[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-proof-of-concept-2015":3,"awarded-stats-erc-proof-of-concept":750},{"awarded":4,"total":749},[5,16,21,28,35,40,45,49,54,61,68,73,78,84,90,94,100,104,108,113,117,123,129,134,139,144,150,157,163,169,176,180,186,192,198,203,208,214,219,225,230,235,241,247,253,257,263,269,275,280,285,290,295,300,306,311,316,322,328,334,339,344,348,354,360,364,369,374,379,384,389,395,400,404,411,415,421,426,431,435,441,446,451,456,461,466,471,475,479,484,489,495,500,506,512,517,521,527,532,536,540,545,549,553,557,562,568,573,579,585,589,595,601,606,610,614,620,625,631,636,640,646,651,655,661,666,672,678,682,688,693,698,703,709,713,717,722,728,733,737,741,745],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-680894","European Research Council","ERC Proof of Concept","Wide Spectral Range Photonic Glucometer",null,"AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","ES",2015,"€149,972","Diabetic patients (around 8.6% of the western population) must constantly monitor their blood glucose level (BGL) with a continuous glucose monitoring (CGM) device. This social need has already been addressed by some companies, with an overall compound annual growth rate (CAGR) for this market (from 2014 through 2019) of 19.6%. Besides such highly attractive market possibilities, to date none of the commercial CGMs can provide accuracy below 20%. This is a non-assumable risk for the users. In ad",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":11,"country":12,"year":13,"amount":19,"abstract":20},"cordis-european-research-council-award-679942","Spatially Multiplexed Spectrophotometry","€149,922","As a result of the research undertaken in the NANOFORCELLS project (ERC-StG-2011-278860), Dr Montserrat Calleja’s team has successfully developed instrumentation for the investigation of cell mechanics. The NANOFORCELLS project proposes a tool-box of three converging technologies for the aim of discriminating cancer and healthy cells from their physical properties: AFM, label-free microscopy and nanomechanical sensors. The instrument object of commercialization through the FAST-SPECTRO project i",{"id":22,"funder":7,"programme":8,"title":23,"piName":10,"institution":24,"country":25,"year":13,"amount":26,"abstract":27},"cordis-european-research-council-award-665275","Tracing tropical timber","WAGENINGEN UNIVERSITY","NL","€148,387","An estimated 50% of the tropical timber that enters the European market is illegally harvested. To implement new European legislation intended to eliminate this illegal trade, independent tools will be needed to verify the legal status of timber. We therefore propose to develop a fast, accurate and cost-effective commercial forensic tool, 'Timtrace', for tracing the claimed origin of tropical timber. Timtrace uses (1) ring-width measurements that can be matched with reference measurements or cli",{"id":29,"funder":7,"programme":8,"title":30,"piName":10,"institution":31,"country":32,"year":13,"amount":33,"abstract":34},"cordis-european-research-council-award-680916","HYPHEN: Hybrid Photonic Engines for Massive Cloud Connectivity","KARLSRUHER INSTITUT FUER TECHNOLOGIE","DE","€149,875","The global explosion of data traffic and the migration of essential services to “the cloud” are combining to push current data-center infrastructures to their limits. This applies in particular to communication networks within and between data centers (DC), which limit scalability of computing and storage already today. Wavelength-division multiplexing (WDM) transmission schemes are key to overcome these bottlenecks, increasing the throughput of inter-DC and intra-DC communication links by more ",{"id":36,"funder":7,"programme":8,"title":37,"piName":10,"institution":31,"country":32,"year":13,"amount":38,"abstract":39},"cordis-european-research-council-award-680895","Magic angle coil spinning NMR on living voxels - LiVoX","€150,000","LiVoX will make our NMR microchip sensor market-ready for novel applications such as foodstuff testing, compound screening for example on cell-based assays, or biopsy monitoring for hospitals. By turning NMR sensors into consumables, LiVoX will achieve a paradigm shift that will open up these new markets.We are convinced that the sensors will be readily accepted by the market, since they already work with established and installed NMR hardware, and provide dramatically increased NMR measurement ",{"id":41,"funder":7,"programme":8,"title":42,"piName":10,"institution":31,"country":32,"year":13,"amount":43,"abstract":44},"cordis-european-research-council-award-680375","Peptide arrays as a high throughput pre-screening tool","€147,247","Funded by the ERC-Starting Grant COMBIPATTERNING, we have conducted proof-of-principle experiments to synthesize peptide arrays with a density of up 25 Mio spots per cm2 (2 µm pitch). With these spot densities, a microscope slide would display more than a Billion different peptide spots, which is comparable to phage display technologies. Therefore, we want to verify the innovation potential of our novel very-high-density peptide arrays that should find a market in all kinds of applications where",{"id":46,"funder":7,"programme":8,"title":47,"piName":10,"institution":31,"country":32,"year":13,"amount":38,"abstract":48},"cordis-european-research-council-award-680913","All-in-One Cell Screening Chip: Device for Affordable High-Throughput Cell Screenings","Experiments with live cells are fundamentally important in biology, pharmaceutical industry, biotechnology or in medicine and diagnostics. One important example of cell experiments is the prescreening of cells from cancer biopsies with anticancer drugs in order to identify the most effective and least toxic combination of drugs for a particular patient also known as personalized medicine.The goal of this ERC Proof-of-Concept project is to develop, fabricate and optimize a device (CellScreenChip)",{"id":50,"funder":7,"programme":8,"title":51,"piName":10,"institution":52,"country":12,"year":13,"amount":38,"abstract":53},"cordis-european-research-council-award-680608","Culture Aware Music Technologies","UNIVERSIDAD POMPEU FABRA","The gap between the current capabilities of the music technologies used in commercial services and the needs of our culturally diverse world is still immense, e.g. in the several music traditions of culturally rich and diverse India. The existing technologies fall short of utilizing even the basic musical characteristics and hence they limit our music listening experience. The consumption practices of services and products for Indian music vary to a large extent from those of other popular music",{"id":55,"funder":7,"programme":8,"title":56,"piName":10,"institution":57,"country":58,"year":13,"amount":59,"abstract":60},"cordis-european-research-council-award-680897","Product identification using sequence-controlled oligomers","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","FR","€149,784","The aim of the project Sequence Barcodes will be to study the market potential of sequence-encoded oligomers developed and patented in the frame of the ERC starting grant project SEQUENCES (grant agreement n°258593, End-date: October 2014). In particular, we propose to use monodisperse oligomers with defined chain-lengths and monomer sequences as molecular barcodes for product identification. A code can be written in the oligomers using different monomers as an alphabet, for example using two (i",{"id":62,"funder":7,"programme":8,"title":63,"piName":10,"institution":64,"country":65,"year":13,"amount":66,"abstract":67},"cordis-european-research-council-award-641211","Development of a new plant variety for the Asian market","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","UK","€148,307","Palms are some of the most successfully traded plants, with numerous species sold for indoor, outdoors and as crops. The kentia palm (Howea forsteriana), is one of the most widely exported houseplants in the world and is worth over seven million euros per year in the Dutch horticultural industry alone. Wild kentias are only found on a 12km2 island in the middle of the Tasman Sea, Lord Howe Island (LHI). LHI is a unique ecosystem. It is the focus of the applicant's ERC Advanced Grant, who is usin",{"id":69,"funder":7,"programme":8,"title":70,"piName":10,"institution":64,"country":65,"year":13,"amount":71,"abstract":72},"cordis-european-research-council-award-692939","Anti-reflection coatings from solution-processable, high-refractive index inorganic\u002Forganic hybrid materials","€146,929","COAT activities aim at developing a new generation of anti-reflection (AR) coatings based on the inorganic\u002Forganic hybrid materials advanced in OASIS (Project No: 279587). COAT provides the necessary manpower for screening new formulations and produce large-area demonstrators and illustrative prototypes to persuade major partner of the validity of the proposed technology approach for future commercialisation. To ensure these demonstrators fulfil the needs of coating manufacturers and end-users, ",{"id":74,"funder":7,"programme":8,"title":75,"piName":10,"institution":76,"country":32,"year":13,"amount":38,"abstract":77},"cordis-european-research-council-award-680902","Robotic manipulator with visuo-haptic sensing","TECHNISCHE UNIVERSITAET MUENCHEN","This proof-of-concept project aims to develop and bring to market a novel visuo-haptic sensor system for robotic manipulators, which allows for multimodal sensing, reduced system complexity and significantly lower costs compared to current systems. It replaces dedicated force sensors with passive components and a camera, providing coherent measurements of both force and contact shape. Three sensor setups for grippers, mobile platforms and tools on the endeffector have already been implemented as",{"id":79,"funder":7,"programme":8,"title":80,"piName":10,"institution":81,"country":82,"year":13,"amount":38,"abstract":83},"cordis-european-research-council-award-664782","Versatile optomechANical GRaphene Device for bio-tissue engineering","CONSIGLIO NAZIONALE DELLE RICERCHE","IT","Tissue and organ failure, caused by injury or other type of damage, accounts for a large part of the health care costs in EU and U.S. Current surgical or grafting procedures are only partly successful in restoring the functions of the damaged tissues.Tissue Engineering has emerged as a rapidly expanding field for repair and regeneration of damaged tissue and organs.This involves the seeding and attachment of human cells onto a scaffold through in-vitro, or a combination of in-vitro and in-vivo. ",{"id":85,"funder":7,"programme":8,"title":86,"piName":10,"institution":87,"country":58,"year":13,"amount":88,"abstract":89},"cordis-european-research-council-award-665113","An innovative tool for non-invasive evaluation of myocardial stiffness","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","€149,750","Heart failure (HF) affects 14 million people in Europe, and this number is expected to increase to 30 million by 2020. Early diagnosis of HF is essential for successfully addressing underlying causes. However, initial diagnosis is difficult in many situations so that HF is correctly diagnosed in only half of patients. Diastolic HF, that accounts for more than 50% of all HF patients, is due to abnormal ventricular stiffness which remains very difficult to diagnose. The characterization of myocard",{"id":91,"funder":7,"programme":8,"title":92,"piName":10,"institution":87,"country":58,"year":13,"amount":38,"abstract":93},"cordis-european-research-council-award-640923","Development of pregnenolone derivatives as allosteric inhibitors of CB1 cannabinoid receptors for the treatment of schizophrenia and psychotic syndromes","Excessive activation of the cannabinoid type-1 receptor (CB1) in the brain by synthetic, endogenous or plant-derived(cannabis sativa) cannabinoids can lead to pathological states, which could be ameliorated by blocking receptor signalling.However, due to the large number of functions involving the CB1 receptor, direct CB1 antagonist drugs induce side effectslimiting their therapeutic use. During the ERC-StG funded project, we found that a particular endogenous and labile lipidcompound, pregnenol",{"id":95,"funder":7,"programme":8,"title":96,"piName":10,"institution":97,"country":58,"year":13,"amount":98,"abstract":99},"cordis-european-research-council-award-641187","Flow Machines","SORBONNE UNIVERSITE","€145,500","The music industry has seen its profits decrease drastically since 2000, challenged by other forms of entertainment such as video games and the internet, as well as by illegal download and piracy. However, there is a growing activity in the so-called music synchronization business: music composed, retrieved, or otherwise produced to fit with the many constraints of videos, movies, games or commercials. Synchronized music has to satisfy complex constraints, specified temporally (specific events a",{"id":101,"funder":7,"programme":8,"title":102,"piName":10,"institution":97,"country":58,"year":13,"amount":38,"abstract":103},"cordis-european-research-council-award-665595","Optimal Person-Machine Sensorimotor Coupler for Application to Micro-Manufacturing","Micro-manufacturing is a key sector for the EU industry. Enabling flexible, cost efficient, and compact production is essential to gain competitive edge and leadership in the manufacturing of high value-added miniatur- ized products. The manual, high-precision assembly or manipulation of micro-parts required for miniaturized assemblies is required by several markets. Companies using micro-mechanical processes, such in horology, or miniature devices employed in the aerospace and defense industrie",{"id":105,"funder":7,"programme":8,"title":106,"piName":10,"institution":11,"country":12,"year":13,"amount":10,"abstract":107},"cordis-european-research-council-award-664714","Fast Data Acquisition and Servo Technologies","Fast data acquisition devices and servo technologies are essential in multiple processes that require a fast response to a sensor input. They are present in multiple automatic procedures for the accurate functioning of trains, planes, and robotic systems either for domestic or industrial activities. As a result of the research performed in the SM-DNA-Repair project (ERC-206117), we have developed a fully digital acquisition board superior in most specifications to current technology because it c",{"id":109,"funder":7,"programme":8,"title":110,"piName":10,"institution":11,"country":12,"year":13,"amount":111,"abstract":112},"cordis-european-research-council-award-665634","commercialisation TridimensiOnal Nanoporous ALumIna Templates","€149,953","One of the results obtained under the project nano-TEC (ERC-StG-240497) is an alumina template with three-dimensional nanopore architecture. This novel structure and its fabrication procedure have been the subject of a patent that has been recently filed. This structure has the novelty of being composed not only by vertically aligned pores, but also by tailor-controlled horizontal pores interconnecting them with their closest neighbour creating a three-dimensional net of nanopores. This template",{"id":114,"funder":7,"programme":8,"title":115,"piName":10,"institution":11,"country":12,"year":13,"amount":38,"abstract":116},"cordis-european-research-council-award-639758","Optical Coherence Tomography for Intraocular Lenses","The replacement of the crystalline lens of the eye by an artificial intraocular lens (IOL) is one of the most frequent procedures worldwide (3 millions\u002Fyear in Western Europe). The surgery is required to correct for the age-related loss in transparency (cataract), but it is also performed to correct for refractive errors, and may be envisioned to correct for presbyopia in a younger population (>45) with future accommodating IOLs that restore the eye focusing capability. Despite the development o",{"id":118,"funder":7,"programme":8,"title":119,"piName":10,"institution":120,"country":65,"year":13,"amount":121,"abstract":122},"cordis-european-research-council-award-665654","Personal perception for predicting product choice","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€135,776","The project will take a new technique devised in my ERC Advanced Investigator grant that measures implicit social biases in perception and applies it to the fields of sales and marketing. These fields have previously been reliant on paper-and-pencil tests which have a variety of problems including the faking of responses and vulnerability to demand characteristics. I have generated proof-of-principle evidence that my novel, tablet based measures of bias can be adapted to (i) measure product pref",{"id":124,"funder":7,"programme":8,"title":125,"piName":10,"institution":126,"country":127,"year":13,"amount":38,"abstract":128},"cordis-european-research-council-award-680880","Discovery of Bcl-3 inhibitors as Potential Chemopreventive Agent for skin cancer","LUNDS UNIVERSITET","SE","Melanoma is one of the fastest growing cancers worldwide, especially in regions with a high number of Caucasians such as Europe. Currently, 100,000 diagnoses and 5,000 deaths from melanoma are registered in Europe every year. This increase in melanoma incidence is a serious health problem and poses an economic as well as societal concern. The survival in patients with malignant melanoma is very poor with a five year survival rate of about 10%. Indeed, the current clinical therapies against malig",{"id":130,"funder":7,"programme":8,"title":131,"piName":10,"institution":132,"country":127,"year":13,"amount":38,"abstract":133},"cordis-european-research-council-award-680884","Platform for Heterogeneous Integration of NEMS on ICs","KUNGLIGA TEKNISKA HOEGSKOLAN","Within the ERC-M&M´s Starting Grant project (No.277879) we are exploring an innovative platform technology for wafer-level heterogeneous integration of integrated circuits (ICs) with micro\u002Fnano-electromechanical systems (MEMS\u002FNEMS). This type of heterogeneous 3D integration technology is part of the More-than-Moore paradigm depicted in the International Technology Roadmap for Semiconductors (ITRS)  and allows the combination of standard CMOS-based integrated circuits and high-performance MEMS de",{"id":135,"funder":7,"programme":8,"title":136,"piName":10,"institution":137,"country":25,"year":13,"amount":38,"abstract":138},"cordis-european-research-council-award-665647","Silencing miR-199b to attenuate the progression of heart failure.","UNIVERSITEIT MAASTRICHT","Cardiac hypertrophy is the principal risk factor for the development of heart failure and lethal arrhythmias. A complex web of interconnected signalling pathways has been implicated in hypertrophy and species of non-coding RNA molecules, microRNAs, have been shown to regulate these pathways. The recognition of microRNAs as potential therapeutic targets marks the principal step towards new therapeutic concepts. The SIRENE project represents the advancement of the therapeutic strength of miRNA sil",{"id":140,"funder":7,"programme":8,"title":141,"piName":10,"institution":142,"country":82,"year":13,"amount":33,"abstract":143},"cordis-european-research-council-award-640955","Antibody-free method for Counting All Circulating TUmour cellS while maintaining them alive and intact","UNIVERSITA DEGLI STUDI DI UDINE","The problem: Cancer metastases are responsible for 90% of cancer-associated deaths. Circulating tumour cells (CTCs) that enter the blood stream on their way to potential metastatic sites are of obvious interest to evaluate correctly patient treatment and therefore influence outcome. CTCs have been identified in bladder, gastric, prostate, lung, breast and colon cancer. The only FDA approved CTCs detection system is Veridex’ CellSearch, which detects only epithelial cancer cells using antibody la",{"id":145,"funder":7,"programme":8,"title":146,"piName":10,"institution":147,"country":148,"year":13,"amount":38,"abstract":149},"cordis-european-research-council-award-641384","Real-Time Monitoring System for Water Quality","UNIVERSITY OF CYPRUS","CY","Clean drinking water is a critical resource, important for the health and well-being of all humans. Uninterrupted supply of clean drinking water is considered a human right, thus water utilities must monitor and control the water quality following strict European and national regulations. A water contamination event can have a dramatic effect on everyday life, as well as on the local economy. Unfortunately, due to the large-scale and complex nature of water distribution systems, water quality mo",{"id":151,"funder":7,"programme":8,"title":152,"piName":10,"institution":153,"country":154,"year":13,"amount":155,"abstract":156},"cordis-european-research-council-award-680889","AcTafactors: Tumor Necrosis Factor-based immuno-cytokines with superior therapeutic indexes","VIB VZW","BE","€149,320","Tumor Necrosis Factor (TNF) is a homotrimeric pro-inflammatory cytokine that was originally discovered based on its extraordinary antitumor activity. However, its shock-inducing properties, causing hypotension, leukopenia and multiple organ failure, prevented its systemic use in cancer treatment. With this proof-of-concept study we want to evaluate a novel class of cell-targeted TNFs with strongly reduced systemic toxicities (AcTafactors). In these engineered immuno-cytokines, single-chain TNFs ",{"id":158,"funder":7,"programme":8,"title":159,"piName":10,"institution":160,"country":82,"year":13,"amount":161,"abstract":162},"cordis-european-research-council-award-665635","Mid Infrared SpectrometerS by an Innovative Optical iNterferometer","POLITECNICO DI MILANO","€149,625","The MISSION projects aims at bringing to the market a revolutionary concept of mid-infrared (MIR) interferometer, for a new generation of compact, low-cost, rugged spectrometers. Many applications of chemistry,  materials science and life sciences  require analysis and identification of  substances based on their vibrational absorption spectra in the MIR. Time domain vibrational spectroscopy  techniques such as FTIR and 2DIR are based on the use of an optical Michelson interferometer, producing ",{"id":164,"funder":7,"programme":8,"title":165,"piName":10,"institution":166,"country":167,"year":13,"amount":38,"abstract":168},"cordis-european-research-council-award-641166","The EDUCAGE: A Behavioral Platform for Naturalistic Learning","THE HEBREW UNIVERSITY OF JERUSALEM","IL","Understanding behavior is still one of the holy grails in the natural and social sciences. Behavior is often utterly complex because it is a result of an extremely rich set of past experiences, the present state of the animal and the animal’s predictions about the future; all of which affect learning, decision making and consequently behavior. Given the complexity of behavior, most researchers work in the realm of highly simplified learning tasks but these only test very basic attributes of lear",{"id":170,"funder":7,"programme":8,"title":171,"piName":10,"institution":172,"country":173,"year":13,"amount":174,"abstract":175},"cordis-european-research-council-award-665215","Electric-field driven magnetic domain wall motion for memory technologies","AALTO KORKEAKOULUSAATIO SR","FI","€149,778","Memory technologies that are used in computers, smart phones, tablets, etc. can be coarsely divided into two classes: fast but volatile DRAMs (dynamic random access memory) and non-volatile flash memories. Racetrack memory based on the controlled motion of magnetic domain walls is a promising new technology for next generation memories, because it combines the speed of DRAMs and the non-volatile properties of flash memories. One key drawback, however, is the required use of intense electric curr",{"id":177,"funder":7,"programme":8,"title":178,"piName":10,"institution":147,"country":148,"year":13,"amount":10,"abstract":179},"cordis-european-research-council-award-640862","Virtual Environments for Social Training","Autism spectrum disorder (ASD) is a clinical diagnostic label used to characterize a wide array of individuals exhibiting some common degree of core difficulty in the domain of social communication. This difficulty is reflected in contextually inappropriate social behavior, limited understanding of social norms, expectations, and others’ mental states, eye gaze abnormalities, etc. Such impairments often lead to social exclusion and failure to develop age-appropriate peer relationships. Although ",{"id":181,"funder":7,"programme":8,"title":182,"piName":10,"institution":183,"country":154,"year":13,"amount":184,"abstract":185},"cordis-european-research-council-award-664876","Development of the Gas-Solid Vortex-Rotor Reactor","UNIVERSITEIT GENT","€149,900","The project includes Proof-of-Concept research, as well as preparation and submission of a new patent application. The intention of the current proposal is to develop a novel gas-solid reactor that drastically reduces the limitations of these reactors. Moreover, novel fields of applications will be sought. This new Intellectual Property of UGent will be a subject of its following licensing.",{"id":187,"funder":7,"programme":8,"title":188,"piName":10,"institution":189,"country":12,"year":13,"amount":190,"abstract":191},"cordis-european-research-council-award-664910","ASSESSMENT AND INITIAL STEPS FOR THE EXPLOITATION OF A FAST SIMULATION SOFTWARE FOR CASTING MANUFACTURING OPERATIONS","CENTRE INTERNACIONAL DE METODES NUMERICS EN ENGINYERIA","€149,963","In the FORECAST PoC we will explore the industrial applicability and potential for commercialization of the new fast simulation technology developed in REALTIME for the enhanced design of mould filling processes in casting manufacturing operations of mechanical components.The computational technology tested In the FORECAST PoC will allow the casting industry, and in particular SMEs, to solve mould filling problems in times useful for taking decisions helping the design and operation of casting p",{"id":193,"funder":7,"programme":8,"title":194,"piName":10,"institution":195,"country":25,"year":13,"amount":196,"abstract":197},"cordis-european-research-council-award-665317","Exploiting vulnerabilities in protein synthesis for cancer diagnosis and therapy","STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS","€149,500","Tumor growth requires continuous synthesis of proteins, nucleic acids and lipids that are important components of the cell. Demand for amino acids as the building blocks for protein synthesis in rapidly dividing tumor cells is often much higher than that of normal cells. Such increased demand can represent a vulnerability of the tumor. Importantly, this vulnerability is already being exploited for therapy in one instance: Addition of L-asparginase - an enzyme lowering the concentration of the am",{"id":199,"funder":7,"programme":8,"title":200,"piName":10,"institution":132,"country":127,"year":13,"amount":201,"abstract":202},"cordis-european-research-council-award-665630","Industrial implementation of adaptive computational methods for turbulent flow and fluid-structure interaction","€146,897","The ERC StG project UNICON (Project ID 202984) was completed in July 2013. The goal of UNICON was to develop new adaptive finite element methods for computer simulation of fluid-structure interaction, in particular for problems involving turbulent flow. Simulation of turbulent flow is an outstanding computational challenge, where the UNICON project made significant progress beyond the state of the art. The scientific results of the UNICON project include a new theoretical and methodological fram",{"id":204,"funder":7,"programme":8,"title":205,"piName":10,"institution":206,"country":65,"year":13,"amount":10,"abstract":207},"cordis-european-research-council-award-665632","Hybrid Membranes Incorporating Metal-Organic Frameworks","THE UNIVERSITY OF MANCHESTER","Research undertaken on ERC Advanced Grant 226593 (COORDSPACE) has delivered a new exciting range of metal organic frameworks (MOFs). These substances show ultra-high porosity and this makes them ideal for many high value commercial applications, including gas separations. Of specific interest is NOTT-300, a unique, porous solid with exceptional, selective, CO2 and SO2 uptake properties and remarkable acetylene vs ethylene, ethylene vs ethane, and CO2 vs CH4 separation abilities. We now target th",{"id":209,"funder":7,"programme":8,"title":210,"piName":10,"institution":211,"country":12,"year":13,"amount":212,"abstract":213},"cordis-european-research-council-award-641302","Drug eDesign: Building the next generation of software solutions for drug design","BARCELONA SUPERCOMPUTING CENTER CENTRO NACIONAL DE SUPERCOMPUTACION","€148,875","Computer simulations are taking over in design processes. Nevertheless, complex projects will largely benefit from humanintuition and team-work. We aim to combine computer and human power into the next generation of fully interactivecomputational tools for drug design. The goal of eDRUG is prove the potential of this novel computational solution in thecurrent pipeline of drug development and the prospective interest that it will raise in the pharmaceutical industry.We aim at merging human knowle",{"id":215,"funder":7,"programme":8,"title":216,"piName":10,"institution":217,"country":167,"year":13,"amount":38,"abstract":218},"cordis-european-research-council-award-654816","High-throughput drug screening for identifying personalized cancer treatments tailored to the particular mutations of the patient’s tumor","WEIZMANN INSTITUTE OF SCIENCE","Cancer is caused by a series of genetic alterations that confer an advantage to cancer cells, leading to uncontrolled growth. However, each tumor exhibits distinct molecular changes, making each patient’s malignancy unique. Hence, in the personalized medicine era, cancer treatment aims to tailor the most suitable treatment for each patient according to his\u002Fher genetic background, tumor acquired mutations and clinical indications.The p53 tumor suppressor is the most frequently mutated gene in hum",{"id":220,"funder":7,"programme":8,"title":221,"piName":10,"institution":222,"country":65,"year":13,"amount":223,"abstract":224},"cordis-european-research-council-award-665639","Highly Conductive Graphene Ink","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€149,949","Graphene's unique electrical and optical properties make it ideal for a variety of applications, in particular for flexible (opto)electronic devices, such as mobile phones, tablets etc. Current flexible electronic devices are based on organic semiconducting materials with excellent current switching but poor charge carrier mobility, which result in a slow response. HiGRAPHINK aims to unlock this limitation by demonstrating the viability of graphene as additive to printed organic semiconducting m",{"id":226,"funder":7,"programme":8,"title":227,"piName":10,"institution":228,"country":167,"year":13,"amount":38,"abstract":229},"cordis-european-research-council-award-664800","Hand pose and gesture analysis for next generation device interaction","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","A touch-less, markerless interface for next generation Virtual Reality headsets and laptops (with embedded 3D sensors expected early 2015), will be possible only when accurate and robust finger and hand pose detection is available and developers can easily build applications with these natural interfaces. Solutions based on color cameras are problematic because of the restrictions on environment lighting, complex backgrounds and varied skin tones. A recent breakthrough during research within our",{"id":231,"funder":7,"programme":8,"title":232,"piName":10,"institution":233,"country":25,"year":13,"amount":38,"abstract":234},"cordis-european-research-council-award-665656","Launching Acoustic Force Spectroscopy - unlocking the potential of biomolecular bungee jumping","STICHTING VU","ACOFORS has been designed with the ultimate goal of preparing commercialisation of Acoustic Force Spectroscopy (AFS). AFS is a completely new and powerful technique for determining biomolecular mechanics and structure of single molecules such as DNA and proteins. These studies are performed on a large scale by biologists and within pharmaceutical companies for e.g. drug discovery and development. Current technologies for force spectroscopy (FS) represent a $50+ million market, but are expensive,",{"id":236,"funder":7,"programme":8,"title":237,"piName":10,"institution":238,"country":32,"year":13,"amount":239,"abstract":240},"cordis-european-research-council-award-680901","spim4You: customised solutions for light sheet microscopes and imaging data analysis.","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€148,613","Biological research heavily relies on visualization of biological samples by microscopy. In recent years light-sheet microscopy has emerged as a paradigm shifting technique. Only with light sheet microscopy it is for instance possible to follow every cell in a living system throughout development, to monitor brain activity of a live animal or to study cancer cells in their native three dimensional environment within an organism. Thus, light sheet microscopy has the potential to revolutionize bio",{"id":242,"funder":7,"programme":8,"title":243,"piName":10,"institution":244,"country":65,"year":13,"amount":245,"abstract":246},"cordis-european-research-council-award-680879","Add-on module for optical coherence tomography with en-face view option","UNIVERSITY OF KENT","€149,917","By the end of the 4th year of the ERC Advanced grant, the PI has set up the basis of a unique procedure to perform optical coherence tomography (OCT) that is similar in outcome to time domain interferometry but has all advantages of spectral domain interferometry in terms of speed and sensitivity. The new method of OCT, termed as Master\u002FSlave (MS), is characterised by several advantages: direct production of an en-face OCT image, tolerance to dispersion that allows MS-OCT to achieve the theoreti",{"id":248,"funder":7,"programme":8,"title":249,"piName":10,"institution":250,"country":251,"year":13,"amount":38,"abstract":252},"cordis-european-research-council-award-680920","A Hot-Spot Bio-Barcode Strategy for Prognostic Biomarkers In Colorectal Cancer","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","CH","Colorectal cancer (CRC) is caused by alterations in genes that regulate tissue growth and the risk of developing CRC is influenced by a combination of environmental and genetic factors. Although CRC is often preventable by removing precursor lesions, screening efforts have been hampered by low participation rates and by performance limitations of the screening tools themselves. Detection of blood in faeces is currently the most common screening tool, while stool DNA testing of molecular markers ",{"id":254,"funder":7,"programme":8,"title":255,"piName":10,"institution":228,"country":167,"year":13,"amount":38,"abstract":256},"cordis-european-research-council-award-692804","Structure-based subwavelength imaging","Until recently it was believed to be impossible to perform optical imaging with resolution beyond the fundamental resolution limit. However, in the past few years, our team was able to algorithmically enhance the resolution of optical imaging, bringing it to below one fifth of the optical wavelength. This achievement is based on the prior knowledge that the image is “sparse”, that is, the image can be represented in a compact form in an appropriate mathematical basis. The purpose of this PoC is ",{"id":258,"funder":7,"programme":8,"title":259,"piName":10,"institution":260,"country":261,"year":13,"amount":10,"abstract":262},"cordis-european-research-council-award-640492","Biofouling control in nanofiltration and reverse osmosis processes using a smart polymer approach","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","IE","Nanofiltration (NF) and reverse osmosis (RO) membranes are widely and increasingly used for water treatment process.The efficiency of NF and RO processes is however adversely affected by biofouling. Environmental stimuli can trigger selfcleaningmechanisms of natural surfaces. Consequently there is an increasing interest in developing smart or stimuliresponsive polymers as coatings to prevent biofouling. However, external chemical\u002Fphysical stimuli must be selectivelyapplied to the smart polymers ",{"id":264,"funder":7,"programme":8,"title":265,"piName":10,"institution":266,"country":82,"year":13,"amount":267,"abstract":268},"cordis-european-research-council-award-665421","ToothPic, a large-scale camera identification system based on compressed fingerprints","POLITECNICO DI TORINO","€149,526","The continuously growing amount of photos posted and distributed over the Internet poses several important problems related to improper use of images, such as exploiting them for commercial purposes, re-posting others’ photos without consent or infringing copyright, posting photos containing unethical or illegal contents, and so forth. Camera identification, which refers to identifying which digital imaging sensor has shot a given picture, exploiting the fact that each sensor leaves a unique fin",{"id":270,"funder":7,"programme":8,"title":271,"piName":10,"institution":272,"country":65,"year":13,"amount":273,"abstract":274},"cordis-european-research-council-award-665712","Optical Ultrasound Imaging for Real-time Guidance of Intracardiac Procedures","UNIVERSITY COLLEGE LONDON","€149,624","This European Research Council Proof of Concept grant is focused on translating a new medical device for interventional cardiology from a proven laboratory prototype to a commercial prototype. The core innovation in this medical device is a new type of ultrasound imaging probe that can be readily integrated into medical devices to guide minimally invasive procedures. Current generation probes, which are based on electrical methods of ultrasound generation, involve complex fabrication processes t",{"id":276,"funder":7,"programme":8,"title":277,"piName":10,"institution":278,"country":32,"year":13,"amount":38,"abstract":279},"cordis-european-research-council-award-641415","Blue Combustion for the Storage of Green Electrical Power","TECHNISCHE UNIVERSITAT BERLIN","The detrimental consequences of global warming and the scarceness of fossil energy resources make an increasing use of renewable energy sources imperative. However, the inherent volatility of most of these energy sources requires both the installation of fast fossil backup power and large amounts of storage capacity. In the ERC funded project GREENEST the fundamentals of an ultra-wet gas turbine cycle are developed. In the proposed project BlueStep :  Blue Combustion for the Storage of Green Ele",{"id":281,"funder":7,"programme":8,"title":282,"piName":10,"institution":283,"country":12,"year":13,"amount":38,"abstract":284},"cordis-european-research-council-award-680898","Reconfigurable smart lens for adaptive imaging","FUNDACIO INSTITUT DE CIENCIES FOTONIQUES","Adaptive optical elements that enable dynamic control of optical paths are essential components of the last generation of commercial optical devices in a wide range of sectors, including smart phones, microscopy and 3D printing. The main goal of the SMARTLENS project is to exploit a recently developed technology to create a new paradigm in optical imaging by transforming at low cost any conventional static optical lens into an adaptive lens whose imaging properties can be dynamically shaped almo",{"id":286,"funder":7,"programme":8,"title":287,"piName":10,"institution":288,"country":82,"year":13,"amount":38,"abstract":289},"cordis-european-research-council-award-640849","New chemical detection methods based on NMR and nanoparticles","UNIVERSITA DEGLI STUDI DI PADOVA","Chemicals detection is a crucial problems that Chemistry is addressing since its origin and one of the most important in the everyday life (diagnosis, environment analysis). The most common analytical techniques (chromatography, mass spectrometry, Elisa assays) are able to efficiently separate and detect the target compound but provide only indirect information on its identity and may fail in the identification of new compounds. On the other hand, Nuclear Magnetic Resonance (NMR) spectrometry is",{"id":291,"funder":7,"programme":8,"title":292,"piName":10,"institution":166,"country":167,"year":13,"amount":293,"abstract":294},"cordis-european-research-council-award-639314","A potent Micro-RNA therapeutic for nonalcoholic fatty liver disease (NAFLD)","€149,800","Fatty Liver disease (FLD) is a widespread disease which can often progress to Nonalcoholic steatohepatitis, cirrhosis and liver cancer. At present FLD disease affects a huge perportion of the population and prompt treatment will be of major health benefits to the general population. We have developed a specific therapeutic targeting a microRNA we and others have shown to be involved in the pathogenesis of FLD. This therapeutic agent can dramatically reduce FLD in a mouse model. We would like to ",{"id":296,"funder":7,"programme":8,"title":297,"piName":10,"institution":183,"country":154,"year":13,"amount":298,"abstract":299},"cordis-european-research-council-award-641353","INTERconnects enhanced by colloidal qDOT based optical amplifiers","€145,000","In the ERC project ULPICC, a new type of optical amplifier was invented that is much more compact than existing optical amplifiers based on rare earth doping and much cheaper to fabricate than the ones based on III-V semiconductors. It is based on our discovery that HgTe colloidal quantum dots (QDs) exhibit a gain threshold several orders of magnitude lower than any other type of QDs studied before.  Semiconductor QDs are fabricated using wet chemical synthesis procedures and can be deposited wi",{"id":301,"funder":7,"programme":8,"title":302,"piName":10,"institution":303,"country":25,"year":13,"amount":304,"abstract":305},"cordis-european-research-council-award-665619","A new instrument for mapping the ultrafast photo-conductivity of materials for optoelectronics","STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN","€148,750","The introduction of new photo-active materials with enhanced performance is enabling a fast technological development in fields such as photovoltaics, photodetection, display technology and imaging systems.  The efforts on the improvement of the synthesis and growth of these materials are in many cases not accompanied with equal efforts on the development of appropriate techniques that enable their characterization. MicroMap aims to develop a commercial instrument for the contact-free characteri",{"id":307,"funder":7,"programme":8,"title":308,"piName":10,"institution":206,"country":65,"year":13,"amount":309,"abstract":310},"cordis-european-research-council-award-692645","A new architecture for visual display technology based upon recent advances in our understanding  of visual physiology.","€149,250","The last twenty years has seen a huge improvement in the quality of images produced by commercial visual display units. Nevertheless, they still do not fully recreate the range of sensations we experience during natural vision. We have designed a prototype visual display that will allow us to take advantage of recent developments in visual neurophysiology to address that limitation. We request funds to construct this prototype and explore its performance as a necessary proof of concept for its c",{"id":312,"funder":7,"programme":8,"title":313,"piName":10,"institution":250,"country":251,"year":13,"amount":314,"abstract":315},"cordis-european-research-council-award-665718","Automated Microhandling System for X-ray Crystallography","€148,885","Crystallography is one of the most important methods for studying the 3D structure of complex biological macromolecules. The knowledge of the detailed structure of proteins, enzymes and chromatin allows scientists to understand concepts such as bimolecular interactions, mechanism of enzymatic catalysis and the therapeutic action of drug molecules. A major bottleneck of high-throughput crystallography is harvesting the crystallized form of these molecules from their liquid environments and manipu",{"id":317,"funder":7,"programme":8,"title":318,"piName":10,"institution":319,"country":320,"year":13,"amount":38,"abstract":321},"cordis-european-research-council-award-665216","Commercialization of Wear3D - Wearable and 3D Display Technology","KOC UNIVERSITY","TR","Wear3D display technology project is an ERC-Advanced project and offers novel optical solutions for wearable (or head-mounted) displays to achieve very wide field-of-view and natural-looking 3D. The Wear3D technology has a lot of potential as the global consumer market for Head Mounted Displays market was valued at USD 342.7 million in 2011, and is expected to reach US$9.3 billion by 2019.The Wear3D technology is very strong on IPR position and the initial results obtained in the lab are very pr",{"id":323,"funder":7,"programme":8,"title":324,"piName":10,"institution":325,"country":25,"year":13,"amount":326,"abstract":327},"cordis-european-research-council-award-665683","A Nano-electrode chip for high-resolution\u002Fhigh-throughput cellular assays in cultured neurons including synaptic tranmission","STICHTING AMSTERDAM UMC","€149,475","Cellular studies in neuroscience are hampered by the fact that in vitro cultures of primary neurons are complex, variable and heterogeneous, making studies on cultured neurons time consuming, labour intensive and not scalable. Especially for single cell studies on synaptic transmission and cellular trafficking, this is a major limitation. Both in academia and industry, mitotic cells are commonly used as a proxy for neurons (e.g. PC12 cells). However, while being less variable and better scalable",{"id":329,"funder":7,"programme":8,"title":330,"piName":10,"institution":331,"country":261,"year":13,"amount":332,"abstract":333},"cordis-european-research-council-award-665777","miRNA-activated Scaffold Technologies for Cartilage Regeneration","ROYAL COLLEGE OF SURGEONS IN IRELAND","€149,450","Adult articular cartilage has a limited capacity for repair so when damaged it can lead to joint degeneration and ultimately osteoarthritis. In our lab we have had significant success in enhancing tissue regeneration by functionalising collagen-based scaffolds for the delivery of therapeutic genes. In this project we propose to apply this concept for the delivery of microRNAs to promote enhanced cartilage repair.",{"id":335,"funder":7,"programme":8,"title":336,"piName":10,"institution":337,"country":65,"year":13,"amount":38,"abstract":338},"cordis-european-research-council-award-665696","Compliant Actuation Robotic Platform for Flexible Endoscopy","UNIVERSITY OF DUNDEE","Prof Alfred Cuschieri, the overall coordinator of ERC grant Colonic Disease Investigation by Robotic Hydro-colonoscopy (CODIR - grant agreement 268519) has recently submitted the mid-term scientific report on behalf of the two participating Universities (Dundee and Leeds), which highlights several novel IPR (intellectual property rights) issues resulting from the CODIR research, which are pertinent to robotic flexible endoscopy. One of these is based on the ‘active tether robot’ (ATR) idea for t",{"id":340,"funder":7,"programme":8,"title":341,"piName":10,"institution":342,"country":82,"year":13,"amount":38,"abstract":343},"cordis-european-research-council-award-680766","Developing new therapeutics for Friedreich ataxia","UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA","Friedreich ataxia (FRDA) is a devastating neurodegenerative orphan disease that affects children and young adults, and has no approved therapy. The disease progressively brings patients to severe disability and significantly reduces life expectancy. The genetic defect underlying the disease causes FRDA patients to produce only low amounts of the mitochondrial protein frataxin, compared to normal subjects. Low frataxin results in the accelerated death of peripheral sensory neurons, causing the di",{"id":345,"funder":7,"programme":8,"title":346,"piName":10,"institution":319,"country":320,"year":13,"amount":38,"abstract":347},"cordis-european-research-council-award-641156","KidsSurgicalPlan: An Internet enterprise for sketch-based cardiovascular pre-surgical planning","Approximately 1 in 100 children are born with a clinically significant congenital heart defect representing 47,000 children each year in the EU. Survival of the newborn requires series of complex open-heart surgeries where optimal hemodynamic performance is essential for improved post-operative quality of life. This work proposes a new computationally-enhanced interactive system for patient-specific pre-surgical design and optimization of pediatric cardiovascular surgeries. With the proposed sys",{"id":349,"funder":7,"programme":8,"title":350,"piName":10,"institution":351,"country":65,"year":13,"amount":352,"abstract":353},"cordis-european-research-council-award-665349","INTRASTEM: High Efficiency Delivery of Proteins, Nucleic Acids and Particles to Human Cells","THE UNIVERSITY OF NOTTINGHAM","€147,489","Under an ERC Advanced Grant, Professor Shakesheff's team have invented a new intracellular delivery system that overcomes a problem in pluripotent stem cell culture as well as being applicable to many other mammalian cell types. The system, called GAG-binding enhanced transduction (GET), enables intracellular delivery of proteins, nucleic acids and particles into cells that resist other non-viral strategies. The work under ERC Advanced Grant funding has allowed exemplification of the delivery of",{"id":355,"funder":7,"programme":8,"title":356,"piName":10,"institution":357,"country":261,"year":13,"amount":358,"abstract":359},"cordis-european-research-council-award-641392","Medically Licensed Mesenchymal Stem Cells for Acute Respiratory Distress Syndrome.","UNIVERSITY OF GALWAY","€149,101","Acute Respiratory Distress Syndrome (ARDS) is a devastating condition, which kills 40% of sufferers, resulting in hundreds of thousands of deaths worldwide annually. Despite decades of intensive research efforts, there are no clinical therapeutic strategies available for this catastrophic condition. In our ERC Starter Grant, HA-NFkB-VILI, we have shown Mesenchymal Stem Cells (MSCs) to be beneficial in several relevant preclinical ARDS models. However, for cell therapies to be successfully used i",{"id":361,"funder":7,"programme":8,"title":362,"piName":10,"institution":217,"country":167,"year":13,"amount":38,"abstract":363},"cordis-european-research-council-award-677645","Commercialization of a novel tool for designing personalized nOvel MelAnoma Therapies","Melanoma tumours develop in the pigment cells located in the skin. It is the most aggressive and treatment-resistant type of skin cancer as well as the leading cause of death among skin diseases. Moreover, melanoma’s alarming increase in incidence, especially in the young population, in combination with its propensity for lethal metastasis, illustrates an urgent need for new treatment strategies. In this PoC project, we propose developing an innovative tool, called COMbAT, for designing highly p",{"id":365,"funder":7,"programme":8,"title":366,"piName":10,"institution":367,"country":32,"year":13,"amount":88,"abstract":368},"cordis-european-research-council-award-665456","A Streptavidin Microarray Platform for Capturing of Circulating Tumor Cells from the Blood of Cancer Patients","UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF","The main cause of death in cancer patients is not the primary tumor but rather metastasis, which is initiated by the spread of circulating tumor cells (CTCs) in the blood. Therefore, CTCs will become a valuable diagnostic tool, once a reliable, cost-effective method is established. Research in the ongoing ERC Advanced Investigator Grant DISSECT (PI: Klaus Pantel) has revealed clear limitations of existing platforms for the detection of CTCs. The enrichment and identification of CTCs out of a blo",{"id":370,"funder":7,"programme":8,"title":371,"piName":10,"institution":372,"country":82,"year":13,"amount":38,"abstract":373},"cordis-european-research-council-award-641388","PETRA - Photonic Environment moniToring Risk Assessment","CONSORZIO NAZIONALE INTERUNIVERSITARIO PER LE TELECOMUNICAZIONI","The goal of PETRA (Photonic Environment moniToring & Risk Assessment) is the design and the IPR transfer of a radically new precommercial photonics based prototype for noninvasive continuous remote monitoring system for geo-technical risk assessment. PETRA will step from the ERC-funded project PHODIR that successfully carried out the realization and the field trial of the first photonic based radar prototype, and from the contacts that were made between CNIT and industrial partners during the Po",{"id":375,"funder":7,"programme":8,"title":376,"piName":10,"institution":377,"country":25,"year":13,"amount":38,"abstract":378},"cordis-european-research-council-award-665684","Membrane fusion mediated dermal allergy immunotherapy","UNIVERSITEIT LEIDEN","In this project we aim to develop a new delivery platform for allergy vaccines with a high efficacy and a high safety profile combining membrane fusion-mediated delivery and microneedle-based dermal delivery.Background: Within the ERC Starting Grant “Direct Drug Delivery”, I developed a method for the controlled fusion of liposomes with cells. A set of complementary peptide amphiphiles (coilK and coilE), able to form heterodimeric coiled coils, were shown to induce targeted and efficient fusion ",{"id":380,"funder":7,"programme":8,"title":381,"piName":10,"institution":382,"country":251,"year":13,"amount":38,"abstract":383},"cordis-european-research-council-award-680552","ULTrafast Imaging sensor for Medical Applications","ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE","Breast cancer is the most common cause of death among women. For lowering the mortality rates and improving life quality, it would be beneficial to diagnose and treat diseases early.Dedicated Positron Emission Tomography (PET) application Positron Emission Mammography (PEM) has been developed for functional medical imaging of specific breast cancer biomarkers. PEM enables accurate detection of small malignant tumors at an earlier stage. However, it suffers from major limitations on becoming suit",{"id":385,"funder":7,"programme":8,"title":386,"piName":10,"institution":387,"country":173,"year":13,"amount":38,"abstract":388},"cordis-european-research-council-award-641346","BreAking the Link betweeN myo10 and CancEr","TURUN YLIOPISTO","Breast cancer is the most frequently diagnosed cancer form and the leading cause of death among women while pancreatic cancer is the fourth commonest cause of cancer-related mortality across the world and very difficult to treat due to its aggressive nature and the relative lack of curative options. A major impediment in the identification of new therapeutic targets lies in our limited understanding of the exact mechanisms taking place within the tumor microenvironment that are responsible for t",{"id":390,"funder":7,"programme":8,"title":391,"piName":10,"institution":392,"country":12,"year":13,"amount":393,"abstract":394},"cordis-european-research-council-award-680908","New breast cancer therapies based on available p38 MAPK inhibitors","FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)","€149,995","Breast tumors are classified by several grading systems and divided into four main molecular subtypes: Luminal A, Luminal B, Triple negative\u002Fbasal-like and HER2+. Since luminal A tumors tend to be ER+, their treatment often includes hormonal therapy. HER2+ tumors can be treated with Trastuzumab, an anti-Her2 receptor antibody. Hormonal therapies or Trastuzumab cannot be used for triple negative tumors, which are ER- and HER2-, and these are usually treated with a combination of surgery, radiothe",{"id":396,"funder":7,"programme":8,"title":397,"piName":10,"institution":398,"country":58,"year":13,"amount":38,"abstract":399},"cordis-european-research-council-award-678563","Epigenetic Profiling of Chemotherapy Efficacy","INSTITUT CURIE","The aim of this proposal is to showcase that chromatin regulators represent a novel class of biomarkers that can predict the response to individual drugs. The proof of concept will be established by validating our recent discovery of a 28-gene signature of chromatin regulators that predicts the response of 26 out of 31 patient-derived xenograft breast cancer models to docetaxel. Notably, in patients treated with docetaxel, though all are subjected to toxic side effects, less than half of them cl",{"id":401,"funder":7,"programme":8,"title":402,"piName":10,"institution":166,"country":167,"year":13,"amount":38,"abstract":403},"cordis-european-research-council-award-641152","Treatment of EGFR over-expressing cancers by targeted non-viral delivery of PolyIC","We have recently shown that application of EGFR targeted synthetic dsRNA: Poly Iosine\u002FPoly Cytosine (pIC) is highly efficient and selective against deadly cancers overexpressing EGFR, like glioblastoma (U87MGwtEGFR), breast cancer (MDA-MB-468) and adenocarcinoma (A431). Double-stranded RNA, frequently expressed in cells infected with viruses, activates a number of pro-apoptotic processes simultaneously. These dsRNA-induced mechanisms efficiently kill infected cells and induce expression of anti-",{"id":405,"funder":7,"programme":8,"title":406,"piName":10,"institution":407,"country":408,"year":13,"amount":409,"abstract":410},"cordis-european-research-council-award-665633","A gene expression test in blood for breast cancer","UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET","NO","€143,933","The aim of BLOBREC is to develop a blood-based test for the diagnosis of breast cancer. The test is based on results from gene expression analyses in a hospital based nested case-control study in the Norwegian Women and Cancer postgenome cohort study. The controls are healthy population controls from the same cohort. The innovative potential of a gene expression test is the independency from other test for breast cancer like imaging technologies (mammograms, ultrasound, MR) and pathological diag",{"id":412,"funder":7,"programme":8,"title":413,"piName":10,"institution":217,"country":167,"year":13,"amount":38,"abstract":414},"cordis-european-research-council-award-633888","Ultrafast Spatiotemporally-Encoding: A Superior Approach to Cancer Diagnosis by Non-Invasive Diffusion-Weighted MRI","This proposal aims at commercializing a new method that can improve the detection and diagnosis of breast cancer.  Using ultrafast magnetic resonance (MR) acquisition schemes that span off our UltraNMR ERC AdG award, we have found ways to exploit our Spatiotemporally-Encoded (SPEN) principles together with diffusion measurements, for the rapid, safe and non-invasive diagnosis of breast malignancies. This SPENmr PoC could provide much cleaner, artifact-free alternatives than existing standards; p",{"id":416,"funder":7,"programme":8,"title":417,"piName":10,"institution":418,"country":58,"year":13,"amount":419,"abstract":420},"cordis-european-research-council-award-680875","Classical Levitonics: transposing quantum levitons to classical waves for single side band wireless data transmissions","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","€149,404","The project addresses the field of wireless digital communication. This field has constantly grown during the last twenty years with the development of cell phones and WiFi Local Area Network and with the development of digital TV broadcasting and satellite communications. A second expansion of digital communications has recently started with networks of objects: Bluetooth smart devices are available to consumers and RFID devices are used for object tagging, security identification and health se",{"id":422,"funder":7,"programme":8,"title":423,"piName":10,"institution":418,"country":58,"year":13,"amount":424,"abstract":425},"cordis-european-research-council-award-640997","SolarPredict: An advanced predictive tool and service of the Solar 11-yr Activity Cycle","€149,913","The main idea of the SolarPredict Proof of Concept project is to use physically based dynamo models to make solar 11-yr activity predictions, in particular of Earth impacting events, more robust\u002Freliable and to develop the tools to make them accessible (with the appropriate licencing and IPR) to customers (such as private corporations or governmental agencies) as a service, software or paid\u002Ffreemium applications. The key advantage of our tools\u002Ftechniques over current ones is both our deep knowle",{"id":427,"funder":7,"programme":8,"title":428,"piName":10,"institution":429,"country":25,"year":13,"amount":38,"abstract":430},"cordis-european-research-council-award-641280","Integrated quantum correlation counter","TECHNISCHE UNIVERSITEIT DELFT","Quantum correlation measurements are essential to study and analyze the statistics of light fields, to observe quantum entanglement and are central in several emerging applications of quantum optics such as quantum cryptography, ballistic imaging, logic gates, quantum repeaters, fluorescence correlation spectroscopy and optical tomography. The measurement techniques have not evolved much since the report of the first quantum correlation measurement in 1956: macroscopic optical elements are used ",{"id":432,"funder":7,"programme":8,"title":433,"piName":10,"institution":429,"country":25,"year":13,"amount":304,"abstract":434},"cordis-european-research-council-award-665477","Flow Visualization Based Pressure","The ERC-FLOVIST project has focused on advancing Tomographic Particle Image Velocimetry (PIV) towards a versatile technique for the non-intrusive diagnostics of aero-acoustic problems. One of the milestones has been the use of Tomo-PIV to infer the instantaneous three dimensional pressure field from the velocity measurement. The use of this laser-based technique for the detection of pressure fluctuations both around and on the surface of aerodynamic models offers the advantage that surface press",{"id":436,"funder":7,"programme":8,"title":437,"piName":10,"institution":438,"country":261,"year":13,"amount":439,"abstract":440},"cordis-european-research-council-award-665674","Ink-Jet printed supercapacitors based on 2D nanomaterials.","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","€149,774","This proposal will determine the technical-economic viability of scaling-up ultra-thin, ink-jet printed films based on liquid-phase exfoliated single atomic layers of a range of nanomaterials. The PI has developed methods to produce in liquid nanosheets of a range of layered materials such as graphene, transition metal oxides, etc. These 2D-materials have immediate and far-reaching potential in several high-impact technological applications such as microelectronics, composites and energy harvest",{"id":442,"funder":7,"programme":8,"title":443,"piName":10,"institution":444,"country":58,"year":13,"amount":38,"abstract":445},"cordis-european-research-council-award-640389","Preclinical development of squalenic acid and gemcitabine squalene nanomedicine","UNIVERSITE PARIS-SACLAY","In the course of the ERC Advanced Grant TERNANOMED, we have discovered that the linkage of squalene (a natural lipid) to many drugs, confers to the resulting bioconjugates the remarkable property to self-assemble as nanoparticles, due to the folded molecular conformation of squalene. This approach is unique and has never been used before. The so called squalenoylation technology may be considered as a generic platform to construct nanomedicines with high drug loading and targeted drug release tr",{"id":447,"funder":7,"programme":8,"title":448,"piName":10,"institution":57,"country":58,"year":13,"amount":449,"abstract":450},"cordis-european-research-council-award-665412","Medical Phase Contrast X-ray Imaging with Laser Plasma Accelerator","€149,851","Cancer detection at an early stage is crucial for subsequent therapy success. To achieve this goal, an effective screening should rely on a specific tool that should be not only non-invasive but also adaptable to patients and their diseases. Widely used nowadays, X-Ray imaging (RX) is a well-established cancer screening technique. However, it poses major problems of (i) detection of tumours at early stages when they are small and of low contrast, (ii) dose deposition in a body, especially for fr",{"id":452,"funder":7,"programme":8,"title":453,"piName":10,"institution":57,"country":58,"year":13,"amount":454,"abstract":455},"cordis-european-research-council-award-664738","Photon Cross Correlation Spectroscopy","€149,984","Across Europe, nearly 250,000 people die every year of sepsis, a severe bloodstream infection. Detecting molecular biomarkers indicative of bacterial infection within a limited time is vital to enable targeted antibiotics therapy, limit the risk of antimicrobial resistance and reduce hospitalization costs. The key to success to fight sepsis is a fast detection technology that avoids the need for nucleic acid amplification processes and circumvents the limitations of fluorescence labelling. The P",{"id":457,"funder":7,"programme":8,"title":458,"piName":10,"institution":459,"country":25,"year":13,"amount":38,"abstract":460},"cordis-european-research-council-award-665335","DNA rEpair impaired Mice with accElerated Neurodegeneration as Tool to Improve Alzheimer therapeutics","ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM","Alzheimer’s disease (AD) affects worldwide ~50 million people. Preclinical research relies mainly on transgenic mouse models overexpressing mutant human proteins that are altered in \u003C5% of AD cases (e.g. β-amyloid and tau), however, despite prominent protein aggregates, they fail to show the dramatic neurodegeneration and cognitive decline of patients, indicating that plaques and tangles may not be the only requirement for AD. Age is the most determining factor in AD, but is poorly represented i",{"id":462,"funder":7,"programme":8,"title":463,"piName":10,"institution":120,"country":65,"year":13,"amount":464,"abstract":465},"cordis-european-research-council-award-641317","Integral Membrane Proteins – an Approach to Rank Target Stability","€145,501","This Proof of Concept proposal is designed to develop and test a novel way of monitoring the effects of drug binding to membrane protein targets.  The idea stems from the basic research proposed in my ERC grant IMPRESS to study and rationalise the release of membrane proteins from detergent micelles in the gas phase of the mass spectrometer. During this research we discovered a new family of detergents, which we could formulate, to retain folded protein structure in the gas phase. Having achieve",{"id":467,"funder":7,"programme":8,"title":468,"piName":10,"institution":469,"country":167,"year":13,"amount":38,"abstract":470},"cordis-european-research-council-award-665020","An Automatic Microfluidic Device Assembly System","BAR ILAN UNIVERSITY","Microfluidic systems, in general, have proven important platforms for biomedical assays. These systems benefit from reduced requirements for expensive reagents, short analysis times, and portability. Although microfluidic systems are convenient platforms, their use in the life sciences is still limited mainly due to the high-level fabrication expertise required for construction. Integrated microfluidics is one of the most sophisticated three-dimensional (multi layer) solution. It requires soft l",{"id":472,"funder":7,"programme":8,"title":473,"piName":10,"institution":57,"country":58,"year":13,"amount":38,"abstract":474},"cordis-european-research-council-award-665482","A commercial device for mercury isotope monitoring (MIMO)","Mercury (Hg) is a toxic element with adverse effects on humans and wildlife. Cross-border export of atmospheric Hg emissions makes Hg a global pollutant. In 2013 the UNEP Minamata Convention on Mercury was signed by over 100 countries and aims to reduce future Hg emissions. Implementation of environmental Hg policy requires environmental monitoring efforts. Hg monitoring networks such as GMOS and AMNet typically gather data on atmospheric Hg concentrations, but do not provide information on the ",{"id":476,"funder":7,"programme":8,"title":477,"piName":10,"institution":64,"country":65,"year":13,"amount":393,"abstract":478},"cordis-european-research-council-award-641232","Zinc finger gene therapy in the brain for treating Huntington's disease","Huntington’s disease (HD) is a lethal inherited neurodegenerative disorder which currently has no cure. Patients develop a devastating loss of muscle control and brain function, with symptoms typically developing at 35 - 45 years of age, although they can start much earlier. Suffering is high for both patients and carers, with death generally occurring within 10 - 15 years of diagnosis. We are working on a novel, curative gene therapy approach based on reducing the levels of the HTT disease gene",{"id":480,"funder":7,"programme":8,"title":481,"piName":10,"institution":482,"country":251,"year":13,"amount":38,"abstract":483},"cordis-european-research-council-award-662449","Microfluidic platform for intra-operative tumor immunohistochemistry","ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE","We propose to develop an automated microfluidic platform for rapid analysis of the margins of frozen resections of tumors. It will allow cancer cells to be specifically distinguished from healthy cells during the time course of the surgical intervention itself via an immunohistochemistry (IHC) staining protocol completed in 5 minutes. The interest of such platform is that late-positivity, which is defined as the detection of cancer cells within the resection margin of the tumor by means of class",{"id":485,"funder":7,"programme":8,"title":486,"piName":10,"institution":482,"country":251,"year":13,"amount":487,"abstract":488},"cordis-european-research-council-award-680420","A mathematical platform for Abdominal Aortic Aneurism risk assessment and surgical planning","€147,400","Abdominal Aneurysm of the Aorta (AAA) is a degenerative disease of the last segment of the abdominal aorta, representing the 14th leading cause of death for the 60 to 85 year-old age group in US. An estimated 80 million people aged 60 years and older are at risk in Western Europe. To date the most commonly used clinical protocol for surgical acceptance is based on the estimate of  AAA diameter.  The report prepared for the Agency for Healthcare Research and Quality came to the conclusion that: t",{"id":490,"funder":7,"programme":8,"title":491,"piName":10,"institution":492,"country":65,"year":13,"amount":493,"abstract":494},"cordis-european-research-council-award-677124","Self-Enforcing Electronic Voting For Commercial Applications","UNIVERSITY OF NEWCASTLE UPON TYNE","€149,860","This project aims to commercialise Self-Enforcing E-Voting (SEEV), a new paradigm of verifiable e-voting technologies without involving any trusted tallying authorities (invented under the ERC starting grant No. 106591), for classroom voting and related applications. A prototype of a Verifiable Classroom Voting (VCV) system, based on the SEEV technology, has been developed by the PI's team at Newcastle University, and in the past two years has been successfully trialled in real classroom teachin",{"id":496,"funder":7,"programme":8,"title":497,"piName":10,"institution":238,"country":32,"year":13,"amount":498,"abstract":499},"cordis-european-research-council-award-640678","CoPIRL: Compact High Power Picosecond Infrared Laser for Scar Free Surgery and Bio-Diagnostics.","€78,125","The PIRL concept is the first method of any to achieve surgery without scar tissue formation. This new laser concept has achieved the long held promise for the laser for attaining the fundamental limit to minimally invasive surgery.  The very prospect of high precision surgery without scar tissue formation is readily appreciated to potentially revolutionize surgery and holds equally great promise in providing in situ bio-diagnostics.The goal of this work is to develop a more compact and higher p",{"id":501,"funder":7,"programme":8,"title":502,"piName":10,"institution":503,"country":65,"year":13,"amount":504,"abstract":505},"cordis-european-research-council-award-665589","Development of a New Wavelength Scanning Interferometer for Embedded Metrology","UNIVERSITY OF HUDDERSFIELD","€149,662","The proposed EMInstr project aims to elevate the important research result, a lab prototype of a new wavelength scanning interferometer (NWSI) developed during the ERC-2008-ADG 228117 SURFUND project and to verify its potential as a commercial product. The EMInstr project intends to set up a commercialisation pathway: from verification\u002Fvalidation of the lab prototype, through to technical optimisation, product prototype design, technological licensing and finally into commercialisation. The expe",{"id":507,"funder":7,"programme":8,"title":508,"piName":10,"institution":509,"country":65,"year":13,"amount":510,"abstract":511},"cordis-european-research-council-award-640798","Digital Bridge: Optical Character Recognition for Early Printed Books in Latin","UNIVERSITY OF DURHAM","€148,178","This project aims to provide the first viable and accurate solution for digitising early printed books in Latin using Optical Character Recognition. Our basic OCR package will be free and open-source, in order to ensure affordability, longevity, and openness for improvement (three failures of our commercial competitors). Our Company Limited by Guarantee will market costumisation, training, support, and further development tailored to specific collections of books (the standard failure of open-so",{"id":513,"funder":7,"programme":8,"title":514,"piName":10,"institution":515,"country":12,"year":13,"amount":38,"abstract":516},"cordis-european-research-council-award-671839","Blocking SUMO conjugation as drug discovery strategy.","CENTRE DE RECERCA EN AGRIGENOMICA CSIC-IRTA-UAB-UB","In eukaryotes, SUMO (Small Ubiquitin Modifier) conjugation to proteins is an essential process that regulates many aspects of cell biology. Defects in SUMO conjugation have been associated to cancer, neurodegenerative diseases and others, raising a great interest in developing novel drugs for inhibiting SUMO conjugation.Specifically, recent reports have pointed to a high dependency on an active SUMO conjugation by Myc-overexpressing cancers. Consequently, SUMO conjugation has become a non-oncoge",{"id":518,"funder":7,"programme":8,"title":519,"piName":10,"institution":228,"country":167,"year":13,"amount":38,"abstract":520},"cordis-european-research-council-award-680899","Array-tagged single cell gene expression by parallel linear RNA amplification and sequencing","In many biomedical research and clinical applications it would be tremendously useful to know the gene expression profile of each and every cell in a sample, be it a blood sample or tumor. At present, the most advanced single-cell technologies are limited to a few thousand cells by a laborious and expensive approach. We have invented a method allowing the determination of the transcriptomes of millions of cells in parallel, using array-based technique for tagging single cells. The protocol combi",{"id":522,"funder":7,"programme":8,"title":523,"piName":10,"institution":524,"country":32,"year":13,"amount":525,"abstract":526},"cordis-european-research-council-award-640892","Novel enhancers of functional recovery after stroke","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","€147,968","Several forms of neuroadaptation are controlled by transient increases in the nuclear calcium concentration. Nuclear calcium regulates expression of crucial genes and alterations of this signaling network likely underlie many neurological disorders. Our work led us to design two innovative strategies exploiting the therapeutic potential of nuclear calcium signaling: 1-developing direct nuclear calcium signaling activators\u002Finhibitors (NCSA\u002FI) and 2-manipulating expression and\u002For function of nucle",{"id":528,"funder":7,"programme":8,"title":529,"piName":10,"institution":530,"country":12,"year":13,"amount":38,"abstract":531},"cordis-european-research-council-award-665775","Ratiometric FRET Based Nanosensors for Trypsin Related Human Recessive Diseases","FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA","The project aims to create a demo system for cost effective, non-invasive device for rapid detection of cystic fibrosis inhumans.The detection of human recessive diseases has been dominated by the use of fluorescent biomarkers, based on organicdyes, helping researchers to study and analyse gene expression, cell cycle, and enzymatic activity. Among severalproteolytic enzymes, trypsin has attracted much attention, as it is a target in the study of various important human recessivediseases includin",{"id":533,"funder":7,"programme":8,"title":534,"piName":10,"institution":217,"country":167,"year":13,"amount":38,"abstract":535},"cordis-european-research-council-award-655416","Ultra-sensitive Thermal Nanoscale Microscope","The research and commercialization of nanotechnology-based products require continuous development of advanced nanoscale inspection tools that drive the high-resolution microscopy markets. The state-of-the-art (SoA) microscopy provides a broad range of physical, spectroscopic, and materials characterization means, however, one of its key deficient ingredients is nanoscale thermal imaging – an essential tool for failure analysis and characterization of local heating and energy loss sources in hig",{"id":537,"funder":7,"programme":8,"title":538,"piName":10,"institution":217,"country":167,"year":13,"amount":38,"abstract":539},"cordis-european-research-council-award-640926","Precise and non-GMO Engineering of Nutritional Factors for Breeding High Quality Crops","While great attention has been given to increase nutritional substances in food plants only limited efforts have been made for using biotechnology to reduce the level of endogenous, anti-nutritional factors (e.g. toxic compounds) in existing crops. Anti-nutritional substances not only affect the digestion and absorption of nutrients, but can also be lethal to humans or feeding animals and are responsible for food spoilage. Glycoalkaloids (GLAs) produced by crops of the Solanacea family, namely, ",{"id":541,"funder":7,"programme":8,"title":542,"piName":10,"institution":543,"country":25,"year":13,"amount":10,"abstract":544},"cordis-european-research-council-award-665651","Hypermethylated DNA detection using NanoGaps","UNIVERSITEIT TWENTE","HYMEDNA prepares commercialization of very sensitive point-of-care biosensors for early-stage cancer detection based on the electrical detection of hypermethylated DNA (hmDNA) inside nanogaps.Only recently the awareness has risen that local hypermethylation of DNA provides a generic marker for a wide range of cancers. A robust, simple and cheap method for detecting hmDNA at low concentrations in blood, urine or faeces would be a major step forward in the early-stage detection of cancer. Existing",{"id":546,"funder":7,"programme":8,"title":547,"piName":10,"institution":543,"country":25,"year":13,"amount":38,"abstract":548},"cordis-european-research-council-award-641342","Explore the potentialities of biostealth coatings for tissue engineering and reconstructive medicine","BioStealth production of implant coatings provides an exciting business opportunity. BioStealth offers unique advantages of societal and economic importance, such as public health and sick leave. Biocompatible materials, i.e. materials with proper cell response upon implantation, are attractive for restoring body function. Conventional implant coating methods lack in quality and therefore the majority, if not all, bio-coatings fail in proper interaction with host tissue, either caused by absence",{"id":550,"funder":7,"programme":8,"title":551,"piName":10,"institution":147,"country":148,"year":13,"amount":38,"abstract":552},"cordis-european-research-council-award-640924","Forecasting and Monitoring Economic Indicators","Forecasting and monitoring key economic variables is one of the main activities of financial and government institutions, forecasting agencies, and investment companies. In the ERC-funded starting grant (ERC-2007-StG: Change-Point Tests) we developed novel models and tests for forecasting key economic indicators (such as economic activity, financial volatility and others) as well as evaluating the reliability of model predictions. In many cases our methods improve upon the current-state-of-art. ",{"id":554,"funder":7,"programme":8,"title":555,"piName":10,"institution":166,"country":167,"year":13,"amount":38,"abstract":556},"cordis-european-research-council-award-680600","An Antibody Microarray for Histone Modifications","Histones are the major structural proteins of eukaryotic DNA. Two copies each of the core histones, H2A, H2B, H3 and H4, form the core nucleosome, the basic unit of chromatin. Histone tails protrude from the nucleosome structure and are subject to a variety of post-translational modifications on multiple residues, including methylation, acetylation, phosphorylation, sumoylation, ubiquitination and polyribosylation. These histone modifications dictate local and global structure of chromatin, rend",{"id":558,"funder":7,"programme":8,"title":559,"piName":10,"institution":560,"country":12,"year":13,"amount":38,"abstract":561},"cordis-european-research-council-award-665671","Development of a more effective and safer therapeutic antibody for cancer treatment with a dual mechanism of action to eliminate CSCs and reactivate the tumour’s immune system.","FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO)","Global cancer market is growing at a CAGR of 6.9% with an estimated value of $81bn in 2016. Although the huge R&D investment observed in the past years in the development of new treatments, there is still lack on an effective treatment in many tumour types. In particular, the median survival for glioblastoma multiforme (GBM), a high-grade brain tumour affecting 23,000 patients a year in US and EU, is 14 months and its 5-yr survival less than 5%. It is therefore urgent to develop more effective t",{"id":563,"funder":7,"programme":8,"title":564,"piName":10,"institution":565,"country":58,"year":13,"amount":566,"abstract":567},"cordis-european-research-council-award-665725","Exploitation of Organic Electrochemical Transistors for Biological Ionsensing – Proof Of Concept","ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS","€149,673","The IONOSENSE-POC project proposes a novel solution to enable label-free, electronic monitoring of live cells in vitro, using innovative organic bioelectronic technology. The device, the organic electrochemical transistor (OECT), integrated with live cells forming a tissue, has been shown to accurately assess the integrity of the cells, providing dynamic, highly sensitive measurements after exposure to toxins\u002Fpathogens. Validation against traditional, optical methods, or commercially available e",{"id":569,"funder":7,"programme":8,"title":570,"piName":10,"institution":459,"country":25,"year":13,"amount":571,"abstract":572},"cordis-european-research-council-award-641000","Automated framework for rapid simulations of high-detail brain models","€149,937","Traditional methods of software modeling and simulation take prohibitive amounts of time to run for the size and complexity of biologically realistic neuron populations (e.g. >1 million). For instance, simulation of a 100 high-detail (Inferior-Olive) neuron-network for 10 minutes of brain time take 42 hours to complete on an modern PC workstation. To tackle this problem - common to the international neuroscience community -, we have turned to hardware-accelerated simulation platforms. We have em",{"id":574,"funder":7,"programme":8,"title":575,"piName":10,"institution":576,"country":65,"year":13,"amount":577,"abstract":578},"cordis-european-research-council-award-641322","A new process for the manufacture of methanol from waste glycerol","CARDIFF UNIVERSITY","€149,994","The idea is to bring to pre-commercial stage a highly effective, economically feasible catalyst for the conversion of glycerol (a waste product from the manufacture of biodiesel) to methanol developed under the ERC Advanced Grant – ‘After the Goldrush’ (ERC-2011-AdG-291319). ‘After the Goldrush’ is aimed at developing cheap alternatives to precious metal catalysts, particularly those containing gold and palladium that can be difficult to commercialise due to their high cost. During our initial s",{"id":580,"funder":7,"programme":8,"title":581,"piName":10,"institution":582,"country":82,"year":13,"amount":583,"abstract":584},"cordis-european-research-council-award-664713","DDRNA-based cancer therapy targeted telomeres","IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS","€149,425","The so-called “DNA damage response” (DDR) is a coordinated set of evolutionary-conserved events that, triggered upon DNA damage detection, arrests the cell-cycle and attempts DNA repair.  Recently, we have unveiled and reported that DDR activation depends on RNA. We observed that DNA double-strand  breaks (DSBs) trigger the local generation of small non-coding RNAs at the site of DNA damage carrying the sequence surrounding the damaged site. These DDR RNAs (DDRNAs) are essential for DDR activati",{"id":586,"funder":7,"programme":8,"title":587,"piName":10,"institution":132,"country":127,"year":13,"amount":38,"abstract":588},"cordis-european-research-council-award-641386","Minimal invasive x-ray source enabled by a novel vacuum packaging technique","In this project we aim to demonstrate and test a MEMS-based miniaturized electronic x-ray source enabled through a vacuum packaging concept developed under an ERC AdG. The source should be capable of delivering doses up to approximately 1 Gy\u002Fmin at a 2 mm distance while still having a millimetre overall size. This will be achieved by combining the vacuum packaging technique with a pointed field emission array developed in another project. The goal of the project is to demonstrate key functionali",{"id":590,"funder":7,"programme":8,"title":591,"piName":10,"institution":592,"country":593,"year":13,"amount":10,"abstract":594},"cordis-european-research-council-award-680896","Harvesting the Sun","KOBENHAVNS UNIVERSITET","DK","Biological production of high-value compounds such as medicines, flavors, fragrances and food ingredients, is predicted to constitute 50% of the World market by 2025 thus representing a commercial hotspot. A competitive edge for European industry within this domain is therefore important.  Today, 40% of prescribed medicinal drugs originate or are derived from rare or difficult to cultivate medicinal plants which typically contain the compounds in very low amounts and in complex mixtures. We have",{"id":596,"funder":7,"programme":8,"title":597,"piName":10,"institution":598,"country":12,"year":13,"amount":599,"abstract":600},"cordis-european-research-council-award-640696","Development of a ncRNA DNA Methylation Kit for the Diagnosis of Cancer of Unknown Primary","FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE","€149,278","The innovative idea behind the EPICUP (EPIgenetics of Cancer of Unknown Primary) project is to develop a package demonstrating the feasibility of a high-throughput tool for epigenotyping Cancer of Unknown Primary (CUP) to identify tumor type based in the DNA methylation profile of non-coding RNA (ncRNA) loci. CUPs are a heterogeneous group of cancers defined by the presence of metastatic disease with no identified primary tumor at presentation. In those CUPs where the primary tumor type is not i",{"id":602,"funder":7,"programme":8,"title":603,"piName":10,"institution":189,"country":12,"year":13,"amount":604,"abstract":605},"cordis-european-research-council-award-664926","ASESSMENT AND INITIAL STEPS FOR THE EXPLOITATION OF A SIMULATION SOFTWARE FOR THE STUDY AND MITIGATION OF THE EFFECT OF FLOODS ON CONSTRUCTIONS AND LANDSCAPE","€149,856","In the FLOODSAFE PoC we will explore the industrial applicability and potential for commercialization of the computational technology developed in the SAFECON Advanced Grant project for the study and mitigation of the effect of floods on constructions and landscape. The SAFECON technology will help engineers to the enhanced design, building and maintenance of new protective constructions under extreme floods, as well as for the surveillance, risk management and monitoring of existing constructio",{"id":607,"funder":7,"programme":8,"title":608,"piName":10,"institution":189,"country":12,"year":13,"amount":309,"abstract":609},"cordis-european-research-council-award-640957","On a free open source extreme scale finite element software","The ability of scientific computing to efficiently exploit forthcoming extreme scale machines will have a great impact in almost every field of science. The next generation of exascale computers is expected to reach billions of cores. As a result, high performance scientific software able to efficiently exploit these extreme scale super-computers is strategic in this scenario. However, this target is very challenging and requires ground-breaking advances in numerical algorithms. The free open so",{"id":611,"funder":7,"programme":8,"title":612,"piName":10,"institution":217,"country":167,"year":13,"amount":38,"abstract":613},"cordis-european-research-council-award-641182","Highly-lubricated soft contact lenses","The object of this proof of concept project is to modify soft contact lenses to render them more lubricated, and so make them far more comfortable to use. We propose to improve greatly the lubricity of soft contact lenses, used by over 100 million people worldwide with a market of around $7.5bn, and for which acute discomfort may arise from high friction at the interfaces between the lenses and the eyelid or cornea. According to an established clinical hypothesis, ocular comfort is related to th",{"id":615,"funder":7,"programme":8,"title":616,"piName":10,"institution":617,"country":65,"year":13,"amount":618,"abstract":619},"cordis-european-research-council-award-665751","Delivery of PULmonary Therapeutics through TARgetted Delivery using Phononics","UNIVERSITY OF GLASGOW","€149,791","According to the WHO 235 million people suffer from asthma and 64M people have chronic obstructive pulmonary disease, leading to 3M deaths per year worldwide. The cost of treating patients with all forms of lung disease is ~ €380B p.a., leading to the loss of >50M DALYS. Generally, patients with such respiratory diseases are treated by inhalation of medicines within aerosols, where the therapy (including medicine or biologics used in gene therapy) can be targeted directly to the lung. The accept",{"id":621,"funder":7,"programme":8,"title":622,"piName":10,"institution":623,"country":173,"year":13,"amount":38,"abstract":624},"cordis-european-research-council-award-640887","Low Temperature Ceramics Applications","OULUN YLIOPISTO","In this ERC PoC project, materials and methods developed in “Printed Electroceramics with Ultimate Compositions” will be utilised to demonstrate the feasibility of dielectric ultra-low temperature ceramics as basic electrical components realised on polymer, metal foil and paper substrates. The aims are to realise a set of capacitors and microwave antennae utilising high permittivity ceramic coatings as integral structures (without gluing, adhesives, etc. of discrete components) of aforementioned",{"id":626,"funder":7,"programme":8,"title":627,"piName":10,"institution":628,"country":629,"year":13,"amount":38,"abstract":630},"cordis-european-research-council-award-665770","CHIRALSENSE : Sensing Chirality using cavity-enhanced polarimetry: advances in sensitivity and time-resolution","IDRYMA TECHNOLOGIAS KAI EREVNAS","EL","Chiral sensing is crucial to many fields, constituting a multibillion Euro industry. The polarimetric techniques of optical rotation (OR) and circular dichroism (CD) are the most widely-used techniques for the analysis of chiral samples, ranging from the measurement of protein structure, to quality control in the pharmaceutical, chemical, cosmetic, and food industries. In general, the OR and CD signals are very small, which place severe constraints on detection sensitivity and time-resolution. T",{"id":632,"funder":7,"programme":8,"title":633,"piName":10,"institution":233,"country":25,"year":13,"amount":634,"abstract":635},"cordis-european-research-council-award-665522","Imaging with Photon Counting: Reduced costs, increased dynamic range","€147,500","Optical methods and fluorescent proteins to probe and manipulate cellular and subcellular processes have proven to be a major driving force behind many recent breakthroughs in biology and medicine. Recent developments in photonics have led to increased spatial and temporal resolution and now allow the study of single identified synaptic contacts between neurons as well as large-scale neuronal networks. Brain tissue strongly scatters light. Thereby, the amount of light emitted by fluorescent prob",{"id":637,"funder":7,"programme":8,"title":638,"piName":10,"institution":530,"country":12,"year":13,"amount":33,"abstract":639},"cordis-european-research-council-award-680900","Big Data for Catalysis","Catalysis is one of the scientific areas in which Europe has a leading position. The radical change in the use of rawmaterials from oil towards gas or biomass might compromise this position. Computational techniques have been identifiedas the third pillar in catalysis research and provide a great amount of data that can speed up the generation of new catalyticsystems through rational design. Industries are now starting to focus on the large amount of data published in the openliterature regardin",{"id":641,"funder":7,"programme":8,"title":642,"piName":10,"institution":643,"country":127,"year":13,"amount":644,"abstract":645},"cordis-european-research-council-award-637047","Validation of a conceptually new treatment for glioblastoma multiforme with an IP protected small molecule","KAROLINSKA INSTITUTET","€149,693","Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer with marginal life expectancy even with the most aggressive available therapy. We have identified a previously unanticipated vulnerability of GSCs which when targeted, leads to a rapid and complete cell death of all tumor cells isolated from nine different patients diagnosed with GBM. The cellular mechanism has been identified and involves an increased vulnerability of GSCs to massive vacuolization which can be induced by ",{"id":647,"funder":7,"programme":8,"title":648,"piName":10,"institution":649,"country":173,"year":13,"amount":10,"abstract":650},"cordis-european-research-council-award-640679","Novel solutions for assessing child cognitive function","TAMPEREEN KORKEAKOULUSAATIO SR","An important responsibility of primary health care in most societies is to conduct regular check-ups of children’s physical, cognitive, and social development, and to identify problems at an early stage to arrange for appropriate support and special care. Whereas well-validated methods exist for monitoring physical growth (e.g., WHO growth standards), there is a lack of standardized methods for monitoring other key aspects of early development (e.g., cognitive development). The present project e",{"id":652,"funder":7,"programme":8,"title":653,"piName":10,"institution":392,"country":12,"year":13,"amount":38,"abstract":654},"cordis-european-research-council-award-640921","COLOStage : A new prognosis test for the prediction of metastasis in Colorectal Cancer and Hepatocellular Carcinoma","ColoStage is a new prognostic test, based on a novel gene expression signature, able to predict robustly the risk of disease relapse after therapeutic intervention in colorectal cancer (CRC) and potentially in hepatocellular carcinoma (HCC).  We have previously demonstrated that CRC recurrence and metastasis strictly depend on high TGF-beta signaling (Calon et al., 2012). ColoStage is a gene expression signature that reflects the TGF-beta status of the primary tumor. Therefore, the expression of",{"id":656,"funder":7,"programme":8,"title":657,"piName":10,"institution":658,"country":629,"year":13,"amount":659,"abstract":660},"cordis-european-research-council-award-679345","Supplying lung adenocarcinoma cell lines to the cancer research community.","PANEPISTIMIO PATRON","€149,588","This project aims to protect, and commercialize a new panel of transplantable mouse lung cancer cell lines with defined mutation status (MLC) for cancer research and drug discovery. In addition, we aim at disseminating and exploiting a novel method for generating an unlimited pool of such lines from various strains of mice. Human lung cancer is characterized by a variety of mutations in oncogenes (i.e., KRAS) and tumor suppresors (i.e., TRP53), which largely determine whether lung tumors respond",{"id":662,"funder":7,"programme":8,"title":663,"piName":10,"institution":238,"country":32,"year":13,"amount":664,"abstract":665},"cordis-european-research-council-award-665607","Rapid and Inexpensive Diagnosis of Heparin Induced Thrombocytopenia Using Glycan Arrays Containing Synthetic Glycosaminoglycans","€147,094","Rapid and Inexpensive Diagnosis of Heparin Induced Thrombocytopenia Using Glycan Arrays Containing Synthetic GlycosaminoglycansHeparin, a complex glycosaminoglycan (GAG) carbohydrate, is the most commonly used anticoagulant. Twelve million patients in the EU are treated annually for conditions including acute coronary syndrome, deep-vein thrombosis and cardiopulmonary bypass surgery. Heparin-induced thrombocytopenia (HIT) is a dangerous adverse side effect of heparin administration. HIT-II devel",{"id":667,"funder":7,"programme":8,"title":668,"piName":10,"institution":669,"country":32,"year":13,"amount":670,"abstract":671},"cordis-european-research-council-award-662486","Morphogenetically active blood vessels: Proof-of-Concept","UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ","€149,962","Cardiovascular diseases are the leading causes of mortality in Europe and worldwide. Currently, synthetic prostheses used in bypass vascular surgery are produced from polyethylene terephthalate [PET] and expanded polytetrafluoroethylene [ePTFE]. Those materials show less than optimal, insufficient biocompatibility and durability properties, especially if used for SMALL DIAMETER BLOOD VESSELS. Within the frame of ERC Advanced Grant “BIOSILICA” (From gene to biomineral: Biosynthesis and applicatio",{"id":673,"funder":7,"programme":8,"title":674,"piName":10,"institution":675,"country":127,"year":13,"amount":676,"abstract":677},"cordis-european-research-council-award-680574","Digital readout of protein detection via super rolling circle amplification of DNA tags","UPPSALA UNIVERSITET","€149,375","This project will serve to evaluate market opportunities of a newly invented technology for digital detection of reporter DNAstrands in protein analysis.The purpose of my ongoing ERC project ProteinSeq is to develop technology and reagents for parallel, sensitive andspecific targeted protein analyses in plasma samples, lysates, etc. An important limiting factor for the broader adoption ofour technology is the cost and throughput of next generation sequencing and realtime PCR to read out the iden",{"id":679,"funder":7,"programme":8,"title":680,"piName":10,"institution":228,"country":167,"year":13,"amount":38,"abstract":681},"cordis-european-research-council-award-636335","A Non-Invasive Test for Guiding Follow–up of Patients with CT-Detected Lung Nodules","This PoC is a commercially-oriented spin-off from our “DIAG-CANCER” ERC project, addressing an urgent clinical need in the field of lung cancer (LC). The rationale behind this PoC is that CT-based LC screening programs are emerging in many countries worldwide. However, the high false positive rate of this technique (96% out of the 24% positive CT findings are non-cancerous) has been a major challenge in front those plans. This is because the CT-detected non-cancerous group has undergone unnecess",{"id":683,"funder":7,"programme":8,"title":684,"piName":10,"institution":685,"country":593,"year":13,"amount":686,"abstract":687},"cordis-european-research-council-award-641420","Terahertz wireless information systems and technologies","DANMARKS TEKNISKE UNIVERSITET","€146,400","This project aims to develop a proof-of-concept prototype of a wireless communication link based on ultra-high bit rate serial THz pulses. THz transmitters are known to be able to produce sub-picosecond pulses with frequency bandwidths in excess of several THz. In principle, this makes THz pulses able to carry Tbit\u002Fs data. This project will utilise these features of THz pulses and exploit them by amplitude modulating the THz pulses and stacking them closely together in time, thus creating a seri",{"id":689,"funder":7,"programme":8,"title":690,"piName":10,"institution":691,"country":32,"year":13,"amount":38,"abstract":692},"cordis-european-research-council-award-641036","Exploring the Potential for Therapeutic Lineage Reprogramming of Diabetes","MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)","Diabetes is a degenerative disease that affects over 350 million persons worldwide. Type 1 and type 2 diabetes are associated with either destruction or dysfunction of pancreatic insulin-producing β cells. Despite the availability of insulin as treatment to temporarily restore the glucostasis, this remedy is unable to avoid either the acute dangers of hypoglycemia or the long-term complications of hyperglycemia. Eventually, the challenge of treating diabetes centers on the replacement of pancrea",{"id":694,"funder":7,"programme":8,"title":695,"piName":10,"institution":696,"country":251,"year":13,"amount":38,"abstract":697},"cordis-european-research-council-award-680873","Advanced signal processing of time-domain data in mass spectrometry to leverage life sciences","SPECTROSWISS SARL","Advances in biotechnology, pharmaceutical and life sciences require improved performance of even the most powerful analytical techniques to target the extreme complexity of modern biological samples. Due to its high performance, Fourier transform mass spectrometry (FTMS) is the central analytical technique in biomolecular analysis. Fourier transform (FT) drives FTMS by converting the time-domain (transient) data to mass spectra which, in turn, provide the biological information. Although FT is r",{"id":699,"funder":7,"programme":8,"title":700,"piName":10,"institution":701,"country":167,"year":13,"amount":38,"abstract":702},"cordis-european-research-council-award-665055","Spatial super-resolution of electrophysiological measurements","TEL AVIV UNIVERSITY","Electroencephalography (EEG) is the non-invasive recording of electrical brain activity, and is an indispensable diagnostic and research tool. A significant advantage of EEG compared to other brain imaging modalities is its high temporal resolution. The downside of EEG is, however, its poor spatial resolution, which is one of the reasons for its gradual replacement by costlier alternatives. It results mainly from the sharp discontinuity in the electric conductivity of the skull bones acting as a",{"id":704,"funder":7,"programme":8,"title":705,"piName":10,"institution":706,"country":707,"year":13,"amount":38,"abstract":708},"cordis-european-research-council-award-680912","Practical Approximation Algorithms - Proof of Concept","UNIWERSYTET WARSZAWSKI","PL","Nowadays, we witness that more and more information is stored and managed in a digital way. Moreover, very often processes are executed and planed by computers. This allows applying computer methods to optimize performance of our actions on an unprecedented scale. This is clearly visible in the case of eCommerce, where the main arena of operation of companies is handled solely using computers. Typically, machine learning tools and algorithms are widely used, e.g., for the prediction of user beha",{"id":710,"funder":7,"programme":8,"title":711,"piName":10,"institution":222,"country":65,"year":13,"amount":14,"abstract":712},"cordis-european-research-council-award-665631","Prognosis and Diagnosis of Protein Misfolding Diseases by Seeded Aggregation in Microspheres","There is currently no early detection system for neurological protein misfolding disorders (such as Alzheimer's and Parkinson's diseases) that would satisfy the demands for rapid, quantitative, flexible, and reproducible assays to study amyloidogenesis in biological samples. We will explore the potential of aggregation assays in microdroplets that are formed in microfluidic devices. We have found that the readout of this assay reflects the disease progression, when samples of Drosophila fruit fl",{"id":714,"funder":7,"programme":8,"title":715,"piName":10,"institution":228,"country":167,"year":13,"amount":38,"abstract":716},"cordis-european-research-council-award-641171","Simultaneous three dimensional multiphoton microscopy without mechanical depth scanning","Information in the nervous system is typically represented in activity patterns distributed across large populations of neurons in three dimensions, and there is a lot of current interest in the development of systems that can volumetrically image these patterns (or other distributed processes) in real-time. During our work towards imaging responses to artificial retinal stimulation we have developed a solution for remotely manipulating the illumination plane during temporal-focusing multiphoton",{"id":718,"funder":7,"programme":8,"title":719,"piName":10,"institution":272,"country":65,"year":13,"amount":720,"abstract":721},"cordis-european-research-council-award-693297","ExoData: a commercially supported space telescope","€139,454","ExoData will use results from the very successfull ExoMol Advanced Award which created comprehensive spectroscopic line lists to help understand and model the atmospheres of exoplanets. ExoData will help build and fund a satellite aimed at characterising exoplanet atmospheres using a cheap, agile, low earth orbit satellite mission with a launch date this decade. This mission will be part funded bythe sale of telescope data to interested international clients. This is a new business model for ast",{"id":723,"funder":7,"programme":8,"title":724,"piName":10,"institution":725,"country":726,"year":13,"amount":38,"abstract":727},"cordis-european-research-council-award-641093","Developing Novel and Optimal Additive Solutions for Red Blood Cells","HASKOLI ISLANDS","IS","The research conducted in SYSTEM_US (ERC Advanced Grant #232816) has ledto the discovery of valuable biomarkers for the quality of red blood cells (RBCs)in standard blood bank storage conditions. Using a combination of systemsbiology and metabolomics, this discovery will lead to the development of novelRBC storage technologies including additive solutions and diagnostics. Thesetechnologies will become valuable assets in the form of intellectual property tolarge transfusion medicine companies and",{"id":729,"funder":7,"programme":8,"title":730,"piName":10,"institution":731,"country":32,"year":13,"amount":10,"abstract":732},"cordis-european-research-council-award-680883","Voice Emotion detection by Appraisal Inference","AUDEERING GMBH","The automated sensing of human emotions has gained a lot of commercial attention lately. For facial and physiological sensing many companies offer first professional products. Recently, voice analytics has become a hot topic, too, with first companies emerging for the telecom, entertainment, and robot markets (e.g. Sympalog, Aldebaran, etc.). Current vocal emotion detection approaches rely on machine learning where emotions are identified based on a reference set of expression clips. The drawbac",{"id":734,"funder":7,"programme":8,"title":735,"piName":10,"institution":228,"country":167,"year":13,"amount":634,"abstract":736},"cordis-european-research-council-award-640579","A new reconstructing technique using tissue engineering methods to create an engineered autologous vascularized  tissue flap","Abdominal wall defects are often the consequence of severe trauma, cancer treatment and burns. These defects involve a significant loss of tissue, and often require surgical reconstruction where tissue is lifted from the patient's donor site and moved to his injured site with an intact blood supply (autologous muscle free flap). The current transfer surgery is complicated and involved with donor-site morbidity after tissue harvesting, and scant availability. We propose a robust engineered transp",{"id":738,"funder":7,"programme":8,"title":739,"piName":10,"institution":250,"country":251,"year":13,"amount":38,"abstract":740},"cordis-european-research-council-award-665756","Mobile 3D Modeling","The topic of this proposal is mobile 3D modeling.  Building on top of 4DVideo results published at the latest International Conference on Computer Vision (ICCV2013), the goal of this proposal is to explore the commercial potential of enabling mobile 3D scanning with smart phones.  Our algorithms allow to perform accurate 3D modeling from images at interactive rates on a smart phone (without requiring any additional sensors or a live data connection).  Our solution can greatly expand the range of",{"id":742,"funder":7,"programme":8,"title":743,"piName":10,"institution":217,"country":167,"year":13,"amount":38,"abstract":744},"cordis-european-research-council-award-641389","Sequence-Enabled Single cEll Identification device","The dynamics of cell populations within tissues and organs is a hallmark of multi-cellular organisms. In many pathological states (e.g. cancer, diabetes etc) the functions and quantities of specific cell populations change. The ability to simultaneously and effectively monitor these functions and changes is essential for the study of these pathologies and the development of diagnostics and treatment. While single cell profiling is a multi billion dollar market, currently, unbiased and comprehens",{"id":746,"funder":7,"programme":8,"title":747,"piName":10,"institution":530,"country":12,"year":13,"amount":38,"abstract":748},"cordis-european-research-council-award-664719","A Solar-Powered Hydrolyzer","We aim to determine the technical and economic viability of a novel water electrolyzer technology based in inexpensive catalysts from transition metal coordination polymers. Industrial water electrolyzers currently need the use of corrosive alkaline electrolytes or expensive noble-metal catalysts to reach reasonable efficiencies. Because of this, they cannot compete with low cost hydrogen production using fossil fuels through steam reforming. We have discovered that coordination polymers of eart",142,{"programme":8,"total":751,"withPiName":752,"firstYear":753,"lastYear":754,"countryCount":755,"perYear":756,"topInstitutions":794,"topCountries":862},2347,7,2014,2027,31,[757,759,760,762,765,768,771,774,777,780,783,786,789,792],{"year":753,"count":758},13,{"year":13,"count":749},{"year":761,"count":749},2016,{"year":763,"count":764},2017,200,{"year":766,"count":767},2018,160,{"year":769,"count":770},2019,176,{"year":772,"count":773},2020,174,{"year":775,"count":776},2021,120,{"year":778,"count":779},2022,198,{"year":781,"count":782},2023,231,{"year":784,"count":785},2024,237,{"year":787,"count":788},2025,265,{"year":790,"count":791},2026,264,{"year":754,"count":793},25,[795,798,801,804,807,810,813,816,819,821,823,826,829,832,834,837,840,842,845,847,849,851,854,857,859],{"name":796,"count":797},"Centre National de la Recherche Scientifique CNRS",84,{"name":799,"count":800},"Weizmann Institute of Science",65,{"name":802,"count":803},"Technion - Israel Institute of Technology",43,{"name":805,"count":806},"The Chancellor Masters and Scholars of the University of Cambridge",42,{"name":808,"count":809},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",41,{"name":811,"count":812},"Fondazione Istituto Italiano di Tecnologia",34,{"name":814,"count":815},"Tel Aviv University",33,{"name":817,"count":818},"Imperial College of Science Technology and Medicine",32,{"name":820,"count":818},"Politecnico di Milano",{"name":822,"count":755},"Institut National de la Sante Et de la Recherche Medicale",{"name":824,"count":825},"Ecole Polytechnique Federale de Lausanne",30,{"name":827,"count":828},"Universiteit Twente",29,{"name":830,"count":831},"The Hebrew University of Jerusalem",28,{"name":833,"count":831},"Universiteit Gent",{"name":835,"count":836},"The Chancellor, Masters and Scholars of the University of Oxford",27,{"name":838,"count":839},"Danmarks Tekniske Universitet",24,{"name":841,"count":839},"Vib Vzw",{"name":843,"count":844},"Katholieke Universiteit Leuven",23,{"name":846,"count":844},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",{"name":848,"count":844},"Technische Universitaet Muenchen",{"name":850,"count":844},"Technische Universiteit Delft",{"name":852,"count":853},"The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undivided Trinity of Queen Elizabeth Near Dublin",22,{"name":855,"count":856},"Technische Universiteit Eindhoven",21,{"name":858,"count":856},"Universiteit Leiden",{"name":860,"count":861},"Eidgenoessische Technische Hochschule Zuerich",20,[863,865,867,869,871,873,875,877,879,881,883,886,888,890,892,895,896,898,900,902,905,908,910,912,915],{"name":32,"count":864},299,{"name":12,"count":866},273,{"name":65,"count":868},261,{"name":25,"count":870},254,{"name":82,"count":872},221,{"name":58,"count":874},215,{"name":167,"count":876},191,{"name":154,"count":878},109,{"name":251,"count":880},85,{"name":127,"count":882},72,{"name":884,"count":885},"AT",62,{"name":593,"count":887},50,{"name":261,"count":889},48,{"name":173,"count":891},47,{"name":893,"count":894},"PT",40,{"name":629,"count":861},{"name":320,"count":897},19,{"name":408,"count":899},17,{"name":148,"count":901},12,{"name":903,"count":904},"CZ",11,{"name":906,"count":907},"LU",10,{"name":707,"count":909},8,{"name":911,"count":909},"SI",{"name":913,"count":914},"HU",5,{"name":916,"count":917},"HR",2]