[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-proof-of-concept-2020":3,"awarded-stats-erc-proof-of-concept":857},{"awarded":4,"total":856},[5,16,20,26,32,38,44,48,52,56,61,66,72,77,81,86,91,96,101,107,112,118,123,128,133,139,144,150,156,161,166,171,176,180,185,190,195,200,205,210,215,220,225,229,235,241,246,252,257,261,266,272,277,282,287,292,297,302,307,312,316,322,326,330,334,338,342,346,350,355,360,365,370,375,380,385,390,395,400,405,409,414,419,424,428,434,439,444,448,454,459,464,469,474,479,484,489,493,497,502,507,512,517,523,528,533,538,543,548,553,558,562,566,571,575,579,583,587,591,595,599,604,609,614,619,623,628,633,639,644,648,652,656,661,666,671,677,682,687,692,696,701,705,710,714,718,723,728,734,739,743,748,753,758,762,767,771,777,782,787,791,795,800,805,809,814,820,824,829,834,838,842,846,851],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-957500","European Research Council","ERC Proof of Concept","Commercial feasibility of a quantitative ultrasound medical device: a patient-specific decision support system for the estimation of dental implant stability",null,"CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","FR",2020,"€150,000","Dental implants are widely used to replace missing teeth, with more than 4 000 000 implant surgery per year in Europe. Failures still occur because of a bad timing in the implant loading with the prosthesis, inducing pain and increased costs for dental surgeons. Although implant primary and secondary stability is the main determinant of the implant success, it remains difficult to be assessed in clinical practice. OsseoWave is based on the results obtained in the ERC CoG project Boneimplant and ",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":19},"cordis-european-research-council-award-875555","A cell separation microfabricated platform for cell migration and invasion assays","Cell migration is essential for tissue development, homeostasis, tumor progression, including the responses to wounds and inflammation. Cell interactions with their microenvironment affect many cellular functions such as spreading, migration and even differentiation. These interactions can be studied by incorporating micro- and nanotechnology-related tools. The design of substrates based on these technologies offers new possibilities to probe the cellular responses to changes in their physical e",{"id":21,"funder":7,"programme":8,"title":22,"piName":10,"institution":23,"country":24,"year":13,"amount":14,"abstract":25},"cordis-european-research-council-award-963914","Printing personalised medicines on demand","UNIVERSITY OF STUTTGART","DE","Methods of pharmaceutical manufacturing are likely to change dramatically over the coming years. Driven by the knowledge and technology that is already available in other sectors, the processing of drugs into dosage units can be transformed into a “pharmacy-on-demand” process that allows individual dosing, based on criteria relevant for the effective use of the drug in an individual patient. One approach to achieve “pharmacy-on-demand” is the use of inkjet printing technology to deliver an exact",{"id":27,"funder":7,"programme":8,"title":28,"piName":10,"institution":29,"country":30,"year":13,"amount":14,"abstract":31},"cordis-european-research-council-award-874964","Industrial Manufacturing Process for A high temperature superconducting Coated conductors Technology","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","ES","Coated conductors (CCs), known as the second generation of high temperature superconductors (2G-HTS), have triggered broad and fruitful R&D efforts to ensure industrial scalability and enable wide market adoption. Major challenges currently limit the practical use of HTS conductors. First, the high cost \u002F performance ratio imposed by the fabrication methods of kilometre-lengths epitaxial YBCO films that work at too low growth rates limits CC manufacturing throughput. Second, the low throughput i",{"id":33,"funder":7,"programme":8,"title":34,"piName":10,"institution":35,"country":36,"year":13,"amount":14,"abstract":37},"cordis-european-research-council-award-957516","A Soft Bioelectric Implant from Droplet Networks","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","UK","The goal of BIOELECTRIC is to fabricate and validate robust, durable and biocompatible soft bioelectric implants (SBI) that deliver ionic therapeutics. Fundamental science derived from our ERC Advanced Grant SYNTISU has generated a functional laboratory version of such an implant, but it is extremely fragile. Robustness and durability will be addressed by using advanced hydrogels to build the framework of the SBI and selected block copolymers to improve the performance of the essential membranes",{"id":39,"funder":7,"programme":8,"title":40,"piName":10,"institution":41,"country":42,"year":13,"amount":14,"abstract":43},"cordis-european-research-council-award-963933","Exfoliated black phosphorus for biomedical applications","CONSIGLIO NAZIONALE DELLE RICERCHE","IT","Since its discovery in 2014, bidimensional black phosphorus has raised a great scientific attention due to its unique structure and several exceptional attributes, such as peculiar optical and mechanical properties, excellent biocompatibility and biodegradation, which make it particularly attractive for biomedical applications. Our studies performed during ERC-Advanced Grant (2015-2019) “Phosphorene functionalization: a new platform for advanced multifunctional materials - PHOSFUN” demonstrated ",{"id":45,"funder":7,"programme":8,"title":46,"piName":10,"institution":41,"country":42,"year":13,"amount":14,"abstract":47},"cordis-european-research-council-award-899315","THz imaging technology for public security","The objectives of TERASEC project entail the activities aimed at pre-commercial validation of the technological performances and market potential of a novel device for the detection of security threats, such as weapons, explosives, drugs etc..The functionality of TERASEC is enabled through combination of superconducting and ferromagnetic materials that delivers frequency selective THz sensors showing unprecedented sensitivity (single-photon resolution), fast response time, high dynamic range, an",{"id":49,"funder":7,"programme":8,"title":50,"piName":10,"institution":35,"country":36,"year":13,"amount":14,"abstract":51},"cordis-european-research-council-award-875255","Real-time economic statistics tool for measuring the online gig economy","It is widely recognized both in the research literature as well as among policymakers that existing economic statistics are not well suited to measuring work that is transacted entirely digitally via websites and apps (the so-called online gig economy). To address this problem, as part of the ERC-funded research project iLABOUR, we have developed the Online Labour Index (OLI), an online gig economy equivalent of conventional labour market statistics. The OLI has already had major international s",{"id":53,"funder":7,"programme":8,"title":54,"piName":10,"institution":29,"country":30,"year":13,"amount":14,"abstract":55},"cordis-european-research-council-award-862121","Self-Powered Skin Patch for Cystic Fibrosis Diagnosis","Cystic fibrosis (CF) is a genetic autosomal recessive disease, which induces mutations on a conductance transmembrane regulator protein (CFTR) that controls the exocrine system responsible or producing saliva, sweat, tears and mucus. The protein malfunction affects severely the lungs and digestive system. Patients with CF present also higher chloride contents in sweat than healthy subjects, so chloride testing in sweat has become the gold standard test for CF confirmation after new-born screenin",{"id":57,"funder":7,"programme":8,"title":58,"piName":10,"institution":59,"country":12,"year":13,"amount":14,"abstract":60},"cordis-european-research-council-award-899835","Validation of a novel antiviral drug candidate against influenza","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","With 3 to 5 million severe cases and up to 650,000 deaths per year worldwide, influenza viruses are not only major human pathogens, they are also a heavy economic burden to our societies. In addition, influenza pandemics can occur at any time with potential devastating effects in terms of lives and costs. Solutions to prevent infection, to treat severe influenza cases and to respond to a severe pandemic are currently extremely limited and rely on vaccination and on only few approved molecules. A",{"id":62,"funder":7,"programme":8,"title":63,"piName":10,"institution":64,"country":24,"year":13,"amount":14,"abstract":65},"cordis-european-research-council-award-899260","Control-oriented PD state modelling and estimation for precision medicine","TECHNISCHE UNIVERSITAET MUENCHEN","Despite the fact that there has been some progress in developing methods for estimating Parkinson’s disease (PD) symptoms using wearable sensors, these technologies have not sufficiently penetrated the market due to the usability of the system and its cost; existing technologies are constrained by specific hardware requirements or user activities, therefore aversively affecting the cost and usability of the technologies, respectively. Thus, Con-PDmode delivers a software prototype for control-or",{"id":67,"funder":7,"programme":8,"title":68,"piName":10,"institution":69,"country":70,"year":13,"amount":14,"abstract":71},"cordis-european-research-council-award-899930","Practical Quantum Technology Education for Industry","AARHUS UNIVERSITET","DK","The onset of the “second quantum revolution” has catapulted quantum technologies from basement laboratories into the commercial sector. This has led to a growing need for an associated quantum-savvy workforce. Not all of these workers need to have formal post-secondary education in physics, as this revolution needs, for example, mechanical engineers and business managers as much as it needs quantum physicists. However, some quantum competence is immeasurably helpful when working within the field",{"id":73,"funder":7,"programme":8,"title":74,"piName":10,"institution":75,"country":36,"year":13,"amount":14,"abstract":76},"cordis-european-research-council-award-875525","High throughput multiplexed trace-analyte screening for diagnostics applications","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","There is an enormous need for analytical methods that can achieve simultaneous detection of multiple soluble proteins in complex biological fluids. A technology that can achieve this holds the promise of far-reaching impact in multiple healthcare grand challenges ranging from neurodegenerative disease to several major cancers. This project aims to develop a multiplexed label-free detection of soluble proteins and miRNA in biofluids. The proposed method is universal and if successful this pilot w",{"id":78,"funder":7,"programme":8,"title":79,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":80},"cordis-european-research-council-award-899537","Cancer Organoids Multiplexed Screening in Microfluidic Textile chips","The development of precision and personalized medicine, notably in cancer, leads to an explosion in the cost of research, clinical trials, diagnosis and treatment. It calls for a change of paradigm in cell-based personalized models, allowing-high throughput screening of large panels of drugs at low cost and on minute samples.  We invented in ERCadg CellO a new technology “Free-Flow Textile Chips” (FFTC) proving a solution to the above problem. It allows the production of high-resolution complex ",{"id":82,"funder":7,"programme":8,"title":83,"piName":10,"institution":84,"country":36,"year":13,"amount":14,"abstract":85},"cordis-european-research-council-award-872082","The development and validation of a hand-based stroke rehabilitation product","THE UNIVERSITY OF BIRMINGHAM","The ERC proThe ERC project (MotMotLearn), underlying ImpHandRehab, aims to develop reward-based interventions that optimise motor learning in stroke patients suffering upperlimb impairments. MotMotLearn has shown that if reward-based feedback is combined with a distracting environment learning is robust to interference and resistant to forgetting; important components for a successful rehabilitation intervention. However, this work has highlighted several technical limitations which restrict our",{"id":87,"funder":7,"programme":8,"title":88,"piName":10,"institution":89,"country":42,"year":13,"amount":14,"abstract":90},"cordis-european-research-council-award-875429","INNOVATIVE AND EFFICIENT SOLUTION FOR PRODUCTION IN MICROALGAE OF EASILY EXTRACTIBLE AND HIGHLY PURE ASTAXANTHIN FOR ADDED-VALUE PRODUCTS","UNIVERSITA DEGLI STUDI DI VERONA","Astaxanthin is a carotenoid with a high commercial value. Its high anti-oxidant activity makes Astaxanthin being used as a food\u002Ffeed supplements, in cosmetics, and in nutraceutics. Microalgae are the main primary sources of Astaxanthin, being produced at industrial level mainly by cultivation of the green alga Haematococcus pluvialis with high costs for cultivation and extraction, hindering its market.In the ERC-StG-SOLENALGAE project the investigation of the role of carotenoids in photoprotecti",{"id":92,"funder":7,"programme":8,"title":93,"piName":10,"institution":94,"country":30,"year":13,"amount":14,"abstract":95},"cordis-european-research-council-award-899773","Manufacture of nanostructured Conjugated Porous Polymers for energy applications","Fundacion IMDEA Energia","The world energy demand is continuously growing due to the increase of population. This has triggered the need of new technologies that allow the sustainability of the planet. In this sense, the search of novel materials that can be introduced in these new technological approaches is mandatory. In NanoCPPs project, the design, synthesis and scale up of nanoparticles based on Conjugated Porous Polymers (CPPs)  will be performed.  Advanced techniques will be applied to obtain processable CPPs as c",{"id":97,"funder":7,"programme":8,"title":98,"piName":10,"institution":99,"country":42,"year":13,"amount":14,"abstract":100},"cordis-european-research-council-award-899912","Pre-commercialization of stable and compact lasers for atom based quantum technologies","ISTITUTO NAZIONALE DI RICERCA METROLOGICA","Optical transitions in atoms and ions are used in precise interferometry, quantum computation (QC) and accurate clock applications, and the research in these fields has led the birth of a laser spectroscopy industry. Currently, this industry is growing, and smaller lasers are already finding their way into exciting transportable applications, such as rockets. QC possesses extensive market potential, and is expected to surpass the $2 billion mark over the next five years. QC industry is a forerun",{"id":102,"funder":7,"programme":8,"title":103,"piName":10,"institution":104,"country":105,"year":13,"amount":14,"abstract":106},"cordis-european-research-council-award-899947","CIRCULATING TUMOR DNA AS AN EPIGENETIC BIOMARKER FOR TUMOR RESPONSE","VIB VZW","BE","Tumors are characterized by a disorganized vasculature, leading to profound levels of hypoxia. Normalizing the blood vessel formation (angiogenesis) in tumors has therefore become an attractive therapeutic strategy, leading to the development of approved drugs that inhibit major angiogenic pathways. Resistance however restricts the success of these anti-angiogenic drugs in some patients. There is thus a great clinical need for readily accessible markers that serve as reliably predictive biomarke",{"id":108,"funder":7,"programme":8,"title":109,"piName":10,"institution":110,"country":24,"year":13,"amount":14,"abstract":111},"cordis-european-research-council-award-899861","Beam-forming OLED with nanostructured fluorescence layer","CHRISTIAN-ALBRECHTS-UNIVERSITAET  ZU KIEL","The emergence of the Internet of Things (IoT), Industry 4.0 as well as the drive for point-of-care biomedical diagnostics is accompanied by a strong need for measuring physical, chemical and biomedical status data in real time with cost-efficient and low-maintenance sensors. With optical measurement techniques being widely employed, miniaturized optical sensor devices are highly promising. Light emitting diodes based on organic semiconductor materials (OLEDs) are experiencing a rapid market grow",{"id":113,"funder":7,"programme":8,"title":114,"piName":10,"institution":115,"country":116,"year":13,"amount":14,"abstract":117},"cordis-european-research-council-award-875668","Precision Medicine via Diagnostic Enzyme Activity Testing","HELSINGIN YLIOPISTO","FI","PreMeDosE aims to ascertain the technical and commercial viability of a novel cytochrome P450 (CYP) enzyme activity assay, to enable truly personalised drug dosing for the first time. The CYP enzymes are responsible for the elimination of the majority of therapeutic drugs from the body. However, inter-individual variation in CYP activity leads to personal differences in drug elimination kinetics, both toxic accumulation (too slow elimination) and loss of therapeutic efficacy (too rapid eliminati",{"id":119,"funder":7,"programme":8,"title":120,"piName":10,"institution":121,"country":70,"year":13,"amount":14,"abstract":122},"cordis-european-research-council-award-875344","Therapeutic Drug Monitoring with Smartphone-integrated Surface Enhanced Raman Spectroscopy","DANMARKS TEKNISKE UNIVERSITET","Therapeutic drug monitoring (TDM) is an essential tool for measuring the circulating concentration of specific narrow therapeutic drugs at designated intervals, in order to maximise the efficacy of the drug and avoid toxicity and adverse drug reactions. TDM is currently available only in central laboratories or large hospitals, and several barriers prevent its wide implementation in routine clinical practice. First, current technologies used for TDM (e.g. high-performance liquid chromatography –",{"id":124,"funder":7,"programme":8,"title":125,"piName":10,"institution":126,"country":12,"year":13,"amount":14,"abstract":127},"cordis-european-research-council-award-875102","Generation of therapeutic antibodies targeting type 2 Innate Lymphoid cells in asthma","UNIVERSITE D'AIX MARSEILLE","We are proposing to target Innate Lymphoid Cells 2 (ILC2s), a subset that has been frequently implicated in inflammatory diseases, such as severe asthma. ILC2s are major players in allergic asthma and are abundantly present as tissue resident cells in the lung, both in human and mouse. Strikingly, the induction of allergic asthma in a mouse model deficient in ILC2s is abolished. In addition, the transfer of ILC2s back in the same mouse recapitulates the pathology. Mechanistically, activated ILC2",{"id":129,"funder":7,"programme":8,"title":130,"piName":10,"institution":131,"country":42,"year":13,"amount":14,"abstract":132},"cordis-european-research-council-award-899727","Deacetylase inhibitors for autism spectrum disorders: an integrated preclinical validation pipeline in brain organoids and in vivo models","UNIVERSITA DEGLI STUDI DI MILANO","ASD is a very prevalent neurodevelopmental condition affecting more than 1% individuals, and represents a major unmet medical need since no effective treatment is available. Despite the phenotypic convergence of its core symptoms (impaired language, restriction in sociability and stereotypies, invariably coupled to anxiety and often associated to varying degrees of intellectual disability), ASD is genetically highly heterogeneous, with hundreds of bona fide causative genetic lesions. This geneti",{"id":134,"funder":7,"programme":8,"title":135,"piName":10,"institution":136,"country":137,"year":13,"amount":14,"abstract":138},"cordis-european-research-council-award-899766","Compositions for use in the treatment of insulin deficiency conditions","UNIVERSITE DE GENEVE","CH","Tens of millions suffer from insulin deficiency (ID); a condition caused by pancreatic β-cell loss. If untreated, ID is a lethal catabolic disease characterized by hyperglycemia. Thus, the focus of ID research and drug development has been mainly on improving strategies to lower hyperglycemia without causing life-threatening hypoglycemia. However, in addition to increased circulating glucose level β-cell loss leads to several “other defects”, some of which (e.g. severe hyperketonemia and ketoaci",{"id":140,"funder":7,"programme":8,"title":141,"piName":10,"institution":142,"country":105,"year":13,"amount":14,"abstract":143},"cordis-european-research-council-award-861913","Pannexin1 nanobodies for the clinical treatment of liver disease","VRIJE UNIVERSITEIT BRUSSEL","Pannexin1 (Panx1) channels mediate the exchange of biochemical messengers between the cytosol of a cell and its extracellular environment. This type of cellular communication underlies cell death and inflammation, both which are associated with a plethora of diseases. Closing pannexin channels therefore seems an interesting therapeutic strategy. In this respect, the ERC Starting Grant project CONNECT has demonstrated that peptide-based inhibition of Panx1 channels counteracts the manifestation o",{"id":145,"funder":7,"programme":8,"title":146,"piName":10,"institution":147,"country":148,"year":13,"amount":14,"abstract":149},"cordis-european-research-council-award-899856","A digestion and absorption mimicking bench-top intestinal model","UPPSALA UNIVERSITET","SE","Oral administration of drugs is the method of choice for patients and healthcare providers alike because it is both convenient and inexpensive. About 70-90% of the drug candidates have low solubility in the water-based environment of the gut, and therefore a number of strategies have been developed to increase drug solubility, one of these being Lipid-Based Formulations (LBFs). Currently, less than 4% of commercial drug products are LBFs due, in large part, to the difficulty of characterisation ",{"id":151,"funder":7,"programme":8,"title":152,"piName":10,"institution":153,"country":154,"year":13,"amount":14,"abstract":155},"cordis-european-research-council-award-899477","Commercialization of open vesicles to fuel downstream reaction networks","RIJKSUNIVERSITEIT GRONINGEN","NL","Numerous biotechnological processes require Adenosine-5'-triphosphate (ATP) as a form of free energy to drive endergonic reactions. The bottleneck is that after some time the reaction stops due to adenosine diphosphate (ADP) build up and the depletion of energy reserves. In living cells, functional and sustainable out-of-equilibrium networks exist. Scientists have tried to mimic such autonomous systems without the need for external interaction, or fuel supply. Real success hasn’t been reported. ",{"id":157,"funder":7,"programme":8,"title":158,"piName":10,"institution":159,"country":30,"year":13,"amount":14,"abstract":160},"cordis-european-research-council-award-899961","Computational Design Solutions for Touch Interfaces","UNIVERSIDAD REY JUAN CARLOS","Virtual reality (VR) and Human-computer interaction (HCI) are becoming available industrial technologies. However, to date, they miss support for touch interaction or haptics. While there are attempts to introduce various tactile\u002Fhaptic interfaces in the market, these interfaces hardly take off, arguably because of technical barriers to integrate them and develop convincing applications. The *feelware* project will break these barriers and will ease the adoption of tactile\u002Fhaptic interfaces in V",{"id":162,"funder":7,"programme":8,"title":163,"piName":10,"institution":164,"country":154,"year":13,"amount":14,"abstract":165},"cordis-european-research-council-award-899422","Transcriptional targeting of pacemaker and conduction system gene therapy","ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM","The problem: Ageing and age-related diseases cause degeneration of the cardiac conduction system (CCS) that creates and conducts the electrical impulse which drives the heart beat (pacing). The resulting slow heart rate (bradycardia) necessitates electronic pacemaker implantation in 500,000 patients yearly in Europe (direct costs of €3.4 billion). This current state-of-the-art treatment has significant limitations (dangerous complications, reduced quality-of-life) that, stemming from its design,",{"id":167,"funder":7,"programme":8,"title":168,"piName":10,"institution":169,"country":36,"year":13,"amount":14,"abstract":170},"cordis-european-research-council-award-963937","A modular sensing and imaging toolkit for the early diagnosis of prostate cancer employing lab-on-the-chip methodologies","UNIVERSITY OF BATH","This Proof-of-concept project will focus on the innovative exploitation of new diagnostic sensor prototypes which will tackle the early diagnosis of prostate cancer (PCa), one of the greatest concerns for ageing men worldwide. The development of fast and reliable methods for detecting PCa by electrochemical or optical biosensing will address the unmet need for an early diagnosis and for monitoring non-invasively the PCa evolution post-diagnosis. Current PCa screening methods detect the prostate-",{"id":172,"funder":7,"programme":8,"title":173,"piName":10,"institution":174,"country":42,"year":13,"amount":14,"abstract":175},"cordis-european-research-council-award-875268","Providing RObust high TECHnology Tags based on linear carbon nanostructures","POLITECNICO DI MILANO","In a global world, identity frauds are an important issue to ensure security throughout the EU and its member states. Improved protection systems have made more difficult counterfeiting ID documents, but all currently adopted solutions are potentially subject to fraud.This is the reason why radically novel security strategies are required to ensure security for the next decades.The PROTECHT project (Providing RObust high TECHnology Tags based on linear carbon structures) aims at developing advan",{"id":177,"funder":7,"programme":8,"title":178,"piName":10,"institution":174,"country":42,"year":13,"amount":14,"abstract":179},"cordis-european-research-council-award-899431","Organ-on-a-chip Drug screenIng device to tArget braiN diseAse","The commitment to drug development for brain pathologies is experiencing a fast rate decreasing, a critical situation in a worldwide scenario where the number of patients affected by brain pathologies like Alzheimer’s (AD) or Parkinson’s (PD) disease are expected to greatly increase in the next decades. One critical point is that the development of new drugs is a three-phase process that currently requires 10-15 years and investment of 1-3 billion euros against a failure rate of about 99.6% for ",{"id":181,"funder":7,"programme":8,"title":182,"piName":10,"institution":183,"country":137,"year":13,"amount":14,"abstract":184},"cordis-european-research-council-award-957545","Polarization tracking in situ","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","The technology for the growth of thin oxide films has reached the same level of atomic control as in the case ofsemiconductors. Yet, in contrast to semiconductors, oxides exhibit novel phases and functionalities like magnetic or electricorder or dramatic changes of electrical resistance. One such functionality is the spontaneous formation of an electricpolarization, called ferroelectricity, that is considered as basis for novel types of smart devices or energy-efficient functionalcomponents in C",{"id":186,"funder":7,"programme":8,"title":187,"piName":10,"institution":188,"country":42,"year":13,"amount":14,"abstract":189},"cordis-european-research-council-award-899770","Monoamine oxidase B inhibitors as novel drugs targeting NLRP3 inflammasome","UNIVERSITA DEGLI STUDI DI PADOVA","Although the number of anti-inflammatory drugs has increased during the past decade, there is still an urgent need to develop novel alternatives that overcome limitations of current treatments. The most used therapies, such as non-steroidal anti-inflammatory drugs, non-analgesic anti-inflammatory drugs or colchicine, often present severe side-effects. In addition, in recent years biologicals have appeared, but they are extremely expensive. Therefore, novel therapeutic approaches with lower toxic",{"id":191,"funder":7,"programme":8,"title":192,"piName":10,"institution":193,"country":154,"year":13,"amount":14,"abstract":194},"cordis-european-research-council-award-875604","Getting ready to treat human patients with nanobody-targeted photodynamic therapy","UNIVERSITEIT UTRECHT","Unfortunately, current cancer therapies often fail to cure patients, or are associated with severe side effects. Ideally, a therapy should locally eradicate cancer cells without damaging healthy tissue and should induce long term protection through activation of the immune system. Photodynamic therapy (PDT) is a treatment approach which can do both, through the local light activation of photosensitizers. However, current photosensitizers lack cancer specificity, which limits therapeutic efficacy",{"id":196,"funder":7,"programme":8,"title":197,"piName":10,"institution":198,"country":42,"year":13,"amount":14,"abstract":199},"cordis-european-research-council-award-899838","Commercialization of catalytic enhancers targeting IDO1 for multiple sclerosis","UNIVERSITA DEGLI STUDI DI PERUGIA","ENHANCIDO will assess the commercial and technical feasibility of novel immune tolerance-inducing small molecules as superior treatments for multiple sclerosis (MS). MS is a chronic neurodegenerative disease affecting 2.3 million people worldwide. 85% of MS cases belong to the relapsing-remitting subtype (RRMS) characterised by bouts of recurring and debilitating relapses followed by unstoppable loss of neurological functions. Unfortunately, current treatments for RRMS are ineffective, poorly to",{"id":201,"funder":7,"programme":8,"title":202,"piName":10,"institution":203,"country":36,"year":13,"amount":14,"abstract":204},"cordis-european-research-council-award-963998","MEsmerizing Thermal Annihilation Method to Obliterate Radicals PHOtoinduced in Substances for Increasing Spin polarization","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","The use of hyperpolarized 13C magnetic resonance (HP 13C MR) to perform radiological scans can provide novel information for medical diagnostic purpose. HP 13C-molecules are injected intravenously and allow performing metabolic imaging, highlighting diseased tissues and treatment response. HP 13C-urea is also a potential nontoxic alternative to gadolinium-based contrast agents for MRI. Hyperpolarization aims at dramatically increasing the 13C MR signal by dynamic nuclear polarization (DNP), whic",{"id":206,"funder":7,"programme":8,"title":207,"piName":10,"institution":208,"country":36,"year":13,"amount":14,"abstract":209},"cordis-european-research-council-award-957463","Levitated particles as the heart of miniaturized sensing technologies","KING'S COLLEGE LONDON","The phrase “no moving parts” is misleading; mechanical oscillators are the beating heart of modern technology. Whether it’s the vibration of quartz crystals setting the pace of computation, or surface acoustic wave devices amplifying signals in smartphones, mechanical oscillators are truly ubiquitous.Micro-Electromechanical Systems, or MEMS devices, dominate research into mechanical devices with technological applications. Due to their ability to be mass fabricated, they have found applications ",{"id":211,"funder":7,"programme":8,"title":212,"piName":10,"institution":213,"country":154,"year":13,"amount":14,"abstract":214},"cordis-european-research-council-award-956875","An ex vivo platform to screen drug effects on bone","TECHNISCHE UNIVERSITEIT EINDHOVEN","Drug development remains a long and costly process with low success rates in clinical trials. While a majority of cell-based compound screenings are still based on 2D experiments, compelling evidence suggests that 3D culture technologies will accommodate for a better precision in drug discovery. On the other hand, such screening cultures are particularly challenging in terms of 3D visualization. In the BoneScreen project, we propose to develop a high content screening (HCS) platform capable of i",{"id":216,"funder":7,"programme":8,"title":217,"piName":10,"institution":218,"country":24,"year":13,"amount":14,"abstract":219},"cordis-european-research-council-award-957643","Generating monoclonal antibodies that selectively and specifically recognize epitranscriptomic modifications.","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","Epitranscriptomic modifications constitute specific marks in mRNA that regulate gene expression. Identification ofepitranscriptomic modifications requires next generation sequencing analyses and specific validation, processes that are cumbersome and time consuming. Furthermore, while some modifications are straightforward to identify, as they cause specific base changes (like RNAediting), most are only detectable either through chemical means (requiring large quantities of material) or by immuno",{"id":221,"funder":7,"programme":8,"title":222,"piName":10,"institution":223,"country":24,"year":13,"amount":14,"abstract":224},"cordis-european-research-council-award-899609","Disposable well-plate inserts and perfusion chambers for easy-to-use and generic microchannel creation in 3D tissue culture","UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT","Functional 3D tissue models could replace animal experiments and significantly reduce the cost of over 100 million € that pharmaceutical companies spend on failed drug development every year. The main bottleneck in the in vitro creation of 3D tissues is the need for perfusable vascularization in tissues bigger than 1 mm. So far, no generally applicable product exists for that purpose. This hampers advances in drug development as well as in research.Design2Flow will develop products, which overco",{"id":226,"funder":7,"programme":8,"title":227,"piName":10,"institution":203,"country":36,"year":13,"amount":14,"abstract":228},"cordis-european-research-council-award-957513","Perovskite Scintillators for X-Ray Imaging","X-ray imaging is a widely employed tool both for basic research and real-world applications such as security, food screening and medical imaging. However, X-rays are considered ionising radiation and can pose significant risks to humans if not carefully employed. Moreover, resolution is closely linked to radiation dose, which means that a limit is placed on the resolution achievable by an X-ray detector based on how well the detector’s active layer can respond to incident radiation. Currently, c",{"id":230,"funder":7,"programme":8,"title":231,"piName":10,"institution":232,"country":233,"year":13,"amount":14,"abstract":234},"cordis-european-research-council-award-899245","Upscaling of fluorographene chemistry for supercapacitor electrode material","UNIVERZITA PALACKEHO V OLOMOUCI","CZ","The world population is significantly increasing and its reliance on energy-based devices is higher than ever before. This leads to a continuous rise in global energy consumption. Considering that fossil fuel resources are strictly limited and have a detrimental effect on our environment, it is understandable that research focused on sustainable energy resources, coupled with suitable energy storage technologies, attracts an intense interest. In addition, the ever-growing number of electric bike",{"id":236,"funder":7,"programme":8,"title":237,"piName":10,"institution":238,"country":239,"year":13,"amount":14,"abstract":240},"cordis-european-research-council-award-957512","CAR-T cell therapy targeting carbohydrates in cancer","TEL AVIV UNIVERSITY","IL","Major limitations in current immunotherapy success are low antigenicity of targeting antigen and tumor heterogeneity. Hence there is an unmet need for novel antigen targets that could potentially be expressed on many tumor types. Cancer express aberrant cell surface glycosylation patterns compared to normal cells. These tumor-associated carbohydrate-neoantigens can be targeted for tumor cell killing by antibodies and cytotoxic immune cells. Sialic acids cover cell surface glycans and frequently ",{"id":242,"funder":7,"programme":8,"title":243,"piName":10,"institution":244,"country":154,"year":13,"amount":14,"abstract":245},"cordis-european-research-council-award-875709","Ruthenium-based photoactivated chemotherapy against eye cancer","UNIVERSITEIT LEIDEN","The Ru4EYE PoC proposal will develop the first pre-clinical evaluation of Ru-based PACT compounds in uveal melanoma (UM) model. UM is a rare malignancy of the eye. Although treatment against UM do exist, they do no always preserve vision or the eye, and often lead to patient death via metastasis to the liver. A better treatment that would save vision, the eye, and the patient, is looked after. UM appears as an appealing disease for photoactivated chemotherapy (PACT), a new form of phototherapy d",{"id":247,"funder":7,"programme":8,"title":248,"piName":10,"institution":249,"country":250,"year":13,"amount":14,"abstract":251},"cordis-european-research-council-award-899953","A 3D-bioprinting platform with exchangeable tailor-made print heads to engineer tissue surrogates","UNIVERSIDADE DO MINHO","PT","Three-dimensional (3D) bioprinting has been projected as one of the technologies with higher prospects to engineer tissue surrogates, which are i) an unquestionable demand for regenerative medicine and ii) an acknowledged upgrade of 2D in vitro cultures as reliable and predictive testing\u002Fscreening systems for pharma and cosmetic industries. Despite the important milestones achieved so far, bioprinting functional tissues surrogates has proved difficult. The biggest challenge still is the fabricat",{"id":253,"funder":7,"programme":8,"title":254,"piName":10,"institution":255,"country":239,"year":13,"amount":14,"abstract":256},"cordis-european-research-council-award-899366","Bidirectional flow filter: microfluidic device for separation of biomolecules","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","The analysis of extremely small samples is boosting the field of life and medical science, from basic research on single-cell systems, through point-of-care diagnostics, to forensic analysis. Despite great advances made on analytical techniques such as digital immunoassay, nanopore detection and next-generation sequencing, little progress has been made on low-volume sample preparation technologies, which are key for the success of such analytical techniques. To date, despite the availability of ",{"id":258,"funder":7,"programme":8,"title":259,"piName":10,"institution":153,"country":154,"year":13,"amount":14,"abstract":260},"cordis-european-research-council-award-875163","Photopharmacology: From Academia toward the Clinic.","''Photopharmacology: from academia toward the clinic'' aims at the development of our platform technology from an academically emerging field towards a technology which has proven clinical applicability. Within this project novel photopharmacological targets will be evaluated and investigated. Additionally, in vivo proof of concept will be generated to make our technology ready for further clinical validation.",{"id":262,"funder":7,"programme":8,"title":263,"piName":10,"institution":264,"country":42,"year":13,"amount":14,"abstract":265},"cordis-european-research-council-award-899661","HyperCube: Gram scale production of ferrite nanocubes and thermo-responsive polymer coated nanocubes for medical applications and further exploitation in other hyperthermia fields","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","This project aims at the scale up production, characterization, future commercialization and clinical translation of magnetic iron oxides nanocubes of high magnetic and structural quality and the design and production of an in-flow set up for the further functionalization of the nanocubes with a thermo-responsive (TR) polymer shell. The nanocubes and TR-nanocubes are aimed to be used primarily as heat mediators in magnetic hyperthermia (MH) and as heat-mediated drug agents for the delivery of ch",{"id":267,"funder":7,"programme":8,"title":268,"piName":10,"institution":269,"country":270,"year":13,"amount":14,"abstract":271},"cordis-european-research-council-award-957570","Demonstration of a Radar Enabled weArable platforM","UNIVERSITE DU LUXEMBOURG","LU","Sport research and procedures that aim to increase performance or assist recovery after an injury often require capture of athlete’s motion. However, implementing a motion capture system in routine practice takes significant effort. Capture volume, weather conditions, motion dynamics and athletes' timing (where timing defines coincide movements in relation to external factors) are the key parameters for outdoor sport activities (e.g. track and field or football), yet no available motion capture ",{"id":273,"funder":7,"programme":8,"title":274,"piName":10,"institution":275,"country":24,"year":13,"amount":14,"abstract":276},"cordis-european-research-council-award-957443","LONGSENSE - A novel biosensor for lncRNA","TECHNISCHE UNIVERSITAT DARMSTADT","The function of ribonucleic acid (RNA) was long thought to be only an intermediate product in the protein synthesis machinery, but this view changed since the biological significance of the non-coding protein fraction of RNA was discovered. More recently a still evolving class of RNAs with a length above 200 nucleotides, the long non-coding RNAs (lncRNA) came into the spotlight.  Up- or downregulation have been associated with human diseases, such as neurodegenerative and psychiatric diseases, c",{"id":278,"funder":7,"programme":8,"title":279,"piName":10,"institution":280,"country":250,"year":13,"amount":14,"abstract":281},"cordis-european-research-council-award-957585","Extracellular matrix derived products from human placenta to engineer bone microtissues for in vitro disease models.","UNIVERSIDADE DE AVEIRO","The aim of ‘AMNIOGEL’ is the development of human extracellular matrix (ECM) based materials, as radically innovative,highly versatile human-derived platforms for 3D cell culture, microtissue development and disease models establishment. Inparticular, we will develop 3D disease models that could be used as an enabling tool for personalized drug discovery,increasing our understanding of the mechanisms behind bone cancer.The proposed cutting-edge technology enables the culture of human cells in a ",{"id":283,"funder":7,"programme":8,"title":284,"piName":10,"institution":285,"country":148,"year":13,"amount":14,"abstract":286},"cordis-european-research-council-award-957495","Development of small molecule OGG1 Inhibitor and proof of concept in bleomycin-induced disease model of Inflammation and pulmonary Fibrosis","KAROLINSKA INSTITUTET","Fibrosis in response to tissue damage or persistent inflammation is a pathological hallmark of many chronic degenerative diseases whereIdiopathic Pulmonary Fibrosis (IPF) is one of the most severe diseases. IPF is a progressive condition with unknown etiology and a mediansurvival of three years from diagnosis. Current medical treatment is limited to slowing down the disease and thus there is still a high unmet medical need. OGG1 enzyme has a major role in DNA repair in conditions of oxidative st",{"id":288,"funder":7,"programme":8,"title":289,"piName":10,"institution":290,"country":154,"year":13,"amount":14,"abstract":291},"cordis-european-research-council-award-875272","Helping Children to Make the Best of their Transition to High School","STICHTING VU","Poor social experiences with peers, such as peer rejection or peer victimization, and with teachers, such as receiving low support or having conflictual relations with teachers during elementary school impede children’s self- and stress-regulation. The affected self- and stress-regulation places these children at risk of developing similar troublesome relations with teachers and peers after the transition to high school. We propose to develop a serious game named A.L.I.B.I. to help children make",{"id":293,"funder":7,"programme":8,"title":294,"piName":10,"institution":295,"country":36,"year":13,"amount":14,"abstract":296},"cordis-european-research-council-award-875692","Apollo: developing a powerful and easy to use platform for choice model estimation and application with full user-customisation","UNIVERSITY OF LEEDS","Mathematical models of human decision making are a widely used tool for advising policy makers and industry by making predictions of future demand for products and services. The reliability of the predictions depends on the robustness of the underlying mathematical models. A very active field of academic research is concerned with the refinement of existing model structures and the development of new approaches. Over the last two decades, fuelled by the availability of ever more powerful computi",{"id":298,"funder":7,"programme":8,"title":299,"piName":10,"institution":300,"country":116,"year":13,"amount":14,"abstract":301},"cordis-european-research-council-award-875658","Commercialization of 3D histopathological evaluation of osteoarthritis – new tools for therapy monitoring from preclinical testing to hospitals","OULUN YLIOPISTO","Osteoarthritis (OA) is the most common musculoskeletal disease. OA has significant socio-economic impact as it severely affects the quality of life, reduces productivity and carries higher risk of mortality. However, the development of new treatments for OA is painstakingly long and very challenging. There are many clinical OA drug trials that have ended in a failure.  In my ERC-StG project, we have developed 3D histopathological evaluation method of OA from micro-computed tomography (μCT). It a",{"id":303,"funder":7,"programme":8,"title":304,"piName":10,"institution":305,"country":36,"year":13,"amount":14,"abstract":306},"cordis-european-research-council-award-899840","Mole Gazer: Proof-of-concept study to improve early detection of melanoma using time-series analyses of evolution of naevi","UNIVERSITY OF SOUTHAMPTON","Early detection of melanoma improves survival. Individuals with multiple naevi (moles) are at an increased risk of developing melanoma, but sequential monitoring by dermatologists is time-consuming and inefficient. Artificial intelligence (AI) methods can potentially diagnose melanoma from single time-point lesion images, but a more clinically-relevant question is whether melanoma can be detected early, based on automated detection of changes in naevi using total body photography (TBP; high-reso",{"id":308,"funder":7,"programme":8,"title":309,"piName":10,"institution":310,"country":12,"year":13,"amount":14,"abstract":311},"cordis-european-research-council-award-899539","Computed tomography targets for efficient guidance of catheter ablation in ventricular tachycardia","UNIVERSITE DE BORDEAUX","Patients at risk of ventricular tachycardia (VT), the primary cause of sudden cardiac death, commonly undergo catheter ablation to cauterize the areas within myocardial scars responsible for arrythmias. However, the initial phase of the intervention devoted to identifying the ablation targets currently involves the intra-cardiac insertion of a mapping catheter characterized for being invasive, often inaccurate, and time-consuming. Pre-operative implementation of 3D cardiac imaging approaches to ",{"id":313,"funder":7,"programme":8,"title":314,"piName":10,"institution":142,"country":105,"year":13,"amount":14,"abstract":315},"cordis-european-research-council-award-875048","Valorization trajectory of a 3D particle image velocimetry instrument","Actual implementation of impactful applications for microfluidic devices in a commercial setting has been surprisingly limited so far. The cause can be to a great extent attributed to the main feature of microfluidic devices: their small dimensions. While miniaturized structures are essential in generating key functionalities, they are also ideal nucleation and anchor sites for solid material present in the liquid that flows through the channels, a phenomenon called fouling. This subsequently re",{"id":317,"funder":7,"programme":8,"title":318,"piName":10,"institution":319,"country":320,"year":13,"amount":14,"abstract":321},"cordis-european-research-council-award-899886","Transparent Aluminium Networks","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","IE","The aim of this PoC proposal is to determine the economic and technical feasibility of using electrospun polymer templates to fabricate mechanically robust, corrosion resistant transparent conductors (TC) on flexible substrates for display, lighting, solar cells and other applications where light transmission is critical to device operation.  This innovation exploits the use of inexpensive aluminium networks that surpass the performance of indium tin oxide (ITO) - the industry standard.  The bri",{"id":323,"funder":7,"programme":8,"title":324,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":325},"cordis-european-research-council-award-963890","NanoPrint: A novel nanometric additive manufacturing tool","Additive Manufacturing (AM) offers the opportunity to quickly design and make prototypes that would otherwise require multiple step processing (lithography, nanoimprint…). So far, two-photon polymerization is the leading technology for manufacturing micron sized objects with nanometric resolution. However, thise technique requires photosensitive material, that polymerizes through two-photon absorption, limiting the versatility of the the technology NanoPrint is a direct AM technique, offering re",{"id":327,"funder":7,"programme":8,"title":328,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":329},"cordis-european-research-council-award-899555","Fluorescent Molecules to see when and where Molecules Break during Mechanical Fatigue","Although elastomers are widely used in load-bearing engineering applications where lightweight and flexibility is essential, they are typically designed thicker than they need to be, due to a poor prediction of their lifetime in use. The loss of flexibility and extensibility results from individual covalent bond scission in the bulk of the material. When the extent of bond scission increases or localizes in specific spots, the rubber becomes brittle and can break catastrophically, potentially ca",{"id":331,"funder":7,"programme":8,"title":332,"piName":10,"institution":208,"country":36,"year":13,"amount":14,"abstract":333},"cordis-european-research-council-award-957532","Maximizing the Therapeutic Potential of Music through Tailored Therapy with Physiological Feedback in Cardiovascular Disease","Cardiovascular disease is the world’s leading cause of death, and hypertension is its foremost medical risk factor. Reducing blood pressure in hypertensive patients has positive cardiovascular effects, and music listening offers non-pharmacological ways to regulate heart rate and blood pressure. Presently, the most effective way to administer music inventions with long-lasting effects is labor-intensive and relies on professional therapists’ intuitions, making it non-scalable to large cohorts. H",{"id":335,"funder":7,"programme":8,"title":336,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":337},"cordis-european-research-council-award-875212","Augmenting the Value of Conversations with Voice Transformations","Project ACTIVATE aims to bring to market real-time voice-transformation technologies based on ERC CREAM's research in emotion neuroscience, which can augment the value of spoken conversations by adding business-relevant control on emotional expressivity. For instance, in the context of a call-center conversation, our real-time voice transformations may make an angry client’s voice 10% less aggressive, reducing employee fatigue at the end of the day, or make an operator’s voice 10% more trustwort",{"id":339,"funder":7,"programme":8,"title":340,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":341},"cordis-european-research-council-award-893772","Decreasing Pancreatic Adenocarcinoma-related Inflammation using small molecule inhibitors of STING","We will develop and test a treatment for pancreatic ductal adenocarcinoma (PDAC). To this aim, we will synthesize and evaluate the efficacy of novel inhibitors of nucleic acid-induced inflammation that we have identified. Indeed, nucleic acid-induced chronic inflammation is a major driver of tumorigenesis. Because the canonical pathway that triggers nucleic acid-induced chronic inflammation relies on the STING protein, identifying ways to activate or inhibit STING is a major goal of current rese",{"id":343,"funder":7,"programme":8,"title":344,"piName":10,"institution":75,"country":36,"year":13,"amount":14,"abstract":345},"cordis-european-research-council-award-899932","Computational discovery and design of disease-beating nutrition","With rapidly ageing populations, the world is experiencing an unsustainable healthcare and economic burden from chronic diseases such as cancer, cardiovascular, metabolic and neurodegenerative disorders. Diet and nutritional factors play an essential role in the prevention of these diseases and significantly influence disease outcome in patients during and after therapy. Everyday food ingredients contain multiple drug-like molecules that can potentially prevent or beat diseases. For example, it ",{"id":347,"funder":7,"programme":8,"title":348,"piName":10,"institution":213,"country":154,"year":13,"amount":14,"abstract":349},"cordis-european-research-council-award-875067","Implementation of contrast-ultrasound dispersion imaging for better prostate cancer care","Prostate cancer (PCa) causes 1\u002F5 of new cancer cases and 1\u002F10 of cancer deaths in western males. Timely diagnosis is crucial to enable effective treatment, but this is hampered by the inadequacy and cost of the available diagnostics based on multiple systematic biopsies, which cause discomfort and health risks because of their invasiveness. Moreover, they fail to provide accurate cancer localization, resulting in either over- or under-treatment. A new diagnostic method is thus needed that is acc",{"id":351,"funder":7,"programme":8,"title":352,"piName":10,"institution":353,"country":154,"year":13,"amount":14,"abstract":354},"cordis-european-research-council-award-964006","Active dielectric-on-Si3N4 double layer platform","UNIVERSITEIT TWENTE","aSINdo will study the technical feasibility and commercialization strategy of on-chip optical gain building blocks based on rare-earth ion doped Al2O3 that can be integrated onto passive integrated photonic material platforms, in particular Si3N4, to realize on-chip amplifiers and lasers.  The value proposition of this technology is to enable photonic integrated circuits to achieve sufficient output power to empower multiple emerging applications. Important advantages with respect to existing so",{"id":356,"funder":7,"programme":8,"title":357,"piName":10,"institution":358,"country":36,"year":13,"amount":14,"abstract":359},"cordis-european-research-council-award-899900","Bright and Compact Deep Ultraviolet Light Sources for Healthcare and Industry","HERIOT-WATT UNIVERSITY","We will use a new class of deep ultraviolet light source to address the biggest challenge facing modern medicine: the emergence of antimicrobial resistance (AMR): the resistance of bacteria (so-called “super bugs”) to anti-biotics. AMR is anticipated to cause 10 million deaths annually by 2050. The golden era of antibiotics is over, and the antibiotic pipeline is failing. We need to develop new technologies to target pathogens without antibiotics and to which pathogens cannot develop resistance.",{"id":361,"funder":7,"programme":8,"title":362,"piName":10,"institution":363,"country":42,"year":13,"amount":14,"abstract":364},"cordis-european-research-council-award-957502","IL-2 gene therapy for chronic hepatitis B virus infection","OSPEDALE SAN RAFFAELE SRL","Hepatitis B virus (HBV) infections remain a major public health issue worldwide. Over 350 -400 million people are chronically infected by HBV, and about 1 million people die each year from the complications of this infection (cirrhosis and hepatocellular carcinoma) with a consequent hefty economic impact on national health systems. This led the World Health Organization to recognise HBV infection as a key priority and adopt  the global health sector strategy to eliminate viral hepatitis, with a ",{"id":366,"funder":7,"programme":8,"title":367,"piName":10,"institution":368,"country":36,"year":13,"amount":14,"abstract":369},"cordis-european-research-council-award-899302","Machining and Commercialising Diamond Anvil Cells","THE UNIVERSITY OF EDINBURGH","The diamond anvil cell (DAC), a simple but versatile device, is the standard method of experimentally producing static high pressures. It consists of two movable parts containing opposing diamond anvils with a sample compressed between the polished culets (tips) and held by a metal gasket.  We are able to build DACs in the Mechanical Workshop at our institution. During the ERC-Hecate project we have developed many new innovations on making and using DACs.  Several groups around the world have ex",{"id":371,"funder":7,"programme":8,"title":372,"piName":10,"institution":373,"country":239,"year":13,"amount":14,"abstract":374},"cordis-european-research-council-award-957522","Easy-to-use diagnostic tool for the killing efficacy of antibiotics on clinical isolates","THE HEBREW UNIVERSITY OF JERUSALEM","This proposal aims to develop a low-cost diagnostic tool (SurviDisk) that can evaluate the killing efficacy of antibiotic treatments on bacterial strains isolated from patients. Current methods, such as the disk diffusion assay, only evaluate the ability of antibiotics to arrest the growth of bacteria. The size of the inhibition zone in the disk diffusion assay indicates the Minimum Inhibitory Concentration (MIC) i.e. the resistance level of the strain, but cannot distinguish between a cidal dru",{"id":376,"funder":7,"programme":8,"title":377,"piName":10,"institution":378,"country":148,"year":13,"amount":14,"abstract":379},"cordis-european-research-council-award-957468","LUCERO - Smart Optofluidic Micromanipulation of Biological Samples","GOETEBORGS UNIVERSITET","The goal of Lucero is to create autonomous micromanipulation solutions for biological applications integrating optical manipulation, microfluidics, and machine intelligence. Single-cell analysis is critical in many biomedical applications, such as clinical trials, in-vitro fertilization, forensic analysis, and single-cell omics. In fact, it is an ideal moment to enter the single-cell analysis market, because this market is valued at $1.4 billion globally and expected to keep on growing with a co",{"id":381,"funder":7,"programme":8,"title":382,"piName":10,"institution":383,"country":116,"year":13,"amount":14,"abstract":384},"cordis-european-research-council-award-899155","Regulating RAS Activity to Target RAS-Driven Cancers","TURUN YLIOPISTO","More than a quarter of all cancers are driven by mutations in the RAS family of genes. Considering the key role of these oncogenes, and despite intensive effort, no effective anti-RAS strategies have successfully made it to the clinic. In our ERC-CoG project, we found that a class of scaffold proteins, expressed in cancer, bind to active\u002Fmutated forms of RAS proteins to moderate RAS signalling. Accordingly, we find that loss of one of the scaffolding protein isoforms in RAS-mutant cancers trigge",{"id":386,"funder":7,"programme":8,"title":387,"piName":10,"institution":388,"country":154,"year":13,"amount":14,"abstract":389},"cordis-european-research-council-award-862113","Discovering a novel allergen immunotherapy in house dust mite allergy tolerance research","STICHTING AMSTERDAM UMC","The advances in medical sciences and biopharmaceutical development during the last decennia have been overwhelming. While the scientific and clinical insight in numerous diseases have significantly increased, the curative treatment to most diseases is still not in reach. The most common diseases such as cancer and chronic diseases are still challenging scientists. Therefore, during our ERC Advanced project the main goal was to develop a vaccine to cure cancer using targeted immunotherapy. We use",{"id":391,"funder":7,"programme":8,"title":392,"piName":10,"institution":393,"country":36,"year":13,"amount":14,"abstract":394},"cordis-european-research-council-award-957536","Shot-noise Limited Optical Waveguide MOdule","UNIVERSITY OF BRISTOL","Fibre lasers have become highly prevalent due to their cost, stability and practicality. However, they are inherently noisy and this is a severe limitation when using them for microscopy, spectroscopy or generate quantum states of light. We propose to develop a “plug-and-play” module that can be retrofitted to fibre lasers that are already deployed in the field, which reduces the optical noise at the laser output down to a fundamental limit of classical physics. This proof of concept grant will ",{"id":396,"funder":7,"programme":8,"title":397,"piName":10,"institution":398,"country":105,"year":13,"amount":14,"abstract":399},"cordis-european-research-council-award-964007","First principles based process concepts for complex mixtures conversion","UNIVERSITEIT GENT","Europe is the second largest global producer of hydrocarbon products. Unavoidably, significant greenhouse gas emissions occur due to the present process implementations. A proper simulation of these processes is crucial to better understand them and, hence, to propose solutions for the present challenges in CO2 emissions abatement. The PR1ME simulation framework for chemical process will combine the fundamental understanding of the occurring reactions at the microkinetic level with molecular rec",{"id":401,"funder":7,"programme":8,"title":402,"piName":10,"institution":403,"country":12,"year":13,"amount":14,"abstract":404},"cordis-european-research-council-award-899596","Graphene and related materials membranes for efficient removal of toxic cations from water","CENTRE INTERNATIONAL DE RECHERCHE AUX FRONTIERES DE LA CHIMIE FONDATION","GRAPHEME will combine chemically tailored graphene and related materials (GRMs) with capillary membranes (CMs) technology to engineer a radically new generation of CMs, exploiting simultaneously the outstanding adsorption properties of GRMs with the physical sieving potential of CMs, to ultimately improve the quality of potable water. GRMs’ hybrids hold a disruptive potential as sieving materials to boost the CMs performance as they possess an ideal tailor-made structure and tunable physicochemi",{"id":406,"funder":7,"programme":8,"title":407,"piName":10,"institution":388,"country":154,"year":13,"amount":14,"abstract":408},"cordis-european-research-council-award-963919","Drug discovery screening using human neurons","Brain disorders present a staggering health-care burden, costing around 800 billion euros per year in the EU and affecting almost 180 million people. Currently, development of treatments for these disorders is very unsuccessful. Of all currently prescribed drugs, >30% target G-protein coupled receptors, that are typically activated by neuromodulators. Neuromodulators are signaling molecules secreted by most neurons, which regulate many processes in our brain and body. Dysregulation of neuromodul",{"id":410,"funder":7,"programme":8,"title":411,"piName":10,"institution":412,"country":154,"year":13,"amount":14,"abstract":413},"cordis-european-research-council-award-885469","Assessing cardiac Contractility and Quantification of Underlying mechanisms In vitro via Response in Excitation-contraction coupling","ACADEMISCH ZIEKENHUIS LEIDEN","Academia and industry urgently needs reliable models to study heart failure and toxic effects of drugs on the heart. While new models based on human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are now emerging, accurate readouts of cardiomyocyte function fall short of needs. Apart from improving the models biologically, more sensitive, informative and accurate readouts are needed to detect abnormal cardiomyocyte behaviour. Several tools have proven their ability to assess el",{"id":415,"funder":7,"programme":8,"title":416,"piName":10,"institution":417,"country":116,"year":13,"amount":14,"abstract":418},"cordis-european-research-council-award-899436","Bio-based carbon fiber - commercialization","AALTO KORKEAKOULUSAATIO SR","Our modern societies are built on the mobility of the individual. Travelling to and from work, trips for leisure and shopping, or journeys to holiday destinations are integral part of our lives. The most popular means of transportation today is the private car. In 2016, the global car production has surpassed the 70 million mark for the first time. Irrespective of whether and when the mobility of our society will shift to electric vehicles, solutions are needed to increase the fuel and energy ef",{"id":420,"funder":7,"programme":8,"title":421,"piName":10,"institution":422,"country":30,"year":13,"amount":14,"abstract":423},"cordis-european-research-council-award-875302","Ocean-Bottom Distributed Acoustic Sensors: new tools for Underwater Seismology","UNIVERSIDAD DE ALCALA","One of the greatest outstanding challenges in seismology is the sparsity of instrumentation across Earth’s oceans. Poor spatial coverage results in biases and low-resolution regions in global tomography models as well as significant location uncertainty for offshore seismicity. Also, the lack of significant seismic instrumentation offshore makes it more complicated to have reliable early warning systems capable of mitigating some of the disastrous consequences of tsunamis. Ocean-bottom seismomet",{"id":425,"funder":7,"programme":8,"title":426,"piName":10,"institution":213,"country":154,"year":13,"amount":14,"abstract":427},"cordis-european-research-council-award-899808","Towards acoustic metafoams for broad-range sound insulation","Sound pollution is an omni-present problem in our modern society that affects our well-being and the quality of life. Technical solutions to reduce the impact of sound in a broad frequency range are therefore of vital importance. Moreover, solutions should be economically attractive, since the volumes of sound insulation required in our society are extremely large. Acoustic foams are nowadays one of the best available solution towards this problem, but they are mainly effective in the mid- and h",{"id":429,"funder":7,"programme":8,"title":430,"piName":10,"institution":431,"country":432,"year":13,"amount":14,"abstract":433},"cordis-european-research-council-award-862308","Projectile exciter for noiseless environment","BUDAPESTI MUSZAKI ES GAZDASAGTUDOMANYI EGYETEM","HU","Noise is not just a nuisance; it affects our health. No accepted financial data exist for the treatment costs of noise-related health problems, but several studies prove its direct relation to stress hormone levels or cardiovascular deceases, and many public organizations promote low-noise environment to protect health and comfort. Noise reduction has become major field of manufacturers’ competition: noise level data appear on domestic machines from mixers to dishwashers, brand names with ‘whisp",{"id":435,"funder":7,"programme":8,"title":436,"piName":10,"institution":437,"country":24,"year":13,"amount":14,"abstract":438},"cordis-european-research-council-award-899428","Next Generation of Concentrated Photovoltaics Using Node Concentrators","BERGISCHE UNIVERSITAET  WUPPERTAL","I invented a thin plastic foil capable of collecting sunlight from a certain incident angle and guiding it to a spot of intense light emission, thereby concentrating the light by a factor of 300 and more. In the first step, ConPhoNo will evaluate the application of the foils for safety features. Here, the foils will be laminated to a product showing bright colorful pictures when properly aligned to the sun. This application exhibits a high chance of success as the technical feasibility has alrea",{"id":440,"funder":7,"programme":8,"title":441,"piName":10,"institution":442,"country":36,"year":13,"amount":14,"abstract":443},"cordis-european-research-council-award-899872","BANKED HEPATOCYTE MONOLAYERS FOR ACCELERATING DRUG TOXICITY SCREENING","UNIVERSITY OF WARWICK","This proof of concept grant will transform how liver cells are cryopreserved for the toxicological testing market, translating scientific findings emerging from an ERC starter grant from lab to real application.During the drug discovery process, the leading cause of new candidate drug rejection is the discovery of an unfavourable toxicological profile. It is essential to discover these as early as possible in the process to minimize costs and ensure favourable candidates are taken forward and to",{"id":445,"funder":7,"programme":8,"title":446,"piName":10,"institution":368,"country":36,"year":13,"amount":14,"abstract":447},"cordis-european-research-council-award-862559","Novel Characterisation Platform for Formulation Industry","We propose a novel platform for particle characterisation in diverse applications making use of colloidal suspensions. These are ubiquitous in applications across many sectors: agriculture, food, household and personal care goods, paints and coatings, oil, water treatment, etc.. In other applications, the role of suspensions is less obvious, but no less vital: molten chocolate is a suspension of sugar crystals in oil, while all ceramics start as particulate pastes (of, e.g. titania) before sinte",{"id":449,"funder":7,"programme":8,"title":450,"piName":10,"institution":451,"country":452,"year":13,"amount":14,"abstract":453},"cordis-european-research-council-award-899262","Large-scale platform for motion detection and fluorescence imaging in zebrafish models of neurological disorders","ASOCIATIA TRANSYLVANIAN INSTITUTE OF NEUROSCIENCE","RO","The PhenoTECH project aims to develop a novel technology with high-throughput capacity for screening and phenotyping of genetic models of disease. PhenoTECH will enable an unprecedented capability to monitor and control multiple parameters that will significantly contribute to advancing fundamental and biopharmaceutical research, strongly accelerating discovery of novel treatments for debilitating neurodegenerative diseases. PhenoTECH’s immediate impact will be on the ERC Consolidator Grant, ALS",{"id":455,"funder":7,"programme":8,"title":456,"piName":10,"institution":457,"country":12,"year":13,"amount":14,"abstract":458},"cordis-european-research-council-award-957546","Ophtalmic Device for eYe StructureS Examination with Ultrahigh reSolution","ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS","Non-contact cell-resolution imaging of the whole eye is the Holy Grail of ophthalmic diagnosis. If achieved and wide-spread, it can allow detection of diseases at the very earliest stages, resulting in a prominent positive effect both on society through improving the ocular health in the population, and on economy through reducing the number of costly surgical interventions at the late disease stages and through keeping the population economically active. Several highresolution eye imaging instr",{"id":460,"funder":7,"programme":8,"title":461,"piName":10,"institution":462,"country":30,"year":13,"amount":14,"abstract":463},"cordis-european-research-council-award-957488","Genomic Data-Fusion Platform for Omics-Driven Precision Medicine","BARCELONA SUPERCOMPUTING CENTER CENTRO NACIONAL DE SUPERCOMPUTACION","This PoC project aims to pave the road to commercialize a comprehensive data analytics platform enabling data-driven biomedical innovation and precision medicine. The platform is specifically designed to efficiently fuse and mine heterogeneous omic data, including genomes,epigenomes, proteomes, metabolomes, patient clinical profiles, drugs and their chemical similarities, disease and otherontologies, and other relevant omic data. The goal of this development is to provide the most advanced softw",{"id":465,"funder":7,"programme":8,"title":466,"piName":10,"institution":467,"country":36,"year":13,"amount":14,"abstract":468},"cordis-european-research-council-award-957480","The Multimedia Yasna International Image Interoperability Framework","SCHOOL OF ORIENTAL AND AFRICAN STUDIES ROYAL CHARTER","Images published on the Web are currently locked up in silos because institutions use different image delivery software on their networks, one that is usually tightly coupled with their custom metadata structures. This has led to isolated data silos that prevent information to be easily reused. The International Image Interoperability Framework (IIIF) solves this problem with a set of protocols or Application Programming Interfaces (API), for requests between computers to allow images and metada",{"id":470,"funder":7,"programme":8,"title":471,"piName":10,"institution":472,"country":148,"year":13,"amount":14,"abstract":473},"cordis-european-research-council-award-957557","High-Q filter banks enabling unprecedented selective and high-sensitivity radiometers for environmental sensing","KUNGLIGA TEKNISKA HOEGSKOLAN","This project proposes a new architecture of sub-terahertz (THz) radiometers, which, for the first time, allows to combine high frequency selectivity, high sensitivity and high compactness, intended to be used in Earth-observation environmental sensing applications.There exists two radiometer detector types: 1) direct-detectors have best-possible sensitivity, but poor frequency selectivity, even when equipped with superconductive filters which require bulky and energy-demanding cryogenic cooling ",{"id":475,"funder":7,"programme":8,"title":476,"piName":10,"institution":477,"country":42,"year":13,"amount":14,"abstract":478},"cordis-european-research-council-award-957538","Flexible and User-defined Technologies for Unconstrained neural Recording Experiments in Non-Human Primates","UNIVERSITA DEGLI STUDI DI PARMA","Some of the greatest today’s challenges in understanding human brain functions and dysfunctions are being tackled by using Non-Human Primates (NHPs), a unique and still unreplaceable model in neurophysiology because of their remarkable anatomo-functional, cognitive and behavioural similarities to humans. Tethered neural recordings have been, so far, the virtually unique methodology available for these studies. Nonetheless, this approach 1) limits the range of behaviours and functions that can be",{"id":480,"funder":7,"programme":8,"title":481,"piName":10,"institution":482,"country":432,"year":13,"amount":14,"abstract":483},"cordis-european-research-council-award-899747","Continuous-flow Photoelectrochemical Cells for Carbon Dioxide Valorization","SZEGEDI TUDOMANYEGYETEM","Technologies utilizing carbon-dioxide (CO2) as a feedstock to generate valuable products will play a key role in turning the chemical industry onto a more sustainable path. This project addresses the efficient utilization of solar energy and CO2 by introducing a novel technology to produces base chemicals and fuels from non-fossil fuel resources, using an original device architectures for the direct photoelectrochemical (PEC) conversion of CO2 and H2O. During my ERC Starting Grant project we hav",{"id":485,"funder":7,"programme":8,"title":486,"piName":10,"institution":487,"country":30,"year":13,"amount":14,"abstract":488},"cordis-european-research-council-award-899541","Visible Light-Activated Photoinitiators for Applications in Domestic Coatings","FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA","The use of light to trigger and control radical polymerisation is a powerful strategy for rational polymer synthesis and advanced materials. Photoinitiated polymerisation is today widely used in industry for several applications. Essential for the continued progress of the field is the discoveries of novel photoinitiators endowed with tailored properties, such as high activity at ambient temperature and the possibility to use visible light instead of UV irradiation to produce radicals in high qu",{"id":490,"funder":7,"programme":8,"title":491,"piName":10,"institution":164,"country":154,"year":13,"amount":14,"abstract":492},"cordis-european-research-council-award-862506","TRAF-STOP therapy to reduCe inflammation in athERosclerosis.","Atherosclerosis, the underlying cause of the majority of cardiovascular diseases, is a lipid driven, inflammatory disease ofthe large arteries. Despite a 25% relative risk reduction achieved by lipid-lowering treatment, the vast majority ofatherosclerosis induced cardiovascular disease risk remains unaddressed. Therefore, characterizing mediators of theinflammatory aspect of atherosclerosis is a widely recognized scientific goal with great therapeutic implications. Blocking theco-stimulatory CD4",{"id":494,"funder":7,"programme":8,"title":495,"piName":10,"institution":249,"country":250,"year":13,"amount":14,"abstract":496},"cordis-european-research-council-award-862595","Microfabricated hydrogel-based complex patch with time dependent controlled multiple-release of biomolecules for improved healing of skin wounds","Skin wounds represent a significant economic and social burden, associated with a long-lasting nature and need of care. Most of the commercially available patches for wound healing have been proved very useful in wound management but are yet to demonstrate a direct effect on the progression of the healing. This has significant implications in the quality of the clinical results obtained so far. Skin patches can be substantially improved in terms of the healing time, with clear benefits in the pa",{"id":498,"funder":7,"programme":8,"title":499,"piName":10,"institution":500,"country":239,"year":13,"amount":14,"abstract":501},"cordis-european-research-council-award-899224","Repurposing a known drug to treat heart diseases","WEIZMANN INSTITUTE OF SCIENCE","Coronary Heart Disease (CHD) and particularly Myocardial Infarction (MI), i.e. heart attack, is the leading cause of death in the Western world today. The main cause for CHD is the incapacity of the mammalian heart to undergo regeneration after injury. Current therapies are not able to address the central problem of decreased pumping capacity that results from the depleted pool of cardiac muscle cells. The outcome of this shortcoming is grim; nearly half of all patients with heart failure die wi",{"id":503,"funder":7,"programme":8,"title":504,"piName":10,"institution":505,"country":105,"year":13,"amount":14,"abstract":506},"cordis-european-research-council-award-963281","Solvometallurgy for battery-grade refining of lithium","KATHOLIEKE UNIVERSITEIT LEUVEN","To allow the rollout of e-mobility and stationary renewable energy storage in Europe, a secure, affordable and sustainable supply of battery-grade lithium salts for Li-ion batteries (LIBs) is key. However, Europe’s lithium supply chain is extremely vulnerable: Europe’s primary lithium resources (present as “hard rock”) are underexploited and, even if lithium would be mined domestically, there is no lithium refining capacity available in Europe to process the lithium into battery-grade lithium sa",{"id":508,"funder":7,"programme":8,"title":509,"piName":10,"institution":510,"country":12,"year":13,"amount":14,"abstract":511},"cordis-european-research-council-award-899928","Bright nanoparticle probes for amplified fluorescence in situ hybridization in cancer diagnostics","UNIVERSITE DE STRASBOURG","Rapidly expanding field of cancer diagnostics generates strong demand for new biosensing tools. In particular, it concerns probes for fluorescence in situ hybridization (FISH), that enables detection of DNA and RNA cancer biomarkers directly in diseased cells. Although FISH technique has already been accepted for cancer diagnostics in clinics, its applications are still limited because the method is slow, expensive and requires complicated amplification protocols to obtain sufficient fluorescenc",{"id":513,"funder":7,"programme":8,"title":514,"piName":10,"institution":515,"country":36,"year":13,"amount":14,"abstract":516},"cordis-european-research-council-award-899779","Social wearable sensors to support engagement and learning in children with autism + learning difficulties.","UNIVERSITY COLLEGE LONDON","Children with autism and learning difficulties often need substantial support in schools and in later life with communication, emotion regulation and daily living skills.  Teaching these children and measuring their progress in education is challenging.  Our recent work (ERC grant INTERACT 313398) showed that tracking body motion in children and adults can give a real-world measure of how much people are engaged in a social interaction.  In this project, we develop this result into a wearable se",{"id":518,"funder":7,"programme":8,"title":519,"piName":10,"institution":520,"country":521,"year":13,"amount":14,"abstract":522},"cordis-european-research-council-award-957561","Road to Market for Fully Implantable Cochlear Implant: Phase 1","MIDDLE EAST TECHNICAL UNIVERSITY","TR","Today, congenital or acquired hearing loss affects around 6% of the world population (over 460 M people, of 7% are children) and presents significant impact on people’s social, emotional, and economic wellbeing. Sensorineural impairment, which represents the majority of the profound deafness, is caused from irreversible damage to cochlear hair cells rendering them non-functional\u002Fmissing. It can be restored using cochlear implants (CIs), which are used to bypass the damaged hair cells and directl",{"id":524,"funder":7,"programme":8,"title":525,"piName":10,"institution":526,"country":24,"year":13,"amount":14,"abstract":527},"cordis-european-research-council-award-963987","Validating markets for sustainable sensing grippers in micro assembly","INM - LEIBNIZ-INSTITUT FUER NEUE MATERIALIEN GEMEINNUETZIGE GMBH","Since Adam and Eve’s infamous apple, gripping, handling and releasing objects has been a thoroughly human activity: the hand and fingers combine muscular action with sensing, complemented by feedback from visual monitoring. Modern automation technology, e.g. in production and micro assembly lines, is now facing the challenge of manipulating of extremely small objects, with dimensions typically smaller than the width of a human hair. Existing gripping technologies are running out of steam in this",{"id":529,"funder":7,"programme":8,"title":530,"piName":10,"institution":531,"country":24,"year":13,"amount":14,"abstract":532},"cordis-european-research-council-award-957272","PortPath: A Portable Device for Detecting Pathogens","TECHNISCHE UNIVERSITAT BERLIN","Many of today’s water resources are contaminated by pathogenic bacteria, which cause serious diseases, especially in low-income countries. One particularly grave concern is Vibrio cholerae, the disease-causing agent of cholera, with an estimated 1.3 to 4.0 million cases worldwide every year and an estimated annual mortality rate of up to 143,000 people. The current state-of-the-art detection methods for this pathogen have high demands on the equipment and on the expertise of the investigating pe",{"id":534,"funder":7,"programme":8,"title":535,"piName":10,"institution":536,"country":42,"year":13,"amount":14,"abstract":537},"cordis-european-research-council-award-957533","Development and implementation of a diagnostic, preventive and prognostic strain-level microbial test for peri-implant diseases","PREBIOMICS SRL","Oral diseases are a global medical and socioeconomic burden. Diseases affecting dental implants (peri-implant mucositis and peri-implantitis) are particularly on the rise, and despite the plaque microbiome plays a crucial role in their etiology, the potential of profiling the microbial communities around implants for supporting implant care has not been exploited yet for clinical applications. The availability of metagenomic tools able to profile human microbiomes at unprecedented resolution dev",{"id":539,"funder":7,"programme":8,"title":540,"piName":10,"institution":541,"country":30,"year":13,"amount":14,"abstract":542},"cordis-european-research-council-award-899636","Proof of concept of prognostic test for critical Septic Patients based in Early Detection of NLRP3 Inflammasome impairment activation.","FUNDACION PARA LA FORMACION E INVESTIGACION SANITARIAS DE LA REGION DE MURCIA","Sepsis remains the leading cause of death in critical care units of Hospitals, affecting more that 18 million people worldwide and causes a systemic inflammatory response driven by the production of proinflammatory cytokines. Several studies have been conducted to find out whether data mining and machine learning could be used to identify patients at risk of sepsis. Although the currently available biomarkers can help shorten this decision process, there is still a need for additional early dise",{"id":544,"funder":7,"programme":8,"title":545,"piName":10,"institution":546,"country":24,"year":13,"amount":14,"abstract":547},"cordis-european-research-council-award-899880","Unlocking the potential of machine learning for SMEs by automated machine learning","ALBERT-LUDWIGS-UNIVERSITAET FREIBURG","Machine learning has become a key technology for modern data-driven industrial applications. This success is built on recent research advances in the field of artificial intelligence and more specifically was enabled by key advances in machine learning. Unfortunately, the performance of many machine learning methods is very sensitive to a myriad of design decisions and thus requires a significant amount of machine learning expertise which is often rare and makes this technology inaccessible for ",{"id":549,"funder":7,"programme":8,"title":550,"piName":10,"institution":551,"country":320,"year":13,"amount":14,"abstract":552},"cordis-european-research-council-award-875516","Implementation and preclinical testing of a closed-loop control system for deep brain stimulation","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","Over the past 25 years deep brain stimulation (DBS) has emerged as an effective treatment for the symptoms of Parkinson's disease (PD). Despite its success, the mechanisms of DBS are not yet fully understood. Moreover, patients experience side effects and poor control of symptoms associated with suboptimal programming of stimulus parameters.  Current DBS systems operate in an 'open-loop' configuration with stimulus parameters (pulse amplitude, duration and frequency) empirically set and remainin",{"id":554,"funder":7,"programme":8,"title":555,"piName":10,"institution":556,"country":154,"year":13,"amount":14,"abstract":557},"cordis-european-research-council-award-899891","Intelligent Multi-modal Transfer Flow Management system","TECHNISCHE UNIVERSITEIT DELFT","In sustainable transport systems, the role of multi-modal trips is increasingly important. Access, egress, and transferring within or between modes is an important source of trip disutility. The transfer experience needs to be substantially improved for multi-modal trips to be able to compete with car travel.  This proposal focusses on making transfers at multi-modal transfer hubs as efficient, reliable and safe for the traveller as possible within existing transfer hubs using advanced sensing a",{"id":559,"funder":7,"programme":8,"title":560,"piName":10,"institution":353,"country":154,"year":13,"amount":14,"abstract":561},"cordis-european-research-council-award-897025","Validation of Open organ-on-chip Technology for End user applications","Organ-on-Chips, and more general microphysiological systems, are believed to revolutionize the way we develop drugs or select personalized therapies. Recapitulating human response both from healthy and diseased individuals potentially even enables ‘clinical trials in-a-dish’. While research in this field is thriving and commercial start-ups have been founded, adoption from end users is staying behind due to a number of reasons: i) lack of standardization making chips not compatible with each oth",{"id":563,"funder":7,"programme":8,"title":564,"piName":10,"institution":515,"country":36,"year":13,"amount":14,"abstract":565},"cordis-european-research-council-award-875669","Development of a prototype clinical photoacoustic scanner for use in plastic and reconstructive surgery","Plastic and reconstructive surgical procedures provide a means of reconstructing tissues following damage due to cancer, trauma, burns and infections. An important example is flap surgery which involves transferring skin and the underlying tissues from one part of the body to another; for example, in the DIEP flap breast reconstruction procedure, skin and tissue from the abdomen is removed and implanted in the breast. For a successful repair, it is essential that the transplanted tissue develops",{"id":567,"funder":7,"programme":8,"title":568,"piName":10,"institution":569,"country":137,"year":13,"amount":14,"abstract":570},"cordis-european-research-council-award-899775","Scalable excitonic devices","ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE","EXCITE aims to deliver a key, scalable, industrial manufacturing process that will enable the production of excitonic devices for a wide range of applications. Our innovation can create a new market represented by excitonic devices using 2D materials as energy-efficient interconnects.  The demonstration of room-temperature control could open the way to industrial applications of the excitonic device concept, with an excitonic switch and optical modulator being the first types of devices that cou",{"id":572,"funder":7,"programme":8,"title":573,"piName":10,"institution":569,"country":137,"year":13,"amount":14,"abstract":574},"cordis-european-research-council-award-899792","Introducing the first fully flow-conveyed and magnetically-steered microcatheter system","Minimally invasive medical procedures, such as endovascular catheterization, have drastically reduced procedure-associated risks for patients and costs for hospitals. However, practitioners still cannot quickly and safely reach deep body tissues due to the miniaturization issues associated with the existing manufacturing paradigm and the tedious process of navigating commercially available catheters. MagFlow introduces an innovative approach towards minimally invasive surgery that realizes the d",{"id":576,"funder":7,"programme":8,"title":577,"piName":10,"institution":569,"country":137,"year":13,"amount":14,"abstract":578},"cordis-european-research-council-award-875672","Portable infrared biochemical sensor enabled by pixelated dielectric metasurfaces","Mid-infrared spectroscopy is considered gold standard in bio-chemical analysis for both research and industry applications, providing chemical specificity, as well as a label-free and non-destructive way of accessing molecular structure on a wide range of samples. Currently available infrared (IR) sensor techniques rely on bulky and expensive Fourier transform infrared spectrometers or tunable light sources, which severely limits their use in field and practical applications. Therefore, there is",{"id":580,"funder":7,"programme":8,"title":581,"piName":10,"institution":203,"country":36,"year":13,"amount":14,"abstract":582},"cordis-european-research-council-award-963872","Cellulose scattering enhancers for replacement of Titania nanoparticles","Nanomaterials, especially if bio-sourced, have huge promise in a wide range of applications of societal importance to replace inorganic and synthetic counterparts. This is particularly important in the pigment industry, which has long relied on the use of inorganic nanoparticles as scattering enhancers. Now there is a growing demand for natural and sustainable alternatives that avoid the growing concerns over potential long-term health impacts of inorganic materials such as Titanium dioxide (TiO",{"id":584,"funder":7,"programme":8,"title":585,"piName":10,"institution":264,"country":42,"year":13,"amount":14,"abstract":586},"cordis-european-research-council-award-899412","In-situ fabricated hydrogen evolution catalysts for alkaline water electrolysis","Hydrogen could replace fossil fuels, and electrolytic water splitting using renewable energy sources is a promising way to obtain it. The most active hydrogen evolution reaction (HER) electrocatalysts to date are platinum group metals (PGM), mainly Pt and its alloys, deposited onto a carbon support. Pt is however costly and the catalysts degrade over time, due to aggregation of metal nanoparticles over the support. Also, no valuable contenders to Pt group metals have been identified for the alka",{"id":588,"funder":7,"programme":8,"title":589,"piName":10,"institution":255,"country":239,"year":13,"amount":14,"abstract":590},"cordis-european-research-council-award-957551","Thermally stable nonporous gold for improved automotive catalytic converters","70% of the toxic gasses emitted from automotive exhaust systems originates from the first 60 seconds of the cold start. Severe health effects are associated with air pollution from motor vehicles. In fact, it causes 6% of total mortality per annum, half of which is attributed to vehicle emissions. Current catalytic converter technology relies on expensive platinum group metals (Pt, Pd, Rh) which are very effective in oxidizing these toxic gases at elevated engine working temperatures, however, t",{"id":592,"funder":7,"programme":8,"title":593,"piName":10,"institution":213,"country":154,"year":13,"amount":14,"abstract":594},"cordis-european-research-council-award-899942","An innovative peptide system for novel drugs targeting microbial Repeats-In-Toxin adhesins","Despite progress in infection treatment in the last decades, the prevalence and mortality of infections still poses a heavy burden over humankind. The development of antimicrobial resistance and the rapid mutagenesis of bacteria that leads to inefficiency of vaccines, play an important role in maintaining infections high level of threat. Even diseases that have plagued us for centuries, such as cholera, still challenge medical professionals and cause a significant social cost. New therapeutic ap",{"id":596,"funder":7,"programme":8,"title":597,"piName":10,"institution":500,"country":239,"year":13,"amount":14,"abstract":598},"cordis-european-research-council-award-899122","Development and commercialization of kit for quantitative interrogation of a key RNA modification","N6-Methyladenosine (m6A) plays fundamental roles in regulation of metabolism, stem cell self-renewal, and metastasis. Consistently its dysregulation is implicated in a variety of human cancers including leukemia, glioblastoma and hepatocellular carcinoma. Consequently, the potential of m6A both as a novel cancer diagnostic and as a drug target has raised immense interest in scientific community and industry. For unravelling m6A functions, for the development of therapeutics and for prioritizing ",{"id":600,"funder":7,"programme":8,"title":601,"piName":10,"institution":602,"country":24,"year":13,"amount":14,"abstract":603},"cordis-european-research-council-award-957547","Establishment of three-parent crosses in crop plants for commercial exploitation","UNIVERSITAET BREMEN","There is an urgent need for an agricultural revolution to generate climate-smart cultivars, which combine proven qualities with novel traits that adapt crop plants to extremes, including severe heat and drought periods. Novel breeding technologies can make the difference to enable farmers to achieve high yields with resilient crops and thus secure the nutrition for the world population. In the framework of the ERC Consolidator Grant Building and bypassing polyspermy barriers we have discovered t",{"id":605,"funder":7,"programme":8,"title":606,"piName":10,"institution":607,"country":24,"year":13,"amount":14,"abstract":608},"cordis-european-research-council-award-899701","Strain-stiffening vascular graft with outstanding compliance","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","Cardiovascular diseases are one of the major causes of death in the EU and appropriate treatment remains challenging and expensive. Often, the only treatment option is the replacement of a native blood vessel, for example if a coronary artery bypass is needed. Although patient-derived vascular grafts remain the gold standard as a replacement of the original vessel, alternatives have to be found, as donor material is limited. Currently available synthetic grafts have several drawbacks in comparis",{"id":610,"funder":7,"programme":8,"title":611,"piName":10,"institution":612,"country":24,"year":13,"amount":14,"abstract":613},"cordis-european-research-council-award-875677","Dipeptide-Repeat Vaccine to prevent ALS and FTD in C9orf72 mutation carriers","DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV","Neurodegenerative diseases are triggered by protein aggregation in the CNS, but developing therapies has been challenging. Since key disease mechanisms change during disease progression, halting further neuron loss has not been achieved and may not even improve the symptoms and survival. Causal therapy is most realistic for monogenic disease variants.About 10% of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) cases are caused by repeat expansion in the C9orf72 gene. We hav",{"id":615,"funder":7,"programme":8,"title":616,"piName":10,"institution":617,"country":154,"year":13,"amount":14,"abstract":618},"cordis-european-research-council-award-957565","A fully automated deep learning-based software for fast, robust and accurate detection and segmentation of tumours and metastasis","UNIVERSITEIT MAASTRICHT","The inaccuracy and inconsistency of state-of-the-art tumour volume detection and segmentation has an adverse influence on patient outcomes. Accurately determining the exact location and volume of tumours is a prerequisite for the detection, segmentation, characterisation and therapy response monitoring for any type of cancer. Today, tumour segmentation is performed manually or semi-automatically in a laborious and time-consuming process that exhibits low accuracy and inconsistency. This compromi",{"id":620,"funder":7,"programme":8,"title":621,"piName":10,"institution":164,"country":154,"year":13,"amount":14,"abstract":622},"cordis-european-research-council-award-875174","Effective management of pregnant cancer patients through a cloud-based integrative and highly specialized advisory board platform","Although cancer in pregnancy (CIP) is rare (one in 1000-2000 pregnancies), it has an important impact on society as it annually affects more than 200,000 pregnant women worldwide. The ERC-CoG project “CRADLE”, has led to the finding that management of cancer in pregnancy requires a specialized multidisciplinary care of not only physicians within the oncology field but also in gynaecology, obstetrics, perinatology and psychology. However, as CIP is a rare event, most physicians are rarely confron",{"id":624,"funder":7,"programme":8,"title":625,"piName":10,"institution":626,"country":521,"year":13,"amount":14,"abstract":627},"cordis-european-research-council-award-899907","Holographic Vision Simulator for Cataract Surgery","KOC UNIVERSITY","Cataract is the most prevalent visual disorder and blinding disease in the world. Cataracts cannot be corrected with eyeglasses or contact lenses. Surgery is the only option for improved vision, however, vision simulators for different types of cataracts are limited and vision simulator for different types of intra-ocular lens options do not exist. In this project, computational holographic display technology, which was developed during PI's ERC-AdG project, will be exploited for medical applica",{"id":629,"funder":7,"programme":8,"title":630,"piName":10,"institution":631,"country":12,"year":13,"amount":14,"abstract":632},"cordis-european-research-council-award-963840","Optimal urban traffic routing by broadcasting avoidance maps","UNIVERSITE GUSTAVE EIFFEL","The PoC aims to develop a prototype for an optimal route guidance system that improves traffic conditions in urban areas. Urban traffic management at large-scale is very challenging but may lead to significant travel time savings by better-distributing drivers among the network. Existing navigation apps or routing systems provide the shortest-path in time to users resulting in the network user equilibrium. However, traffic engineers know that total travel times may be reduced by 10 to 30% if use",{"id":634,"funder":7,"programme":8,"title":635,"piName":10,"institution":636,"country":36,"year":13,"amount":637,"abstract":638},"cordis-european-research-council-award-790240","Biomineralizing coatings for maxillofacial implants","THE UNIVERSITY OF NOTTINGHAM","€149,796","There is great need for more effective bone grafts to treat craniomaxillofacial (CMF) complications. Bone grafting, which accounted for 24 million procedures and $3.3 billion in sales worldwide in 2010, is critical to treat CMF complications associated to trauma, tumour removal, or congenital disorders. However, the use of traditional autogenous or allogenic grafts possesses a number of problems. MINGRAFT aims to establish a new scalable bioactive coating for bespoke implants to treat mandibular",{"id":640,"funder":7,"programme":8,"title":641,"piName":10,"institution":642,"country":12,"year":13,"amount":14,"abstract":643},"cordis-european-research-council-award-875532","Reliable urinary test for the diagnosis of prostate cancer","INSTITUT CURIE","Reliable urinary test for the diagnosis of prostate cancer Prostate cancer is a life threatening disease which affects about 400,000 males and causes 92,000 deaths per year in Europe. Among suspected cancer patients who undergo a prostate biopsy, only 45% really have a cancer. However, this diagnostic procedure is associated with discomfort, anxiety, bleeding, and the potential for serious infections requiring hospitalization. It is also very expensive. None of the tests available today offer an",{"id":645,"funder":7,"programme":8,"title":646,"piName":10,"institution":373,"country":239,"year":13,"amount":14,"abstract":647},"cordis-european-research-council-award-957543","A Promising Treatment of WWOX Associated Neurological Disorders","A Promising Treatment of WWOX Associated Neurological DisordersWWOXAIDWWOX-related epileptic encephalopathy (WOREE) syndrome, also known as early infantile epileptic encephalopathy, 28 (EIEE28, OMIM: 616211), is a very severe epileptic encephalopathy characterized by absence of language development and acquisition of walking, early-onset drug-resistant seizures, ophthalmological involvement, and a very high likelihood of premature death. Above all, WWOXAID aims to set the basis for bringing into",{"id":649,"funder":7,"programme":8,"title":650,"piName":10,"institution":378,"country":148,"year":13,"amount":14,"abstract":651},"cordis-european-research-council-award-963936","SERIAL CRYSTALLOGRAPHY SOLUTIONS FOR SYNCHROTRON RADIATION FACILITIES","Serial-X aims to expand of the use of serial crystallography across the academic and industrial life-science community by introducing low cost, flexible and easy to use solutions to the most common problems that occur in serial crystallography experiments today. Serial crystallography is a developing method of macromolecular X-ray crystallography that allows diffraction data to be collected at room temperature from a continuous stream of microcrystals. “ProtonPump”, the ERC Advanced Grant awarde",{"id":653,"funder":7,"programme":8,"title":654,"piName":10,"institution":295,"country":36,"year":13,"amount":14,"abstract":655},"cordis-european-research-council-award-862565","A portable instrument (PINE) for the autonomous detection of atmospheric ice nucleating particles aimed at the research, global monitoring and cloud seeding markets","It is becoming increasingly clear that a class of atmospheric aerosol particles which catalyse ice formation have a profound impact on clouds, precipitation and climate. For example, recent research demonstrates that massive cloud systems the size of Western Europe are almost completely removed by sufficient ice nucleating particles. However, the global distribution of ice nucleating particles is extremely poorly characterised, in part due to the lack of instrumentation which can be used for the",{"id":657,"funder":7,"programme":8,"title":658,"piName":10,"institution":659,"country":36,"year":13,"amount":14,"abstract":660},"cordis-european-research-council-award-956779","Bespoke Resists for Next Generation Nanofabrication","THE UNIVERSITY OF MANCHESTER","Interactions with end users of resist technologies suggest there is a market opportunity to develop resists that are tailored for specific applications - which we are calling Bespoke Resists. End users also require careful validation of performance of such bespoke resists. During BERNGEN we will examine possible workflows to achieve such bespoke resists in a manner suitable to supply to a wide range of end users.",{"id":662,"funder":7,"programme":8,"title":663,"piName":10,"institution":664,"country":30,"year":13,"amount":14,"abstract":665},"cordis-european-research-council-award-963912","Silicon nanowire fabrics for high energy density batteries","FUNDACION IMDEA MATERIALES","Meeting European energy storage in transport, stationary and emerging sectors requires annual cell capacity of at least 200 GWh in the next 5 years, calling for urgent development of new materials for LIBs that increase energy\u002Fpower density at lower costs. Silicon, an abundant material with 10-fold higher capacity than graphite, has shown promise as anode material when appropriately nanostructured. The challenge is in producing nanostructured Si networks using simple and scalable processes leadi",{"id":667,"funder":7,"programme":8,"title":668,"piName":10,"institution":669,"country":42,"year":13,"amount":14,"abstract":670},"cordis-european-research-council-award-875183","Use of drones for Emergency management","POLITECNICO DI TORINO","Firefighters fatalities are increasing worldwide because they are the first entering in damaged buildings or in fire, without knowing the location of victims and the source of danger. The Principal Investigator has invented a system for indoor tracking that is able to detect victims inside buildings after a disaster (earthquake, fire, etc.) using a radio frequency system (UWB) based on fixed nodes (anchors) in the building to detect the location of wearable nodes (tags).  The application has bee",{"id":672,"funder":7,"programme":8,"title":673,"piName":10,"institution":674,"country":675,"year":13,"amount":14,"abstract":676},"cordis-european-research-council-award-957464","Chip-based nanoscopy: an affordable, multi-modal and high-throughput super-resolution imaging platform","UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET","NO","The invention of optical nanoscopy is about to revolutionize several disciplines and it was awarded with a Nobel Prize in Chemistry in 2014. It is widely believed that a majority of existing optical microscopes will be replaced by an optical nanoscope. Unfortunately, the potential of the such a revolution and its widespread adoption are severely obstructed due to limitations of present day nanoscopy solution, i.e. system complexity, high cost and low throughput. In my ERC project, I have develop",{"id":678,"funder":7,"programme":8,"title":679,"piName":10,"institution":680,"country":24,"year":13,"amount":14,"abstract":681},"cordis-european-research-council-award-899429","Noncoding RNA MEG3 inhibitor for Heart Failure Treatment","MEDIZINISCHE HOCHSCHULE HANNOVER","Cardiac fibrosis is a hallmark of and mechanistically involved in heart failure; a disease will high clinical unmet need and fundamental socioeconomic importance. Specific treatments of cardiac fibrosis are lacking. RNAs that do not code for proteins comprise a large portion of the human genome. These so-called noncoding RNAs are emerging as important players in disease pathogenesis, yet their functional roles are ill understood. Our group currently pioneered first clinical testings on noncoding",{"id":683,"funder":7,"programme":8,"title":684,"piName":10,"institution":685,"country":137,"year":13,"amount":14,"abstract":686},"cordis-european-research-council-award-875610","Novel selective mTORC1 inhibitors","UNIVERSITAT BASEL","Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and the fourth leading cause of cancer-related deaths worldwide. The multikinase inhibitor sorafenib is the only approved drug to treat HCC and on average enhances survival by three months. Thus, the efficacy of current HCC treatment options is very limited. Studies in the context of our ERC-Synergy grant revealed that sorafenib resistance correlates with upregulation of mammalian target of rapamycin complex 1 (mTORC1) signal",{"id":688,"funder":7,"programme":8,"title":689,"piName":10,"institution":690,"country":320,"year":13,"amount":14,"abstract":691},"cordis-european-research-council-award-899774","HEterodyne RefraCtive index sensor Using photonic crystal LaSers","MUNSTER TECHNOLOGICAL UNIVERSITY","In the HERCULES project, we will improve the refractive index detection limit by 3 orders of magnitude relative to the state of the art, by implementing an on-chip optical heterodyne measurement using one of the brand-new semiconductor lasers developed during the DANCER starting grant. The detection limit (DL) is the key measure of the performance of a RI sensor and determines the smallest change in refractive index that a sensor can detect. The DL is a function of the RI sensitivity, which is t",{"id":693,"funder":7,"programme":8,"title":694,"piName":10,"institution":183,"country":137,"year":13,"amount":14,"abstract":695},"cordis-european-research-council-award-875609","HD-MEA-based Neuronal Assays and Network Analysis for Phenotypic Drug Screenings","In order to overcome the limitations of existing methods for phenotypic drug screening, we propose to develop accurate, label-free, functional neuronal assays for phenotypic\u002Ffunctional drug screening in vitro. These assays will rely on the primary readout of neurons - their electrical signals. We propose to translate and commercialize the assessment of characteristic electrophysiological features of subcellular neuronal components, individual neurons and neuronal networks, all of which can be ob",{"id":697,"funder":7,"programme":8,"title":698,"piName":10,"institution":699,"country":24,"year":13,"amount":14,"abstract":700},"cordis-european-research-council-award-875488","MRI toolkit for in vivo fat virtual biopsy","KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)","In 2015, four million people worldwide died because of the aftermaths of obesity (7% of total deaths), and in 2030, half of humankind is expected to be overweight. Lifestyle interventions in subjects with obesity can prevent the development of obesity-induced metabolic dysfunction but need personalization in order to become effective for diabetes and cardiovascular disease prevention. Visceral adiposity and adipocyte hypertrophy are phenotypes strongly linked to metabolic dysfunction in subjects",{"id":702,"funder":7,"programme":8,"title":703,"piName":10,"institution":115,"country":116,"year":13,"amount":14,"abstract":704},"cordis-european-research-council-award-899573","Assessing the technical and business feasibility of Callose Enriched Plant Biomass as a solution for improving Biorefinery Industry processes and profit margins","BioBiorefineries are facing a positive economic outlook due to the ever-growing concerns for climate change, which is triggering demand towards carbon neutral materials and energy derived from renewable sources. However, the growth of the industry is hampered by their low profit margins and additional investments and innovations are needed to improve process efficiency.The key problem in migrating towards green production is the biomass recalcitrance, which is known to be a major bottleneck in t",{"id":706,"funder":7,"programme":8,"title":707,"piName":10,"institution":708,"country":24,"year":13,"amount":14,"abstract":709},"cordis-european-research-council-award-862005","Putting Offence Prevention into Practice","UNIVERSITAT KONSTANZ","Our advanced ERC grant MemoTV (Memories of Trauma and Violence) confirmed and expanded upon previous research demonstrating that early trauma history and future violent behaviour are closely associated.  However, public health and community violence prevention programs continue to overlook the need to address underlying trauma among perpetrators. MemoTV uncovered that aggressive behavior is fuelled by two cycles of violence, one traumatic\u002Faversive and one appetitive\u002Fappealing.  Based on this kno",{"id":711,"funder":7,"programme":8,"title":712,"piName":10,"institution":500,"country":239,"year":13,"amount":14,"abstract":713},"cordis-european-research-council-award-954332","Very High Energy Electrons for RadioTherapy (VHERAPY)","Very High Energy Electrons (VHEE) as those produced by compact laser plasma accelerators are ideal candidate in radiotherapy (RT). The corresponding dose distribution of the already produced low divergence and quasi-monoenergetic electron beam portends significant potential to treat deep tissue tumors, due to VHEE’s narrow radial dose deposition profile and long penetration distance. Our technological breakthrough is creating VHEE beam suitable for radiation therapy with a single laser and in re",{"id":715,"funder":7,"programme":8,"title":716,"piName":10,"institution":115,"country":116,"year":13,"amount":14,"abstract":717},"cordis-european-research-council-award-862011","Diagnostic autoantibody assay to stratify bone marrow failure diseases","Bone marrow failure syndromes (BMFS) such as aplastic anaemia (AA) are a heterogenous group of rare diseases that manifest as loss of red and white blood cells. In these potentially life-threatening diseases, blood producing stem cells may be inherently defective or become destroyed due to acquired cause. Diagnostic difficulties of BMFS constitute a significant clinical problem as the diagnosis takes long, and misdiagnosis may lead to inappropriate management with serious side effects. In our ER",{"id":719,"funder":7,"programme":8,"title":720,"piName":10,"institution":721,"country":30,"year":13,"amount":14,"abstract":722},"cordis-european-research-council-award-899896","Topological Insulator-Based Spin Orbit Torque MEMories","FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA","SOTMEM addresses the growing need for scalable ultrafast non-volatile memories (NVM) to improve the reliability of logic circuitry and to reduce the ever increasing power consumption and energy loss in microprocessors. Major technology actors and end-user companies are developing magnetic RAM (MRAM) as it is recognized as one of the most promising emerging NVMs. However, mainstream MRAM, relying on spin transfer torque, suffers from limited speed, and reliability and degradation issues. These th",{"id":724,"funder":7,"programme":8,"title":725,"piName":10,"institution":726,"country":70,"year":13,"amount":14,"abstract":727},"cordis-european-research-council-award-875297","Non-invasive prenatal diagnostics – Isolation of circulating trophoblast cells using a malaria protein","KOBENHAVNS UNIVERSITET","Placental biopsies are associated with high risk of miscarriage. Current non-invasive tests are not very precise. The malaria protein VAR2CSA has been evoluationary refined to bind specifically to human placent cells. This causes the syndrom placental malaria in pregnant women. Recombinant VAR2CSA binds with high specificity to syncytiotrophoblasts in the placenta as well as placental cell lines. Using this knowledge we have developed a powerful tool which captures circulating trophoblast from a",{"id":729,"funder":7,"programme":8,"title":730,"piName":10,"institution":731,"country":732,"year":13,"amount":14,"abstract":733},"cordis-european-research-council-award-875671","Routing Attack Vulnerability Evaluation for Networks","IDRYMA TECHNOLOGIAS KAI EREVNAS","EL","The Internet is a critical infrastructure that is composed of The Internet is a critical infrastructure that is composed of tens of thousands of networks and is required to work reliably 24\u002F7. An integral functionality to achieve this is stable, efficient and secure routing of data traffic across several network domains. The current inter-domain routing protocol, BGP, facilitates the exchange of control-plane information (i.e., reachability of Internet resources over network paths) in a scalable",{"id":735,"funder":7,"programme":8,"title":736,"piName":10,"institution":737,"country":30,"year":13,"amount":14,"abstract":738},"cordis-european-research-council-award-899906","Ready-to-use cell culture plates for gut 3D models","FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA","3D cell culture models are considered the next-generation in vitro models. Several efforts are being devoted to better mimic human physiology and predict drug efficacy. In case of the intestinal tissue models, the 3D architecture of the intestinal tissue and the soft mechanical properties have been identified as key factors to obtain models with improved predictive capacities. However, there is a lack of low-cost and ease-to-use intestinal tissue models that encompass both elements. In the COMIE",{"id":740,"funder":7,"programme":8,"title":741,"piName":10,"institution":398,"country":105,"year":13,"amount":14,"abstract":742},"cordis-european-research-council-award-899858","A diagnostic test for cochlear synaptopathy in humans","The CochSyn-test aims to diagnose the first signs of permanent hearing damage with a 10-15 min clinical hearing- screening test. The test quantifies cochlear synaptopathy, i.e. damage to the cochlear auditory-nerve fiber synapses due to ageing, noise-exposure or ototoxicity, with a non-invasive auditory test. Because synaptopathy is associated with reduced speech intelligibility and occurs before the audiogram shows signs of hearing damage, our test is more sensitive than the audiogram (present ",{"id":744,"funder":7,"programme":8,"title":745,"piName":10,"institution":746,"country":36,"year":13,"amount":14,"abstract":747},"cordis-european-research-council-award-875410","A Diagnostic Testing Package for Childhood Synaesthesia","THE UNIVERSITY OF SUSSEX","People with the genetic trait of synaesthesia experience phantom colours, sounds, tastes, and other unusual sensations. These are triggered by everyday activities like reading or listening to music. Importantly, synaesthesia is comorbid with health conditions including anxiety disorder and autism, and has a known impact on education. Although there are widely available tests for diagnosing synaesthesia in adults, there are none for children - despite its relatively wide impact (307 million synae",{"id":749,"funder":7,"programme":8,"title":750,"piName":10,"institution":751,"country":12,"year":13,"amount":14,"abstract":752},"cordis-european-research-council-award-899888","Aerial Release of Mosquitoes","CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LEDEVELOPPEMENT - C.I.R.A.D. EPIC","MOSQUAREL (Aerial Release of Mosquitoes)The REVOLINC project (ERC Consolidator grant no. 682387) aims at developing environmentally-friendly alternatives to fight insects invasions through the development of biological technologies to control three types of pest insects (mosquitoes, tsetse flies and Mediterranean fruit flies), two of which are presently invading Europe. We want to improve the « sterile insect technique » which consists in mass rearing male insects, sterilizing them by radiation ",{"id":754,"funder":7,"programme":8,"title":755,"piName":10,"institution":756,"country":36,"year":13,"amount":14,"abstract":757},"cordis-european-research-council-award-957506","Dynamically augmented navigation system","THE ROYAL VETERINARY COLLEGE","The need to know the precise location of individuals has become ubiquitous. Systems currently used for tracking humans and animals depend on global navigation satellite systems (GNSS eg GPS, Galileo) developed for aircraft, cars and boats, and do not provide reliable position information in conditions where GNSS is inaccurate or unavailable. For our research into locomotion of free-ranging animals, we developed a dynamically-augmented sensor system of higher integrity than GNSS alone. Currently,",{"id":759,"funder":7,"programme":8,"title":760,"piName":10,"institution":280,"country":250,"year":13,"amount":14,"abstract":761},"cordis-european-research-council-award-899921","Towards the use of IgY antibodies as alternative therapeutics","The increased occurrence of antibiotic-resistant pathogens is a critical concern corresponding to economic and societal challenges of high priority. Antimicrobial resistance (AMR) is responsible for 33,000 deaths per year, while bringing €1.5 billion per year in healthcare costs and productivity losses to the EU. Current solutions (biopharmaceuticals) are highly expensive and very few tackle the AMR scenario. Therefore, new approaches to tackling AMR focusing on low cost and relatively low time-",{"id":763,"funder":7,"programme":8,"title":764,"piName":10,"institution":765,"country":36,"year":13,"amount":14,"abstract":766},"cordis-european-research-council-award-963843","Nanostar Sieving for Oligonucleotide Therapeutics","EXACTMER LIMITED","Since the Nobel Prize winning discovery of small interfering RNA its specificity and selectivity have driven the pharmaceutical industry to design 15- to 25-mer oligonucleotide analogues as a new class of drugs. These offer exciting new therapeutic possibilities for example in rare diseases, but also large patient population indications including cardiovascular disease, and viral pandemics such as Covid-19. However, the high cost and limited scalability of manufacturing these complex polymeric m",{"id":768,"funder":7,"programme":8,"title":769,"piName":10,"institution":295,"country":36,"year":13,"amount":14,"abstract":770},"cordis-european-research-council-award-890644","A new high-performance aqueous lubricant formulation for soft bio-contact surfaces","In the AquaLub project, we will translate an innovative aqueous lubricant technology, developed in the context of the ERC project LubSat, towards commercial applications. The technological focus is on an electrostatically-driven macromolecular self-assembly of naturally occurring proteins. Commercial aqueous lubricants market is significantly growing ($22 billion by 2025) with broad range of personal care and institutional care applications to enhance hydration and alleviate dryness-related path",{"id":772,"funder":7,"programme":8,"title":773,"piName":10,"institution":774,"country":775,"year":13,"amount":14,"abstract":776},"cordis-european-research-council-award-875649","Prototyping emerging bio-based products from lignocellulose by zero-waste pathways","UNIVERSITAET GRAZ","AT","The need: The dwindling fossil resources and their increasing price together with concerns related to greenhouse gas emissions and environmental pollution necessitate an urgent transition to the use of renewable starting materials and the fundamental change of our manufacturing practices to cleaner, more sustainable production routes.The challenge: Existing approaches for bio-based production routes are complex and costly, while oftentimes offering limited or no increase in quality over conventi",{"id":778,"funder":7,"programme":8,"title":779,"piName":10,"institution":780,"country":36,"year":13,"amount":14,"abstract":781},"cordis-european-research-council-award-874454","Children’s Photography Archive: a curriculum for child-authored, multimodal citizenship education in primary schools","GOLDSMITHS' COLLEGE","The Children’s Photography Archive (CPA beta) is the first archive in the world of its kind, featuring the photographs of child photographers. Our proposal is to test the scaling up of the CPA for the creation of evidence-based and openly accessible methodologies and learning resources for a child-authored, multimodal citizenship curriculum in primary schools. The social innovation grows out of our ERC-funded research (the 'CONNECTORS STUDY') on the relationship between childhood and public life",{"id":783,"funder":7,"programme":8,"title":784,"piName":10,"institution":785,"country":42,"year":13,"amount":14,"abstract":786},"cordis-european-research-council-award-963463","ALl optical signal recovery by Photonic neural network Integrated in a transceiver module","UNIVERSITA DEGLI STUDI DI TRENTO","ALPI aims at the integration of a photonic neural network within an optical transceiver to increase the transmission capacityof the optical link. Based on a deep learning approach, the new compact device provides real time compensation of fibernonlinearities which degrade optical signals. In fact, the tremendous growth of transmission bandwidth both in opticalnetworks as well as in data centers is baffled by the optical fiber nonlinear Shannon capacity limit. Nowadays, computationalintensive app",{"id":788,"funder":7,"programme":8,"title":789,"piName":10,"institution":218,"country":24,"year":13,"amount":14,"abstract":790},"cordis-european-research-council-award-957496","Fatty liver Nano-\u002FAntibody Therapy - (FAITH)","Changes in life-style and nutrition have increased the incidence of obesity\u002Foverweight and metabolic syndrome resulting in a pathology called Non-alcoholic fatty liver disease (NAFLD). Currently, 130 million people in Western countries have NAFLD and this number is constantly increasing. A significant number of patients develop non-alcoholic steatohepatitis (NASH), fibrosis and subsequently liver cancer. At the same time no efficient therapeutics exist to treat NASH or NASH-liver cancer transiti",{"id":792,"funder":7,"programme":8,"title":793,"piName":10,"institution":244,"country":154,"year":13,"amount":14,"abstract":794},"cordis-european-research-council-award-899535","The electrochemical synthesis of hydrogen peroxide","This proposal aims at determining the market value of hydrogen peroxide (HP) that is produced via our electrochemical methods that have been developed as part of the ERC-StG Cu4Energy project. HP is often shipped, stored and handled in very concentrated and therefore dangerous form, and used in a very diluted form in many products such as stain removers and disinfectants. Our method allows for production of HP in low and safe concentrations and in a continuous fashion and therefore allows produc",{"id":796,"funder":7,"programme":8,"title":797,"piName":10,"institution":798,"country":250,"year":13,"amount":14,"abstract":799},"cordis-european-research-council-award-862545","Antibody-based IL-7R targeted therapies","INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES","Acute lymphoblastic leukemia (ALL), a highly aggressive hematological cancer, is the most frequent childhood malignancy and the second most common acute leukemia in adults. The use of risk-adjusted multi-agent intensive chemotherapy has led to a remarkable improvement in treatment outcome of pediatric cases, with more than 80% of children with ALL being alive and disease-free at 5 years. However, a significant number of relapses still occur, whose prognosis is dismal, and the intensive regimens ",{"id":801,"funder":7,"programme":8,"title":802,"piName":10,"institution":803,"country":30,"year":13,"amount":14,"abstract":804},"cordis-european-research-council-award-957491","Optical device to measure the density of the macular pigment in the human eye","UNIVERSIDAD DE MURCIA","Age-related macular degeneration (AMD) is a leading cause of blindness in Europe. Since there is a lack of effective treatment modalities, prevention is of signficant importance. There are some evidences that nutritional counseling or intervention might reduce AMD incidence or slow down its progression. In particular, dietary modification or supplement intake may facilitate the increase of the retinal carotenoids lutein (L) and zeaxanthin (Z) that form the macular pigment (MP) and prevent neovas",{"id":806,"funder":7,"programme":8,"title":807,"piName":10,"institution":659,"country":36,"year":13,"amount":14,"abstract":808},"cordis-european-research-council-award-899908","Graphene-based adaptive thermal shields for satellites","As satellites get more miniaturized, they place unique thermal control challenges. Because of their low masses, they experience large temperature variations in the very tough and rapidly varying outer space environment. However, due to the lack of efficient active infrared materials, dynamic control of thermal radiation from satellites has been a challenge. As a result of the research undertaken in the SmartGraphene (ERC-CoG-2016-682723), we have successfully demonstrated graphene-based active i",{"id":810,"funder":7,"programme":8,"title":811,"piName":10,"institution":812,"country":775,"year":13,"amount":14,"abstract":813},"cordis-european-research-council-award-963875","Isotope-labeled amino acids – Providing solutions to complex biological questions","UNIVERSITAT WIEN","Isotope-labeled amino acids are highly valuable and versatile tools to tackle complex biological questions and to accelerate research and therapeutic development. Current production processes are, however, low-yielding, expensive and time-intensive, and cannot be applied to all amino acids, leading to missed therapeutic opportunities and inefficient use of resources. We have addressed these limitations and developed an innovative and more efficient method to produce such isotope-labeled amino ac",{"id":815,"funder":7,"programme":8,"title":816,"piName":10,"institution":817,"country":818,"year":13,"amount":14,"abstract":819},"cordis-european-research-council-award-899259","Coiled-coil mediated exonuclease tethering technology for the enhancement of CRISPR gene editing","KEMIJSKI INSTITUT","SI","The discovery and implementation of CRISPR technology represents a milestone for biotechnology and life sciences in general as the genomes of virtually all organisms can be modified by this technology and have already resulted in billions of euros of added value. With this technique, selected genes can be rather easily inactivated (knock out), which is one of the key applications of CRISPR for cell-based therapy and industrial biotechnology. Any improvement of the efficiency of CRISPR therefore ",{"id":821,"funder":7,"programme":8,"title":822,"piName":10,"institution":505,"country":105,"year":13,"amount":14,"abstract":823},"cordis-european-research-council-award-893462","Automatic measurement of speech understanding using EEG","In medicine, it is often essential to know to what extent a person can understand speech. Current methods to measure speech understanding involve playing specially crafted sentences to the person, letting the person repeat them, and scoring the result manually. This requires active participation of the person, specialised speech material, and is labour intensive. We present a system to measure speech understanding fully automatically. We record brain responses while the person listens to a recor",{"id":825,"funder":7,"programme":8,"title":826,"piName":10,"institution":827,"country":36,"year":13,"amount":14,"abstract":828},"cordis-european-research-council-award-899863","Preventing and reversing neuroinflammatory brain damage using local expansion of regulatory T cells","THE BABRAHAM INSTITUTE","A proposal to use local IL2 delivery via a viral vector to prevent and reverse the inflammatory damage that happens to the brain during neuroinflammatory diseases as diverse as traumatic brain injury, Multiple Sclerosis and Alzheimer's Disease. In TissueTregs we identified and characterised a brain-resident regulatory T cell population, with high expression of anti-inflammatory and reparative proteins. A synthetic circuit for deliver IL2 to the brain expanded this population, without any off-tar",{"id":830,"funder":7,"programme":8,"title":831,"piName":10,"institution":832,"country":24,"year":13,"amount":14,"abstract":833},"cordis-european-research-council-award-957534","Ultra-high energy storage Li-anode materials","HUMBOLDT-UNIVERSITAET ZU BERLIN","Lithium (Li) ion batteries – present in all consumer electronics and battery-powered vehicles – are produced in a capital and know-how intensive way, in particular during the initial steps of materials synthesis and cell manufacturing. The anodes of Liion batteries are currently prepared by mixing an ink of binders, solvents, silicon (Si) nanoparticles and graphite under strictly controlled conditions (order, timing, temperature), and they undergo several steps like application of the slurry to ",{"id":835,"funder":7,"programme":8,"title":836,"piName":10,"institution":699,"country":24,"year":13,"amount":14,"abstract":837},"cordis-european-research-council-award-963904","BoneScreen: Opportunistic Osteoporosis Screening in Computed Tomography","Worldwide, an osteoporotic fracture occurs every three seconds; most of them in Europe, where the economic burden has been estimated at €37 billion per year and lost years of life surpass most major cancers. This is hard to comprehend, given that osteoporosis is a preventable, treatable disease, if diagnosed at an early stage. As current state-of-the-art screening methods are neither sufficiently available nor accurate, there is an urgent need for readily available and accurate screening systems",{"id":839,"funder":7,"programme":8,"title":840,"piName":10,"institution":238,"country":239,"year":13,"amount":14,"abstract":841},"cordis-european-research-council-award-899839","A cost-effective, out-of-the-box photon counting platform for multi-photon in vivo microscopy applications","Multi-photon microscopy is the gold-standard brain imaging approach to study the brain and other organs in action and is used across hundreds of laboratories worldwide. The current attempts to imaging increasingly large tissue volumes pushed multi-photon microscopy into the photon-deprived regime (i.e. the dim conditions that result from moving faster allowing collection of less photons per pixel\u002Fvoxel). Under these condition, the relative few photons detected can be lost in the electronics nois",{"id":843,"funder":7,"programme":8,"title":844,"piName":10,"institution":203,"country":36,"year":13,"amount":14,"abstract":845},"cordis-european-research-council-award-957514","Metal-Organic Hydrogels for Efficient Drug Delivery (MOHEDD)","The treatment of glioblastoma – the most common, aggressive and lethal type of brain cancer with survival rated below 14% – requires novel and improved drug delivery systems to overcome the drawback of state-of-the-art local chemotherapy by using Gliadel wafers. MOHEDD aims to evaluate the feasibility of advanced nanoMOFs and hydrogel hybrids for controlled drug delivery into the commercial stage, with the idea of accelerating their access to the market as highly efficient delivery vehicles for ",{"id":847,"funder":7,"programme":8,"title":848,"piName":10,"institution":849,"country":30,"year":13,"amount":14,"abstract":850},"cordis-european-research-council-award-899209","Indigenous Climate Change Impacts Observation Network","UNIVERSITAT AUTONOMA DE BARCELONA","The Local Indicators of Climate Change Impacts project (771056-LICCI-ERC-2017-COG) explores the potential of Indigenous and local knowledge (ILK) to contribute to climate research, but only tangentially addresses the marginalized position faced by Indigenous Peoples and local communities (IPLC) to bring their knowledge and perspectives to climate change research and policy fora. This PoC will bring IPLC knowledge and perspectives to climate change research and policy fora by 1) engage with IPLC ",{"id":852,"funder":7,"programme":8,"title":853,"piName":10,"institution":854,"country":42,"year":13,"amount":14,"abstract":855},"cordis-european-research-council-award-875031","Engineering and commercialization of a smart camera with on-chip image processing for head- and eye-tracking in laboratory animals","SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE","Rodents have become very popular models of cognitive functions, such as perception, memory and decision-making. Understanding the neuronal substrates of these processes requires performing neurophysiological recordings in awake animals, engaged in complex behavioral tasks. This, in turn, calls for tracking in real-time the motor behavior of the animal, to relate it to the underlying brain activity. Custom, as well as commercial, solutions exist that allows tracking basic behaviors in rodents – e",174,{"programme":8,"total":858,"withPiName":859,"firstYear":860,"lastYear":861,"countryCount":862,"perYear":863,"topInstitutions":901,"topCountries":969},2347,7,2014,2027,31,[864,866,869,871,874,877,880,881,884,887,890,893,896,899],{"year":860,"count":865},13,{"year":867,"count":868},2015,142,{"year":870,"count":868},2016,{"year":872,"count":873},2017,200,{"year":875,"count":876},2018,160,{"year":878,"count":879},2019,176,{"year":13,"count":856},{"year":882,"count":883},2021,120,{"year":885,"count":886},2022,198,{"year":888,"count":889},2023,231,{"year":891,"count":892},2024,237,{"year":894,"count":895},2025,265,{"year":897,"count":898},2026,264,{"year":861,"count":900},25,[902,905,908,911,914,917,920,923,926,928,930,933,936,939,941,944,947,949,952,954,956,958,961,964,966],{"name":903,"count":904},"Centre National de la Recherche Scientifique CNRS",84,{"name":906,"count":907},"Weizmann Institute of Science",65,{"name":909,"count":910},"Technion - Israel Institute of Technology",43,{"name":912,"count":913},"The Chancellor Masters and Scholars of the University of Cambridge",42,{"name":915,"count":916},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",41,{"name":918,"count":919},"Fondazione Istituto Italiano di Tecnologia",34,{"name":921,"count":922},"Tel Aviv University",33,{"name":924,"count":925},"Imperial College of Science Technology and Medicine",32,{"name":927,"count":925},"Politecnico di Milano",{"name":929,"count":862},"Institut National de la Sante Et de la Recherche Medicale",{"name":931,"count":932},"Ecole Polytechnique Federale de Lausanne",30,{"name":934,"count":935},"Universiteit Twente",29,{"name":937,"count":938},"The Hebrew University of Jerusalem",28,{"name":940,"count":938},"Universiteit Gent",{"name":942,"count":943},"The Chancellor, Masters and Scholars of the University of Oxford",27,{"name":945,"count":946},"Danmarks Tekniske Universitet",24,{"name":948,"count":946},"Vib Vzw",{"name":950,"count":951},"Katholieke Universiteit Leuven",23,{"name":953,"count":951},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",{"name":955,"count":951},"Technische Universitaet Muenchen",{"name":957,"count":951},"Technische Universiteit Delft",{"name":959,"count":960},"The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undivided Trinity of Queen Elizabeth Near Dublin",22,{"name":962,"count":963},"Technische Universiteit Eindhoven",21,{"name":965,"count":963},"Universiteit Leiden",{"name":967,"count":968},"Eidgenoessische Technische Hochschule Zuerich",20,[970,972,974,976,978,980,982,984,986,988,990,992,994,996,998,1000,1001,1003,1005,1008,1010,1012,1015,1016,1018],{"name":24,"count":971},299,{"name":30,"count":973},273,{"name":36,"count":975},261,{"name":154,"count":977},254,{"name":42,"count":979},221,{"name":12,"count":981},215,{"name":239,"count":983},191,{"name":105,"count":985},109,{"name":137,"count":987},85,{"name":148,"count":989},72,{"name":775,"count":991},62,{"name":70,"count":993},50,{"name":320,"count":995},48,{"name":116,"count":997},47,{"name":250,"count":999},40,{"name":732,"count":968},{"name":521,"count":1002},19,{"name":675,"count":1004},17,{"name":1006,"count":1007},"CY",12,{"name":233,"count":1009},11,{"name":270,"count":1011},10,{"name":1013,"count":1014},"PL",8,{"name":818,"count":1014},{"name":432,"count":1017},5,{"name":1019,"count":1020},"HR",2]