[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-proof-of-concept-2022":3,"awarded-stats-erc-proof-of-concept":945},{"awarded":4,"total":944},[5,16,22,28,34,40,45,50,56,62,66,70,75,81,87,92,97,101,106,112,117,121,126,131,136,141,146,150,155,161,166,172,176,181,185,190,195,199,204,208,213,218,223,227,231,236,241,247,251,256,261,265,270,276,280,284,288,292,298,303,308,313,317,322,326,331,336,342,347,351,357,362,366,371,375,380,385,389,393,397,402,406,410,415,420,424,429,434,439,444,448,453,458,463,467,472,476,481,486,492,498,503,508,514,519,524,529,534,538,543,548,553,557,561,566,570,574,579,584,588,592,597,602,607,611,616,621,625,630,635,640,644,649,653,658,663,668,673,679,683,688,692,696,701,705,709,713,717,721,725,730,735,740,744,748,752,756,760,765,770,774,779,783,787,791,796,801,806,810,815,820,824,828,832,836,840,844,849,853,858,862,866,870,875,879,883,888,892,897,902,907,912,916,920,924,928,932,938],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-101060441","European Research Council","ERC Proof of Concept","Setting the Scene. Developing a Policy Agency for Sustainable Forms of Media Tourism",null,"ERASMUS UNIVERSITEIT ROTTERDAM","NL",2022,"€150,000","This project focuses on media tourism: the phenomenon of people travelling to places associated with movies, television series and other forms of popular culture. Media tourism has gradually evolved into a multi-million-dollar industry, with far-reaching implications for the related locations, affecting their economy, environment and community. As a result, city governments increasingly seek strategies to manage both the positive and negative impacts of these often-capricious media and tourism f",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":20,"year":13,"amount":14,"abstract":21},"cordis-european-research-council-award-101069291","Training Alone to Play Together App","CEU GMBH","AT","Making music together requires not only individual skills and musical expertise, but the ability to coordinate one's actions with others. Typically, musicians try to improve their joint performances by practicing together. However, musicians encounter two kinds of obstacles when trying to improve their joint music making skills. One obstacle is the lack of sufficient opportunities for joint rehearsal. The other obstacle is the lack of research-guided exercises that would allow for learning trans",{"id":23,"funder":7,"programme":8,"title":24,"piName":10,"institution":25,"country":26,"year":13,"amount":14,"abstract":27},"cordis-european-research-council-award-101059685","Designing green and energy-efficient anti-dewetting protocols for liquid chromatography","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","IT","High Performance Liquid Chromatography (HPLC) is the leading separation technology in research and industry, which often relies on potentially hazardous and environmentally harmful organic solvents. Water is the ideal environmentally friendly mobile phase, which would open the way to green HPLC. However, its broad applicability is hindered by the phenomenon of dewetting of the stationary phase – the formation of bubbles in the hydrophobic nanoporous material – which makes it unavailable to the s",{"id":29,"funder":7,"programme":8,"title":30,"piName":10,"institution":31,"country":32,"year":13,"amount":14,"abstract":33},"cordis-european-research-council-award-101069165","Reactive Synthesis in Action","TEL AVIV UNIVERSITY","IL","Bugs in software systems pose a huge and growing cost on society, not only in economic terms but also in direct risk to human lives. Reactive synthesis is a new technology to automatically generate correct-by-construction software. Unlike testing and formal verification, which require advance investment in an implementation, reactive synthesis generates a correct implementation directly from its formal specification.Despite its potential to reduce software development costs and at the same time ",{"id":35,"funder":7,"programme":8,"title":36,"piName":10,"institution":37,"country":38,"year":13,"amount":14,"abstract":39},"cordis-european-research-council-award-101069228","Exploitation of extreme cavitation conditions for wastewater treatment","UNIVERZA V LJUBLJANI","SI","One of the most pressing global problems is the increasing pollution of surface and groundwater, which threatens the world's clean water supply and public health. Wastewater treatment plants (WWTPs), the last barrier between ever-increasing human activities and the environment, produce huge amounts, up to 13 million tonnes per year in the EU alone1, of unwanted semi-solid by-product - waste activated sludge (WAS). Therefore, upgrading wastewater (WW) processes with new circular economy approache",{"id":41,"funder":7,"programme":8,"title":42,"piName":10,"institution":43,"country":32,"year":13,"amount":14,"abstract":44},"cordis-european-research-council-award-101069186","Diagnostic Screening Platform to Facilitate Conflict Resolution","BAR ILAN UNIVERSITY","MultiDoor is a digital platform based on conflict resolution and machine learning expertise to address the comprehensive needs of litigants and recommend their best way forward to resolve their disputes. At present, litigants attempting to navigate through the civil justice system end up drifting through an incoherent, opaque process generally resulting in some form of reluctant compromise. While court systems worldwide are investing much effort to increase efficiency, a human-centred approach, ",{"id":46,"funder":7,"programme":8,"title":47,"piName":10,"institution":48,"country":20,"year":13,"amount":14,"abstract":49},"cordis-european-research-council-award-101069203","Bulk rare earth free permanent magnets","OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN","Permanent magnets are essential components of an enormous amount of consumer and industrial products. Their production rises annually, especially due to their use in fast growing green technologies such as electric mobility. High performance magnets with a large energy product are usually based on the NdFeB material system. The major components are rare-earth elements, which are listed as critical materials. Novel permanent magnets use the concept of magnetic coupling effects. In course of the E",{"id":51,"funder":7,"programme":8,"title":52,"piName":10,"institution":53,"country":54,"year":13,"amount":14,"abstract":55},"cordis-european-research-council-award-101069312","ViEWS – a political Violence Early Warning System","INSTITUTT FOR FREDSFORSKNING","NO","This application presents a plan to explore the societal potential and financial viability of ViEWS – a political Violence Early WarningSystem, which has been developed as part of the ERC-AdG project no. 694640 at the Department of Peace and ConflictResearch, Uppsala University, and Peace Research Institute Oslo (PRIO). It is a rigorous and transparent prediction system of unprecedented scope and performance that is positioned at the forefront of research on theoretical and methodological founda",{"id":57,"funder":7,"programme":8,"title":58,"piName":10,"institution":59,"country":60,"year":13,"amount":14,"abstract":61},"cordis-european-research-council-award-101069356","Nano-Biological Contrast Agent Platform for MRI Imaging","ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE","ES","NANO-IMAGING proposes the elucidation of the potential of a metal-protein hybrid nanostructure as a platform for the development of tissue-specific positive Magnetic Resonance Imaging (MRI) contrast agents. This proposal builds on the large demand for MRI examinations worldwide, the health concerns raised by available contrast agents, and the little choice of tissue-specific contrast agents available to clinical practitioners.The unique value proposition of NANO-IMAGING —a safe, bright, and tiss",{"id":63,"funder":7,"programme":8,"title":64,"piName":10,"institution":31,"country":32,"year":13,"amount":14,"abstract":65},"cordis-european-research-council-award-101061890","Detection of pedestrians and cyclist outside a line of sight","The number of road accidents continue to increase dramatically each year. Cyclists and pedestrians, being a part of the daily traffic, keep challenging drivers thus making safety issues increasingly important. Furthermore, miniature electrical vehicles, paving their way through traffic and being in many cases unseen by drivers, put themselves in danger. Improving driving safety, being always a subject to technological efforts, is one of the most important challenges of the modern society. Contin",{"id":67,"funder":7,"programme":8,"title":68,"piName":10,"institution":31,"country":32,"year":13,"amount":14,"abstract":69},"cordis-european-research-council-award-101066138","A Real-time imaging and classification system for low-grade glioma detection during brain surgery","Brain tumors remain one of the most incurable illnesses we know; patients have poor prognosis and less than a decade of life expectancy. The oncologist’s toolkit is rather limited as chemotherapy agents have limited access to the brain due to the blood brain barrier selective permeability and radiotherapy results in extensive damage to tissue well beyond the targeted area; leaving surgical removal of the tumor as the most effective approach. It has now become clear that the completeness of the s",{"id":71,"funder":7,"programme":8,"title":72,"piName":10,"institution":73,"country":12,"year":13,"amount":14,"abstract":74},"cordis-european-research-council-award-101062032","Bioactive Tissue Sealant for Enhanced Wound Repair","UNIVERSITEIT TWENTE","Wound management is a routine part of medical practices worldwide, and delays in healing cause a significant clinical and economic burden. Current tissue sealant formulations that are used for wound care pose various limitations, including inability for filling in larger defects and release of toxic by-products (especially from synthetic polymers). Additionally, most of the commercial sealants provide no bioactive properties, or at best rely on bulk GF loading for inducing cell infiltration or t",{"id":76,"funder":7,"programme":8,"title":77,"piName":10,"institution":78,"country":79,"year":13,"amount":14,"abstract":80},"cordis-european-research-council-award-101069429","A microRNA-regulated cell death-inducing gene therapy for T-cell Acute Lymphoblastic Leukemia","FUNDACAO GIMM - GULBENKIAN INSTITUTE FOR MOLECULAR MEDICINE","PT","T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy. Although outcome has improved throughout the years with the use of combined chemotherapy, the aggressive regimens required for treatment efficacy often lead to significant short- and long-term side effects. Moreover, a significant fraction of T-ALL patients relapse, which have extremely poor prognosis. The current project aligns with the core goal of our ERC Consolidator Grant IL7sigNETure (CoG-648455) to gene",{"id":82,"funder":7,"programme":8,"title":83,"piName":10,"institution":84,"country":85,"year":13,"amount":14,"abstract":86},"cordis-european-research-council-award-101069244","Smart Battery Manufacturing Research and Development Assistant based on Augmented Reality Technology and powered with the ARTISTIC project Computational Models","UNIVERSITE DE PICARDIE JULES VERNE","FR","The SMARTISTIC project aims at developing and demonstrating a first prototype of a smart and interactive Augmented Reality (AR) software designed to assist in the decision-making of battery scientists, engineers and operators while they are working in electrode formulation and manufacturing in laboratories or in production lines. The software will be usable from tablets and AR glasses by touch gesture and hand gesture respectively. The software will blend holograms with the real world manufactur",{"id":88,"funder":7,"programme":8,"title":89,"piName":10,"institution":90,"country":60,"year":13,"amount":14,"abstract":91},"cordis-european-research-council-award-101069333","Development of a first-in-class inhibitor of FIH for cancer immunotherapy","ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS","We plan to carry out a valorisation project for a series of novel small molecule inhibitors of Factor Inhibiting HIF (FIH) that we have developed for the treatment of lung cancer, as a next-generation therapeutic approach in the field of immuno-oncology.The valorisation plan will include: clarification of IP rights and strategy, establishing contacts with potential investors and pharma partners, and verification of the potential of start-up creation. Moreover, valorisation activities will includ",{"id":93,"funder":7,"programme":8,"title":94,"piName":10,"institution":95,"country":60,"year":13,"amount":14,"abstract":96},"cordis-european-research-council-award-101069213","Operational Heat-Health-Social Early Warning System","FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA","Ambient temperatures are associated with more than 5 million annual deaths globally, 300,000 of which in Western Europe alone. Many European countries have implemented heat early warning systems, but they are generally based on temperature thresholds from weather forecasts that do not account for the inequalities in vulnerability of the exposed populations. This ERC-funded project will create the first operational Heat-Health-Social Early Warning System (HHS-EWS) by integrating weather forecasti",{"id":98,"funder":7,"programme":8,"title":99,"piName":10,"institution":73,"country":12,"year":13,"amount":14,"abstract":100},"cordis-european-research-council-award-101069263","Skin micro-injector","Needle-based injections are very common in modern medicine, notably in ongoing vaccination efforts worldwide. However, needle phobia and infection risks affect patient compliance with medical treatments, while millions of used needles contaminate the environment. Lastly, the effectiveness of certain drugs increases when injected intradermally, but targeting the dermis is challenging. Thus, new minimal-invasive procedures are needed. Jet injectors are needle-free medical devices that pressurize t",{"id":102,"funder":7,"programme":8,"title":103,"piName":10,"institution":104,"country":60,"year":13,"amount":14,"abstract":105},"cordis-european-research-council-award-101069391","Versatile Polypeptide-based Intranasal Drug Delivery Platform(s) to Tackle CNS Disorders.","FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPE FELIPE","Nearly one in six of the world's population suffered from neurological disorders, this number is expected to keep growing. Many of those central nervous system (CNS) disorders do not have still an approved therapy, mainly due to one of the most challenging barriers, the blood-brain barrier (BBB). Only 2% of small-molecule drugs and ~0% of biologic drugs can reach the brain, thus stunting the development of treatment options. In POLYBRAINT we will explore the technical and commercial feasibility ",{"id":107,"funder":7,"programme":8,"title":108,"piName":10,"institution":109,"country":110,"year":13,"amount":14,"abstract":111},"cordis-european-research-council-award-101069459","Targeting bicarbonate transport as a “first-in-class” therapeutic strategy to promote CD8+ T cell fitness and enhance cancer immunotherapy","VIB VZW","BE","Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancer types. It is virtually resistant to any sort of therapy, including the most recent immunotherapies. These tumors are characterized by a strong hypoxic, nutrient poor, and acidic tumor microenvironment (TME), in which cytotoxic CD8+ T cells are excluded or absent. In the context of tumor acidity, the role of bicarbonate transporters, key regulators of pH homeostasis, has mostly been neglected so far. Supported",{"id":113,"funder":7,"programme":8,"title":114,"piName":10,"institution":115,"country":110,"year":13,"amount":14,"abstract":116},"cordis-european-research-council-award-101069447","High Speed Communication Links Based on Heterogeneous Chips","UNIVERSITEIT GENT","The constant hunger for data is straining optical links causing optical chip makers to struggle. Transceivers have to work at everincreasing symbol rates. On top they need to handle more complex data formats. New materials have to be sought after as current modulator technologies in e.g. silicon are reaching their limit. In the COMb project, we will leverage recently obtained results to make ultra-high-speed transceivers based on the multi-material integration of Indium Phosphide and Lithium Nio",{"id":118,"funder":7,"programme":8,"title":119,"piName":10,"institution":73,"country":12,"year":13,"amount":14,"abstract":120},"cordis-european-research-council-award-101069261","Printing Electro-Tomography","3D printing is literally building our future in realising components and parts which cannot either be manufactured with standard techniques (milling, lathing) or for which the scale does not justify the use of molding techniques which require longer time and are only convenient for a high production scale. The problem with current 3D printing is the tradeoff between speed and precision: if we want to print fast in additive manufacturing, it is more difficult to know what physically happens with ",{"id":122,"funder":7,"programme":8,"title":123,"piName":10,"institution":124,"country":32,"year":13,"amount":14,"abstract":125},"cordis-european-research-council-award-101069201","From near extinction to market distinction: Developing a methodology for the sustainable revival of heritage grapevine cultivars","UNIVERSITY OF HAIFA","Wine grapes (Vitis vinifera) are among the most sensitive crop to global warming. Elevated temperatures lessen the quality of the grapes and alter their distinctive traits. The threat is pushing winegrowers in Europe to look for new cultivars with greater resilience to climate change. Arid regions with longstanding winegrowing traditions are ideal for locating endemic grapevines that are resilient to high temperatures. With its storied history of sustainable dryland viticulture, the Negev desert",{"id":127,"funder":7,"programme":8,"title":128,"piName":10,"institution":129,"country":110,"year":13,"amount":14,"abstract":130},"cordis-european-research-council-award-101067623","Column with AC-EOF Induced Vortices for HPLC","VRIJE UNIVERSITEIT BRUSSEL","In most high-performance analytical instruments, which are used to carry out blood analysis, for example, the first step is separation, in which the various components in a sample to be examined are divided into groups before being presented to a detector. Further improvement  of the process is limited due to the  slow spontaneous transport of the components in the traditionally exploited, naturally occurring, diffusion process.In the context of ERC Starting Grant EVODIS, the µFlow group of Prof",{"id":132,"funder":7,"programme":8,"title":133,"piName":10,"institution":134,"country":60,"year":13,"amount":14,"abstract":135},"cordis-european-research-council-award-101069217","Short-wave Infrared Light emitters based on Colloidal Quantum Dot Technology","FUNDACIO INSTITUT DE CIENCIES FOTONIQUES","Optical sensing and imaging has evolved from taking digital images to a powerful metrology, imaging and data acquisitiontechnique by expanding the spectral coverage from the visible to the short-wave infrared (SWIR). SWIR sensing andimaging is the cornerstone of advanced imaging techniques for 3D visualization, night vision, imaging though adverseweather conditions, biomedical imaging, spectroscopy for food quality and health monitoring, just to name a few. The hugemarket size of such applicatio",{"id":137,"funder":7,"programme":8,"title":138,"piName":10,"institution":139,"country":32,"year":13,"amount":14,"abstract":140},"cordis-european-research-council-award-101069322","Colloidal Quantum Dot Molecules for Display Applications","THE HEBREW UNIVERSITY OF JERUSALEM","Displays are all around us. They are in smartphones, laptops, TVs, and cars and have become entwined in our everyday life with new features being added, such as the Augmented Reality technology. The market strives for constant improvement in display technology performance, with better colors, thinner formats, and new functionalities. The market share of Quantum Dot (QD) displays is constantly growing because of the pure colors emitted from colloidal semiconductor nanocrystals which enable a more",{"id":142,"funder":7,"programme":8,"title":143,"piName":10,"institution":144,"country":26,"year":13,"amount":14,"abstract":145},"cordis-european-research-council-award-101069397","Targetting neutrophil-mediated neurotoxicity for the treatment of Alzheimer's Disease","UNIVERSITA DEGLI STUDI DI VERONA","With the NeutrAD ERC PoC project, we present the first disease-modifying Alzheimers Disease (AD) drugs that abrogate leukocyte-mediated neurotoxicity and represent a novel class of drugs in the treatment of AD.AD is a neurological disorder characterized by progressive deterioration of cognitive function and leads to death within 3-9 years after diagnosis. AD is highly prevalent in elderly, and it is estimated that 35M patients suffer from the disease worldwide. As a result, AD has tremendous soc",{"id":147,"funder":7,"programme":8,"title":148,"piName":10,"institution":73,"country":12,"year":13,"amount":14,"abstract":149},"cordis-european-research-council-award-101069232","Sustainable and HIgh Performance MEmbranes via iNTerfacial complexation (SHIPMENT)","Membrane technology is a very sustainable approach to separation, as it requires much less energy than conventional separation approaches. But the sustainable image of membranes becomes substantially tarnished when you realize that nearly all membranes are prepared using large quantities of toxic and unsustainable aprotic solvents (NMP, DMF etc). To secure the future of membrane technology, it becomes critical to develop more sustainable approaches to membrane fabrication. An Aqueous Phase Separ",{"id":151,"funder":7,"programme":8,"title":152,"piName":10,"institution":153,"country":12,"year":13,"amount":14,"abstract":154},"cordis-european-research-council-award-101069354","Developing a rating tool for APP SAfety (APPSAFE)","TILBURG UNIVERSITY- UNIVERSITEIT VAN TILBURG","This project aims to develop a new approach for rating mental health apps, taking into account the subjective needs of users in the mental health community. In particular, our aims are to show that 1) an automatic rating of safety in relation to mental health apps is possible, and 2) such an automatic rating system can take into account subjective needs of app users. Our goal is to build a prototype of an automatic rating system for affective safety, while also demonstrating the limitations of w",{"id":156,"funder":7,"programme":8,"title":157,"piName":10,"institution":158,"country":159,"year":13,"amount":14,"abstract":160},"cordis-european-research-council-award-101082050","AI-based Data Platform for Fair Social Policies","KOC UNIVERSITY","TR","The Politus Project will assess the commercial viability of proprietary natural language processing and machine learning technology for AI-based data-driven fair social policymaking. The project will verify the innovation potential of computational social science and policy-related novel methods from the PI’s ERC-funded Emerging Welfare Project (https:\u002F\u002Femw.ku.edu.tr). To deliver the technical and commercial proof of concept, the PI will establish the Politus Analytics Company, which will offer ",{"id":162,"funder":7,"programme":8,"title":163,"piName":10,"institution":164,"country":26,"year":13,"amount":14,"abstract":165},"cordis-european-research-council-award-101069299","Secure Hardware with AdvaNced NONvolatile memories","POLITECNICO DI MILANO","Over the recent years, the explosive growth of digital technologies allowed to implement disruptive business models driven by data collection and processing. In particular, the internet of things (IoT) opens unprecedented opportunities for consumers (smart society), organisations\u002Fcompanies (industry 4.0\u002F smart factories) and governments (smart nations). However, as every adoption of new technologies involves some risks, security attacks are amongst the most severe challenges for IoT: only in 202",{"id":167,"funder":7,"programme":8,"title":168,"piName":10,"institution":169,"country":170,"year":13,"amount":14,"abstract":171},"cordis-european-research-council-award-101057162","Photonic Spectrum Analyzer for the Terahertz Spectral Domain","TECHNISCHE UNIVERSITAT DARMSTADT","DE","Scientific and commercial utilization of the Terahertz spectrum (100 GHz -10 THz) is often hindered by the lack of affordable characterization tools for developing systems towards maturity. This proposal aims for the prototype development of such tools, namely  affordable spectrum analyzers (SA), in order to boost component development in the Terahertz domain (100 GHz-10 THz), particularly electronic and opto-electronic components. These are employed in 6G hardware, spectroscopy including bio-me",{"id":173,"funder":7,"programme":8,"title":174,"piName":10,"institution":169,"country":170,"year":13,"amount":14,"abstract":175},"cordis-european-research-council-award-101082333","Biophysical Genetic Design Automation Technology","Advances in our capabilities to program, synthesize and modify DNA has led to a surge in the field of synthetic biology. Various gene circuits have been proposed and designed in various organisms for application domains ranging from biomedicine over biotechnology to biomaterials. Our current bottleneck is not anymore our ability to program and synthesize custom DNA, but rather our ability to design regulatory circuit that realize the desired functionality and operate reliably in a specific targe",{"id":177,"funder":7,"programme":8,"title":178,"piName":10,"institution":179,"country":20,"year":13,"amount":14,"abstract":180},"cordis-european-research-council-award-101069277","Cohesin Therapeutics. Precision medicine for treating STAG2 mutated cancers","FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH","The cohesin gene STAG2 has emerged as a new tumour suppressor frequently mutated in bladder cancer, Ewing sarcoma and acute myeloid leukaemia (AML). Currently, these cancers are treated by cytotoxic therapies and surgery. These treatment plans are limited by unwanted side effects, have not been able to eliminate the high mortality caused by AML, and have not improved over the last few decades. STAG2 mutations are therefore a biomarker for cancer patients with high medical need. We discovered tha",{"id":182,"funder":7,"programme":8,"title":183,"piName":10,"institution":139,"country":32,"year":13,"amount":14,"abstract":184},"cordis-european-research-council-award-101082287","Clone-based full-length RNA-seq for early diagnosis of cancer","Intra-tumor genetic heterogeneity imposes a great challenge on cancer therapy. Resistance to molecularly targeted therapies and chemotherapy can arise from selective growth of pre-existing sub-clones that carries drug-resistance mutations, altered metabolic and\u002For epigenomic states, providing a survival advantages. Early detection of these subclonal states can thus significantly aid cancer therapy. However, attempts to profile various types of primary cancer cells using single-cell techniques ar",{"id":186,"funder":7,"programme":8,"title":187,"piName":10,"institution":188,"country":12,"year":13,"amount":14,"abstract":189},"cordis-european-research-council-award-101082238","Reversing the advantage of cancers with Hypoxia and Homologous Recombination Defect (HRD) by using a pan-cancer, composite, lesions-specific biomarker","UNIVERSITEIT MAASTRICHT","Hypoxia-activated prodrugs (HAPs) are a great concept in particular in association therapies more efficient on well-oxygenated cells, such as immunotherapies. CP-506 is a third generation HAP with optimal PK for which we confirmed in more than 20 tumor models that presence of tumor hypoxia is a requisite for prodrug activation. We already had an AI\u002Fradiomics-based proprietary IP on a solution to identify hypoxia from standard imaging. Another important determinant for efficacy was the presence o",{"id":191,"funder":7,"programme":8,"title":192,"piName":10,"institution":193,"country":170,"year":13,"amount":14,"abstract":194},"cordis-european-research-council-award-101082064","Pre-clinical development of a lentiviral gene therapy to treat hearing and balance loss in Usher 1B patients","MEDIZINISCHE HOCHSCHULE HANNOVER","The most prevalent genetic sensory defect, sensorineural hearing loss (SNHL), affects >430 million people and results in substantial financial and social consequences. Current treatment options are limited, achieving only temporary or partial relief and are restricted to a sub-group of patients. Therefore, novel treatment options are of high clinical need. Genetic mutations play a role in the majority of SNHL cases, which makes SNHL an ideal setting for innovative clinical gene therapy approache",{"id":196,"funder":7,"programme":8,"title":197,"piName":10,"institution":115,"country":110,"year":13,"amount":14,"abstract":198},"cordis-european-research-council-award-101101075","Targeting NLRP3-mediated inflammation with novel chemotypes","Inflammasomes play a vital role in in protecting humans against pathogenic microorganisms, harmful substances and cell changes that could result in illness. The NLRP3 inflammasome in particular attracts considerable interest because aberrant NLRP3 activation is a key pathogenic mechanism in many chronic inflammatory diseases. Moreover, gain-of-function mutations in NLRP3 causes a periodic fever syndrome named cryopyrin-associated periodic syndrome (CAPS). MCC950\u002FCRID3-based sulfonylurea compound",{"id":200,"funder":7,"programme":8,"title":201,"piName":10,"institution":202,"country":12,"year":13,"amount":14,"abstract":203},"cordis-european-research-council-award-101069237","Commercial feasibility of a cell-free reactor setup  for optimisation of complex enzymatic pathways","STICHTING RADBOUD UNIVERSITEIT","This project will explore the commercial feasibility of the first continuous stirred tank reactor solution for the synthetic replication and optimisation of complex enzymatic pathways. Our technology provides an urgently needed alternative for bioengineered organisms. Where normally raw materials of varying quality, competition between intermediates, toxicity, complex networks of feedback loops and other poorly understood factors limit production rates, our approach can be used to converge effec",{"id":205,"funder":7,"programme":8,"title":206,"piName":10,"institution":202,"country":12,"year":13,"amount":14,"abstract":207},"cordis-european-research-council-award-101082163","Development of carbohydrate based anticancer agents","CarboMed will assess the commercial viability of targeting cancer cell glycosylation as a next-generation therapeutic strategy to treat cancer in the clinic. Carbohydrates (glycans) coat the cell of every organism. The glycosylation pattern of cancer cells is, however, very different from that of healthy cells and is associated with aggressive and invasive forms of cancers. By combining our knowledge on carbohydrate chemistry and cancer immunology we targeted the cancer-cell protecting carbohydr",{"id":209,"funder":7,"programme":8,"title":210,"piName":10,"institution":211,"country":20,"year":13,"amount":14,"abstract":212},"cordis-european-research-council-award-101068557","Perovskite Oxides for CO2 Utilization – Industrial Applicability of Tailored reverse Water Gas Shift Catalysts","MONTANUNIVERSITAET LEOBEN","The catalytic reverse water-gas shift reaction (rWGS) will be a key technological process in the current effort to reduce the global CO2 emissions levels. It enables the utilisation of CO2 as an abundant and renewable carbon source and to transform flue gas into value added products. Coupling the rWGS reaction with renewable energy sources will facilitate the development of closed carbon cycles and to establish circular economy concepts.The main technological obstacles of implementing industrial",{"id":214,"funder":7,"programme":8,"title":215,"piName":10,"institution":216,"country":20,"year":13,"amount":14,"abstract":217},"cordis-european-research-council-award-101082277","Transient inactivation of hypothalamic hormone release to prevent post-traumatic stress sensitization","MEDIZINISCHE UNIVERSITAET WIEN","Stress is the foremost consequence of human life and became a pressing societal burden through the many sensory and societal pressures that have evolved during the past decades. Severe stress induces maladaptive changes in the brain that clinically manifest as post-traumatic stress disorder (PTSD). Despite ~4% of the population presenting PTSD, only symptomatic therapies are available. In the ’SECRET-CELLS’ ERC award, we have identified a multimodal neurocircuit that induces brain-wide sensitiza",{"id":219,"funder":7,"programme":8,"title":220,"piName":10,"institution":221,"country":170,"year":13,"amount":14,"abstract":222},"cordis-european-research-council-award-101069216","Linking genome variation with haplotype-resolved sequencing","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","DNA sequencing has transformed biological research, and is fast becoming the standard-of-care in medicine. Chances are good that every European person born today may have their genome sequenced at some point in their lifetime (it is already happening in Iceland). The currently prevailing sequencing platform, Illumina short-read sequencing, prioritizes content (DNA basepairs) over preserving long-range haplotype context. This decision has paid off so far, but comes at the cost of complicated anal",{"id":224,"funder":7,"programme":8,"title":225,"piName":10,"institution":164,"country":26,"year":13,"amount":14,"abstract":226},"cordis-european-research-council-award-101069181","Closed-Loop and multisEnsing delIvery tool for controlled Laser Ablation of tumors","The need of a minimally invasive alternative to traditional cancer surgery is pushing the global market of thermal ablation devices, mainly for treating delicate organs (brain, prostate, breast, pancreas, lung) in inoperable patients. With its fine and flexible applicator, laser ablation (LA) was successfully used in lesions difficult to access with conventional surgery, and its market is expected to show the highest growth rates in the next 5 years. However, crucial aspects and clinical needs a",{"id":228,"funder":7,"programme":8,"title":229,"piName":10,"institution":144,"country":26,"year":13,"amount":14,"abstract":230},"cordis-european-research-council-award-101069279","Prostate Diagnosis using Optical Coherence Tomography","With 1.3 million new cases worldwide, prostate cancer (PC) is the second most common cancer in men, causing more than 350,000 deaths each year. It is so common that about 1 man in 8 will be diagnosed with prostate cancer during his lifetime. As for any degenerative disease, early diagnosis is crucial to improve patients’ quality of life and reduce the mortality rate. However, the gold standard technique (biopsy) is affected by large diagnostic errors, representing a major limitation to achieve a",{"id":232,"funder":7,"programme":8,"title":233,"piName":10,"institution":234,"country":32,"year":13,"amount":14,"abstract":235},"cordis-european-research-council-award-101069387","Topological Insulator Vertical Cavity Laser Array","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","Vertical Cavity Surface Emitting Lasers (VCSELs) are tiny semiconductor lasers, structured as pillars of few-microns diameter on a chip, emitting light from their surface. They are now the most commonly used lasers, e.g., in cell phones, car sensors, data transmission in fiber optic networks. Though widely used, the miniscule size of VCSELs sets a stringent limit on the output power it can generate.  For years, scientists have sought to enhance the power emitted by such devices through combining",{"id":237,"funder":7,"programme":8,"title":238,"piName":10,"institution":239,"country":110,"year":13,"amount":14,"abstract":240},"cordis-european-research-council-award-101069401","Metal-Organic Framework Field-Effect Transistor Arrays for Chemical Sensing","KATHOLIEKE UNIVERSITEIT LEUVEN","Detecting volatile organic compounds (VOCs) at low concentrations is an important but challenging task with a range of applications, including checking food freshness, monitoring indoor air quality, and diagnosing lung conditions through breath analysis. In all of these areas, high-performance yet compact VOC sensors are needed. While compact VOC sensors exist, they suffer from limited lifetimes and low selectivities, and often produce questionable data. Metal-organic frameworks (MOFs) with pore",{"id":242,"funder":7,"programme":8,"title":243,"piName":10,"institution":244,"country":245,"year":13,"amount":14,"abstract":246},"cordis-european-research-council-award-101069416","REVEALing complex strain patterns and dangerous loads using cholesteric liquid crystal elastomers","UNIVERSITE DU LUXEMBOURG","LU","The Internet of Things (IoT), Industry 4.0, and the increased availability and performance of sensors have led to new generations of ‘smart’ products that can communicate real-time status information, improving energy balance, increasing safety, and opening for better, more seamless experiences for consumers. Mechanical sensors—often measuring strain—are key components in many scenarios. However, current technology typically employs point-based or one-dimensional (1D) strain sensors of resistive",{"id":248,"funder":7,"programme":8,"title":249,"piName":10,"institution":31,"country":32,"year":13,"amount":14,"abstract":250},"cordis-european-research-council-award-101100903","A Sonar Sensing System for Crop Yield Estimation","With the rapidly growing world population, accelerated climate changes and global migration, nutritional security is a major challenge. This situation calls for fast development and utilisation of agricultural technology that will push agricultural yield production to its full potential.Yield estimation in agricultural production is thus central for both agricultural planning as well as for successful agroeconomic management. Despite its importance, agricultural yield estimation is currently alm",{"id":252,"funder":7,"programme":8,"title":253,"piName":10,"institution":254,"country":26,"year":13,"amount":14,"abstract":255},"cordis-european-research-council-award-101069250","ELECTROCHEMICAL DNA-BASED SENSORS FOR IMMUNOTHERAPY MONITORING","ISTITUTO NAZIONALE DI BIOSTRUTTURE E BIOSISTEMI","During the initial part of the ERC-Consolidator Grant PRO-TOOLKITS we have successfully demonstrated a novel approach for antibodies detection. The platform uses antigen-conjugated synthetic DNA strand to achieve the rapid and inexpensive detection of target antibodies.  Our platform offers several advantages (low-cost, single-step, rapid) in comparison of other methods for antibody detection and is so versatile that can be used also for the detection of Bispecific Antibodies (BsAb). On the basi",{"id":257,"funder":7,"programme":8,"title":258,"piName":10,"institution":259,"country":79,"year":13,"amount":14,"abstract":260},"cordis-european-research-council-award-101082283","Flexible and transparent platform based on oxide transistors for detection and readout of ionizing radiation","NOVA ID FCT - ASSOCIACAO PARA A INOVACAO E DESENVOLVIMENTO DA FCT","Ionizing radiation presents a known health risk, but if used controllably it can be the basis of relevant applications spanning from healthcare to civil security. Either for proper control of the dose received by patients in medical treatments or workers in radiation hazardous environments, or for high resolution imagers, proper quantification of the radiation doses is demanded. The x-ray detectors market represented 2.5 Bn$ in 2020, and flexible\u002Fwearable X-ray detectors are seen as breakthrough",{"id":262,"funder":7,"programme":8,"title":263,"piName":10,"institution":139,"country":32,"year":13,"amount":14,"abstract":264},"cordis-european-research-council-award-101064696","Cell Rejuvenation Therapy for Age-related Macular Degeneration","Age-related macular degeneration (AMD) is a leading cause for blindness, resulting in loss of vision at the center of the visual field - the macula, due to damage to the retina. The disease, usually affecting older adults (>55), was diagnosed in 2020 in 196 million people worldwide, with an estimated economic toll of $343 billion including $255 billion in direct healthcare costs. In AMD, photoreceptors and retinal pigmented epithelium (RPE) cells which underlie the photoreceptors undergo degener",{"id":266,"funder":7,"programme":8,"title":267,"piName":10,"institution":268,"country":26,"year":13,"amount":14,"abstract":269},"cordis-european-research-council-award-101061820","Transparent conductive oxide nanocrYstalline films for eleCtronics and optoelectronics via low-cost solution prOcessing","POLITECNICO DI TORINO","TCOtronics project aims at developing and bridging to the market a revolutionary concept of a low-cost solution process to fabricate transparent conductive oxide-based films optimized for optical, electronic and optoelectronic applications. We will fabricate multilayer photonic structures, for filters and mirrors, and transparent electrodes for visible solar cells and transparent electronic circuits. We will employ only Earth-abundant elements. We will scale-up the fabrication process developing",{"id":271,"funder":7,"programme":8,"title":272,"piName":10,"institution":273,"country":274,"year":13,"amount":14,"abstract":275},"cordis-european-research-council-award-101069212","Black Widow Antivenom Innovation Necessity","DANMARKS TEKNISKE UNIVERSITET","DK","Widow spiders are spread worldwide, and their bite induces severe envenomation symptoms that can lead to a complex syndrome known as latrodectism and death in severe cases. The only available specific treatment consists of polyclonal antibodies derived from horse plasma obtained by hyperimmunization with black widow spider venom. However, this process is slow, dangerous, and implies the continuous use of large domestic animals (mainly horses) in the manufacturing process. Venom unavailability is",{"id":277,"funder":7,"programme":8,"title":278,"piName":10,"institution":273,"country":274,"year":13,"amount":14,"abstract":279},"cordis-european-research-council-award-101069404","Laboratory 3D micro X-ray diffraction","Essentially all materials microstructures are three-dimensional (3D). In spite of this, by far the most widely applied characterization tool is microscopy, which gives 2D images only. There is a need to go to 3D, and daily access to 3D measurements is required. Instruments that can be operated at home laboratories is thus the way forward.Our solution is to use newly developed and commercially available X-ray optics to focus the X-ray beam down to micrometer size in a laboratory X-ray instrument,",{"id":281,"funder":7,"programme":8,"title":282,"piName":10,"institution":273,"country":274,"year":13,"amount":14,"abstract":283},"cordis-european-research-council-award-101067399","Direct detection of coherent signals using Fano devices","This ERC PoC project aims to explore the commercial potential of a new and promising approach for realizing cheap integrated detectors with low energy consumption for use in high-speed interconnects, e.g. within datacenters. The innovative idea behind these new types of devices, denoted Fano Detectors, is based on high-quality research carried out under our ERC AdG “FANO”. Our long-term goal is to establish a start-up company and develop a transceiver product that can directly be sold to datacen",{"id":285,"funder":7,"programme":8,"title":286,"piName":10,"institution":221,"country":170,"year":13,"amount":14,"abstract":287},"cordis-european-research-council-award-101100608","Signal-enhanced MRI contrast agents for neurodegeneration","Despite decades of research, neurodegenerative diseases remain challenging to diagnose and identify on time. At the point external symptoms, such as memory or motor deficits become evident, the patient has usually suffered irreparable neuronal damage. This not only decreases life quality and expectancy of the patient, but also severely limits our ability to design new effective treatments and apply existing ones in a timely manner. A promising approach for early diagnosis could be the visualisat",{"id":289,"funder":7,"programme":8,"title":290,"piName":10,"institution":158,"country":159,"year":13,"amount":14,"abstract":291},"cordis-european-research-council-award-101100727","Wireless Stent-like Soft Millirobots (STENTBOT) for  Minimally Invasive Brain Vasculature Disease Treatments","Diseases in the brain vasculature, such as acute ischemic stroke, aneurysm and brain tumors, are fatal and require medical devices to treat them with minimal invasion. However, current tethered devices have limited safe access into the distal or tortuous vascular routes, which prevent saving lives of some patients. Therefore, we propose a wireless stent-shaped magnetic soft millirobot, stentbot, which would have the capability of safe access to such routes. Also, the stentbot will be able to be ",{"id":293,"funder":7,"programme":8,"title":294,"piName":10,"institution":295,"country":296,"year":13,"amount":14,"abstract":297},"cordis-european-research-council-award-101082223","Development of patient “Ossicle” for the personalized modelling of bone-developing cancers and therapeutic testing","LUNDS UNIVERSITET","SE","Cancer is a huge societal concern representing one death out of sixth in 2020. The vast majority of existing cancers emerge or ultimately develop in bones: leukemia, lung, breast, prostate, kidney, bladder. Our bones are thus considered a privileged harbor for cancer cells, and this is also associated with a very poor survival prognostic: bone-developing cancers account for ~3 million deaths each year. When at all existing, treatments are poorly effective: 92% of new therapies successful in prec",{"id":299,"funder":7,"programme":8,"title":300,"piName":10,"institution":301,"country":79,"year":13,"amount":14,"abstract":302},"cordis-european-research-council-award-101082210","Human based bioinks to engineer physiologically relevant tissues","UNIVERSIDADE DE AVEIRO","Bioprinting techniques, which integrate 3D printing with tissue engineering by using living cells encapsulated in natural or synthetic biomaterials as bioinks, are paving the way toward devising many innovating solutions for key biomedical and healthcare challenges and heralds' new frontiers in medicine, pharmaceutical, and food industries.HumanINK aims to validate human based-bioinks to produce robust humanized 3D environments with unprecedented biofunctionality for cell culture that fully reca",{"id":304,"funder":7,"programme":8,"title":305,"piName":10,"institution":306,"country":60,"year":13,"amount":14,"abstract":307},"cordis-european-research-council-award-101069363","COOLing electronic devices with GRAphene ELEctrons","FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA","Devices such as mobile phones, computers, and batteries have become an integrated part of our society. An important challenge in such devices and device components is to avoid overheating by using suitable thermal management. Currently, this typically relies on heat dissipation by electrons in metals such as copper. More recent approaches have explored heat dissipation by phonons in graphene and related materials, which can have a thermal conductivity that is an order of magnitude higher than th",{"id":309,"funder":7,"programme":8,"title":310,"piName":10,"institution":311,"country":60,"year":13,"amount":14,"abstract":312},"cordis-european-research-council-award-101069311","Research on Indigenous Data Governance Protocols: A toolkit for working with Indigenous Knowledge","UNIVERSITAT AUTONOMA DE BARCELONA","Data governance trends increasingly emphasize the need to open access to data, despite growing concerns over data privacy, control and surveillance. Indigenous peoples, with different epistemological traditions for the use and sharing of culturally sensitive information, add the additional concern of peoples ability to exert data sovereignty. Thus, while interest grow on the documentation and use of Indigenous knowledge, current data governance trends do not align well with Indigenous data right",{"id":314,"funder":7,"programme":8,"title":315,"piName":10,"institution":311,"country":60,"year":13,"amount":14,"abstract":316},"cordis-european-research-council-award-101069316","Rapid chip-based detection of antibiotic resistances","Drug-resistant infections are one of the greatest threats facing humanity. Antimicrobial resistance (AMR) causes over 700.000 deaths each year. Furthermore, AMR is associated to reduced quality of life, increased hospitalization periods and medical costs.  Misuse and over-prescription of antibiotics for human or animal treatment are one of the drivers of AMR.  At the same time, the development of new antibiotics is virtually nonexistent. Hence, developing fast diagnostic methods to identify the ",{"id":318,"funder":7,"programme":8,"title":319,"piName":10,"institution":320,"country":26,"year":13,"amount":14,"abstract":321},"cordis-european-research-council-award-101069319","Advanced Reduced order modellinG: Online computational web server for complex parametric Systems","SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE","The Proof of Concept Advanced Reduced order modellinG: Online computational web server for complex parametric SystemsARGOS wants to fulfil the demand of a Reduced Order Modelling Offline-Online tool, exploitable thanks to the creation of acomputational interface, handling and analysing a parametric problem in a very intuitive way. ARGOS is a computationalweb server hosting several web applications, some with a general purpose and some for very specific problems: users canaccess directly through ",{"id":323,"funder":7,"programme":8,"title":324,"piName":10,"institution":320,"country":26,"year":13,"amount":14,"abstract":325},"cordis-european-research-council-award-101069436","Morphing tubular structures for adaptive biomedical devices","Morphing tubular structures are extensively used in interventional medical devices (e.g., stents). Current solutions lack adaptability to complex geometries and to patient-specific needs. Stripe-oMorph proposes the use of devices with superior morphing capabilities, bio-inspired by motile microorganisms, previously investigated in the ERC AdG MicroMotility, and based on the concept of morphingby-sliding of parallel strips.",{"id":327,"funder":7,"programme":8,"title":328,"piName":10,"institution":329,"country":12,"year":13,"amount":14,"abstract":330},"cordis-european-research-council-award-101081818","Glycoengineered erythrocytes for better influenza vaccines","UNIVERSITEIT UTRECHT","The objective of this ERC PoC project is to establish technical and commercial feasibility of our recently developed glycan-engineered red blood cells (RBCs) for antigenic characterization of circulating influenza A\u002FH3N2 viruses. Due to the rapid evolution of influenza A\u002FH3N2 viruses, antigenic characterization by the widely used hemagglutination inhibition (HI) assay is not possible anymore. Continuous antigenic characterization of influenza A viruses is, however, essential for the development ",{"id":332,"funder":7,"programme":8,"title":333,"piName":10,"institution":334,"country":85,"year":13,"amount":14,"abstract":335},"cordis-european-research-council-award-101063037","A new device to analyse the regional variations of mechanical properties in cells and tissues:  prototyping and assessment of commercial potential for drug discovery applications","INSTITUT MINES-TELECOM","Mechanomics refers to the measurement of mechanical properties at the microscopic scale in biological tissues. Strong hopes are currently placed on mechanomics to evaluate quantitatively how a treatment or a gene expression affects the stiffness or strength of a tissue, with major impacts expected in drug discovery, diagnostics and genomics screening. However, there is a pressing need for new instrumentation technologies in mechanomics.In the BIOLOCHANICS ERC CoG project, we developed and valida",{"id":337,"funder":7,"programme":8,"title":338,"piName":10,"institution":339,"country":340,"year":13,"amount":14,"abstract":341},"cordis-european-research-council-award-101069293","Functionalized Graphene Based Electrode Material for Lithium Sulfur Batteries","UNIVERZITA PALACKEHO V OLOMOUCI","CZ","FunGraB project addresses the pressing need for ecofriendly, sustainable, and rechargeable batteries with high capacity, energy density, and long lifespan, which will significantly expand the energy storage market.With the rapid development and broad application of mobile devices, electric and unmanned vehicles, as well as with the rise of smart grids and networks for the internet of things, the demand for batteries with higher performance, lower cost, and lower environmental burden is rapidly g",{"id":343,"funder":7,"programme":8,"title":344,"piName":10,"institution":345,"country":20,"year":13,"amount":14,"abstract":346},"cordis-european-research-council-award-101069260","Fast Electro-Optic Fluorescence Lifetime Microscopy (EOFLIM) for super-resolution microscopy and brain surgery.","UNIVERSITAT WIEN","Fluorescence Lifetime Imaging Microscopy (FLIM) is a powerful method for monitoring physicochemical parameters of cells and tissues, as well as biomolecular interactions, with applications in science, medicine, and industry. However, its use is currently limited due to technological constraints regarding frame rate and sensitivity.We have developed a FLIM detector that enables highly sensitive, high-speed FLIM. It is based on the use of electro-optical elements as temporal gating units. Electro-",{"id":348,"funder":7,"programme":8,"title":349,"piName":10,"institution":345,"country":20,"year":13,"amount":14,"abstract":350},"cordis-european-research-council-award-101082020","Nanoscale spin-wave RF filters and multiplexers for 5G communication systems","Our everyday life is unimaginable without wireless information and communication technologies. Since 2019, 5G digital systems offer improved speed, bandwidth, and decreased energy consumption. Mobile operators invest $160 billion worldwide in the deployment of 5G each year. Over the last decades, RF filters based on Surface Acoustic Wave (SAW) occupied the entire market. But their usage for 5G high-band (26 GHz in EU) is impossible. Moreover, the utilisation of Bulk Acoustic Waves (BAWs) is stil",{"id":352,"funder":7,"programme":8,"title":353,"piName":10,"institution":354,"country":355,"year":13,"amount":14,"abstract":356},"cordis-european-research-council-award-101069400","Advanced Biopsychosocial Simulation for Harmful Adolescent Behaviour","HASKOLINN I REYKJAVIK EHF","IS","We, the LIFECOURSE team, have been developing a theoretical framework that combines biological, social, and psychological data into unified concepts over the past five years. We now have a combined biopsychosocial data framework that can be used to uncover and understand biosocial causal pathways to adolescent behaviour, including self-harm, suicide, substance-use, and delinquancy. To our knowledge, we possess the only linkage of high-quality biological, environmental, and social data across sev",{"id":358,"funder":7,"programme":8,"title":359,"piName":10,"institution":360,"country":54,"year":13,"amount":14,"abstract":361},"cordis-european-research-council-award-101100894","Versatile water vapour isotope calibration device (VISOR) for laboratory and field use","UNIVERSITETET I BERGEN","Climatic change will have large impacts on the global water cycle, and thus on hazardous weather and the availability of water to society. Earth observation from the ground and space is necessary to detect how and where the water cycle changes. The stable isotope composition of water vapour and precipitation is a sensitive indicator of ongoing and future water cycle changes. Continuous, ground-based observation of water vapour isotopes has recently become possible by the more widespread use of i",{"id":363,"funder":7,"programme":8,"title":364,"piName":10,"institution":139,"country":32,"year":13,"amount":14,"abstract":365},"cordis-european-research-council-award-101100628","Nano-Technology Enabled Repositioning of Cannabinoids for Treating NAFLD","Obesity is a catalyst for numerous conditions; the most notable is non-alcoholic fatty liver disease (NAFLD), for which currently no drug therapy has been approved by the FDA and EMA for its treatment. The endocannabinoid (eCB) system triggers the development of obesity and its related comorbidities, specifically NAFLD. eCBs, via activating the cannabinoid-1 receptors (CB1Rs) in the liver, increase hepatic glucose production, insulin resistance, and de novo lipogenesis, and decrease fatty acid o",{"id":367,"funder":7,"programme":8,"title":368,"piName":10,"institution":369,"country":340,"year":13,"amount":14,"abstract":370},"cordis-european-research-council-award-101082088","Single-fibre based holographic endoscope for observations of stroke in deep brain structure","USTAV PRISTROJOVE TECHNIKY AVCR VVI","The origin project LIFEGATE introduced the prospect of multimode fibre based holographic endoscope as a unique tool for high-resolution in-vivo imaging of structures residing deep inside the brain of animal models. It harnesses the power of controlled light transport through hair-thin MMFs to image and measure brain functions at single cell and sub-cellular level in virtually any brain structure, at unlimited depth and in uniquely atraumatic manner, thereby unlocking a variety of opportunities w",{"id":372,"funder":7,"programme":8,"title":373,"piName":10,"institution":31,"country":32,"year":13,"amount":14,"abstract":374},"cordis-european-research-council-award-101101071","Novel bio-inspired energy harvesting and storage all-in-one platform for implantable devices based on peptide nanotechnology","Over the past decades, implantable biomedical systems have greatly advanced, offering previously unavailable therapeutic options for millions of patients worldwide. Such applications most commonly utilize conventional lithium-ion batteries as the energy source. However, while readily providing adequate energetic performance, lithium-ion batteries are inflexible, rigid, may contain toxic substances, and require periodic replacement surgeries due to their limited capacity, posing both health risks",{"id":376,"funder":7,"programme":8,"title":377,"piName":10,"institution":378,"country":12,"year":13,"amount":14,"abstract":379},"cordis-european-research-council-award-101082241","Next Generation Polymyxin Antibiotics: Optimization and Validation","UNIVERSITEIT LEIDEN","In the NOVA ERC PoC project, we present a novel class of semi-synthetic polymyxins as an innovative solution to address the inherent toxicity of the polymyxins family of antibiotics. We here disclose the first candidate compounds of this novel family of antibiotics with potential for use as front-line treatment for multi-drug-resistant Gram-negative bacterial infections.Due to antimicrobial resistance (AMR), a resurgence in the use of polymyxin antibiotics has occurred over the last decade, desp",{"id":381,"funder":7,"programme":8,"title":382,"piName":10,"institution":383,"country":110,"year":13,"amount":14,"abstract":384},"cordis-european-research-council-award-101081162","Plasma Reactors for Efficient Fertilizer Production Applied in a Real Environment","UNIVERSITEIT ANTWERPEN","My project aims to demonstrate the proof of concept of new plasma reactors for sustainable and energy-efficient NOx production from air, as basis for green fertilizer production. Plasma is created by applying electricity, it is quickly switched on\u002Foff and has no economy of scale, so it is ideal in combination with renewable (intermittent) electricity, and thus, of interest for electrification of fertilizer production. This project originates from my ERC SyG, where we obtained record values in pl",{"id":386,"funder":7,"programme":8,"title":387,"piName":10,"institution":158,"country":159,"year":13,"amount":14,"abstract":388},"cordis-european-research-council-award-101100837","A GeoAI-based Land Use Land Cover Segmentation Process to Analyse and Predict Rural Depopulation, Agricultural Land Abandonment, and Deforestation in Bulgaria and Turkey, 1940-2040","Rural depopulation, agricultural land abandonment, and deforestation are massive concerns for Europe and elsewhere today and our planet's future. These interlinked phenomena can be analysed using land use and land cover (LULC) maps combined with dynamics of population geography, especially regarding urban sprawl. Modern LULC and spatially disaggregated population datasets go back to the 1980s and 1970s. Although we have earlier population data, these are not geomatched to locations in LULC maps.",{"id":390,"funder":7,"programme":8,"title":391,"piName":10,"institution":234,"country":32,"year":13,"amount":14,"abstract":392},"cordis-european-research-council-award-101081690","The development of a predictive biomarker for immunotherapy outcome based on flow cytometry test","Immunotherapy has revolutionised clinical oncology, with the use of immune checkpoint inhibitors (ICIs). These agents are in clinical use for almost a decade, treating over 20 types of cancers. They have shown a remarkable therapeutic benefit even in patients with advanced disease. Yet, only a small proportion of patients benefit from this therapy, leaving the rest resistant, for reasons that are still not clear. While there are certain clinical biomarkers to predict ICI therapy outcome, their p",{"id":394,"funder":7,"programme":8,"title":395,"piName":10,"institution":234,"country":32,"year":13,"amount":14,"abstract":396},"cordis-european-research-council-award-101069336","Real Processing in Phase Change Memory","Separation of processing and memory is the root cause of the main performance and energy bottlenecks in modern computers. In the PI's ERC Stg, we proposed to combine data processing and storage in the same cells, to develop a novel unit called the 'memristive memory processing unit' (mMPU). This unit was based on resistive RAM (RRAM), which is still not commercial in large capacity. A different memory technology, phase change memory (PCM), is commercially available in large capacity (for example",{"id":398,"funder":7,"programme":8,"title":399,"piName":10,"institution":400,"country":85,"year":13,"amount":14,"abstract":401},"cordis-european-research-council-award-101059469","To develop a new targeted therapy for the treatment of naive and PARP inhibitor-resistant BRCA1\u002F2-mutated tumors","INSTITUT CURIE","Breast and ovarian carcinomas are aggressive tumors with few treatment options and high recurrence rates. About half of these tumors shows defects in homologous recombination (HR) repair. Defect in HR (HRD) causes genomic instability and dependence on poly (ADP-ribose) polymerase (PARP)-mediated DNA repair. As a result, PARP inhibitors (PARPi) are now widely used for the treatment of these tumors. However, resistance to PARPi is emerging as the major obstacle to clinical effectiveness. Consequen",{"id":403,"funder":7,"programme":8,"title":404,"piName":10,"institution":188,"country":12,"year":13,"amount":14,"abstract":405},"cordis-european-research-council-award-101057070","The hydrocup: a hollow electrospun scaffold for in vivo cell-laden hydrogel delivery","Secreted cytokines by transplanted cells can have positive effects such as immunomodulation, angiogenesis and tissue regeneration. However, transplanted cells are difficult to retain in a specific place to maximize the release of cytokines on site. Here, we developed a hollow electrospun scaffold with one open and one closed end for the in vivo delivery of cells as ?secretory factories? in a hydrogel, termed the hydrocup. Because of the closed end, a (cell-laden) hydrogel can easily be dispensed",{"id":407,"funder":7,"programme":8,"title":408,"piName":10,"institution":188,"country":12,"year":13,"amount":14,"abstract":409},"cordis-european-research-council-award-101069433","Directed Orchestration of Microfluidic Environments for guided Self-organisation","In Europe, 263 per 10,000 pregnancies are diagnosed with a fetal congenital anomaly. Congenital anomalies, also referred to as birth defects, are defined as structural or functional disorders that occur during fetal development and are inherited, and\u002For caused by environmental factors. Unfortunately, the link between environmental factors, such as drugs, toxins or other chemicals, and the manifestation of these multifactorial disorders is poorly understood. To identify environmental factors affe",{"id":411,"funder":7,"programme":8,"title":412,"piName":10,"institution":413,"country":296,"year":13,"amount":14,"abstract":414},"cordis-european-research-council-award-101069390","Single molecule reconstruction for high-throughput, short-read sequencing technologies","KAROLINSKA INSTITUTET","Current advanced short-read sequencing technologies and third generation long-read sequencing technologies are still not capable of full molecule reconstruction in a high throughput manner due to their limited read length and throughput respectively.This project aims at bridging the gap between long reads and high throughput by developing a fragment labelling system compatible to high-throughput short-read Illumina sequencing technology. The labelling system consist of tags that can be incorpora",{"id":416,"funder":7,"programme":8,"title":417,"piName":10,"institution":418,"country":170,"year":13,"amount":14,"abstract":419},"cordis-european-research-council-award-101069308","Dry Powder Formulation of RNA Nanoparticles for Inhalation and Improved Storage and Transport Conditions","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","RNhale aims to establish technical and commercial proof-of-concept for our existing and protected protocols to be transformed into a platform technology with the long-term goal of licensing agreements with large pharmaceutical companies which are equipped for continuous manufacturing of large scales of dry powder RNA formulations.  RNhale will assess the commercial positioning of a platform technology for spray-drying RNA nanoparticles (NPs). While RNA medicines have revolutionized how we can ad",{"id":421,"funder":7,"programme":8,"title":422,"piName":10,"institution":115,"country":110,"year":13,"amount":14,"abstract":423},"cordis-european-research-council-award-101062689","LIQuid-crystal enabled Universal Optical  Reconfigurable Integrated Circuit Engineering","In LIQUORICE we will build an operational proof-of-concept of a general-purpose programmable photonic processor. This processor is intended to provide the photonics community with a flexible rapid prototyping technology, similar in use as an electronic FPGA, to stimulate new innovation and accelerate the adoption of photonic chip technology in diverse applications, beyond the traditional photonics markets of telecom and datacom. In particular, we want to test this new photonic chip for use in pr",{"id":425,"funder":7,"programme":8,"title":426,"piName":10,"institution":427,"country":26,"year":13,"amount":14,"abstract":428},"cordis-european-research-council-award-101081361","A web-platform interfaced software for spectroscopic molecular characterization and early diagnosis of Parkinson's disease","UNIVERSITA DEGLI STUDI DI MILANO","The goal of this proposal is the production of the SEMISOFT software and an associate web platform for spectroscopic molecular characterization and early diagnosis of Parkinson’s disease. SEMISOFT will be designed to decipher complex IR\u002FRaman spectra which are currently hampering development of new clinical protocols and other technological advances. This will be achieved upon implementation of the innovative semiclassically approximate quantum dynamics methods, developed in the parent ERC-CoG S",{"id":430,"funder":7,"programme":8,"title":431,"piName":10,"institution":432,"country":32,"year":13,"amount":14,"abstract":433},"cordis-european-research-council-award-101069457","Dynamical Recurrent Visual Perceiver","WEIZMANN INSTITUTE OF SCIENCE","Real-life applications of computer vision often require high-quality visual sensors. With current technology, such sensors are expensive. Empirical evidence from our ERC-funded research of biological vision suggests that eye motion enhances recognition capabilities beyond what could be expected if the eye was functioning as a static camera. Motivated by these findings, here we aim to perform the major computer vision tasks required for many real-life applications, including segmentation, classif",{"id":435,"funder":7,"programme":8,"title":436,"piName":10,"institution":437,"country":60,"year":13,"amount":14,"abstract":438},"cordis-european-research-council-award-101066321","Solid-State Ionics Synaptic Transistors for Neuromorphic Computing","FUNDACIO INSTITUT DE RECERCA EN ENERGIA DE CATALUNYA","Neuromorphic computing will revolutionize artificial intelligence for applications such as autonomous driving, smart diagnosis or natural-language understanding by emulating the operation of efficient biological neural networks. The main challenge in this field is the substitution of conventional transistors for synaptic transistors able to learn in ways similar to a neural synapse, i.e. the development of multistate non-volatile transistors. However, currently existing synaptic transistors have",{"id":440,"funder":7,"programme":8,"title":441,"piName":10,"institution":442,"country":296,"year":13,"amount":14,"abstract":443},"cordis-european-research-council-award-101069327","Artifical spider silk textiles","SVERIGES LANTBRUKSUNIVERSITET","ArtSilkTex builds on the ERC-funded project ARTSILK, in which we recently have  succeeded in 1) producing artificial spider silk on a scale that, for the first time, opens up the possibility of producing the material for industrial use and 2) inventing engineered spider silk proteins that can be spun into fibers with significantly enhanced mechancial properties. In this project we will manufacture artificial spider silk yarns that will be benchmarked against commonly used yarns on the market.  T",{"id":445,"funder":7,"programme":8,"title":446,"piName":10,"institution":164,"country":26,"year":13,"amount":14,"abstract":447},"cordis-european-research-council-award-101069171","Proton, electron And Neutron sources for non-destructive Testing ANd Investigations and treatment of materials","The main goal of the PANTANI project is to complete the design of an innovative laser-driven radiation source suitable for applications in materials science, inspection and treatment, as well as the development of some of its key components. Accelerators are exploited to produce particles and radiation needed for applications of high industrial and social relevance, like analysis of objects of historical, artistic and environmental interest, sterilisation of medical instrumentation, inspection o",{"id":449,"funder":7,"programme":8,"title":450,"piName":10,"institution":451,"country":296,"year":13,"amount":14,"abstract":452},"cordis-european-research-council-award-101064463","Photonic molecule microcombs","CHALMERS TEKNISKA HOGSKOLA AB","Frequency combs are remarkable photonic devices for precision frequency synthesis and metrology. The core technology behind conventional frequency combs is a mode-locked laser. Today, so-called microcombs constitute an alternative for the generation of a frequency comb on a chip-scale microresonator. Microcombs have a frequency separation between lines that is orders of magnitude larger than standard mode-locked lasers. The combination of small footprint and large line spacing is opening up enti",{"id":454,"funder":7,"programme":8,"title":455,"piName":10,"institution":456,"country":296,"year":13,"amount":14,"abstract":457},"cordis-european-research-council-award-101069424","SPINTOP","GOETEBORGS UNIVERSITET","There exists a class of important computational problems that conventional computers are unable to address with reasonable efficiency. Such Combinatorial Optimization (CO) problems are pervasive in a wide range of critically important sectors of society, e.g. in business operations, manufacturing, and research, including man-power scheduling, vehicle routing, IC circuit layout, protein folding and DNA sequencing, efficient big-data clustering, election modelling, network diagnosis, modelling mol",{"id":459,"funder":7,"programme":8,"title":460,"piName":10,"institution":461,"country":170,"year":13,"amount":14,"abstract":462},"cordis-european-research-council-award-101069246","Simplifying the SNAP-ADAR Tool for Broad Usage in Life Science Research and Drug Discovery","EBERHARD KARLS UNIVERSITAET TUEBINGEN","RNA base editing is a promising approach to manipulate genetic information in a transient and dosable way, which breaks new ground in basic Life Science research and drug discovery. In a preceding ERC CoG action, we have engineered the SNAP-ADAR tool, which allows for the particularly precise, efficient and programmable adenosine-to-inosine RNA base editing. However, the broad usage of this tool is somewhat hampered by the need for designing the chemically modified guideRNAs, which currently inc",{"id":464,"funder":7,"programme":8,"title":465,"piName":10,"institution":413,"country":296,"year":13,"amount":14,"abstract":466},"cordis-european-research-council-award-101069454","Highly multiplexed, quantitative protein biomarker profiling (hmqPro)","The project will develop a multipurpose, highly multiplexed, quantitative protein profiling (hmqPro) platform that can be adapted to a wide range of applications, particularly biomarker discovery. Biomarkers are a 43 Billion USD market spanning applications in diagnostics, drug discovery & development, personalized medicine, disease risk assessment. The method comprises an antibody-based profiling of a large number of proteins or protein posttranslational modifications against a large number of ",{"id":468,"funder":7,"programme":8,"title":469,"piName":10,"institution":470,"country":170,"year":13,"amount":14,"abstract":471},"cordis-european-research-council-award-101101069","nanoVAST: a novel, non- viral LNP for precision payload delivery of genome editors and other cargo","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","Cell-specific cargo delivery is a key remaining problem in the field of RNA-based therapeutics. Thus far, delivery has relied on lipid nanoparticles (LNPs) which encapsulate RNA with high efficiency, but broadly lack in specificity. Viral vectors are currently the only FDA approved tissue-specific cargo delivery option, with specificity being the result of manipulation of outer capsid proteins. However, viral systems are also associated with drawbacks such as oncogenicity, antigenicity and pre-e",{"id":473,"funder":7,"programme":8,"title":474,"piName":10,"institution":432,"country":32,"year":13,"amount":14,"abstract":475},"cordis-european-research-council-award-101069414","Modification of liposomic nano-carriers: a novel strategy for improved drug-delivery and eradication of bacterial biofilms","Bacterial biofilms are widespread, both as infections in humans and on devices that have come in contact with infected tissue, and pose a major health and economic burden. Such biofilms are difficult to treat as they present strong resistance to drug delivery, due to a dense, hydrated polysaccharide\u002Fprotein matrix in which the bacterial communities encase themselves, and from the bacterial membrane itself. Liposomes stabilized by poly(ethylene glycol), PEG moieties, the current gold-standard and",{"id":477,"funder":7,"programme":8,"title":478,"piName":10,"institution":479,"country":170,"year":13,"amount":14,"abstract":480},"cordis-european-research-council-award-101069214","Repurposing a human drug to treat Alzheimer’s disease","DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV","Alzheimer’s disease is a major cause of disability among older adults and represents substantial financial and human costs to patients, families and societies worldwide. Currently there is no cure for Alzheimer’s disease. Thus, novel effective treatments need to be developed that target the root causes of Alzheimer’s disease, in particular the pathogenic accumulation of the protein tau. During our ERC project, we achieved a breakthrough by demonstrating that an approved human drug efficiently in",{"id":482,"funder":7,"programme":8,"title":483,"piName":10,"institution":484,"country":170,"year":13,"amount":14,"abstract":485},"cordis-european-research-council-award-101068618","Cap analogs with a photo-cleavable group as a general reagent to produce light-activatable mRNAs as tool for fundamental and medical research","UNIVERSITAET MUENSTER","Messenger RNAs (mRNAs) have recently entered the stage as therapeutic modality. Examples are the mRNA-based vaccines against infection by SARS-Cov2. Hundreds of research groups in academia and industry aim to better understand the multiplicity of the mRNA technology and its possible applications. However, at present researchers are unable to control when and where the mRNA is translated into proteins – which then have a pharmacological effect. This is a bottleneck that severely limits the resear",{"id":487,"funder":7,"programme":8,"title":488,"piName":10,"institution":489,"country":490,"year":13,"amount":14,"abstract":491},"cordis-european-research-council-award-101069182","Light-reconfigurable substrate for cell cultures","TAMPEREEN KORKEAKOULUSAATIO SR","FI","L-Cell is a method for robust, reconfigurable control of surface topography, based on creating reversible light-induced surface structures onto azobenzene-containing bilayers. These light-reconfigurable substrates allow free-form topographical patterns to be created and subsequently erased over many cycles on a biocompatible cell culture substrate, even when the cells are already growing on the substrate. L-Cell aims at mimicking more closely the dynamic conditions in human body, which regulate ",{"id":493,"funder":7,"programme":8,"title":494,"piName":10,"institution":495,"country":496,"year":13,"amount":14,"abstract":497},"cordis-european-research-council-award-101069394","Building the First Automated Causal Discovery Platform","PANEPISTIMIO KRITIS","EL","Causal Discovery is desperately needed in both science and the industry, but it is largely inaccessible to non-experts. AutoCD proposes to create the first automated causal discovery software engine and explore its commercial exploitation. AutoCD will largely boost the productivity of experts as well as allow the application of causal discovery with minimal expertise. It will provide functionalities such as (a) induction of causal models and causal relations from data by automatically tuning the",{"id":499,"funder":7,"programme":8,"title":500,"piName":10,"institution":501,"country":60,"year":13,"amount":14,"abstract":502},"cordis-european-research-council-award-101069282","Antiviral Proteins Applied as Therapeutics in Aquaculture","UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE","In the last decades aquaculture seems to be the only real alternative for global fish food supply. At present, the aquaculture world production has reached 82.1 million tons worldwide representing the fastest growing animal production sector in the world. Among aquaculture species, salmonid aquaculture, trout and salmon species, are the highest-value species for global and European aquaculture. The biggest global constraint to aquaculture production is disease with an estimate of a 10% of all cu",{"id":504,"funder":7,"programme":8,"title":505,"piName":10,"institution":506,"country":170,"year":13,"amount":14,"abstract":507},"cordis-european-research-council-award-101101077","Single-Cell Metabolomics for Drug Discovery and Development","EUROPEAN MOLECULAR BIOLOGY LABORATORY","Despite the major efforts in the modern drug discovery and development, the field is still in its crisis with the productivity increasingly declining. A major source of drug development failure is the toxicity where the adverse drug reaction is often caused by off-target effects of drug candidates that can be revealed only late in the drug development process. Metabolomics was proposed as an emerging promising approach to monitor off-targets effects on metabolic enzymes or transporters thus prov",{"id":509,"funder":7,"programme":8,"title":510,"piName":10,"institution":511,"country":512,"year":13,"amount":14,"abstract":513},"cordis-european-research-council-award-101069207","Deep learning derived mechanical biomarkers for cancer therapy prediction","UNIVERSITY OF CYPRUS","CY","In the fight against cancer, it is well recognized that tumors are highly heterogeneous and they might differ considerably not only between tumors types but also among tumors of the same type or even for the same tumor during progression. As a result, the efficacy of standard cancer therapies varies, and while some patients respond to a particular treatment, other patients do not gain any benefit. Consequently, crucial in cancer therapy is the prediction of a patients response to treatment. Fail",{"id":515,"funder":7,"programme":8,"title":516,"piName":10,"institution":517,"country":340,"year":13,"amount":14,"abstract":518},"cordis-european-research-council-award-101081736","Chemical Engineering of Natural Killer Cells for Cancer Immunotherapy","USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I.","Our immune system evolved to protect our bodies from different invaders and to fight against infections and diseases. Immune cells use sophisticated ways to detect and destroy abnormal cells, while sparing our own cells. Unluckily, cancer cells often develop sneaky tricks enabling them to evade this protecting machinery and to survive and proliferate. Immunotherapy, an emerging concept of treatment, aims to employ the power of immune system to fight cancer by boosting or reeducation of immune ce",{"id":520,"funder":7,"programme":8,"title":521,"piName":10,"institution":522,"country":170,"year":13,"amount":14,"abstract":523},"cordis-european-research-council-award-101069255","Allogeneic Macrophages for Cancer Therapy","TECHNISCHE UNIVERSITAET DRESDEN","Macrophage cell therapy can become an attractive example of a cell therapy, with numerous potential applications, among them cancer therapy. While T-cell based therapies  so successful for the treatment of hematological malignancies!  have yet failed to demonstrate effectiveness in the treatment of solid tumors, macrophages are a key component of the tumor microenvironment (TME), and in principle they are capable of killing solid tumor cells. However, wildtype macrophages commonly respond to the",{"id":525,"funder":7,"programme":8,"title":526,"piName":10,"institution":527,"country":20,"year":13,"amount":14,"abstract":528},"cordis-european-research-council-award-101054365","Chimeric Antigen Receptor (CAR) T Cell Therapy For Solid Tumors","MEDIZINISCHE UNIVERSITAT INNSBRUCK","CAR-T(uning) will assess the technical and commercial feasibility of an improved and broadly applicable chimeric antigen receptor T-cell (CAR-T) approach based on a novel implemented mechanism of action. There is an urgent need for more effective treatment strategies against cancer, which remains the leading cause of death worldwide. Immuno-oncology regimens such as, immune checkpoint blockade therapy (ICT) and CAR-T therapy emerged as powerful tools in cancer treatment, however, in the majority",{"id":530,"funder":7,"programme":8,"title":531,"piName":10,"institution":532,"country":170,"year":13,"amount":14,"abstract":533},"cordis-european-research-council-award-101069245","Minimally invasive endoscopes for neuronal activity monImaging-assisted single-cell specific activity monitoring and optogenetic stimulation of deep brain structures in motile and awaken animal models","LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V.","Severe neuronal disorders such as dementia affect more than 1 billion people globally and account for economic burden far exceeding that of cancer. Our only chance of treating dementia is improving our understanding of how brains function at diverse levels of complexity. This will only be possible through better technologies, which already reflects in synchronised actions worldwide, such as the US Brain Initiative and EU Human Brain project. The origin ERC project LIFEGATE has developed minimall",{"id":535,"funder":7,"programme":8,"title":536,"piName":10,"institution":268,"country":26,"year":13,"amount":14,"abstract":537},"cordis-european-research-council-award-101081529","AI to predict Cancer metastasis using Ultra-Echo-Sono imaging","Cancer metastasis is the leading cause of death within tumor disease and is currently an unmet clinical need. This dramatic clinical evidence requires immediate action in terms of early diagnosis and then pre-emptive therapies, not only for the primary tumor, but especially at the first stages of metastasis formation. Metastasis is the result of a complex mechanism, still under study, which involves the trafficking of biological materials, in particular extracellular vesicles (EVs), from the pri",{"id":539,"funder":7,"programme":8,"title":540,"piName":10,"institution":541,"country":12,"year":13,"amount":14,"abstract":542},"cordis-european-research-council-award-101069163","C- and N-terminal Epitope Conjugate immune Cell Targeted Vaccines","STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM","CNECT-VAX will validate the technical and commercial feasibility of a new cancer vaccine platform that uses nanobodies targeting dendritic cells to co-deliver antigens in vivo. As of 2019, cancer affects over 19 million people worldwide and results in almost 10 million death annually, however, the treatment of patients remains a challenge. Immunotherapy options including dendritic cell (DC) based vaccines have become available, but the clinical efficacy of such treatment remains very modest and ",{"id":544,"funder":7,"programme":8,"title":545,"piName":10,"institution":546,"country":12,"year":13,"amount":14,"abstract":547},"cordis-european-research-council-award-101067731","First-in-class beta-catenin inhibitor as treatment for colorectal cancer","STICHTING VU","With more than 1.9 million new cases and 935,000 related deaths in 2020, colorectal cancer (CRC) is the third most common cancer in men and the second in women. While surgery is the main treatment option for lower grade CRC, patients with unresectable lesions are treated with chemotherapy. Related therapies are associated with severe drawbacks, such as systemic toxicity, low response rate, and unpredictable resistance. Molecular targeted therapies have emerged as a promising strategy to specific",{"id":549,"funder":7,"programme":8,"title":550,"piName":10,"institution":551,"country":60,"year":13,"amount":14,"abstract":552},"cordis-european-research-council-award-101082096","Transforming bone cancer therapy with composite biomaterials encapsulating plasma-generated RONS","UNIVERSITAT POLITECNICA DE CATALUNYA","Improving the survival of patients with osteosarcoma has long proved challenging. Osteosarcoma is a rare bone cancer (less than 0.2% of all cancers). However, it affects mainly children and young adolescents.  The standard therapy for osteosarcoma consists in the surgeon removing the entire tumor with negative margins (resection of larger areas of bone than the tumor itself), to ensure that no cancer cells are found at the edge of the tissue removed. This means that in some cases these surgeries",{"id":554,"funder":7,"programme":8,"title":555,"piName":10,"institution":432,"country":32,"year":13,"amount":14,"abstract":556},"cordis-european-research-council-award-101069334","Development and commercialization of a kit for profiling enzyme activity in liquid biopsies","Ubiquitination is a post-translational modification (PTM) that is critical for numerous biological processes, including cell cycle, autoimmunity, immune responses, and cancer. This has instigated vast interest in targeting the ubiquitin machinery, and in elucidating ubiquitin-dependent events in pathologies. However, a key constraint is the lack of high-throughput methodologies for monitoring ubiquitination in clinical samples. Current tools mostly provide a qualitative sense of ubiquitin substr",{"id":558,"funder":7,"programme":8,"title":559,"piName":10,"institution":139,"country":32,"year":13,"amount":14,"abstract":560},"cordis-european-research-council-award-101061967","Remotely actuated re-shaped nanocarriers for tumour targeting","Current nanometric drug delivery systems have enormous potential to shift clinical practice in diseases that require targeted or site-specific therapy. New tools to fabricating multi-functional drug delivery systems can potentiate drug-carrier activity and offer the necessary shift from inert carriers to active drug carriers that can maximize drug activity in the desired tissue.  This is particularly crucial in cancer, where chemotherapy drugs have broad spectrum non-specific activities. Based o",{"id":562,"funder":7,"programme":8,"title":563,"piName":10,"institution":564,"country":12,"year":13,"amount":14,"abstract":565},"cordis-european-research-council-award-101081881","Valorising magnetometry in cells","ACADEMISCH ZIEKENHUIS GRONINGEN","Magnetic resonance spectroscopy (NMR or ESR) and magnetic resonance imaging (MRI) are widely used. However, magnetic resonance signals are low in energy and thus difficult to detect.  These techniques are expensive and  typically only offer millimeter down to micrometer resolution. Diamond magnetometry potentially offers a solution. The technique is based on a quantum effect and allows even the detection of single electron spins. While the technique is already used for a few years in physics, du",{"id":567,"funder":7,"programme":8,"title":568,"piName":10,"institution":31,"country":32,"year":13,"amount":14,"abstract":569},"cordis-european-research-council-award-101069379","Diagnostics of aberrant cancer glycosylation signatures","Cancer is a leading cause of death worldwide and novel diagnostic and therapeutic approaches are much needed. All living cells are covered with a dense layer of sugar-coat that is altered in cancer. One of the hallmarks of cancer is the expression of aberrant cell surface glycosylation patterns compared to normal cells. Current antibody-based assays against cancer glycans are commonly utilized to monitor clinical response to therapy, however none is useful for early detection or diagnosis due to",{"id":571,"funder":7,"programme":8,"title":572,"piName":10,"institution":432,"country":32,"year":13,"amount":14,"abstract":573},"cordis-european-research-council-award-101060296","Pre-commercialization of circadian clock-drug interactions screening tool for therapeutic applications","Circadian clocks carry an immense importance to human health, as clock disruption is related to various malignancies from sleep disorders through diabetes to cancer. Furthermore, many drug targets are influenced by circadian clocks. In order to maximize drugs efficacy while minimizing side effects, it is necessary to consider the drugs time-of-administration, also known as chronotherapy. These revelations are critical for drug administration and development. However, their practical implementati",{"id":575,"funder":7,"programme":8,"title":576,"piName":10,"institution":577,"country":12,"year":13,"amount":14,"abstract":578},"cordis-european-research-council-award-101100873","Super-resolution microscopy for immune checkpoint inhibitors diagnostics","TECHNISCHE UNIVERSITEIT EINDHOVEN","In the last decade, super-resolution microscopy techniques have emerged as powerful quantitative tools for biology. They have capabilities to visualize single molecules at the nanoscale opening the door to study biological processes at a level not accessible before. In the ERC StG NANOSTORM we showed the potential of these techniques providing new fundamental knowledge on the mechanism and design of new targeted therapies. However, some of the methods we developed have the potential to be transl",{"id":580,"funder":7,"programme":8,"title":581,"piName":10,"institution":582,"country":296,"year":13,"amount":14,"abstract":583},"cordis-european-research-council-award-101069289","A combined diagnostic and targeted gene therapy platform for brain tumor relapse","UPPSALA UNIVERSITET","Emergence of therapy resistance is a major cause of death following conventional chemotherapy and radiation for children and adults with malignant brain tumors. It is imperative to find novel options to target therapy-resistant brain tumor populations to save lives. We propose a novel platform providing a prognostic tool and a suicide gene therapy tool using engineered viruses. It involves targeting freshly biopsied cells from brain tumor patients with our strategy in combination with standard t",{"id":585,"funder":7,"programme":8,"title":586,"piName":10,"institution":31,"country":32,"year":13,"amount":14,"abstract":587},"cordis-european-research-council-award-101101033","Targeted Microarrays for 5-hydroxymethylcytosine-based Diagnosis of Hematological Malignancies","5-hydroxymethylcytosine (5hmC) is an oxidized form of 5-methylcytosine (5mC). It is the first step of reversing DNA methylation and an important indicator of dynamic epigenetic changes in genomic DNA. One characteristic of cancerous transformations is dramatic modulation of the epigenomic landscape. Consequently, changes in the distribution of 5hmC have been shown to correlate with a broad range of cancers and is potentially a powerful disease biomarker. Nevertheless, existing methods for mappin",{"id":589,"funder":7,"programme":8,"title":590,"piName":10,"institution":259,"country":79,"year":13,"amount":14,"abstract":591},"cordis-european-research-council-award-101069405","Non-invasive follow-up of urinary tract cancers","Bladder cancer is the most common malignancy of the urinary tract with 573,000 new cases and 213,000 deaths in 2020 worldwide and affecting more men than women in a 4:1 ratio. Bladder cancer has the highest lifetime treatment costs per patient of all cancers, which is mainly attributed to the intensive follow-up procedures of patients after diagnostics and surgery. Follow-up is made recurring to extremely invasive and low-patient compliant tests. ENSURE aims to validate the technological and bus",{"id":593,"funder":7,"programme":8,"title":594,"piName":10,"institution":595,"country":170,"year":13,"amount":14,"abstract":596},"cordis-european-research-council-award-101069235","Generation and validation of a panel of EMT reporter cell lines from solid tumors","MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)","Cancer is a very heterogeneous disease and its subtypes display great variability in their response to treatment. The high failure rate of anticancer drug discovery consumes billions of dollars annually, contributing to the high cost of those few drugs that are eventually approved. One of the problems lies in inaccurate and oversimplified cell line models for studying human tumors. Yet, a method to incorporate tumour subtype contribution in response to drugs is lacking. To improve experimental o",{"id":598,"funder":7,"programme":8,"title":599,"piName":10,"institution":600,"country":170,"year":13,"amount":14,"abstract":601},"cordis-european-research-council-award-101100794","Decoding the Combinatorial Epigenetic Information of the Mammalian Genome with Engineered DNA Duplex Readers","TECHNISCHE UNIVERSITAT DORTMUND","In mammalian genomes, epigenetic modifications of the nucleobase cytosine occur in both strands of the DNA duplex in the sequence CpG, and they are central regulators of gene expression as well as important cancer biomarkers. However, current analytical techniques cannot reveal the combination in that these modifications occur in the two strands of a DNA duplex. The resulting inability to create genomic maps of these CpG duplex modifcations represents a major roadblock for future developments in",{"id":603,"funder":7,"programme":8,"title":604,"piName":10,"institution":605,"country":12,"year":13,"amount":14,"abstract":606},"cordis-european-research-council-award-101081921","Rescue Pacing for Congenital Complete Heart Block","STICHTING AMSTERDAM UMC","Congenital heart block is the most commonly observed type of foetal bradycardia, occurring in one in 15.000 live births. A significant subset of foetuses develops towards congenital complete heart block (CCHB), i.e., complete failure of the electrical excitation wavefront to be conducted over the atrioventricular (AV) node. CCHB is the most severe and life-threatening cardiac arrhythmia in utero. Current medicinal treatments cannot significantly alter the cause of CCHB and therapeutic attempts a",{"id":608,"funder":7,"programme":8,"title":609,"piName":10,"institution":605,"country":12,"year":13,"amount":14,"abstract":610},"cordis-european-research-council-award-101081970","Novel T cell therapies against lymphocytic leukaemia","Chronic lymphocytic leukaemia (CLL) is the most common type of leukaemia globally and can rarely be cured. Despite recent advances, the efficacy of promising autologous T cell-based therapies, such as CAR-T technology and bi-\u002Ftri-specific antibodies, has been disappointing. This stems from a T cell dysfunction in this disease setting: altered T cell skewing, impaired metabolic plasticity, and disrupted T-cell functioning.Prof. Arnon Kater's group studies alternative activation pathways to overco",{"id":612,"funder":7,"programme":8,"title":613,"piName":10,"institution":614,"country":60,"year":13,"amount":14,"abstract":615},"cordis-european-research-council-award-101069268","Development of a photoelectrochemical device for Ammonia production","Fundacion IMDEA Energia","The growing world population is pressing on an increasing global food and energy demand, and simultaneously contributing to an unceasing rise in carbon dioxide emissions. In this context, finding inexpensive and fossil-free pathways to supply energy and food has become one of the most critical challenges of this century. On this scenario, ammonia (NH3) is envisaged as a zero-carbon fertiliser, fuel and energy store, with a potential key role in the transition towards a low-carbon economy. DEMONI",{"id":617,"funder":7,"programme":8,"title":618,"piName":10,"institution":619,"country":170,"year":13,"amount":14,"abstract":620},"cordis-european-research-council-award-101081905","Deep Brain Neuromodulation using Temporal Interference Magnetic Stimulation","CHARITE - UNIVERSITAETSMEDIZIN BERLIN","Five out of ten diseases leading to long term-disability are related to the brain, including stroke, depression or dementia. Despite tremendous progress in neurotechnology, there is still no effective treatment option available for many brain-related disorders. A very promising approach to treat brain disorders uses transcranial electric or magnetic stimulation (TES\u002FTMS) to directly influence brain activity related to specific symptoms. However, these methods are limited in their spatial resolut",{"id":622,"funder":7,"programme":8,"title":623,"piName":10,"institution":221,"country":170,"year":13,"amount":14,"abstract":624},"cordis-european-research-council-award-101069192","From reconstructions of neuronal circuits to anatomically realistic artificial neural networks","Artificial neural networks (ANNs) have found applications in a wide variety of real-world problems. Despite this tremendous success, artificial intelligence systems still face major challenges due to their reliance on extensive training and large datasets. Recent reports indicate that the architecture of ANNs could be a prime target for reducing their training and data requirements.We hypothesize that such architectural features can be identified from neuronal networks in the brain, which have e",{"id":626,"funder":7,"programme":8,"title":627,"piName":10,"institution":628,"country":60,"year":13,"amount":14,"abstract":629},"cordis-european-research-council-award-101069239","Scanning probe microscopy in high vectorial magnetic fields: New device for imaging quantum materials","UNIVERSIDAD AUTONOMA DE MADRID","The invention of the scanning tunneling microscope (STM) and of other similar devices was a revolution for research at atomic scale. Many companies offer microscopes which can be used to study materials at atomic scale as a function of temperature or magnetic field. However, unlike temperature, the magnetic field is a vector quantity. The direction of the magnetic field vector is as important as its magnitude when it comes to study properties of materials at atomic scale. The only solution avail",{"id":631,"funder":7,"programme":8,"title":632,"piName":10,"institution":633,"country":85,"year":13,"amount":14,"abstract":634},"cordis-european-research-council-award-101069190","Molecular Visualization of High Performance Computing Simulations with VTX","CONSERVATOIRE NATIONAL DES ARTS ET METIERS","Molecular Dynamics Simulations (MD) are widely used in molecular and structural biology and drug discovery to study the structure, properties and dynamics of small and macromolecules. The size of the simulated systems (up to a billion atoms) and the length of the simulations (from microseconds in 2010 to milliseconds in 2021 in million atom scenes) have dramatically increased following the recent advances in computing hardware (GPU clusters) and storage. Additionally, with the recent advances in",{"id":636,"funder":7,"programme":8,"title":637,"piName":10,"institution":638,"country":170,"year":13,"amount":14,"abstract":639},"cordis-european-research-council-award-101069470","Reading DNA in real time for medical applications","UNIVERSITY OF HAMBURG","The aim of this project is to use an ultra-fast, high throughput method for analysing DNA single molecules for liquid biopsy and other biomedical applications. The proposed methodology, Laser-Assisted DNA Optical Mapping (LADOM), allows retrieving the barcode of single molecules of DNA in real time, as they flow through a nanochannel in a fluidic device. It combines a cheap device fabrication, flexible DNA labelling (customizable for different applications), microscope- and camera-free set up, a",{"id":641,"funder":7,"programme":8,"title":642,"piName":10,"institution":234,"country":32,"year":13,"amount":14,"abstract":643},"cordis-european-research-council-award-101100574","MAGNIFICO-Pre-commercialization of multifunctional targeted MRI-contrast enhancing agents for brain research","Magnetic Resonance Imaging (MRI) is a non-damaging and non-invasive imaging modality, with the abilities to effortlessly image the entire brain at any depth. However, MRI provides images with low contrast and very poor resolution, and these are but an indirect description of features in the tissue (e.g., cells) because MRI images water protons. These aspects limit the use of MRI in pre-clinical research settings (e.g., biomedical research) to study brain diseases. Resultantly, pharmaceutical and",{"id":645,"funder":7,"programme":8,"title":646,"piName":10,"institution":647,"country":170,"year":13,"amount":14,"abstract":648},"cordis-european-research-council-award-101069310","Atomic-layer additive manufacturing for solar cells","FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG","The ALAMS project will provide the first application of atomic-layer additive manufacturing (ALAM), namely for the prototyping of solar cells in large arrays of microdevices. The ALAM concept combines the principles of additive manufacturing (3D printing) with the atomic resolution achieved by the thin coating technique atomic layer deposition (ALD). In ALD, atomic-level control is achieved by judiciously designing the surface reaction chemistry of molecular precursors at near-room temperature f",{"id":650,"funder":7,"programme":8,"title":651,"piName":10,"institution":306,"country":60,"year":13,"amount":14,"abstract":652},"cordis-european-research-council-award-101062041","SAFE-ON Technology for Smart Antimicrobial Coatings","Infectious diseases are a rapidly growing threat to humanity. For instance, the current COVID-19 pandemic, caused by the virus SARS-CoV-2, has already killed over 4.5 million people since 2019 and is taking a devastating socioeconomic toll around the world. Similarly, nosocomial infections are among the major causes of death and increased morbidity, causing thousands of deaths every year in Europe. Recently, the use of antimicrobial coatings has garnered increasing interest as a simple prophylac",{"id":654,"funder":7,"programme":8,"title":655,"piName":10,"institution":656,"country":490,"year":13,"amount":14,"abstract":657},"cordis-european-research-council-award-101081756","Thermostable vaccines to enable global immunization","HELSINGIN YLIOPISTO","With GLOBEVAC we present a novel solution to make vaccines thermostable, enabling global immunization by avoiding the need for cold chain logistics.  Vaccines are one of the most successful public health interventions to reduce the morbidity and mortality of infectious diseases. To ensure the safety and effectiveness of a vaccine, the production and distribution of almost all vaccines require what is called a cold chain, where the vaccine is continuously kept below certain threshold temperatures",{"id":659,"funder":7,"programme":8,"title":660,"piName":10,"institution":661,"country":170,"year":13,"amount":14,"abstract":662},"cordis-european-research-council-award-101082087","Up-cycling plastic waste for distributed passive cooling applications","UNIVERSITAT BAYREUTH","CoolChips addresses two grant challenges of our modern society: 1) Global warming requires new technologies to mitigate the ever-accelerating consequences of climate change. Passive daytime cooling is such an emerging technology that requires intricate photonic engineering of materials. 2) Plastic waste is evolving as an increasing challenge to keep our environment pollution-free. We, therefore, will investigate an up-cycling strategy to put used food-packaging polymers to an even better use mit",{"id":664,"funder":7,"programme":8,"title":665,"piName":10,"institution":666,"country":170,"year":13,"amount":14,"abstract":667},"cordis-european-research-council-award-101081888","Metaraminol Demonstration Plant as Commercialisation Blueprint for Sustainable Production of Pharmaceuticals using Enzyme Cascades","FORSCHUNGSZENTRUM JULICH GMBH","The development of more environmentally friendly synthesis methods is urgently needed if humanity wants to maintain an environment worth living in. The establishment of more biocatalytic steps in chemical synthesis is a possible solution, as enzymes and whole cells offer sustainable advantages such as biodegradability, toxicity, high selectivity and much more.Amino alcohols and 2-hydroxy ketones are valuable compounds with various applications in the chemical and pharmaceutical industry with mar",{"id":669,"funder":7,"programme":8,"title":670,"piName":10,"institution":671,"country":12,"year":13,"amount":14,"abstract":672},"cordis-european-research-council-award-101068452","detailed 3D Building models Automatically Generated for very large areas","TECHNISCHE UNIVERSITEIT DELFT","In the ERC project Urban Modelling in higher dimensions (UMnD) we developed a solution for detailed 3D Building models Automatically Generated for very large areas (3DBAG). This prototype was applied to generate detailed 3D models for all 10 million buildings in The Netherlands. Such a digital twin of built objects provides a valuable data source and simulation basis for professionals working in planning, design, construction, energy, real estate, as well as for environmental impact studies on n",{"id":674,"funder":7,"programme":8,"title":675,"piName":10,"institution":676,"country":677,"year":13,"amount":14,"abstract":678},"cordis-european-research-council-award-101069222","Early warning systeM for soil dEgRadation: a statistical physics Approach to cLimate change aDaptation","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","IE","Climate change is an urgent challenge and impacts ecosystems, society and economic activities. Here we focus on the problem of loss of fertile soil (soil degradation), a process that is induced and accelerated by extreme weather and climate change and affects, among other sectors, agriculture, land use planning and food security. Current tools to monitor soil health for commercial purposes or policymaking are either limited in scale due to high cost, or insufficiently accurate due to the lack of",{"id":680,"funder":7,"programme":8,"title":681,"piName":10,"institution":676,"country":677,"year":13,"amount":14,"abstract":682},"cordis-european-research-council-award-101069382","Towards a gene therapy for age-related macular degeneration (AMD)","While the blood neural barriers represent significant hurdles for the development of gene therapies for neurological and ophthalmological conditions it is now becoming clear that many of these conditions actually present with disrupted barrier integrity as the driving force of the pathology. Included in these diseases is age related macular degeneration (AMD), in which we have shown that the blood retina barrier (BRB) is sub-clinically disrupted and is a key driving force for disease progression",{"id":684,"funder":7,"programme":8,"title":685,"piName":10,"institution":686,"country":85,"year":13,"amount":14,"abstract":687},"cordis-european-research-council-award-101062467","Development of an instrumented hammer to assess the stability of hip implant during surgery: assessment of the commercial feasibility","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","Total hip replacement is widely used by orthopedic surgeons, with more than one million procedures per year worldwide. Failures still occur because of a bad implant primary stability or to the occurrence of fractures, inducing pain and increased costs for the healthcare system. Although implant primary stability is the main determinant of the implant success, it remains difficult to be assessed in clinical practice. Impactor is based on results obtained in the ERC CoG project BoneImplant and aim",{"id":689,"funder":7,"programme":8,"title":690,"piName":10,"institution":686,"country":85,"year":13,"amount":14,"abstract":691},"cordis-european-research-council-award-101082079","Quartz On-chip for Virus Detection","The global-scale pandemic crisis of COVID-19 requires precise and immediate technological solutions for virological and serologicaldiagnosis tests. These tests must be accurate, rapid, intelligent, and cost-efficient to prevent future rebounds of infections and helpcontrol the pandemic. In this context, the Microelectromechanical Systems (MEMS) industry, especially piezoelectric resonators of allshapes and sizes, is a promising strategy to revolutionize the biological detection market. Ultrahigh",{"id":693,"funder":7,"programme":8,"title":694,"piName":10,"institution":686,"country":85,"year":13,"amount":14,"abstract":695},"cordis-european-research-council-award-101069469","Membrane Electrode Assembly for the High Pressure Electrochemical Conversion of CO2 to C2H4","The electrochemical conversion of CO2 to chemical fuels is a promising technology for recycling CO2 and closing the carbon cycle. Amon the different products of the electrochemical reduction of CO2, multicarbon (C2+) product are more desirable because of their high energy density and high market price. Among them, ethylene is widely used for the production of raw materials and has a market price around 1000€\u002Ftons, which suggests relatively low threshold towards profitability. The development of ",{"id":697,"funder":7,"programme":8,"title":698,"piName":10,"institution":699,"country":85,"year":13,"amount":14,"abstract":700},"cordis-european-research-council-award-101069360","Novel Probes for Scanning Probe Microscopy","ECOLE POLYTECHNIQUE","For more than 30 years, the platforms based on scanning probe microscopy (SPM) have contributed enormously in the progress of nanoscience and nanotechnology, becoming a fundamental tool for specialists spanning a wide range of research fields, such as materials science, nanoelectronics or biophysics. The versatility of these multipurpose microscopes is bestowed by the extended variety of probes available in the market, used to interact with the nanoscale. For this proof of concept grant, we will",{"id":702,"funder":7,"programme":8,"title":703,"piName":10,"institution":686,"country":85,"year":13,"amount":14,"abstract":704},"cordis-european-research-council-award-101081838","Virus Inhibition by siRNA Optimized by NMR","The last two years, profoundly marked by the COVID-19 sanitary crisis, have demonstrated the difficulties to answer adequately to the emergence of novel pathogenic viruses. Today, no broad-spectrum antiviral exists similar to antibiotics targeting bacteria. Repositioning of existing molecules had limited success despite intense initial hopes. Vaccines have played a major role in fighting the pandemic and limiting the impact of the virus, however it remains insufficient to end the pandemic, due t",{"id":706,"funder":7,"programme":8,"title":707,"piName":10,"institution":686,"country":85,"year":13,"amount":14,"abstract":708},"cordis-european-research-council-award-101069173","MagMech: Precision magnetic tweezers for the mechanobiology of cells and tissues.","The mechanobiology of cells and tissues plays an essential role in physiology and diseases. This emerging field at the frontier between physics, engineering and biology, heavily relies on precise and  versatile devices to apply and measure mechanical forces within and around cells and tissues. However the current commercial landscape is restricted to few systems that are limited to a small range of forces and poorly compatible with large tissues and embryos. In the FORCASTER ERC Consolidator pro",{"id":710,"funder":7,"programme":8,"title":711,"piName":10,"institution":686,"country":85,"year":13,"amount":14,"abstract":712},"cordis-european-research-council-award-101069377","Regenerative ICOs: Tokenizing Debt and Dividends","The economic incentive structures of an organisation strongly influences their governance models & power distribution, sometimes to the extent that attempts at decentralising governance fail, if they are built on centralising economic incentives. Traditional forms of equity investing offer uncapped returns to shareholders that create strong incentives for profit maximisation and centralisation of power. Initial Coin Offerings (ICOs) on the blockchain were designed to allow organisations to raise",{"id":714,"funder":7,"programme":8,"title":715,"piName":10,"institution":686,"country":85,"year":13,"amount":14,"abstract":716},"cordis-european-research-council-award-101101026","Multimodal quantitative phase microscopy","Quantitative phase microscopies (QPMs) experienced a strong gain of interest this last decade, expecially for bioimaging applications. Mapping the phase of a light beam enables biologists to enhance the contrast of live cells in culture without invasive fluorescent labelling. It also enables the unprecedented capability of QPMs to accurately measure the biomass of live cells observed by optical microscopy. This capability, out of reach using fluorescence microscopy, yields an accurate control of",{"id":718,"funder":7,"programme":8,"title":719,"piName":10,"institution":686,"country":85,"year":13,"amount":14,"abstract":720},"cordis-european-research-council-award-101081821","Haptic sensing skin for biomedical applications with soft magnetorheological elastomers","Sensorial and tacSensorial and tactile information represent the base of all surgical procedures in medicine. The vision sense has been and continues to be developed extensively by use of micro-cameras, MRI, X-rays and many others. Nonetheless, in many cases, the vision is not enough. The touch sense is necessary to identify the stiffness of the underlying organ or tissue and press more or less to perform a cut, remove a tumor or even move a catheter inside a curved vain. This stiffness is trans",{"id":722,"funder":7,"programme":8,"title":723,"piName":10,"institution":686,"country":85,"year":13,"amount":14,"abstract":724},"cordis-european-research-council-award-101069301","A companion magnetic sensor for in operando detection of magnetic biosynthesis in cancer and neurodegenerative models","Iron is essential for all life forms as it is a core component of many vital metabolic processes. In humans, iron homeostasis is controlled by sophisticated processes regulating its storage, transport, and export. More recently, the role of iron in diseases also emerged with ferroptosis being a form of cell death that is implicated for instance in the onset and progression of cancer or neurodegenerative disorders. Here, we focus on another intriguing type of iron in the body: the magnetic iron, ",{"id":726,"funder":7,"programme":8,"title":727,"piName":10,"institution":728,"country":85,"year":13,"amount":14,"abstract":729},"cordis-european-research-council-award-101069446","Custom Cryptographic Solutions with Formal Security Guarantees","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","Modern web applications routinely rely on standardized cryptographic protocols and algorithms to protect sensitive user data. Furthermore, with the advent of blockchains, the imminence of quantum computers, and widespread concerns about privacy in an era of surveillance and machine learning algorithms, enterprises are increasingly turning to sophisticated non-standard cryptographic solutions customized for  specific usage scenarios. Unfortunately, cryptographic design and implementation is notor",{"id":731,"funder":7,"programme":8,"title":732,"piName":10,"institution":733,"country":12,"year":13,"amount":14,"abstract":734},"cordis-european-research-council-award-101100999","CRISPR Point-of-Care Diagnostics","WAGENINGEN UNIVERSITY","Monitoring of human health and the prevention\u002Ftreatment of (infectious) diseases strongly depend on accurate and efficient detection, identification and tracking of pathogens or biomarkers. Key features of such a diagnostic tool that enable this are speed, accuracy and availability at the point-of-care. Current molecular diagnostic solutions do not meet these requirements due to the fact that they often need to be performed in a centralized fashion. However, the incredible advances in CRISPR-Cas",{"id":736,"funder":7,"programme":8,"title":737,"piName":10,"institution":738,"country":60,"year":13,"amount":14,"abstract":739},"cordis-european-research-council-award-101100978","Blocking BAFF signaling to treat Proliferative Kidney Disease (PKD) in trout","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","PKDControl is aimed at validating the use of a recombinant protein to reduce the pathology and mortality produced by proliferative kidney disease (PKD) in salmonids. PKD is caused by the myxozoan parasite Tetracapsuloides bryosalmonae that affects both cultured and wild salmonids in North America and Europe. It can eventually lead to mortalities of up to 90%, generating great economic loses every year to the aquaculture industry. This problem may be aggravated by global warming since the inciden",{"id":741,"funder":7,"programme":8,"title":742,"piName":10,"institution":738,"country":60,"year":13,"amount":14,"abstract":743},"cordis-european-research-council-award-101069337","Affordable and sustainable self-powered GLUCOSE sensing system for a global FAIR diabetes management","FAIRGLUCOSE proposes a low cost, sustainable and self-powered standalone glucose sensing system that relies on the well-known oxidation process of glucose coming from finger prick blood and transfers it to a voltage readout through an innovative and extremely simple strategy. In this way, a measurement that typically requires a potentiostat with a microcontroller and a battery is performed here with a minimalistic and battery-less circuit that fits within the footprint of a commercial glucose st",{"id":745,"funder":7,"programme":8,"title":746,"piName":10,"institution":738,"country":60,"year":13,"amount":14,"abstract":747},"cordis-european-research-council-award-101069298","Open Geometry PET, with 150ps TOF Resolution, for Real Time Molecular Imaging","Open-IMAGING will develop an innovative Open Imaging System, highly flexible and adaptable to the organ to be examined. The system of the Proof of Concept will consist of two large paddle detectors built with the novel PET (Positron Emission Tomography) technology developed in 4D-PET ERC-ADG. Outstanding (\u003C150ps) Coincidence Time Resolution and placing the detectors closer to the Field of View (FOV) will dramatically increase the sensitivity, allowing high resolution and high contrast images, at",{"id":749,"funder":7,"programme":8,"title":750,"piName":10,"institution":738,"country":60,"year":13,"amount":14,"abstract":751},"cordis-european-research-council-award-101081998","Scalable Method for Synthesis of multifunctional colloidal INKs for Superconductors","Global warming is one of the main challenges that society is currently facing. It involves a major change of the energy paradigm to drastically reduce CO2 emissions. High Temperature Superconductivity presents a huge interest worldwide for its opportunities for cleantech energy as superconductors allow energy harvesting and transport electric power with minimal losses. Superconducting nanocomposites in the form of coated conductors (CC) are specially interesting as generators operating at high m",{"id":753,"funder":7,"programme":8,"title":754,"piName":10,"institution":738,"country":60,"year":13,"amount":14,"abstract":755},"cordis-european-research-council-award-101069234","Cellulose Based Photonic Materials","Improper recycling of plastics leads to their degradation in the environment, resulting in smaller pieces of plastics that are harmful for the life on the planet. Microplastics are also intentionally included in many products as whitening agents, to produce white appearance in many personal care products and contribute to the microplastic pollution. In this proposal, we will provide the industry with viable alternatives to substitute current opacifying agents that follow European regulations. In",{"id":757,"funder":7,"programme":8,"title":758,"piName":10,"institution":738,"country":60,"year":13,"amount":14,"abstract":759},"cordis-european-research-council-award-101069348","INorganic Photochemical PATTerning","Light activation finds a widely spread application to produce photochemically solid organic resins at low irradiation intensity from liquid organic precursors. The main advantages of this process are that it can be activated locally, by focusing a light beam, remotely, and switched on\u002Foff easily, in a safe and convenient irradiation regime. For these features, light-activated polymerization is used for patterning organic structures in fields of high technological, economic and social impact such",{"id":761,"funder":7,"programme":8,"title":762,"piName":10,"institution":763,"country":26,"year":13,"amount":14,"abstract":764},"cordis-european-research-council-award-101069392","Systemic delivery of oncolytic herpes simplex viruses retargeted to cancer-specific receptors. Virus optimization and business planning.","FONDAZIONE POLICLINICO SANT'ORSOLA ONLUS","Solid tumors, in particular metastatic ones, represent unmet clinical needs and the second cause of death worldwide. Oncolytic viruses (OVs) kill tumors and spare normal cells. They are a distinct class of novel anti-cancer agents, frequently administered by intratumoral injection. A Holy Grail in the innovation of OVs is the possibility to administer them by systemic, e.g. intravenous injection, so that in the human body OVs search for metastases and scavenge them. The systemic delivery of OVs ",{"id":766,"funder":7,"programme":8,"title":767,"piName":10,"institution":768,"country":85,"year":13,"amount":14,"abstract":769},"cordis-european-research-council-award-101062030","Lectibodies to Eliminate Tumours","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","Antibody-mediated delivery of therapeutic compounds to tumor cells for the treatment of cancer is a rapidly growing multibillion-euro market. One class of tumor markers, the glycosphingolipids (GSLs), are only rarely addressed in this context, due to the difficulty of obtaining antibodies against them. In this proof-of-concept program, we will develop a novel class of products  lectibodies  for the delivery of therapeutic compounds to tumor-specific GSLs. Our lectibodies are based on a naturally",{"id":771,"funder":7,"programme":8,"title":772,"piName":10,"institution":768,"country":85,"year":13,"amount":14,"abstract":773},"cordis-european-research-council-award-101069276","Therapeutic discovery for cholangiocellular carcinoma","Cholangiocarcinoma (CCA) is one of the deadliest cancers comprising a heterogeneous cluster of malignancies that are distinct to hepatocellular carcinoma (HCC) and that can emerge at any point in the biliary tree. While not very common, CCA is responsible for 2% of cancer-related deaths worldwide annually and rising. The incidence in European countries is increasing rapidly ranging from 1 to more than 4 cases\u002F100,000. CCA is mostly diagnosed very late resulting in aggressive disease progression,",{"id":775,"funder":7,"programme":8,"title":776,"piName":10,"institution":777,"country":26,"year":13,"amount":14,"abstract":778},"cordis-european-research-council-award-101069187","Integrated photonic circuit fabrication by femtosecond laser writing for quantum information","CONSIGLIO NAZIONALE DELLE RICERCHE","Quantum technologies promise to revolutionize the way we acquire, manipulate and communicate information. Photons are key players in quantum technologies with a transversal role in all applications. In particular, integrated photonics is the only viable approach to scale up quantum photonics to the level of real-world applications. In this context, many materials and fabrication tecnologies are being explored. Among them femtosecond laser writing of photonic circuits in transparent glasses is a ",{"id":780,"funder":7,"programme":8,"title":781,"piName":10,"institution":777,"country":26,"year":13,"amount":14,"abstract":782},"cordis-european-research-council-award-101069262","All-around encapsulated Xene membranes for integration in transistors","Silicon is the key building block of transistors, the workhorse of modern electronics. Since the early 2000s, scaling down the transistors size according to Moores Law to increase clock speed, decrease energy requirements and enhance compactness has been progressively more challenging than it had been for the previous 40 years. Reducing silicon at the two-dimensional level is a technological vision to achieve the ultimate shrinking of high-performance electronic devices and gain enough mechanica",{"id":784,"funder":7,"programme":8,"title":785,"piName":10,"institution":777,"country":26,"year":13,"amount":14,"abstract":786},"cordis-european-research-council-award-101066434","Microgel technology for preservation of cultural heritage","This PoC proposal is dedicated to the development of a new soft matter technology for paper preservation. Building on the recent ERC grant of the PI, MIMIC, that was mainly a theoretical and numerical effort on “Modelling microgels” in close synergy with experiments, MICROTECH proposes to exploit this fascinating class of soft colloids in a new application for cultural heritage. Microgels are colloidal-scale polymer networks, whose properties intrinsically depend on those of the constituent poly",{"id":788,"funder":7,"programme":8,"title":789,"piName":10,"institution":777,"country":26,"year":13,"amount":14,"abstract":790},"cordis-european-research-council-award-101081567","HyperSpectral Terahertz neAR-field nanoscope exploiting miniaturized frequency-combs","‘STAR’ aims to increase the technology readiness level of the state-of-the-art graphene-integrated, miniaturized frequency comb (FC) quantum cascade laser (QCL), operating at terahertz (THz) frequencies, devised under the ERC consolidator grant ‘SPRINT’, and develop a detector-less sensing\u002Fimaging demonstrator apt to the translation of this technology to industrial end-users. The focus is on providing a compact, low-cost, hyperspectral, nanoscale imaging system, which creates amplitude- and phas",{"id":792,"funder":7,"programme":8,"title":793,"piName":10,"institution":794,"country":170,"year":13,"amount":14,"abstract":795},"cordis-european-research-council-award-101069369","Methyltransferase inhibitors for treatment of COVID19","TECHNISCHE UNIVERSITAET MUENCHEN","Our IP secured drug DZNep is effective in treating SARS-CoV-2 infections in preclinical disease models and uniquely suppresses virus growth, triggers the innate immunity and facilitates tissue regeneration. The ERC-PoC will enable the transition from preclinical to clinical research.",{"id":797,"funder":7,"programme":8,"title":798,"piName":10,"institution":799,"country":274,"year":13,"amount":14,"abstract":800},"cordis-european-research-council-award-101062180","Advanced Software Tools for JavaScript Developers","AARHUS UNIVERSITET","Modern web-based software uses the JavaScript programming language together with the Node.js framework and extensively rely on freely available third-party software libraries that provide common functionality. These libraries are continuously improved, and new versions are released frequently. This massive reuse of libraries is essential to the productivity of software developers, however, the dependence on other people's libraries opens the door to security vulnerabilities and programming error",{"id":802,"funder":7,"programme":8,"title":803,"piName":10,"institution":804,"country":26,"year":13,"amount":14,"abstract":805},"cordis-european-research-council-award-101069326","Preclinical validation and market analysis of a microMESH implant for brain cancer eradication","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","Despite tremendous progress in the treatment of several malignancies, glioblastoma continues to be the less curable form of any cancer with an overall average survival of 20 months from diagnosis. In this PoC, an interdisciplinary team of engineers, biotechnologists and technology-transfer experts will work to prove that a ground-breaking drug delivery implant – microMESH – can be engineered to deploy intracranially a chemo-immuno-combination therapy to eradicate glioblastoma and minimize its li",{"id":807,"funder":7,"programme":8,"title":808,"piName":10,"institution":804,"country":26,"year":13,"amount":14,"abstract":809},"cordis-european-research-council-award-101069179","Wearable Integrated Soft Haptic Display for Prosthetics","In this ERC Proof of Concept, we want to develop a wearable fluidic force feedback device for upper and lower limb prostheses, composed by soft silicone chambers along with their actuation and control units, to exert pressures in multiple specific stump sites. This solution, named Wearable Integrated Soft Haptic device (WISH), strives to achieve both good modality matching (MM) and somatotopic matching (SM), while keeping non-invasive and practicable. The principle, preliminarily demonstrated on",{"id":811,"funder":7,"programme":8,"title":812,"piName":10,"institution":813,"country":12,"year":13,"amount":14,"abstract":814},"cordis-european-research-council-award-101069218","reGeneRative bone Implant for the treatment of hip dysPlasia","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","GRIP develops a personalised, 3D-printed regenerative bone implant as a treatment for hip instability (hip dysplasia) and its commercialisation strategy. Osteoarthritis (OA) of the hip is a painful and debilitating condition and hip dysplasia is one of the two main causes. The currently most common surgical methods to correct the dysplasia involve the re-alignment of the hip socket (osteotomy) or the insertion of a bone graft to enlarge the socket (shelf arthroplasty). While the osteotomy is inv",{"id":816,"funder":7,"programme":8,"title":817,"piName":10,"institution":818,"country":79,"year":13,"amount":14,"abstract":819},"cordis-european-research-council-award-101069302","BioCHIPS - Biofabricated microfluidcs CHIPS based on self assembling of CNCs to recreate the hierarchical fibrillar structure of human tissues ECM","UNIVERSIDADE DO MINHO","Biochips proposes an innovative bottom-up strategy to directly fabricate cell-laden devices that recreate the unique biophysical cues from the native fibrillar ECMs and allow the design of bioengineered microtissues with arbitrary geometries. The proposed platform combines the concepts of matrix-assisted 3D free-form bioprinting with the controlled self-assembly of colloidal cellulose nanocrystals (CNCs) to fabricate cell-laden constructs embedded within its own fibrillar CNC hydrogel device. Th",{"id":821,"funder":7,"programme":8,"title":822,"piName":10,"institution":671,"country":12,"year":13,"amount":14,"abstract":823},"cordis-european-research-council-award-101081830","All-acoustic Bubble Microrheology for rapid screening of formulations","ABuMic aims to address a critical challenge of our society: the transition of formulated products to a safer and more sustainable industry. There is increasing pressure on the industry, both from the public opinion and regulatory bodies, for healthier food products and more environmentally friendly paints and coatings. As a result, in the coming years many formulated products will need to be re-formulated. This will come at a huge cost for the industry, because by and large, product development ",{"id":825,"funder":7,"programme":8,"title":826,"piName":10,"institution":804,"country":26,"year":13,"amount":14,"abstract":827},"cordis-european-research-council-award-101081171","Fast & automated droplet tracking tool for microfluidics","Microfluidics technology targets droplet manipulation by confining fluids to manufacture materials for many industrial applications and life sciences. Data analysis obtained by microfluidic experiments remains a bottleneck to this day due to the lack of a reliable interface converting raw observations to informative data fast enough and at low operating costs. Many computer vision tools exist, which permit to infer useful physical information from video data but they typically target specific ph",{"id":829,"funder":7,"programme":8,"title":830,"piName":10,"institution":676,"country":677,"year":13,"amount":14,"abstract":831},"cordis-european-research-council-award-101069183","SHARE IT SOLUTIONS","Building directly on the findings of a key output from the ERC project SHARECITY - the SHARE IT platform - SIS will upgrade the user experience of the platform and widen its user base to include food retailers and local governments, by designing, testing and validating the following solutions:- A consultancy service for FSIs that do not have capacity or capability to use SHARE IT autonomously. Based on findings from earlier trials and testing, this service would include one-to-one tutorials, gro",{"id":833,"funder":7,"programme":8,"title":834,"piName":10,"institution":671,"country":12,"year":13,"amount":14,"abstract":835},"cordis-european-research-council-award-101069343","Nanofluidic chips for reproducible cryo-EM sample preparation with picoliter sample volumes","Cryogenic transmission electron microscopy (cryo-EM) is a technique for high-resolution imaging of radiation-sensitive biological macromolecules under near-native conditions. Cryo-EM sample preparation techniques rely on rapid cooling of an aqueous suspension of biological macromolecules to obtain a thin layer of amorphous ice containing the solute. Problems associated with current implementations are considered a major bottleneck to realizing the full potential of cryo-EM: excessive sample cons",{"id":837,"funder":7,"programme":8,"title":838,"piName":10,"institution":676,"country":677,"year":13,"amount":14,"abstract":839},"cordis-european-research-council-award-101066777","QSM in plaque vulnerability diagnosis – a software tool for early clinical assessment","Stroke is the leading cause of disability and the third leading cause of death in the Western World. Over 50% of strokes occur inasymptomatic patients and therefore better indicators of the disease are required. These acute asymptomatic cerebrovascularevents are due to vulnerable plaque rupture leading to thromboembolic events, stroke, and\u002For sudden death. From our work to-dateas part of ERC Starting grant FibreRemodel, we have found that that most significant contributor to rupture strength of ",{"id":841,"funder":7,"programme":8,"title":842,"piName":10,"institution":43,"country":32,"year":13,"amount":14,"abstract":843},"cordis-european-research-council-award-101063371","A 64Cu(II)-based radiotracer for diagnosing hypoxic conditions in cancer cells","Cancer is a leading cause of morbidity and mortality worldwide, development of new methodologies to early and accurate diagnosis of cancer, should reduce these death rates. Hypoxia is associated with low oxygen levels in the cells, which leads to an increase in tumor aggressiveness, and to resistance to chemotherapy and radiation therapy. Therefore, there is a compelling need to develop a biomarker for detection and imaging of hypoxic cells. Despite on-going efforts to identify and\u002For track hypo",{"id":845,"funder":7,"programme":8,"title":846,"piName":10,"institution":847,"country":85,"year":13,"amount":14,"abstract":848},"cordis-european-research-council-award-101069281","Targeting Epilepsy Ictogenesis Process Through Pannexin-1 Modulation","COLLEGE DE FRANCE","Epilepsy, affecting about 1% of the population, comprises a group of neurological disorders characterized by the periodic occurrence of seizures, which disrupt normal brain function. Despite treatment with current antiepileptic drugs, one third of epileptic patients are pharmacoresistant and most patients suffer from side effects, making it crucial to develop novel therapies. Current drugs indeed target channels and receptors involved in normal brain function, not specific to the disease.Our aca",{"id":850,"funder":7,"programme":8,"title":851,"piName":10,"institution":432,"country":32,"year":13,"amount":14,"abstract":852},"cordis-european-research-council-award-101069100","Precommercializing a Method For Inducing Muscle Fiber Formation For Industrial Meat Production","The global population is expected to reach 9 billion mark by 2050 which will cause an increase of 70% on the global demand for food. However, if the global trends of meat and animal products consumption continue at the current rate, the global mean temperature will rise by over 2C despite the emissions of non-agricultural sectors being drastically decreased. Therefore, a growing need exists to develop more efficient protein production options. During embryonic muscle development, myoblasts proli",{"id":854,"funder":7,"programme":8,"title":855,"piName":10,"institution":856,"country":60,"year":13,"amount":14,"abstract":857},"cordis-european-research-council-award-101082198","Novel engineered cytokines for human therapy","FUNDACIO CENTRE DE REGULACIO GENOMICA","Cytokines are biomolecules of great potential interest for human therapy. They modulate the immune system and play an important role in cancer, inflammation, immune response and tissue regeneration. Despite their great potential, there are only a handful of cytokines approved for therapeutic purposes.  This is because many of them can have adverse side effects as they usually target different cell types, which adds to their low serum half-life, high production costs, or lack of physiological eff",{"id":859,"funder":7,"programme":8,"title":860,"piName":10,"institution":656,"country":490,"year":13,"amount":14,"abstract":861},"cordis-european-research-council-award-101069256","COMMERCIALISATION OF A NOVEL PROTEIN VARIANT WITH NEURORESTORATIVE EFFECTS FOR AMYOTROPHIC LATERAL SCLEROSIS","REGENERA will assess the technical and commercial feasibility of a novel and optimised C-MANF peptide as a superior treatment for amyotrophic lateral sclerosis (ALS). ALS is a fatal neurodegenerative disease affecting 450,000 people worldwide where motoneurons (MNs) selectively degenerate in the brain and spinal cord. ALS is characterised by muscle deterioration that rapidly leads to disability and culminates in death 3-5 years after diagnosis. Unfortunately, there is no cure for ALS and current",{"id":863,"funder":7,"programme":8,"title":864,"piName":10,"institution":432,"country":32,"year":13,"amount":14,"abstract":865},"cordis-european-research-council-award-101100758","Hit-to-Lead Development of potent broad-spectrum coronavirus fusion inhibitors","The Covid-19 pandemic emphasized the urgent need for efficient broad-spectrum antiviral drugs against potential future coronaviruses (CoV) strains that may cause the next COVID pandemic. A critical stage during infection is the fusion of the viral envelope with the host-cell membrane, which depends on the conserved S2 domain of the viral Spike (S) protein. Hence, targeting the S2 domain is a promising approach to achieving pan-CoV inhibition. Since MERS- and SARS- S proteins bind to different ce",{"id":867,"funder":7,"programme":8,"title":868,"piName":10,"institution":804,"country":26,"year":13,"amount":14,"abstract":869},"cordis-european-research-council-award-101069295","Conductive oxide-based dispersions from non-critical raw materials for functional nanoinks","Transparent conductive oxides (TCOs) inks combine high transparency in the visible and high electrical conductivity with the benefits of solution processing for printable electronics. The most promising TCO, Sn:In2O3 (ITO), is currently being replaced on the transparent conductive inks market due to supply risk of ITO. Alternatives range from silver flakes, to copper pastes, or graphene and other carbon based materials. However, the remarkable environmental stability, chemical tunability, and op",{"id":871,"funder":7,"programme":8,"title":872,"piName":10,"institution":873,"country":20,"year":13,"amount":14,"abstract":874},"cordis-european-research-council-award-101069247","Energy storage with bulk liquid redox materials","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","The problem: Electrifying transport and storing electricity from renewable intermittent sources is mandatory for a carbon neutral society. Best in class energy density helped Lithium ion batteries (LIB) to now widespread use, giving a taste of the full promise of electrochemical energy storage (EES). However, they rely on scarce elements with associated major cost and energy input for production. Hence, the required giant scale deployment makes no sense ecologically nor economically. Alternative",{"id":876,"funder":7,"programme":8,"title":877,"piName":10,"institution":686,"country":85,"year":13,"amount":14,"abstract":878},"cordis-european-research-council-award-101069259","High-energy micro-supercapacitors based on low-cost materials","Miniaturized energy storage solutions are key to powering the modern era of connected devices, which is at the heart of Internet of Things (IoT) concept. Microsupercapacitor electrodes with 3D architectures have drawn increasing interest in recent years due to their better energetic performances while maintaining a reduced footprint occupancy. Thin films of pseudocapacitive RuO2 active materials deposited onto highly porous Pt current collectors,  sculptured via the hydrogen bubble templated ele",{"id":880,"funder":7,"programme":8,"title":881,"piName":10,"institution":164,"country":26,"year":13,"amount":14,"abstract":882},"cordis-european-research-council-award-101069172","A Sensor for Autonomous Navigation in Deep Space","The “space revolution” is expected to become the biggest industry in history. During the last decades, space exploration has contributed to the development of various technologies (i.e., GPS, weather predictions, solar cells, reliable power grid, Earth observation services) that feedback into the economy and improve our lives. In 2020, the global space economy was valued at about $ 446.9 B. With the advent of deep-space CubeSats, nanosatellites that disrupted this industry, space agencies are pl",{"id":884,"funder":7,"programme":8,"title":885,"piName":10,"institution":886,"country":490,"year":13,"amount":14,"abstract":887},"cordis-european-research-council-award-101069288","Electroluminescent cooler prototype","AALTO KORKEAKOULUSAATIO SR","Refrigeration is necessary in an ever increasing number of technical applications with significant societal importance. The presently available solutions, however, have several shortcomings especially in applications requiring extremely compact cooling with access to cryogenic temperatures. This project aims to provide the commercial incentive and a proof of concept for an optical cooler based on the thermodynamics of electroluminescence. The targeted cooling system would allow a robust and comp",{"id":889,"funder":7,"programme":8,"title":890,"piName":10,"institution":686,"country":85,"year":13,"amount":14,"abstract":891},"cordis-european-research-council-award-101082254","ELectoral information and analYSis System for the enhancement of democrAcy","ELectoral information and analYSis System for the enhancement of democrAcy.Building on the expertise in electoral analysis developed within the ERC TARICA (Political and Socio-institutional Change in North Africa), the ELYSSA project (ELectoral information and analYSis System for the enhancement of democracy) aims at facilitating access to electoral information by providing different categories of users (NGOs, media, political actors, cooperation institutions) with tools for the analysis of voti",{"id":893,"funder":7,"programme":8,"title":894,"piName":10,"institution":895,"country":79,"year":13,"amount":14,"abstract":896},"cordis-european-research-council-award-101100653","FARE_AUDIT: Fake News Recommendations - an Auditing System of Differential Tracking and Search Engine Results","LABORATORIO DE INSTRUMENTACAO E FISICA EXPERIMENTAL DE PARTICULAS LIP","The spread of disinformation is a serious problem that impacts social structure and threatens democracies worldwide. Citizens increasingly rely on (dis)information available online, either somewhat passively, through social media feeds, or actively, by using search engines and specific websites. In both scenarios, algorithms filter and select displayed information according to the users past preferences. There is a real risk that algorithms might reinforce the users beliefs and create (dis)infor",{"id":898,"funder":7,"programme":8,"title":899,"piName":10,"institution":900,"country":677,"year":13,"amount":14,"abstract":901},"cordis-european-research-council-award-101069264","Delivering a useable method for mapping groups in attitude networks by developing a robust prototype, development community, and exploitation model to maximize the social value of the breakthrough","UNIVERSITY OF LIMERICK","Our ERC project developed a mathematical method to construct bipartite graphs directly from surveys of attitudes and opinions, providing a network representation of opinion-based groups. This approach reveals group structure, locates individuals in the space, allows the application of network methods to analyze their relations, and can detect ideological polarization, even without extremism. Like the invention of a new instrument for observing the physical world (e.g. a telescope), the method gi",{"id":903,"funder":7,"programme":8,"title":904,"piName":10,"institution":905,"country":79,"year":13,"amount":14,"abstract":906},"cordis-european-research-council-award-101101088","Nature-inspired Cryopreservation Systems using Natural Deep Eutectic Systems","UNIVERSIDADE NOVA DE LISBOA","Cell therapies are foreseen as the next generation therapeutics for some of the chronic diseases with highest global economic and social burden. The market for human cell therapies has been estimated to be 8 B€ in 2021 with an expected annual growth rate of 26% until 2028. The key aspect for the success of a cell therapy is the preservation of cells. Currently, cells must be cryopreserved using a cryoprotectant agent (CPA) at -196ºC, in a liquid nitrogen tank. The gold standard CPA is a chemical",{"id":908,"funder":7,"programme":8,"title":909,"piName":10,"institution":910,"country":26,"year":13,"amount":14,"abstract":911},"cordis-european-research-council-award-101069395","TREM2 MICROglia ENGENEering for treating dementiaS (TREM2MICROENGINES)","UNIVERSITA DEGLI STUDI DI PADOVA","The project TREM2MICROENGINES aims at demonstrating that raising and restoring TREM2 expression in the brain of Alzheimer’s disease (AD) and Nasu–Hakola disease (NHD) patients, and in particular in their microglia, would result in therapeutic benefit.AD is a severe neurodegenerative disorder that represents the most frequent form of dementia among the elderly which affects approximately 5.1 million Americans and this number is supposedly tripled by 2050. AD is believed to result from the deposit",{"id":913,"funder":7,"programme":8,"title":914,"piName":10,"institution":234,"country":32,"year":13,"amount":14,"abstract":915},"cordis-european-research-council-award-101069174","A novel support material for 3D bioprinting and post-printing tissue growth: Print and Grow","Three-dimensional (3D) bioprinting holds great promise for tissue engineering, with extrusion bioprinting in suspended hydrogels becoming the leading bioprinting technique in recent years. In this method, living cells are incorporated within bioinks, extruded layer by layer into a granular support material and undergo gelation through diverse cross-linking mechanisms. It offers high fidelity and precise fabrication of complex structures based on the living tissue properties, however the transiti",{"id":917,"funder":7,"programme":8,"title":918,"piName":10,"institution":295,"country":296,"year":13,"amount":14,"abstract":919},"cordis-european-research-council-award-101069456","RNA and Nanotechnology Enable Wider Accessibility to Stem Cell Transplantation","Every year, more than 50 000 patients receive blood stem cell transplantation as a curative treatment for diseases such as leukemia, immune deficiencies, and sickle cell anemia. For a successful transplantation, a matching donor who is willing to donate blood stem cells needs to be found. Worldwide, around 30% patients in need of a transplantation cannot find a suitable donor. Umbilical cord blood (UCB) is an easily obtainable alternative source of blood stem cells, but unfortunately most UCB un",{"id":921,"funder":7,"programme":8,"title":922,"piName":10,"institution":25,"country":26,"year":13,"amount":14,"abstract":923},"cordis-european-research-council-award-101081871","Multimode Fiber Raman Amplifier for Unrepeatered Optical Communications","The project aims at a proof-of-concept demonstration of a novel technology, enabling a substantial extension of the reach of unrepeatered fiber optic communication links. MULTIBRIDGE will permit to cross the ultimate frontier of high-capacity transmission systems, by introducing a new method for the amplification of multiple optical signals, that simultaneously propagate in long-haul, unrepeatered transmission systems based on multimode optical fibers. This will lead to a breakthrough distance i",{"id":925,"funder":7,"programme":8,"title":926,"piName":10,"institution":676,"country":677,"year":13,"amount":14,"abstract":927},"cordis-european-research-council-award-101059920","Development of the next generation of 3D printed EMI shielding solutions based on 2D nanomaterials inks","With the fast development of wireless communication, especially the new 5G technology, electromagnetic interference (EMI) shielding is becoming a challenge. High-performance EMI shielding materials are urgently needed in controlling electromagnetic radiation pollution that seriously affects the normal operation of sensitive electronic apparatus and systems. Metals are the most used shielding materials but suffer from easy corrosion, high density, and poor processibility. Despite the progress, mo",{"id":929,"funder":7,"programme":8,"title":930,"piName":10,"institution":686,"country":85,"year":13,"amount":14,"abstract":931},"cordis-european-research-council-award-966614","CULTEXP: the first multilingual and cross-jurisdictional database on cultural expertise","Multicultural societies need cultural expertise for solving conflicts. Cultural expertise is to date provided by specialists as specialised and expensive services of expert witnessing and conflict settlement in court and out-of-court. Cultural expertise is not available outside specialised circles of legal professionals. In order to foster the transfer of knowledge about cultural expertise, EURO-EXPERT created CULTEXP as the first multilingual, cross-jurisdictional legal database on cultural exp",{"id":933,"funder":7,"programme":8,"title":934,"piName":935,"institution":936,"country":12,"year":13,"amount":10,"abstract":937},"openalex-european-research-council-award-erc-proof-of-concept-grant-899535","Mechanistic Investigations into the Selective Reduction of Oxygen by a MCO T3 site-inspired Copper Complex","Phebe H. van Langevelde","Leiden University","Understanding how multicopper oxidases (MCOs) efficiently and selectively reduce oxygen in the trinuclear copper cluster (TNC) is of great importance. Previously it was reported that when the T2-site is removed from the TNC, all O2 binding activity at the dinuclear T3-site is lost. Computational studies attribute this loss of activity to the flexibility of the protein active site, where the T3-copper centers move apart to minimize electrostatic repulsions. To address the question if and how a mo",{"id":939,"funder":7,"programme":8,"title":940,"piName":941,"institution":942,"country":12,"year":13,"amount":10,"abstract":943},"openalex-european-research-council-award-erc-proof-of-concept-grant-2019-pure-875649","Clean synthetic strategies to dopamine-based biologically active molecules from lignin: A green path to drug discovery","Anastasiia M. Afanasenko","University of Groningen","The structural complexity of renewable resources offers remarkable opportunities for the environmentally friendly manufacturing of essential pharmaceuticals, yet this has not been adequately addressed due to the lack of suitable methods. Our here described approach to drug discovery, builds on the innate structural features of the aromatic moiety of lignin to enable green pathways to various classes of biologically active molecules of the core dopamine structure. The catalytic transformations ar",198,{"programme":8,"total":946,"withPiName":947,"firstYear":948,"lastYear":949,"countryCount":950,"perYear":951,"topInstitutions":989,"topCountries":1057},2347,7,2014,2027,31,[952,954,957,959,962,965,968,971,974,975,978,981,984,987],{"year":948,"count":953},13,{"year":955,"count":956},2015,142,{"year":958,"count":956},2016,{"year":960,"count":961},2017,200,{"year":963,"count":964},2018,160,{"year":966,"count":967},2019,176,{"year":969,"count":970},2020,174,{"year":972,"count":973},2021,120,{"year":13,"count":944},{"year":976,"count":977},2023,231,{"year":979,"count":980},2024,237,{"year":982,"count":983},2025,265,{"year":985,"count":986},2026,264,{"year":949,"count":988},25,[990,993,996,999,1002,1005,1008,1011,1014,1016,1018,1021,1024,1027,1029,1032,1035,1037,1040,1042,1044,1046,1049,1052,1054],{"name":991,"count":992},"Centre National de la Recherche Scientifique CNRS",84,{"name":994,"count":995},"Weizmann Institute of Science",65,{"name":997,"count":998},"Technion - Israel Institute of Technology",43,{"name":1000,"count":1001},"The Chancellor Masters and Scholars of the University of Cambridge",42,{"name":1003,"count":1004},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",41,{"name":1006,"count":1007},"Fondazione Istituto Italiano di Tecnologia",34,{"name":1009,"count":1010},"Tel Aviv University",33,{"name":1012,"count":1013},"Imperial College of Science Technology and Medicine",32,{"name":1015,"count":1013},"Politecnico di Milano",{"name":1017,"count":950},"Institut National de la Sante Et de la Recherche Medicale",{"name":1019,"count":1020},"Ecole Polytechnique Federale de Lausanne",30,{"name":1022,"count":1023},"Universiteit Twente",29,{"name":1025,"count":1026},"The Hebrew University of Jerusalem",28,{"name":1028,"count":1026},"Universiteit Gent",{"name":1030,"count":1031},"The Chancellor, Masters and Scholars of the University of Oxford",27,{"name":1033,"count":1034},"Danmarks Tekniske Universitet",24,{"name":1036,"count":1034},"Vib Vzw",{"name":1038,"count":1039},"Katholieke Universiteit Leuven",23,{"name":1041,"count":1039},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",{"name":1043,"count":1039},"Technische Universitaet Muenchen",{"name":1045,"count":1039},"Technische Universiteit Delft",{"name":1047,"count":1048},"The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undivided Trinity of Queen Elizabeth Near Dublin",22,{"name":1050,"count":1051},"Technische Universiteit Eindhoven",21,{"name":1053,"count":1051},"Universiteit Leiden",{"name":1055,"count":1056},"Eidgenoessische Technische Hochschule Zuerich",20,[1058,1060,1062,1065,1067,1069,1071,1073,1075,1078,1080,1082,1084,1086,1088,1090,1091,1093,1095,1097,1099,1101,1104,1105,1108],{"name":170,"count":1059},299,{"name":60,"count":1061},273,{"name":1063,"count":1064},"UK",261,{"name":12,"count":1066},254,{"name":26,"count":1068},221,{"name":85,"count":1070},215,{"name":32,"count":1072},191,{"name":110,"count":1074},109,{"name":1076,"count":1077},"CH",85,{"name":296,"count":1079},72,{"name":20,"count":1081},62,{"name":274,"count":1083},50,{"name":677,"count":1085},48,{"name":490,"count":1087},47,{"name":79,"count":1089},40,{"name":496,"count":1056},{"name":159,"count":1092},19,{"name":54,"count":1094},17,{"name":512,"count":1096},12,{"name":340,"count":1098},11,{"name":245,"count":1100},10,{"name":1102,"count":1103},"PL",8,{"name":38,"count":1103},{"name":1106,"count":1107},"HU",5,{"name":1109,"count":1110},"HR",2]