[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-proof-of-concept-2024":3,"awarded-stats-erc-proof-of-concept":957},{"awarded":4,"total":956},[5,16,22,28,34,40,46,52,57,62,67,72,77,81,86,90,96,101,106,112,117,122,128,133,137,142,147,152,158,162,167,172,177,182,187,193,199,203,209,215,220,225,230,234,240,245,249,254,259,264,269,273,278,283,287,291,296,301,306,311,315,320,325,329,334,339,344,349,354,359,363,368,372,377,382,387,391,396,400,405,409,414,418,422,428,433,438,442,447,451,456,461,465,470,474,479,484,488,493,497,501,505,510,514,519,523,528,534,538,542,547,552,557,561,566,570,574,579,583,588,593,598,603,608,613,618,623,627,631,635,640,645,649,654,659,664,669,674,678,683,688,694,699,703,707,712,717,721,725,729,734,738,743,747,751,756,760,765,770,775,781,786,791,796,801,805,810,814,818,822,826,830,834,839,844,849,853,858,862,866,872,876,880,885,889,893,897,902,906,910,914,918,922,926,930,934,939,943,947,951],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-101069368","European Research Council","ERC Proof of Concept","MINIMAL SAPONIN-BASED ADJUVANT VACCINE PLATFORM",null,"ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS","ES",2024,"€150,000","ADJU-PLATFORM seeks to leverage a breakthrough made in the ERC-2016-STG-716878 project to validate a synthetic technological platform for the efficient production of optimised saponin adjuvants and improved cost-effective vaccines. We have recently developed in the laboratory a potent, safe, stable and streamlined platform based on an optimised version of the vaccine adjuvant QS-21 that has led to patent applications and raised the interest of the pharmaceutical industry. In this PoC project, we",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":20,"year":13,"amount":14,"abstract":21},"cordis-european-research-council-award-101189389","Differential Diagnosis of Autoimmune Hepatitis by cfChIP-seq Liquid Biopsy","THE HEBREW UNIVERSITY OF JERUSALEM","IL","The identification of the causative agent and mechanism of liver disorders is essential for effective treatment. The diagnostic challenge is differentiating autoimmune hepatitis, drug induced liver damage, and other non-viral causes of liver disease. Current diagnostic guidelines require in many cases liver biopsy followed by monitoring response to treatment before conclusive diagnosis. Our objective is to replace liver biopsy in the parenchymal liver disease settings with a minimally invasive l",{"id":23,"funder":7,"programme":8,"title":24,"piName":10,"institution":25,"country":26,"year":13,"amount":14,"abstract":27},"cordis-european-research-council-award-101188114","Cultivating Color: Harnessing bacteria for Sustainable Pigments in circular economy","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","DE","Confidential",{"id":29,"funder":7,"programme":8,"title":30,"piName":10,"institution":31,"country":32,"year":13,"amount":14,"abstract":33},"cordis-european-research-council-award-101189371","ELVER-CHECK: Well-grounded Lightweight Assurance for Critical Systems Software","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","UK","Computer systems have become critical to modern society, but they are pervasively subject to security flaws and attacks, with large-scale exposures of confidential data, denial-of-service and ransom attacks, and the threat of nation-state attackers: they are trusted, but are far from trustworthy. This is especially important for the systems software enforces what protection, eg the hypervisors that use the underlying hardware to isolate components from each other.ERC AdG ELVER has developed math",{"id":35,"funder":7,"programme":8,"title":36,"piName":10,"institution":37,"country":38,"year":13,"amount":14,"abstract":39},"cordis-european-research-council-award-101187919","Advanced Molecular ENantiodiscrimination","INSTITUT POLYTECHNIQUE DE BORDEAUX","FR","Enantiodiscrimination is one of the major challenges in contemporary chemistry. Chiral molecules exist in two non-superimposable mirror image forms, which induce different effects in biological systems. Thus, they need to be produced in a stereoselective way, especially for pharmaceutical use. The motivation and societal relevance of this project is based on the fact that if the wrong enantiomers are present in pharmaceuticals, their effects can be toxic or even lethal, as has been exemplified b",{"id":41,"funder":7,"programme":8,"title":42,"piName":10,"institution":43,"country":44,"year":13,"amount":14,"abstract":45},"cordis-european-research-council-award-101189152","Nanoengineered photoactivated drug-free antimicrobial precision treatment for chronic skin wounds","KAROLINSKA INSTITUTET","SE","Antibiotic-resistant bacterial skin and soft tissue infections (SSTIs) are difficult to diagnose and treat, prolonging hospital stays and lowering quality of life. Chronic wounds harbour antibiotic-resistant microorganisms that form biofilms, leading to conditions like diabetic foot ulcers (DFUs). Approximately 50% of DFUs become infected, making them the most prevalent and costly diabetes complication, with a higher mortality and morbidity risk from lower limb amputation. There is an urgent nee",{"id":47,"funder":7,"programme":8,"title":48,"piName":10,"institution":49,"country":50,"year":13,"amount":14,"abstract":51},"cordis-european-research-council-award-101189355","Self-feeding implants to improve and accelerate tissue healing using nutritional nanoparticles","UNIVERSITEIT TWENTE","NL","Keeping large (>1cm3) living tissues alive is an unresolved key challenge that hinders many clinical and industrial applications, including tissue\u002Forgan transplants, engineered tissues, drug screening models, and lab grown meat. While natural tissues within our body are continuously provided with nutrients via the blood stream, engineered, explanted, or even implanted tissues have to rely on the slow diffusion of nutrients until perfused vascularization is achieved. This commonly leads to tissue",{"id":53,"funder":7,"programme":8,"title":54,"piName":10,"institution":55,"country":38,"year":13,"amount":14,"abstract":56},"cordis-european-research-council-award-101188025","An Application for leveraging large-scale historical textbases","UNIVERSITE D'AIX MARSEILLE","HistText is a groundbreaking application developed to address the complex challenges of large-scale data mining in textual corpora, with a particular focus on historical documents. Created in the context of the ERC-funded ENP-China project, which aims to study the evolution of Chinese elites from the 19th century to 1949, HistText is the result of a synergistic collaboration between historians and computer scientists exploring machine learning applications for extensive text archives. Designed t",{"id":58,"funder":7,"programme":8,"title":59,"piName":10,"institution":60,"country":26,"year":13,"amount":14,"abstract":61},"cordis-european-research-council-award-101188249","Preventing Alport syndrome with a natural amino acid","UNIVERSITATSKLINIKUM HEIDELBERG","Chronic kidney disease (CKD) is a major burden on society, causing significant morbidity and mortality. A typical symptom of CKD is the loss of protein into the urine, also termed proteinuria, which is usually associated with a poor prognosis. In most cases, a defective glomerulus leads to proteinuria, resulting in damage of the neighboring proximal tubular cells due to protein and lipid overload. In RENOTREAT, we aim to treat Alport syndrome with a natural amino acid, that is known to inhibit t",{"id":63,"funder":7,"programme":8,"title":64,"piName":10,"institution":65,"country":20,"year":13,"amount":14,"abstract":66},"cordis-european-research-council-award-101188779","Fingerprinting Single Protein Molecules for Biomarker Assisted Precision Medicine","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","Protein molecule sensing techniques are currently hampered by detection limits and require large samples to achieve acceptable levels of sensitivity, bias, throughput, cost, and time to result. Leveraging findings from our NanoProt-ID (ADG ERC), in SM-ProTrack we will develop a novel single-molecule sensing method with unprecedented levels of detail and accuracy. This technology is based on the separation of molecules using silicon nano-channels on a chip, tracking of single molecules, and high-",{"id":68,"funder":7,"programme":8,"title":69,"piName":10,"institution":70,"country":12,"year":13,"amount":14,"abstract":71},"cordis-european-research-council-award-101189188","Computer aided de novo design of nanobodies","FUNDACIO CENTRE DE REGULACIO GENOMICA","Antibodies have become major players in the pharmaceutical industry and were valued at 0.16 US billion in 2023.  Traditionally, antibodies are obtained after immunisation of different animals and then produced in relevant cells for use in research, diagnostics and therapy. In recent years, there is a growing public opinion in Europe to ban the use of animals for biomedical research, and therefore there is an increasing pressure to move from animal produced antibodies to design and produce them i",{"id":73,"funder":7,"programme":8,"title":74,"piName":10,"institution":75,"country":44,"year":13,"amount":14,"abstract":76},"cordis-european-research-council-award-101187914","Acoustic whole blood imaging flow cytometry for rare cell identification","LUNDS UNIVERSITET","This project addresses the need for new tools to detect and monitor the disease progression in patients with metastatic cancer. Breast and prostate cancer are the most common malignant cancers in women and men, respectively. Metastasis is the main threat in these cancers since it turns a curable local disease into a chronic lethal disease. With emerging new targeting therapies, there is an unmet clinical need for improved prognostication, treatment prediction and treatment monitoring, where circ",{"id":78,"funder":7,"programme":8,"title":79,"piName":10,"institution":75,"country":44,"year":13,"amount":14,"abstract":80},"cordis-european-research-council-award-101189370","Driving tumour antigen presentation by RNA-mediated transdifferentiation","Immunotherapy has transformed cancer treatment, but targeting effectively refractory solid tumors remains a challenge due to poor T cell activation. Downregulation of antigen presentation pathways and lack of professional antigen presenting cells in the tumor microenvironment contribute to immune evasion. My group has demonstrated direct reprogramming of fibroblasts or tumor cells into type 1 conventional dendritic cells (cDC1) cells by overexpression of the transcription factors PU.1, IRF8, and",{"id":82,"funder":7,"programme":8,"title":83,"piName":10,"institution":84,"country":26,"year":13,"amount":14,"abstract":85},"cordis-european-research-council-award-101113162","Validation of a novel device for real-time, long-term measurement of cellular forces","UNIVERSITAT ZU KOLN","The conventional thinking in cell biology, which often assumes that cells communicate mostly via bio-chemical signalling, has recently been challenged with several examples where mechanical rather than chemical cues play an important role in development, physiology and disease. Biological cells continually exert forces on their environment, which can vary substantially in magnitude, spatial distribution and temporal evolution. These forces are key to many processes including cell growth, tissue ",{"id":87,"funder":7,"programme":8,"title":88,"piName":10,"institution":19,"country":20,"year":13,"amount":14,"abstract":89},"cordis-european-research-council-award-101188783","Acute pancreatitis therapy by RORα activation and FGF21 expression","Pancreatitis in humPancreatitis in humans is a cause of significant morbidity and mortality. Acute pancreatitis events have increased worldwide over the last 20 years at an average annual percent change of 3% and the economic burden is growing (1). Treatments for pancreatitis are currently limited. The overall mortality rate in acute severe pancreatitis is 10-15%. Thus, a specific treatment for pancreatitis is of great need. Recent reports suggest that FGF21 can ameliorate acute pancreatitis in ",{"id":91,"funder":7,"programme":8,"title":92,"piName":10,"institution":93,"country":94,"year":13,"amount":14,"abstract":95},"cordis-european-research-council-award-101112697","Enabling Wireless Information and Power Transfer through Low-Complexity Waveform Techniques","UNIVERSITY OF CYPRUS","CY","Wireless information and power transfer (WIPT) is a new communication paradigm, which is based on the dual-use of radio-frequency (RF) signals as a means to convey information and energize low power devices. WIPT is an attractive and promising technology for the upcoming 6G communication systems, which are characterized by the massive connectivity of heterogeneous ultra-low-power devices under the umbrella of the Internet of Things (IoT). Due to the nonlinearity of the rectification process, the",{"id":97,"funder":7,"programme":8,"title":98,"piName":10,"institution":99,"country":50,"year":13,"amount":14,"abstract":100},"cordis-european-research-council-award-101189439","Deep multiplexed epigenetic profiling of plasma cell-free nucleosomes for early cancer diagnostics","KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW","Over recent years, cancer diagnostics based on cell-free DNA (cfDNA) in liquid biopsies demonstrated great promise in guiding treatment and screening for recurrent diseases. Current diagnostic strategies are mainly based on the analyses of DNA mutations, fragment length or DNA methylation status. However, these strategies do not provide a universal approach for cancer identification, are costly and labour intensive, and generally fall short in detecting cancer at early tumorigenic stages or mini",{"id":102,"funder":7,"programme":8,"title":103,"piName":10,"institution":104,"country":50,"year":13,"amount":14,"abstract":105},"cordis-european-research-council-award-101189234","Benchmarking AI to predict mutagenicity by combing chemical structure and genome-wide mutation data","PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV","Assessing mutagenicity, the capacity of a substance to cause permanent and potentially harmful changes to an organism's DNA, is a pivotal concern in drug development. This assessment is crucial because it helps to predict the carcinogenic potential of new pharmaceuticals, ensuring that they are safe for human use. The importance of evaluating mutagenicity in drug development cannot be overstated. Drugs are designed to interact with biological systems to treat or prevent diseases, but they must d",{"id":107,"funder":7,"programme":8,"title":108,"piName":10,"institution":109,"country":110,"year":13,"amount":14,"abstract":111},"cordis-european-research-council-award-101111993","Targeting the Polycomb Machinery in BAP1-related Pathologies","ISTITUTO EUROPEO DI ONCOLOGIA SRL","IT","BAP1-related mutations are common genetic lesions of several cancers and neurodevelopmental disorders (NDDs). BAP1 is a deubiquitinase that removes the repressive mono-ubiquitination at histone H2AK119 (H2Aub1) deposited by the Polycomb Repressive Complex 1 (PRC1) by associating with several regulatory subunits to form the Polycomb Repressive Deubiquitinase (PR-DUB) complex.BAP1 inactivating mutations represent a hallmark in Malignant Mesothelioma (MM) for which genetic models proved its oncogen",{"id":113,"funder":7,"programme":8,"title":114,"piName":10,"institution":115,"country":50,"year":13,"amount":14,"abstract":116},"cordis-european-research-council-award-101188929","Developing a human-based stem cell model for reproductive toxicity","ACADEMISCH ZIEKENHUIS LEIDEN","Environmental factors and chemicals are thought to be one cause of declining male fertility.  Reproductive toxicity is becoming a major public health problem. Currently, new pharmacological or chemical compounds are tested in animals for their effects on reproduction before entering the market. This risk assessment is essential but time-consuming, expensive and is not always predictive in humans since animals have different reproductive characteristics and physiology. A validated and qualified h",{"id":118,"funder":7,"programme":8,"title":119,"piName":10,"institution":120,"country":110,"year":13,"amount":14,"abstract":121},"cordis-european-research-council-award-101188238","Harnessing the Market Potential of Single-Atom Catalysts through Next-Generation Large-Scale Synthesis","POLITECNICO DI MILANO","The CATSYNEX project, born from the ERC-StG SAC_2.0 project, addresses the pressing need for scalable production of single-atom catalysts to revolutionize industrial catalysis.While homogeneous catalysts dominate pharmaceutical synthesis due to their precision, they suffer from recovery, instability, and cost issues. Heterogeneous catalysts offer easier separation but struggle with lower degree of selectivity and activity when used in pharmaceutical reactions.Single-atom catalysts bridge this ga",{"id":123,"funder":7,"programme":8,"title":124,"piName":10,"institution":125,"country":126,"year":13,"amount":14,"abstract":127},"cordis-european-research-council-award-101188997","Metal-Organic-Framework Kinetic Array for Diabetes Detection","KATHOLIEKE UNIVERSITEIT LEUVEN","BE","Diabetes mellitus is a global health concern affecting 537 million people and resulting in over 6.7 million deaths yearly. Diagnosis currently relies on blood analysis, which is expensive, time-consuming, and invasive. Breath analysis based on the detection of volatile organic compounds (VOCs) is a promising non-invasive alternative. However, selectively measuring specific VOCs in breath is challenging due to their low concentrations and the presence of interfering compounds. Since current minia",{"id":129,"funder":7,"programme":8,"title":130,"piName":10,"institution":131,"country":110,"year":13,"amount":14,"abstract":132},"cordis-european-research-council-award-101189340","Enzyme-Linked DNA Displacement (ELIDIS) Assay as an innovative immunoassay platform","ISTITUTO NAZIONALE DI BIOSTRUTTURE E BIOSISTEMI","Since its introduction more than 50 years ago, ELISA (Enzyme-Linked Immunosorbent Assay) remains one of the most widely used technologies for research, drug discovery and diagnosis. The reasons for this extraordinary longevity are manifold: ELISA combines the high specificity of antibody-antigen interactions with the high sensitivity of enzyme amplification. However, ELISA also has disadvantages: multiple washing steps and reagents are required and a specialized instrument is needed, which is no",{"id":134,"funder":7,"programme":8,"title":135,"piName":10,"institution":31,"country":32,"year":13,"amount":14,"abstract":136},"cordis-european-research-council-award-101188879","Beyond the bandgap: HyperSpectral image sensors from ultraviolet to infrared","In this ERC Proof-of-Concept project we will create a high-performance and scalable platform for spectrally resolved imaging in a highly compact on-chip device structure. This new concept for a hyperspectral imaging system will exploit three key outcomes of my ERC Starting Grant: (i) photoconductivity phenomena in semiconductor nanowires, (ii) high-throughput characterisation techniques for individual nanostructures and (iii) automated adaptive manufacturing processes for building functional nan",{"id":138,"funder":7,"programme":8,"title":139,"piName":10,"institution":140,"country":26,"year":13,"amount":14,"abstract":141},"cordis-european-research-council-award-101069307","Linker molecules convert commercial fluorophores into tailored functional probes during biolabeling","TECHNISCHE UNIVERSITAT DORTMUND","Fluorescence techniques are indispensable tools at the heart of basic research, medical diagnostics, cancer research, personalized medicine and drug screening. Their merits are not limited by physical instrumentation, but by the performance and properties of the employed fluorescent probes. All commercially available fluorophores – with a market potential of 2 billion € per year and an annual growth rate of ~8% – suffer from three fundamental problems: (i) Phototoxicity and poor signal quality, ",{"id":143,"funder":7,"programme":8,"title":144,"piName":10,"institution":145,"country":32,"year":13,"amount":14,"abstract":146},"cordis-european-research-council-award-101189504","Sensorised Surgical Glove for Safer Operative Births","UNIVERSITY COLLEGE LONDON","We seek to develop and validate a sensorised surgical gloves. The sensors are based on a multifunctional nanocomposite which is nontoxic and can serve as ultrathin tactile sensors, integrated directly on the fingertips of surgical gloves. These sensorised gloves enable mechanical energy harvesting, force sensing and assessment of several other mechanical parameters from fingertips. Having completed laboratory validation, ex vivo testing and low risk investigations to establish the protocols and ",{"id":148,"funder":7,"programme":8,"title":149,"piName":10,"institution":150,"country":110,"year":13,"amount":14,"abstract":151},"cordis-european-research-council-award-101189244","Novel production routes for the fabrication of tailor-made, crystalline, self-structuring oleogels for functional food and pharmaceutical applications","POLITECNICO DI TORINO","One out of five deaths in the EU in 2017 were linked to unhealthy diets and it is estimated that 53% of the EU population is overweight or obese, creating an unsustainable burden on national sanitary systems. Overconsumption of fats, particularly saturated ones, is one of the main causes of obesity; hence promoting diets that are lower in fats is essential. One strategy could be the reformulation of fatty foods with a lower amount of both saturated and total fats. However, this is challenging as",{"id":153,"funder":7,"programme":8,"title":154,"piName":10,"institution":155,"country":156,"year":13,"amount":14,"abstract":157},"cordis-european-research-council-award-101189403","CO2 Mineralisation:  Conversion of Waste to New Building Materials","DANMARKS TEKNISKE UNIVERSITET","DK","The goal of MIN CO2 is to test the innovation and commercialisation potential of an idea for: i) increasing sustainability, ii) decreasing atmospheric CO2 and iii) producing a valuable, low CO2 footprint building material from noncombustible solid waste. Results from our ERC research led to the idea: Can we react waste materials with CO2 and water to produce fine grained material of value for new concrete? Current solutions for CCS are expensive and require extensive infrastructure but if this i",{"id":159,"funder":7,"programme":8,"title":160,"piName":10,"institution":25,"country":26,"year":13,"amount":14,"abstract":161},"cordis-european-research-council-award-101189408","Natural scavenger repellents from Xenorhabdus and Photorhabdus","The ecology of Xenorhabdus and Photorhabdus (XP) bacteria requires the production of bioactive natural products against invertebrates, vertebrates, bacteria, and fungi. XPdeter will especially selected metabolites for their application in agriculture. XPdeter aims to (i) validate promising compound classes in the lab and in the field in different bioassays, (ii) create and test a library of synthetically and more accessible derivatives, and (iii) produce the optimized metabolites biotechnologica",{"id":163,"funder":7,"programme":8,"title":164,"piName":10,"institution":165,"country":50,"year":13,"amount":14,"abstract":166},"cordis-european-research-council-award-101189462","Super-resolution microscopy for semiconductor metrology","STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN","Super-resolution microscopy has revolutionized imaging by breaking what was believed to be unbreakable: the diffraction limit  which determines what a microscope can resolve. However, many disciplines in science and engineering cannot benefit from super-resolution microscopy, because practically all current super-resolution microscopes require fluorescence, often introduced by labelling  that is chemically modifying  the samples of interest. The semiconductor industry is the driver of digitizati",{"id":168,"funder":7,"programme":8,"title":169,"piName":10,"institution":170,"country":50,"year":13,"amount":14,"abstract":171},"cordis-european-research-council-award-101189352","Cloud-native ultrasound imaging","TECHNISCHE UNIVERSITEIT EINDHOVEN","Ultrasound (US) can revolutionize and democratize medical imaging if it offers: (1) access for everyone, and (2) excellent image quality, always. MRI offers (2) but is expensive and will thus not likely be able to provide (1). Low-cost US hardware will enable (1) in the future but is not expected to yield the needed breakthrough for (2). Any solution that addresses both will have a huge impact.The biggest adversaries for US image quality stem from patient- and user-specific factors. I therefore ",{"id":173,"funder":7,"programme":8,"title":174,"piName":10,"institution":175,"country":50,"year":13,"amount":14,"abstract":176},"cordis-european-research-council-award-101183378","Glyco-protein arrays for functional virus surveillance","UNIVERSITEIT UTRECHT","This ERC PoC project aims to establish the technical and commercial feasibility of our recently developed glycan-arrays in which we determined the minimal receptor for duck, chicken, and human influenza A viruses, respectively. We also determined structures vital for viruses as intermediate receptors on the avian-mammalian interface. With our experience in printing arrays, we also want to add proteinaceous receptors for coronaviruses. This mixed glyco-protein array will then be employed for func",{"id":178,"funder":7,"programme":8,"title":179,"piName":10,"institution":180,"country":110,"year":13,"amount":14,"abstract":181},"cordis-european-research-council-award-101189208","Tablet Games for Early Detection and Intervention of Developmental Dyscalculia","UNIVERSITA DEGLI STUDI DI TRENTO","The ultimate goal of the project is to provide a screening and rehabilitation method for the early detection and treatment of developmental dyscalculia (DD), in the form of an entertaining, tablet-based gaming environment. DD is a common learning disability and severely impacts personal and professional development throughout the lifespan. Early diagnosis and interventions increase the possibilities for people with DD to live an independent and productive life. Children with DD have difficulties",{"id":183,"funder":7,"programme":8,"title":184,"piName":10,"institution":185,"country":12,"year":13,"amount":14,"abstract":186},"cordis-european-research-council-award-101189474","Emulation of Wireless Communication among Chiplets inside a Computing System","UNIVERSITAT POLITECNICA DE CATALUNYA","Domain specialisation (e.g., AI) coupled with skyrocketing manufacturing costs of chips led to a paradigm shift towards chiplet-based computing. However, the current Network-on-Package (NoP) is not suited for the increasing chiplet (CPUs, AI accelerators, etc) count and diverse communication needs. As a result, communication has become the main bottleneck to computing advances.Wireless transmission can enable one-hop communication with low latency parallelism. The wireless links can be reconfigu",{"id":188,"funder":7,"programme":8,"title":189,"piName":10,"institution":190,"country":191,"year":13,"amount":14,"abstract":192},"cordis-european-research-council-award-101188296","Accelerating biofilm Matrix dispersion with Deep Eutectic Solvents","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","IE","A growing demand for clean water is driving the increased adoption of water-recycling and water-desalination, particularly in water-stressed regions. These processes are highly dependent on the use of membrane filtration technology. Efficient operation of these membranes is hampered by biofouling which is typically managed by chemical treatment. Amongst end-users in the water treatment sector, there is a market-pull towards more green\u002Fsustainable chemicals and this, combined with the limited eff",{"id":194,"funder":7,"programme":8,"title":195,"piName":10,"institution":196,"country":197,"year":13,"amount":14,"abstract":198},"cordis-european-research-council-award-101189009","Monolithic Silicon Quantum Communication Circuitry","AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH","AT","The advent of quantum computing and its unprecedented computational power has called the sustainability of today’s widely established encryption methods into question. Even though quantum physics addresses this emerging threat by offering quantum key distribution (QKD) at the same time, the complexity inherent to QKD systems constitutes a roadblock for their practical introduction, especially when addressing telecommunication segments that are subject to commodity-like applications.MOSQITO is an",{"id":200,"funder":7,"programme":8,"title":201,"piName":10,"institution":125,"country":126,"year":13,"amount":14,"abstract":202},"cordis-european-research-council-award-101188255","Sound insulation prediction and optimization","With urbanization accelerating on a global scale, airborne and impact sound insulation have become key performance quantities of building elements. Unfortunately, acoustic requirements do not naturally align with structural and thermal requirements. Achieving good sound insulation is difficult, especially for innovative, more sustainable building systems which are typically lightweight. There is an urgent need in the construction sector for adequate sound insulation design prediction software. I",{"id":204,"funder":7,"programme":8,"title":205,"piName":10,"institution":206,"country":207,"year":13,"amount":14,"abstract":208},"cordis-european-research-council-award-101113355","Light-driven surface shaping for holographic optical elements","TAMPEREEN KORKEAKOULUSAATIO SR","FI","Diffractive optical elements are the key technology for Augmented and Virtual Reality (AR & VR) displays. They are typically fabricated using nanoimprint lithography and reactive ion etching, which do not allow for reconfiguration of the structures. We present a novel solution for fabrication of diffractive optical elements using feedback-controlled, light-induced sub-micrometre scale surface shaping of azobenzene-containing films. The method allows for facile creation of complex surface relief ",{"id":210,"funder":7,"programme":8,"title":211,"piName":10,"institution":212,"country":213,"year":13,"amount":14,"abstract":214},"cordis-european-research-council-award-101081989","R4R: Reproducible Data Analyses for All","CESKE VYSOKE UCENI TECHNICKE V PRAZE","CZ","Unevaluated science is not worth funding. Gone are the days where a scientific breakthrough could be based on scribbles made on a few loose sheets of paper reviewed by a single attentive reader. Most disciplines rely on experimental data that is collected, analyzed, and presented using powerful computational tools. The scientific adventure hinges on our ability to openly and widely share and reproduce such results.The goal of this PoC is to market a tool, R4R, for non-programmer scientists to ma",{"id":216,"funder":7,"programme":8,"title":217,"piName":10,"institution":218,"country":26,"year":13,"amount":14,"abstract":219},"cordis-european-research-council-award-101113422","Sustainable Plasmonic Membranes for Water Remediation","UNIVERSITAET POTSDAM","Plasmon chemistry is an emerging field in which light energy is converted into chemical energy or heat in metal nanoparticles (NPs). Previously, we have investigated the degradation of small organic molecules such as brominated nucleobases and halogenated thiophenols through excitation of NPs by visible or even near-infrared light. These results inspired us to apply plasmonic nanomaterials to decompose organic micropollutants such as pharmaceuticals in waste water. Many pharmaceuticals are categ",{"id":221,"funder":7,"programme":8,"title":222,"piName":10,"institution":223,"country":20,"year":13,"amount":14,"abstract":224},"cordis-european-research-council-award-101185881","Innovative mucus secretion stimulation for inflammation control in Inflammatory Bowel Disease","BAR ILAN UNIVERSITY","Inflammatory bowel diseases (IBDs), such as Crohns disease and ulcerative colitis, are chronic, debilitating conditions affecting millions worldwide. There is currently no cure for IBD, only treatments aimed at inducing long lasting remission. These treatment options act mainly by inhibiting the patients immune system, leaving patients immunocompromised, and come with a high annual direct cost. Even with advanced treatment, most IBD patients will require surgery during their lifetimes. Thus, mor",{"id":226,"funder":7,"programme":8,"title":227,"piName":10,"institution":228,"country":26,"year":13,"amount":14,"abstract":229},"cordis-european-research-council-award-101188113","Preclinical development of new nucleoside-based drug against leukemia","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","The current treatment landscape for leukemia, particularly concerning AML (acute myeloid leukemia) and MDS (myelodysplastic syndrome), is constrained by the instability of hypomethylating agents which are regularly used in elderly, medically non-fit patients (high-risk). This instability restricts their spectrum of application, leaving a significant gap in effective treatment options. Despite research into alternative therapeutic approaches the need for a mild treatment option with high success ",{"id":231,"funder":7,"programme":8,"title":232,"piName":10,"institution":120,"country":110,"year":13,"amount":14,"abstract":233},"cordis-european-research-council-award-101189508","Neuromorphic computing system for real-time signal monitoring and classification with ultra-low-power 2D devices","The detection and classification of electrophysiological signals (EPSs), such as electroencephalography (EEG) and electromyography (EMG) recordings, are the gold standard in neuroscience, enabling the identification of digital biomarkers capable of health monitoring, personalised medicine and advanced brain-computer interfaces (BCIs). The state-of-the-art technology in this field, however, still relies on bulky, inefficient microelectronic systems which relies on artificial intelligence (AI) in ",{"id":235,"funder":7,"programme":8,"title":236,"piName":10,"institution":237,"country":238,"year":13,"amount":14,"abstract":239},"cordis-european-research-council-award-101188523","UR4energy: Underwater Robots for efficient ocean energy harvesting","NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU","NO","The renewable energy input in the grid is not sufficient to cover the European energy demand, which largely still depends on fossil fuels. To reach the goal of climate neutrality by 2050, Europe needs to diversify and improve the adoption of renewable energy technologies. A yet-untapped source of energy can be found in the ocean. While wave and tidal energy have been explored, the reliable and predictable vortex wake energy has not been harvested yet as a renewable energy source. UR4energy will ",{"id":241,"funder":7,"programme":8,"title":242,"piName":10,"institution":243,"country":207,"year":13,"amount":14,"abstract":244},"cordis-european-research-council-award-101189466","MODular and EXpandable multi-locus Transcranial Magnetic Stimulation","AALTO KORKEAKOULUSAATIO SR","We aim to develop and validate a versatile and affordable transcranial magnetic stimulation (TMS) system that can perform adaptive and automated brain stimulation. TMS is performed routinely in thousands of hospitals worldwide for diagnostics (e.g., to measure corticospinal excitability), for presurgical planning (to locate eloquent brain areas that should not be harmed), and for treating severe depression and neuropathic pain. Unfortunately, only about 50% of patients benefit from the treatment",{"id":246,"funder":7,"programme":8,"title":247,"piName":10,"institution":49,"country":50,"year":13,"amount":14,"abstract":248},"cordis-european-research-council-award-101187945","Realizing the benefits of safety-security co-analysis through effective tool support","Effective tool support for the joint analysis of safety and security risks is long overdue. Risk management is an important activity to ensure the reliable functioning of technology, such as power plants and self-driving cars. Risks include both safety  (= accidental failures) and security aspects (= malicious attacks). Historically, safety and security risks have been analyzed in isolation, despite often conflicting with each other. Effective decision-making requires considering safety and secu",{"id":250,"funder":7,"programme":8,"title":251,"piName":10,"institution":252,"country":12,"year":13,"amount":14,"abstract":253},"cordis-european-research-council-award-101189423","Therapeutic Effect of Nanobots in the Treatment of Joint Diseases","FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA","Arthritis, a widespread inflammatory condition, affecting millions globally, necessitates urgent advancements in therapeutic approaches. Predominantly characterized by osteoarthritis (OA), this debilitating condition causes joint pain and stiffness, notably impacting the knee, hand, and hip joints. OA, a chronic degenerative disease, intensifies with age, imposing a significant economic burden on healthcare systems. The insufficiency of current treatments highlights the need for innovative thera",{"id":255,"funder":7,"programme":8,"title":256,"piName":10,"institution":257,"country":32,"year":13,"amount":14,"abstract":258},"cordis-european-research-council-award-101189379","Wafer Scale Ultra-Clean Van der Waals Heterostructures","THE UNIVERSITY OF MANCHESTER","Two dimensional materials (2DM) and their van der Waals (vdW) heterostructures have opened new opportunities to developatomically thin electronic and optoelectronic devices with a wide range of functionalities. While thousands of research papersdemonstrate proof-of-concept studies with improved and novel performance using small-scale exfoliated crystals, a number ofchallenges still remains when these are attempted to be scaled up on wafer-scale with CVD grown 2DM. One of the key challenges isthe",{"id":260,"funder":7,"programme":8,"title":261,"piName":10,"institution":262,"country":197,"year":13,"amount":14,"abstract":263},"cordis-european-research-council-award-101189004","NR2F6 Blockade as Adoptive Immune Cell Therapy for Metastatic Melanoma","MEDIZINISCHE UNIVERSITAT INNSBRUCK","Melanoma cases and deaths are expected to increase in the coming years, representing a significant burden for the European economy and healthcare system. Metastatic melanoma (MM) is the most serious form of skin cancer and is characterised by uncontrolled metastatic spread of melanocytes to distant sites. Although standard treatments exist, significant clinical challenges remain, resulting in limited response and high MM recurrence rates. As a result of these limited treatment options, the quali",{"id":265,"funder":7,"programme":8,"title":266,"piName":10,"institution":267,"country":197,"year":13,"amount":14,"abstract":268},"cordis-european-research-council-award-101156734","Web3 Platform for Formal Mathematics","UNIVERSITAET INNSBRUCK","Mathematics is today on the verge of a revolution. Formal, computer-verified proofs become ubiquitous and largely adopted as the new means of communication and collaboration. This led to landmark proofs, such as Hales's verification of the Kepler conjecture and Scholze's condensed mathematics recently validated by computers, generating considerable momentum in the mathematical community. Simultaneously, there is growing industrial demand for formal proofs of software and hardware. Similarly, Web",{"id":270,"funder":7,"programme":8,"title":271,"piName":10,"institution":49,"country":50,"year":13,"amount":14,"abstract":272},"cordis-european-research-council-award-101158208","Advanced Magnetic Probes for Minimally Invasive Endovascular Surgery","Endovascular interventions in minimally invasive surgery (MIS) are vital for treating cardiovascular diseases through small incisions. However, current manual and tendon-driven instruments lack precision. Magnetic actuation offers a groundbreaking solution, providing exceptional dexterity. The APOLLO project aims to develop a flexible probe capable of generating internal magnetic fields, revolutionizing MIS with advanced diagnosis and treatment options. Integrated sensors and biocompatible mater",{"id":274,"funder":7,"programme":8,"title":275,"piName":10,"institution":276,"country":26,"year":13,"amount":14,"abstract":277},"cordis-european-research-council-award-101157312","Ultrafast Cathodoluminescence Spectroscopy  with  Coherent Electron-Driven Photon Sources","CHRISTIAN-ALBRECHTS-UNIVERSITAET  ZU KIEL","Exploring the optical responses of materials at the nanoscale is central to various fields of study, including quantum-sensitive measurement metrologies, photovoltaics, and optoelectronic devices. Electron probes have established themselves as important tools for visualizing nano-optical excitations with unprecedented spatial resolution. However, controlling optical excitations and exploring their decoherence dynamics require visualizing the dynamics of the nano-world at sub-femtosecond temporal",{"id":279,"funder":7,"programme":8,"title":280,"piName":10,"institution":281,"country":38,"year":13,"amount":14,"abstract":282},"cordis-european-research-council-award-101158105","High-Throughput Production of Extracellular Vesicles from Organoids under Rotating Motion","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","Extracellular vesicles (EVs) have emerged as pivotal regulators of both physiological homeostasis and pathological conditions, including cancer and regenerative diseases, and have recently been pinpointed as central effectors in the therapeutic capabilities of their parent cells. Nevertheless, the therapeutic market of EVs still has significant potential for further development. Specifically, EV production methods that deliver robust, scalable and high-yield productions, if possible with the min",{"id":284,"funder":7,"programme":8,"title":285,"piName":10,"institution":150,"country":110,"year":13,"amount":14,"abstract":286},"cordis-european-research-council-award-101138070","Photoelectrodes that STORE LIGHT energy","The European Green Deal requires novel solutions for renewable energy. Solar energy is not constant and hence an unstable power source owing to its intermittent nature. Therefore, storage of solar energy is an important issue. Our new technology combines solar energy conversion and storage into one, thus delivering the opportunity to exploit the benefits of solar energy conversion also beyond the availability of sunlight. Our compact two-in-one technology avoids the need to connect two separate ",{"id":288,"funder":7,"programme":8,"title":289,"piName":10,"institution":281,"country":38,"year":13,"amount":14,"abstract":290},"cordis-european-research-council-award-101138653","SALAMI : Sapphire and diAmond LAb-on-a-chip MIcrofluidics: microreactors for extreme conditions experimentation","Extreme conditions, i.e. high pressures, high temperature (HP\u002FHT) or harsh chemical environments are extremely difficult to study and to observe undisturbed in the field and to replicate in the laboratory. This critically slows down the rate of discoveries both for several industrial processes or in environmental sciences. New types of transparent reactors are needed to implement fast-screening to speed up experimentations in harsh conditions. While microfluidics could address these limitations,",{"id":292,"funder":7,"programme":8,"title":293,"piName":10,"institution":294,"country":50,"year":13,"amount":14,"abstract":295},"cordis-european-research-council-award-101158034","Explore Your Brain 2.0: a maximally effective, usable and scalable growth mindset intervention to break through adolescents’ declining rates of motivation and school achievements","STICHTING VU","Adolescence is a period of sharp declines in school motivation and achievement, with negative consequences not only for the academic success and mental wellbeing of youth, but also for teachers and parents. An interesting target for intervention is adolescents implicit belief that their abilities are malleable (growth mindset), which has been shown to protect against declines in motivation and achievement, and to boost resilience in school and beyond. This PoC builds on the innovative growth min",{"id":297,"funder":7,"programme":8,"title":298,"piName":10,"institution":299,"country":191,"year":13,"amount":14,"abstract":300},"cordis-european-research-council-award-101155899","Rejuvenation of the Intervertebral Disc Using Self-Healing Biomimetic Extracellular Matrix Biomaterial Tissue Adhesives","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","Lower back pain is a global epidemiological and socioeconomic problem. This project envisions a future whereby patients with degenerated intervertebral discs are injected with a self-healing biomimetic adhesive biomaterial which can restore both the biochemical and biomechanical properties to native tissue levels. Current surgical procedures do not replace herniated tissue from the central nucleus pulposus or repair the annulus fibrosus (outer ring of tissue), which can lead to accelerated degen",{"id":302,"funder":7,"programme":8,"title":303,"piName":10,"institution":304,"country":26,"year":13,"amount":14,"abstract":305},"cordis-european-research-council-award-101138971","A novel immuno-oncolytic virus-based dendritic cell therapeutic cancer vaccine","KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)","Following decades of development, therapeutic cancer vaccines are beginning to gain momentum in demonstrating therapeutic effects, and they represent a particularly promising approach. The aim of therapeutic cancer vaccines is to stimulate immunity against tumor antigens, usually through the use of whole cells, peptides, or nucleic acids (i.e. mRNAs). Dendritic cell- (DC) based vaccines represent particularly interesting candidates for therapeutic cancer vaccine products due to their ability to ",{"id":307,"funder":7,"programme":8,"title":308,"piName":10,"institution":309,"country":26,"year":13,"amount":14,"abstract":310},"cordis-european-research-council-award-101156222","A software tool for the Bayesian estimation of Heterogeneous Agent macroeconomic policy models","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","My ERC-CoG project has advanced the methodological frontier in solving and estimating macroeconomic equilibrium models, enabling analysis of the interplay between business cycles and inequality. To transform this innovation into a benefit for society, policymakers must be able to work with models with ease. This will allow them to comprehend how the policies they propose impact both the macroeconomy and income\u002Fwealth distribution. For this purpose, policymakers require a software tool that allow",{"id":312,"funder":7,"programme":8,"title":313,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":314},"cordis-european-research-council-award-101138844","LEAD ADJUVANT PROBE AS A DUAL TECHNOLOGICAL TOOL TO ADVANCE NEXT-GENERATION VACCINE DEVELOPMENT","The goal of ADJUPROBE is to build upon a major discovery made within the ERC-2016-STG-716878 project to validate and valorise our dual synthetic technological tool, moving it forward to boost vaccine efficacy from technical development to commercialisation. We will exploit our lead adjuvant in further preclinical settings in terms of scaled-up production, functional validation, and additional vaccine trials in mice with clinically relevant antigens. In parallel, we will confirm and advance the i",{"id":316,"funder":7,"programme":8,"title":317,"piName":10,"institution":318,"country":38,"year":13,"amount":14,"abstract":319},"cordis-european-research-council-award-101158040","Reprogramming of Tumor Stroma to Enhance Cancer Immunotherapy","INSTITUT PASTEUR","Cancer immunotherapies have shown impressive success in cancer treatment. However, these therapies are limited to certain type of cancers, and success rate is still low. In particular, certain types of solid tumors containing an abundant stroma, which represent a majority of epithelial derived cancer, respond very poorly to immunotherapies. In these tumors, a major challenge for the development of novel cancer immunotherapies is represented by the tumor microenvironment (TME), a highly hypoxic a",{"id":321,"funder":7,"programme":8,"title":322,"piName":10,"institution":323,"country":38,"year":13,"amount":14,"abstract":324},"cordis-european-research-council-award-101157633","Transportable Hyperpolarization for Imaging","UNIVERSITE LYON 1 CLAUDE BERNARD","Over the last five decades, Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) have become indispensable in analytical chemistry and medical diagnostics. Progress in high magnetic fields has elevated resolution and sensitivity, enabling faster data collection at minimal concentrations. However, the sensitivity of magnetic resonance has bounds. Hyperpolarization techniques, particularly Dissolution Dynamic Nuclear Polarization, are gaining attention for enhancing sensitivity. T",{"id":326,"funder":7,"programme":8,"title":327,"piName":10,"institution":223,"country":20,"year":13,"amount":14,"abstract":328},"cordis-european-research-council-award-101137676","Postbiotic Restoration Of the Metabolome Of Moms","Microbial dysbiosis can lead to behavioral changes including aggressive behavior. Mice treated with antibiotics exhibit increased aggression, as do offspring of mothers given antibiotics only during pregnancy or alternatively only when nursing. Promising results from our lab in flies and mice support our hypothesis that such behaviors are partially affected by gut bacteria and associated metabolic compounds. Pregnancy is associated with reduced immune function and women receive antibiotics durin",{"id":330,"funder":7,"programme":8,"title":331,"piName":10,"institution":332,"country":38,"year":13,"amount":14,"abstract":333},"cordis-european-research-council-award-101156045","Wireless Test fixtures to Measure the Dielectric Properties of Materials in RF","INSTITUT POLYTECHNIQUE DE GRENOBLE","RF characterisation of dielectric materials is increasingly an important scientific and commercial activity insofar as even if a very significant effort of the RF community has allowed the development of reliable characterisation solutions, it remains that these techniques rely on RF test fixtures that is heavy to implement, expensive, with a limited field of use (type of materials, frequencies, resolution) and therefore not adapted to the ever-increasing needs of companies, most of which have n",{"id":335,"funder":7,"programme":8,"title":336,"piName":10,"institution":337,"country":50,"year":13,"amount":14,"abstract":338},"cordis-european-research-council-award-101138091","Lightweight Vibration Absorption using Buckling Metamaterials","UNIVERSITEIT VAN AMSTERDAM","Vibrations cause unwanted noise and even failure in many areas, including vehicles such as spacecrafts, road vehicles and trains, sensitive optical or high-tech instruments and machinery. The market size for global vibration control systems was valued at 4.7 billion dollars in 2021 and is expected to expand to 8.1 billion dollars in 20302. This increase in demand is driven by a growing emphasis on the mechanical stability and balancing of industrial machines, which require ever growing precision",{"id":340,"funder":7,"programme":8,"title":341,"piName":10,"institution":342,"country":38,"year":13,"amount":14,"abstract":343},"cordis-european-research-council-award-101152624","Lifting Design Drawings to 3D","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","Building on the outcome of the ERC Starting Grant D3 (ERC-2016-STG 714221), the objective of DLift is to demonstrate how our technology for reconstructing drawings in 3D can streamline the Computer-Aided-Design (CAD) workflow, and to take the first steps in industrializing this technology. Drawing is a fundamental tool of product design. However, while 2D drawings are easily understood by humans, they are currently not interpretable by computers. To confront their ideas with physical reality, de",{"id":345,"funder":7,"programme":8,"title":346,"piName":10,"institution":347,"country":26,"year":13,"amount":14,"abstract":348},"cordis-european-research-council-award-101138171","A 3D-printable biomimetic bone regeneration material","GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER","Critical-size bone defects do not heal spontaneously over the patient’s lifetime and cause substantial individual, societal and economic burden. Current treatment options are hampered by associated complications, poor functional or aesthetic outcomes, a limited availability of tissue for bone grafts, and high financial costs. Worldwide, more than 4 million surgeries per year require bone grafts or substitute materials. Consequently, there is a significant clinical and economic need for novel tre",{"id":350,"funder":7,"programme":8,"title":351,"piName":10,"institution":352,"country":50,"year":13,"amount":14,"abstract":353},"cordis-european-research-council-award-101158067","Building an AI-tool to facilitate the integration, accessibility, and usability of heterogeneous cultural heritage data on medieval manuscripts.","STICHTING RADBOUD UNIVERSITEIT","Data on our cultural heritage hold enormous potential for Europe’s economic growth, for the construction of a more inclusive narrative of its past, and for the future collective identity of its citizens. The biggest obstacle to unlocking that potential is the current lack of integration and interoperability among the countless datasets describing the holdings of European heritage institutions. ManuscriptAI will help remove that obstacle for the data on Europe’s medieval written heritage, manuscr",{"id":355,"funder":7,"programme":8,"title":356,"piName":10,"institution":357,"country":12,"year":13,"amount":14,"abstract":358},"cordis-european-research-council-award-101123484","Towards Shared Accountability: Rethinking the Locus and Scale of Assessment and Improvement in Education","UNIVERSITAT AUTONOMA DE BARCELONA","Accountability has emerged as a central feature of educational governance worldwide. However, the prevailing accountability approach in education, the so-called performance-based accountability (PBA), has led to adverse effects and discomfort among key stakeholders in the education sector. PBA, with its focus on individual schools as primary account providers, intensifies competitive pressures, fosters institutional fragmentation, and often stigmatizes disadvantaged schools. Recognizing these dr",{"id":360,"funder":7,"programme":8,"title":361,"piName":10,"institution":228,"country":26,"year":13,"amount":14,"abstract":362},"cordis-european-research-council-award-101138463","Automated Synthesis of Certifiable Control Software for Autonomous Vehicles","Autonomous driving is a dominant technological theme of the 21st century, with vehicles from various car manufacturers equipped with different levels of autonomy. However, the implementation of safe and reliable control software remains a critical challenge for car manufacturers before fully autonomous vehicles become a reality. The current lack of reliability in autonomous vehicle software is mainly attributed to the absence of formal correctness. Design requirements are not expressed in a form",{"id":364,"funder":7,"programme":8,"title":365,"piName":10,"institution":366,"country":110,"year":13,"amount":14,"abstract":367},"cordis-european-research-council-award-101136845","A Robust, Real-time, and 3D Human Motion Capture System through Multi-Cameras and AI","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","The ability to reliably track 3D human motion in real-time is crucial for a wide range of applications across various fields, such as healthcare, entertainment, industry, and sports. Occupational ergonomics, as the intersection of industry and healthcare, could particularly benefit from such a solution, as recent reports indicate that physical and cognitive ergonomics issues at work contribute to major economic losses in Europe. However, the existing commercial human motion capture (MoCap) syste",{"id":369,"funder":7,"programme":8,"title":370,"piName":10,"institution":25,"country":26,"year":13,"amount":14,"abstract":371},"cordis-european-research-council-award-101158110","Exploiting Cellular Metabolism to Develop the Next Generation of mTOR Inhibitors","The mTOR (mammalian\u002Fmechanistic Target of Rapamycin) kinase, as part of the mTORC1 and mTORC2 protein complexes, is the master controller of cellular and organismal physiology. Dysregulation of mTORC1 activity is tightly linked to human disease and ageing. Consequently, mTOR inhibitors have been tested in various clinical settings, however with little success and limited applicability so far, mainly due to low efficacy or adverse effects, thus highlighting the need for more potent and more speci",{"id":373,"funder":7,"programme":8,"title":374,"piName":10,"institution":375,"country":26,"year":13,"amount":14,"abstract":376},"cordis-european-research-council-award-101158295","Actionable metabolite supplements to improve treatment response in pancreatic cancer","UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF","The prognosis with metastatic pancreatic ductal adenocarcinoma PDAC is simply terrible, especially for those that do not respond to the chemotherapy, which is regarded as the standard therapy in most patients. More than half of the patients are non-responders and eventually pass away within months. It is therefore urgently needed to understand the differences among responder and non-responder patients, to develop alternative therapies that overcome the resistance and potentially further extend t",{"id":378,"funder":7,"programme":8,"title":379,"piName":10,"institution":380,"country":50,"year":13,"amount":14,"abstract":381},"cordis-european-research-council-award-101123166","Tuning Immune T cells for cancer therapy","STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM","Adoptive cell therapy (ACT) recently became an important treatment modality for cancer . Since 2017, several chimeric antigen receptor (CAR)-T cell therapies approved by the FDA\u002FEMA and more are expected to receive approval for clinical use. Currently, more than 250 clinical ACT trials are ongoing. Already in 2021, the market size was >$1 billion and is expected to  grow tremendously to >$25 billion  by 2030. ACT products require extensive ex vivo manipulation and expansion of patient derived T ",{"id":383,"funder":7,"programme":8,"title":384,"piName":10,"institution":385,"country":126,"year":13,"amount":14,"abstract":386},"cordis-european-research-council-award-101158122","Gamma-secretase allosteric modulation as preventive therapy in Alzheimer’s Disease","VIB VZW","The recent advent of therapeutic Aβ-antibodies has validated amyloid plaques as drug targets in Alzheimer’s Disease (AD). They remain expensive, prone to side effects, and clinical benefit is limited. The field needs a safe and cheap drug, preferably a small compound that can be taken orally, and in a preventative way before brain damage has occurred. Despite strong theoretical potential, further clinical development of gamma-secretase allosteric modulators (GAM), is currently hampered by the la",{"id":388,"funder":7,"programme":8,"title":389,"piName":10,"institution":281,"country":38,"year":13,"amount":14,"abstract":390},"cordis-european-research-council-award-101158298","Photosynthetic Activity in Low Micro-Algal Density Suspensions","Photosynthesis is at the intersection of many vexing problems facing humanity, including feeding an ever-increasing population, securing the agricultural economy, replacing fossil fuels with renewable energy, and responding to climate changes. Studying this fundamental process and exploring its functional biodiversity is a crucial necessity. Indeed, photosynthesis is a perfect tool for environmental monitoring in a context of climate changes; it probes in a non-invasive way the physiological sta",{"id":392,"funder":7,"programme":8,"title":393,"piName":10,"institution":394,"country":26,"year":13,"amount":14,"abstract":395},"cordis-european-research-council-award-101158010","STED-enabled super-resolution multimode-fibre based holographic endoscopy for deep-tissue observations of neuronal connectivity","LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V.","Neurological disorders have emerged as a significant global societal burden, exemplified by afflictions like Alzheimer's and Parkinson's, impacting over one billion individuals globally and surpassing the combined economic burden of cancer and diabetes. This has spurred a concerted global effort, with increased support for neuroscience research. These disorders often target deep brain regions and profoundly influence the structural connectivity of neuronal cells within functional circuits. Synap",{"id":397,"funder":7,"programme":8,"title":398,"piName":10,"institution":49,"country":50,"year":13,"amount":14,"abstract":399},"cordis-european-research-council-award-101157112","Versatile Integrated Brillouin-Kerr Frequency Combs for On-Chip Photonic Systems","An ultra-stable, low-noise optical frequency comb seamlessly integrated into a compact chip-scale form factor has the potential to revolutionize precision measurements, radiofrequency and optical communications, and quantum technologies.  Today’s chip-scale frequency combs can achieve stable, phase-locked and broadband emission, but they suffer from high noise that blocks the pathway towards more stringent applications such as microwave photonics.  Brillouin optomechanics, a nonlinear optical ef",{"id":401,"funder":7,"programme":8,"title":402,"piName":10,"institution":403,"country":110,"year":13,"amount":14,"abstract":404},"cordis-european-research-council-award-101137707","TIMELAPSE. A VR application for speeding up time passage during chemotherapy","UNIVERSITA DEGLI STUDI DI MILANO","Chemotherapy can involve lengthy treatment sessions, lasting up to several hours. Such a duration, spent in an overly medicalized setting, can induce in the patients a monopolizing focus on their pathology, which leads to a substantial decrease in their mental well-being.One way to alleviate the impact of long chemotherapy sessions would be accelerating subjective time passage as perceived by the patients, therefore making the treatment seemingly end more quickly.Stemming from the ERC Advanced G",{"id":406,"funder":7,"programme":8,"title":407,"piName":10,"institution":309,"country":26,"year":13,"amount":14,"abstract":408},"cordis-european-research-council-award-101123148","Development of a biomimetic prototype to reduce microplastics emissions","Within ERC Starting Grant Mech-Evo-Insect, we have identified a new principle to filter small particles such as microplastics from water. This filtration principle is used in a variety of organisms but one particular example, the filtration used by suspension feeding fish, is promising to filter diverse waste waters. The idea of the PoC SuspensionFlow is to transfer this principle to a filtration unit which can be used in all household washing machines to reduce global microplastics emissions. S",{"id":410,"funder":7,"programme":8,"title":411,"piName":10,"institution":412,"country":12,"year":13,"amount":14,"abstract":413},"cordis-european-research-council-award-101158161","Diapause-mediated cattle embryo storage","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","Embryo transfer is a key enabling technology in the farming industry, playing an essential role in expanding genetic improvement and its associated economic and environmental benefits. The procedure requires estrous synchronized recipient animals, which are often not available at the same time and location than the embryos. The only solution available to circumvent this problem is to arrest embryo development by cryopreservation, a technique that allows embryo storage but reduces embryo viabilit",{"id":415,"funder":7,"programme":8,"title":416,"piName":10,"institution":294,"country":50,"year":13,"amount":14,"abstract":417},"cordis-european-research-council-award-101157882","Combine measures of social assistance benefit indicators to correct for measurement error","Aim: To break new ground in the field of official statistics, COMBINE produces error-corrected figures on (1) the number of individuals receiving social assistance benefit at a given point in time and (2) the transition rate out of social assistance between two points in time. Background: Social assistance benefits are an important pillar of the welfare state. Policy making on social assistance benefits is based on official statistics that are produced by National Statistical Institutes with the",{"id":419,"funder":7,"programme":8,"title":420,"piName":10,"institution":25,"country":26,"year":13,"amount":14,"abstract":421},"cordis-european-research-council-award-101158346","Membrane Micro-Compartments","More than two-thirds of all described drug targets are membrane proteins, but only for a small fraction of these hydrophobic proteins the structure is currently known. Membrane proteins are inherently challenging to produce and analyze. Consequently, in pre-clinical investigations their mechanism and drug interactions are often only derived from purified truncated parts of these proteins, taken out of their native biological context. Lacking the effects of surrounding membrane components, conclu",{"id":423,"funder":7,"programme":8,"title":424,"piName":10,"institution":425,"country":426,"year":13,"amount":14,"abstract":427},"cordis-european-research-council-award-101158262","Modulating feeding behavior in obesity: from brain lesions to non-invasive brain stimulation targets","FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD","PT","Altered feeding behaviors impair physical and psychosocial health and may lead to overweight or obesity. Obesity is a major global health challenge but current treatments are either ineffective in the long-term or carry important risks. Hence, novel therapeutic approaches are needed. The main ERC StG aims to explore the neural basis of eating patterns by exploring post-ingestive reinforcement of food-seeking behavior. In that context, we are studying the contribution of gut-brain communication t",{"id":429,"funder":7,"programme":8,"title":430,"piName":10,"institution":431,"country":20,"year":13,"amount":14,"abstract":432},"cordis-european-research-council-award-101158160","Curing ovarian cancer through autoantibody-based therapy","WEIZMANN INSTITUTE OF SCIENCE","Ovarian cancer (OC) is a malignant tumor with poor prognosis and limited treatment options, responsible for 4.4% of cancer-related mortality in women. There is an urgent need for innovative therapeutic approaches for OC. Antibody drug conjugates (ADCs) represent one of the most promising therapeutic approaches, but their efficacy has been hindered by identification of suitable tumor-associated antigens. For example, ADCs targeting MUC16, the best diagnostic marker for OC, have thus far failed in",{"id":434,"funder":7,"programme":8,"title":435,"piName":10,"institution":436,"country":12,"year":13,"amount":14,"abstract":437},"cordis-european-research-council-award-101123120","Virtual Embodied Reminiscence Therapy in Extended Reality","UNIVERSITAT DE BARCELONA","VERTEX is a proof of concept project that aims to use virtual reality (VR) to improve the well-being of older adults. The project is based on the idea that psychological factors play a key role in age-related deterioration and that older adults' attitudes towards aging may be a significant predictor of physical and cognitive frailty. Participants will experience scenarios and events from their youth, such as being in a 1970s living room. They will be transported to memorable historical events fr",{"id":439,"funder":7,"programme":8,"title":440,"piName":10,"institution":294,"country":50,"year":13,"amount":14,"abstract":441},"cordis-european-research-council-award-101138650","Learning to Donate","Background. Without blood donors, there are no blood products to transfuse and no plasma for pharmaceutical drug production. Four million patients are annually treated with blood derived products in Europe alone, given by voluntary donors. Yet, as little as 2-3% of the population is registered as blood donor and donor numbers are decreasing during the last decades. At the same time, the demand for specific blood products is increasing. Hence, it is crucial that a countrys donor pool is sufficien",{"id":443,"funder":7,"programme":8,"title":444,"piName":10,"institution":445,"country":110,"year":13,"amount":14,"abstract":446},"cordis-european-research-council-award-101138301","PROstate Focal THerapy","NEEDLEYE ROBOTICS SRL","The PROFTH project aims at developing the robotics and AI technologies to enable focal therapies for prostate cancer (PCa) using the robotic positioned developed during the ERC-PoC PROST. PCa therapy is lagging about 10 years from e.g. kidney and breast therapies, that has shifted from invasive surgery to percutaneous ablation of the tumour. Several trials are acquiring the clinical evidence to support the shift from radical prostatectomy to PCa focal therapy, considering the multifocal aspect o",{"id":448,"funder":7,"programme":8,"title":449,"piName":10,"institution":218,"country":26,"year":13,"amount":14,"abstract":450},"cordis-european-research-council-award-101155827","High-resolution weather observations East of Dakar (DakE)","High-resolution automatic weather monitoring system east of Dakar (DakE) will probe the internal structure and dynamics of tropical mesoscale convective systems (MCS) and design a novel methodology for flood and storm early warning.",{"id":452,"funder":7,"programme":8,"title":453,"piName":10,"institution":454,"country":110,"year":13,"amount":14,"abstract":455},"cordis-european-research-council-award-101157307","MYokinetic Towards Innovation","SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA","MYTI - MYokinetic Towards Innovation, aims at boosting the clinical translation of the technology developed within the ERC funded project MYKI - A Bidirectional MyoKinetic Implanted Interface for Natural Control of Artificial Limbs. Core of the project is an innovative human-machine-interface for the control of upper-limb prostheses, which relies on a multitude of permanent magnets implanted within the residual muscles. Briefly, external electronic components acquire the magnetic field of the ma",{"id":457,"funder":7,"programme":8,"title":458,"piName":10,"institution":459,"country":126,"year":13,"amount":14,"abstract":460},"cordis-european-research-council-award-101158037","Distributed Coordinated Access Point","UNIVERSITEIT GENT","In this project, we aim to validate a low-cost Cell Free massive MIMO solution for ultra-reliable and low-latency wireless communication based on Wi-Fi technology. Our solution, called DCAP or Distributed Coordinated Access Point, is enabled by integrating distributed customized Wi-Fi 6 access points with the synchronous fronthaul technology developed in ERC ATTO. The following research innovations will be explored and demonstrated:1. Accurate time synchronization of the distributed APs with the",{"id":462,"funder":7,"programme":8,"title":463,"piName":10,"institution":65,"country":20,"year":13,"amount":14,"abstract":464},"cordis-european-research-council-award-101157514","Flow Controlled Prosthetic Heart Valves","Prosthetic Heart Valves (HV), both biological (BHV) and mechanical (MHV), have improved the survival rate and the quality of life of valvular heart-disease patients over the last six decades. While BHVs, taken from animal tissue, show improved hemodynamics, their durability is limited, whereas MHVs can last a patient's entire lifetime but require lifetime anticoagulation medication to reduce thrombotic complications. Future Polymeric HVs (PHV) hold the potential for enhanced durability compared ",{"id":466,"funder":7,"programme":8,"title":467,"piName":10,"institution":468,"country":44,"year":13,"amount":14,"abstract":469},"cordis-european-research-council-award-101132305","AdaptiveTarget: Accessing haplotype variation at complex loci  with optimized targeting and adaptive sampling","STOCKHOLMS UNIVERSITET","Genetic variation at resistance loci is crucial for sustained crop yield, given the challenges and increased pest and pathogen pressures resulting from a warming climate. Despite recent advances in massively parallel sequencing, disease resistance loci and other complex genomic regions of great practical, economical and scientific importance remain challenging to study. The severe limitations of current methods pose a major problem for fully understanding and harnessing genetic variation for cro",{"id":471,"funder":7,"programme":8,"title":472,"piName":10,"institution":228,"country":26,"year":13,"amount":14,"abstract":473},"cordis-european-research-council-award-101155853","Physical Unclonable anticounterfeit tags using Nanotechnology","The problem: 119 billion EUR worth of counterfeit and pirated goods were sold in the EU in 2022 (Europol\u002FEUIPO). Counterfeiting of goods remains a challenge for our society, increasingly so in a globalised world with long supply chains. Concurrently, the market for sensitive goods, such as medicine has also increased, further exemplifying the need for anti-counterfeit measures. The WHO estimates ~ 100,000 children under five die annually from taking counterfeit pneumonia medication. Current anti",{"id":475,"funder":7,"programme":8,"title":476,"piName":10,"institution":477,"country":12,"year":13,"amount":14,"abstract":478},"cordis-european-research-council-award-101157562","The Mitochondrial Paradox: Embracing Mitohormesis for Improved Metabolic and Aging Health","FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER","Obesity and aging are two of the most important health challenges facing our societies in the 21st century. However, there are currently no effective therapeutic approaches to mitigate the growing obesity pandemic or to promote healthy aging. Therefore, it is essential to explore new research frontiers in order to develop more effective and safer strategies. Mitohormesis, the process by which induced mitochondrial stress can trigger beneficial health effects, has emerged as a promising area of s",{"id":480,"funder":7,"programme":8,"title":481,"piName":10,"institution":482,"country":26,"year":13,"amount":14,"abstract":483},"cordis-european-research-council-award-101156469","Hyperspectral Fiber Photometry for Flexible, Multiplexed Optical Measurements of Brain Function","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","Fiber photometry allows the activity of molecularly defined neuronal populations to be measured in freely behaving animals. The method is based on an implanted optical fiber through which fluorescent genetically encoded indicators of cellular activity, metabolites or signaling molecules can be monitored and is widely used in neuroscience research. However, conventional photometry systems are not flexible and typically limited to a fixed configuration of one or two readout channels. We will devel",{"id":485,"funder":7,"programme":8,"title":486,"piName":10,"institution":366,"country":110,"year":13,"amount":14,"abstract":487},"cordis-european-research-council-award-101155938","RObot traiNing INdependence","RONIN aims to develop a training toolkit, embedded in a robot-assisted training setup, for supporting adolescents with developmental disabilities (DDs) in achieving independent adult life. DDs hinder access to formal education for about 4 million children in Europe, which, in consequence, compromises their independence later in life. This poses a huge challenge for the affected individuals, their families, and for society. One of the major issues that impedes achieving independence by individual",{"id":489,"funder":7,"programme":8,"title":490,"piName":10,"institution":491,"country":110,"year":13,"amount":14,"abstract":492},"cordis-european-research-council-award-101158039","Instrumented human stem cells to see more during high throughput screening in drugInstrumented human stem cells to see more during high throughput screening in drug discovery and regenerative medicine","UNIVERSITA DEGLI STUDI DI PAVIA","In hiPSCmore (read hiP-See-More), my team and I will engineer fluorescent sensors in the DNA of human induced pluripotent stem cells (hiPSC) so we can “See More” during high-throughput imaging screenings (imHTS) for drug discovery and regenerative medicine.Since hiPSCs can differentiate in most cell types in the human body, they are the ideal cell source for more predictively screening therapies. Yet, hiPSCs are expensive to maintain and require external reagents to visualize pathophysiological ",{"id":494,"funder":7,"programme":8,"title":495,"piName":10,"institution":125,"country":126,"year":13,"amount":14,"abstract":496},"cordis-european-research-council-award-101158183","Proof of Concept Prototype for Matching Applications on BELFORT Hardware","The world has become one global village, strongly connected by the internet. Users, applications, and companies produce huge amounts of data. This data is mostly very private (health, financial, commercial data, etc.), requiring organizations to encrypt the data when storing or transmitting it. In Europe, fortunately, our GDPR regulations are very strict about this.  On the other hand, many legitimate applications want to inspect or match the data with some database. Examples are matching encryp",{"id":498,"funder":7,"programme":8,"title":499,"piName":10,"institution":190,"country":191,"year":13,"amount":14,"abstract":500},"cordis-european-research-council-award-101138593","Decellularised Extracellular Carpets for the Innovative Production of Human Engineered Replicates","The major roadblock in the commercialisation of cell-derived products is the prolonged ex vivo culture period required to develop them. Macromolecular crowding (MMC), a biophysical phenomenon that increases the kinetics of biochemical reactions and biological processes by several orders of magnitude, allows for the accelerated development of cell-derived products. This project will exploit MMC in the development of cell-derived products in 2 technical and 3 commercial work-packages, increasing t",{"id":502,"funder":7,"programme":8,"title":503,"piName":10,"institution":281,"country":38,"year":13,"amount":14,"abstract":504},"cordis-european-research-council-award-101147066","Development of a non-invasive medical device to measure the skin biomechanical properties: assessment of the commercial feasibility","Skin pathologies including wounds, scars and tumors represent important public health issues. (e.g. melanoma is the first cancer in terms of increasing frequency). Moreover, skin firmness is an essential property aimed by cosmetic products. However, skin assessment methods remain based on empirical considerations and it is still difficult to determine the skin biomechanical properties, which prevents developing a personalized medicine approach. Such medical device is needed by the physicians to ",{"id":506,"funder":7,"programme":8,"title":507,"piName":10,"institution":508,"country":197,"year":13,"amount":14,"abstract":509},"cordis-european-research-council-award-101158077","FastML: Efficient and Cost-Effective Distributed Machine Learning","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","Deep Learning is an area of massive progress, with myriad applications and significant industry adoption. A key enabler of its progress is the ability to train large, highly-accurate Deep Neural Networks (DNNs) in a distributed fashion, across tens to thousands of different computational nodes. Yet, DNN training at scale poses severe challenges to standard paradigms in distributed computing; existing distributed training approaches and their practical implementations, via training libraries such",{"id":511,"funder":7,"programme":8,"title":512,"piName":10,"institution":150,"country":110,"year":13,"amount":14,"abstract":513},"cordis-european-research-council-award-101158332","Engineered multi-well platforms integrating biochemical and biophysical cues for the functional maturation and electrophysiological monitoring of cardiac tissue models.","Cardiovascular diseases are the major cause of mortality worldwide, making the demand for new therapies an urgent need. Additionally, unexpected cardiac adverse effects are the leading causes of discontinuation of clinical trials and withdrawal of drugs from the market. Such issues could be addressed by relevant in vitro human cardiac tissue models reproducing in vivo-like pharmacological response. However, most in vitro cardiac tissue models developed so far have been limited by complex design ",{"id":515,"funder":7,"programme":8,"title":516,"piName":10,"institution":517,"country":26,"year":13,"amount":14,"abstract":518},"cordis-european-research-council-award-101158076","A Deductive Verifier for Probabilistic Programs","RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN","Program correctness is a central problem in computer science. Code inspection and testing can reveal many program bugs, but subtle errors need a rigorous analysis. A fully automated analysis is impossible: deciding whether a program terminates on a given input is undecidable.  Thanks to unremitting developments in program verification and incredible advancements in satisfiability checking, program verification is nowadays supported by software tools in industrial practice. Meta and Amazon Web Se",{"id":520,"funder":7,"programme":8,"title":521,"piName":10,"institution":517,"country":26,"year":13,"amount":14,"abstract":522},"cordis-european-research-council-award-101123087","Large-Scale Electrosynthesis of Borylated Azines","'The Nobel prize-winning Suzuki-Miyaura cross-coupling involves the palladium-catalysedcoupling of a borylated molecule with an aryl halide and is the 2nd most used process by thepharmaceutical sector.Azines are small-molecules integral to discover and manufacture pharmaceuticals andagrochemicals. Using azines in Suzuki-Miyaura cross-coupling reactions represents the idealsolution to introduce these important motifs in discovery molecules but here is where theproblems come:1. There is currently ",{"id":524,"funder":7,"programme":8,"title":525,"piName":10,"institution":526,"country":38,"year":13,"amount":14,"abstract":527},"cordis-european-research-council-award-101138078","Subcutaneous delivery of theranostic cell-based therapies","GCS INSTITUT DE CANCEROLOGIE STRASBOURG EUROPE","This PoC project seeks to develop a simple-to-implement self-assembled and injectable hydrogel material for the controlled co-delivery of our simili-CAR NK cells and stimulatory cytokines to improves treatment of both solid and liquid tumors. Similar to biologics delivery where monoclonal antibodies (mAbs) are commonly administered by IV infusion due to regulatory criteria favoring such route which had limited confounding factors, the IV administration remains responsible for some over costs and",{"id":529,"funder":7,"programme":8,"title":530,"piName":10,"institution":531,"country":532,"year":13,"amount":14,"abstract":533},"cordis-european-research-council-award-101138710","'It yet remains to see...' - Hybrid electrochemical energy storage system of high power and improved cycle life","POLITECHNIKA POZNANSKA","PL","This project focuses on the electric energy storage and offers research on novel type of hybrid electrochemical capacitor (HEC) thatstores the energy quickly (due to high power), efficiently (due to reversible interactions inside) and demonstrates the satisfactoryperformance over thousands of charging\u002Fdischarging cycles.Innovative concept of redox-active electrolyte as a component that allows for full insertion of the negative electrode will beresearched. A comprehensive study, including several",{"id":535,"funder":7,"programme":8,"title":536,"piName":10,"institution":281,"country":38,"year":13,"amount":14,"abstract":537},"cordis-european-research-council-award-101123037","Quantum Simulator with Hot Atomic Vapors","In the context of the ongoing development of novel quantum technologies, includingquantum sensors, quantum communication, quantum simulators and quantum computing,some devices are mature without resorting to the powerful but fragile entanglement between qubits.Exploiting the wave nature of devices, photons often play an important role. In order to enlarge thepotential of photonic devices, controlled atom-photon interactions will be pushed to new limits in orderto build analog and digital wave si",{"id":539,"funder":7,"programme":8,"title":540,"piName":10,"institution":357,"country":12,"year":13,"amount":14,"abstract":541},"cordis-european-research-council-award-101138151","Healthy Soil for Urban Agriculture through Nutrient and Carbon Circularity","Many policies promote urban and peri-urban agriculture (UA) through circularity of nutrients to increase food autonomy, minimize food losses, and reduce environmental impacts associated to transport, mineral fertilizer production, and waste management. Yet up to date most EU cities have low local crop production, and although they generate vast volumes of nutrient-rich waste, nutrient recovery through composting and wastewater treatment to substitute mineral fertilizer for application in UA is s",{"id":543,"funder":7,"programme":8,"title":544,"piName":10,"institution":545,"country":26,"year":13,"amount":14,"abstract":546},"cordis-european-research-council-award-101149200","Photonic Vector Network Analyzers","TECHNISCHE UNIVERSITAT DARMSTADT","The deployment of 5G networks and the upcoming deployment of 6G in the next decade is essential to advance wireless communication for keeping pace with modern data hunger. 6G will incorporate first channels in the Terahertz domain (100 GHz -10 THz), however, terahertz technology in communication applications has a main bottle neck: the lack of powerful sources and versatile components. In order to engineer these towards maturity, sophisticated characterization tools are required to identify desi",{"id":548,"funder":7,"programme":8,"title":549,"piName":10,"institution":550,"country":50,"year":13,"amount":14,"abstract":551},"cordis-european-research-council-award-101158287","Multianalyte Continuum Nanopores Sensing","RIJKSUNIVERSITEIT GRONINGEN","Diagnostic limitations in healthcare form a major societal challenge, especially in the case of heart failure. More than 15 million Europeans suffer from heart failure, with a projected increase of up to 33% in heart failure patients globally by 2060. An important instrument for better diagnoses of heart failure comes from natriuresis-guided therapy, offering potential for personalized treatment. Monitoring natriuresis through urinalysis via Point of Care Testing (POCT) helps manage severe heart",{"id":553,"funder":7,"programme":8,"title":554,"piName":10,"institution":555,"country":12,"year":13,"amount":14,"abstract":556},"cordis-european-research-council-award-101158233","Reliable and scalable procedures for the isolation and loading of extracellular vesicles","UNIVERSIDAD DE ZARAGOZA","Exosome-based therapies are among the hottest topics in biomedical research, driven by the unique properties of exosomes regarding stability, low immunogenicity, prolonged circulation and especially, selective targeting. In 2022, over 50 clinical trials using exosomes for therapy were under way, in diseases ranging from cancer to diabetes to central nervous system disorders. However, both current research on exosomes and their future translation into clinical therapies are hindered by two signif",{"id":558,"funder":7,"programme":8,"title":559,"piName":10,"institution":267,"country":197,"year":13,"amount":14,"abstract":560},"cordis-european-research-council-award-101158345","Epigenetic profiling of menstrual blood for precision cancer detection and prevention","Cancer has overtaken cardiovascular disease as the number one cause of mortality in high income countries, cancer incidence is increasing across the globe. Morbidity and mortality from womens cancers, particularly breast, ovarian, and endometrial cancers, follow or exceed these general trends in cancer incidence. Tackling this growing cancer burden requires a multifactorial approach including understanding the fundamental drivers of cancer development; improving methods for detecting earlier tho",{"id":562,"funder":7,"programme":8,"title":563,"piName":10,"institution":564,"country":26,"year":13,"amount":14,"abstract":565},"cordis-european-research-council-award-101123255","Low-noise, rapid and ultrabroadband terahertz time-domain ellipsometry enabled by spintronic terahertz emitters","FREIE UNIVERSITAET BERLIN","Electromagnetic radiation in the terahertz (THz) frequency range (0.3-30 THz) is a powerful tool for material spectroscopy and characterization in a contact-free, non-ionizing and non-destructive way. An essential application is the contact-free measurement of the complex-valued reflectivity and, ideally, refractive index of materials. Such knowledge is essential in condensed-matter research (for characterization of, e.g., the conduction-electron concentration and scattering in semiconductors, o",{"id":567,"funder":7,"programme":8,"title":568,"piName":10,"institution":337,"country":50,"year":13,"amount":14,"abstract":569},"cordis-european-research-council-award-101138119","Targeted Respiratory Drug Delivery by Tribo Charged Sprays","The main purpose of this proposal is to develop a radically new technology for very precisely delivering medicine to the human body. Targeted deposition of drug formulations to the lungs exhibits great promise in several treatments, e.g. siRNA treatment against lung cancer or mRNA vaccination against COVID-19. This requires oral and nasal inhalation for which spray pumps and nebulizers are widely used to transform an aqueous formulation into a soft mist spray. However producing the necessary dro",{"id":571,"funder":7,"programme":8,"title":572,"piName":10,"institution":99,"country":50,"year":13,"amount":14,"abstract":573},"cordis-european-research-council-award-101138075","Polymer pRobes fOr a VISual prOsthesis","Approximately forty million people across the world are blind, a condition with serious consequences for a persons autonomy. Restoration of visual function in blind individuals is an important scientific goal with large societal benefits. In a large fraction of blind patients, the connection between the eye and the brain has degenerated so that restoration of a rudimentary form of vision can only be achieved in pathways downstream from the retina, like the visual cortex. PROVISO tests the feasib",{"id":575,"funder":7,"programme":8,"title":576,"piName":10,"institution":577,"country":12,"year":13,"amount":14,"abstract":578},"cordis-european-research-council-award-101123298","Simulating the effects of low-carbon investments in electricity markets","UNIVERSIDAD CARLOS III DE MADRID","NextENERGEIA plans to develop and test a proof-of-concept prototype of an analytical tool for simulating the social and private impact on power markets of low-carbon investments (renewable energies, energy storage, electric vehicles, and hydrogen production). The tool would shed light on issues central to the energy transition’s success, making it precious for regulators, policymakers, energy-intensive consumers, and energy firms. In particular, the tool would be instrumental in informing the cu",{"id":580,"funder":7,"programme":8,"title":581,"piName":10,"institution":70,"country":12,"year":13,"amount":14,"abstract":582},"cordis-european-research-council-award-101157669","GenomeDia: a personalized medicine tool for diabetes","Diabetes Mellitus affects nearly 600 million people worldwide. It is a major cause of premature death, blindness, end stage kidney disease, and limb amputation.  However, it is not a single disease. Most patients are catalogued as type 2 diabetes, which is itself highly heterogeneous, while others have autoimmune type 1 diabetes. Genetic testing is currently able to define the precise cause of diabetes in a small group of young patients, although the  categorization of diabetes subtypes is in mo",{"id":584,"funder":7,"programme":8,"title":585,"piName":10,"institution":586,"country":26,"year":13,"amount":14,"abstract":587},"cordis-european-research-council-award-101158249","Harnessing a novel CRISPR nuclease for programmable counterselection in human cells","HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH","CRISPR technologies have revolutionized genome editing in medicine, agriculture, biotechnology, and life-sciences research with their ability to generate virtually any DNA edit at any genomic site in any organism. However, editing frequencies can be restrictively low, requiring extensive screening to identify cells harboring desired edits. What remains elusive is a way to greatly boost the frequency of editing. While characterizing CRISPR-Cas systems, bacterial defense systems and the source of ",{"id":589,"funder":7,"programme":8,"title":590,"piName":10,"institution":591,"country":126,"year":13,"amount":14,"abstract":592},"cordis-european-research-council-award-101158056","Gut HORMOne stimulating CAPSules for the treatment of gastrointestinal metabolic disorders","UNIVERSITE CATHOLIQUE DE LOUVAIN","HormoCaps will help us demonstrate the viability as a commercial product of a dual-action drug delivery system which synergizes its own biological effect and that of the encapsulated bioactive molecule for the oral delivery of peptides. This would represent an alternative to current oral incretin-based treatments for gastrointestinal metabolic disorders. In HormoCaps, we will (i) demonstrate the translational feasibility of our strategy; (ii) evaluate the capacity of the formulation to simultane",{"id":594,"funder":7,"programme":8,"title":595,"piName":10,"institution":596,"country":50,"year":13,"amount":14,"abstract":597},"cordis-european-research-council-award-101158377","Hyper-Realistic Models for Hands-On  Surgical Training  in Non-human Primate Biomedical Research","TILBURG UNIVERSITY- UNIVERSITEIT VAN TILBURG","The PRISM project addresses critical challenges in neurosurgical training involving non-human primates (NHPs) within the framework of the 3Rs (Replacement, Reduction, Refinement) endorsed by the EU. NHPs are indispensable models in biomedical research, particularly in neurosciences, due to their close phylogenetic relationship with humans. However, invasive procedures on NHPs, including cranial surgeries and targeted ablations, pose ethical dilemmas and require highly skilled personnel. This pro",{"id":599,"funder":7,"programme":8,"title":600,"piName":10,"institution":601,"country":197,"year":13,"amount":14,"abstract":602},"cordis-european-research-council-award-101138959","Archaea for Human Health","UNIVERSITAT WIEN","Beside Bacteria and fungi, Archaea, the third domain of life have been described as a stable component of the human microbiome. Yet, only few archaea have so far been isolated from humans.The project aims to demonstrate that a fundamentally new product, derived from archaea, revolutionizing current standards of treatments for human health, can be developed from our initial breakthrough achievement, the cultivation of these archaea. The benefits of using archaea derived from human bodies, promise",{"id":604,"funder":7,"programme":8,"title":605,"piName":10,"institution":606,"country":26,"year":13,"amount":14,"abstract":607},"cordis-european-research-council-award-101158022","Quantum Tensor Engine","TECHNISCHE UNIVERSITAET MUENCHEN","Quantum computers harness fundamental aspects of quantum behavior to drive exponential increases in the speed with which certain computations can be performed. They have potentially a tremendous long-term impact in areas such as quantum-many body physics and material science, and further afield in machine learning. The quantum many-body problems studied by condensed matter physicists are perhaps the most likely to yield early demonstrations of this potential. However, current and near-term inter",{"id":609,"funder":7,"programme":8,"title":610,"piName":10,"institution":611,"country":38,"year":13,"amount":14,"abstract":612},"cordis-european-research-council-award-101138640","Live imaging module for organoids","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","The increased use of organoids (22% growth rate market) creates a new need: methods of rapid high throughput screening of the organoids for quality control in the case where they are to be used as graft tissues or in drug screening trials, while at the same time not damaging the organoids so that they may be used for graft, or followed up long term for therapy efficacy evaluation or disease modeling applications. Current imaging methods for organoids do not meet this need as they are invasive an",{"id":614,"funder":7,"programme":8,"title":615,"piName":10,"institution":616,"country":26,"year":13,"amount":14,"abstract":617},"cordis-european-research-council-award-101123567","Agile Ultra-Scale Communications Using  Optical Arbitrary Waveform Generation and Measurement","KARLSRUHER INSTITUT FUER TECHNOLOGIE","TeraGEAR aims at exploring and verifying the innovation potential of a novel class of optical signal-processing systems that might be of transformative impact to optical communications. On a technical level, the project builds upon novel schemes for optical arbitrary waveform generation and measurement (OAWG\u002FOAWM) that combine advanced photonic integrated circuits (PIC) with chip-scale frequency comb sources and that can address two key challenges of optical communications: The testing and chara",{"id":619,"funder":7,"programme":8,"title":620,"piName":10,"institution":621,"country":12,"year":13,"amount":14,"abstract":622},"cordis-european-research-council-award-101158283","A Novel Antibody-Drug Conjugate for Targeting Tumor-Associated Macrophages in Solid Tumors","ADAPTAM THERAPEUTICS SL","The project is focused on the development of a groundbreaking Antibody-Drug Conjugate (ADC) specifically designed for macrophage depletion in the Tumor Microenvironment (TME). With a primary focus on breast cancer and solid tumors, this initiative represents a paradigm shift in cancer therapeutics.The presence of Tumor-Associated Macrophages (TAMs) in the TME has been identified as a significant factor in tumor progression and immune evasion. Our proposed ADC will directly target these macrophag",{"id":624,"funder":7,"programme":8,"title":625,"piName":10,"institution":366,"country":110,"year":13,"amount":14,"abstract":626},"cordis-european-research-council-award-101157871","Enabling efficient cell engineering leaving gene-expression BURden OUT for cell therapies and biopharmaceutical industry","Mammalian cell engineering has emerged as a new ground-breaking modality for the development of cell based therapies to treat several hard-to-cure diseases, including cancer (T cell-based immunotherapies) and to produce molecule with diagnostic and therapeutic applications such as monoclonal antibodies (mAbs), that are now a dominant product class in the biopharmaceutical industry.  However, the pipeline for efficient design-test-commercialization of the product is long and expensive, even more ",{"id":628,"funder":7,"programme":8,"title":629,"piName":10,"institution":431,"country":20,"year":13,"amount":14,"abstract":630},"cordis-european-research-council-award-101146837","Enhancing Industrial Cultivation:  A Breakthrough Approach Using Methylated Compounds to Expedite Microbial Growth","Accelerating Microbial Cultivation through Lag Phase Shortening using Methylated CompoundsIndustries reliant on microbial cultivation face high production costs, with the cultivation process accounting for 20-40% of the total. However, conventional strategies often overlook the lag phase, an early growth phase in which bacteria do not grow that significantly elongates the cultivation process and impacts production costs.Recent findings arising from our ERC-funded research, reveal a ground-breaki",{"id":632,"funder":7,"programme":8,"title":633,"piName":10,"institution":591,"country":126,"year":13,"amount":14,"abstract":634},"cordis-european-research-council-award-101157974","Developing an Abductive Coding Analysis Toolkit","In qualitative data analysis oriented towards theory-building, many data analysts anchor their methodological approach  explicitly or not  in grounded theory. However, as research in teams develops, handling larger amounts of qualitative data enabled by technological developments, grounded theorys principles are increasingly at odds with current practices; and analysts of qualitative data are left relying on coding procedures that do not match their realities. Following a burgeoning literature a",{"id":636,"funder":7,"programme":8,"title":637,"piName":10,"institution":638,"country":110,"year":13,"amount":14,"abstract":639},"cordis-european-research-council-award-101158288","Early Inflammatory Signatures of IPMN Progression","UNIVERSITA VITA-SALUTE SAN RAFFAELE","Pancreatic Ductal Adenocarcinoma (PDAC) is a lethal cancer with rising global incidence and poor survival rates. Early PDAC diagnosis is hampered by non-specific symptoms and by the absence of reliable early biomarkers. On the other hand, intraductal papillary mucinous neoplasms (IPMNs), precursor lesions of PDAC, are commonly found during abdominal imaging. IPMN management lacks consensus, leading to inefficient decisions decisions on empirical assessments of high-risk stigmata (HRS) and worris",{"id":641,"funder":7,"programme":8,"title":642,"piName":10,"institution":643,"country":26,"year":13,"amount":14,"abstract":644},"cordis-european-research-council-award-101157249","Next Generation Chiral Fluorine Groups for Molecular Design","UNIVERSITAET MUENSTER","Fluorinated motifs have enormous societal relevance due to their ubiquity across the pharmaceutical, agrochemical and materials science sectors. These essential structural components feature prominently in the World Health Organization’s (WHO) list of essential medicines, and contribute to global food supplies by optimising the performance of many key agrochemicals. Similarly, our reliance on (polyfluorinated) materials ranging from non-stick Teflon® through to smart materials underscores the ve",{"id":646,"funder":7,"programme":8,"title":647,"piName":10,"institution":459,"country":126,"year":13,"amount":14,"abstract":648},"cordis-european-research-council-award-101137438","Using Topology To Revolutionize Atrial Tachycardia Treatment","Atrial tachycardia (AT) is a prevalent form of supraventricular tachycardia that can have detrimental impacts on a person's health. The complexity of anatomical reentry patterns and unclear nomenclature hinders precise diagnosis of AT and makes optimal treatment challenging and error prone. Suboptimal treatment can result in severe outcomes such as heart failure, stroke, and pacemaker implantation due to overablation-induced atrial dysfunction. In this proposal, we introduce a diagnostic tool ca",{"id":650,"funder":7,"programme":8,"title":651,"piName":10,"institution":652,"country":26,"year":13,"amount":14,"abstract":653},"cordis-european-research-council-award-101123131","3D screening system to cultivate tissue and automatically stimulate and quantify its mechanical properties","GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS","The way from potential drug candidates to clinically approved new medication is long and expensive. To improve this, we will provide the TissMec system that can create 3D human tissue while providing an automated and scalable way to quantify potential problems of drugs and other compounds of interest. Our TissMec system can not only measure the force generation of muscles and other contractile tissue but also continuously determine the viscoelastic tissue properties while mimicking mechanical si",{"id":655,"funder":7,"programme":8,"title":656,"piName":10,"institution":657,"country":20,"year":13,"amount":14,"abstract":658},"cordis-european-research-council-award-101158251","Multiplexed microRNA detection platform for early diagnosis and patient management","TEL AVIV UNIVERSITY","Early detection of disease on a population scale (screening) relies on highly sensitive testing, able to detect early molecular changes, coupled with cost-effectiveness that enables economic access to such testing at scale.The MiRACLE project addresses these challenges by combining a breakthrough optical sensing approach for single-molecule detection with creative biochemistry and computation. The ground-breaking goal of this research proposal is to develop a robust diagnostic platform capable o",{"id":660,"funder":7,"programme":8,"title":661,"piName":10,"institution":662,"country":110,"year":13,"amount":14,"abstract":663},"cordis-european-research-council-award-101138232","Advanced ingestibles for probing the nexus between gastrointestinal functions and physical\u002Fmental well-being in animals and humans","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","Expanding on the eHONESTY ERC project about the link between body and moral decisions, the DeepDive PoC proposal aims to explore the neglected role of deep-body signals in modulating physical\u002Fmental health in humans and animals through the radically new approach of using ingestibles for mapping gastrointestinal (GI) physiology. Crucially, although the market of ingestible devices is burgeoning, none of the existing products has the features needed for probing the link between GI dys\u002Ffunctions an",{"id":665,"funder":7,"programme":8,"title":666,"piName":10,"institution":667,"country":50,"year":13,"amount":14,"abstract":668},"cordis-european-research-council-award-101158035","High Performance and Large-Scale Electrodes for Selective Ion Recovery","WAGENINGEN UNIVERSITY","The growing global concern surrounding water scarcity spurs societal impact by ensuring accessible and affordable freshwater resources. Furthermore, the increasing demand for high-value, non-renewable resources like phosphate and lithium, often found in waster or process water streams, coupled with their dwindling availability, requires robust strategies to establish secure supply chains.Electrochemical deionization (ECD) stands out as a promising solution due to its ability to fine-tune selecti",{"id":670,"funder":7,"programme":8,"title":671,"piName":10,"institution":672,"country":38,"year":13,"amount":14,"abstract":673},"cordis-european-research-council-award-101158327","Method for Integrated All-Optical Biological Analysis at Scale","SORBONNE UNIVERSITE","The advent of light-emitting sensors and light-driven actuators has profoundly transformed the fields of biology and medical science over the past three decades.  These innovations enable the manipulation and monitoring of various physiological processes using light with remarkable precision in both time and space. Applications include the study of signaling and cell trafficking in healthy and malignant tissues, the unraveling of causal relationships within neural networks or the assessing the e",{"id":675,"funder":7,"programme":8,"title":676,"piName":10,"institution":385,"country":126,"year":13,"amount":14,"abstract":677},"cordis-european-research-council-award-101123280","Targeting eicosanoid metabolism to overcome tumor immunosuppression","The field of cancer immunotherapy has witnessed exciting therapeutic advances in the last decade, but still a large fraction of patients is not responsive and several cancer types are refractory to this therapy. The presence of a strongly immunosuppressive environment is a likely explanation for the suboptimal efficacy of immunotherapy. One of the most abundant and immune suppressive population in the tumor microenvironment (TME) is represented by tumor-associated macrophages (TAMs). Therefore, ",{"id":679,"funder":7,"programme":8,"title":680,"piName":10,"institution":681,"country":38,"year":13,"amount":14,"abstract":682},"cordis-european-research-council-award-101158350","Evasion-aware Detection Sandbox","EURECOM GIE","Mobile malware is getting harder and harder to detect. This is one of the reasons why malicious apps regularly appear on the official Play Store, despite the considerable effort Google and the security industry put into early detection and validation of each application. To mitigate this problem, EVADES aims to combine a number of novel techniques developed as part of the ERC BitCrumbs project into the first evasion-resilient, scalable, and maintainable sandbox to analyze Android applications. O",{"id":684,"funder":7,"programme":8,"title":685,"piName":10,"institution":686,"country":38,"year":13,"amount":14,"abstract":687},"cordis-european-research-council-award-101123291","Extreme Citizen Science Techniques And Tools In the Cloud","MUSEUM NATIONAL D'HISTOIRE NATURELLE","Over the past decade, the Extreme Citizen Science group has developed a methodology to engage low literate participants in the co-production of scientific knowledge, in an inclusive and ethical methodology that ensures community involvement and shared benefits. The methodology involved a set of technical tools, that are named Sapelli Collector, Sapelli Viewer, Sapelli Designer, and GeoKey. Prototypes of these tools were developed through the ERC-AdG-2015 ECSAnVis project and have been shown to b",{"id":689,"funder":7,"programme":8,"title":690,"piName":10,"institution":691,"country":692,"year":13,"amount":14,"abstract":693},"cordis-european-research-council-award-101158362","Elastocaloric COoling and HEAT-pumping","UNIVERZA V LJUBLJANI","SI","Decarbonization of the heating and cooling sector with renewables is a crucial step for the EU to achieve its energy and climate goals. Although heat pumps are considered renewable technology, they are all (as well as cooling and air-conditioning devices) based on relatively inefficient vapor-compression technology that still uses environmentally harmful refrigerants. The Kigali Amendment mandates phasing out high-global warming potential refrigerants, such as hydrofluorocarbons, in the EU by 20",{"id":695,"funder":7,"programme":8,"title":696,"piName":10,"institution":697,"country":156,"year":13,"amount":14,"abstract":698},"cordis-european-research-council-award-101157661","Tree-level biomass maps for Africa","KOBENHAVNS UNIVERSITET","Trees outside forests make up more than one quarter of the tree cover in Africa, but there is currently a lack of efficient and reliable monitoring systems for trees outside forests. Previous research suggests that most forest and landscape restoration (FLR) is occurring outside of contiguous forests, particularly in agroforestry systems. This implies that tree on fields, in particular those of smallholder farmers, as well as trees in restoration and plantation areas cannot be effectively and ra",{"id":700,"funder":7,"programme":8,"title":701,"piName":10,"institution":657,"country":20,"year":13,"amount":14,"abstract":702},"cordis-european-research-council-award-101158226","Non-invasive detection of interictal epileptiform discharges (IEDs) in the mesial temporal lobe (MTL) during sleep","Interictal epileptic discharges (IEDs) are pathological brain activities involving sharp spikes in electrical field potentials that occur preferentially during sleep. In epilepsy, IEDs occur between seizures, and often in deep brain regions such as the medial temporal lobe (MTL).IEDs during sleep disrupt memory and are associated with cognitive impairments. Importantly, MTL IEDs occur not only in epilepsy but also in multiple neuropsychiatric conditions including Alzheimers Disease (AD), Autism,",{"id":704,"funder":7,"programme":8,"title":705,"piName":10,"institution":281,"country":38,"year":13,"amount":14,"abstract":706},"cordis-european-research-council-award-101123233","Tree-based Ridge Extractor for image analysis","Accurate and reliable analyses of medical images have become a key step to determine the presence or severity of diseases, directly impacting the clinical care for patients. Among the numerous and various biomedical image analysis, the identification of blood vessels and the associated vascular trees is one of the most central topics for diagnosis of the coronary, lungs, liver, or retina, which require detection methods to assist physicians. Many such methods show intrinsic limitations due to th",{"id":708,"funder":7,"programme":8,"title":709,"piName":10,"institution":710,"country":238,"year":13,"amount":14,"abstract":711},"cordis-european-research-council-award-101158155","Micro-Scale Photonic Trace Gas Sensor","UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET","The demand for highly sensitive trace gas detection down to part-per-billion (ppb) levels and exceptional selectivity is paramount across various fields, including environmental monitoring, industrial process control, and healthcare. Currently, such capabilities are only accessible through bulky and expensive high-end sensors, limiting their use primarily to research settings. However, the ERC Starting Grant project sCENT has recently achieved a significant breakthrough by demonstrating the firs",{"id":713,"funder":7,"programme":8,"title":714,"piName":10,"institution":715,"country":426,"year":13,"amount":14,"abstract":716},"cordis-european-research-council-award-101158248","Unraveling Parkinson´s disease diagnostic","NOVA ID FCT - ASSOCIACAO PARA A INOVACAO E DESENVOLVIMENTO DA FCT","Parkinson´s disease (PD) is a progressive, chronic, and debilitating neurodegenerative disease for which there is no cure and no diagnostic test available. About 10 million people live with PD worldwide (1.2 million in Europe), and this number is expected to double by 2030 due to the aging population. PD has a high social and economic burden, and  there is the need to improve PD timely detection and diagnosis, especially in young people.UNMASK aims to validate the technological and business feas",{"id":718,"funder":7,"programme":8,"title":719,"piName":10,"institution":657,"country":20,"year":13,"amount":14,"abstract":720},"cordis-european-research-council-award-101158398","Diagnostics for cancer and cardiovascular diseases based on diet-derived sugars","Diet can dramatically affect health, and different dietary habits have been associated with various human diseases such as cancer, cardiovascular diseases (CVD), type II diabetes, obesity, and hypertension. In particular, high consumption of red meat has been frequently suggested as a risk factor for human cancers and CVD. We aim to develop biomarkers for cancer and CVD based on signatures of antibodies against glycans. We developed unique nano-printed arrays with various glycans. These will be ",{"id":722,"funder":7,"programme":8,"title":723,"piName":10,"institution":352,"country":50,"year":13,"amount":14,"abstract":724},"cordis-european-research-council-award-101158101","Mix and Match: One-step activation for targeted drug delivery","Current clinically approved drug delivery systems, such as liposome, PEGylated liposome, and polymeric micelle, predominantly rely on passive accumulation within tumor tissues by diffusion through the defective tumor vessels during circulation. The targeting efficacy toward cancer cells is very limited due to their inadequate interaction with cancer cells. The attachment of targeting ligands to nanocarriers has demonstrated its effectiveness in enhancing binding affinity and, consequently, facil",{"id":726,"funder":7,"programme":8,"title":727,"piName":10,"institution":125,"country":126,"year":13,"amount":14,"abstract":728},"cordis-european-research-council-award-101138304","Distributed wireless EEG sensor patches for auditory attention decoding in hearing technology","Over 400 million people worldwide suffer from disabling hearing loss. While the majority can be helped with a hearing aid, users still experience major difficulties in situations where multiple people talk simultaneously, leading to social isolation. Although algorithms exist to extract a single speaker from such a speech mixture, the current bottleneck is that a hearing aid does not know which of these speakers the user aims to attend.Recent research has shown that this auditory attention can b",{"id":730,"funder":7,"programme":8,"title":731,"piName":10,"institution":732,"country":26,"year":13,"amount":14,"abstract":733},"cordis-european-research-council-award-101158338","Generation, validation and use of a synthetic reporter of CAR T cell products function and dysfunction","MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)","Cell-based immunotherapy, particularly adoptive cell transfer (ACT) using engineered T cells, holds great promise as a therapeutic strategy for cancer treatment. However, challenges such as the manufacturing process, excessive antigen exposure, and the hostile tumor microenvironment often lead to dysfunctional T cell products, limiting their effectiveness in treating both blood cancers and solid tumors. We propose a novel tool to define in vitro conditions to enhance T cell product fitness throu",{"id":735,"funder":7,"programme":8,"title":736,"piName":10,"institution":281,"country":38,"year":13,"amount":14,"abstract":737},"cordis-european-research-council-award-101158062","MUlti-spectral Scattering matrix for Enhanced skin imaging","During the ERC REMINISCENCE project, we developed a new microscope whose performances exceed our initial expectations. Based on a reflection matrix approach of wave imaging, this device called DeepInsight provides an unprecedented imaging performance. It allows non-invasive, label-free, real-time and three-dimensional imaging of tissues with a 1 mm-penetration depth at a 500 nm-resolution. Beyond the structural information provided by standard reflectivity images, it also enables quantitative im",{"id":739,"funder":7,"programme":8,"title":740,"piName":10,"institution":741,"country":12,"year":13,"amount":14,"abstract":742},"cordis-european-research-council-award-101158245","Targeting the Imidazoline I1 receptor as a novel treatment for Atherosclerosis","CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)","Atherosclerosis (AT) is one of the main causes of death worldwide. Current treatments (e.g. lipid-lowering therapies) are still insufficient to tackle future CV events and we urgently need new complementary treatments to improve therapeutic efficacy. ImnovAth aims to develop the new idea of targeting a metabolite\u002Fmetabolite receptor axis to complete our preclinical results with an existing pharmacological agent that blocks this pathway, with the long-term goal of moving towards clinical trials a",{"id":744,"funder":7,"programme":8,"title":745,"piName":10,"institution":586,"country":26,"year":13,"amount":14,"abstract":746},"cordis-european-research-council-award-101158216","Inhibitors of ECF transporters as novel antibacterial agents","Antimicrobial resistance is a global health threat, urgently calling for the development of novel anti-infective strategies. We will adopt a multidisciplinary approach to design, synthesize and optimize derivatives targeting ECF transporters as antibacterial agents. The ECF transporters are transmembrane proteins involved in the uptake of vitamins predominantly in Gram-positive pathogens (e.g., Streptococcus pneumoniae, Enterococcus faecalis, E. faecium, Staphylococcus aureus). Their inhibition ",{"id":748,"funder":7,"programme":8,"title":749,"piName":10,"institution":491,"country":110,"year":13,"amount":14,"abstract":750},"cordis-european-research-council-award-101123123","Real-time, High-throughput, Coherent X-ray Microscopy: from Large-Scale Installations to Tabletop Device","Recent advances in Coherent X-ray Microscopy opened new exciting avenues for 2D\u002F3D imaging, allowing to visualize deformations in batteries and solar cells during charge migration, magnetic topologies, catalysts pollution, transistors fabrication defects, neuron activity. These emerging applications are expected to offer significant growth opportunities to market players in the coming years, complementing the possibilities offered by optical and electron-based microscopy methods. However, the ex",{"id":752,"funder":7,"programme":8,"title":753,"piName":10,"institution":754,"country":12,"year":13,"amount":14,"abstract":755},"cordis-european-research-council-award-101138041","A light-efficient microscope for fast volumetric imaging of photon starved samples","FUNDACIO INSTITUT DE CIENCIES FOTONIQUES","Bioluminescence microscopy offers a powerful tool for background free imaging of biological samples without an excitation laser. This enabling technology would afford a wide range of applications in the life sciences, where fluorescence microscopy is prohibitive.Currently, commercial solutions for bioluminescence imaging suffer from low spatiotemporal resolution, due to photon-starved samples. LowLiteScope aims to overcome these limitations by radically redesigning the optical path, data acquisi",{"id":757,"funder":7,"programme":8,"title":758,"piName":10,"institution":662,"country":110,"year":13,"amount":14,"abstract":759},"cordis-european-research-council-award-101138734","Against prostheses abandonment: immersive and low-cost platform for the rehabilitation of upper-limb amputees","Up to 44% is the abandonment rate of upper-limb prostheses. The lack of training and rehabilitation is among the reasons underlying the high rejection rate. When available, traditional treatments lead to ineffective results because they are repetitive, tedious, and discouraging. When considering the EU investments in prosthetic development (173.5 million, period 2019-2022) and the costs granted by the national health system for assistance, this problem gets worse. BRAINmade proposes a paradigm s",{"id":761,"funder":7,"programme":8,"title":762,"piName":10,"institution":763,"country":126,"year":13,"amount":14,"abstract":764},"cordis-european-research-council-award-101123406","Innovative Digital Twins for Advanced Combustion Technologies","UNIVERSITE LIBRE DE BRUXELLES","Significant adoption of renewable sources will be witnessed in future years to meet the long-term objective of CO2 neutrality and mitigate the effects of global warming. While electrification will play a key role in the transition to a sustainable energy system, combustion processes will remain part of the picture, requiring sustainable combustion technologies and renewable synthetic fuels. The design and development of novel combustion technologies in power and heat generation, transportation a",{"id":766,"funder":7,"programme":8,"title":767,"piName":10,"institution":768,"country":197,"year":13,"amount":14,"abstract":769},"cordis-european-research-council-award-101157752","Mycelium-based substrate for sustainable flexible PCBs","UNIVERSITAT LINZ","Printed circuit boards are an indispensable technology present in all classes of modern electronics. Their flexible embodiments (flexPCBs) enable current and emerging form factors and drive the transition to human-centered applications. At the same time, PCBs are notoriously difficult to recycle and contribute majorly to the growth of electronic waste and an unsustainable use of resources. A paradigm change towards bioderived and biodegradable materials promises a remedy, however so far, no viab",{"id":771,"funder":7,"programme":8,"title":772,"piName":10,"institution":773,"country":50,"year":13,"amount":14,"abstract":774},"cordis-european-research-council-award-101138326","The Delft Laminar Hump: A novel local surface geometry for passive laminarization of aircraft wings","TECHNISCHE UNIVERSITEIT DELFT","The exponential growth in aviation calls for radical new technologies to curb aircraft fuel consumption and emissions. At the heart of the problem, lies aerodynamic drag. Laminarization, namely the extension of laminar flow over the wing, holds immense potential for reducing aerodynamic drag by up to 15%. Unfortunately, many solutions proposed so far are costly, complex, and unreliable, thus obstructing laminarization from reaching industrial-scale application.The Delft Laminar Hump aims at brea",{"id":776,"funder":7,"programme":8,"title":777,"piName":10,"institution":778,"country":779,"year":13,"amount":14,"abstract":780},"cordis-european-research-council-award-101157994","Preclinical in vivo proof-of-concept for cyclic oligopeptide rescuers of pathogenic protein misfolding and aggregation associated with neurodegeneration","RESQ BIOTECH IDIOTIKI KEFALAIOUCHIKI ETAIREIA","EL","Within the ERC Consolidator Grant ProMiDis, my team and I have developed genetically engineered bacteria that function as a stand-alone, living discovery platform for short, drug-like cyclic peptides rescuing the misfolding and aggregation of proteins associated with human diseases (protein misfolding diseases, PMDs). By applying this technology, we have discovered hundreds of new molecules-putative drugs against notorious PMDs, such as Alzheimer’s disease and amyotrophic lateral sclerosis (ALS)",{"id":782,"funder":7,"programme":8,"title":783,"piName":10,"institution":784,"country":26,"year":13,"amount":14,"abstract":785},"cordis-european-research-council-award-101157775","Liquid Dosimetry via Electron Paramagnetic Resonance Spectroscopy","UNIVERSITAT KONSTANZ","The problem: Lack of water-equivalent dosimeters for radiotherapyCancer is a global public health problem. Radiotherapy is generally used as an essential method of cancer treatment. Measuring the absorbed dose of radiation to ensure that the radiation delivered to the patient is accurate, is paramount and critical to patient safety, since tumor control and side-effects are highly sensitive to the applied dose. For this purpose, in-vivo dosimetry (IVD) can be performed as a patient-specific measu",{"id":787,"funder":7,"programme":8,"title":788,"piName":10,"institution":789,"country":44,"year":13,"amount":14,"abstract":790},"cordis-european-research-council-award-101138356","Spatial transcriptomics chips with sequencing-based microscopy","KUNGLIGA TEKNISKA HOEGSKOLAN","We propose a technology platform for low cost, high resolution spatial transcriptomics surfaces.  Spatial transcriptomics is a high cost research methodology for resolving the spatial variation of genes in a tissue by capturing mRNA transcripts on a surface containing molecular address markers. To produce these surfaces, current methods rely on either printing technology with explicit assignment of unique address ID's to spatial locations or else random scattering of molecular ID's that are then",{"id":792,"funder":7,"programme":8,"title":793,"piName":10,"institution":794,"country":44,"year":13,"amount":14,"abstract":795},"cordis-european-research-council-award-101158051","Long-range and high-data-rate wireless communication using chirp spread spectrum modulated spintronic oscillators.","GOETEBORGS UNIVERSITET","Wireless communication is an indispensable facet of modern society, offering remarkable performance and societal benefits. It promotes vast network coverage, scalability, and the ability to connect multiple devices simultaneously and in easily reconfigurable ways. These advantages have facilitated the growth of many sectors, including the Internet of Things (IoT), wireless sensor networks, telemedicine, and mobile commerce.  The wireless communication market is valued at approximately 930B globa",{"id":797,"funder":7,"programme":8,"title":798,"piName":10,"institution":799,"country":110,"year":13,"amount":14,"abstract":800},"cordis-european-research-council-award-101157420","Microgel-nanoparticles colorimetric sensor for pesticide detection","CONSIGLIO NAZIONALE DELLE RICERCHE","The MICROSENS POC proposal aims to realize a novel naked-eye assay to detect Paraquat (PQ), a harmful pesticide, that has been banned in Europe since 2007, but is still employed in many countries, endangering health and the environment globally. PQ is present at very low concentrations and, hence, there is an urgent need for sensors with high detection capability. To this end, building on the knowledge gained during the PIs recent ERC grant, we will exploit the thermoresponsivity of microgels co",{"id":802,"funder":7,"programme":8,"title":803,"piName":10,"institution":773,"country":50,"year":13,"amount":14,"abstract":804},"cordis-european-research-council-award-101158219","High throughput development platform for oligonucleotide aptamers","The binding kinetics of an affinity probethe speed and duration with which it attaches to a target moleculemust be precisely tuned for numerous applications in therapeutics, super-resolution microscopy, and biochemical assays. The current methods of development lack the capability to specify these binding kinetics during probe design, resulting in the potential for effective drugs and relevant biological properties to remain undiscovered. Here, I introduce a game-changing solution: Single-molecu",{"id":806,"funder":7,"programme":8,"title":807,"piName":10,"institution":808,"country":26,"year":13,"amount":14,"abstract":809},"cordis-european-research-council-award-101150675","High-throughput production of anisotropic 3D human tissue models","DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV","The limitations of current in vitro tissue models pose a significant challenge in drug discovery and personalized medicine, leading to inefficiencies and unreliability in preclinical testing. These shortcomings result in high costs and prolonged timelines for drug development, straining resources and delaying patient access to innovative treatments. This is mainly due to the currently available cell and tissue models based on flat petri dishes and isotropic hydrogels, which fail to accurately re",{"id":811,"funder":7,"programme":8,"title":812,"piName":10,"institution":19,"country":20,"year":13,"amount":14,"abstract":813},"cordis-european-research-council-award-101158206","Listening to Silence: The First Blood Test for Risk of Individuals at Prophylactic Time Windows to Develop Type 2 Diabetes Mellitus","Type 2 Diabetes Mellitus (T2DM) is a heterogeneous disease, associated with mortality and severe morbidity, and affecting hundreds of millions of people around the globe. Despite some misconception accepted in the public, current models to predict the onset of T2DM have insufficient power, and are generally limited to individuals that already progressed into pre-diabetes states, at which the assignment of disease-preventing treatments is largely ineffective. Clinical-level prediction power (AUC>",{"id":815,"funder":7,"programme":8,"title":816,"piName":10,"institution":342,"country":38,"year":13,"amount":14,"abstract":817},"cordis-european-research-council-award-101138291","Skill Performance Estimation from cARdiac Signals","In any learning situation, be it math education, language learning or sport training, different learners have different abilities, motivations and capacities at any given time. Thus, an optimal learning can only be achieved with personalized training solutions, dynamically adapted to each learner’s cognitive and\u002For physical states. The scientific literature showed that such states could be estimated from Cardiac Signals (CS). In ERC PoC SPEARS, we thus propose to redefine consumer training apps,",{"id":819,"funder":7,"programme":8,"title":820,"piName":10,"institution":25,"country":26,"year":13,"amount":14,"abstract":821},"cordis-european-research-council-award-101138779","An integral solution for quantifying intracellular lipid transport using close to native lipid probes.","Dysregulation of lipid transport and metabolism is at the center of many diseases. Despite its crucial role, gaining a full understanding of lipid transport remains challenging as visualizing lipids and their transport by microscopy is almost impossible. By providing technological solutions to this problem, we envision to enable new therapeutic strategies with the corresponding benefits for society at large. A better understanding of lipid transport can help guide the design of drugs to for exam",{"id":823,"funder":7,"programme":8,"title":824,"piName":10,"institution":115,"country":50,"year":13,"amount":14,"abstract":825},"cordis-european-research-council-award-101138903","Targeting the dark side of the human genome—non-coding regulatory elements—to treat diseases","The 98% of the human genome, sometimes referred to as the dark side of the human genome, contains many non-coding regulatory elements (NCREs), which control the combinational expression of the limited number of genes (only 2% of the genome) to form diverse cell types and tissues of a complex human body, all from the identical copy of the genome. Most genetic variants and mutations also lie in NCREs. However, the number of NCREs as potential therapeutic targets remains very limited. In TargetNCRE",{"id":827,"funder":7,"programme":8,"title":828,"piName":10,"institution":366,"country":110,"year":13,"amount":14,"abstract":829},"cordis-european-research-council-award-101146025","Biomimetic Sensorized Barriers-on-a-Chip: Unveiling a new Generation of Market-Ready Investigation Tools","The lack of reliable in vitro pre-clinical models represents a critical aspect unanimously recognized by the scientific community as detrimental in the pathway of bringing new medications from the laboratory to the bedside: addressing this issue would provide immense benefits to drug discovery and development processes, by ethically limiting animal testing and drastically reducing costly failures in clinical trials. To date, most in vitro models fail at recapitulating the physiological microenvi",{"id":831,"funder":7,"programme":8,"title":832,"piName":10,"institution":223,"country":20,"year":13,"amount":14,"abstract":833},"cordis-european-research-council-award-101158064","An Insulin-Gold Nanoplatform as Enhanced Antibody-Drug Conjugate Cancer Therapy","Antibody-drug conjugates (ADCs) have emerged as promising therapies by combining the precision targeting abilities of antibodies with the potency of chemotherapy drugs, to directly attack cancer cells and minimize damage to healthy tissue. However, approved ADCs show low efficacies in treating solid tumours, due to inherent challenges. These include design challenges, which limit the drug-antibody ratio and the ability to integrate multiple drug types, and delivery challenges, in which pharmacok",{"id":835,"funder":7,"programme":8,"title":836,"piName":10,"institution":837,"country":26,"year":13,"amount":14,"abstract":838},"cordis-european-research-council-award-101155832","Practical, Learning-Based Tools for Finding and Fixing Bugs","UNIVERSITY OF STUTTGART","Software bugs are a major problem for software developers and users alike, as they cause crashes, security vulnerabilities, and data loss. Unfortunately, identifying and fixing software bugs is among the most expensive and time-consuming tasks in software development, accounting for 28% to 50% of the costs of a billion-dollar industry. The LearnBugs ERC project, on which this proposal is based, has developed ground-breaking techniques to automatically find bugs and to propose suitable bug fixes.",{"id":840,"funder":7,"programme":8,"title":841,"piName":10,"institution":842,"country":12,"year":13,"amount":14,"abstract":843},"cordis-european-research-council-award-101158023","Energy-Efficient Highly Accurate Data Prefetching","UNIVERSIDAD DE MURCIA","Data prefetchers are ubiquitous in current high-performance computers such as those manufactured by Intel, ARM, AMD, or IBM, as they play a fundamental role in hiding long-latency memory accesses. Prefetchers predict the data that will be needed by a processor in the future and fetch such data ahead of execution. State-of-the-art data prefetchers, push the limits of performance but often without caring about energy efficiency. The energy efficiency of a prefetcher is dictated by its accuracy, wh",{"id":845,"funder":7,"programme":8,"title":846,"piName":10,"institution":847,"country":156,"year":13,"amount":14,"abstract":848},"cordis-european-research-council-award-101138983","Clocking the conduction velocity of the visual pathway with optically pumped magnetometers","AARHUS UNIVERSITET","The human visual pathway carries high volumes of information from the retina to distant regions of visual cortex. The speed of this information transfer, retinocortical conduction time, has been proposed as a diagnostic measure of neurodegeneration. This conduction time has typically been estimated based on relatively slow evoked responses, although we now know that high-frequency activity in both the retina and visual cortex precede slower evoked responses by several tens of milliseconds. In ad",{"id":850,"funder":7,"programme":8,"title":851,"piName":10,"institution":170,"country":50,"year":13,"amount":14,"abstract":852},"cordis-european-research-council-award-101155770","TOMAC: Bioinspired  Flow Generation in Tubeless Organ-on-a-chip using Magnetic Artificial Cilia","Currently, 90% of the drugs fail to pass clinical trials1. One of the key reasons is that the animal models used in the preclinical phase poorly predict the human response to the drugs. Organ-on-a-Chip (OoC) is a game changing technology as one of the alternative methodolgies to animal models. The heart of an OoC system is an ‘Organ-chip’: cm-sized devices with micro-channels and -chambers in which human cells can be grown to closely mimic human tissues. More and more evidence shows that OoCs ar",{"id":854,"funder":7,"programme":8,"title":855,"piName":10,"institution":856,"country":12,"year":13,"amount":14,"abstract":857},"cordis-european-research-council-award-101158166","Development of rationally designed enzyme kits","UNIVERSITAT DE GIRONA","Enzymes exhibit high efficiency, specificity, selectivity, biodegradability, non-toxicity, and the ability to function effectively under gentle biological conditions. These qualities render enzymes a sustainable and eco-friendly substitute for traditional catalysts within industrial settings. However, harnessing enzymes for industrial applications often necessitates extensive and costly experimental engineering efforts. Computational methods hold promise as potential solutions, but these have no",{"id":859,"funder":7,"programme":8,"title":860,"piName":10,"institution":412,"country":12,"year":13,"amount":14,"abstract":861},"cordis-european-research-council-award-101157423","Nanowire device for single virus delivery and sensing in vacuum","Airborne viruses causing respiratory diseases represent a mayor global health threat, being viruses with RNA-genomes from animal reservoirs highly likely to cause further public health emergencies in the future. VIR-Quantify aims to provide proof of concept for a technology capable of highly sensitive, fast and untargeted airborne virus detection with infectivity assessment, providing a comparative advantage in the competitive landscape. VIR-Quantify builds upon an unprecedented application of N",{"id":863,"funder":7,"programme":8,"title":864,"piName":10,"institution":65,"country":20,"year":13,"amount":14,"abstract":865},"cordis-european-research-council-award-101189449","Bioactive reinforcing bioink for hybrid bioprinting of implantable bone","3D bioprinting is an emerging technique that offers promise for fabricating implantable tissues. Despite significant advancements, the field struggles to replicate the mechanical robustness and biological complexity of native tissues, particularly in applications requiring high mechanical strength such as bone. This proposal introduces 'BioForceInk,' a bioactive reinforcing bioink designed for direct bioprinting alongside a cell-laden hydrogel within a cell-conductive environment. The microparti",{"id":867,"funder":7,"programme":8,"title":868,"piName":10,"institution":869,"country":870,"year":13,"amount":14,"abstract":871},"cordis-european-research-council-award-101189448","WEARABLE ULTRASOUND FOR CONTINUOUS BLADDER MONITORING","KOC UNIVERSITY","TR","Millions of people worldwide suffer from lower urinary tract dysfunction (LUTD), which costs billions of dollars in medical expenses due to a lack of reliable continuous monitoring options. A vital measure of the course of LUTD is bladder volume, but measuring it accurately is difficult because of anatomical constraints in the pelvic region and body. The monitoring techniques used today employ tethered solutions and personnel with training. BladderWatch offers a wireless, compact, and conformal ",{"id":873,"funder":7,"programme":8,"title":874,"piName":10,"institution":508,"country":197,"year":13,"amount":14,"abstract":875},"cordis-european-research-council-award-101138423","60-Hz light entrainment to unlock mental health conditions","Mental health problems are a critical and ever-increasing burden to society. Psychiatric medications aim to adjust imbalances in synapse signaling, but often have only moderate-to-weak efficacy. Psychiatric medications aim to adjust imbalance in synapse signaling but often have only moderate-to-weak efficacy. The main challenge is that certain neuronal infrastructures for cognitive and emotional skills are secured with a rigid extracellular matrix known as the perineuronal net (PNN) that forms a",{"id":877,"funder":7,"programme":8,"title":878,"piName":10,"institution":125,"country":126,"year":13,"amount":14,"abstract":879},"cordis-european-research-council-award-101158376","Prediction + Optimisation for scheduling and rostering with CMPpy","In today’s world, organizations across various industries face the challenge of efficiently scheduling their production processes and rostering their workforce optimally. However, despite consistent improvements in combinatorial optimization software for scheduling and rostering, the complexity of this task continues to grow due to uncertainty about multiple factors such as employee availability, demand fluctuations, supplier variability, variable prices, the impact of weather and the increasing",{"id":881,"funder":7,"programme":8,"title":882,"piName":10,"institution":883,"country":12,"year":13,"amount":14,"abstract":884},"cordis-european-research-council-award-101123000","Developing Bias Auditing and Mitigation Tools for Self-Assessment of AI Conformity with the EU AI Act through Statistical Matching","BCAM - BASQUE CENTER FOR APPLIED MATHEMATICS","The vision behind Act.AI is to utilize statistical matching for mitigating and auditing bias in Artificial Intelligence (AI) models. AI has been rapidly growing in various industries, from financial services to healthcare, education, and job recruitment. However, as AI algorithms have become increasingly sophisticated and pervasive in decision-making processes, concerns have arisen about their fairness and compliance with regulations. In particular, the EU AI Act requires that AI providers in hi",{"id":886,"funder":7,"programme":8,"title":887,"piName":10,"institution":43,"country":44,"year":13,"amount":14,"abstract":888},"cordis-european-research-council-award-101137861","Sensor islet organoids (SILORGS) for in vivo identification of anti-diabetic drugs","To develop new drugs for treatment of diabetes, there is an immediate need for an in vivo approach allowing the assessment of β-cell function and survival in the living organism non-invasively, longitudinally and at single-cell resolution. We therefore transplant genetically engineered sensor islet organoids into the anterior chamber of the eye of mice for functional microscopic imaging. Using the cornea as a natural body-window, following their engraftment various aspects of β-cell function and",{"id":890,"funder":7,"programme":8,"title":891,"piName":10,"institution":125,"country":126,"year":13,"amount":14,"abstract":892},"cordis-european-research-council-award-101189364","Towards modulator therapy for ADA2 deficiency","Human ADA2 deficiency is a rare inborn error of immunity caused by pathogenic variants in ADA2. The disease has a wide array of presentations ranging from vasculitis of the skin to the central nervous system (with strokes), fevers and immunodeficiency to cytopenia and bone marrow failure. Mortality is 10%, and occurs mostly in childhood. TNF inhibitor treatment is efficient for treating the vasculitis, but the bone marrow failure is refractory to treatment and requires hematopoietic stem cell tr",{"id":894,"funder":7,"programme":8,"title":895,"piName":10,"institution":252,"country":12,"year":13,"amount":14,"abstract":896},"cordis-european-research-council-award-101113301","Universal 3D printer bioink for Type 1 diabetes cell therapy","Type 1 Diabetes (T1DM) results from autoimmune destruction of pancreatic insulin-producing -cells. Nowadays, insulin injections remain the leading therapeutic option. However, injection treatment fails to emulate the highly dynamic insulin release that -cells provide. During the last years, 3D cell-laden microspheres have been proposed as a major platform for bioengineering insulin-secreting constructs for tissue graft implantation and a model for in vitro drug screening platforms. Current micro",{"id":898,"funder":7,"programme":8,"title":899,"piName":10,"institution":900,"country":426,"year":13,"amount":14,"abstract":901},"cordis-european-research-council-award-101155808","High performance hydrophobic suberin nanoparticles for the generation of liquid-air biphasic droplets with application in food and therapeutics","UNIVERSIDADE NOVA DE LISBOA","An antibubble is a droplet of liquid with a shell surrounded by a thin film of gas. Antibubbles have many potential applications, e.g. drug delivery with application in a clinical setting and the food industry. The major challenge is to develop antibubbles with a long life time; essential for industry usage. The gas shell can be stabilized using hydrophobic nanoparticles to create a particle shell surrounding the air. The use of particles, instead of surfactants, to stabilize dispersed systems i",{"id":903,"funder":7,"programme":8,"title":904,"piName":10,"institution":900,"country":426,"year":13,"amount":14,"abstract":905},"cordis-european-research-council-award-101157564","Novel Fiber Cotton Coloration for a Revolutionary Sustainability Breakthrough in Textile Applications","Cotton is the world's most important non-food crop, accounting for 35% of global fiber production, but it is environmentally demanding and resource-intensive. Its production, especially the dyeing process, pollutes and depletes water and soil resources. The current strategies for cotton dyeing still rely on old manufacturing processes that yield large quantities of chemical and water waste. Thus, it is urgent to seek sustainable alternatives to meet acceptable environmental and social standards.",{"id":907,"funder":7,"programme":8,"title":908,"piName":10,"institution":366,"country":110,"year":13,"amount":14,"abstract":909},"cordis-european-research-council-award-101187935","Lattice Boltzmann For Advanced SimulaTions","The intricate dynamics of fluid interfaces, disordered liquid-liquid emulsions, and soft microfluidic droplet crystals, collectively knownas soft glass materials (SGM), pose challenges to non-equilibrium thermodynamics and hold profound implications for engineeringapplications such as combustion, materials design, and food processing. Advances in SGM modeling within the ERC COPMAT projectoffer opportunities for innovative mesoscale materials in fields like tissue engineering, photonics, and cata",{"id":911,"funder":7,"programme":8,"title":912,"piName":10,"institution":155,"country":156,"year":13,"amount":14,"abstract":913},"cordis-european-research-council-award-101189436","Modern Equation of State for Electrolytes","The objective of this project is to develop and make available in various forms an equation of state for electrolyte solutions, eSAFT-VR Mie, developed during the ERC project New Paradigm in Electrolyte Thermodynamics. The model can be applied across a wide range of temperatures, pressures, and solvents, solving the problems of currently used models in industry and research. We aim to integrate the model into a user-friendly tool featuring a Guided User Interface (GUI) and a CAPE-OPEN or user mo",{"id":915,"funder":7,"programme":8,"title":916,"piName":10,"institution":120,"country":110,"year":13,"amount":14,"abstract":917},"cordis-european-research-council-award-101189358","Accelerated X-in-the-loop Environment for Small Satellite Testing","The New Space is expected to become the biggest industry in human history. In 2023, the global space economy was valued at about $500B. The number of space probes is bound to thrive, yet their growth is unsustainable: developing spacecraft autonomy is paramount to remove the costs and limits of human-in-the-loop operation activities. However, developing resilient autonomous technologies requires extensive empirical testing in representative environmental conditions, and access-to-space costs are",{"id":919,"funder":7,"programme":8,"title":920,"piName":10,"institution":31,"country":32,"year":13,"amount":14,"abstract":921},"cordis-european-research-council-award-101189530","Associative metal-free ElectROlytes for Battery Energy STorage","Battery energy storage systems (BESS) offer attractive alternatives to pumped hydroelectric and compressed air energy storage methods on account of their modularity, flexibility, and independence from geographical conditions. However, new BESS installations are primarily lithium-ion batteries alongside increasing market share for vanadium redox flow batteries, which both rely heavily on key metals with significant cost and safety implications as well as geopolitical concerns. The EU-funded AERO ",{"id":923,"funder":7,"programme":8,"title":924,"piName":10,"institution":366,"country":110,"year":13,"amount":14,"abstract":925},"cordis-european-research-council-award-101156586","Colloidal Indium Arsenide quantum dots as short-wave infrared single photon emitters","MOONSHOT aims at developing a novel single-photon emitting material that operates in the telecommunication wavelength range (1300-1600 nm, O- and C-bands) and is compliant with the “Restriction of Hazardous Substances in Electrical and Electronic Equipment” (RoHS). The main motivation for such objective is that single-photon sources based on epitaxial quantum dots (QDs) are now a mature technology available on the market that is outperforming laser cooled atoms or spontaneous parametric down con",{"id":927,"funder":7,"programme":8,"title":928,"piName":10,"institution":431,"country":20,"year":13,"amount":14,"abstract":929},"cordis-european-research-council-award-101188091","Engineering Eco-Friendly and Sustainable Reflecting Crystals in Yeast to Replace Hazardous TiO2 Based Pigments","The superior optical properties and stability of Titanium dioxide (TiO2) has made the material attractive to many industries, for use in food, cosmetics, and pharmaceuticals. Despite these benefits, the wide use of TiO2 has raised significant health concerns, culminating in the 2022 European Union's decision to ban its use as a food additive. This regulatory shift has precipitated an urgent demand for healthier, environmentally sustainable alternatives that do not compromise on performance. Unfo",{"id":931,"funder":7,"programme":8,"title":932,"piName":10,"institution":657,"country":20,"year":13,"amount":14,"abstract":933},"cordis-european-research-council-award-101123407","BioBone: Bioactive Hydrogel-based Implants to Induce Bone Regeneration","Osteosarcoma and Ewing sarcoma are the most common types of cancer in patients younger than 30 years. The gold standard treatment is bone tumor resection followed by reconstruction of the tissue, thereby allowing the salvage of the limb. Titanium and its alloys are mostly used in such orthopedic surgeries due to their biocompatibility and excellent mechanical properties. A novel, cutting-edge technology of patient-specific implants, 3-dimensional (3D) printed porous titanium implants, was recent",{"id":935,"funder":7,"programme":8,"title":936,"piName":10,"institution":937,"country":197,"year":13,"amount":14,"abstract":938},"cordis-european-research-council-award-101189441","Translating Tudor domain splicing inhibitors for oncological applications","CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH","In our effort to characterize metabolic activities in the cells nucleus, we discovered that the understudied Tudor domain protein SMNDC1 controls the repression of insulin in pancreatic alpha cells through its role as a splicing modulator. Based on this finding, we developed the first selective SMNDC1 Tudor domain inhibitors, for which we observe interesting preliminary data on insulin induction in primary human pancreatic islets. However, as a pan-essential gene expressed in most tissues, SMNDC",{"id":940,"funder":7,"programme":8,"title":941,"piName":10,"institution":789,"country":44,"year":13,"amount":14,"abstract":942},"cordis-european-research-council-award-101158292","A new technology to probe molecular interaction in cells at high throughput","Protein oligomers and aggregates are pillars of many cellular processes and can be associated with a number of life-threatening neurodegenerative diseases. These processes are often context-dependent but are hard to detect in situ with available technologies. The ideal instrument can target specific proteins of medical interest in their physiological contexts, resolve nano-distances (1-100 nm) and capture dynamics of association and dissociation (ns-ms).The DiffusOMICS project aims to fill this ",{"id":944,"funder":7,"programme":8,"title":945,"piName":10,"institution":611,"country":38,"year":13,"amount":14,"abstract":946},"cordis-european-research-council-award-101157728","Agonists of the microprotein BRAWNIN in the treatment of Charcot Marie Tooth disease","This project will provide proof of concept for the neuroprotective potential of agonists of the mitochondrial protein BRAWNIN. We have identified that BRAWNIN is an important regulator of mitochondrial function in neurons. Mitochondria are essential organelles to support metabolic homeostasis in the cell. Mounting evidence in the literature demonstrate that mitochondria and more broadly metabolic regulation is central to the function of the nervous system. Axons are especially affected by metabo",{"id":948,"funder":7,"programme":8,"title":949,"piName":10,"institution":65,"country":20,"year":13,"amount":14,"abstract":950},"cordis-european-research-council-award-101158055","Fast and simple biomarker detection by computational microscopy","Detection of low concentrations of biomarkers, such as low-abundant proteins in physiological samples, is crucial for early-stage diagnosis and disease monitoring. However, existing detection methods are often laborious, costly, and time consuming, rendering them unsuitable for such applications. Based on advances in computational PSF engineering microscopy made during our ERC Starting Grant, and in combination with microfluidic design, we developed a simple and fast biomarker detection method w",{"id":952,"funder":7,"programme":8,"title":953,"piName":10,"institution":954,"country":126,"year":13,"amount":14,"abstract":955},"cordis-european-research-council-award-101113322","Vortex microflow inducer that enables detection of ultra-low concentrations of species in sensors","VRIJE UNIVERSITEIT BRUSSEL","According to WHO, in 2018, more than 100,000 chemicals were released into the global environment due to their production, use, and disposal. In this regard, water is the key element for their effective transport in the food chain and since remediation can be extremely difficult, such pollution is leading to acute or chronic toxicity in aquatic organisms, loss of habitats and biodiversity as well as human diseases. But, industrial wastewater flows contain hazardous and toxic species that are not ",200,{"programme":8,"total":958,"withPiName":959,"firstYear":960,"lastYear":961,"countryCount":962,"perYear":963,"topInstitutions":1001,"topCountries":1069},2347,7,2014,2027,31,[964,966,969,971,973,976,979,982,985,988,991,993,996,999],{"year":960,"count":965},13,{"year":967,"count":968},2015,142,{"year":970,"count":968},2016,{"year":972,"count":956},2017,{"year":974,"count":975},2018,160,{"year":977,"count":978},2019,176,{"year":980,"count":981},2020,174,{"year":983,"count":984},2021,120,{"year":986,"count":987},2022,198,{"year":989,"count":990},2023,231,{"year":13,"count":992},237,{"year":994,"count":995},2025,265,{"year":997,"count":998},2026,264,{"year":961,"count":1000},25,[1002,1005,1008,1011,1014,1017,1020,1023,1026,1028,1030,1033,1036,1039,1041,1044,1047,1049,1052,1054,1056,1058,1061,1064,1066],{"name":1003,"count":1004},"Centre National de la Recherche Scientifique CNRS",84,{"name":1006,"count":1007},"Weizmann Institute of Science",65,{"name":1009,"count":1010},"Technion - Israel Institute of Technology",43,{"name":1012,"count":1013},"The Chancellor Masters and Scholars of the University of Cambridge",42,{"name":1015,"count":1016},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",41,{"name":1018,"count":1019},"Fondazione Istituto Italiano di Tecnologia",34,{"name":1021,"count":1022},"Tel Aviv University",33,{"name":1024,"count":1025},"Imperial College of Science Technology and Medicine",32,{"name":1027,"count":1025},"Politecnico di Milano",{"name":1029,"count":962},"Institut National de la Sante Et de la Recherche Medicale",{"name":1031,"count":1032},"Ecole Polytechnique Federale de Lausanne",30,{"name":1034,"count":1035},"Universiteit Twente",29,{"name":1037,"count":1038},"The Hebrew University of Jerusalem",28,{"name":1040,"count":1038},"Universiteit Gent",{"name":1042,"count":1043},"The Chancellor, Masters and Scholars of the University of Oxford",27,{"name":1045,"count":1046},"Danmarks Tekniske Universitet",24,{"name":1048,"count":1046},"Vib Vzw",{"name":1050,"count":1051},"Katholieke Universiteit Leuven",23,{"name":1053,"count":1051},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",{"name":1055,"count":1051},"Technische Universitaet Muenchen",{"name":1057,"count":1051},"Technische Universiteit Delft",{"name":1059,"count":1060},"The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undivided Trinity of Queen Elizabeth Near Dublin",22,{"name":1062,"count":1063},"Technische Universiteit Eindhoven",21,{"name":1065,"count":1063},"Universiteit Leiden",{"name":1067,"count":1068},"Eidgenoessische Technische Hochschule Zuerich",20,[1070,1072,1074,1076,1078,1080,1082,1084,1086,1089,1091,1093,1095,1097,1099,1101,1102,1104,1106,1108,1110,1113,1115,1116,1119],{"name":26,"count":1071},299,{"name":12,"count":1073},273,{"name":32,"count":1075},261,{"name":50,"count":1077},254,{"name":110,"count":1079},221,{"name":38,"count":1081},215,{"name":20,"count":1083},191,{"name":126,"count":1085},109,{"name":1087,"count":1088},"CH",85,{"name":44,"count":1090},72,{"name":197,"count":1092},62,{"name":156,"count":1094},50,{"name":191,"count":1096},48,{"name":207,"count":1098},47,{"name":426,"count":1100},40,{"name":779,"count":1068},{"name":870,"count":1103},19,{"name":238,"count":1105},17,{"name":94,"count":1107},12,{"name":213,"count":1109},11,{"name":1111,"count":1112},"LU",10,{"name":532,"count":1114},8,{"name":692,"count":1114},{"name":1117,"count":1118},"HU",5,{"name":1120,"count":1121},"HR",2]