[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-proof-of-concept-2017":3,"awarded-stats-erc-proof-of-concept":1036},{"awarded":4,"total":1035},[5,16,23,27,33,38,42,48,55,60,65,70,76,82,86,91,98,104,109,114,120,124,130,135,140,145,151,156,163,168,174,180,186,191,197,203,210,215,221,227,233,238,244,250,256,261,267,272,277,282,287,292,297,303,307,313,319,325,331,337,342,348,352,356,361,367,371,375,379,384,390,394,399,404,409,415,421,426,430,434,439,444,450,454,459,463,468,473,479,483,489,494,499,505,510,514,519,524,529,533,537,542,547,552,556,561,565,570,576,581,587,592,598,604,610,615,621,627,633,639,643,649,653,657,661,666,671,676,681,687,691,697,702,706,711,717,722,727,731,735,739,743,749,754,758,762,767,771,776,782,787,793,799,804,810,815,820,825,829,833,839,845,851,857,862,867,872,878,883,887,891,896,901,907,911,917,921,926,930,934,940,945,950,954,959,964,968,973,977,983,987,992,996,1002,1007,1012,1018,1022,1026,1031],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-727283","European Research Council","ERC Proof of Concept","An Artificial Visual Cortex for Image Processing",null,"CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","FR",2017,"€149,937","The ERC starting grant GECOMETHODS, on which this POC is based, tackled problems of diffusion equations via geometric control methods. One of the most striking achievements of the project has been the development of an algorithm of image reconstruction based mainly on non-isotropic diffusion. This algorithm is bio-mimetic in the sense that it replicates the way in which the primary visual cortex V1 of mammals processes the signals arriving from the eyes. It has performances that are at the state",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":20,"year":13,"amount":21,"abstract":22},"cordis-european-research-council-award-727595","A Mnemonic system based on stimulation-free Neuroimaging","UNIVERSIDAD POMPEU FABRA","ES","€150,000","This project’s aim is the commercialization of a neurotechnology device, MNeuronic, that helps its users to improve their memory retention. MNeuronic can be used in cognitive rehabilitation on patients with mild to moderate decline in memory function as well as by healthy users, as a cognitive training method at home. The system will be mounted on wearable, relatively affordable hardware. Its core technology is grounded on principles and ideas developed in my current ERC-StG project on attention",{"id":24,"funder":7,"programme":8,"title":25,"piName":10,"institution":19,"country":20,"year":13,"amount":21,"abstract":26},"cordis-european-research-council-award-768530","Technologies for Supporting Online Music Education","Online learning has impacted and changed music education significantly all over the world in the last decade. Music schools and teachers have now access to a much wider audience, increasing their business opportunities specially by overcoming the geographical constraints. However, online music performance education cannot scale to MOOC level given that the student assessments rely on individual instructor review, as is the case in the well known online courses from Berklee Online. The need of a ",{"id":28,"funder":7,"programme":8,"title":29,"piName":10,"institution":30,"country":31,"year":13,"amount":21,"abstract":32},"cordis-european-research-council-award-768929","CellPrintArray – on-demand nano-scale printing of live cells and compounds for miniaturized cell screening applications","KARLSRUHER INSTITUT FUER TECHNOLOGIE","DE","The goal of this ERC-PoC project is to develop a prototype system that will enable the addition of libraries of drugs and biochemical molecules, reagents and cells from a 96 source plate directly to individual compartments of the target Droplet Microarray (DMA). The system should have controlled atmosphere (CO2, humidity, temperature) and should allow for dispensing controlled volumes (3-500 nL per experiment) and cell numbers (1-100 per experiment) into individual droplets. We aim to create and",{"id":34,"funder":7,"programme":8,"title":35,"piName":10,"institution":30,"country":31,"year":13,"amount":36,"abstract":37},"cordis-european-research-council-award-755380","Silicon-Organic Hybrid Transceivers for Terabit\u002Fs Data Network","€149,875","Megatrends such as the Internet of Things (IoT), Industry-4.0 paradigms, and cloud-based service delivery are combining to push data-center infrastructures to their limits. This applies in particular to Ethernet-based communication networks within large data centers, which limit further scalability of computing power and storage capacity already today. Compact power-efficient transceiver concepts are key to overcome these bottlenecks.SCOOTER aims at what the Ethernet Alliance has recently classi",{"id":39,"funder":7,"programme":8,"title":40,"piName":10,"institution":30,"country":31,"year":13,"amount":21,"abstract":41},"cordis-european-research-council-award-741728","A custom lock chip for compact NMR","Nuclear magnetic resonance is an important chemical analysis method, because of its inherent chemical specificity, its versatility to extract molecular information, and its absolute accuracy. The market has been dominated by large superconducting NMR magnets with price tags of many 100k €. The emergence of less expensive low field compact (tabletop and portable) NMR spectrometers, based on the use of permanent magnets, with price tags around a factor of 10 lower than superconducting magnets, bri",{"id":43,"funder":7,"programme":8,"title":44,"piName":10,"institution":45,"country":20,"year":13,"amount":46,"abstract":47},"cordis-european-research-council-award-754609","A Photothermal Lateral Flow Test for Visual Point of Care Detection","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","€149,293","The rapid development of cost-effective and efficient biosensors has had a profound worldwide socioeconomic impact. Advances in the fields of microelectronics, materials science and nanotechnology have been vital to the implementation of enhanced sensing platforms aimed at providing alternatives to traditional analytical methods. Further, current sensing platforms are often slow, unreliable and expensive; in particular, when ultralow concentration detection is required. Although progress in the ",{"id":49,"funder":7,"programme":8,"title":50,"piName":10,"institution":51,"country":52,"year":13,"amount":53,"abstract":54},"cordis-european-research-council-award-754748","Implementing Special Nanomaterials in Ultra-performance Mobile Radomes","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","UK","€149,811","OxfordNano aims to enhance the EU manufacturing capability in aerospace composite structures using special nanomaterials (NMs) technology derived from ERC research. The target application for this capability is ultra-performance radomes for airborne sensors systems and a growing opportunity to deliver digital services to users on the move e.g. passengers in civil aircraft and trains.Mobile radomes for the aviation industries need to be strong in structure and impact, lightweight and easily forme",{"id":56,"funder":7,"programme":8,"title":57,"piName":10,"institution":51,"country":52,"year":13,"amount":58,"abstract":59},"cordis-european-research-council-award-767454","BOTFIND:  Finding Bots, Detect Harassing Automation, and Restoring Trust in Social Media Civic Engagement","€149,921","Social media platforms have become tools for manipulating public opinion during elections. In particular, “bots” are algorithms that automate rapid, widespread interactions with citizens, often with deleterious effects on public knowledge of science, social inequality, and public policy options. Through the ERC COMPROP Consolidator award, researchers have demonstrated that even simple bots (i) effectively keep negative messages and fake news in circulation longer (ii) target journalists and civi",{"id":61,"funder":7,"programme":8,"title":62,"piName":10,"institution":51,"country":52,"year":13,"amount":63,"abstract":64},"cordis-european-research-council-award-737476","CAPITA: Child Abuse Prevention International Training and Access","€149,159","This Proof of Concept proposal is a rare opportunity to translate social program innovation into international impact. Every year, a billion children worldwide are victims of child abuse. The highest rates are in  low-and-middle-income countries, affecting children of all ages (WHO, 2012). A small number of child abuse prevention programs for young children have been tested in high-income countries and commercialized. This makes them inaccessible to the vast majority of families at risk of abuse",{"id":66,"funder":7,"programme":8,"title":67,"piName":10,"institution":45,"country":20,"year":13,"amount":68,"abstract":69},"cordis-european-research-council-award-737620","Multiparametric probe for monitoring in real time environmental variables in drilling boreholes","€147,753","The idea that is presented is the commercialization of a multiparametric probe for monitoring in real time environmental variables in drilling boreholes which was designed and tested during the development of the ERC project IPBSL 250350 and able to perform in hostile environments (acidic pH, high concentration of oxidants, high pressure). The main difference between our prototype and the already existing commercial multiparametric probes is the number of measurable parameters, its control and t",{"id":71,"funder":7,"programme":8,"title":72,"piName":10,"institution":73,"country":74,"year":13,"amount":10,"abstract":75},"cordis-european-research-council-award-780061","Luminescent silicon nanocrystals as bioimaging systems","ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA","IT","Optical imaging is a powerful tool for light-guided surgery and for the study of biological functions via dynamic visualization of processes in tissues and cells. Most of optical imaging techniques utilise fluorescent probes that can suffer from low contrast, due to scattering of the excitation light, and low tissue penetration. Silicon nanocrystals (SiNCs), developed within the ERC PhotoSi project, are a very promising alternative for this purpose: silicon is essentially non-toxic, easily avail",{"id":77,"funder":7,"programme":8,"title":78,"piName":10,"institution":79,"country":12,"year":13,"amount":80,"abstract":81},"cordis-european-research-council-award-737560","Development of high-resolution, high-throughput microscopy","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","€149,788","Current 3D microscopy methods are limited in speed due to the need to scan the sample in the optical axis. Multifocus microscopy - or MFM- is a method that allows for the instant acquisition of a 3D volume without scanning, thus increasing acquisition speed by a factor of 10-100. MFM based on diffractive optics allows for easy optimization of the total volume acquired and the sampling rate. In our ERC-StG project, we developed an important expertise in the design and construction of diffractive ",{"id":83,"funder":7,"programme":8,"title":84,"piName":10,"institution":79,"country":12,"year":13,"amount":21,"abstract":85},"cordis-european-research-council-award-755460","Treatment of liver disease and cancer prevention","Advanced liver disease and cancer is the only major cause of death still increasing each year. Major causes include hepatitis B and C viruses, alcohol and non-alcoholic fatty liver disease\u002Fsteatohepatitis (NAFLD\u002FNASH). A major contributing factor to the increasing incidence and mortality of liver disease is the staggering rise in obesity. The absence of effective therapeutic options for NAFLD\u002FNASH, advanced liver disease and cancer contribute to the poor prognosis and the high cost associated wi",{"id":87,"funder":7,"programme":8,"title":88,"piName":10,"institution":89,"country":74,"year":13,"amount":21,"abstract":90},"cordis-european-research-council-award-780333","A holographic microscope for the immersive exploration of augmented micro-reality","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","Virtual reality, augmented reality and mixed reality are beginning to transform the way we explore and acquire information from the macroscopic world around us. At the same time, recent advances in holographic microscopy are providing new tools for the 3D imaging of physical and biological phenomena occurring at the micron scale. Project ADMIRE will combine this two emerging technologies into the first prototype of an AugmenteD MIcro-REality system for the immersive exploration and the quantitat",{"id":92,"funder":7,"programme":8,"title":93,"piName":10,"institution":94,"country":95,"year":13,"amount":96,"abstract":97},"cordis-european-research-council-award-767176","Ultrafast charge density wave memory for quantum computing","INSTITUT JOZEF STEFAN","SI","€149,452","The goal of the PoC is to take a newly discovered phenomenon in quantum electronic materials into a potentially disruptive memory technology offering unprecedented high speed, low energy consumption combined with low temperature operation. With the PoC grant we aim to establish (i) viability of such memory devices within the scope of ultrafast low-temperature quantum computing and clarify the most important outstanding technical issues for implementation (ii) generate a business plan and asses t",{"id":99,"funder":7,"programme":8,"title":100,"piName":10,"institution":101,"country":31,"year":13,"amount":102,"abstract":103},"cordis-european-research-council-award-737537","A Compact and Automated Liquid Handling Platform for Biomedical Assays","TECHNISCHE UNIVERSITAET MUENCHEN","€149,750","Liquid handling is an integral part of biological and medical assays. For many applications the method of choice is manual pipetting, which has significant limitations. Chiefly, it is user-time intensive and prone to sample handling issues (poor time accuracy and pipetting errors). While liquid handling robots do exist, they are expensive instruments, shared by many users and targeted for high-throughput applications. This leaves, in practice, most research and diagnostics without an automated s",{"id":105,"funder":7,"programme":8,"title":106,"piName":10,"institution":101,"country":31,"year":13,"amount":107,"abstract":108},"cordis-european-research-council-award-727611","Improved Communication of High Impact Weather Events","€148,750","In the scope of my ERC Advanced Grant “SaferVis, I have focused especially on the development of novel concepts and algorithms for analysing the uncertainty that is represented by an ensemble of simulations of a physical phenomenon, such as ensemble weather forecasts. Instead of making a single deterministic computation of the future weather state, today the weather centres worldwide compute ensembles of numerical forecasts routinely using operational ensemble prediction systems. Weather forecas",{"id":110,"funder":7,"programme":8,"title":111,"piName":10,"institution":112,"country":20,"year":13,"amount":21,"abstract":113},"cordis-european-research-council-award-737543","Image Analysis Online Services for in-vitro experiments","UNIVERSIDAD DE ZARAGOZA","Image analysis has become a powerful tool in multiple biomedical applications, ranging from clinical cases to cellular experiments. The main purpose of IMAGO is to extract relevant information from image-based analysis to perform comparative studies in 3D cell cultures. Most of the cell-based experiments have been performed in 2D, but 3D conditions are biologically more relevant. IMAGO presents the development of a tool for image analysis focused on, but not limited to, the quantification of cel",{"id":115,"funder":7,"programme":8,"title":116,"piName":10,"institution":117,"country":74,"year":13,"amount":118,"abstract":119},"cordis-european-research-council-award-780757","Electro-optical polariton router","CONSIGLIO NAZIONALE DELLE RICERCHE","€149,406","In this proposal we plan to bring to a development stage TRL 3 an electro-optical device working at room temperature and based on polaritons (an hybrid photon-exciton particle) made of 2D perovskites and of an optical surface mode in a Distributed Bragg Reflector waveguide. Such a device could lead to extremely compact and ultrafast electro-optical modulators that can be fully integrated in a microchip to allow for fast signal communications between each peripheral component of a processor. As a",{"id":121,"funder":7,"programme":8,"title":122,"piName":10,"institution":30,"country":31,"year":13,"amount":36,"abstract":123},"cordis-european-research-council-award-766695","Scanner for novel chemical reactions","Funded by the ERC-Starting Grant COMBIPATTERNING, we have developed a novel nanolayer-based synthesis based on patterning different materials with laser radiation in form of a pan-cake spots in array format. Our synthesis robot can do it for many different materials, for >40.000 spots per glass slide, in exactly defined stoichiometries, and for \u003C200 € costs. The robot uses short laser pulses to transfer \u003C1ng “punched-out” material per spot from a donor foil to a synthesis slide. Then, the reacta",{"id":125,"funder":7,"programme":8,"title":126,"piName":10,"institution":127,"country":52,"year":13,"amount":128,"abstract":129},"cordis-european-research-council-award-737569","Networking and Care: Helping young people with mental health problems through outreach and eHealth","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","€149,973","The aim of this project is to develop a mobile app which facilitates access to mental health services and treatments for young people with mental health problems; and to assess its feasibility, acceptability and potential clinical and cost-effectiveness. If successful, the app would: (1) increase access to mental health care by providing links to relevant existing services; (2) increase access to relevant evidence-based mobile health interventions and to address barriers to care and (3) allow in",{"id":131,"funder":7,"programme":8,"title":132,"piName":10,"institution":11,"country":12,"year":13,"amount":133,"abstract":134},"cordis-european-research-council-award-780519","Innovative testing of microRNA from liquid biopsies using bistable molecular circuits","€149,852","We are designing molecular networks - based on DNA programing- to detect extremely dilute molecular signals and robustly separate them from background noise. This could have relevant applications in the field of molecular diagnostics, in particular in the area of ultra-sensitive testing of nucleic acids from liquid biopsy for example for the detection of circulating microRNA. MicroRNA are difficult targets for standard ultra sensitive techniques such as quantitative PCR, but, because of their pr",{"id":136,"funder":7,"programme":8,"title":137,"piName":10,"institution":138,"country":12,"year":13,"amount":21,"abstract":139},"cordis-european-research-council-award-780383","Innovative Antibiotics to target drug-resistant microbes","INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT","Antibiotic resistance has become a major public health threat in Europe and the United States where resistant bacteria are directly responsible for ten of thousands deaths per year. The D_Bug project aims to develop innovative antibiotics to target drug-resistant microbes.",{"id":141,"funder":7,"programme":8,"title":142,"piName":10,"institution":143,"country":31,"year":13,"amount":21,"abstract":144},"cordis-european-research-council-award-727575","NMR-based Sensor Technology at Nanoscale","UNIVERSITY OF STUTTGART","Nuclear Magnetic Resonance (NMR) spectrometry is the most widely used method in the spectrometry market. With applications in various areas such as geo exploration, material quality control, drug development, and biomedical imaging, NMR provides rich spectroscopic information of the structure for material analyses. Therefore, for advancing human health and science, NMR spectrometry and also microfluidics are widely adopted technologies in studying biological processes and thus utilised in many b",{"id":146,"funder":7,"programme":8,"title":147,"piName":10,"institution":148,"country":12,"year":13,"amount":149,"abstract":150},"cordis-european-research-council-award-755235","A Traffic Management Optimization platform for enhanced road network efficiency","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","€149,903","Building on the advances of the ERC TRAM3 project, the TramOpt PoC project aims are twofold:1) developing a robust prototype to allow real-life testing and deployment of a novel vehicular traffic control Decision Support System (DSS) based on a software platform for road traffic management including variable speed limits, ramp-metering and re-routing policies. This DSS is intended for public and private traffic managers to increase freeway network performances (e.g. congestion and pollution redu",{"id":152,"funder":7,"programme":8,"title":153,"piName":10,"institution":154,"country":52,"year":13,"amount":149,"abstract":155},"cordis-european-research-council-award-737576","Design of a new non-existing layer of information delivery through smell","THE UNIVERSITY OF SUSSEX","The idea for this proposal is to demonstrate the design of olfactory widgets (OWidgets) as a proof-of-concept implementation based on the semantic integration of smell to convey specific information to the user. We will showcase the meaningful design of OWidgets in two distinct markets. Widgets are well established as simple application extensions, integrated in a larger application and usually pre-installed on a device. Widgets allow quick access to information without requiring a user to open ",{"id":157,"funder":7,"programme":8,"title":158,"piName":10,"institution":159,"country":160,"year":13,"amount":161,"abstract":162},"cordis-european-research-council-award-768731","Antibiofouling Nanopatterned Electrospun Membranes for Nanofiltration Applications","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","IE","€148,805","Water-stress in an increasing global problem and solutions such as water recycling and seawater desalination are nowbecoming a necessary part of the water infrastructure. The technology for the production of safe drinking is increasinglydependent on these more diverse sources and a key enabling technology is membrane filtration. While membrane systemare effective, the operating costs of such systems are hampered by fouling which increases the energy requirement forprocess operation. The unique i",{"id":164,"funder":7,"programme":8,"title":165,"piName":10,"institution":166,"country":20,"year":13,"amount":21,"abstract":167},"cordis-european-research-council-award-755027","Application of genomic inversions as diagnostic markers in precision medicine","UNIVERSITAT AUTONOMA DE BARCELONA","Despite the initial high expectations of genome variation studies, only a small proportion of the genetic risk of common and complex diseases has been identified so far. Most of the work has focused on single nucleotide polymorphisms (SNPs) and copy number variants (CNVs). Inversions, on the other hand, are a type of structural variant that affects a large fraction of the human genome and is implicated in phenotypic differences in diverse organisms. However, they have been poorly studied because",{"id":169,"funder":7,"programme":8,"title":170,"piName":10,"institution":171,"country":172,"year":13,"amount":21,"abstract":173},"cordis-european-research-council-award-727579","Programming with Big Code","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","IL","Software synthesis aims to automate the creation of software by generating parts of software from a higher-level description. Until recently it was believed to be impossible to practically synthesize software beyond very small fragments. However, synthesis based on learning from existing large code-bases (“Big Code”) is making synthesis into a practical reality . The purpose of this PoC is to develop a platform that would lead to commercialization of our technology to improve programming product",{"id":175,"funder":7,"programme":8,"title":176,"piName":10,"institution":177,"country":178,"year":13,"amount":36,"abstract":179},"cordis-european-research-council-award-768826","Super-resolution genomic mapping for the microbiome","KATHOLIEKE UNIVERSITEIT LEUVEN","BE","Animals and bacteria have been working together for about as long as they have co-existed, long before the advent of mankind. The bodies of our ancient ancestors offered protected, nutrient-rich habitats for bacteria. In return, animals could take an evolutionary short-cut to developing new capabilities by ‘borrowing’ bacterial genes. Indeed, when gut bacteria assist with the digestion of e.g. dietary fiber, the resulting metabolites will subsequently exert an influence on an intricate network o",{"id":181,"funder":7,"programme":8,"title":182,"piName":10,"institution":183,"country":52,"year":13,"amount":184,"abstract":185},"cordis-european-research-council-award-754654","A Software Interface for Interactive Ensemble-Based Drug Design","THE UNIVERSITY OF EDINBURGH","€149,951","The ERC project EBDD was funded to bring about a new generation of computer algorithms to implement accurate molecular simulations of biomolecules and their interactions with man-made molecules that are potential new therapeutics.  First results from the EBDD project (ERC-StG-2013-336289) indicate the ground-breaking potential of the academic software generated for supporting pre-clinical drug discovery R&D in the pharmaceutical and biotech sectors. Building on these early results from the EBDD ",{"id":187,"funder":7,"programme":8,"title":188,"piName":10,"institution":189,"country":20,"year":13,"amount":21,"abstract":190},"cordis-european-research-council-award-737558","FAST and accurate Testing of Organic Materials","ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN NANOCIENCIAS CIC NANOGUNE","Organic electronic devices are currently ubiquitous. For example, most mobile phones in the market have screens based on organic light-emitting diodes. These devices have many advantages against their inorganic counterparts, as they have for example lower manufacturing costs, they are typically very light and robust and can built into flexible devices, bendable and foldable. Organic chemists are constantly producing new organic materials which could outperform the ones used commercially and henc",{"id":192,"funder":7,"programme":8,"title":193,"piName":10,"institution":194,"country":195,"year":13,"amount":21,"abstract":196},"cordis-european-research-council-award-693184","Cerebral organoids: human mini brains in a dish open up new possibilities for drug development in neurodegenerative and developmental diseases","INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH","AT","Transferring results from animal models to humans is a major bottleneck in pharmaceutical research. This is particularly true for brain disorders, including neurodegenerative and developmental diseases. Both animal models and conventional cell culture methods fail to recapitulate the complexity of the human brain and there are fundamental differences in developmental and physiological aspects between humans and the commonly used animal models. The high attrition rate of drugs for brain disorders",{"id":198,"funder":7,"programme":8,"title":199,"piName":10,"institution":200,"country":31,"year":13,"amount":201,"abstract":202},"cordis-european-research-council-award-755369","Hide and Seek with Cancer Drugs","ALBERT-LUDWIGS-UNIVERSITAET FREIBURG","€149,981","Cancer is one of the most prominent causes for morbidity and mortality in industrialized countries. The key challenge in drug-based anti-cancer therapy is to efficiently kill the cancer cells while minimizing side-effects on healthy parts of the body. The DeShield project will establish the proof of concept for a novel approach to upgrade existing anti-cancer drugs in a way that the anti-cancer effect will be increased while side-effects will simultaneously minimized. DeShield technology will be",{"id":204,"funder":7,"programme":8,"title":205,"piName":10,"institution":206,"country":207,"year":13,"amount":208,"abstract":209},"cordis-european-research-council-award-737600","Pharmacological safety testing in human adult stem cell-derived organoids","KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW","NL","€147,500","Toxicology and pharmacology assays are crucial pillars of modern drug development. They are essential to understand how tissues such as intestine and liver take up and degrade pharmaceutically active compounds. Due to the lack of suitable in vitro systems, these assays are carried out in experimental animals. This practice increases cost and development time but also creates significant ethical issues. We recently developed a 3D culture system that allows us to expand human tissue stem cells fro",{"id":211,"funder":7,"programme":8,"title":212,"piName":10,"institution":213,"country":74,"year":13,"amount":21,"abstract":214},"cordis-european-research-council-award-737609","Neuromicronica: Modular behavioural neuroscience","SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE","Neurological disorders, particularly dementia, constitute arguably the greatest socioeconomic challenge to the aging European continent. There is growing realization that rodents can serve as models not just for basic neurobiological processes (e.g. synaptic transmission) but also for remarkably complex, primate-like and even human-like cognitive operations such as perception, memory, economics, social interaction, and decision making. Better rodent models for cognition are necessary to test the",{"id":216,"funder":7,"programme":8,"title":217,"piName":10,"institution":218,"country":52,"year":13,"amount":219,"abstract":220},"cordis-european-research-council-award-768258","A compact radioisotope dating device for rapid sample analysis","THE UNIVERSITY OF MANCHESTER","€149,924","The FNPMLS project (ERC n.648381) has successfully demonstrated that resonance ionization spectroscopy can be performed efficiently and with high resolution on an accelerated beam (CRIS). This novel and versatile methodology has been used to measure exotic nuclei down to rates of less than 20 atoms\u002Fsecond. In order to achieve these results the CRIS method has had to efficiently remove interference isotopes that would otherwise saturate the detectors. The key advantages of the method are its high",{"id":222,"funder":7,"programme":8,"title":223,"piName":10,"institution":224,"country":74,"year":13,"amount":225,"abstract":226},"cordis-european-research-council-award-754802","A novel instrument to identify chiral molecules for pharmaceutics and bio-chemistry.","POLITECNICO DI MILANO","€149,375","This proposal aims at bringing to the market a revolutionary device to uniquely identify the chirality of molecules. An object is chiral if it differs from its mirror image, like our left and right hands. Chirality plays an extremely important role in two main fields: (1) Many drugs are chiral and selecting one of the two forms often enables the pharma industry to extend patent franchise, thus increasing profitability, and to improve the quality, safety and efficacy of the drug. (2) Researchers ",{"id":228,"funder":7,"programme":8,"title":229,"piName":10,"institution":230,"country":52,"year":13,"amount":231,"abstract":232},"cordis-european-research-council-award-767372","A neural network builder with remotely controlled parallel computing","UNIVERSITY COLLEGE LONDON","€148,550","Neural network simulations have been a driving force behind our advances in the artificial intelligence filed, but also a key tool in our understanding of the human brain. However, exploring such networks usually engages substantial computational resources requiring specific programing skills and dedicated facilities. In our main project NETSIGNAL, we have developed computational environment ARACHNE aiming to facilitate high-end neural network exploration among scientific and industrial users. A",{"id":234,"funder":7,"programme":8,"title":235,"piName":10,"institution":236,"country":20,"year":13,"amount":21,"abstract":237},"cordis-european-research-council-award-754735","Automated tools for atomic resolution mapping of electrostatic fields in the electron microscope","UNIVERSIDAD COMPLUTENSE DE MADRID","The overarching goal of this proposal is to produce a software tool that will allow inexpensive atomic resolution mapping of electrostatic potentials and fields within materials in the electron microscope. Such mapping capabilities could revolutionize our understanding of future materials for devices based on exploiting functionalities such as ferroelectric polarization. During the last decade, the scientific community has addressed this pressing need by developing microscopy techniques sensitiv",{"id":239,"funder":7,"programme":8,"title":240,"piName":10,"institution":241,"country":242,"year":13,"amount":21,"abstract":243},"cordis-european-research-council-award-727761","Local molecular profiling of tumor tissue sections: towards personalized immunotherapy","IBM RESEARCH GMBH","CH","Cancer heterogeneity has reinforced the need for personalized treatment modalities. Pre-therapeutic diagnostic testing of heterogeneous tumors helps avoid inefficacious treatments, optimizes targeted therapy, and improves quality of life. Within targeted therapy, immunotherapy has led to significant improvements in treatment outcomes and is swiftly being integrated in diagnostic workflows.  In this context, routine diagnostic tests currently do not exist, and treatments are further challenged by",{"id":245,"funder":7,"programme":8,"title":246,"piName":10,"institution":247,"country":31,"year":13,"amount":248,"abstract":249},"cordis-european-research-council-award-780453","Redefining Virtual Reality Therapy for Anxiety Disorders","DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV","€148,403","Social anxiety disorder (SAD) – the most common type of anxiety disorders – has severe emotional, financial and social consequences for patients, their families and their social network. Affecting about 7% of Europeans at some point in their life, SAD produces substantial societal cost due to long lasting treatments and extensive periods of reduced working capacity. To address this important problem, the project will establish an innovative system for treating SAD by exploiting the proven therap",{"id":251,"funder":7,"programme":8,"title":252,"piName":10,"institution":253,"country":31,"year":13,"amount":254,"abstract":255},"cordis-european-research-council-award-754453","Advanced platform for profiling of therapeutic targets and functional analysis of circulating tumour cells in cancer patients","UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF","€149,825","As an alternative to invasive needle biopsies, the analysis of CTCs released by metastatic lesions into the blood has been recently introduced by the PI as “liquid biopsy”.  The molecular analysis of CTCs before and during treatment could supply a real-time status of the landscape of metastatic tumor cell clones in an individual cancer patient. CTCs might reveal representative information on metastatic cells located at different sites because the blood represents a pool of tumor cells potentiall",{"id":257,"funder":7,"programme":8,"title":258,"piName":10,"institution":259,"country":172,"year":13,"amount":21,"abstract":260},"cordis-european-research-council-award-779971","SFICAM: Ultrafast Fiber-Based Single-Photon Camera for Advanced Microscopy","WEIZMANN INSTITUTE OF SCIENCE","Light microscopy is critical to many fields, from biology and medicine to technology development and industry. One important breakthrough that enabled the development of super-resolution microscopy was the development of enhanced cameras capable of recording low light-level images with single-photon sensitivity. However such gain in spatial resolution is compromised by low temporal resolution, since these cameras work at video rate or somewhat faster, while many applications require to character",{"id":262,"funder":7,"programme":8,"title":263,"piName":10,"institution":264,"country":265,"year":13,"amount":21,"abstract":266},"cordis-european-research-council-award-780170","TeraHertz quasiOptical Receiver","CHALMERS TEKNISKA HOGSKOLA AB","SE","Remote sensing and monitoring in various environments solves many scientific and societal problems. Examples are: industrial air pollution control, global atmosphere surveillance, our planet system and the universe exploration, process controls in industry, and material research in laboratories. Molecular absorption\u002Femission feature, combined with a high penetration depth of THz waves through dust, short wavelength allowing for high pointing directivity, all these factors determine the uniquenes",{"id":268,"funder":7,"programme":8,"title":269,"piName":10,"institution":183,"country":52,"year":13,"amount":270,"abstract":271},"cordis-european-research-council-award-768728","Rapid production of HUMAN MAST CELLS","€148,914","Mast cells are involved in the allergic response, anaphylaxsis, wound healing and angiogenesis. When activated via IgE, damage\u002Fpathogen-induced molecules or complement components, the granules of mast cells release proteases. Dysregulation of mast cells is implicated in allergies of the skin and airways, autism, chronic fatigue syndrome, pain, mastocytoma and intestinal dysmotility. Strategies to limit the damaging effects of mast calls are needed. However, the development of novel treatments is",{"id":273,"funder":7,"programme":8,"title":274,"piName":10,"institution":275,"country":172,"year":13,"amount":21,"abstract":276},"cordis-european-research-council-award-755301","Hierarchical Inorganic Nanomaterials as Next Generation Catalysts and Filters","BEN-GURION UNIVERSITY OF THE NEGEV","In the coming few decades, two major global grand challenges will continue to attract the attention of scientists and engineers in academia and industry: achieving clean water and clean energy. This PoC establishes the development of two prototypes, water oxidation catalyst and water purification filter, by creating inexpensive, abundant and versatile hierarchical structures of inorganic nanomaterials (HSINs). The formation of HSINs has been one of the major obstacles toward achieving a technolo",{"id":278,"funder":7,"programme":8,"title":279,"piName":10,"institution":280,"country":242,"year":13,"amount":21,"abstract":281},"cordis-european-research-council-award-737548","A platform for augmented video content","UNIVERSITA DELLA SVIZZERA ITALIANA","Video content uploaded on social video sharing systems such as YouTube, Vimeo, or Dailymotion has experienced an exponential growth in the past years, making them the favorite medium for advertisement. The ease of sharing and accessing video content has also provoked significant efforts on the side of content creators and owners aimed at protecting their video assets from illegal reproduction and distribution, including the distribution through different channels, the use of digital right manage",{"id":283,"funder":7,"programme":8,"title":284,"piName":10,"institution":285,"country":31,"year":13,"amount":21,"abstract":286},"cordis-european-research-council-award-737566","Mining Sandboxes for Automatic App Protection","UNIVERSITAT DES SAARLANDES","Today’s industry is more vulnerable to cyberattacks than ever. The biggest threat comes from advancedpersistent threats that targets the sensitive data of a specific company. Such a threat may come along asan innocuous app that starts its malicious behavior only when the mobile logs into the corporate network.At the same time, such threats can be made undetectable through testing or code analysis.The ERC SPECMATE project has developed a technology named BOXMATE that protects against unexpectedch",{"id":288,"funder":7,"programme":8,"title":289,"piName":10,"institution":290,"country":31,"year":13,"amount":21,"abstract":291},"cordis-european-research-council-award-768740","Microchannels for controlling cellular mechanotransduction","CHRISTIAN-ALBRECHTS-UNIVERSITAET  ZU KIEL","Cells respond to external mechanical stimuli through an activation of a cellular mechanism called mechanotransduction. The cellular responses in this mechanism are expressed by a modification in cellular proliferation, migration and differentiation, as well as in a strengthening of their adhesion. Likewise, diseases such as cancer and cardiac dysfunctions are also related to cellular mechanotransduction. Here we propose to take a novel 3D material porous material towards commercial applications.",{"id":293,"funder":7,"programme":8,"title":294,"piName":10,"institution":295,"country":20,"year":13,"amount":225,"abstract":296},"cordis-european-research-council-award-768626","High Performance Genomics for Software Defined Infrastructures","BARCELONA SUPERCOMPUTING CENTER CENTRO NACIONAL DE SUPERCOMPUTACION","The Hi-OMICS PoC aims to pave the road to commercialisation of the Hi-OMICS Controller, a Software Defined Infrastructure Controller (SDI) specifically designed to efficiently manage Computational Genomics workloads running on upcoming SDI platforms. The necessary activities  to achieve this status are structured in two blocks: 1) Market analysis, Commercialisation Plan and the definition and implementation of a IPR protection  plan for the Hi-OMICS Controller; and 2)  Software development effor",{"id":298,"funder":7,"programme":8,"title":299,"piName":10,"institution":300,"country":31,"year":13,"amount":301,"abstract":302},"cordis-european-research-council-award-755161","PReparing Introduction to MArket of SKOTI (PRIMASKOTI) - a breakthrough solution for real-time studies of cytoskeletal motors at single-molecule resolution","EBERHARD KARLS UNIVERSITAET TUEBINGEN","€149,238","The PRIMASKOTI project will prepare the commercialization of SKOTI—the Swiss Knife for Optical Tweezers and Imaging. The scientific instrument SKOTI is designed to measure interactions between single biomolecules with a focus on cytoskeletal molecular machines. SKOTI combines several state-of-the-art microscopy techniques with contact-less mechanical manipulation, so-called optical tweezers. Because of its ultra high stability, SKOTI has its particular strengths in experiments requiring a solid ",{"id":304,"funder":7,"programme":8,"title":305,"piName":10,"institution":206,"country":207,"year":13,"amount":21,"abstract":306},"cordis-european-research-council-award-737634","Integrated Network of Sleep-Optimizing Modules for Norm-Informed Adaptive Behavioural, Environmental And Therapeutic Internet Training","Major depression is among the most prevalent and burdening health hazards. Our best chance to combat the pending global pandemic is to provide preventive interventions to identified people at risk. The strongest modifiable risk factor is insomnia. Insomnia can be ameliorated by its recommended treatment, cognitive behavioural therapy (CBT), which indeed improves depression outcomes. Current health infrastructures however cannot supply CBT for the ±10% of the population suffering from insomnia. I",{"id":308,"funder":7,"programme":8,"title":309,"piName":10,"institution":310,"country":31,"year":13,"amount":311,"abstract":312},"cordis-european-research-council-award-768524","A new tool in drug development: mapping of compound-protein interaction using forward genetics","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€149,563","Development of new medicines such as chemotherapeutic drugs requires a detailed understanding of their biological mechanism of action. What are the desired and undesired interactions with biological molecules? It is our goal to found a start-up company that will provide a solution to this challenge. Using novel and ground-breaking approaches we can identify target structures and interaction partners of small bioactive molecules at an unmatched and unprecedented resolution. ERC PoC funding will b",{"id":314,"funder":7,"programme":8,"title":315,"piName":10,"institution":316,"country":317,"year":13,"amount":21,"abstract":318},"cordis-european-research-council-award-766656","Bottom-up Energy Efficient Emulsification and Structured Materials","SOFIA UNIVERSITY ST KLIMENT OHRIDSKI","BG","Bottom-up Energy-Efficient Emulsification and Structured Materials FabricationBuilding on the novel platform technology we have recently pioneered for the bottom-up bulk generation of shapes, as well as for self-emulsification from liquid droplets, we are developing pre-commercialization activities. The existing method creates, without the use of lithography, applied fields, or other expensive techniques, micro- and nanoparticles of regular geometric shapes, including fibers. By cycling temperat",{"id":320,"funder":7,"programme":8,"title":321,"piName":10,"institution":322,"country":52,"year":13,"amount":323,"abstract":324},"cordis-european-research-council-award-755191","Biomimetic mineralization for enamel regeneration","QUEEN MARY UNIVERSITY OF LONDON","€149,728","Dental enamel has a unique chemical composition and a remarkable well-defined hierarchical structure, which together are responsible for its outstanding properties and critical functionality. Once lost, this tissue cannot be regenerated and is directly involved in a variety of dental problems that affect a large percentage of the world population. This ERC PoC project (ENAMULATE) aims to develop the world’s first human dental enamel regeneration material capable of recreating natural enamel in s",{"id":326,"funder":7,"programme":8,"title":327,"piName":10,"institution":328,"country":329,"year":13,"amount":21,"abstract":330},"cordis-european-research-council-award-755154","Augmented Reality Wearable Platform and Screen: Proof of Concept and Commercialization","KOC UNIVERSITY","TR","Wear3D display technology project is an ERC-Advanced project and offers novel optical solutions for wearable (or head-mounted) displays to achieve very wide field-of-view and natural-looking 3D. The Wear3D technology has a lot of potential as the global consumer market for AR and VR are expected to reach more than US$30 billion and US$120 billion by 2022, respectively. Hardware devices will be more than 30% of the total market.Within the ERC-AdG, our team developed a novel head-worn system named",{"id":332,"funder":7,"programme":8,"title":333,"piName":10,"institution":334,"country":52,"year":13,"amount":335,"abstract":336},"cordis-european-research-council-award-754695","Adapter for a commercial grade camera or a smart phone to perform  depth resolved imaging","UNIVERSITY OF KENT","€149,300","The proposal refers to a patented adapter that can transform a commercial grade digital camera or the camera in a smart phone into a depth resolved imaging instrument. Several adapters will be assembled, making use of optical coherence tomography (OCT) technology protected by some other of PI’s patents. The activity takes advantage of recent progress in commercial grade cameras in terms of their modes of operation as well as in terms of parameters of their devices, such as sensitivity and speed ",{"id":338,"funder":7,"programme":8,"title":339,"piName":10,"institution":340,"country":207,"year":13,"amount":21,"abstract":341},"cordis-european-research-council-award-693623","Development of an Anger Regulation Tool for Hand-Held Devices","STICHTING VU","Our research team at the Amsterdam Emotion regulation Lab (emotionregulationlab.com) has recently established that avoidance movements can lower anger and aggression among individuals with chronic anger management problems. Building on and extending these findings, we propose to develop, test, and market an interactive application that runs on mobile devices such as smart phones and tablets. This Anger Reduction Tool (ART) will consist of a ‘serious game’ that trains people to make avoidance mov",{"id":343,"funder":7,"programme":8,"title":344,"piName":10,"institution":345,"country":207,"year":13,"amount":346,"abstract":347},"cordis-european-research-council-award-737619","ErasmusBlink: A low cost and easy to use measurement system for medical research with diagnostic potential","ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM","€149,938","Neuroscientists and clinicians use a wide range of behavioral tests to investigate the physiological mechanisms of learning and memory formation. One of the most objective and reliable tests is eyeblink conditioning, as it is extremely simple, it can be done in both humans and animals, it measures many aspects of how we learn in our daily life, and it can detect memory deficits in many neurological and psychiatric diseases. However, so far there are no low-cost reliable eyeblink conditioning set",{"id":349,"funder":7,"programme":8,"title":350,"piName":10,"institution":259,"country":172,"year":13,"amount":21,"abstract":351},"cordis-european-research-council-award-727218","Elimination of Senescent Cells Approach for treatment of COPD","Chronic Obstructive Pulmonary Disease (COPD) is estimated to affect up to 600 million people worldwide and by 2020 it will become the third most frequent cause of death. In Europe alone, COPD affects up to 10% of people (i.e. more people than breast cancer and diabetes) and it takes the life of around 300,000 Europeans each year. Current therapies are associated with a variety of side effects some of which can be acute and even life threatening. Moreover, none of the existing medications for COP",{"id":353,"funder":7,"programme":8,"title":354,"piName":10,"institution":345,"country":207,"year":13,"amount":21,"abstract":355},"cordis-european-research-council-award-767854","Triple negative breast cancer control through synergistic inhibition of EGFR and CDK9 signaling","Triple negative breast cancer (TNBC) is an aggressive disease, accounting for 15-20% of breast cancer cases, but disproportionally causing breast cancer-related death. TNBC does not express the targetable receptors ER, PR, and HER2 that are known to drive other forms of breast cancer. Mainstay practice for TNBC in the clinic is to treat with non-targeted cytotoxic chemotherapies. Long-term outcomes are however still poor, most likely owing to intrinsic drug resistance. Clinical trials have attem",{"id":357,"funder":7,"programme":8,"title":358,"piName":10,"institution":359,"country":12,"year":13,"amount":21,"abstract":360},"cordis-european-research-council-award-727427","'Total E-field Reconstruction using a MIchelson TEmporal Scan' for spatio-temporal metrology of ultrashort laser beams","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","The technology of femtosecond lasers now makes it possible to reach enormous light intensities with only moderate amounts of energy. These so-called Ultra-High Intensity (UHI) lasers have led to the development of a very active research field, which studies the interaction of light with matter at these extreme intensities. This field is largely motivated by the prospects of generating compact sources of high-energy particles and short-wavelength light, which are being foreseen for applications i",{"id":362,"funder":7,"programme":8,"title":363,"piName":10,"institution":364,"country":160,"year":13,"amount":365,"abstract":366},"cordis-european-research-council-award-727578","Plants as sensors for standardization and calibration of controlled environment chambers","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","€148,619","Research in plant biology & crop breeding conducted in controlled environment chambers (CECs) require that observed differences in measured plant traits between or within CECs are attributable to the imposed experimental treatment or breeding protocol rather than to heterogeneity and\u002For poor accuracy in the monitoring of different chamber environmental conditions. To date, no commercial product has been developed which tests standardization of environmental conditions within and between CECs of ",{"id":368,"funder":7,"programme":8,"title":369,"piName":10,"institution":11,"country":12,"year":13,"amount":21,"abstract":370},"cordis-european-research-council-award-754761","Innovative fungal strains for producing blue cheeses","The ERC project GenomeFun has revealed a substantial genetic and phenotypic variability within Penicillium roqueforti, which is the fungus used for the maturation of blue cheeses. The ERC project GenomeFun has also shown the existence of different genetic clusters harboring specific traits and has allowed the development of a protocol for inducing in the laboratory the natural process of sexual reproduction in this fungus. The present PoC BLUE project aims at proving the possibility to obtain an",{"id":372,"funder":7,"programme":8,"title":373,"piName":10,"institution":11,"country":12,"year":13,"amount":21,"abstract":374},"cordis-european-research-council-award-767579","Ultrasensitive Cartography of vectorial Force Fields at the nanoscale","This project aims at developing and disseminating a new class of ultrasensitive and vectorial force field sensors to build thenext generation of scanning probes with improved sensitivity and vectorial readout capacity. The vibrations of a singlyclamped silicon carbide nanowire (NW) are readout by optical techniques. Its vibrating extremity oscillates in bothtransverse directions with quasi-degenerated frequencies due to its quasi-cylindrical geometry. When approaching the NWabove a sample surfac",{"id":376,"funder":7,"programme":8,"title":377,"piName":10,"institution":11,"country":12,"year":13,"amount":21,"abstract":378},"cordis-european-research-council-award-768790","Multiple cellular screens using microfluidic droplets","Although some biotechnologies have made huge strides e.g. in automation, data generation, or biochemical methods, cellhandling still uses antiquated methods that limit the scale at which assays can be performed. Our ERC-funded microfluidicswork has lead to cutting-edge microdroplet manipulation tools for cell handling: While working with 3D cell cultures, wehave recently shown that we can obtain great increases in both throughput and detail, while reducing the sample use andthe machine footprint",{"id":380,"funder":7,"programme":8,"title":381,"piName":10,"institution":11,"country":12,"year":13,"amount":382,"abstract":383},"cordis-european-research-council-award-755456","Electrochemical Testing Platform for Advanced Energy Materials","€148,375","Throughout history, the Li-ion battery technology has relied on cationic redox reactions as the sole source of energy storage capacity. This is no longer true since 2013, where our group had demonstrated that Li-driven reversible formation of (O2)n peroxo-groups in new layered oxides led to extraordinary increases in energy storage capacity. To fully exploit this discovery we were granted in 2015 an advanced ERC grant entitled Anionic redox processes: A transformational approach for advanced ene",{"id":385,"funder":7,"programme":8,"title":386,"piName":10,"institution":387,"country":52,"year":13,"amount":388,"abstract":389},"cordis-european-research-council-award-767112","Few-Cycle Electric Field Waveforms for Advanced Science and Technology","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€137,155","The aim is the development of a user friendly high power few cycle, phase stable, light source in the 1500-2000 nm wavelength range. This builds on technical feasibility demonstrated during the ASTEX Advanced Grant. To fully exploit the potential of this light source it is necessary now to optimize the following characteristics: peak power, the ultimate pulse duration, stability and convenience of use. We hope to do this by building on the work carried out in the ASTEX project, that demonstrated",{"id":391,"funder":7,"programme":8,"title":392,"piName":10,"institution":387,"country":52,"year":13,"amount":21,"abstract":393},"cordis-european-research-council-award-737570","From Neurons to Robots: Non-Invasive, General-Purpose Interfacing With Human Spinal Motor Neurons","INTERSPINE (“From Neurons to Robots: Non-Invasive, General-Purpose Interfacing With Human Spinal Motor Neurons”) aims at exploiting the methodologies developed during the ERC Advanced grant DEMOVE (“Decoding the Neural Code of Human Movements for a New Generation of Man-machine Interfaces”). During DEMOVE, novel bioelectrodes and computational methods have been developed to enrich our fundamental understanding of the mechanisms underlying the generation of human movements, from the cellular leve",{"id":395,"funder":7,"programme":8,"title":396,"piName":10,"institution":397,"country":20,"year":13,"amount":21,"abstract":398},"cordis-european-research-council-award-754627","A metabolism-based prognostic biomarker for prostate cancer","ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS","Prostate cancer (PC) is the most prevalent tumour type among men. The fraction of patients that exhibit disease recurrence can reach 15% and they face an uncertain future, since this type of tumour is prone to resist to subsequent therapeutic strategies. Current guidelines for treatment of PC include prostatectomy or radiotherapy as first line therapy for localized disease, and chemical castration followed by chemotherapy for recurrent PC. The lack of capacity to identify therapy responders vs. ",{"id":400,"funder":7,"programme":8,"title":401,"piName":10,"institution":402,"country":207,"year":13,"amount":21,"abstract":403},"cordis-european-research-council-award-755402","Synthetic DCs for a T cEll ProdUction Platform","STICHTING RADBOUD UNIVERSITEIT","Cancer immunotherapy and adoptive transfer of genetically manipulated T cells in particular has shown promising results for the treatment of cancer. Central in cancer immunotherapy is the activation of tumour-specific T cells. However, the wide-spread clinical use of T cell therapies remains limited due to costly, time-consuming and labour-intensive processes associated with the ex vivo activation and expansion of tumour-specific T cells. Artificial antigen presenting cells (aAPCs) have been dev",{"id":405,"funder":7,"programme":8,"title":406,"piName":10,"institution":407,"country":242,"year":13,"amount":21,"abstract":408},"cordis-european-research-council-award-768415","Neuroprotective human antibodies to the flexible tail of the prion protein","UNIVERSITAT ZURICH","The misfolding of the cellular prion protein (PrPC) causes infectious neurodegenerative conditions called prion diseases. In the framework of the ERC-funded study “The Prion Protein in Health and Disease” the team of Adriano Aguzzi has discovered that antibodies against the flexible tail (FT) of PrPC are neuroprotective against prion pathologies. Here we propose to clone and express such antibodies from humans and to develop them as antiprion therapeutics. The principal investigator has founded ",{"id":410,"funder":7,"programme":8,"title":411,"piName":10,"institution":412,"country":20,"year":13,"amount":413,"abstract":414},"cordis-european-research-council-award-727484","A new technology of microthermal sensing for application in microcalorimetry","UNIVERSIDAD DE SANTIAGO DE COMPOSTELA","€149,250","ANTS aims to prove the viability of a novel thermal microsensor, with highly improved thermal, temporal and spatial resolution, to be the basis of a breakthrough micro\u002Fnano-calorimeter. The resulting device shall quantify binding rates and enthalpy\u002Fentropy changes in interactions of biological interest in a much more accurate and straightforward manner than available techniques. Consequently, ANTS-microcalorimeter will facilitate enormously drug discovery and development of biomedical products a",{"id":416,"funder":7,"programme":8,"title":417,"piName":10,"institution":418,"country":52,"year":13,"amount":419,"abstract":420},"cordis-european-research-council-award-754682","Electrocatalytic Nanoreactors for Absorption, Detection and Decontamination of Hazardous Compounds","THE UNIVERSITY OF NOTTINGHAM","€149,912","Chemical warfare agents (CWA) are one of the most odious weapons of mass destruction, designed to incapacitate humans by causing blistering, choking, internal bleeding and vomiting on a grand scale. CWA are inexpensive and relatively easy to synthesise making them accessible to terrorist groups, providing a means for the administration of large scale damage with only small quantities of materials. Current state-of-the-art methods to detect or decontaminate CWA lack efficiency and flexibility and",{"id":422,"funder":7,"programme":8,"title":423,"piName":10,"institution":424,"country":74,"year":13,"amount":21,"abstract":425},"cordis-european-research-council-award-755075","Developing a cure for retinitis pigmentosa due to Usher syndrome","FONDAZIONE TELETHON ETS","The GeneVision proof-of-concept project spins from a major discovery made by the principle investigator (PI) within the RetGeneTx ERC project demonstrating that dual AAV vectors expand AAV DNA transfer capacity in the retina thus allowing delivery of genes whose size cannot be packaged in single AAVs. Thus, dual AAV vectors allow gene therapy of those inherited blinding conditions, like Usher syndrome type Ib (USHIB), Stargardt disease or other forms of retinitis pigmentosa, due to mutations in ",{"id":427,"funder":7,"programme":8,"title":428,"piName":10,"institution":171,"country":172,"year":13,"amount":21,"abstract":429},"cordis-european-research-council-award-754696","User behavior Simulation in built Environments","The impact of a building design or renovation on the behavior of its intended occupants can be assessed only after the building has been built and occupied (or the renovation has been completed). This is a risky proposition, because design mistakes can cause severe consequences in terms of under-performing buildings, reduced productivity, absenteeism, and general user dissatisfaction. During our ERC-funded project, titled NextGenBim, we were able to develop and demonstrate a method to computatio",{"id":431,"funder":7,"programme":8,"title":432,"piName":10,"institution":359,"country":12,"year":13,"amount":21,"abstract":433},"cordis-european-research-council-award-768722","All Aqueous, continuous, Solid-Liquid SYNergisticEXTRACTion of rare earth elements","It is a matter of strategic independence for Europe to urgently find processes taking into account environmental and economic issues, when mining and recycling rare earth elements (REE). As of 2015, only 1% of used REE were recycled in the EU and 80% of the mining operations were performed in China, hence representing a major Sword of Damoclès for the rest of the world’s economy. With SYNEXTRACT, we propose to leverage on discoveries made (and patented) within ERC-Adv REE-CYCLE, related to new e",{"id":435,"funder":7,"programme":8,"title":436,"piName":10,"institution":230,"country":52,"year":13,"amount":437,"abstract":438},"cordis-european-research-council-award-754704","Antibiotic intracellular delivery via virus-like carriers","€149,062","Taking inspiration from natural carriers, such as viruses, a new technology has been developed inour laboratories part of an ongoing ERC starting grant project, Molecular Engineering of Virus-likeCarriers (MEViC). We created synthetic viruses using polymers and thus safer materials. They areable of delivering high payload of specific drugs into cells with no detrimental effect. While testing foranticancer therapies, we identified a synthetic virus capable of targeting almost exclusivelymacrophag",{"id":440,"funder":7,"programme":8,"title":441,"piName":10,"institution":442,"country":31,"year":13,"amount":21,"abstract":443},"cordis-european-research-council-award-780964","OncoSeq: an innovative single-cell system for immunomonitoring","PARMENIDES STIFTUNG","Host immunity plays a central and complex role in tumour progression, and the quality and quantity of immune infiltrate at the tumour site is used as a prognostic marker of cancer progression. Therefore, detailed single-cell analysis of tumor infiltrating immune cells, and ultimately liquid biopsy of circulating immune cells, is of vital importance for the development of new and improved immunotherapy strategies, and for diagnosis, prognosis, patient stratification and follow-up.We propose in On",{"id":445,"funder":7,"programme":8,"title":446,"piName":10,"institution":447,"country":20,"year":13,"amount":448,"abstract":449},"cordis-european-research-council-award-713742","Computer-Aided Fashion with Yarn-Level Fabric Models","UNIVERSIDAD REY JUAN CARLOS","€149,545","The Animetrics ERC Starting Grant has led to the invention of the first computer models capable of simulating in an accurate, efficient and robust manner the behavior of full textiles using a yarn-level representation. The proposed models handle frictional yarn interactions at the small scale, yet they naturally produce the rich large-scale nonlinearity of textiles. In contrast, models used in the fashion, engineering, or VFX industries nowadays, describe textiles as a continuum, and do not reac",{"id":451,"funder":7,"programme":8,"title":452,"piName":10,"institution":259,"country":172,"year":13,"amount":21,"abstract":453},"cordis-european-research-council-award-737419","Growth detection and quantification (GDQ)","The growth rate of both bacterial and human cells has a central role in the clinical management of infectious diseases and malignancies. Virulent and aggressive bacterial strains have higher growth rates, which will decrease in response to successful treatment. Proliferation rates are also instrumental in the diagnosis, prognosis, and treatment of various cancer types, as the proliferation rate of human cells is one of the hallmarks of malignancy, evident by the widespread use of various prolife",{"id":455,"funder":7,"programme":8,"title":456,"piName":10,"institution":457,"country":207,"year":13,"amount":21,"abstract":458},"cordis-european-research-council-award-780765","Piloting cascaded continuous flow synthesis for the pharmaceutical industry","TECHNISCHE UNIVERSITEIT EINDHOVEN","PICASCO aims to deliver the commercial proof of concept of a novel endto-end flow manufacturing and a novel corresponding compact flow miniplant. This is performed through the first continuous 4-step solvent-freeflow manufacturing of a pharmaceutically relevant API compound at anindustrial scale. Currently applied batch manufacturing techniques leavemuch room for improved quality, efficiency, cost-effectiveness andenvironmental friendliness. Flow multi-step manufacturing can address allthese iss",{"id":460,"funder":7,"programme":8,"title":461,"piName":10,"institution":259,"country":172,"year":13,"amount":21,"abstract":462},"cordis-european-research-council-award-767058","Fighting Anxiety with Importin-based Therapeutics","Anxiety and stress-related conditions represent a significant health burden in modern society. Anxiety disorders are currently treated with a variety of agents targeting synaptic mechanisms. These agents either directly affect neurotransmitter receptor systems or modulate neurotransmitter levels or availability, but their long-term use is limited by problematic side effects and suboptimal efficacy. The development of new anxiolytic drugs has been fraught with difficulty, hence there is a need fo",{"id":464,"funder":7,"programme":8,"title":465,"piName":10,"institution":466,"country":265,"year":13,"amount":10,"abstract":467},"cordis-european-research-council-award-727646","Soccermatics: data for football fans and clubs","UPPSALA UNIVERSITET","Data plays an increasingly important role in sport, from monitoring of fitness of athletes to success statistics in baseball. In football (soccer) the team performance is more important than the performance of any one individual. While every team has its star players, it is the ability of the team to function as a unit that is the key to its success. For the data analyst, this presents a challenge: how to measure, understand and improve team performance. My research during an ERC funded action (",{"id":469,"funder":7,"programme":8,"title":470,"piName":10,"institution":418,"country":52,"year":13,"amount":471,"abstract":472},"cordis-european-research-council-award-754745","ImmortaSTEM: Transient Immortalisation for Patient Stem Cell Expansion and Therapeutic Application","€149,932","Under an ERC Advanced Grant, and subsequent PoC grant, Professor Shakesheff's team have invented a new intracellular delivery system that overcomes a problem in drug delivery in stem cell culture as well as regenerative medicine and other therapeutic approaches. The system, called GAG-binding enhanced transduction (GET), enables intracellular delivery of proteins, nucleic acids and particles into cells that resist other non-viral strategies. The work under ERC Advanced Grant and PoC funding has ",{"id":474,"funder":7,"programme":8,"title":475,"piName":10,"institution":476,"country":74,"year":13,"amount":477,"abstract":478},"cordis-european-research-council-award-737561","The role of non coding RNA in organismal ageing","IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS","€149,950","The DNA damage response (DDR) is a set of cellular events that follow the generation of a DNA damage. We have previously discovered a novel class of small non-coding RNAs, named DNA damage RNAs (DDRNAs), which are necessary for the full DDR activation upon a DNA double-strand break generation. Our preliminary data show that also at damaged\u002Fdysfunctional telomeres telomeric transcrips are produced. By using antisense oligonucleotides (ASOs) targeting them, we aim at modulating DDR in cultured cel",{"id":480,"funder":7,"programme":8,"title":481,"piName":10,"institution":259,"country":172,"year":13,"amount":21,"abstract":482},"cordis-european-research-council-award-737473","NovEl Strategies for treatIng tendon-to-bone injurieS - kiNESIS","Body movement requires efficient transfer of force from contracting muscles to bone. Damage to the tendinous insertions is the 8th leading cause of disease burden and is the largest single cause of work loss in Europe. Historically, approaches for improving healing in these attachment units have focused on modifying repair techniques and rehabilitation protocols. These methods are proven to be very ineffective, since failure rates of as high as 94% are often reported. We have discovered that two",{"id":484,"funder":7,"programme":8,"title":485,"piName":10,"institution":486,"country":31,"year":13,"amount":487,"abstract":488},"cordis-european-research-council-award-768210","EVOLchip - predicting antibiotic resistance for sustainable antibiotic stewardship","FREIE UNIVERSITAET BERLIN","€148,500","Antibiotic resistance is rife (fig. 1), yet notoriously difficult to predict. Here I propose to assess the applied potential of an easy to use device, ‘EVOLchip’  that allows to test antibiotic treatment schemes within a few weeks for their risk of inducing antimicrobial resistance.  If successful, this would allow to use current antibiotics much longer and to reuse old antibiotics in combination. Such tests can be conducted at hospital level by any trained medical microbiologist and hence be im",{"id":490,"funder":7,"programme":8,"title":491,"piName":10,"institution":492,"country":172,"year":13,"amount":21,"abstract":493},"cordis-european-research-council-award-767931","Assay for cancer diagnostics by quantification of 5hmC","TEL AVIV UNIVERSITY","Assay for cancer diagnostics by quantification of 5hmC5-hydroxymethylcytosine (5hmC) is a modified form of the DNA base cytosine and is an important epigenetic marker linked to regulation of gene expression in development and tumorigenesis. The loss of 5hmC is observed across a wide spectrum of malignant tumours. The goal of the proposed project is to utilize a novel chemo-enzymatic labelling scheme developed within the framework of my ERC project in order to develop a high-throughput assay capa",{"id":495,"funder":7,"programme":8,"title":496,"piName":10,"institution":497,"country":242,"year":13,"amount":21,"abstract":498},"cordis-european-research-council-award-768565","Precision mass spectrometry to leverage applications in life and environmental sciences","SPECTROSWISS SARL","The unbeatable performance leaders in molecular analysis of biological and environmental samples are the Fourier transform mass spectrometers (FTMS): Orbitrap FTMS and ion cyclotron resonance (FT-ICR MS). However, even FTMS approaches suffer from performance limitations when facing the molecular complexity of samples in modern applications. The primary reasons for these limitations are the space charge effects – strong Coulombic interactions of many ions oscillating in the trapping devices. Appl",{"id":500,"funder":7,"programme":8,"title":501,"piName":10,"institution":502,"country":52,"year":13,"amount":503,"abstract":504},"cordis-european-research-council-award-737557","Acoustics for Next Generation Sequencing","UNIVERSITY OF GLASGOW","€149,995","Since completion of the first human genome sequence, the demand for cheaper and faster sequencing methods has increased enormously. This need has driven the development of second-generation sequencing methods, or next-generation sequencing (also known as NGS or high throughput sequencing). The creation of these platforms has made sequencing accessible to more laboratories, rapidly increasing the volume of research, including clinical diagnostics and its use in directing treatment (precision medi",{"id":506,"funder":7,"programme":8,"title":507,"piName":10,"institution":508,"country":207,"year":13,"amount":21,"abstract":509},"cordis-european-research-council-award-737637","Explore the potentialities of living implants for medical devices","UNIVERSITEIT TWENTE","IMPLANTaLive coating technology provides an exciting business opportunity. IMPLANTaLive offers unique advantages of societal and economic importance such as public health and sick leave. Living, dynamic coatings for medical devices, ie. coatings with proper cell response upon implantation, are attractive for restoring body function. Conventional implant coatings are of inferior quality and therefore the majority, if not all, biocoatings fail in suitably interacting with host tissue. This poor pe",{"id":511,"funder":7,"programme":8,"title":512,"piName":10,"institution":402,"country":207,"year":13,"amount":21,"abstract":513},"cordis-european-research-council-award-737607","Commercialising a novel diagnostic panel for patient stratification in Age-related MACULAr Degeneration","In MACULA2 we aim to develop a genetic diagnostic test for complement activation that will allow proper stratification of patients with age-related macular degeneration (AMD). AMD is an inflammatory disease, the #1 cause of blindness in the world, with 196 million patients estimated for 2020. Such a test does not currently exist, strongly hampering drug development and patient treatment. Poor patient stratification contributes to high failure rates in trials for AMD. Local and systemic inflammat",{"id":515,"funder":7,"programme":8,"title":516,"piName":10,"institution":517,"country":31,"year":13,"amount":10,"abstract":518},"cordis-european-research-council-award-737616","Sodium-ion pouch cells with high energy and power density","TECHNISCHE UNIVERSITAET ILMENAU","The growing market appeal of rechargeable lithium ion batteries (LIBs) for electric vehicles and portable electronics as well as the high cost and scarcity of lithium are driving research towards developing alternatives to LIBs. Sodium ion batteries (SIBs) have attracted considerable scientific and industrial attention as a potential alternative to LIBs with great economic benefits, which mainly attributes to the low cost and natural abundance of sodium. Moreover, SIBs share many similar charact",{"id":520,"funder":7,"programme":8,"title":521,"piName":10,"institution":522,"country":242,"year":13,"amount":21,"abstract":523},"cordis-european-research-council-award-755383","Multi-well High-resolution Electrophysiology Platform","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","MwHresEP: Multi-well High-resolution Electrophysiology PlatformThe aim of this proof-of-concept project is to make initial steps in translating the high-density microelectrode array (HD-MEA) chip technology, which has been developed in the ERC project “NeuroCMOS” (AdG 267351, Subproject 1) into a commercial product. The project will be performed in collaboration with the spin-off company MaxWell Biosystems AG (http:\u002F\u002Fwww.mxwbio.com\u002F) that has been founded after the NeuroCMOS project end by colla",{"id":525,"funder":7,"programme":8,"title":526,"piName":10,"institution":527,"country":52,"year":13,"amount":503,"abstract":528},"cordis-european-research-council-award-737515","Transforming Gender Justice for Conflict-Related Sexual Violence:  The Gender Justice Prototype Framework for Analysis and Action","GOLDSMITHS' COLLEGE","How to provide justice for conflict-related sexual violence (CRSV) has now become a highly visible and challenging global problem with few solutions. The TRANSFORM project addresses this problem by creating a prototype Gender Justice Framework to guide analysis of, and responses to, conflict-related sexual violence. The ERC Gender of Justice Project (GoJ) provides a unique array of justice indicators and innovative methods that can deliver ground-breaking strategies to combat impunity for confli",{"id":530,"funder":7,"programme":8,"title":531,"piName":10,"institution":224,"country":74,"year":13,"amount":225,"abstract":532},"cordis-european-research-council-award-754916","Innovative Neutron source for non destructive TEsting and tReatments","The INTER project aims at the design and production of a proof of concept demonstrator component essential for the development of a novel, tunable and portable neutron source. Neutron beam-based analysis (neutron diffraction, neutron activation analysis, active interrogation) and imaging (radiography, tomography) methods are a powerful tool for non-destructive testing (NDT) of materials and find numerous important applications in industry, security, and material science and technology.Use of las",{"id":534,"funder":7,"programme":8,"title":535,"piName":10,"institution":407,"country":242,"year":13,"amount":21,"abstract":536},"cordis-european-research-council-award-727444","Towards clinical trials for a novel treatment for stroke","Stroke is the leading cause of adult disability and represents a major health problem in the EU and the Western world. Despite available acute care treatment and rehabilitation therapies, more than half of the patients remain disabled and there is a large unmet medical need accordingly. Regeneration of interrupted nerve fiber tracts and plastic “hardware” changes in the adult mammalian central nervous system are extremely restricted, a phenomenon which represents a key reason for the low degree ",{"id":538,"funder":7,"programme":8,"title":539,"piName":10,"institution":540,"country":12,"year":13,"amount":10,"abstract":541},"cordis-european-research-council-award-727682","CacheMire: Wireless Edge Caching Platform","CENTRALESUPELEC","Mobile data traffic sharply increases each year, due to the rich multi-media applications, video streaming, social networks, and billions of connected users and devices. This increasing mobile data traffic is expected to reach by 2018 roughly 60% of total network traffic. In this regard,  caching contents at the edge of the network, namely at the base station and user terminals, is a promising way of offloading the backhaul (especially crucial in dense network deployments) and decreasing the end",{"id":543,"funder":7,"programme":8,"title":544,"piName":10,"institution":545,"country":207,"year":13,"amount":21,"abstract":546},"cordis-european-research-council-award-768166","Hypoxic Tumour Models for Photoactivatable Ruthenium-based Chemotherapy","UNIVERSITEIT LEIDEN","In this Proof-of-Concept project I will show the commercial potential of ruthenium-based photoactivated chemotherapy (PACT) compounds developed in my ERC Starting Grant by demonstrating their efficacy on hypoxic cancer models. Photoactivated chemotherapy  is a new class of phototherapy to treat cancer. In principle, PACT looks similar to photodynamic therapy (PDT): light irradiation of the tumour in vivo leads to local activation of the anticancer prodrug, thereby limiting the toxicity of the tr",{"id":548,"funder":7,"programme":8,"title":549,"piName":10,"institution":550,"country":20,"year":13,"amount":21,"abstract":551},"cordis-european-research-council-award-755196","Platform for label-free quantitative detection of single proteins and extracellular vesicles","FUNDACIO INSTITUT DE CIENCIES FOTONIQUES","The main objective of the IBIS project is to develop an ultrasensitive, compact and low cost platform for the label-free quantitative detection of single proteins, and specifically the characterisation of nanometric extracellular vesicles. We will develop a prototype to transfer our novel detection scheme from the laboratory to the clinical environment and, based on user-feedback, develop a commercialization plan. In the fight against cancer and neurodegenerative diseases, exosomes are being per",{"id":553,"funder":7,"programme":8,"title":554,"piName":10,"institution":171,"country":172,"year":13,"amount":21,"abstract":555},"cordis-european-research-council-award-737467","The development of Personalised Host Response Diagnostic kit","Drug resistance is a major reason for failure in cancer chemotherapy and\u002For modern targeted drugs. While tumours usually initially respond to therapy, resistance occurs within several cycles of treatments, or later on when patients are off therapy. Until recently, acquired and intrinsic resistance mechanisms for therapy were thought to be solely tumour driven. They are usually measured after tumours relapse or after several lines of treatments.  However, in our ERC starting grant (HostResponse N",{"id":557,"funder":7,"programme":8,"title":558,"piName":10,"institution":559,"country":195,"year":13,"amount":21,"abstract":560},"cordis-european-research-council-award-754890","Nanocomposite Solutions","UNIVERSITAET FUER BODENKULTUR WIEN","Composite polymer materials are a rapidly growing market. These materials are also strongly driving device and product innovation by allowing creation of multifunctional, light-weight and moldable components for various products from airplanes to electronics and textiles. We have invented new methods for scalable production of inorganic nanomaterials that allow us to control their distribution and properties in polymer materials. In short, we can mask functional nano- or microparticles by a thin",{"id":562,"funder":7,"programme":8,"title":563,"piName":10,"institution":310,"country":31,"year":13,"amount":21,"abstract":564},"cordis-european-research-council-award-737530","Active Organ Phantoms for Medical Robotics","Robot-assisted and minimally invasive medical procedures are impacting medical care by increasing accuracy, reducing cost, and minimizing patient discomfort and recovery times after interventions. Developers of commercial robotic surgical systems and medical device manufacturers look for realistic phantoms that can be used in place of animal experiments or cadavers to test procedures and to train medical personnel. Existing phantoms are either made from hard materials, or they lack anatomical de",{"id":566,"funder":7,"programme":8,"title":567,"piName":10,"institution":568,"country":207,"year":13,"amount":21,"abstract":569},"cordis-european-research-council-award-737612","Circulating tumor cells for tailoring BMP targeted therapies","ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM","Gastro-intestinal (GI) cancers, including gastro-esophageal junctional (GEJC), gastric (GC), colorectal (CRC) and pancreatic cancer (PC) are devastating malignancies that annually affect over 2 million persons worldwide and lead to more than 600,000 deaths (Globocan 2012). Given the current trends, the incidence of GI cancer is expected to increase further. Conventional therapies include chemo- and radiation therapy combined with surgery. However, amongst cancer patients, GI cancer patients have",{"id":571,"funder":7,"programme":8,"title":572,"piName":10,"institution":573,"country":31,"year":13,"amount":574,"abstract":575},"cordis-european-research-council-award-737592","Viral Vaccine Vectors in Personalized Medicine","HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH","€149,858","Melanoma and lymphoma are tumors that strike millions of people worldwide and require aggressive and expensive therapies. Numerous therapies are already being used or in the pipeline, yet all of them focus on the rapid elimination of the active neoplastic process. They do not provide options for long-term surveillance and deterrence of minimal residual disease, that is, of cancer relapse arising from the few tumor cells that survive the aggressive bout of therapy. Therefore, even patients consid",{"id":577,"funder":7,"programme":8,"title":578,"piName":10,"institution":579,"country":178,"year":13,"amount":10,"abstract":580},"cordis-european-research-council-award-768815","Development of a policy to stop the suffering caused by Nodding Syndrome and Onchocerciasis associated epilepsy","UNIVERSITEIT ANTWERPEN","Nodding syndrome (NS) is a form of epilepsy, characterized by head-nodding, often associated with severe intellectual disability, psychiatric problems, and early death. Initially, NS was reported only in onchocerciasis-endemic regions in Tanzania, Uganda and South Sudan. Until recently, the cause of the syndrome was unknown. Therefore, no strategy for prevention and cure was possible. Our ERC project (NSETHIO) discovered that NS is only one of the clinical presentations of onchocerciasis associa",{"id":582,"funder":7,"programme":8,"title":583,"piName":10,"institution":584,"country":52,"year":13,"amount":585,"abstract":586},"cordis-european-research-council-award-737587","Multilingual work spaces for sign language users – An online portal driving social innovation","UNIVERSITY OF LANCASHIRE","€149,723","This project aims to pilot a social innovation by translating some of the findings of the ERC-funded MULTISIGN project (“Multilingual behaviours in sign language users”) into an online portal which promotes and facilitates transnational communication by deaf people through sign languages. The portal provides activities to users that increase their meta-linguistic awareness about the bi- and multilingual use of sign languages. Specifically, we will exploit research data and analyses by translatin",{"id":588,"funder":7,"programme":8,"title":589,"piName":10,"institution":590,"country":52,"year":13,"amount":21,"abstract":591},"cordis-european-research-council-award-754895","The International Register of Academic Job Categories. Facilitating Careers in the European Research Area","UNIVERSITY OF WARWICK","The Proof of Concept INTAC project will create a prototype of an online Register which systematically lists, explains and compares formal job categories and status positions of research- and teaching staff in 575 higher education institutions in France, Germany and Great Britain. It will set up the Register on a public multilingual platform and provide resources for career-relevant decision-making (such as career guidelines, CV templates, visualisation and mapping tools for career tracks and sta",{"id":593,"funder":7,"programme":8,"title":594,"piName":10,"institution":595,"country":596,"year":13,"amount":36,"abstract":597},"cordis-european-research-council-award-779985","Graphene as effective anti-fading agent for the protection of artworks","IDRYMA TECHNOLOGIAS KAI EREVNAS","EL","All art materials are prone to degradation; in particular, the introduction of new creative manufacturing techniques in the 20th century art has yielded artworks with short lifetime expectancy. Fading, yellowing and discolouration are the most common degradation effects that result from the exposition to UV and visible light and oxidizing agents. The result of the degradation is the irreversible alteration of the appearance of contemporary artworks, which is a patrimony of mankind. This PoC proj",{"id":599,"funder":7,"programme":8,"title":600,"piName":10,"institution":601,"country":20,"year":13,"amount":602,"abstract":603},"cordis-european-research-council-award-754795","Complementary Adhesive Coatings based on Molecular Association","UNIVERSIDAD AUTONOMA DE MADRID","€149,975","Adhesives constitute a potent and very broad technology, offering innovative solutions to a wide range of industries and providing craftsmen and private consumers with easy-to-use technically-advanced products. For every application in which two elements need to be fastened together, a specific adhesive can in principle be formulated. We aim at developing a novel adhesive technology, CompAd, that ultimately targets the commercialization of adhesive formulations for coating different surfaces, pr",{"id":605,"funder":7,"programme":8,"title":606,"piName":10,"institution":607,"country":12,"year":13,"amount":608,"abstract":609},"cordis-european-research-council-award-768527","BabyMinder: Automatic diagnosis of neurocognitive impairment in infants","ECOLE NORMALE SUPERIEURE","€149,780","Each year, millions of infants are born with neurodevelopment disorders resulting in cognitive deficits. Although infants are tested for their low-level (visual and auditory) abilities in the health care system, no standard tools exist for evaluating the development of cognitive functions, due to the absence of verbal report and explicit behaviour. Converging evidence now suggests that neural markers obtained from electroencephalographic (EEG) offer a valid approach for tracking the development ",{"id":611,"funder":7,"programme":8,"title":612,"piName":10,"institution":143,"country":31,"year":13,"amount":613,"abstract":614},"cordis-european-research-council-award-737545","A Wireless, Modular, Flexible, High-Density EMG Recording System","€149,994","Altered muscle activity might be co-responsible for chronic pain. Discomfort, ache and reduced mobility are, for example, associated in low back pain patients with dysfunctional activation of the spine musculature often leading to a vicious circle of overloading and inactivity. Analysing the activities of relevant muscles in real time could provide valuable feedback for new therapies. However, deriving from muscular activities pathological behaviour requires the use of a high-density electromyog",{"id":616,"funder":7,"programme":8,"title":617,"piName":10,"institution":618,"country":619,"year":13,"amount":21,"abstract":620},"cordis-european-research-council-award-755134","Intelligent Building Automation Diagnostics","UNIVERSITY OF CYPRUS","CY","The emergence of networked cyber-physical systems, in which sensor\u002Factuator networks are integrated with software algorithms, facilitates the development of advanced Building Management Systems (BMS) aimed at enhancing energy efficiency in buildings, which accounts for 40% of the energy consumption in the EU. When a fault arises in some of the components, or an unexpected event occurs in the building, this may lead to a serious degradation in performance or, even worse, to situations that would ",{"id":622,"funder":7,"programme":8,"title":623,"piName":10,"institution":624,"country":207,"year":13,"amount":625,"abstract":626},"cordis-european-research-council-award-737564","Adaptive Imaging Microscopy","TECHNISCHE UNIVERSITEIT DELFT","€149,998","The project has a goal of starting up a small business producing highly special customizable microscope systems for biomedical research. Microscopic imaging  is one of the major drivers of the progress in biomedical and life sciences. The   development of  novel  concepts,  addressing  the  challenges  of  advanced optical microscopy, represents the front line of scientific research.  Modern microscopes are not purely optical devices anymore. They have developed into complex integrated systems, ",{"id":628,"funder":7,"programme":8,"title":629,"piName":10,"institution":630,"country":52,"year":13,"amount":631,"abstract":632},"cordis-european-research-council-award-737638","Rapid crystallization design platform based on a novel stereo-imaging probe with anti-fouling system","LOUGHBOROUGH UNIVERSITY","€149,963","The aim of the project is to develop a novel low-cost intelligent crystallization visualization tool that enables the collection ofreal-time stereo (or combined visible and infrared) images as well as prevents probe fouling by using a specially designed anti-fouling control system. With the additional software interface, with efficient image analysis approaches incorporated in the crystallization process informatics systems, the tool will be the first low-cost, real-time and in situ intelligent ",{"id":634,"funder":7,"programme":8,"title":635,"piName":10,"institution":636,"country":265,"year":13,"amount":637,"abstract":638},"cordis-european-research-council-award-727306","Validation of an in vivo translational medicine approach for the treatment of diabetes and diabetes complications","KAROLINSKA INSTITUTET","€149,365","Validation of an in vivo translational medicine approach for the treatment of diabetes and diabetes complications To develop new drugs for treatment of diabetes, there is an immediate need for an in vivo approach allowing the assessment of β-cell function and survival in the living organism non-invasively, longitudinally and at single-cell resolution. We therefore transplant pancreatic islets into the anterior chamber of the eye (ACE) of mice for functional microscopic imaging. In the ACE islets",{"id":640,"funder":7,"programme":8,"title":641,"piName":10,"institution":224,"country":74,"year":13,"amount":21,"abstract":642},"cordis-european-research-council-award-754467","Nichoid: nanoengineered three-dimensional substrate for stem cell expansion","Mesenchymal stem cells (MSCs) raise a great interest for regenerative medicine for many clinical applications such as orthopaedic, plastic and reconstructive surgery, within autoimmune or degenerative disease treatment and as immune-suppressive agents in organ transplantation. In stem cell therapy, cells are injected in the patient after an extensive in vitro manipulation aimed at obtaining a sufficient cell number able to guarantee the therapeutic effect. Currently, stem cell manufacturing impl",{"id":644,"funder":7,"programme":8,"title":645,"piName":10,"institution":646,"country":242,"year":13,"amount":647,"abstract":648},"cordis-european-research-council-award-755445","Intelligent Control of Energy Storage for Smart Buildings and Grids","ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE","€149,720","The ICE project will demonstrate that energy regulation services can be provided to the smart grid in a technically reliable and financially lucrative fashion by utilizing a combination of smart commercial buildings and commercial batteries. The key to out-competing traditional solutions with such a service is the provision of energy storage at low capital and operational costs, which the ICE solution does via a novel hybrid storage concept that mixes the inexpensive virtual storage capacity, bu",{"id":650,"funder":7,"programme":8,"title":651,"piName":10,"institution":646,"country":242,"year":13,"amount":21,"abstract":652},"cordis-european-research-council-award-754375","Nematode-based screening technology for next-generation drug discovery","Alternative model organisms, such as worms or flies, are getting increasingly popular in the drug discovery field, since they are proving to be suitable for replacing mammals for several aspects of the screening tests in the pre-clinical phase. In this context, one of the most interesting models is a roundworm species, named Caenorhabditis elegans. Its microscopic size, however, hinders its actual use in the field, since the protocols for its maintenance and study still completely rely on manual",{"id":654,"funder":7,"programme":8,"title":655,"piName":10,"institution":646,"country":242,"year":13,"amount":58,"abstract":656},"cordis-european-research-council-award-727644","Commercializing soft wearable systems from a stretchable electronic material","SoWe represents a unique opportunity for the commercialisation of a unique stretchable electronic system that enables the design and manufacturing of large-area, high performance electronic skins. Prof. Lacour and her team, as part of the ERC project ESKIN, build upon a breakthrough innovation - an intrinsically stretchable metallization compatible with standard circuit fabrication and components assembly. These stretchable circuit boards will unlock the form-factor of existing planar and rigid ",{"id":658,"funder":7,"programme":8,"title":659,"piName":10,"institution":646,"country":242,"year":13,"amount":36,"abstract":660},"cordis-european-research-council-award-737562","Accurate cell signatures for the advancement of personalized medicine","Patient\u002Findividual specific cells, including induced pluripotent stem (iPS) cells will be crucial in defining tomorrow’s medicine owing to their uses in drug discovery, immunotherapy or cell therapy. These clinical applications require the utmost accurate and reliable identity and purity testing, however, the majority of cells stored worldwide fall short of a sufficient level of characterisation. This project aims at validatating and commercializing an innovative method of diagnostic and quality",{"id":662,"funder":7,"programme":8,"title":663,"piName":10,"institution":646,"country":242,"year":13,"amount":664,"abstract":665},"cordis-european-research-council-award-737639","Photonic Integrated Multi-Channel Telecommunication Optical frequency Comb","€149,987","Over the past years the Laboratory of Phonics and Quantum Measurements (LPQM) has developed a photonic chip that generates ultrashort pulses at 10-100 GHz mode spacing and is capable to spectrally cover all the telecommunication bands for high speed telecommunication testing applications, in contrast to existing products that usually only cover one band. Our fabrication base is a well-established semiconductor technology, expanded through innovative processes to cover the needs of optics develop",{"id":667,"funder":7,"programme":8,"title":668,"piName":10,"institution":646,"country":242,"year":13,"amount":669,"abstract":670},"cordis-european-research-council-award-754760","Novel water splitting catalysts for efficient alkaline electrolyzers","€149,959","Renewable energies such as solar and wind are intermittent and require efficient storage methods. One of the most promising methods for renewable energy storage is water splitting, which converts these energies into hydrogen fuel. Solar or wind-driven water splitting can be done using electrolyzers, and alkaline electrolyzers are potentially scalable because they do not use precious metal catalysts. However, current alkaline electrolyzers employ catalysts that have low efficiencies and are prone",{"id":672,"funder":7,"programme":8,"title":673,"piName":10,"institution":674,"country":52,"year":13,"amount":21,"abstract":675},"cordis-european-research-council-award-768101","Low Cost Material for Exhaust Catalysis (LowCat)","UNIVERSITY OF LEEDS","This project aims to develop a low cost catalyst to replace the Platinum Group Metals (PGMs) that are widely used in automotive exhaust catalysis. The ERC Advanced Grant project CODITA (project number 291332) is an investigation into the impacts of cosmic dust in planetary atmospheres. During the course of the project we have developed a novel laboratory synthesis of cosmic dust particle analogues. The kinetics of CO oxidation on this material were studied in order to model the heterogeneous oxi",{"id":677,"funder":7,"programme":8,"title":678,"piName":10,"institution":679,"country":172,"year":13,"amount":21,"abstract":680},"cordis-european-research-council-award-779689","Highly and Widely Effective, Water Stable, and Non Toxic Titanium-Phenolato-based Anticancer Chemotherapy","THE HEBREW UNIVERSITY OF JERUSALEM","Chemotherapy is the most common line of treatment for various cancer types, but it generally suffers from severe side effects. Cisplatin is a highly effective metallodrug employed in the clinic, limited by severe and irreversible nephro- and neurotoxicities and resistance development. Therefore, developing highly and widely effective chemotherapy that is non- or substantially less- toxic should impact immediately and significantly the welfare of society. The titanium metal is an attractive Pt al",{"id":682,"funder":7,"programme":8,"title":683,"piName":10,"institution":684,"country":20,"year":13,"amount":685,"abstract":686},"cordis-european-research-council-award-727264","Development of a ncRNA DNA Methylation Kit for Treatment Guidance in Cancer of Unknown Primary","FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE","€149,345","The innovative idea behind the EPIPHARM (EPIgenetics of PHARMacogenetics) project is to develop a package demonstrating the feasibility of a high-throughput tool for epigenotyping Cancer of Unknown Primary (CUP) to identify a drug sensitivity fingerprint based in the DNA methylation profile of non-coding RNA (ncRNA) loci. CUPs are a heterogeneous group of cancers defined by the presence of metastatic disease with no identified primary tumor at presentation. The CUP outcome is extremely poor with",{"id":688,"funder":7,"programme":8,"title":689,"piName":10,"institution":148,"country":12,"year":13,"amount":21,"abstract":690},"cordis-european-research-council-award-727334","Software Components for Robust Geometry Processing","The TITANIUM proposal aims to develop a software demonstrator for geometry processing and 3D urban modeling, in order to facilitate the pre-commercialization of novel software components for the Computational Geometry Algorithms Library. The proposed demonstrator will include novel approaches resulting from the ERC-funded IRON project (‘Robust Geometry Processing’, StG-2010-257474), which are illustrated by publications presented at premier conferences in our field (receiving two best paper awar",{"id":692,"funder":7,"programme":8,"title":693,"piName":10,"institution":694,"country":52,"year":13,"amount":695,"abstract":696},"cordis-european-research-council-award-754615","Highly Efficient Photoemitters for Light-Emitting Diodes Based on Intramolecular Rotation","UNIVERSITY OF EAST ANGLIA","€149,115","We have discovered a new class of photo- and electroluminescent complexes which are suitable for incorporation into organic light emitting diodes (OLEDs) and which give up to 100% internal quantum yield. The new compounds are particularly suitable for the fabrication of OLEDs via cheap solution-processing techniques and have so far reached 27% external quantum efficiency, a record for any solution-processed device. The new complexes have a linear, rotationally flexible structure, and it is this ",{"id":698,"funder":7,"programme":8,"title":699,"piName":10,"institution":51,"country":52,"year":13,"amount":700,"abstract":701},"cordis-european-research-council-award-727292","Nano Impacts for Biomedical and Environmental Analysis","€149,989","NIBEA will turn the developments and understanding from NANOIMPACTS into real world analytical practice such that reliable analytical protocols are established, validated and demonstrated especially in the context of real world media (environmental, industrial, medical) providing an entirely new approach to nanoparticle analysis based on electrochemical measurements. NIBEA will provide a step change in comparison with the present state of the art since particles of much smaller size and of great",{"id":703,"funder":7,"programme":8,"title":704,"piName":10,"institution":259,"country":172,"year":13,"amount":21,"abstract":705},"cordis-european-research-council-award-727359","Biofoulant-repelling surfaces for catheters and other biomedical devices","The object of this proof of concept project is to modify the surfaces of biomedical devices intended for contact with human tissue, such as catheters, stents or contact lenses, to render them repellent to biofoulants, based on discoveries made in our current ERC project HydrationLube. This will render such surfaces, and the devices, far more resistant to health-threatening infections. Our ERC project demonstrated that boundary layers based on phosphatidylcholine (PC) lipids (in the form of lipos",{"id":707,"funder":7,"programme":8,"title":708,"piName":10,"institution":709,"country":12,"year":13,"amount":21,"abstract":710},"cordis-european-research-council-award-766820","Industrialization of software and libraries for crack propagation in material and structures using the Thick Level Set method","ECOLE CENTRALE DE NANTES","The understanding and the reliable prediction of material degradation, crack initiation and propagation is of vital importance in engineering. It allows the evaluation of product lifecycle and the criticality of exceptional loads. Also, it enables maintenance optimization in a wide range of industries (automotive, aircraft, nuclear…).  Thanks to the ERC “XLS” grant, a new approach coined TLS (“Thick Level Set”) was developed to simulate crack propagation from sane material to critical rupture. T",{"id":712,"funder":7,"programme":8,"title":713,"piName":10,"institution":714,"country":160,"year":13,"amount":715,"abstract":716},"cordis-european-research-council-award-754308","Challenging Hypertension Through Novel Medical Device Development","UNIVERSITY OF GALWAY","€149,954","Hypertension directly causes approximately 25% of heart attacks in Europe and, in its progressed form of cardiovascular disease, it is estimated to cause 42% of all deaths across Europe annually. Untreated hypertension is one of the primary contributors to a number of the medical conditions with the greatest burden of care, including stroke, dementia and kidney failure. One of the most promising avenues for the treatment of hypertension has been research into primary aldosteronism (PA). In the l",{"id":718,"funder":7,"programme":8,"title":719,"piName":10,"institution":720,"country":31,"year":13,"amount":21,"abstract":721},"cordis-european-research-council-award-768930","Scalable and efficient production of functionalized, high-performance solution-processable graphene-materials","TECHNISCHE UNIVERSITAET DRESDEN","The worldwide increasing need for resources and energy as well as the foreseeable depletion of fossil fuels has led scientists into a race towards finding cleaner, more efficient and sustainable technologies. Graphene is believed to be able to play a crucial role in these developments due to its outstanding properties like excellent conductivity, mechanical strength, flexibility and chemical stability. A possible large-scale application is foreseen in polymer composites, where next to increased ",{"id":723,"funder":7,"programme":8,"title":724,"piName":10,"institution":725,"country":178,"year":13,"amount":21,"abstract":726},"cordis-european-research-council-award-737596","A comparative clinical study of a stool-based versus a blood-based screening test for early detection of CRC","VIB VZW","Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer deaths in Europe and USA. Its incidence and difficult early-diagnosis make CRC a primary focus in the oncology community. Although colonoscopy is currently the most reliable clinical tool for precise detection of CRC, the invasive nature and the incurred cost have hampered the wide application of this procedure. On the other hand, the fecal occult blood test (FOBT) and the fecal immunoistoche",{"id":728,"funder":7,"programme":8,"title":729,"piName":10,"institution":679,"country":172,"year":13,"amount":21,"abstract":730},"cordis-european-research-council-award-721317","TIGIT therapy for cancer treatment","Treating tumors with immune-related therapies is one of the most exciting and promising advancements made in the past decade. Cancer immunotherapy drugs have captured nearly 50% of the overall oncology drugs market. TIGIT is an important checkpoint inhibitory receptor discovered by our group in 2009. It is constitutively expressed by various immune cells and its expression is further increased on tumor infiltrating lymphocytes (TILs). TIGIT recognizes two main ligands, PVR and Nectin2 that are h",{"id":732,"funder":7,"programme":8,"title":733,"piName":10,"institution":522,"country":242,"year":13,"amount":21,"abstract":734},"cordis-european-research-council-award-768667","Carrier for Cure: tailored combination drug delivery solutions for oncology","Chemotherapy, often given in conjunction with other therapies is infamous for its off target associated side effects. Recent studies have shown that drugs combinations can act synergistically at certain ratios and are more effective and less toxic than single drug therapies. Despite promising in vitro results, combination drug therapy for Oncology has not been successfully translated to the clinic due to lack of efficient delivery systems that can maintain the desired synergistic drug concentrat",{"id":736,"funder":7,"programme":8,"title":737,"piName":10,"institution":259,"country":172,"year":13,"amount":21,"abstract":738},"cordis-european-research-council-award-751106","MRI diagnosis using a single-shot imaging technique with unprecedented robustness to field inhomogeneities","This project seeks to exploit cross-term spatiotemporal encoding (xSPEN), a single-shot MRI modality that we introduced last year as part of our efforts to develop new ultrafast techniques in nuclear magnetic resonance. Besides delivering single-shot images in tens of milliseconds, xSPEN exhibits an unprecedented resilience to field inhomogeneities enabling it to access regions that have so far never been scanned by single-scan MRI. Over the last year we have confirmed this and further developed",{"id":740,"funder":7,"programme":8,"title":741,"piName":10,"institution":457,"country":207,"year":13,"amount":21,"abstract":742},"cordis-european-research-council-award-727597","Supramolecular hydrogels as local controlled drug delivery carriers","In recent years, macroscale drug delivery systems have been designed and investigated to spatiotemporally control the release of various bioactive agents and drugs at specific locations in the body.  Many of these macroscale drug delivery vehicles are based on hydrogels.  Depending on the location of application, and the temporal release kinetics, these hydrogel drug carriers need to be adjusted to the need of the application. Many of the currently available hydrogel systems do not have the capa",{"id":744,"funder":7,"programme":8,"title":745,"piName":10,"institution":746,"country":20,"year":13,"amount":747,"abstract":748},"cordis-european-research-council-award-727297","Making Complex Gas Analytics Friendly and Available ASAP","UNIVERSITAT DE BARCELONA","€149,962","GasApp aims at bringing the capability to detect gases to every existing smartphone in just a few months. Carrying out a gas measurement will be as simple as taking a snapshot with the phone’s camera. Technically, we will rely on colorimetry methods to turn the presence of chemical substances into colour changes. GasApp wants to take a fast track towards accurate, highly specific, and highly accessible measurements by rethinking the concept of “ubiquitous sensing”. Instead of developing new comp",{"id":750,"funder":7,"programme":8,"title":751,"piName":10,"institution":674,"country":52,"year":13,"amount":752,"abstract":753},"cordis-european-research-council-award-727541","Development of a Terahertz Self-Mixing Imaging System","€149,580","The ERC Advanced grant ‘TOSCA’ (grant number: 247375) focussed on the development of terahertz (THz) frequency science and technology, and in particular, investigated the electronic and photonic engineering of THz quantum cascade lasers (QCLs), and the underlying physics of these sophisticated devices.  This Proof of Concept grant (THEMIS) builds on this pioneering research, and in particular on our breakthrough developments in QCL self-mixing imaging. We will increase the technology readiness l",{"id":755,"funder":7,"programme":8,"title":756,"piName":10,"institution":457,"country":207,"year":13,"amount":102,"abstract":757},"cordis-european-research-council-award-755471","Therapeutic antibody drug monitoring using bioluminescent sensors proteins and a smartphone","Therapeutic antibodies represent an important class of newly introduced drugs and have been particularly successful in cancer therapy and the treatment of inflammatory diseases. The clearance rates of therapeutic antibodies are known to differ per individual and correlate with survival rates. Being able to define a personalized dose per patient based on continuous monitoring of therapeutic antibody levels would therefore be beneficial both for the individual patient and for the hospital’s budget",{"id":759,"funder":7,"programme":8,"title":760,"piName":10,"institution":345,"country":207,"year":13,"amount":346,"abstract":761},"cordis-european-research-council-award-768914","Real-time tracking of whisker kinematics for closed-loop neuroscientific experiments","We study the sensorimotor adaptation in the cerebellum with the whiskers of the mouse as a model system. The whiskers are a sophisticated sensorimotor apparatus with which the mouse actively profiles its immediate 3D environment by swiftly whisking. To estimate distances, orientation and texture of its surroundings, the mouse uses a ‘maximum contact, minimum penetration’ scheme, with sensorimotor decisions taking place within as little as 10 ms. This scheme imposes the main experimental challeng",{"id":763,"funder":7,"programme":8,"title":764,"piName":10,"institution":765,"country":12,"year":13,"amount":107,"abstract":766},"cordis-european-research-council-award-737546","PIK3CA inhibition in patients with the CLOVES syndrome","UNIVERSITE PARIS CITE","The Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, Scoliosis\u002FSkeletal and Spinal (CLOVES) syndrome is a genetic disorder due to a gain of function mutation of the PIK3CA in a mosaic fashion. This rare condition is associated with severe deformation and poor survival. We identified a new drug able to dramatically improve the outcome of patients with this rare disease. The purpose of the Proof of Concept grant is to better understand the molecular effect of this drug and",{"id":768,"funder":7,"programme":8,"title":769,"piName":10,"institution":601,"country":20,"year":13,"amount":21,"abstract":770},"cordis-european-research-council-award-780284","Imaging-XChem: A computational package for ultrafast electronic control in chemistry","Commercial quantum-chemistry computational packages are widely used in science and chemical industry to predict the properties and reactivity of molecules and to design new compounds and drugs that can eventually be synthesized in the laboratory. The software developed in the framework of the ERC AdG project XCHEM is aimed at providing a full quantum mechanical description of a large variety of chemical processes that cannot be addressed by standard quantum chemistry packages, namely those proce",{"id":772,"funder":7,"programme":8,"title":773,"piName":10,"institution":774,"country":265,"year":13,"amount":10,"abstract":775},"cordis-european-research-council-award-780659","Identification of novel inhibitors to prevent microbial production of pro-diabetic metabolites","GOETEBORGS UNIVERSITET","The gut microbiota has been associated with metabolic diseases, such as type 2 diabetes. In my ERC consolidator award we demonstrated that the gut microbiota is altered following bariatric surgery and that the altered microbiota may be directly linked to some of the metabolic improvements observed following surgery. Interestingly, improved metabolism was associated with altered metabolite production capacity from the microbiota and we observed that a metabolite, imidazole propionate, was reduced",{"id":777,"funder":7,"programme":8,"title":778,"piName":10,"institution":779,"country":52,"year":13,"amount":780,"abstract":781},"cordis-european-research-council-award-767173","New thermo-regulating paints based on nanoencapsulation of phase-change materials","THE UNIVERSITY OF LIVERPOOL","€149,893","The proposal is focused on the innovation potential of thermo-regulating paints for effective thermal insulation and controlled release\u002Fuptake of the thermal energy in buildings. These thermo-regulating paints are based on the energy nanocapsules with encapsulated phase change materials, which are under development in ERC 2014 Consolidator grant No. 647969 ENERCAPSULE, and current commercial paint formulations. The addition of the energy nanocapsules able to store and release heat will provide c",{"id":783,"funder":7,"programme":8,"title":784,"piName":10,"institution":785,"country":74,"year":13,"amount":21,"abstract":786},"cordis-european-research-council-award-727313","Evaluation of commercial potential of a low-cost kit based on DNA-nanoswitches for the single-step measurement of diagnostic antibodies","UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA","Antibodies are among the most widely monitored class of diagnostic biomarkers. Immunoassays market now covers about 1\u002F3 of the global market of in-vitro diagnostics (about $50 billion). However, current methods for the detection of diagnostic antibodies are either qualitative or require cumbersome, resource-intensive laboratory procedures that need hours to provide clinicians with diagnostic information. A new method for fast and low-cost detection of antibodies will have a strong economic impac",{"id":788,"funder":7,"programme":8,"title":789,"piName":10,"institution":790,"country":172,"year":13,"amount":791,"abstract":792},"cordis-european-research-council-award-779896","Voltage Nanosensors for Applications in Neuroscience","BAR ILAN UNIVERSITY","€149,566","To understand how the brain works, tools need to be developed to allow the investigation of interactions between individual neurons. Towards this goal, We developed voltage sensing nanoparticles (vsNPs) in the shape of nanorods (vsNRs) that self-insert into the cell membrane and could optically record, non-invasively, action potentials (APs) at the single-particle and nanoscale level, at multiple sites, in a large field-of-view. The proposed nanosensors have unique advantages not offered by othe",{"id":794,"funder":7,"programme":8,"title":795,"piName":10,"institution":796,"country":797,"year":13,"amount":184,"abstract":798},"cordis-european-research-council-award-767882","CodeSphere - Discovering Therapeutic Nanoparticles by Molecular Encoding","DANMARKS TEKNISKE UNIVERSITET","DK","There is currently no high-throughput method to efficiently identify and optimize nanoparticle delivery of therapeutic relevant cargo such as drugs or mRNA before progression through costly clinical development.  This is in stark contrast to the situation for small molecules and antibodies, where screening technologies such as high-throughput small molecule screening and phage display in the last decades have proven very successful to aid and drive drug discovery and development.Our project ‘Cod",{"id":800,"funder":7,"programme":8,"title":801,"piName":10,"institution":802,"country":12,"year":13,"amount":21,"abstract":803},"cordis-european-research-council-award-755347","Precision confiner for mechanical cell activation","INSTITUT CURIE","In tissues, cells have their physical space constrained by neighbouring cells and extracellular matrix. In the PROMICO ERC project, our team proposed to specifically address the effect of physical confinement on normal and cancer cells that are dividing and migrating, using new pathophysiologically relevant in vitro approaches based on innovative micro-fabrication techniques. One of the devices we developed was meant to quantitatively control two key parameters of the cell environment: its geome",{"id":805,"funder":7,"programme":8,"title":806,"piName":10,"institution":807,"country":808,"year":13,"amount":21,"abstract":809},"cordis-european-research-council-award-737472","Pre-Commercialisation of Sound Recognition for Surveillance Applications","TAMPEREEN KORKEAKOULUSAATIO SR","FI","Audio communication is a major tool for businesses to maintain their competitiveness in the global market. This market is expected to treble by 2020 to $2.145 billion and creates a great demand for novel ideas, such as acoustic pattern recognition technologies. Similarly, the explosion in big data is calling for new data classification methods for improved data indexation and real-time monitoring of the data streams. We have developed acoustic pattern classification methods that are able to dete",{"id":811,"funder":7,"programme":8,"title":812,"piName":10,"institution":813,"country":20,"year":13,"amount":21,"abstract":814},"cordis-european-research-council-award-737559","Targeting infertility associated to defective Insulin\u002FIGF-1 signalling","UNIVERSIDAD PABLO DE OLAVIDE","Fertility decline is the largest contributor to population ageing in the world today, and infertility negatively impacts on the mental a social wellness of the population affected. One of the causes of birth rate tumbling is the trend of later motherhood in modern societies and the infertility associated to diabetes and polycystic ovary syndrome (PCOS). PCOS is the leading cause for ovulatory infertility, being the most common endocrine and metabolic disorder, affecting women in reproductive age",{"id":816,"funder":7,"programme":8,"title":817,"piName":10,"institution":818,"country":52,"year":13,"amount":503,"abstract":819},"cordis-european-research-council-award-754994","Gene Editing as Therapeutic Strategy for C9ORF72 Linked ALS\u002FFTD","THE UNIVERSITY OF SHEFFIELD","Expansion of a hexanucleotide repeat G4C2 in the non-coding region of chromosome 9 open reading frame 72 (C9orf72) is the most common genetic cause for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is a fatal condition characterized by progressive motor deficits, degeneration of upper and lower motor neurons (MNs) and death from neuromuscular respiratory failure in the majority of afflicted individuals within 3-5 years. Currently, the economic burden of care and trea",{"id":821,"funder":7,"programme":8,"title":822,"piName":10,"institution":823,"country":596,"year":13,"amount":21,"abstract":824},"cordis-european-research-council-award-755284","Assessing compounds targeting DNA replication licensing complexes as anti-tumor agents","PANEPISTIMIO PATRON","Cancer is a major clinical, societal and economic burden worldwide and development of novel anti-cancer therapies constitutes a major investment of public and private funds. Despite intense research over decades however, which has led to a much improved understanding of cancer biology, cancer treatment remains a challenge. This is to a large extent due to the genetic heterogeneity of cancer and the ability of cancer cells to escape treatment by constantly undergoing further genetic alterations. ",{"id":826,"funder":7,"programme":8,"title":827,"piName":10,"institution":545,"country":207,"year":13,"amount":21,"abstract":828},"cordis-european-research-council-award-780004","Precise array of proton selective nanopores in 2D atomically thin membranes","Direct methanol fuel cells (DMFCs) are devices expected to power future micro and portable electronic devices as well as vehicles. The lack of efficient proton exchange membranes, however, still prevents the development and application of DMFCs. Of paramount importance is ion selectivity and fast transmembrane transport, for which nanoporous two-dimensional membranes offer the prospect of enhanced fuel cell performance. Several chemical and physical limitations have so far prohibited the wide us",{"id":830,"funder":7,"programme":8,"title":831,"piName":10,"institution":725,"country":178,"year":13,"amount":21,"abstract":832},"cordis-european-research-council-award-766811","employing protein aggregation as an antibacterial design strategy","Antibiotic resistance is increasing globally at such a pace that many experts fear the dawn of the post-antibiotic era if we fail to meet the urgent need for novel therapeutics. We evaluated if the working hypothesis of the MANGO ERC project that protein aggregation is driven by sequence specific interactions can be exploited to generate aggregates that are specifically toxic to bacteria without affecting mammalian cells. In particular we examined if peptides encoding aggregation-prone sequence ",{"id":834,"funder":7,"programme":8,"title":835,"piName":10,"institution":836,"country":31,"year":13,"amount":837,"abstract":838},"cordis-european-research-council-award-754949","Blended Learning Course for Police Students: Death Notification with Responsibility","UNIVERSITAT KONSTANZ","€147,000","The aim of the proposed transfer project is to develop the blended learning course „Death Notification with Responsibility“ (DNR) for police officers. In situations of unnatural death (accidents, suicides, terror attacks or other forms of violence), police officers have to deliver a death notification to the family members of the deceased. Unnatural death is the worst possible message to be delivered. It will change the lives of those informed decisively and will remain in their memories forever",{"id":840,"funder":7,"programme":8,"title":841,"piName":10,"institution":842,"country":31,"year":13,"amount":843,"abstract":844},"cordis-european-research-council-award-737621","Structural Visualization of Medieval Manuscripts","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€149,150","In the 21st-century world of manuscript studies there is a gold rush for digitalization. More and more medieval manuscripts are becoming available in digital format. This opens up entirely new vistas of understanding both for the interested public and for academic research. However, the availability of digitized images is not sufficient in itself, because a medieval manuscript is more than just a series of pictures. In order to understand its diachronic dimension (its development over the centur",{"id":846,"funder":7,"programme":8,"title":847,"piName":10,"institution":848,"country":52,"year":13,"amount":849,"abstract":850},"cordis-european-research-council-award-779822","Functional magnetic materials for biomedical applications","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€149,997","A range of new medical therapies and diagnostics based on magnetic nanomaterials have recently been proposed.  These include cancer therapies, stem cell therapies, microfluidic diagnostic devices and immunoassays.  However, very few biotechnology magnetic nanomaterials are currently available commercially; most investigators fabricate their own.  This is a serious limitation to the development of this emerging area within nanomedicine. This proposal aims to transfer a number of magnetic nanomate",{"id":852,"funder":7,"programme":8,"title":853,"piName":10,"institution":854,"country":52,"year":13,"amount":855,"abstract":856},"cordis-european-research-council-award-737534","A next-generation platform for catalysing pre-clinical development of drugs against Alzheimer’s and other degenerative diseases of old-age","UNIVERSITY OF DUNDEE","€149,961","Degenerative diseases of old age, including cardiovascular diseases, type II diabetes, and chronic respiratory conditions, have emerged as the major causes of death in EU countries. Of special concern are neurodegenerative conditions including Alzheimer’s and Parkinson’s, which have been described as the greatest unmet need facing modern medicine. Developing new therapies to slow, halt, or reverse these pathologies is regarded as a key element in addressing this global health priority. No such t",{"id":858,"funder":7,"programme":8,"title":859,"piName":10,"institution":860,"country":31,"year":13,"amount":21,"abstract":861},"cordis-european-research-council-award-767234","Bifunctional and regeneratively active biomaterial: Towards an ultimate solution for osteoarthritis treatment","UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ","Osteoarthritis (OA) is the most common form of arthritis of the joints, affecting over 70 million EU citizens. At present, no cure for OA is available; only symptomatic therapies may help to ameliorate this painful disorder. OA affects the integrity of the cartilage and progresses to an increased damage in its surrounding tissues, inclusive bone, and to inflammation of the synovial tissue. The latter reaction is caused by an accumulation of bone splinters. The therapy of choice would be – if ava",{"id":863,"funder":7,"programme":8,"title":864,"piName":10,"institution":842,"country":31,"year":13,"amount":865,"abstract":866},"cordis-european-research-council-award-737552","A clinical phonetics laboratory service (PhonLab): diagnostics of speech impairment via the web","€146,130","In line with present trends to expand eHealth in medical care, this project‘s objective is to provide a commercial web-based service for the automatic diagnosis of impaired speech, given a sample of the client’s speech transmitted over the internet. Currently, speech therapists are required to diagnose speech impairments from only a pen and paper analysis of transcriptions based on auditory impressions. The main advantage of the innovative approach of this project is to quantify the production o",{"id":868,"funder":7,"programme":8,"title":869,"piName":10,"institution":870,"country":12,"year":13,"amount":21,"abstract":871},"cordis-european-research-council-award-737604","Fast, Digital  Adaptive Personalized Radiotherapy","THERAPANACEA","TheraPanacea seeks to provide digital, innovative, patient-specific, and adaptive radiotherapy treatment planning system. Our objectives are the following: (i) improve the quality of treatment towards increasing the survival rate, while (ii) reducing the side effects towards diminishing the disastrous long term radiation impact and (iii) improving the efficiency of device use towards increasing significantly the number of patients being treated.",{"id":873,"funder":7,"programme":8,"title":874,"piName":10,"institution":875,"country":178,"year":13,"amount":876,"abstract":877},"cordis-european-research-council-award-727695","Enhanced Place Finding (EPF) of TB transmission hotspots","INSTITUUT VOOR TROPISCHE GENEESKUNDE","€149,783","TB is transmitted via person-to-person aerosols. Recent studies suggests that in TB endemic areas up to 70% of transmission events take place outside the household in public places. Moreover, TB transmission is unequally spatially distributed and occurs in transmission hotspot areas. Mathematical models consequently demonstrated that identifying hotspots and blocking within-hotspot-transmission through targeted public health interventions will be the most efficient way of lowering the TB burden.",{"id":879,"funder":7,"programme":8,"title":880,"piName":10,"institution":218,"country":52,"year":13,"amount":881,"abstract":882},"cordis-european-research-council-award-727626","An ultra compact greenhouse gas remote sensing system for ranges between 500 and 2000 m","€149,817","The CO2Volc project (ERC n.279802) has produced an active remote sensing instrument based on the differential absorption LIDAR principle, called CO2DIAL. It is designed to measure column averaged CO2 concentrations for path lengths between 500 and 2000 m. A key advantage over other open-path techniques is that no retroreflector or separate active source is required for fence-line monitoring. It therefore fills a key operational gap in CO2 sensing technologies. In addition, through a laser replac",{"id":884,"funder":7,"programme":8,"title":885,"piName":10,"institution":171,"country":172,"year":13,"amount":21,"abstract":886},"cordis-european-research-council-award-727606","Hydrogen production by membrane free chemical – electrochemical systems","Until recently it was believed to be impossible to produce hydrogen through water electrolysis systems, without an electrochemical oxygen production process and without a membrane. However, in the past few years, our team was able to develop a new technological configuration which divides the water splitting process into two phases : (1) an efficient electrochemical hydrogen production followed by a (2) spontaneous chemical oxygen production phase. By eliminating the inefficient electrochemical ",{"id":888,"funder":7,"programme":8,"title":889,"piName":10,"institution":259,"country":172,"year":13,"amount":21,"abstract":890},"cordis-european-research-council-award-764203","Producing hydrogen by water splitting","This proposal describes a plan to prove the role of electrons’ spin in the photocatalyzed oxidation of water; reaction of two water molecules to form two hydrogen molecules and a single oxygen molecule in its triplet ground state. We found that the catalyst performance is affected by its chiral symmetry, or lack thereof. It is well known that the electrochemical and photoelectrochemical splitting of water requires a high overpotential and that it can be changed by the choice of catalyst; however",{"id":892,"funder":7,"programme":8,"title":893,"piName":10,"institution":894,"country":178,"year":13,"amount":21,"abstract":895},"cordis-european-research-council-award-780540","CANITEST: Proof-Of-Concept of a PCR test designed to identify the dogs carrying the more virulent strains of Capnocytophaga canimorsus","UNIVERSITE DE NAMUR","The idea to be taken as proof of concept is drawn from the ERC Advanced grant N°293605-CAPCAN (2012-2016). This grant aimed at understanding the molecular and genetic bases of the dramatic human infections caused by Capnocytophaga canimorsus. One of the questions that we addressed in the frame of CAPCAN is why are there so few cases of human infections while so many dogs carry C. canimorsus?  In other words, are all C. canimorsus strains equally dangerous and, if not, could we prevent the diseas",{"id":897,"funder":7,"programme":8,"title":898,"piName":10,"institution":899,"country":74,"year":13,"amount":21,"abstract":900},"cordis-european-research-council-award-727832","Open Correspondence Publishing and Visualization Platform.","UNIVERSITA IUAV DI VENEZIA","In Humanities, written correspondence is a fundamental object of study. The current IT revolution provides means for reassembling and disseminating this precious literary heritage for the first time, while at the same time fostering new forms of scholarly cooperation. As letters create links between people, the value of documents and data increases when different corpora of written correspondences are interconnected and linked. Despite the strong need for common standards and common tools to exp",{"id":902,"funder":7,"programme":8,"title":903,"piName":10,"institution":904,"country":195,"year":13,"amount":905,"abstract":906},"cordis-european-research-council-award-737549","Eliminating turbulence in oil pipelines","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","€149,830","Proof of Concept TURBO FLOWVirtually all pipeline flows are highly turbulent. What is probably less well known is that the major part of the frictional losses in pipelines is caused by turbulence. Already at moderate speeds turbulence is responsible for a 50% drag increase while at high speeds (i.e. high Reynolds numbers) this figure can easily increase to 99%. Annual global pumping costs for oil pipelines alone amount to tens of billions of Euros. If instead the fluid could be maintained in the",{"id":908,"funder":7,"programme":8,"title":909,"piName":10,"institution":595,"country":596,"year":13,"amount":21,"abstract":910},"cordis-european-research-council-award-737599","A Drug Discovery and Target Identification Screening Platform for Age-Associated Neurodegenerative Disorders","Battling human neurodegenerative pathologies, and their pervasive societal impact, is a global multi-billion Euro enterprise. Ageing is universally associated with marked decrease of neuronal function and higher susceptibility to neurodegeneration. In human populations, this is manifested as an ever-increasing prevalence of devastating neurodegenerative conditions, including Alzheimer’s and Parkinson’s disease, stroke, several ataxias, and other types of dementia. Development of therapeutic inte",{"id":912,"funder":7,"programme":8,"title":913,"piName":10,"institution":914,"country":31,"year":13,"amount":915,"abstract":916},"cordis-european-research-council-award-727726","SMALL MOLECULES TO TREAT METABOLIC SYNDROME","MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)","€149,948","SMALL MOLECULES TO TREAT METABOLIC SYNDROMEMetabolic Syndrome (MS) is defined as a cluster of inter-related symptoms including central obesity, insulin resistance, dyslipidemia, and hypertension that promote the development of type 2 diabetes mellitus, cardiovascular diseases and certain cancers. In this project a pharmacological strategy will be developed that could alleviate the vicious circle of hyperglycemia (elevated blood glucose) and elevated insulin observed in metabolic syndrome that ac",{"id":918,"funder":7,"programme":8,"title":919,"piName":10,"institution":259,"country":172,"year":13,"amount":21,"abstract":920},"cordis-european-research-council-award-754282","ImmuNogenomics TArgeting Cancer","Melanoma is the most aggressive, treatment-resistant and lethal type of skin cancer. Its increasing incidence worldwide emphasizes the need for new treatment strategies. Major recent breakthroughs in melanoma therapy have highlighted the role of immune T cell-mediated responses against tumor cells, showing that immune-system recognition of neo-antigens on cancer cells serves as a distinctive immunological signature. However, current strategies to identify neo-antigens are biased, costly and time",{"id":922,"funder":7,"programme":8,"title":923,"piName":10,"institution":924,"country":31,"year":13,"amount":14,"abstract":925},"cordis-european-research-council-award-755466","Magnetic Resonance Shimming Applications with Near-magnet Equipment","UNIVERSITAETSKLINIKUM FREIBURG","Magnetic resonance (MR) imaging and spectroscopy critically relies on the homogeneity of the main field. Despite of the best technological efforts magnetic field in MR examinations cannot be made homogeneous due to the presence of the object of investigation – the human or an animal – in the magnet. Heterogeneous and unique distribution of tissues with their characteristic magnetic susceptibilities requires the process of field homogenization, termed shimming, to be performed on a subject-by-sub",{"id":927,"funder":7,"programme":8,"title":928,"piName":10,"institution":171,"country":172,"year":13,"amount":21,"abstract":929},"cordis-european-research-council-award-779754","Autonomous Nanosatellite-Clusters Control, Coordination and Communication Software","Coordinated operation of clusters of nanosatellites can potentially revolutionize the space sector; however, until recently, performing long-term satellite cluster flight was thought to be impractical, since existing orbital control methods required too much fuel. During the FADER ERC Starting Grant, our team was able to develop autonomous cluster flight algorithms capable of preserving the relative geometry and communication links among satellites in a cluster for mission lifetimes exceeding a ",{"id":931,"funder":7,"programme":8,"title":932,"piName":10,"institution":802,"country":12,"year":13,"amount":21,"abstract":933},"cordis-european-research-council-award-727408","Preclinical validation of a novel immunogenic composition to stimulate innate immunity","Immunotherapy is a promising approach to treat cancer and infectious diseases, but innovative approaches are required.The cGAS-cGAMP-STING pathway can induce a potent immune response against viruses. It is also implicated in antitumoral immune responses that are effective. We have recently discovered that the small second messenger cGAMP can be packaged by viruses to stimulate immunity in target cells. We have developed methods to produce non-infectious virus-like particles containing cGAMP (cGA",{"id":935,"funder":7,"programme":8,"title":936,"piName":10,"institution":937,"country":938,"year":13,"amount":21,"abstract":939},"cordis-european-research-council-award-764332","Neuroimmune activation as a novel therapeutic approach for IBD","FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD","PT","NeurIMM has been designed to investigate the commercial and technical viability of a novel, targeted therapy for Inflammatory Bowel Disease (IBD), based on a recently uncovered signaling axis between intestinal type 3 innate lymphoid cells (ILC3s) and enteric glial cells. This discovery by the team of Prof. Henrique Veiga-Fernandes in the ERC CoG grant 647274 ‘GliaInnateSensing’ was recently published in Nature (Ibiza et al, Nature 2016). NeurIMM proposes the use of a glial cell-derived immunomo",{"id":941,"funder":7,"programme":8,"title":942,"piName":10,"institution":943,"country":74,"year":13,"amount":21,"abstract":944},"cordis-european-research-council-award-727261","Integrated Smart Device for Emergency Management","POLITECNICO DI TORINO","The project IDEAL SENSOR is developing a wearable wrist band device and a customized structural health monitoring (SHM) system for managing emergencies.  The proposed system provides a comprehensive solution for indoor localization, healthcare monitoring, and other general purpose services (fitness, entertainment, health, etc.).  Moreover, an infrastructure based on the structural health monitoring will be developed which include all the functionality of standard Structural Health Monitoring (SH",{"id":946,"funder":7,"programme":8,"title":947,"piName":10,"institution":948,"country":31,"year":13,"amount":21,"abstract":949},"cordis-european-research-council-award-768584","All-electrical analytic platform for digital fluidics","HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF EV","Prospective biosensing technologies will need to tackle the grand challenges arising from the global demographic changes. Among the most crucial tasks is the monitoring of food and environmental quality as well as the medical diagnosis. Digital fluidics offers vast advantages in performing these tasks relying on tiny containers with reacting biochemical species and allowing massively parallelized assays and high throughput screening using optical detection approaches. I envision that adding not-",{"id":951,"funder":7,"programme":8,"title":952,"piName":10,"institution":848,"country":52,"year":13,"amount":631,"abstract":953},"cordis-european-research-council-award-737627","Aligned Roll-to-Roll Shear Coating of Nanotubes","Carbon Nanotubes (CNTs) are considered to be one of 21st century’s most promising materials and over the past decade, tremendous scientific advances have been achieved in the synthesis and processing of these materials. However, the uptake of CNTs by high-tech industry is hampered by a lack of high-throughput processes to structure CNTs into aligned and densely packed assemblies. This is key to fabricate next generation CNT devices, and to date, the CNT community is still struggling to achieve t",{"id":955,"funder":7,"programme":8,"title":956,"piName":10,"institution":957,"country":808,"year":13,"amount":21,"abstract":958},"cordis-european-research-council-award-780041","Transparent and Flexible Li-Organic 3D Thin-Film Microbattery","AALTO KORKEAKOULUSAATIO SR","In this Proof-of-Concept project we will demonstrate the practical feasibility of a fundamentally novel transparent andflexible Li-organic thin-film microbattery. The strong basis for the project is the new hybrid Li-organic electrode materialsdiscovered in the PI's ERC Advanced Grant Project “Molecular-Layer-Engineered Inorganic-Organic Hybrid Materials(LAYERENG-HYBMAT)”. These hybrid thin-film materials are fabricated by the combined atomic\u002Fmolecular layer deposition(ALD\u002FMLD) technique which u",{"id":960,"funder":7,"programme":8,"title":961,"piName":10,"institution":522,"country":242,"year":13,"amount":962,"abstract":963},"cordis-european-research-council-award-768610","Automated detection of damage to buildings","€143,750","Hail and storm damages represent the most often occurring cases for building insurance companies. Currently, the damage is estimated by an insurance expert, visiting the damaged building and drafting a report. Researchers at the Computer Vision Lab at ETH Zurich joined forces with business and sales people, spinning out the company Casalva, to strongly reduce such costs via automated image analysis. The idea is that the insurers’ clients upload photos of the damages, which will then be analyzed ",{"id":965,"funder":7,"programme":8,"title":966,"piName":10,"institution":259,"country":172,"year":13,"amount":21,"abstract":967},"cordis-european-research-council-award-692945","FORMAT: a novel medium FOr Revolutionizing stem cell MAnufacturing Technologies","One of the greatest challenges facing society is treating patients afflicted with degenerative and age-related disorders, such as multiple sclerosis, Parkinson’s disease and diabetes. For all of these, stem cell therapy represents a novel treatment approach and a great hope for the millions of patients worldwide. In my ERC-funded research project, we successfully managed to generate Extracellular-signal-Regulated Kinases (ERK) signalling independent human naïve Pluripotent Stem Cells (PSCs), a n",{"id":969,"funder":7,"programme":8,"title":970,"piName":10,"institution":230,"country":52,"year":13,"amount":971,"abstract":972},"cordis-european-research-council-award-737539","Haptic micromanipulation system for low cost autonomous microinjection tasks","€149,982","The ability to handle and operate on cells is an emerging technology that will accelerate the development of novel cell-based therapies. By being able to modify donor cells in-vitro to fight disease more effectively and in volume will have paradigm shifting advances in a wide range of fields such as biotechnology, pharmacology, agriculture, oncology, genetics and embryology. As highlighted by the Innovate UK Cell Therapy Catapult, by 2017 the cell-based therapy manufacturing industry will be wor",{"id":974,"funder":7,"programme":8,"title":975,"piName":10,"institution":957,"country":808,"year":13,"amount":574,"abstract":976},"cordis-european-research-council-award-727542","Graphene Tunneling Accelerometer","The commercialization of existing tunneling accelerometers is hindered by their complex fabrication and long-term instability. Based on our results and expertise from the currently running ERC project, we propose an innovative design using graphene as the game-changing material for tunneling accelerometers.  The proposed graphene tunneling accelerometer has clear technical advantages, such as smaller size, wider bandwidth, simpler fabrication, and natural stability. A careful patent search indic",{"id":978,"funder":7,"programme":8,"title":979,"piName":10,"institution":980,"country":74,"year":13,"amount":981,"abstract":982},"cordis-european-research-council-award-737447","Photovoltaic with superior crack resistance","SCUOLA IMT (ISTITUZIONI, MERCATI, TECNOLOGIE) ALTI STUDI DI LUCCA","€149,500","Cracks in silicon solar cells composing photovoltaic (PV) modules are induced during production (soldering of busbars onto solar cells, other defects), transportation, installation and exposure to the environment. The economic impact of cracking in PV modules has been assessed in about 6 Euro\u002F(kWp year) due to the cost of repair\u002Fsubstitution and the missing production while cracks are not yet observable with the naked eye. This has a clear huge technological and economic impact on the market tha",{"id":984,"funder":7,"programme":8,"title":985,"piName":10,"institution":679,"country":172,"year":13,"amount":21,"abstract":986},"cordis-european-research-council-award-737590","A novel pharmaceutical treatment for nonalcoholic fatty liver disease","Development of anti-microRNA therapeutic for nonalcoholic fatty liver disease Nonalcoholic fatty liver disease (NAFLD) initiates with excessive accumulation of liver triglycerides and progresses to nonalcoholic steatohepatitis (NASH), cirrhosis and liver cancer while also modifying brain metabolism. However, NAFLD pathogenesis, the corresponding impact on the brain and the links between them, are poorly understood. In addition NAFLD is largely untreatable. We have discovered that excess microRNA",{"id":988,"funder":7,"programme":8,"title":989,"piName":10,"institution":990,"country":20,"year":13,"amount":102,"abstract":991},"cordis-european-research-council-award-755251","Late-stage catalytic carboxylation techniques with labelled carbon dioxide: new opportunities for radiolabelling","FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA","Absorption, distribution, metabolism and excretion´s studies (ADME) are essential for drug discovery and development, providing invaluable preclinical data to understand how the drug behaves in living organisms, thus allowing to make a decision on whether the drug should be terminated or advanced to the next step. At present, most of these studies are performed with a radiolabelled 14C-labelled version of the drug; unfortunately, current radiolabelling syntheses rely on lengthy-step sequences or",{"id":993,"funder":7,"programme":8,"title":994,"piName":10,"institution":402,"country":207,"year":13,"amount":21,"abstract":995},"cordis-european-research-council-award-768338","A biomechanically driven, patient specific pre-planning and surgical tool to optimize placement of a novel meniscus prosthesis","In this BioMechMeniscus project we will develop a workflow for optimal placement of a novel meniscus implant. The medial meniscus implant (named ‘Trammpolin’) has been developed using methods developed during the BioMechTools project such as 1) principle component analyses based on MRI-segmented image to assess the anatomical shape of the meniscus, 2) assessing sensitivity of cartilage stresses and implant strains on size and design-parameters using finite element techniques and 3) utilizing loa",{"id":997,"funder":7,"programme":8,"title":998,"piName":10,"institution":999,"country":74,"year":13,"amount":1000,"abstract":1001},"cordis-european-research-council-award-727536","A Soft Synergy-based Hand Prosthesis with Hybrid Control","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","€149,787","In the project “SoftHands” we have achieved not only a more thorough understanding of the organization and control of hands, but also a principled approach to taming the complexity of hand design. The original concept of “soft synergies” has underpinned the realization of radically new artificial hands: “SoftHands” have been demonstrated to be more adaptive and capable than most artificial hands, yet are simpler to control and more robust. One application of these ideas and technologies which st",{"id":1003,"funder":7,"programme":8,"title":1004,"piName":10,"institution":1005,"country":178,"year":13,"amount":837,"abstract":1006},"cordis-european-research-council-award-737610","NI2D: Software for nonlinear vibration analysis: From identification to design.","UNIVERSITE DE LIEGE","Nonlinear vibrations are a frequent occurrence in engineering structures and can originate from friction, contact, material laws and large displacements. Nonlinear phenomena are most often ignored or avoided in industry, because practitioners lack both a methodology and a software for properly addressing them.The objective of this ERC PoC is to provide companies active in aerospace, automotive and mechanical engineering with a solution for the analysis of nonlinear vibrations. Specifically, we a",{"id":1008,"funder":7,"programme":8,"title":1009,"piName":10,"institution":1010,"country":12,"year":13,"amount":21,"abstract":1011},"cordis-european-research-council-award-766936","ITO-free multi-coloured nanoscale engineered OLEDs for large-area flexible lighting and full-colour active-matrix displays","CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION","FlexNanoOLED aims at expanding the groundbreaking research developed within the ERC project SUPRAFUNCTION into a radically new and unprecedented technology to enable the fabrication of flexible ITO-free multi-coloured nanoscale engineered organic LEDs. In a recent breakthrough, we have developed a novel device architecture for optoelectronics which relies on a nanomesh scaffold and demonstrated its full potential by realising supramolecular nanowire photovoltaic devices with performances surpass",{"id":1013,"funder":7,"programme":8,"title":1014,"piName":10,"institution":1015,"country":797,"year":13,"amount":1016,"abstract":1017},"cordis-european-research-council-award-768783","GPCR Exploitation To Unlock the Power of Brown\u002FBeige Adipose Tissue","KOBENHAVNS UNIVERSITET","€149,986","Hundreds of millions of people suffer from obesity and diabetes worldwide. These diseases diminish both life quality and expectancy and new treatment strategies are desperately needed. One possible approach is to target the calorie-burning and glucose-consuming functions of brown and beige adipose tissue (B\u002FBAT). Previous attempts to harness the therapeutic potential of B\u002FBAT have largely focused on the β-adrenergic class of G protein-coupled receptors (GCPRs). Unfortunately, these methods are h",{"id":1019,"funder":7,"programme":8,"title":1020,"piName":10,"institution":89,"country":74,"year":13,"amount":21,"abstract":1021},"cordis-european-research-council-award-779751","IN VItro Cavitation Through UltraSound","Disorders of the central nervous system (CNS) contribute almost 800 billion euros in annual European healthcare costs. New compounds, effective in animal models, hardly work in humans, mostly due to the inability to cross the Brain Blood Barrier (BBB). In these conditions cost-effective tools to alter BBB and, more generally, endothelial layer permeability is desirable before proceeding to expensive and time-consuming animal studies. INVICTUS (IN VItro Cavitation Through UltraSound) originates w",{"id":1023,"funder":7,"programme":8,"title":1024,"piName":10,"institution":508,"country":207,"year":13,"amount":21,"abstract":1025},"cordis-european-research-council-award-727641","BioREAD; a Continuous Barrier Quality Monitoring System for Organs-on-Chip","Organs-on-chip are expected to play a crucial role in the pharmaceutical industry for drug development and study of organs and diseases. We propose the development of an electrical detector that enables simple, versatile and continuous quality monitoring of these devices and is essential for commercialization. Combined with recent advances in stem cell technology, Organ-on-Chips can be used to do drug screening on an individual level. Therefore it can serve as instrument for personalized medicin",{"id":1027,"funder":7,"programme":8,"title":1028,"piName":10,"institution":183,"country":52,"year":13,"amount":1029,"abstract":1030},"cordis-european-research-council-award-727774","Portable Characterisation of Sperm Motility","€139,986","Based on an ongoing ERC project on characterising and studying the motility of highly-idealised, model micro-swimmers, we have built and validated a first-generation portable prototype device for assaying accurately bull sperm motility. To move to a more advanced prototype requires integrated software and hardware development and the setting up of standard protocols to render the measurement procedure robust for non-expert operators. Such a device, with integrated hardware and software, for Port",{"id":1032,"funder":7,"programme":8,"title":1033,"piName":10,"institution":636,"country":265,"year":13,"amount":21,"abstract":1034},"cordis-european-research-council-award-755150","Novel viral therapy through targeting DNA repair","Natural epidemics and outbreaks of emerging infectious diseases are a growing problem internationally. RNA viruses remain under constant attention due to the recent Zika virus (ZIKV) outbreak with potential causal relationship with microcephaly of newly born babies and Ebola virus (EBOV) and Crimean-Congo hemorrhagic fever virus (CCHFV) causing life threatening hemorrhagic fever, demonstrating how zoonotic viruses pose a major global health concern. 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