsation theory. We analysed high-precision space photometry from and TESS, constructed échelle diagrams, and performed systematic ",{"id":266,"funder":7,"programme":8,"title":267,"piName":268,"institution":269,"country":192,"year":13,"amount":14,"abstract":270},"openalex-european-research-council-award-erc-supramol-cog-2014-647719","Ce(III)-MOFs with 1D chain architectures and their derivatives as earth-abundant electrocatalysts for the acidic oxygen evolution reaction","Wolfgang Schmitt","University College Dublin","Cerium(III)-based metal-organic frameworks (Ce-MOFs) with one-dimensional chain secondary building units were synthesised and evaluated as oxygen evolution reaction (OER) electrocatalysts in acid. The MOFs act as pre-catalysts, transforming in-situ into active cerium oxide species. The best pristine MOF material that employs 1,3,5-triazine-2,4,6-triyl)tris(thiophene-2-carboxylate linkers (H3TTT), shows higher intrinsic activity and stability than commercial CeO2. The results highlight the role o",{"id":272,"funder":7,"programme":8,"title":273,"piName":274,"institution":275,"country":34,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-cog-770992","Genome‐wide association study in 21,271 individuals identifies 9 novel loci associated with circulating CD34 \u003Csup>+\u003C\u002Fsup> hematopoietic stem and progenitor cell levels","Björn Nilsson","Broad Institute",{"id":277,"funder":7,"programme":8,"title":239,"piName":240,"institution":241,"country":34,"year":13,"amount":14,"abstract":242},"openalex-european-research-council-award-consolidator-grant-cocoquest-101043705",{"id":279,"funder":7,"programme":8,"title":280,"piName":281,"institution":282,"country":34,"year":13,"amount":14,"abstract":283},"openalex-european-research-council-award-erc-cog-2018-segop-no-101115949-","Developmental Timing of Educational Opportunities for Children in Low-Income Households","Eric Dearing","Boston College","Extending findings from a 26-year longitudinal study of educational opportunity, we examine whether opportunities are related to the educational attainment and earnings of children from lower-income households ( n = 226) as a function of when in a child’s development they occur. We compare the predictive power of opportunities accrued within three key developmental stages—early childhood, middle childhood, or adolescence—with the combined power of opportunities accrued across these stages. Our f",{"id":285,"funder":7,"programme":8,"title":286,"piName":287,"institution":288,"country":27,"year":13,"amount":14,"abstract":289},"openalex-european-research-council-award-erc-cog-2019-865554","Scaffold Hopping of Isoxazole Enabled by an Oxidative Rh-Catalyzed Single-Carbon Insertion","Marcos G. Suero","Institució Catalana de Recerca i Estudis Avançats","High Resolution Image Download MS PowerPoint Slide Scaffold hopping is a key strategy in medicinal chemistry for lead optimization, but its application is often constrained by the need to synthesize each analogue from scratch. Single-atom skeletal editing offers an attractive alternative, yet methods for isoxazole scaffolds−especially in complex, medicinally relevant contexts−remain limited. Here, we present a scaffold hopping approach for isoxazoles based on an oxidative Rh-catalyzed single-car",{"id":291,"funder":7,"programme":8,"title":292,"piName":293,"institution":294,"country":87,"year":13,"amount":14,"abstract":295},"openalex-european-research-council-award-cog-866166","Cellular assembly and functional resilience of the mammalian RNA exosome","Stefan L. Ameres","Institute of Molecular Biotechnology","Most eukaryotic proteins assemble into multisubunit complexes that coordinate essential cellular functions, yet the principles governing their assembly and proteostatic control remain largely undefined. Here, we systematically dissect the cellular assembly and functional organization of the RNA exosome, an essential ribonucleolytic complex, using an inducible dual-guide CRISPR\u002FCas9 system in mouse embryonic stem cells. We reveal a sequential assembly pathway where Exosc2, Exosc4, and Exosc7 init",{"id":297,"funder":7,"programme":8,"title":298,"piName":299,"institution":300,"country":27,"year":13,"amount":14,"abstract":301},"openalex-european-research-council-award-erc-2021-cog-101044248","OMA1 protects from liver injury and tumorigenesis during aging by controlling hepatic immunogenicity","José Antonio Enrı́quez","Spanish National Centre for Cardiovascular Research","Abstract Hepatic inflammation and immunosurveillance play major roles in the progression of liver cancer. A common trigger for hepatic inflammation is oxidative stress, which stems from mitochondrial dysfunction. Here, we demonstrate that deletion of the mitochondrial stress integrator OMA1 increases hepatic primary tumor incidence and impairs survival in mice. Persistent activation of the KEAP1-Nrf2 oxidative stress pathway in the absence of OMA1 promotes early liver injury, which progresses in",{"id":303,"funder":7,"programme":8,"title":304,"piName":305,"institution":306,"country":307,"year":13,"amount":14,"abstract":308},"openalex-european-research-council-award-erc-2013-cog-616986","Statins promote muscle metabolic danger and NLRP3-mediated myopathy via lower protein-prenylation and YAP","Nazli Robin","McMaster University","CA","Statin intolerance and side effects such as low-level myopathy limit statin use and the dose for optimal cholesterol lowering. We found that priming the NLRP3 inflammasome with bacterial components like lipopolysaccharide lowered the dose of statins that caused side effects in muscle cells. We then built models of low-level statin myopathy and found that muscle cell–autonomous statin-induced myopathy occurs through the NLRP3 inflammasome in vitro and in mice. Statin-induced muscle cell death and",{"id":310,"funder":7,"programme":8,"title":311,"piName":312,"institution":313,"country":314,"year":13,"amount":14,"abstract":315},"openalex-european-research-council-award-erc-2023-cog-101124329","Strong exciton coupling: a practical toolbox for computing interaction energies, wavefunctions, and optical spectra","Karl Börjesson","University of Gothenburg","SE","The perceived colour and photophysical properties of organic dyes depend not only on their chemical structure, but also how they pack together. When two dyes approach one another, the transition dipole moments associated with their molecular states begin to interact. If this interaction is sufficiently strong, it can lead to hybridization of the excited states, forming new hybrid states with altered photophysical properties. This phenomenon, formally denoted strong exciton coupling, is commonly ",{"id":317,"funder":7,"programme":8,"title":318,"piName":319,"institution":320,"country":27,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2021-cog-101043428","Synthetic amino acids for programming adaptive response in pyrazolate peptide frameworks","Natalia M. Padial","Universitat de València",{"id":322,"funder":7,"programme":8,"title":323,"piName":324,"institution":325,"country":93,"year":13,"amount":14,"abstract":326},"openalex-european-research-council-award-erc-2023-cog","Adult neurogenesis: New neurons, new opportunities","Gerd Kempermann","German Center for Neurodegenerative Diseases","The 38 currently registered clinical trials with the keyword \"adult neurogenesis\" indicate growing interest in new neurons as a target for intervention. Today, we have strong evidence that adult neurogenesis is involved in hippocampal function and can contribute to brain functions in health and disease. Neurogenesis research can now ask new questions, such as (1) the identity of stem cells and their input integration for initiating neurogenesis, (2) the nature of the neurogenic niche and neuroge",{"id":328,"funder":7,"programme":8,"title":329,"piName":330,"institution":331,"country":185,"year":13,"amount":14,"abstract":332},"openalex-european-research-council-award-h2020-erc-2018-cog-81904","Spatiotemporal coordination of Slit-Robo repulsion and neurturin-Gfrα attraction guides multipolar migration during retinal lamination","Jaakko Lehtimäki","Instituto Gulbenkian de Ciência","Multipolar migration is a conserved neuronal migration mode in the developing brain, enabling emerging neurons to navigate in crowded environments and reach precise laminar positions. Yet, how these cells interpret external cues to guide their migration is not fully understood. We investigate this question using retinal horizontal cells as a model. Combining transcriptomics, targeted CRISPR screening, and live imaging, we reveal the spatiotemporal guidance system underlying horizontal cell lamin",{"id":334,"funder":7,"programme":8,"title":335,"piName":336,"institution":337,"country":93,"year":13,"amount":14,"abstract":338},"openalex-european-research-council-award-erc-cog-772395","Thermal-state-dependent control of body temperature and feeding by two intra-hypothalamic pathways","Jan Siemens","European Molecular Biology Organization","The intricate interplay between energy metabolism and body temperature regulation underscores the necessity of finely tuned mechanisms to maintain thermo-energetic homeostasis. Hot environments are known to suppress food intake and to reduce energy expenditure. However, the interplay between thermoregulatory and caloric-regulatory hypothalamic areas remains largely unexplored. In this study, we unveil two pathways originating from a subpopulation of genetically defined leptin receptor-expressing",{"id":340,"funder":7,"programme":8,"title":341,"piName":342,"institution":343,"country":185,"year":13,"amount":14,"abstract":344},"openalex-european-research-council-award-erc-2016-cog-726061","Correction: Reis et al. Bioinks Enriched with ECM Components Obtained by Supercritical Extraction. Biomolecules 2022, 12, 394","Alexandra P. Marques","University of Minho","In the original publication [...]",{"id":346,"funder":7,"programme":8,"title":347,"piName":348,"institution":349,"country":12,"year":13,"amount":14,"abstract":350},"openalex-european-research-council-award-erc-2017-cog-772178","Two temperature-dependent membrane fluidity regimes in gram-positive bacteria","Rut Carballido‐López","AgroParisTech","ABSTRACT Temperature changes directly affect the mobility of molecules within a biological membrane, increasing or decreasing its fluidity. Plasma membrane fluidity is a fundamental physical property that governs bacterial cell physiology, influencing processes such as protein function, respiration, and antibiotic uptake. It is widely accepted that bacteria actively maintain a constant membrane fluidity in response to temperature fluctuations to preserve membrane function. This process, known as",{"id":352,"funder":7,"programme":8,"title":353,"piName":354,"institution":355,"country":27,"year":13,"amount":14,"abstract":356},"openalex-european-research-council-award-erc-cog-2022-camp-101088842","Anthropic Activity Markers 2.0: A Shift Towards Compositional Data Analysis","Abel Ruiz-Giralt","Universitat Pompeu Fabra","Abstract Anthropic Activity Markers (AAMs) were formalized over 10 years ago as a toolkit to infer human activities from biological and geochemical signatures preserved in sediments. This paper presents AAMs 2.0, a revised analytical framework that integrates compositional data analysis (CoDA) and geostatistics, as the appropriate statistical foundations for this approach. We first outline the theoretical motivation of this framework, demonstrating that treating geochemical concentrations as abs",{"id":358,"funder":7,"programme":8,"title":359,"piName":360,"institution":361,"country":87,"year":13,"amount":14,"abstract":362},"openalex-european-research-council-award-cog-863818","SuperDP: Differential Privacy Refutation via Supermartingales","Krishnendu Chatterjee","Institute of Science and Technology Austria","Differential privacy (DP) has established itself as one of the standards for ensuring privacy of individual data. However, reasoning about DP is a challenging and error-prone task, hence methods for formal verification and refutation of DP properties have received significant interest in recent years. In this work, we present a novel method for automated formal refutation of є-DP. Our method refutes є-DP by searching for a pair of inputs together with a non-negative function over outputs whose e",{"id":364,"funder":7,"programme":8,"title":365,"piName":366,"institution":367,"country":34,"year":13,"amount":14,"abstract":368},"openalex-european-research-council-award-eliminate-ckd-erc-cog-101125516","Benchmarking the urinary transplant metabolome of kidney transplant recipients using healthy organ donors","Naser B.N. Shehab","Brigham and Women's Hospital","Background Kidney transplantation is the only curative treatment for end-stage kidney disease, providing markedly improved outcomes over dialysis. In search of optimized long-term outcomes, recent studies have demonstrated alterations in the metabolic state of kidney transplant recipients (KTRs) may contribute to chronic graft outcomes. Here, we sought to benchmark metabolic perturbations associated with the post-transplant state using a set of extensively characterized kidney transplant donors ",{"id":370,"funder":7,"programme":8,"title":371,"piName":372,"institution":373,"country":374,"year":13,"amount":14,"abstract":375},"openalex-european-research-council-award-cog-101169732","Parsing the functions of immediate-early proteins in the lytic–latent balance of HCMV infection","Noam Stern-Ginossar","Weizmann Institute of Science","IL","Human cytomegalovirus (HCMV) establishes lifelong latency, during which immediate-early (IE) gene expression is strongly repressed. IE1 and IE2 are considered master regulators of the lytic cycle, yet it remains unclear whether their expression levels are sufficient to determine infection outcome, defined here as the balance between lytic and latent infection, and which viral or cellular processes underpin this control. Here, we show that when viral entry is enhanced in monocytes, overexpression",{"id":377,"funder":7,"programme":8,"title":378,"piName":379,"institution":380,"country":34,"year":13,"amount":14,"abstract":381},"openalex-european-research-council-award-cog-darksers-772108","Stabilizing in-transition phases of superlattices through shape control of silver nanocrystals","Sharon C. Glotzer","University of Michigan","In nanoscale assemblies, observations of structures in the transition pathways between high-symmetry lattices are rare because of the inherent instability of the intermediate phases. We report that silver nanocrystals with shapes similar to truncated octahedra (mecons) self-assemble into superlattices that are stable and resemble a previously unobserved phase that bridges face-centered and body-centered cubic structures along the Nishiyama-Wassermann martensitic pathway. These superlattices exhi",{"id":383,"funder":7,"programme":8,"title":384,"piName":385,"institution":14,"country":14,"year":13,"amount":14,"abstract":386},"openalex-european-research-council-award-erc-cog-rambas-project-nr-101044249","The correlation energy of the electron gas in the mean-field regime","Martin Ravn Christiansen","We prove a rigorous lower bound on the correlation energy of interacting fermions in the mean-field regime for a wide class of singular interactions, including the Coulomb potential. Combined with the upper bound obtained in \\cite{ChrHaiNam-23b}, our result establishes an analogue of the Gell-Mann--Brueckner formula $c_{1}ρ\\log\\left(ρ\\right)+c_{2}ρ$ for the correlation energy of the electron gas in the high-density limit. Moreover, our analysis allows us to go beyond mean-field scaling while sti",{"id":388,"funder":7,"programme":8,"title":389,"piName":390,"institution":14,"country":14,"year":13,"amount":14,"abstract":391},"openalex-european-research-council-award-cog-816268","Synthesis and Characterization of Monomeric, Dimeric, and Polymeric Rare-Earth Bis(trimethyl)silylphosphide Complexes","Eric J. L. McInnes","Rare-earth (RE) bis(trimethylsilyl)amide ({N(SiMe3)2}−, N″) chemistry is well-developed, whereas RE bis(trimethylsilyl)phosphide {P(SiMe3)2}− (P″) chemistry is immature. Here, we report a convenient protonolysis route to dimeric RE P″ complexes [RE(P″)2(μ-P″)]2 (1-RE; RE = Y, Gd, Dy, Er) from parent [RE(CH2C6H4-o-NMe2)3] and excess HP″. The reactions of 1-RE with THF gave the monomeric RE P″ complexes [RE(P″)3(THF)2] (2-RE; RE = Y, Gd, Dy, Er), and treatment of 1-RE with 2 eq. of KP″ gave the RE",{"id":393,"funder":7,"programme":8,"title":394,"piName":395,"institution":14,"country":14,"year":13,"amount":14,"abstract":396},"openalex-european-research-council-award-erc-cog-101045437","Robustness of pairwise kinematic Sunyaev--Zel'dovich effect to optical-cluster-selection bias","Y.-H. Hsu","The pairwise kinematic Sunyaev--Zel'dovich,(kSZ) effect measures both the pairwise motion between galaxy groups and clusters and the amount of gas within them, providing a tracer for cosmic growth. To interpret the cosmological information in the kSZ measurements, it is crucial to understand the optical-cluster-selection bias on the kSZ observables. Line-of-sight structures that contribute to both the optical observable (e.g., richness) and the cosmological signal can induce a correlation betwee",{"id":398,"funder":7,"programme":8,"title":399,"piName":400,"institution":14,"country":14,"year":13,"amount":14,"abstract":401},"openalex-european-research-council-award-consolidator-grant-101044123-randomhypgra-","Stability of large cuts in random graphs","Ilay Hoshen","We prove that the family of largest cuts in the binomial random graph exhibits the following stability property: If $1\u002Fn \\ll p = 1-Ω(1)$, then, with high probability, there is a set of $n - o(n)$ vertices that is partitioned in the same manner by all maximum cuts of $G_{n,p}$. Moreover, the analogous statement remains true when one replaces maximum cuts with nearly-maximum cuts. We then demonstrate how one can use this statement as a tool for showing that certain properties of $G_{n,p}$ that hol",{"id":403,"funder":7,"programme":8,"title":404,"piName":405,"institution":406,"country":93,"year":13,"amount":14,"abstract":407},"openalex-european-research-council-award-erc-2019-cog-863934","Cryogenic Infrared Spectroscopy Unmasks Gas‐Phase Charge Migration in Mucin‐Type \u003Ci>O\u003C\u002Fi> ‐Glycans","Marc Safferthal","Fritz Haber Institute of the Max Planck Society","ABSTRACT O ‐glycosylation is an essential post‐translational modification, controlling biological processes like innate immunity, lubrication, and cell communication. Due to the inherent structural complexity of O ‐glycans, assigning exact structures by mass spectrometry is highly challenging. Detailed structural assignment involves laborious processing and data interpretation but often remains incomplete due to the absence of diagnostic fragments. In this work, we introduce cryogenic gas‐phase ",{"id":409,"funder":7,"programme":8,"title":410,"piName":411,"institution":412,"country":73,"year":13,"amount":14,"abstract":413},"openalex-european-research-council-award-erc-cog-772923","Community Turnover and Connectivity at Two Study Sites in the North and Wadden Seas: Dynamics From Hours to Seasons","Pierre Ramond","Royal Netherlands Institute for Sea Research","Microbial communities underpin ecosystem processes and biogeochemical cycles in marine ecosystems, yet their spatial and temporal dynamics at hourly scales remain poorly understood. We surveyed two stations from the North Sea (NS) and Wadden Sea (WS), generating six high-frequency time-series datasets across depths and seasons, complemented by sediment cores. Across seasons, the sites in the NS and the WS harbored distinct microbial communities shaped by contrasts in salinity, temperature, and p",{"id":415,"funder":7,"programme":8,"title":416,"piName":417,"institution":418,"country":314,"year":13,"amount":14,"abstract":419},"openalex-european-research-council-award-864287-threshold-erc-2019-cog","Decoupled Climatic Drivers of Tree and Ground‐Layer Carbon Uptake in Mountain Ecosystems Around the World","Max Mallen‐Cooper","Swedish University of Agricultural Sciences","One of the key ecological processes affected by climate change is plant carbon uptake. However, there is substantial uncertainty about how plant carbon uptake will respond to warming in mountain ecosystems, which are known for sharp temperature gradients and abrupt shifts in vegetation structure. Specifically, we lack an understanding of whether these response trajectories over time will be linear or non-linear, and how they might vary among mountain ecosystems globally. Here, we measured ecosys",{"id":421,"funder":7,"programme":8,"title":422,"piName":423,"institution":424,"country":425,"year":13,"amount":14,"abstract":426},"openalex-european-research-council-award-erc-cog-2014-649021","Association between the gut microbiota and estimated glomerular filtration rate in two Swedish population-based cohorts","Lin Yi-Ting","Kaohsiung Medical University","TW","INTRODUCTION: Evidence for gut-kidney interactions in early kidney disease is limited, particularly in community-dwelling adults with largely preserved kidney function. Here, we quantified links between gut microbiota and estimated glomerular filtration rate (eGFR) in two population-based Swedish cohorts. METHODS: Deep shotgun metagenomics profiled fecal samples from 9788 adults in the Swedish CArdioPulmonary BioImage Study (SCAPIS) discovery cohort (mean age 58 ± 4 years; 52% women) and 2080 ad",{"id":428,"funder":7,"programme":8,"title":429,"piName":430,"institution":431,"country":93,"year":13,"amount":14,"abstract":432},"openalex-european-research-council-award-erc-2019-cog-864616-healin","The association between employment and family histories and caregiving in later life. European findings based on SHARE and ELSA","Christian Deindl","TU Dortmund University","Caregiving can be time-consuming, and it can be challenging for caregivers to combine caregiving tasks with other obligations. While we know a lot about the problems of combining informal care with employment and family obligations, past employment and family histories are seldom discussed. This study tries to fill this gap by examining the association between employment and family histories and caregiving in later life. We used pooled data from the Survey of Health, Ageing and Retirement in Eur",{"id":434,"funder":7,"programme":8,"title":435,"piName":14,"institution":436,"country":93,"year":13,"amount":437,"abstract":438},"cordis-european-research-council-award-101232119","ENGINEERING MULTIVALENCY FOR SUPERSELECTIVE RECOGNITION OF PATHOGEN TARGETS","TECHNISCHE UNIVERSITAET MUENCHEN","€1,996,846","The recent pandemic has emphasised the need to rapidly develop materials that can detect, inhibit and destroy viruses and other pathogens. Antibodies achieve selective recognition of biological targets at ultralow concentrations via multivalent interactions, i.e. the cooperative binding of multiple sites to cognate receptors. While antibody deployment is ubiquitous in diagnostics and therapy, their animal-based manufacturing is costly, time-consuming, lacks universal applicability and raises eth",{"id":440,"funder":7,"programme":8,"title":441,"piName":14,"institution":442,"country":443,"year":13,"amount":444,"abstract":445},"cordis-european-research-council-award-101230920","New structures in primes and Diophantine approximation","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","UK","€1,995,717","Prime numbers have fascinated mathematicians for centuries, and have given rise to some of the oldest and most notorious open problems. Despite their central status, many fundamental aspects of the primes remain beyond the reach of current techniques.\n\nThis project aims to make progress on central questions related to the distribution of primes. The goal is to develop new versatile techniques that can provide inroads to the fundamental problems at the heart of the subject, building on recent bre",{"id":447,"funder":7,"programme":8,"title":448,"piName":14,"institution":449,"country":443,"year":13,"amount":450,"abstract":451},"cordis-european-research-council-award-101229653","DYE-a-LOG: A Global Reinterpretation of Synthetic Dye History in Non-European Textiles","BRITISH MUSEUM","€2,877,282","DYE-a-LOG bridges the gap between the chemistry of synthetic dyes and the economic, social and cultural implications of their introduction in non-European textile-making practices, offering a new ground-breaking understanding of the complex dynamics underpinning this global phenomenon. It shifts from dominant Eurocentric perspectives that frame the development and spread of synthetic dyes as positive industrial progress to outward-looking narratives that restore agency to the various local and g",{"id":453,"funder":7,"programme":8,"title":454,"piName":14,"institution":455,"country":443,"year":13,"amount":456,"abstract":457},"cordis-european-research-council-award-101232319","Appetite and Obesity: leveraging the power of dog genetics for biomedical insight.","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€1,986,152","Epidemic obesity threatens global health and has been attributed to changes in diet and lifestyle. However, not everyone gains weight in an obesogenic environment. Heritable variation in appetite renders some individuals susceptible to weight gain, but which genes are responsible and why, and what overlap is there between appetite and obesity genes? \n\nI study pet dogs to identify genes and molecular mechanisms underlying obesity, with the overarching aim of reducing the impact of obesity on huma",{"id":459,"funder":7,"programme":8,"title":460,"piName":14,"institution":461,"country":93,"year":13,"amount":462,"abstract":463},"cordis-european-research-council-award-101229483","Manipravalam: Insight, Research, and Analysis","UNIVERSITY OF HAMBURG","€1,999,888","Manipravalam (“pearl and coral”), a blend of Sanskrit and local languages, emerged as a predominant language in the Tamil region during the 2nd millennium. Its unique linguistic character facilitated its role as a bridge-language that transmitted religious knowledge and united multiple religious traditions, inter alia. This language played a crucial role in shaping South India’s linguistic, religious, and cultural landscape during the medieval period. Although primarily associated with medieval ",{"id":465,"funder":7,"programme":8,"title":466,"piName":14,"institution":467,"country":27,"year":13,"amount":468,"abstract":469},"cordis-european-research-council-award-101230608","Gravitational Lensing of Waves","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","€2,185,007","Gravitational lensing provides invaluable insight into astrophysics, cosmology, and fundamental physics. Now, a new frontier is open thanks to observational breakthroughs in gravitational waves (GWs) and fast radio bursts (FRBs). Like visible light, these signals are deflected and magnified by gravitational fields, but their phase coherence exposes wave-optics lensing phenomena: wavefront distortions that can help us identify very distant sources and characterize the intervening matter distribut",{"id":471,"funder":7,"programme":8,"title":472,"piName":14,"institution":473,"country":93,"year":13,"amount":474,"abstract":475},"cordis-european-research-council-award-101230742","Conspiracy Theorizing from South Asia. Formation, Mediatization, and Appropriation.","FREIE UNIVERSITAET BERLIN","€1,999,375","While conspiracy theories (CT) are widely debated as a global phenomenon, case studies from the Global North have largely shaped their definitions. This project aims to expand the field by examining the formation, mediatization, and appropriation of conspiracy theories in South Asia to challenge the dominance of Europe and US-centric perspectives in three ways: (a) Empirically: Positioning South Asia—home to one-quarter of the world’s population—on the map of conspiracy theory studies, we will e",{"id":477,"funder":7,"programme":8,"title":478,"piName":14,"institution":479,"country":314,"year":13,"amount":480,"abstract":481},"cordis-european-research-council-award-101231976","Eliminating Leishmaniasis: Novel Strategies to Prevent Leishmania Transmission and Control Sand Flies through Pharmacological Treatment","UPPSALA UNIVERSITET","€1,999,740","Visceral leishmaniasis (VL), a neglected tropical disease caused by Leishmania parasites, forms a significant health challenge in the Indian subcontinent and Eastern Africa. Despite substantial progress towards elimination, critical challenges persist in the ‘last mile’ to achieve and maintain elimination. I propose the innovative 5-year TRANSPHORM project, where I will develop novel pharmacological strategies to prevent Leishmania transmission and control sand fly vectors. Patients with the ski",{"id":483,"funder":7,"programme":8,"title":484,"piName":14,"institution":485,"country":73,"year":13,"amount":486,"abstract":487},"cordis-european-research-council-award-101229629","Cracking the Host Sugar Code:  Insights into H5Nx Influenza A Virus Adaptation and Pathogenesis","UNIVERSITEIT UTRECHT","€2,000,000","Sugar-Viro will create advanced glycoscience tools to address critical questions in H5Nx influenza A virus (IAV) biology, aiming to enhance surveillance, inform antiviral development, and contribute to the fight against IAV infections. \nTo initiate infection, respiratory pathogens like IAV must interact with complex carbohydrate structures, or glycans, present on the respiratory epithelium. However, virus-glycan interactions remain poorly understood due to the diversity, biosynthetic complexity,",{"id":489,"funder":7,"programme":8,"title":490,"piName":14,"institution":491,"country":192,"year":13,"amount":492,"abstract":493},"cordis-european-research-council-award-101232313","Global study of the macro- and individual-level causes and consequences of loneliness","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","€1,990,901","Loneliness is a universal social phenomenon experienced across the life-course that has implications for the health and well-being of both individuals and societies. Distinct from simply ‘being alone’, loneliness refers to individuals’ assessment of the quantity and quality of their social relationships and this assessment is shaped by social and cultural norms and expectations. Despite the negative assessments that ferment loneliness being shaped by the contexts in which they are made, most res",{"id":495,"funder":7,"programme":8,"title":496,"piName":14,"institution":497,"country":192,"year":13,"amount":486,"abstract":498},"cordis-european-research-council-award-101230066","GENERATION EU (GenEU): The development of European identity and implications for social cohesion and peace","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","Youth in Europe may be the first generation of native EU citizens in their country; their support for and identification with Europe are essential for peace on the continent. Identity formation is an essential development task across the lifespan; yet in middle childhood and early adolescence, there is low identity complexity. Therefore, it is essential to understand how children and adolescents develop and identify with superordinate categories (e.g. being European), and the impact of those ide",{"id":500,"funder":7,"programme":8,"title":501,"piName":14,"institution":502,"country":503,"year":13,"amount":504,"abstract":505},"cordis-european-research-council-award-101232348","Sensing Ecocide: Advancing Accountability for Environmental Atrocity Crimes","NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU","NO","€1,999,830","The entanglement of climate change, extractive projects, and conflict has expanded environmental violence to a planetary scale, complicating causal chains between victims, perpetrators, sources, and impacts. SEECODE aims to address these challenges through artistic research, deepening our understanding of the representational and causal complexities of environmental violence. By focusing on both existing international crimes and the emerging crime of ecocide, or crimes against the environment, S",{"id":507,"funder":7,"programme":8,"title":508,"piName":509,"institution":510,"country":80,"year":13,"amount":14,"abstract":511},"openalex-european-research-council-award-682117-bit-erc-2015-cog","Modeling human synchronization to rhythmic patterns with varying statistical regularities","Dunia Giomo","Scuola Internazionale Superiore di Studi Avanzati","The ability to learn and adapt to new temporal regularities is pivotal to successfully interact with our environment. Research on rhythm processing has identified which features boost the learning of new rhythmic patterns and facilitate predictive behaviors, such as motor synchronization to them. How do humans learn to synchronize with new temporal patterns when these lack strong rhythmicity and predictability? Here we hypothesized that optimal synchronization with such patterns would require a ",{"id":513,"funder":7,"programme":8,"title":514,"piName":14,"institution":515,"country":87,"year":13,"amount":486,"abstract":516},"cordis-european-research-council-award-101230981","Navigating Ethical Dilemmas of Migrant Solidarity","UNIVERSITAT FUR WEITERBILDUNG KREMS","Policymakers and civil society actors in the migration field are often confronted with ethical dilemmas. Yet, no systematic comparative study exists of how these actors respond to ethical dilemmas in real-life circumstances, and we lack a theory to explain their decisions and assess their impact on the actors’ political identity. Focusing on actors engaged in solidarity practices with irregular and precarious migrants, which raise particularly acute dilemmas, MIGSOL therefore asks: When faced wi",{"id":518,"funder":7,"programme":8,"title":519,"piName":14,"institution":520,"country":521,"year":13,"amount":522,"abstract":523},"cordis-european-research-council-award-101229540","Parish Politics in Early Modern East Central Europe, 1650–1800: The Role of Popular Politics in Late Catholic Confessionalization and Early Modern State-Building","ELTE HUMAN TUDOMANYOK KUTATOKOZPONTJA","HU","€1,997,500","Why is our picture of the early modern East Central European popular politics often contradictory, fragmented, and difficult to generalise? The project addresses this question by exploring parish politics as a form of popular politics through which local communities participated in parish matters by creating a local public arena around Catholic parishes. The project examines how local communities influenced late Catholic confessionalization and early modern state building through parish politics",{"id":525,"funder":7,"programme":8,"title":526,"piName":14,"institution":527,"country":443,"year":13,"amount":528,"abstract":529},"cordis-european-research-council-award-101230797","Igusa Stacks and the Langlands program","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€1,999,760","The Langlands program, often called a ``grand unified theory of mathematics'', predicts reciprocity laws that relate very different kinds of mathematical objects: automorphic forms and Galois representations. Shimura varieties play a fundamental role in constructing and propagating instances of Langlands reciprocity.\n\nIn the past decade, advances in p-adic geometry have revolutionised the study of Shimura varieties. This recently led to the introduction of certain p-adic analytic varieties calle",{"id":531,"funder":7,"programme":8,"title":532,"piName":14,"institution":533,"country":12,"year":13,"amount":534,"abstract":535},"cordis-european-research-council-award-101231608","Functional evolution of the cell autonomous innate immunity in mammals","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€2,528,637","Cell-autonomous innate immunity is the first line of defense against pathogens and is crucial in infections, viral cross-species transmissions and autoimmunity. In mammals, it is notably composed of proteins from the interferon pathway inhibiting viruses within infected cells. In turn, viruses evade or antagonize immunity, leading to virus-host evolutionary arms-races. Beyond classic adaptation by site-specific positive selection, we discovered cases of gene duplications with divergence in gene ",{"id":537,"funder":7,"programme":8,"title":538,"piName":539,"institution":14,"country":14,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2018-cog-819093","Stimulus intelligibility impacts L1 effects on L2 visual word recognition","Sara Guediche",{"id":541,"funder":7,"programme":8,"title":542,"piName":14,"institution":442,"country":443,"year":13,"amount":543,"abstract":544},"cordis-european-research-council-award-101230587","ResIntegrate: Integrating and predicting resilience of ecological systems to multiple disturbances","€2,213,026","Ecological systems rarely face disturbances one at a time. Instead, droughts, fires, storms, and human pressures \noften occur together or in rapid succession, interacting in ways that can amplify or dampen their effects. Some \necosystems resist these disturbances or recover quickly, while others collapse or shift into entirely new states. \nUnderstanding why these different outcomes occur is one of the central challenges in ecology and is critical \nfor predicting biodiversity change and sustainin",{"id":546,"funder":7,"programme":8,"title":547,"piName":14,"institution":548,"country":258,"year":13,"amount":549,"abstract":550},"cordis-european-research-council-award-101229121","Charting Infants’ Language, Auditory, and Motor Experiences in Everyday Contexts","TAMPEREEN KORKEAKOULUSAATIO SR","€2,154,090","Infant development, including language, is shaped by infants’ experiences with the external environment. This environment is not a uniform stream of sensory input, but is structured into contexts, activities, and routines that shape the flow of experiences. Gradually developing motor abilities also enable infants to engage with these contexts in new ways, fostering opportunities for learning. Despite their significance, little is known about how the real-world contexts and infants’ own motor dev",{"id":552,"funder":7,"programme":8,"title":553,"piName":14,"institution":554,"country":93,"year":13,"amount":555,"abstract":556},"cordis-european-research-council-award-101230706","Towards An Accurate Measurement of the Lifetime of Ultracold Neutrons Suspended in a Novel Fully Magnetic Trap","JOHANNES GUTENBERG-UNIVERSITAT MAINZ","€1,999,410","The Standard Model (SM) of Particle Physics predicts the free neutron lifetime, τn, as a function of only two input parameters with high precision. Recent theoretical progress now provides a SM description of neutron decay at the 10−4 level. My project, NuLife, will enable a future measurement of τn with 0.1 s accuracy to test these SM predictions at the same unprecedented level through the pioneering development of a novel, large-volume, and deep magnetic trap. Previous measurements with a mate",{"id":558,"funder":7,"programme":8,"title":559,"piName":14,"institution":560,"country":27,"year":13,"amount":561,"abstract":562},"cordis-european-research-council-award-101230200","Precise Computation of Thermal Phase Transition Parameters","UNIVERSIDAD DE GRANADA","€1,801,250","Our understanding of field theories at finite temperature (FTQFT) has undergone significant progress in the last decade. It has been boosted in part by the necessity of correctly interpreting the data from current and future detectors of gravitational waves (GWs) produced during Phase Transitions (PT) in the early and hot Universe. By now it is well established that the correct description is provided by a 3-dimensional Euclidean effective field theory (EFT) involving only those degrees of freed",{"id":564,"funder":7,"programme":8,"title":565,"piName":14,"institution":566,"country":21,"year":13,"amount":567,"abstract":568},"cordis-european-research-council-award-101232287","Unlocking bio-inspired machine hearing and accelerating personalized hearing technologies","UNIVERSITEIT GENT","€1,999,712","As the hearing loss epidemic grows due to an aging population and increasing exposure to urban and recreational noise, the demand for accessible, personalized audio solutions has become more urgent. At the same time, the limitations of speech- and audio-driven systems, such as speech recognition and robotics, are becoming clear. These systems struggle in noisy environments, and consumer electronics for speech and music lack adaptation to individual hearing impairments. To address these challenge",{"id":570,"funder":7,"programme":8,"title":571,"piName":14,"institution":572,"country":87,"year":13,"amount":573,"abstract":574},"cordis-european-research-council-award-101230254","Handcrafted Coalitions: Tantear beyond Borders through Digital Mapping","UNIVERSITAT LINZ","€1,999,183","When we hear about migration and asylum, we usually think of struggles at border crossings, extensive bureaucratic procedures, and the precarious situation of migrants. We rarely think of the objects handcrafted by people on the move, the knowledge these objects entail, what these objects make possible, and the stories these objects tell about the journeys of people on the move. HANDigiCRAFT takes an innovative step by paying attention to objects handcrafted by people on the move and the relatio",{"id":576,"funder":7,"programme":8,"title":577,"piName":14,"institution":578,"country":258,"year":13,"amount":579,"abstract":580},"cordis-european-research-council-award-101230145","Understanding how nature reshapes human sense of time to foster well-being and sustainable futures","TURUN YLIOPISTO","€1,983,773","Time is a central dimension of the human experience; our perception of time influences how we feel and act upon the world. A growing number of people living in fast-paced urban environments report feelings of time scarcity, which have been associated with risky behaviours and poor well-being. Yet, mounting evidence suggests that nature experiences can regulate how urban dwellers perceive time, positively impact their well-being, and promote more sustainable behaviours. This raises the thought-pr",{"id":582,"funder":7,"programme":8,"title":583,"piName":14,"institution":584,"country":258,"year":13,"amount":585,"abstract":586},"cordis-european-research-council-award-101231734","Past-aware material networks towards tomorrow’s textile robots","AALTO KORKEAKOULUSAATIO SR","€1,999,578","Textile Past-a-Bots will materialize future’s interaction interfaces between humans, other species, machines, and their environment. The foundations for this will be done by crafting active yarns into functional textile motifs, for simple sensing, computing, change in dimensions or in mechanical properties. Past-a-Bots can be dynamically assembled using these motifs, integrating the ability to detect sounds, vibrations, and proximity. The multi-sensorial functionalities allow for an ecocentric a",{"id":588,"funder":7,"programme":8,"title":589,"piName":14,"institution":590,"country":503,"year":13,"amount":591,"abstract":592},"cordis-european-research-council-award-101123972","Global Hydroconnectivities beyond Oceans, Seas and Rivers","CHR MICHELSENS INSTITUTT FOR VIDENSKAP OG ANDSFRIHET STIFTELSE","€2,263,509","HydroConnect focuses on the connectivities afforded by hidden, underground fresh water that surfaces along the coastlines of islands lacking accessible, perennial fresh water. It explores how Austronesian-speaking seafarers transformed such freshwater ‘seeps’ into wells throughout the South China Sea and Indo-Pacific, affording sea-routes around these well networks. Thus, HydroConnect breaks with the tendency in the social sciences and historiography to analytically privilege oceans or navigable",{"id":594,"funder":7,"programme":8,"title":595,"piName":14,"institution":596,"country":443,"year":13,"amount":597,"abstract":598},"cordis-european-research-council-award-101231314","High-Performance Pressure-Free Silicon All-Solid-State Batteries by Integrated Physical and Digital Twin Techniques","QUEEN MARY UNIVERSITY OF LONDON","€1,999,992","Silicon (Si) presents a promising advancement over current graphite electrodes for high-energy automotive batteries, offering a tenfold greater capacity (3579 mAh g⁻¹). However, its application is hindered by substantial volume changes during charge\u002Fdischarge cycling that causes rapid degradation. Overcoming this challenge is pivotal to achieve a climate-neutral society.Redefining the conventional paradigm, TWIN-SiNERGY aims to deliver a transformative separator-free monolithic Si all-solid-stat",{"id":600,"funder":7,"programme":8,"title":601,"piName":14,"institution":602,"country":603,"year":13,"amount":604,"abstract":605},"cordis-european-research-council-award-101230369","Tracking Polluted Clouds: the Plausibility of a Strong Aerosol Cooling Effect on Earth’s Climate","TARTU ULIKOOL","EE","€1,998,875","Anthropogenic climate change is a tug-of-war with fossil fuels playing both sides of the field. Fossil fuel use emits both climate-warming greenhouse gases and climate-cooling aerosols. And aerosol impacts on clouds might have thus far masked a large fraction of greenhouse gas warming. If the aerosol cooling is strong, it implies 1) that the Earth’s climate is more sensitive to anthropogenic greenhouse gases than currently thought, and 2) reduced aerosol pollution has brought forward global warm",{"id":607,"funder":7,"programme":8,"title":608,"piName":14,"institution":609,"country":12,"year":13,"amount":610,"abstract":611},"cordis-european-research-council-award-101229769","Theory and numerics for electronic structure","UNIVERSITE PARIS-SACLAY","€1,223,750","Electronic structure methods allow for the simulation of molecules and materials from first principles. Among these methods, Kohn-Sham density functional theory (DFT) stands out for its balance between computational cost and accuracy. Mathematically, it is a system of coupled nonlinear partial differential equations with an interestinggeometrical structure. DFT is enormously popular in applications to physics, chemistry, materials science and biology. However, it suffers from a lack of robustnes",{"id":613,"funder":7,"programme":8,"title":614,"piName":14,"institution":615,"country":93,"year":13,"amount":616,"abstract":617},"cordis-european-research-council-award-101230038","Interacting open synthetic dimensions systems","UNIVERSITAT KONSTANZ","€1,998,985","Recent technological advances are propelling the field of quantum simulation, with pioneering light-matter experiments in electronic, cold-atomic, and photonic systems. These developments enable the creation of systems with “synthetic dimensions”, where observable effects emerge from dimensions higher than that of the physical experimental setup. Such systems are inherently out of equilibrium, as synthetic dimensions arise from parametric drives that couple internal degrees of freedom or adiabat",{"id":619,"funder":7,"programme":8,"title":620,"piName":14,"institution":621,"country":93,"year":13,"amount":622,"abstract":623},"cordis-european-research-council-award-101229453","Deciphering the logic of representational drift and its conversion to stable readouts.","UNIVERSITAT DES SAARLANDES","€1,990,625","We perceive the world around us as constant. When we engage in the same action over days and weeks, for instance when we walk down a familiar road, it feels the same every day. Neurons build a model (or representation) of the external world that is thought to guide behaviour. However, neural representations change over time, leading to a restructured model of the world. This phenomenon, called representational drift, has been identified across a range of brain regions and behaviours, and poses a",{"id":625,"funder":7,"programme":8,"title":626,"piName":14,"institution":627,"country":628,"year":13,"amount":486,"abstract":629},"cordis-european-research-council-award-101231057","Fair-Weather Finance: Historical Antecedents of Climate Risk Management","UNIVERSITAT ZURICH","CH","The insurance and reinsurance sectors, including institutions such as Lloyd’s of London, Swiss Re, and Munich Re, assert that they have the necessary instruments to address devastating weather events and climate catastrophe. In order to develop appropriate risk management instruments to protect against disruptive natural events, insurance companies have been conducting their own forms of research on weather and climate since the latter half of the eighteenth century. Over the past several decade",{"id":631,"funder":7,"programme":8,"title":632,"piName":14,"institution":627,"country":628,"year":13,"amount":633,"abstract":634},"cordis-european-research-council-award-101229803","Conceptual diversity and the evolution of abstract thought","€1,998,750","Human cultural evolution Human cultural evolution is often traced via ancient pot-shards, cave paintings and ritualistic traditions. But a greater challenge is to unravel the abstract concepts behind these physical traces. Cultural evolution involves not just artefacts and practices, but also the transmission of conceptual structures – ways of mentally representing the world – with continuous intergenerational transmission over thousands of years. Cultural areas in distinct parts of the world ha",{"id":636,"funder":7,"programme":8,"title":637,"piName":14,"institution":627,"country":628,"year":13,"amount":638,"abstract":639},"cordis-european-research-council-award-101232098","Rethinking Copyright Policy in the Digital Age: Balancing Incentives for Creation and Access","€1,983,075","Copyrights are a key driver of the creative industries and a cornerstone of modern economic activity. At its core, copyright protection must balance a fundamental trade-off between encouraging investment in creative products and ensuring their access. Weak copyright protection risks undermining creators' incentives to innovate, while overly strong protection can discourage the dissemination of ideas. Despite its crucial importance, we empirically know very little about the optimal level of copyr",{"id":641,"funder":7,"programme":8,"title":642,"piName":14,"institution":643,"country":73,"year":13,"amount":486,"abstract":644},"cordis-european-research-council-award-101229280","Understanding the specialized function of human neurons and circuits","STICHTING VU","Human cognition stands out from other species, but how neurons and circuits in the human brain support cognition is poorly understood. Our recent work showed that human brain holds specialized neuron types – pyramidal neurons in cortical layer 3 (L3 PNs) – with distinct properties that associate with IQ scores. In the human brain, L3 PNs form circuits with each other and another human-specialized interneuron type, double bouquet cell (DBC). These circuits might be critical for human cognition as",{"id":646,"funder":7,"programme":8,"title":647,"piName":14,"institution":648,"country":93,"year":13,"amount":486,"abstract":649},"cordis-european-research-council-award-101230491","COMpilers for ExTreme Heterogeneity","TECHNISCHE UNIVERSITAET DRESDEN","Computing has become a key pillar of many areas in society and science. For decades, the ever-increasing complexity of computing systems has been hidden via incremental advances in programming abstractions, compilers and runtimes environments. Underlying these abstractions is the 8-decade old von Neumann Computing (vNC) model. The demise of scaling laws in electronics, however, has sparked disruption in devices and Hardware (HW) architectures, leading to novel Non-von Neumann Computing (NvNC) pa",{"id":651,"funder":7,"programme":8,"title":652,"piName":14,"institution":653,"country":27,"year":13,"amount":654,"abstract":655},"cordis-european-research-council-award-101230198","Astrocytic Metabolic Reprogramming as a Therapeutic Target for Alzheimer’s Disease","UNIVERSIDAD DE NAVARRA","€1,999,637","Alzheimer's disease (AD) represents a growing public health challenge, with its prevalence steadily increasing profoundly affecting both patients and their families. Despite extensive research focusing on amyloid-beta and tau as central pathological hallmarks of AD, the crucial role of astrocytic metabolism in neurodegeneration has often been overlooked. The HyperAstroMet project introduces a novel approach by investigating astrocytic hypermetabolism as a pivotal driver of neuronal hyperexcitabi",{"id":657,"funder":7,"programme":8,"title":658,"piName":14,"institution":659,"country":503,"year":13,"amount":660,"abstract":661},"cordis-european-research-council-award-101229710","In\u002Fvisible women of the sea. Gendering fishery politics and advocacy","UNIVERSITETET I BERGEN","€1,995,107","Fishery is commonly conceived of as a “man’s world”, even if women comprise half of the fisheries and aquaculture work force value chain globally. Gender inequality is a persistent feature of the fishery sector, despite attention to the issue by scholars, policy advocates, and in some countries; public officials and fisher women themselves. The GENMAR-project will fill substantial empirical and theoretical knowledge in our understanding of why and how women are continuously marginalized in fishe",{"id":663,"funder":7,"programme":8,"title":664,"piName":14,"institution":665,"country":93,"year":13,"amount":666,"abstract":667},"cordis-european-research-council-award-101230109","Botanical Legacies: Towards a New History and Philosophy of Virtual Herbaria","RUHR-UNIVERSITAET BOCHUM","€1,999,500","This project sets the foundation for a more inclusive, theoretically sound, and socially just botany of the 21st century. Herbaria hold ca. 400 million preserved plant specimens worldwide. They are vital repositories of botanical and environmental knowledge. However, chronic underfunding has made much of this knowledge inaccessible. Recent digitization efforts for ‘virtual herbaria’ are believed to change this, as they expand accessibility and trigger new studies in herbarium genomics and AI-dri",{"id":669,"funder":7,"programme":8,"title":670,"piName":14,"institution":671,"country":672,"year":13,"amount":673,"abstract":674},"cordis-european-research-council-award-101231746","Reimagining Schools Through a Post-Disaster Lens","INSTITUT ZA DRUSTVENA ISTRAZIVANJA U ZAGREBU","HR","€1,977,855","Reimagining Schools through a Post-Disaster Lens (RESADL) will take the lead in affirming the field of educational research on disasters in Europe. It will fill a major lacuna in empirical research on education and disasters: the lack of a holistic perspective on school roles in post-disaster settings, and the conditions shaping them. Its overarching questions are: What school roles are suspended, enacted, contested and imagined in post-disaster settings, and what accounts for their convergences",{"id":676,"funder":7,"programme":8,"title":677,"piName":14,"institution":678,"country":93,"year":13,"amount":679,"abstract":680},"cordis-european-research-council-award-101231446","Time-varying metaphotonics via reverse engineering","GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER","€1,999,996","Among the most transformative frontiers in nanophotonics are time-varying materials, whose optical properties can be dynamically modulated on femtosecond to picosecond timescales in response to external stimuli, such as light pulses, enabling ultrafast control over light-matter interactions. These materials hold the promise to enable the next generation of dynamic and tunable metaphotonic devices with reprogrammable functionalities. Transparent conductive oxides belong to this category of materi",{"id":682,"funder":7,"programme":8,"title":683,"piName":14,"institution":684,"country":443,"year":13,"amount":685,"abstract":686},"cordis-european-research-council-award-101230720","PROtecting access to the SPace Environment by assessing the Risks of space debris","UNIVERSITY OF KENT","€2,878,795","Our ever-expanding use of, and dependence on, space is under threat from space debris – objects resulting from our activities beyond Earth and ranging in size from flecks of paint to whole rocket stages. These pose an impact hazard to orbiting satellites and, ultimately, the continued safe access to space. De-orbiting objects into the atmosphere is also a potential pollution risk. This is thus an anthropogenic, technological geohazard in the near Earth environment arising from aerospace engineer",{"id":688,"funder":7,"programme":8,"title":689,"piName":14,"institution":690,"country":12,"year":13,"amount":691,"abstract":692},"cordis-european-research-council-award-101230190","Characterisation Of Rhizaria in modern Oceans: from living cells to fossils","UNIVERSITE DU LITTORAL","€2,600,000","Can we simultaneously learn from past, present, and future oceans by studying plankton? For 521 million years, Rhizaria have abundantly and ubiquitously populated all oceans from the surface to the deep. They have biomineralised intricate skeletons by using silicon, thus impacting marine biogeochemical cycles. Upon death, their skeletons can become fossils and reflect ancient planktonic life. Yet, do fossils reflect all Rhizaria populations living in the water column? What is the fate of some la",{"id":694,"funder":7,"programme":8,"title":695,"piName":14,"institution":696,"country":73,"year":13,"amount":697,"abstract":698},"cordis-european-research-council-award-101229735","Mnemonic and predictive influences on sensory processing: mapping the neural computations","UNIVERSITEIT MAASTRICHT","€1,999,462","Processing the present (perception) is shaped by past experiences (memory) and current expectations of future events (prediction). The Bayesian brain hypothesis formalizes this idea, positing that living agents maintain a model of the world, built upon memories and entailing predictions of likely causes of sensations. Prediction is mediated by multiple brain regions such as sensory neocortex and the hippocampus, and my research has pinpointed several neural mechanisms of prediction across task c",{"id":700,"funder":7,"programme":8,"title":701,"piName":14,"institution":702,"country":521,"year":13,"amount":703,"abstract":704},"cordis-european-research-council-award-101231345","Descriptive Complexity in the Finite and Infinite","EOTVOS LORAND TUDOMANYEGYETEM","€1,855,274","We propose to study infinite, definable (Borel, measurable, etc.) graphs and structures and their interplay with finite ones from the perspective of descriptive complexity. Our focus will be on the following three directions:-Determining the descriptive complexity of constraint satisfaction problems (CSPs), or, equivalently, homomorphism problems on infinite domains. -Analyzing the concept of Borel hyperfiniteness of graphs and establishing new examples of non-hyperfinite graphs using methods fr",{"id":706,"funder":7,"programme":8,"title":707,"piName":14,"institution":554,"country":93,"year":13,"amount":708,"abstract":709},"cordis-european-research-council-award-101231894","Search for Double Beta Plus Decays with a Novel Detector Concept Combining Hybrid and Opaque Scintillator Techniques","€1,999,892","The pre-dominance of ordinary matter over anti-matter in the observable universe is one of the major unsolved questions of cosmology. Without this so-called baryon asymmetry (BA) the universe would be a void. An avenue to explain BA is through the discovery of a process that violates the number of leptons (LNV). Prime candidate is the neutrinoless double beta decay (0n2b). While in ordinary double beta decays (2n2b) two nucleons simultaneously decay in two charged leptons and two neutrinos, in 0",{"id":711,"funder":7,"programme":8,"title":712,"piName":14,"institution":602,"country":603,"year":13,"amount":713,"abstract":714},"cordis-european-research-council-award-101231008","Understanding Women’s Health Through the Lens of Hormonal Sensitivity: Genetics, Mechanisms and Health Trajectories","€1,863,125","Hormonal sensitivity conditions such as premenstrual syndrome, hormonal medication side effects, and (peri)menopausal symptoms affect billions of women but remain poorly understood. These conditions share a common factor: fluctuations in estrogen and progesterone levels that interact with endocrine, neurological, and metabolic systems, creating a continuum of individual hormone sensitivity. UNDERwHER aims to redefine the hormone sensitivity spectrum (HSS) by addressing its biological underpinnin",{"id":716,"funder":7,"programme":8,"title":717,"piName":14,"institution":718,"country":93,"year":13,"amount":719,"abstract":720},"cordis-european-research-council-award-101230140","Atomically engineered core-shell OER catalysts from free‐standing oxide membranes","FORSCHUNGSZENTRUM JULICH GMBH","€1,997,951","Major efforts in recent years to develop catalysts for the oxygen evolution reaction (OER) have shown that perovskites and spinels have significant catalytic activity, making them a promising materials class for water-splitting for hydrogen production. However, so far these complex oxides have displayed limited stability, which prevents realizing their potential. This activity-stability dilemma is compounded by the fact that most progress on ‘rational catalyst design and property engineering’ so",{"id":722,"funder":7,"programme":8,"title":723,"piName":14,"institution":724,"country":27,"year":13,"amount":725,"abstract":726},"cordis-european-research-council-award-101171809","A multi-ingredient brain function model predicting chronic pain in youth: a window into future well-being","UNIVERSITAT DE BARCELONA","€1,998,081","Chronic pain is endemic and difficult to treat. The first surge occurs in adolescence, a critical period for brain development associated with high vulnerability. The number of adolescents with disabling pain has soared, and in most cases, pain persists into adulthood, strongly impacting long-term wellbeing. The impact of chronic pain in adolescence urgently calls for a better understanding of its causes, longitudinal predictors, and underlying biopsychosocial mechanisms. Psychosocial and physic",{"id":728,"funder":7,"programme":8,"title":729,"piName":14,"institution":730,"country":21,"year":13,"amount":666,"abstract":731},"cordis-european-research-council-award-101232340","Theory of nonradiative decay with two or more electrons at play","KATHOLIEKE UNIVERSITEIT LEUVEN","UNBOUND TWO aims to develop the quantum chemistry methods that are needed to interpret next-generation spectroscopy involving two or more unbound electrons and to understand chemical reactions involving unbound doubly-excited states. Emerging spectroscopies can probe correlations between two electrons, which is fundamentally impossible with techniques that probe only one electron. To gain information about electronic and molecular structure from such spectra, theoretical modeling is key. However",{"id":733,"funder":7,"programme":8,"title":734,"piName":14,"institution":735,"country":628,"year":13,"amount":486,"abstract":736},"cordis-european-research-council-award-101229912","The Vicious Cycle of Inequality: How Economic Inequality Perpetuates Itself by Creating a Culture of Competitiveness in Schools","UNIVERSITE DE LAUSANNE","The perpetuation of income and wealth inequality across generations threatens the foundations of a fair and stable society. This project investigates the novel idea that economic inequality perpetuates itself by creating a culture of competitiveness among children and adolescents in schools. I propose that contexts of economic inequality increase the importance of status, leading parents and teachers to encourage students to be more competitive. While students from advantaged families often exce",{"id":738,"funder":7,"programme":8,"title":739,"piName":14,"institution":740,"country":80,"year":13,"amount":741,"abstract":742},"cordis-european-research-council-award-101229235","A Forgotten Renaissance: The Interplay between Jurisprudence and Humanism (14th-16th c.) and Its Cultural Legacy","UNIVERSITA DEGLI STUDI DI TORINO","€1,796,643","From the 14th to the 16th centuries, European jurists and humanists worked in the same social milieu, competed for the same political roles, and often shared the same education. Yet, the scholarly consensus portrays these professional groups as indifferent or hostile to one another. HumanLaw challenges this view by revealing a network of mutual influence between jurists and humanists so extensive and significant that its continued oversight is striking.Integrating philosophical, historical, phil",{"id":744,"funder":7,"programme":8,"title":745,"piName":14,"institution":746,"country":80,"year":13,"amount":747,"abstract":748},"cordis-european-research-council-award-101230916","Dynamics of Deep Earthquakes","UNIVERSITA DEGLI STUDI DI PADOVA","€1,947,405","Deep earthquakes (>70km) are a puzzling yet insufficiently understood process occurring inside the Earth. Despite their potential for significant magnitudes (up to 9) and associated hazards, their physics remains elusive. The theoretical inhibition of earthquakes with increasing temperature and pressure at depth contrasts with over a century of observed occurrences, prompting the persistent question: What causes deep earthquakes? We argue that to tackle this question we need a methodological shi",{"id":750,"funder":7,"programme":8,"title":751,"piName":14,"institution":752,"country":314,"year":13,"amount":486,"abstract":753},"cordis-european-research-council-award-101230127","Breaking the membranous refuge of intracellular bacteria","UMEA UNIVERSITET","Many clinically important pathogens invade human cells and evade their intrinsic defenses by hiding within pathogen-containing vacuoles (PCVs). Hence, it may be feasible to combat such microbes by deliberately destabilizing their PCVs. To promote progress towards such an innovative therapeutic concept, I propose a 5-year research program in which my team will generate a molecular mechanistic understanding of how the PCV is maintained, how it can be destabilized, and how the consequences of PCV d",{"id":755,"funder":7,"programme":8,"title":756,"piName":14,"institution":757,"country":443,"year":13,"amount":758,"abstract":759},"cordis-european-research-council-award-101228968","Quantifying the limits of early life through the biogeochemical phosphorus redox cycle","THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS","€1,992,461","What limited the size of Earth’s early biosphere? Answering this question has critical implications for constraining the pace of early evolution and the habitability of other terrestrial planets. Previous studies have suggested that the early biosphere was limited by metabolic energy, specifically the supply of electron donors. This proposition implies that phosphorus (P) and nitrogen (N) – the key biolimiting nutrients today – were available in excess. However, current estimates of dissolved P ",{"id":761,"funder":7,"programme":8,"title":762,"piName":14,"institution":665,"country":93,"year":13,"amount":763,"abstract":764},"cordis-european-research-council-award-101229656","The Attribute Frequency Model: Understanding and Mitigating Biases in Social Perception","€1,969,250","I introduce the Attribute Frequency Model (AFM), a novel theoretical framework to explain biases in human social perception. The AFM posits that the frequency of observed individuals’ or groups’ attributes influences social perceptions of similarity, (in-)equality, and valence. Rare attributes amplify perceived differences, inequalities, and negativity among social groups, while frequent attributes emphasize similarities, equality, and positivity. The model assumes that humans lack the meta-cogn",{"id":766,"funder":7,"programme":8,"title":767,"piName":14,"institution":768,"country":87,"year":13,"amount":769,"abstract":770},"cordis-european-research-council-award-101228762","Hyperpolarized Surface-enhanced Liquid-State Spectroscopy","UNIVERSITAT WIEN","€1,998,020","Across science, medicine, and industry, nuclear magnetic resonance (NMR) is a key technique with the unique capacity to provide atomistically detailed molecular models. Its primary drawback, however, lies in its low sensitivity, limiting its ability to address critical scientific questions. A potential answer is hyperpolarization via dissolution dynamic nuclear polarization (dDNP), which can amplify NMR sensitivity 10,000-fold. Despite this promise, dDNP remains a niche method constrained to a n",{"id":772,"funder":7,"programme":8,"title":773,"piName":14,"institution":774,"country":93,"year":13,"amount":775,"abstract":776},"cordis-european-research-council-award-101230645","Decoding bacterial immunity to enhance antimicrobial action","EBERHARD KARLS UNIVERSITAET TUEBINGEN","€1,999,986","The rise of antibiotic resistance demands new strategies to combat bacterial infections. With renewed interest in phage-bacteria interactions, over 150 novel phage defence systems were recently identified, most of which protect bacteria from propagating phages via host-regulated death or growth arrest in an abortive infection process (Abi). Abi systems, encoded primarily on mobile genetic elements, exhibit diverse mechanisms and are pervasive in bacteria. However, despite significant mechanistic",{"id":778,"funder":7,"programme":8,"title":779,"piName":14,"institution":780,"country":781,"year":13,"amount":782,"abstract":783},"cordis-european-research-council-award-101230549","Towards a unified structure theory for dense graphs","UNIWERSYTET WARSZAWSKI","PL","€1,997,863","The fields of graph algorithms and of structural graph theory enjoy a particularly fruitful symbiosis, marked by a rich exchange of techniques, concepts, and inspirations. At this point, structural graph theory provides a comprehensive toolbox for the treatment of sparse graphs. Compared to this, our understanding of dense graphs is much more fragmented and incomplete. Motivated by a recent wave of advances in this topic, we propose to launch a systematic investigation of links between the exist",{"id":785,"funder":7,"programme":8,"title":786,"piName":14,"institution":787,"country":443,"year":13,"amount":788,"abstract":789},"cordis-european-research-council-award-101229657","Transforming the study of radicals in chemical kinetics and beyond","THE UNIVERSITY OF LIVERPOOL","€2,807,248","Gas-phase radicals (atoms or molecules with an unpaired electron) are hugely influential in numerous areas of research. Radicals are responsible for much of the chemistry occurring in the atmosphere, the interstellar medium, in plasmas, and in combustion processes. However, very few existing experimental methods can measure gas-phase radical processes under controlled conditions, resulting in significant unanswered questions across multiple fields. For example, our understanding of atmospheric c",{"id":791,"funder":7,"programme":8,"title":792,"piName":14,"institution":793,"country":27,"year":13,"amount":794,"abstract":795},"cordis-european-research-council-award-101171591","Unveiling human astrocyte states, functions  and their contribution to Alzheimer´s disease","ACHUCARRO BASQUE CENTER FOR NEUROSCIENCE FUNDAZIOA","€1,999,875","The pathogenesis of Alzheimer´s disease (AD) is not fully understood and no cure is available so far. Current therapeutic targets are insufficient and there is an urgent need for finding new pathways and mechanisms and novel targets to treat this terrible disease. Due to critical species-specific differences and the limitations of rodent models of AD, humanized models are necessary to capture the complexity of the disease process. My lab has pioneered the use of humanized chimeric mice to study ",{"id":797,"funder":7,"programme":8,"title":798,"piName":14,"institution":768,"country":87,"year":13,"amount":799,"abstract":800},"cordis-european-research-council-award-101230862","Secondary Pseudepigraphy: Claimed Apostolically-Connected Authors and the Reception of Early Christian Literature","€1,999,313","The CLAIM Project studies the late antique and medieval practice of assigning an apostolic connection to a series of writings composed under the name of early Christian characters like Dionysius the Areopagite, Clement of Rome, Ignatius of Antioch and others, thought to have met central apostolic figures like Paul, Peter, or John. Unlike similar apocryphal works (attributed to the apostles themselves and implicitly claiming their direct authority), this broadly transmitted literature draws on a ",{"id":802,"funder":7,"programme":8,"title":803,"piName":14,"institution":643,"country":73,"year":13,"amount":804,"abstract":805},"cordis-european-research-council-award-101171144","The Collective Bystander","€1,999,181","The public myth about passive bystanders originated 50 years ago with the case of Kitty Genovese, a young woman raped and murdered in New York. Reporters claimed 38 people witnessed the crime but did nothing to help her. Although the police case file later showed that some bystanders in fact had tried to help, the incident inspired decades of experimental studies trying to explain why bystanders in the presence of others remain inactive toward persons in need of help. While this ‘bystander effec",{"id":807,"funder":7,"programme":8,"title":808,"piName":14,"institution":809,"country":628,"year":13,"amount":810,"abstract":811},"cordis-european-research-council-award-101230846","Dissecting the Contributions  of Neurogenesis-Defined Subpopulations  of Hippocampal Neurons to Balancing Memory Stability and Malleability","UNIVERSITAT BASEL","€1,998,917","The ability to update memories underpins adaptive behaviours, ensuring that our internal models of the world remain consistent with the dynamic environments we inhabit. Striking a balance between memory stability (the persistence and robustness of memories over time) and malleability (the capacity to update memories in response to new information) is thus essential to learn from experience and adapt to change. While the biological foundations of memory stability are increasingly understood, the ",{"id":813,"funder":7,"programme":8,"title":814,"piName":14,"institution":815,"country":314,"year":13,"amount":486,"abstract":816},"cordis-european-research-council-award-101232423","Mapping White Adipose Tissue lipid UPtake to cardiovascular disease initiation","KAROLINSKA INSTITUTET","Obesity is associated with adipose tissue dysfunction and greatly increased risk for developing not only metabolic pathologies but also cardiovascular disease (CVD). While insulin resistance and adipose-derived cytokines are established drivers of vascular dysfunction and atherosclerosis initiation, the direct contribution of changes in white adipose tissue (WAT) lipid uptake on vascular health has remained unresolved, yet would open up novel treatment opportunities. My lab has built an arsenal ",{"id":818,"funder":7,"programme":8,"title":819,"piName":14,"institution":455,"country":443,"year":13,"amount":820,"abstract":821},"cordis-european-research-council-award-101229997","Revealing Cosmic Structure Growth and the Early Universe with the CMB Backlight","€1,999,781","With pioneering measurements of Cosmic Microwave Background (CMB) gravitational lensing and scattering, this project will address two of the most important questions in cosmology.Do we understand how cosmic structure grows over time? The growth of large-scale structure with time is one of the most powerful tests of our standard cosmological model and of new physics. Intriguingly, claims of tensions between observations of structure growth and standard model predictions persist. By measuring CMB ",{"id":823,"funder":7,"programme":8,"title":824,"piName":14,"institution":825,"country":314,"year":13,"amount":826,"abstract":827},"cordis-european-research-council-award-101231135","Large-scale disruptions to animal migration","LUNDS UNIVERSITET","€1,719,761","This project will use state-of-the-art monitoring and experiments to investigate how animal migration is controlled, how animals use cues, and factors that govern migratory behaviour. I will do this by taking the novel approach of focusing on three large-scale disruptors that migrants can encounter on their journeys; artificial light, magnetic storms and extreme temperatures, and use the effect of these disruptors on both the individual and system level to discover how sensitive migratory behavi",{"id":829,"funder":7,"programme":8,"title":830,"piName":14,"institution":831,"country":45,"year":13,"amount":832,"abstract":833},"cordis-european-research-council-award-101231721","Using Motor Learning to Establish a Scientific Foundation for Mapping Techniques in Virtual Reality","KOBENHAVNS UNIVERSITET","€1,998,401","The distinctive potential of Virtual reality (VR) is to give people experiences of being in worlds they otherwise could not be in, having a body that is unlike their real one, and doing things they could not do in real life. That potential can be realised with VR interaction techniques that map the movements of the physical body to a virtual one–mapping techniques. Despite over two decades of research on mapping techniques, there is no scientific foundation for developing them. As a consequence,",{"id":835,"funder":7,"programme":8,"title":836,"piName":14,"institution":485,"country":73,"year":13,"amount":837,"abstract":838},"cordis-european-research-council-award-101231578","Biological functions made printable:  smart bioprinting with agency and control  over cell fate and human tissue development","€2,312,492","Three-dimensional bioprinting holds the promise to transform medicine and biology by assembling living matter into lab-made human tissues. Today’s bioprinting excels at producing anatomical shapes, to an extent unmatched by other technologies. However, in native tissues, biological function is intimately linked to architecture, but also tissue maturation and morphogenesis, processes that dynamically evolve as cells respond to environmental stimuli. Bioprinting has no way to follow maturation ove",{"id":840,"funder":7,"programme":8,"title":841,"piName":14,"institution":842,"country":443,"year":13,"amount":843,"abstract":844},"cordis-european-research-council-award-101231030","Duality approach to non-equilibrium quantum matter","THE UNIVERSITY OF BIRMINGHAM","€1,979,558","The systematic understanding of equilibrium collective phenomena through the principles of symmetry and scale is one of the landmark achievements of last century's theoretical physics. The present day analogue is to deduce the laws governing the collective phenomena occurring out of equilibrium, and their basic organising principles, with particular attention to those in complex quantum systems. Solving this problem requires us to overcome the monumental obstacle represented by the lack of gener",{"id":846,"funder":7,"programme":8,"title":847,"piName":14,"institution":848,"country":21,"year":13,"amount":849,"abstract":850},"cordis-european-research-council-award-101228904","Scalable superconducting Qubit readout with millikelvin detection","INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM","€2,862,076","Quantum computing is a game-changing technology that has the potential to revolutionize the way we approach computing and problem-solving. These last years, research groups around the world have made great strides in building quantum computers. One of the most promising is superconducting quantum technology, based on superconducting quantum bits (qubits). While plans to reach quantum computers with hundreds of qubits are in motion, the current technology is not yet scalable to sizes required for",{"id":852,"funder":7,"programme":8,"title":853,"piName":14,"institution":854,"country":80,"year":13,"amount":855,"abstract":856},"cordis-european-research-council-award-101230597","Towards non-invasive and cost-effective digital twin solutions for cardiac electromechanics","UNIVERSITA DEGLI STUDI DI TRENTO","€1,790,587","Cardiac digital twinning is emerging as a cornerstone of precision cardiology, creating patient-specific digital replicas of the heart that integrate anatomy and electromechanical function. These cardiac digital twins (CDTs) promise personalised therapy and improved outcomes. However, current CDT technologies depend on high-quality imaging and electrocardiographic data, limiting their applicability to a small subset of cases.Cardiorama aims to revolutionise CDTs by enabling anatomical and functi",{"id":858,"funder":7,"programme":8,"title":859,"piName":14,"institution":860,"country":73,"year":13,"amount":486,"abstract":861},"cordis-european-research-council-award-101232243","Entropy-driven model reduction for fluid flows","STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN","Turbulent fluid flows play a critical role in science and engineering in energy, process design, climate and life sciences. Accurate and efficient computational fluid dynamics (CFD) simulation tools are therefore essential. As resolving all turbulent scales of motion is computationally infeasible, every CFD code requires a closure model to represent the effect of unresolved scales. A recent paradigm shift is to construct closure models by combining physics- and data-driven methods. However, thes",{"id":863,"funder":7,"programme":8,"title":864,"piName":14,"institution":825,"country":314,"year":13,"amount":486,"abstract":865},"cordis-european-research-council-award-101232162","Assembling the building blocks of advanced color and polarization vision","The natural lightscape is awash in a wealth of visual information that animal eyes have evolved to interpret and exploit. Often, they possess visual capabilities beyond our own, including perception of additional colors (wavelengths) or the polarization of light (the orientation of light waves - an entirely separate visual modality we have no sensitivity to). However, little is known about how these advanced visual systems evolved. I hypothesize that they emerged from segregated information chan",{"id":867,"funder":7,"programme":8,"title":868,"piName":14,"institution":869,"country":73,"year":13,"amount":870,"abstract":871},"cordis-european-research-council-award-101229539","Dealing With Distrust: How Public Organizations Respond To Conspiracy Theories.","UNIVERSITEIT VAN AMSTERDAM","€1,999,272","How do public organizations respond to rising levels of popular distrust fueled by conspiracy theories? Many European citizens no longer trust their own societal institutions to work for the public good, but imagine those to be governed by a shadowy cabal with nefarious motives. While there is much research on conspiracy theories, there is little, if any, academic knowledge on how these institutions deal with rising levels of conspiratorial distrust. This clear knowledge gap is all the more surp",{"id":873,"funder":7,"programme":8,"title":874,"piName":14,"institution":869,"country":73,"year":13,"amount":875,"abstract":876},"cordis-european-research-council-award-101231074","Firms and Careers:  How the Workplace Structures  Career Inequality","€1,999,813","Over the past decades, economic inequality has increased in most societies, threatening social cohesion and limiting opportunities for many. Recent studies highlight the workplace—or firm—as a core arena where this inequality is generated. However, our understanding of the mechanisms by which firms affect inequality remains limited. Moreover, research that examines this relationship compares workers at one point in time, neglecting how firms shape careers.FIRMS addresses these critical gaps. It ",{"id":878,"funder":7,"programme":8,"title":879,"piName":14,"institution":880,"country":27,"year":13,"amount":881,"abstract":882},"cordis-european-research-council-award-101171295","It takes three to tango: semiconductors with three bands for a new generation of optoelectronic devices","UNIVERSITAT POLITECNICA DE CATALUNYA","€2,715,696","Semiconductors, halfway between metals and insulators, are at the heart of the optoelectronic applications that have revolutionized our world for the last 70 years. Their hallmark characteristic is the existence of two electronic bands—the conduction and valence bands (CB and VB)—separated by a forbidden energy gap, which enables electrical and optical access to two distinct electronic populations. 3-band materials (3BM) represent a new class of semiconductor featuring three electronic bands and",{"id":884,"funder":7,"programme":8,"title":885,"piName":14,"institution":886,"country":21,"year":13,"amount":887,"abstract":888},"cordis-european-research-council-award-101228872","From biology to culture: Clarifying how humans categorize rhythm across the lifespan, senses, social learning and brain networks","UNIVERSITE CATHOLIQUE DE LOUVAIN","€1,999,300","Humans show an outstanding capacity to perceive and move to musical rhythms. These skills rely on mapping the sheer diversity of external rhythms onto a set of internal rhythm categories. However, the brain bases of rhythm categorization remain largely unknown. One view is that the underlying mechanisms are anchored in the evolutionarily oldest subcortical parts of the brain. This view is intuitive, given the universality of some musical rhythms (based on a grid of equal time intervals and their",{"id":890,"funder":7,"programme":8,"title":891,"piName":14,"institution":892,"country":628,"year":13,"amount":486,"abstract":893},"cordis-european-research-council-award-101231714","Exploring On-Chip Structured Illumination Microscopy Using Complex Patterns of Nanoscale Organic Light-Emitting Diodes","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","The Abbe diffraction of visible light underlies the spatial resolution in conventional optical microscopy, limiting the smallest dimension of Airy disk to approximately 250 nm. The invention and evolution of super-resolution (SR) fluorescence microscopy in the past three decades has showcased the ability to break the diffraction limit. Among all SR microscopy technologies, the structured illumination microscopy (SIM) represents one of the most popular methods to enable live-cell SR imaging at hi",{"id":895,"funder":7,"programme":8,"title":896,"piName":14,"institution":485,"country":73,"year":13,"amount":897,"abstract":898},"cordis-european-research-council-award-101231455","Nanomagnetic Tomography: Unlocking the Vortex Realm for Paleomagnetism and Rock-magnetism","€2,977,831","The Earth’s magnetic field plays a pivotal role in the Earth Sciences: magnetic signals stored in geological materials, such as igneous rocks, provide a record of Earth’s magnetic history and are essential for understanding e.g. tectonic processes, planetary dynamics, and the behavior of the geomagnetic field itself. Much of this record, however, remains inaccessible because not all magnetic particles in a sample reliably record the Earth’s magnetic field. Small, sub-micron vortex-state particle",{"id":900,"funder":7,"programme":8,"title":901,"piName":14,"institution":902,"country":903,"year":13,"amount":486,"abstract":904},"cordis-european-research-council-award-101169782","Single Polaron Tracking","UNIVERZITA KARLOVA","CZ","Polarons are quasiparticles that form in ionic lattices due to the coupling of excess electrons or holes with lattice vibrations. This leads to a spatial confinement of the charge carrier or even its complete localization, which presents a challenge for theoretical modelling. Polarons play a central role in many materials properties, such as electrical transport, optical properties, surface reactivity, or magnetoresistance, and are always investigated indirectly through such macroscopic characte",{"id":906,"funder":7,"programme":8,"title":907,"piName":14,"institution":908,"country":93,"year":13,"amount":486,"abstract":909},"cordis-european-research-council-award-101231244","Elucidating the Role of Subcellular GPCR Nanoswitches in Signaling Specificity","UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ","G protein-coupled receptors (GPCRs) relay extracellular information across the cell membrane to mediate most physiological cell functions. Many cell-surface GPCRs stimulate the production of cyclic adenosine monophosphate (cAMP), a diffusible second messenger, to elicit receptor-specific, long-range cell functions. However, given the mobility of second messengers, this canonical model fails to explain receptor-specific functions across multiple GPCRs that signal via cAMP. This application propos",{"id":911,"funder":7,"programme":8,"title":912,"piName":14,"institution":913,"country":93,"year":13,"amount":914,"abstract":915},"cordis-european-research-council-award-101229714","Constraints and Forces for p-Block Element Mediated Bond Activation and Catalysis","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","€2,802,181","Enabling p-block element species for challenging bond activations is crucial for advancing sustainable alternatives to transition metal catalysis. Even more transformative are concepts that guide reactivity in a generalizable manner and for cross-disciplinary impact. While sub-valent species or Frustrated Lewis pairs served as foundational paradigms for p-block-mediated bond activation in recent decades, the structural constraint strategy is emerging as a groundbreaking third approach. However, ",{"id":917,"funder":7,"programme":8,"title":918,"piName":14,"institution":919,"country":443,"year":13,"amount":920,"abstract":921},"cordis-european-research-council-award-101231627","Quantum Photonics in Space and Time","HERIOT-WATT UNIVERSITY","€2,976,710","The realization of complex quantum networks that efficiently distribute entanglement over large-scale distances remains a central challenge in quantum technologies, while offering the potential for breakthrough next-generation applications. Entanglement-based quantum communication can provide the ultimate form of security that is independent of any devices used, distributed quantum computing protocols promise a scalable approach to fault-tolerant quantum computing that will revolutionize informa",{"id":923,"funder":7,"programme":8,"title":924,"piName":14,"institution":925,"country":443,"year":13,"amount":926,"abstract":927},"cordis-european-research-council-award-101232407","Ångström-Scale channels for Sensing, Ionic devices, and Chemistry in confinement","THE UNIVERSITY OF MANCHESTER","€2,999,975","Angstrom-scale fluidic channels, constructed with atomic precision, present an extraordinary opportunity to manipulate and understand molecular transport, ionic interactions, and reactivity at dimensions where quantum and classical phenomena converge. This proposal pioneers the exploration of these channels as advanced platforms for investigating interplay of ionic dynamics, driving innovations in memory devices, neuromorphic computing, sensing, and chemistry, with implications for energy-effici",{"id":929,"funder":7,"programme":8,"title":930,"piName":14,"institution":566,"country":21,"year":13,"amount":931,"abstract":932},"cordis-european-research-council-award-101231235","Engineering thermal (in)stability in heteromagnetic nanostructures","€2,841,250","Beyond exchange bias systems, where antiferromagnetic layers stabilize ferromagnetic layers, antiferromagnets have seen limited practical use due to their zero net magnetic moment, which hinders both sensing and interaction with the magnetization. However, in comparison with ferromagnets, antiferromagnets intrinsically display orders of magnitude faster magnetization dynamics, making them highly attractive for technological applications.In most nanotechnological applications, flips of the magnet",{"id":934,"funder":7,"programme":8,"title":935,"piName":14,"institution":936,"country":937,"year":13,"amount":938,"abstract":939},"cordis-european-research-council-award-101231075","Microbial Photonics Across Scales","UNIVERSITE DU LUXEMBOURG","LU","€2,415,584","Phototrophic microorganisms including diverse bacteria harness sunlight to execute metabolic functions, rendering them indispensable as the base of most of the aquatic food webs. Harnessing light efficiently, a key prerequisite for survival and fitness of such species, is achieved biochemically via photoreceptors and light-sensitive actuators, cascading into gene expressions, protein functions, and tactic traits. Our recent findings on bacterial sulphur globules—energy-rich intracellular organel",{"id":941,"funder":7,"programme":8,"title":942,"piName":14,"institution":943,"country":73,"year":13,"amount":944,"abstract":945},"cordis-european-research-council-award-101231837","Redefining language as an emergent function of the connected brain","STICHTING RADBOUD UNIVERSITEIT","€1,998,348","The traditional view of language as relying on isolated brain areas is increasingly challenged by clinical and anatomical evidence suggesting that it emerges from the dynamic interplay of distributed neural networks across cortical, subcortical, and white matter systems. Despite language’s centrality to human cognition, a unified anatomical model integrating structural, functional, and neurochemical foundations remains absent—limiting progress in our fundamental understanding and clinical transl",{"id":947,"funder":7,"programme":8,"title":948,"piName":14,"institution":943,"country":73,"year":13,"amount":949,"abstract":950},"cordis-european-research-council-award-101229813","Precision cosmic-ray detection with the Square Kilometer Array","€3,000,000","What is the origin of the highest energy Galactic cosmic rays, ionized atomic nuclei that travel through space at nearly the speed of light? To answer this question we must detect them via the “air showers” of particles that are induced when cosmic rays interact in the atmosphere. Current experiments lack the precision needed to fully reconstruct air shower features and, consequently, to understand the cosmic rays themselves. Moreover, the hadronic interactions that shape air shower development ",{"id":952,"funder":7,"programme":8,"title":953,"piName":14,"institution":954,"country":87,"year":13,"amount":486,"abstract":955},"cordis-european-research-council-award-101230403","Molecular mechanisms orchestrating  the lifecycle of human tRNAs","MEDIZINISCHE UNIVERSITAET WIEN","By delivering amino acids to translating ribosomes, transfer RNAs (tRNAs) are central to protein synthesis. These small (~76 nucleotide-long) molecules have very similar three-dimensional structures, which must withstand substantial conformational changes throughout the tRNA lifecycle. To meet these demands, tRNAs are decorated by diverse chemical modifications at multiple nucleotides by highly conserved enzymes. Defects in the genes encoding these enzymes are linked to neurodevelopmental disord",{"id":957,"funder":7,"programme":8,"title":958,"piName":14,"institution":746,"country":80,"year":13,"amount":959,"abstract":960},"cordis-european-research-council-award-101232064","Rethinking the Welfare State under Political Constraints in a Changing World","€1,277,425","Initially intended to shield individuals from adverse macroeconomic shocks, welfare programs such as social security have grown significantly over time, evolving into politically entrenched entitlements. Demographic changes, including declining fertility rates and increasing life expectancy, have further fueled their expansion, raising fiscal pressure. While retrenchment reforms are recognized as essential for economic sustainability, strong public support for welfare programs often renders them",{"id":962,"funder":7,"programme":8,"title":963,"piName":14,"institution":964,"country":87,"year":13,"amount":965,"abstract":966},"cordis-european-research-council-award-101230969","Precision measurements of parity violation using trapped neutral molecules","TECHNISCHE UNIVERSITAET WIEN","€1,999,728","One of the main driving forces of physics is the search for the most fundamental laws of nature. In PRIME-MOL, I will expand our understanding of these fundamental laws by trapping laser-cooled molecules and using them as precision sensors.Molecules have become pivotal tools in precision measurement science, offering exceptional opportunities for advanced spectroscopy and tests of fundamental symmetries. This can provide unique insights that complement those from experiments at large collider fa",{"id":968,"funder":7,"programme":8,"title":969,"piName":14,"institution":970,"country":443,"year":13,"amount":971,"abstract":972},"cordis-european-research-council-award-101171076","Losing genes but gaining symbionts: Why beetles outsource key metabolic traits","JOHN INNES CENTRE","€1,999,758","Herbivorous beetles represent one of the most successful animal radiations. The cooption of microbial enzymes is cited as a key innovation that endowed beetles with the catalytic tools to breach the plant cell wall and facilitated the evolution of remarkably diverse herbivorous habits. Beetles incorporated microbial plant cell wall-degrading enzymes either through horizontal gene transfer or symbiosis. This binary distribution is most evident in leaf beetles (Coleoptera: Chrysomelidae), where th",{"id":974,"funder":7,"programme":8,"title":975,"piName":14,"institution":976,"country":93,"year":13,"amount":977,"abstract":978},"cordis-european-research-council-award-101230161","Conserved Environmental Programs of Streptophyte Cells","GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS","€1,997,079","A single monophylum accounts for our entire macroflora: the embryophytes, thus referred to as land plants. Emerging from streptophyte algae, the embryophyte lineage successfully established itself and massively radiated on land. What allowed for this singular success story? One of the features strictly required and particularly prominent in land plants is the ability to adjust their growth and physiology according to environmental cues specifically encountered in terrestrial habitats. Land plant",{"id":980,"funder":7,"programme":8,"title":981,"piName":14,"institution":602,"country":603,"year":13,"amount":982,"abstract":983},"cordis-european-research-council-award-101231600","Two sides to every leaf: how and why plants control stomatal distribution between leaf surfaces?","€1,999,625","Plant leaves are polar organs with different upper (adaxial) and lower (abaxial) surfaces. Stomata are adjustable pores in leaves that allow CO2 influx for photosynthesis and mediate water loss via transpiration. These key structures that control plant survival and productivity are polarly localised only in leaf abaxial epidermis in most plants (hypostomaty). Some plants have stomata also on the upper leaf side; such amphistomatous plants should have a fitness advantage due to a better photosynt",{"id":985,"funder":7,"programme":8,"title":986,"piName":14,"institution":860,"country":73,"year":13,"amount":987,"abstract":988},"cordis-european-research-council-award-101231593","EXoplanet SpectrosCopy using 0-nOise Photon Energy resolving Detectors","€2,882,225","The question: ‘are we alone in the universe?’, is a central question in astronomy. It has become even more relevant due to the discovery of exoplanets within the habitable zone around their star. The presence of life could be determined from biomarkers in the spectrum of a planet’s atmosphere. However, an Earth-like planet around a Sun-like star is very faint, after suppressing the starlight. A crucial technology is therefore a noiseless, photon-counting detector, which resolves the energy of ea",{"id":990,"funder":7,"programme":8,"title":991,"piName":14,"institution":992,"country":93,"year":13,"amount":993,"abstract":994},"cordis-european-research-council-award-101231554","Artificial Cellulose Synthesizing Machinery  for Bottom-up Nanocellulose Manufacturing","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€1,997,765","Cellulose, the most abundant and renewable biopolymer on Earth, plays a critical role in numerous industries, from textiles and packaging to construction and electronics. Its exceptional mechanical strength, stability, and renewability make it a versatile material with immense potential for driving sustainable innovations. These remarkable properties are rooted in the unique hierarchical structure of cellulose and the crystalline nature of its nanofibers, termed cellulose microfibrils. Despite i",{"id":996,"funder":7,"programme":8,"title":997,"piName":14,"institution":998,"country":314,"year":13,"amount":999,"abstract":1000},"cordis-european-research-council-award-101231611","Protectionism in Place: Explaining How Subnational Change Affects Public Support for Protectionism","STOCKHOLMS UNIVERSITET","€1,995,155","After a period of hyperglobalization, protectionist policies have become more entrenched over the past decade. States have produced a slew of domestic subsidies, tariffs, and labor migration policies––policies that can benefit certain industries, but are likely to curtail growth, employment, and multilateral economic cooperation. Why citizens support protectionism that is costly to them is a central puzzle in International Political Economy public opinion research.Although no consensus has been ",{"id":1002,"funder":7,"programme":8,"title":1003,"piName":14,"institution":1004,"country":443,"year":13,"amount":1005,"abstract":1006},"cordis-european-research-council-award-101230002","Advanced Techniques in Light and Acoustic Near-fields: Time and Spatial structuring","KING'S COLLEGE LONDON","€1,997,717","Optical and acoustic near-fields offer immense untapped potential for breakthroughs in metrology, imaging, nanorouting, sensing, contactless manipulation, and information technologies. ATLANTIS aims to uncover fundamental physical principles and novel applications in optical and acoustic near-fields, while advancing our understanding of wave behaviour at subwavelength scales.Far-field breakthroughs have emerged from challenging traditional assumptions, such as time-harmonicity, single wavevector",{"id":1008,"funder":7,"programme":8,"title":1009,"piName":14,"institution":1010,"country":443,"year":13,"amount":1011,"abstract":1012},"cordis-european-research-council-award-101232252","Defining Region-Specific Microglia Endolysosomal Dysfunction and Neuro-Immune Crosstalk in Aging and Neurodegeneration","UNIVERSITY COLLEGE LONDON","€1,999,999","Microglia, the brain’s primary macrophages, play essential role in preserving neuronal homeostasis, clearing debris and shaping neural circuits throughout life. These functions are pivotal, particularly in context of aging and neurodegenerative diseases. Human genetic studies implicate microglia in age-related neurodegenerative diseases, with alterations in their endolysosomal network emerging as a critical determinant of disease risk. However, how microglial endolysosomal functions alter during",{"id":1014,"funder":7,"programme":8,"title":1015,"piName":14,"institution":627,"country":628,"year":13,"amount":1016,"abstract":1017},"cordis-european-research-council-award-101229500","Non-Utilitarian Perspectives on Population Policy","€1,993,568","The world is undergoing a dramatic demographic transition. Fertility rates are falling almost everywhere. In many countries, birth rates are already below replacement. How should policymakers respond, if at all?This question poses a unique challenge because, in addition to standard utilitarian considerations, there are important non-utilitarian angles to consider. The goal of this project is to surface these considerations and clarify their implications for optimal fertility policy.This project ",{"id":1019,"funder":7,"programme":8,"title":1020,"piName":14,"institution":621,"country":93,"year":13,"amount":1021,"abstract":1022},"cordis-european-research-council-award-101231469","Carbides to Molecules","€1,999,725","Disubstituted carbon species, specifically carbenes (“CR2”) and their metal complexes, drive innovation across synthesis, catalysis, materials science, and medicine. In stark contrast, the corresponding carbynes (“CR”) and carbides (“C”) remain curiosity compounds or elusive entities. In fact, C1, C3 and to some extent C2 transfer generally remains a pressing challenge in the molecular sciences, while the controlled synthesis of carbon allotropes represents a millenial challenge.  CARB2MOL seeks",{"id":1024,"funder":7,"programme":8,"title":1025,"piName":14,"institution":1026,"country":443,"year":13,"amount":1027,"abstract":1028},"cordis-european-research-council-award-101230673","Representations of Cognitive Geography for Navigating Sustainable Neighbourhoods","UNIVERSITY OF LEEDS","€1,999,465","At the heart of quantitative geographic analysis exists a critical disconnect. Digital representations of space, upon which all spatial data are based, do not reflect how geographic spaces are remembered by people. This fundamental issue of spatial representation has profound implications for how we analyse, model, and ultimately, design our cities and societies. If we fail to accurately represent cities as people see them, how can we expect our computational methods to accurately understand the",{"id":1030,"funder":7,"programme":8,"title":1031,"piName":14,"institution":1010,"country":443,"year":13,"amount":1032,"abstract":1033},"cordis-european-research-council-award-101231663","Good Jobs Economics: Incentives and Policies","€1,988,201","Many advanced economies report low unemployment and tight labour markets yet continue to grapple with economic inequality and a scarcity of good jobs. A sizable share of workers remains stuck in low-paying positions with limited chances for career advancement. This research program examines multiple dimensions of good job creation, from the implications of part-time work to the influence of labour market institutions such as the minimum wage. It analyses whether workers fully account for the lon",{"id":1035,"funder":7,"programme":8,"title":1036,"piName":14,"institution":943,"country":73,"year":13,"amount":1037,"abstract":1038},"cordis-european-research-council-award-101230942","Reconstructing medieval minority ritual practice in Islamic Spain, 711-1400","€1,999,710","Ritual is a powerful means for minority religious communities to express and preserve their collective identities. This has traditionally been said of Christians in al-Andalus, the area of the Iberian Peninsula that was under Islamic rule for half a millennium in the middle ages. The idea that minority Christians in this area continued to practice the same religious rites as before the Arab conquest is thought to show their resistance to Islamic rule. But can we assume this without establishing ",{"id":1040,"funder":7,"programme":8,"title":1041,"piName":14,"institution":1042,"country":443,"year":13,"amount":1043,"abstract":1044},"cordis-european-research-council-award-101229684","Unravelling the genetic codes governing transposon mobilization","UNIVERSITY OF DURHAM","€1,983,933","Transposons are ubiquitous DNAs capable of changing their genomic locations. While historically perceived as detrimental and damaging to host genomes, they have also been a major source of genetic variability, driving evolution. Unfortunately, the regulatory mechanisms of transposons remain largely unknown, primarily due to the lack of experimental methods to trace their movement. This project therefore aims to dissect the regulation of transposons in plants with unprecedented detail. This goal ",{"id":1046,"funder":7,"programme":8,"title":1047,"piName":14,"institution":596,"country":443,"year":13,"amount":1048,"abstract":1049},"cordis-european-research-council-award-101231459","Cancer-Osteocyte NeTwoRk Atlas","€1,999,186","Metastatic breast cancer claims the lives of more European women than any other cancer, and is an ever-growing problem in an aging global population that increasingly survives treatment of primary cancer. The most common site for metastatic breast lesions is bone, with 75% of patients experiencing pathological fractures, spinal cord compression or severe bone pain. Crosstalk between cancer cells and osteocytes, which make up more than 90% of our bone cells and form a complex sensing and signalli",{"id":1051,"funder":7,"programme":8,"title":1052,"piName":14,"institution":892,"country":628,"year":13,"amount":1053,"abstract":1054},"cordis-european-research-council-award-101231981","Unraveling the Life Cycle of Metastatic Cells from Invasion to Outgrowth.","€2,535,325","Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide, accounting fornearly 10% of cancer-related deaths. The majority of CRC-related deaths result from metastaticdissemination, with the liver and lung being the most frequent distant sites of metastasis. Effective therapiesto prevent metastatic CRC progression are lacking. This gap stems from our limited understanding of thecancer-intrinsic and tumor microenvironmental factors that drive advancement through ea",{"id":1056,"funder":7,"programme":8,"title":1057,"piName":14,"institution":1058,"country":443,"year":13,"amount":1059,"abstract":1060},"cordis-european-research-council-award-101230808","Scientific Progress and Artificial Intelligence: a Capabilities-Based Ethnographic Epistemology","UNIVERSITY OF YORK","€1,935,827","Science is famous for its tools, which focus or empower abilities like seeing, calculating, remembering, manipulating, and predicting. Yet despite centuries of organized science and decades of science studies, there is still very little written about what scientific abilities are, or how tools extend them. This is striking, because scientific progress is clearly tied to scientists' increasing ability to solve problems. PACE proposes an interdisciplinary comparative study of what is being called ",{"id":1062,"funder":7,"programme":8,"title":1063,"piName":14,"institution":774,"country":93,"year":13,"amount":1064,"abstract":1065},"cordis-european-research-council-award-101231434","Unlocking the tissue code: Understanding organ-specific regulation of CD8+ T cell immunity by eicosanoids","€1,986,850","CD8+ T cells are critical for immunity against infection and cancer. Eliciting protective CD8+ T cell immunity is the main goal of many current and emerging immunotherapies aimed at treating these diseases, holding the promise to substantially improve patient outcomes. Evidence suggests that T cell regulation by tissue-derived factors is one of the key mechanisms influencing the protective potential of CD8+ T cell responses, however, the nature and molecular impact of these factors remains incom",{"id":1067,"funder":7,"programme":8,"title":1068,"piName":14,"institution":566,"country":21,"year":13,"amount":1069,"abstract":1070},"cordis-european-research-council-award-101230424","Advancing NANOmedicines to rewire tumoral MYeloid cells for next-generation cancer immunotherapies","€2,499,750","Persistent inflammation during tumorigenesis drives myelopoiesis. Consequently, monocytes and granulocytes\u002Fneutrophils infiltrate the tumor microenvironment (TME) and differentiate into tumor-associated macrophages or myeloid-derived suppressor cells, creating an immune-suppressive microenvironment that hampers cytotoxic T cell function and limits immune checkpoint inhibitor (ICI) efficacy. ‘Reprogramming’ myeloid cells to adopt pro-inflammatory phenotypes is promising to restore immune function",{"id":1072,"funder":7,"programme":8,"title":1073,"piName":14,"institution":596,"country":443,"year":13,"amount":1074,"abstract":1075},"cordis-european-research-council-award-101231435","Mechanisms of Multimorbidity – from Populations to Cells","€1,999,722","The overarching goal of my proposal is to deliver multimorbidity research that challenges and re-designs current thinking by combining agnostic, i.e. hypothesis-free discovery approaches with targeted hypothesis testing, bespoke experimental follow-up and validation. My proposal is to consider and integrate data across all diseases in diverse populations and at different life stages with focused clinical challenges and in-depth molecular investigations. By building and leading a team that delive",{"id":1077,"funder":7,"programme":8,"title":1078,"piName":14,"institution":455,"country":443,"year":13,"amount":1079,"abstract":1080},"cordis-european-research-council-award-101231154","Bridging Rural-urban Individual Divides in Outlooks and Political Engagement","€1,999,776","Polarisation between urban and rural areas is a key societal cleavage. Existing research finds that rural populations often hold more conservative views, while urban residents are generally associated with progressive positions on issues such as immigration, cosmopolitanism, gender equality, and LGBTQ+ rights. Urban populations are also more likely to acknowledge anthropogenic climate change and support decarbonisation policies. However, critical questions about the causes and consequences of th",{"id":1082,"funder":7,"programme":8,"title":1083,"piName":14,"institution":1084,"country":374,"year":13,"amount":982,"abstract":1085},"cordis-european-research-council-award-101230040","Recoding Criminal Justice in the Age of Generative AI Disruption","UNIVERSITY OF HAIFA","How will Generative AI (GenAI) reshape criminal justice? Unlike earlier AI systems, often confined to specific tasks and users, GenAI democratizes and boosts AI’s capabilities, transforming our understanding of AI’s role in justice systems. GenAI enables wider access—for police officers, investigators, lawyers, judges, prison staff, and rehabilitation workers—and diverse applications, from aiding in crime analysis and drafting legal arguments to generating personalized rehabilitation plans, span",{"id":1087,"funder":7,"programme":8,"title":1088,"piName":14,"institution":1089,"country":27,"year":13,"amount":982,"abstract":1090},"cordis-european-research-council-award-101231604","Helico-Selective Membrane Transport","UNIVERSIDAD DE SANTIAGO DE COMPOSTELA","Membrane transport regulation is a sophisticated process only achieved by complex pore-forming membrane proteins. Controlling the transportation of bioactive molecules with high selectivity can pioneer a paradigm shift in the precision of membrane-related applications (e.g., drug and gene delivery, biosensing, signaling, metabolic activity manipulation, etc.).Despite the research effort in membrane transport and significant advances in membrane pore engineering, a critical knowledge gap still hi",{"id":1092,"funder":7,"programme":8,"title":1093,"piName":14,"institution":1094,"country":374,"year":13,"amount":1095,"abstract":1096},"cordis-european-research-council-award-101231672","Systematic Investigation of Anti-Defense Function and Regulation in Bacterial Conjugation","TEL AVIV UNIVERSITY","€2,275,000","The microbial world's genomic arms race spurred a remarkable diversity of defense and anti-defense mechanisms, with CRISPR-Cas and anti-CRISPR systems as prime examples that revolutionized genome editing. Recent years have seen a surge in the discovery of bacterial anti-phage systems and their viral countermeasures, yet little is known about how plasmids—key vectors of antibiotic resistance—overcome host defenses. Our lab recently found that plasmids' leading regions, the first to enter recipien",{"id":1098,"funder":7,"programme":8,"title":1099,"piName":14,"institution":1100,"country":1101,"year":13,"amount":1102,"abstract":1103},"cordis-european-research-council-award-101231110","Countering Insurgency\u002FTerrorism: Severing the Ties between Non-State Armed Actors & Their Constituency","BILKENT UNIVERSITESI VAKIF","TR","€1,989,930","COUNSTER introduces a novel triadic framework to investigate government strategies for combatting radicalization, insurgency, and terrorism by focusing on the role non-state armed actors’ (NSAAs) constituents play in conflict processes. While the literature extensively addresses military aspects of conflicts, how governments strategically engage with NSAAs’ constituents during a conflict to sever the ties between the two (hereafter referred to as to counster \u002F counstering, a term coined within t",{"id":1105,"funder":7,"programme":8,"title":1106,"piName":14,"institution":1107,"country":628,"year":13,"amount":486,"abstract":1108},"cordis-european-research-council-award-101230593","Planetary Systems from Interstellar Ingredients","UNIVERSITAET BERN","Every year, more and more different types of complex organic molecules are discovered in infant star-forming regions. In my series of works, I demonstrated that the molecules found towards Sun-like protostars are qualitatively related to those found in comets in our Solar System. The outstanding challenge is that we do not know if these molecules have been inherited, or destroyed and reformed. However, the journey of material from prestellar cores and protostars to protoplanetary disks and plane",{"id":1110,"funder":7,"programme":8,"title":1111,"piName":14,"institution":1112,"country":12,"year":13,"amount":1113,"abstract":1114},"cordis-european-research-council-award-101229856","A Computational Theory of Rhythmic Attentional Sampling Functions","UNIVERSITE PARIS CITE","€1,998,820","For every action, we see, hear, touch, smell and taste our surroundings. Our senses constantly receive a seemingly unmanageable flow of sensory signals. Attention is the mental function that selects relevant sensory information and ameliorate their processing by the brain to efficiently guide our actions.The recent years witnessed a paradigm shift in the field of attention research. Opposite to our impression that one can deploy attention continuously over short time periods, attention in fact p",{"id":1116,"funder":7,"programme":8,"title":1117,"piName":14,"institution":1094,"country":374,"year":13,"amount":1118,"abstract":1119},"cordis-european-research-council-award-101232065","Social Inequalities in Bereavement: From Demographic Rates to Lived Experience","€1,960,000","Due to the rise in human longevity, many individuals in low-mortality countries can now expect to grow old, to be survived by their children, and to know their grandchildren. Yet, these prospects are not equally shared. Social inequalities in mortality persist and may lead to inequalities in family bereavement. How exposure to bereavement is internalized by individuals and shapes their lives is a key sociological question, with the potential to establish a new research program at the intersectio",{"id":1121,"funder":7,"programme":8,"title":1122,"piName":14,"institution":869,"country":73,"year":13,"amount":486,"abstract":1123},"cordis-european-research-council-award-101230415","Parenting in Times of Global Uncertainty: Understanding and Cultivating Parental Hope","Today’s parents raise their children in times of environmental and geopolitical crises. Current scientific frameworks fall short in understanding and supporting parenting in times of such uncertainty. They are predominantly based on deficit models of adversity and fail to explain why many parents defy what can be predicted from these models.PARENTALHOPE proposes a new model for understanding parenting in times of uncertainty. Building on insights from across the behavioural sciences on parents w",{"id":1125,"funder":7,"programme":8,"title":1126,"piName":14,"institution":1127,"country":443,"year":13,"amount":1128,"abstract":1129},"cordis-european-research-council-award-101229160","Single or Double? A Radical Approach to Main Group Catalysis","CARDIFF UNIVERSITY","€1,998,761","Can the use of d-block elements be circumvented in catalysis?The knowledge base of chemical transformations involving transition metal species is vast. Indeed, the versatility of transition metals has rendered them indispensable for a substantial number of transformations. Yet, the corresponding reactivity of compounds derived from the p-block elements is much less studied. However, in the last two decades, a number of advancements has inspired a renaissance in the chemistry of the p-block parti",{"id":1131,"funder":7,"programme":8,"title":1132,"piName":14,"institution":1133,"country":93,"year":13,"amount":1134,"abstract":1135},"cordis-european-research-council-award-101229569","Statistical Optimality and Computational Efficiency: batch and sequential unsupervised learning under additional structure and sampling constraints","UNIVERSITAET POTSDAM","€1,979,797","Unsupervised learning is a key problem of artificial intelligence, at the crossroad of statistics and machine learning. The aim is to infer patterns from unlabelled data, by providing learning algorithms that are computationally efficient - i.e. polynomial time - and statistically performant - i.e. minimising an error criterion - and by characterising the fundamental limits for learning.In the last decade, deep and important phenomena of statistical-computational trade-offs have been unveiled: f",{"id":1137,"funder":7,"programme":8,"title":1138,"piName":14,"institution":1139,"country":781,"year":13,"amount":1140,"abstract":1141},"cordis-european-research-council-award-101230897","Small Differences, Big Impact: Achieving Effective Selective Separations from Water by Tuning Ion Transport Processes","POLITECHNIKA WROCLAWSKA","€1,993,767","Selective ion separation plays a crucial role in Selective ion separation plays an important role in water treatment, resource recovery, and agriculture. As the need for sustainable water use intensifies and global demand for strategic resources like lithium increases, developing efficient and selective ion separation technologies becomes essential. In particular, the selective separation of ions with similar properties, such as sodium (Na+) and potassium (K+), remains a significant challenge.In",{"id":1143,"funder":7,"programme":8,"title":1144,"piName":14,"institution":925,"country":443,"year":13,"amount":1145,"abstract":1146},"cordis-european-research-council-award-101230168","New physics from a precision concordance model of the radio sky","€2,250,330","My proposal is to build an unprecedentedly accurate and complete model of the radio sky, and then use it to solve several important problems in astrophysics and cosmology. The model will incorporate improved analyses of existing data, plus new, precisely-calibrated observations from a novel horn antenna telescope that I will build. Using advanced statistical techniques capable of handling millions of parameters – implemented in my world-leading Hydra code – I will disentangle the many physical c",{"id":1148,"funder":7,"programme":8,"title":1149,"piName":14,"institution":809,"country":628,"year":13,"amount":1150,"abstract":1151},"cordis-european-research-council-award-101231026","Evolution of Mechanisms for Sex Chromosome Dosage Compensation and Gene Regulation","€1,999,177","There is a remarkable diversity of phenotypes among multicellular animals, including differences between males and females. A major driver of phenotypic variation stems from differences in gene regulation. The evolution of these regulatory mechanisms is a central, yet unresolved question in biology. Sex chromosome dosage compensation (SCDC) is an epigenetic process that equalizes sex chromosomal gene expression between males and females. 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