[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-proof-of-concept-2018":3,"awarded-stats-erc-proof-of-concept":845},{"awarded":4,"total":844},[5,16,21,28,34,39,44,50,57,63,68,73,77,81,87,93,99,106,112,119,124,130,137,142,148,154,159,165,171,177,183,189,194,200,206,212,218,224,229,234,240,246,251,256,261,267,273,279,283,289,293,299,304,310,314,319,325,330,336,342,346,351,356,360,364,369,374,380,386,392,397,402,408,413,418,423,429,434,439,444,448,452,457,462,467,472,477,481,485,491,497,503,507,511,515,520,525,530,535,540,545,551,556,561,567,572,578,583,589,595,600,604,608,614,618,624,629,634,639,643,648,652,656,662,666,671,675,679,685,689,695,700,705,711,716,720,724,728,733,739,744,749,754,759,764,770,774,778,782,786,792,796,801,807,812,817,822,826,832,838],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-812844","European Research Council","ERC Proof of Concept","Gamut mapping technology based on vision models",null,"UNIVERSIDAD POMPEU FABRA","ES",2018,"€150,000","The color gamut of a display is the set of colors that it can reproduce: screens with wider gamuts are capable of presenting more vivid, intense colors. Different display technologies have different gamuts, from the narrow gamut of TV sets to the wide gamut of cinema and the ultra-wide gamut of laser projectors. Gamut mapping is the process of adapting the colors of an image to the gamut of the display where it is shown, and it is an essential process at every step of the imaging chain: cameras ",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":12,"year":13,"amount":14,"abstract":20},"cordis-european-research-council-award-754630","Light-engaged Accommodating IOL","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","Presbyopia, the age-related loss of the ability of the eye to focus near and far objects, affects 1.2 billion people in the world. While there are a number of corrections for presbyopia available (near and progressive spectacles, monovision or multifocal lenses) none of these restore the dynamic focusing capability of the young crystalline lens.  Replacing of the rigid crystalline lens in the aged eye by a shape-changing artificial lens able to respond an accommodative demand, therefore restorin",{"id":22,"funder":7,"programme":8,"title":23,"piName":10,"institution":24,"country":25,"year":13,"amount":26,"abstract":27},"cordis-european-research-council-award-812816","A novel universal influenza vaccine targeting epitopes of limited variability","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","UK","€149,297","The antigenic evolution of influenza is conventionally assumed to occur by ‘antigenic drift’ where new strains arise through the incremental addition of mutations in surface glycoproteins. However, the antigenic drift model can only explain the epidemiology and limited genetic diversity observed among influenza virus populations by imposing constraints on the mode and tempo of mutation. We have shown that an alternative model known as ‘antigenic thrift’ successfully models the epidemiology and g",{"id":29,"funder":7,"programme":8,"title":30,"piName":10,"institution":31,"country":25,"year":13,"amount":32,"abstract":33},"cordis-european-research-council-award-813242","Broadband Room-temperature Inexpensive & IndistinGuishable pHoTons","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€149,945","The primary objective of this proposal is to build the first cheap and technically simple source of bright single photon states that have the characteristics (including state purity, repetition rate) to power photonic quantum technologies. Photonic quantum simulators have not been able to break into the regime where they outperform classical simulators because of the intrinsically probabilistic character of the photon sources, which means that in most runs of the simulator, there is no output. B",{"id":35,"funder":7,"programme":8,"title":36,"piName":10,"institution":24,"country":25,"year":13,"amount":37,"abstract":38},"cordis-european-research-council-award-812998","Translating adaptive microscopes to the clinic for tissue analysis during surgery","€149,850","Optical microscopes are one of the key tools that that guide a surgeon during the most complicated surgeries and provide the necessary feedback. State-of-the-art confocal laser scanning microscopes and endoscopes provide the most reliable images for diagnostic purposes. However, they are not yet capable enough to be used intraoperatively for high-resolution fluorescence imaging in some of the most complicated surgeries. Ideally, the surgeon needs to see the tissue in three dimensions at cellular",{"id":40,"funder":7,"programme":8,"title":41,"piName":10,"institution":24,"country":25,"year":13,"amount":42,"abstract":43},"cordis-european-research-council-award-813152","Single Molecule Imaging Mass Spectrometry","€142,050","We aim to demonstrate the disruptive commercial and societal potential of interferometric scattering microscopy for mass spectrometry of single biomolecules in solution. The PoC grant will be used to produce a near-market ready prototype and implement the required software modifications expected of a commercial device, to demonstrate that the technology is sufficiently robust to warrant venture capital funding for our spin-out company. Our early discussions with both pharma and instrument manufa",{"id":45,"funder":7,"programme":8,"title":46,"piName":10,"institution":47,"country":48,"year":13,"amount":14,"abstract":49},"cordis-european-research-council-award-790552","Use of PAP as a biomarker and stratifier of pancreatic cancer to improve patient management","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","FR","With an overall 3-year survival rate of only ~6% together with an increased incidence pancreatic ductal adenocarcinoma (PDA), which represents 90% of pancreatic cancer, figures as the solid cancer with the worst prognosis. In trying to understand “the” reason for such negative outlook, one has to consider that the fundamental and clinical research conducted during the last 30 years has focused on characterizing and understanding the properties of the PDA cancer cells, neglecting the specific cel",{"id":51,"funder":7,"programme":8,"title":52,"piName":10,"institution":53,"country":54,"year":13,"amount":55,"abstract":56},"cordis-european-research-council-award-790574","Nanostructure-based label-free biomolecular binding kinetics assay","TECHNISCHE UNIVERSITAET MUENCHEN","DE","€149,873","The aim of this ERC Proof of Concept Grant proposal is the construction, validation, and patenting of a nanoscale device that can accurately measure the binding and unbinding kinetics of target molecules. Accurate measurement of binding and unbinding kinetics of molecules is of great interest to both pharmaceutical companies and academic research groups, and is essential for the development of novel therapeutic compounds. Our proposed nanodevice is based on our knowledge about dynamic nanostruct",{"id":58,"funder":7,"programme":8,"title":59,"piName":10,"institution":60,"country":61,"year":13,"amount":14,"abstract":62},"cordis-european-research-council-award-813103","Flexible Euv SpecTrometer for Attosecond science","CONSIGLIO NAZIONALE DELLE RICERCHE","IT","Attosecond science studies the motion of electrons on atomic and molecular scale, which typically occurs on the timescale of attoseconds (1 as = 10^-18 s). This motion is at the basis of all fundamental processes occurring in Chemistry, Material Science and Biology, and its understanding enables innovation in all these scientific fields. The access to electronic motion on the timescale of attoseconds is based on the analysis of extreme ultra-violet (EUV) harmonic radiation generated when a molec",{"id":64,"funder":7,"programme":8,"title":65,"piName":10,"institution":66,"country":48,"year":13,"amount":10,"abstract":67},"cordis-european-research-council-award-790435","REGENERATING LARGE BONE DEFECTS","INSTITUT POLYTECHNIQUE DE GRENOBLE","In the field of orthopedics and maxillo-facial surgeries, there is still no satisfying solution to repair critical size bone defects. Autograft, which is the current gold standard, presents several drawbacks, including prolonged pain on donor site and higher infection risks. It needs to be replaced by efficient, safe and easy-to-use strategies. Some synthetic bone grafts are providing mechanical and osteoconductive properties, but there is a need to introduce a bioactive molecules, such as a gro",{"id":69,"funder":7,"programme":8,"title":70,"piName":10,"institution":71,"country":25,"year":13,"amount":10,"abstract":72},"cordis-european-research-council-award-812960","User-Friendly Software For the Quantitative Analysis of Textual Data","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","User-Friendly Software For the Quantitative Analysis of Textual Data  My objective is to produce a powerful, flexible, and user-friendly text analytic software tool called Quantext that has a graphical user interface and requires no programming experience. This tool would run entirely as a web application and require only a modern web browser for usage. The backend would run on the open-source quanteda text analysis library written in R and C++ that I developed in ERC-2011-StG-283794-QUANTESS, Q",{"id":74,"funder":7,"programme":8,"title":75,"piName":10,"institution":53,"country":54,"year":13,"amount":14,"abstract":76},"cordis-european-research-council-award-780907","Modular Platform for Controlled Ion Beam Generation","Countless sophisticated macroscopic products rely on innovative materials with unique features, designed with nanoscale precision. To harness the variety of functionalities provided by biomolecules and other complex molecular species as the key ingredient for the design of prospective advanced nanosystems and materials, a current technological gap must be closed: the lack of a universal method capable to handle fragile molecules under vacuum conditions without compromising their integrity. With ",{"id":78,"funder":7,"programme":8,"title":79,"piName":10,"institution":47,"country":48,"year":13,"amount":14,"abstract":80},"cordis-european-research-council-award-790093","Active probing of brain excitability by electrical micro-stimulations for drug discovery","The overall objective of EXCITATOR is to transfer the methods developed in the F-TRACT ERC project (f-tract.eu) around the concept of active probing of brain states with the industrialization goal to make them applicable for fast drug discovery in animal models. The industrialization process will be prepared in collaboration with Synapcell SAS, a biotechnology company that provides the biopharmaceutical industry with innovative drug discovery programs.EXCITATOR has one scientific objective (O), ",{"id":82,"funder":7,"programme":8,"title":83,"piName":10,"institution":84,"country":48,"year":13,"amount":85,"abstract":86},"cordis-european-research-council-award-767064","Vision and Hearing In Action Laboratory","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","€149,866","The objective of VHIALab is the development and commercialization of software packages enabling a robot companion to robustly interact with multiple users. VHIALab builds on the scientific findings of ERC VHIA (February 2014 - January 2019). Solving the problems of audio-visual analysis and interaction opens the door to multi-party and multi-modal human-robot interaction (HRI). In contrast to well investigated single-user spoken dialog systems, these problems  are extremely challenging because o",{"id":88,"funder":7,"programme":8,"title":89,"piName":10,"institution":90,"country":91,"year":13,"amount":10,"abstract":92},"cordis-european-research-council-award-812729","Proof of concept and pre-commercialisation of personalised liquid biopsies in cancer therapy","JYVASKYLAN YLIOPISTO","FI","Extremely high sensitivity is needed for the detection of cancer biomarkers during the follow-up of the treatment or post-operation period.  We have identified a novel technology that enables very sensitive detection of single-nucleotide polymorphism from blood, enabling point-of-care screening of liquid biopsies. Our diagnostics platform will consist of new chemistry and device, and is an open system for designing new diagnostic targets. This will enable customized follow-up of the cancer medic",{"id":94,"funder":7,"programme":8,"title":95,"piName":10,"institution":96,"country":97,"year":13,"amount":14,"abstract":98},"cordis-european-research-council-award-813232","Low cost solar energy conversion to electricity","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","IL","Replacing fossil-fuels with solar energy in electric power generation is one of the most important challenges to humanity. From an economic point of view, the important parameter is the Levelized Cost of Electricity (LCOE), or Levelized Energy Cost (LEC), which is the net present value of the unit-cost of electricity over the lifetime of an energy generating asset. The minimally expected LCOE for any solar energy system in 2030 is 0.045 [€\u002FkWh], similar to today's Photovoltaics (PV) LCOE, and at",{"id":100,"funder":7,"programme":8,"title":101,"piName":10,"institution":102,"country":103,"year":13,"amount":104,"abstract":105},"cordis-european-research-council-award-825359","Augmenting and broadening T-cell responses to glioblastoma - therapeutic vaccine platform based on HCMV expressing NKG2D ligands","SVEUCILISTE U RIJECI, MEDICINSKI FAKULTET","HR","€149,968","The development of an effective vaccine against human cancers is of tremendous importance. Glioblastoma multiforme (GBM) is the most malignant form of brain tumor with extremely poor survival. The human cytomegalovirus (HCMV) is involved in GBM pathogenesis suggesting that viral proteins might provide therapeutic targets. We propose a vaccination strategy against GBM based on a genetically modified HCMV that could target HCMV, as well as tumor specific antigens. The proposal builds on the succes",{"id":107,"funder":7,"programme":8,"title":108,"piName":10,"institution":109,"country":54,"year":13,"amount":110,"abstract":111},"cordis-european-research-council-award-813081","Therapeutic potential of optimized derivatives of an endogenous CXCR4 antagonist for the treatment of cancers and inflammatory diseases","UNIVERSITAET ULM","€149,156","Deregulation of CXCL12 signaling via the CXCR4 chemokine receptor plays a key role in many diseases, including cancer, rheumatoid arthritis, chronic inflammation and cardiovascular disorders. Thus, agents modulating CXCR4 signaling offer many prospects for therapeutic development. CXCR4 is also a major coreceptor for HIV entry. Thus, we used HIV as tool to screen peptide libraries encompassing the entire blood peptidome for novel CXCR4 ligands. This approach allowed the identification of a small",{"id":113,"funder":7,"programme":8,"title":114,"piName":10,"institution":115,"country":116,"year":13,"amount":117,"abstract":118},"cordis-european-research-council-award-812583","Development of a Multispectral, Versatile Film Scanner","UNIVERSITAT ZURICH","CH","€148,320","Film archives contain large and diverse collections of historical films. In order to exhibit and exploit these collectionscommercially, archives need to digitize their holdings. With more than 400 Mio. € per year globally and growth rates of 8 %annually, the digitization of analog film material is an exponentially growing market.However, as a study by the research team has shown, there is no professional high-end film scanner on the market that isable to digitize the whole range of these films.T",{"id":120,"funder":7,"programme":8,"title":121,"piName":10,"institution":122,"country":54,"year":13,"amount":14,"abstract":123},"cordis-european-research-council-award-813086","Penetration-promoting and Imageable Polymeric Micelles as a Platform  Technology for Individualized and Improved Tumor-targeted Drug Delivery","UNIVERSITAETSKLINIKUM AACHEN","PIcelles will assess the commercial viability of a novel theranostic nanoformulation for anticancer therapy. Current nanomedicine platforms are not able to boost response rates and survival times due to two main reasons: (1) the high variability in the accumulation of nanomedicines in tumors and metastases; and (2) the poor tissue penetration of nanomedicines in tumors and metastases. Based on results of the ERC project NeoNaNo, we are developing an imageable and penetration-promoting PIcelles p",{"id":125,"funder":7,"programme":8,"title":126,"piName":10,"institution":127,"country":12,"year":13,"amount":128,"abstract":129},"cordis-european-research-council-award-813132","Development of an effective and safe systemic Myc inhibitor for the treatment of multiple cancer types.","FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO)","€148,875","Current cancer therapies target redundant cellular functions often compensated for by cancer cells, resulting in resistance to treatment. Here we propose an innovative approach to inhibit Myc, a non-redundant and “most-wanted” therapeutic target for human cancer. Targeting Myc has long been considered unfeasible because of the potentially catastrophic side effects in normal tissues. Against this dogma, we showed that Myc inhibition by Omomyc, a Myc mutant designed by Dr. Soucek, has a dramatic t",{"id":131,"funder":7,"programme":8,"title":132,"piName":10,"institution":133,"country":134,"year":13,"amount":135,"abstract":136},"cordis-european-research-council-award-768491","Electromagnetic to Optics Transducer","KOBENHAVNS UNIVERSITET","DK","€149,956","Modern communication and sensing is done with radio- and microwaves on the one hand, and with optical fiber links, on the other. Radio- and microwaves are widely used in commercial and personal communication, as well as in sensing in, for example, medical diagnostics. Optical communication dominates long distance, point-to-point connections, such as internet. This action aims at the development of a miniature device for efficient conversion between these technological platforms.  Within the AdG ",{"id":138,"funder":7,"programme":8,"title":139,"piName":10,"institution":140,"country":12,"year":13,"amount":14,"abstract":141},"cordis-european-research-council-award-812982","Hand-held broadband hybrid graphene-quantum dots spectrometer","FUNDACIO INSTITUT DE CIENCIES FOTONIQUES","Optical Spectrometry is a powerful non-destructive, high throughput technique used extensively for threat and hazardous substance detection, food inspection, process and environmental monitoring and quality control amongst others. The market is fragmented into many niche markets, mainly due to the different wavelengths ranges of interest. Hybrid graphene-quantum dot photodetectors can enable versatile spectrometer covering the whole spectral range from UV to mid-IR. The main goal of SPECTRODOT i",{"id":143,"funder":7,"programme":8,"title":144,"piName":10,"institution":145,"country":25,"year":13,"amount":146,"abstract":147},"cordis-european-research-council-award-790563","Low Cost Real-time Multi-Physics Virtual Reality Training System For In-vitro Fertilisation Microinjection Tasks","UNIVERSITY COLLEGE LONDON","€149,995","The ability to operate on cells is a fundamental capability when developing novel cell based therapies. In this context, the skills needed to manually inspect, prepare and modify cells in-vitro with repeatable micro-nano precision are essential; enabling the creation of new biomedical solutions to fight disease more effectively. Highlighted by the Innovate UK Cell Therapy Catapult, the market opportunity for improved micromanipulation techniques is valued to be >€4.5billion in 2017 and applicabl",{"id":149,"funder":7,"programme":8,"title":150,"piName":10,"institution":151,"country":12,"year":13,"amount":152,"abstract":153},"cordis-european-research-council-award-779611","Computational catalog of multiscale materials: a plugin library for industrial finite element codes","CENTRE INTERNACIONAL DE METODES NUMERICS EN ENGINYERIA","€149,991","The Proof of Concept CATALOG will explore the industrial applicability and potential for commercialization of a prototype of a “computational multiscale material catalog”, to exploit HPROM (high‐performance reduced order modeling), a technology developed in the ERC Advanced Grant COMP-DES-MAT for advanced material simulation. CATALOG will provide extremely fast and accurate multiscale capabilities to existing commercial Finite Element Analysis Solvers (FEAS), greatly enhancing their standard sim",{"id":155,"funder":7,"programme":8,"title":156,"piName":10,"institution":157,"country":54,"year":13,"amount":14,"abstract":158},"cordis-european-research-council-award-813169","Increasing complex I stability as a cure for mitochondrial diseases","KLINIKUM DER UNIVERSITAET ZU KOELN","Mitochondria are found within every human cell and are responsible for the majority of energy production in the cell. When the mitochondria do not function properly, they cause devastating diseases affecting many and often multiple organs with the highest energy needs, such as skeletal muscle, brain, heart and liver. Over the years we have steadily increased our understanding of the genetic and molecular mechanisms leading to mitochondrial disease, developed different models and biomarkers. Unfo",{"id":160,"funder":7,"programme":8,"title":161,"piName":10,"institution":162,"country":163,"year":13,"amount":14,"abstract":164},"cordis-european-research-council-award-812867","Development of antibacterial compounds that block essential transport function","RIJKSUNIVERSITEIT GRONINGEN","NL","Development of new antibiotics is crucial in future since antibiotic resistance is a rapidly growing problem, which severely threatens our ability to combat infectious diseases. Despite the numerous efforts by International Organisations and Governments, Pharmaceutical companies are reluctant to carry out the costly drug development, as the returns are uncertain and evolving drug resistance weakens their business case further. New solutions are thus called for. We have obtained fundamental insig",{"id":166,"funder":7,"programme":8,"title":167,"piName":10,"institution":168,"country":61,"year":13,"amount":169,"abstract":170},"cordis-european-research-council-award-825936","IMPLEMENTATION OF A SUSTAINABLE AND COMPETITIVE SYSTEM TO SIMULTANEOUSLY PRODUCE ASTAXANTHIN AND OMEGA-3 FATTY ACIDS IN MICROALGAE FOR ACQUACULTURE AND HUMAN NUTRITION","UNIVERSITA DEGLI STUDI DI VERONA","€149,955","This project aims at developing an innovative and commercially competitive production platform for high value products as Astaxanthin and Omega-3, to be used for human nutrition or aquaculture. Astaxanthin is a pigment primary produced by microalgae: this carotenoid has a strong antioxidant power and it is used in different fields as healthcare, food\u002Ffeed supplementation and as pigmenting agent in aquaculture. However, cultivation of the main microalgae species producing Astaxanthin is costly du",{"id":172,"funder":7,"programme":8,"title":173,"piName":10,"institution":174,"country":163,"year":13,"amount":175,"abstract":176},"cordis-european-research-council-award-789790","Workforce Sustainability Testing Platform","UNIVERSITEIT UTRECHT","€149,963","With the proposed Workforce Sustainability Testing Platform (Work-STeP) organisations will have a tool to assess their HR practices with regards to workforce sustainability (e.g. engagement, health, performance).The proposed project will have a profound impact on the European business community. By automating all aspects of the platform, Work-STeP is able to offer its services at affordable rates. Where traditional HR analytics are often too costly for small and medium establishments (SMEs), wit",{"id":178,"funder":7,"programme":8,"title":179,"piName":10,"institution":180,"country":181,"year":13,"amount":14,"abstract":182},"cordis-european-research-council-award-779437","Making it happen - Scalable biphasic reactions using a nebulizer-driven continuous flow reactor","PANEPISTIMIO KRITIS","EL","The original ERC grant focused on proving the power that oxygen from the air had in synthesis when its light-excited state was exploited. During the ERC program, we were able to show how simple & readily accessible start materials could be transformed into high value-high interest chemicals through straightforward “one pot” operations. We were also able to show that the diversity of structures accessible using this chemistry is remarkable. Furthermore, it is highly sustainable; representing a ve",{"id":184,"funder":7,"programme":8,"title":185,"piName":10,"institution":186,"country":12,"year":13,"amount":187,"abstract":188},"cordis-european-research-council-award-780440","Mitochondrial membrane-targeted compounds for cancer therapy","UNIVERSIDAD COMPLUTENSE DE MADRID","€149,700","Cancer is one of the leading causes of death in Europe. The economic impact of cancer in Europe has been quantified with a total cost of 126 billion €, including healthcare costs and productivity losses. Although many efforts have been devoted to eradicate cancer, the current treatments are associated with severe side effects and high toxicity. Alternatively, the next generation of cancer treatments targets only malignant cells, which exhibit unique biochemical hallmarks different from their nor",{"id":190,"funder":7,"programme":8,"title":191,"piName":10,"institution":192,"country":97,"year":13,"amount":14,"abstract":193},"cordis-european-research-council-award-811322","Developing proprietary antibacterial phage-based particles against Campylobacter jejuni for food decontamination","TEL AVIV UNIVERSITY","Campylobacter jejuni is the most common foodborne contamination in Europe, affecting millions of people, and costing billions of Euros. Current procedures to treat this contamination do not offer sufficient solutions. Here I present a unique approach to eradicate the pathogen from food by utilizing a cost-effective and safe product that does not alter the taste, texture, or appearance of the food. This innovation involves a spray composed of proprietary phage-based particles, which inject antiba",{"id":195,"funder":7,"programme":8,"title":196,"piName":10,"institution":197,"country":198,"year":13,"amount":14,"abstract":199},"cordis-european-research-council-award-789992","Single-shot dispersion-scan device for the characterization of ultrashort laser pulses","LUNDS UNIVERSITET","SE","The idea to be taken to proof of concept is a novel real-time characterization device for short laser pulses, based upon SIngle-Shot dispersion SCAN (SISCAN). The use of femtosecond laser pulses with duration from the single-cycle to the multi-cycle regime, in various applications in research, industry or medicine demands a precise characterization and control of each laser pulse. We propose a device for measuring the intensity and the phase of laser pulses, based upon dispersion scans, i.e. sca",{"id":201,"funder":7,"programme":8,"title":202,"piName":10,"institution":203,"country":25,"year":13,"amount":204,"abstract":205},"cordis-european-research-council-award-755211","Direct detection of cancer-causing mutations in tumour specimens","THE UNIVERSITY OF BIRMINGHAM","€149,688","Cancers develop because they acquire changes (mutations) in a specific set of genes that promote their growth. Different mutations are associated with cancer aggressiveness, patient prognosis and\u002For the response to treatment. Although these mutations can usually be detected by extracting DNA from tumour specimens, this provides incomplete information because it is common for mutations not to occur in every cell that makes up the cancer. In a number of research and clinical settings, it is of gre",{"id":207,"funder":7,"programme":8,"title":208,"piName":10,"institution":209,"country":91,"year":13,"amount":210,"abstract":211},"cordis-european-research-council-award-789868","Low cost coherent light sources from nanoparticle array surface plasmon polariton systems","AALTO KORKEAKOULUSAATIO SR","€149,895","Low cost coherent light sources from nanoparticle array surface plasmon polariton systemsLasers are ubiquitous sources of coherent light used in technology and everyday life, from optical communications enabling the internet to the lasers used in manufacturing, medical care and information storage. Coherent light sources with a small footprint, that are ultrafast and low cost, have low energy consumption could be used in sensor, switch and biomedical applications. Based on recent results of the ",{"id":213,"funder":7,"programme":8,"title":214,"piName":10,"institution":215,"country":12,"year":13,"amount":216,"abstract":217},"cordis-european-research-council-award-825763","Innovative therapeutic tools to ameliorate chemotherapy-induced cardiotoxicity","FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)","€149,937","p38_InTh aims at improving the potency of a new class of highly specific p38 pathway inhibitors and validate their potential therapeutic use to ameliorate chemotherapy-induced cardiotoxicity without affecting the cancer cell toxicity of the chemotherapeutic. Chemotherapeutics used for cancer treatments have serious side effects, both the most broad-spectrum ones (such as anthracyclines) and the directed ones (such as trastuzumab). In particular, the cardiotoxicity is a major issue associated to ",{"id":219,"funder":7,"programme":8,"title":220,"piName":10,"institution":221,"country":25,"year":13,"amount":222,"abstract":223},"cordis-european-research-council-award-812904","A customised low-cost ultralight aircraft for survey, filming and animal tracking in wild environments.","THE ROYAL VETERINARY COLLEGE","€149,526","This proposal draws on the extensive technical developments of Ad-G 323041 LOCATE to commercialise the know-how to build a low-cost aircraft with integrated aerial survey, filming and tracking technology capable of operating in low-infrastructure environments. These requirements are common to many applications and there is currently no affordable off-the-shelf solution. Our product is unique, providing a technologically-advanced integrated data collection system controlled by a single pilot. Mod",{"id":225,"funder":7,"programme":8,"title":226,"piName":10,"institution":227,"country":12,"year":13,"amount":14,"abstract":228},"cordis-european-research-council-award-790027","Autonomously Healable Thermoplastic Polymer Coatings based on Cooperative Interactions","UNIVERSIDAD AUTONOMA DE MADRID","Modern society demands for materials that are reliable, for safety reasons, durable, to offer prolonged service lifetimes, and cost- and energy-efficient, to preserve natural resources and produce minimum waste and environmental impact. In this context, self-healing polymers are “smart” materials with the ability to repair themselves autonomously or to heal on-demand upon exposure to an external stimulus. However, the broad commercialization and universal use of self-healing thermoplastic polyme",{"id":230,"funder":7,"programme":8,"title":231,"piName":10,"institution":232,"country":163,"year":13,"amount":14,"abstract":233},"cordis-european-research-council-award-790395","Beam-steered Reconfigurable Optical-Wireless System for Energy-efficient communication – Proving the Concept","TECHNISCHE UNIVERSITEIT EINDHOVEN","Worldwide, wireless communication traffic is growing at a staggering pace. Driven by digitalization of nearly every aspect of our lives and by the ‘Fourth Industrial Revolution’, the numbers of mobile broadband devices as well as the proliferation of small sensing and actuating devices (the ‘Internet of Things’) are exploding. The vast majority of wireless traffic is generated indoors, and radio-based wireless networks such as Wi-Fi are getting into severe states of traffic congestion.By means o",{"id":235,"funder":7,"programme":8,"title":236,"piName":10,"institution":237,"country":163,"year":13,"amount":238,"abstract":239},"cordis-european-research-council-award-768657","Stimulating mir-106b expression to regenerate the myocardium","UNIVERSITEIT MAASTRICHT","€149,875","Most people who develop ischemic HF have (or had) an ischemic heart condition first (e.g. myocardial infarction, MI). Restoring damaged heart muscle tissue therefore represents a fundamental mechanistic strategy to treat HF. Cardiac regeneration after ischemic damage can be achieved by stimulating the proliferation of already existing (endogenous) cardiomyocytes rather than having to rely on the implantation of exogenous cells (i.e. stem cell therapy). Compelling evidence supports that expanding",{"id":241,"funder":7,"programme":8,"title":242,"piName":10,"institution":243,"country":25,"year":13,"amount":244,"abstract":245},"cordis-european-research-council-award-812938","3DTransducers: Functional 3D Printed Transducer and Sensor Systems","UNIVERSITY OF STRATHCLYDE","€146,334","Sensors are ubiquitous in the modern technological world. From the numerous sensors everyone carries within their smartphone, through the pervasive nature of sensors within human machines, to the oncoming explosion of the “Internet of Things” promising immense interconnected networks of sensor enabled systems in virtually every aspect of human life. Micro-electro-mechanical systems (MEMS) as silicon integrated circuits (ICs) are the base technology for nearly all such sensors. In 2017 the worldw",{"id":247,"funder":7,"programme":8,"title":248,"piName":10,"institution":249,"country":54,"year":13,"amount":14,"abstract":250},"cordis-european-research-council-award-780487","Versatile and Innovative Detector for Electron Optics","FORSCHUNGSZENTRUM JULICH GMBH","The VIDEO project will professionalize and integrate software and develop open standard file formats for electron microscopy based on results from the ERC Advanced Grant project IMAGINE, supplemented with results and support from other research groups and hardware vendors. Our goal is to combine these separate activities into an open software platform and to develop open standards, which will enable vendors and users to develop interoperable solutions in this area, and to explore business and su",{"id":252,"funder":7,"programme":8,"title":253,"piName":10,"institution":254,"country":25,"year":13,"amount":14,"abstract":255},"cordis-european-research-council-award-790445","HEI10-mediated elevations in bread wheat recombination","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","The increasing demand for food, in the context of a changing climate and deteriorating environments, will be one of the major challenges facing society in the coming decades. However, as breeding a new crop variety currently takes on average 10 years, the predicted changes in food demand and climate are only several breeding cycles away. Meiotic recombination and crossover is a major tool used in crop breeding when diverse strains are hybridized in order to combine useful traits. Therefore, in t",{"id":257,"funder":7,"programme":8,"title":258,"piName":10,"institution":259,"country":61,"year":13,"amount":14,"abstract":260},"cordis-european-research-council-award-779802","Immuno-targeting of human AML quiescent cells by a novel phage display approach.","ISTITUTO EUROPEO DI ONCOLOGIA SRL","One main objective of our ERC Advanced Grant project (InMec, No 341131) was to determine how cancer stem cells (CSCs) contribute to tumour growth, and the relative impact of quiescent versus proliferative CSCs. In Acute Myeloid Leukaemia (AML), our results strongly suggest that quiescent leukaemia stem cells are critical for leukaemia maintenance and relapse after treatments. AML is an aggressive and frequently fatal hematologic malignancy. It is usually sensitive to chemotherapy at its onset, l",{"id":262,"funder":7,"programme":8,"title":263,"piName":10,"institution":264,"country":265,"year":13,"amount":14,"abstract":266},"cordis-european-research-council-award-789999","Automated Improvement of Continuous User interfaces","VRIJE UNIVERSITEIT BRUSSEL","BE","We propose to develop two tools for creating, in a systematic way, better user interfaces based on continuous, non-symbolic actions, such as swipes on a touch screen, 3-D motions with a hand-held device, or breath patterns in a user interface for otherwise paralyzed patients. The tools are based on two experimental\u002Fcomputational techniques developed in the ABACUS project: iterated learning and social coordination.In iterated learning, sets of signals produced by one user are learned and reproduc",{"id":268,"funder":7,"programme":8,"title":269,"piName":10,"institution":270,"country":265,"year":13,"amount":271,"abstract":272},"cordis-european-research-council-award-789598","Adaptive transmission electron microscopy: development of a programmable phase plate","UNIVERSITEIT ANTWERPEN","€148,500","Adaptive optics, the technology to dynamically program the phase of optical waves has sparked an avalanche of scientific discoveries and innovations in light optics applications. Nowadays, the phase of optical waves can be dynamically programmed providing research on exotic optical beams and unprecedented control over the performance of optical instruments. Although electron waves carry many similarities in comparison to their optical counterparts, a generic programmable phase plate for electron",{"id":274,"funder":7,"programme":8,"title":275,"piName":10,"institution":276,"country":97,"year":13,"amount":277,"abstract":278},"cordis-european-research-council-award-813109","Development of Circadian Rhythms on Chip","THE HEBREW UNIVERSITY OF JERUSALEM","€149,969","The liver is responsible for the systemic regulation of human metabolism, responding to a dynamically changing hormonal and nutritional environment. These physiological dynamics limited our ability to model human metabolism in our efforts to create efficient pharmaceutical interventions for prevalent metabolic diseases, such as fatty liver disease, obesity, and type-2 diabetes. In addition, physiological dynamics impact the pharmacokinetics and toxicity of drugs due to circadian changes in drug ",{"id":280,"funder":7,"programme":8,"title":281,"piName":10,"institution":140,"country":12,"year":13,"amount":14,"abstract":282},"cordis-european-research-council-award-786285","Hybrid quantum dot and graphene wearable sensor for eye tracking","The main goal of GTRACK is to demonstrate a semi-transparent eye-tracking system that is disposed in the line of sight of the user, for portable applications. To this end, we will use hybrid Quantum Dot – Graphene photodetectors. Eye-tracking existed since the 1800’s, but is expected to appear abundantly in our daily lives with the advent of virtual and augmented reality. In the existing systems, the camera has to be placed sufficiently close to the eye to capture enough IR light at sufficiently",{"id":284,"funder":7,"programme":8,"title":285,"piName":10,"institution":286,"country":287,"year":13,"amount":14,"abstract":288},"cordis-european-research-council-award-789760","Novel 3D platforms to engineer bone microtissues for in vitro disease models","UNIVERSIDADE DE AVEIRO","PT","Osteosarcoma is a rare but devastating bone tumour that mainly affects children, adolescents and elderly. This type of tumour is very resistant to therapy, being thus urgent to find new effective treatments. In vitro tumour models can recapitulate many aspects of the natural tumour environment, and could be used to improve the predictive value of the effect of anticancer drug candidates. The aim of MicroBone is the development of biological relevant spherical-based 3D disease models that could b",{"id":290,"funder":7,"programme":8,"title":291,"piName":10,"institution":133,"country":134,"year":13,"amount":14,"abstract":292},"cordis-european-research-council-award-825797","Ultracoherent force sensors","As part of our ERC-funded quest for quantum-enabled micro- and nanomechanical resonators, we have developed a novel type of ‘soft-clamped’ mechanical sensors. They combine phononic engineering via periodic patterning with high tensile stress. With unprecedented quality factors and low force noise, they provide a powerful platform for an array of force sensing techniques. Applications are expected not only in quantum technologies, but also materials science and nano-medicine, by improving nano-sc",{"id":294,"funder":7,"programme":8,"title":295,"piName":10,"institution":296,"country":297,"year":13,"amount":10,"abstract":298},"cordis-european-research-council-award-825586","A Novel Detection protocols for REliable prostate cancer Assays","CHEMICKY USTAV SLOVENSKEJ AKADEMIEVIED","SK","The technology validation was successfully completed indicating a great commercial potential, and the innovative and inventive aspects of the assay platform are now covered by the filed priority European Patent Office (EPO) patent applications. Validated glycoprofiling of the proteins now uses lectins in a format, fully compatible with clinical PSA assay kits. This PoC grant focuses on 1. Pre-clinical retrospective validation of the early stage biomarker of prostate cancer (PCa) and 2. Commercia",{"id":300,"funder":7,"programme":8,"title":301,"piName":10,"institution":237,"country":163,"year":13,"amount":302,"abstract":303},"cordis-european-research-council-award-779860","Reading the mind’s eye at 7 Tesla  - A fMRI-based communication brain-computer interface for severely motor-impaired patients","€148,530","The Advanced ERC project ColumnarCodeCracking has pioneered ultra-high field fMRI at 7 Tesla for sub-millimeter neuroscience applications targeting cortical columns and cortical layers. One sub-project of the ERC project was to explore whether it is possible to build new brain computer interfaces (BCIs) exploiting the strong signal quality and higher resolution achievable at ultra-high magnetic fields. As part of our research (Emmerling et al., 2017, http:\u002F\u002Fcordis.europa.eu\u002Fnews\u002Frcn\u002F124885_en.ht",{"id":305,"funder":7,"programme":8,"title":306,"piName":10,"institution":307,"country":97,"year":13,"amount":308,"abstract":309},"cordis-european-research-council-award-825076","Translation and Commercialization of a QSOX1-inhibitory Antibody Targeting the Tumor Microenvironment in Breast Cancer","WEIZMANN INSTITUTE OF SCIENCE","€149,998","The high number of cancer cases worldwide points to the large global demand for therapeutics for adenocarcinomas (the majority of lung, breast, and pancreatic cancers). Cancer metastases cause more than 90% of cancer patient deaths. There is thus great need to develop more targeted cancer therapies, as well as therapies that enhance the delivery and penetration of chemotherapies to reduce side effects and increase efficacy. A specific societal need is improved therapies for triple-negative breas",{"id":311,"funder":7,"programme":8,"title":312,"piName":10,"institution":307,"country":97,"year":13,"amount":14,"abstract":313},"cordis-european-research-council-award-765111","Antibody mediated clearance of senescent cells for treatment of COPD","Chronic Obstructive Pulmonary Disease (COPD) is a group of chronic diseases characterized by airflow limitations in the lung.  COPD is a critical international health problem. It is estimated to affect up to 600 million people worldwide and by 2020 it will become the third most frequent cause of death.  In Europe alone, COPD affects up to 10% of people (i.e. more people than breast cancer and diabetes) and it takes the life of around 300,000 Europeans each year. Up to date, COPD has no cure as c",{"id":315,"funder":7,"programme":8,"title":316,"piName":10,"institution":317,"country":91,"year":13,"amount":14,"abstract":318},"cordis-european-research-council-award-790274","The inhibition of sorting proteins as a therapeutic avenue in HER2 positive breast cancer","TURUN YLIOPISTO","HER2+ breast cancers are an aggressive type of breast cancer and have a poor prognosis. There are many therapies currently on the market to target this type of cancer, however they fail to deliver effective clinical results due to therapy resistance. In our ERC-CoG project, we found that proper endosomal trafficking is required for functional HER2 oncogenic signalling at the plasma membrane. Targeting HER2 endosomal traffic can result in effective treatment of HER2+ cancers, without the risk of ",{"id":320,"funder":7,"programme":8,"title":321,"piName":10,"institution":322,"country":48,"year":13,"amount":323,"abstract":324},"cordis-european-research-council-award-780458","MAmmary chemoresistant Tumor deAth by Directed cell ORientation","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","€149,645","Breast cancer is the most common cancer in women worldwide, with nearly 1.7 million new cases diagnosed in 2012. Fortunately, the availability of diagnosis tools to detect mammary neoplastic tissues, as well as transcriptomic biomarkers helping for prognosis, and the diversity of treatment options for primary tumors allows a 90% 5-year survival rate. However the metastatic grade of breast cancer is still not curable.Advances from basic research in the last decade outline the epithelial-to-mesenc",{"id":326,"funder":7,"programme":8,"title":327,"piName":10,"institution":328,"country":163,"year":13,"amount":14,"abstract":329},"cordis-european-research-council-award-767235","An EEG calibration toolkit for monitoring rehabilitation of stroke patients.","TECHNISCHE UNIVERSITEIT DELFT","An EEG calibration toolkit for monitoring rehabilitation of stroke patientsEEG records electric potential differences from electrodes attached to the human skin. Since it is a brain imaging technique that provides a direct measure of neural activity, it is an ideal device to monitor stroke rehabilitation. For instance, the amplitude of an EEG response to a fixed external stimulus on the wrist could act as a biomarker quantifying the number of active cells in the primary somatosensory cortex. In ",{"id":331,"funder":7,"programme":8,"title":332,"piName":10,"institution":333,"country":334,"year":13,"amount":32,"abstract":335},"cordis-european-research-council-award-779909","Articular cartilage regeneration through the recruitment of bone marrow derived mesenchymal stem cells into extracelluar matrix derived scaffolds anchored by 3D printed polymeric supports","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","IE","Osteoarthritis (OA), the most common form of arthritis, is a serious disease of the joints affecting nearly 10% of the population worldwide. The onset of OA has been associated with defects to articular cartilage that lines the bones of synovial joints. Current strategies to treat articular cartilage defects are ineffective and\u002For prohibitively expensive. The aim of ANCHOR is to develop and commercialise a new medicinal product for articular cartilage regeneration that recruits endogenous bone m",{"id":337,"funder":7,"programme":8,"title":338,"piName":10,"institution":339,"country":48,"year":13,"amount":340,"abstract":341},"cordis-european-research-council-award-825829","VIrTual BrAin PErfusion: Assessing cerebrovascular function by High Performance Computing from 3D brain vessel network data for vascular-targeted drug development in neurodegenerative diseases.","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€149,738","With the recent discovery that brain blood flow decreases — in a statistical and epidemiologic sense — before accumulation of neurotoxic deposits (e.g. amyloid and tau) and before any measurable cognitive deficits, the brain vascular system is increasingly recognized as a key player in the development of Alzheimer’s Disease (AD). This opens the way for the development of new disease-modifying therapeutic strategies targeting vascular pathways at early stages of AD, i.e. long before the neurodege",{"id":343,"funder":7,"programme":8,"title":344,"piName":10,"institution":339,"country":48,"year":13,"amount":14,"abstract":345},"cordis-european-research-council-award-780058","OCEAN SENTINEL","Fisheries are operating worldwide over nation’s Economic Exclusive Zones (EEZ) as well as over international waters. Information on the location of fishing is rarely known, especially in international waters, yet it is critical since in many oceanic sectors non declared and illegal fisheries are affecting negatively ecosystems through over exploitation and by catch of non-target species Knowledge about the distribution of fishing boats is fundamental for the regulation of fishing activities as w",{"id":347,"funder":7,"programme":8,"title":348,"piName":10,"institution":339,"country":48,"year":13,"amount":349,"abstract":350},"cordis-european-research-council-award-789463","Photon High Way - Integrated single-photon sources: crossing the chasm","€147,463","Optical quantum technologies—the use of the quantum properties of light to benefit from quantum-enhanced performances in communications, computation, simulation and sensing—require highly efficient single photon sources. Such devices are  difficult to fabricate and today’s sources present an efficiency intrinsically limited to few percents. Within the framework of the ERC StG QD-CQED, the PI team developed a new generation of single photon sources based on semiconductor quantum dots in cavities ",{"id":352,"funder":7,"programme":8,"title":353,"piName":10,"institution":31,"country":25,"year":13,"amount":354,"abstract":355},"cordis-european-research-council-award-780360","A microfluidic chip for non-invasive, early detection of pancreatic cancer – liquid biopsy","€149,996","Pancreatic cancer is the fourth-leading cause of cancer related mortality and is predicted to be the second leading cause of cancer death by 2030. Widely regarded as a death sentence, the 5-year survival rate is only 3% in the UK and this figure has not changed over the past four decades due to lack of specific therapies and inability to detect it early. Several years often elapses from the beginning of the disease to the patient’s diagnosis, suggesting a window of opportunity for early detectio",{"id":357,"funder":7,"programme":8,"title":358,"piName":10,"institution":31,"country":25,"year":13,"amount":135,"abstract":359},"cordis-european-research-council-award-825796","Ultrasensitive Quantification of Proteins based on Amplification of DNA Displaced from DNA Aptamer Duplex using Semiconductor Technology","The life expectancy in both EU and US fell in 2015. A third of premature deaths could be preventable and large part is due to obesity – a major risk factor for many chronic diseases including diabetes. Worldwide about 40% of adults are overweight and 13% obese. Regulation of food metabolism is becoming one of the main issues relevant to human health today. Obesity is preventable, however there are no currently available non-invasive and cost-effective obesity treatments, pointing to the need of ",{"id":361,"funder":7,"programme":8,"title":362,"piName":10,"institution":96,"country":97,"year":13,"amount":14,"abstract":363},"cordis-european-research-council-award-813228","Liquid Foam Therapy (LIFT) for Acute Respiratory Distress Syndrome (ARDS)","Acute Respiratory Distress Syndrome (ARDS) is an inflammatory lung condition caused e.g. by sepsis, pneumonia and head or chest injury, affecting annually 133,000 people in Europe and 255,000 in the US. ARDS is characterized by the depletion of the lungs’ inner liquid coating (pulmonary surfactant), which reduces surface tension forces and allows the lungs to expand. Patients span across all age groups and lay anesthetized in the intensive care unit with mortality rates at 40%. Although surfacta",{"id":365,"funder":7,"programme":8,"title":366,"piName":10,"institution":367,"country":12,"year":13,"amount":14,"abstract":368},"cordis-european-research-council-award-780255","Separation membranes for carbon dioxide removal from gas streams","FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA","Carbon dioxide separation, capture and utilization is expected to become a major business opportunity in the near future. Beyond current industrial needs for natural gas or biogas purification, regulatory issues imposing emission control will also contribute to a fast growth in this market. At the industrial level, CO2 separation is still an expensive process, typically based in alkaline amine solutions or cryogenic distillation, and low-cost alternatives are needed. Membrane-based technologies ",{"id":370,"funder":7,"programme":8,"title":371,"piName":10,"institution":372,"country":54,"year":13,"amount":10,"abstract":373},"cordis-european-research-council-award-790155","In-Field Live Sensing of Nitrate in Crops for Real-Time Fertilization Adjustment","RUHR-UNIVERSITAET BOCHUM","Today it is common practice for farmers to provide crops with more fertilizers than the plants need. However, this practice has negative economic and environmental impacts. While accurate and timely knowledge of Nitrogen availability could enable adjustment of the inputs, the existing analytical tools for Nitrogen quantification are insufficiently used because of various limitations related to costs, laborious procedures or sensitivity to environmental factors. Our nitrate biosensor recently dev",{"id":375,"funder":7,"programme":8,"title":376,"piName":10,"institution":377,"country":265,"year":13,"amount":378,"abstract":379},"cordis-european-research-council-award-780718","Miniature on-chip Raman spectrometer for personal volatile organic compound (VOC) monitoring","UNIVERSITEIT GENT","€149,609","We aspire to build the smallest and most lightweight Raman spectrometer in the world, with a target size of 5x10x1 mm3 and a weight of only 0.1 g. The innovation builds on the combination of three key results of the ERC Advanced Grant project InSpectra (2011-2017): 1. Demonstration of Nanophotonic waveguide Enhanced Raman Spectroscopy (NERS); 2. Demonstration of a novel on-chip Fourier Transform Spectrometer (FTS); 3. Demonstration of the integration of III-V light sources on a silicon platform ",{"id":381,"funder":7,"programme":8,"title":382,"piName":10,"institution":383,"country":265,"year":13,"amount":384,"abstract":385},"cordis-european-research-council-award-727730","Microfluidic bubble JET flow CELL sorter for cell therapy","INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM","€149,379","'T cell based cancer therapy has been recognized as one of the most promising future cancer therapy methods. In a typical T cell therapy course, relevant T cells are isolated from the patient’s blood, modified against certain cancer markers, and infused back into the patient’s body where the engineered T cells direct the immune system to attack and finally eliminate the malignant tumor cells and tissues. Recent clinical research demonstrated that purified T cell subsets could greatly improve the",{"id":387,"funder":7,"programme":8,"title":388,"piName":10,"institution":389,"country":390,"year":13,"amount":14,"abstract":391},"cordis-european-research-council-award-789817","Affordable photonic-chip based optical nanoscopy","UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET","NO","The invention of super-resolution optical microscopy, commonly referred to as optical nanoscopy, has provided a glimpse of future impacts on cell-biology and health. Imagine the possibilities of scientific discoveries if every research and clinical lab is equipped with an optical nanoscope that is capable of imaging with resolution of sub-50 nm. Even though nanoscopy offers unprecedented opportunities, the widespread adoption of present nanoscopy is limited due to its present limitations, mainly",{"id":393,"funder":7,"programme":8,"title":394,"piName":10,"institution":395,"country":12,"year":13,"amount":14,"abstract":396},"cordis-european-research-council-award-789875","Innovative Polymeric Batteries by 3D Printing","UNIVERSIDAD DEL PAIS VASCO\u002F EUSKAL HERRIKO UNIBERTSITATEA","One of the actual limitations of the current batteries is their rigidity and limited shape availability (cylindrical or flat). Furthermore, the manufacturing of current electrodes\u002Fcells is a long process which requires big investments  for battery fabrication facilities. The idea of “iPES-3DBat” Proof of Concept grant will be to develop polymer batteries by  a fast and cheap 3D printing process. Compared to the traditional planar structure of cells, 3D structuring provides different shapes as we",{"id":398,"funder":7,"programme":8,"title":399,"piName":10,"institution":209,"country":91,"year":13,"amount":400,"abstract":401},"cordis-european-research-council-award-812841","Low-power spin-wave-based computing","€149,830","Downscaling of Si-based microprocessors has considerably increased the amount of heating in computers and other information and communication technology (ICT) devices. As a result, computer servers in big data centres waste more than 90% of the electricity they pull off the grid. High-density electrical currents in microprocessors and interconnects cause excessive warm-up via an effect known as Joule heating. To fulfil future requirements for data transmission and processing rates with low energ",{"id":403,"funder":7,"programme":8,"title":404,"piName":10,"institution":405,"country":163,"year":13,"amount":406,"abstract":407},"cordis-european-research-council-award-825974","ALgorithms EXposed. Investigating Automated Personalization and Filtering for Research and Activism","UNIVERSITEIT VAN AMSTERDAM","€149,922","Personalization algorithms—filtering content on the basis of someone's profile—increasingly mediate the web experience of users. By forging a specific reality for each individual, they silently shape customized 'information diets': in other words, they determine which news, opinions and rumors users are exposed to. Restricting users’ possibilities, they ultimately infringe on their agency. As exposed by the recent Cambridge Analytica scandal, they are supported by questionable data sharing pract",{"id":409,"funder":7,"programme":8,"title":410,"piName":10,"institution":411,"country":390,"year":13,"amount":10,"abstract":412},"cordis-european-research-council-award-812986","Commercial feasibility of a kit for the identification of epigenetic markers in farmed fish","NORD UNIVERSITET","Domestication and selective breeding of the major commercial fish species are essential to enable sustainability of the rapidly expanding aquaculture sector. The existing improvement programmes are based exclusively on genetic markers, overlooking the fact that selection for complex traits is strongly affected by environmental conditions and that epigenetics likely account for a large proportion of the observed phenotypic variation. Non-coding RNAs (e.g., miRNAs) and cytosine methylation (5mC) a",{"id":414,"funder":7,"programme":8,"title":415,"piName":10,"institution":416,"country":54,"year":13,"amount":14,"abstract":417},"cordis-european-research-council-award-790139","A versatile ultrafast Click platform for antibody based radio diagnostics","JOHANNES GUTENBERG-UNIVERSITAT MAINZ","Diagnosing cancer as early as possible is one of the most powerful strategies in modern medicine to improvehuman well-being. Antibodies (Abs) are excellent molecules that can be used to target specific tumors. As Absrequire hours to days for accumulating on tumor surfaces, the use of Abs for nuclear imaging (such as PETimaging) is limited by the short half-lives of popular radioisotopes. Therefore, we plan to move the step of radiolabelingfrom the bench to the tumor itself. However, the entangle",{"id":419,"funder":7,"programme":8,"title":420,"piName":10,"institution":421,"country":54,"year":13,"amount":14,"abstract":422},"cordis-european-research-council-award-813127","Unbreakable HEART: a reconfigurable and self-healing isolated dc\u002Fdc converter (U-HEART)","CHRISTIAN-ALBRECHTS-UNIVERSITAET  ZU KIEL","Isolated dc\u002Fdc converters are increasingly employed as key components in data center, aerospace and electrical distribution, because of their capability to guarantee controllability and improve system efficiency despite power electronics is still more prone to failure with respect to other components of such systems. Fault-tolerant operation, when needed, is typically achieved through redundancy, which entails higher costs. The goal of U-HEART is to obtain fault-tolerant operation of the isolate",{"id":424,"funder":7,"programme":8,"title":425,"piName":10,"institution":426,"country":54,"year":13,"amount":427,"abstract":428},"cordis-european-research-council-award-790594","High-performance, affordable super-resolution platform for the life sciences","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€149,187","Since their invention, super-resolution microscopy approaches are starting to transform research in the life sciences by enabling spatial resolution below the classical diffraction limit of light. In order to establish super-resolution microscopy as a standard research tool in the life sciences, researchers need to be able to readily access the three main technological pillars of super-resolution microscopy: instrumentation, software, and labeling probes. To date, the instrumentation is typicall",{"id":430,"funder":7,"programme":8,"title":431,"piName":10,"institution":432,"country":54,"year":13,"amount":14,"abstract":433},"cordis-european-research-council-award-789948","Illuminating every sound with lasers, coding words and complex sounds with light.","UNIVERSITAT DES SAARLANDES","An estimated 360 million people worldwide are living with disabling hearing impairment. This number is rising mainly due to a growing global population and longer life expectancies and increasing noise exposure. Unaddressed hearing loss poses an annual global cost of 750 billion international dollars. Interventions to prevent, identify and compensate or cure hearing loss are cost-effective and can bring great benefit to individuals. Currently available auditory prostheses based on mechanical or ",{"id":435,"funder":7,"programme":8,"title":436,"piName":10,"institution":437,"country":198,"year":13,"amount":14,"abstract":438},"cordis-european-research-council-award-811187","Securing Web Applications by Information Flow Tracking","CHALMERS TEKNISKA HOGSKOLA AB","In today’s technology-centric world, web applications are a keyenabler for many day-to-day activities ranging from online banking toin-vehicle infotainment. These applications have access to a wealth ofsensitive information. Unauthorized disclosure and corruption of thisinformation may result in financial damage, privacy violations, andloss of human lives.At the heart of modern web applications lies the *JavaScript*language. When a user visits a web page, JavaScript code fromdifferent sources is",{"id":440,"funder":7,"programme":8,"title":441,"piName":10,"institution":442,"country":163,"year":13,"amount":14,"abstract":443},"cordis-european-research-council-award-789283","A reliable CXCL4 biomarker assay to improve diagnosis and treatment of Systemic Sclerosis","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","Systemic Sclerosis (SSc, scleroderma) is a complex autoimmune disorder of unclear aetiology, culminating in excessive extracellular matrix deposition (fibrosis\u002Ftissue scarring) in skin and internal organs (e.g. joints, heart, lung, gastrointestinal tract and kidneys). More than half of the patients will ultimately die as a result of organ complications. The medical need is exacerbated by the lack of curative treatments and the lack of specific and sensitive molecular markers to facilitate reliab",{"id":445,"funder":7,"programme":8,"title":446,"piName":10,"institution":237,"country":163,"year":13,"amount":10,"abstract":447},"cordis-european-research-council-award-737586","Proof of principle for a first in class neuroprotective therapy in stroke and other acute neurodegenerative conditions","Stroke represents currently one of the largest – if not the largest - unmet medical need: It is the second leading cause of death and the leading cause of disability. In contrast to this high demand for effective treatments, there is only one drug available, a blood-clot dissolving agent. However, this drug is marginally effective has over 30 contra-indications, and bears an extremely high risk of causing fatal bleeding that 85% of all stroke patients are not treated with it. The needed innovati",{"id":449,"funder":7,"programme":8,"title":450,"piName":10,"institution":232,"country":163,"year":13,"amount":14,"abstract":451},"cordis-european-research-council-award-780160","New chemical building blocks for de-icing and anti-icing of car windows","Ice accretion of car windshields is a road safety concern in fall and wintertime as frost impairs the vision of drivers that do not sufficiently de-ice their car windshields, which may cause serious road accidents. Windshield washer fluids are crucially important for rapid car windshield de-icing which is most efficient through a combination of thermal, mechanical, and chemical action; i.e., local heating, scraping, and the application of appropriate windshield washer fluids. At present, windshi",{"id":453,"funder":7,"programme":8,"title":454,"piName":10,"institution":254,"country":25,"year":13,"amount":455,"abstract":456},"cordis-european-research-council-award-825803","Protein Capsules","€149,997","In the ProtCap project, we will translate basic technology, developed in the context of the ERC project PhysProt, towardscommercial applications. The technological focus will be on microscapsules assembled through microfluidic techniquesfrom natural proteins. Encapsulation increasingly underlies the storage and formulation of active components and is agrowing market which impacts areas from cosmetics to personal health-care. In this context, synthetic polymers are thestandard material for formin",{"id":458,"funder":7,"programme":8,"title":459,"piName":10,"institution":460,"country":61,"year":13,"amount":14,"abstract":461},"cordis-european-research-council-award-780417","Engineered bacterial Outer Membrane Vesicles (OMVs) for colorectal cancer immunotherapy","UNIVERSITA DEGLI STUDI DI TRENTO","This proposal originates from recent results obtained in the course of the Advanced ERC Project “OMVac”, the scope of which is to exploit the unique adjuvanticity properties of bacterial Outer Membrane Vesicles (OMVs) for developing innovative vaccines against infectious diseases and cancer. In particular, Synthetic Biology was applied to engineer OMVs with FAT1, a tumour associated antigen expressed in most primary and metastatic colorectal cancers (CRC). Using cancer models in immunocompetent ",{"id":463,"funder":7,"programme":8,"title":464,"piName":10,"institution":465,"country":48,"year":13,"amount":14,"abstract":466},"cordis-european-research-council-award-825713","Development of new therapy for rare motor neuron diseases","INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE","Hereditary spastic paraplegias are a group of rare neurodegenerative diseases due to the degeneration of the long axons of cortical motor neurons. Some complex forms of the disease are also characterized by cognitive impairment. Currently, the only available treatments are symptomatic, act on the motor symptoms and do not prevent or delay the disease progression. There is therefore a strong demand of clinicians as well as of patients and their families for the development of any treatment that c",{"id":468,"funder":7,"programme":8,"title":469,"piName":10,"institution":254,"country":25,"year":13,"amount":470,"abstract":471},"cordis-european-research-council-award-779444","Device for much improved performance portable power","€142,324","\"Portable power (~1-20 W) for small electronic devices is a high value added market. Batteries are the most convenient power devices but have relatively low energy capacity per unit mass and also slow recharge times. Micro-solid oxide fuel (micro-SOFC) cells are much better on both counts but currently operate at too high of a temperature (>500°C). This project will reduce that temperature by 200°C in prototype test devices. It will do this by exploiting much improved materials in the micro-SOFC",{"id":473,"funder":7,"programme":8,"title":474,"piName":10,"institution":475,"country":61,"year":13,"amount":14,"abstract":476},"cordis-european-research-council-award-789815","A Minimalist Peptide Elastomer","POLITECNICO DI MILANO","The MINIRES project aims at developing and bringing to the market a revolutionary bioelastomer material based on a novel strategy of structural modification of a “minimalist” peptide sequence derived from Resilin (Res), i.e., a polymeric rubber-like natural protein with outstanding elasticity, critical in the flight and jumping systems of insects. In the course of the ERC funded Starting Grant FOLDHALO (grant agreement no. 307108), I focused on the modification of a repeat sequence of the Exon-1",{"id":478,"funder":7,"programme":8,"title":479,"piName":10,"institution":237,"country":163,"year":13,"amount":14,"abstract":480},"cordis-european-research-council-award-813200","Commercial feasibility of non-pathogenic Clostridium-Mediated Cancer Immunotherapy:  leveraging the presence of tumour hypoxia & necrosis","Immunotherapeutic strategies are powerful weapons in combating malignancies. However, only a minority of patients benefit from this therapeutic modality, as tumours develop mechanisms of immune escape and suppression and uptake of (antibody-based) agents in tumors is limited. The urgency of investigating novel strategic approaches is dictated by the high incidence and mortality rates of cancer worldwide. Lung cancer, in particular, is the leading cancer with respect to incidence and mortality (1",{"id":482,"funder":7,"programme":8,"title":483,"piName":10,"institution":133,"country":134,"year":13,"amount":14,"abstract":484},"cordis-european-research-council-award-790206","Filter Integrated single-Photon Sources","The FIPS proof-of-concept project aims at building a prototype of an ultra-small optical filter which can be integrated into a semiconductor chip. Spectral filtering is very important for both classical and quantum photonic technology. It has applications in many fields of engineering and science such as telecommunications and spectroscopy. Conventional methods to filter light, such as prisms and gratings, require a very large dispersion length (centimeters to meters) to achieve high wavelength ",{"id":486,"funder":7,"programme":8,"title":487,"piName":10,"institution":488,"country":61,"year":13,"amount":489,"abstract":490},"cordis-european-research-council-award-789601","KiD: A low-cost KInematic Detector to assist early diagnosis and objective profiling of ASD","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","€148,413","Autism spectrum disorders (ASDs) are a heterogeneous set of neurodevelopmental disorders characterized by deficits in social communication and reciprocal interactions, as well as stereotypic behaviours.  Although early diagnosis followed by appropriate intervention appears to offer the best chance for significant health improvement and economic gain, diagnosis of autism remains complex and often difficult to obtain. Recent identification of atypical kinematic patterns in children and infants at ",{"id":492,"funder":7,"programme":8,"title":493,"piName":10,"institution":494,"country":25,"year":13,"amount":495,"abstract":496},"cordis-european-research-council-award-789825","BioMusical Instrument","GOLDSMITHS' COLLEGE","€149,901","The BioMusical Instrument project will create a product prototype of a wearable digital musical instrument based on biosignals from the performer’s muscles. It will allow musicians to perform electronic sounds from bodily gestures. Muscle tension will be sensed by innovative new electromyogram sensing hardware packaged in an ergonomic housing and coupled to wireless communication. Sophisticated machine learning methods developed in the ERC MetaGesture Music and H2020 Rapid-Mix projects will trac",{"id":498,"funder":7,"programme":8,"title":499,"piName":10,"institution":500,"country":116,"year":13,"amount":501,"abstract":502},"cordis-european-research-council-award-727227","Fast Proof Reading and Correction of Complex Delineations","ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE","€149,648","This project aims at turning the novel approach to automated delineation of complex curvilinear structures we have developed under ERC funding into industrial-grade software that can be commercialized. Our primary goal will therefore be to transform our research software into user-friendly plugins with well-defined APIs that can be bundled with widely used commercial software platforms.  In the neuroscience and biomedical    areas,   we    have   identified    three   such platforms and will exp",{"id":504,"funder":7,"programme":8,"title":505,"piName":10,"institution":500,"country":116,"year":13,"amount":14,"abstract":506},"cordis-european-research-council-award-790169","Towards matchbox-size GHz femtosecond lasers for frequency combs generation: ‘a femtosecond laser fabricating a femtosecond laser’","Femtosecond laser GHz cavity lasers has enabled a new type of optical frequency comb that have defined a new standard and a universal method for precisely measuring optical frequencies measuring. This quantum leap in metrology unravelled numerous technological innovations, from more precise atomic clocks to unprecedented data-transmission flowrate in telecoms. So far, optical frequency-comb systems remain table-top size and expensive, an impediment for further adoptions of this major technologic",{"id":508,"funder":7,"programme":8,"title":509,"piName":10,"institution":500,"country":116,"year":13,"amount":14,"abstract":510},"cordis-european-research-council-award-790341","Commercial feasibility assessment of the first single-photon detector for CT","The reduction of radiation exposure in Computed Tomography (CT) remains a pressing medical need in radiology and a major growth opportunity for the medical imaging industry. As part of our ERC research, we have identified a novel method to produce crystalline, photo-sensitive nanowires. These nanowires show a remarkable sensitivity, nearing single-photon detection; about 100 times better than current detectors. This could cause a seismic shift in medical imaging as it will drastically increase t",{"id":512,"funder":7,"programme":8,"title":513,"piName":10,"institution":500,"country":116,"year":13,"amount":14,"abstract":514},"cordis-european-research-council-award-768910","ViDaR: R-enabled large-scale data analytics in ViDa","In this project we will build ViDaR, an interface for integrating R with ViDa. R is among the leading data analytics environments (the leading open-source), and is heavily used by data and domain scientists and data analysts in their daily routine. ViDa, developed by an ERC grant, is the state-of-the-art query engine for raw data. It relies on data virtualization, i.e., abstracting data out of its form and manipulating it regardless of the way it is stored or structured, to enable efficient, sca",{"id":516,"funder":7,"programme":8,"title":517,"piName":10,"institution":500,"country":116,"year":13,"amount":518,"abstract":519},"cordis-european-research-council-award-790654","Commercialization of novel soft neural interfaces","€149,994","E-DURA aims to assess the commercial viability of a new class of soft, multimodal neural implants called e-dura. Current technologies are rigid and present physical, electrochemical and biological mismatches that prevent prolonged periods of implantation. Our technology represents a significant improvement over state-of-art on all those criteria. Moreover, our extensive network of academics and industry professionals represents an advantage in commercializing e-dura, thereby addressing a market ",{"id":521,"funder":7,"programme":8,"title":522,"piName":10,"institution":523,"country":25,"year":13,"amount":14,"abstract":524},"cordis-european-research-council-award-790458","From discovery to scale up of cluster based electrolytes for Ultra-high energy storage flow batteries","UNIVERSITY OF GLASGOW","Large scale energy storage demands are set to increase dramatically during the next years due to the expansion of renewables. One of the most promising large-scale electrical storage technologies are Redox Flow Battery (RFB) systems, which can convert electrical energy to chemical energy and back again. Here the electrolyte is an electro-active species where the chemical energy is converted to electricity in a flow cell. RFBs can act as both batteries and a fuel generation device depending on th",{"id":526,"funder":7,"programme":8,"title":527,"piName":10,"institution":31,"country":25,"year":13,"amount":528,"abstract":529},"cordis-european-research-council-award-790400","Nanozymes POC","€148,646","Point-of-care biosensing technologies often suffer from low sensitivity, specificity, affordability and simplicity. Within Nanozymes POC we are exploiting a lateral flow immunoassay point-of-care technology supported from the ERC award Naturale CG. Our paper-based point-of-care device comprises a lateral flow immunosorbent assay showing a sensitivity of 100pg\u002FmL p24 detection and a 100-fold improvement in sensitivity following a catalytic development step involving platinum core-shell nanopartic",{"id":531,"funder":7,"programme":8,"title":532,"piName":10,"institution":254,"country":25,"year":13,"amount":533,"abstract":534},"cordis-european-research-council-award-778616","Optical NanoActuators for Nanomachines and Microfluidic Chips","€144,549","Over the past 2 years we have developed and patented a new actuator which is based on composite polymer\u002Fmetal nanoparticles. Originally designed to create strong reversible colour changes, we found that the forces generated in the actuation exceed current microscale devices by nearly two orders of magnitude (weight for weight). We have thus protected and developed this possibility using my Advanced ERC project, LINASS, together with Cambridge Enterprise (CE, the commercialisation arm of the Univ",{"id":536,"funder":7,"programme":8,"title":537,"piName":10,"institution":538,"country":61,"year":13,"amount":14,"abstract":539},"cordis-european-research-council-award-780807","Commercialization of a first in class multiple sclerosis drug","UNIVERSITA DEGLI STUDI DI PERUGIA","Multiple sclerosis (MS) is a chronic and progressive neurodegenerative disease that is currently affecting 2.3 million people worldwide. Incidence rates of MS are significantly higher in Europe and in other regions located within the northern hemisphere. In Europe, the number of patients currently afflicted with MS is estimated to be at 700,000, with incidence rates ranging from 2.3-12.2\u002F100,000 per year. GlobalData assessed the market value for MS treatments in 10 major markets (France, Germany",{"id":541,"funder":7,"programme":8,"title":542,"piName":10,"institution":543,"country":116,"year":13,"amount":14,"abstract":544},"cordis-european-research-council-award-812672","Fake news detection in social networks using geometric deep learning","UNIVERSITA DELLA SVIZZERA ITALIANA","In the past decade, social media have become one of the main sources of news for people around the world. Yet, it comes with the danger of exposure to intentionally false information. The extensive spread of fake news has recently become a centerpiece of controversy following the highly debated elections of President Donald Trump and the Brexit vote. It is alleged that the outcome of these votes resulted from the public opinion manipulation by a massive injection of fake news, possibly sponsored",{"id":546,"funder":7,"programme":8,"title":547,"piName":10,"institution":548,"country":25,"year":13,"amount":549,"abstract":550},"cordis-european-research-council-award-812806","Microbiological fluorescence observatory for antibiotic resistance tracking","THE UNIVERSITY OF EXETER","€149,249","The accurate quantification of microbial populations is critical for understanding how microbes evolve and adapt to stressful environments. This, in turn, can help improve rationales for drug deployment aimed at minimising the evolution of antibiotic resistance. Working on ERC-funded research into how microbial communities optimise their virulence traits and mediate drug-resistance, our team identified a need for a low cost photometry device capable of high-throughput quantification of microbial",{"id":552,"funder":7,"programme":8,"title":553,"piName":10,"institution":548,"country":25,"year":13,"amount":554,"abstract":555},"cordis-european-research-council-award-777845","Forefront UAV Technology for Underpinning Rainforest Environmental Sustainability","€149,938","The proposed FUTURES project will use the novel UAV-Lidar technology conceived and developed in the current ERC-funded PAST project, in collaboration with the Brazilian National Institute for Space Research, in an entirely different socio-economic application aimed at helping Extractive Reserves (RESEXs) of the Brazilian Amazon. FUTURES proposes to utilise the UAV-Lidar system for creating 3D maps of forest structure and ground digital terrain models with unprecedented detail and interpret these",{"id":557,"funder":7,"programme":8,"title":558,"piName":10,"institution":559,"country":12,"year":13,"amount":14,"abstract":560},"cordis-european-research-council-award-787487","OsciLang: A neurofeedback system based on oscillatory activity for diagnosis and intervention in language and reading impairments","BCBL BASQUE CENTER ON COGNITION BRAIN AND LANGUAGE","The goal of OsciLang is to provide an affordable, lightweight, wearable brain-computer-interface neurofeedback system that can facilitate the detection and treatment of language disorders such as dyslexia and specific language impairment (SLI).  To date there is no established neurofeedback protocols for treating language or reading impairments. In essence, this tool will (a) diagnose\u002Fmeasure and (b) improve\u002Frehabilitate an individual’s ability to synchronize their brain’s activity with changes ",{"id":562,"funder":7,"programme":8,"title":563,"piName":10,"institution":564,"country":61,"year":13,"amount":565,"abstract":566},"cordis-european-research-council-award-780386","VERA: Extracellular VEsicles, miRNAs and particulate Air pollution: developing a new tool to identify subjects with high exposure-associated cardiovascular risk","UNIVERSITA DEGLI STUDI DI MILANO","€149,939","Air pollution exposure, in particular the particulate matter (PM) component, has been consistently linked to an increased risk of developing acute and chronic cardiovascular diseases (CVD). The SPHERE (Susceptibility to Particle Health Effects, miRNAs and Exosomes) project was granted by ERC-2011-StG 282413 and hosted by the “Università degli Studi”, Milan, Italy, to examine possible molecular mechanisms underlying the effects of PM exposure in relation to health outcomes. In this project, in pa",{"id":568,"funder":7,"programme":8,"title":569,"piName":10,"institution":570,"country":91,"year":13,"amount":10,"abstract":571},"cordis-european-research-council-award-789788","Optical sensing of relative humidity using photoswitchable molecules","TAMPEREEN KORKEAKOULUSAATIO SR","Precise control over humidity and moisture levels is pertinent for various industrial processes dealing with, e.g., chemical engineering and fabrication of pharmaceuticals and semiconductor devices. In order to improve the product yields and ensure safety and high quality, accurate and reliable humidity sensing is in great demand. The dominant humidity-sensing technologies in the market are based on permittivity changes in a polymer matrix induced by water adsorption from air, resulting in chang",{"id":573,"funder":7,"programme":8,"title":574,"piName":10,"institution":575,"country":54,"year":13,"amount":576,"abstract":577},"cordis-european-research-council-award-786330","Development of a tool kit to investigate protein ubiquitylation in biomedical research","INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH","€149,900","Protein ubiquitylation plays a key role in determining the function and fate of proteins in virtually every biological pathway. The deregulation of such fundamental processes causes various diseases, such as cancer, neurodegeneration and inflammation. Understanding the impact of ubiquitylation is therefore critical for improving human health and welfare. Ubiquitin signalling is predominantly mediated by polyubiquitin chains of distinct linkages. Yet, this process is still poorly understood, larg",{"id":579,"funder":7,"programme":8,"title":580,"piName":10,"institution":581,"country":54,"year":13,"amount":576,"abstract":582},"cordis-european-research-council-award-780730","Disseminating N-terminomics to Advance Protease Research","UNIVERSITAETSKLINIKUM FREIBURG","Protein N-termini represent a wealth of biological information, such as their generation by limited proteolysis, which sculpts proteome functionality by yielding protein-sized cleavage products with novel functionality. N-terminomics is a branch of functional proteomics and enables the analysis of thousands of protein N-termini in an unbiased manner. By targeting native, proteolytically generated or acetylated protein N-termini as well as uncovering novel translation initiation sites, N-terminom",{"id":584,"funder":7,"programme":8,"title":585,"piName":10,"institution":586,"country":54,"year":13,"amount":587,"abstract":588},"cordis-european-research-council-award-790559","Switchable adhesives for the robotics and handling market","INM - LEIBNIZ-INSTITUT FUER NEUE MATERIALIEN GEMEINNUETZIGE GMBH","€147,125","Despite intense fundamental research, only few biological inspirations have so far made it to real technical solutions. The reason is that the path from an understanding of nature to a successful product has many potential ´show stoppers´. The ERC Advanced Grant SWITCH2STICK addresses the scientific challenges and does not aim at product development and targeted technical optimization towards industrial requirements. Some preliminary industrial contacts, established through bilateral communicati",{"id":590,"funder":7,"programme":8,"title":591,"piName":10,"institution":592,"country":25,"year":13,"amount":593,"abstract":594},"cordis-european-research-council-award-789863","Combined waste heat recovery and compact cooling with Pyroelectric-Oscillating Heat Pipe (POHP) system for low temperature thermal to electrical energy conversion","UNIVERSITY OF BATH","€149,424","This Proof of Concept will exploit pyroelectric harvesting in the emerging market of oscillating heat pipes (OHPs) that can be used for cooling of electronics, lighting, solar panel and batteries.  The application areas for oscillating heat pipes include thermal management of microprocessors, mobile computing devices, and LEDs, which all require small heat transfer devices. Larger electronic systems that require cooling include voltage transformers and current rectifiers, since most of the moder",{"id":596,"funder":7,"programme":8,"title":597,"piName":10,"institution":598,"country":91,"year":13,"amount":14,"abstract":599},"cordis-european-research-council-award-812837","Fabricating Functional Components in Room Temperature","OULUN YLIOPISTO","Electroceramics are key materials in all electronics. These ceramic components are used for example in sensing of force, acceleration, and humidity, in energy harvesting, and in frequency tuning of antennas and filters. They are also used for miniaturization and packaging of electronics systems and devices. The main disadvantage of electroceramics is that the fabrication requires relatively high investments and it consumes significant amount of energy due to high sintering temperatures (850-2000",{"id":601,"funder":7,"programme":8,"title":602,"piName":10,"institution":215,"country":12,"year":13,"amount":169,"abstract":603},"cordis-european-research-council-award-825836","Colorectal Cancer Mouse Tumor Organoids as Pre-clinical Models for Therapeutical Testing","Colorectal cancer (CRC) is one of the leading causes of death by cancer, which is largely associated to metastatic spread of the disease. Progress to develop efficient therapies, including immunotherapies, for patients with metastatic CRC has been hampered by the lack of preclinical models to study late stage CRC in an immunocompetent background.  We have developed the first genetic mouse model of advanced CRC in immunocompetent mice. This model is based in a biobank of mouse tumor organoids (MT",{"id":605,"funder":7,"programme":8,"title":606,"piName":10,"institution":307,"country":97,"year":13,"amount":14,"abstract":607},"cordis-european-research-council-award-825761","Enhancing biological drug production through protein secretion","Biotherapeutics are bio-materials, which are used among others to treat cancer, diabetes, and rare diseases. It is expected that these medicines will make up half of the medicines in future. Already now, 350 million patients are treated with biotherapeutics, produced from proteins. The proteins that are injected to humans must be “clean” and pure. However, harvesting a protein from cells and purifying it is a daunting challenge. Current harvesting methods are complicated and expensive.We made a ",{"id":609,"funder":7,"programme":8,"title":610,"piName":10,"institution":611,"country":25,"year":13,"amount":612,"abstract":613},"cordis-european-research-council-award-812917","Compound-Specific Radiocarbon Analysis to Date Prehistoric Human Cultural Change","UNIVERSITY OF BRISTOL","€149,940","Pottery typology is the principal method used to date archaeological sites, however, the approach provides relative ratherthan absolute dates. Paradoxically, 14C dating using accelerator mass spectrometry (AMS) is the technique used to assignabsolute or calendrical dates, but pots, being fabricated from fired clay, i.e. aluminosilicate, lack endogenous organiccarbon and so cannot be 14C dated directly. Carbonaceous tempers, amorphous residues adhering to the surface andcarbon-based materials co-",{"id":615,"funder":7,"programme":8,"title":616,"piName":10,"institution":437,"country":198,"year":13,"amount":14,"abstract":617},"cordis-european-research-council-award-813236","Free-space optical transmission links with unprecedented receiver sensitivity","Free-space optical communication links provide higher capacity and smaller beam divergence than their radio-frequency counterpart, and are increasingly being used for relatively short links often established for temporary purposes (e.g. outdoor sporting and concert events). They are also explored for extremely long reaches (e.g. between satellites, to the moon and beyond). In both cases, the sensitivity is fundamentally limited by the effect of diffraction, which results in the divergence of a f",{"id":619,"funder":7,"programme":8,"title":620,"piName":10,"institution":621,"country":622,"year":13,"amount":354,"abstract":623},"cordis-european-research-council-award-812703","A redox-neutral process for the cost-efficient and environmentally friendly production of Menthol","UNIVERSITAT WIEN","AT","Menthol is an organic compound which ranks as the world's most popular flavour due to its uniquely fresh taste. It is present in a myriad of everyday products, from shower gel to toothpaste to cooling ointment. It is most widely produced industrially from Citronellal in a sequence of metal-promoted cyclisation followed by precious metal-catalysed hydrogenation.  The use of metals in synthesis presents issues associated with cost, environmental friendliness and product contamination.  In the ERC ",{"id":625,"funder":7,"programme":8,"title":626,"piName":10,"institution":133,"country":134,"year":13,"amount":627,"abstract":628},"cordis-european-research-council-award-766544","Isolation of rare circulating tumor cells","€149,375","In 2013 I was awarded an ERC consolidator grant to pursue a novel cancer targeting concept using a recombinant malaria protein. As an ERC grantee I verified the malaria protein (rVAR2) binds to this distinct cancer expressed molecule (CSA) in hundreds of cancer cell lines and thousands of tissue biopsies. Our research demonstrate a pivotal role of CSA in cancer cell migration and thus in the formation of metastasis. Circulating tumor cells (CTCs) are cancer cells escaping the primary tumor with ",{"id":630,"funder":7,"programme":8,"title":631,"piName":10,"institution":632,"country":54,"year":13,"amount":14,"abstract":633},"cordis-european-research-council-award-780669","Functional Blood Analysis for Clinical Application in Sepsis","ZELLMECHANIK DRESDEN GMBH","We want to prepare the commercialisation of a novel clinical diagnostic test for the status of the immune system – the mechanical haemogram – with the purpose of improving the therapy management of severe infections, in particular in case of sepsis. Sepsis is ranked the third most common cause of death worldwide, and represents one of the most challenging problems even in modern health care systems. Our test is based on the analysis of single cell mechanical properties of white blood cells found",{"id":635,"funder":7,"programme":8,"title":636,"piName":10,"institution":637,"country":91,"year":13,"amount":14,"abstract":638},"cordis-european-research-council-award-755037","Novel algorithm for treatment planning of patients with osteoarthritis","ITA-SUOMEN YLIOPISTO","Osteoarthritis (OA) is a common joint disease affecting over 40 million Europeans. Most common consequences of OA are pain, disability and social isolation. What is alarming, the number of patients will increase 50% in developed countries during the next 20 years. Moreover, the economic costs of OA are considerable since 1) direct healthcare (hospital admissions, medical examinations, drug therapy, etc.) and 2) productivity costs due to reduced performance while at work and absence from work hav",{"id":640,"funder":7,"programme":8,"title":641,"piName":10,"institution":237,"country":163,"year":13,"amount":14,"abstract":642},"cordis-european-research-council-award-779939","Smart wavy patterned implants with instructive properties for tissue regeneration by controlling the degree of fibers buckling.","In the pursuit for engineering CELL HYBRIDGE regenerative medicine implants able to regenerate skeletal tissues by controlling adult stem cell activity, we have developed an innovative method to successfully improve cell migration into electrospun scaffolds. Whereas this has a direct impact in CELL HYBRIDGE as part of the planned activities, we unexpectedly discovered that the same scaffolds display wavy patterns that have a direct influence on cell differentiation by enhancing their intrinsic c",{"id":644,"funder":7,"programme":8,"title":645,"piName":10,"institution":523,"country":25,"year":13,"amount":646,"abstract":647},"cordis-european-research-council-award-790380","Synergistic growth factor microenvironments for veterinary bone regeneration.","€149,973","We propose a system that allows a safer delivery of recombinant human bone morphogenetic protein-2 (rhBMP2) for bone tissue engineering and have planned a veterinary trial in relevant conditions. We have teamed up with a team of veterinary surgeons and several industry and clinical partners for the appraisal of the proposal from a translational standpoint. rhBMP2 is a powerful growth factor (GF) essential in tissue morphogenesis and used to promote bone growth in clinical applications. Current c",{"id":649,"funder":7,"programme":8,"title":650,"piName":10,"institution":377,"country":265,"year":13,"amount":14,"abstract":651},"cordis-european-research-council-award-825783","Software Enhanced Research iN Transient kinetics","The microKinetic Engine (μKE), an existing user-friendly software for steady-state simulation purposes which is ready for commercialization, will find a totally new application area by incorporating the ability to account for important transient occurrences commonly encountered in industry, e.g., startup, shutdown and perturbations of the continuous flow reactor operation. The implementation of a transient solution strategy will also render the software more robust, even for steady-state simulat",{"id":653,"funder":7,"programme":8,"title":654,"piName":10,"institution":475,"country":61,"year":13,"amount":14,"abstract":655},"cordis-european-research-council-award-825879","Industrial implementation of a step-change technology to measure fluorescence","The FLUO proposal aims at bringing to the market a revolutionary device to measure fluorescence of a large variety of samples. Fluorescence is the property of molecules to emit radiation after being illuminated by an excitation light (usually in the ultraviolet). Fluorescence is a powerful analytical tool employed in many fields such as life science, biology, biotechnology, pharmacology, medical diagnostics, food industry, chemistry, photovoltaics and environment safety. Different chemical speci",{"id":657,"funder":7,"programme":8,"title":658,"piName":10,"institution":659,"country":12,"year":13,"amount":660,"abstract":661},"cordis-european-research-council-award-790429","Valorisation of splice-switching oligonucleotides for lung cancer therapy","FUNDACIO CENTRE DE REGULACIO GENOMICA","€149,894","Here we propose to test the therapeutic potential of a novel class of reagents, known as splicing-modifying antisense oligonucleotides, in preclinical models of lung adenocarcinoma, including patient-derived tumours in mice. Alternative splicing is a major mechanism of gene regulation by which different messenger RNAs and proteins are generated from a single gene, often displaying distinct, even antagonistic functions. Alterations in alternative splicing have been linked with a plethora of patho",{"id":663,"funder":7,"programme":8,"title":664,"piName":10,"institution":96,"country":97,"year":13,"amount":14,"abstract":665},"cordis-european-research-council-award-813258","Bioinspired superhydrophbic wax surfaces to eliminate biofilm formation in the food industry","Microbial food spoilage leads to food-borne illnesses and food wastage.  It is estimated that food borne disease cause 23 million illnesses and 5,000 deaths only in the European region   and around 88 million tonnes of food are wasted annually. Contamination of food by biofilms can occur at any stage of the food production process or consumption. In this PoC we propose to address this problem taking inspiration from nature. We have shown that we can emulate various plant leaf surfaces by synthet",{"id":667,"funder":7,"programme":8,"title":668,"piName":10,"institution":669,"country":48,"year":13,"amount":14,"abstract":670},"cordis-european-research-council-award-787462","The Precompetitive Steps of Virtual Transparency and Augmented Laparoscopy","UNIVERSITE CLERMONT AUVERGNE","Laparoscopy allows the surgeons to treat pathologies such as cancer with considerably less trauma for the patient than classical open surgery. The laparoscope is a small camera inserted in the patient’s abdominopelvic cavity. Laparoscopy has been used for decades but still suffers from the impossibility of seeing the organs’ inner anatomy. This forms an important limitation because it slows down surgery, prevents finding some tumors and dramatically limits the use of laparoscopy. ViTAL (Virtual ",{"id":672,"funder":7,"programme":8,"title":673,"piName":10,"institution":254,"country":25,"year":13,"amount":238,"abstract":674},"cordis-european-research-council-award-780645","Graphene-based High Resolution Neural Interfaces for ICT-inspired Neuro-treatment","Electronic devices enabling communication with human nervous system are becoming increasingly prevalent, offering novel information and communication (ICT)-based treatment techniques to help people overcome various disorders ranging from spinal cord injuries (SCIs) to missing limbs. Millions of people worldwide suffer from such ailments with a cumulative cost to the society estimated in billions of Euros annually. Next-generation ICT-based treatment techniques demand for interfaces with higher s",{"id":676,"funder":7,"programme":8,"title":677,"piName":10,"institution":307,"country":97,"year":13,"amount":14,"abstract":678},"cordis-european-research-council-award-811249","Protected starter cultures for the dairy industry","Milk and its fermentation derivatives, yogurt and cheese, are globally consumed at rates of >750 million tonnes annually, and are responsible for ~10% of the protein consumption worldwide. In the process of yogurt and cheese production, starter cultures of lactic acid bacteria (LAB) are added to milk, leading to fermentative production of the end product. Optimal growth of the lactic acid bacteria within the milk is critical for high-quality fermentation in the manufacturing of such dairy produc",{"id":680,"funder":7,"programme":8,"title":681,"piName":10,"institution":682,"country":116,"year":13,"amount":683,"abstract":684},"cordis-european-research-council-award-768598","Development of a compact, user-friendly and cost effective source for the generation of powerful and broad ultrashort pulses in the deep-UV","UNIVERSITAET BERN","€140,625","Here we present an original design of a compact and portable set-up able to generate very broadband (70-100 nm at 300 nm) and powerful (>1uJ\u002Fpulse) ultrashort deep-UV pulses. Compared with other schemes, it guarantees an aberration-free propagation, an easy installation and minimal dispersion. The present project aims to bring the current prototype to the level of a commercial device. The conceived design will allow to manufacture a compact, portable and cost effective device, which will be user",{"id":686,"funder":7,"programme":8,"title":687,"piName":10,"institution":475,"country":61,"year":13,"amount":14,"abstract":688},"cordis-european-research-council-award-825159","Miniaturised optically accessible bioreactor for drug discovery and biological research","The problem that we address is that the pharmaceutical companies do not develop radically new drugs anymore, because the development process lasts ten years and costs around one billion euro. Development of a new drug is subjected to regulatory approvals following three demonstrations: lab discovery in vitro, animal testing in vivo and clinical trial on patients. This process has 99.9% overall failure, of which 96.4% because the drug efficacy measured in vitro is not confirmed in animals. In fac",{"id":690,"funder":7,"programme":8,"title":691,"piName":10,"institution":692,"country":25,"year":13,"amount":693,"abstract":694},"cordis-european-research-council-award-790397","Upgrading waste glycerol to essential chemicals","CARDIFF UNIVERSITY","€146,461","The production of waste glycerol is increasing annually and there is a desire to efficiently upgrade it to more valuable chemicals. In particular glycerol is a bio-derived feedstock and its efficient transformation to essential chemicals is an alternative to using fossil fuel based resources. We have discovered a new-class of catalysts based on active metal nanoparticles supported on perovskite metal oxides. These catalysts are very efficient for the transformation of glycerol to highly desirabl",{"id":696,"funder":7,"programme":8,"title":697,"piName":10,"institution":698,"country":181,"year":13,"amount":14,"abstract":699},"cordis-european-research-council-award-790340","Program Analysis and Reorganization, as a Service","ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON","The PARSE project will explore the potential for wide deployment (and possible commercialization) of whole-program static program analysis techniques as a web-based service for program comprehension and reorganization. This analysis-as-a-service (AaaS) approach will have direct value for a large number of professional programmers. The programmer will use the service to answer key program comprehension questions (including: “how does my code use this open-source library?”; “Am I affected by the s",{"id":701,"funder":7,"programme":8,"title":702,"piName":10,"institution":703,"country":198,"year":13,"amount":14,"abstract":704},"cordis-european-research-council-award-812975","Crack-Defined Nanogap Electrodes for High-Throughput Decoding of DNA","KUNGLIGA TEKNISKA HOEGSKOLAN","Within the ERC Starting Grant project M&M´s we have developed several innovative fabrication and integration technologies for nanoelectromechanical systems (NEMS). In one of these research activities, our ERC team has invented and demonstrated a new methodology for parallel fabrication of electrically conductive electrode pairs separated by sub-2 nm wide gaps, enabling unprecedented fabrication of millions of such nanogap electrodes. To the best of our knowledge, there is no alternative technolo",{"id":706,"funder":7,"programme":8,"title":707,"piName":10,"institution":708,"country":181,"year":13,"amount":709,"abstract":710},"cordis-european-research-council-award-755412","Commercialization of a novel method for fabricating cheap tailor–made superhydrophobic surfaces","ETHNICON METSOVION POLYTECHNION","€149,730","The aim of the HYDROPHO-CHEAP project is to optimize, protect, and commercialize a recently developed methodology that allowed us to achieve “tailor-made” control of the wettability of polymer surfaces, rendering them super water-repellent. What makes our methodology highly innovative is the fast and cheap fabrication process, and most importantly the potential of implementing it in real-life environments. With this unique method we can fabricate ‘superhydrophobic islands’ (with a spatial resolu",{"id":712,"funder":7,"programme":8,"title":713,"piName":10,"institution":714,"country":12,"year":13,"amount":14,"abstract":715},"cordis-european-research-council-award-790163","Lab-in-a-patch for PKU self-assessment","FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA","Phenilketonuria (PKU) is a congenital metabolic disease related to high levels of phenylalanine (Phe) in blood that, if not treated, can lead to intellectual disability, behavioural problems, and mental disorders. Life-long monitoring of Phe levels are necessary for PKU patients to avoid health (mainly neurological) issues. Currently available techniques for Phe assessment are costly, slow and take place only in clinical chemistry laboratories inside tertiary care hospitals, with a total analysi",{"id":717,"funder":7,"programme":8,"title":718,"piName":10,"institution":307,"country":97,"year":13,"amount":14,"abstract":719},"cordis-european-research-council-award-812577","Long-retention liposomic drug-delivery for intra-articular osteoarthritis therapy","Osteoarthritis (OA) is the most widespread joint disease, affecting millions and imposing a huge individual and socio-economic burden.  The creation of liposomes functionalised with novel (IP-protected) molecules that greatly extend (by almost an order of magnitude) their half-life in joints following IA injection, relative to existing approaches, and the alleviation of OA that may arise through exploiting this longer retention, is the basis of this proof of concept project. The main innovation ",{"id":721,"funder":7,"programme":8,"title":722,"piName":10,"institution":621,"country":622,"year":13,"amount":14,"abstract":723},"cordis-european-research-council-award-812766","Short, weakly interacting RNA ligands for the development of high-concentration monoclonal antibody therapeutics","Usage of therapeutic monoclonal antibodies (mAbs) has over the past 20 years become one of the most powerful pharmacological strategies in the treatment of various types of cancer, cardiovascular diseases and autoimmune disorders. Importantly, a central challenge in developing the required high protein concentration formulations of mAb therapeutics is the issue of protein solubility. The current approaches for addressing this challenge typically involve using different osmolyte excipients such a",{"id":725,"funder":7,"programme":8,"title":726,"piName":10,"institution":254,"country":25,"year":13,"amount":14,"abstract":727},"cordis-european-research-council-award-790518","Photonics Cellulose Pigments","The objective of the proposal is to develop a process for large-scale fabrication of a novel class of cellulose-based photonic pigments, which will replace traditional, potentially hazardous colorants that are currently used in industry for cosmetics, food, textiles and security labelling. These novel photonic pigments consist of micron-sized spherical particles composed of naturally-derived cellulose nanocrystals.  Within the remit of the ERC StG SeSaMe, it has been demonstrated that cellulose ",{"id":729,"funder":7,"programme":8,"title":730,"piName":10,"institution":731,"country":12,"year":13,"amount":14,"abstract":732},"cordis-european-research-council-award-779792","Enhancing Separation Efficiency in European Syngas Industry by using Zeolites","UNIVERSIDAD PABLO DE OLAVIDE","Syngas is traditionally used in industry for production of fuels in the kerosene, gasoline and diesel range via Fischer-Tropsch, for the manufacture of bulk chemicals like ammonia, methanol and dimethyl ether and for synthesis of a whole array of fine chemicals. The hydrogen \u002Fcarbon monoxide ratio of the syngas is an important design variable to maximize production of these compounds. Therefore, the search of effective processes that enable said ratio adjustment as well as individual compound pu",{"id":734,"funder":7,"programme":8,"title":735,"piName":10,"institution":736,"country":54,"year":13,"amount":737,"abstract":738},"cordis-european-research-council-award-790423","Image-based analysis for drug discovery and repurposing","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","€149,500","Drug discovery and development has become a lengthy and resource-intensive process which is characterized by high attrition rates of candidate molecules. Candidate molecules are often identified in high-throughput screening experiments that capture only a small fraction of its biological activities and too many candidates fail in clinical development due to unwanted side-effects and lack of a therapeutic window. In addition, many approved drugs harbor unrecognized therapeutic efficacy in other i",{"id":740,"funder":7,"programme":8,"title":741,"piName":10,"institution":742,"country":54,"year":13,"amount":14,"abstract":743},"cordis-european-research-council-award-786445","Point-of-care molecular diagnostics of psoriasis and eczema – peLabDisk","KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)","Innovative and effective biological therapies exist to treat non-communicable inflammatory skin diseases (ncISD). However, diagnostic guidance when and how to use them is imprecise; no substantial innovation was made for decades. Due to this lack of innovation, high socio-economic costs are caused by ineffective unguided treatment – a waste of resources. Existing ERC research aims at establishing individualised medicine in ncISD (IMCIS, grant agreement 676858). First success is a biomarker to di",{"id":745,"funder":7,"programme":8,"title":746,"piName":10,"institution":747,"country":181,"year":13,"amount":14,"abstract":748},"cordis-european-research-council-award-790272","Scalable graphene-gated transistors","NATIONAL CENTER FOR SCIENTIFIC RESEARCH DEMOKRITOS\"","'The GR-GATE project proposes a novel negative quantum capacitance field effect transistor (NQCFET) with steep subthreshold characteristics which enables operation at low power supply voltages (Vdd). The technology can be combined with state of the art Si device architectures such as FDSOI or more mature steep slope switches such as the tunneling field effect transistor (TFET) functioning as technology booster to improve low power \u002Fhigh performance operation characteristics of transistors. The l",{"id":750,"funder":7,"programme":8,"title":751,"piName":10,"institution":752,"country":54,"year":13,"amount":14,"abstract":753},"cordis-european-research-council-award-790668","Innovative cancer management: First in human senescence imaging","EBERHARD KARLS UNIVERSITAET TUEBINGEN","The irreversible growth arrest, termed cellular senescence, plays a key role in tumor progression and promotion, as well as in many other physiological processes. It has been shown to be a predictive marker for the long term outcome of cancer treatment and novel therapies aiming at the elimination of senescent cells are under development (i.e. senolytics). Therefore, techniques for the detection of senescence are of utmost importance. However, in the current clinical setting this is only possibl",{"id":755,"funder":7,"programme":8,"title":756,"piName":10,"institution":757,"country":116,"year":13,"amount":14,"abstract":758},"cordis-european-research-council-award-780151","TOF PET With Strip SiPMs","ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE","TWIST will build detector modules for PET scanners that offer high sensitivity together with precise position and time resolution. TWIST will deliver high-resolution PET images with low background using a lower dosage of radio-tracer. The breakthrough is obtained due to the successful development of the new Strip Silicon PhotoMultiplier (SSiPM) within the ERC TICAL project.PET (Positron Emission Tomography) scanners create images of the distribution of positron emitters in the body of subjects u",{"id":760,"funder":7,"programme":8,"title":761,"piName":10,"institution":460,"country":61,"year":13,"amount":762,"abstract":763},"cordis-european-research-council-award-779604","An innovative screening protocol device for early identification of neonates at high-risk for Autism Spectrum Disorders","€149,936","Autism spectrum disorders (ASD) comprise an early-onset neurodevelopmental syndrome primarily characterized by impairments in social perception, cognition and communication, and a restricted pattern of interests and behavior. Without any doubt, infants and children with ASD greatly benefit from early behavioral intervention, therefore an early detection and treatment of ASD has been placed as a major health care priority. Unfortunately, nowadays, ASD diagnosis occurs at 2.5-4 years of age. In my",{"id":765,"funder":7,"programme":8,"title":766,"piName":10,"institution":767,"country":163,"year":13,"amount":768,"abstract":769},"cordis-european-research-council-award-790079","Tracers for targeting nerves in the autonomic nervous system","ACADEMISCH ZIEKENHUIS LEIDEN","€140,000","\"As a common disease in western men, prostate cancer is a major driver for the billion-euro robotic surgery and laparoscopic devices markets. In the surgical management of prostate cancer patients, next to the tumor resection accuracy, the surgeon’s ability to preserve the nerve-network and prevent erectile dysfunction and urinary incontinence, is key. As these nerves are not visible by eye, image guided surgery approaches aimed at nerve-sparing demand the clinical availability of nerve-specific",{"id":771,"funder":7,"programme":8,"title":772,"piName":10,"institution":192,"country":97,"year":13,"amount":14,"abstract":773},"cordis-european-research-council-award-789758","Negative capacitor based on a ferroelectric nano-dot","One of the most exciting proposed solutions to the approaching limit of down-scaling in microelectronics (so-called “end of Moore’s law”) consists of the use of negative capacitors, [NegCap]s.      When a NegCap is placed between the gate and the channel of a FET (field-effect transistor), the applied voltage on the gate is strongly amplified on the channel. Therefore, it is possible to reduce substantially the applied gate voltage, yet keeping the voltage on the gate sufficiently high for on\u002Fof",{"id":775,"funder":7,"programme":8,"title":776,"piName":10,"institution":307,"country":97,"year":13,"amount":14,"abstract":777},"cordis-european-research-council-award-811305","On-chip optical communication with transformation optics","Transformation optics grew out of ideas for invisibility cloaking and exploits connections between electromagnetism in media and in geometries. This Proof of Concept project uses transformation optics for improving on-chip optical communication in silicon photonics. The goal is reaching a performance that matches industry standards such that the idea becomes sufficiently convincing to be commercialized.",{"id":779,"funder":7,"programme":8,"title":780,"piName":10,"institution":465,"country":48,"year":13,"amount":14,"abstract":781},"cordis-european-research-council-award-825273","ZebraZoom: Kinematic analysis for drug and genetic screening in zebrafish","With millions of European citizens suffering from chronic pain and neurodegenerative disease, there is an urgent need for efficient solutions for drug screening in animal models. Discovery of new drugs and functions of genes involved in these human diseases relies on efficient ways to screen effects on animal behavior and at low cost. Zebrafish emerged in the last decade as an essential model for drug discovery as it is: i) a low cost genetic model organism whose genome shares 70% homology with ",{"id":783,"funder":7,"programme":8,"title":784,"piName":10,"institution":145,"country":25,"year":13,"amount":14,"abstract":785},"cordis-european-research-council-award-825706","Structuring Raw Scans","Many massive data sources now exist for large scale 3D measurements in the form of raw pointclouds or polygonal soups. Such raw data, however, have to be cleaned, consolidated, and semantically annotated before they can be consumed by downstream applications (e.g., augmented reality, procedural modeling, energy simulation, etc.). This manual step is a major processing bottleneck resulting in significant economic and efficiency costs. For example, state-of-the-art workflows in location-based serv",{"id":787,"funder":7,"programme":8,"title":788,"piName":10,"institution":789,"country":116,"year":13,"amount":790,"abstract":791},"cordis-european-research-council-award-825833","An autonomous Real-Time Decision Tree framework for monitoring and diagnostics on wind turbines","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","€148,890","Operation & Maintenance (O&M) costs may account for 30 % of the total cost of energy for offshore wind power. Alarmingly, only after a few years of installation, offshore wind turbines (WT) may need emergency repairs. They also feature an extremely short lifespan hindering investments to green energy, effectively designed to reduce CO2 emissions.We have designed real-time monitoring and diagnostics platform in the context of operation and maintenance scheduling of WT components. Using this archi",{"id":793,"funder":7,"programme":8,"title":794,"piName":10,"institution":611,"country":25,"year":13,"amount":14,"abstract":795},"cordis-european-research-council-award-787173","Barrel Array Diagnostics And SenSing","In array-based sensing, synthetic receptors are appended with chromophores (reporters) and arrayed in various formats. The arrays are treated with analytes that displace the reporter to different extents and the outputs are interpreted by computers to identify the analyte. This has not been demonstrated for arrays of structured de novo designed peptides, which have many advantages over the synthetic small molecules currently used. Through an ERC Advanced Grant, ABEL (340764), we have designed pe",{"id":797,"funder":7,"programme":8,"title":798,"piName":10,"institution":799,"country":334,"year":13,"amount":10,"abstract":800},"cordis-european-research-council-award-812792","A long-lasting non-migrating hydrogel for relieving chronic pain","UNIVERSITY OF GALWAY","Chronic Neuropathic Pain (NeP) is an enormous problem globally. Estimates predicate that 20% of adults suffer from pain world-wide and 10% are newly diagnosed with chronic pain annually1. According to the EuroPain Innovative Medicines Initiative (IMI)2, one in five adults in Europe suffers from chronic pain.  One type of Neuropathic Pain that is particularly detrimental to patients quality of life is Trigeminal Neuralgia (TN). The trigeminal nerve is responsible for facial sensory function, and ",{"id":802,"funder":7,"programme":8,"title":803,"piName":10,"institution":804,"country":805,"year":13,"amount":14,"abstract":806},"cordis-european-research-council-award-780915","Commercialising a novel glioblastoma targeted therapy and a companion diagnostic compound","TARTU ULIKOOL","EE","Glioblastoma (GBM), is the most aggressive form of primary brain cancer and is diagnosed in 22,000 people per year in the EU. GBM is the most aggressive primary brain cancer and, by annual incidence, the most common type of malignant brain tumour. Despite aggressive treatment, the cancer always recurs. The average survival after diagnosis is 12 to 15 months, with less than 3% to 5% of patients surviving longer than 5 years. The current standard of care extends overall survival to ~14 -16 months.",{"id":808,"funder":7,"programme":8,"title":809,"piName":10,"institution":810,"country":163,"year":13,"amount":14,"abstract":811},"cordis-european-research-council-award-790088","Instrument Shape Sensing for Minimally Invasive Interventions","UNIVERSITEIT TWENTE","Percutaneous insertions of instruments are commonly used during minimally invasive surgery (MIS) for delivering diagnostic agents and performing therapeutic interventions. These instruments often deviate from their intended paths due to tissue deformation and physiological processes. Inaccurate instrument placement may lead to misdiagnosis, ineffective therapy, or traumatic effects due to medical complications. The ability to accurately visualize the instrument in real-time, without providing to",{"id":813,"funder":7,"programme":8,"title":814,"piName":10,"institution":815,"country":25,"year":13,"amount":14,"abstract":816},"cordis-european-research-council-award-789182","Solvent free Cryopreservation of Hematopoietic Stem Cells","UNIVERSITY OF WARWICK","This proof of concept grant will revolutionise how bone marrow stem cells are cryopreserved by translating ERC-grant developed technology, inspired by how organisms survive in extreme cold temperatures. Bone marrow (haematopoietic) stem cells are used in life saving treatments, especially for blood cancers such as Leukaemia, but have potential for a wide range of diseases. The current method for storing stem cells involves addition of huge amounts of toxic organic solvents which leads to unwante",{"id":818,"funder":7,"programme":8,"title":819,"piName":10,"institution":145,"country":25,"year":13,"amount":820,"abstract":821},"cordis-european-research-council-award-780143","Village Invest: Low Cost Loans for Unbanked People in Risky Political Economies","€145,926","Drawing on research from AISMA (An Anthropological Investigation of Muscular Politics in South Asia) on systematic corruption and bossism we propose to develop a proof of concept which tests the technical feasibility and commercial viability of an innovative online digital lending platform (‘Village Invest, Inc.’). The proof of concept will take place  over an eighteen-month period. The pilot testing will be conducted in India. ‘Village Invest’ is a start-up social enterprise that aims to provid",{"id":823,"funder":7,"programme":8,"title":824,"piName":10,"institution":538,"country":61,"year":13,"amount":14,"abstract":825},"cordis-european-research-council-award-813099","MicroTher: Drug Discovery from the Microbiota","The rapid increase in the prevalence of diseases caused by the disruption of the intestinal epithelium, also known as leaky gut syndrome, is a global cause for concern. Metabolic syndrome (MetSyn) and inflammatory bowel syndrome (IBS), two disease indications that occur as a result of a compromised intestinal mucosal membrane, collectively effect over 235 million people globally. In a healthy gut, the epithelial lining is tightly aligned to form a structurally robust barrier between the outside ",{"id":827,"funder":7,"programme":8,"title":828,"piName":829,"institution":830,"country":163,"year":13,"amount":10,"abstract":831},"openalex-european-research-council-award-erc-poc-201x-931306","Overnight worsening of emotional distress indicates maladaptive sleep in insomnia","Rick Wassing","Netherlands Institute for Neuroscience","Our findings are the first to experimentally show that the benefits of sleep are not only lost when sleep is poor; people with insomnia experience a maladaptive type of sleep that actually aggravates physically perceived distress. Maladaptive sleep could shed new light on posttraumatic stress disorder (PTSD) and on diurnal mood fluctuation and the counterintuitive favorable effects of sleep deprivation in depression.",{"id":833,"funder":7,"programme":8,"title":834,"piName":835,"institution":836,"country":163,"year":13,"amount":10,"abstract":837},"openalex-european-research-council-award-erc-poc","Potentiation of cerebellar Purkinje cells facilitates whisker reflex adaptation through increased simple spike activity","Vincenzo Romano","Erasmus MC","Cerebellar plasticity underlies motor learning. However, how the cerebellum operates to enable learned changes in motor output is largely unknown. We developed a sensory-driven adaptation protocol for reflexive whisker protraction and recorded Purkinje cell activity from crus 1 and 2 of awake mice. Before training, simple spikes of individual Purkinje cells correlated during reflexive protraction with the whisker position without lead or lag. After training, simple spikes and whisker protraction",{"id":839,"funder":7,"programme":8,"title":840,"piName":841,"institution":842,"country":91,"year":13,"amount":10,"abstract":843},"openalex-european-research-council-award-erc-poc-2018-812841-powerspin","Propagating spin waves in nanometer-thick yttrium iron garnet films: Dependence on wave vector, magnetic field strength, and angle","Huajun Qin","Aalto University","We present a comprehensive investigation of propagating spin waves in nanometer-thick yttrium iron garnet (YIG) films. We use broadband spin-wave spectroscopy with integrated coplanar waveguides (CPWs) and antennas on top of continuous and patterned YIG films to characterize spin waves with wave vectors up to 10 $\\mathrm{rad}\u002F\\ensuremath{\\mu}\\mathrm{m}$. All films are grown by pulsed laser deposition. From spin-wave transmission spectra, parameters such as the Gilbert damping constant, spin-wave",160,{"programme":8,"total":846,"withPiName":847,"firstYear":848,"lastYear":849,"countryCount":850,"perYear":851,"topInstitutions":889,"topCountries":957},2347,7,2014,2027,31,[852,854,857,859,862,863,866,869,872,875,878,881,884,887],{"year":848,"count":853},13,{"year":855,"count":856},2015,142,{"year":858,"count":856},2016,{"year":860,"count":861},2017,200,{"year":13,"count":844},{"year":864,"count":865},2019,176,{"year":867,"count":868},2020,174,{"year":870,"count":871},2021,120,{"year":873,"count":874},2022,198,{"year":876,"count":877},2023,231,{"year":879,"count":880},2024,237,{"year":882,"count":883},2025,265,{"year":885,"count":886},2026,264,{"year":849,"count":888},25,[890,893,896,899,902,905,908,911,914,916,918,921,924,927,929,932,935,937,940,942,944,946,949,952,954],{"name":891,"count":892},"Centre National de la Recherche Scientifique CNRS",84,{"name":894,"count":895},"Weizmann Institute of Science",65,{"name":897,"count":898},"Technion - Israel Institute of Technology",43,{"name":900,"count":901},"The Chancellor Masters and Scholars of the University of Cambridge",42,{"name":903,"count":904},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",41,{"name":906,"count":907},"Fondazione Istituto Italiano di Tecnologia",34,{"name":909,"count":910},"Tel Aviv University",33,{"name":912,"count":913},"Imperial College of Science Technology and Medicine",32,{"name":915,"count":913},"Politecnico di Milano",{"name":917,"count":850},"Institut National de la Sante Et de la Recherche Medicale",{"name":919,"count":920},"Ecole Polytechnique Federale de Lausanne",30,{"name":922,"count":923},"Universiteit Twente",29,{"name":925,"count":926},"The Hebrew University of Jerusalem",28,{"name":928,"count":926},"Universiteit Gent",{"name":930,"count":931},"The Chancellor, Masters and Scholars of the University of Oxford",27,{"name":933,"count":934},"Danmarks Tekniske Universitet",24,{"name":936,"count":934},"Vib Vzw",{"name":938,"count":939},"Katholieke Universiteit Leuven",23,{"name":941,"count":939},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",{"name":943,"count":939},"Technische Universitaet Muenchen",{"name":945,"count":939},"Technische Universiteit Delft",{"name":947,"count":948},"The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undivided Trinity of Queen Elizabeth Near Dublin",22,{"name":950,"count":951},"Technische Universiteit Eindhoven",21,{"name":953,"count":951},"Universiteit Leiden",{"name":955,"count":956},"Eidgenoessische Technische Hochschule Zuerich",20,[958,960,962,964,966,968,970,972,974,976,978,980,982,984,986,988,989,992,994,997,1000,1003,1006,1008,1011],{"name":54,"count":959},299,{"name":12,"count":961},273,{"name":25,"count":963},261,{"name":163,"count":965},254,{"name":61,"count":967},221,{"name":48,"count":969},215,{"name":97,"count":971},191,{"name":265,"count":973},109,{"name":116,"count":975},85,{"name":198,"count":977},72,{"name":622,"count":979},62,{"name":134,"count":981},50,{"name":334,"count":983},48,{"name":91,"count":985},47,{"name":287,"count":987},40,{"name":181,"count":956},{"name":990,"count":991},"TR",19,{"name":390,"count":993},17,{"name":995,"count":996},"CY",12,{"name":998,"count":999},"CZ",11,{"name":1001,"count":1002},"LU",10,{"name":1004,"count":1005},"PL",8,{"name":1007,"count":1005},"SI",{"name":1009,"count":1010},"HU",5,{"name":103,"count":1012},2]