[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-proof-of-concept-2021":3,"awarded-stats-erc-proof-of-concept":599},{"awarded":4,"total":598},[5,16,20,24,30,35,41,47,51,56,61,65,71,76,81,85,89,93,98,103,109,114,120,125,130,135,141,146,150,154,158,162,167,172,177,183,188,194,200,205,210,215,220,225,230,235,240,244,249,253,258,264,269,274,279,285,290,295,299,303,308,314,319,324,328,333,338,342,348,352,357,363,368,373,377,382,386,392,397,403,408,413,418,424,428,432,437,443,448,453,458,463,468,472,477,482,487,491,496,501,506,510,515,520,524,528,532,536,541,546,551,556,560,565,571,575,579,584,589,593],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-899742","European Research Council","ERC Proof of Concept","Perception Ultrasound for Reassuring Fetal Echo Clinical Trainees",null,"THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","UK",2021,"€150,000","Perception Ultrasound for Reassuring Fetal Echo Clinical Trainees (PURFECT)  builds on the results of ERC Advanced Grant PULSE to develop an AI-assistive system to guide a user to find a standard mid-trimester fetal ultrasound imaging plane. Such a system would provide reassurance to newly qualified sonographers as they begin to perform real-world diagnostic imaging, may support experts perform scanning more efficiently, and would contribute to the desired trend to use ultrasound more widely in ",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":19},"cordis-european-research-council-award-957566","DNA4Science: Citizen-science data collection for ethical data re-use","Isolating genetic markers associated with phenotypes (i.e., diseases and behaviour) is one of the most promising frontiers of scientific discovery. Genetics plays a key role in understanding multiple diseases, holding a promise for medical interventions and drug targets. Attention to genotype measurement has resulted in a neglect of novel and precision phenotypes and novel measurement of other individual and environmental characteristics. Although combined genotype-phenIsolating genetic markers ",{"id":21,"funder":7,"programme":8,"title":22,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":23},"cordis-european-research-council-award-957504","Portable Luminescent Sensor for Volatile Organic Compounds","The LUMIVOCS project will exploit the recently developed luminescent Guest@MOF composite materials, which exhibit unique phototunable properties to engineer a revolutionary sensor device to achieve low concentration ppm-level detection of volatile organic compounds (VOCs). Such a compact VOC sensor could be deployed for toxic VOC detection in industry and sustainability applications, or, for use in diabetes diagnostics in the healthcare and biomedical sectors. Hitherto, none of the commercial VO",{"id":25,"funder":7,"programme":8,"title":26,"piName":10,"institution":27,"country":28,"year":13,"amount":14,"abstract":29},"cordis-european-research-council-award-963929","An innovative family of antibiotics to fight multi-resistant bacteria","INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT","FR","Antibiotic resistant bacteria are rapidly emerging worldwide. This antibiotic resistance crisis is notably connected to the massive misuse of antibiotics and the lack of novel and efficient compounds. With countless structures and properties, natural products including ribosomally synthesized and post-translationally modified peptides (RiPP) are a promising source of antibiotics . However, their development as effective antibiotics faces many challenges related notably to their synthesis, stabil",{"id":31,"funder":7,"programme":8,"title":32,"piName":10,"institution":33,"country":28,"year":13,"amount":14,"abstract":34},"cordis-european-research-council-award-966856","A universally applicable system for direct readout of eukaryotic cell transgenesis with a novel integration-coupled gene expression switch","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","Stable integration of exogenous transgenes in the genome of transfected eukaryotic host cells is essential in many biological, biotechnological and biomedical applications. Naked DNA vectors are increasingly applied for this purpose as an alternative to viral particles due to their low cost, easy production and simplicity of use. However, transgenesis with these vectors remains fundamentally hindered by the impossibility to distinguish integrated transgenes from those remaining in episomal form,",{"id":36,"funder":7,"programme":8,"title":37,"piName":10,"institution":38,"country":39,"year":13,"amount":14,"abstract":40},"cordis-european-research-council-award-966722","High precision material printer for electronics","UNIVERSITA DI PISA","IT","The aim of the PREPRINT project is to obtain the much-needed improvement in terms of resolution of materials printers, in order to achieve the far-reaching goal of fabricating integrated circuits with Large Scale of Integration (LSI, i.e., thousands of transistors, the same level of integration of the first INTEL microprocessors) in printed electronic systems on wearable\u002Fflexible substrates. The number of transistors on a substrate is mainly determined by the resolution of the printing machines,",{"id":42,"funder":7,"programme":8,"title":43,"piName":10,"institution":44,"country":45,"year":13,"amount":14,"abstract":46},"cordis-european-research-council-award-957467","Artificial Intelligence for Smart Cities","TECHNISCHE UNIVERSITAET MUENCHEN","DE","It is estimated that by 2050, 68% of the world population will live in urban areas, according to the United Nations. With the accelerated rhythm of population growth, the expected number of urban citizens in 2050 is close to 6.5 billion (compared to 4.2 billion nowadays). Uncontrolled urbanization  raises a significant problem, the topic of the United Nations Development Programme Goal 11: ensuring sustainable and safe growth of urban areas. This project therefore addresses a global problem. To ",{"id":48,"funder":7,"programme":8,"title":49,"piName":10,"institution":44,"country":45,"year":13,"amount":14,"abstract":50},"cordis-european-research-council-award-963947","Establishing continuous biomarker monitoring for Big Data in fitness and healthcare","Goal of the PoC is to evaluate possible commercial applications of a multi-sensor test strip and the necessary oxygen scavenger that were patented within the ERC starting grant “REDOX SHIELDS”. Such a multi-analyte sensor can be used to calibrate the millions of data points generated by wearables every day to improve the accuracy of non-invasive sensors in a Big Data scheme in fitness and healthcare. The test strip is designed to accurately measure multiple analytes from a tiny drop of blood.",{"id":52,"funder":7,"programme":8,"title":53,"piName":10,"institution":54,"country":28,"year":13,"amount":14,"abstract":55},"cordis-european-research-council-award-899652","On- and offline-Networks for Event Aware Topological detection","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","Imaging methods enabling the acquisition of millions of cell contours have opened the path for improved understanding of development, repair, homeostasis and pathology. The full potential of such imaging methods can only be reached when robust, cost-effective and user-friendly methods are democratized to extract important information from the huge amounts of data generated. Our project aims to implement a disruptive deep-learning based technology, O-NEAT, that uses these masses of data for train",{"id":57,"funder":7,"programme":8,"title":58,"piName":10,"institution":59,"country":12,"year":13,"amount":14,"abstract":60},"cordis-european-research-council-award-957524","SERENITY-X – Accelerating AI","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","The ERC frontier project ADG-670406 develops a novel very high performance tracking calorimeter for the precise measurement of the energy of the particles produced in high-energy collisions. One of the key challenges that we have had to overcome is that of reading out the unprecedented quantity of information that such a calorimeter produces. To address this we have developed a novel, state-of-the-art FPGA based digital platform (SERENITY), including machine learning. We have developed a generic",{"id":62,"funder":7,"programme":8,"title":63,"piName":10,"institution":54,"country":28,"year":13,"amount":14,"abstract":64},"cordis-european-research-council-award-963928","Shape controlled spin-Orbit memories : Fabrication process and Technology transfer","Non-volatility is the main physical feature that fast memories, such as SRAM, are still lacking. Non-volatile memories could increase computing performance while reducing significantly the power consumption. The only viable option for sub-ns nonvolatile memory is the Spin Orbit Torque Magnetic Random Access Memory (SOT-MRAM). The main roadblock towards the integration of the SOT-MRAM is that the reproducible bipolar switching requires the application of a static in plane magnetic field. “Zero-fi",{"id":66,"funder":7,"programme":8,"title":67,"piName":10,"institution":68,"country":69,"year":13,"amount":14,"abstract":70},"cordis-european-research-council-award-963955","Injectable wireless microsensors based on the eAXON technology","UNIVERSIDAD POMPEU FABRA","ES","Within the eAXON project, which is funded by an ERC CoG, we are developing a technology for neuroprosthetics which consists of wireless microstimulators whose operation is based on rectification of galvanically conducted bursts of high frequency current. In addition to the microstimulators technology, we have conceived and protected a technology for the development of implantable sensing systems with an unprecedented level of minimal invasiveness. The sensing technology consists of a very thin i",{"id":72,"funder":7,"programme":8,"title":73,"piName":10,"institution":74,"country":69,"year":13,"amount":14,"abstract":75},"cordis-european-research-council-award-963954","ORganic thermoelectric GEnerators to power precision VIticulture sensor NEtworks","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","ORGEVINE aims to reduce water and phytosanitary chemicals usage as well as enhancing production yield in the wine industry by developing a network of wireless autonomous sensors that will provide real time images of key field parameters such as temperature and humidity. This will be achieved by taking our patented non-toxic thermoelectric materials into prototype organic thermoelectric generators (OTEGs) that will power the low-cost sensors. By taking advantage of the ubiquitous renewable energy",{"id":77,"funder":7,"programme":8,"title":78,"piName":10,"institution":79,"country":69,"year":13,"amount":14,"abstract":80},"cordis-european-research-council-award-899334","Targeting the cancer stem cell (CSC) metabolism with designed, reactive metal complexes","UNIVERSIDAD DE SANTIAGO DE COMPOSTELA","Designed, bulky metal complexes with a labile coordination position react with accessible guanines at G4 DNA quadruplexes, promoting changes in their conformation and function. Importantly, we have found that this selective reactivity leads to very interesting biological effects. In particular, some of these compounds are able to suppress the “stem”-like character of cancer stem cells, apparently by deterring their mitochondrial respiration. Preliminary experiments, including in vivo assays, con",{"id":82,"funder":7,"programme":8,"title":83,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":84},"cordis-european-research-council-award-963953","Supramolecular attack particles to prevent cancer recurrence","Supramolecular attack particles (SMAPs) are proteinaceous particles ~120 nm in diameter released from cytotoxic T cell and natural killer cells.  The particles have a core of cytotoxic proteins including perforin andgranzymes enveloped in a dense shell of glycoproteins including thrombospondin-1, which provides specificity for SMAP mediated killing. SMAPs released from T-cells are stable for at least 24 hours and can kill target cells autonomously.  The human cell line NK92 secretes SMAPs based ",{"id":86,"funder":7,"programme":8,"title":87,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":88},"cordis-european-research-council-award-966757","Translation of adaptive optical microscopy expertise to the commercial domain","Adaptive optics (AO) is an important technology for high-resolution microscopy that overcomes imaging problems when focusing inside biological specimens. Through the ERC Advanced Grant AdOMiS we have developed and experimentally validated new, broadly applicable AO tools that make integration of this technology more practical for a range of different microscopy techniques. We have also accumulated significant know-how about effective implementation of this technology. The challenge now is to tra",{"id":90,"funder":7,"programme":8,"title":91,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":92},"cordis-european-research-council-award-966795","Teaching Race, Belonging, Empire and Migration","Issues of race, belonging, empire, and migration have been at the foreground of public consciousness globally in recent years. Our collective understanding of history and culture is often unsurprisingly at the centre of this discourse, with the foundational role of school education coming particularly under pressure. Imparting a full and complete understanding of issues of race and human mobility is in our collective interest, since the resulting diversity and social inclusion generate a range o",{"id":94,"funder":7,"programme":8,"title":95,"piName":10,"institution":96,"country":39,"year":13,"amount":14,"abstract":97},"cordis-european-research-council-award-966758","Operando-Spectroscopy Annular Reactor for Spectro-kinetic Analysis in Heterogeneous Catalysis","POLITECNICO DI MILANO","The big challenge facing the chemical and related industries in the 21st century is the transition towards more sustainable manufacturing processes that efficiently use raw materials\u002Fenergy and eliminate waste. Within this framework, catalysis engineering is recognized as the most important key enabling technology that has a substantial impact on key manufacturing sectors such as petroleum, energy, chemicals, pharma and food industry (about $ 10 trillion of the world’s Gross National Product) an",{"id":99,"funder":7,"programme":8,"title":100,"piName":10,"institution":101,"country":45,"year":13,"amount":14,"abstract":102},"cordis-european-research-council-award-966733","Safety Analysis of Concurrent Systems","RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN","Software faults that evade testing can have serious consequences, not sparing economic damages or human losses. Recent developments towards multi-core processors have led to the increased usage of concurrency to utilize the hardware's full potential. While helping to make software ever more capable, this further complicates the already laborious and time-consuming challenge of software testing. Not only tremendously increasing the computational effort needed to automatically find concurrency bug",{"id":104,"funder":7,"programme":8,"title":105,"piName":10,"institution":106,"country":107,"year":13,"amount":14,"abstract":108},"cordis-european-research-council-award-963945","Shaped Hybrid Forward Error Correction","TECHNISCHE UNIVERSITEIT EINDHOVEN","NL","Next-generation optical and wireless communications require high-performance, high-speed, and low-power consumption error decoding structures. These requirements cannot be satisfied by VLSI-implemented soft-decision or hard-decision forward error correction (FEC), as both bear crucial limitations. The entire telecommunication network value chain is in distress. Designers, device manufacturers and system level integrators are trying to find solutions via costly and time-consuming approaches that ",{"id":110,"funder":7,"programme":8,"title":111,"piName":10,"institution":112,"country":39,"year":13,"amount":14,"abstract":113},"cordis-european-research-council-award-966841","Temperature InduCed K+ channel as a tool to treat neuropathic pain","UNIVERSITA DEGLI STUDI DI MILANO","Non-invasive Control of Neuronal Activity can in principle contribute to the medical treatment of pathologic states in which the electrical activity of neurons is impaired, as in seizures and in chronic pain (CP). To this end, we are developing and validating proteins regulated by non-toxic external stimuli that freely penetrate tissues. TICK (Temperature InduCed K+ channel) is a K+ Channel reversibly regulated by Temperature in a very narrow range (37-40 °C). The open channel drives a large K+ ",{"id":115,"funder":7,"programme":8,"title":116,"piName":10,"institution":117,"country":118,"year":13,"amount":14,"abstract":119},"cordis-european-research-council-award-963986","Highly multiplexed, quantitative epigenetic profiling","KAROLINSKA INSTITUTET","SE","Here, we develop a highly multiplexed, quantitative, ChIP-Seq technology (hmqChIP-Seq) for commercial exploitation in high-throughput profiling of epigenetic drug on- and off-target effects. Screening efficacy and toxicology of drug candidates in early stages of development has been recognized to be an essential part of drug screening. 90% of all Phase I drug candidates do not reach FDA approval and it is estimated that a quarter of failures relates to unexpected toxicity in humans. This is stun",{"id":121,"funder":7,"programme":8,"title":122,"piName":10,"institution":123,"country":45,"year":13,"amount":14,"abstract":124},"cordis-european-research-council-award-957442","Collaborative AI Counters Hate","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","Online hate speech and disinformation have emerged as a major problem for democratic societies worldwide. Governments, companies and civil society groups have responded to this phenomenon by increasingly turning to Artificial Intelligence (AI) as a tool that can detect, decelerate and remove online extreme speech. However, such efforts confront many challenges. One of the key challenges is the quality, scope, and inclusivity of training data sets. The second challenge is the lack of procedural g",{"id":126,"funder":7,"programme":8,"title":127,"piName":10,"institution":128,"country":28,"year":13,"amount":14,"abstract":129},"cordis-european-research-council-award-963895","Magnetic alignment for high precision 3D assembly","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","In microelectronics, 3D integration and assembly definitely appears as a very efficient option to achieve highly integrated chips. It offers major benefits such as combining heterogeneous technologies, combining high-performance and low-power chips,  increasing data transfer bandwidth in memory above logic circuits, etc. 3D assembly is realized by bonding two wafers or chips face to face on a wafer. In this bonding process, the number of interchips interconnects is limited by the accuracy of the",{"id":131,"funder":7,"programme":8,"title":132,"piName":10,"institution":133,"country":107,"year":13,"amount":14,"abstract":134},"cordis-european-research-council-award-966788","BioAlkane","TECHNISCHE UNIVERSITEIT DELFT","BioAlkane will provide the proof-of-concept for the economic and ecological feasibility of a new concept for the valorisation of waste fatty acids as alkanes useful for the energy and transportation sector. Using a new catalyst class (photodecarboxylases) we will establish a completely new method for the conversion of fatty acids into alkanes (instead of the traditionally used fatty acid methyl esters). Using a novel photoreactor design, we will overcome current limitations of photobiocatalysis ",{"id":136,"funder":7,"programme":8,"title":137,"piName":10,"institution":138,"country":139,"year":13,"amount":14,"abstract":140},"cordis-european-research-council-award-966842","Printable Strain Sensors - Nanomaterial based Inks for High Performance  Sensing Applications","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","IE","Strain gauges are devices that are used to measure a variety of forces. The broad nature of these devices means that they have applications in industries ranging from construction and aerospace to medical and automotive fields. Our project looks to develop a new approach to strain sensing devices by utilizing the unique properties of nanomaterial based composites. Through the expertise gained through the previously awarded ERC FUTURE-PRINT grant we look to develop the next generation of commerci",{"id":142,"funder":7,"programme":8,"title":143,"piName":10,"institution":144,"country":39,"year":13,"amount":14,"abstract":145},"cordis-european-research-council-award-966623","3D Autonomous 2-PhoTon Optogenetics MICroscopy","UNIVERSITA DEGLI STUDI DI FIRENZE","Brain activity relies on complex interactions among large populations of neurons located in different brain regions. Understanding the relationships between these specific areas and disentangling the contributions of individual neurons to circuit function is an essential step to understand brain functioning. To elucidate the connection between brain activation and behaviour outcome, it is necessary to establish specific experimental strategies that allow to record and externally control neuronal",{"id":147,"funder":7,"programme":8,"title":148,"piName":10,"institution":54,"country":28,"year":13,"amount":14,"abstract":149},"cordis-european-research-council-award-963967","Fast and accurate enantiomeric and chemical analysis","Chiral molecules exist as two forms, called enantiomers, which are mirror images of each other but which are not superimposable. Living organisms are built upon chiral elementary blocks. Biological processes can thus be extremely sensitive to chirality. Two enantiomers can have different smells or tastes.  More critically, a chiral molecule can have healing properties while its mirror image is a poison. This makes the measurement of enantiomeric excess (EE), which quantifies the relative composi",{"id":151,"funder":7,"programme":8,"title":152,"piName":10,"institution":54,"country":28,"year":13,"amount":14,"abstract":153},"cordis-european-research-council-award-966570","Secure Analytics as Business Services","Big data and data lakes are gold mines for data scientists with tons of applications to finance, medicine, economics, etc. But most of these data are quite sensitive and cannot be widely distributed or even just used without strong protection. One is thus facing the huge dilemma of having to make the choice between highly valuable analytics and privacy. The ERC CryptoCloud project has designed several primitives perfectly well-suited to such situations. They are quite powerful but also highly te",{"id":155,"funder":7,"programme":8,"title":156,"piName":10,"institution":54,"country":28,"year":13,"amount":14,"abstract":157},"cordis-european-research-council-award-966735","Superconducting memristors for memory and neuromorphic applications","The concept we aim a proving is a novel type of electronic device, a redox superconducting memristor, whose functionality is beyond that of binary memories: it shows a continuum of states (instead of just two), and the switching between them can be driven by a sequence of voltage pulses or by visible light illumination.  Furthermore, it is based on high-temperature superconductors, allowing for low-dissipation devices. This concept stems from recent work in the frame of an ERC consolidator grant",{"id":159,"funder":7,"programme":8,"title":160,"piName":10,"institution":133,"country":107,"year":13,"amount":14,"abstract":161},"cordis-european-research-council-award-966720","Graphene to Fight Antimicrobial Resistance","Today, antimicrobial resistance is emerging as a global burden, endangering our lives. Drug-resistant pathogens kill about 25,000 infected people solely in the European Union every year. In the fight against this crisis, rapid Antimicrobial Susceptibility Testing (AST) plays a crucial role. Although effective in discerning the right concentration of antibiotics required to inhibit the growth of a pathogen, conventional AST techniques are not fit for point-of-care, since they are slow and require",{"id":163,"funder":7,"programme":8,"title":164,"piName":10,"institution":165,"country":12,"year":13,"amount":14,"abstract":166},"cordis-european-research-council-award-963898","3D printed elastomers with stereochemically-defined properties","THE UNIVERSITY OF BIRMINGHAM","In most synthetic polymeric materials, control over the mechanical properties of the material is achieved by changing the fundamental chemical structure of the polymer by using monomers with fundamentally different functional groups, chain length or rigidity. In contrast, Nature’s polymers use a more restricted set of building blocks but use additional complexity to the structure−property relationship by leveraging stereochemistry to control the structure and hence properties and function of mat",{"id":168,"funder":7,"programme":8,"title":169,"piName":10,"institution":170,"country":69,"year":13,"amount":14,"abstract":171},"cordis-european-research-council-award-963988","Novel senolytic drugs for the treatment of lung and kidney fibrosis","FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)","SENFIB aims to deliver new drugs for the treatment of fibrotic diseases. Nearly one quarter of the global population will be over the age of 65 by 2050. Populations over 65 suffer from multiple degenerative diseases including tissue fibrosis, estimated to account for upwards of 45% of all-cause mortality. Animal models have demonstrated that senescent cells are causative in many fibrotic diseases including lung (i.e. idiopathic pulmonary fibrosis, IPF), and chronic kidney disease (CKD). Senescen",{"id":173,"funder":7,"programme":8,"title":174,"piName":10,"institution":175,"country":39,"year":13,"amount":14,"abstract":176},"cordis-european-research-council-award-963893","STIMBOY: Your STIMulating BOt","UNIVERSITA CAMPUS BIO MEDICO DI ROMA","Transcranial Magnetic Stimulation (TMS) is a tool to stimulate non-invasively the brain, employed in Research and Clinics (e.g. depression, chronic pain, stroke, dementia, etc).Low spatial resolution, time-consuming rigid protocol and the continuous need of the presence of an expert has dramatically contained TMS research impact and therapeutic diffusion.STIMBOY project objectives are: 1) improve the robot-TMS developed within the ERC RESHAPE project to realize a TMS-droid (STIMBOY) that fulfill",{"id":178,"funder":7,"programme":8,"title":179,"piName":10,"institution":180,"country":181,"year":13,"amount":14,"abstract":182},"cordis-european-research-council-award-874456","An exosome-based therapeutic approach against chronic inflammation","IDRYMA TECHNOLOGIAS KAI EREVNAS","EL","DNA damage triggers the activation of innate immune signaling leading to chronic inflammation and the premature onset of e.g. rheumatoid arthritis, diabetes, metabolic diseases and neurodegenerative disorders in man. Based on our ERC consolidator program DeFiNER, we recently discovered that persistent DNA damage triggers the innate immune system stimulating broad inflammatory and antiviral immune countermeasures that lead to chronic inflammation and the premature onset of severe metabolic compli",{"id":184,"funder":7,"programme":8,"title":185,"piName":10,"institution":186,"country":69,"year":13,"amount":14,"abstract":187},"cordis-european-research-council-award-957527","A user-friendly approach to widespread gas monitoring","UNIVERSITAT DE BARCELONA","Stick&Sense aims at making gas monitoring technology accessible to everyone. In a moment when society is more and more aware about the risks related to airborne pollution, the market is failing at providing a gas monitoring solution suitable for a massive, widespread use. Stick&Sense addresses, all-in-one, the main limitations of existing technologies: it is a disruptive one-stop solution capable of offering low cost, low complexity, high selectivity, good durability and broad detection range. S",{"id":189,"funder":7,"programme":8,"title":190,"piName":10,"institution":191,"country":192,"year":13,"amount":14,"abstract":193},"cordis-european-research-council-award-963639","Targeting Tau-induced cognitive decline with antisense oligonucleotides to synaptogyrin-3","VIB VZW","BE","Tauopathies (that include Alzheimer’s disease) are characterized by hyperphosphorylation or mutations in the microtubuleassociated protein Tau. This reduces the affinity of Tau to bind microtubules and increases the levels of soluble detached Tau in neurons. Previous ERC-supported work from my lab showed that pathogenic Tau accumulates at pre-synaptic terminals and clusters synaptic vesicles in mouse and fly Tauopathy models and in Alzheimer patient brain samples. This pre-synaptic Tau reduces v",{"id":195,"funder":7,"programme":8,"title":196,"piName":10,"institution":197,"country":198,"year":13,"amount":14,"abstract":199},"cordis-european-research-council-award-957440","Scalable fabrication process for quantum-circuit refrigerators","AALTO KORKEAKOULUSAATIO SR","FI","Quantum computers are emerging as disruptive computational devices. A significant obstacle in scaling up quantum computers is the fact that they exhibit very low tolerance against external perturbations. This means that the quantum processors need to be extremely well isolated from all sources of dissipation during their quantum coherent operation. This generates an increased steady-state temperature and triggers long natural initialization times, i.e., long reset time for the quantum memory. Th",{"id":201,"funder":7,"programme":8,"title":202,"piName":10,"institution":203,"country":12,"year":13,"amount":14,"abstract":204},"cordis-european-research-council-award-966760","Photon-Multiplication to Boost Si Photovoltaic Power Conversion Efficiency","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","Photovoltaics (PVs) cells will play a major role in the worldwide transition to more sustainable sources of energy. There has been a vast scale up in the deployment of PV cells driven by the drastic price reduction of Si photovoltaics (Si-PVs). It is now widely accepted that increases in PV efficiency are key to pushing PV deployment further and continuing to lower costs. However, after decades of research and development Si-PVs are approaching the theoretical limit for power conversion efficien",{"id":206,"funder":7,"programme":8,"title":207,"piName":10,"institution":208,"country":107,"year":13,"amount":14,"abstract":209},"cordis-european-research-council-award-963934","Interventional SPECT\u002FCT for Radioembolization","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","Current SPECT\u002FCT scanners are not suitable for guiding interventional procedures involving the administration of radionuclides in a patient. These scanners are too large and not flexible enough to smoothly integrate into the intervention room. Hence, the radionuclide distributions obtained in these procedures can currently only be evaluated after the interventional procedure is finished, resulting in sub-optimal treatment outcomes. To address this problem, we have developed a SPECT\u002FCT scanner op",{"id":211,"funder":7,"programme":8,"title":212,"piName":10,"institution":213,"country":107,"year":13,"amount":14,"abstract":214},"cordis-european-research-council-award-963910","Selective Inhibition of NOTCH by novel γ-Secretase Inhibitors in Tumours","UNIVERSITEIT MAASTRICHT","Cancer remains one of the deadliest diseases and most deaths are due to treatment failure and metastasis. Tumor resistance and patient outcome are strongly associated with tumor heterogeneity, which is promoted by the self-renewing and multipotent cancer stem cells (CSC) and by limitations in oxygen availability generating hypoxic areas within the tumor microenvironment. The NOTCH signaling pathway is one CSC pathways frequently deregulated in human cancers but also essential in many normal tiss",{"id":216,"funder":7,"programme":8,"title":217,"piName":10,"institution":218,"country":69,"year":13,"amount":14,"abstract":219},"cordis-european-research-council-award-964009","Artificial Intelligence for Lyrics Comprehension","IE UNIVERSIDAD","The age of machine learning and data analytics have changed the habits of entertainment. Recommendation systems have been improving in the last years, with relevant commercial purposes, and many top-level companies –such as Amazon, Google or Netflix- are investing high amounts of money in improving their algorithms based on Artificial Intelligence. The case of music has been especially relevant, as the market has drastically changed in the last 10 years, moving towards a user-centric streaming m",{"id":221,"funder":7,"programme":8,"title":222,"piName":10,"institution":223,"country":39,"year":13,"amount":14,"abstract":224},"cordis-european-research-council-award-966759","Flexible x-ray detectors for large area imagers: towards consumer electronics","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","Techniques for non-destructive and non-invasive inspections are more and more required in our society, in different areas such as medical, industrial and security. X-ray radiation and its detection is the current inspection tool, coupled with electronic systems to gather information. However, while the electronic has gone through an impressive development to respond more and more to the need of a capillary presence in our life, without disturbing perception, the X-ray detection has remained behi",{"id":226,"funder":7,"programme":8,"title":227,"piName":10,"institution":228,"country":118,"year":13,"amount":14,"abstract":229},"cordis-european-research-council-award-966710","A new spectrophotometer for measurements in turbid liquids","LUNDS UNIVERSITET","The ability to analyse compounds within turbid\u002Fscattering liquids is very important in fields related to Environmental monitoring, Medical analysis, Pharmaceutical testing and Food processing. However, for turbid liquids that include dirty water, blood, milk as well as unfiltered beer, wine, oils etc, unwanted multiple scattering effects occur, preventing any measurement or introducing large errors. Thus, current commercially available spectrophotometers are not capable of measuring within such ",{"id":231,"funder":7,"programme":8,"title":232,"piName":10,"institution":233,"country":181,"year":13,"amount":14,"abstract":234},"cordis-european-research-council-award-966837","Laser remote sensing for monitoring air pollution over cities","ETHNIKO ASTEROSKOPEIO ATHINON","Poor air quality in cities around the world is a major societal and economic issue, causing more than 5.5 million premature deaths and resulting in €4.3 trillion in welfare losses. Preserving and improving the public health requires effective monitoring of air pollutants from their sources to their transport within the city web, however existing air quality monitoring networks have either very low spatial resolution or low accuracy to serve this purpose. Building on the technology solutions deve",{"id":236,"funder":7,"programme":8,"title":237,"piName":10,"institution":238,"country":45,"year":13,"amount":14,"abstract":239},"cordis-european-research-council-award-963903","SoftReVision - SOftware for the REhabilitation of Vision","HEINRICH-HEINE-UNIVERSITAET DUESSELDORF","Stroke is the third leading cause of death in Europe. In 2015, 613.148 people died of stroke, producing suffering in the patients and an economic burden of 45 billion euros. Most suffering and thereby the economic burden could be reduced if rehabilitation would be early and intense enough, thus resulting in an autonomous mobility in patients. Current rehabilitation procedures for post-stroke symptoms do not lead to quick and long-term recovery. With SoftRevision, a rehabilitation software shall ",{"id":241,"funder":7,"programme":8,"title":242,"piName":10,"institution":117,"country":118,"year":13,"amount":14,"abstract":243},"cordis-european-research-council-award-966636","Hybrid drug-loaded plasmonic photothermal microneedle patch against skin infections","In this proof of concept project, we will assess the technical and commercial feasibility of a hybrid microneedle patch for the treatment of nosocomial skin infections caused by drug resistant bacteria. Not only does this device permeate difficult-to-penetrate skin layers to deliver antibiotics locally, it also weakens bacterial defences by raising local temperature to enhance drug effectiveness. In this manner, the need for high dosage systemic drug administration is avoided – reducing occurren",{"id":245,"funder":7,"programme":8,"title":246,"piName":10,"institution":247,"country":28,"year":13,"amount":14,"abstract":248},"cordis-european-research-council-award-963976","Commercial assessment of a novel protocol for epilepsy characterisation with temporally interfering electric fields","UNIVERSITE D'AIX MARSEILLE","The ERC StG project “Epilepsy Controlled with Electronic Neurotransmitter Delivery (EPI-Centrd)” is focused on improved therapeutic intervention in drug-resistant patients with surgically-complicated forms of epilepsy. These patients represent a large demographic needing new commercial solutions, as there are fifty million people in the world with epilepsy and up to 50 cases of new-onset epilepsy per 100,000 people each year, where 30% of these cases are patients with drug-resistant epilepsy. Al",{"id":250,"funder":7,"programme":8,"title":251,"piName":10,"institution":203,"country":12,"year":13,"amount":14,"abstract":252},"cordis-european-research-council-award-899538","Bench-top system for detection and analysis of miRNA using solid-state nanopores","The fast and reliable detection of single molecules holds the promise of revolutionising diagnostics, disease prevention as well as biological research by offering unprecedented resolution compared to bulk approaches. Based on work done as part of the ‘DesignerPore’ ERC consolidator grant (Nature Nanotechnology 2016) we will develop a benchtop device capable of detecting hundreds of molecular targets within tens of minutes. We will combine our recent development in nanopore sensing technology (J",{"id":254,"funder":7,"programme":8,"title":255,"piName":10,"institution":256,"country":45,"year":13,"amount":14,"abstract":257},"cordis-european-research-council-award-963923","Fast Response Circuits for Voltage Droop Compensation","CISPA - HELMHOLTZ-ZENTRUM FUR INFORMATIONSSICHERHEIT GGMBH","Voltage droops are unpredicted drops in the supply voltage of computer chips, which often occur as a result of nearby bursts of high intensity circuit activity. This proposal is concerned with fast voltage droops, where voltage drops within a few clock cycles. This means that any dynamic response must take place within one or at most two clock cycles. A promising direction for combining the advantages of a stable reference clock with a small response time are mixed-signal control loops, in which",{"id":259,"funder":7,"programme":8,"title":260,"piName":10,"institution":261,"country":262,"year":13,"amount":14,"abstract":263},"cordis-european-research-council-award-966824","Wafer-scale, fully automated solid-state nanopore fabrication for biomolecular sensing","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","IL","Solid-state nanopores (ssNPs) are an emerging class of single-molecule devices, which have proven useful in a broad range of applications, from sensing COVID-19 RNAs to proteins biomarkers. To date, ssNP fabrication costs, throughput and instrumentation have remained the bottlenecks towards broad adoption of ssNP sensing in biomedical research labs and in industry. To address this need, we will apply our optical method for the creation of nanoscale apertures in thin films. OptiPore aims are to d",{"id":265,"funder":7,"programme":8,"title":266,"piName":10,"institution":267,"country":12,"year":13,"amount":14,"abstract":268},"cordis-european-research-council-award-956151","Pure, separated hydrogen from shift processes","UNIVERSITY OF NEWCASTLE UPON TYNE","PuSH – Pure, separated hydrogen from shift processesHere, I plan to exploit recent innovations made in my ERC Advanced Grant, SPeED, on the cyclic operation (or chemical looping) of chemical reactors to deliver transformational processes for chemical conversions relevant to the energy sector.  We have recently shown (Nature Chemistry, 11, pages 638–643 (2019), video at http:\u002F\u002Fnuvision.ncl.ac.uk\u002FPlay\u002F18143) that a chemical looping reactor can produce pure, separated streams of carbon dioxide and ",{"id":270,"funder":7,"programme":8,"title":271,"piName":10,"institution":272,"country":69,"year":13,"amount":14,"abstract":273},"cordis-european-research-council-award-963443","Commercial feasibility of targeting the histone methyltransferase SETD8 in cancer: New chemical entities and biomarkers.","FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III","Within our ERC CoG grant, RSHEALTH, our group has contributed to the to the preclinical development of chemical inhibitors of the ATR kinase as anticancer agents, that are now in clinical trials by several companies. During the course of our investigations, we also made important advances in developing inhibitors of SETD8, another interesting cancer-related target. SETD8 is a histone methyltransferase known to play important roles in DNA replication and repair. Evidence indicating that targeting",{"id":275,"funder":7,"programme":8,"title":276,"piName":10,"institution":277,"country":107,"year":13,"amount":14,"abstract":278},"cordis-european-research-council-award-963950","Breath analysis sensor for disease detection in the dairy industry","STICHTING VU","Dairy products accounts for some 5% of the global food intake, with dairy industry revenues in 2019 of around €675 billion. This dietary component is important in the global challenge of feeding the increasing human population that is expected to reach 9.7 billion in 2050. To attain peak productivity and efficiency, the health and well-being of each dairy cow is of paramount importance. We aim to use a non-invasive and automated spectroscopic sensor applied on breath, so that illness in individu",{"id":280,"funder":7,"programme":8,"title":281,"piName":10,"institution":282,"country":283,"year":13,"amount":14,"abstract":284},"cordis-european-research-council-award-957444","Proof of Concept study for the development of methylation based NIPT for trisomy 21 using droplet digital PCR","NIPD GENETICS PUBLIC COMPANY LIMITED","CY","Scientific and medical evidence indicate that non-invasive prenatal testing (NIPT) offers to pregnant women a safe optionduring their pregnancy as it provides no risk of miscarriage. The NIPT is based on a genetic examination of plasma collectedfrom a pregnant woman. The discovery of cell-free fetal DNA (cff DNA) in maternal plasma during pregnancy provides apromising source of fetal genetic material for the development of reliable methods for NIPT. In the last years, NIPT has beenwidely adopted",{"id":286,"funder":7,"programme":8,"title":287,"piName":10,"institution":288,"country":107,"year":13,"amount":14,"abstract":289},"cordis-european-research-council-award-957641","Inventive Neurophysiology Software, Outputting Measures of Nocturnal Instability Automatically in Anxiety, Insomnia & Depression","KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW","A recent surge in consumer products to record sleep and provide feedback on its duration show that a large market exists for sleep improvement. Ensuring high quality sleep is at least as important to promote health as exercise, restricting caloric intake and quitting smoking and alcohol. Consumers are keen to utilize tools that help them attain these aims. Commercially available devices recording movement and physiology provide consumers with an estimate of SLEEP DURATION. However, novel finding",{"id":291,"funder":7,"programme":8,"title":292,"piName":10,"institution":293,"country":262,"year":13,"amount":14,"abstract":294},"cordis-european-research-council-award-966826","Engineering B cells against HIV using Switch targeting","TEL AVIV UNIVERSITY","Chronic antiretroviral therapy (ART) does not eradicate HIV infection. As a potentially single-shot alternative, B cells engineered by CRISPR\u002FCas9 to express anti-HIV broadly neutralizing antibodies (bNAbs) were shown capable of secreting high and neutralizing antibody titers. In particular, we previously demonstrated that, upon immunization of mice, adoptively transferred B cells, that were engineered at the immunoglobulin heavy (IgH) locus by CRISPR\u002FCas9, differentiate into memory and plasma c",{"id":296,"funder":7,"programme":8,"title":297,"piName":10,"institution":223,"country":39,"year":13,"amount":14,"abstract":298},"cordis-european-research-council-award-966674","INtroDucing axial rEsolution in oPToelectronic implantable devices for tHe brain","IN DEPTH aims at developing the first brain implantable device able to gather simultaneously electrophysiology and optical signals with depth resolution and reduced invasiveness. Neuroscientists and neurosurgeons are indeed still limited in accessing and addressing deep brain structures, while the field would instead greatly benefit of low-invasiveness probes monitoring bio-electronic and optical signals with spatial resolution, for both neuroscience and neurosurgery applications.IN DEPTH will a",{"id":300,"funder":7,"programme":8,"title":301,"piName":10,"institution":191,"country":192,"year":13,"amount":14,"abstract":302},"cordis-european-research-council-award-963884","AI-driven enhancer design for gene therapy","Gene therapy promises to become a durable clinical option for a whole range of diseases, including monogenic hereditary diseases, cancer and neurodegenerative disorders. However, the development of new gene therapy-based treatments strongly depends on regulatory drivers that provide cell-type specific expression of the transgene, at high enough levels, yet without causing genotoxicity.The aim of the ERC PoC proposal is to validate a state-of-the-art pipeline, called EnhancerDesign, to design sma",{"id":304,"funder":7,"programme":8,"title":305,"piName":10,"institution":306,"country":262,"year":13,"amount":14,"abstract":307},"cordis-european-research-council-award-963863","Single-Molecule Epigenetic Analysis of Plasma Isolated Nucleosomes for Colon Cancer Diagnostics","WEIZMANN INSTITUTE OF SCIENCE","The analysis of cell-free DNA (cfDNA) in plasma represents a rapidly advancing field in medicine, with developing methods aiming to utilize it for diagnostics of cancer and additional pathologies. Most liquid biopsy methods are sequencing-based and provide limited information, usually relying on the detection of rare cancer-associated mutations. Therefore, they are costly and highly limited in their sensitivity. Importantly, blood cfDNA consists predominantly in the form of nucleosomes, which ma",{"id":309,"funder":7,"programme":8,"title":310,"piName":10,"institution":311,"country":312,"year":13,"amount":14,"abstract":313},"cordis-european-research-council-award-966718","Dual-comb laser driven terahertz spectrometer for industrial sensing","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","CH","Optical absorption spectroscopy is a key enabling technology for contact-free and non-destructive identification of materials. Since these measurements allow for identifying defects or contaminants in products, they are used in many industries. Examples include testing of polymers, coatings and paints, pharmaceuticals, foods, and semiconductor devices for electronics. Optical spectroscopy also has emerging applications in environmental monitoring, security, and medical diagnostics. Light in the ",{"id":315,"funder":7,"programme":8,"title":316,"piName":10,"institution":317,"country":12,"year":13,"amount":14,"abstract":318},"cordis-european-research-council-award-963980","PrInted gRAphene ThermocouplE for the IoTs","THE UNIVERSITY OF MANCHESTER","Accurate real-time temperature measurement is very important in many applications. In particular,  contact-type temperature sensors for nano or microscope measurement of temperature are expected to strongly rise in the next future due to their use in wearables, smartphones, and other consumer electronics devices. However, the development of sensitive and localised temperature sensor is a strong technical challenge, in particular when coupled with flexible substrates, such as those used for packa",{"id":320,"funder":7,"programme":8,"title":321,"piName":10,"institution":322,"country":262,"year":13,"amount":14,"abstract":323},"cordis-european-research-council-award-966830","An embryo transfer decision-support tool optimizes live-birth rates in IVF treatments","THE HEBREW UNIVERSITY OF JERUSALEM","In vitro fertilization (IVF) treatments are markedly inefficient since a significant fraction of embryos lacks the capacity to implant. Even for successfully implanted embryos, one out of nine clinical pregnancies is terminated due to first trimester miscarriage. In general, embryos that harbor certain chromosomal abnormalities leading to early pregnancy loss often permit “normal preimplantation development” that cannot be detectable via human visualization of time lapse images. Since current st",{"id":325,"funder":7,"programme":8,"title":326,"piName":10,"institution":277,"country":107,"year":13,"amount":14,"abstract":327},"cordis-european-research-council-award-966625","Preventing unnecessary biopsies in the diagnosis pathway of cervical cancer.","The goal of the DIADEPH project is to develop a “Business Proposition Package” that could enable our group to eventually bring a new non-invasive gynaecological device to market. The device holds promise to reduce the number of biopsies that are currently carried out to rule out cervical cancer, thus mitigating the pain, anxiety, and financial costs that the shortcomings of the diagnosis pathway brings today on patients, their families, and our society.  Every year, more than half-a-million wome",{"id":329,"funder":7,"programme":8,"title":330,"piName":10,"institution":331,"country":39,"year":13,"amount":14,"abstract":332},"cordis-european-research-council-award-963982","Pharmacological restoration of selective autophagy for the treatment of skeletal disorders","FONDAZIONE TELETHON ETS","Lysosomal storage disorders (LSDs) are a family of inherited genetic diseases characterized by lysosomal dysfunction, with a consequent block in the degradative capacity of the cell. The skeleton is one of the most affected organs in LSD patients and current therapies are largely ineffective for the treatment of bone and cartilage manifestations.  Thanks to the support of the ERC-starting grant BONEPHAGY we demonstrated that the degradation of the endoplasmic reticulum fragments via lysosome\u002Faut",{"id":334,"funder":7,"programme":8,"title":335,"piName":10,"institution":336,"country":192,"year":13,"amount":14,"abstract":337},"cordis-european-research-council-award-966677","Forward Slice Core","UNIVERSITEIT GENT","There are two major flavors of processor core microarchitectures, namely the in-order core and the out-of-order core. Out-of-order processors deliver high performance while incurring high design complexity, large chip area and high power consumption. In-order processors on the other hand feature low complexity, small chip area and low power consumption, but deliver limited performance. There is a clear need for a novel core microarchitecture that delivers high performance at low hardware complex",{"id":339,"funder":7,"programme":8,"title":340,"piName":10,"institution":223,"country":39,"year":13,"amount":14,"abstract":341},"cordis-european-research-council-award-899963","An easy-to-use garment for the non-invasive recording of the electrical activity of the human spinal cord","Lesions of the spinal cord in humans are devastating and often lead to severe refractory forms of chronic pain. Also, enhanced sensitivity of spinal cord neurons – an abnormal condition called central sensitization – is crucial for the development and maintenance of chronic pain. Effective treatment of pain will depend critically on a better understanding of the electrophysiological changes that occur at spinal cord level. Still, the electrical activity of spinal cord neurons can be assessed onl",{"id":343,"funder":7,"programme":8,"title":344,"piName":10,"institution":345,"country":346,"year":13,"amount":14,"abstract":347},"cordis-european-research-council-award-966846","Supersonic material ablation at THz repetition rates for ultra-efficient laser micromachining","BILKENT UNIVERSITESI VAKIF","TR","We have recently demonstrated a new laser-material processing regime, known as the ablation-cooled laser-material removal, which proved to be 10 times more efficient using 100 thousand times lower pulse energies than traditional ultrafast processing. We have recently demonstrated a new laser-material processing regime, known as the ablation-cooled laser-material removal, which proved to be 10 times more efficient using 100 thousand times lower pulse energies than traditional ultrafast processing",{"id":349,"funder":7,"programme":8,"title":350,"piName":10,"institution":96,"country":39,"year":13,"amount":14,"abstract":351},"cordis-european-research-council-award-966725","effIcieNt Small scale uniT for distributed heAt and hydrogeN generaTion","The project task is the development and validation of an efficient catalytic fuel processor as the key component of smallscale units for combined heat and power (CHP) generation in residential applications, based on hydrogen-fuel cells and fed bynatural gas, air and water. A critical issue of these devices is the intensification of the heat supply in the compact methane steam reformerwhere hydrogen is generated. To this purpose we exploit the findings from my ERC AdG project INTENT, developing a",{"id":353,"funder":7,"programme":8,"title":354,"piName":10,"institution":355,"country":12,"year":13,"amount":14,"abstract":356},"cordis-european-research-council-award-966782","RNA NanopartIcles for Cardiac rEgeneration","KING'S COLLEGE LONDON","Prompt coronary catheterization and revascularization have dramatically improved the outcome of myocardial infarction, but also have resulted in a growing number of survived patients with permanent damage of the heart, which frequently leads to heart failure. This condition is now common, expensive and lethal. All currently available drugs for heart failure are aimed at improving residual cardiac performance, while none counteracts the loss of cardiomyocytes. We aim at developing an innovative b",{"id":358,"funder":7,"programme":8,"title":359,"piName":10,"institution":360,"country":361,"year":13,"amount":14,"abstract":362},"cordis-european-research-council-award-956900","Riding a ‘Trojan horse’ against cancer","SZKOLA GLOWNA GOSPODARSTWA WIEJSKIEGO","PL","New therapeutic approaches have led to significant improvements in cancer treatment, but none have been able to overcome the limited efficacy of solid tumor treatment due to poor tumor delivery and the presence of hypoxic tumor cells. Macrophages represent a promising vesicle to deliver cancer therapeutics to solid tumors as they are continuously recruited into the tumor mass, even the most hypoxic regions. Our pioneering research demonstrated that macrophages are able to take up ferritins loade",{"id":364,"funder":7,"programme":8,"title":365,"piName":10,"institution":366,"country":39,"year":13,"amount":14,"abstract":367},"cordis-european-research-council-award-966334","Lead-free halide perovskites for the highest efficient solar energy conversion","UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II","Halide perovskites are the next big thing in solar energy. State-of-the-art perovskite solar cells outperform established technologies with the advantage of processing from solution. Solution-processed perovskite solar cells are made spraying a precursor ink onto a substrate: the perovskite forms as the chemicals contained in the ink crystallize. This production process makes halide perovskites a valid low-cost alternative established material such as silicon. Furthermore, halide perovskite can ",{"id":369,"funder":7,"programme":8,"title":370,"piName":10,"institution":371,"country":69,"year":13,"amount":14,"abstract":372},"cordis-european-research-council-award-957581","A Human Neural Platform for Assaying Antigen-Antibody Interactions for Autoimmune Encephalitis","FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE","Autoimmune encephalitides (AE) are a category of diseases that result from an immune attack against proteins present in patient’s own brain cells (antigens). Clinical symptoms include both neurological and psychiatric manifestations, that differ greatly between patients and during disease progression. Upon prompt diagnosis and immunotherapy symptoms gradually resolve. Current epidemiological studies estimate an annual incidence of encephalitis of any aetiology is 2-3 patients per 100.000 per yea",{"id":374,"funder":7,"programme":8,"title":375,"piName":10,"institution":191,"country":192,"year":13,"amount":14,"abstract":376},"cordis-european-research-council-award-959109","Generating superior industrial yeasts through modulation of Crabtree repression","The common baker's yeast, Saccharomyces cerevisiae, is used in various industrial applications, ranging from the production of fermented beverages like beer and wine, foods including bread and chocolate, bioethanol, enzymes and pharmaceuticals. S. cerevisiae cells can grow aerobically, using the TCA cycle and electron transport chain to produce around 16 to 18 molecules of ATP (energy) per glucose molecule. However, when glucose concentrations exceed about 1% (w\u002Fw), the cells tend to shut down t",{"id":378,"funder":7,"programme":8,"title":379,"piName":10,"institution":380,"country":139,"year":13,"amount":14,"abstract":381},"cordis-european-research-council-award-862344","A novel medical device for the treatment of Endometriosis","UNIVERSITY OF GALWAY","Endometriosis is one of the most prevalent, impactful and undertreated disorders to affect European women. The condition is defined as an estrogen-dependent disorder, where endometrial tissue forms lesions outside the uterus resulting in chronic pain and infertility. Endometriosis affects an estimated 10% of European women in the reproductive-age group (176 million women worldwide and 10.7 million in the EU) with significant impact on their physical, mental, and social well-being (This impact is",{"id":383,"funder":7,"programme":8,"title":384,"piName":10,"institution":203,"country":12,"year":13,"amount":14,"abstract":385},"cordis-european-research-council-award-966581","Solar-driven reforming of waste into hydrogen","Waste disposal leads to environmental pollution, greenhouse gas emissions, and a loss of chemical and energy-rich resources. Photoreforming is a sunlight-driven technology that recaptures the value in waste while simultaneously contributing to renewable energy production by transforming biomass, food and plastic waste into hydrogen. However, our current photoreforming process relies on corrosive acids or bases in order to solubilise waste and enhance hydrogen generation, which raises sustainabil",{"id":387,"funder":7,"programme":8,"title":388,"piName":10,"institution":389,"country":390,"year":13,"amount":14,"abstract":391},"cordis-european-research-council-award-966721","The Picture Pile Platform","INTERNATIONALES INSTITUT FUER ANGEWANDTE SYSTEMANALYSE","AT","There has been tremendous progress in artificial intelligence (AI) in many different fields due to improved machine learning algorithms, advances in computing power and the availability of big data. With machine learning platforms like TensorFlow (Google), PyTorch (Facebook), Azure (Microsoft) or CoreML (Apple), researchers and application developers can now use AI for applications such as computer vision. While there are many image databases available such as Imagenet, which can be used to trai",{"id":393,"funder":7,"programme":8,"title":394,"piName":10,"institution":395,"country":45,"year":13,"amount":14,"abstract":396},"cordis-european-research-council-award-963941","Acquiring assembly skills by robot learning","TECHNISCHE UNIVERSITAT DARMSTADT","Present-day industrial robots are made for the purpose of repeating several tasks thousands of times. What themanufacturing industry needs instead is a robot that can do thousands of tasks, a few times. Programming a robot to solvejust one complex motor task has remained a challenging, costly and time-consuming task. In fact, it has become the keybottleneck in industrial robotics. Empowering robots with the ability to autonomously learn such tasks is a promisingapproach, and, in theory, machine ",{"id":398,"funder":7,"programme":8,"title":399,"piName":10,"institution":400,"country":401,"year":13,"amount":14,"abstract":402},"cordis-european-research-council-award-966781","A novel chemical discovery platform enabled by machine learning","UNIVERSITE DU LUXEMBOURG","LU","Computational design and discovery of molecules and materials relies on the exploration of increasingly growing chemical spaces. The discovery and formulation of new drugs, antivirals, antibiotics, catalysts, battery materials, and in general chemicals with tailored properties, require a fundamental paradigm shift to search in unchartered swaths of the vast chemical space. This is in stark contrast to current approaches, which start from (commercially available) libraries of compounds from vario",{"id":404,"funder":7,"programme":8,"title":405,"piName":10,"institution":406,"country":312,"year":13,"amount":14,"abstract":407},"cordis-european-research-council-award-957508","Finding and Assessing proteIn nano-crystaLs, a Fail fAst STory","ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE","High-resolution protein structures obtained by X-ray diffraction require the production of well-ordered proteins crystals of high quality. However, to produce well-ordered protein crystals, several bottlenecks must be addressed to screen and optimize the thousands of conditions that can lead to crystallization. In this project, we will accelerate the process of protein crystallization by detecting early, i.e., assessing nano-crystal formation and providing immediate feedback, instead of waiting ",{"id":409,"funder":7,"programme":8,"title":410,"piName":10,"institution":411,"country":45,"year":13,"amount":14,"abstract":412},"cordis-european-research-council-award-966770","Power in Low Earth Orbit. Verified.","UNIVERSITAT DES SAARLANDES","More than 17,000 satellites are announced for launch into Low Earth Orbit (LEO) before 2027, for the purpose of real-time Earth observation and worldwide connectivity. The multitude of mission initiatives is a sign of democratization of space and induces enormous business opportunities. LEOpowver will harvest results of the ERC Advanced Grant POWVER for the LEO market to arrive at orbit-proof software for the continuous, fully automated, power-optimal and profit maximising dynamic operation of L",{"id":414,"funder":7,"programme":8,"title":415,"piName":10,"institution":416,"country":45,"year":13,"amount":14,"abstract":417},"cordis-european-research-council-award-966709","Inducible Human Photoreceptors for Research, Development and Therapy to Prevent Blindness","UNIVERSITATSKLINIKUM BONN","One of the major causes of adult visual impairment and blindness in industrialized countries is the progressive dysfunction and death of photoreceptor cells (PR) as a result of retinal degenerative diseases. Current treatment options are still insufficient to counteract these forms of blindness. The development of many drugs and therapies fail in preclinical stages because the used animal models are suboptimal for translating results from the bench to the bedside. Especially, for testing the tra",{"id":419,"funder":7,"programme":8,"title":420,"piName":10,"institution":421,"country":422,"year":13,"amount":14,"abstract":423},"cordis-european-research-council-award-966685","Integrated Solar Energy System","UNIVERSIDADE NOVA DE LISBOA","PT","The INSOLENSYS technology is proposing a game-changing concept for solar energy management.It introduces, for the first time ever, an integrated approach to the generation and storage within PV cells which compensates the main drawback of current approaches, i.e. the need to manage the intermittency of solar energy through costly and polluting external storage systems.INSOLENSYS will deliver a flexible solution that can be adapted to all the types of solar cells, be it home system or large-scale",{"id":425,"funder":7,"programme":8,"title":426,"piName":10,"institution":406,"country":312,"year":13,"amount":14,"abstract":427},"cordis-european-research-council-award-963913","Construction & Environmental Biocementation in REal World Applications","CEBREWA (Construction & Environmental Biocementation in REal World Applications) tackles the emerging ground stabilisation problems which are becoming increasingly pressing in construction and environmental engineering. Ground stabilization mitigates stability risks associated with geohazards, such as earthquakes, soil erosion, and landslides. Such problems are expected to be further intensified by extreme weather and aging infrastructure. Traditionally, ground stabilization is applied to roads,",{"id":429,"funder":7,"programme":8,"title":430,"piName":10,"institution":406,"country":312,"year":13,"amount":14,"abstract":431},"cordis-european-research-council-award-966786","On-chip efficient storage of electrical energy with negative super-capacitance in 2D material systems","We propose the combination of two performance boosters: (i) negative capacitance principle, exploiting  ferroelectricity in doped high-k dielectrics, as developed and validated in 2D devices of our ERC Advanced grant Millitech, and, (ii) 2D graphene electrodes to enhance the performance of supercapacitors in on-chip 2D material systems, in an innovative device called N-supercap. While negative capacitance was until now explored mainly for digital and analog low power electronics, we propose to e",{"id":433,"funder":7,"programme":8,"title":434,"piName":10,"institution":435,"country":12,"year":13,"amount":14,"abstract":436},"cordis-european-research-council-award-966740","Protein Nanosheet-Stabilised Emulsions for Next Generation Biomanufacturing","QUEEN MARY UNIVERSITY OF LONDON","The large scale expansion of adherent cells, which underpins the production of stem cells for regenerative medicine and the manufacturing of complex biotherapeutics (e.g. exosomes and vaccines) remains challenging and a key hurdle to the accessibility of associated therapies. Indeed, the expansion of adherent stem cells and adherent cell lines for bioproduction relies on culture on solid microcarriers that remain difficult to process and significantly add to costs. Cell adhesion to solid substra",{"id":438,"funder":7,"programme":8,"title":439,"piName":10,"institution":440,"country":441,"year":13,"amount":14,"abstract":442},"cordis-european-research-council-award-966654","Assessing the Technical and Business Feasibility of Highly-active and Stable Intermetallic Pt-alloy Catalysts for Application in PEMFCs","KEMIJSKI INSTITUT","SI","Proton exchange membrane fuel cells (PEMFC) are crucial in the race towards cutting the greenhouse gas emissions – covering 90.7% of total fuel cell market share already in 2018. PEMFCs as a zero-carbon technology converts hydrogen, as a fuel, and oxygen from the air into clean electricity, with water being the only by-product. In doing so, the catalyst material plays a crucial role. Currently, the most promising strategy is to use scarce and expensive platinum (Pt) in the form of carbon-support",{"id":444,"funder":7,"programme":8,"title":445,"piName":10,"institution":446,"country":39,"year":13,"amount":14,"abstract":447},"cordis-european-research-council-award-957563","Fighting cancer relapse with remote activation of smart and targeted nanoconstructs","POLITECNICO DI TORINO","This project XtraUS focuses on the prevention of cancer relapse and on the achievement of an early cure of recurrence, thus having a heavy  impact on health and on its financial implications. Actually, many patients unfortunately get into a recurrence of their primary tumor disease, since their cancer is not fully remitted and they require further treatment to manage it. Minimal residual disease (MRD) after potentially curative treatment generally contributes to disease relapse and is the target",{"id":449,"funder":7,"programme":8,"title":450,"piName":10,"institution":451,"country":12,"year":13,"amount":14,"abstract":452},"cordis-european-research-council-award-966855","A sweet solution: novel antiviral siRNAs to help rescue the sugar beet industry","JOHN INNES CENTRE","Beet Yellows Virus (BYV) is one of the most destructive pathogens, causing Virus Yellows disease that underlies up to 50% yield losses in sugar beet. The recent regulatory ban on the use of neonicotinoid pesticides in EU has worsened the damage to the EU sugar beet industry. Given the urgency of the current problem caused by BYV, we propose to take advantage of a molecular biological approach to employ small molecular inhibitors called “artificial small interfering RNAs” (art-siRNAs), and demons",{"id":454,"funder":7,"programme":8,"title":455,"piName":10,"institution":456,"country":12,"year":13,"amount":14,"abstract":457},"cordis-european-research-council-award-966774","Smell Healthcare Technology to Enable Digital Smell Training","OWIDGETS LTD","The aim of this ERC PoC is to enable the design of new digital smell healthcare applications (e.g. smell training) through the development of a highly accurate, efficient, adaptive, and affordable smell-delivery technology (hardware and software components), and demonstrate its use to healthcare professionals. The human sense of smell is powerful, it makes an important and yet often undervalued contribution to our life and wellbeing with a unique link to emotions and memories. Smell dysfunctions",{"id":459,"funder":7,"programme":8,"title":460,"piName":10,"institution":461,"country":107,"year":13,"amount":14,"abstract":462},"cordis-european-research-council-award-966785","Communicate Heal-th: A Virtual Reality training tool for optimizing expectancy effects in patient-provider interaction","UNIVERSITEIT LEIDEN","As shown in the EXPECT-HEALTH project (617700), positive treatment expectations lead to improved health outcomes, while negative expectations have the opposite effect. To make use of this phenomenon in clinical practice, interventions have been developed to improve treatment expectations in patients, but these thus far only target the patient. A novel application would be to instead train healthcare professionals to optimize the expectations of their patients. This allows a much bigger audience ",{"id":464,"funder":7,"programme":8,"title":465,"piName":10,"institution":466,"country":39,"year":13,"amount":14,"abstract":467},"cordis-european-research-council-award-875139","Pharmacological inhibition of macrophage activation","IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS","Macrophages are innate immune cells that specialise in sensing and responding to the presence of pathogens and they have been causally involved in the pathogenesis of both sepsis and rheumatoid arthritis (RA). Both diseases represent a high cost to the economy and society of European countries characterized by an aging population as well as developing countries. Sepsis is the first cause of death in hospitalized patient, with an estimate of 5 million deaths each year. Currently, there are no eff",{"id":469,"funder":7,"programme":8,"title":470,"piName":10,"institution":79,"country":69,"year":13,"amount":14,"abstract":471},"cordis-european-research-council-award-966743","A New Zn-Air Battery Prototype to Overcome Cathode Degradation Through Catalyst Confinement","Zinc-air rechargeable batteries are a promising alternative for sustainable energy storage, thanks to their high energy density and the use of abundant materials with low environmental impact, as well as their safe operation. However, they still have some technological limitations that prevent their current capacity from being completely satisfactory, especially because of the degradation that occurs at the cathode and corrosion of the anode, which ultimately limit both the reversibility and a l",{"id":473,"funder":7,"programme":8,"title":474,"piName":10,"institution":475,"country":45,"year":13,"amount":14,"abstract":476},"cordis-european-research-council-award-966791","Entropic rejuvenation of thin glass products by liquid metal immersion","FRIEDRICH-SCHILLER-UNIVERSITÄT JENA","Mechanical performance and consumer product safety have been major drivers for glass research and innovation. Strengthened glass products are omnipresent in daily life, from rooftop windows and automotive windshields to solar modules, partition walls and covers for handheld electronic devices. However, thermal strengthening as today’s most widespread method for enhancing the strength and reliability of glasses has reached maturity, leaving fundamental restrictions in terms of applicable glass th",{"id":478,"funder":7,"programme":8,"title":479,"piName":10,"institution":480,"country":346,"year":13,"amount":14,"abstract":481},"cordis-european-research-council-award-966765","Fully implantable patient-specific Artificial Hearts without External Power","KOC UNIVERSITY","Patient population with end-stage heart failure in the EU grows by 5M annually. Due to donor shortage, only a handful of patients ever receive cardiac transplantation. Unfortunately, this results in 250K deaths every year. Long-term mechanical circulatory support (MCS) is a solution, but external power needs result in driveline infections and bulky systems limiting patient mobility. An innovative blood turbine device emerged from the parent ERC that can overcome these limitations. This novel tur",{"id":483,"funder":7,"programme":8,"title":484,"piName":10,"institution":485,"country":107,"year":13,"amount":14,"abstract":486},"cordis-european-research-council-award-963876","Improving the safety of live attenuated viral vaccines by exploiting RNA silencing pathways","STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM","Live-attenuated viral vaccines are among the most successful vaccine approaches and have been used for decades. However, live-attenuated vaccines come with a risk of reversion or recombination of the vaccine to a virulent form. An important consideration for live-attenuated vaccines for arthropod-borne (arbo-) viruses is that they should not replicate in their mosquito vectors to prevent unwanted spread of the vaccine and vaccine-derived virulent strains. In this ERC Proof-of-Concept project (VI",{"id":488,"funder":7,"programme":8,"title":489,"piName":10,"institution":389,"country":390,"year":13,"amount":14,"abstract":490},"cordis-european-research-council-award-957509","Fair Pensions and Population Ageing","Demographic changes in survival rates and age structures require adaptions in public policies. This grant will produce a social benefit by providing policy makers with two kinds of tools that they will need to make these adaptions, fair normal pension ages and consistently up-to-date measures of population ageing that take the changing characteristics of populations into account. An important area of adaption is national pension policy. Recently changes in pension policies have been driven by fi",{"id":492,"funder":7,"programme":8,"title":493,"piName":10,"institution":494,"country":107,"year":13,"amount":14,"abstract":495},"cordis-european-research-council-award-966753","Intraveneously injected unusual nanoparticles in the clinic","CENYA IMAGING B.V.","Cancer. Cardiovascular disease. Autoimmune disease. Neurological disease. Rheumatoid arthritis. What do these diseases have in common? -Chronic inflammation.In recognition of this, the NIH organised a focus session on the current clinical needs around inflammation in 2019, stating “Tools to locate and monitor inflammation are critical for developing effective interventions to arrest inflammation and promote its resolution. Clinical speakers described their needs for image‐based capabilities ... ",{"id":497,"funder":7,"programme":8,"title":498,"piName":10,"institution":499,"country":12,"year":13,"amount":14,"abstract":500},"cordis-european-research-council-award-957535","Disruptive fluorescent technologies for inflammatory bowel diseases","THE UNIVERSITY OF EDINBURGH","Inflammatory bowel diseases (IBD) are chronic immune-mediated disorders causing inflammation of the gastrointestinal tract, which affect around 3 million patients in the EU. Current monitoring of IBD is mainly performed in the form of colonoscopies, biopsies or tests which are invasive or cannot specifically report on IBD activity. There is a need for new technologies that can rapidly measure activity biomarkers of IBD and enable the monitoring of disease progression and response to therapy accu",{"id":502,"funder":7,"programme":8,"title":503,"piName":10,"institution":504,"country":107,"year":13,"amount":14,"abstract":505},"cordis-european-research-council-award-966703","Robust Actuation through Magnetism for Safe Endovascular Surgery","UNIVERSITEIT TWENTE","Endovascular interventions are an established class of procedures within minimally invasive surgery (MIS). They enable the treatment of cardiovascular diseases through small incisions in the body by using flexible instruments. Conventionally, these instruments are manually operated, which restricts their precision, and limits their applicability. The magnetic actuation of instruments for endovascular interventions creates a novel and effective steering alternative. Even in deeply seated regions,",{"id":507,"funder":7,"programme":8,"title":508,"piName":10,"institution":395,"country":45,"year":13,"amount":14,"abstract":509},"cordis-european-research-council-award-957521","Machine learning based Software Toolkit for Automated identification in atomic-REsolution operando nanoscopy","In recent years, the analysis of large data sets is becoming increasingly important in the fields of material science and engineering. There is a strong demand for real-time automated identification algorithms in electron microscopy (EM) for the analysis of atomic-structure, phases, and defects. Unfortunately, it is non-trivial to obtain or extract meaningful scientific information from raw EM output digital data. It requires a tedious process of filtering\u002Ffitting and the expertise of a seasoned",{"id":511,"funder":7,"programme":8,"title":512,"piName":10,"institution":513,"country":39,"year":13,"amount":14,"abstract":514},"cordis-european-research-council-award-963865","Discovery of mevalonate and UBIAD1 inhibitors as novel drugs targeting melanoma skin cancer","UNIVERSITA DEGLI STUDI DI PADOVA","Melanoma is the most aggressive skin tumor, extremely difficult to treat and with high mortality rate. Overcoming reduced sensitivity and acquired resistance to targeted therapy is a major goal of current melanoma research. Therefore, there is an urgent need for development of novel drugs that can cure and prolong the survival of melanoma patients. Molecular targeted therapy by using a drug that reduces the growth and spread of cancer cells via inhibition of specific protein or pathway is a mile",{"id":516,"funder":7,"programme":8,"title":517,"piName":10,"institution":518,"country":45,"year":13,"amount":14,"abstract":519},"cordis-european-research-council-award-963675","Bioprinting Complex Tissue-mimicking Architectures","DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV","Over the past ten years, 3D bioprinting has emerged as a powerful tool to fabricate human tissue models ex vivo. These models can be used for drug discovery, to obtain a better understanding of physiological and pathological mechanisms, and in the future to replace diseased or injured tissues and organs. To successfully fabricate functional tissues, 3D bioprinted constructs should emulate the anatomical features of the native tissue’s extracellular matrix (ECM). However, current bioprinting tech",{"id":521,"funder":7,"programme":8,"title":522,"piName":10,"institution":293,"country":262,"year":13,"amount":14,"abstract":523},"cordis-european-research-council-award-966813","Novel piezoelectirc peptide-based scaffold for 3D cell culture","Tissue regeneration has emerged as a promising novel therapy for various disease conditions. A key requirement for the implementation of this advanced approach is the efficient, reliable and reproducible growth of 3D cell cultures, including organoid structures. State-of-the-art 3D culture media support the growth of such cultures, yet exhibit several key setbacks, including low reproducibility and limited modularity. Moreover, no commercial piezoelectric media are currently available, thus proh",{"id":525,"funder":7,"programme":8,"title":526,"piName":10,"institution":311,"country":312,"year":13,"amount":14,"abstract":527},"cordis-european-research-council-award-964013","A Modular Earth System Model Emulator for Regional eXtremes","Climate extremes count among the most impactful consequences of climate change, also under low-emissions scenarios consistent with the aims of the Paris agreement. However, they are not factored in the derivation of emissions scenarios informing international policy options in reports from the Intergovernmental Panel on Climate Change (IPCC). Indeed, the Integrated Assessment Models (IAMs) underlying the development of these emissions scenarios only consider changes in mean climate when evaluati",{"id":529,"funder":7,"programme":8,"title":530,"piName":10,"institution":203,"country":12,"year":13,"amount":14,"abstract":531},"cordis-european-research-council-award-957356","Enabling Multilingual Conversational AI","In recent past, Conversational Artificial Intelligence (AI) has made major advances, thanks to the availability of big data and increasingly powerful deep learning. Task-based statistical dialogue systems (SDS) are now viable, embedded in popular commercial applications (e.g. the Apple’s Siri, Amazon’s Echo, Google’s Assistant) and cost-effective in many scenarios (e.g., customer support, call centre service, searching, booking). Yet current SDSs are only available for a handful of resource-rich",{"id":533,"funder":7,"programme":8,"title":534,"piName":10,"institution":336,"country":192,"year":13,"amount":14,"abstract":535},"cordis-european-research-council-award-966656","Exploring the market potential of photoporation as the next generation of intracellular delivery technology for the R&D and cell therapy markets","Delivering macromolecular compounds into living cells in vitro or ex vivo is a common requirement for both fundamental biological research as well as biomedical applications. Examples include the intracellular delivery of gene editing molecules to unravel molecular pathways or to create engineered therapeutic cells. Irrespective of the application, the common challenge is to combine efficient intracellular delivery with flexibility, high throughput and low cytotoxicity. Photoporation, which comb",{"id":537,"funder":7,"programme":8,"title":538,"piName":10,"institution":539,"country":45,"year":13,"amount":14,"abstract":540},"cordis-european-research-council-award-966687","Novel small molecule activators of the NLRP3 inflammasome as immunostimulants","UNIVERSITAETSKLINIKUM FREIBURG","We have identified a novel family of potent small molecule activators of the NLRP3 inflammasome. The goal of this project is to determine the feasibility of developing these new immunostimulators into an attractive commercial proposition. Establishment of technical feasibility will involve identification the most promising modifications of our drug candidates and testing their efficacy in disease models of cancer and immunization. In addition, we will determine commercial feasibility by conducti",{"id":542,"funder":7,"programme":8,"title":543,"piName":10,"institution":544,"country":312,"year":13,"amount":14,"abstract":545},"cordis-european-research-council-award-966696","High Level Synthesis for Machine Learning","ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE","With Deep Learning becoming ubiquitous in our life, running Deep Learning algorithms in real time on an heterogeneous set of hardware platforms is a pressing need in many aspects of our society. While traditional workflows based on standard CPUs and GPUs are established, Deep Learning inference on low-power devices (e.g., cars, smart phones, watches, etc) is gaining more attention. Typically, this would require strong background in electronic engineering to convert a neural network into a Digita",{"id":547,"funder":7,"programme":8,"title":548,"piName":10,"institution":549,"country":107,"year":13,"amount":14,"abstract":550},"cordis-european-research-council-award-966693","Novel Prognostic Personalized Biomarker and  Therapeutic Target in Blood Cancer Related Fibrosis","ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM","The objective of this ERC Proof of Concept is to demonstrate the clinical application and commercial viability of a specific driver of the innate immune system as a novel predictive biomarker and as a novel therapeutic target for the diagnosis and treatment of bone marrow fibrosis related to blood cancer. This proposed project builds upon recent findings of my deFiber ERC Starting Grant (Stg) project, where we identified this danger-associated molecular pattern complex as exactly as such a progn",{"id":552,"funder":7,"programme":8,"title":553,"piName":10,"institution":554,"country":45,"year":13,"amount":14,"abstract":555},"cordis-european-research-council-award-966772","A discovery tool for accelerated adsorption-diffraction analysis of dynamic adsorbents in gas separation","TECHNISCHE UNIVERSITAET DRESDEN","Synchrotron instrumentation plays a key role in the discovery of novel high performance materials. However, their application is limited to beam time available at large synchrotron facilities. The transfer of synchrotron based methods to a wider market of laboratory instrumentation poses significant market potential for SMEs and promotes accelerated materials discovery in industry. Responsive porous materials such as metal-organic frameworks are already recognized as highly selective adsorbents ",{"id":557,"funder":7,"programme":8,"title":558,"piName":10,"institution":165,"country":12,"year":13,"amount":14,"abstract":559},"cordis-european-research-council-award-874966","Development of an accurate, early diagnostic tool for ovarian cancer","Every year, ovarian cancer (OC) kills more than 40 000 women in Europe and 150 000 worldwide. In large part this is due to the fact that most women are not diagnosed until advanced stages. There is an urgent unmet clinical need for screening tools for the early, accurate identification of OC. OC is associated with alterations in glycosylation of secreted glycoproteins, and as such, they can serve as early OC biomarkers. However, this knowledge has still not been translated into clinic due to the",{"id":561,"funder":7,"programme":8,"title":562,"piName":10,"institution":563,"country":312,"year":13,"amount":14,"abstract":564},"cordis-european-research-council-award-966764","An in-memory dataflow accelerator for deep learning","IBM RESEARCH GMBH","Deep neural networks (DNNs), loosely inspired by biological neural networks, consist of parallel processing units called neurons interconnected by plastic synapses. By tuning the weights of these interconnections, these networks are able to perform certain cognitive tasks remarkably well. DNNs are being deployed all the way from cloud data centers to edge servers and even end devices and is projected to be a tens of billion Euro-market just for semiconductor companies in the next few years. Ther",{"id":566,"funder":7,"programme":8,"title":567,"piName":10,"institution":568,"country":12,"year":13,"amount":569,"abstract":570},"cordis-european-research-council-award-840626","Novel vascular-like BBB-on-a-chip","THE UNIVERSITY OF NOTTINGHAM","€149,951","There is great need to develop safer and more biologically relevant models for drug screening. Recent reports indicate that up to 20% of acute kidney complications can be linked to drug-induced nephrotoxicity and more than 40 molecules found to reduce Alzheimer’s Disease (AD)-related plaques in animal models were shown to be ineffective in AD patients. It is increasingly evident that both in vitro and in vivo models being used to develop drugs have a limited capacity to predict the pathophysiolo",{"id":572,"funder":7,"programme":8,"title":573,"piName":10,"institution":336,"country":192,"year":13,"amount":14,"abstract":574},"cordis-european-research-council-award-963924","Fair, Effective, and Sustainable Talent Management using Conditional Network Embedding","The ongoing industrial revolution is the driver of a rapidly advancing shift in the division of labour between humans on the one hand and machines and algorithms on the other. This is the cause of significant challenges in the job market, such as the emergence of important skills gaps that need to be addressed by extensive upskilling or reschooling of workers. This requires considerable forethought and hence insight into the future job markets, as well as an understanding of how to best meet the",{"id":576,"funder":7,"programme":8,"title":577,"piName":10,"institution":306,"country":262,"year":13,"amount":14,"abstract":578},"cordis-european-research-council-award-963391","Boosting Confocal Microscopes by Quantum Image Scanning Microscopy","The goal of the QuISM project is to develop an add-on module for confocal microscopes which will enhance the spatial resolution of the microscope by up to a factor of 4 and provide quantitative fluorescence imaging, taking advantage of the Quantum-assisted Image Scanning Confocal method recently developed within the frame of the ColloQuantO ERC-CoG project.Image-scanning confocal microscopes (ISM), proposed several decades ago and demonstrated for the first time in 2010 are already a commercial ",{"id":580,"funder":7,"programme":8,"title":581,"piName":10,"institution":582,"country":28,"year":13,"amount":14,"abstract":583},"cordis-european-research-council-award-963862","Commercial feasibility of a therapeutic approach to cancer based on ‘LEGO’ antibody recruiting glycodendrimers","UNIVERSITE GRENOBLE ALPES","Cancer remains a major cause of mortality worldwide, with projections estimating that 40% of population will be diagnosed with a form of cancer during their lifetime. Despite significant progress in treatment modalities, current therapeutic regimens are still deficient due to intolerable side effects, while stray cancer cells often escape destruction. Immunotherapy-based approaches certainly represent the most promising alternatives in this area although very limited approaches are available. In",{"id":585,"funder":7,"programme":8,"title":586,"piName":10,"institution":587,"country":69,"year":13,"amount":14,"abstract":588},"cordis-european-research-council-award-957466","Clinical translation of a novel CD1a-directed CAR for relapse\u002Frefractory cortical  T-cell Acute Lymphoblastic Leukemia: feasibility, efficacy and safety","FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS","Immunotherapy has revolutionized cancer treatment over the last decade. Adoptive cell immunotherapy with T-cells genetically redirected to a tumor-specific antigen using a chimeric antigen receptor (CAR) has achieved impressive response rates in advanced B-cell acute lymphoblastic leukemia (B-ALL). CAR T-cell strategies beyond B-cell tumors are, however, hampered by expected toxicities, owing to the lack of bona fide therapeutic and safe antigens. Indeed, there are no immunotherapeutic therapies",{"id":590,"funder":7,"programme":8,"title":591,"piName":10,"institution":228,"country":118,"year":13,"amount":14,"abstract":592},"cordis-european-research-council-award-966778","One-step switchable fluorescent probe assay for direct virus detection.","Since March 2020, the world is facing the Covid-19 pandemic. As of September 2020, over 900 000 people have died of the disease, caused by the SARS-CoV-2 virus. The WHO recommendations in order to limit the spread of the virus are to “test, trace and isolate”. To be successful, this strategy requires fast and massive testing. Today, tests are performed using PCR, a resource-intensive process requiring extraction of the viral RNA before nucleic acid amplification. PCR tests are slow (several hour",{"id":594,"funder":7,"programme":8,"title":595,"piName":10,"institution":596,"country":12,"year":13,"amount":14,"abstract":597},"cordis-european-research-council-award-963992","Synthetic Viral Nanosystem for Highly Efficient AAV Manufacturing for Gene Therapy","UNIVERSITY OF BRISTOL","Gene therapy is one of the most innovative and fastest growing fields in the pharmaceutical industry. The first approved gene therapy utilized a recombinant AAV vector (rAAV), and dozens of additional rAAVs for gene therapy are presently in clinical trials. rAAV gene therapy drugs have been priced in the region of € 500’000 and above, which is partially a result of them being manufactured by highly complex processes combining multiple components, requiring 5-7 separate GMP production runs. 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