[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-proof-of-concept-2023":3,"awarded-stats-erc-proof-of-concept":952},{"awarded":4,"total":951},[5,16,22,27,33,39,45,50,55,59,64,69,74,78,83,89,93,99,105,110,115,120,126,131,135,139,145,151,156,161,166,171,177,181,187,193,198,203,208,213,218,223,228,233,238,244,249,254,259,264,269,273,277,281,285,289,293,299,304,308,314,319,323,327,332,336,341,346,350,356,361,367,371,376,381,385,389,394,398,402,406,411,415,420,424,429,434,439,443,448,453,458,463,467,471,475,479,484,489,494,499,503,508,512,517,522,527,532,536,540,544,549,554,559,564,568,573,578,582,587,592,596,601,605,610,615,619,623,629,634,639,644,649,653,658,663,668,672,677,682,686,691,696,700,705,709,713,717,721,725,729,734,739,743,747,751,755,759,763,768,773,777,781,785,789,795,800,804,808,812,817,822,826,831,835,840,844,849,854,858,862,866,871,876,881,886,890,895,899,903,907,911,915,920,925,929,934,938,943,947],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-101069176","European Research Council","ERC Proof of Concept","EpiGrid: Soft and flexible high density electrode grids for epilepsy surgery",null,"UNIVERSITAIR MEDISCH CENTRUM UTRECHT","NL",2023,"€150,000","Epilepsy is a highly prevalent brain disorder affecting 1% of the population. Brain surgery can cure epilepsy if we can delineate the diseased tissue intra-operatively. Unfortunately this delineation is currently not performed precisely and leads to poor success rates (50-70%). High frequency oscillations (HFOs) have been identified as a biomarker of epileptogenic tissues, which can be electrically recorded with intraoperative electrocorticography. These HFOs are specific of diseased epileptogen",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":20,"year":13,"amount":14,"abstract":21},"cordis-european-research-council-award-101069461","PLant AdaptioN to Elevated Temperatures: mitigating crop losses caused by climate change","PLANET BIOTECH SL","ES","Agricultural ecosystems are severely pressed by global warming. Elevated temperature consequence of climate change is causing dramatic crop and economic losses while threaten the healthy and sustainable living standards of most European citizens. Predictions on increased ambient temperatures between 1.5-4ºC pose on danger food security globally for the coming years.  In the context of European Research Council (ERC) Consolidator Grant (IDRICA-683163), our lab found that vascular Brassinosteroid ",{"id":23,"funder":7,"programme":8,"title":24,"piName":10,"institution":25,"country":20,"year":13,"amount":14,"abstract":26},"cordis-european-research-council-award-101069349","Electrode assembly from floating nanowires for sustainable next generation batteries","FUNDACION IMDEA MATERIALES","“It is estimated that Europe needs an installed capacity for lithium-ion battery production of 300 GWh\u002Fyear by 2030. By then, the battery market for electric vehicles alone will be worth $116 billion annually. Amongst many technical challenges in this transition is to develop cost-effective and environmentally sustainable processes methods to manufacture high silicon (Si) content anodes for the next generation LIBs (3b and 4a). Si is more abundant than graphite and can enable higher power batter",{"id":28,"funder":7,"programme":8,"title":29,"piName":10,"institution":30,"country":31,"year":13,"amount":14,"abstract":32},"cordis-european-research-council-award-101067680","Auto-tuning, manipulation and braiding of topological quantum bits in tapered nanowire networks","WEIZMANN INSTITUTE OF SCIENCE","IL","Quantum computers will revolutionize multiple technology fields which will have a massive impact on society, in areas such as communication, healthcare, machine learning & artificial intelligence, finance, materials research and development and aerospace designing. Currently, the commercialization of quantum computers for real life applications is still a long shot due to major technical challenges like decoherence, a process in which the environment interacts with quantum bits and changes their",{"id":34,"funder":7,"programme":8,"title":35,"piName":10,"institution":36,"country":37,"year":13,"amount":14,"abstract":38},"cordis-european-research-council-award-101062237","New multisensory technology for early intervention in infants with visual impairment","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","IT","Visual impairments are disastrous for infants. They affect the infants’ reaching and motor skills, space perception, playing, socializing, physical functioning, psychological well-being, and health service needs. Therefore, early therapeutic interventions aimed explicitly at fostering these abilities are needed to improve the quality of life of people with visual disabilities. Effective rehabilitation technologies to enhance visually impaired infants' skills depend critically on a better underst",{"id":40,"funder":7,"programme":8,"title":41,"piName":10,"institution":42,"country":43,"year":13,"amount":14,"abstract":44},"cordis-european-research-council-award-101105488","Translating a new metabolic engineering strategy to industrial biotech applications","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","DE","Industrial biotechnology plays a key role on the road to a sustainable, climate-neutral and circular economy. However, disruptive innovations are needed to substantially increase the efficiency of bio-based processes for the production of chemicals. The ERC CoG project StrainBooster aimed to develop a generic metabolic engineering strategy to maximize the productivity of microbial cell factories. It is based on the concept of enforced ATP wasting (EAW), a targeted intervention in the energy meta",{"id":46,"funder":7,"programme":8,"title":47,"piName":10,"institution":48,"country":31,"year":13,"amount":14,"abstract":49},"cordis-european-research-council-award-101113412","Next-generation multi-targeted CRISPR genetic toolbox uncovers hidden breeding traits","TEL AVIV UNIVERSITY","The need to accelerate crop breeding programs has never been greater, as the world population is exponentially increasing, the climate is changing, and resources are limited. Breeding relies on genetic variation. However, it is impossible to alter many phenotypes by introducing genetic variation in a single gene due to large gene families with high functional redundancy. For example, in tomato and rice, ~80% of coding genes belong to multi-gene families. Therefore, in many cases, mutating multip",{"id":51,"funder":7,"programme":8,"title":52,"piName":10,"institution":53,"country":20,"year":13,"amount":14,"abstract":54},"cordis-european-research-council-award-101062190","Targeting RANK receptor as a novel therapeutic strategy in triple negative breast cancer","FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III","Breast cancer is the most common malignancy among females in the western world, resulting in nearly half a million deaths annually, mainly due to metastatic disease. Triple negative breast cancer (TNBC) accounts for almost 15–20% of all breast cancers (300.000 women diagnosed worldwide per year) and is commonly diagnosed in women younger than age 40. TNBC remains a clinical challenge due to high rate of relapse, a propensity to form visceral metastasis and limited targeted therapies. Thus, there",{"id":56,"funder":7,"programme":8,"title":57,"piName":10,"institution":42,"country":43,"year":13,"amount":14,"abstract":58},"cordis-european-research-council-award-101112937","Holographic Assembler for 3D Cell Cultures","Cell cultures are essential for biomedical research and drug screening. The environment and the arrangement directly affect cell function. It has become clear that biological cells behave differently when cultured on a surface as opposed to a 3D environment. This discrepancy between 2D in vitro studies and the 3D environment found in vivo is critical for cancer research, most notably patient-specific therapy and high-throughput drug screening and discovery. Almost 90% of all drug candidates fail",{"id":60,"funder":7,"programme":8,"title":61,"piName":10,"institution":62,"country":12,"year":13,"amount":14,"abstract":63},"cordis-european-research-council-award-101112687","Novel therapeutic platform for aggressive lymphoma: NanoLymphoma","STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM","Immunotherapy using antibodies targeting the cell surface has led to important clinical advances in patients with cancer, exemplified by CD20-antibodies that are first-line treatment in patients with B-cell lymphoma. However, diffuse large B-cell lymphoma (DLBCL), the most common and aggressive form of B-cell lymphoma worldwide, is still incurable in 40% of patients. These patients have poor prognosis due to treatment failure or relapse upon therapy with CD20-antibodies (260,000 mortalities worl",{"id":65,"funder":7,"programme":8,"title":66,"piName":10,"institution":67,"country":31,"year":13,"amount":14,"abstract":68},"cordis-european-research-council-award-101101061","Targeted insula stimulations as treatment for autoimmune disorders","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","Inflammatory bowel diseases (IBD) are a group of chronic inflammatory conditions affecting the gastrointestinal (GI) tract, including Crohn’s and Ulcerative colitis. The prevalence of IBD has been increasing globally and almost doubled from 3.7 million in 1990 to 6.8 million in 2017, with the highest prevalence rates observed in Europe and North America (422 cases per 100,000 population). Patients with IBD suffer from chronic relapsing abdominal pain, urgency and incontinence, and depending on t",{"id":70,"funder":7,"programme":8,"title":71,"piName":10,"institution":72,"country":31,"year":13,"amount":14,"abstract":73},"cordis-european-research-council-award-101113386","An injectable and programmable drug-eluting embolic device","THE HEBREW UNIVERSITY OF JERUSALEM","This project aims to develop a novel platform for drug delivery and treatment for liver cancers. A first in its kind two-step acting platform is described in detail depicting an early step of drug elusion to viable tissue (in contrast to acute embolism) followed by a later stage of vessel blockage to induce tissue necrosis is introduced here. Inspired by the coronary drug eluting stent concept we will introduce a novel porous degradable bead referred as EmboPore used as mini-stents that can elut",{"id":75,"funder":7,"programme":8,"title":76,"piName":10,"institution":48,"country":31,"year":13,"amount":14,"abstract":77},"cordis-european-research-council-award-101113390","Modular Targeted Nanoplatform for Immune Cell Regulation and Therapy","Cancer is a major cause of disability and mortality worldwide. The striking rise of immunotherapies has transformed the way we prevent and treat cancer. Nevertheless, despite the promising clinical results of immunotherapies, they suffer from multiple limitations, including manufacturing challenges, limited efficacy, toxicity, and high costs. Recent data highlight the promising role of personalized cancer vaccines in inducing effective antitumor immunity in patients suffering from aggressive for",{"id":79,"funder":7,"programme":8,"title":80,"piName":10,"institution":81,"country":20,"year":13,"amount":14,"abstract":82},"cordis-european-research-council-award-101081713","Intelligent Device and Computational Software to Control Mechanical Stress and Deformation for Biological Testing","UNIVERSIDAD CARLOS III DE MADRID","In nature, all biological material from the cell to the tissue level is subjected to continuous mechanical stress and strain. These mechanical cues play an essential role on several biological processes and can determine the fate of a healing or a cancerous process, among many others. Therefore, research activities focusing on studying the deterministic nature of these processes need a robust test platform that allows for reproducing these mechanically-varying environments. Such a system would s",{"id":84,"funder":7,"programme":8,"title":85,"piName":10,"institution":86,"country":87,"year":13,"amount":14,"abstract":88},"cordis-european-research-council-award-101100769","Live biotherapeutics to potentiate cancer immunotherapy","UNIVERSITY OF CYPRUS","CY","Immunotherapy, including immune checkpoint inhibitors (ICIs), has revolutionized the treatment of multiple cancers. Anti-tumor responses are often durable but overall only a subset of patients receiving ICIs has exhibited sustained tumor shrinkage, whereas a substantial fraction receiving these therapies develops immune-related adverse events. The absence of dramatic responses is attributed to several factors, including abnormalities in the tumor microenvironment (TME). Specifically, many tumors",{"id":90,"funder":7,"programme":8,"title":91,"piName":10,"institution":67,"country":31,"year":13,"amount":14,"abstract":92},"cordis-european-research-council-award-101113389","Focused Targeting of Inhaled Magnetic Aerosols for Lung Cancer","The pulmonary tract is an attractive route for direct treatments of lung diseases. Yet, our ability to confine the deposition of inhalation aerosols to specific lung regions, and notably local airways, remains still widely beyond reach with common inhalation therapy. It has been hypothesized that by coupling magnetic particles to inhaled therapeutics the ability to locally target airway sites can be substantially improved. Yet, virtually all practical implementations to date have come short of d",{"id":94,"funder":7,"programme":8,"title":95,"piName":10,"institution":96,"country":97,"year":13,"amount":14,"abstract":98},"cordis-european-research-council-award-101100823","High-throughput combinatory drugs testing on in vitro 3D cells model platform","ECOLE SUPERIEURE DE PHYSIQUE ET DECHIMIE INDUSTRIELLES DE LA VILLE DEPARIS","FR","Drug combinations can lead to the discovery of novel drugs by increasing efficacy or lowering toxicity through synergy. This can boost existing drugs, rescue drug candidates, and accelerate drug discovery for yet poorly addressed diseases. However, predicting synergy is difficult, and finding synergies requires high-throughput screening (HTS) in advanced cell models. Current solutions propose either HTS in 2D cell cultures or low throughput assays in 3D cell cultures, but not both.On the basis o",{"id":100,"funder":7,"programme":8,"title":101,"piName":10,"institution":102,"country":103,"year":13,"amount":14,"abstract":104},"cordis-european-research-council-award-101100597","Taking blood apart by sound","LUNDS UNIVERSITET","SE","Separation of blood components is of high importance in healthcare and often require fractionation of blood in its subcomponents by centrifugation. There are several scenarios that calls for improved resolution:1.When blood is drawn from a donor and a specific cell type is extracted while returning remaining blood components.2.In cancer immunotherapy where T-cells are isolated from the blood and then genetically reprogrammed to be re-infused in the patient where they seek up and destroy cancer c",{"id":106,"funder":7,"programme":8,"title":107,"piName":10,"institution":108,"country":12,"year":13,"amount":14,"abstract":109},"cordis-european-research-council-award-101111870","Small molecule heparanase inhibitors as anti-metastatic cancer drugs","UNIVERSITEIT LEIDEN","The Heparanib Proof-of-Concept project aims to establish the feasibility of our unique small molecule heparanase inhibitors as drug candidates for the treatment of metastatic cancers. To strengthen our science case (experimental development A) and by building on our in vivo data in mouse models for metastatic breast cancer, lung cancer and multiple myeloma, we will (A-I) design a suitable route of synthesis to prepare sufficient quantities of clinical grade material; (A-II) synthesise reference ",{"id":111,"funder":7,"programme":8,"title":112,"piName":10,"institution":113,"country":97,"year":13,"amount":14,"abstract":114},"cordis-european-research-council-award-101113026","Ruthenium-containing Polymers against Ovarian Cancers","ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS","Nearly 250,000 women are diagnosed each year with ovarian cancer around the world, resulting in 140,000 deaths. High-grade epithelial ovarian cancer (EOC) is the deadliest gynecologic cancer, ranking fifth overall in cancer deaths. The majority of women have widespread intra-abdominal disease at the time of diagnosis, and the 5-year survival rate for these women is only about 40% after receiving standard therapy. Currently, the standard first-line treatment for ovarian cancer consists of surgica",{"id":116,"funder":7,"programme":8,"title":117,"piName":10,"institution":118,"country":12,"year":13,"amount":14,"abstract":119},"cordis-european-research-council-award-101101050","Mucinase-based innovative therapy to enhance cancer treatment","UNIVERSITEIT UTRECHT","Colorectal carcinoma (CRC) is one of the leading causes of cancer death in women and men. CRC can be broadly subdivided into adenocarcinoma-type and mucinous-type CRC, characterised by an overproduction of mucin proteins which is the primary component of mucus. These mucins form a 'physical barrier' that impedes the accessibility of current CRC therapies to their target receptors, limiting what would otherwise be promising cancer drugs.Dr. Karin Strijbis' group has discovered a compelling mucina",{"id":121,"funder":7,"programme":8,"title":122,"piName":10,"institution":123,"country":124,"year":13,"amount":14,"abstract":125},"cordis-european-research-council-award-101113272","Achieving the golden Grail in solid tumor treatment","SZKOLA GLOWNA GOSPODARSTWA WIEJSKIEGO","PL","Macrophage therapy is promising for solid tumor treatment as these cells are continuously recruited into the tumor mass, even the most hypoxic regions. Our pioneering research demonstrated that macrophages are able to take up ferritins loaded with anti-cancer drugs, creating Macrophage-Drug Conjugates (MDCs), and transfer these to cancer cells and kill them, a phenomenon we named TRAIN. In my ongoing ERC Starting Grant PROJECT McHAP, we have proven that MDCs can be sucessfully used not only to t",{"id":127,"funder":7,"programme":8,"title":128,"piName":10,"institution":129,"country":97,"year":13,"amount":14,"abstract":130},"cordis-european-research-council-award-101059236","Diagnose Alzheimer’s disease with isotopes","INSTITUT DE PHYSIQUE DU GLOBE DE PARIS","During the course of the PRISTINE proposal we have developed the first high precision high sensitivity stable isotope measurements for a variety of vital elements, including Zn, and Cu . With these technical advances we realized that we could monitor stable isotopic changes within organisms that open up a new way to study metal homeostasis as well as a new ways of detection diagnosis for diseases, in particular the Alzheimer's disease. In DAI, we will further explore make use of these unique tec",{"id":132,"funder":7,"programme":8,"title":133,"piName":10,"institution":48,"country":31,"year":13,"amount":14,"abstract":134},"cordis-european-research-council-award-101100664","Deep Label-Free Cell Imaging of Liquid Biopsies for Cancer Monitoring","We will develop and commercialize an innovative device for diagnosis and monitoring of cancer in liquid biopsies based on a label-free interferometric phase microscopy (IPM) unit, coupled with dedicated real-time artificial intelligence (AI) for cell classification. This device will materialize an innovative approach for the much-anticipated imaging flow cytometry, dramatically decreasing its costs, and improving patient care by accurate monitoring of cancer in the clinical lab from a simple lab",{"id":136,"funder":7,"programme":8,"title":137,"piName":10,"institution":67,"country":31,"year":13,"amount":14,"abstract":138},"cordis-european-research-council-award-101101048","Lossless Electron Beam Monochromator for Enhanced Resolution in Electron Microscopy","Lossless Electron Beam Monochromator for Enhanced Resolution in Electron MicroscopyThe performance of advanced high-resolution electron-microscopes (EM) is severely limited by the energy spread of the electron beam, which limits both spatial and spectral resolutions by causing chromatic aberrations. To mitigate this limitation, monochromators are used. Common monochromators have mechanical slits as a narrow band-pass filter, inherently introducing high loss to the electron beam. They are very co",{"id":140,"funder":7,"programme":8,"title":141,"piName":10,"institution":142,"country":143,"year":13,"amount":14,"abstract":144},"cordis-european-research-council-award-101101072","Low-cost, high-throughput quantitative phase microscopy","DANMARKS TEKNISKE UNIVERSITET","DK","High-content screening is rapidly gaining traction across the biological sciences as a means to acquire more detailed data and test more hypotheses in an unprecedentedly rapid and systematic manner. However, a key issue identified by its users is that the instrumentation costs are too high, with systems typically costing from €150.000-800.000. This limits ownership of the instruments to well-funded research labs and, in doing so, excludes a significant portion of the multi- billion USD potential",{"id":146,"funder":7,"programme":8,"title":147,"piName":10,"institution":148,"country":149,"year":13,"amount":14,"abstract":150},"cordis-european-research-council-award-101113439","Next-gen fluorescence imaging for research and theranostics","KATHOLIEKE UNIVERSITEIT LEUVEN","BE","Fluorescence microscopy is key technique in the life sciences, though the method struggles to deliver the fast and sensitive imaging of multicellular systems. Such samples are now becoming commonplace not only in research but also in clinical use, including spatially-resolved 'omics' and theranostics based on patient material that allow the development of personalized treatments. However, their general uptake is limited by the absence of suitable instrumentation.As part of our ERC-funded researc",{"id":152,"funder":7,"programme":8,"title":153,"piName":10,"institution":154,"country":12,"year":13,"amount":14,"abstract":155},"cordis-european-research-council-award-101113313","Sputtering Halide Perovskites for Integration in Monolithic Tandem Solar Cells","UNIVERSITEIT TWENTE","Perovskite-silicon tandem solar cells are one of the most promising new technologies in solar energy research, due to their high efficiencies and use of low-cost materials. One attractive way to make these tandems is to grow the wide band gap perovskite on textured silicon solar cells, forming a monolithic tandem. Record efficiencies of 31.25% have been reported for these monolithic tandems, but still on relatively small area devices (1 cm2). To bring this technology closer to the market, it is ",{"id":157,"funder":7,"programme":8,"title":158,"piName":10,"institution":159,"country":37,"year":13,"amount":14,"abstract":160},"cordis-european-research-council-award-101068936","Engineering Water Repellent Coatings by Functional Nano-Sponges: a Springboard to Stable Perovskite Devices (SPIKE)","UNIVERSITA DEGLI STUDI DI PAVIA","The SPIKE project aims at realizing a revolutionary water repellent coating as a functional barrier to encapsulate photovoltaic (PV) electronic devices. Global solar encapsulation industry, massively pushed by the urgent increase in the solar energy demand, is expected to reach $11.37 billion by 2028 with a growing rate of 14.5% during the forecast period (2021 - 2028). Solar encapsulation is key to provide excellent durability to a PV module, an essential pre-requisite for its commercial viabil",{"id":162,"funder":7,"programme":8,"title":163,"piName":10,"institution":164,"country":12,"year":13,"amount":14,"abstract":165},"cordis-european-research-council-award-101080830","Improving Peptide-Based Anti-Cancer Vaccines with Phosphatase Inhibitors","RIJKSUNIVERSITEIT GRONINGEN","Peptides have great potential for vaccines. Peptide-based vaccines aim to increase the population and activity of pathogen\u002Fcancer-recognizing T cells by administering antigenic peptides carrying epitopes for major histocompatibility (MHC) class I and II. These peptides are endocytosed by dendritic cells (DCs), followed by intracellular proteolytic processing to release the epitopes, the loading of the epitopes on MHC, and finally the presentation to antigen-specific T cells. Despite numerous stu",{"id":167,"funder":7,"programme":8,"title":168,"piName":10,"institution":169,"country":20,"year":13,"amount":14,"abstract":170},"cordis-european-research-council-award-101112813","Heterogeneous biocatalysts for oxygen-independent oxidations using inorganic salts","ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE","The vast majority of industrial chemical oxidations catalyzed by heterogeneous catalysts (chemical and enzymatic) in aqueous solvents suffer from several technical hindrances related to diffusion restrictions of oxygen This limitation derives from the low transport rate of molecular oxygen from the gas phase to the solvation sheath on the surface of the solid catalyst where catalysis occurs. The restriction of molecular oxygen availability at the reaction point creates a bottleneck in the produc",{"id":172,"funder":7,"programme":8,"title":173,"piName":10,"institution":174,"country":175,"year":13,"amount":14,"abstract":176},"cordis-european-research-council-award-101101040","Targeting peripheral nerves: a method for therapeutic modulation of inflammatory disease with non-invasive temporal interference","FAKULTNI NEMOCNICE U SV ANNY V BRNE","CZ","Excessive inflammation underlies the development of inflammatory diseases, e.g. Rheumatoid arthritis, Crohn's Disease, inflammatory bowel disease, and cardiovascular disease - the most common cause of death in the world. Human physiology is controlled by defined molecular mechanisms, commonly controlled by specific target nerves and their associated reflexes which optimize function – for example molecular mechanisms regulating inflammation. Harnessing the power of the inherent nerve reflexes whi",{"id":178,"funder":7,"programme":8,"title":179,"piName":10,"institution":102,"country":103,"year":13,"amount":14,"abstract":180},"cordis-european-research-council-award-101113364","Neoantigen Identification with Dendritic Cell Reprogramming","In cancer, genetic mutations result in production of tumor neoantigens restrictively expressed in transformed cells and serve as ideal molecular targets for cancer vaccines and adoptive T cell therapies. However, available methods for the identification of clinically relevant neoantigens driving potent anti-tumor immunity are highly inefficient. Thus, there is an urgent need for innovative solutions to identify powerful immunogenic neoantigens to unlock the full potential of immunotherapy and tr",{"id":182,"funder":7,"programme":8,"title":183,"piName":10,"institution":184,"country":185,"year":13,"amount":14,"abstract":186},"cordis-european-research-council-award-101113534","Building consensus for a new approach to breast cancer prevention in women with a BRCA1 mutation","UNIVERSITAET INNSBRUCK","AT","Women with germline mutations in the BRCA1 genes face a 40-fold increased risk of developing breast and ovarian cancer. As a result, and due to a lack of other options, many women with a BRCA1 mutation choose to undergo drastic risk reducing surgery (removal of both breasts, ovaries and Fallopian Tubes) when they are still very young. Drugs currently recommended for prevention of breast cancer, such as tamoxifen or aromatase inhibitors, do not prevent those cancers with the poorest prognosis, su",{"id":188,"funder":7,"programme":8,"title":189,"piName":10,"institution":190,"country":191,"year":13,"amount":14,"abstract":192},"cordis-european-research-council-award-101100718","2D Topological Superconducting Single Photon Detector Devices","KOC UNIVERSITY","TR","Superconducting single photon detectors are critical components for emerging quantum technologies due to their high detection efficiencies, short jitter, photon number resolution, high maximum and low dark count rates. These devices may enable new ground-breaking applications in topological quantum computing and quantum internet. Niobium-based nanowires (Nb, NbN) are some of the most used superconductors for photodetection, but their material characteristics, device jitter and efficiencies canno",{"id":194,"funder":7,"programme":8,"title":195,"piName":10,"institution":196,"country":43,"year":13,"amount":14,"abstract":197},"cordis-european-research-council-award-101113104","Rapid Programmable Photonic Integrated Circuits","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","Photonic integrated circuits enable trapping of photons, the fundamental particles of light, in a waveguide on a chip to allow their manipulation, similar to electrons in classical integrated circuits. While photonic circuits offer superior performance in speed and energy efficiency, their application in computing has so far been limited by their programmability. Electronic integrated circuits are based on transistors that until recently have become both smaller and more energy-efficient accordi",{"id":199,"funder":7,"programme":8,"title":200,"piName":10,"institution":201,"country":185,"year":13,"amount":14,"abstract":202},"cordis-european-research-council-award-101082147","Human blastoids: a drug discovery platform for women’s reproductive health","INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH","The first weeks of human pregnancy are crucial as early abnormalities or insults result in infertility. Therapeutics acting at the onset of embryonic development would offer huge opportunities to improve public health through effective family planning and to reduce an ongoing global fertility decrease with profound economic, social, environmental, and geopolitical consequences. Unfortunately, a drug development program on human embryos is unfeasible due to the inaccessibility and scarcity of emb",{"id":204,"funder":7,"programme":8,"title":205,"piName":10,"institution":206,"country":149,"year":13,"amount":14,"abstract":207},"cordis-european-research-council-award-101059468","High-Quality Graphene Supports for Microspectroscopic Techniques.","UNIVERSITEIT ANTWERPEN","Transmission electron microscopy (TEM) is a powerful technique to fully characterise the local structure of a broad range of materials. Due to many recent hardware advances, the quality of TEM measurements is nowadays ultimately determined by the sample supports. Surprisingly though, their importance has been majorly overlooked so far. The many benefits of graphene layers as a support have been well-recognised by the community, but commercial “graphene grids” show poor coverage and are dominated",{"id":209,"funder":7,"programme":8,"title":210,"piName":10,"institution":211,"country":37,"year":13,"amount":14,"abstract":212},"cordis-european-research-council-award-101112677","A multiscale Machine Learning based Software for the Simulation of Catalytic Processes","POLITECNICO DI MILANO","The reduction of the environmental footprint of the chemical and related industries is nowadays of utmost importance. The transition towards more sustainable processes that combine efficient use of raw material and energy with higher transformation rates, better selectivity and higher mass and energy efficiency will contribute to meet the objectives of the green deal. In this respect, catalysis engineering is pivotal to developing technologies able to meet these goals and to shape the sustainabl",{"id":214,"funder":7,"programme":8,"title":215,"piName":10,"institution":216,"country":20,"year":13,"amount":14,"abstract":217},"cordis-european-research-council-award-101112805","Computational design of industrial enzymes for green chemistry","UNIVERSITAT DE GIRONA","Catalysts are able to reduce activation barriers of reactions making them possible at lower pressure an temperatures. Enzymes are the most efficient, specific, and selective catalysts known. Green chemistry has emerged as a new area focusing on use of environmentally friendly, non-hazardous and efficient solvents and catalysts in the synthesis of new products. Enzymes are non-toxic, and capable of operating under mild biological conditions, which makes them green catalysts offering an attractive",{"id":219,"funder":7,"programme":8,"title":220,"piName":10,"institution":221,"country":103,"year":13,"amount":14,"abstract":222},"cordis-european-research-council-award-101113487","Personalised Bioelectronics for Epithelial Repair","CHALMERS TEKNISKA HOGSKOLA AB","Care of chronic wounds constitutes an enormous socioeconomic burden to the European Healthcare system calling for new strategies to support healing for wounds at risk. As a restored epithelium will outperform any artificial scaffold in protecting the underlying tissue, fast re-epithelialization is the primary goal. In culture models of wound healing, we have shown that direct current stimulation (DCs) makes epithelial ruptures close up to three times faster, and that the key to success is dosage",{"id":224,"funder":7,"programme":8,"title":225,"piName":10,"institution":226,"country":191,"year":13,"amount":14,"abstract":227},"cordis-european-research-council-award-101113438","Rapid Microplastic Analysis by Microparticle Radars","BILKENT UNIVERSITESI VAKIF","Microplastics pollution is becoming increasingly problematic due to its involvement in a myriad of health problems and its effects on natural wildlife. Water agencies across the globe are progressively implementing screening policies for drinking water to address this issue. However, this is proving to be challenging since the existing monitoring technologies are labor intensive and time-consuming with low throughput. To address the issue, we propose a new flow-through sensor that builds upon te",{"id":229,"funder":7,"programme":8,"title":230,"piName":10,"institution":231,"country":97,"year":13,"amount":14,"abstract":232},"cordis-european-research-council-award-101112716","Real-time measurements of oceanic waves using connected buoys and mobile stations","ECOLE NORMALE SUPERIEURE PARIS-SACLAY","The ERC Advanced Grant HIGHWAVE is a current project that studies the physical mechanisms underlying the emergence of destructive breaking waves on the ocean’s surface. The recent months have shown the multiplication of abnormal atmospheric disturbances generating extreme winds and waves that surprised forecasters. It is therefore essential to be able to extract useful information from real-time measurements of winds and waves. In planning to address this problem from a science perspective, we d",{"id":234,"funder":7,"programme":8,"title":235,"piName":10,"institution":236,"country":185,"year":13,"amount":14,"abstract":237},"cordis-european-research-council-award-101069344","Optical imaging platform for high-throughput longitudinal studies of the eye in disease models","MEDIZINISCHE UNIVERSITAET WIEN","Loss of vision is frequently related to disorders of the retina that may be either primary or secondary such as involvement in metabolic or neurologic disorders. Since the retina constitutes an easily accessible outpost of the brain, it emerged as top research target for non-invasive diagnostics of neurological diseases such as Alzheimer’s disease. Preclinical testing in rodents is an essential element in the process of exploring novel therapeutic compounds. The gold standard for such research a",{"id":239,"funder":7,"programme":8,"title":240,"piName":10,"institution":241,"country":242,"year":13,"amount":14,"abstract":243},"cordis-european-research-council-award-101101005","Solar cYcle prediCtion tool using sOlar internal oscillations (SYCOS)","AALTO KORKEAKOULUSAATIO SR","FI","Short- and long-term prediction of solar activity and space weather are long-standing problems, affecting the society at a large scale: being able to issue a prediction earlier and more reliably will prevent economic losses for industries, space sector, and governments. During our ongoing ERC CoG project UniSDyn, we have numerically and observationally demonstrated the potential of a novel data product, the internal surface gravity oscillation mode, tracing the sub-surface magnetic field in the ",{"id":245,"funder":7,"programme":8,"title":246,"piName":10,"institution":247,"country":20,"year":13,"amount":14,"abstract":248},"cordis-european-research-council-award-101100665","CD22\u002FCD19 dual redirection Dual targeting of CD22 and CD19 with BiTE-secreting and CAR-expressing bispecific T-cells for adoptive Cellular ImmunoTherapy in advanced B-cell Acute Lymphoblastic Leukemia","FUNDACIO INSTITUT DE RECERCA CONTRA LA LEUCEMIA JOSEP CARRERAS","Anti-CD19 immunotherapies based on Bi-specific T-cell Engagers (BiTE) or chimeric antigen receptor (CAR)-expressing T-cells have revolutionized the treatment of refractory\u002Frelapse (R\u002FR) B-cell acute lymphoblastic leukemia (B-ALL). However, despite initial impressive complete response (CR) rates, many patients relapse few months after anti-CD19 immunotherapy; in many cases with CD19 antigen loss. Such relapses are devastating, and patients are left with virtually no further treatment options. Dua",{"id":250,"funder":7,"programme":8,"title":251,"piName":10,"institution":252,"country":20,"year":13,"amount":14,"abstract":253},"cordis-european-research-council-award-101113416","A precise and versatile nanotechnology with seed bio-stimulant microbial molecules to potentiate crop growth and immunization","UNIVERSIDAD DE MALAGA","Seed germination is the first step of a sequence of events that promote the transit of seeds from dormancy to vegetative growth. Therefore, it is a tightly regulated program that ensures further plant growth and survival in a supportive environment. The emergency provoked by continuous deterioration of the environment due to non-respectful crop management strategies and potentiated with climate change has increased the focus on this primordial stage of the plant growth as a primary target of str",{"id":255,"funder":7,"programme":8,"title":256,"piName":10,"institution":257,"country":103,"year":13,"amount":14,"abstract":258},"cordis-european-research-council-award-101113141","Virtual tissue staining by deep learning","GOETEBORGS UNIVERSITET","Our goal is to create a virtual tissue-staining device to replace manual chemical-staining techniques by integrating optics and deeplearning.Chemical staining of cell components plays an essential role in biomedical and pharmaceutical research and practice. Cell structuresof interest are highlighted using various chemical stains and imaged with the appropriate optical setup. However, these techniquesare often invasive and sometimes even toxic to the cells, in addition to being time consuming, la",{"id":260,"funder":7,"programme":8,"title":261,"piName":10,"institution":262,"country":37,"year":13,"amount":14,"abstract":263},"cordis-european-research-council-award-101113522","Kits for advanced polymer-lipid nanocarriers for targeted delivery of RNAs to cardiac and skeletal muscle cells","POLITECNICO DI TORINO","Currently, RNA therapies are available on the clinics to treat liver diseases and as COVID-19 vaccines. Hence, their therapeutic potential still remains largely unexploited for the treatment of other disorders, such as age-related, rare genetic and infectious diseases. One key problem for effective preclinical research on new RNA therapies is the lack of safe, efficient and cell-specific delivery vehicles. Gold-standard cationic lipid transfection reagents suffer from dose-dependent cytotoxicity",{"id":265,"funder":7,"programme":8,"title":266,"piName":10,"institution":267,"country":12,"year":13,"amount":14,"abstract":268},"cordis-european-research-council-award-101101043","Engineering of low germination stimulant production to control witchweed infection in maize in Sub-Saharan Africa","UNIVERSITEIT VAN AMSTERDAM","The parasitic witchweeds, such as Striga hermonthica and Striga asiatica, pose an enormous threat for production of cereal crops, such as sorghum, millet and maize, in the African continent, threatening the livelihood of millions of people, especially in sub-Saharan Africa. Striga seeds lay dormant in the soil until their germination is triggered by strigolactones (SLs), signaling compounds exuded by roots of plants, including maize. Maize exudes at least six different SLs from its roots into th",{"id":270,"funder":7,"programme":8,"title":271,"piName":10,"institution":267,"country":12,"year":13,"amount":14,"abstract":272},"cordis-european-research-council-award-101101042","Atlas of the Human Deep Brain Nuclei, Connections, and Vasculature","Deep-brain stimulation, DBS in short, is one of the most promising surgical treatments for movement disorders such as Parkinson’s disease (PD), and more recently, neuropsychiatric diseases such as obsessive compulsive disorder. During DBS surgery, a microelectrode is lowered deep into the brain with the aim to stimulate small subcortical nuclei in order to alleviate disease related symptoms such as rigidity and tremor as seen in patients with PD. Studies using DBS in PD patients show that a subo",{"id":274,"funder":7,"programme":8,"title":275,"piName":10,"institution":142,"country":143,"year":13,"amount":14,"abstract":276},"cordis-european-research-council-award-101113483","Highly-Efficient Seeded Frequency Comb Generation on a Chip","Generating new colors (frequency components) of light through nonlinear optical phenomena is one of the key drivers of modern optical technology. The spectrally diverse coherent light, widely known as an optical frequency comb, can be produced through a nonlinear process. The optical frequency comb enables energy-efficient optical communication, precision spectroscopy, and optical atomic clock. However, the frequency comb sources currently rely on bulky and power-hungry laser systems hampering t",{"id":278,"funder":7,"programme":8,"title":279,"piName":10,"institution":142,"country":143,"year":13,"amount":14,"abstract":280},"cordis-european-research-council-award-101113532","Laboratory-based Imaging of Microstructure in Polymers","Polymers are increasingly used as a lightweight and more sustainable alternative to traditional materials like steel. However product developers are not using the polymer materials to their full potential since they don’t fully trust the models of strength and longevity. Having information about the material properties in the bulk of the components during the product development stage will provide this trust. Based on decades of experience from x-ray characterization and instrumentation, our tea",{"id":282,"funder":7,"programme":8,"title":283,"piName":10,"institution":142,"country":143,"year":13,"amount":14,"abstract":284},"cordis-european-research-council-award-101112851","AIDA: Allergy Immunotherapy based on Designed Allergens","Allergy is a severe immune reaction to foreign substances known as allergens, with respiratory and food allergies affecting 30% and 10% of the global population, respectively. A high structural similarity exists between pollen and food allergens. Therefore, many people suffer from both types of allergies. Untreated allergies have detrimental effects on health-related quality of life, family economics, and work attendance. Allergy is treated as a chronic disease, with a focus on reducing symptoms",{"id":286,"funder":7,"programme":8,"title":287,"piName":10,"institution":42,"country":43,"year":13,"amount":14,"abstract":288},"cordis-european-research-council-award-101082172","Sustainable pigments and glitter from renewable cellulose","Inspired by nature, we developed effect pigments prepared from a single organic and renewable component extracted from plants: cellulose nanocrystals. Obtained via self-assembly, these pigments offer one of the most sustainable alternatives to all existing products, including microplastic, partially biodegradable glitter, and unsustainably sourced mica- and titania-based pigments. Securing this ERC-2022-PoC2 proposal will allow us to bring this much-needed technology from TRL6 to TRL7 by address",{"id":290,"funder":7,"programme":8,"title":291,"piName":10,"institution":102,"country":103,"year":13,"amount":14,"abstract":292},"cordis-european-research-council-award-101113278","Pharmacoepigenetics for precision medicine in type 2 diabetes","The prevalence of diabetes will rise to ~592 million in 2035. Type 2 diabetes (T2D) is a leading cause of death through its vascular complications. High glucose increases the risk for complications, and thereby suffering for patients and costs for society. It is important that patients with T2D receive an optimal therapy that lowers blood glucose. Metformin is first-line T2D therapy. However, ~30% of patients do not respond to metformin. Currently, there are no biomarkers that predict the respon",{"id":294,"funder":7,"programme":8,"title":295,"piName":10,"institution":296,"country":297,"year":13,"amount":14,"abstract":298},"cordis-european-research-council-award-101113553","Radiation-detected NMR: new dimension for Magnetic Resonance spectroscopy and imaging","ORGANISATION EUROPEENNE POUR LA RECHERCHE NUCLEAIRE","CH","Nuclear magnetic resonance (NMR) is a powerful spectroscopic technique, used in various fields, including chemistry, biology and medicine. However, conventional NMR has one big limitation, namely very small sensitivity, due to a low level of polarisation of nuclear spins and inefficient signal detection by an induction signal in pick-up coils. My ERC Starting grant has explored the use of radiation-detected NMR (RD-NMR), in which very short-lived nuclei were used as novel NMR probes, bringing up",{"id":300,"funder":7,"programme":8,"title":301,"piName":10,"institution":302,"country":20,"year":13,"amount":14,"abstract":303},"cordis-european-research-council-award-101081926","ClimateJusticeReady","UNIVERSITAT AUTONOMA DE BARCELONA","Cities in the Global North are increasingly adopting nature-centered and other green infrastructure interventions to respond to climate risks and impacts and enhance their adaptation and resilience capacity. Yet, plans for such green infrastructure (GI) and other urban greening interventions tend to underestimate risks of displacement for lower-income and minority residents – what myself and others have previously called green climate gentrification. Despite increasing recognition of this proces",{"id":305,"funder":7,"programme":8,"title":306,"piName":10,"institution":118,"country":12,"year":13,"amount":14,"abstract":307},"cordis-european-research-council-award-101081573","Scalable Knowledge-Aware Image Caption Generation","Image captioning is the process of mapping a visual scene to a short textual description. Automating this process is vital for many computer applications, including information retrieval from visual data, computerized assistance to visually impaired people, and automatic tour guiding. State-of-the-art captioning systems are limited by their heavy reliance on visual contents. As a result, generated captions are often purely descriptive and miss important information that is needed in order to und",{"id":309,"funder":7,"programme":8,"title":310,"piName":10,"institution":311,"country":312,"year":13,"amount":14,"abstract":313},"cordis-european-research-council-award-101113346","Social Cognitive Interventions following Adverse early Life Experiences","UNIVERSITY OF GALWAY","IE","The affective and cognitive consequences of childhood trauma are experienced across the life span, and are associated with poorer mental and physical health outcomes in those affected. While trauma-focused psychological therapies successfully address the affective consequences of childhood trauma, the cognitive consequences have been poorly understood and managed despite being highly predictive of poorer social and occupational outcomes. SOCIAbLE is a novel psychosocial intervention that targets",{"id":315,"funder":7,"programme":8,"title":316,"piName":10,"institution":317,"country":37,"year":13,"amount":14,"abstract":318},"cordis-european-research-council-award-101100643","EU Face Advanced Communication for Elders Treasuring in Society","UNIVERSITA DEGLI STUDI DI TORINO","EUFACETS aims at maximising the value of the ERC Consolidator Project FACETS by developing a family-oriented social network app based on visage. Some faces were excluded from the forced digitalization of all faces due to the increasing digitalisation of our lives, accelerated by the Covid-19 pandemic: those of the elders. The pandemic was just underlining an already existing issue: face-based social networks have been designed by young people for young people. They focus on connecting people who",{"id":320,"funder":7,"programme":8,"title":321,"piName":10,"institution":148,"country":149,"year":13,"amount":14,"abstract":322},"cordis-european-research-council-award-101113450","Sounds of Royalty: Accessing Valois Soundscapes (c. 1400) Digitally","The VALSOUNDS project will design a prototype multimedia digital valorisation tool that allows museums and cultural heritage institutions to highlight the sonic aspects of their collections or sites. This will be done through an innovative, immersive (3-D, AR) digital interface with a focus on audio. Existing applications tend to privilege visual communication (images, text), deploying no or inadequate audio components. This ‘sonic gap’ often means missing out on sonic aspects that are crucial f",{"id":324,"funder":7,"programme":8,"title":325,"piName":10,"institution":108,"country":12,"year":13,"amount":14,"abstract":326},"cordis-european-research-council-award-101082240","Virtual reality emotion training tool","The ERC starting grant project CoPAN (804582) is an innovative, interdisciplinary cross-boundary project. In the project, we study the function, underlying neurophysiological mechanisms, development and evolution of emotional expressions, which has shown us that emotions play a pivotal role in daily life in humans and great apes alike. We also show that emotional expressions in real life are more complex than the acted expressions used in emotion research or applications. I here propose to build",{"id":328,"funder":7,"programme":8,"title":329,"piName":10,"institution":330,"country":43,"year":13,"amount":14,"abstract":331},"cordis-european-research-council-award-101113226","Feel-through Haptic Feedback for Augmented and Virtual Reality","UNIVERSITAT DES SAARLANDES","Virtual and Augmented Reality (VR and AR), often summarized as Extended Reality (XR), is moving from a niche product to a mainstream market. Due to recent advances in wearable sensing and display technologies, powerful VR and AR headsets are commercially available, even for the general public, and promise to become even more miniaturized and cheaper in the coming years. A myriad of important application cases, ranging from gaming or shopping to immersive design and engineering or to tele-surgery",{"id":333,"funder":7,"programme":8,"title":334,"piName":10,"institution":241,"country":242,"year":13,"amount":14,"abstract":335},"cordis-european-research-council-award-101082183","Pre-commercialization of new generation Atomic-layer-deposited Lasers for future green high-performance data centers","The continuous growth of global data traffic pushes the data center technology boundaries and their energy consumption. Data centers already use more than 2% of the global electricity and are expected to consume 20% by 2025. The new generation hyperscale data centers offer a more energy-efficient alternative to conventional data centers but are limited by the current technology restrictions. Silicon photonics has been deemed to solve current bottlenecks for building green hyperscale data centers",{"id":337,"funder":7,"programme":8,"title":338,"piName":10,"institution":339,"country":20,"year":13,"amount":14,"abstract":340},"cordis-european-research-council-award-101113529","Terahertz graphene receiver for wireless communications","FUNDACIO INSTITUT DE CIENCIES FOTONIQUES","6th generation (6G) mobile broadband communications will transform the communications industry, leading to high speed networks capable of linking integrated communication, sensing, and computing capabilities to fuse the physical, biological, and cyber worlds. However, 6G infrastructure will require a significant increase in data transfer rate (>10 times larger than current standards), ultra-low power consumption (\u003C1pj\u002Fbit), and high reliability. 5G technology, originally designed for data rates ",{"id":342,"funder":7,"programme":8,"title":343,"piName":10,"institution":344,"country":20,"year":13,"amount":14,"abstract":345},"cordis-european-research-council-award-101112898","Scalable Graphene-enabled ElectroChemical Treatment for Complete Destruction of “Forever Chemicals” in Contaminated Water","FUNDACIO INSTITUT CATALA DE RECERCA DE L'AIGUA","Poly- and perfluoroalkyl substances (PFAS) have been used since the 1940s and are known as “forever chemicals” due to their extreme persistency to advanced (waste)water treatment strategies. Due to the strength of the C-F bond, each released molecule of PFAS remains in the environment. Today there are more than 9,000 known PFAS, majority of them being extremely resistant to any kind of degradation, and with high bioaccumulation potentials and toxicities. Electrochemical processes can address the",{"id":347,"funder":7,"programme":8,"title":348,"piName":10,"institution":154,"country":12,"year":13,"amount":14,"abstract":349},"cordis-european-research-council-award-101101022","Detection and identification of nanoplastics in water via plasmonic-based spectrometric methods using evaporation-driven colloidal assembly","In recent years, we have discovered that our environment is extensively polluted with plastic particles in a wide range of sizes, from the largest pieces that we can identify with our bare eyes, to the so called “microplastics” (\u003C 5 mm).  As a consequence of the improvement in detection techniques, we now know that, for example, up to trillions of microplastic particles per litre have been found in plastic bottles for infants and in general plastic-based consumer water containers. Plastic debris",{"id":351,"funder":7,"programme":8,"title":352,"piName":10,"institution":353,"country":354,"year":13,"amount":14,"abstract":355},"cordis-european-research-council-award-101082300","Precision tissue biobanking made easy","NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU","NO","Large scale biobanks are essential to meet the world-wide demand for high quality tissues to understand the development and progression of disease, or discover and validate novel biomarkers. Current biobanking protocols for harvesting and processing tissue are manual and therefore rely on experienced and costly on-site personnel. Imagine the possibilities of scientific discoveries in personalized diagnostics, prognostics and treatment if high-quality tissues could be made available from several ",{"id":357,"funder":7,"programme":8,"title":358,"piName":10,"institution":359,"country":97,"year":13,"amount":14,"abstract":360},"cordis-european-research-council-award-101101031","Cache-aided Folding for Reducing VoD Loads in Networks","EURECOM GIE","Communicating video-on-demand (VoD) over various networks is very costly. VoD drives up the costs for purchasing bandwidth and overprovisioning infrastructures, as well as the costs to content providers (Netflix, Amazon, etc.) that must pay large fees to network operators to deliver content to their clients. To reduce the massive VoD fees, networks employ caches. Our findings in our ERC project DUALITY reveal a new method of exploiting caches that boosts the performance of various networks. We w",{"id":362,"funder":7,"programme":8,"title":363,"piName":10,"institution":364,"country":365,"year":13,"amount":14,"abstract":366},"cordis-european-research-council-award-101113328","Human skeletal muscle platform for disease modelling and high-throughput drug screening","FUNDACAO GIMM - GULBENKIAN INSTITUTE FOR MOLECULAR MEDICINE","PT","Neuromuscular disorders (NMDs) are a collection of pathologies that affect the skeletal muscle (SkM) function and lead to reduced mobility, breathing issues and death. Most NMDs are incurable and existing therapies are generally ineffective. The major contributor for the lack of NMD therapies is the absence of human NMD research models, applicable for the screening and validation of therapeutic candidates. Our goal for this project is to develop an in vitro platform containing highly biomimetic ",{"id":368,"funder":7,"programme":8,"title":369,"piName":10,"institution":154,"country":12,"year":13,"amount":14,"abstract":370},"cordis-european-research-council-award-101113279","SMARTSENS: Smart wear for sensing the neuromusculoskeletal system during human movement in vivo","Neurological injuries such as stroke or spinal cord injury, leave 5 million people disabled worldwide annually, drastically impairing individuals' ability to move independently. The main element hampering efficacy of current neuro-rehabilitation procedures is the inability of sensing the activity of neural cells involved in the control of movement, along with the movement-generating mechanical force produced by innervated muscle-tendon units, in the intact moving human in vivo. Current technolog",{"id":372,"funder":7,"programme":8,"title":373,"piName":10,"institution":374,"country":103,"year":13,"amount":14,"abstract":375},"cordis-european-research-council-award-101113365","Cost-Effective Charge-Transport Materials for New-Generation Solar Cells","LINKOPINGS UNIVERSITET","The European Union adopted an ambitious and much-needed European Green Deal policy to make Europe the world's first climate-neutral continent by 2050. Harvesting solar energy from photovoltaics (PVs) is a promising way to tackle today’s energy issues and to contribute to the European Green Deal. New-generation PV technologies (such as those based on organic semiconductors and metal halide perovskites) offer many benefits compared to traditional silicon-based solar panels in terms of lightweight,",{"id":377,"funder":7,"programme":8,"title":378,"piName":10,"institution":379,"country":20,"year":13,"amount":14,"abstract":380},"cordis-european-research-council-award-101113106","Titanium-organic framework membranes for CO2 capture","UNIVERSITAT DE VALENCIA","The continued growth in emissions of greenhouse gases in the atmosphere is a pressing issue for our society. The urgent need for strategies to reduce greenhouses gas concentrations has aroused international action from governments. Carbon capture and storage technologies (CCS) have been considered a key solution to reverse the current CO2 trend because they can mitigate, or at least delay, the alarming greenhouses effects. However, the most effective solution for post-combustion CO2 remains stil",{"id":382,"funder":7,"programme":8,"title":383,"piName":10,"institution":379,"country":20,"year":13,"amount":14,"abstract":384},"cordis-european-research-council-award-101101079","Anion Exchange Membrane Water stack based on Earth Abundant 2D Materials for Green Hydrogen Production","The baseline technology for green H2 production is the water-electrolysis (WE). However, roughly 96% of the H2 produced today is from fossil fuels, with the remaining 4% produced through water electrolysis , due to the still-high costs, and lower performance of current electrolysers compared with other production processes not affected by the use of toxic or critical raw materials (CRM). Therefore, there is a need of boosting the development of highly active and efficient catalysts to turn green",{"id":386,"funder":7,"programme":8,"title":387,"piName":10,"institution":48,"country":31,"year":13,"amount":14,"abstract":388},"cordis-european-research-council-award-101101051","Phototherapy treatment for long-term COVID-19 patients","As the number of COVID-19 cases grows worldwide, so does the number of those suffering from clinical parameters that last weeks to-months post initial recovery, termed long-COVID, with as much as 36.55% of survivors exhibiting long-lasting symptoms (e.g., weight loss, chest pain, cognitive and memory disorders, breathlessness) according to recent studies—an estimated ~157 million long-COVID adult patients worldwide to date. Clearly, this growing health problem represents a modern global medical ",{"id":390,"funder":7,"programme":8,"title":391,"piName":10,"institution":392,"country":149,"year":13,"amount":14,"abstract":393},"cordis-european-research-council-award-101113343","Versatile optical frequency comb","UNIVERSITE LIBRE DE BRUXELLES","Frequency combs are optical sources that can be used as rulers. Any unknown frequency can be very precisely measured by comparing it to the nearest tooth of the comb. The technology has revolutionized metrology and spectroscopy among others and its inventors were awarded the Nobel Prize in 2005.To obtain a frequency comb, a periodic optical pattern must be generated. There are different ways of forming optical patterns and different technologies are used, depending on the required comb spacing (",{"id":395,"funder":7,"programme":8,"title":396,"piName":10,"institution":196,"country":43,"year":13,"amount":14,"abstract":397},"cordis-european-research-council-award-101100870","Responsive classifiers against hate speech in low-resource settings","Hate speech is a worldwide phenomenon that is increasingly pervading online spaces, creating an unsafe environment for users. While tech companies address this problem by server-side filtering using machine learning models trained on large datasets, these automatic methods cannot be applied to most languages due to lack of available training data.Based on recent results of the PI's ERC project on multilingual representation models in low-resource settings, Respond2Hate aims at developing a pilot",{"id":399,"funder":7,"programme":8,"title":400,"piName":10,"institution":379,"country":20,"year":13,"amount":14,"abstract":401},"cordis-european-research-council-award-101101025","Dry-processing of metal halide perovskites into thin films","Perovskite semiconductors are promising for photovoltaics with a potentially very large market. Industrial compatible deposition processes that do not employ solvents are unavailable currently. We have developed a new deposition process, that is completely solvent free, compatible with a wide range of perovskite precursors, operates at moderate vacuum levels and leads to high quality films with crystal grains in the order of 500 nm. In the APERITIF project we aim to attract industrial sponsors, ",{"id":403,"funder":7,"programme":8,"title":404,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":405},"cordis-european-research-council-award-101113441","Hybrid Imaging in the Catheterization Room","Hybrid Imaging in the Catheterization Room In the previously-completed ERC CoG, we have developed a patented c-arm scanner (called IXSI) which can accomplish real-time hybrid image guidance in dynamic environments such as the intervention and the catheterization room. Thus far, we have evaluated IXSI for oncological purposes. But more recently, we have identified a new potential application in the field of interventional cardiology, in which hybrid imaging may help for determining the culprit ve",{"id":407,"funder":7,"programme":8,"title":408,"piName":10,"institution":409,"country":20,"year":13,"amount":14,"abstract":410},"cordis-european-research-council-award-101101053","Measuring Illegal Online Pharmacies' Impact and Co-evolution","INSTITUTO DE EMPRESA SL","The pharma analytics market reached $60B in revenues in 2021 and is expected to grow at a 20% annual rate in the coming years. The data and business intelligence provided by pharma analytics companies around drug sales is of outmost importance for multiple stakeholders in the pharma industry (e.g., manufacturers, distributors, and regulators), who rely on this data for their decision-making. However, this data is becoming increasingly biased and myopic: it only accounts for drug sales from legal",{"id":412,"funder":7,"programme":8,"title":413,"piName":10,"institution":30,"country":31,"year":13,"amount":14,"abstract":414},"cordis-european-research-council-award-101082135","Novel functionalization of liposomic nano-vehicles for strongly-enhanced drug delivery","Delivery to diseased cells or tissues of therapeutic agents attached or encapsulated in nanoparticles – nanomedicine - presents many benefits, and comprises a rapidly-growing multi-billion-euro market. Lipid-based drug-delivery nano-vehicles, where drugs (not least the recent, very-widely-used, mRNA-based COVID-19 vaccines) are encapsulated in lipid vesicles (liposomes) or lipid nanoparticles, form a substantial part of that market. Nearly all FDA-approved liposomic vehicles are functionalized w",{"id":416,"funder":7,"programme":8,"title":417,"piName":10,"institution":418,"country":20,"year":13,"amount":14,"abstract":419},"cordis-european-research-council-award-101082338","Development of a marketable adjuvant candidate for vaccine applications","ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS","ADJUVACCINE seeks to leverage a breakthrough made in the ERC-2016-STG-716878 project to validate a synthetic technological platform for the scalable production of identified optimised saponin adjuvants for improved cost-effective vaccines. We have developed in the laboratory potent, safe, stable, and streamlined adjuvant leads that surpass the QS-21 natural product adjuvant, leading to patent applications and the interest of Pharma. In this PoC project, we aim to exploit our synthetic saponin te",{"id":421,"funder":7,"programme":8,"title":422,"piName":10,"institution":211,"country":37,"year":13,"amount":14,"abstract":423},"cordis-european-research-council-award-101113345","Protect Your Peerless Artwork with Innovative Nanoengineered Technology","The art market has always had to deal with an endemic problem: counterfeiting. All art is historically at risk of being copied and sold fraudulently by counterfeiters. A report by the Swiss Fine Art Expert Institute estimates that over half of all the artwork in circulation is fake. All this creates an incalculable loss of value for the entire market, including artists, auction houses, insurance companies and of course the end buyers, who often find themselves spending considerable sums of money",{"id":425,"funder":7,"programme":8,"title":426,"piName":10,"institution":427,"country":354,"year":13,"amount":14,"abstract":428},"cordis-european-research-council-award-101101037","Towards Operational Supermodel Climate Prediction","UNIVERSITETET I BERGEN","TOSCP will proof-of-concept a radically new approach to climate prediction based on supermodelling. Climate prediction promises reliable information on climate and its extremes for the coming seasons and years. This information is critical to providing climate services that are needed to build a resilient and sustainable society. Unfortunately, predicting climate in the extra-tropics remains a major challenge. Model systematic error is the major limitation. In the North Atlantic-European sector ",{"id":430,"funder":7,"programme":8,"title":431,"piName":10,"institution":432,"country":31,"year":13,"amount":14,"abstract":433},"cordis-european-research-council-award-101082166","FibRestoration - Novel specialized probiotics for restoring a healthy  fiber-degrading microbiome","BEN-GURION UNIVERSITY OF THE NEGEV","Dietary fiber is well-recognized as beneficial to gut microbiome and has repercussions on human health. Consequently, in recent years, alternative dietary lifestyles favoring the consumption of high amounts of dietary fibers have been proposed. In order to avoiddigestive discomfort associated with the increased intake of dietary fiber, we propose to develop probiotics that will target cellulose, the main component of dietary fiber. Indeed, cellulose-degrading bacteria are absent both in gut micr",{"id":435,"funder":7,"programme":8,"title":436,"piName":10,"institution":437,"country":43,"year":13,"amount":14,"abstract":438},"cordis-european-research-council-award-101113400","Deep Learning Air Quality Forecasts for Four Days","FORSCHUNGSZENTRUM JULICH GMBH","AQplus4 will develop the first scientifically sound operational air quality forecasting system based on innovative deep learning and IT technology. Based on the successful development of AI air quality forecasting models in the IntelliAQ advanced grant, we will explore the combination of several deep learning models into one coherent concept, test the transferability to new air pollutant species and other world regions. Furthermore, the grant shall cover the necessary technical developments to p",{"id":440,"funder":7,"programme":8,"title":441,"piName":10,"institution":36,"country":37,"year":13,"amount":14,"abstract":442},"cordis-european-research-council-award-101081539","Advanced 3D in vitro models based on magnetically-driven docking of modular microscaffolds","This project is focused on the design, the production, the characterization, and the proposal for future commercialization of 3D modular co-culture systems, specifically designed to recapitulate the physio-pathological microenvironment of brain tumor. The key technology at the base of the proposed project is the design of magnetic microscaffolds and their fabrication through two-photon polymerization (2pp), a disruptive mesoscale manufacturing technique that enables low-cost obtainment of micros",{"id":444,"funder":7,"programme":8,"title":445,"piName":10,"institution":446,"country":43,"year":13,"amount":14,"abstract":447},"cordis-european-research-council-award-101113349","Antibiotic Lead Optimization","HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH","The bacterial sliding clamp (DnaN) is an innovative target for the development of novel antibiotics, which are urgently needed to overcome the alarming antimicrobial resistance crisis. In the previous ERC starting grant (NovAnI), we discovered a novel DnaN inhibitor (WAM-N17) with promising broad-spectrum antibacterial activity including multidrug-resistant (MDR) pathogens. In this PoC project, we will optimize the antibacterial potency and spectrum and characterize the in vivo pharmacokinetic (",{"id":449,"funder":7,"programme":8,"title":450,"piName":10,"institution":451,"country":97,"year":13,"amount":14,"abstract":452},"cordis-european-research-council-award-101100924","All-in-one supramolecular approach as an innovative anti-infectious strategy","UNIVERSITE GRENOBLE ALPES","Despite the large therapeutic arsenal available to fight bacterial infections, the development of new anti-infectious strategies is a major public health concern. Pathogens have indeed developed a variety of Multi Drug Resistance mechanisms to escape destruction. To circuvment these problems, a few promising alternatives have been proposed. A first one focuses on the bacterial adhesion step to the host cells which involves multivalent interactions between the glycocalix and bacterial adhesins. M",{"id":454,"funder":7,"programme":8,"title":455,"piName":10,"institution":456,"country":242,"year":13,"amount":14,"abstract":457},"cordis-european-research-council-award-101112887","Time Keeping with Epsilon-Near-Zero Metamaterials","TAMPEREEN KORKEAKOULUSAATIO SR","Accurate time interval measurement and synchronization between two or more pulses are highly desirable in different fields of science and technology. Electronic components-based approaches can not measure the time difference between two events precisely below two-digit picosecond scale. Additionally, the use of highly expensive electronic components and temperature increase due to the heat generated within the system are other drawbacks, limiting its long-term use and performance. To address the",{"id":459,"funder":7,"programme":8,"title":460,"piName":10,"institution":461,"country":43,"year":13,"amount":14,"abstract":462},"cordis-european-research-council-award-101113481","An automated platform for the large-scale production of miniaturized neuromuscular organoids","MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)","Organoids have been developed as advanced 3D cell culture systems that resemble aspects of the in vivo tissues and provide an alternative to study the mechanisms of human disease and identify novel treatments. The last years have witnessed tremendous developments in the field of stem cell and organoid research, but the full potential of these systems remains to be exploited. Two major challenges facing the organoid field are reproducibility and scalability. The manual production of organoids is ",{"id":464,"funder":7,"programme":8,"title":465,"piName":10,"institution":67,"country":31,"year":13,"amount":14,"abstract":466},"cordis-european-research-council-award-101081911","Diffractive Optical Element Fabrication based on 3D Printing","Diffractive Optical Elements (DOEs) are used to shape the wavefront of incident light in complex patterns, and are ubiquitous across optical applications, ranging from laser processing through lithography to communication and imaging. Despite their popularity, fabricating DOEs is non-trivial, mostly due to their nanoscale-precision requirements, necessitating highly precise, expensive and cumbersome fabrication methods (typically using photolithography), which are also limited in the design flex",{"id":468,"funder":7,"programme":8,"title":469,"piName":10,"institution":67,"country":31,"year":13,"amount":14,"abstract":470},"cordis-european-research-council-award-101113408","Synthetic Cells for Functional Food Platforms","Global food shortage together with economical stress poses a nutritional threat to various populations. For elders, food shortage affects health and well-being and is directly associated with immune and neurological deficiencies. Synthetic cells (SC) – lipid-based vesicles composed of essential fatty acids and loaded with immune-supporting vitamins and nutrients have been suggested as economical nutritional supplements that can be produced at large-scale and integrated into generic food matrices",{"id":472,"funder":7,"programme":8,"title":473,"piName":10,"institution":211,"country":37,"year":13,"amount":14,"abstract":474},"cordis-european-research-council-award-101113125","PRoduction of an innOvative Millifluidic dEvice for TEsting of new prObiotics","Over the last decades, the gut intestinal microflora and other microbial communities present in our body raised a strong interest in the health research domain as it was discovered their possible relation to the pathophysiology of major organs and systems. Gut epithelial cells, together with our resident microbiota, are involved in the modulation of the host immune system and represent the first line of adsorption of drugs and nutraceuticals. In parallel to microbiota studies, a great effort has",{"id":476,"funder":7,"programme":8,"title":477,"piName":10,"institution":30,"country":31,"year":13,"amount":14,"abstract":478},"cordis-european-research-council-award-101111915","Generating mRNA-HNF4a-Lipid nanoparticles for curing pancreatic cancer-associated cachexia (CAC) in identified patients at risk","Cancer-associated cachexia (CAC) is a multifactorial syndrome causing significant morbidity and mortality in cancer patients and indicates a poor prognosis. Nearly 80% of cancer patients experience CAC, which directly accounts for almost 20% of all cancer deaths, mainly in patients with pancreatic adenocarcinoma (PDAC). Clinically, CAC manifests as weight loss and wasting of skeletal muscle mass. Thus, CAC patients experience reduced physical, emotional, and social well-being, leading to increas",{"id":480,"funder":7,"programme":8,"title":481,"piName":10,"institution":482,"country":37,"year":13,"amount":14,"abstract":483},"cordis-european-research-council-award-101113229","Targeting telomeric DNA damage response as a new strategy to fight immunosenescence and improve vaccine response","IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS","The immune system is remodeled with age, going through a series of changes known as “immunosenescence’, including the involution of primary lymphoid organs, the contraction of the immune repertoire, a progressive lineage skewing towards the myeloid lineage and a low-grade pro-inflammatory status. A consequence of immunosenescence impacting the morbidity and mortality of infectious diseases is a dramatically reduced vaccine response in the elderly. Thus, reducing the burden of immunosenescence ha",{"id":485,"funder":7,"programme":8,"title":486,"piName":10,"institution":487,"country":12,"year":13,"amount":14,"abstract":488},"cordis-european-research-council-award-101112973","Smart RNA delivery for therapy and diagnostic","STICHTING VU","The progression of RNA-based cellular applications in molecular therapy has been greatly hindered due the difficulty of delivering RNA across biological barriers. Interest has therefore grown in the development of carrier systems which can facilitate RNA delivery in a controlled manner. Herein, we use peptide-based, binders to stabilise and deliver double-stranded RNA. The main goals of this project are the identification of lead candidates with robust cell delivery in relevant cell lines, and t",{"id":490,"funder":7,"programme":8,"title":491,"piName":10,"institution":492,"country":149,"year":13,"amount":14,"abstract":493},"cordis-european-research-council-award-101067679","MIRRA: Microclimate Real-time Remote Applications","UNIVERSITEIT GENT","Climate change, and its impacts on ecological, agricultural, and other societal systems, is often studied by relying on temperature data derived from official weather stations. Yet, these data do not capture microclimates, influenced by vegetation, soil and topography, operating at spatial scales relevant to the majority of organisms on Earth. Detecting and attributing climate-change impacts with confidence and certainty will only be possible if we better quantify how temperatures are changing i",{"id":495,"funder":7,"programme":8,"title":496,"piName":10,"institution":497,"country":124,"year":13,"amount":14,"abstract":498},"cordis-european-research-council-award-101082299","EXplainable ALgorithmic Tools","MIM.AI SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA","Deploying algorithmic solutions in real-world applications raises two challenges. First, we need easy-to-use and universal algorithms.Second, we need to guarantee that algorithmic solutions can be understood by people using them. We address the first of thesechallenges in TUgbOAT project, which aims to deliver unified algorithmic tools. Here, we propose to develop tools that would addressthe second of these challenges.In many use scenarios, algorithms propose a solution to a human operator. The ",{"id":500,"funder":7,"programme":8,"title":501,"piName":10,"institution":72,"country":31,"year":13,"amount":14,"abstract":502},"cordis-european-research-council-award-101113120","Fast Matrix Multiplication for AI","Matrix multiplication consumes huge amount of resources: computing time and energy, primarily in AI applications. The industry has recognized the need for faster and more energy-efficient matrix multiplication with state-of-the-art solutions in software (e.g., DGEMM of Intel's math kernel library (MKL) for CPU and NVIDIA's CUDA for GPU) and hardware (e.g., Google's TPU and Intel \u002F Habana labs Gaudi accelerator). Unfortunately, all present solutions employ a wasteful cubic-time algorithm. We have",{"id":504,"funder":7,"programme":8,"title":505,"piName":10,"institution":506,"country":20,"year":13,"amount":14,"abstract":507},"cordis-european-research-council-award-101101098","The Mouse Village: a fully automated behavioral system for continuous social and cognitive testing","FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER","Drug discovery in mental health is undergoing a crisis. Characterizing a new generation of biomarkers for the different disorders seems the promising path towards developing new treatments. Biomarkers, including behavioral biomarkers, are quantitative observables that are altered and can be used for diagnosis, prognosis or treatment response monitoring. Importantly for preclinical research, these biomarkers should be translational and work across species, but experiments in rodents are largely b",{"id":509,"funder":7,"programme":8,"title":510,"piName":10,"institution":154,"country":12,"year":13,"amount":14,"abstract":511},"cordis-european-research-council-award-101069402","WAVESIM – The next generation electromagnetic wave solver","Maxwell solvers are widely used in science and industry for the design and analysis of photonic devices, radio frequency electronics, integrated circuits, antennas, metamaterials, and more. Unfortunately, solving Max-wells equations for complex structures is extremely computationally intensive.In the ERC funded research project DEEP VISION, we discovered a new approach to solve Maxwell's equations much faster (a factor 2000) and more accurate (a factor 10 at least) than conventional methods. In ",{"id":513,"funder":7,"programme":8,"title":514,"piName":10,"institution":515,"country":97,"year":13,"amount":14,"abstract":516},"cordis-european-research-council-award-101113339","Single-Source Collaborative Publishing","UNIVERSITE PARIS-SACLAY","Book publishing involves many stakeholders and a complex set of inflexible tools and formats. Current workflows are inefficient because authors and editors cannot make changes directly to the content once it has been laid out. They are costly because creating different output formats, such as PDF, ePub or HTML requires manual labor. Finally, new requirements such as the European directive on accessibility incur additional costs and delays. The goal of the OnePub POC project is to demonstrate the",{"id":518,"funder":7,"programme":8,"title":519,"piName":10,"institution":520,"country":20,"year":13,"amount":14,"abstract":521},"cordis-european-research-council-award-101100615","efficient Syntactic Analysis for Large-scale Sentiment Analysis","UNIVERSIDADE DA CORUNA","One of the key aspects of any successful business is knowing how customers feel about its brand and products. For this purpose, sentiment analysis or opinion mining tools could be paramount in helping companies to succeed. However, the current state of the art sentiment analysis solutions (both commercial or academic) present important drawbacks including low accuracy, low performance (response time around 100-1000 ms), high computational cost and\u002For high price (around €500\u002Fmonth on average) rel",{"id":523,"funder":7,"programme":8,"title":524,"piName":10,"institution":525,"country":354,"year":13,"amount":14,"abstract":526},"cordis-european-research-council-award-101081935","Feasibility of a multi-panel of epigenetic markers of fish growth","NORD UNIVERSITET","Aquaculture, the process of controlled fish and shellfish cultivation, is a sustainable alternative to fisheries. The sector has seen tremendous growth and Nile tilapia is one of the most important commercially farmed species worldwide. To date, the optimization of production yields is limited to traditional selective breeding programs, that exclusively focus on genetic markers. As a result, unknown variability in growth selection remains, which may be diminished through epigenetic selection.Pro",{"id":528,"funder":7,"programme":8,"title":529,"piName":10,"institution":530,"country":149,"year":13,"amount":14,"abstract":531},"cordis-european-research-council-award-101112780","Targeting Mfrn2 to Inhibit Metastatic Cancers","VIB VZW","Metastasis formation is the leading cause of death in cancer patients. Thus, there is an unmet need for drugs that can prevent and\u002For treat systemic metastases. We have discovered that breast cancer cells rely on a solute carrier (SLC) transporter for metastasis formation in lung and liver. Interestingly, systemic inhibition of this SLC transporter using a therapeutic modality has likely a favorable toxicity profile because knockout mice are viable and have very few and minor phenotypic changes.",{"id":533,"funder":7,"programme":8,"title":534,"piName":10,"institution":48,"country":31,"year":13,"amount":14,"abstract":535},"cordis-european-research-council-award-101113391","Polarized 3D Endoscopy","The proliferation of artificial intelligence (AI) has led to a major advancement in many fields. It has enabled achieving non-precedent achievements such as human-level image recognition, intelligible language translation, and accurate medical diagnosis. The main research goal of the PIs ERC-StG SPADE project is to use tools for data modelling to improve our understanding and usage of deep learning (DL) and thus enhance its performance in medical problems and computational imaging [1-4]. One of ",{"id":537,"funder":7,"programme":8,"title":538,"piName":10,"institution":257,"country":103,"year":13,"amount":14,"abstract":539},"cordis-european-research-council-award-101100663","Novel treatments for the mucus accumulation at chronic lung diseases","The aim of this proof of concept is to develop novel therapies based on the discoveries made during the AdvERC grant on mucus and mucins in the lung and intestine. The discovery that the XX protein is absent or almost absent in healthy individuals and animals and heavily increased in human COPD and induced lung disease in animals made us study this. During the ERC grant we  discoverd that XX is anchoring and attaching the lung mucus by forming a cap on the accumulated mucus. In the absence of  X",{"id":541,"funder":7,"programme":8,"title":542,"piName":10,"institution":118,"country":12,"year":13,"amount":14,"abstract":543},"cordis-european-research-council-award-101113464","Streamlining structural biology: Developing a high-throughput cloud-based cryo-electron tomography platform","Cryo-electron microscopy (cryoEM) has revolutionized biomolecular research. It enables structure determination of proteins and their complexes at near-atomic resolution, informing on their mechanism of action and their role in disease. Importantly, it also assists the development of novel therapeutics. Cryo-electron tomography (cryoET) is an emerging cryoEM modality, which has demonstrated the potential of to determine protein structures at near-atomic resolution in their near-native environment",{"id":545,"funder":7,"programme":8,"title":546,"piName":10,"institution":547,"country":20,"year":13,"amount":14,"abstract":548},"cordis-european-research-council-award-101123039","ADvanced SOILs for the agritech R&D","NEIKER-INSTITUTO VASCO DE INVESTIGACION Y DESARROLLO AGRARIO SA","AdSoils project aims to evaluate, validate, and develop artificial advanced soil technology for its commercial exploitation as a tool forscreening crops from belowground.As part of the Farm to Fork strategy, the European Commission aims at reduced “nutrient losses of at least 50% by 2030, whileensuring no deterioration in soil fertility. This is expected to lead to a reduction in fertiliser use of at least 20%”. The breeding andagrochemical sectors are now seeking ways for crops to acquire water",{"id":550,"funder":7,"programme":8,"title":551,"piName":10,"institution":552,"country":143,"year":13,"amount":14,"abstract":553},"cordis-european-research-council-award-101123379","Exploration of targeting GPR56 and its cancer cell ligand as a novel immune checkpoint inhibition strategy","KOBENHAVNS UNIVERSITET","Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy over the last decade. In essence, ICIs block the interaction of immunosuppressive receptors and their ligands, which attenuate T cell activity and the secretion of pro-inflammatory cytokines. Blocking these inhibitory signals results in the release of immunosuppression and promotes anti-tumor T cell reactivity.Unpublished data from our research group, emerging in collaboration with the biotech company InProTher suggests a nov",{"id":555,"funder":7,"programme":8,"title":556,"piName":10,"institution":557,"country":20,"year":13,"amount":14,"abstract":558},"cordis-european-research-council-award-101138214","VAScularised Tumour Organoids on a chip with human placenta vessels as a preclinical model for anticancer therapies.","UNIVERSIDAD DE ZARAGOZA","VASTO Proof of Concept aims to develop and test an innovative microfluidic-based platform, which allows to evaluate the efficacy of different cell immunotherapy strategies against solid tumours.  For this aim, we propose to microfabricate 3D solid tumour organoids with an aberrant microvascular network provided from the explant of human vessels. Although there are other different vessel-on-a-chip and\u002For microvascular network formation approaches that use in vitro cell monolayers, we are not awar",{"id":560,"funder":7,"programme":8,"title":561,"piName":10,"institution":562,"country":20,"year":13,"amount":14,"abstract":563},"cordis-european-research-council-award-101138458","Piezomagnetic ferrites for self-biased non-reciprocal millimeter wave devices","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","The relentless demand to increase data rates, traffic, and connected devices in our mobile communications has prompted a paradigm shift in wireless technology. 5G and the forthcoming 6G will use mm-waves and miniaturized antenna systems that need to be low-cost and energetically efficient. An unresolved challenge of this transition is the miniaturization of non-reciprocal devices above 100 GHz. Pi4NoRM envisions an on-chip integration of miniaturized self-biased non-reciprocal magnetic component",{"id":565,"funder":7,"programme":8,"title":566,"piName":10,"institution":36,"country":37,"year":13,"amount":14,"abstract":567},"cordis-european-research-council-award-101123231","Privacy-Preserving Security Cameras based on Metalenses","Surveillance cameras are widely used by governments, businesses, and ordinary citizens to monitor private and public areas to deter crime and identify offenders. As of 2021, it was estimated that there are over 1 billion surveillance cameras worldwide.However, there are great concerns that continuous monitoring severely restricts people's privacy and freedom of movement. There have been reports of abuse of surveillance footageincluding by businesses and government institutions. Regulators, civil",{"id":569,"funder":7,"programme":8,"title":570,"piName":10,"institution":571,"country":12,"year":13,"amount":14,"abstract":572},"cordis-european-research-council-award-101123027","Stable and Clean Iron Power from ICONIC","TECHNISCHE UNIVERSITEIT EINDHOVEN","Iron Power is a new technology to store and transport sustainable energy. An iron aerosol mixture is burned in a flame and the heat is used in high temperature processes. The formed iron-oxide powder is collected and transported to places with a surplus of green hydrogen, where it is regenerated back to iron powder. As such, Iron Power is  a very promising CO2-free circular energy carrier of sustainable energy, which has a very high energy density, is easy to handle, safe, environmentally friend",{"id":574,"funder":7,"programme":8,"title":575,"piName":10,"institution":576,"country":191,"year":13,"amount":14,"abstract":577},"cordis-european-research-council-award-101113418","Validation of Magnet-Free Wireless Charging and Communication for Intra-body Devices","MIDDLE EAST TECHNICAL UNIVERSITY","Cochlear implants (CIs), which electrically stimulate the auditory nerve to repair hearing in people with severe-to-profound hearing loss, are used for more than 40 years. However, conventional CIs have major drawbacks, one of which is the use of magnet in the implanted unit of the CI to help perfect alignment of the coils that are used for RF Link between external and implanted units. However, using magnets prevents the CI users from accessing some of the medical treatment and examination metho",{"id":579,"funder":7,"programme":8,"title":580,"piName":10,"institution":211,"country":37,"year":13,"amount":14,"abstract":581},"cordis-european-research-council-award-101068512","Feasibility of a secretome factory to treat paediatric interstitial lung disease","Despite their astonishing clinical success on adults, there are still no mesenchymal stem cell (MSC)-based products approved for paediatric use. Preclinical studies support a potential beneficial role of MSC therapy to prevent progression in diseases called childhood interstitial lung disease (ChILD). However, MSCs still suffer from the cost of culturing and storage facilities and a lack of standardization of cell populations, their quality and quantity, donor-related factors, protocols for isol",{"id":583,"funder":7,"programme":8,"title":584,"piName":10,"institution":585,"country":185,"year":13,"amount":14,"abstract":586},"cordis-european-research-council-award-101113395","Puzzle cell nutshell waste for sustainable material solutions","UNIVERSITAET FUER BODENKULTUR WIEN","In 2025 around 11 billion tonnes of plastic waste will pollute the environment. Therefore, a circular economy with biotransformation and biodegradation of oil-based plastics is as crucial as implementing biobased and biodegradable materials. Transforming lignocellulosic waste biomass into commercially valuable green materials is an emerging and promising way to minimize waste, substitute plastic and reduce our carbon footprint. As a waste resource, we suggest walnut shells, in which we discovere",{"id":588,"funder":7,"programme":8,"title":589,"piName":10,"institution":590,"country":43,"year":13,"amount":14,"abstract":591},"cordis-european-research-council-award-101100859","Custom-Made Designer Macrophages to Revolutionize the Safety of Parenteral Drugs","MEDIZINISCHE HOCHSCHULE HANNOVER","The iPYRO proposal is built upon the uniqueness of human induced pluripotent stem cells (iPSC) and recent innovations in the farming of fully defined human macrophages (iMonoMac) using industry compatible bioreactors. Given the growing need for industrial macrophages, iPYRO sets an innovation in the forefront of drug safety evaluations, supplying a unique cell type, which meets the expectations from industry and regulators. The breakthrough innovation of iPYRO will offer a superior, thus highly ",{"id":593,"funder":7,"programme":8,"title":594,"piName":10,"institution":206,"country":149,"year":13,"amount":14,"abstract":595},"cordis-european-research-council-award-101138431","Modeling how pre-existing TCR clones affect vaccine-induced T-cell responses","T-cells are increasingly recognized to be pivotal actors in the development of vaccine-induced immune responses. Through their T-cell receptor (TCR) on their cell surface, T-cells can recognize antigens derived from pathogens or vaccines. The strength of the interaction between the TCRs and the vaccine antigens will direct the T-cell dynamics after vaccination. In this project, we will analyse the TCR repertoires from participants from three distinct vaccination cohorts prior to vaccination and ",{"id":597,"funder":7,"programme":8,"title":598,"piName":10,"institution":599,"country":43,"year":13,"amount":14,"abstract":600},"cordis-european-research-council-award-101138549","Targeting kidney fibrosis by a novel myofibroblast specific small molecule inhibitor","UNIVERSITAETSKLINIKUM AACHEN","Chronic kidney disease (CKD) is a progressive disease that is prevalent in 10% of the developed world and develops as a result of diabetes mellitus, hypertension, glomerulonephritis or acute kidney injury. Over time, CKD can progress to end-stage renal disease (ESRD); a condition that can only be treated through hemodialysis or kidney transplantation, posing a severe medical, societal and economic challenge. Fibrosis is recognized as a key pathological mechanism in CKD, responsible for slowly de",{"id":602,"funder":7,"programme":8,"title":603,"piName":10,"institution":196,"country":43,"year":13,"amount":14,"abstract":604},"cordis-european-research-council-award-101100460","Define a lead candidate for clinical development of a novel T cell therapy","Acute myeloid leukemia (AML) is a disease with a poor prognosis, especially for such patients either failing initial treatment or relapsing thereafter. In AML, specific immune cells such as T cells have been proven to bear curative potential in the context of stem cell transplantation but toxicity and therapy failure are frequent. The use of T cells modified for specificity with chimeric antigen receptors (CAR) has changed the landscape of several blood-borne cancer of the B cell lineage. In AML",{"id":606,"funder":7,"programme":8,"title":607,"piName":10,"institution":608,"country":103,"year":13,"amount":14,"abstract":609},"cordis-european-research-council-award-101123215","A novel NASH model for target and drug candidate identification","KAROLINSKA INSTITUTET","NASH is the progressive form of NAFLD that underlies the development of fibrosis, cirrhosis, and hepatocellular carcinoma. The global prevalence of NASH is estimated at 1 billion individuals. NASH is a major cause of death, now the major reason for liver transplantations and the disease is an important cause of hepatocellular cancer (HCC). Currently, there are no FDA-approved drug therapies available. Within the ERC project Hepaspher, a new liver model was developed in which human hepatocytes an",{"id":611,"funder":7,"programme":8,"title":612,"piName":10,"institution":613,"country":365,"year":13,"amount":14,"abstract":614},"cordis-european-research-council-award-101113512","CELLulose nanocomposite separators for the nEXt generation of smart batteries","UNIVERSIDADE NOVA DE LISBOA","As the popularity of electric vehicles continues to increase, so does the number of batteries reaching the end-of-life that are used to power them being expected that by 2030 it will reach 2 million tons worldwide. On top of this the complexity of battery production results in very high scrap rates (about 10%-30%), especially during production ramp-up, while the scarcity of raw materials in Europe are intensifying EU regulations to localize supply chains and safeguard critical raw materials. It ",{"id":616,"funder":7,"programme":8,"title":617,"piName":10,"institution":613,"country":365,"year":13,"amount":14,"abstract":618},"cordis-european-research-council-award-101138403","Improve the shelf life of perishable goods through stabilization of vitamins","Food processing industries face great pressure to increase the shelf life of goods decreasing the tons of waste generated every year. At the same time consumers are becoming more conscious about their choices and more critical about the use of synthetic preservatives. The most common group of chemical compounds used to preserve the freshness of food are vitamins, also known as antioxidants. Antioxidants are compounds capable to inhibit oxidation which is a chemical reaction that leads to the pro",{"id":620,"funder":7,"programme":8,"title":621,"piName":10,"institution":211,"country":37,"year":13,"amount":14,"abstract":622},"cordis-european-research-council-award-101112725","A Computing Unit for Autonomous Spacecraft Guidance in Deep Space","The “space revolution” is expected to become the biggest industry in history. During the last decades, space exploration has contributed to the development of various technologies (e.g., GPS, weather predictions, solar cells, reliable power grid, Earth observation services) that fedback into the economy and improved our lives. In 2020, the global space economy was valued at about $ 446.9 B. With the advent of deep-space CubeSats, nanosatellites that disrupted this industry, space agencies are pl",{"id":624,"funder":7,"programme":8,"title":625,"piName":10,"institution":626,"country":627,"year":13,"amount":14,"abstract":628},"cordis-european-research-council-award-101123353","Implementation of new machine learning algorithms for the optimisation of drug formulations","UNIVERSITE DU LUXEMBOURG","LU","Correctly developing and predicting crystalline forms with specific physico-chemical properties is essential to the pharmaceutical industry. The main challenge this industry faces is the fact that most active pharmaceutical ingredients in most drugs can interconvert into a different (usually more stable) polymorph, potentially reducing the solubility of the drug, slowing down the release of the API and affecting the pharmacokinetics, bioavailability and efficacy of the drug. For instance, due to",{"id":630,"funder":7,"programme":8,"title":631,"piName":10,"institution":632,"country":43,"year":13,"amount":14,"abstract":633},"cordis-european-research-council-award-101122970","Hands-on Materials Science for Education","FORSCHUNGSVERBUND BERLIN EV","Crystalline materials are indispensable to modern life, and the development of crystal growth processes for novel materials remains an important challenge in materials science and engineering. However, the knowledge about these processes is limited to very select, specialist communities. Researchers from different fields often use crystals just as products without being aware of the exciting multi-disciplinary background of their production processes. The HANDSOME project aims to facilitate the ",{"id":635,"funder":7,"programme":8,"title":636,"piName":10,"institution":637,"country":37,"year":13,"amount":14,"abstract":638},"cordis-european-research-council-award-101137970","Creation of a GLP bank of immune-privileged, immortal mesoangioblasts to treat monogenic, recessive diseases of muscle and connective tissue","OSPEDALE SAN RAFFAELE SRL","Stem cells led to effective cures for diseases of blood and epithelia. However, in the case of diseases affecting muscles, connective tissue or brain, significant challenges persist for expansion of a sufficient number of corrected cells, delivery and engraftment. Even when these problems will be solved the prospective per-patient cost of the treatment (up to 2M$) will make such therapies unsustainable for NHS. We developed protocols of cell therapy using mesoangioblasts (Mabs), vessel associate",{"id":640,"funder":7,"programme":8,"title":641,"piName":10,"institution":642,"country":20,"year":13,"amount":14,"abstract":643},"cordis-european-research-council-award-101112853","Therapeutics based on the eAXON technology","UNIVERSIDAD POMPEU FABRA","Within the eAXON project, which is funded by an ERC CoG, we have developed and demonstrated wireless microstimulators whose operation is based on rectification of volume conducted bursts of innocuous high-frequency current externally delivered through textile electrodes. In contrast to previous implantable stimulation technologies apt for clinical use, our technology allows the implementation of much thinner implants that can be minimally invasively deployed by injection. Our prototypes are thre",{"id":645,"funder":7,"programme":8,"title":646,"piName":10,"institution":647,"country":43,"year":13,"amount":14,"abstract":648},"cordis-european-research-council-award-101113433","Waveguide-based Cochlear Implant for Optogenetic Stimulation","UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS","The optical cochlear implant (oCI) aims to restore near natural hearing in profoundly hearing impaired and deaf patients. Sound perception will be restored through an implantable medical device in combination with a gene therapy medicinal product. Thereby the auditory nerve is stimulated directly through focused light replacing the dysfunctional or absent hair cells. This is achieved through combination of micro-scale light emitter technology and precise neural control through expression of ligh",{"id":650,"funder":7,"programme":8,"title":651,"piName":10,"institution":102,"country":103,"year":13,"amount":14,"abstract":652},"cordis-european-research-council-award-101123202","Protein Ruler to Create Affordable Biosensor Diagnosis for the Many","Ovarian cancer is the most common malignancy of the female reproductive system worldwide, and the leading cause of death fromgynecological cancer. However, if diagnosed during the early stages, patients have a good prognosis, at around 90% 5-year survivalrate. Despite its lethality, there are currently no effective simple tests for diagnosis nor population-based screening techniques forovarian cancer. Emerging tests detecting cancer biomarkers have the potential for greatest impact for surveilla",{"id":654,"funder":7,"programme":8,"title":655,"piName":10,"institution":656,"country":12,"year":13,"amount":14,"abstract":657},"cordis-european-research-council-award-101113262","A smart centrifuge camera for testing dewatering ability of waste-water sludges in hyper-gravity","TECHNISCHE UNIVERSITEIT DELFT","The EU produces more than 45000 tons of waste-water sludge per day as byproduct of municipal and industrial water purification activities. This enormous amount can become a gold mine for materials recovery, or an environmental burden, depending on how well waste-treatment plants can remove water from these sludges. Today sludge treatment processes are based on unoptimized methods, which rely on operator experience and low-tech equipment, and are not able to deal with the fast-changing sludge typ",{"id":659,"funder":7,"programme":8,"title":660,"piName":10,"institution":661,"country":185,"year":13,"amount":14,"abstract":662},"cordis-european-research-council-award-101113137","Oral oxytocin for abdominal pain","UNIVERSITAT WIEN","Chronic abdominal pain is a widespread debilitating condition commonly associated with gastrointestinal disorders such as irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). IBS and IBD affect more than 10% of the global population, leaving a severe and steadily growing socio-economic burden on society (€115 billion\u002Fyear in Europe in direct and indirect health care costs). Adequate pain management for these conditions is imperative but remains challenging since classical analge",{"id":664,"funder":7,"programme":8,"title":665,"piName":10,"institution":666,"country":103,"year":13,"amount":14,"abstract":667},"cordis-european-research-council-award-101112727","Impacts of Climate Extremes from Mining of Online Texts","UPPSALA UNIVERSITET","Climate extremes have multifarious detrimental impacts on human activities and ecosystems. Gaining a detailed understanding of these impacts is essential for disaster risk reduction and for building resilience to extremes in a changing climate. However, current freely-accessible natural hazard databases present limitations in completeness, updateability, validation against climate data and indirect impact information. This hinders scientific and practical progress.In ICE-MOT, I aim to build a st",{"id":669,"funder":7,"programme":8,"title":670,"piName":10,"institution":62,"country":12,"year":13,"amount":14,"abstract":671},"cordis-european-research-council-award-101069166","Low-dose breast CT with monochromatic x-ray sources","Although breast cancer screening and improvements in treatment have reduced breast cancer mortality by 30%, this disease still kills over 600,000 women yearly worldwide. To further reduce its morbidity and mortality, new and improved imaging modalities that improve the detection, diagnosis, and treatment of breast cancer are needed.Over the last two decades, changes in x-ray detector technology have revolutionized x-ray-based breast imaging. Among other developments, new digital detectors made f",{"id":673,"funder":7,"programme":8,"title":674,"piName":10,"institution":675,"country":97,"year":13,"amount":14,"abstract":676},"cordis-european-research-council-award-101100599","Nanoscale Integrated Magnetic Field Sensor","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","Magnetic sensors are present everywhere in our daily lives. We often use them in cars, robotics, medical applications, for power sensing, electronic compass, etc. Among them, magnetoresistive sensors play an increasing role thanks to their relatively small size, good sensitivity and low cost. However, magnetoresistive sensors saturate above typically a few milli-Tesla which is too low for a number of applications. Besides, reducing the sensor footprint is important in terms of costs. In addition",{"id":678,"funder":7,"programme":8,"title":679,"piName":10,"institution":680,"country":312,"year":13,"amount":14,"abstract":681},"cordis-european-research-council-award-101113480","Multidimensional in vivo metabolic flux analyses: Resolving immune cells based on in vivo metabolic phenotypes","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","The development of better immunotherapies is being hammered by our lack of understanding about immune cell metabolism in vivo at the sites of disease. We know that immune cell metabolism is pivotal in controlling immune function. For instance, disrupting Natural Killer cell metabolism prevents them from killing cancer cells. Cellular immunotherapies for diseases like solid cancer are underperforming and one central reason for this is the metabolic pressure exerted on immune cells in solid tumour",{"id":683,"funder":7,"programme":8,"title":684,"piName":10,"institution":680,"country":312,"year":13,"amount":14,"abstract":685},"cordis-european-research-council-award-101113332","Evolution of Advanced Luminescent Technology Software","By 2050, the European Union aims to become climate-neutral, developing into an economy with net-zero greenhouse gas emissions. This objective is considered both an urgent challenge (at the heart of the European Green Deal) and an opportunity to improve society . To achieve this ambitious objective, we need to develop and implement new technologies that target the largest energy consumer in the EU: buildings. Collectively, buildings in the EU (homes, workplaces, hospitals, schools) account for 40",{"id":687,"funder":7,"programme":8,"title":688,"piName":10,"institution":689,"country":37,"year":13,"amount":14,"abstract":690},"cordis-european-research-council-award-101113466","Chronic PAIN eradiCAtion by taRgeting Schwann cElls","FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS","About 25% of the adult population experiences chronic pain, which disrupts daily activities and severely affects the patient’s quality of life. In Europe, the socioeconomic burden of chronic pain runs into billions of euros annually and represents 3–10% of the GDP. The current mainstays of pain treatment are non-steroidal anti-inflammatory drugs (NSAIDs) and opioids, but their prolonged use is frequently associated with life-threatening adverse events and physical dependence. There is therefore ",{"id":692,"funder":7,"programme":8,"title":693,"piName":10,"institution":694,"country":354,"year":13,"amount":14,"abstract":695},"cordis-european-research-council-award-101113421","Tool for the Analysis of Information Transfer in Manuscript Cultures","UNIVERSITETET I OSLO","This PoC project aims to alleviate the hesitancy of scholars working on texts preserved in manuscripts or other handwritten media, to adopt advanced digital methodologies in their research, by developing a free, shareable, flexible, low-threshold research tool, which may be used as a starting point for researchers interested in studying the textual transmission of information in manuscript cultures. It will take the form of a pre-designed but flexible data model, data-input framework, and databa",{"id":697,"funder":7,"programme":8,"title":698,"piName":10,"institution":694,"country":354,"year":13,"amount":14,"abstract":699},"cordis-european-research-council-award-101113215","CoFutures Literacy","People around the world imagine futures differently. These imaginations of the future are most clearly found in the fictions they produce (Future Fictions or Speculative Fiction; SF). SF acts as a repository of ideas related to societal change, technological change, climate change, and other kinds of change.  How do we take these different imaginations, and use them to drive societal innovations? How do we work with the complexity of visions around the world, not merely in its richer parts but i",{"id":701,"funder":7,"programme":8,"title":702,"piName":10,"institution":703,"country":97,"year":13,"amount":14,"abstract":704},"cordis-european-research-council-award-101113423","More specific insecticides: harnessing knowledge of insect receptors","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","Pest control is a central component of agriculture. However, insecticides and agriculture can have an impact on ecosystems. Regulations have been taken in Europe to ban some insecticides, based on the possible threat they pose to pollinators. There is an urgent, unmet need for species-specific insecticides that are safe for non-target organisms. In the proposed proof-of-concept project, we aim at demonstrating that peptides specifically designed against neurotransmitter receptors can be potent a",{"id":706,"funder":7,"programme":8,"title":707,"piName":10,"institution":703,"country":97,"year":13,"amount":14,"abstract":708},"cordis-european-research-council-award-101112783","A Digital Twin for Electromobility Flexibility Forecast","As efforts for environmental protection become a major priority, Electric Vehicles (EVs) have started to emerge as one of the main components of sustainable traffic systems in cities worldwide. Indeed, some countries have started to incorporate plans to phase-out conventional vehicles during the next few years with a view to reducing carbon emissions. However, this shift towards an electrified traffic network involves several challenges that need to be met for EVs to become a mainstream feature.",{"id":710,"funder":7,"programme":8,"title":711,"piName":10,"institution":703,"country":97,"year":13,"amount":14,"abstract":712},"cordis-european-research-council-award-101101066","Monitoring of stroke patients with 3D ultrasound localization microscopy","The ERC Cog ResolveStroke has led to the development of a new imaging device, based on super-resolution ultrasound, which can assess ischemic and hemorrhagic stroke through the observation of the smallest blood vessels which are invisible to other medical imaging modalities. This StrokeScanner is currently being demonstrated in a large models before being applied to human studies at the end of the project. Its remarkable results have led to the creation of a startup (Resolve Stroke) which concei",{"id":714,"funder":7,"programme":8,"title":715,"piName":10,"institution":703,"country":97,"year":13,"amount":14,"abstract":716},"cordis-european-research-council-award-101113333","A Metamaterial-based technology to create Electricity from Light","AMELI aims at developing a family of hot carrier devices that operate on a technology discovered by the PI during the course of his ERC-CoG project. This hot carrier technology does not rely on a P-N junction (or one of its many derivatives) to create electricity, giving access to a parameter space that is different from that of traditional solar cells. The goal of AMELI is to assess the potential for disruption of this approach and to propose a first proof of concept photovoltaic (if we can rea",{"id":718,"funder":7,"programme":8,"title":719,"piName":10,"institution":703,"country":97,"year":13,"amount":14,"abstract":720},"cordis-european-research-council-award-101113096","Continuous sub-mK refrigeration by demagnetization of atomic nuclei","The proposed ERC PoC project is to construct the first continuous nuclear demagnetization refrigerator (CNDR). Reaching temperatures near 10 mK has become relatively easy in the last decade. This cryogenic advance has driven an explosion in industrial efforts to build quantum computers based on superconducting qubits as well as rapid progress in fundamental physics experiments around 10 mK. However, cooling condensed matter below 1 mK remains challenging. Furthermore, there is no continuous cool",{"id":722,"funder":7,"programme":8,"title":723,"piName":10,"institution":703,"country":97,"year":13,"amount":14,"abstract":724},"cordis-european-research-council-award-101113273","Ultralow-power logic-in-memory devices based on ferroelectric two-dimensional electron gases","Microelectronics components are at the core of our modern economies. The corresponding global market is exponentially growing at an annual pace of 10-15% and should reach the trillion $ by 2030. The techno-economic framework that has been driving this industry is based on Boolean logic, von Neumann architectures (with separated computing and memory units) and CMOS transistors. It is pictured by the famous Moores law, describing the continuous shrinking of transistor size. For years, Dennards sca",{"id":726,"funder":7,"programme":8,"title":727,"piName":10,"institution":703,"country":97,"year":13,"amount":14,"abstract":728},"cordis-european-research-council-award-101101073","Forwarding development of novel somatosensory testing equipment in humans","The SOMATOSENSE project aims to provide accurate, automated, and innovative tools to probe the human somatosensory afferent system and diagnose problems. Somatosensory information from the skin provides us with a continuous stream of information, to allow us to interact efficiently with the world and to ground us in our bodies. In somatosensory disorders, there can be issues with one or more types of sensory afferent that can cause debilitating effects, including pain. Currently, somatosensory c",{"id":730,"funder":7,"programme":8,"title":731,"piName":10,"institution":732,"country":185,"year":13,"amount":14,"abstract":733},"cordis-european-research-council-award-101113334","Miniaturized Devices for Single-Atom Quantum Technologies","TECHNISCHE UNIVERSITAET WIEN","We propose to realize a new and fully integrated approach for the manipulation of single neutral atoms, which has the potential to transform the complex, room-sized, multi-million-euro experiments currently used to manipulate these atoms in academic laboratories, into user-friendly, economical and robust commercial devices the size of a shoebox. As a proof-of-principle application we propose to realize an integrated single photon source based on a single trapped atom, which has immediate commerc",{"id":735,"funder":7,"programme":8,"title":736,"piName":10,"institution":737,"country":43,"year":13,"amount":14,"abstract":738},"cordis-european-research-council-award-101113551","AI-based leukemia detection  in routine diagnostic blood smear data","HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH","Acute promyelocytic leukemia is an extremely aggressive blood cancer where immediate diagnosis can determine life or death. The diagnostic state of the art is manual inspection of a patient’s blood smear under the microscope by trained cytologists. It is prone to human error and time consuming - a risk factor in notoriously understaffed laboratories. Supporting clinical decisions with AI will drastically increase diagnostic speed and accuracy, benefit patient survival, and free up valuable exper",{"id":740,"funder":7,"programme":8,"title":741,"piName":10,"institution":642,"country":20,"year":13,"amount":14,"abstract":742},"cordis-european-research-council-award-101113382","Boosting trust in online media by instantly informing users about conflicts of interest","Trust in mainstream media has been declining steadily across the world. The trend is fuelled by the perception that news companies are not truly independent but serve the interests of owners, advertisers or creditors. Many media outlets insulate editorial decisions from external pressures, but ordinary citizens have no means to know. Hence, distrust in a few “bad apples” risks extending to the entire industry. The WiseReader project aims to tackle this problem. Based on research carried out unde",{"id":744,"funder":7,"programme":8,"title":745,"piName":10,"institution":562,"country":20,"year":13,"amount":14,"abstract":746},"cordis-european-research-council-award-101100953","Targeted nanohorns for lithium neutron capture therapy","Cancer accounted for nearly 10 million deaths in 2020. Half of all cancer patients are treated with radiation therapy, either alone or combined with other therapeutic modalities (mainly surgery and chemotherapy). One of the first concerns related to radiotherapy is the toxicity of healthy organs and tissues close to the tumour. It is well-known that radiation therapy not only kills cancerous cells that divide, but also affects to the cells in division in healthy tissue. Neutron capture therapy (",{"id":748,"funder":7,"programme":8,"title":749,"piName":10,"institution":562,"country":20,"year":13,"amount":14,"abstract":750},"cordis-european-research-council-award-101113407","self-PoweRed cONductimeter for digiTalization of rapid mOlecular diagnostics","Despite huge progress in prevention and treatment over the past century, infectious diseases still impose a great health burden. For this reason, lab-centralised immunoassays and nucleic acid tests that allow for specific pathogen identification with limits of detection reaching few copies per ml of sample are readily available and supported by both national and private health systems in the developed world. However, these tests are neither affordable nor accessible to patients in low- and mediu",{"id":752,"funder":7,"programme":8,"title":753,"piName":10,"institution":562,"country":20,"year":13,"amount":14,"abstract":754},"cordis-european-research-council-award-101100819","The cold-chain challenge: à la carte Time-temperature indicators enabled by patterned structural colour in organic semiconductors","The global demand for cold-chain logistics is surging, driven by changing consumer lifestyles, government legislations to reduce waste and rapid diversification of supply chains. The pressure is particularly felt in the pharmaceutical and medical industries, where many life-saving products such as vaccines, peptides, blood and plasma explicitly require shipping and handling at specific temperatures. The use of time-temperature indicators to provide visual cues for undesirable exposure to elevate",{"id":756,"funder":7,"programme":8,"title":757,"piName":10,"institution":562,"country":20,"year":13,"amount":14,"abstract":758},"cordis-european-research-council-award-101112847","Regional Economy \u002F Travel Expectations","The assessment of the economic health of economies around the world has historically been based on reports prepared by multiple public and private institutions – from banks to governments. These describe how an economy has evolved in the past, but are lagging and low-resolution pictures of fast evolving systems, and are therefore hill-suited for guiding real decision-making processes under uncertainty. The solution could come from air transport and its demand, as these can provide real-time indi",{"id":760,"funder":7,"programme":8,"title":761,"piName":10,"institution":562,"country":20,"year":13,"amount":14,"abstract":762},"cordis-european-research-council-award-101113523","Carbon dioxide (CO2) Storage In deep volcaNic areas","CO2SINk aims at proving the effectiveness of an innovative CO2 storage concept in deep volcanic areas that reduces the leakage risk. Humans need to take urgent action to achieve a climate-neutral society. Among the necessary actions, Carbon Capture and Storage (CCS) will enable decarbonizing the hard-to-abate industry, which represents some 10% of the current CO2 emissions and can even provide net-carbon removal if it is combined with bioenergy (BECCS) or direct air capture (DACCS). To effective",{"id":764,"funder":7,"programme":8,"title":765,"piName":10,"institution":766,"country":97,"year":13,"amount":14,"abstract":767},"cordis-european-research-council-award-101082059","Miniature Trace Gas Analyzers with FFP microcavities","SORBONNE UNIVERSITE","Fiber Fabry-Perot (FFP) microcavity technology developed in the ERC project EQUEMI enables hand-held gas analyzers based on cavity-enhanced laser spectroscopy with a combination of small size and high performance that does not exist in any commercial instrument today. Furthermore, the FFP principle also enables fiber-coupled arrays of cost-effective, passive remote sensors read out by one central unit using scalable fiber multiplexing technology developed for the telecom market. Both features en",{"id":769,"funder":7,"programme":8,"title":770,"piName":10,"institution":771,"country":97,"year":13,"amount":14,"abstract":772},"cordis-european-research-council-award-101113154","Senolytics repurposing in childhood refractory epilepsies","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","Epilepsy is a frequent neurological disorder characterized by recurrent seizures resulting from hyperexcitability and hypersynchrony of neuronal networks. Cortical malformations, including Focal Cortical Dysplasia (FCD), are rare sporadic diseases that cause early-life drug-resistant seizures for which surgery is the only therapeutic option to control seizures. Surgical inaccessibility and failures are significant clinical drawbacks. This emphasizes a critical and urgent need for new precision-b",{"id":774,"funder":7,"programme":8,"title":775,"piName":10,"institution":771,"country":97,"year":13,"amount":14,"abstract":776},"cordis-european-research-council-award-101111874","Antagonizing GnRH signaling as a “holistic” therapeutic strategy for Polycystic Ovary Syndrome","PCOS is the most common endocrine disorder affecting up to 18% of women worldwide. The syndrome imposes a heavy health burden, covering infertility, obesity, type 2 diabetes and metabolic syndrome. The development of treatment options is an urgent need since there is currently neither a cure nor mechanism-based treatments, leaving patient management suboptimal and focused solely on symptomatic treatment. One key neuroendocrine aberration in most women with PCOS is increased luteinizing hormone (",{"id":778,"funder":7,"programme":8,"title":779,"piName":10,"institution":771,"country":97,"year":13,"amount":14,"abstract":780},"cordis-european-research-council-award-101101006","A completely biological and human tissue-engineered mesh produced from Cell-Assembled extracellular Matrix (CAM) in vitro for the treatment of Pelvic Organ Prolapse (POP)","Pelvic Organ Prolapse (POP) is a major medical issue for women. It is estimated that 1 in 10 women will undergo a surgery to treat POP during her lifetime. To provide mechanical support to the slipping organ, strong and stiff synthetic meshes have been used. Transvaginal meshes are now withdrawn from the market in many countries due to high complication rates. Hence, there is a strong medical and societal need for breakthrough innovations.We propose a new paradigm targeting the fundamental probl",{"id":782,"funder":7,"programme":8,"title":783,"piName":10,"institution":771,"country":97,"year":13,"amount":14,"abstract":784},"cordis-european-research-council-award-101113536","Novel targeted Intervention to Treat Anemia","Anemia, defined as a decreased quantity of circulating red blood cells, is a major source of morbidity and mortality affecting a-third of the worldwide population. As a functional component of erythrocytes hemoglobin, iron is essential for oxygen storage and transport. The liver-derived peptide hepcidin is the master regulator of iron homeostasis. During anemia, the erythroid hormone erythroferrone regulates hepcidin synthesis to ensure the proper supply of iron to the bone marrow for red blood ",{"id":786,"funder":7,"programme":8,"title":787,"piName":10,"institution":771,"country":97,"year":13,"amount":14,"abstract":788},"cordis-european-research-council-award-101113178","Tuneable Conditional Control of Engineered Bacterial Therapeutics","Engineered microbes are attractive platforms for the diagnosis and treatment of several diseases. For example, bacteria can selectively target tumors and are ideal vehicles for in situ delivery of therapeutic agents.However, as of today, no engineered living bacterial therapeutics in clinical trials have the ability for conditional control of therapeutic activity. This lack of reliable control over the timing and dosage of effector molecule production limits the specificity, safety, and efficacy",{"id":790,"funder":7,"programme":8,"title":791,"piName":10,"institution":792,"country":793,"year":13,"amount":14,"abstract":794},"cordis-european-research-council-award-101113474","Cherenkov light for total-body Positron Emission Tomography","INSTITUT JOZEF STEFAN","SI","The paradigm shift in medicine from the treatment of acute or advanced disease to very early diagnosis and even prevention in cancer, as well as in personalized treatment, puts more stringent requirements on positron-emission (PET) imaging both in terms of sensitivity as well as specificity. Novel long axial PET scanners with an axial field of view that can be greater than 1m offer a very attractive solution to many of these challenges, in particular if they are combined with the Time-of-flight ",{"id":796,"funder":7,"programme":8,"title":797,"piName":10,"institution":798,"country":43,"year":13,"amount":14,"abstract":799},"cordis-european-research-council-award-101113091","A prototype system for obtaining and managing training data for multilingual learning","TECHNISCHE UNIVERSITAET MUENCHEN","It is difficult to build high quality machine translation systems for less-resourced languages, such as the minority languages of Europe. State-of-the-art machine translation is trained on large parallel corpora, texts and their translations. But such corpora are not available for less-resourced languages. We will provide a system for the rapid and inexpensive creation of new parallel corpora. Our PoC project will both produce an open-source prototype utilizing findings from the PI's ERC StG, an",{"id":801,"funder":7,"programme":8,"title":802,"piName":10,"institution":798,"country":43,"year":13,"amount":14,"abstract":803},"cordis-european-research-council-award-101101093","EO4FoodSecurity: Using Earth Observation Enabled Land Cover Classification for Characterizing Global Food Security on Regional Scales","Characterizing the state of global food security is essential in devising and evaluating policies and programs for effective decision making. The concept of food security is multidimensional and dynamic and is often compounded by the challenge of obtaining relevant data. Moreover, finding appropriate indicators that specifically encompass the four dimensions of food security (including physical availability of food, economic and physical access to food, food utilization, and sustainability) as s",{"id":805,"funder":7,"programme":8,"title":806,"piName":10,"institution":703,"country":97,"year":13,"amount":14,"abstract":807},"cordis-european-research-council-award-101138132","Smart, Event-Based Microscopy for Cell Biology","Timelapse fluorescence microscopy imaging is routinely used in quantitative cell biology. However, microscopes are passive systems and are still very limited in their operating capacity which limits in several ways our ability to identify and image complex biological events in real time and at the proper 4D scales. They could become much more powerful investigation systems for the life science if they were endowed with user-friendly, unsupervised decision-making algorithms, transforming microsco",{"id":809,"funder":7,"programme":8,"title":810,"piName":10,"institution":339,"country":20,"year":13,"amount":14,"abstract":811},"cordis-european-research-council-award-101123421","POLARSENSE: Polaritonic compact gas sensor demonstrator","Monitoring gases and particles through the use of smart sensors has a crucial role in a wide range of applications, from environmental control to breath analysis for diagnostics. With the information provided by these sensors, we are able to predict, prevent and act in potentially dangerous situations. In order for the data to be effectively transferred, the gas sensors must be integrated into portable devices with wireless connectivity, and must be miniaturized concurrently. To meet this requir",{"id":813,"funder":7,"programme":8,"title":814,"piName":10,"institution":815,"country":20,"year":13,"amount":14,"abstract":816},"cordis-european-research-council-award-101123165","Computational multiplexing to optimise next-generation sequencing","BARCELONA SUPERCOMPUTING CENTER CENTRO NACIONAL DE SUPERCOMPUTACION","Recent advances in Next-Generation Sequencing (NGS) of nucleic acids (i.e. DNA or RNA) have transformed biology and medicine. Today NGS is one of the main pillars of research in various biological disciplines, and it has already pervaded numerous fields of applications ranging from clinics to the biotechnological industry. Given its versatility and high demand, the global market for NGS is rapidly expanding, with the number of sequenced samples doubling every two years. However, while major adva",{"id":818,"funder":7,"programme":8,"title":819,"piName":10,"institution":820,"country":143,"year":13,"amount":14,"abstract":821},"cordis-european-research-council-award-101138121","Development and Mass-dissemination of Intervention to Mobilize Pro-social Bystander Reactions to Hostile Content on Social Media","AARHUS UNIVERSITET","While user-generated content and functionalities that enable users to engage in discussions on social media hold significant democratic potential, online hostility, such as incivility, discrimination and hate speech diminishes the quality of such deliberation. As social media providers are unable to police social media content and be present to moderate discussions effectively, we need to democratize the solution to online hostility by relying more on ordinary citizens who take part in online di",{"id":823,"funder":7,"programme":8,"title":824,"piName":10,"institution":661,"country":185,"year":13,"amount":14,"abstract":825},"cordis-european-research-council-award-101122584","A new paradigm in agrochemistry by manipulating structural bulk","The advent of agriculture has played a decisive role in humankind’s ability to create localized settlements, which has consequently led to the development of complex societies.With increases in human population, the need for reliable large-scale agriculture grew. Sustenance of modern society is a significant societal challenge and relies heavily on two factors: fertilization and crop protection. While the Haber-Bosch process, and related concepts, have contributed to solving the former, crop pro",{"id":827,"funder":7,"programme":8,"title":828,"piName":10,"institution":829,"country":43,"year":13,"amount":14,"abstract":830},"cordis-european-research-council-award-101123144","Nanobodies to prevent hematopoietic stem cell bias and hyper-inflammation.","UNIVERSITATSKLINIKUM BONN","With a growing ageing population, there is an imminent demand to develop new therapeutic strategies to ameliorate disorders of the hematopoietic system. Our innate immune system can remember its previous encounters with inflammatory triggers. Epigenetic memories of previous inflammatory experiences throughout an individual's lifetime are imprinted in hematopoietic stem cells (HSCs), a small pool of bone marrow progenitors that give rise to all our blood cells. Inflammation harms HSCs causing the",{"id":832,"funder":7,"programme":8,"title":833,"piName":10,"institution":118,"country":12,"year":13,"amount":14,"abstract":834},"cordis-european-research-council-award-101123245","The feeling of being there: Developing a practical framework for objective, continuous and standardized presence measurement for virtual environments","Presence is the feeling of being in a virtual environment. It is the concept that provides the most explanatory value to the degree of effectiveness of virtual reality applications. This concept has received an increase in relevancy due to the recent evolution of virtual reality (VR) technology and an increase in attention from the scientific community. Developing new immersive solutions to aid in healthcare, training, entertainment, and research hinges on the ability to objectively measure pres",{"id":836,"funder":7,"programme":8,"title":837,"piName":10,"institution":838,"country":354,"year":13,"amount":14,"abstract":839},"cordis-european-research-council-award-101123485","Sperm filtration for improved success rate of assisted reproduction technology","UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET","ERC starting grant 3D nanoMorph has achieved groundbreaking results that open an unprecedented opportunity for assisted reproduction technologies (ARTs). ARTs require selecting sperms with high fertilization potential - this is characterized by morphology, motility and kinematic parameters of sperms indicating their progressive motility. Current optical solutions for sperm selection can investigate only morphology, nature of motility and kinematics in terms of speed. Our groundbreaking solution ",{"id":841,"funder":7,"programme":8,"title":842,"piName":10,"institution":820,"country":143,"year":13,"amount":14,"abstract":843},"cordis-european-research-council-award-101112763","Vulnerability Exposure Analysis for JavaScript","The JavaScript programming language together with the Node.js framework constitute the foundation of modern web-based software. An essential part of this platform is the npm registry that contains millions of freely available third-party software libraries that provide common functionality. This massive reuse of libraries is essential to the productivity of software developers, however, the dependence on other people's libraries opens the door to security vulnerabilities that may have severe con",{"id":845,"funder":7,"programme":8,"title":846,"piName":10,"institution":847,"country":37,"year":13,"amount":14,"abstract":848},"cordis-european-research-council-award-101123370","biomimetic engineered chordae tendineae for valve repair and regeneration","FONDAZIONE RI.MED","The human heart is among those organs suffering from a limited capacity to self-regenerate. Heart diseases continue to be a leading cause of mortality with suboptimal therapeutic options. Thus, deploying new therapeutic strategies for tissue repair is a primary objective in modern cardiac medicine. Valvular heart diseases, such as those related to the Mitral Valve (MV), are the leading causes of cardiovascular morbidity and mortality worldwide, affecting 5.1% of the 65+ years old population. In ",{"id":850,"funder":7,"programme":8,"title":851,"piName":10,"institution":852,"country":43,"year":13,"amount":14,"abstract":853},"cordis-european-research-council-award-101123031","AI Organoid Image Analysis","LEIBNIZ-INSTITUT FUR VIROLOGIE","Organoids are microscopically small patient-derived 3D organs that can be cultivated in the laboratory over months mimicking human organs and their functions in vitro. These mini-organs have a human genetic background, maintain disease traits in vitro and are currently available for almost every human organ. Due to these advantages, organoid research and its commercial applications are rapidly evolving and increasingly used. Given the high variability of these complex 3D structures, classical ce",{"id":855,"funder":7,"programme":8,"title":856,"piName":10,"institution":637,"country":37,"year":13,"amount":14,"abstract":857},"cordis-european-research-council-award-101138728","Spirocyclic CAMs as novel and ultrapotent anti-HBV drugs (S-CAM)","This PoC project aims to advance the development of next-generation direct-acting antivirals (DAAs) against hepatitis B virus (HBV), namely capsid assembly modulators (CAMs) with a novel spirocyclic scaffold chemotype described in our proprietary patent (WO2021\u002F160617). The identification of next-generation spirocyclic CAMs (S-CAMs) during the funding period of ERC CoG 725038 (FATE) represents a potentially important step towards the cure of chronic HBV infection, one of the major uncontrolled m",{"id":859,"funder":7,"programme":8,"title":860,"piName":10,"institution":552,"country":143,"year":13,"amount":14,"abstract":861},"cordis-european-research-council-award-101123183","Validation of a new drug target in non-alcoholic steatohepatitis","This research focuses on the increasing prevalence of metabolic liver disease, specifically non-alcoholic steatohepatitis (NASH), which is driven by obesity, diabetes, and its related causal connections. NASH is a significant medical challenge with no approved treatments, causing a substantial economic burden. The project aims to investigate the role of oxidative stress in NASH development and progression. By targeting the MAP kinases p38 and JNK, which drive the inflammatory and fibrotic aspect",{"id":863,"funder":7,"programme":8,"title":864,"piName":10,"institution":30,"country":31,"year":13,"amount":14,"abstract":865},"cordis-european-research-council-award-101123436","Developing the next generation of cis-targeting macrophage-T cell cancer immunotherapies","Immunotherapy holds great promise for the curative treatment of millions of cancer patients, with a market size of over 100 billion USD today, which is expected to at least double in the next decade. Cancer immunotherapies are designed either to promote anti-tumor immune activity in the tumor microenvironment (TME), via molecules such as cytokines and antibodies, or to inhibit negative T cell signals induced by cancer and antigen-presenting cells (APCs) in the TME, an approach known as immune ch",{"id":867,"funder":7,"programme":8,"title":868,"piName":10,"institution":869,"country":43,"year":13,"amount":14,"abstract":870},"cordis-european-research-council-award-101123525","Gradient Clock Synchronization for Networks-on-Chip and Cellular Networks","CISPA - HELMHOLTZ-ZENTRUM FUR INFORMATIONSSICHERHEIT GGMBH","In large distributed computing systems there is a big performance advantage when all communication can be carried out synchronously.Current synchronization techniques result in long communication latencies as the systems scale up in size and operating frequency. We identify two key application areas in which this is an immediate and pressing challenge.1. Large Networks-on-Chip (NoCs) do not operate synchronously, despite the relative ease of design and low-latency communication this would offer.",{"id":872,"funder":7,"programme":8,"title":873,"piName":10,"institution":874,"country":37,"year":13,"amount":14,"abstract":875},"cordis-european-research-council-award-101123230","Personalized prognosis in smoldering myeloma through automated analysis of mutational signatures","UNIVERSITA DEGLI STUDI DI MILANO","Multiple myeloma (MM) is the second most common haematological cancer which is symptomless until the later stages, with few treatment options and poor long-term prognoses. Next-generation DNA sequencing (NGS) has been used to identify and characterise the process of clonal evolution and disease progression in asymptomatic MM, however, there remains no viable prognostic NGS method which can be used by clinicians to leverage different mutations to predict progression. The scientific literature ind",{"id":877,"funder":7,"programme":8,"title":878,"piName":10,"institution":879,"country":31,"year":13,"amount":14,"abstract":880},"cordis-european-research-council-award-101123434","An innovative touch-sound technology to provide 360-degree spatial location and content","REICHMAN UNIVERSITY","Digital interfaces & virtual reality (VR) are expected to penetrate more and more aspects of our everyday lives, from the domain of education, to entertainment, to wellness and even medicine. While impressive advancements have been made in visual display for smartphones and visual technology for representing 3D space in VR, the ability to do so via audio (particularly in the back and the vertical dimensions) remains very limited. Following an initial implementation developed under the NovelExper",{"id":882,"funder":7,"programme":8,"title":883,"piName":10,"institution":884,"country":20,"year":13,"amount":14,"abstract":885},"cordis-european-research-council-award-101123468","Metabolic anti-inflammatory nanomedicines","FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA","Our proposal is to create new nanomedicines for identifying anti-inflammatory therapies. Through the optimisation of synthetic procedures, we aim to control the primary sequence of the polymer, the size of the nanomedicine, and degradation profiles. High-content in vitro screening will be utilised to determine which formulations can most selectively target macrophages and have the strongest anti-inflammatory effect. To test the effectiveness of these formulations, we will collaborate with specia",{"id":887,"funder":7,"programme":8,"title":888,"piName":10,"institution":142,"country":143,"year":13,"amount":14,"abstract":889},"cordis-european-research-council-award-101123257","NatureCOLOURS: Natural colours delivered by yeast fermentation","Colour is an essential characteristic of food, associated with quality, freshness, and taste perception. Natural and synthetic food dyesare added to processed foods to enhance or correct variations and give an expected colour to colourless foods, such as soft drinks orcandies. Many synthetic colours cause hyperactivity in children, trigger hypersensitivity reactions, and some are carcinogenic in animalstudies. Natural colours do not have such adverse effects and are even health-promoting. While ",{"id":891,"funder":7,"programme":8,"title":892,"piName":10,"institution":893,"country":37,"year":13,"amount":14,"abstract":894},"cordis-european-research-council-award-101123099","Development of smart skin for high resolution multi-sensing","UNIVERSITA DEGLI STUDI DI BARI ALDO MORO","Artificial skins are made of sensors embedded in flexible matrices that record several stimuli from the environment and transform them into measurable signals. At the moment, different sensors have to be implemented in the electronic skin matrix for each stimulus. As a result, the existing technologies are complex, expensive, sometimes based on toxic materials or are not able to demonstrate multi-stimuli responsiveness and high resolution.  With Smart Skin we will create a prototype for artifici",{"id":896,"funder":7,"programme":8,"title":897,"piName":10,"institution":703,"country":97,"year":13,"amount":14,"abstract":898},"cordis-european-research-council-award-101122563","Metal nanoapertures by nanoimprint to enhance single molecule fluorescence detection","After two decades of parallel developments in single molecule fluorescence techniques and nanophotonics, these two fields remain largely disconnected today. The aim of the PrintNano4Fluo project is to bridge this gap and bring nanophotonics tools to the end users single molecule microscopists. Our objective is to develop a new cost-effective and scalable nanofabrication approach of nanophotonic devices to enhance single molecule fluorescence detection. The PrintNano4Fluo solution offers a unique",{"id":900,"funder":7,"programme":8,"title":901,"piName":10,"institution":211,"country":37,"year":13,"amount":14,"abstract":902},"cordis-european-research-council-award-101123385","ElectrIfied ammoNia CrAcking iN sTructured reactors","In view of the ongoing energy transition, solutions for the transportation and storage of hydrogen are urgently needed. Ammonia is recognized in principle as the best hydrogen carrier, but a bottleneck is represented by the lack of efficient industrial technologies for ammonia decomposition (cracking), a necessary step for hydrogen recovery.Capitalizing on the previous ERC projects of the PI (INTENT, AdG 2015; INSTANT, PoC 2020), INCANT proposes to develop an innovative reactor technology to val",{"id":904,"funder":7,"programme":8,"title":905,"piName":10,"institution":148,"country":149,"year":13,"amount":14,"abstract":906},"cordis-european-research-council-award-101123107","Innovative digital twin concept of complex microstructure evolution in multi-component materials","Tailoring the microstructural features in metal additive manufacturing (AM) products is still a great challenge, limiting the design flexibility and full exploitation of the technique. The aim of muTWIN is to implement and validate an innovative digital twin concept of microstructure evolution in technical alloys. The new concept allows for fast and accurate computation of local microstructures in AM parts as a function of local composition and temperature history. When integrated in thermal and",{"id":908,"funder":7,"programme":8,"title":909,"piName":10,"institution":311,"country":312,"year":13,"amount":14,"abstract":910},"cordis-european-research-council-award-101137726","NeuroProtect – A novel therapy to prevent Chemotherapy-Induced Peripheral Neuropathy","Chemotherapy induced peripheral neuropathy (CIPN) is a debilitating neural condition that affects millions of European cancer patients every year. It is considered by patients and oncologists to be the most significant long-term impact of cancer treatment and often results in devastating consequences for patients, including an inability to work or perform the basic tasks of daily living. With chemotherapy usage set to increase by 53% by 2040, CIPN remains a clear and urgent unmet patient need. C",{"id":912,"funder":7,"programme":8,"title":913,"piName":10,"institution":72,"country":31,"year":13,"amount":14,"abstract":914},"cordis-european-research-council-award-101138056","Reducing Carbon Footprint for Generative AI","Executive summary:Generative AI systems, such as chatGPT, recently passed the Turing test, forever transforming human-machine interaction. These systems provide giant productivity leaps across many sectors. However, their energy requirements increase nine-fold annually and their abundance grows at exponential rate. The resulting carbon footprint becomes significant. IT giants such as Google, Nvidia, Microsoft, and Amazon, as well as many mid-sized companies, have committed to reduce their carbon",{"id":916,"funder":7,"programme":8,"title":917,"piName":10,"institution":918,"country":175,"year":13,"amount":14,"abstract":919},"cordis-european-research-council-award-101137959","Functionalized graphenes for ink technologies","UNIVERZITA PALACKEHO V OLOMOUCI","GRADERINK addresses the pressing need for development of novel inks that can be utilized for inkjet printing of stable, selective, sensitive, and eco-friendly electrodes. Project aims to deliver the upscaling of an industrially relevant novel manufacturing process for graphene-derivative based ink, enabling a significant progress in the printing technologies for versatile electrochemical biosensing platform. Such platform can be utilized for a wide range of medicinally, environmentally and food\u002F",{"id":921,"funder":7,"programme":8,"title":922,"piName":10,"institution":923,"country":43,"year":13,"amount":14,"abstract":924},"cordis-european-research-council-award-101138879","Tailored Bacterial Magnetic Nanoparticles For Biomedical Imaging","UNIVERSITAT BAYREUTH","Of tremendous biomedical and clinical interest are magnetic iron oxide nanoparticles (MNP) that can be tailored to fulfil specific functions, for instance as actuated drug carriers, tracers for magnetic imaging modalities, or heat generators in magnetic hyperthermia for cancer therapy. However, their use in real-world applications has been hampered by lack of precise size control and magnetic tunability as well as by poor biocompatibility associated with their conventional synthesis. I propose a",{"id":926,"funder":7,"programme":8,"title":927,"piName":10,"institution":771,"country":97,"year":13,"amount":14,"abstract":928},"cordis-european-research-council-award-101137960","Preclinical in vivo validation of a glioblastoma neuro snooper electrical device","Median survival for people that are diagnosed with glioblastoma (GBM) is only 15 months. Chemoradiotherapy and targeted therapies still fail to combat peritumoral relapse after tumour removal. Preventing peritumoral brain invasion is the main target to cure GBM. Our project aims to validate a proof-of concept for a new medical device (MD) ‘GBM Neuro Snooper’ in GBM animal models, a required step before initiating a clinical trial (Technology Readiness Level from 2\u002F3 to 4). This MD will allow to ",{"id":930,"funder":7,"programme":8,"title":931,"piName":10,"institution":932,"country":124,"year":13,"amount":14,"abstract":933},"cordis-european-research-council-award-101122976","The Modern Argonauts: A Multicultural Educational Programme Preparing Young People for Contemporary Challenges through an Innovative Use of Classical Mythology","UNIWERSYTET WARSZAWSKI","The Preamble to the EU Charter of Fundamental Rights speaks of the peoples of Europe who are conscious of its heritage and wish to share a peaceful future based on such common values as dignity, equality and solidarity. One of the crucial sources of these values is Classical Antiquity, which laid the foundations for many ideas shaping our contemporary world. In particular, the ancient myths and their reception build a sense of community and a code of reciprocal understanding  so important in tim",{"id":935,"funder":7,"programme":8,"title":936,"piName":10,"institution":492,"country":149,"year":13,"amount":14,"abstract":937},"cordis-european-research-council-award-101123162","A highly efficient CRISPR\u002FCas9 gene editing method for difficult to transform arthropods","During the ERC consolidator grant POLYADAPT, an efficient gene editing system was discovered which allows to genetically transform the spider mite, Tetranychus urticae, a main crop pest. This species belongs to the chelicerates, the second largest group of arthropods including mites, ticks and spiders, that are notoriously difficult to transform. Our invention not only accomplished for the first time gene knock-out in mites, but also allows precise gene editing via knock-in with high efficiency.",{"id":939,"funder":7,"programme":8,"title":940,"piName":10,"institution":941,"country":12,"year":13,"amount":14,"abstract":942},"cordis-european-research-council-award-101138283","SpikeZip: a retinomorphic encoding method for low-latency and loss-less data compression and telemetry of large-scale in-vivo neural recordings","STICHTING IMEC NEDERLAND","In-vivo neural recording and transmission of a vast number of neurons is essential in comprehending the brain and nervous system. However, the core challenge in the field of high-channel-count in-vivo neural recording is the limitation in transferring data posed by the bandwidth and energy consumption, which currently lacks a viable telemetry solution to effectively address this challenge. This PoC project introduces a novel retinomorphic encoding method, SpikeZip, which offers several advantage",{"id":944,"funder":7,"programme":8,"title":945,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":946},"cordis-european-research-council-award-101123220","Moving from whole genome cfDNA methylation to a PCR-based liquid biopsy assay for detecting high-risk atherosclerotic plaques","General practitioners and cardiologists are faced every day with challenging decisions on whom to refer for diagnostics of coronary artery disease (CAD) as sign and symptoms of cardiac ischemia require immediate action. Diagnosis of CAD is key as ischemic heart disease accounts for 45% of deaths in females and 39% in males in the European Union. Yet, diagnosis of CAD in women is regularly delayed and often unrecognized. As the main pathology underlying CAD, it is essential to understand atherosc",{"id":948,"funder":7,"programme":8,"title":949,"piName":10,"institution":798,"country":43,"year":13,"amount":14,"abstract":950},"cordis-european-research-council-award-101138939","Efficient, safe, and cost-efficient RNA delivery vehicles for hard-to-transfect pre-clinical and therapeutic cells.","Human induced pluripotent stem cells (hIPSCs) have revolutionized the study of cell type-specific processes and the generation of organoids, tissues, and therapeutic cells for biomedical purposes. 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