[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-proof-of-concept-2025":3,"awarded-stats-erc-proof-of-concept":961},{"awarded":4,"total":960},[5,16,22,28,34,39,45,50,56,61,66,72,77,83,88,94,99,105,109,113,118,124,128,132,136,140,145,149,154,159,164,169,174,179,184,189,193,198,203,208,212,216,222,226,231,236,241,246,251,256,261,266,271,276,281,286,291,296,301,307,312,317,321,326,332,337,342,346,351,355,359,364,370,375,380,385,390,394,398,403,408,412,417,423,428,433,438,443,447,452,457,461,465,470,474,479,484,488,493,498,502,508,512,516,522,527,531,536,540,545,550,555,559,563,568,572,576,581,587,592,596,600,605,609,614,619,624,629,634,639,643,647,652,656,660,664,668,672,677,681,685,689,693,697,701,707,711,715,720,725,730,735,741,746,751,756,760,764,768,772,777,781,786,790,795,800,805,810,814,818,823,827,833,838,842,846,850,855,861,866,870,874,879,883,887,891,896,901,907,912,917,921,925,930,934,938,942,946,950,955],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-101228702","European Research Council","ERC Proof of Concept","GALVANI Scalable Workflow Innovation for Focal tES Therapy",null,"NEUROELECTRICS BARCELONA SL","ES",2025,"€150,000","The ERC Galvani project aims to revolutionize transcranial electrical brain stimulation (tES) therapy for epilepsy through acomputational breakthrough. By combining the expertise of clinical researchers and computational neuroscientists, the project willdevelop personalized brain stimulation solutions integrating magnetic resonance imaging (MRI) and stereoelectroencephalography(SEEG) data into advanced brain models. Neuroelectrics, a leader in medical neurotechnology, is implementing these solut",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":20,"year":13,"amount":14,"abstract":21},"cordis-european-research-council-award-101248075","Simultaneous Trace Gas Detection Platform","TECHNISCHE UNIVERSITAET GRAZ","AT","In response to the European Council's revision of air quality directives in October 2024, there is an urgent need to improve monitoring of global pollution gas concentrations and develop effective air quality management strategies. Current monitoring systems operate on a coarse grid with limited sensors that only target specific trace gases, leading to the omission of critical pollutants like ammonia. This results in costly, complex, and inefficient monitoring.MULTI TRACE introduces the world's ",{"id":23,"funder":7,"programme":8,"title":24,"piName":10,"institution":25,"country":26,"year":13,"amount":14,"abstract":27},"cordis-european-research-council-award-101248529","METABIOGEL","UNIVERSITY OF BRISTOL","UK","Our proposal aims to develop a new class of biobased composite hydrogel materials specifically designed for vibration damping and energy absorption applications. These biobased composites will be sourced locally from various regions worldwide and will serve as 3D printable feedstock. The new hydrogels will be engineered to withstand temperature and humidity ranges beyond typical room conditions and provide superior damping performance compared to fossil elastomeric materials available. As fully ",{"id":29,"funder":7,"programme":8,"title":30,"piName":10,"institution":31,"country":32,"year":13,"amount":14,"abstract":33},"cordis-european-research-council-award-101248647","Sleep Enhancement with Portable Temporal Interference Neuromodulation","LINKOPINGS UNIVERSITET","SE","SLEEP-TI proposes a new approach to address widespread sleep disorders and enhance sleep quality through non-invasive neuromodulation. Leveraging the innovative Temporal Interference (TI) technology, SLEEP-TI aims to develop a portable, user-friendly device capable of modulating specific brain regions associated with sleep regulation and memory consolidation, without the need for invasive procedures or the limitations of traditional sleep therapy methods.Poor sleep quality and sleep disorders su",{"id":35,"funder":7,"programme":8,"title":36,"piName":10,"institution":37,"country":12,"year":13,"amount":14,"abstract":38},"cordis-european-research-council-award-101248363","Molecularly Imprinted Photoactive Microswimmers for PFAS Capture and Detection","FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA","Per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, are persistent organic pollutants of global environmental concern with serious health risks. Their extensive industrial use and toxic effects have led to the implementation of stringent regulations worldwide, highlighting the urgent need for more efficient and sensitive PFAS detection technologies. Current detection methods are often inefficient, time-consuming, and lack the sensitivity required for trace-level anal",{"id":40,"funder":7,"programme":8,"title":41,"piName":10,"institution":42,"country":43,"year":13,"amount":14,"abstract":44},"cordis-european-research-council-award-101248681","Innovation in Hydrogen Production Energy Efficiency: A Three-Phase Electrolyser","TECHNISCHE UNIVERSITAET DRESDEN","DE","The 3P-EL project focuses on developing a three-phase electrolyser which represents a groundbreaking innovation in hydrogen production technology. By overcoming the fundamental limitations of traditional methods, it provides a more sustainable, cost-effective, and energy-efficient solution. The invention’s scalability and compatibility with renewable energy sources position it as a transformative tool in advancing the global transition to a hydrogen-based green energy economy, enhancing its comp",{"id":46,"funder":7,"programme":8,"title":47,"piName":10,"institution":48,"country":12,"year":13,"amount":14,"abstract":49},"cordis-european-research-council-award-101241930","Cooperative Optimal Control of Solar Plants","ASOCIACION DE LA INVESTIGACION Y COOPERACION INDUSTRIAL DE ANDALUCIA F. DE PAULA ROJAS\"","The main objective is to demonstrate that the Multiple Scenario Cooperative Model Predictive Control (MSC-MPC) algorithms developed under the Advanced Grant OCONTSOLAR can be effectively applied to optimize the production of commercial solar plants.This proposed PoC aims to validate the MSC-MPC algorithms developed in OCONTSOLAR not only for the solar field for the entire solar power plant. The proposal addresses optimal scheduling and control while accounting for the intermittent and stochastic",{"id":51,"funder":7,"programme":8,"title":52,"piName":10,"institution":53,"country":54,"year":13,"amount":14,"abstract":55},"cordis-european-research-council-award-101248180","Integrating behavioural insights and machine learning for smarter regulatory interventions","BAR ILAN UNIVERSITY","IL","Effective regulatory decision-making is essential for addressing complex societal challenges, yet current approaches often rely on intuition and standardized solutions that fail to account for behavioral, cultural, and contextual factors. BEHAVREG will transform regulatory governance by developing an innovative decision aid tool that integrates machine learning with behavioral science to predict likely compliance outcomes of regulatory choices and enable more effective intervention design. This ",{"id":57,"funder":7,"programme":8,"title":58,"piName":10,"institution":59,"country":43,"year":13,"amount":14,"abstract":60},"cordis-european-research-council-award-101248574","Real-World Application and Evaluation of Theoretically-Sound Cryptography","BERGISCHE UNIVERSITAET  WUPPERTAL","Cryptography is the foundation of modern communication: privacy, critical infrastructure, and the digitization of industry, economy, and healthcare depend on it. The transition to post-quantum cryptography (PQC) introduces both opportunities and challenges. Advancements in the design of post-quantum primitives have been significant, their concrete deployment in protocols remains challenged by real-world implementation constraints, security concerns, and interoperability challenges.This project b",{"id":62,"funder":7,"programme":8,"title":63,"piName":10,"institution":64,"country":43,"year":13,"amount":14,"abstract":65},"cordis-european-research-council-award-101247604","OPENing biological barriers using Shell-Engineered Shape-Adaptable Microbubble Enhancers","UNIVERSITAETSKLINIKUM AACHEN","OPEN-SESAME will assess the technical and commercial feasibility of a modular microbubble platform technology to enhance the delivery of drugs across biological barriers. The project aims to: (i) establish a robust and scalable synthesis protocol for producing shell- and shape-optimized polymeric microbubbles; (ii) evaluate the preclinical performance of our ultrasound-responsive microbubble enhancers in brain and tumor mouse models; (iii) strengthen our intellectual property (IP) position throu",{"id":67,"funder":7,"programme":8,"title":68,"piName":10,"institution":69,"country":70,"year":13,"amount":14,"abstract":71},"cordis-european-research-council-award-101247425","Cube satellite embedding pyroelectric modules to harvest energy in space","LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY","LU","Can we find new sources of energy in space? This project aims to explore pyroelectric materials as an alternative or complement to photovoltaic panels. Unlike solar panels, which require continuous sunlight, pyroelectric energy harvesters convert thermal variations into electricity, offering an alternative energy solution in space.For the first time, this study will assess the potential of pyroelectric energy harvesters directly in space. Pyroelectric modules will be selected, prepared, mounted ",{"id":73,"funder":7,"programme":8,"title":74,"piName":10,"institution":75,"country":20,"year":13,"amount":14,"abstract":76},"cordis-european-research-council-award-101248662","Integrated optical coupling for low loss electro-optic interconnects","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","The development of electrooptic transducers, that can effectively interface between microwave and optical frequencies, is critical to upcoming quantum technologies, such as distributed quantum computing over multiple superconducting qubit processors and the inclusion of any microwave-based quantum technologies in a future quantum internet. These transducers would furthermore also benefit classical applications where sensitive all-optical detection of microwave and THz frequency signals is benefi",{"id":78,"funder":7,"programme":8,"title":79,"piName":10,"institution":80,"country":81,"year":13,"amount":14,"abstract":82},"cordis-european-research-council-award-101246459","Mechanism-based influenza neuraminidase inhibitors as antivirals to combat flu infections","UNIVERSITEIT LEIDEN","NL","Influenza neuraminidases are the primary target for anti-influenza small molecule drugs and are retaining glycosidases that form a transient covalent intermediate during substrate hydrolysis. Oseltamivir (Tamiflu) and Zanamivir (Relenza), the two small-molecule anti-influenza drugs used primarily for early onset treatment of flu infections, inhibit influenza neuraminidases competitively (and thus reversibly). The AziFlu ERC PoC proposal is rooted in our finding that N-acyl Oseltamivir aziridines",{"id":84,"funder":7,"programme":8,"title":85,"piName":10,"institution":86,"country":54,"year":13,"amount":14,"abstract":87},"cordis-european-research-council-award-101247823","ACHIEVE: Development of an oral ACG-based treatment to combat obesity, maintain long-term dieting success and improve metabolic health","WEIZMANN INSTITUTE OF SCIENCE","Obesity constitutes an alarming global epidemic, exposing billions of individuals to a multitude of metabolic, infectious, & neoplastic health ramifications. While weight reducing interventions of the GLP-1 family are transforming medical weight reductive therapy, long-term weight loss maintenance remains a daunting unmet challenge, with most medically treated individuals rebounding to obesity. In our project, we will generate a first-of-its kind solution to this global need that will involve or",{"id":89,"funder":7,"programme":8,"title":90,"piName":10,"institution":91,"country":92,"year":13,"amount":14,"abstract":93},"cordis-european-research-council-award-101213783","Explainable Anomaly Detection for Safeguarding and Enhancing Modern Data Industry","ECOLE POLYTECHNIQUE","FR","In the ExplainableAD project, we address the problem of eXplainable Anomaly Detection (XAD) on data streams with evolving, previously unknown, complex anomaly types. To bridge the gap between growing demands in the data industry and severely limited industry-grade solutions available today, we propose a breakthrough XAD system that offers unprecedented capabilities for safeguarding digital services. To this end, it seamlessly integrates deep learning-based anomaly detection (AD), which unlocks t",{"id":95,"funder":7,"programme":8,"title":96,"piName":10,"institution":97,"country":43,"year":13,"amount":14,"abstract":98},"cordis-european-research-council-award-101188883","Stable Polariton LiDAR","UNIVERSITAT ZU KOLN","In the realm of advanced optical systems, particularly within the emerging field of Light Detection and Ranging (LiDAR) technology, which are pivotal for 3D sensing applications across various sectors, a significant commercial challenge emerges from the inherent limitations posed by optical interference in thin-film filters. The core of this challenge lies in the phenomenon known as 'angular dispersion,' a fundamental constraint of interference-based structures in thin-film filter design. Angula",{"id":100,"funder":7,"programme":8,"title":101,"piName":10,"institution":102,"country":103,"year":13,"amount":14,"abstract":104},"cordis-european-research-council-award-101247884","HYbrid hydrogels based on 2D materials and conducting polymers for piezoresistive SENSing","POLITECNICO DI TORINO","IT","Hypertension and cardiovascular diseases remain major global health challenges, yet current blood pressure (BP) monitors are bulky and provide only intermittent readings. The HYSENS project seeks to revolutionize wearable BP monitoring by developing advanced piezoresistive sensors based on hybrid hydrogels. Our innovative hydrogels integrate functional 2D nanomaterials (e.g., MoS2) and conductive polymers (e.g., polyaniline) into a biocompatible matrix, achieving high sensitivity, excellent dura",{"id":106,"funder":7,"programme":8,"title":107,"piName":10,"institution":102,"country":103,"year":13,"amount":14,"abstract":108},"cordis-european-research-council-award-101189419","TURBOEEG: A fast open-source brain imaging package for electroencephalography","Electroencephalography (EEG) from scalp potentials is a crucial non-invasive technique for imaging the electric brain activity. EEG is of primary importance in several scenarios of substantial societal impact ranging from electric characterization of epileptic seizures to the development of brain computer interfaces.One of the key technologies in advanced EEG imaging is the source imaging\u002Flocalization procedure where the volume electric current responsible for the scalp potential is obtained sol",{"id":110,"funder":7,"programme":8,"title":111,"piName":10,"institution":102,"country":103,"year":13,"amount":14,"abstract":112},"cordis-european-research-council-award-101213773","Glycerol and nItrogeN conversioN through electrochemistrY","The current climate crisis, caused by greenhouse gas emissions, urgently requires sustainable chemical processes. Ammonia, a critical chemical for fertilizers as well as an emerging energy carrier, has a significant role in the transition to renewable energy due to its high hydrogen content and energy density. However, the conventional Haber-Bosch process for ammonia production is highly energy-consuming and polluting. My ongoing ERC-StG is dealing with lithium-mediated electrochemical nitrogen ",{"id":114,"funder":7,"programme":8,"title":115,"piName":10,"institution":116,"country":81,"year":13,"amount":14,"abstract":117},"cordis-european-research-council-award-101212785","Scaling up dissipative metamaterials for energy absorption applications","UNIVERSITEIT VAN AMSTERDAM","Preventing thermal run-away (resulting in fire) of batteries in electrical vehicles which can result from impingement of the protecting battery box during side impact collisions is a critical design consideration for vehicle safety. This challenge requires a careful trade-off between the shock-absorbing capabilities and the lightness of the material to ensure both safety and efficiency in vehicle design. We have developed a new class of mechanical metamaterials that are lightweight and highly di",{"id":119,"funder":7,"programme":8,"title":120,"piName":10,"institution":121,"country":122,"year":13,"amount":14,"abstract":123},"cordis-european-research-council-award-101213805","Widely Tunable Soliton Microcomb Chip","DANMARKS TEKNISKE UNIVERSITET","DK","The generation of optical frequency combs through nonlinear optical processes is an enabling technology for a wide range of applications. These combs, consisting of equally spaced coherent light frequencies, are highly valued in applications such as communications, LiDAR, and microwave photonics. The first generation of combs, developed using mode-locked lasers, expanded their spectrum through nonlinear media to create broadband frequency combs. Initially, these systems relied on bulky free-spac",{"id":125,"funder":7,"programme":8,"title":126,"piName":10,"institution":121,"country":122,"year":13,"amount":14,"abstract":127},"cordis-european-research-council-award-101248640","Celloop - Centrifugal Perfusion Gut-on-Chip: A Scalable, Pump-Free Platform for Predictive Drug Testing and Preclinical Innovation","This project aims to validate the Centrifugal Perfusion Gut-on-Chip (CPGoC) system, offering a low-cost, pump-free, and user-friendly alternative to existing microfluidic systems for drug absorption studies. Unlike traditional models, CPGoC uses centrifugal force to drive continuous perfusion, closely mimicking physiological fluid flow and nutrient transport in the human intestine. Thus, it eliminates the need for external pumps and tubing, reducing costs, contamination risks, and technical barr",{"id":129,"funder":7,"programme":8,"title":130,"piName":10,"institution":121,"country":122,"year":13,"amount":14,"abstract":131},"cordis-european-research-council-award-101205606","Thermal Conversion and Storage in One Solid-State Device","Waste heat makes up a very large fraction of the energy produced today. The process chain of energy conversion of chemical energy into power is subject to up to 72% loss. Recovering this waste heat will be crucial for enhancing the efficiency of processes. Today approaches such as thermoelectric energy conversion are receiving interest due to their ability to turn waste energy back into useful electrical energy. However, the wider adoption of this technology is being held back due to the low eff",{"id":133,"funder":7,"programme":8,"title":134,"piName":10,"institution":121,"country":122,"year":13,"amount":14,"abstract":135},"cordis-european-research-council-award-101212669","Implementation of Super-resolution Ultrasound Real-time micro-vascular Imaging using Erythrocytes - iSURE","The Proof-of-Concept project will develop the hardware and software architecture for a novel ultrasound scannercapable of performing real-time 3-D super-resolution imaging of the microcirculation in humans. The scanner is based onthe methods developed in the SURE ERC synergy grant project for Super-resolution Ultrasound Real-time imaging usingErythrocytes (SURE). The approach can non-invasively visualize the microvascular structures in the human body for vesseldiameters down to 28 μm from data a",{"id":137,"funder":7,"programme":8,"title":138,"piName":10,"institution":121,"country":122,"year":13,"amount":14,"abstract":139},"cordis-european-research-council-award-101212907","ENABLING THE PREVENTION OF REBOUND EFFECTS OF SUSTAINABILITY-ORIENTED POLICIES","Never before has there been a stronger global focus on the development of sustainability-oriented policies. Nevertheless, ca. 47% of their potential sustainability gains are never achieved due to rebound effects, negative consequences of sustainability-oriented interventions due to behavioural and systemic changes.REBOUNDLESS POLICIES aims to develop, test and demonstrate a comprehensive toolbox for the identification, simulation, and prevention of potential rebound effects of sustainability-ori",{"id":141,"funder":7,"programme":8,"title":142,"piName":10,"institution":143,"country":43,"year":13,"amount":14,"abstract":144},"cordis-european-research-council-award-101212809","Enabling Fermionic Quantum Processing for Chemistry","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","The determination of ground states of many interacting fermions is a key application for future quantum computers with significant implications for the design of new materials and the prediction of reaction pathways in chemistry. Recently, we put forward the proposal Simulating Chemistry with Fermionic Optical Superlattices, establishing ultracold fermions in optical lattices as a promising computational platform for this task. This approach uses the hard-wired fermionic symmetries of ultracold ",{"id":146,"funder":7,"programme":8,"title":147,"piName":10,"institution":143,"country":43,"year":13,"amount":14,"abstract":148},"cordis-european-research-council-award-101213618","Your Future You:  An Intelligent Conversational Agent to Increase Future Orientation and Decrease Self-defeating Behavior","This PoC action harnesses the potential of artificial intelligence (AI) to enhance future orientation and mental well-being, and to mitigate self-defeating behaviors. Building on recent evidence that future-oriented thinking —a key factor in academic performance, health, wealth, and goal achievement— can be stimulated, we aim to address the scaling and impact-related challenges of existing interventions. Leveraging the power of AI-powered large language models (LLMs), our proposed solution is to",{"id":150,"funder":7,"programme":8,"title":151,"piName":10,"institution":152,"country":32,"year":13,"amount":14,"abstract":153},"cordis-european-research-council-award-101247527","Safety and Mobility Optimization via Virtual Environments Lab","LUNDS UNIVERSITET","SafeMoVE addresses critical gaps in road safety assessment methods, particularly as they pertain to mixed traffic scenarios involving connected and automated vehicles, vulnerable road users, and conventional road users. Building on the scientific advancements of SUperSAFE, SafeMoVE aims to validate and commercialize a universal, proactive methodology for traffic safety analysis. Unlike traditional approaches reliant on historical accident data, the proposed framework employs Extreme Value Theory",{"id":155,"funder":7,"programme":8,"title":156,"piName":10,"institution":157,"country":81,"year":13,"amount":14,"abstract":158},"cordis-european-research-council-award-101248694","Intensity Modulated Photoluminescence Spectroscopy for Stable Perovskite Solar Cells","STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN","The solar cell industry already has an annual value of 200 billion US dollars and is expected to triple in the coming ten years. Within that period, an emerging solar cell material – halide perovskite – is projected to capture 20% of the market, by being used in combination with current market-leading silicon solar cells. While the efficiency of this emerging solar material is outstanding, ionic migration that occurs during solar cell operation leads to poor stability, which is the main factor l",{"id":160,"funder":7,"programme":8,"title":161,"piName":10,"institution":162,"country":43,"year":13,"amount":14,"abstract":163},"cordis-european-research-council-award-101248686","High-Precision Continuous Polar Borehole Temperature Monitoring System","ALFRED-WEGENER-INSTITUT HELMHOLTZ-ZENTRUM FUR POLAR- UND MEERESFORSCHUNG","The Earth’s climate system is experiencing an accelerating energy imbalance, with unprecedented heat accumulation driving rapid transformations across the ocean, land, cryosphere, and atmosphere. Despite the critical need for high-precision subsurface ice and soil temperature measurements—to assess land energy storage1, reconstruct past climate evolution2,3, refine ice models4, and determine permafrost stability5 — existing solutions are either insufficiently precise, prohibitively expensive, or",{"id":165,"funder":7,"programme":8,"title":166,"piName":10,"institution":167,"country":26,"year":13,"amount":14,"abstract":168},"cordis-european-research-council-award-101211578","THINK DEEP: Novel arts-based resources to reIMAGINE Artisanal Mining?","ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE","THINK DEEP: IMAGINE?’s unique value proposition lies in its innovative arts-based response to the pressing challenge of ‘thinking differently’ about Artisanal and Small-Scale Mining (ASM). In 2019 the World Bank envisioned a new future for ASM in which this challenging sector escapes its persistently negative stereotypes to realise its central place within global development in socially and environmentally just ways. Such a vision is neither without controversy nor easy to achieve as ASM is plag",{"id":170,"funder":7,"programme":8,"title":171,"piName":10,"institution":172,"country":12,"year":13,"amount":14,"abstract":173},"cordis-european-research-council-award-101204328","Magneto-ionic data-security device integrated on flexible substrates","UNIVERSITAT AUTONOMA DE BARCELONA","Traditional methods of safeguarding data often fall short in today’s rapidly evolving information technology landscape. Passwords are vulnerable to hacking, and while encryption offers enhanced security, it significantly increases data processing costs and slows performance. Storing secret keys in battery-backed memory is also inefficient in terms of energy consumption. The advent of physical unclonable functions (PUFs), which create unique device fingerprints based on random physical properties",{"id":175,"funder":7,"programme":8,"title":176,"piName":10,"institution":177,"country":81,"year":13,"amount":14,"abstract":178},"cordis-european-research-council-award-101188053","DNA Encryption of Compartmentalized DNA Files","TECHNISCHE UNIVERSITEIT EINDHOVEN","Current technologies for digital data storage (e.g., tapes and hard disc drives) have hit various sustainability limits. A significant share of new data is not stored beyond the short term, and conventional storage media do not have the longevity, data density or cost efficiency to meet global demand. Longer-term projections forecast that the overall demand for digital storage will exceed supply by up to three orders of magnitude by 2040. DNA data storage has several advantages compared to magne",{"id":180,"funder":7,"programme":8,"title":181,"piName":10,"institution":182,"country":26,"year":13,"amount":14,"abstract":183},"cordis-european-research-council-award-101247887","SOCial Impact Assessment Tool for Nature Protection and Restoration Policies","UNIVERSITY OF WARWICK","The SOCIAT project aims to develop an innovative, interactive platform for social impact assessment in nature conservation policies. This tool addresses the growing need for accurate, accessible, and standardized assessments of the socio-economic effects of biodiversity policies and restoration initiatives. Despite increasing commitments to conservation, existing methods lack consistency, predictive capabilities, and ease of application across multiple contexts. Building on the ERC-funded FIDELI",{"id":185,"funder":7,"programme":8,"title":186,"piName":10,"institution":187,"country":81,"year":13,"amount":14,"abstract":188},"cordis-european-research-council-award-101247813","Structural biology tools for Antibiotic Research","UNIVERSITEIT UTRECHT","Antimicrobial resistance (AMR) is escalating due to multidrug-resistant (MDR) bacteria and a dwindling antibiotic pipeline and is projected to cause up to 10 million deaths annually by 2050. Lipid-targeting (LT) antibiotics such as daptomycin and polymyxins combat MDR infections by disrupting bacterial membranes, yet their mechanisms remain unclear due to major technical challenges for structural biology. This knowledge gap hinders the development of next-generation LT-antibiotics with improved ",{"id":190,"funder":7,"programme":8,"title":191,"piName":10,"institution":187,"country":81,"year":13,"amount":14,"abstract":192},"cordis-european-research-council-award-101247918","In vitro & biodistribution analysis of morphology-controlled polymeric gene delivery nanocarriers (POLYMORPH)","Gene therapy holds the potential to be an enabling technology to truly cure (rare) diseases by directly correcting errors in the patient’s genetic database underlying the disorder. For these corrections therapeutic nucleic acids (NAs) are typically used. However, the precise and efficient delivery of these NAs remains a critical bottleneck, hindering the full-scale clinical implementation of gene therapy. NAs are large, highly charged and unstable molecules, hampering transport and passing (intr",{"id":194,"funder":7,"programme":8,"title":195,"piName":10,"institution":196,"country":81,"year":13,"amount":14,"abstract":197},"cordis-european-research-council-award-101213048","The pursuit of non-invasive treatment for intracranial aneurysms to PRevent aneurYSMal subarachnoid hemorrhage","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","Rupture of intracranial aneurysms (IA) results in aneurysmal subarachnoid hemorrhage (aSAH), an often fatal type of stroke. Invasive IA treatment to prevent aSAH is a high-risk procedure, limiting its use and leaving most IA patients untreated. Thus, there is an urgent need for non-invasive drugs preventing aSAH, but these are lacking as our understanding of the causal disease pathways is poor. The considerable female predominance in IA and aSAH suggests the existence of sex-specific regulation ",{"id":199,"funder":7,"programme":8,"title":200,"piName":10,"institution":201,"country":26,"year":13,"amount":14,"abstract":202},"cordis-european-research-council-award-101248385","AbSorber of Topological electRomagnetic wAves","UNIVERSITY OF SOUTHAMPTON","Recent advances in controlling the topological structure of light open up opportunities for new information and energy carriers with applications from telecommunications and spectroscopy to metrology, imaging, and remote sensing. However, despite the application potential of topologically structured light, its generation and detection remains a complex and challenging task that hinders practical applications. In our earlier ERC FLEET project, we developed methods for the generation and detection",{"id":204,"funder":7,"programme":8,"title":205,"piName":10,"institution":206,"country":122,"year":13,"amount":14,"abstract":207},"cordis-european-research-council-award-101212927","Identification of viroporin blockers for future antiviral therapy using automated high-throughput screening","KOBENHAVNS UNIVERSITET","The potential for future viral pandemics to trigger a global crisis underscores the urgent need for the development of new antiviral drugs. Viroporins, identified in several RNA virus families, form pores\u002Fion channels in cell and\u002For virus membranes, contributing to the virus life cycle and virus-induced pathology. Blocking viroporins with small-molecule compounds has proven to be an effective therapeutic strategy. However, the clinical success of these viroporin blockers has been limited due to ",{"id":209,"funder":7,"programme":8,"title":210,"piName":10,"institution":206,"country":122,"year":13,"amount":14,"abstract":211},"cordis-european-research-council-award-101189401","APPMONITOR: A toolkit for monitoring third-party tracking across iOS and Android apps","APPMONITOR addresses the critical need for means and measures to monitor digital tracking and datafication by third-parties in mobile apps in Europe, building on the ERC StG DATAFIED LIVING. With EU implementing powerful regulations to curb unwanted and illegitimate collection, mining, and compilation of user data across digital technologies, member states now have a strong political mandate to regulate the booming data economy. Yet, the successful enforcement of these schemes relies on the intr",{"id":213,"funder":7,"programme":8,"title":214,"piName":10,"institution":206,"country":122,"year":13,"amount":14,"abstract":215},"cordis-european-research-council-award-101189502","The PUPILLO tracker: next generation eye tracking","Eye-tracking is one of the most valuable tools for measuring human behaviour, applicable to multiple populations and stages of development, and their use has enjoyed an exponential increase both within and outside of research. Pupil size, measurable with eye-trackers, provides a valuable index of a wide range of cognitive functions. However, pupillometry has significant untapped potential because current commercial eye-trackers are unable to provide reliable indications of cognitively driven pup",{"id":217,"funder":7,"programme":8,"title":218,"piName":10,"institution":219,"country":220,"year":13,"amount":14,"abstract":221},"cordis-european-research-council-award-101213658","Low-loss fiber coupler","INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM","BE","This ERC Proof of Concept (PoC) project aims to demonstrate a low-loss fibre-to-chip coupler, a critical component for the PI’s ERC project QAMP (101042414). While QAMP focuses on achieving unity electro-optical transduction to convert superconducting qubits to optical qubits, the realized product requires an efficient fibre-to-chip coupler to extract the optical qubits. Our patented innovation introduces a fibre-to-chip coupler with unprecedented low losses of 0.015 dB (0.35%), which is an orde",{"id":223,"funder":7,"programme":8,"title":224,"piName":10,"institution":219,"country":220,"year":13,"amount":14,"abstract":225},"cordis-european-research-council-award-101213665","On-chip tunable perovskite laser in the visible\u002Fnear-infrared range","The availability of a tunable laser source in the visible and near-infrared (NIR) range is crucial for a variety of high-impact applications, such as frequency-modulated continuous wave LiDAR, optical coherence tomography, quantum photonics, and molecular spectroscopy. Despite the demand, current solutions for tunable lasers in these wavelength ranges remain limited, both in terms of availability and performance. Metal halide perovskite thin films are emerging as highly promising materials for s",{"id":227,"funder":7,"programme":8,"title":228,"piName":10,"institution":229,"country":26,"year":13,"amount":14,"abstract":230},"cordis-european-research-council-award-101213994","Terahertz Spin Wave Logic","UNIVERSITY OF LANCASTER","Finding a fundamentally new approach for data processing in the fastest and most energy efficient way is a frontier problem for applied physics and technology. The amount of data generated every second is so enormous that the heat produced by modern data centres has already become a serious limitation to further increase their performance. This heating is a result of the Ohmic dissipation of energy unavoidable in conventional electronics. At present, the data industry lacks a solution for this p",{"id":232,"funder":7,"programme":8,"title":233,"piName":10,"institution":234,"country":12,"year":13,"amount":14,"abstract":235},"cordis-european-research-council-award-101213225","Inclusive artificial intelligence using adaptive federated learning across high- and low-resource settings","UNIVERSITAT DE BARCELONA","The AIFIX project is a transformative initiative aiming to bridge the healthcare AI divide by developing an adaptive federated intelligence platform to securely integrate medical imaging data across diverse environments. It specifically targets the inclusion of low- and middle-income countries (LMICs), where limited data availability, privacy concerns, and inadequate legal frameworks have traditionally hindered AI innovation in healthcare.AIFIX will deliver an adaptive federated learning platfor",{"id":237,"funder":7,"programme":8,"title":238,"piName":10,"institution":239,"country":103,"year":13,"amount":14,"abstract":240},"cordis-european-research-council-award-101213818","Monitoring crustal stress state frOm 4D sEismic iMaging","UNIVERSITA DEGLI STUDI DI PADOVA","Tectonically active crustal settings such as volcanic fields and seismogenic fault systems are characterized by evolving stress critical conditions that can be detected by continuously measuring isotropic and, more importantly, anisotropic elastic properties. This is because these observables are strongly sensitive to the opening of fractures and to the infiltration and migration of magma and crustal fluids, which are more prominent before major volcanic eruptions and earthquakes. With this resp",{"id":242,"funder":7,"programme":8,"title":243,"piName":10,"institution":244,"country":92,"year":13,"amount":14,"abstract":245},"cordis-european-research-council-award-101247569","Discovering and Deploying Evolution's Solutions for Microplastic Degradation","INSTITUT PASTEUR","Microplastics represent an emerging global health crisis, with nearly 500 million people directly impacted worldwide. Current solutions for plastic waste management are inadequate, with degradation into microplastics (\u003C5mm) and nanoplastics (\u003C1μm) creating pervasive contamination. These particles have been detected in human tissues including the brain, gut, arteries, placenta, and breast milk, with evidence linking them to inflammatory conditions, hormone disruption, and increased disease risk.T",{"id":247,"funder":7,"programme":8,"title":248,"piName":10,"institution":249,"country":43,"year":13,"amount":14,"abstract":250},"cordis-european-research-council-award-101213985","Decoding and training spared motor neuron activity in children with paralyzed hands","FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG","We have recently identified single motor neuron activity in humans with spinal cord injury and stroke resulting in complete loss of hand function. We have then demonstrated that these individuals can control with high levels of precision the spared motor neurons ensemble in real-time, up to four degrees of freedom of the hand. We have now collected pilot data in children (\u003C4 years old) with a completely paralyzed hand and we also found spared electromyographic activity when the children were pla",{"id":252,"funder":7,"programme":8,"title":253,"piName":10,"institution":254,"country":220,"year":13,"amount":14,"abstract":255},"cordis-european-research-council-award-101244020","Macro-Social Turn in Labour Market Inequality: An Open Database and A Toolkit of Unpaid Labour","KATHOLIEKE UNIVERSITEIT LEUVEN","In my ERC AdG (ResPectMe) I developed a survey module of unpaid labour that was implemented through nation-wide panel surveys in Sweden (Lore), France (ELIPSS), The Netherlands (LISS) & UK (NatCen). With this PoC (ReSTLess) I will harness and maximize the utility of this survey module along three dimensions: time (work hours, incl. time to maintain, prepare, travel for work), material (office spaces, smart phone, software, PCs, other infrastructures), immaterial assets (emotions, feelings, knowl",{"id":257,"funder":7,"programme":8,"title":258,"piName":10,"institution":259,"country":103,"year":13,"amount":14,"abstract":260},"cordis-european-research-council-award-101247256","SAFE authentication through PRInted and Non-reproducible drop-based Technology","QUANTAVIS SRL","SAFEPRINT introduces a transformative approach to product authentication by developing cost-effective, high-entropy Physical Unclonable Functions (PUFs) based on ink droplet deposition. Building upon breakthroughs obtained in the ERC projects PEP2D and PREPRINT, this technology leverages the inherent randomness of drop deposition to create unique, unclonable security features that can deliver way higher entropy than current market solutions while reducing implementation costs. The project advanc",{"id":262,"funder":7,"programme":8,"title":263,"piName":10,"institution":264,"country":103,"year":13,"amount":14,"abstract":265},"cordis-european-research-council-award-101247526","Label-free fluorescence lifetime analysis for the screening of nanoencapsulated drugs","SCUOLA NORMALE SUPERIORE","Nanomedicine has the potential to revolutionize healthcare by enabling targeted drug delivery, reducing side effects, and improving treatment efficacy. However, the field faces a critical bottleneck: the lack of efficient, non-invasive analytical tools to assess drug encapsulation, stability, and release dynamics in nanoformulations. Current techniques rely on destructive, time-consuming methods, limiting their applicability in formulation development and quality control.enLIGHT introduces a bre",{"id":267,"funder":7,"programme":8,"title":268,"piName":10,"institution":269,"country":92,"year":13,"amount":14,"abstract":270},"cordis-european-research-council-award-101248616","Benchtop DNP polarizer enabling highly sensitive  hyperpolarized NMR analysis","UNIVERSITE LYON 1 CLAUDE BERNARD","Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical technique in chemistry, pharmaceuticals, and metabolomics, but requires complex and expensive infrastructure, limiting its widespread adoption. Since recently, the development of Benchtop NMR spectrometers offers a simple, compact, and low-cost alternative compared to traditional high-field systems, and their market has seen a significant growth. However, benchtop NMR faces a critical restraint which is its order of magnitude",{"id":272,"funder":7,"programme":8,"title":273,"piName":10,"institution":274,"country":103,"year":13,"amount":14,"abstract":275},"cordis-european-research-council-award-101248056","Chirality detection enabled by colossal optical anisotropy of 2D layered materials","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","Molecular chirality plays a fundamental role in pharmaceuticals, toxicology, and environmental sciences, as enantiomers of the same molecule can have vastly different biological effects. Current chiroptical detection methods, such as circular dichroism and Raman optical activity, require complex, expensive setups with limited sensitivity, often making real-time and field applications impractical. The 2Dchiral project aims to revolutionize chiral detection by leveraging the colossal optical aniso",{"id":277,"funder":7,"programme":8,"title":278,"piName":10,"institution":279,"country":43,"year":13,"amount":14,"abstract":280},"cordis-european-research-council-award-101248128","CLOsing the loOP on non-invasive brain sTiMulation with deep neural networkS (LOOP-TMS)","EBERHARD KARLS UNIVERSITAET TUEBINGEN","We aim to develop and validate adaptive closed-loop brain stimulation using advanced real-time electroencephalography-transcranial magnetic stimulation (EEG–TMS) technology guided by probabilistic deep artificial neural networks. TMS is performed routinely worldwide in tens of thousands of healthcare institutions for treating a wide variety of brain disorders. However, current TMS protocols are limited by small therapeutic effect sizes and large portions of non-responders. A significant problem ",{"id":282,"funder":7,"programme":8,"title":283,"piName":10,"institution":284,"country":26,"year":13,"amount":14,"abstract":285},"cordis-european-research-council-award-101247299","Augmented PhOtovoltaic ceLLs-based Optical Neural networks for environmental monitoring","THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS","APOLLON aims to develop a novel solar-cell-based optical neural network (ONN) designed for real-time, energy-efficient environmental monitoring and object recognition. By leveraging solar cells as both sensors and network nodes, the ONN eliminates the need for conventional cameras and external power sources, significantly reducing energy consumption and system complexity. The integration of metasurfaces enhances the system’s optical sensitivity and spectral selectivity, enabling more accurate de",{"id":287,"funder":7,"programme":8,"title":288,"piName":10,"institution":289,"country":32,"year":13,"amount":14,"abstract":290},"cordis-european-research-council-award-101212898","Pneu-Haptics: Unlocking the Potential of a Haptic Cueing System for Driver Communication, Collaboration and Control with (Semi-) Autonomous Vehicles","KUNGLIGA TEKNISKA HOEGSKOLAN","There is an on-going societal shift from manual vehicles to semi-autonomous vehicles, which will fundamentally alter the practical, emotional and somatic experience of driving cars, trucks, trains, and even tractors. At the same time, innovations in strategies for communicating with the driver have not advanced beyond the utilization of visual and audio modalities. As the driving experience becomes more complex this has led to an overwhelming cognitive experience consisting of excessive blinking",{"id":292,"funder":7,"programme":8,"title":293,"piName":10,"institution":294,"country":32,"year":13,"amount":14,"abstract":295},"cordis-european-research-council-award-101212948","Global-Ig: a population-based antibody library technique to optimize the development of globally protective vaccines","KAROLINSKA INSTITUTET","As the SARS-CoV-2 pandemic has demonstrated, vaccines that provide broad global protection are needed. However, human antibody genes are highly variable and thus, the quality of vaccine-induced responses can vary between population groups. This variation is shaped by the long history of host\u002Fdisease interactions and differences in endemic diseases between regions over time, resulting in differences in antibody allele frequencies between populations. Therefore, information about how naïve antibod",{"id":297,"funder":7,"programme":8,"title":298,"piName":10,"institution":299,"country":26,"year":13,"amount":14,"abstract":300},"cordis-european-research-council-award-101203795","Using Gradients of Connectivity to Predict Cognitive Impairment After Stroke","UNIVERSITY OF YORK","Many stroke survivors have chronic problems with language, attention, cognitive control and motor function. There is an urgent need to predict these sequelae so that rehabilitation can be better focussed, but it has proved challenging to anticipate the effects of stroke from brain lesions alone. We will use recent advances from our ERC-funded FLEXSEM project to predict the long-term consequences of stroke. Our work decomposes whole-brain connectivity patterns derived from resting-state functiona",{"id":302,"funder":7,"programme":8,"title":303,"piName":10,"institution":304,"country":305,"year":13,"amount":14,"abstract":306},"cordis-european-research-council-award-101213953","Accurate quantification of neurologic disease over time","OSLO UNIVERSITETSSYKEHUS HF","NO","A research discovery has little relevance if it never makes an impact on its target users. A key challenge for radiology is that very few diagnostic innovations end up changing clinical practice. Most clinical decision-making processes follow the same hypothesis-driven approach where the association between a biomarker and disease status are assessed by trial-and-error. By forcing the patients’ data into traditional paradigms, we are inherently making poor use of the available information. Moreo",{"id":308,"funder":7,"programme":8,"title":309,"piName":10,"institution":310,"country":103,"year":13,"amount":14,"abstract":311},"cordis-european-research-council-award-101213070","Scaling up Daytime Radiative Cooling: The new low-cost kit FOR REAListic and repeatable characterization across all climates","UNIVERSITA DEGLI STUDI DI PERUGIA","As the global population keeps growing and the effects of global warming intensify with relevant health implications, the demand for cooling is expected to more than triple by 2050. This surge in demand will not only double electricity consumption but also significantly increase CO2 emissions. Passive Daytime Radiative Cooling (PDRC) is acknowledged as a promising solution for regulating the Earth’s energy budget. By cooling objects through radiative heat emission into space without energy consu",{"id":313,"funder":7,"programme":8,"title":314,"piName":10,"institution":315,"country":92,"year":13,"amount":14,"abstract":316},"cordis-european-research-council-award-101208602","Multi-messenger AI-enhanced earthquake early warning","INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT","Earthquakes caused nearly one million fatalities in the last two decades and billions of euros of economic loss. In our current state of knowledge, these hazardous events remain unpredictable. Early Warning Systems (EWS) exist in some countries at risk, but they only send alerts once the earthquake has started, leveraging information recorded close to the epicenter before the most destructive seismic waves reach more distant populated areas. These systems provide – in the best-case scenarios – o",{"id":318,"funder":7,"programme":8,"title":319,"piName":10,"institution":80,"country":81,"year":13,"amount":14,"abstract":320},"cordis-european-research-council-award-101213839","SUPRAmolecular Hydrogel Driven Assembly of Designer Heart Tissues","The SUPRAHEART proof-of-concept project aims to use our squaramide-based (SQ) filamentous double network hydrogels for assembly of engineered heart tissues (EHTs). As the current dependency of EHTs on natural materials (e.g., collagen I, Matrigel) limits their large-scale application as cardiac models, their generation using a fully synthetic matrix will provide improved reproducibility, tunability and scalability, opening the door for their use as a high-throughput pharmaceutical testing platfo",{"id":322,"funder":7,"programme":8,"title":323,"piName":10,"institution":324,"country":220,"year":13,"amount":14,"abstract":325},"cordis-european-research-council-award-101213262","COunterfeit DEtection: Validating the ARTDETECT approach with Stakeholders in the loop","UNIVERSITEIT GENT","Forged paintings pose an urgent challenge to international law enforcement agencies and the art world. Both the quantity and the quality of the works are alarming. In practice, however, this type of art crime is notoriously difficult to detect and combat. The CoG project ARTDETECT is generating new knowledge about significant anomalies that betray forged paintings (as well as into key characteristics of comparable originals); and is developing ‘thin-slicing’ tools, i.e. computer programs and che",{"id":327,"funder":7,"programme":8,"title":328,"piName":10,"institution":329,"country":330,"year":13,"amount":14,"abstract":331},"cordis-european-research-council-award-101213756","Meteotsunami detection and tracking: Developing a solution based on assessment of real-time measurements","SEMPRE AVANTI DOO ZA SAVJETOVANJE I USLUGE","HR","Meteorological tsunamis (meteotsunamis) are long ocean waves (periods of: 1 \u003C T \u003C ~120 min) that have the same periods, wavelengths and amplitudes as seismic tsunamis, but are generated by processes in the atmosphere. Meteorological tsunamis occur all over the world. Although they are never nearly as destructive as seismic tsunamis, meteotsunamis occasionally cause destruction and loss of life. After several devastating events, firstly national authorities in several countries at risk, and then ",{"id":333,"funder":7,"programme":8,"title":334,"piName":10,"institution":335,"country":12,"year":13,"amount":14,"abstract":336},"cordis-european-research-council-award-101212926","Development of an immune-armed therapeutic adenoviral platform for pediatric brain tumors","UNIVERSIDAD DE NAVARRA","Diffuse Midline Gliomas (DMGs) are the most aggressive pediatric brain tumors in desperate need of curative treatment. The median life expectancy of these children remains below 14 months after diagnosis, and nearly none survive beyond the second year. Similarly, for other high-risk pediatric brain tumors, there is hardly any option after recurrence, and long-term survivors are faced with life-long sequelae that impact their quality of life. In this scenario, there is an urgent need for innovati",{"id":338,"funder":7,"programme":8,"title":339,"piName":10,"institution":340,"country":26,"year":13,"amount":14,"abstract":341},"cordis-european-research-council-award-101212602","Re-cleaneable SERS devices for Personalised Health and Environmental sensing","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","We have invented an optical enhancement technique based on surface-enhanced Raman scattering (SERS) using self-assembled gold nanostructures that can fingerprint a wide range of bioanalytes (neurotransmitters, hormones) at clinical concentrations in biofluids. Current SERS substrates suffer from poor repeatability, fouling from organics, and non-reusability, which is why they have not made it into biomedical use. We have developed a new capability to create precision nano-gap materials that trap",{"id":343,"funder":7,"programme":8,"title":344,"piName":10,"institution":274,"country":103,"year":13,"amount":14,"abstract":345},"cordis-european-research-council-award-101189387","Assessing childRen manIpulation and Exploration skiLls","Investigating object manipulation is crucial for the comprehension of child development and the early assessment of sensorimotor impairments. However, no current available methods allow a complete and widespread characterization of the process: (i) they do not measure all the core components of manipulation, such as the object motion and the forces applied; (ii) they are too expensive due to the cost of the devices or the need of expert annotators; (iii) they are not designed for children. ARIEL",{"id":347,"funder":7,"programme":8,"title":348,"piName":10,"institution":349,"country":81,"year":13,"amount":14,"abstract":350},"cordis-european-research-council-award-101203892","Circular X Accelerator (CXA)","UNIVERSITEIT MAASTRICHT","Advanced circularity strategies including sufficiency (reuse, refuse) and regeneration have not yet scaled up in business practice. More support is needed to accelerate this transition. The goal of the Circular X Accelerator (CXA) is to develop and scale advanced circular business models. Such business models have the potential to achieve significant environmental impact improvements compared to simply selling products. ERC Circular X pioneered research on experimentation with advanced circular ",{"id":352,"funder":7,"programme":8,"title":353,"piName":10,"institution":37,"country":12,"year":13,"amount":14,"abstract":354},"cordis-european-research-council-award-101189468","New chemical warheads for covalent drug discovery","Over the past two decades, the pharmaceutical industry has witnessed an exponential growth in approved covalent drugs. The majority of such drugs incorporate a chemical warhead, a mild electrophilic reactive functional group that forms covalent bonds in a reversible or irreversible manner with nucleophilic aminoacid residues. The aim of this proposal is to assess the viability of a new chemical warhead in the discovery of novel kinase inhibitors.",{"id":356,"funder":7,"programme":8,"title":357,"piName":10,"institution":196,"country":81,"year":13,"amount":14,"abstract":358},"cordis-european-research-council-award-101213366","Developing a Capture-Based Biomarker Assay Using cfDNA Methylation to Detect High-Risk Atherosclerotic Plaques in the Circulation","The holy grail in cardiology is to identify high-risk atherosclerotic plaques that may cause a myocardial infarction. This is especially relevant for women, who often experience misdiagnosis or delays in the diagnosis of coronary artery disease. Current diagnostic methods are invasive, expensive, and fail to provide precise and timely insights into the state of the plaque. The U-BiomarCAPTURE approach builds on insights from the ERC CoG UCARE and ERC PoC U-BiomarCARE projects, where we identifie",{"id":360,"funder":7,"programme":8,"title":361,"piName":10,"institution":362,"country":220,"year":13,"amount":14,"abstract":363},"cordis-european-research-council-award-101188851","Cortical Training to Improve Navigation for the Visually Impaired","UNIVERSITEIT ANTWERPEN","At the moment, in the European Union, there is very little support and virtually no training for blind people. But there are veryefficient modes of navigating one’s environment that blind people can learn and some of them can learn very easily,including: (1) Cone use, (2) Sensory substitution devices, (3) Echolocation.The problem is that the interpersonal variation in all these three techniques is huge. Some blind subjects pick up thesetechniques very quickly and use them efficiently, while othe",{"id":365,"funder":7,"programme":8,"title":366,"piName":10,"institution":367,"country":368,"year":13,"amount":14,"abstract":369},"cordis-european-research-council-award-101201887","Fighting Resistant Bacteria with Antimicrobial Peptides","Masarykova univerzita","CZ","Antimicrobial resistance (AMR) is a critical global health threat, associated with approximately 5 million deaths annually and a severe economic burden. To combat this threat, this project aims to advance the development of our de novo designed antimicrobial peptides (AMPs) towards novel therapeutics. These AMPs, developed within our ERC Consolidator project Peptide Killers of Bacteria, utilize a mechanism distinct from traditional antibiotics, namely the disruption of bacterial cell membranes. ",{"id":371,"funder":7,"programme":8,"title":372,"piName":10,"institution":373,"country":103,"year":13,"amount":14,"abstract":374},"cordis-european-research-council-award-101212897","Fusing LiDAR Observations with Remote-sensing Analysis for finding “beauty” in the city","UNIVERSITA DEGLI STUDI DI MILANO","The FLORA project aims to develop a comprehensive, multidimensional indicator dashboard (“FLORA dashboard”) that combines data from LiDAR, remote sensing, GIS, and human perception surveys to assess and enhance urban environments. The project seeks to address the need for a holistic tool that integrates diverse data sources to capture and score urban aesthetic perception, liveability, and health, ultimately aiding urban planners and public health officials in making data-driven decisions to impr",{"id":376,"funder":7,"programme":8,"title":377,"piName":10,"institution":378,"country":54,"year":13,"amount":14,"abstract":379},"cordis-european-research-council-award-101213421","A Chemogenetic Approach for the Treatment of Atrial Fibrillation","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","Atrial fibrillation (AF) is the most common sustained arrhythmia and is responsible for significant morbidity, mortality, and burden on the health care systems. Importantly, AF events may promote further fibrillatory episodes by inducing atrial remodelling. Traditional therapies for AF have relatively limited efficacy, and are either destructive (ablation), painful (defibrillation), or associated with side effects because of their global cardiac and systemic actions (drugs). Consequentially, nov",{"id":381,"funder":7,"programme":8,"title":382,"piName":10,"institution":383,"country":43,"year":13,"amount":14,"abstract":384},"cordis-european-research-council-award-101213895","AI-powered embryonic phenotyping for accelerated drug discovery and toxicology","UNIVERSITAT KONSTANZ","The EmbryoNet-AI project seeks to transform drug discovery and toxicology testing by integrating advanced deep learning technologies to automate phenotypic analysis of embryos and organoids. Traditional drug testing methods rely heavily on animal models, which are time-consuming, costly, and often ethically problematic. EmbryoNet-AI offers a faster, more accurate, and comprehensive solution for evaluating the effects of compounds on biological development, thus significantly enhancing the effici",{"id":386,"funder":7,"programme":8,"title":387,"piName":10,"institution":388,"country":20,"year":13,"amount":14,"abstract":389},"cordis-european-research-council-award-101213371","2d-ion crystals for quantum computing and near-term quantum applications","UNIVERSITAET INNSBRUCK","The development of a general-purpose quantum processor requires the possibility of scaling the device up to large numbers of quantum bits and the realisation of fault-tolerant quantum gate operations between them, ideally with the possibility to carry out gates between arbitrary qubit pairs. In trapped-ion based implementations, quantum gates are typically carried out on sub-ensembles of qubits that are stored in linear strings of ions. These sub-ensembles are subsequently connected by shuttling",{"id":391,"funder":7,"programme":8,"title":392,"piName":10,"institution":378,"country":54,"year":13,"amount":14,"abstract":393},"cordis-european-research-council-award-101213493","Industrial polarization imager calibration","In recent years, there has been a revolution in imaging, with a new generation of polarization-sensitive cameras entering mass markets. As we have found out in our ERC-Synergy project (CloudCT), there is a gap in calibrating such cameras. This leads to degraded imaging data in downstream applications, preventing such cameras from reaching their full potential. We will develop a system for modular calibration of such imagers, that would be fast, easy to use and reliable under harsh working condit",{"id":395,"funder":7,"programme":8,"title":396,"piName":10,"institution":324,"country":220,"year":13,"amount":14,"abstract":397},"cordis-european-research-council-award-101213068","Advanced Vortex Technology for Electrified Solvent Regeneration","The urgent need to reduce global carbon emissions is driving the development of advanced CO2 capture technologies. However, state-of-the-art packed bed-based processes (e.g., EFG+ or Linde-BASF) and rotating packed beds (CarbonClean) face significant challenges, including their high energy consumption, enormous infrastructure requirements, and operational complexities. This relates primarily to the solvent regeneration step, the Achilles' heel of absorption-based carbon capture technologies.Buil",{"id":399,"funder":7,"programme":8,"title":400,"piName":10,"institution":401,"country":70,"year":13,"amount":14,"abstract":402},"cordis-european-research-council-award-101189247","Post-Quantum Side-Channel Attack Resilience","UNIVERSITE DU LUXEMBOURG","In the rapidly evolving digital age, the advent of quantum computing poses a significant threat to current cryptographic standards, leaving sensitive information vulnerable to quantum-based attacks. This project addresses the urgent need for resilient cryptographic solutions capable of withstanding quantum threats, focusing on developing and validating post-quantum cryptographic algorithms that are resistant to side-channel attacks.Our solution involves the creation of a robust framework for eva",{"id":404,"funder":7,"programme":8,"title":405,"piName":10,"institution":406,"country":43,"year":13,"amount":14,"abstract":407},"cordis-european-research-council-award-101179931","Preventing explosions: Resolved measurement of turbulent flow electrification","PHYSIKALISCH-TECHNISCHE BUNDESANSTALT","\"Please research electrostatic charging, pleaded the R&D leader of a major chemical company. While other ignition sources for explosions can be detected, seen, or smelled, electrostatic charge appears unexpectedly whenever liquids or solids flow. Responding to the urgent need for reliable detection of electrostatic charge, we propose advancing the MefiX flow charge measurement system, a groundbreaking innovation from the ERC project PowFEct, to the proof-of-concept stage.MefiX represents a parad",{"id":409,"funder":7,"programme":8,"title":410,"piName":10,"institution":362,"country":220,"year":13,"amount":14,"abstract":411},"cordis-european-research-council-award-101213306","Valorization of Lactobacilli and their Antimicrobial Peptides for Reproductive and Intimate Health Enhancement","In an era marked by escalating concerns over antibiotic and antimycotic resistance as the next major global pandemic, the need to explore unconventional sources of antimicrobial agents has become increasingly urgent. In this context, lactobacilli, traditionally renowned for their probiotic and food applications, have recently emerged as a promising source of novel antimicrobial strategies. These lactic acid bacteria, abundant in various natural habitats including the human vagina and fermented f",{"id":413,"funder":7,"programme":8,"title":414,"piName":10,"institution":415,"country":43,"year":13,"amount":14,"abstract":416},"cordis-european-research-council-award-101213672","Diagnostic model and assay for personalized vaccine","HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH","Seasonal influenza poses a major global public health challenge, causing 3-5 million cases of severe illness and 290,000-650,000 deaths annually. Influenza vaccines are crucial for preventing illness, reducing severity of infection, and limiting virus transmission; however, their efficacy varies across populations due to factors such as immune status and pre-existing comorbidities. Immunocompromised patients (e.g. rheumatoid arthritis, HIV or organ transplant recipients) are particularly vulnera",{"id":418,"funder":7,"programme":8,"title":419,"piName":10,"institution":420,"country":421,"year":13,"amount":14,"abstract":422},"cordis-european-research-council-award-101188520","Functional cofactors for targeted modification of biomolecules","VILNIAUS UNIVERSITETAS","LT","Enzymatic addition of a methyl group (methylation) is the most prevalent natural modification in cells, serving a myriad of regulatory and structural functions. Abnormal methylation of DNA, RNA or histone proteins can lead to severe developmental defects and is associated with numerous human diseases. Selective methylation of biomolecular targets is carried out by dedicated methyltransferase enzymes, which use the cofactor S-adenosyl-L-methionine (AdoMet) as the source of methyl groups. Despite ",{"id":424,"funder":7,"programme":8,"title":425,"piName":10,"institution":426,"country":103,"year":13,"amount":14,"abstract":427},"cordis-european-research-council-award-101213190","Ultra-soft microrobots for tumour penetration","SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA","SOFTINVADERS aims at advancing the technology readiness of the microrobots prototypes developed in the ERC-funded project CELLOIDS, paving the way to their future clinical translation. In CELLOIDS, we have developed the first ultra-soft microrobots and observed that they can move through gaps narrower than their size under magnetic actuation. The microrobots have a cell-like body consisting of a Giant Unilamellar Vesicle – an aqueous liquid interior enclosed by a nanometres-thin membrane made of",{"id":429,"funder":7,"programme":8,"title":430,"piName":10,"institution":431,"country":12,"year":13,"amount":14,"abstract":432},"cordis-european-research-council-award-101213797","Targeting Type 2 Diabetes with Allene-containing Molecules Using a C-N Bond Cleavage Tool","UNIVERSIDAD AUTONOMA DE MADRID","Type 2 Diabetes is a chronic disease affecting more than 450 million people world-wide and is still an unmet medical need. PPAR´s(Peroxisome Proliferator-Activated Receptors) and G-protein-coupled receptors (GPCR) FFARs (Free Fatty Acid Receptors) are wellclinical validated targets for type-2 diabetes. Although selective GPR40 agonists have reached clinical phase III, the trials wererecently terminated due to signs of liver toxicity in patients. ALLENEDRUG is designed to provide a new chemical s",{"id":434,"funder":7,"programme":8,"title":435,"piName":10,"institution":436,"country":54,"year":13,"amount":14,"abstract":437},"cordis-european-research-council-award-101202828","Somatostatin Receptor Inhibitors for Sustaining Muscle and Bone Mass Following Pharmacologically Induced Weight Loss","THE HEBREW UNIVERSITY OF JERUSALEM","Obesity affects 1 in 6 adults in Europe, driving demand for therapy. Agonists of the Glucagon Like Peptide 1 Receptor (GLP1RAs) such as semaglutide (Novo Nordisk) and tirzepatide (Eli Lilly) have led to substantial weight loss in millions of patients. However, a large fraction of lost weight is attributed to loss of lean mass: muscle and bone. A reduction in lean mass increases the risk for sarcopenia and osteoporosis  loss of muscle and bone. Our analysis of 748,667 patients using GLP1RAs has s",{"id":439,"funder":7,"programme":8,"title":440,"piName":10,"institution":441,"country":81,"year":13,"amount":14,"abstract":442},"cordis-european-research-council-award-101189411","Overcoming limits for pre-clinical  small volume liquid delivery into skin and inflammation quantification","UNIVERSITEIT TWENTE","Chronic inflammatory skin diseases have a huge burden on patients, their families, and the economy. New patient-friendly delivery methods are urgently needed targeting immune cells in the dermis. Injecting small volumes of biologics directly in skin lesions using needle-free technology would revolutionize treatments and shift the systemic dosing paradigm to individualized local dosing.However, to realize this vision, there is a long path to test its effectiveness in pre-clinical (in vitro, ex vi",{"id":444,"funder":7,"programme":8,"title":445,"piName":10,"institution":362,"country":220,"year":13,"amount":14,"abstract":446},"cordis-european-research-council-award-101212832","The initial stream of a urine void.","The ability to easily obtain appropriate and reliable biological samples is critical to advancing life sciences and public\u002Fpersonal health. Having a sample that is non-invasive and can be self-collected at home has major acceptance and implementation advantages. Our team has already demonstrated that first-void urine (FVU) samples can replace clinician-collected cervical samples in Human Papillomavirus (HPV) based cervical cancer screening. Using the initial or first-void urine stream is crucial",{"id":448,"funder":7,"programme":8,"title":449,"piName":10,"institution":450,"country":54,"year":13,"amount":14,"abstract":451},"cordis-european-research-council-award-101212631","RNA Epithelial Approach for Crohn’s Treatment","MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER","RE-ACT aims to translate groundbreaking ERC-funded research on lncRNA-based therapy for Crohn's Disease (CD) into a commercially viable treatment option. Our innovative approach targets the gut epithelial lining using lncRNA encapsulated in lipid nanoparticles (LNPs), addressing a critical gap in current CD treatments which primarily focus on immune suppression. By restoring epithelial function, we aim to achieve better mucosal healing and long-term patient outcomes. Building on our discovery of",{"id":453,"funder":7,"programme":8,"title":454,"piName":10,"institution":455,"country":43,"year":13,"amount":14,"abstract":456},"cordis-european-research-council-award-101213765","Innate Lymphoid Cell Engagers (ILCEs): Targeting Innate Lymphoid Cells through a Bispecific Engager for the Resolution of Chronic Inflammation","UNIVERSITATSKLINIKUM ERLANGEN","Chronic inflammatory diseases, such as rheumatoid arthritis (RA) and spondyloarthropathies (SpA) represent a persistent healthcare challenge, requiring life-long management because of treatments with limited long-term efficacy. The key to a breakthrough may lie in the strategic engagement of Innate Lymphoid Cells (ILCs), whose potential in resolving inflammation and reprogramming tissue memory emerges from the recent ERC-funded research by Rauber et al. (2024). The study published in Nature Immu",{"id":458,"funder":7,"programme":8,"title":459,"piName":10,"institution":86,"country":54,"year":13,"amount":14,"abstract":460},"cordis-european-research-council-award-101197927","Cryogenic nanoscale metrology of quantum circuits","Quantum computing holds the potential to highly impact our society and revolutionize scientific research, healthcare, finance, and beyond. As the complexity of quantum circuits increases, advanced tools for nanoscale metrology of the sources of decoherence and energy loss will become vital for large scale fabrication, inspection, and optimization of quantum devices and microcircuits. The main obstacle is that in contrast to classical computation, solid state quantum devices operate at sub-Kelvin",{"id":462,"funder":7,"programme":8,"title":463,"piName":10,"institution":86,"country":54,"year":13,"amount":14,"abstract":464},"cordis-european-research-council-award-101212874","RNA Fusion-Inducing Antisense Oligonucleotides as a Treatment for Wiedemann-Steiner Syndrome","There is an immense interest in RNA therapeutics for a wide variety of health conditions. Neurodevelopmental disorders (NDDs), which mostly have no available treatments or cures, affect millions of children and adults across Europe, and are estimated to account for as much as 1-3% of the total EU healthcare expenditure. Wiedemann-Steiner Syndrome (WSS) is an NDD that currently has no available treatment and is not amenable to traditional gene therapy approaches. Antisense oligonucleotides (ASOs)",{"id":466,"funder":7,"programme":8,"title":467,"piName":10,"institution":468,"country":43,"year":13,"amount":14,"abstract":469},"cordis-european-research-council-award-101212569","Thermodynamically Robust Transfer Reagents for Molecular Editing","GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS","The increasing demand of complex organic molecules, either because of their biological activity or technical interest are opening a new period in Organic Synthesis, which is mainly focused on the discovery of novel transformations that can be carried out in already (poly)functionalized substrates. As part of this trend, the development new reagents capable to transfer additional functional groups at the desired position of advanced synthetic intermediates is of paramount importance. Areas such a",{"id":471,"funder":7,"programme":8,"title":472,"piName":10,"institution":86,"country":54,"year":13,"amount":14,"abstract":473},"cordis-european-research-council-award-101212592","Zonal Guided Liver Testing for liver disease diagnosis and stratification","Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is emerging as the leading chronic liver disease worldwide. Identifying MASLD patients that are at higher risk of rapid progression is an outstanding challenge, but it would enable focusing resources on the patients with high risk while saving un-necessary costly liver function tests and biopsies for the majority of patients. MASLD progression is influenced by the liver's spatial heterogeneity, where variable gene expression along ",{"id":475,"funder":7,"programme":8,"title":476,"piName":10,"institution":477,"country":12,"year":13,"amount":14,"abstract":478},"cordis-european-research-council-award-101213638","Bispecific bi-paratopic antibodies for the treatment of cancer","ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS","Immune checkpoint inhibitors have revolutionized cancer therapy, yet the majority of patients do not respond to current treatments, such as PD-1\u002FPD-L1blockade. In non-small cell lung cancer (NSCLC), over 70% of patients experience immune evasion mechanisms that prevent effective immune activation. One such mechanism involves the overexpression of glycans on tumor cells, which can modulate immune responses. In this project, we propose to develop novel bispecific bi-paratopic antibodies that simul",{"id":480,"funder":7,"programme":8,"title":481,"piName":10,"institution":482,"country":92,"year":13,"amount":14,"abstract":483},"cordis-european-research-council-award-101213389","Carboxylic acids as REAcTIVE refrigerants to make heat pumps efficient","UNIVERSITE DE LORRAINE","Aiming to contribute to a substantial increase in the sustainability of thermal power plants, heat pumps, and climatization systems, the ERC-StG-REACHER is introducing new working fluids for the thermodynamic cycle underlying these systems. These new fluids are mixtures of dimers “A2” and monomers “A” undergoing a reversible dimerization reaction, A2 ⇄ 2 A, evolving instantaneously and spontaneously in the unit operations of the machine. REACHER has introduced about 200 of these reactive fluids.",{"id":485,"funder":7,"programme":8,"title":486,"piName":10,"institution":340,"country":26,"year":13,"amount":14,"abstract":487},"cordis-european-research-council-award-101213674","Revolutionising peptide-based drug discovery with high-throughput mimotope mapping","Peptide-based drugs offer distinct advantages over existing molecular therapeutics, such as their ability to engage targets that have proven challenging for small molecules, and their capability to penetrate cells and modulate intracellular targets, which conventional biologics cannot achieve. However, despite this potential, the development of peptide-based medicines has lagged due to the lack of high-quality, large-scale protein-peptide interaction datasets essential for rational AI-driven pep",{"id":489,"funder":7,"programme":8,"title":490,"piName":10,"institution":491,"country":103,"year":13,"amount":14,"abstract":492},"cordis-european-research-council-award-101212872","PhOtonics QUantum Bernoulli Factory","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","A Bernoulli factory is a randomness manipulation routine that takes as input a Bernoulli random variable and provides as output another Bernoulli variable whose bias is a function of the input bias. Recently proposed Quantum-to-Quantum Bernoulli Factory schemes encode both input and output variables in qubit amplitudes. This primitive could be used as a key ingredient for quantum networking at the interface of quantum computing and cryptography, as well as a subroutine for more complex quantum a",{"id":494,"funder":7,"programme":8,"title":495,"piName":10,"institution":496,"country":305,"year":13,"amount":14,"abstract":497},"cordis-european-research-council-award-101212629","Precise, Rapid and Scalable Proteomics Solutions for Archaeology, Ecology, Wildlife Forensics and Food-chain Authentication","NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU","Taxonomic identification of tiny organic samples using proteins (proteomics) has major, but only partially realised, potential in archaeology, ecology, wildlife forensics and food-chain authentication. It is a cost-effective and minimally destructive alternative to DNA analysis that can be applied even when DNA is not preserved. However, the most widespread method, known as ‘zooarchaeology by mass spectrometry’ (ZooMS) or peptide mass fingerprinting, cannot differentiate some taxa of major histo",{"id":499,"funder":7,"programme":8,"title":500,"piName":10,"institution":340,"country":26,"year":13,"amount":14,"abstract":501},"cordis-european-research-council-award-101247546","Metabolically Enhanced Lactic Acid Bacteria for Boosting Cancer Therapy","Inter-individual variation in cancer therapy responses is significant, with a substantial fraction of patients not responding to treatment. This exposes non-responders to harmful side effects without benefit and results in vast resources being spent on eventually ineffective treatments. A key factor behind this variability is differences in microbiome composition and metabolism. However, translating microbiome-cancer research into live bacterial therapies that modulate the microbiome is challeng",{"id":503,"funder":7,"programme":8,"title":504,"piName":10,"institution":505,"country":506,"year":13,"amount":14,"abstract":507},"cordis-european-research-council-award-101247549","From evolutionary biology to crop mushrooms: constructing sporeless mushroom strains","HUN-REN SZEGEDI BIOLOGIAI KUTATOKOZPONT","HU","In our previous ERC project we identified a broad panel of fungal genes that are associated with spore formation, one of the largest problems in industry-scale crop mushroom production. The mushroom market intensely seeks sporeless strains, however, existing ones are used by a small fraction of growers, because, in addition to sporelessness, they show unwanted morphological defects, which reduce crop quality. In preliminary experiments, we demonstrated that CRISPR-based targeting of novel genes ",{"id":509,"funder":7,"programme":8,"title":510,"piName":10,"institution":86,"country":54,"year":13,"amount":14,"abstract":511},"cordis-european-research-council-award-101247244","Exudation Agriculture: Highly Efficient and Continued Production of Carminic Acid Pigment for the Natural Colorants Industry","Natural pigments are gaining importance in the EU as safer and more sustainable alternatives to synthetic colorants, but their use also presents challenges which have been hindering their wide adoption in the colorants market, particularly in terms of scalability, cost, and ethical sourcing. Carminic acid is widely used as a natural alternative and exemplifies these production challenges: it requires a labour-intensive extraction process, has negative ethical and environmental impacts for insect",{"id":513,"funder":7,"programme":8,"title":514,"piName":10,"institution":441,"country":81,"year":13,"amount":14,"abstract":515},"cordis-european-research-council-award-101213654","Robotic and Electrical Stimulation Platform for Integral Neuromuscular Enhancement","RE-SPINE develops a real-time neuro-robotic platform for lower limb rehabilitation. Motor recovery following neuromuscular injuries is often sub-optimal. A key barrier hampering progress is that current neurorehabilitation robots interact with the human with limited knowledge of their effect on critical neuromuscular targets.RE-SPINE addresses this challenge by proposing a platform that integrates a stationary robotic ankle exoskeleton with a non-invasive spinal cord electrical stimulation syste",{"id":517,"funder":7,"programme":8,"title":518,"piName":10,"institution":519,"country":520,"year":13,"amount":14,"abstract":521},"cordis-european-research-council-award-101212799","A Digitally-Enabled Electroconductive Patient-Specific Stimulation Implant for Spinal Cord Injury","ROYAL COLLEGE OF SURGEONS IN IRELAND","IE","Spinal cord injury (SCI) can severely impact patients, impairing neurological function. The complex pathophysiology of SCI and the poor growth capacity of neurons results in a multi-faceted challenge to repair. Lifetime treatment costs for SCI patients can be as high as €2 million and approximately 11,000 new spinal cord injuries occur every year in the EU. Neuromodulation devices that provide controlled electrical stimuli to enable pain management, aid rehabilitation and represent a growing med",{"id":523,"funder":7,"programme":8,"title":524,"piName":10,"institution":525,"country":81,"year":13,"amount":14,"abstract":526},"cordis-european-research-council-award-101213384","Realizing ambulatory shock-free termination of atrial fibrillation","ACADEMISCH ZIEKENHUIS LEIDEN","Atrial fibrillation (AF) is the most common type of heart rhythm disturbance, progressive in nature and associated with high morbidity and mortality. Thus, an effective and broadly applicable treatment to quickly restore normal rhythm at any time and place is highly desired. However, such therapy is lacking. In contrast to drugs and ablation, electrical cardioversion of AF is effective in broad populations of AF patients, but can only performed within hospitals because of the required patient se",{"id":528,"funder":7,"programme":8,"title":529,"piName":10,"institution":143,"country":43,"year":13,"amount":14,"abstract":530},"cordis-european-research-council-award-101202143","GlycoRoads: A platform for the de novo design of glycans","In the spirit of the various in silico de novo protein design products, GlycoRoads aims to introduce the world's first tool for de novo glycan design. Our cutting-edge screening platform will harness the power of molecular dynamics (MD) simulations to analyse hundreds of thousands of glycan structures, extracting crucial structural information to populate a comprehensive database (DB). This rich repository of data will serve as the foundation for an AI-driven user interface, designed to interrog",{"id":532,"funder":7,"programme":8,"title":533,"piName":10,"institution":534,"country":20,"year":13,"amount":14,"abstract":535},"cordis-european-research-council-award-101199020","A high performance cost-effective MINFLUX microscope","UNIVERSITAT WIEN","MINFLUX is a novel super-resolution microscopy technology that localizes single fluorophores with extraordinary precision and enables structural imaging and single particle tracking with unprecedented spatiotemporal resolution. It can monitor conformational changes of proteins in living cells, which has the potential to revolutionize dynamic structural biology. Current MINFLUX microscopes however are complex and difficult to build, and the only commercial instrument is costly and has reduced fun",{"id":537,"funder":7,"programme":8,"title":538,"piName":10,"institution":340,"country":26,"year":13,"amount":14,"abstract":539},"cordis-european-research-council-award-101189467","PeptInsure:  Using Peptides to ensure, assure and Insure protein authenticity and quality","Food fraud and mislabeling undermine public trust in the food industry and regulatory bodies. The scale of these issues is heightened by the so-called Protein Gap. PeptInsure offers a new solution to authentication of protein in the food and feed industries by leveraging the strengths of ZooMS for peptide mass fingerprinting (PMF) and the novel LAP-MALDI technology, enhancing the specificity, affordability, and efficacy of protein analysis. This unique combination, alongside advanced software to",{"id":541,"funder":7,"programme":8,"title":542,"piName":10,"institution":543,"country":26,"year":13,"amount":14,"abstract":544},"cordis-european-research-council-award-101189457","Scaling up iPSC Expansion and Differentiation using Recombinant Bioemulsions","QUEEN MARY UNIVERSITY OF LONDON","Advances in stem cell technologies have revolutionised cell therapy and advanced in vitro models, but remain limited by our ability to scale up and automate cell manufacturing. In particular, induced pluripotent stem cell (iPSC) expansion and differentiation require complex processing protocols that are preventing the wider deployment of associated technologies to the clinic and industry. Although solid and hydrogel microcarriers have displayed potential in addressing this challenge, they presen",{"id":546,"funder":7,"programme":8,"title":547,"piName":10,"institution":548,"country":32,"year":13,"amount":14,"abstract":549},"cordis-european-research-council-award-101248721","Assembly of large synthetic genomes using nanofluidics","CHALMERS TEKNISKA HOGSKOLA AB","Synthetic genomics is a rapidly growing branch of synthetic biology where the goal is to assemble a complete genome from small synthetic DNA fragments. The main obstacle is the later stages of assembly where fragments on the kilobasepair length scale are to be assembled, where the efficiency rapidly falls off with increasing fragment size. A large contribution to this bottleneck is purely physical, where the probability of DNA ends meeting decreases with increasing DNA size. My solution to this ",{"id":551,"funder":7,"programme":8,"title":552,"piName":10,"institution":553,"country":12,"year":13,"amount":14,"abstract":554},"cordis-european-research-council-award-101213167","deepHelix: a massively scalable, AI-powered peptide drug discovery platform","FUNDACIO CENTRE DE REGULACIO GENOMICA","Peptide drugs potentially address limitations of both small molecules and antibodies. Small molecules struggle to target protein-protein interactions (PPIs), while antibodies cannot access intracellular proteins.  In this project we will develop an AI-driven experimental platform to produce cell-permeable therapeutic peptides made entirely of natural amino acids. The platform will allow the rapid discovery of cost-effective, stable, cell-permeable, and high-affinity peptide binders for use as re",{"id":556,"funder":7,"programme":8,"title":557,"piName":10,"institution":196,"country":81,"year":13,"amount":14,"abstract":558},"cordis-european-research-council-award-101212624","Virus-Inspired modular Assembly for cargo loading in Extracellular Vesicles-Inspired CArdiac REpair","The fundamental objective of the VIA-EVICARE ERC Proof of Concept project is to ascertain the technical and commercial feasibility of a ground-breaking technology to revolutionize the delivery of therapeutics via extracellular vesicles (EVs). EVs are naturally occurring nanosized vesicles that facilitate the transfer of biological cargo between cells and offer numerous benefits over conventional drug delivery systems. By leveraging a novel, virus-inspired mechanism, we aim for a modular design t",{"id":560,"funder":7,"programme":8,"title":561,"piName":10,"institution":25,"country":26,"year":13,"amount":14,"abstract":562},"cordis-european-research-council-award-101188956","Exploring the Applications of Picodroplet Mass Spectrometry","Mass spectrometry (MS) is a widely applied analytical tool underpinning important commercial sectors like biotechnology, pharmaceutics, and environmental analysis. A significant drawback is that the analysis is destructive, resulting in irretrievable sample loss and making MS nonideal when sample is expensive or scarce. We pioneered a technology capable of reducing the amount of sample consumed during MS by >4000 times compared to the existing state-of-the-art by using picolitre (10^-12 L) dropl",{"id":564,"funder":7,"programme":8,"title":565,"piName":10,"institution":566,"country":20,"year":13,"amount":14,"abstract":567},"cordis-european-research-council-award-101213411","LEARN: Learning Efficient Automated Reasoning on the Net","TECHNISCHE UNIVERSITAET WIEN","Certified computer systems are becoming the key in the increasingly complex decision making activities of our modern society. Among others, provably correct\u002Fsecure solutions within Artificial Intelligence (AI), Autonomous Systems, Big Data, Blockchain, Decentralized Finance (DeFi), Cloud Computing, or Machine Learning (ML) are indispensable in the  ongoing digitalization of our society. While the explosion in applications of computer systems leads to great increases in productivity, wealth, and ",{"id":569,"funder":7,"programme":8,"title":570,"piName":10,"institution":239,"country":103,"year":13,"amount":14,"abstract":571},"cordis-european-research-council-award-101213265","MicroScale system integrating Patient-specific cancer Organoids in a 3D Tumor microenvironment for Therapy rEsponse preDiction","Cancer remains a leading global cause of death, with incidence projected to increase significantly by 2050. Despite advances in detection and treatment, there is an urgent need for more effective and personalized therapies. Personalized medicine (PM) is emerging as the future of cancer care, using 3D patient-specific models to replicate the tumors complexity. Current in vitro models struggle to accurately mimic the tumor microenvironment (TME), including the extracellular matrix (ECM) and stroma",{"id":573,"funder":7,"programme":8,"title":574,"piName":10,"institution":152,"country":32,"year":13,"amount":14,"abstract":575},"cordis-european-research-council-award-101248724","Cellular immunoTHERapy modelling by exploitation of humanized OSSicles","Bones represent a privileged site for cancer initiation and metastasis. Yet, current in vitro and animal models fall short in accurately recapitulating bone-developing cancers. To address this, we developed the human ossicle (hOss) technology: the in vivo formation of miniaturized bone organs composed of patient-derived bone and marrow cells. By mimicking the patient’s bone microenvironment, hOss offer a personalized model for studying bone-related cancers. To ensure reproducibility and standard",{"id":577,"funder":7,"programme":8,"title":578,"piName":10,"institution":579,"country":81,"year":13,"amount":14,"abstract":580},"cordis-european-research-council-award-101213120","Using senolytic agents to suppress the toxicity of chemotherapy","STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS","Many of the clinically used cancer chemotherapies have considerable short-term side effects, including fatigue, bone marrow suppression, nausea, diarrhea, and hair loss. Long-term side effects include cognitive impairment, organ dysfunction, and even secondary cancers. A body of evidence indicates that senescent cells induced by chemotherapy in non-cancerous tissues play a major part in these toxicities of chemotherapy. As part of the SENCAN grant, we have developed a cocktail of two drugs that ",{"id":582,"funder":7,"programme":8,"title":583,"piName":10,"institution":584,"country":585,"year":13,"amount":14,"abstract":586},"cordis-european-research-council-award-101248226","A Fibroblast-Targeting Advanced Lead Mitigating Inflammation and Fibrosis in IBD","INOLYSIS MONOPROSOPI IDIOTIKI KEFALAIOUCHIKI ETAIREIA","EL","Inflammatory bowel disease (IBD), which comprises Crohn's disease (CD) and ulcerative colitis (UC), is a growing global health challenge affecting over 6.8 million people. Characterized by chronic inflammation leading to intestinal fibrosis, IBD significantly reduces quality of life and increases the risk of severe complications, including colon cancer. Current treatments primarily target inflammation, and fail to address the persistent activation of inflammatory fibroblast phenotypes and the re",{"id":588,"funder":7,"programme":8,"title":589,"piName":10,"institution":590,"country":43,"year":13,"amount":14,"abstract":591},"cordis-european-research-council-award-101248030","Thermal Magnetic Resonance-based Ablation Cancer Therapy","MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)","The MR-ACT project will develop Thermal Magnetic Resonance-based Ablation Cancer Therapy, a groundbreaking non-invasive approach that eliminates the need for invasive needle electrodes or fibre optic Laser probes in cancer ablation procedures. Building upon innovations from our ERC Advanced Grant ThermalMR, we will advance our proprietary high-density radiofrequency (RF) applicator technology to achieve ablative temperatures (>60°C) for tumour tissue destruction while maintaining millimetre-prec",{"id":593,"funder":7,"programme":8,"title":594,"piName":10,"institution":324,"country":220,"year":13,"amount":14,"abstract":595},"cordis-european-research-council-award-101248306","Hybrid Encapsulated Advanced Thermometers for CAncer Mapping and thERApy","Early cancer diagnosis gives best chance for successful treatment. However, the currently available imaging techniques (CT, MRI, ultrasound) are limited in detecting very small cancerous lesions. Also, the location of the tumor may play a role in how big it must grow before it is visible. This is resulting in a rising interest from the medical community in new diagnostic tools. Luminescent thermometers could be an excellent new approach for early cancer detection. However, diagnosis alone is not",{"id":597,"funder":7,"programme":8,"title":598,"piName":10,"institution":121,"country":122,"year":13,"amount":14,"abstract":599},"cordis-european-research-council-award-101248549","Implementation of acoustic lens technology for Super-resolution Ultrasound Real-time microvascular  Imaging using Erythrocytes - iSURElens","The iSURELens Proof-of-Concept project will develop an ultrasound imaging system capable of visualizing the micro-vasculature of the entire human kidney in a clinical environment. Such ultrasound images are highly desired for providing early diagnosis of diseases such as cancer and diabetes using a non-invasive and cost-effective imaging modality. The proposed imaging system comprises a probe, lens and beamformer based on the methods developed in the SURE ERC synergy grant project for Super-reso",{"id":601,"funder":7,"programme":8,"title":602,"piName":10,"institution":603,"country":54,"year":13,"amount":14,"abstract":604},"cordis-european-research-council-award-101248654","Multiomic DNA Chip Technology for Blood Cancer Profiling","TEL AVIV UNIVERSITY","Blood cancers remain challenging to diagnose and monitor due to the standard of care requirement for bone marrow biopsies and limitations in current biomarker detection technologies. DNA modifications, specifically 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)—are powerful epigenetic regulators in blood cancer development, providing valuable diagnostic and prognostic information. Despite their clinical importance, current technologies fail to simultaneously detect both 5mC and 5hmC w",{"id":606,"funder":7,"programme":8,"title":607,"piName":10,"institution":64,"country":43,"year":13,"amount":14,"abstract":608},"cordis-european-research-council-award-101213420","Virus-Inspired Colorectal Cancer Treatment through an Orally Administered Vaccine","Colorectal cancer (CRC), which includes cancers of the colon and rectum, represents a significant global health challenge as the third most commonly diagnosed and second most fatal cancer worldwide. It also places a substantial burden on European patients and healthcare systems. While standard treatments are available, they face significant limitations, especially in managing advanced CRC, often leading to poor patient outcomes and severely compromised quality of life. Emerging immunotherapies l",{"id":610,"funder":7,"programme":8,"title":611,"piName":10,"institution":612,"country":43,"year":13,"amount":14,"abstract":613},"cordis-european-research-council-award-101247327","Tailored technologies for the development of next-generation PROTAC molecules (DEGRON)","CHRISTIAN-ALBRECHTS-UNIVERSITAET  ZU KIEL","PROTACs (Proteolysis-Targeting Chimeras) are a groundbreaking class of novel therapeutics capable of targeting disease-causing proteins previously thought to be undruggable. They work by recruiting E3 ligases to ubiquitinate target proteins, leading to their degradation. However, despite their promise, current PROTAC design is severely limited, relying on only two out of 613 E3 ligases. In addition, PROTAC development remains slow, inefficient and heavily reliant on trial-and-error approaches.Th",{"id":615,"funder":7,"programme":8,"title":616,"piName":10,"institution":617,"country":26,"year":13,"amount":14,"abstract":618},"cordis-european-research-council-award-101247739","FLUOROgenic probes for rapid assessment of immunoTheRAPies in precision oncology","THE UNIVERSITY OF EDINBURGH","Cancer is the second-leading cause of death globally with more than 10 million deaths worldwide in 2020. Immunotherapies can reactivate the immune system against tumors and are promising treatments for many types of cancer; however, only a small fraction of patients that receive immunotherapies show positive responses and it remains unclear what therapy is most suitable for every patient. There is a clear need for rapid, simple and functional assays that can rapidly evaluate the efficacy of anti",{"id":620,"funder":7,"programme":8,"title":621,"piName":10,"institution":622,"country":220,"year":13,"amount":14,"abstract":623},"cordis-european-research-council-award-101248564","Positive allosteric modulators of the PD-1•PD-L1 interaction as a new mode of therapeutic intervention for autoimmune diseases: preclinical proof of concept in humanized mice","VIB VZW","The immune system's balance in fighting infections or cancer while avoiding autoimmune reactions is regulated by co-inhibitory and co-stimulatory immune checkpoints (ICs). ICs are major drug targets in immunotherapy, with antibodies (Abs) blocking inhibitory ICs to fight cancer, and Abs blocking stimulatory ICs in clinical trials for autoimmune diseases.Surprisingly, but likely fuelled by the worldwide focus on IC inhibitors, the field largely ignored that ICs are genuine transmembrane receptors",{"id":625,"funder":7,"programme":8,"title":626,"piName":10,"institution":627,"country":103,"year":13,"amount":14,"abstract":628},"cordis-european-research-council-award-101212894","HYPERspectral monitoring for accurate light-based SKIN cancer treatment","POLITECNICO DI MILANO","The increasing incidence of non-melanoma skin cancer (NMSC, 330,000 new cases in Europe, 2022), due to the increase of elderly population, unprotected sun exposure and still poor prevention, is a huge public health concern worldwide. Recurrences and consequent need for repeated surgery are mainly associated with incomplete excision and positive tumor margins. Also, typical surgical risks of poor scarring, infection, pain, and time-consuming histopathological analysis demand innovative approaches",{"id":630,"funder":7,"programme":8,"title":631,"piName":10,"institution":632,"country":12,"year":13,"amount":14,"abstract":633},"cordis-european-research-council-award-101247187","Bringing MYC inhibition to the brain by ultrasound technology","FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO)","Brain tumours and brain metastases pose a significant therapeutic challenge due to limited treatment options, fatally linked to high morbidity and mortality. Treatment of these cancers is hindered by the presence of the blood-brain barrier (BBB), that restricts the free passage of molecules larger than 400 daltons, reducing the effectiveness of therapeutically impermeable compounds. While deregulation of the MYC oncogene is a main feature of these cancers, to date, effective and clinically-viabl",{"id":635,"funder":7,"programme":8,"title":636,"piName":10,"institution":637,"country":12,"year":13,"amount":14,"abstract":638},"cordis-european-research-council-award-101213556","INhibiting mechanoTRansduction as a novel approach for Oncology theraPY (INTROPY)","FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA","Increased tissue stiffness is a hallmark of many solid tumours, driving tumour progression. This occurs through mechanotransduction, the process by which cells sense and respond to mechanical signals. Our lab has identified a key interaction between two proteins, essential for mechanotransduction. This interaction is triggered by force-induced unfolding of a target protein, which occurs only in stiff tissues. Hence, we propose a novel therapeutic approach that targets mechanotransduction by inhi",{"id":640,"funder":7,"programme":8,"title":641,"piName":10,"institution":143,"country":43,"year":13,"amount":14,"abstract":642},"cordis-european-research-council-award-101213404","PathsToDormancy: Identifying dormancy pathways for selective targeting","The survival and propagation of species fundamentally depend on the precise regulation of cellular growth and dormancy. This balance is crucial across various biological processes including reproduction, regeneration, and repair, where mechanisms such as embryonic diapause allow organisms to endure adverse conditions by temporarily halting development. During this dormant state, embryonic cells undergo significant rewiring of their transcriptional, epigenetic, and metabolic pathways, preserving ",{"id":644,"funder":7,"programme":8,"title":645,"piName":10,"institution":637,"country":12,"year":13,"amount":14,"abstract":646},"cordis-european-research-council-award-101248631","An evolution-focused platform for cancer drug discovery","Solid tumours frequently develop resistance to therapies, leading to treatment failure. This resistance arises from the complex interplay between heterogeneous cancer cell populations and their microenvironment, driving tumour evolution and local adaptation. Current drug discovery pipelines fall short in addressing this complexity. In this ERC-PoC, we will develop EVOaware, a groundbreaking platform that integrates genome editing, spatial barcoding, high-throughput drug screening, multimodal spa",{"id":648,"funder":7,"programme":8,"title":649,"piName":10,"institution":650,"country":12,"year":13,"amount":14,"abstract":651},"cordis-european-research-council-award-101202409","Targeting intracelular RANKL in breast cancer","FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III","Breast cancer is the most common malignancy among females in the western world, resulting in half a million deaths annually, mainly due to metastatic disease. Triple negative breast cancer (TNBC) accounts for 1520% of all breast cancers (300.000 women diagnosed worldwide per year). Despite novel treatments, TNBC remains a clinical challenge due to high rate of relapse, a propensity to form visceral metastasis and its heterogeneity. There is an urgent need to identify novel targeted therapies and",{"id":653,"funder":7,"programme":8,"title":654,"piName":10,"institution":553,"country":12,"year":13,"amount":14,"abstract":655},"cordis-european-research-council-award-101187456","Simple and cost-effective cancer diagnosis in liquid biopsy through native tRNA sequencing","Transfer RNAs (tRNAs) are abundant, heavily-modified small non-coding RNAs that play a pivotal role in decoding genetic information, determining which transcripts are highly and poorly translated at a given moment. Dysregulation of tRNA abundances and tRNA modifications is a well-known feature in cancer cells, leading to enhanced translation of specific oncogenic proteins. Despite the well-established association between tRNA dysregulation and cancer progression and malignancy, tRNA abundances a",{"id":657,"funder":7,"programme":8,"title":658,"piName":10,"institution":294,"country":32,"year":13,"amount":14,"abstract":659},"cordis-european-research-council-award-101247966","Cost-effective and Sensitive DNA Methylation Profiling for Advancing Single-Cell Epigenomics","Epigenetic dysregulation is a key contributor to numerous major diseases, including cancer, neurodegenerative disorders, and autoimmune conditions, underscoring the critical need for scalable and cost-effective profiling technologies. A central challenge in precision medicine is the heterogeneity in patient responses to treatment, which is influenced by inter-individual epigenetic variability. DNA methylation, a fundamental epigenetic modification, plays a central role in disease pathogenesis an",{"id":661,"funder":7,"programme":8,"title":662,"piName":10,"institution":637,"country":12,"year":13,"amount":14,"abstract":663},"cordis-european-research-council-award-101248403","Functional bioinks for engineered tissues","Bioinks are materials that hold cells during bioprinting. They perform key functions, including protecting cells from high shear stress during the printing process but also, and importantly, provide the extracellular environment for cells after printing. Bioinks must be made of biocompatible materials that in addition should provide the functional environment needed for cells to perform their functions. This is critical as bioprinting underpins developments of in vitro tissue models to advance b",{"id":665,"funder":7,"programme":8,"title":666,"piName":10,"institution":80,"country":81,"year":13,"amount":14,"abstract":667},"cordis-european-research-council-award-101247911","Pioneering Self-Encoded Library Strategies for DNA\u002FRNA Binding Proteins","The ExSELence project aims to validate and commercialize an innovative drug discovery platform that addresses key limitations in current screening technologies. Traditional approaches to identifying drug candidates, such as DNA-encoded libraries, face significant constraints when screening certain protein targets, particularly those involved in DNA and RNA processing. Our platform eliminates these constraints through a novel barcode-free approach that combines advanced synthesis methods with sop",{"id":669,"funder":7,"programme":8,"title":670,"piName":10,"institution":324,"country":220,"year":13,"amount":14,"abstract":671},"cordis-european-research-council-award-101212937","Colonial Legacies and Redress: A Digital Mapping Solution for Europe","Colonialism is often seen as a chapter in history, yet its consequences – interwoven with structural racism and discrimination – continue to affect societies both inside and outside of Europe today. A growing number of institutional and civil society actors recognize the urgency of addressing these enduring legacies. Their efforts encompass policy, legal, and political reforms, historical truth-seeking processes, formal apologies, reparations, restitution of looted artifacts, memorialization, an",{"id":673,"funder":7,"programme":8,"title":674,"piName":10,"institution":675,"country":43,"year":13,"amount":14,"abstract":676},"cordis-european-research-council-award-101189497","Development of a nanobody-based, slide-free approach for 3D-Histological analysis of the spatial tumor microenvironment using lightsheet imaging","CHARITE - UNIVERSITAETSMEDIZIN BERLIN","For histopathological analysis and subsequent diagnosis of diseased tissues a rapid, accurate histopathological and genetic analysis of biopsied tissues are essential. However, traditional 2-dimensional slide-based histopathological analysis does not represent spatial tissue structures and molecular targets sufficiently, which aggravates an accurate and spatial analysis of tissue, a detailed description of the tumor microenvironment as well as patient stratification.         To overcome these li",{"id":678,"funder":7,"programme":8,"title":679,"piName":10,"institution":675,"country":43,"year":13,"amount":14,"abstract":680},"cordis-european-research-council-award-101188709","Paving the way for off-the-shelf adoptive Treg therapy using epigenetic forward programming","Regulatory T cells (Treg) are a type of immune cell that can suppress harmful inflammation caused by autoimmune diseases or organ transplant rejection. Using Treg as a living drug is a promising form of precision medicine, but it faces many practical and economic challenges, such as the need to produce a specific cell product for each patient. A more feasible solution would be to create off-the-shelf Treg products that are readily available and can be used universally without customizing them fo",{"id":682,"funder":7,"programme":8,"title":683,"piName":10,"institution":675,"country":43,"year":13,"amount":14,"abstract":684},"cordis-european-research-council-award-101185344","Precision Diagnostics for Predicting Therapy Response to Bispecific Antibodies","Immunotherapies have revolutionized cancer treatment by utilizing the patient's immune system, offering hope for treating a wide range of diseases. However, challenges such as therapy resistance, poor response rates, and high costs remain. Precision diagnostics that accurately identify patients likely to benefit from specific immunotherapies could optimize treatment efficacy, reduce unnecessary treatments, and significantly decrease healthcare expenses. A major limitation of current predictive b",{"id":686,"funder":7,"programme":8,"title":687,"piName":10,"institution":143,"country":43,"year":13,"amount":14,"abstract":688},"cordis-european-research-council-award-101213353","Automated Image Analysis for High-Throughput Single Molecule Analysis of Biomolecules","Project Virgil aims to revolutionize single-molecule analysis by developing automated, high-throughput image-to-structure software for scanning probe microscopy (SPM) images. This innovative technology addresses a critical bottleneck in biomolecular research: the low data throughput and time-consuming manual interpretation of SPM images. Building on recent breakthroughs in direct SPM imaging of single biomolecules, Project Virgil aims to create a parallel-computing program to interpret SPM image",{"id":690,"funder":7,"programme":8,"title":691,"piName":10,"institution":219,"country":220,"year":13,"amount":14,"abstract":692},"cordis-european-research-council-award-101213646","Integrated photonics-based structured illumination for sequencing","High-throughput next-generation sequencing has revolutionized healthcare. Nevertheless, widespread adoption remains hindered by a trade-off between clinically relevant turnaround times and cost-effectiveness. This trade-off arises from the limitations of sequencing-by-synthesis (SBS) chemistry and traditional optical readout architectures. To address this, integrated parallel readout on a CMOS imager is the preferred technology – as opposed to free space microscope scanners. However, size and nu",{"id":694,"funder":7,"programme":8,"title":695,"piName":10,"institution":436,"country":54,"year":13,"amount":14,"abstract":696},"cordis-european-research-council-award-101212789","Automated High-throughput Behavioral Measurement in Co-Housed Mice for Safer and More Effective Psychiatric Drug Development","Drug development for psychiatric and neurological disorders requires extensive preclinical testing for validation of safety and efficacy. Preclinical investigation of Central Nervous System (CNS) - acting drugs is primarily performed using traditional lab assays in rodent models. These experiments are typically based on manual analysis of isolated subjects, requiring huge investment in lab animals and technicians for brief measurements. These preclinical experiments are consequently subject to m",{"id":698,"funder":7,"programme":8,"title":699,"piName":10,"institution":436,"country":54,"year":13,"amount":14,"abstract":700},"cordis-european-research-council-award-101213113","Dual-Layer Coatings for Iron and Steel Corrosion Protection","Corrosion undermines metal integrity, resulting in significant environmental and economic damage (exceeding $ 2.5 trillion). The anti-corrosion coating market was $ 34.8B in 2022, however, anti-corrosive coatings have three limitations: (1) High costs (2) Toxicity (3) Limited effectiveness. During my ERC project we developed and patented a technology that uses a dual-layer coating, engineered at the molecular level to provide a highly stable coating on iron to mitigate corrosion formation. The s",{"id":702,"funder":7,"programme":8,"title":703,"piName":10,"institution":704,"country":705,"year":13,"amount":14,"abstract":706},"cordis-european-research-council-award-101212589","Optimizing music-based rehabilitation for post-stroke aphasia","HELSINGIN YLIOPISTO","FI","Aphasia causes severe impairments in verbal communication, coupled with cognitive and motor deficits and depression, making it the most debilitating and socioeconomically burdening consequence of stroke. As our population ages and prevalence of stroke and associated care costs increase, persons with aphasia (PWA) often do not receive sufficient rehabilitation in public health care. Effective remote rehabilitation applications are urgently needed to ensure comprehensive and cost-effective aphasia",{"id":708,"funder":7,"programme":8,"title":709,"piName":10,"institution":704,"country":705,"year":13,"amount":14,"abstract":710},"cordis-european-research-council-award-101189399","Wood-Derived Hybrid Particles for Stabilized Dispersions","Aqueous particle dispersions are elemental to many aspects of every-day life, from food and pharmaceuticals to construction materials. However, todays dispersion science faces a grand challenge in developing colloidal particles with outstanding functionality in a sustainable manner. To enable societys transformation from oil-based economy to bioeconomy, there is an urgent need to develop sophisticated biocompatible materials, such as particle dispersions, from biomass-derived precursors through ",{"id":712,"funder":7,"programme":8,"title":713,"piName":10,"institution":704,"country":705,"year":13,"amount":14,"abstract":714},"cordis-european-research-council-award-101213555","Multilingual Assets and Resources for Modular Translation","Recent innovations in language technologies have introduced large language models that industry players often pitch as one-size-fit-all solutions. These systems are however rarely reusable in novel contexts, nor sustainable given their massive parameter counts, nor scalable across the thousands of languages spoken in the world. In response, we intend to build upon the findings of ERC funded project FoTran, and develop modular architectures in which parts of a network are designed to be specializ",{"id":716,"funder":7,"programme":8,"title":717,"piName":10,"institution":718,"country":26,"year":13,"amount":14,"abstract":719},"cordis-european-research-council-award-101247309","Morphomolecular diagnostics of head and neck cancer","KING'S COLLEGE LONDON","Head and neck cancers (HNC) represent a significant global health burden and have poor survival rates when diagnosed at advanced stages. Early detection at precancerous or early cancer stages is the most effective strategy to reduce mortality, improve patient outcomes and save healthcare expenses. However, current endoscopic approaches are limited in their ability to provide accurate diagnosis, monitoring and timely intervention.     Building upon patented ERC research, the LEAN project addresse",{"id":721,"funder":7,"programme":8,"title":722,"piName":10,"institution":723,"country":81,"year":13,"amount":14,"abstract":724},"cordis-european-research-council-award-101207558","A cheap, fast and reliable diagnostic test for Tuberculosis Infection","RIJKSUNIVERSITEIT GRONINGEN","Latent tuberculosis infection (TBI) occurs when someone is infected with Mycobacterium tuberculosis but does not have active TB disease. Those with TBI are at risk of developing active TB, with 8–10% progressing without antibiotic treatment, causing significant societal and economic impacts. Testing higher-risk groups, including immunocompromised individuals (e.g., those on immunosuppressive therapy, HIV-positive), close contacts with active TB cases, healthcare workers, and people from high TB ",{"id":726,"funder":7,"programme":8,"title":727,"piName":10,"institution":728,"country":32,"year":13,"amount":14,"abstract":729},"cordis-european-research-council-award-101213016","Food quality control by RNA profiling (foodRNA)","STOCKHOLMS UNIVERSITET","The field of food quality control is important to all consumers - ensuring food safety and detecting food substitutions and fraud. Next-generation sequencing has the potential to revolutionize the field, but practical solutions are lagging behind. State-of-the-art DNA-based tests yield limited information beyond what animal, plant and bacterial species constitute a given food product - and in some cases performing that task sub-optimally. Profiling RNA in food products can potentially yield impo",{"id":731,"funder":7,"programme":8,"title":732,"piName":10,"institution":733,"country":26,"year":13,"amount":14,"abstract":734},"cordis-european-research-council-award-101188662","Transcranial photobiomodulation for motion sickness mitigation","UNIVERSITY OF GLASGOW","Cyber- and motion sickness are debilitating for many people, limiting both travel opportunities, and the use of new technologies such as virtual and augmented reality. These forms of sickness are due to nauseogenic sensory mismatch (NSM). Cybersickness affects up to 50% of people use who AR and VR headsets. Motion sickness affects 30% of travellers in all forms of transport, with even more getting sick if they use AR or VR as a passenger. To mitigate the effects of NSM, the PhotoMod project will",{"id":736,"funder":7,"programme":8,"title":737,"piName":10,"institution":738,"country":739,"year":13,"amount":14,"abstract":740},"cordis-european-research-council-award-101213428","Textile-Based Soft Robotics for Virtual Reality Applications","ISTANBUL TEKNIK UNIVERSITESI","TR","In this ERC Proof of Concept project, we aim to advance the development of a wearable soft robotic device, named TexSoRVA, designed for haptic feedback and motion tracking. This device will feature seamlessly integrated sensing, actuation, and self-powering capabilities, all achieved through innovative digital machine-knitting techniques. Our primary demonstration will be a soft robotic haptic glove intended for virtual reality (VR) applications.TexSoRVA builds upon the foundational technology d",{"id":742,"funder":7,"programme":8,"title":743,"piName":10,"institution":744,"country":12,"year":13,"amount":14,"abstract":745},"cordis-european-research-council-award-101189447","Heterogeneous Integrated Short-wave Infrared Colloidal Quantum Dot Lasers","FUNDACIO INSTITUT DE CIENCIES FOTONIQUES","IRQUAL addresses the critical need for compact, integrated lasers operating in the short-wave infrared (SWIR) spectrum (1.3  2.5 m) for diverse applications such as consumer electronics, automotive, IoT, and AR\u002FVR. Specifically, lasers in the eye-safe window (around 1.4 m and > 2 m) are crucial for LIDAR systems, 3D face recognition, and environmental monitoring. Current technologies, including solid-state lasers and III-V semiconductor laser diodes, face limitations in size, cost, performance a",{"id":747,"funder":7,"programme":8,"title":748,"piName":10,"institution":749,"country":43,"year":13,"amount":14,"abstract":750},"cordis-european-research-council-award-101189511","Bayesian Experimental Design for in situ (Scanning) Transmission Electron Microscopy – BED-TEM","TECHNISCHE UNIVERSITAT DARMSTADT","The proposed project, Bayesian Experimental Design for in situ (Scanning) Transmission Electron Microscopy (BED-TEM), addresses challenges in conducting in situ (S)TEM experiments, particularly in selecting optimal stimuli parameters. While recent advancements in microelectromechanical systems (MEMS) have expanded stimulus options, determining appropriate values remains elusive, often relying on time-consuming trial and error. The project aims to introduce a software platform integrating Bayesia",{"id":752,"funder":7,"programme":8,"title":753,"piName":10,"institution":754,"country":26,"year":13,"amount":14,"abstract":755},"cordis-european-research-council-award-101212775","Privacy-Preserving Human MObility Trajectory Data GeneratOr","UNIVERSITY COLLEGE LONDON","People travel and leave their location history as mobility trajectory data. This data is invaluable for a wide range of location-based services, including city planning, traffic control, disease transmission and optimal control, trade area analysis, location-based marketing, and tourism, consequently leading to the rise of new business models. Recognising these opportunities, governments and industries have increasingly invested in exploring data-driven solutions. However, data challenges persis",{"id":757,"funder":7,"programme":8,"title":758,"piName":10,"institution":31,"country":32,"year":13,"amount":14,"abstract":759},"cordis-european-research-council-award-101248707","Diagnosing skewed X-inactivation in women - Tandem Repeat-based Identification of X-chromosome Inactivation (TRiXi)","Disease-causing mutations on the X-chromosome (‘X-linked’ disorders) typically only affect men. However, due to a genetic phenomenon called skewed X-inactivation (sXCI), thousands of girls and women in Europe also develop serious and often life-threatening X-linked disorders every year. As there is no reliable test for sXCI in humans, women carrying mutations are typically unaware of their risk, and when symptoms do develop, diagnosis is delayed. We have developed a method for quick, cheap and a",{"id":761,"funder":7,"programme":8,"title":762,"piName":10,"institution":86,"country":54,"year":13,"amount":14,"abstract":763},"cordis-european-research-council-award-101243581","Enhancing TCR-T cell therapy by combinatorial therapeutic approaches to target neoantigen-positive cancers","Non-small-cell-lung-cancer (NSCLC) remains one of the most lethal cancers (≈1.5 million deaths annually), and current treatments fail to achieve universal, lasting remissions. While immune checkpoint therapies have improved NSCLC outcomes, many patients either do not respond or relapse, underscoring an urgent need for new, more effective strategies. NeoCure directly addresses this need by harnessing T-cell receptor (TCR) engineering to target tumor-specific neoantigens. In our prior research (ER",{"id":765,"funder":7,"programme":8,"title":766,"piName":10,"institution":143,"country":43,"year":13,"amount":14,"abstract":767},"cordis-european-research-council-award-101248503","Exploiting Transcriptional Adaptation to Develop New Genetic Compensation-based Therapies","Organisms display various mechanisms to compensate for the deleterious effects of harmful mutations.  One such mechanism is transcriptional adaptation (TA), a recently identified mode of gene regulation whereby mutant mRNA decay triggers the transcriptional modulation of so-called adapting genes, independently of protein loss (Rossi et al., Nature 2015; El-Brolosy et al., Nature 2019).  In some cases, TA can lead to functional compensation by upregulating genes that are functionally redundant wi",{"id":769,"funder":7,"programme":8,"title":770,"piName":10,"institution":53,"country":54,"year":13,"amount":14,"abstract":771},"cordis-european-research-council-award-101203100","Male Paediatric Fertility Restoration using Testis Organoids","Chemotherapy treatments for cancer and haematological disorders can lead to male infertility. While adult males can freeze a sperm biopsy prior to chemotherapy, pre-pubertal children cannot do so, as they do not yet produce sperm. Reaching 88% survival rate for paediatric cancers nowadays, many of these kids will survive to adulthood but remain infertile. There are currently no clinical fertilityrestoration options available for these kids. Many of them are advised to undergo a testis biopsy pro",{"id":773,"funder":7,"programme":8,"title":774,"piName":10,"institution":775,"country":103,"year":13,"amount":14,"abstract":776},"cordis-european-research-council-award-101189458","PREDICT: PRoviding Effective longitudinal models of RAS DIrect inhibition to Combat Tumor resistance","UNIVERSITA DEGLI STUDI DI TORINO","Problem:In 2022, more than half a million lung cancer patients worldwide carrying KRAS mutations faced therapy resistance, a trend on the rise. Such cancers resist standard treatments and targeted therapies, leading to an average survival of 1.2 years post-treatment. The heterogeneous genetic background of KRAS-driven cancer adds further complexity, hindering personalized treatment due to resistance unpredictability.Solution:Our Proof Of Concept (PoC) project PREDICT provides a personalized trea",{"id":778,"funder":7,"programme":8,"title":779,"piName":10,"institution":196,"country":81,"year":13,"amount":14,"abstract":780},"cordis-european-research-council-award-101189464","IMPlementation of Affordable gene Correction Therapies","Rare genetic diseases affect over 30 million people in Europe. Although individually rare and very diverse, they are all caused by genetic mutations. Recent progress in genetic technologies now holds the promise to correct the root cause of these diseases. However, it remains difficult to develop these innovative technologies into affordable therapies for these diseases that only affect few patients, limiting commercial interest.IMPACT aims to overcome the translational gap between scientific ge",{"id":782,"funder":7,"programme":8,"title":783,"piName":10,"institution":784,"country":43,"year":13,"amount":14,"abstract":785},"cordis-european-research-council-award-101248577","Exploiting Therapy-Induced Neo-Epitopes to Overcome Drug Resistance in Triple-Negative Breast Cancer","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","Therapy-induced neo-antigens represent a novel class of tumor-specific antigens that arise from therapeutic interventions such as chemotherapy and targeted therapies. These neo-antigens, resulting from genomic mutations, aberrant post-translational modifications, and dysregulated RNA splicing, are recognized by the immune system as foreign, prompting an immune response that bypasses central tolerance mechanisms. Despite advancements in next-generation sequencing and bioinformatics that facilitat",{"id":787,"funder":7,"programme":8,"title":788,"piName":10,"institution":340,"country":26,"year":13,"amount":14,"abstract":789},"cordis-european-research-council-award-101189134","Scale-up and Demonstrator of Luminescent Waveguide Encoded Films for Indoor Photovoltaics","The Internet of Things (IoT) underpins our future smart world where various electronic devices could be integrated with, and controlled by, wireless communication. Many of these devices will be standalone or portable, creating an urgent demand for off-grid power sources. Solar photovoltaic (PV) cells are viable alternatives to batteries as perpetual power sources for IoT devices. However, crystalline silicon (c-Si) PV cells (which account for 95% of the global PV market) are not designed to work",{"id":791,"funder":7,"programme":8,"title":792,"piName":10,"institution":793,"country":43,"year":13,"amount":14,"abstract":794},"cordis-european-research-council-award-101248542","Compact plug-and-play quantum network terminals based on deterministic semiconductor sources","GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER","Communications networks have brought incredible convenience to our lives, making it possible for billions of people to connect and communicate at the touch of a button. However, despite their ease of use, these networks remain vulnerable to security threats, with frequent cyber-attacks and the growing danger of quantum computing underscoring the need for stronger protections. Quantum communication offers a potential solution against these security threats. Research institutions worldwide are mak",{"id":796,"funder":7,"programme":8,"title":797,"piName":10,"institution":798,"country":81,"year":13,"amount":14,"abstract":799},"cordis-european-research-council-award-101213439","AAV9-tRNA-Gly: Towards a first effective therapy for Charcot-Marie-Tooth peripheral neuropathy","STICHTING RADBOUD UNIVERSITEIT","Charcot-Marie-Tooth (CMT) disease is the most common inherited neuromuscular disease, characterized by selective degeneration of peripheral motor and sensory neurons, leading to progressive muscle weakness and wasting, and sensory dysfunction. Currently, no effective, FDA\u002FEMA-approved therapies are available for CMT, necessitating life-long symptomatic treatment. We recently identified the molecular mechanism underlying CMT caused by mutations in glycyl-tRNA synthetase (GlyRS). We showed that tr",{"id":801,"funder":7,"programme":8,"title":802,"piName":10,"institution":803,"country":12,"year":13,"amount":14,"abstract":804},"cordis-european-research-council-award-101213941","Self-Supported Electrodes via Roll-to-Roll Manufacturing Using Non-Critical Materials for GrEen Hydrogen Production","UNIVERSITAT DE VALENCIA","Hydrogen is expected to be essential in achieving EU objectives to reduce greenhouse gas emissions. However, while water electrolysis (WE) efficiency can be comparable to fossil fuels, hydrogen produced by WE via renewable or low-carbon energy (green hydrogen) only accounts for 4% of the global hydrogen supply, mainly due to the still-high costs and lower performance of current electrolysers, as a result of the sluggish kinetics and the high overpotentials needed for the oxygen evolution reactio",{"id":806,"funder":7,"programme":8,"title":807,"piName":10,"institution":808,"country":26,"year":13,"amount":14,"abstract":809},"cordis-european-research-council-award-101213590","Developing a scalable production route for functional high performance in-situ TEM cells","THE UNIVERSITY OF MANCHESTER","This project aims to revolutionize in-situ gas cell transmission electron microscopy (TEM) by scaling up the novel in-situ cells that have been pioneered in the EvoluTEM Starting grant. Traditional commercially available gas cells limit TEM imaging resolution and spectroscopy due to significant electron scattering. The EvoluTEM project has demonstrated a proof of principle cell design which reduces the electron scattering and hence provides opportunities for TEM experiments with greatly improved",{"id":811,"funder":7,"programme":8,"title":812,"piName":10,"institution":723,"country":81,"year":13,"amount":14,"abstract":813},"cordis-european-research-council-award-101213611","A Leap in Ligand Technology: The Development and Valorization of Novel Chiral Diphosphine Ligands","The search for innovative and efficient chiral catalysts and ligands for producing enantiopure molecules remains a vital priority across the pharmaceutical, flavours and fragrances, and agrochemical sectors. A significant majority of newly developed drugs are chiral, creating an increasing demand for advancements in asymmetric synthesis and the development of chiral ligands and metal complexes, which is driving substantial progress in asymmetric catalysis. Despite these advances, the number of c",{"id":815,"funder":7,"programme":8,"title":816,"piName":10,"institution":340,"country":26,"year":13,"amount":14,"abstract":817},"cordis-european-research-council-award-101213277","High Throughput Modelling and Measurement of Human Epithelial Models using Electrospun Conducting Polymers For Unlocking Data-Driven Drug Discovery","Organ on Chip (OoC) technology, which models human tissues in vitro, is poised to refactor the drug discovery pipeline and alleviate the financial burden with the added benefit of reducing\u002F refining animal experimentation. The advent of non-destructive, biosensing modalities has placed data-driven approaches to identifying new therapeutics within reach, where highly parallelized instances of human organ models can be mined for AI and ML-augmented discovery. During our ERC CoG grant, we developed",{"id":819,"funder":7,"programme":8,"title":820,"piName":10,"institution":821,"country":43,"year":13,"amount":14,"abstract":822},"cordis-european-research-council-award-101213032","Ring laser gyroscopes for ground motion sensing","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","Sensors for rotation are ubiquitous in our daily life, ranging from consumer electronics to navigation systems. Applications that require highest sensitivity for very small rotation rates rely on active ring laser gyroscopes (RLGs) or fiber-optic gyroscopes (FOGs). These devices, however, suffer from intrinsic bias drift and do not reach the sensitivity requirements of applications such as seismology and monitoring of ground motion.Out of the parent ERC project on optical precision measurements ",{"id":824,"funder":7,"programme":8,"title":825,"piName":10,"institution":19,"country":20,"year":13,"amount":14,"abstract":826},"cordis-european-research-council-award-101212942","Food Responsive Sensor for Colorimetric Observation","Enhancing food safety and reducing waste are global challenges, especially with the rise in food consumption and distribution. Food spoilage is a key component of these challenges. One of the critical indicators of food spoilage is the presence of toxic compounds formed by microbial activity in protein-rich foods such as fish, meat, and cheese.The FRESCO project develops an innovative colorimetric sensor for detecting toxic by-products. This sensor utilizes advanced porous materials that change ",{"id":828,"funder":7,"programme":8,"title":829,"piName":10,"institution":830,"country":831,"year":13,"amount":14,"abstract":832},"cordis-european-research-council-award-101213664","WaterSAFE: An Integrated Cyber-Physical Security Solution for Water Distribution Systems","UNIVERSITY OF CYPRUS","CY","The WaterSAFE project addresses the growing threat of malicious attacks on water distribution Cyber-Physical Systems (CPS)—an unprecedented risk to public health, safety, and critical infrastructure operations. While the integration of Information Technology with Operational Technology in water organizations has revolutionized the evolution of smart water systems, it has also exposed security vulnerabilities.WaterSAFE introduces a groundbreaking CPS security-as-a-service solution for water distr",{"id":834,"funder":7,"programme":8,"title":835,"piName":10,"institution":836,"country":12,"year":13,"amount":14,"abstract":837},"cordis-european-research-council-award-101247700","Intelligent BIo-inspired flapping-wing aerial Robots for noise and air quality Data Sampling in environment conservation","GINATEC SOLUTIONS","I-BIRDS proposes the development of the first intelligent system capable of generating high-resolution 3D maps of noise and air quality in urban and industrial environments using bio-inspired flapping-wing robots. This system will significantly reduce the cost of manual sampling for noise and pollutant levels, as well as the deployment and maintenance of static sensor networks.Flapping-wing Unmanned Aerial Vehicles (UAVs), also known as ornithopters, offer key advantages over conventional propel",{"id":839,"funder":7,"programme":8,"title":840,"piName":10,"institution":436,"country":54,"year":13,"amount":14,"abstract":841},"cordis-european-research-council-award-101189519","Enhancing Synchrony in Autism: Introducing the MirrorPods-Intervention Platform","Autism, a neurodevelopmental disorder affecting millions globally, severely impacts the quality of life of individuals diagnosed with this lifelong condition, and that of their families. It imposes an immense financial burden on health and educational systems, projected to grow alongside increasing diagnosis and prevalence rates. The magnitude of this crisis calls for more effective therapies that incorporate a nuanced, contemporary understanding of autism. Recent research and therapies point to",{"id":843,"funder":7,"programme":8,"title":844,"piName":10,"institution":284,"country":26,"year":13,"amount":14,"abstract":845},"cordis-european-research-council-award-101188366","Hazard sensors based on holographic metasurfaces for near eye augmented reality displays","Augmented reality (AR) technology is uniquely positioned in the tech landscape, offering the ability to overlay digital information directly onto the physical world, distinct from virtual reality (VR) and mixed reality (MR). Existing and next-generation AR glasses are sophisticated and expensive and are far from meeting the needs of large sections of the general population. For example, despite the advancements in AR, a significant gap exists in catering to users with partial visual or auditory ",{"id":847,"funder":7,"programme":8,"title":848,"piName":10,"institution":378,"country":54,"year":13,"amount":14,"abstract":849},"cordis-european-research-council-award-101246161","Fluidic Lens Maker - disruptive approach to ophthalmic manufacturing","In this PoC we propose to develop the Fluidic Lens Maker - a device which will enable rapid, wasteless, and automated end-to-end fabrication of ophthalmic lenses (i.e. vision correction eyeglasses), without relying on complex and expensive infrastructure or elaborate supply chains. The Fluidic Lens Maker will be based on a technology that we have developed as part of our ERC project ‘Fluidic Shaping’, which allows to shape curable liquids into high-quality optics by utilizing the surface tension",{"id":851,"funder":7,"programme":8,"title":852,"piName":10,"institution":853,"country":32,"year":13,"amount":14,"abstract":854},"cordis-european-research-council-award-101212879","MiniTweezer: Optical Tweezers with Automation and Artificial Intelligence","GOETEBORGS UNIVERSITET","Optical tweezers have revolutionized various scientific disciplines, especially single-molecule research and single-cell mechanobiology. For example, they have played a fundamental role in understanding the folding dynamics and mechanical properties of DNA. In 2018, recognizing their importance, Arthur Ashkin was awarded a share of the Nobel Prize in Physics for the invention of optical tweezers and their application to biological systems.However, even though their broad range of applications at",{"id":856,"funder":7,"programme":8,"title":857,"piName":10,"institution":858,"country":859,"year":13,"amount":14,"abstract":860},"cordis-european-research-council-award-101213902","Conciliating a ‘Bearable Life’. Participatory Action Research on Entangled Cross-Border Mobilities","INSTITUTO DE CIENCIAS SOCIAIS","PT","Despite their high hopes and aspirations, people crossing borders in search of a ‘better life’ are frequently led to reassess and pare down their ambitions and expectations, and to realign them towards what this project conceptualises as a ‘bearable life’. This is a key finding of the ERC StG on which the present PoC builds. To put the notion of ‘bearable life’ to the test, explore its value, and operationalize its social innovation potential, the PoC develops a ground-breaking applied anthropol",{"id":862,"funder":7,"programme":8,"title":863,"piName":10,"institution":864,"country":103,"year":13,"amount":14,"abstract":865},"cordis-european-research-council-award-101189347","Flexible Lead-free Perovskite Solar Cells Implementation in Photovoltaic Shading Systems","UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II","One of the key measures being undertaken by the EU to tackle climate change and reduce CO2 emissions is to massively increase the amount of energy produced from renewable sources, particularly solar energy. In this context, perovskite solar cells represent a low- cost technological solution of great interest because they open to new possible photovoltaic (PV) applications. However, the most effective PV perovskites contain more than 10% by weight of lead, which oversteps the limits adopted in mo",{"id":867,"funder":7,"programme":8,"title":868,"piName":10,"institution":274,"country":103,"year":13,"amount":14,"abstract":869},"cordis-european-research-council-award-101212751","Variable Stiffness Upper Limb Prosthesis","Losing a limb can profoundly impact a person's physical, emotional, and social well-being. While current upper limb prostheses restore users' basic motor capabilities, they fall short of replicating the natural appearance and functionality of a human limb. The innate compliance and controllable stiffness of the human musculoskeletal system allow individuals to adapt seamlessly to various tasks and environments. Intuitively, prostheses with user-controllable stiffness could mimic this behaviour, ",{"id":871,"funder":7,"programme":8,"title":872,"piName":10,"institution":254,"country":220,"year":13,"amount":14,"abstract":873},"cordis-european-research-council-award-101246272","Advanced conversion of sulphate salts in circular hydrometallurgy","The EU aims to achieve climate neutrality with net-zero greenhouse gas emissions by 2050, necessitating the electrification of key sectors like mobility and energy. Lithium-ion batteries (LIBs) are crucial for this transition. To enhance strategic autonomy amid global competition and an increasingly hostile geopolitical context, the EU targets more strategic autonomy along the entire mine-to battery supply chain. This implies minimum targets for domestic extraction (10%), processing (40%) and re",{"id":875,"funder":7,"programme":8,"title":876,"piName":10,"institution":877,"country":12,"year":13,"amount":14,"abstract":878},"cordis-european-research-council-award-101213311","Three-phase Redox Flow Battery","Fundacion IMDEA Energia","The high cost and poor performance of certain components of redox flow batteries (RFB) such as the ion-exchange membrane, along with material toxicity, fluctuating prices, and limited availability of vanadium active compounds, are hindering the widespread adoption of RFB in the market. Our 3-Phase-BAT ERC-PoC involves the development of a new type of membrane-free RFB which does not require the use of any membrane since the electrolytes are separated by thermodynamics eliminating the requirement",{"id":880,"funder":7,"programme":8,"title":881,"piName":10,"institution":808,"country":26,"year":13,"amount":14,"abstract":882},"cordis-european-research-council-award-101212610","A Ruthenium Master Precatalyst with High Stability and Versatility","Catalysts play a crucial role in the chemical industry, with the production of approximately 90% of all chemicals dependant on catalysts at some stage in the manufacturing process. Ruthenium catalysis holds great potential in synthetic chemistry, offering unique capabilities in catalysing reactions like olefin metathesis and asymmetric hydrogenation. However, the field is hindered by the lack of versatile and stable ‘master precatalysts’, capable of allowing the reliable fast generation and scre",{"id":884,"funder":7,"programme":8,"title":885,"piName":10,"institution":744,"country":12,"year":13,"amount":14,"abstract":886},"cordis-european-research-council-award-101213596","scaling sustainable Anodes for efficIent water ElectroLysis","ARIEL (scaling sustainable Anodes for efficIent water ElectroLysis) seeks to demonstrate and validate a scalable process for the synthesis, activation, and implementation of non-platinum-group catalysts for water electrolysis  a bottleneck on the path to the projected gigawatt deployment of this technology that is needed to meet carbon emission targets. We have previously demonstrated, at the lab-scale, the feasibility and potential of cobalt-based anodes as alternative to iridium in proton-exch",{"id":888,"funder":7,"programme":8,"title":889,"piName":10,"institution":102,"country":103,"year":13,"amount":14,"abstract":890},"cordis-european-research-council-award-101213390","SERS-based Technology for EarLy Liquid biopsy Analysis and Recognition","STELLAR introduces a groundbreaking approach to early cancer detection, leveraging surface-enhanced Raman spectroscopy (SERS) and artificial intelligence (AI) to analyse microRNAs (miRNAs) in liquid biopsies. This innovative technology aims to revolutionize cancer screening by offering a non-invasive, cost-effective, and highly accurate method for identifying cancer-specific miRNA biomarkers. STELLAR's core innovation lies in its ability to detect and discriminate between normal and mutated miRN",{"id":892,"funder":7,"programme":8,"title":893,"piName":10,"institution":894,"country":220,"year":13,"amount":14,"abstract":895},"cordis-european-research-council-award-101213347","Reversing metabolic reprogramming in obesity-associated hepatocellular carcinoma by inhibiting receptor protein tyrosine phosphatases","UNIVERSITE LIBRE DE BRUXELLES","REPRO-PTP is addressing the critical need for effective treatments in obesity-associated hepatocellular carcinoma (HCC). HCC, which accounts for 90% of primary liver cancers, is refractory to conventional chemotherapy with very low survival rate. As obesity is a major risk factor for HCC, it is imperative to develop new therapeutic approaches. My laboratory has identified receptor protein tyrosine phosphatases (PTPs) as key regulators of glycolysis and lipogenesis, with PTPRK emerging as a parti",{"id":897,"funder":7,"programme":8,"title":898,"piName":10,"institution":899,"country":43,"year":13,"amount":14,"abstract":900},"cordis-european-research-council-award-101248609","Sulfite export mechanisms as a therapeutic vulnerability in KEAP1-deficient lung cancer","JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG","Non-small cell lung cancer (NSCLC) harboring KEAP1 mutations is associated with a poor prognosis and resistance to conventional therapies. However, KEAP1\u002FNRF2 dysregulation induces metabolic reprogramming, which can be exploited for therapeutic benefit. Our research has uncovered that these cells produce and accumulate high levels of sulfur-containing compounds, a metabolic vulnerability in these cancer cells. To maintain cellular homeostasis and survival, these cells rely on the active export o",{"id":902,"funder":7,"programme":8,"title":903,"piName":10,"institution":904,"country":905,"year":13,"amount":14,"abstract":906},"cordis-european-research-council-award-101248749","Democratizing access to Quantum limited microwave parametric AMPlifiers","ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE","CH","Amplifiers are essential in science and technology – they are needed to overcome the detection threshold of sensors, like antennas, detectors or even our ears. When a signal is weak or generated at a distance, amplification becomes necessary. However, amplification adds noise, and if noise exceeds the signal, detection becomes impossible or needs heavy post-processing, limiting applications that rely on weak signals or high sensitivity. Over the last century, amplifiers have evolved to reduce no",{"id":908,"funder":7,"programme":8,"title":909,"piName":10,"institution":910,"country":859,"year":13,"amount":14,"abstract":911},"cordis-european-research-council-award-101248711","A Framework for Auditing Recommendation Engines under the DSA","LABORATORIO DE INSTRUMENTACAO E FISICA EXPERIMENTAL DE PARTICULAS LIP","This proposal presents a novel pipeline framework designed to systematically audit Search Engines (SEs) and chat-based Large Language Models (LLMs), serving as a proof-of-concept tool to support the implementation of Article 40 of the EU's Digital Services Act (DSA). The project addresses two critical goals: 1) to investigate how proprietary algorithms in SEs and LLMs influence electoral processes, and 2) to provide practical guidance to overcome complex DSA implementation challenges.SEs, such a",{"id":913,"funder":7,"programme":8,"title":914,"piName":10,"institution":915,"country":859,"year":13,"amount":14,"abstract":916},"cordis-european-research-council-award-101213647","Bio-Engineered Dyeing Innovations for Sustainable Cotton Textiles","UNIVERSIDADE NOVA DE LISBOA","The environmental and societal impact of fabric dyeing is a critical concern, with the textile industry ranking among the most chemically intensive and the second-largest polluter of clean water globally. Traditional dyeing methods consume large amounts of water and energy, release toxic chemicals, and contribute significantly to environmental degradation. Thus, there is an urgent need for sustainable dyeing innovations that reduce chemical usage and conserve water. In this ERC PoC, we aim to de",{"id":918,"funder":7,"programme":8,"title":919,"piName":10,"institution":915,"country":859,"year":13,"amount":14,"abstract":920},"cordis-european-research-council-award-101188579","Novel small molecule attenuator of neuroinflammation in Parkinson’s Disease","Parkinson’s disease (PD) affects 8.5 million individuals worldwide according to WHO estimates. PD remains cureless and treatments are based on administration of dopamine precursors or analogues. Neuroinflammation is a central hallmark of PD, however, no molecule is present in the market to tackle neuroinflammation in PD patients. Neuroinflammation contributes to the exacerbation of the disease, as the release of inflammatory signals leads to reduced neuronal fitness driving to neuronal death. NE",{"id":922,"funder":7,"programme":8,"title":923,"piName":10,"institution":64,"country":43,"year":13,"amount":14,"abstract":924},"cordis-european-research-council-award-101212974","Disrupting the myofibroblast cell cycle to treat Kidney Fibrosis with a novel small molecule compound inhibitor (DISRUPT-KF)","Chronic kidney disease (CKD) is a progressive disease in which kidney function is gradually lost. It can develop consequent of many (kidney) diseases and it affects more than 10% of the world population. Although in recent years sodium–glucose cotransporter 2 inhibitors and novel non-steroidal mineralocorticoid antagonists are showing significant effects on CKD, the majority of patients treated still progress towards end-stage renal disease (ESRD). With dialysis or kidney transplantation as the ",{"id":926,"funder":7,"programme":8,"title":927,"piName":10,"institution":928,"country":103,"year":13,"amount":14,"abstract":929},"cordis-european-research-council-award-101213566","Universal Cardiac Mesoangioblasts for treating  DMD Dilated Cardiomyopathy","OSPEDALE SAN RAFFAELE SRL","Dilated cardiomyopathy (DCM) is the second most common cause of heart failure, currently treated with drugs that delay progress towards heart transplantation. There are currently many attempts to treat DC with stem cells or their extracellular vesicles or AAV vectors: none reached efficacy so far. The applicant has a long track record in cell and gene therapy for muscular dystrophy. He pioneered systemic intra-arterial transplantation of mesoangioblasts (blood vessel-derived progenitors) and, th",{"id":931,"funder":7,"programme":8,"title":932,"piName":10,"institution":244,"country":92,"year":13,"amount":14,"abstract":933},"cordis-european-research-council-award-101188820","Preventing rejection and ensuring survival of grafts","The success of organ transplantation depends on the lifelong use of immunosuppressive drugs to prevent rejection of the donor cells by the recipients immune system. These immunosuppressive drugs have several limitations, most notably major side effects, namely opportunistic infections and cancers. We have recently shown that the bacterial pathogen Listeria monocytogenes (Lm) induces the resistance of infected cells to T-cell mediated killing. This project aims to protect grafted cells from T cel",{"id":935,"funder":7,"programme":8,"title":936,"piName":10,"institution":450,"country":54,"year":13,"amount":14,"abstract":937},"cordis-european-research-council-award-101212591","Developing RNA-editing based therapy for renal cystic ciliopathies","Chronic Kidney Disease (CKD) is a significant global health burden, affecting approximately 10% of the adult population worldwide. It is estimated that 10-20% of advanced CKD cases are caused by genetic kidney diseases, with renal cystic ciliopathies being the most common genetic contributors. In the Israeli Druze population, we have identified a novel homozygous mutation in the WDR19 gene as the leading cause of end-stage kidney disease (ESKD), particularly leading to renal failure in young adu",{"id":939,"funder":7,"programme":8,"title":940,"piName":10,"institution":627,"country":103,"year":13,"amount":14,"abstract":941},"cordis-european-research-council-award-101188904","A Multi-fidelity Approach Enabling Automated High Precision in Cold Spray Repair","The EU's manufacturing sector is facing a crucial challenge to achieve ambitious sustainability goals in the transition towards a circular economy. While repair and remanufacturing are key solutions to this issue, current techniques fall short due to limitations in handling complex (geometry and material-wise) parts, heat damage and a lack of automation. This results in a staggering amount of waste – over 167 million tons generated annually by the EU manufacturing industry alone. CoRe offers a s",{"id":943,"funder":7,"programme":8,"title":944,"piName":10,"institution":42,"country":43,"year":13,"amount":14,"abstract":945},"cordis-european-research-council-award-101213058","Hydrogel Coatings for Improving the Efficiency of Implanted Electrode Arrays","Implanted electrode arrays are a key component of neuroprosthetic systems designed to restore functions lost through injury or degeneration of the nervous system. Electrode arrays currently used in clinical practice are made from metals (e.g., Platinum, PtIr alloys) encapsulated in silicone. These materials strike a compromise between electrical properties on one side and good tissue integration on the other. For example, the limited charge injection capacity and high mechanical stiffens of meta",{"id":947,"funder":7,"programme":8,"title":948,"piName":10,"institution":534,"country":20,"year":13,"amount":14,"abstract":949},"cordis-european-research-council-award-101212909","Theranostic Peptide Tracers for Breast Cancer","Breast cancer impacts one in eight women globally, resulting in over half a million deaths each year. Current diagnostic methods fall short, with ~40% of breast cancers having already spread at the time of diagnosis and mammography often producing high rates of false positives. Additionally, there is a lack of reliable tools for monitoring treatment responses, tracking recurrences, or providing real-time tumour visualisation to aid surgical tumour removal.This project addresses these challenges ",{"id":951,"funder":7,"programme":8,"title":952,"piName":10,"institution":953,"country":81,"year":13,"amount":14,"abstract":954},"cordis-european-research-council-award-101248607","A Sustainable Biocatalytic Alternative for Paracetamol Production","TECHNISCHE UNIVERSITEIT DELFT","Current paracetamol production relies on century-old chemical methods that have significant environmental drawbacks, including high energy consumption, low process efficiency, and substantial waste generation. The BioParacetamol solution offers a more sustainable alternative by using enzymes to catalyse reactions at lower temperatures, producing fewer toxic by-products.This innovative process utilises a simplified one-pot, two-step synthesis, reducing energy demands, increasing efficiency, and m",{"id":956,"funder":7,"programme":8,"title":957,"piName":10,"institution":958,"country":520,"year":13,"amount":14,"abstract":959},"cordis-european-research-council-award-101189390","3rdAI Playlist Generator","UNIVERSITY COLLEGE CORK -  NATIONAL UNIVERSITY OF IRELAND, CORK","3rdAI is the worlds first research-grade Playlist Generatora tool that combines the granular detail of user-defined searches across our specialist-curated, semantically-tagged 450,000+ track lyrical corpus with the machine learning features of our hip hop-savvy AI.  Over the course of our cultural data analytics research on the ERC project, CIPHER: Hip Hop Interpellation (globalcipher.org), we identified that with the development of our 3rdAI Research Engine we had laid the groundwork for a comm",200,{"programme":8,"total":962,"withPiName":963,"firstYear":964,"lastYear":965,"countryCount":966,"perYear":967,"topInstitutions":1005,"topCountries":1073},2347,7,2014,2027,31,[968,970,973,975,977,980,983,986,989,992,995,998,1000,1003],{"year":964,"count":969},13,{"year":971,"count":972},2015,142,{"year":974,"count":972},2016,{"year":976,"count":960},2017,{"year":978,"count":979},2018,160,{"year":981,"count":982},2019,176,{"year":984,"count":985},2020,174,{"year":987,"count":988},2021,120,{"year":990,"count":991},2022,198,{"year":993,"count":994},2023,231,{"year":996,"count":997},2024,237,{"year":13,"count":999},265,{"year":1001,"count":1002},2026,264,{"year":965,"count":1004},25,[1006,1009,1012,1015,1018,1021,1024,1027,1030,1032,1034,1037,1040,1043,1045,1048,1051,1053,1056,1058,1060,1062,1065,1068,1070],{"name":1007,"count":1008},"Centre National de la Recherche Scientifique CNRS",84,{"name":1010,"count":1011},"Weizmann Institute of Science",65,{"name":1013,"count":1014},"Technion - Israel Institute of Technology",43,{"name":1016,"count":1017},"The Chancellor Masters and Scholars of the University of Cambridge",42,{"name":1019,"count":1020},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",41,{"name":1022,"count":1023},"Fondazione Istituto Italiano di Tecnologia",34,{"name":1025,"count":1026},"Tel Aviv University",33,{"name":1028,"count":1029},"Imperial College of Science Technology and Medicine",32,{"name":1031,"count":1029},"Politecnico di Milano",{"name":1033,"count":966},"Institut National de la Sante Et de la Recherche Medicale",{"name":1035,"count":1036},"Ecole Polytechnique Federale de Lausanne",30,{"name":1038,"count":1039},"Universiteit Twente",29,{"name":1041,"count":1042},"The Hebrew University of Jerusalem",28,{"name":1044,"count":1042},"Universiteit Gent",{"name":1046,"count":1047},"The Chancellor, Masters and Scholars of the University of Oxford",27,{"name":1049,"count":1050},"Danmarks Tekniske Universitet",24,{"name":1052,"count":1050},"Vib Vzw",{"name":1054,"count":1055},"Katholieke Universiteit Leuven",23,{"name":1057,"count":1055},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",{"name":1059,"count":1055},"Technische Universitaet Muenchen",{"name":1061,"count":1055},"Technische Universiteit Delft",{"name":1063,"count":1064},"The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undivided Trinity of Queen Elizabeth Near Dublin",22,{"name":1066,"count":1067},"Technische Universiteit Eindhoven",21,{"name":1069,"count":1067},"Universiteit Leiden",{"name":1071,"count":1072},"Eidgenoessische Technische Hochschule Zuerich",20,[1074,1076,1078,1080,1082,1084,1086,1088,1090,1092,1094,1096,1098,1100,1102,1104,1105,1107,1109,1111,1113,1115,1118,1120,1122],{"name":43,"count":1075},299,{"name":12,"count":1077},273,{"name":26,"count":1079},261,{"name":81,"count":1081},254,{"name":103,"count":1083},221,{"name":92,"count":1085},215,{"name":54,"count":1087},191,{"name":220,"count":1089},109,{"name":905,"count":1091},85,{"name":32,"count":1093},72,{"name":20,"count":1095},62,{"name":122,"count":1097},50,{"name":520,"count":1099},48,{"name":705,"count":1101},47,{"name":859,"count":1103},40,{"name":585,"count":1072},{"name":739,"count":1106},19,{"name":305,"count":1108},17,{"name":831,"count":1110},12,{"name":368,"count":1112},11,{"name":70,"count":1114},10,{"name":1116,"count":1117},"PL",8,{"name":1119,"count":1117},"SI",{"name":506,"count":1121},5,{"name":330,"count":1123},2]