[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-proof-of-concept-2019":3,"awarded-stats-erc-proof-of-concept":885},{"awarded":4,"total":884},[5,16,21,27,33,39,46,51,56,63,69,74,78,83,88,92,97,102,107,113,119,124,130,136,141,148,154,160,166,171,177,182,186,191,196,201,207,213,218,223,228,233,238,243,249,254,259,265,270,275,280,284,291,295,299,303,308,312,316,320,325,330,337,341,347,352,357,362,368,374,379,385,389,394,399,404,409,415,420,425,430,436,441,446,452,457,461,465,470,474,479,484,488,494,499,505,510,516,522,526,531,535,539,543,548,552,557,561,566,570,574,578,582,586,591,596,600,604,608,612,616,620,625,631,636,641,647,652,657,663,667,672,676,681,686,691,695,699,704,709,713,718,723,728,732,737,741,746,751,756,760,765,769,774,779,785,790,795,801,805,810,814,819,824,829,834,840,845,850,854,859,863,868,872,876,880],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-862151","European Research Council","ERC Proof of Concept","Next Generation Imaging",null,"CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","FR",2019,"€150,000","Next generation sequencing has led to revolutionary discoveries in the fields of genetics, genomics, epigenetics and transcriptional regulation. The main limitation of this technology relies on the loss of spatial information: NGS is unable to retrieve the organization of nucleic acids (DNA\u002FRNA) in the cell or within the more complex structure of the tissue. We have recently developed a novel imaging-based technology, Hi-M, that enables the simultaneous detection of tens of DNA and RNA species i",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":11,"country":12,"year":13,"amount":19,"abstract":20},"cordis-european-research-council-award-839271","Industrialisation of curved sensors and related imagers","€149,850","Pillar II of the ERC-STG-ICARUS aimed at paving the way to a common use of curved sensors for cost-effective imaging systems, through prototyping and recommendation for mass production. The next steps towards commercialisation and industrialisation are proposed in this PoC project to: improve the repeatability, prepare the industrialisation, realise market studies and outline a business plan. We create the start-up CURVE-ONE for the valorisation towards scientific instrumentation and amateur ast",{"id":22,"funder":7,"programme":8,"title":23,"piName":10,"institution":24,"country":25,"year":13,"amount":14,"abstract":26},"cordis-european-research-council-award-862549","3D printed micro- and nano-optics for future integrated vision and endoscopy systems","UNIVERSITY OF STUTTGART","DE","Optics is abundant in today’s world. Smartphone cameras, optical sensors for autonomous driving, virtual and augmented reality, medical imaging technology, and many more areas all require tailored optical sensors. In most cases, the optical sensors are still based on classical optical systems. For instance, high-end cameras or high-quality endoscopes still utilize classical glass optics. The related markets have sizes of several tens of billion USD and grow with double digit rates.For all applic",{"id":28,"funder":7,"programme":8,"title":29,"piName":10,"institution":30,"country":12,"year":13,"amount":31,"abstract":32},"cordis-european-research-council-award-825492","Static Analysis for the VErification of Spreadsheets","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","€149,533","Spreadsheet applications (such as Microsoft Excel + VBA) are heavily used in a wide range of fields including engineering, finance, management, statistics and health. However, they do not ensure robustness properties, thus spreadsheet errors are hard to avoid, common and potentially very costly. According to estimates, the annual cost of spreadsheet errors is around 7 billion dollars. For instance, in 2013, a series of basic spreadsheet errors at JPMorgan incurred 6 billion dollars trading losse",{"id":34,"funder":7,"programme":8,"title":35,"piName":10,"institution":36,"country":37,"year":13,"amount":14,"abstract":38},"cordis-european-research-council-award-859927","Field Programmable Photonic Arrays","UNIVERSITAT POLITECNICA DE VALENCIA","ES","The core concept behind this POC proposal spins-off from the activity of the Advanced Grant ERC-ADG-2016-741415 UMWPCHIP. It will establish the innovation potential behind a novel and revolutionary concept, the Field Programmable Photonic Array (FPPA).The FPPA has a similar rationale as the FPGA in electronics: A common hardware is designed to provide several resources that can be employed to implement different functionalities by means of programming. However, the FPPA is different from the FPG",{"id":40,"funder":7,"programme":8,"title":41,"piName":10,"institution":42,"country":43,"year":13,"amount":44,"abstract":45},"cordis-european-research-council-award-812309","Development and commercialisation of a new purification system for contaminant-free radiocarbon dating","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","UK","€136,238","The ERC-funded project ‘PalaeoChron’ is exploring the dispersal and chronology of early anatomically modern humans outwards from Africa and into Eurasia between 60-40,000 years ago. The study of this key period, during which Neanderthals and other archaic humans disappeared to extinction, relies on the power of radiocarbon dating for the chronological framework underpinning it. There is a huge onus on reliable dating, but this is extremely challenging due to the overwhelming effects of even trac",{"id":47,"funder":7,"programme":8,"title":48,"piName":10,"institution":42,"country":43,"year":13,"amount":49,"abstract":50},"cordis-european-research-council-award-838081","FAIRWORK: Building a Fairwork Foundation","€149,776","Millions of platform workers live all over the world: doing work that is outsourced via platforms or apps in the ‘gig economy.’ Workers tend to have little ability to negotiate wages or working conditions with the platforms that give them work. The ERC GEONET project has shown that, as a result of this new market for work, many workers have jobs characterized by long and irregular hours, low income, and high stress. The international nature of digital work means that some of it can be done outsi",{"id":52,"funder":7,"programme":8,"title":53,"piName":10,"institution":42,"country":43,"year":13,"amount":54,"abstract":55},"cordis-european-research-council-award-838058","Integrating morpho-phonology in speech recognition","€149,919","Automatic Speech Recognition (ASR) is considered to represent the most natural man-machine interface across the spectrum of technological space. Current commercial ASR systems rely on a ‘rich’ representation of an acoustic signal for words and their variants, resulting in major challenges in the deployment of ASR systems in areas where it could have substantial social impact. Our central goal is to translate research results from the ERC funded project MORPHON into a novel ASR system to remove s",{"id":57,"funder":7,"programme":8,"title":58,"piName":10,"institution":59,"country":60,"year":13,"amount":61,"abstract":62},"cordis-european-research-council-award-842243","Portable EEG-based screening of social predispositions in newborns","UNIVERSITA DEGLI STUDI DI TRENTO","IT","€149,945","Predispositions to preferentially orient towards cues associated with social partners, such as face-like stimuli or biological and animate motion, appear to guide human social behavior from the onset of life and are typically impaired in children with autism-spectrum disorders (ASD). An early detector of social predispositions and their impairment in newborns might provide a valuable biomarker for ASD, an indicator of utmost relevance since infants with ASD greatly benefit from early behavioral ",{"id":64,"funder":7,"programme":8,"title":65,"piName":10,"institution":66,"country":37,"year":13,"amount":67,"abstract":68},"cordis-european-research-council-award-837874","Light Assisted-CRYStallization","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","€149,625","The objective of the LACRYS project is to validate and de-risk a technology based on light assisted crystallization for restoration of artworks (frescos), to assess its market potential and identify the most suitable exploitation strategy. Precipitation or dissolution oThe precipitation or dissolution of single and composite materials is a ubiquitous process in materials science and nature. So far, it can be controlled at large scale either in laboratory experiments or industrial processes. Howe",{"id":70,"funder":7,"programme":8,"title":71,"piName":10,"institution":72,"country":12,"year":13,"amount":14,"abstract":73},"cordis-european-research-council-award-862551","A Humanized Monoclonal Anti-Claudin1 Antibody (anti-CLDN1 mAb) for Treatment of Hepatocellular Carcinoma (HCC)","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","Hepatocellular carcinoma is the most frequent primary liver cancer and owing to its very aggressive nature is amongst the leading cause of cancer mortality worldwide (IARC). The number of liver cancer-related deaths in Europe in 2018 amounted to 77 375, and this number is expected to keep rising, reaching an estimated number of more than 100 000 deaths in 2040 (IARC). Major causes include the hepatitis B and C viruses, alcoholism, Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatit",{"id":75,"funder":7,"programme":8,"title":76,"piName":10,"institution":72,"country":12,"year":13,"amount":14,"abstract":77},"cordis-european-research-council-award-840415","Translating fundamental insights in podocyte metabolism and cell cycle regulation: development of a new treatment for Stopping crescentic Immune Glomerulonephritis","Rapidly progressive glomerulonephritis (RPGN) is a syndrome of the kidney that is characterized by a rapid loss of renal function, with severe damage of glomeruli, the filtering units of the kidney through glomerular crescent formation (crescentshaped scars) seen on kidney biopsies. If left untreated, it rapidly progresses into acute renal failure and death within months. Regardless of the underlying cause, RPGN involves severe injury to the kidneys' glomeruli, with many of the glomeruli contain",{"id":79,"funder":7,"programme":8,"title":80,"piName":10,"institution":81,"country":60,"year":13,"amount":14,"abstract":82},"cordis-european-research-council-award-862085","DISPLAY backliGHT illumination by femtosecond laser micromachining","CONSIGLIO NAZIONALE DELLE RICERCHE","Femtosecond laser micromachining is a powerful microfabrication technology for transparent materials. It allows direct writing of photonic circuit in the volume of glasses with arbitrary geometry and 3D layouts. In addition, the same tool can be used to selectively remove specific portions of the substrate, thus allowing complex and ultraprecise microstructuring of a piece of glass. In the ERC Advanced Grant CAPABLE, femtosecond laser micromachining is developed to unprecedented levels of contro",{"id":84,"funder":7,"programme":8,"title":85,"piName":10,"institution":86,"country":25,"year":13,"amount":14,"abstract":87},"cordis-european-research-council-award-862462","Simultaneous Localization and Mapping for Augmented Reality","TECHNISCHE UNIVERSITAET MUENCHEN","The PoC Project SLAM4AR is focused on developing technological foundations for advanced augmented reality (AR) applications on smartphones.  According to a recent study of Hampleton & Partners, the market value for AR applications is expected to break the $170 billion barrier by 2022.  And a significant share of this market value will come from smartphone applications.  In the PoC project SLAM4AR, we will build up on state-of-the-art algorithms for visual Simultaneous Localization and Mapping (S",{"id":89,"funder":7,"programme":8,"title":90,"piName":10,"institution":86,"country":25,"year":13,"amount":14,"abstract":91},"cordis-european-research-council-award-875594","A diagnostic device for personalized determination of vitamin B6 status and health","Vitamin B6 is an essential nutrient and part of a well-balanced diet. However, B6 deficiency is often observed in elderly people, diabetes patients and alcoholics and associated with higher rates of cardiovascular disease, stroke and cancer. All these risk populations need a stringent and continuous monitoring of B6 levels. At present B6 detection systems suffer from limited speed, scope, convenience and reliability. These tests require a medical doctor as well as external laboratories with expe",{"id":93,"funder":7,"programme":8,"title":94,"piName":10,"institution":86,"country":25,"year":13,"amount":95,"abstract":96},"cordis-european-research-council-award-838342","dataFlow: A Data-driven Fluid Flow Solving Platform","€149,500","With the recent breakthrough of deep learning methods, we currenty see the advent of employing this methodology in the context of physical simulations. Such simulations are widely used in numerous industrial fields, starting from car and airplane manufacturers, over computer graphics and animations to medical blood flow simulations.  The market for computer simulations is currently exceeding 15 billion USD world wide, with rising trends, and 3 billion spent in Europe alone.  A significant fracti",{"id":98,"funder":7,"programme":8,"title":99,"piName":10,"institution":100,"country":12,"year":13,"amount":14,"abstract":101},"cordis-european-research-council-award-875573","HighlY performing proton exchange membrane water electrolysers with reinforceD membRanes fOr efficient hydrogen GENeration","UNIVERSITE DE MONTPELLIER","The project SPINAM (ERC Starting Grant 2012 - FP7 Ideas Programme) introduced a new method of elaboration and assembly based on electrospinning to produce novel energy materials with improved properties. The project focused on the development of core materials (membrane-electrode assemblies, MEAs) of proton exchange membrane fuel cells (PEMFCs) and water electrolysers (PEMWEs). Water electrolysis is one promising opportunity to address the challenge of renewable energy storage, since the hydroge",{"id":103,"funder":7,"programme":8,"title":104,"piName":10,"institution":105,"country":43,"year":13,"amount":14,"abstract":106},"cordis-european-research-council-award-838672","Generation of ultra-deep libraries of transcriptional activators for gene therapy","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","We have generated a novel genetic circuit that, by combining an unusual site-specific recombinase and molecular splicing, allows to functionally diversify modular proteins in-vivo in a highly-directed manner. Applying this method to modular transcriptional activators allowed us to generate billions and even trillions of transcription factors variants in-vivo starting from a single base construct. The aim of the DIVERGE PoC project is to to explore the commercial potential of this approach for th",{"id":108,"funder":7,"programme":8,"title":109,"piName":10,"institution":110,"country":37,"year":13,"amount":111,"abstract":112},"cordis-european-research-council-award-825435","Development of Collagenase Polymeric nanocapsules as Therapeutics","UNIVERSIDAD COMPLUTENSE DE MADRID","€149,611","“Developments of Collagenase Polymeric nanocapsules as Therapeutics (DECOMPACT)”.  The goal of this proof of concept project is the development and commercialization of a novel treatment to scleroderma. Scleroderma is a fibrotic disease with a significant incidence in the population and is characterized by an abnormal accumulation of collagen. Treatment of this disease involves the use of proteolytic enzymes, as collagenase, able to digest collagen fibers. However, the labile nature of collagena",{"id":114,"funder":7,"programme":8,"title":115,"piName":10,"institution":116,"country":117,"year":13,"amount":14,"abstract":118},"cordis-european-research-council-award-825854","Table-top cathodoluminescence microscope","STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN","NL","We propose to develop a turnkey table-top cathodoluminescence (CL) microscope demonstrator that combines electron microscopy and optical spectroscopy to make optical images with a spatial resolution as small as 20 nm. The instrument design builds on expertise on CL microscopy that I have built up during my ERC Advanced research that has led to a highly successful and highly rewarded CL research program. The new microscope design is fully user-friendly, has a footprint of only 60×60 cm, enables h",{"id":120,"funder":7,"programme":8,"title":121,"piName":10,"institution":122,"country":60,"year":13,"amount":14,"abstract":123},"cordis-european-research-council-award-860365","COvariance Based RAman Spectrometer (COBRAS)","ELETTRA - SINCROTRONE TRIESTE SCPA","In COBRAS we will establish Femtosecond Covariance Spectroscopy, a new spectroscopic technique to measure the optical response of material which is based on stochastic light pulses characterized by frequency uncorrelated intensity fluctuation. By using light with different property every repetition, each reiteration of the experiment can be considered as a measurement under new conditions rather than a repetition of the same experiment. Crucially, within the ERC_StG project INCEPT we have demons",{"id":125,"funder":7,"programme":8,"title":126,"piName":10,"institution":127,"country":128,"year":13,"amount":14,"abstract":129},"cordis-european-research-council-award-862571","ADAMtx: Development of Alzheimer’s immunotherapy by harnessing the natural reparative properties of microglia","WEIZMANN INSTITUTE OF SCIENCE","IL","Alzheimer's disease (AD) is a heterogeneous disease in which multiple detrimental factors contribute to cognitive loss and disease escalation. Currently there are no effective therapies for AD.  Targeting any single symptom of disease-escalating factor (e.g. amyloid beta, tau, neuroinflammation etc.), even if successful, is not sufficient to modify the disease, as seen in the multiple failures of recent phase-III clinical trials. Thus, there is a desperate need for new approaches for development",{"id":131,"funder":7,"programme":8,"title":132,"piName":10,"institution":133,"country":134,"year":13,"amount":14,"abstract":135},"cordis-european-research-council-award-813021","Evaluation of Novel Ultra-Fast selective III-V Epitaxy","IBM RESEARCH GMBH","CH","As the worldwide photonics market is increasing and optical and electronic devices based on III-V semiconductors are gaining market segment, the production of III-V semiconductor wafers including GaN has increased in volume  and sizes have increased from 2” to 6”. However, this is still short of the 8”-12” common in Silicon CMOS technology. Furthermore, the integration of III-Vs on silicon or on-insulator, has been a long-standing goal for the past 50 years, in order to combine electronic and ph",{"id":137,"funder":7,"programme":8,"title":138,"piName":10,"institution":139,"country":128,"year":13,"amount":14,"abstract":140},"cordis-european-research-council-award-838359","Imaging flow cytometry using holographic virtual staining","TEL AVIV UNIVERSITY","Imaging flow cytometry (IFC) holds great promise as clinical screening and diagnostics platform, as it can capture, process and analyse a large number of cells in bodily fluids, useful for hematology and hemato-oncology. However, currently IFC captures cell morphology by imaging each fluorescently-stained cell organelle on a different region of the camera sensor, dictating complicated and expensive optics and processing units. Current IFC remains a highly inaccessible technology, due to its very",{"id":142,"funder":7,"programme":8,"title":143,"piName":10,"institution":144,"country":145,"year":13,"amount":146,"abstract":147},"cordis-european-research-council-award-825581","INCALO: Internal black carbon loading: validation of a novel biomarker","UNIVERSITEIT HASSELT","BE","€149,170","Ambient air pollution, including black carbon, entails a serious public health risk because of its carcinogenic potential and as climate pollutant. Inhalation of fossil fuel-derived particulate matter (PM) is associated with a wide range of non-pulmonary health effects. Based on the WHO report of 2015 the European health annual costs of air pollution have been estimated to US$ 1.6 trillion.   Although recent studies strongly suggest that particle translocation in biological systems is biological",{"id":149,"funder":7,"programme":8,"title":150,"piName":10,"institution":151,"country":117,"year":13,"amount":152,"abstract":153},"cordis-european-research-council-award-841865","Trial Ready Small Vessel MRI Markers: Proof of Concept","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","€149,979","Problem: Cerebral small vessel disease (SVD) is a hallmark of serious brain diseases such as acute stroke and dementia. It has a major impact on society, since it affects quality of life of many ageing individuals, and increasingly challenges the healthcare resources. Current image-based biomarkers do not reflect SVD itself, but rather macroscopic, irreversible brain damage, secondary to the abnormalities of the small vessels. This greatly hampers development of new drugs as clinical trials lack",{"id":155,"funder":7,"programme":8,"title":156,"piName":10,"institution":157,"country":158,"year":13,"amount":14,"abstract":159},"cordis-european-research-council-award-825142","Resistance-free charge spreading for LEDs and solar cells","AALTO KORKEAKOULUSAATIO SR","FI","Joule heating due to electrical resistance associated with current spreading in semiconductors is a significant loss mechanism in modern state-of-the-art high power light emitting diodes (LEDs) and high concentration solar cells. These losses can account for up to 10-30 % of the device power consumption under high power conditions, and thereby dramatically reduce the efficiency of solar energy harvesting and general lighting, whose efficiencies – apart from the resistive losses – are gradually c",{"id":161,"funder":7,"programme":8,"title":162,"piName":10,"institution":163,"country":37,"year":13,"amount":164,"abstract":165},"cordis-european-research-council-award-841063","Fluorescence-based nano-immunoassay IVD platform","ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE","€149,952","Antibody-detection related to disease or to drug monitoring demands novel IVD tests that provide robust, rapid and early- stage diagnostics for improved and early on-set treatments. However, companies developing novel IVD immunoassays face an important barrier related to reimbursement policy issues when the IVD tests are introduced into national health systems. This barrier discourages many companies from pursuing the development of novel diagnostic tests because the investment necessary to intr",{"id":167,"funder":7,"programme":8,"title":168,"piName":10,"institution":169,"country":43,"year":13,"amount":95,"abstract":170},"cordis-european-research-council-award-825122","3D Thin-Walled Ceramic and Ceramic-Metal Components using Electrolytic Plasma Processing","THE UNIVERSITY OF MANCHESTER","This proposal relates to the Proof of Concept stage investigation of exciting new findings in the ERC Advanced Grant ‘IMPUNEP’ project relating to the study and use of plasma-based processes. These findings offer significant advantages for the creation of complex 3D ceramic and ceramic-metal products at relatively low cost in an environmentally friendly manner. The potential applications of this new technology are very wide-ranging, and include the creation of new products as diverse as healthca",{"id":172,"funder":7,"programme":8,"title":173,"piName":10,"institution":174,"country":43,"year":13,"amount":175,"abstract":176},"cordis-european-research-council-award-824985","A new crop protection strategy by chemical priming of the plant immune system","THE UNIVERSITY OF SHEFFIELD","€148,318","A large proportion of global crop yield is annually lost to plant diseases. While pesticides help to reduce these losses, there are growing concerns about pesticide resistance and their impacts on health and environment. The objective of this proof-of-concept project is to develop a crop protection technology that is based on priming of the plant’s own immune system, providing an enhanced defensive capacity to resist attackers. While priming is considered attractive for exploitation in integrate",{"id":178,"funder":7,"programme":8,"title":179,"piName":10,"institution":180,"country":37,"year":13,"amount":14,"abstract":181},"cordis-european-research-council-award-862093","Hybrid Bead Adsorbents","FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA","Each year, millions of people, most of them children, die from diseases associated with inadequate water supply, sanitation and hygiene. In particular, exposure to heavy metals in drinking water, even at trace levels, poses a considerable health risk. As included in one of the seventeen sustainable development goals of the United Nations, “safe water and adequate sanitation are indispensable for healthy ecosystems, reducing poverty, and achieving inclusive growth, social well-being and sustainab",{"id":183,"funder":7,"programme":8,"title":184,"piName":10,"institution":127,"country":128,"year":13,"amount":14,"abstract":185},"cordis-european-research-council-award-835692","Comprehensive allergen detection using synthetic DNA libraries","Over the last 50 years, allergies have become a major health issue affecting approximately 20% of adults and more than 30% of children in developed countries. Allergies impair the life quality of affected individuals and diagnosis\u002Ftreatment is costly for health care systems. In the EU, the avoidable indirect costs of patients insufficiently treated for allergy is estimated to range between 55 and 151 billion Euro per year. A key issue towards fighting this allergy epidemic lies in the diagnosis ",{"id":187,"funder":7,"programme":8,"title":188,"piName":10,"institution":189,"country":25,"year":13,"amount":14,"abstract":190},"cordis-european-research-council-award-842452","Peripheral nerve Gel-based Orientation (Peripheral nerve injury recovery using Gel-based Orientation)","DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV","PeriGO will pave the way for the commercialization of a unique, first-of-its-kind peripheral nerve repair strategy, as it uses an injectable, biocompatible hydrogel that provides directionality through controlled guiding elements. The properties of the smart material Anisogel, initially developed in the ERC project ANISOGEL to repair spinal cord injuries, provide a sophisticated, superior alternative for peripheral nerve regeneration. The final product can be injected inside a bridging blood ves",{"id":192,"funder":7,"programme":8,"title":193,"piName":10,"institution":194,"country":43,"year":13,"amount":14,"abstract":195},"cordis-european-research-council-award-779921","Citizen Sense Air Monitoring Kit","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","In January 2013, the five-year ERC funded project Citizen Sense was launched, investigating the role of low-cost and digital monitoring technologies in facilitating and organising new types of environmental engagement. This proposal brings together a comprehensive citizen-sensing toolkit for users to undertake air quality monitoring that realises the social and environmental potential of these technologies. With the benefit of five years of intensive and cutting-edge research, the Citizen Sense ",{"id":197,"funder":7,"programme":8,"title":198,"piName":10,"institution":199,"country":117,"year":13,"amount":14,"abstract":200},"cordis-european-research-council-award-811285","Atlas","UNIVERSITEIT VAN AMSTERDAM","The human subcortex is a highly crowded brain area, which consists of hundreds of unique, small grey matter nuclei constituting approximately ¼ of total human brain volume. Importantly, only approximately 7% of these nuclei are currently accessible in standard human brain magnetic resonance imaging (MRI) atlases (Forstmann et al., 2016). This low percentage can have several imaging related causes, including the small size of subcortical nuclei as compared to the voxel size, which is particularly",{"id":202,"funder":7,"programme":8,"title":203,"piName":10,"institution":204,"country":205,"year":13,"amount":14,"abstract":206},"cordis-european-research-council-award-790575","PHILOS: Real-time Detection and Automated Mitigation of BGP Prefix Hijacking Attacks","IDRYMA TECHNOLOGIAS KAI EREVNAS","EL","The Internet, with its unprecedented success and global scale as a network of networks, depends heavily on few fundamental technologies. One of these technologies is the Border Gateway Protocol (BGP), which glues together the independent networks of the Internet. BGP, based on a three-decade old design, is highly susceptible to BGP prefix hijacking attacks. These attacks, which have been repeatedly covered in the news due to their critical impact in several prominent cases, persistently pest net",{"id":208,"funder":7,"programme":8,"title":209,"piName":10,"institution":210,"country":211,"year":13,"amount":14,"abstract":212},"cordis-european-research-council-award-862315","Verifying Authenticity with Liquid crystal-Derived Anti Theft Encoding","UNIVERSITE DU LUXEMBOURG","LU","Product counterfeiting, sometimes related to the theft of the original, has emerged as a significant economic issue, with the market value of pirated products equalling or exceeding the gross domestic product of some European countries. A 2016 report from OECD in cooperation with the EU Intellectual Property Office (EUIPO) found that in 2013 counterfeit products sold were worth €375 billion, totalling 2.5% of global trade. Counterfeit products range from high-end consumer luxury goods, to busine",{"id":214,"funder":7,"programme":8,"title":215,"piName":10,"institution":194,"country":43,"year":13,"amount":216,"abstract":217},"cordis-european-research-council-award-842251","Graphene-syncronized coherent Raman scattering laser and microscope","€149,628","The current standard of tumour diagnostics is histopathology, where excisions are taken from the tissue of a diseased patient, followed by staining and visual inspection. The process is time-consuming, costly, with low sensitivity and specificity. The results are subjective and qualitative, heavily depending on the judgement of the doctor. Spontaneous Raman microscopy is a label-free and non-invasive imaging technique, which enables to obtain objective and quantitative information on the tissue,",{"id":219,"funder":7,"programme":8,"title":220,"piName":10,"institution":221,"country":134,"year":13,"amount":14,"abstract":222},"cordis-european-research-council-award-875585","StiMuli-responsive reActoRs for waTer purification","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","Due to the many limitations of the conventional water treatment technologies, we are witnessing alarmingly high levels ofmicro-pollutants (MPs) such as antibiotics, pesticides, herbicides, estrogens, and pharmaceuticals, which enter our surfaceand groundwater ecosystems. In SMART project we propose to use novel catalytic membranes that have shown promisingresults in removing a variety of highly persistent organic compounds, with a removal efficiency of over 85%. Ourmembranes exhibit a unique abi",{"id":224,"funder":7,"programme":8,"title":225,"piName":10,"institution":226,"country":37,"year":13,"amount":67,"abstract":227},"cordis-european-research-council-award-825566","Bacterial chassis for treating ventilator-associated pneumonia (VAP)","FUNDACIO CENTRE DE REGULACIO GENOMICA","Among 65-80% of human infections are associated to biofilms, especially in respiratory infections or those associated with catheters. Endotracheal tube (ETT) biofilm is related to the development of ventilator-associated pneumonia (VAP), which occurs in 9–27% of all intubated patients. Those ETT-biofilms are mainly formed by Pseudomonas aeruginosa and\u002For Staphylococcus aureus, forming a protective barrier against antibiotics and the host immune system. The consequence of VAP is chronic inflammat",{"id":229,"funder":7,"programme":8,"title":230,"piName":10,"institution":231,"country":37,"year":13,"amount":14,"abstract":232},"cordis-european-research-council-award-825569","Developing a rapid diagnostic kit for antibiotic resistance","UNIVERSITAT AUTONOMA DE BARCELONA","Antimicrobial resistance (AMR) has become a worldwide epidemic, causing more than for 700.000 deaths per year globally, expected to rise to 10 million deaths annually, by 2050. AMR is associated with an increase in morbidity, longer hospitalization time and a marked increase in the associated medical costs. While several attempts are being enforced to reduce the misuse and abuse of antibiotics, we are in dire needs of methods to rationalize the use of antibiotics. Currently, bacterial cultures a",{"id":234,"funder":7,"programme":8,"title":235,"piName":10,"institution":236,"country":60,"year":13,"amount":14,"abstract":237},"cordis-european-research-council-award-875015","Pitot probe for non-ideal compressible flows of organic fluids for renewable energy applications","POLITECNICO DI MILANO","In a scenario of rising global energy needs, societal acceptance of renewable energy and yearning towards energy saving, the Organic Rankine Cycle (ORC) technology is playing a relevant role for a variety of renewable energy sources, from biomass to geothermal. ORC applications include also waste heat recovery from industrial processes, a segment with strong development potential. Due to the peculiarity of non-ideal flows in ORCs, measurements such as velocity, mass flow rate or turbine performa",{"id":239,"funder":7,"programme":8,"title":240,"piName":10,"institution":241,"country":43,"year":13,"amount":14,"abstract":242},"cordis-european-research-council-award-862541","Commercialisation of novel ultra-fast 3D laser scanning technology","UNIVERSITY COLLEGE LONDON","Understanding how the brain processes information is one of the unsolved grand   challenges in science. Moreover, neurological disorders, which disrupt information processing, have an enormous societal and economic impact. Studying information processing in the brain requires measurements of signals as they flow through neural circuits. However, the 3D nature of brain circuits and the speed of information transfer makes it difficult for neuroscientists to measure their properties with sufficient",{"id":244,"funder":7,"programme":8,"title":245,"piName":10,"institution":246,"country":25,"year":13,"amount":247,"abstract":248},"cordis-european-research-council-award-811385","Psychiatric Disorders: ATX-inhibiting drugs as a new therapeutic option: Proof-of-Concept","UNIVERSITAET MUENSTER","€149,375","Within the frame of the ERC LiPsyD we have shown that recently discovered that the phospholipid LPA acts as a synaptic modulator playing a major role in regulating cortical excitability and being involved in psychiatric disorders (Trimbuch et al., 2009; Unichenko et al., 2016; Vogt et al., 2016; Vogt et al., 2017). Using specific small molecule inhibitors like PF8380, which target the LPA-synthesizing molecule autotaxin (ATX), we were able to decrease cortical hyperexcitability and to rescue dis",{"id":250,"funder":7,"programme":8,"title":251,"piName":10,"institution":252,"country":25,"year":13,"amount":14,"abstract":253},"cordis-european-research-council-award-862535","A Programming Platform for Reactive Data-intensive Applications","TECHNISCHE UNIVERSITAT DARMSTADT","Ubiquitous connectivity of digital and physical worlds enabled by the convergence of edge (IoT, mobile), in-network and cloud computing plus algorithmic advances in artificial intelligence (AI) promise breakthroughs in next-generation Distributed Data-driven Reactive Applications (DRAs), which promise to radically innovate the economy and induce society-scale impact on production, mobility, energy, health, etc. But, such next-generation DRAs are not only expensive and difficult to develop, deplo",{"id":255,"funder":7,"programme":8,"title":256,"piName":10,"institution":257,"country":37,"year":13,"amount":14,"abstract":258},"cordis-european-research-council-award-812850","2shRNA branched nanobinders as promising therapeutic tools for combined cancer therapy","FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)","This project aims to optimize and validate a promising therapeutic tool for combined cancer therapy, 2shRNA, in an ex vivo model system.Combined therapies are of great significance nowadays, due to their key role in fighting, for instances, resistance processes during cancer treatment. Nonetheless, the drug combinations approved to date face several problems, such as cooperative toxicity effects, lack of efficiency and poor bioavailability. We have designed and synthesized 2shRNA, a new bifuncti",{"id":260,"funder":7,"programme":8,"title":261,"piName":10,"institution":262,"country":263,"year":13,"amount":14,"abstract":264},"cordis-european-research-council-award-838414","Identification of nano-mechanical fingerprints as a biomarker for cancer treatment prognosis","UNIVERSITY OF CYPRUS","CY","In the fight against cancer, it is well recognized that tumors are highly heterogeneous and they might differ considerably not only between tumors types but also among tumors of the same type or even for the same tumor during progression. As a result, the efficacy of standard cancer chemotherapies varies, and while some patients respond to a particular treatment, other patients do not gain any benefit and in many cases, the condition of the patient deteriorates due to adverse effects. Consequent",{"id":266,"funder":7,"programme":8,"title":267,"piName":10,"institution":226,"country":37,"year":13,"amount":268,"abstract":269},"cordis-european-research-council-award-825176","Improved Patient Care by Combinatorial Treatment","€145,000","Targeted precision medicine combined with companion diagnostics will provide the basis for future more effective more economic patient care. Recent advances in breast cancer treatment combining inhibitors of poly-ADP-ribose polymerase (PARP1) in conjunction with other targets are at the forefront of this new advance both at the level of basic research and pharmaceutical interest, due to its pivotal role in gene expression, chromatin and repair.  We have discovered a key enzyme downstream of PARP",{"id":271,"funder":7,"programme":8,"title":272,"piName":10,"institution":273,"country":134,"year":13,"amount":14,"abstract":274},"cordis-european-research-council-award-840636","Development of small molecule inhibitors of circulating tumor cell clusters","UNIVERSITAT BASEL","Despite the great progress that has been made in treating cancer, metastasis remains incurable. Metastasis accounts for 8 million deaths per year worldwide and no agents are currently available to prevent the metastatic spread of cancer. The metastatic process begins with cancer cells leaving the primary tumor site and entering the blood circulation. In circulation, cancer cells are defined as circulating tumor cells (CTCs), and are typically found in the form of single CTCs or small CTC aggrega",{"id":276,"funder":7,"programme":8,"title":277,"piName":10,"institution":278,"country":117,"year":13,"amount":14,"abstract":279},"cordis-european-research-council-award-841109","Designing Devices by Doping on Demand","TECHNISCHE UNIVERSITEIT DELFT","Electronic doping, the control over the charge carrier density, is at the heart of the success of the semiconductor industry. Promising new semiconductor materials like conductive polymers, fullerenes and quantum dots cannot be doped by traditional doping methods. The applicant and his group have developed a general method to dope these materials on demand with an electrochemical method, combined with photopolymerization of the solvents and electrolyte ions.    This methods allows to precisely c",{"id":281,"funder":7,"programme":8,"title":282,"piName":10,"institution":278,"country":117,"year":13,"amount":14,"abstract":283},"cordis-european-research-council-award-875164","Efficient hydrogen sensing with atomically engineered materials","Hydrogen will be a key element of our future decarbonised economy as a sustainable energy vector. In the future economy, efficient hydrogen sensors will be a critical element. The high flammability of air-hydrogen mixtures and the minimal input power required to trigger combustion pose serious safety concerns. The light nature of the hydrogen molecule and its high diffusivity makes detection and leakage-control particularly challenging. Leak detection in a distribution network requires the avail",{"id":285,"funder":7,"programme":8,"title":286,"piName":10,"institution":287,"country":288,"year":13,"amount":289,"abstract":290},"cordis-european-research-council-award-825905","Mechano-activated Extracellular Vesicle Based Repair of Bone","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","IE","€149,891","Every 30 seconds a person suffers an osteoporosis-related bone fracture in Europe, resulting in significant morbidity, mortality and healthcare costs estimated at €36billion annually. Current anti-catabolic therapeutics are associated with severe side effects and are purely preventative, while the only anabolic treatment plateaus at 6 months. This has resulted in a crisis in osteoporosis treatment. Therefore, the aim of EVERBONE is to develop and commercialise a new anabolic multitargeted medici",{"id":292,"funder":7,"programme":8,"title":293,"piName":10,"institution":287,"country":288,"year":13,"amount":14,"abstract":294},"cordis-european-research-council-award-861673","Ink-jet printed energy storage devices on textiles: powering the next generation of smart clothing","The aim of this proposal is to determine the economic and technical feasibility of using readily scalable technologies for thedevelopment of inexpensive and high-performance ink-jet printed, energy storage devices based on two- dimensionalnanosheets for smart wearables and textile-electronics. The realization of gesture control through e-textiles requires highlyintegrated sensors, which sets higher requirements for the formation of electrode patterns and power supply. In all thesecases, a power ",{"id":296,"funder":7,"programme":8,"title":297,"piName":10,"institution":287,"country":288,"year":13,"amount":14,"abstract":298},"cordis-european-research-council-award-875512","Advanced Atmospheric Carbon Capture Technology","Ever increasing atmospheric CO2 concentrations and global emissions of 36 Gt\u002Fyear impose unprecedented threats to the world’s ecosystem and endanger industrial human activities in their entirety. This AACCT project will establish a new advanced technology that facilitates efficient CO2 capture from air and results in a commercial, stand-alone prototype that will demonstrate its economical and ecological viability, outperforming all other emerging approaches to atmospheric CO2 capture. The techno",{"id":300,"funder":7,"programme":8,"title":301,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":302},"cordis-european-research-council-award-825404","Launching high-resolution relaxometry - A powerful new analytical tool for industry","Analytical methods are essential in many industries, such as chemistry, energy, pharmaceutical, and in health services. These methods usually fall into one of two categories: they either identify molecules and their structures or determine the properties of a fluid or a solid. This project will introduce a game-changing method to industry: high-resolution relaxometry in NMR, a label-free method, which combines both approaches as it identifies molecules and characterizes their individual properti",{"id":304,"funder":7,"programme":8,"title":305,"piName":10,"institution":11,"country":12,"year":13,"amount":306,"abstract":307},"cordis-european-research-council-award-824735","Automated evaluation and correction of generation bias in immune receptor repertoires","€149,906","Personalized medicine is promising to change the health and prophylactics sectors, already showing large societal and economic impact. High throughput immune sequencing technologies give us insight into a unique personal medical record - our immune system’s memory of all encountered infections and the successful solutions our body found. Unfortunately, reading this record requires advanced statistical tools making it often inaccessible to biologists and medical practitioners. PGEN offers a solut",{"id":309,"funder":7,"programme":8,"title":310,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":311},"cordis-european-research-council-award-862471","Quantum technology with carbon nanotUBEs","The goal of the “Quantum technology with carbon nanotUBEs”, QUBE, project is to provide a commercial solution enablingan easy manipulation of single wall carbon nanotubes, structurally characterized for quantum technologies. This solution will be fully adapted for being integrated into quantum devices. The project will aim to rationalize the production of high quality, “ready to use”, single wall carbon nanotubes and to create of a start-up company whithin the emerging quantum industry sector in",{"id":313,"funder":7,"programme":8,"title":314,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":315},"cordis-european-research-council-award-874986","metasurface-Integrated Light Detection and Ranging","The “i-LiDAR” PoC project addresses the realisation of high-resolution and high-frame rate imaging systems. Relying on a combination of newly developed planar optical components, known as metasurfaces to achieve large deflection angles, with existing opto-mechanical systems, known for their high-speed light modulations, we will realize new light detection and ranging devices. The proof of concept devices are of great interests for both civil and military applications. Improving the scanning rate",{"id":317,"funder":7,"programme":8,"title":318,"piName":10,"institution":105,"country":43,"year":13,"amount":14,"abstract":319},"cordis-european-research-council-award-874581","Development of GPER agonists as a novel therapeutic option for pancreatic cancer","Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is the fourth-leading cause of cancer related mortality and is predicted to be the second leading cause of cancer death by 2030. Widely regarded as a death sentence, the 5-year survival rate is less than 5% and this figure has not changed over the past four decades due to lack of effective therapies. PDAC develops in a fibrotic setting that hampers drug delivery and modulates immune response & tumour growth\u002Fdisse",{"id":321,"funder":7,"programme":8,"title":322,"piName":10,"institution":105,"country":43,"year":13,"amount":323,"abstract":324},"cordis-european-research-council-award-825813","Metabolic Profiling of the Vaginal Microbiome for Reproductive Health","€149,633","There is ever increasing evidence that the vaginal microbiome plays an important role in reproductive health. Studies have shown that dysbiotic states can culminate in bacterial vaginosis, urinary tract infections and premature birth. Although the microbiome is usually characterised by 16S rRNA sequencing, the methodology is time consuming and expensive. Here we describe the development of a desorption ionisation mass spectrometry (DESI-MS) based technique which characterises microbial community",{"id":326,"funder":7,"programme":8,"title":327,"piName":10,"institution":328,"country":117,"year":13,"amount":14,"abstract":329},"cordis-european-research-council-award-862283","Greenhouse gases to valuable liquid chemicals:  High-flux zeolite membrane-based reactor for the efficient conversion of CH4 and CO2","UNIVERSITEIT UTRECHT","Both methane (CH4) and carbon dioxide (CO2) are greenhouse gases, but are available in large supply, and are often flared or vented. A promising strategy to efficiently utilize these abundant molecules is their transformation to easily transported liquid chemicals, which is particularly attractive because this conversion not only reduces emissions of the greenhouse gases into the atmosphere, but also produces commodity chemicals that can be either used as fuels or as precursors for many industri",{"id":331,"funder":7,"programme":8,"title":332,"piName":10,"institution":333,"country":334,"year":13,"amount":335,"abstract":336},"cordis-european-research-council-award-841775","Automatized Design of Injection Molds","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","AT","€149,829","The goal of this project is to develop the proof of concept for a novel injection-molding design workflow, making mold design accessible to a new, semi-professional user base of designers, engineers, and artists. It will provide a more more cost-efficient way of bringing lower-volume and customized products to the market. Recently, the related Materializable ERC Starting Grant has lead to the invention of novel computational tools for mold design, where the decomposition of a general 3D shape in",{"id":338,"funder":7,"programme":8,"title":339,"piName":10,"institution":133,"country":134,"year":13,"amount":14,"abstract":340},"cordis-european-research-council-award-825794","Brownian Motor Based Virus Detection","The detection of dilute populations of nanoparticles in microfluidics is difficult due to diffusion as the time limiting step to reach the sensor. Using active transport, we propose to build a proof of concept microfluidic device that reaches sub-attomolar detection sensitivity within an hour and at a device footprint of 1 cm. The active transport enables size separation of the particles into multiple channels and up-concentration in detection reservoirs for label free detection. At the end of t",{"id":342,"funder":7,"programme":8,"title":343,"piName":10,"institution":344,"country":145,"year":13,"amount":345,"abstract":346},"cordis-european-research-council-award-842501","Implementation of ACT in Daily Life","KATHOLIEKE UNIVERSITEIT LEUVEN","€149,688","Mental health problems constitute a major individual, family and public health concern, affecting up to 30% of the population. Yet, both pharmacological and psychological interventions only reach modest effect sizes. There is a need for new and better personalised interventions. In my ERC 'INTERACT' project, we adopted a mobile Health (mHealth) approach for the treatment of psychotic disorder. We developed ACT-DL (Acceptance and Commitment in Daily Life), an app that complement face-to-face ACT ",{"id":348,"funder":7,"programme":8,"title":349,"piName":10,"institution":350,"country":60,"year":13,"amount":10,"abstract":351},"cordis-european-research-council-award-841640","On demand design of reversible shape changing metamaterials","UNIVERSITA DEGLI STUDI DI MILANO","We propose to commercialize a software for the automatic design of responsive metamaterials structures for additive manufacturing. During the course of the ERC AdG SIZEFFECTS project, the PI studied the effect of disorder on the mechanics of materials using discrete elements models (DEM), allowing for an efficient simulation of large disordered structures, including metamaterials. The METADESIGN project exploits DEM methodologies and optimization algorithms developed throughout the SIZEFFECTS pr",{"id":353,"funder":7,"programme":8,"title":354,"piName":10,"institution":355,"country":25,"year":13,"amount":14,"abstract":356},"cordis-european-research-council-award-812943","Strain-stiffening polymer structures for orthotics","CHRISTIAN-ALBRECHTS-UNIVERSITAET  ZU KIEL","A strain-stiffening material is a material that increases its stiffness in response to deformation. This behaviour is frequently found in nature to protect systems from destruction. For example, in cells strain-stiffening occurs by the cross-linking of cytoskeletal fibers upon external forces. Within the ERC project CELLINSPIRED we have developed a material where we mimic this biological behavior in a novel type of artificial strain-stiffening material, where comb-like structures touch each othe",{"id":358,"funder":7,"programme":8,"title":359,"piName":10,"institution":360,"country":43,"year":13,"amount":14,"abstract":361},"cordis-european-research-council-award-838787","Music-assisted programmes: Developing communication in autism spectrum disorder through music making","THE UNIVERSITY OF READING","Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterised by atypical social communication and interaction, and repetitive and restricted behaviours, activities and interests, affecting around 1% of the general population worldwide. It is estimated that about 30% of children with ASD do not develop functional speech, and remain non-verbal or minimally verbal even after years of speech, language and educational interventions. Although a wide range of programmes have been devel",{"id":363,"funder":7,"programme":8,"title":364,"piName":10,"institution":365,"country":25,"year":13,"amount":366,"abstract":367},"cordis-european-research-council-award-838894","Cavity-enhanced optical microscope","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€149,875","Visualization of material objects is instrumental for our perception and understanding of nature. Nanoscale matter, however, escapes direct visualization by optical imaging due to weak interaction with light. Thus, studies of nanoparticles and molecules with common light absorption or emission microscopes are predominantly limited to macroscopic samples. Our recent developments of cavity-enhanced light-matter coupling provide means to boost the sensitivity of optical microscopy to the level of s",{"id":369,"funder":7,"programme":8,"title":370,"piName":10,"institution":371,"country":25,"year":13,"amount":372,"abstract":373},"cordis-european-research-council-award-842613","Innovative adhesives for ear drum healing","INM - LEIBNIZ-INSTITUT FUER NEUE MATERIALIEN GEMEINNUETZIGE GMBH","€149,000","The ERC ADG “Engineering of biomimetic surfaces – Switchable micropatterns for controlled adhesion and touch” (SWITCH2STICK) has developed micropatterned polymer surfaces for innovative adhesive functions without glues, based on the “gecko adhesion principle”. While robotic applications were originally in the focus of these developments, a radically new application field of these microstructures will be taken to the initial steps of application and subsequent commercialization: the repair of inj",{"id":375,"funder":7,"programme":8,"title":376,"piName":10,"institution":377,"country":37,"year":13,"amount":14,"abstract":378},"cordis-european-research-council-award-835857","NEW METHOD TO ACTIVATE STREPTOMYCES SECONDARY METABOLISM CRYPTIC PATHWAYS","UNIVERSIDAD DE OVIEDO","The aim of the StrepCrypPath is to test the industrial potential of a new approach to enhance Streptomyces secondary metabolism, discovered in our ERC-StG Strp-differentiation (280304) project. We discovered a pleiotropic regulator of differentiation and secondary metabolism in the S. coelicolor model strain. The S. coelicolor strain lacking this regulator is the first Streptomyces reported to produce secondary metabolites during its whole developmental cycle, including germination, the exponent",{"id":380,"funder":7,"programme":8,"title":381,"piName":10,"institution":382,"country":37,"year":13,"amount":383,"abstract":384},"cordis-european-research-council-award-790469","Natural Hands for Intuitive Virtual 3D Interaction","UNIVERSIDAD REY JUAN CARLOS","€149,701","Human-computer interaction (HCI) and Virtual reality (VR) are two fields that are succeeding to break from the research setting into the market. The CLAP project follows this trend and will introduce practical advances into both HCI and VR. In a nutshell, it will enable users to interact with digital content directly with their hands.CLAP is sustained on recent research carried out in the ERC Starting Grant 'Animetrics', which enables interactive simulation of natural hands. Thanks to the result",{"id":386,"funder":7,"programme":8,"title":387,"piName":10,"institution":241,"country":43,"year":13,"amount":14,"abstract":388},"cordis-european-research-council-award-862216","A Fast Throughput Drosophila Model to Identify Drug Treatments for Age-related Hearing Loss (ARHL)","SHORT SUMMARY ABSTRACT  (2,000 characters max.)The widespread increase in Hearing Loss is one of the major threats to future well-being in ageing human societies. The World Health Organisation (WHO) expects that by 2050 more than 900 million people will suffer from disabling hearing loss (i.e. a hearing loss >40dB in the better hearing ear for adults and >30 dB for children, respectively). The corresponding global cost is estimated to be more than US$ 1 trillion per year. The associated societal",{"id":390,"funder":7,"programme":8,"title":391,"piName":10,"institution":392,"country":60,"year":13,"amount":14,"abstract":393},"cordis-european-research-council-award-875523","Autonomous Prostate Biopsy","UNIVERSITA DEGLI STUDI DI VERONA","The PROST PoC proposal aims at demonstrating the technical, clinical and economical feasibility of autonomous prostate biopsy execution, by applying the technologies developed by the ERC project ARS (Autonomous Robotic Surgery) to a robotic prostate biopsy system. Prostate biopsy is a good candidate for the application of automation in clinical practice since it is a rather simple procedure, carried out on more than 1 Mil\u002Fyear patients in Europe, and still affected by a diagnostic error higher t",{"id":395,"funder":7,"programme":8,"title":396,"piName":10,"institution":397,"country":60,"year":13,"amount":14,"abstract":398},"cordis-european-research-council-award-825942","a rapid and efficient method for generation of iPSC","FONDAZIONE TELETHON ETS","The discovery of induced pluripotent stem cells (iPSC) has provided a major advance in biomedical research as they are able to offer meaningful models to investigate human diseases and biology. A growing number of research laboratory are using iPSC for studying a wide variety of human diseases. iPSC have also tremendous potential for regenerative medicine because they can be virtually differentiated in any type of cell. Through the support of the ERC grant IEMTx, we built-up an in-house protocol",{"id":400,"funder":7,"programme":8,"title":401,"piName":10,"institution":402,"country":60,"year":13,"amount":14,"abstract":403},"cordis-european-research-council-award-840331","tPA-Nanoconstructs for Treating Acute Ischemic Stroke: a Technical and Commercial Analysis","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","Acute ischemic strokes result from the occlusion of cerebral vessels by blood clots causing neurological complications, brain damage and death. Based on WHO reports, stroke affects 17M people per year worldwide, with 6M deaths and 5M survivors suffering long-lasting disabilities. Recent statistics estimate an EU direct healthcare cost for stroke of €20B and indirect costs, due to disabilities and lost productivity, of €25B. The two current treatments – thrombolysis and thrombectomy – come with l",{"id":405,"funder":7,"programme":8,"title":406,"piName":10,"institution":407,"country":60,"year":13,"amount":14,"abstract":408},"cordis-european-research-council-award-842423","Microfluidic chambers for establishing physiological and pathological human iPSC-derived neuronal circuits","OSPEDALE SAN RAFFAELE SRL","In vitro cultures of brain cells generate an ease and accessible ensemble of neurons In vitro cultures of brain cells generate an ease and accessible ensemble of neurons which has been invaluable for innumerable cellular and molecular studies. However, brain tissue dissociation and neuronal plating in vitro causes a complete loss of the original connections present into the brain tissue. Therefore, in vitro neuronal cultures do not allow to model specific neuronal circuits and study their specif",{"id":410,"funder":7,"programme":8,"title":411,"piName":10,"institution":412,"country":413,"year":13,"amount":14,"abstract":414},"cordis-european-research-council-award-825018","Cellulose Aluminium Polymer multi-ions composite Solid-electrolyte","NOVA ID FCT - ASSOCIACAO PARA A INOVACAO E DESENVOLVIMENTO DA FCT","PT","A low cost and efficient cellulose aluminium polymer multi-ions solid electrolyte (CAPSEL), with ionic conductivity in the range of 1-3 mS\u002Fcm, has been produced by a simple process which enables thin and large area battery production. An electrolyte with inherent potential towards Al based batteries and posterior commercialisation. CAPSEL may represent a good alternative to Li based batteries as Al is an abundant, cheaper and less reactive metal compared to Li. The formulation of CAPSEL can be e",{"id":416,"funder":7,"programme":8,"title":417,"piName":10,"institution":418,"country":37,"year":13,"amount":14,"abstract":419},"cordis-european-research-council-award-840052","Cognitive Rehabilitation Gamming System (cRGS): a novel Virtual Reality-based system for the conjunctive training of stroke-derived cognitive impairments","FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA","The cDAC ERC Advanced project develops and validates a theory of consciousness and its application to the understanding and alleviation of its deficits. cDAC proposes that consciousness is a virtualization memory system that monitors and optimizes the real-time control of perception, cognition and action realized in a multi-layered architecture. Building on cDAC, we have advanced and validated new concepts and methods for the diagnostics and treatment of cognitive and affective deficits post-str",{"id":421,"funder":7,"programme":8,"title":422,"piName":10,"institution":423,"country":60,"year":13,"amount":14,"abstract":424},"cordis-european-research-council-award-813223","Moving a novel gene therapy paradigm to treat  blindness to the market","UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II","At present therapies for inherited dominant disorders are not available, thus representing an urgent unmet medical and social need. The ERC Grant ALLELECHOKER enabled the PI to discover three modes to generate transcriptional repression by transcription factors (TFs) based on Zinc-finger scaffold: i- synthetic transcription factor (TF; Mussolino et al., EMBO Mol. Med. 2011 Mar;3(3):118-28; Botta S. et al. Elife. 2016 Mar 14;5), ii- synthetic DNA-binding protein (Botta S. et al. Elife. 2016 Mar 1",{"id":426,"funder":7,"programme":8,"title":427,"piName":10,"institution":428,"country":158,"year":13,"amount":14,"abstract":429},"cordis-european-research-council-award-861947","PEPTICHIP: Streamlined identification of tumour neoantigens for personalised anti-cancer immunotherapy","HELSINGIN YLIOPISTO","Immunotherapeutic strategies have emerged as powerful tools to treat many types of cancers. However, the majority of patients still fails to respond to immunotherapies as targetable tumour characteristics vary from patient to patient. Thus, a greater degree of personalisation is required to fine-tune immunotherapies to the specific vulnerabilities of each patient’s tumour. While therapies that target tumour-specific antigens (neoantigens) invoke a strong and specific anti-tumour immune response,",{"id":431,"funder":7,"programme":8,"title":432,"piName":10,"institution":433,"country":25,"year":13,"amount":434,"abstract":435},"cordis-european-research-council-award-832409","Translating the Global Refined Analysis of Newly transcribed RNA and Decay rates by SLAM-seq","JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG","€149,564","I propose to introduce novel analysis tools via a platform for three recently developed RNA sequencing (RNA-seq) mI propose to introduce novel analysis tools via a platform for three recently developed RNA sequencing (RNA-seq) methods (SLAM-seq, TimeLapse-seq and TUC-seq). All three methods enable the direct detection of new RNA transcribed by cells in a defined window of time within the pool of total cellular RNA. This is achieved by the introduction and subsequent detection of base-mismatches ",{"id":437,"funder":7,"programme":8,"title":438,"piName":10,"institution":439,"country":334,"year":13,"amount":14,"abstract":440},"cordis-european-research-council-award-875518","Nanoelectromechanical Infrared Detector","TECHNISCHE UNIVERSITAET WIEN","The aim of this proposal is to develop an uncooled nanoelectromechanical detector for infrared (IR) and terahertz (THz) radiation, which surpasses the sensitivity of state-of-the-art uncooled detectors by up to two orders of magnitude. The reliable and quantitative sensing of light is a fundamental task ubiquitous to modern technology. The IR to THz region of the electromagnetic spectrum hosts a wealth of intriguing interactions between radiation and matter, which are of particular interest for ",{"id":442,"funder":7,"programme":8,"title":443,"piName":10,"institution":444,"country":117,"year":13,"amount":14,"abstract":445},"cordis-european-research-council-award-862537","Structure guided inhibition of IDOL to treat atherosclerosis and the metabolic syndrome","ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM","The prevalence of the MetS and associated co-morbidities including cardiovascular disease has reached epidemic proportions in the developed and developing world. The cost of treating these conditions represents a substantial part of current European healthcare expenditure, and  despite recent advances, treatments for MetS-associated lipid disorders are far from optimal; mainstay lipid-lowering treatments (e.g. statins) reduce cardiovascular risk by only ~30%, and recently-introduced PCSK9 inhibi",{"id":447,"funder":7,"programme":8,"title":448,"piName":10,"institution":449,"country":288,"year":13,"amount":450,"abstract":451},"cordis-european-research-council-award-788152","DRAIOCHT- A low-cost minimally invasive platform medical device for the treatment of disorders of the cardiovascular system.","UNIVERSITY OF GALWAY","€130,310","Microwave ablation produces a small and highly controllable heating zone, ideal for the thermal treatment of a range of medical conditions where damage to adjacent structures is a significant risk.Potential applications range from the treatment of small soft-tissue cancers to the management of various venous disorders. The DRAIOCHT project will involve the design, development and pre-clinical evaluation of a novel microwave ablation device for the treatment of disorders of the venous system. The",{"id":453,"funder":7,"programme":8,"title":454,"piName":10,"institution":455,"country":128,"year":13,"amount":14,"abstract":456},"cordis-european-research-council-award-862040","Learning efficient millimeter wave radar imaging for autonomous vehicles","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","The emerging autonomous vehicle ecosystem is expected to grow with an almost 40% CAGR in the next decade hitting €485 billion by 2026 and exceeding €6 trillion in 2050. There is wide industry consensus that improved long-range depth sensing modalities are imperative for the viability of self-driving cars. State-of-the-art optical technologies are still prohibitively expensive, have insufficient temporal and spatial resolution, do not provide an accurate velocity reading, and are restricted to a ",{"id":458,"funder":7,"programme":8,"title":459,"piName":10,"institution":127,"country":128,"year":13,"amount":14,"abstract":460},"cordis-european-research-council-award-836086","Selective 20S proteasome inhibition for multiple myeloma therapy","Multiple myeloma (MM) is a cancer of plasma cells, that is incurable, and the second most common form of blood cancer. Proteasome inhibitors (PIs) are considered a mainstay in the treatment of MM and mantle cell lymphoma (MCL). Current drugs, based on PIs however, target the chymotrypsin-like activity of the 20S proteasome, and inhibit the activities of both the 20S and 26S proteasomes. Thus, it is possible that selective drug intervention specifically inhibiting only the 20S proteasomes will re",{"id":462,"funder":7,"programme":8,"title":463,"piName":10,"institution":455,"country":128,"year":13,"amount":14,"abstract":464},"cordis-european-research-council-award-825117","Photoelectrochemical Hydrogen Production from H2S in a Regenerative Scrubber","Commercialization of photoelectrochemical cells for solar hydrogen production from water is challenging due to the competitive low cost of hydrogen derived from natural gas. Renewable (solar-derived) hydrogen from alternative sources with more favorable economics is therefore being explored. Currently, caustic scrubbers for H2S abatement from sour gas and wastewater produce NaHS, a hazardous commodity chemical that is produced in the Kraft process, to produce wood pulp from wood for the producti",{"id":466,"funder":7,"programme":8,"title":467,"piName":10,"institution":468,"country":117,"year":13,"amount":14,"abstract":469},"cordis-european-research-council-award-838321","Validation of Innovative Lipopeptide Antibiotics","UNIVERSITEIT LEIDEN","Antibiotic resistance presents a growing threat to global health. The emergence of the superbugs is alarming: at current rates of increase, and without new intervention strategies, antibiotic resistance could cause a staggering 10 million deaths\u002Fyear worldwide by 2050. Therefore, new approaches need to be developed to combat antibiotic resistance, particularly for the WHO’s priority pathogens which include the so-called ESKAPE family of dangerous drug-resistant bacteria.Recently, we developed a ",{"id":471,"funder":7,"programme":8,"title":472,"piName":10,"institution":127,"country":128,"year":13,"amount":14,"abstract":473},"cordis-european-research-council-award-875328","New Target and Drug Candidates for Alleviating Chronic Pain","Chronic pain is one of the most significant unmet medical needs and health burdens in society today. This is due to limited analgesic efficacy of existing drugs, coupled with adverse side effects, and the development of tolerance over time. Moreover, patients may develop dependence on commonly prescribed opiate-based analgesics, with negative consequences and greatly increased societal costs. Hence there is a pressing need for new targets for drug development and new drug candidates to target ch",{"id":475,"funder":7,"programme":8,"title":476,"piName":10,"institution":477,"country":117,"year":13,"amount":14,"abstract":478},"cordis-european-research-council-award-862032","Nanoextraction, separation and detection of micropollutants in one single and simple step","UNIVERSITEIT TWENTE","Sample preparation is considered to be the most difficult step in analytic workflow. Current methods for extraction andseparation of minute substances in liquid samples are laborious, time-consuming, often involve large amounts of toxicorganic solvents, and are often difficult to automatize, implying high costs of man-power. An innovative sample preparationtechnique which has the potential to overcome these shortcomings will be developed in this project. Based on the firstpromising results in th",{"id":480,"funder":7,"programme":8,"title":481,"piName":10,"institution":482,"country":43,"year":13,"amount":14,"abstract":483},"cordis-european-research-council-award-841827","Self-Emulsification Route to NanoEmulsions by Cooling of Industrially Relevant Compounds","QUEEN MARY UNIVERSITY OF LONDON","Industrial emulsification often requires inefficient, high energy processes, such as mechanical shear leading to high temperatures in emulsificaiton. Our new efficient method has enabled self-emulsificatino at low temperatures by simply cooling an emulsion. We will apply this method to industrially relevant compounds for the food and pharma industries.",{"id":485,"funder":7,"programme":8,"title":486,"piName":10,"institution":439,"country":334,"year":13,"amount":14,"abstract":487},"cordis-european-research-council-award-842066","Symbol Elimination in Reliable System Engineering","We are living in a world that is increasingly run by software. Daily activities, such as online banking, mobile communications and air traffic use, are controlled by software. This software is growing in size and functionality, but its reliability is hardly improving. We are getting used to the fact that that computer systems are error-prone and insecure. To (re)gain the trust of end-users in software and Web services, formal automated reasoning is one of the main investments made by ICT compani",{"id":489,"funder":7,"programme":8,"title":490,"piName":10,"institution":491,"country":25,"year":13,"amount":492,"abstract":493},"cordis-european-research-council-award-825968","Silicon-Integrated Graphene Photodetectors for Future Photonic Integrated Circuits – Graph-IC","GESELLSCHAFT FUR ANGEWANDTE MIKRO UND OPTOELEKTRONIK MIT BESCHRANKTERHAFTUNG AMO GMBH","€149,750","The goal of the Graph-IC proof of concept proposal is to verify the innovation potential of silicon-technology-integrated graphene photodetectors for high-speed and broadband light conversion. The idea of this PoC is to use such graphene photodetectors as an enabling technology for integrated optoelectronic systems with extremely high data rates. The new technology will be fully integrated and allow the utilization of the entire transmission window of optical fibers. Such systems have the potent",{"id":495,"funder":7,"programme":8,"title":496,"piName":10,"institution":497,"country":43,"year":13,"amount":14,"abstract":498},"cordis-european-research-council-award-862258","THINK: TeraHertz emitting INK","THE UNIVERSITY OF SUSSEX","This ERC proof-of-concept (PoC) award will enable the creation of application-ready prototypes of THINK, i.e. Terahertz (THz) emitting ink.  Terahertz radiation (typically 0.3-3THz) is one of the less-accessible parts of the electromagnetic spectrum, as many technologies and methodologies available in optics and microwaves, which limit the THz band at the two sides of the spectrum, cannot be directly applied there. THz technologies are still relatively expensive, they are very difficult to scale",{"id":500,"funder":7,"programme":8,"title":501,"piName":10,"institution":502,"country":37,"year":13,"amount":503,"abstract":504},"cordis-european-research-council-award-840010","MINIaturitzed coherent soft X-ray source for research and industry","FUNDACIO INSTITUT DE CIENCIES FOTONIQUES","€149,831","X-rays are a prime analytical tool across a diverse range of areas in our modern economy—from fundamental physics and chemistry research, to the pharmaceutical and semiconductor industries. In particular, sources of ultrafast coherent x-rays are expected to have a transformative impact in all of these areas due to their capacity to enable the study of interactions between charge carriers and atoms in gases, liquids and solids, in real-time, and with element specificity. Ease of use, compactness ",{"id":506,"funder":7,"programme":8,"title":507,"piName":10,"institution":508,"country":37,"year":13,"amount":14,"abstract":509},"cordis-european-research-council-award-874481","Computational design and prototyping of acoustic metamaterials for tailored insulation of noise","CENTRE INTERNACIONAL DE METODES NUMERICS EN ENGINYERIA","The PoC METACOUSTIC aims at designing (by resorting to the cutting-edge computational modeling and design techniques arisen from the ERC Advanced grant COMP-DES-MAT), prototyping and testing Locally Resonant Acoustic Metamaterial (LRAM) products (panels and liners) for tailored insulation of ambient noise, to be used in building construction, civil engineering, transportation, and other industrial and social environments.The highly innovative solution that METACOUSTIC offers to the market is a b",{"id":511,"funder":7,"programme":8,"title":512,"piName":10,"institution":513,"country":514,"year":13,"amount":14,"abstract":515},"cordis-european-research-council-award-862077","Aiding Antibiotic Development with Deep Analysis of Resistance Evolution","HUN-REN SZEGEDI BIOLOGIAI KUTATOKOZPONT","HU","The inappropriate use of antibiotics has rapidly accelerated antibiotic resistance evolution in pathogens, rendering several existing antibiotics ineffective. However, many pharmaceutical companies have discontinued their antibiotic research programs. This is foremost due to the rapid spread of multi-drug resistant bacteria, which makes the commercial success of new antimicrobial drugs unpredictable. Antibiotic developers do not have a toolset to appropriately test antibiotic candidates for resi",{"id":517,"funder":7,"programme":8,"title":518,"piName":10,"institution":519,"country":413,"year":13,"amount":520,"abstract":521},"cordis-european-research-council-award-825995","Behaviour Phenotyping using Inertial Sensors","FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD","€149,820","Behavior is ultimately the observable output of the nervous system. Thus, to properly diagnose and monitor nervous system disorders it is crucial that we assess behavior comprehensively. However, every day clinical practice still relies mostly on subjective methods to evaluate behavior. The ability to adequately analyse behaviour is also critical during drug development, from the preclinical (animal models) to the clinical stages.  Results from our ERC-funded work revealed that the combination o",{"id":523,"funder":7,"programme":8,"title":524,"piName":10,"institution":344,"country":145,"year":13,"amount":14,"abstract":525},"cordis-european-research-council-award-875577","Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics","Since the invention of integrated circuits, there has been a persistent incentive towards miniaturization. An indispensable part of every chip is a multi-level wiring system fabricated on top of the semiconductor layer containing the transistors. As transistors get smaller and more densely packed, the complexity and the impact on performance of the on-chip interconnects rises. The non-zero resistance and capacitance associated with the metal wires and the dielectric medium between them induce cr",{"id":527,"funder":7,"programme":8,"title":528,"piName":10,"institution":529,"country":145,"year":13,"amount":14,"abstract":530},"cordis-european-research-council-award-875528","Bioactive coating to prevent catheter infection and thrombosis","UNIVERSITE DE LIEGE","Peripheral and central venous catheters are among the most implanted blood-contacting medical devices for short and long-term clinical applications, respectively. Despite implementations of in-hospital measures, catheters are often subject to infection and thrombotic complications, which result in longer hospitalization stay, higher health care costs, or even death.   The CMD-COAT project aims at providing an innovative and rapid solution to this major medical, economical and societal need.  The",{"id":532,"funder":7,"programme":8,"title":533,"piName":10,"institution":194,"country":43,"year":13,"amount":14,"abstract":534},"cordis-european-research-council-award-862111","Pulsed Electrophoretic Deposition to give Membranes for Regenerative Medicine","Collagen membranes are a major tool in wound regeneration, encouraging cell growth, providing barrier functions, and improving cosmetic outcomes, with the market of membranes for dental wound repair alone expected to nearly double to $200m by 2023. Currently used membranes however suffer a range of limitations in size, shape, and biocompatibility, making surgeries complex and the wound healing behaviour hard to predict. As such, there is a need for new collagen based membranes to help both clini",{"id":536,"funder":7,"programme":8,"title":537,"piName":10,"institution":127,"country":128,"year":13,"amount":14,"abstract":538},"cordis-european-research-council-award-862028","Next generation eco-friendly, microbiome preserving and reduced resistance therapeutics","The rapid emergence and spread of Multi-drug Antimicrobial Resistance (AMR), alongside the negligible efforts of the major pharmaceuticals companies in the development of new antibiotics, result in a major global concern of modern medicine. Moreover, the currently clinically used antibiotics contaminate the environment and may harm the human microbiome, causing unpredictable health concerns. We discovered that by targeting species-specific ribosome unique structural motifs, identified by us, usi",{"id":540,"funder":7,"programme":8,"title":541,"piName":10,"institution":157,"country":158,"year":13,"amount":14,"abstract":542},"cordis-european-research-council-award-862311","Scanning Droplet Tribometer for Characterizing Surface Wetting Properties","Superhydrophobic surfaces repel water to great extent, that droplets in contact with such surface have spherical shape, featuring high contact angle (>150°) and low friction. The classic measurement technique for their characterization is contact angle measurement, though that technique faces serious challenges for superhydrophobic characterization, as optical accuracy for high contact angles is poor, and local variations in wetting cannot be easily probed. Here we develop the proof of concept f",{"id":544,"funder":7,"programme":8,"title":545,"piName":10,"institution":546,"country":334,"year":13,"amount":14,"abstract":547},"cordis-european-research-council-award-825403","Enhancing recovery from eating and weight disorders using mHealth and psychological theory","PARIS-LODRON-UNIVERSITAT SALZBURG","Smartphones are ubiquitous in all age groups and socioeconomic levels and digitalization of various life domains is in fullprogress. While there are several areas where skepticism is justified, the personal health domain still holds high promises, particularly when applied in specific settings. The proposed mHealth app SmartEater provides intelligent mobile logging of stress, and eatingbehavior as a basis for intervention and follow-up care in clinics treating eating disorders and obesity. Curre",{"id":549,"funder":7,"programme":8,"title":550,"piName":10,"institution":402,"country":60,"year":13,"amount":14,"abstract":551},"cordis-european-research-council-award-862078","MAssive intracellular REcording for Pharmacology","Due to the vital role of the heart, cardiac safety assessment has become one of the major gatekeepers in all stages of the drug development process, increasing costs and resources required for new drugs. Despite the recent advancements of the Comprehensive In vitro ProArrhythmia (CiPA) initiative, there are still important obstacles related to chronic cardiotoxicities and to unreliable cell models. Thus, there is a strong need for new solutions that can improve the efficacy of drug development p",{"id":553,"funder":7,"programme":8,"title":554,"piName":10,"institution":555,"country":43,"year":13,"amount":14,"abstract":556},"cordis-european-research-council-award-860277","Commercial feasibility of an anti-bacterial treatment","THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS","Multidrug resistance of pathogenic bacteria has become a serious threat to public health. The need to develop novel technologies to combat the evolution of bacterial drug resistance is clearly a matter of public concern and urgency. The consequences of AMR include (i) reducing our ability to treat common infectious, resulting in prolonged illness and a greater risk of complications; (ii) patients remaining infectious for longer due to ineffective treatments, making them more likely to pass infec",{"id":558,"funder":7,"programme":8,"title":559,"piName":10,"institution":194,"country":43,"year":13,"amount":14,"abstract":560},"cordis-european-research-council-award-812994","Making AML treatment a clinical reality:  A novel anti-IL7 receptor antibody to deliver Lap to 5LO positive cells","Acute Myeloid Leukemia (AML), a cancer of the myeloid line of blood cells, is the most common type of leukemia in adults (~350.000 new cases yearly worldwide), yet continues to have the lowest overall survival rate of all leukemias (26.9%). The disease is characterized by clonal expansion of undifferentiated myeloid precursors, leading to anomalous hematopoiesis and bone marrow failure. Current AML management still relies largely on intensive chemotherapy and allogeneic hematopoietic stem cell t",{"id":562,"funder":7,"programme":8,"title":563,"piName":10,"institution":564,"country":134,"year":13,"amount":14,"abstract":565},"cordis-european-research-council-award-862254","Extended short-wave infrared pulsed fibre laser","ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE","The 2+ um short-wave infrared spectral band has been gaining constant momentum in the recent years, driven by a plethora of potential applications whose performances could be improved either in terms of sensitivity, security, reach or efficiencies. Opening this wavelength range for widespread usage necessarily requires developing new technologies such as fibre lasers, which have already found wide use at 1.0 and 1.5 um. We propose in this ERC Proof of Concept project SWIP to move our nanosecond ",{"id":567,"funder":7,"programme":8,"title":568,"piName":10,"institution":564,"country":134,"year":13,"amount":14,"abstract":569},"cordis-european-research-council-award-842349","SenFlex: the first truly smart and flexible fiber sensor","Smart fabrics remain a promising market opportunity, however one that has not lived up to its potential yet. One of the key issues with current smart fabrics lies in the production methods and the strategy to impart functionalities. These rely on the integration of meshes of rigid electronics, or arrays of conductive yarns on soft mats or tissues. This heavily affects the fabrication and connection, costs, robustness and user’s experience of current smart fabrics. The SENFLEX project proposes a ",{"id":571,"funder":7,"programme":8,"title":572,"piName":10,"institution":564,"country":134,"year":13,"amount":14,"abstract":573},"cordis-european-research-council-award-875660","BRAIN-ACTUATED SPINAL CORD STIMULATION TO RESTORE GAIT AFTER PARALYSIS","Spinal cord injury (SCI) leads to severe motor impairments that significantly alter the quality of life of affected people and incur substantial cost for families and society. The ideas developed within the framework of our ERC starting and Consolidator grants led to the development of neurotechnologies that restored walking in paralyzed individuals. This treatment involves the delivery of targeted electrical spinal cord stimulation protocols that reactivate the spinal cord below the injury and ",{"id":575,"funder":7,"programme":8,"title":576,"piName":10,"institution":564,"country":134,"year":13,"amount":14,"abstract":577},"cordis-european-research-council-award-862082","Asynchronous Trustworthy Transactions","Although Nakamoto’s original blockchain protocol has spurred significant innovation and financial interest in the last decade, its energy consumption  becomes problematic. Besides, transaction latencies are prohibitively high and the system sustains a very low throughput. We have witnessed hundreds of alternative solutions in the last decade. Each seeks to reduce energy consumption, to obtain lower latency, or to improve throughput. All proposed alternatives, however, sacrifice either trustworth",{"id":579,"funder":7,"programme":8,"title":580,"piName":10,"institution":564,"country":134,"year":13,"amount":14,"abstract":581},"cordis-european-research-council-award-862528","Photonic Integrated Microcombs as Multi-wavelength Sources for Edge Data Centers","Over the past ten years the Laboratory of Photonics and Quantum Measurements (LPQM) has developed and pioneered microcombs – photonic integrated optical frequency combs (OFC), providing access to equidistant optical carriers. Due to their broad bandwidth, high repetition rates, compactness and wafer-scale fabrication, such microcombs represent a novel disruptive technology with a proven track record. While their advantages were shown in ultrafast ranging (LIDAR), high-speed coherent telecommunic",{"id":583,"funder":7,"programme":8,"title":584,"piName":10,"institution":564,"country":134,"year":13,"amount":14,"abstract":585},"cordis-european-research-council-award-862291","Development of a trivalent epitope-focused RSV vaccine to boost pre-existing immunity","The development of a Respiratory Syncytial Virus (RSV) vaccine is deemed a global health priority by the World Health Organization. Globally, RSV causes 33 million episodes of infection and up to 120,000 deaths annually. The most affected populations are pre-term infants, young children and the elderly. Several decades of intensive research are yet to yield a clinically approved vaccine. This failure is mostly attributed to sophisticated viral mechanisms that prevent the induction of protective ",{"id":587,"funder":7,"programme":8,"title":588,"piName":10,"institution":589,"country":43,"year":13,"amount":14,"abstract":590},"cordis-european-research-council-award-861942","Validation of a novel class of cyclophilin inhibitors for the treatment of non-alcoholic steatohepatitis","THE UNIVERSITY OF EDINBURGH","Non-alcoholic steatohepatitis (NASH) is an increasingly prevalent chronic liver disease (3-4% of the US population) for which there is currently no approved drug therapy. In the absence of innovative treatments healthcare costs associated with this disease are set to triple over the next decade. To address this unmet medical need, the pharmaceutical industry is currently pursuing a range of liver fibrosis drug discovery programs based on different mode of actions. A compelling mechanism for trea",{"id":592,"funder":7,"programme":8,"title":593,"piName":10,"institution":594,"country":12,"year":13,"amount":14,"abstract":595},"cordis-european-research-council-award-836429","PROtotype Demonstration Using low-cost Catalysts for Electrolysis to H2","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","Hydrogen (H2) generated from renewable energies, such as solar and wind, and water has a huge potential as a carbon-free energy vector which can be exploited on demand through fuel cell technologies. Proton-exchange membrane electrolysers (PEMEL) are a mature technology that can be coupled with intermittent renewable power sources. However their wide deployment still depends on innovative breakthroughs regarding the design of alternative catalysts avoiding the use of precious metals and fulfilli",{"id":597,"funder":7,"programme":8,"title":598,"piName":10,"institution":344,"country":145,"year":13,"amount":14,"abstract":599},"cordis-european-research-council-award-825108","High resolution Miniature Implantable nerve Stimulator for Electroceutical Research (HiMISER)","In my ERC project ‘µThalys’, we are researching future concepts for electronic medical implants. The main idea is to replace current medical implants that typically consist of a titanium casing with electronics and a few lead wires with less intrusive, softer, tissue-like implants. These future generation implants consist of soft, modular, miniature transducer nodes that can act stand-alone, or be connected in a network, thus forming e.g. an implantable sensor network.  Now, the main idea drivin",{"id":601,"funder":7,"programme":8,"title":602,"piName":10,"institution":564,"country":134,"year":13,"amount":14,"abstract":603},"cordis-european-research-council-award-824886","Surface Engineering for Thermal Water Separation","We propose to alter the surface topography and morphology of titanium substrates for phase change heat transfer enhancements using the electrochemical techniques developed in an ERC consolidator grant. The alteration efforts will result in enhanced heat transfer efficiency. The modified titanium substrate will be used to fabricate a thermally enhanced heat exchange device, which will then be used to construct a novel thermal water separation system based on a multi-effect ‘hybrid’ distillation c",{"id":605,"funder":7,"programme":8,"title":606,"piName":10,"institution":105,"country":43,"year":13,"amount":14,"abstract":607},"cordis-european-research-council-award-862204","Ultrasensitive detection of transmissible malaria","Malaria affects millions around the globe. Affordable and accurate point-of-care diagnostic tests are needed for those in low- or middle-income countries as well as developed areas. Currently, only diagnostic tests for infection are available and are most commonly designed to detect histidine-rich protein 2 (HRP2), though HRP2-negative parasites evolved and escape detection by these tests. In addition to detecting and curing infection, another important strategy against malaria is battling trans",{"id":609,"funder":7,"programme":8,"title":610,"piName":10,"institution":350,"country":60,"year":13,"amount":14,"abstract":611},"cordis-european-research-council-award-875129","Blue light remote analgesia with K+ channels","Chronic pain (CP) is a medical condition affecting around 20% of adults in Europe, characterised by an abnormal duration of pain (> 12 weeks) originally initiated by a trauma or illness. Despite significant progress, CP remains extremely hard to treat, with only one-third to two-thirds of patients reporting adequate some pain relief. This situation is even worse for neuropathic pain (NP), a specific class of CP affecting 8% of global population and whose origin mostly depend on peripheral or cen",{"id":613,"funder":7,"programme":8,"title":614,"piName":10,"institution":127,"country":128,"year":13,"amount":14,"abstract":615},"cordis-european-research-council-award-838702","High-Voltage Micro-Photovoltaic Cells and Photodetectors Based on Guided Nanowires for On-Chip Powering of Autonomous Microsystems","The Internet of Things (IoT) relies on billions of autonomous miniaturized sensor nodes deployed over the environment, homes, offices, and our own clothes and bodies. Powering these sensors creates a huge and urgent demand for smaller devices capable of harvesting energy from the environment and supplying the required power characteristics. Photovoltaic (PV) cells are attractive sources of renewable energy in illuminated environments, but their output voltage is limited to a few volts, whereas M",{"id":617,"funder":7,"programme":8,"title":618,"piName":10,"institution":133,"country":134,"year":13,"amount":14,"abstract":619},"cordis-european-research-council-award-842790","CellProbe: Microfluidic probe for simultaneous tagging and extraction of single cells","Having developed a liquid scanning probe - microfluidic probe (MFP) - for creating spatially-defined microscale biochemical environments and microscale molecular assays within the ERC-BioProbe project, in this proof-of-concept project, - CellProbe - we seek to leverage this technology toward realization of a commercially viable single-cell analysis platform",{"id":621,"funder":7,"programme":8,"title":622,"piName":10,"institution":144,"country":145,"year":13,"amount":623,"abstract":624},"cordis-european-research-council-award-825972","Data science tool for Epidemic FOrecastinG","€131,563","Several organisations active in the health care market make decisions based on an estimation of the number of individuals infected with an infectious disease. These organisations benefit from a timely and trust-worthy prediction of the number of infected individuals. To date, infectious disease predictions tools are inadequate because they typically include limited and domain-specific data and because the translation to impact for specific stakeholders in the healthcare market is lacking. DEFOG ",{"id":626,"funder":7,"programme":8,"title":627,"piName":10,"institution":628,"country":37,"year":13,"amount":629,"abstract":630},"cordis-european-research-council-award-825798","Off-the-Shelf Polypeptide-based Immunotherapy for Advanced Melanoma Treatment","FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPE FELIPE","€149,938","Despite various existing drug delivery methods, the key challenge remains: how to deliver drugs to the desired site of therapeutic action to achieve best treatment outcome, while minimising side effects? This is even more challenging in cancer immunotherapy as a complex interplay of immune reactions need to be activated. POLYMMUNE will evaluate the technical and commercial viability of our novel polymeric nanocarrier platform (developed during my ERC Consolidator grant MyNano) for targeted drug ",{"id":632,"funder":7,"programme":8,"title":633,"piName":10,"institution":634,"country":43,"year":13,"amount":14,"abstract":635},"cordis-european-research-council-award-840295","A device enabling quantification of molecular and nanoparticle diffusion within thin solvated films","UNIVERSITY OF LEEDS","The objective of the DIFFUSION project is to develop an easy-to-use device to analyse diffusion processes within thin solvated films. This new analytical tool will overcome a current bottleneck in the development of functional coatings for a wide range of applications, from fundamental research in biophysics and microbiology to real-life applications in biomaterials and paints.Driven by analytical needs during the ERC Starting Grant project JELLY my team and I conceived the DIFFUSION technology.",{"id":637,"funder":7,"programme":8,"title":638,"piName":10,"institution":639,"country":145,"year":13,"amount":14,"abstract":640},"cordis-european-research-council-award-861957","A web-based Decision Support System to score forest understorey dynamics in response to management interventions in a changing world","UNIVERSITEIT GENT","Currently, forest management models focus predominantly on tree dynamics following interventions, and tend to ignore the plant species found below the trees on the forest floor (the understorey). This is a crucial oversight, as the understorey is the major component of biodiversity, provides vital ecosystem services, and can influence the overall functioning of the forest. As such, there is a need for a user-friendly tool to help predict key understorey plant performance indicators (e.g. biodive",{"id":642,"funder":7,"programme":8,"title":643,"piName":10,"institution":644,"country":288,"year":13,"amount":645,"abstract":646},"cordis-european-research-council-award-840116","Vis-NIR Hyperspectral imaging for biomaterial quality control","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","€149,923","The purpose of the proposed ERC POC project, as distinct to the parent ERC project, is to develop a rapid, cost effective solution to evaluate the quality of the entire surface of a biomaterial.",{"id":648,"funder":7,"programme":8,"title":649,"piName":10,"institution":639,"country":145,"year":13,"amount":650,"abstract":651},"cordis-european-research-council-award-839200","Bit-interleaved sigma-delta modulation over fiber","€149,970","Network operators are struggling on how to release broadband mobile services in highly dense and hot-spot scenarios. The 5th generation of mobile networks is targeting per user downlink and uplink rates of 300 Mb\u002Fs and 50 Mb\u002Fs respectively. In ultra-dense environments such as stadiums, airports, shopping malls and tourist hot-spots, the aggregated bit rate becomes enormous. To make it more concrete, Belgium’s national football stadium (King Baudouin) is taken as example. The stadium can accommod",{"id":653,"funder":7,"programme":8,"title":654,"piName":10,"institution":655,"country":117,"year":13,"amount":14,"abstract":656},"cordis-european-research-council-award-862089","Ex vivo cell labelling for in vivo imaging applied to cell therapeutics","CENYA IMAGING B.V.","While we do not possess magic, modern day medicine can sometimes approach the unbelievable - curing cancer or repopulating diseased heart tissue; all possible due to the advent of cell therapy. However, cell therapy has fallen far short of expectations. Its success requires the ability to monitor and optimise treatments in real time for each individual; necessitating a direct means of monitoring transferred cells. Noninvasive imaging techniques are essential to the success of modern therapeutics",{"id":658,"funder":7,"programme":8,"title":659,"piName":10,"institution":660,"country":25,"year":13,"amount":661,"abstract":662},"cordis-european-research-council-award-825892","Automated high resolution water sampler for environmental monitoring","GFZ HELMHOLTZ-ZENTRUM FUR GEOFORSCHUNG","€149,711","A new automated water sampling technology was developed under the ERC Consolidator Grant STEEPclim with the potential to revolutionize environmental monitoring worldwide. A changing climate and growing scarcity of water strongly increase the need of reliable standardized and highly automated environmental monitoring, thus creating a growing market for our innovative solution. Our first prototype successfully operated under field conditions. Now we seek funding to further develop this device and ",{"id":664,"funder":7,"programme":8,"title":665,"piName":10,"institution":477,"country":117,"year":13,"amount":14,"abstract":666},"cordis-european-research-council-award-861895","Structurally Engineered 3D Printed Architectures for Scalable Tissue Engineering","Engineering tissues with a hierarchical vascular network, which is the goal of our ERC project VascArbor, is challenging. Developments in the field of biofabrication, including 3D bioprinting, are promising to cope with this challenge. However, current strategies lack the capacity to create hierarchical, high resolution, cost efficient, upscalable constructs in a standardized manner with a single approach. Embedded bioprinting, allowing the deposition of complex constructs without the need of a ",{"id":668,"funder":7,"programme":8,"title":669,"piName":10,"institution":670,"country":37,"year":13,"amount":10,"abstract":671},"cordis-european-research-council-award-842606","Ultrastrong Composites through Polymers Interlocked with carbon NanoTubes","FUNDACION IMDEA NANOCIENCIA","The reinforcement of polymers with carbon nanotube fillers has been one of the most active areas of research in CNT science. Several materials where the mechanical and\u002For electrical properties of polymers have been significantly improved using nanotube fillers have been demonstrated. However, the improvement in mechanical properties of the CNT-polymer composites remains far behind the idealized theoretical predictions. These disappointing experimental results are due to a combination of imperfec",{"id":673,"funder":7,"programme":8,"title":674,"piName":10,"institution":221,"country":134,"year":13,"amount":14,"abstract":675},"cordis-european-research-council-award-862346","Automated super-resolution polarimetric nonlinear microscope 'PolarNon'","The analysis of materials is a key requirement for device quality control in medical, electronic and photonic industry. Currently, fluorescence imaging, electron microscopy and photoluminescence are typical tools for quality control in research and industry. However, they suffer from several limitations: complex samples preparation, special environments, destructive and time-consuming measurements. The development of new materials and components needs innovative approaches for fast and non-destr",{"id":677,"funder":7,"programme":8,"title":678,"piName":10,"institution":679,"country":413,"year":13,"amount":14,"abstract":680},"cordis-european-research-council-award-825508","Selective retention of VEGF for cancer and retinopathies therapeutics","INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES","Angiogenesis is the mechanism of blood vessel formation from pre-existing ones and is vital for nutrient and oxygen delivery to all cells in the organism. However, dysregulation of angiogenesis is detrimental for the organism. Excessive or abnormal angiogenesis is a hallmark of cancer and various retinopathies and favours tumour growth and metastasis, and vision loss, respectively. Excessive or abnormal angiogenesis is fuelled by hypoxia-driven expression of high levels of vascular endothelial g",{"id":682,"funder":7,"programme":8,"title":683,"piName":10,"institution":684,"country":117,"year":13,"amount":14,"abstract":685},"cordis-european-research-council-award-839325","TArgeTed molecular Imaging and surgery for gastro-intestinal Cancer","ACADEMISCH ZIEKENHUIS LEIDEN","The treatment for cancer patients is shifting from population-based treatment to the more precise personalized medicine. Tumor-specific molecular diagnostics and treatment are an example of this phenomena to assist clinical decision making and to improve treatment strategies for patients. This change in management will lead to societal benefits such as treatments that fits the patient’s needs and therefore, increased health benefits and increased quality-of-life. The targeted agent we have devel",{"id":687,"funder":7,"programme":8,"title":688,"piName":10,"institution":689,"country":37,"year":13,"amount":14,"abstract":690},"cordis-european-research-council-award-838002","Peptide Dynamic Amphiphiles for Gene Therapy and Macromolecular Delivery","UNIVERSIDAD DE SANTIAGO DE COMPOSTELA","The delivery of exogenous nucleic acids and related macromolecules is one of the most encouraging tools for the future of human health. However, the delivery of the required genetic cargo still constitutes an important challenge. Although non-viral vectors are still in their preliminary clinical steps they are rising up as a real alternative for gene therapeutics. Oligopeptides and polymer cell penetrating materials constitute one of the most promising alternatives for the protection, transport ",{"id":692,"funder":7,"programme":8,"title":693,"piName":10,"institution":634,"country":43,"year":13,"amount":14,"abstract":694},"cordis-european-research-council-award-842394","Development of RGD-therapeutics for cardio-metabolic disease","In Europe, 58 million people are living with type 2 diabetes and 36 million people are at risk of developing the condition. Macrovascular disease is the commonest cause of morbidity and mortality in type 2 diabetes, yet current diabetes therapies have failed to consistently reduce cardiovascular events. In my Starting Grant, I discovered that a circulating protein, IGF binding protein-1, possesses several favourable characteristics– including insulin sensitisation, amelioration of glucose intole",{"id":696,"funder":7,"programme":8,"title":697,"piName":10,"institution":139,"country":128,"year":13,"amount":14,"abstract":698},"cordis-european-research-council-award-862580","Predicting clinical response to anticancer drugs using 3D-bioprinted tumor models for personalized therapy","Predicting clinical response to novel and existing anticancer drugs remains a major hurdle for successful cancer treatment. Studies indicate that the tumor ecosystem, resembling an organ-like structure, can limit the predictive power of current therapies that were evaluated solely on tumor cells. The interactions of tumor cells with their adjacent microenvironment are required to promote tumor progression and metastasis, determining drug responsiveness. Such interactions do not form in standard ",{"id":700,"funder":7,"programme":8,"title":701,"piName":10,"institution":702,"country":334,"year":13,"amount":14,"abstract":703},"cordis-european-research-council-award-862507","Diagnostic drug response-profiling using SLAMseq","FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH","One of the greatest challenges today is to select the right drug for the right patient at the right time. A lack of diagnostic tools for predicting therapy response currently hampers patient-tailored treatment decisions in the clinic with severe implications for economy and – most importantly – patient survival. Profiling transcriptional responses to drug treatment is a key method for probing the activity of targeted therapeutics and guiding their use in the clinic. A major limitation of establi",{"id":705,"funder":7,"programme":8,"title":706,"piName":10,"institution":707,"country":117,"year":13,"amount":14,"abstract":708},"cordis-european-research-council-award-839088","A Technology for the Generation of Stable Enzymes","STICHTING VU","The general awareness towards a sustainable life style is growing in society. This translates into a growing market for services and products that involve environment-friendly chemistry and material loops. Biotechnology will be one the key drivers when aiming for a circular economy, as it facilitates green chemistry and efficient recycling processes. A central component of most biotechnological processes are biocatalytic proteins (so-called enzymes). However, enzymes are intrinsically vulnerable",{"id":710,"funder":7,"programme":8,"title":711,"piName":10,"institution":455,"country":128,"year":13,"amount":14,"abstract":712},"cordis-european-research-council-award-839297","Modulating skin innervation to treat cutaneous inflammation","Skin disease is one of the most common human illnesses. At any given time, approximately one out of three individuals is affected by skin disease and it is the 18th leading cause of health burden worldwide. Despite this profound impact, skin disease continues to receive relatively little attention in global health forums, and the etiology of most of these conditions is unclear. The skin is our major interface with the external world, densely innervated with sensory and autonomic nerve fibers. Th",{"id":714,"funder":7,"programme":8,"title":715,"piName":10,"institution":716,"country":25,"year":13,"amount":14,"abstract":717},"cordis-european-research-council-award-875564","Large Area Aerogel Catalyst","TECHNISCHE UNIVERSITAET DRESDEN","Polymer electrolyte membrane fuel cells (PEMFCs) have attracted considerable worldwide attention because of their high energy conversion efficiency and low environmental impact. Their commercialization, however, is inhibited by the high loadings of the costly catalyst materials used at their cathodes, which is in turn related to their insufficient oxygen reduction activity and inadequate long-term stability. A promising solution that simultaneously addresses all these issues is the design of pur",{"id":719,"funder":7,"programme":8,"title":720,"piName":10,"institution":721,"country":60,"year":13,"amount":14,"abstract":722},"cordis-european-research-council-award-874596","Wavefront shaping system for nonlinear fiber-based microscopy and endoscopy","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","The WAVESCOPE project is about exploiting a novel optical concept recently introduced by the PI in the domain of medical imaging.  This concept deals with the frontier research topic in the photonics, i.e.  the self-control of the spatial quality of optical beams in multimode nonlinear optical fibers.  The WAVESCOPE technology is poised to enable a breakthrough in the clinical domain, providing for the first time ever the stable delivery of high power and strongly focused optical beams with mult",{"id":724,"funder":7,"programme":8,"title":725,"piName":10,"institution":194,"country":43,"year":13,"amount":726,"abstract":727},"cordis-european-research-council-award-825238","CellsBox: a modular system for automated cell imaging experiments","€149,931","Based on research from ERC CoG HydroSync where we developed both hardware and software approaches to cell imaging, we are in the position to develop translationally a cell culture and imaging unit, with integrated modular hardware and analysis software allowing automated robust performance. This promises to not just significantly bring down the costs for a broad spectrum of cell biology and single cell imaging experiments. It will also make these experiments more reproducible, systematic and eas",{"id":729,"funder":7,"programme":8,"title":730,"piName":10,"institution":402,"country":60,"year":13,"amount":14,"abstract":731},"cordis-european-research-council-award-832045","Advanced in vitro physiological models: Towards real-scale, biomimetic and biohybrid barriers-on-a-chip","This project is focused on the design, the production, the characterization, and the proposal for future commercialization of the first 1:1 scale 3D-printed realistic model of the brain tumor microenvironment with its associated blood neurovasculature. The proposed biomimetic dynamic 3D system, characterized by microcapillary diameter size and fluid flows similar to the in vivo physiological parameters, represents a drastic innovation with respect to other models well-established in the literatu",{"id":733,"funder":7,"programme":8,"title":734,"piName":10,"institution":273,"country":134,"year":13,"amount":735,"abstract":736},"cordis-european-research-council-award-840243","Biocatalytic Methyltransferase Cascades","€149,760","The goal of this project is to develop a general system for preparative enzyme-catalyzed methylation reactions. Selective methylation of complex molecules can be challenging for synthetic chemistry. Given the exquisite chemo-, regio- and stereoselectivities of enzyme catalysis we believe that biocatalysis presents a powerful alternative for commercial production of pharmaceuticals and fine chemicals. In this project we demonstrate the applicability and commercial viability of a novel enzyme-base",{"id":738,"funder":7,"programme":8,"title":739,"piName":10,"institution":502,"country":37,"year":13,"amount":14,"abstract":740},"cordis-european-research-council-award-862149","Room Temperature Magnetic Resonance Force Microscopy","Magnetic resonance imaging (MRI) enables three-dimensional images to be created in a non-destructive and safe manner. Mechanical resonators can greatly increase the sensitivity of MRI compared to commercial systems. Considerable effort is being expended to push magnetic resonance imaging down to single atom resolution. This is currently done by applying large-amplitude magnetic pulses at milliKelvin temperatures. However, these large-amplitude pulses generate heating, creating a roadblock for re",{"id":742,"funder":7,"programme":8,"title":743,"piName":10,"institution":744,"country":37,"year":13,"amount":14,"abstract":745},"cordis-european-research-council-award-811220","Therapeutic immunotherapy targeting NG2 and CD22 antigens for MLL-rearranged and MLL-germline B-cell Acute Lymphoblastic Leukemia","FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS","B-ALL is the commonest cancer of childhood. There remain childhood B-ALL subgroups with dismal prognosis such as infant B-ALL and B-ALL carrying MLL rearrangements (MLLr). In addition, the prognosis of adult B-ALL is worse, and refractory\u002Frelapse (R\u002FR) B-ALL remains dismal. CD19-targeted immunotherapies have emerged as promising therapeutic approaches for R\u002FR B-ALL. CD19 CAR T-cells have shown impressive efficacy in R\u002FR B-ALL. However, relatively rapid relapses are frequently observed, a proport",{"id":747,"funder":7,"programme":8,"title":748,"piName":10,"institution":749,"country":128,"year":13,"amount":14,"abstract":750},"cordis-european-research-council-award-875197","Toward the Commercialization of a Proteolytically Resistant APPI Variant for Inhibiting Metastasis in Prostate and Pancreatic Cancer","BEN-GURION UNIVERSITY OF THE NEGEV","Distal site tumor metastasis is the leading cause of prostate- and pancreatic-cancer-related deaths; nevertheless, standard-of-care (SoC) treatments and other targeted therapies under development are based on their activity against the primary tumors rather than on their anti-metastatic activity. There is consequently an urgent medical need for new agents targeting the metastatic process. In prostate and pancreatic cancer models, the serine protease mesotrypsin promotes tumor invasion and metast",{"id":752,"funder":7,"programme":8,"title":753,"piName":10,"institution":754,"country":60,"year":13,"amount":14,"abstract":755},"cordis-european-research-council-award-824939","Automatic System Testing","UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA","Verifying the correctness of software systems requires extensive and expensive testing sessions. While there are tools and methodologies to efficiently address unit and integration testing, system testing is still largely the result of manual effort.Testing software applications at the system level requires executing the applications through their interfaces to verify the correctness of their functionalities and stimulate all their layers and components. Automating just part of this process can ",{"id":757,"funder":7,"programme":8,"title":758,"piName":10,"institution":231,"country":37,"year":13,"amount":14,"abstract":759},"cordis-european-research-council-award-875018","MAGIC-SWITCH: Magnetic Switch Controlled with Voltage","We are living in a world that is increasingly driven by data. Governments, healthcare facilities, commercial businesses and individuals are all storing information in electronic form. This has led to the emergence of digital and cloud-based technologies. The ability to use information more efficiently has resulted in a rapid increase of the value of information. However, with the Big Data revolution, information is facing new challenges. Energy efficiency during writing of magnetic information n",{"id":761,"funder":7,"programme":8,"title":762,"piName":10,"institution":763,"country":12,"year":13,"amount":14,"abstract":764},"cordis-european-research-council-award-841560","incPRINT as a platform for RNA-targeted drug discovery","INSTITUT CURIE","RNA transcripts have emerged as key regulators of diverse biological phenomena and are implicated in many human diseases including neurodegenerative disorders, cancers, viral infections and antibiotic resistance. As such, RNA represents an untapped source of therapeutic targets. Bioavailable small molecules have been recently successfully applied to target RNA. One caveat, however, is that lead compounds are not easily designed from RNA sequence or structure and therefore targeting RNA by small ",{"id":766,"funder":7,"programme":8,"title":767,"piName":10,"institution":139,"country":128,"year":13,"amount":14,"abstract":768},"cordis-european-research-council-award-875586","PepZoSkin: Biocompatible Self-powered Electronic Skin","Electronic skin is seen as the next generation of wearable technology, ideally made of thin, self-powered, self-healing and flexible electronics able to mimic or augment natural skin functionalities.Smart prostheses to give amputees the sense of touch, completely biocompatible skin patches for wound care, or new on-skin drug delivery systems are only few e-skin applications that are being explored by the research community for the last several years.The main problems hindering the e-skin revolut",{"id":770,"funder":7,"programme":8,"title":771,"piName":10,"institution":241,"country":43,"year":13,"amount":772,"abstract":773},"cordis-european-research-council-award-842174","An integrated high-throughput human cell and Drosophila screening platform for the expedited discovery of anti-ageing compounds","€149,872","The steeply increasing ageing population, and accompanying rise of age-related diseases will soon have profound societal and economic effects, making ageing research increasingly important and outcome of this grant impactful. Our most promising way to improve health in the elderly is by replicating decades of genetic finding in model organisms of healthy long-lived mutants to pharmacological approaches. This will enable transition of these findings to clinical trials. In the CancerPhagy project,",{"id":775,"funder":7,"programme":8,"title":776,"piName":10,"institution":777,"country":334,"year":13,"amount":14,"abstract":778},"cordis-european-research-council-award-825710","SLAMseq: Temporal resolution in gene expression profiling across multiple platforms","INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH","Current gene expression profiling by massive parallel RNA sequencing provides insight into relative abundance of RNA molecules but fails to resolve the underlying principles in gene regulation that are reflected in the intracellular kinetics of RNA biogenesis, processing and turnover. In the ERC-StG 'miRLIFE', we have developed a novel technology – SLAMseq – that uncovers a chemically modified nucleoside analog by sequencing. When coupled to metabolic RNA labeling and targeted RNA sequencing, SL",{"id":780,"funder":7,"programme":8,"title":781,"piName":10,"institution":782,"country":783,"year":13,"amount":14,"abstract":784},"cordis-european-research-council-award-875690","Safe Networks using P4 Programs","CORRECT NETWORKS SRL","RO","Programmable hardware dataplanes such as the Barefoot Tofino enable unprecedented network flexibility, promising an ever-evolving set of network functionalities at hardware speeds, and are being rolled out in production.  However, programming such dataplanes is very difficult as numerous bugs have been found even in trivial programs: accesses to uninitialized header fields, header stack underflows or overflows and processing of dropped packets.  Verifying P4 programs before deployment is a great",{"id":786,"funder":7,"programme":8,"title":787,"piName":10,"institution":589,"country":43,"year":13,"amount":788,"abstract":789},"cordis-european-research-council-award-838616","Fast, Flexible, and Convenient: a simple insert system for the in situ NMR analysis of very fast reactions on a modern open-access FT NMR spectrometer","€147,076","The project will involve further design and development of our methodology, developed under the ERC Advanced grant 'arylator', for variable ratio in situ stopped flow NMR. The methodology has recently been published and its power amply demonstrated in the deconvolution of the mechanism for CF3 transfer from Ruppert's reagent to electrophiles. The equipment that will developed and demonstrated under tenure of a proof of concept grant will reduce the dead time from 0.2 seconds to a matter of milli",{"id":791,"funder":7,"programme":8,"title":792,"piName":10,"institution":241,"country":43,"year":13,"amount":793,"abstract":794},"cordis-european-research-council-award-841781","Examining the use of Metamaterials for acoustic applications","€149,617","MetaSonics is an acoustic metamaterial technology that shapes sound (and ultrasound) fields. Our solution is to build an adjustable device that transforms an input acoustic wave into a time-variable, user-defined acoustic field. MetaSonics comprises of a surface made of electronically adjustable acoustic metamaterial bricks. Each brick in the surface can individually vary the phase of an incident acoustic field in order to shape the complex output field.Our vision is to manipulate sound waves us",{"id":796,"funder":7,"programme":8,"title":797,"piName":10,"institution":798,"country":117,"year":13,"amount":799,"abstract":800},"cordis-european-research-council-award-835883","Compartmentalized DNA Computers for In-Vitro Diagnostic Applications","TECHNISCHE UNIVERSITEIT EINDHOVEN","€149,770","Changes in human microRNA (miRNA) levels are associated with several important human diseases. Monitoring changes in miRNA levels would enable clinicians to perform diagnosis and evaluate therapeutic efficacy of drugs. In principle, changes in a miRNA signature could be detected by existing methods such as quantitative reverse transcription PCR (RT-qPCR). However, the experimental complexity and computational analysis of the data prevents the measurements of miRNA signatures in a clinical settin",{"id":802,"funder":7,"programme":8,"title":803,"piName":10,"institution":199,"country":117,"year":13,"amount":14,"abstract":804},"cordis-european-research-council-award-862616","Encapsulated catalysts in flow chemistry for continues chemical processes","Improvements in both the economic effectiveness and environmental impacts to the fine chemical industry are necessary to maintain European competitiveness and reduce the global environmental cost of these products. Both of these goals can be accomplished by making existing processes more efficient. Catalysts facilitate the development of efficient chemical processes and are required for the sophisticated transformations used to produce high valued pharmaceutical and fragrance products. A process",{"id":806,"funder":7,"programme":8,"title":807,"piName":10,"institution":808,"country":334,"year":13,"amount":14,"abstract":809},"cordis-european-research-council-award-862485","Thin Film Metallic Glasses for Tribological Applications","OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN","The current proposal aims to demonstrate the potential of thin film metallic glasses as novel tribological coating materials, used to improve the performance of tools, dies, and moulds in many different applications. These coatings are characterized by a high hardness, as well as high wear- and oxidation resistance. Thin film metallic glasses are promising materials to fulfil these demands. Due to their amorphous structure they have excellent mechanical properties such as high specific strengths",{"id":811,"funder":7,"programme":8,"title":812,"piName":10,"institution":194,"country":43,"year":13,"amount":14,"abstract":813},"cordis-european-research-council-award-862405","Photon Emitting Gated Arrays for Scalable On-chip quantum Systems","Single photons play in important part in the development of quantum technologies, particularly in the fields of communication and networks. There are many potential candidates of single-photon sources with varying degrees of quality and efficiency, and there is a collective push towards catapulting solid-state quantum light sources into real applications needed for the development of quantum technologies. To that end, the current ERC Consolidator Grant (from which this PoC proposal draws highly)",{"id":815,"funder":7,"programme":8,"title":816,"piName":10,"institution":817,"country":37,"year":13,"amount":14,"abstract":818},"cordis-european-research-council-award-837225","A new platform technology for the on-demand access to large acenes","FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA","The aim of PLAT_ACE is to study the technical and commercial viability of this novel synthetic methodology and its industrial implementation for the generation of nonacene and other larger acenes supported onto surfaces for use in semi-conducting devices with unprecendeted electronic properties and low bandgap. Our technology will be benchmarked against current industrial methodologies to identify the unique selling points and niche applications.We will demonstrate the application of the new ace",{"id":820,"funder":7,"programme":8,"title":821,"piName":10,"institution":194,"country":43,"year":13,"amount":822,"abstract":823},"cordis-european-research-council-award-839997","High Efficiency heAt pipes using hierarchical nano Tubes","€148,728","Modern electronic devices have flourished because of the relentless development of new lithographic processes that result in ever higher and more compact computing power. However, this increases the amount of heat generated in a decreasing volume. As a result the computing power of many modern processors is truncated to avoid thermal damage.The preferred cooling technology for portable electronic devices are heat pipes. While this technology allows for impressive cooling performances, heat pipes",{"id":825,"funder":7,"programme":8,"title":826,"piName":10,"institution":827,"country":37,"year":13,"amount":14,"abstract":828},"cordis-european-research-council-award-861930","Photocatalytic Materials for Cartridge and Microchannel Flow Reactors","UNIVERSIDAD AUTONOMA DE MADRID","During the research of the ERC-funded project UNBICAT (ERC-CoG, contract number 647550), the Principal Investigator, and his research group have developed new photocatalysts and their application in different organic transformations. A recent development of the project has been the preparation of new photocatalysts and their immobilization onto different materials, making them heterogeneous catalysts. These heterogeneous photocatalysts are able to produce chemicals and products of interest to th",{"id":830,"funder":7,"programme":8,"title":831,"piName":10,"institution":832,"country":43,"year":13,"amount":14,"abstract":833},"cordis-european-research-council-award-862102","Discovery of New Molecular Semiconductors","THE UNIVERSITY OF LIVERPOOL","This project has two main deliverables in the area of organic electronics:(i)A database of molecular semiconductors with predicted high charge mobility. This database contains molecular materials that are characterized structurally but the vast majority of its entries are not tested or intellectually protected as molecular semiconductors. The quality of our predictions was verified in a recent paper published in Nature Materials (doi:10.1038\u002FNMAT4970) and such database is therefore of great comm",{"id":835,"funder":7,"programme":8,"title":836,"piName":10,"institution":837,"country":60,"year":13,"amount":838,"abstract":839},"cordis-european-research-council-award-842429","Launch Test of Natural Biocides for the Control of Insect Borne Diseases","UNIVERSITA DEGLI STUDI DI CAMERINO","€149,685","Insect-Borne Diseases (IBDs) affecting animals and plants are an increasing problem burdening the economy and the social conditions of many countries. The growing concern is that climatic changes, globalization and increase in travel and trade have fostered the spread of insect populations in new geographic areas and with them many IBDs. It is now established that Europe must face an increasing risk of vector-borne outbreaks.Mosquito-borne infections affect millions of people all over the world ",{"id":841,"funder":7,"programme":8,"title":842,"piName":10,"institution":843,"country":43,"year":13,"amount":14,"abstract":844},"cordis-european-research-council-award-862272","Edu*Select: Developing a Commercial Platform to Deliver Teacher Selection Tools","UNIVERSITY OF YORK","Teacher selection presents a significant international challenge: UNESCO predicts that countries will need to select and train almost 69 million teachers by 2030 (UNESCO 2016). However, current teacher selection methods are largely ineffective (Goldhaber et al., 2014; Klassen & Kim, 2019), resulting in the suboptimal quality of the teacher workforce. Improving the ways in which prospective teachers are selected benefits children’s educational outcomes and a country’s social and economic health (",{"id":846,"funder":7,"programme":8,"title":847,"piName":10,"institution":848,"country":43,"year":13,"amount":14,"abstract":849},"cordis-european-research-council-award-862389","Commercialisation of Proteus","UNIVERSITY OF BRISTOL","Commercialisation of Proteus. We will develop a case for commercialisation our unique, tribrid (quadrupole mass-filter\u002Fcollision cell\u002F multi- collector) inductively coupled mass-spectrometer, dubbed Proteus, built in collaboration with industrial partners Thermo Fisher Scientific. We will explore full workflow applications to open up a business case for turning the prototype into a commercial model. We have already demonstrated its unique capabilities in traditional fields for such instrumentati",{"id":851,"funder":7,"programme":8,"title":852,"piName":10,"institution":236,"country":60,"year":13,"amount":10,"abstract":853},"cordis-european-research-council-award-842472","Crosspoint In-memoRy CompUting Systems","Every second, our smart phones deliver a wealth of information that can be used to monitor the traffic, the financial transactions, and even the spread of a dangerous disease. The processing of these big data into a meaningful information requires specific machine learning (ML) algorithms, which essentially consist of regression techniques for inference, classification and prediction. The conventional digital computers are not designed to optimally solve these problems with efficient time and en",{"id":855,"funder":7,"programme":8,"title":856,"piName":10,"institution":857,"country":25,"year":13,"amount":19,"abstract":858},"cordis-european-research-council-award-812763","Quantum Light Enterprise","UNIVERSITY OF HAMBURG","Quantum noise of laser light limits the sensitivity of many optical measurement devices. This project will proof the concept of a new innovative idea that is able to reduce the quantum noise of laser light.\"",{"id":860,"funder":7,"programme":8,"title":861,"piName":10,"institution":428,"country":158,"year":13,"amount":14,"abstract":862},"cordis-european-research-council-award-825020","BIOHYBRID AND BIODEGRADABLE NANOVACCINES FOR CANCER IMMUNOTHERAPY","The innovation of the biohybrid and biodegradable nanovaccines to be taken to proof-of-concept lies in the combination of different parts of the nanovaccine. A biohybrid and biodegradable nanovaccine shows potential to: (i) enhance cancer treatment efficacy; (ii) to be universally applicable to all cancers, regardless of the tumour in question; (iii) prolonging the survival rate of cancer patients; (iv) increase the amount of complete tumor remissions; and (v) boost of tumor-specific immune resp",{"id":864,"funder":7,"programme":8,"title":865,"piName":10,"institution":866,"country":43,"year":13,"amount":14,"abstract":867},"cordis-european-research-council-award-862304","Unlocking the hidden information in char to create a new quantitative toolkit for use in forensic fire investigations","THE UNIVERSITY OF EXETER","Fire Investigations are undertaken to determine the origin and cause of fires in housing or commercial properties, to identify whether there may be a need for criminal investigation, to provide information on financial loss and in the case of loss of life to design protocols to protect society. Charring is one of the most obvious products of fire and fire investigators have long attempted to utilise patterns of charring to determine fire origin and cause. However, these have often had to rely on",{"id":869,"funder":7,"programme":8,"title":870,"piName":10,"institution":798,"country":117,"year":13,"amount":14,"abstract":871},"cordis-european-research-council-award-862517","InP Membrane on Silicon technology for a broad range of applications","Photonic technologies are key enablers for high-speed, on-demand communications, precision sensors, imaging and metrology. Industry roadmapping initiatives are now showing a clear and pressing need for miniaturising photonics solutions across market segments with sustained improvements in energy-efficiency, precision and performance. Photonic integration can meet these challenges, and has been convincingly demonstrated in fiber optic systems, but there is an absence of chip scale solutions for c",{"id":873,"funder":7,"programme":8,"title":874,"piName":10,"institution":444,"country":117,"year":13,"amount":10,"abstract":875},"cordis-european-research-council-award-841112","Proof-of-Concept of a nanobody targeting Osteopontin to inhibit colorectal cancer development","In this ERC Proof-of-Concept project, we aim to demonstrate the technical and commercial feasibility of a nanobody to target Osteopontin (OPN) for (co)treatment of colorectal cancer (CRC). This proposed project builds further upon recent findings as part of the ERC CRCStemCellDynamics project, in which we showed that OPN plays an important role in clonal expansion and cancer stem cell functionality. CRC accounts for ~10% of all cancers worldwide and forms a heavy financial burden for the EU heal",{"id":877,"funder":7,"programme":8,"title":878,"piName":10,"institution":402,"country":60,"year":13,"amount":14,"abstract":879},"cordis-european-research-council-award-840446","Commercial feasibility of an integrated soft robotic system for industrial handling","Picking and placing objects that are orderly presented to a robot is a task that can be easily performed by current robots. However, grasping and manipulating objects randomly placed in an unstructured environment remains one of the hardest challenges for robots. Examples of complex picking industrial applications include (i) bin picking for part feeding, (ii) raw food handling and (iii) waste sorting for recycling. Within the SoftHandler ERC Proof of Concept project, we propose to develop new i",{"id":881,"funder":7,"programme":8,"title":882,"piName":10,"institution":241,"country":43,"year":13,"amount":14,"abstract":883},"cordis-european-research-council-award-875698","Protecting wind-turbine leading edges with nanoengineered superhydrophobic urethane coatings","Wind energy is a vital component in meeting EU’s the Strategic Energy Technology (SET) plan and Europe’s ambition to become number one producer of renewables. Reducing operation and maintenance (O&M) costs are of paramount importance. The most serious problem affecting the wind industry is water erosion of the turbine blades. The blade leading edges are most susceptible, particularly in offshore turbines that are often battered by the water hammering mechanism of rain and seawater splash impact,",176,{"programme":8,"total":886,"withPiName":887,"firstYear":888,"lastYear":889,"countryCount":890,"perYear":891,"topInstitutions":929,"topCountries":997},2347,7,2014,2027,31,[892,894,897,899,902,905,906,909,912,915,918,921,924,927],{"year":888,"count":893},13,{"year":895,"count":896},2015,142,{"year":898,"count":896},2016,{"year":900,"count":901},2017,200,{"year":903,"count":904},2018,160,{"year":13,"count":884},{"year":907,"count":908},2020,174,{"year":910,"count":911},2021,120,{"year":913,"count":914},2022,198,{"year":916,"count":917},2023,231,{"year":919,"count":920},2024,237,{"year":922,"count":923},2025,265,{"year":925,"count":926},2026,264,{"year":889,"count":928},25,[930,933,936,939,942,945,948,951,954,956,958,961,964,967,969,972,975,977,980,982,984,986,989,992,994],{"name":931,"count":932},"Centre National de la Recherche Scientifique CNRS",84,{"name":934,"count":935},"Weizmann Institute of Science",65,{"name":937,"count":938},"Technion - Israel Institute of Technology",43,{"name":940,"count":941},"The Chancellor Masters and Scholars of the University of Cambridge",42,{"name":943,"count":944},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",41,{"name":946,"count":947},"Fondazione Istituto Italiano di Tecnologia",34,{"name":949,"count":950},"Tel Aviv University",33,{"name":952,"count":953},"Imperial College of Science Technology and Medicine",32,{"name":955,"count":953},"Politecnico di Milano",{"name":957,"count":890},"Institut National de la Sante Et de la Recherche Medicale",{"name":959,"count":960},"Ecole Polytechnique Federale de Lausanne",30,{"name":962,"count":963},"Universiteit Twente",29,{"name":965,"count":966},"The Hebrew University of Jerusalem",28,{"name":968,"count":966},"Universiteit Gent",{"name":970,"count":971},"The Chancellor, Masters and Scholars of the University of Oxford",27,{"name":973,"count":974},"Danmarks Tekniske Universitet",24,{"name":976,"count":974},"Vib Vzw",{"name":978,"count":979},"Katholieke Universiteit Leuven",23,{"name":981,"count":979},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",{"name":983,"count":979},"Technische Universitaet Muenchen",{"name":985,"count":979},"Technische Universiteit Delft",{"name":987,"count":988},"The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undivided Trinity of Queen Elizabeth Near Dublin",22,{"name":990,"count":991},"Technische Universiteit Eindhoven",21,{"name":993,"count":991},"Universiteit Leiden",{"name":995,"count":996},"Eidgenoessische Technische Hochschule Zuerich",20,[998,1000,1002,1004,1006,1008,1010,1012,1014,1016,1019,1021,1024,1026,1028,1030,1031,1034,1037,1039,1042,1044,1047,1049,1051],{"name":25,"count":999},299,{"name":37,"count":1001},273,{"name":43,"count":1003},261,{"name":117,"count":1005},254,{"name":60,"count":1007},221,{"name":12,"count":1009},215,{"name":128,"count":1011},191,{"name":145,"count":1013},109,{"name":134,"count":1015},85,{"name":1017,"count":1018},"SE",72,{"name":334,"count":1020},62,{"name":1022,"count":1023},"DK",50,{"name":288,"count":1025},48,{"name":158,"count":1027},47,{"name":413,"count":1029},40,{"name":205,"count":996},{"name":1032,"count":1033},"TR",19,{"name":1035,"count":1036},"NO",17,{"name":263,"count":1038},12,{"name":1040,"count":1041},"CZ",11,{"name":211,"count":1043},10,{"name":1045,"count":1046},"PL",8,{"name":1048,"count":1046},"SI",{"name":514,"count":1050},5,{"name":1052,"count":1053},"HR",2]