[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-proof-of-concept-2026":3,"awarded-stats-erc-proof-of-concept":966},{"awarded":4,"total":965},[5,16,22,29,35,41,47,53,58,63,69,75,80,85,91,97,103,109,114,119,124,129,134,139,145,151,156,161,166,171,177,182,186,191,196,201,206,212,217,222,227,233,237,242,247,251,256,260,265,270,275,280,285,290,295,300,305,310,315,319,324,329,334,339,344,349,354,358,363,368,373,377,381,386,390,395,400,404,408,412,416,421,426,431,437,441,445,449,454,458,462,467,471,476,481,486,491,496,500,505,510,515,520,525,530,535,539,544,548,553,559,564,568,572,577,581,585,590,595,599,604,608,612,616,621,625,629,634,639,643,647,652,657,662,666,671,675,680,684,689,693,698,703,708,712,717,722,726,731,735,739,743,747,751,755,759,764,769,773,778,784,789,793,797,802,807,812,817,822,827,831,837,841,846,851,856,860,864,868,873,877,881,885,889,895,899,903,907,911,916,921,925,930,934,938,942,947,952,956,960],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-101335618","European Research Council","ERC Proof of Concept","Next-Generation X-Ray Laser Light Sources",null,"HEINRICH-HEINE-UNIVERSITAET DUESSELDORF","DE",2026,"€150,000","X-ray free-electron lasers (XFELs) are today’s by far most advanced technology for imaging of atomic structures and ultrafast dynamics, underpinning breakthroughs in life sciences, structural biology, materials, semiconductor and fusion science and technology. However, today’s XFELs rely on kilometre-scale underground electron accelerators housed in billion-euro facilities, restricting them to a handful of large giga-infrastructures worldwide. As a result, research teams that want to use XFELs n",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":20,"year":13,"amount":14,"abstract":21},"cordis-european-research-council-award-101335367","A Flexible Publishing Platform for Knowledge Environments: Streamlining the Creation of Interactive and  Layered Scholarship","THE HEBREW UNIVERSITY OF JERUSALEM","IL","This Proof of Concept will develop and validate a configurable platform that enables researchers to create and publish novel knowledge environments – navigable, evidence-linked digital publications that innovatively present the full relational architecture of complex scholarship. Researchers increasingly work with interconnected texts, images, objects, datasets, terminology, and layered interpretation, yet they still lack accessible technologies to publish this material while preserving its stru",{"id":23,"funder":7,"programme":8,"title":24,"piName":25,"institution":26,"country":27,"year":13,"amount":10,"abstract":28},"openalex-european-research-council-award-erc-poc-101123215","Gut microbiota generate dinitrosyl iron complexes with cardiometabolic benefits","Andrei L. Kleschyov","Karolinska Institutet","SE","Gut bacteria affect host physiology, but the underlying mechanisms are not completely understood. We identify a pathway whereby gut microbes convert inorganic nitrate and non-heme iron into mobile bioactive dinitrosyl iron complexes (DNICs) that are distributed systemically and affect host metabolism. Electron paramagnetic resonance detected DNICs in tissues of conventional but not germ-free mice. Mouse and human feces and E. coli generated DNICs from nitrate and iron citrate, whereas a nitrate-",{"id":30,"funder":7,"programme":8,"title":31,"piName":10,"institution":32,"country":33,"year":13,"amount":14,"abstract":34},"cordis-european-research-council-award-101334834","Lab-Protect: Translating phyllosphere-adapted microbial insights into a new class of lactobacilli-based biocontrol solutions","UNIVERSITEIT ANTWERPEN","BE","Transitioning to sustainable crop protection is a pillar of the European Green Deal, calling for a 50% reduction in chemical pesticide use by 2030. This requires reliable, field-robust biological alternatives. LAB-Protect builds on the ERC StG Lacto Be and aims to develop next-generation microbial biocontrol agents (MBCAs) based on plant-derived lactic acid bacteria (LAB), an underexploited yet highly promising class of beneficial microbes. One lead strain isolated from strawberry tissue shows e",{"id":36,"funder":7,"programme":8,"title":37,"piName":10,"institution":38,"country":39,"year":13,"amount":14,"abstract":40},"cordis-european-research-council-award-101334835","Real-Time Acoustic Biodiversity and Threat Monitoring in the Global South","JYVASKYLAN YLIOPISTO","FI","Biodiversity loss is accelerating, yet managers of protected areas and other local stakeholders in the Global South lack timely, affordable tools to monitor ecological change and respond to threats. Current biodiversity monitoring technologies generate vast amounts of data but results often reach local stakeholders only after long delays, undermining their practical value. BioSounds aims to transform this situation by delivering an innovative proof of concept for a real-time acoustic monitoring ",{"id":42,"funder":7,"programme":8,"title":43,"piName":10,"institution":44,"country":45,"year":13,"amount":14,"abstract":46},"cordis-european-research-council-award-101335565","Advancing the Technology of PRIME editing to broaden the scope of gene correction therapies","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","NL","Genetic disorders cause substantial childhood morbidity and mortality. They affect more than 30 million individuals in Europe alone and are estimated to cost over $1 trillion each year. Therapeutic options remain limited. \nPrime editing is an emerging precise gene-editing approach that promises causal treatment of genetic disorders by correcting the disease-causing genetic variants. Whereas conventional gene therapies add or knock out a gene, prime editing can rewrite endogenous DNA with high pr",{"id":48,"funder":7,"programme":8,"title":49,"piName":10,"institution":50,"country":51,"year":13,"amount":14,"abstract":52},"cordis-european-research-council-award-101335484","XENObiotic-based PREDiction platform of inter-individual differences in drug metabolism","UNIVERSITA DEGLI STUDI DI PARMA","IT","Inter-individual variability in drug metabolism remains a major barrier to clinical practice and drug development, often leading to adverse reactions, therapeutic inefficacy, and costly trial failures. While genetics explain only part of this variability, the contribution of the gut microbiome remains largely underestimated. The ERC-StG PREDICT-CARE project has shown that dietary (poly)phenols, a large family of plant xenobiotics metabolised through pathways that partly overlap with those involv",{"id":54,"funder":7,"programme":8,"title":55,"piName":10,"institution":56,"country":45,"year":13,"amount":14,"abstract":57},"cordis-european-research-council-award-101334519","Siderophore-mediated delivery of antibacterial antisense agents","STICHTING RADBOUD UNIVERSITEIT","Antibacterial resistance represents a major and growing threat to global public health, while the development of new antibiotics with novel mechanisms of action has largely stagnated. The SIDEROSENSE project addresses this challenge by advancing a fundamentally new antibacterial modality based on antisense technology. SIDEROSENSE enables selective intracellular delivery of antibacterial antisense oligonucleotides, overcoming a long-standing barrier to the clinical translation of antisense-based ",{"id":59,"funder":7,"programme":8,"title":60,"piName":10,"institution":61,"country":51,"year":13,"amount":14,"abstract":62},"cordis-european-research-council-award-101335267","Fully Automated Reprogramming-to-Organoid platform","FONDAZIONE PER LA RICERCA BIOMEDICA AVANZATA ETS","Patient-specific organoids derived from induced pluripotent stem cells are transforming disease modelling, drug discovery and precision medicine. However, their widespread adoption remains limited because organoid production is slow, expensive and highly dependent on manual expertise. Current workflows require multiple disconnected steps - cellular reprogramming, stem cell expansion and organoid differentiation - performed across different laboratories over several months, resulting in poor repr",{"id":64,"funder":7,"programme":8,"title":65,"piName":10,"institution":66,"country":67,"year":13,"amount":14,"abstract":68},"cordis-european-research-council-award-101335281","iChatRD: A user-centred clinical decision support system for the diagnosis of rare and inherited metabolic diseases","UNIVERSITY OF GALWAY","IE","Rare diseases, including inherited metabolic diseases (IMDs), affect ~5% of the global population, yet diagnosis often takes years, causing preventable morbidity. Many computational tools are either limited to structured phenotype inputs or operate as “black boxes” prone to errors. Within the ERC project, Avatar, we have developed ChatRD, an AI-assisted, fully transparent clinical decision support tool that suggests expert-level rare disease diagnoses from unstructured patient descriptions withi",{"id":70,"funder":7,"programme":8,"title":71,"piName":10,"institution":72,"country":73,"year":13,"amount":14,"abstract":74},"cordis-european-research-council-award-101334981","Rare Earth Element Automated Chemistry for Targeted Optimized Recovery","UNIVERZITA PALACKEHO V OLOMOUCI","CZ","Rare-earth elements (REEs) are indispensable for the energy transition, digital infrastructure, and strategic technologies, yet their sustainable separation remains a critical bottleneck. Industrial REE refining relies on a small set of legacy organic extractants developed decades ago, which show poor selectivity between chemically similar lanthanoids, require hundreds of extraction stages, generate large waste streams, and demand capital-intensive infrastructure. As a result, many European reso",{"id":76,"funder":7,"programme":8,"title":77,"piName":10,"institution":78,"country":45,"year":13,"amount":14,"abstract":79},"cordis-european-research-council-award-101335341","Synthetic Multi-timepoint AI-enhanced Breast MRI","STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM","Smart-MRI (Synthetic Multi-timepoint AI-enhanced Breast MRI) aims to eliminate the need for gadolinium-based contrast agents while preserving the diagnostic accuracy of Dynamic Contrast-Enhanced MRI (DCE-MRI).\nSmart-MRI consists of three key phases. The first phase focuses on AI model optimization and external validation. Our deep learning model is trained on a large dataset of paired contrast-enhanced and non-contrast breast MRI scans, designed to capture essential temporal and morphological fe",{"id":81,"funder":7,"programme":8,"title":82,"piName":10,"institution":83,"country":12,"year":13,"amount":14,"abstract":84},"cordis-european-research-council-award-101335035","Cryo-iLM: A High-NA Cryoimmersion Microscopy Platform for Nanometre Imaging","TECHNISCHE UNIVERSITAT DARMSTADT","Cryo-iLM aims to transfer key results from the ERC project MICROCRYO into a modular, portable cryo-immersion microscopy platform that can be adopted by the wider life-science community and integrated into existing cryo-EM laboratories. The core challenge addressed is that cryogenic fluorescence light microscopy (cryo-FLM) and cryo-correlative workflows remain limited by low numerical aperture (NA) optics and by practical barriers to combining high-performance cryogenic fluorescence imaging with ",{"id":86,"funder":7,"programme":8,"title":87,"piName":10,"institution":88,"country":89,"year":13,"amount":14,"abstract":90},"cordis-european-research-council-award-101335537","Oligonucleotide Backbone Modifications","UNIVERSITAT BASEL","CH","Therapeutic oligonucleotides are rapidly emerging as novel modalities for the treatment of several previously unaddressable diseases. The development of oligonucleotide therapeutics has thereby been significantly driven by chemical modifications that enhance nuclease resistance, pharmacokinetic properties, and target engagement. Especially the modification of the phosphorus site at the internucleoside linkage, in particular by the replacement of an oxygen with sulfur in the form of phosphorothio",{"id":92,"funder":7,"programme":8,"title":93,"piName":10,"institution":94,"country":95,"year":13,"amount":14,"abstract":96},"cordis-european-research-council-award-101335124","Continuous AMIde-band Ring-laser Array","TECHNISCHE UNIVERSITAET WIEN","AT","Widely tunable mid-infrared (mid-IR) lasers are key enabling components for chemical and bioanalytical spectroscopy. Broadband spectral access to the molecular fingerprint region is currently dominated by external-cavity quantum cascade lasers (EC-QCLs), which are bulky, expensive, and rely on mechanically tuned free-space cavities, making the laser the primary cost and architectural bottleneck in many mid-IR instruments.\n\nThis ERC PoC introduces CAMIRA, a chip-integrated mid-IR source that repl",{"id":98,"funder":7,"programme":8,"title":99,"piName":10,"institution":100,"country":101,"year":13,"amount":14,"abstract":102},"cordis-european-research-council-award-101334770","FLEX-CODESWITCH","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","UK","All current successful automatic speech recognition (ASR) systems (largely for English) are trained on hundreds of thousands of hours of training data, invariably based on individual languages. However, multilingual communities switch between two or more languages (code-switching): E What is my bank balance? Bengali\u002FE amar bank balance kɔto? (my bank balance how much). Thus, for the recognition of speech involving code-switching, recognition rates are seriously impaired. Moreover, since code-swi",{"id":104,"funder":7,"programme":8,"title":105,"piName":10,"institution":106,"country":107,"year":13,"amount":14,"abstract":108},"cordis-european-research-council-award-101335464","ERror-free CLAdded PHOtonic circuits","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","FR","Today’s nanometer-scale imprecision in the fabrication of Photonic Integrated Circuits (PICs) induce optical phase errors, with multiple negative consequences. Current error mitigation techniques negatively impact PICs energy budget, PICs complexity, PICs costs and more broadly PICs potential to scale-up. ERCLAPHO’s aim is to establish a new technique for permanently correcting these fabrication errors in cladded PICs, with the following assets: the technique is non-volatile, is specific, it imp",{"id":110,"funder":7,"programme":8,"title":111,"piName":10,"institution":112,"country":12,"year":13,"amount":14,"abstract":113},"cordis-european-research-council-award-101335506","From Research Infrastructure to Radiology AI Platform","UNIVERSITATSKLINIKUM BONN","Radiology AI faces a dual infrastructure crisis: developing next-generation AI, particularly radiology foundation models, requires access to large-scale clinical imaging data that remains siloed across hospital systems. Evaluating the growing number of commercial AI products requires the same data access, yet hospitals cannot benchmark these tools on their own patients before procurement, cannot identify performance gaps, or systematically monitor performance after deployment. We developed and o",{"id":115,"funder":7,"programme":8,"title":116,"piName":10,"institution":117,"country":45,"year":13,"amount":14,"abstract":118},"cordis-european-research-council-award-101335229","HARNESSING HETEROTYPIC T CELL CLUSTERS TO BOOST TIL CANCER THERAPY","STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS","Despite major advances in cancer immunotherapy, most patients still lack durable benefit. Tumor-infiltrating T lymphocyte (TIL) therapy can induce deep cancer remissions, but potency varies and complete clinical responses are limited to 20%. Crucially, although truly tumor-reactive T cells are rare in cancers (\u003C5%), current manufacturing protocols expand TILs in bulk, without inclusion of a selection or enrichment step. Together, these observations create both a dire clinical need and unique opp",{"id":120,"funder":7,"programme":8,"title":121,"piName":10,"institution":122,"country":51,"year":13,"amount":14,"abstract":123},"cordis-european-research-council-award-101334870","uBeAt-powered closed-loop sTandardisaTion of beatIng heart-on-chip for reliable cardioTOxicity screening","POLITECNICO DI MILANO","Drug-induced cardiotoxicity remains a primary cause of late-stage clinical attrition. Current preclinical safety assessments are focused heavily on electrophysiology assays and animal models and shows limited predictivity for human outcomes, largely failing to detect critical cardiac liabilities. \nHeart-on-Chip models represent a transformative New Approach Methodology (NAM) to address this gap. However, their routine industrial adoption is severely hindered by biological variability and a lack ",{"id":125,"funder":7,"programme":8,"title":126,"piName":10,"institution":127,"country":27,"year":13,"amount":14,"abstract":128},"cordis-european-research-council-award-101335279","Benchmarking and commercialization route for In utero engineering of mouse models with Robotics","KAROLINSKA INSTITUTET","Breakthrough biology often requires transgenic mouse models: labor-heavy, expensive, slow, and reliant on large cohorts. This ERC Proof of Concept will translate our ERC-funded breakthroughs into a disseminatable semi-automated “click-to-inject” platform for reproducible and direct in utero genetic manipulation of mouse embryos - a transformative yet technically demanding procedure for rapid, versatile, and efficient generation of mouse models, currently limited to a handful of expert laboratori",{"id":130,"funder":7,"programme":8,"title":131,"piName":10,"institution":132,"country":33,"year":13,"amount":14,"abstract":133},"cordis-european-research-council-award-101335194","In vivo validation of a novel, high precision Positive Allosteric Modulation-based therapy for immune-inflammatory diseases","VIB VZW","Immune-inflammatory diseases arise when the balance between stimulatory and inhibitory checkpoint signals is disrupted, causing excessive immune responses and ultimately breaking immune tolerance and tissue homeostasis. Current therapies either broadly suppress the immune system or block stimulatory checkpoints, but none exploit the activity of inhibitory checkpoints as a mechanism built by nature to restore immune homeostasis. This leaves a clear therapeutic gap, and an opportunity to locally c",{"id":135,"funder":7,"programme":8,"title":136,"piName":10,"institution":137,"country":51,"year":13,"amount":14,"abstract":138},"cordis-european-research-council-award-101335166","Leading small molecules for the selective protein clearance in ER disorders","FONDAZIONE TELETHON ETS","Many severe genetic and age-related diseases are driven by the accumulation of misfolded proteins within the endoplasmic reticulum, leading to chronic cellular stress, tissue damage and organ failure. Despite major advances in targeted protein degradation, no current technology can selectively eliminate toxic proteins residing inside this cellular compartment. As a result, patients affected by the so-called ER-storage diseases (e.g. collagenopathies, corneal dystrophies or serpinopathies) still ",{"id":140,"funder":7,"programme":8,"title":141,"piName":10,"institution":142,"country":143,"year":13,"amount":14,"abstract":144},"cordis-european-research-council-award-101331394","A Domain-Adapted Multimodal AI Platform for Substellar Astronomy: Foundation Models, Vision- Language Spectral Analysis, Retrieval-Augmented Generation, and Automated Research Workflows","INSTITUTO DE ASTROFISICA DE CANARIAS","ES","SubstellarLLM is the first domain-adapted multimodal AI platform designed to dramatically reduce the “Time-to-Science” for substellar astronomy—from months to minutes. It integrates a fine-tuned text foundation model, a Vision-Language Model (VLM) for automated classification of Euclid’s 2D spectral images and multi-band imaging, Retrieval-Augmented Generation (RAG), real-time public catalogue APIs (Gaia DR3, 2MASS, AllWISE, SIMBAD), and a suite of specialised tools including visual spectral cla",{"id":146,"funder":7,"programme":8,"title":147,"piName":10,"institution":148,"country":149,"year":13,"amount":14,"abstract":150},"cordis-european-research-council-award-101333547","Functionalized Glass Membranes for Resource Recovery from Waste Streams","AALBORG UNIVERSITET","DK","Desalination is an essential process for securing access to safe drinking water, but it produces large volumes of concentrated brine, which harms marine ecosystems and is costly to dispose of. Brine, however, also contains valuable elements, including EU designated Critical Raw Materials (CRMs). For example, magnesium, which is vital to pharmaceuticals, electronics, and transport, is routinely discarded. Recovering it offers environmental and economic gains and supports a circular economy, but n",{"id":152,"funder":7,"programme":8,"title":153,"piName":10,"institution":154,"country":143,"year":13,"amount":14,"abstract":155},"cordis-european-research-council-award-101335145","From waste to wealth: implementing wastewater and sewage sludge elemental phytomining (eMINING)","CENTRO DE INVESTIGACION ECOLOGICA Y APLICACIONES FORESTALES","Most wastewater treatment plants (WWTPs) release significant amounts of heavy metals and nutrients into aquatic ecosystems, threatening biodiversity and increasing the cost of reusing effluent water. Other waste products, like sewage sludge (SS), are still largely incinerated or disposed of in landfills, generating CO2 emissions and risking heavy metal leaching into water systems. The EU's Directive EU 2024\u002F3019 mandates the phased implementation of tertiary treatments, yet currently only 10-15%",{"id":157,"funder":7,"programme":8,"title":158,"piName":10,"institution":159,"country":45,"year":13,"amount":14,"abstract":160},"cordis-european-research-council-award-101335130","Automated Sequence Discovery of Elite Responder Antibodies from REVAMP Sera","UNIVERSITEIT UTRECHT","The most potent human antibodies – those secreted by plasma cells of elite responders – remain invisible to conventional single-cell BCR sequencing (scBCR-seq) and are therefore inaccessible for therapeutic discovery. Frontier research in REVAMP (ERC AdG 101141457) has pioneered a breakthrough protein-centric discovery platform, AbDirect, that directly sequences these genuine in vivo-matured antibodies from smallvolume biofluids. It captures the active molecules themselves, with preselection bef",{"id":162,"funder":7,"programme":8,"title":163,"piName":10,"institution":164,"country":12,"year":13,"amount":14,"abstract":165},"cordis-european-research-council-award-101335205","Intrinsic Flame Instabilities for Engine Control: Translating Hydrogen Combustion Physics into Control Strategies","RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN","Hydrogen internal combustion engines offer carbon-free power for applications where electrification is difficult. Ultra-lean operation enables high efficiency and low nitrogen oxides (NOx) emissions, however, under these conditions, intrinsic flame instabilities (IFIs) caused by differential diffusion of hydrogen and heat, significantly influence burning rate, pollutant formation, and thermal efficiency. These effects have a huge impact but cannot be reliably predicted by current industrial work",{"id":167,"funder":7,"programme":8,"title":168,"piName":10,"institution":169,"country":143,"year":13,"amount":14,"abstract":170},"cordis-european-research-council-award-101335517","Seebeck-unlocked photoelectrochemical fuels","UNIVERSITAT POLITECNICA DE CATALUNYA","Photoelectrochemical (PEC) processes represent a promising pathway for sustainable solar-driven chemistry. However, a fundamental bottleneck in the field is the trade-off between current and voltage: while state-of-the-art wide-bandgap photoelectrodes offer high photovoltage, they are limited by low photocurrents. Conversely, innovative narrow-bandgap photoelectrodes excel in generating high photocurrents but fail to produce the necessary photovoltage to drive the electrolytic reaction effective",{"id":172,"funder":7,"programme":8,"title":173,"piName":10,"institution":174,"country":175,"year":13,"amount":14,"abstract":176},"cordis-european-research-council-award-101335568","Wearable Cardiac Biomarker Testing at the Point of Need","KOC UNIVERSITY","TR","Every year, an estimated 2 million EU emergency ambulance transports for chest pain reach hospital without a single troponin measurement — the biomarker needed to confirm or rule out myocardial infarction (heart attack). After discharge, a substantial proportion of patients who develop post-infarction heart failure are rehospitalised within 30 days, with no tool to monitor troponin at home. This gap persists because troponin circulates at concentrations orders of magnitude lower than glucose, th",{"id":178,"funder":7,"programme":8,"title":179,"piName":10,"institution":180,"country":45,"year":13,"amount":14,"abstract":181},"cordis-european-research-council-award-101335007","Multimaterial High-Entropy Anodes for Green Hydrogen","UNIVERSITEIT TWENTE","Affordable green hydrogen requires durable electrolyzer materials that  avoid scarce precious metals such as iridium.\n\nHEA-H2 addresses this challenge by establishing a multilayer anode technology based on high-entropy oxide (HEO) materials, recently disclosed in a patent application. The invention integrates these new catalyst materials into engineered multilayer electrode architectures that substantially improve the oxygen evolution reaction, the main efficiency bottleneck in water electrolysi",{"id":183,"funder":7,"programme":8,"title":184,"piName":10,"institution":83,"country":12,"year":13,"amount":14,"abstract":185},"cordis-european-research-council-award-101335589","An LLM-Resilient Tool for Safe RTL Sharing","Modern chips are no longer designed in isolation. Instead, they are assembled from numerous third-party intellectual property (IP) blocks that are exchanged and reused across complex global supply chains. While this modular ecosystem is convenient for development, it also exposes valuable design assets to reverse engineering and unauthorized reuse. These risks are rapidly increasing with the emergence of AI models for code understanding, such as large language models, which can infer the functio",{"id":187,"funder":7,"programme":8,"title":188,"piName":10,"institution":189,"country":101,"year":13,"amount":14,"abstract":190},"cordis-european-research-council-award-101335624","Safer Therapeutics Through Early Toxicity Detection","QUEEN MARY UNIVERSITY OF LONDON","The development of safer and more effective medicines is constrained by the late detection of drug-induced toxicity, one of the principal causes of attrition during drug development and a major contributor to escalating costs. Existing screening strategies are primarily designed to identify target engagement, whereas toxic liabilities frequently become apparent only during advanced preclinical studies or clinical trials, resulting in costly failures and significant delays in bringing new therapi",{"id":192,"funder":7,"programme":8,"title":193,"piName":10,"institution":194,"country":143,"year":13,"amount":14,"abstract":195},"cordis-european-research-council-award-101335459","Map for the Mediterranean: A Scalable Four-Dimensional Application to Manage Data on a Deep Environment","UNIVERSIDAD DE SEVILLA","MAP FOR THE MEDITERRANEAN: A Scalable Four-Dimensional Application to Manage Data on a Deep Environment.\nThe Mediterranean Sea is among the most complex regions globally, facing acute geopolitical and environmental tensions. The challenges it faces, and the opportunities it presents, extend beyond the surface into the deep waters, making traditional bidimensional mapping from above inadequate for analysis, teaching, and decision-making. Moreover, historical and scientific data on the Mediterrane",{"id":197,"funder":7,"programme":8,"title":198,"piName":10,"institution":199,"country":51,"year":13,"amount":14,"abstract":200},"cordis-european-research-council-award-101333614","SMART-SMAPs: a new paradigm of cell-free cytotoxic immunotherapy for resistant CLL","UNIVERSITA DEGLI STUDI DI SIENA","Chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia, with ~32,000 new cases annually in Europe and a disease burden that has more than doubled over the past three decades. Despite significant advances with BTK and BCL-2 inhibitors, CLL remains incurable. Acquired resistance driven by the immunosuppressive tumour microenvironment (TME) leads to inevitable relapse in most patients. This challenge is shared across B-cell neoplasias, including non-Hodgkin lymphoma, diffuse large ",{"id":202,"funder":7,"programme":8,"title":203,"piName":10,"institution":204,"country":20,"year":13,"amount":14,"abstract":205},"cordis-european-research-council-award-101334790","Progressive lenses on the spot  -  reimagining the ophthalmic value chain","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","In this PoC we propose to develop a Progressive Lens Generator – a device that will enable rapid, wasteless, and automated end-to-end fabrication of high-quality multifocal ophthalmic lenses, without relying on capital-intensive surfacing infrastructure or centralized manufacturing facilities. The device will be based on our ERC-funded technology, which allows the formation of high-quality optical elements. As part of the ERC, we have already demonstrated fabrication of single-vision lenses in u",{"id":207,"funder":7,"programme":8,"title":208,"piName":10,"institution":209,"country":210,"year":13,"amount":14,"abstract":211},"cordis-european-research-council-award-101335219","Stretchable Mechanosensors for Quantitative Musculoskeletal Monitoring and Rehabilitation","UNIVERSIDADE DE COIMBRA","PT","Musculoskeletal (MSK) disorders are among the leading causes of disability worldwide and represent a major burden for healthcare systems. Despite the increasing demand for rehabilitation, progress assessment in clinical practice remains largely qualitative and relies on subjective evaluation by therapists. Existing wearable technologies can measure electrical muscle activity or estimate joint motion indirectly, but they cannot directly capture the mechanical behavior of muscles and joints, which",{"id":213,"funder":7,"programme":8,"title":214,"piName":10,"institution":215,"country":20,"year":13,"amount":14,"abstract":216},"cordis-european-research-council-award-101331454","Enzymatic STEreospecific RNA phosphorothioate modification for next-generation therapeutics","WEIZMANN INSTITUTE OF SCIENCE","RNA therapeutics have emerged as a powerful medical modality, from COVID-19 vaccines to treatments for rare genetic diseases and cancer. However, a fundamental bottleneck limits their potential: RNA instability. Most approved RNA drugs rely on phosphorothioate (PS) modifications for stability and delivery, but current chemical synthesis produces stereochemical mixtures reducing efficacy, increasing toxicity, and complicating regulatory approval. Moreover, chemical PS synthesis is restricted to s",{"id":218,"funder":7,"programme":8,"title":219,"piName":10,"institution":220,"country":107,"year":13,"amount":14,"abstract":221},"cordis-european-research-council-award-101334815","Sustainable Marine Autonomous Real-Time Platform Technology","INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT","Plankton drives the ocean’s biological carbon pump, regulating climate and sustaining marine ecosystems. Yet its dynamics remain largely unobserved because current technologies cannot deliver continuous, high-frequency (hour, day), vertically integrated measurements. This observational gap limits our ability to understand and predict ocean services such as climate regulation. The ERC HOPE project demonstrated the feasibility of autonomous offshore monitoring, deploying a prototype integrating 12",{"id":223,"funder":7,"programme":8,"title":224,"piName":10,"institution":225,"country":33,"year":13,"amount":14,"abstract":226},"cordis-european-research-council-award-101335560","From Discovery to Scale – Precision Membranes for Critical Ion Recovery","KATHOLIEKE UNIVERSITEIT LEUVEN","The rapid electrification of mobility and energy systems is driving an unprecedented demand for critical raw materials including lithium. Yet current lithium supply chains remain highly inefficient, resulting in significant loss of valuable metals and minerals to processing and waste streams, because of low efficiency of the existing separation technologies in handling complex, high-salinity streams. Membrane technology is emerging as a promising solution because of its versatility. However, con",{"id":228,"funder":7,"programme":8,"title":229,"piName":10,"institution":230,"country":231,"year":13,"amount":14,"abstract":232},"cordis-european-research-council-award-101334972","Closed-loop machine learning platform for the optimisation of battery materials","UNIVERSITE DU LUXEMBOURG","LU","BATMAT will deliver a proof-of-concept, closed-loop machine-learning platform that makes high-fidelity, first-principles screening of battery materials practical for industrial decision cycles. Battery R&D is increasingly constrained by late discovery of instability, slow ion transport, or reactive interfaces, i.e. failure modes that often require expensive electronic-structure simulations under realistic conditions (defects, diffusion pathways, interphases). Building on algorithms and software ",{"id":234,"funder":7,"programme":8,"title":235,"piName":10,"institution":215,"country":20,"year":13,"amount":14,"abstract":236},"cordis-european-research-council-award-101335588","Unlocking Immunotherapy Potential with CapCure: A Novel Chemical Antagonist of PSME4","Immunotherapy has transformed cancer treatment, yet many patients fail to benefit because their tumors develop intrinsic mechanisms to block immune attack. Recent discoveries from our ERC-funded work revealed that the proteasome, a central protein degradation system, can be hijacked by tumors to suppress immune recognition and promote an immunosuppressive environment.\n\nThis Proof of Concept project aims to translate these findings into a novel therapeutic approach. We will develop and validate s",{"id":238,"funder":7,"programme":8,"title":239,"piName":10,"institution":240,"country":45,"year":13,"amount":14,"abstract":241},"cordis-european-research-council-award-101335091","Immuno-Modulatory Platform for Advanced CLL Therapy","STICHTING AMSTERDAM UMC","This project aims to advance a first-in-class\u002Fbest-in-disease novel trispecific T cell engager, TRIDENT-19, with improved efficacy as compared to standard CD3-based bispecifics as it overcomes tumor-associated T cell dysfunction. Multispecific antibodies (MA) enable simultaneous engagement of immune effector cells and tumor cells. Crosstalk within the tumor microenvironment frequently impairs T cell function, leading to partial and short-lived responses to CD3-engaging multispecific antibodies i",{"id":243,"funder":7,"programme":8,"title":244,"piName":10,"institution":245,"country":149,"year":13,"amount":14,"abstract":246},"cordis-european-research-council-award-101334897","Ultrafast Superconducting Nanowire Single-Photon Detectors","DANMARKS TEKNISKE UNIVERSITET","\"In photonic quantum technologies, quantum information is encoded in single photons that can be entangled and used for quantum computing or transmitted through optical fibers for secure quantum communication. Unlocking their full potential requires high-speed operation. While single photons can now be generated at gigahertz rates, state-of-the-art single-photon detectors remain limited to the megahertz regime due to long recovery times inherent to conventional superconducting nanowires. This fun",{"id":248,"funder":7,"programme":8,"title":249,"piName":10,"institution":180,"country":45,"year":13,"amount":14,"abstract":250},"cordis-european-research-council-award-101335553","The Multi-Heart Plate: a human engineered mini-heart platform for functional cardiac disease modelling and drug testing","Cardiovascular diseases remain a leading cause of mortality worldwide, yet drug development is hampered by the lack of predictive human models that capture cardiac function. In particular, diastolic dysfunction and heart failure with preserved ejection fraction represent major unmet medical needs, partly because current preclinical models inadequately reproduce human cardiac physiology. This HEARTPUMP project aims to explore the innovation potential of the Multi-Heart Plate (MHP), a novel human ",{"id":252,"funder":7,"programme":8,"title":253,"piName":10,"institution":254,"country":95,"year":13,"amount":14,"abstract":255},"cordis-european-research-council-award-101335096","From Nano to Micro – Enabling Quantitative Particle Analysis Across Scales","UNIVERSITAET GRAZ","Single particle ICP-MS (SP ICP-MS) has become a powerful method for the analysis of particulate matter. While it excels for the characterisation of nanoparticulate matter, its application in the micrometre range remains limited. This is anchored in a non-constant particle transport efficiency, which rapidly declines as sizes of particles increase. This analytical blind spot limits the integration of SP ICP-MS into regulatory frameworks as well as for single cell application in life sciences and ",{"id":257,"funder":7,"programme":8,"title":258,"piName":10,"institution":174,"country":175,"year":13,"amount":14,"abstract":259},"cordis-european-research-council-award-101335111","Universal Communication Data-Path Monitoring and Visualization for Sustainable AI and HPC","Many of today’s AI and HPC workloads rely on large GPU clusters, and their scalability depends strongly on GPU-to-GPU communication performance. Yet existing tracing tools provide only fragmented visibility into multi-GPU communication. They either capture only one layer of the software stack, expose aggregate network metrics, or remain tied to a single vendor. This makes it difficult to identify communication issues, verify system configurations, and improve performance at scale. This Proof of ",{"id":261,"funder":7,"programme":8,"title":262,"piName":10,"institution":263,"country":45,"year":13,"amount":14,"abstract":264},"cordis-european-research-council-award-101334969","Hydrogel-nanoparticle delivery platform for LOCALized CAR-M immunotherapy","TECHNISCHE UNIVERSITEIT EINDHOVEN","LOCAL-CAR is a Proof-of-Concept project aimed at validating a modular hydrogel-based platform for localized mRNA immunotherapy, targeting peritoneal tumor burden in ovarian and colorectal cancer models. Building on ERC-funded technologies – ABGel and aNP-mRNA – the project integrates these into a single ABGel-mRNA system for sustained intraperitoneal immunotherapy. The platform will generate HER2-CAR-expressing macrophages (CAR-M) directly within the peritoneal cavity, enabling local anti-HER2-t",{"id":266,"funder":7,"programme":8,"title":267,"piName":10,"institution":268,"country":51,"year":13,"amount":14,"abstract":269},"cordis-european-research-council-award-101335571","Targeting Glutamine (Q) Metabolism in the Renal Ciliopathies","OSPEDALE SAN RAFFAELE SRL","Polycystic Kidney Disease (PKD) is one of the most common monogenic disorders and a major genetic cause of kidney failure. The disease is characterised by progressive formation of fluid-filled cysts originating from renal tubular epithelial cells, ultimately leading to loss of kidney function and the need for dialysis or transplantation. Both autosomal dominant and recessive forms belong to the renal ciliopathies, a group of genetic disorders caused by dysfunction of the primary cilium, a cellul",{"id":271,"funder":7,"programme":8,"title":272,"piName":10,"institution":273,"country":107,"year":13,"amount":14,"abstract":274},"cordis-european-research-council-award-101335317","SUPERconducting circuits for QUantum SENSing of microwave radiations.","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","Detecting microwave signals with ultimate sensitivity is critical to dark matter research, atomic-scale magnetic resonance, and quantum computing. The most sensitive microwave detectors available today — superconducting Josephson amplifiers — are fundamentally limited by the standard quantum limit (SQL). Within my ERC Starting Grant INGENIOUS, I developed the Single Microwave Photon Detector (SMPD), a superconducting quantum device that counts individual microwave photons and surpasses the SQL b",{"id":276,"funder":7,"programme":8,"title":277,"piName":10,"institution":278,"country":45,"year":13,"amount":14,"abstract":279},"cordis-european-research-council-award-101335049","Vision with Ionic Spatiotemporal Perovskite Arrays","STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN","The rapid growth of light detectors is generating vast amounts of data, challenging conventional computing with high energy consumption and latency. This project introduces a hardware platform for in-sensor spatiotemporal processing using arrays of perovskite optomorphic devices, which exploit light-sensitive ionic migration to encode temporal information directly in hardware. Each device acts as a slow, light-modulated capacitor, retaining traces of optical signals that allow reconstruction of ",{"id":281,"funder":7,"programme":8,"title":282,"piName":10,"institution":283,"country":89,"year":13,"amount":14,"abstract":284},"cordis-european-research-council-award-101335018","NeoVena: A Bioresorbable Polymeric Venous Valve","UNIVERSITAT ZURICH","Chronic Venous Insufficiency (CVI) is a highly prevalent and debilitating vascular disorder affecting more than 200 million people worldwide. CVI develops when venous valves in the legs fail, leading to reflux, venous hypertension, blood pooling, pain, edema, skin changes, and, in severe cases, non-healing ulcers. Current treatments such as compression stockings, venoplasty, or bypass surgery alleviate symptoms but do not restore valve function, and despite decades of research there is still no ",{"id":286,"funder":7,"programme":8,"title":287,"piName":10,"institution":288,"country":67,"year":13,"amount":14,"abstract":289},"cordis-european-research-council-award-101334807","Identifying physeal cell surface markers for paediatric growth modulation","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","Disorders of skeletal growth in children represent a significant clinical challenge affecting stature, limb alignment and function. Longitudinal bone growth is driven by the physis (growth plate), a specialised cartilaginous tissue that integrates endocrine, metabolic and biomechanical signals to regulate bone elongation. Despite its central role in skeletal development, there is currently no strategy to selectively target the physis for therapeutic intervention. Existing treatments rely on syst",{"id":291,"funder":7,"programme":8,"title":292,"piName":10,"institution":293,"country":12,"year":13,"amount":14,"abstract":294},"cordis-european-research-council-award-101335531","Sat4Com - Small Satellite Formation Technologies for Commercialisation","ZENTRUM FUR TELEMATIK EV","The ERC Synergy Grant CloudCT addressed worldwide first time a self-organizing formation of ten cooperating small satellites (PI Schilling) to generate appropriate data for computed tomography methods (PI Schechner) to characterize composition of cloud interior, providing crucial inputs for improved climate predictions (PI Koren). The satellites are in final implementation stage for launch in 2027. Thus, it is appropriate timing to address in this PoC-proposal bridging to exploit broader commerc",{"id":296,"funder":7,"programme":8,"title":297,"piName":10,"institution":298,"country":45,"year":13,"amount":14,"abstract":299},"cordis-european-research-council-award-101335628","Compact ultra-high-Q optomechanical sensors","TECHNISCHE UNIVERSITEIT DELFT","Recent advances in high-stress silicon nitride membranes have enabled some of the most sensitive room-temperature force and displacement measurements ever demonstrated. These ultrathin membranes combine exceptional mechanical performance with very low optical absorption, making them one of the strongest platforms for cavity optomechanics and precision sensing. However, despite their extraordinary capabilities, such systems have remained largely confined to specialist laboratories because they ty",{"id":301,"funder":7,"programme":8,"title":302,"piName":10,"institution":303,"country":12,"year":13,"amount":14,"abstract":304},"cordis-european-research-council-award-101334721","Breaking sample size limitations for laser ablation through novel large cell technology","ALFRED-WEGENER-INSTITUT HELMHOLTZ-ZENTRUM FUR POLAR- UND MEERESFORSCHUNG","Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS), a key technology for micro-destructive sample analysis in industry and academia, is fundamentally limited by small sample chambers (typically 10 cm). This restriction forces the destructive cutting of valuable samples and significantly impedes high-throughput analysis. For decades, commercial manufacturers regarded this sample size limitation as a fundamental technological barrier: large sample volumes challenge fast aeroso",{"id":306,"funder":7,"programme":8,"title":307,"piName":10,"institution":308,"country":45,"year":13,"amount":14,"abstract":309},"cordis-european-research-council-award-101333636","Base editing against cancer – a gene correction strategy for rhabdoid tumours","PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV","Malignant rhabdoid tumours (MRTs) are among the most aggressive paediatric cancers, with overall survival rates below 30%. The genetic hallmark of MRTs is the biallelic inactivation of SMARCB1 (or, rarely, SMARCA4). This single-driver, loss-of-function alteration disrupts epigenetic regulation, leading to uncontrolled proliferation and impaired differentiation. Unlike many cancers with complex mutational landscapes, MRTs are largely epigenetically driven, which raises the possibility that restor",{"id":311,"funder":7,"programme":8,"title":312,"piName":10,"institution":313,"country":143,"year":13,"amount":14,"abstract":314},"cordis-european-research-council-award-101335360","Quantum-Coherent Optoelectronic Platform for Ultra-Early Detection of Oncometabolites","FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA","Early cancer detection remains a critical unmet medical need, as most diagnostic technologies only identify tumours after macroscopic lesions have formed. Mutations in isocitrate dehydrogenase (IDH1\u002F2) produce the oncometabolite D-2-hydroxyglutarate (D-2HG), an early biochemical marker detectable in blood and urine. Current detection methods rely on chromatographic or enzymatic assays that require complex equipment, extensive sample preparation, and often struggle with sensitivity at very low co",{"id":316,"funder":7,"programme":8,"title":317,"piName":10,"institution":204,"country":20,"year":13,"amount":14,"abstract":318},"cordis-european-research-council-award-101335515","Pulsed Electron Microscopy for Active Metrology of Semiconductor Devices","Scanning electron microscopy (SEM) is a cornerstone of semiconductor metrology and inspection, yet it faces a fundamental limitation: it can only image static device structures. Modern semiconductor devices operate at multi-GHz frequencies, and their electrical functionality is typically characterized separately and late in the fabrication chain. This separation complicates the localization of dynamic failure modes and slows the feedback loop between device design and manufacturing. While attemp",{"id":320,"funder":7,"programme":8,"title":321,"piName":10,"institution":322,"country":27,"year":13,"amount":14,"abstract":323},"cordis-european-research-council-award-101335330","From rat to human: Patient-specific rehabilitation for Achilles tendon regeneration","LUNDS UNIVERSITET","Fifteen million tendon and ligament injuries occur annually worldwide, with the Achilles tendon among the most frequently injured. Tendons are mechanosensitive tissues, and controlled mechanical loading can promote healing, whereas inappropriate loading may cause re-rupture or impaired regeneration. However, optimal loading magnitude and timing remain unclear, leading to impaired healing, prolonged sick-leave and reduced physical activity after injury. This project presents a tool to improve and",{"id":325,"funder":7,"programme":8,"title":326,"piName":10,"institution":327,"country":12,"year":13,"amount":14,"abstract":328},"cordis-european-research-council-award-101335402","Inflaming the microenvironment of colorectal cancer to enable immunotherapy","CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS STIFTUNG","Microsatellite-stable colorectal cancer (MSS CRC) accounts for 85–90% of CRCs and remains largely resistant to immune checkpoint blockade (ICB), one of the most transformative advances in oncology. Consequently, the majority of patients with advanced CRC cannot benefit from immunotherapy, representing a major unmet clinical need. INFLAME-TME proposes a novel strategy to overcome this limitation by converting immunologically “cold” MSS tumors into ICB-responsive lesions through targeted induction",{"id":330,"funder":7,"programme":8,"title":331,"piName":10,"institution":332,"country":20,"year":13,"amount":14,"abstract":333},"cordis-european-research-council-award-101335424","Bioactive Peptide-based Hydrogels for Alveolar Bone Regeneration","TEL AVIV UNIVERSITY","Tooth loss and the resulting alveolar bone resorption are highly prevalent conditions, particularly in aging populations and in patients suffering from inflammatory periodontal diseases. Dental implants are the preferred solution for replacing missing teeth; however, successful implantation requires sufficient alveolar bone volume. Bone resorption frequently leads to unfavorable conditions of the alveolar ridge, making socket preservation and bone augmentation procedures necessary to regenerate ",{"id":335,"funder":7,"programme":8,"title":336,"piName":10,"institution":337,"country":89,"year":13,"amount":14,"abstract":338},"cordis-european-research-council-award-101334478","DaCe GPT","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","Modern high-performance processors increasingly rely on parallelism and specialized memory hierarchies, but legacy codebases struggle to harness these advances. Optimizing such applications is essential for energy efficiency and performance but requires expertise in performance engineering. Domain scientists, faced with the growing demand for computational throughput, are forced to be low-level programming experts. Worse, performance tuning often leads to non-local changes across large codebases",{"id":340,"funder":7,"programme":8,"title":341,"piName":10,"institution":342,"country":107,"year":13,"amount":14,"abstract":343},"cordis-european-research-council-award-101335332","Multispecific theranostic nano-engager platform","INSTITUT GUSTAVE ROUSSY","\"This ERC Proof of Concept proposal develops \"\"Nano-BITE,\"\" a multifunctional nanoparticle platform addressing limitations of current cancer immunotherapy. Existing bispecific antibodies like blinatumomab suffer from rapid kidney clearance due to small molecular size, requiring continuous intravenous infusion for weeks and showing poor efficacy in solid tumors. The Nano-BITE platform uses PLGA nanoparticles as scaffolds incorporating four integrated features: modular E3\u002FK3 peptide chemistry enab",{"id":345,"funder":7,"programme":8,"title":346,"piName":10,"institution":347,"country":12,"year":13,"amount":14,"abstract":348},"cordis-european-research-council-award-101330854","Glyco-guided effectors for selective labeling of galectins","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","Galectins are a family of glycan binding proteins that play central roles in immunity, inflammation and cancer. They are widely recognized targets in basic research as well as in diagnostic and therapeutic development, making tools that selectively label galectins highly valuable. However, current commercial options either rely on recombinant galectins which are labelled ex situ and subsequently added into target cell lines or on antibody based assays that are excellent for in vitro quantificati",{"id":350,"funder":7,"programme":8,"title":351,"piName":10,"institution":352,"country":12,"year":13,"amount":14,"abstract":353},"cordis-european-research-council-award-101335067","Critical Material Extraction from Low Concentration Sources","FORSCHUNGSZENTRUM JULICH GMBH","Modern secondary urban mining streams contain valuable critical metals at concentrations comparable to natural ores, yet these materials are rarely recovered. Photovoltaic (PV) waste illustrates this challenge: although each module contains several grams of silver, the metal is dispersed across large material masses and is typically not recovered by existing recycling processes. Current metallurgical approaches require large, centralized facilities and are poorly suited for heterogeneous, low-co",{"id":355,"funder":7,"programme":8,"title":356,"piName":10,"institution":298,"country":45,"year":13,"amount":14,"abstract":357},"cordis-european-research-council-award-101325529","AeRoacoustics of Turbulent gust Insensitive Shape Tailored Airfoils: for the next generation of rotors","Conventional rotors are intrinsically sensitive to turbulent inflow. This sensitivity translates directly into thrust oscillations, unsteady loading noise, loss of controllability and efficiency, and conservative certification margins. For the next-generation propulsion concepts, including open rotors, advanced turboprops and “low-altitude economy” vehicles, this sensitivity represents a recognised deployment and certification blocker.\n\nThe ARTISTA project addresses this blocker, building on a f",{"id":359,"funder":7,"programme":8,"title":360,"piName":10,"institution":361,"country":210,"year":13,"amount":14,"abstract":362},"cordis-european-research-council-award-101248627","MetaBoost: Metabolic Reprogramming for Neuronal Differentiation","UNIVERSIDADE NOVA DE LISBOA","\"The transition from glycolytic to oxidative phosphorylation (OxPhos) metabolism is crucial for proper neuronal differentiation and maturation, a key process in generating functional neurons essential for advancing neuroscience research and therapeutic applications. However, commercially available media to generate neurons often overlook this key metabolic transition. MetaBoost aims to fill this gap by developing an innovative, easy-to-use, universally compatible media supplement that induces me",{"id":364,"funder":7,"programme":8,"title":365,"piName":10,"institution":366,"country":143,"year":13,"amount":14,"abstract":367},"cordis-european-research-council-award-101289893","Spatial Awareness Avionics Network for Drone Swarms Aerosense","UNIVERSIDAD DE GRANADA","The drone swarm revolution promises to transform industries from defense to disaster relief, yet a fundamental bottleneck prevents its realization. Current systems lack true distributed spatial awareness—the ability for each drone to understand not only its neighbor’s positions but the swarm’s overall distribution. Today’s swarms rely on either centralized coordination or generic protocols that saturate with few units, forcing a tradeoff: accept external dependencies like GPS, or endure non-scal",{"id":369,"funder":7,"programme":8,"title":370,"piName":10,"institution":371,"country":12,"year":13,"amount":14,"abstract":372},"cordis-european-research-council-award-101293142","AI-guided personalized T cell receptor transgenic T cell therapy against cancer","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","\"Personalised T cell therapy has shown remarkable success in cancer therapy, however the antigens that T cells recognize to kill tumor cells are dependent on the individual tumor, T cell receptor (TCR) profile and antigen presentation machinery. AI-TreatCancer will leverage predicTCR, a proprietary AI-guided classifier that identifies tumor-killing TCRs from patient samples, decreasing the time to identify therapeutic TCRs from 3-4 months to under 2 weeks. \nIn the ERC Advanced Grant (ERC-2023-AD",{"id":374,"funder":7,"programme":8,"title":375,"piName":10,"institution":194,"country":143,"year":13,"amount":14,"abstract":376},"cordis-european-research-council-award-101291046","AI-Powered Clinical Decision Support System to Integrate Perinatal Mental Health into Routine Maternal Healthcare","Perinatal mental disorders, affecting one in five individuals from pregnancy to one year postpartum, are the most common complications of childbearing. Despite their significant impact on parents, children, and healthcare systems, preventive care remains limited due to an implementation gap. The ERC Starting Grant e-Perinatal developed and tested the ‘e-Perinatal App’, a mobile health intervention for women and partners, showing high acceptability and potential to prevent PMDs in routine care.\nB",{"id":378,"funder":7,"programme":8,"title":379,"piName":10,"institution":278,"country":45,"year":13,"amount":14,"abstract":380},"cordis-european-research-council-award-101293303","From Polymorphs of Racemic Compounds to Enantiopure Crystals","The molecular building blocks of life—such as sugars and amino acids—are of only one handedness. This broken molecular symmetry has important consequences for bioactive compounds: a molecule of one handedness can be an effective medicine while its mirror image is extremely toxic. Unfortunately, common chemical processes automatically yield both left- and right-handed molecules (i.e. enantiomers), and routes towards single handedness are often complicated, cumbersome, and costly. Therefore, there",{"id":382,"funder":7,"programme":8,"title":383,"piName":10,"institution":384,"country":143,"year":13,"amount":14,"abstract":385},"cordis-european-research-council-award-101292669","Transformative Thin-Film Technologies: Harnessing Perovskite for Reliable and Sustainable Solar Energy – RISE","UNIVERSITAT DE BARCELONA","Halide perovskites have shown significant progress in the fabrication of solar cells and have leverage on light-emitting diodes, photodetectors, memristors, and energy devices. In halide perovskites, the defects stem from the imperfection of grains and lead to electrical losses, which can be suppressed by developing a microcrystal technology. To unlock the full potential of perovskites as a semiconductor pigment, we propose to scale up the microcrystal methodology, which we have developed in the",{"id":387,"funder":7,"programme":8,"title":388,"piName":10,"institution":220,"country":107,"year":13,"amount":14,"abstract":389},"cordis-european-research-council-award-101292469","LOKI: Loiasis-associated chronic kidney disease – towards clinical recognition and policy action","Chronic Kidney Disease (CKD) is an urgent but underrecognized health challenge in Central Africa, where diagnostic capacity is limited and renal replacement therapy is rare. While established drivers such as HIV, hypertension, and diabetes are acknowledged, the contribution of neglected tropical diseases remains unexplored. Loiasis, caused by the filarial parasite Loa loa and endemic in forested rural zones where >30% of adults are infected, has long been considered benign. Yet decades of case r",{"id":391,"funder":7,"programme":8,"title":392,"piName":10,"institution":393,"country":39,"year":13,"amount":14,"abstract":394},"cordis-european-research-council-award-101286968","Responsive VR for urban sustainability: Promoting inclusion through affect-aware and behaviour-sensitive immersion","TAMPEREEN KORKEAKOULUSAATIO SR","VR-Sense is a proof-of-concept project that explores how virtual reality (VR) can be harnessed to promote sociopolitical aims. Urban planning is currentVR-Sense is a proof-of-concept project that explores how virtual reality (VR) can be harnessed to promote inclusive urban development and foster peaceful coexistence. Building on the ERC Starting Grant project EmergentCommunity, which combined experimental emotion research with qualitative studies on urban life, VR-Sense investigates how immersiv",{"id":396,"funder":7,"programme":8,"title":397,"piName":10,"institution":398,"country":101,"year":13,"amount":14,"abstract":399},"cordis-european-research-council-award-101293153","Bright and Compact Tuneable Far-Ultraviolet Light Sources for Industrial Applications","HERIOT-WATT UNIVERSITY","This ERC Proof of Concept project aims to validate a novel Far-Ultraviolet (FUV) light source technology for industrial material processing, addressing a critical bottleneck in precision manufacturing. Current FUV lasers are limited by poor beam quality, low efficiency, or high cost. Our solution, based on Resonant Dispersive-Wave (RDW) emission in gas-filled hollow-core fibres (HCFs), overcomes these limitations by offering high brightness (M2≈1), high optical efficiency (up to 15%), continuous",{"id":401,"funder":7,"programme":8,"title":402,"piName":10,"institution":50,"country":51,"year":13,"amount":14,"abstract":403},"cordis-european-research-council-award-101288914","Seeing from a subjective viewpoint:  Wireless magnetic tracking of eye position during natural vision and sleep","Monitoring subjects' eye movement is crucial for neuroscientific research on perceptual, cognitive, and motor processes in health and disease, as well as sleep studies. In these fields, animal models - particularly non-human primates (NHPs) - remain essential. Traditional eye-tracking systems require a still head, conflicting with demand for ecologically relevant approaches to study spontaneous behavior driven by the spreading of wireless neural recording technologies. Yet a commercial device fo",{"id":405,"funder":7,"programme":8,"title":406,"piName":10,"institution":66,"country":67,"year":13,"amount":14,"abstract":407},"cordis-european-research-council-award-101293238","Uro-Lieve: Slow-Release Capsaicin Hydrogel for Disease-Modifying Therapy of Painful Bladder Syndrome","Painful Bladder Syndrome\u002FInterstitial Cystitis (IC\u002FBPS) is a chronic, debilitating pelvic pain condition that affects millions of predominantly female patients and lacks an effective, long-lasting therapy. Existing treatments—including oral drugs, intravesical instillations, and neuromodulation—are largely palliative, short-lived, or poorly tolerated. A promising therapeutic approach based on selective desensitisation of bladder pain fibres has shown prolonged analgesic potential in clinical stu",{"id":409,"funder":7,"programme":8,"title":410,"piName":10,"institution":278,"country":45,"year":13,"amount":14,"abstract":411},"cordis-european-research-council-award-101293309","Zero-power acoustic emission monitoring for wind turbine blades","Damage in composite wind turbine blades generates high-frequency acoustic emission (AE) signals as it forms—the earliest warning of incipient failure, often manifesting months before other signatures appear. Yet AE monitoring has seen limited adoption: current systems are expensive, power-hungry, fragile, and require dense sensor networks. I propose a zero-power, battery-free MEMS sensor that passively recognizes and remembers AE events using a mechanical neural network. Fabricated at ultra-low ",{"id":413,"funder":7,"programme":8,"title":414,"piName":10,"institution":106,"country":107,"year":13,"amount":14,"abstract":415},"cordis-european-research-council-award-101292719","DIfferential Operator for Non-ionizing Imaging of breast tumors with Speed-Of-Sound","Breast cancer remains the most common cancer and leading cause of cancer-related death in women in the EU. Although mammography is the gold standard for screening, it suffers from key limitations: it is ionizing, painful, and shows reduced sensitivity for dense breasts—a group already at higher risk. As a result, there is a critical need for a non-invasive, non-ionizing, and more effective imaging method to improve screening coverage and diagnostic accuracy.\n\nUltrasound is a promising alternativ",{"id":417,"funder":7,"programme":8,"title":418,"piName":10,"institution":419,"country":12,"year":13,"amount":14,"abstract":420},"cordis-european-research-council-award-101292498","An AI Agent to Support Environmental Intelligence by Interacting with Copernicus Earth Observation Data","TECHNISCHE UNIVERSITAT BERLIN","With the unprecedented advances in the satellite technology, recent years have led to a significant increase in the volume of Earth observation (EO) data archives. In particular, through the Copernicus programme, which is the European flagship satellite initiative in EO, Sentinel satellites acquire a volume of roughly 20TB satellite images per day and the total size of the Copernicus data archives is almost a volume of 40PB. Thus, there has been a growing need for accurate and scalable technique",{"id":422,"funder":7,"programme":8,"title":423,"piName":10,"institution":424,"country":107,"year":13,"amount":14,"abstract":425},"cordis-european-research-council-award-101292889","A cardiac magnetic resonance solution to deliver a fast, fully automated, and comprehensive diagnostic assessment and interpretation of the patient’s cardiovascular health","UNIVERSITE DE BORDEAUX","HEARTERIX aims to evaluate the technical, clinical, and commercial feasibility of an innovative ERC-based technology that combines advanced image processing, artificial intelligence, and cutting-edge magnetic resonance imaging (MRI) solutions to automate and expedite the analysis and diagnosis of cardiac diseases. This technology has the potential to transform the clinical management of cardiac diseases by enhancing decision-support accuracy and improving efficiency through automatization. The g",{"id":427,"funder":7,"programme":8,"title":428,"piName":10,"institution":429,"country":12,"year":13,"amount":14,"abstract":430},"cordis-european-research-council-award-101292915","Neuro-Symbolic Agentic AI Research Assistant","GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER","This PoC transforms our Neuro-Symbolic Science Knowledge Graph research into a deployable Research AIssistant that fuses large language models with the Open Research Knowledge Graph (ORKG). The assistant delivers knowledge-augmented generation grounded in structured, citable research contributions, with mandatory citations, constraint checks for study and method semantics, and uncertainty signalling. Building on results from the ERC-funded ScienceGraph project—now embodied in the ORKG and ORKG-A",{"id":432,"funder":7,"programme":8,"title":433,"piName":434,"institution":435,"country":143,"year":13,"amount":10,"abstract":436},"openalex-european-research-council-award-erc-poc-2023-ga-101158245-imnovath","Mitochondrial complex I activity promotes antigen cross-presentation in dendritic cells","Sofía C. Khouili","Instituto de Salud Carlos III","Mitochondrial metabolism modulates immune cell signaling, yet how individual electron transport chain complexes fine-tune dendritic cell (DC) function remains unclear. Here, we identify mitochondrial complex I (CI) as a critical metabolic checkpoint controlling antigen cross-presentation by DCs in mice. Deficiency of the CI subunit NDUFS4 in DCs led to the formation of a nonfunctional CI subcomplex, resulting in mildly impaired mitochondrial respiration without triggering a compensatory glycolyt",{"id":438,"funder":7,"programme":8,"title":439,"piName":10,"institution":263,"country":45,"year":13,"amount":14,"abstract":440},"cordis-european-research-council-award-101288730","Polymeric ice nucleators as additives for novel freezing media to improve cryopreservation","Although cryopreservation would allow for the long-term storage of sensitive materials and biological samples, it is not common\npractice because success rates vary greatly between different samples. Improving the success of cryopreservation techniques will\nmake long-term storage more accessible across industries, clinics, and research institutes, enabling more effective use of patient-derived\nmaterials and “back-ups” of crucial cell lines. My ERC-consolidator grant project PROTECT focuses on the",{"id":442,"funder":7,"programme":8,"title":443,"piName":10,"institution":371,"country":12,"year":13,"amount":14,"abstract":444},"cordis-european-research-council-award-101292630","Validating a versatile platform of novel standardized and biobankable preclinical mouse tumor models","Preclinical mouse tumor models are an indispensable experimental tool in cancer research. In turn, they also have limitations since most mouse tumor models do not adequately mimic the course of tumor development as it occurs in humans or the response to therapy. Moreover, there is no standardization of tumor models making it oftentimes difficult to compare the results of different studies. Lastly, animal welfare aspects casts increasing societal doubts about animal experimentation. We have withi",{"id":446,"funder":7,"programme":8,"title":447,"piName":10,"institution":332,"country":20,"year":13,"amount":14,"abstract":448},"cordis-european-research-council-award-101291320","Drone Spin Code: Superscatterer Stickers for Radar Recognition of Drones","Unmanned Aerial Vehicles (UAVs) are poised to revolutionize urban transportation. This implies frequent UAV flights in densely populated areas, offering substantial economic advantages by minimizing ground traffic, automating delivery processes, and enhancing logistic efficiency. The global drone delivery market is projected to reach billions, demonstrating a 49% CAGR from 2022 to 2030. However, this innovation also introduces significant security challenges as the risk of accidents becomes a sa",{"id":450,"funder":7,"programme":8,"title":451,"piName":10,"institution":452,"country":143,"year":13,"amount":14,"abstract":453},"cordis-european-research-council-award-101292605","RNA splicing therapeutics for beta cell dysfunction and diabetes","UNIVERSIDAD POMPEU FABRA","Diabetes is a progressive metabolic disorder driven by beta cell dysfunction and failure, ultimately leading to chronic hyperglycemia and severe clinical complications. Current anti-diabetic treatments, including insulin secretagogues and incretin mimetics, primarily aim to control blood glucose levels without addressing the underlying molecular defects that drive beta cell decline, which in some cases even accelerate their exhaustion. Alternative splicing has recently emerged as a fundamental r",{"id":455,"funder":7,"programme":8,"title":456,"piName":10,"institution":180,"country":45,"year":13,"amount":14,"abstract":457},"cordis-european-research-council-award-101292762","Scalable Brillouin spectrum engineering in thin film lithium niobate","The ERC Proof-of-Concept project, SABER, introduces a paradigm shift in integrated Brillouin photonics by transforming stimulated Brillouin scattering (SBS) from a fixed material property into a software-defined functionality. Co-integrating with high-speed, energy-efficient electro-optic modulators in the thin-film lithium niobate (TFLN) platform, this project will significantly elevate the technology readiness level (TRL) of integrated Brillouin photonics from lab demonstration to system-level",{"id":459,"funder":7,"programme":8,"title":460,"piName":10,"institution":174,"country":175,"year":13,"amount":14,"abstract":461},"cordis-european-research-council-award-101293210","Acoustic Ultrahigh-Q Resonators for Oscillators, Radar, and Applications","Modern communication, sensing, and navigation systems rely on high-performance resonators that define the stability and spectral purity of electronic signals. However, today’s compact acoustic resonators, widely used in wireless infrastructure and consumer electronics, suffer from fundamental limitations in energy loss, frequency stability, and environmental robustness. These constraints prevent their use in emerging technologies that require exceptionally stable and low-noise frequency referenc",{"id":463,"funder":7,"programme":8,"title":464,"piName":10,"institution":465,"country":51,"year":13,"amount":14,"abstract":466},"cordis-european-research-council-award-101293147","VIBRA-Kids: Wearable VIBRation and Audio interface to boost motor and cognitive impairment in children with cerebral palsy","UNIVERSITA DEGLI STUDI DI TORINO","Movements are essential for early development, allowing infants to link proprioceptive feedback with tactile, auditory, and visual inputs. This early multisensory association builds body awareness, spatial cognition, and social interaction. In cerebral palsy (CP), the most common congenital motor disability, affecting 2 to 3 children per 1,000 live births worldwide, this process is disrupted from birth. Without sufficient motor experience, children with CP lack the foundations for multisensory b",{"id":468,"funder":7,"programme":8,"title":469,"piName":10,"institution":225,"country":33,"year":13,"amount":14,"abstract":470},"cordis-european-research-council-award-101293281","Reactor for Upscaling ZEolite Assembly Leveraged On Unique Stirrers","Zeolites are microporous materials consisting of connected silica and alumina tetrahedra. They are key for the production of millions of tons of products as they are considered performance materials in catalysis and separation, guiding the transition to a circular carbon economy. Today, from myriads of possible compositions and combinations of tetrahedra, 270 different zeolite frameworks are documented, yet only about 15 of them are actually applied (or tried in applications) on an industrial (o",{"id":472,"funder":7,"programme":8,"title":473,"piName":10,"institution":474,"country":51,"year":13,"amount":14,"abstract":475},"cordis-european-research-council-award-101286186","SoundHorse: Rhythmicity-based acoustic biomarkers for equine welfare","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","Horses play essential roles in agriculture, sport, therapy, and recreation. The global equine industry is worth over $300 billion annually; just in the US, $1 billion are spent each year on managing lameness—a gait abnormality caused by locomotor disorders. Lameness is a leading cause of injury, premature death, and reduced performance in horses, raising serious animal welfare, economic, and societal concerns. Lameness has also extremely high prevalence, potentially affecting between 30% and 70%",{"id":477,"funder":7,"programme":8,"title":478,"piName":10,"institution":479,"country":101,"year":13,"amount":14,"abstract":480},"cordis-european-research-council-award-101292373","A Wireless Peripheral-Cortical Interface for Real-Time Decoding of Motor Intent to Restore Assistive Control in Tetraplegia (AxonCtrl)","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","Spinal cord injury (SCI) often results in paralysis and the permanent loss of hand and arm function, severely limiting independence and quality of life. Existing assistive technologies, such as surface electromyography, nerve implants, or brain–computer interfaces, are either too inaccurate, too invasive, or too unstable for long-term clinical use. To address this, we have developed intramuscular microelectrode arrays (MEAs) that can be implanted percutaneously to record the discharges of spinal",{"id":482,"funder":7,"programme":8,"title":483,"piName":10,"institution":484,"country":12,"year":13,"amount":14,"abstract":485},"cordis-european-research-council-award-101292445","Frankfurt Research Data Service","JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN","In the digital economy, there is a significant imbalance in access to data. A few major US-based Tech companies, such as Google, Meta, and Amazon, collect large volumes of granular data about consumers, but do not provide much information about this data. Consequently, the European Union reacted. Particularly, the European Digital Markets Act (DMA) forces major Tech companies to provide European consumers access to their data, such as enabling them to export their information. This data covers, ",{"id":487,"funder":7,"programme":8,"title":488,"piName":10,"institution":489,"country":51,"year":13,"amount":14,"abstract":490},"cordis-european-research-council-award-101289383","Origami-Enabled Gripping for Industrial Automation","UNIVERSITA DEGLI STUDI DI TRENTO","FLEXGRIP builds on breakthroughs from the ERC-CoG-funded SFOAM project to introduce a new class of scalable robotic grippers inspired by origami design. Instead of relying on bulky sensors, complex control, or energy-intensive actuators, FLEXGRIP exploits folding kinematics and geometric nonlinearity to adapt seamlessly to objects of different shapes, sizes, and materials. The result is a lightweight, hybrid rigid-soft design that combines the strength and payload of rigid grippers with the deli",{"id":492,"funder":7,"programme":8,"title":493,"piName":10,"institution":494,"country":12,"year":13,"amount":14,"abstract":495},"cordis-european-research-council-award-101292850","Gene therapeutic conversion from APOE4 to APOE3 to prevent Alzheimer’s disease","DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV","The major genetic risk factor for late-onset Alzheimer’s disease (AD) is the presence of the E4 allele of apolipoprotein E (APOE4). APOE is the primary lipid transporter in the brain, mainly expressed by astrocytes, microglia and neurons. There exist three APOE alleles in humans (E2, E3, E4). APOE4 increases the AD risk by 15-fold in homozygous and by 4-fold in heterozygous individuals. The APOE3 is not associated with increased risk and APOE2 is even associated with a reduced AD risk. Thus, new",{"id":497,"funder":7,"programme":8,"title":498,"piName":10,"institution":204,"country":20,"year":13,"amount":14,"abstract":499},"cordis-european-research-council-award-101290805","Light Injection & Collection Apparatus for TEMs:  Facilitating Light-Enhanced Electron Microscopy","Transmission electron microscopy (TEM) is expanding across semiconductor metrology & inspection (M&I) and biological cryo-electron microscopy (cryo-EM), yet both fields share the same bottleneck: insufficient contrast. In cryo-EM, most specimens are weak-phase objects, limiting visualization from single proteins to cells. In M&I, throughput and yield hinge on contrast, especially for 3D reconstructions of next-generation devices.\nComplementary photon pathways help: Collecting light by cathodolum",{"id":501,"funder":7,"programme":8,"title":502,"piName":10,"institution":503,"country":33,"year":13,"amount":14,"abstract":504},"cordis-european-research-council-award-101291903","Time-Domain Boundary Element Analysis and Simulation Toolkit","UNIVERSITEIT GENT","TDBEAST aims to develop a software framework for the time-domain analysis of  transmission in strongly radiating and non-linear systems.\n\nIn emerging technology in communications and imaging, the need arises to model systems that are strongly radiating and non-linear. Because of the non-linearity, modelling needs to be done in the time-domain. Modelling should be free of distortions to the geometry, the introduction of dispersion errors, and the appearance of spurious reflections at the boundary",{"id":506,"funder":7,"programme":8,"title":507,"piName":10,"institution":508,"country":12,"year":13,"amount":14,"abstract":509},"cordis-european-research-council-award-101292827","Digital luminescence for thin-film electron radiation dosimetry","TECHNISCHE UNIVERSITAET DRESDEN","Electron beam (e-beam) irradiation is an extremely versatile tool for many applications that can solve societal challenges in the medical sector or in the circular economy. E-beams are used for example for cancer therapeutics, vaccine development, sterilization, but also for energy saving ink-curing and reprocessing of recycled plastic. In all cases the applied dose, i.e., energy per irradiated mass, is the main process parameter to maintain a certain level of product quality, safety or human he",{"id":511,"funder":7,"programme":8,"title":512,"piName":10,"institution":513,"country":95,"year":13,"amount":14,"abstract":514},"cordis-european-research-council-award-101292974","PersonalAI: Efficient and Private Text Personalization with Large Language Models","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","The rapid adoption of Large Language Models (LLMs) for text generation has created a critical tension between functionality and privacy: while users increasingly rely on services like ChatGPT for personal and business communications, such cloud-based systems require surrendering control of sensitive data to third-party companies, often outside EU jurisdiction. The PersonalAI project addresses this fundamental challenge by enabling fully private, on-device personalization of open-source LLMs, lev",{"id":516,"funder":7,"programme":8,"title":517,"piName":10,"institution":518,"country":89,"year":13,"amount":14,"abstract":519},"cordis-european-research-council-award-101292765","Computer-Aided Drug Design for Bridge-like Lipid Transfer Proteins","UNIVERSITE DE FRIBOURG","Recently, the discovery of a family of large proteins, now called bridge lipid transport proteins (BLTPs), that can act as “bridges” for lipids to flow between organellar membranes, has revolutionized how we think about bulk lipid movement in cells, which was previously thought to take place mainly via vesicular trafficking. These proteins are components of lipid transfer machines that participate in de novo formation of cellular organelles and\u002For in membrane expansion or repair.\nDysfunction in ",{"id":521,"funder":7,"programme":8,"title":522,"piName":10,"institution":523,"country":107,"year":13,"amount":14,"abstract":524},"cordis-european-research-council-award-101289316","Seismic Traffic Awareness","UNIVERSITE GRENOBLE ALPES","\"Road accidents are the eighth-biggest cause of death in the world. In addition to fatalities and irreversible injuries, road accidents incur a large economic impact. In Europe alone, it is estimated that the cost to society of road accidents is €130 billion annually. The main cause of car accidents is speed. It is thus crucial to improve our capacity to detect dangerous driving behaviors and alert in real time.\n\nSAFE (Seismic trAFfic awarEness) will develop a breakthrough, light seismic technol",{"id":526,"funder":7,"programme":8,"title":527,"piName":10,"institution":528,"country":143,"year":13,"amount":14,"abstract":529},"cordis-european-research-council-award-101289202","Massively Scalable Platform for Dual-Mode Discovery of Anti-Amyloid Drugs","FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA","Amyloids are protein aggregates that underlie Alzheimer’s, Parkinson’s, and other devastating diseases, yet effective therapies remain elusive. A key bottleneck is our limited ability to study and target the earliest steps of amyloid formation, which are difficult to probe with existing approaches and poorly suited for large-scale discovery. AMALIA addresses this gap by establishing a dual, massively scalable platform for anti-amyloid drug discovery, combining complementary assays that target ag",{"id":531,"funder":7,"programme":8,"title":532,"piName":10,"institution":533,"country":45,"year":13,"amount":14,"abstract":534},"cordis-european-research-council-award-101293351","Predictive Evaluation of Chemotherapy Resistance by Innovative  Single-molecule Chromatin Signature Examination","ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM","Chemotherapy resistance remains a major obstacle in cancer treatment. In ovarian cancer, up to 50% of patients treated with platinum-based chemotherapy fail to respond yet still experience severe toxicity and disease progression. Biomarkers, like homologous recombination deficiency scores, offer only partial predictive power because resistance often develops through adaptive mechanisms, including replication stress tolerance, secondary mutations, and DNA repair reprogramming, which static geneti",{"id":536,"funder":7,"programme":8,"title":537,"piName":10,"institution":122,"country":51,"year":13,"amount":14,"abstract":538},"cordis-european-research-council-award-101292413","Prenatal Risk Of Toxicity Evaluation for Clinical Translation","Drug safety during pregnancy remains one of the most underexplored and high-risk areas in medicine. \nPregnant women are routinely excluded from clinical trials, and animal models often fail to predict human outcomes, leaving a critical blind spot in assessing fetal drug toxicity. As a result, many therapies are withheld during pregnancy due to insufficient safety data, not demonstrated harm, creating both a medical and societal gap.\nPROTECT proposes the first clinically adaptable, high-throughpu",{"id":540,"funder":7,"programme":8,"title":541,"piName":10,"institution":542,"country":51,"year":13,"amount":14,"abstract":543},"cordis-european-research-council-award-101292653","Tribosynthesis of Carbon Coatings for Friction ad Wear Reduction","ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA","Friction and wear affect all applications involving moving contacts and result in massive economic, energy, and environmental costs. Carbon-based coatings, such as diamond like coatings (DLC), represent an effective solution to mitigate these issues. However, their deposition currently relies on high-temperature processes, which limit their widespread adoption.\nTRIBOSYINC will harness tribochemical reactions, i.e., reactions involving molecules confined at the interface of two bodies under load ",{"id":545,"funder":7,"programme":8,"title":546,"piName":10,"institution":94,"country":95,"year":13,"amount":14,"abstract":547},"cordis-european-research-council-award-101288263","Polar Molecule Quantum Technology","We propose to realize a new type of hybrid quantum technology by coherently coupling a single molecule to a superconducting resonator. This project builds on our group’s pioneering work demonstrating strong coupling of atomic ensembles in cryogenic noble-gas crystals to superconducting circuits. By embedding molecular spins into solid cryogenic matrices placed directly above superconducting devices, we will create a platform that combines long intrinsic coherence, chemical tunability, and seamle",{"id":549,"funder":7,"programme":8,"title":550,"piName":10,"institution":551,"country":143,"year":13,"amount":14,"abstract":552},"cordis-european-research-council-award-101292603","A wearable high-density electromyography system for real-world monitoring and diagnosis of Parkinson’s disease","UNIVERSIDAD DE ZARAGOZA","Parkinson’s disease (PD) affects over 10 million people worldwide and remains one of the most challenging neurological disorders to diagnose and monitor. Current clinical practice relies mainly on subjective evaluations and indirect measures, which limits accurate tracking of disease progression and the development of personalized therapies. There is a clear unmet need for objective, reliable, and user-friendly biomarkers that can be measured in real-world conditions. This Proof of Concept devel",{"id":554,"funder":7,"programme":8,"title":555,"piName":10,"institution":556,"country":557,"year":13,"amount":14,"abstract":558},"cordis-european-research-council-award-101247502","Toward Autonomous Observatories","CENTRUM ASTRONOMICZNE IM. MIKOLAJA KOPERNIKA POLSKIEJ AKADEMII NAUK","PL","Following our first successful results obtained during the ERC Synergy grant, we\npropose to develop a novel software (at the level 6) that allows the simultaneously\noperation of several telescopes and scientific instruments. It will form a firm base for\nfuture autonomous observatories. The software will allow to collect data with higher\nquality and will increase the observing efficiency by 20 – 30%. Therefore, the costs\nof very expensive missions could be reduced by up to 50%.\nThis software will",{"id":560,"funder":7,"programme":8,"title":561,"piName":10,"institution":562,"country":143,"year":13,"amount":14,"abstract":563},"cordis-european-research-council-award-101248666","A single-cell-based solution for an early diagnosis of Richter transformation in patients with chronic lymphocytic leukemia","FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER","Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia in Western countries with an incidence of ~4.6 newly diagnosed cases per 100,000 people per year. Among them, 5-10% of patients with CLL develop Richter transformation (RT), an aggressive transformation of CLL into a high-grade lymphoma, conferring poor outcome. RT is currently the principal unmet medical need in patients with CLL. Thanks to recent findings by our group, we know that there is a time window for early det",{"id":565,"funder":7,"programme":8,"title":566,"piName":10,"institution":106,"country":107,"year":13,"amount":14,"abstract":567},"cordis-european-research-council-award-101292712","Hyperquest – semantic hypergraphs for augmented information retrieval","HyperQuest aims at creating a tool for knowledge extraction from text documents via iterative contextual learning, for use by medium-sized and large companies where these needs are recurrent (automatic document analysis and editing, information retrieval from internal databases, etc.). It aims at overcoming technological barriers by creating intuitive interfaces to help users co-construct complex knowledge extraction and transformation tasks simply and with very few examples, at a level of speci",{"id":569,"funder":7,"programme":8,"title":570,"piName":10,"institution":332,"country":20,"year":13,"amount":14,"abstract":571},"cordis-european-research-council-award-101248381","Harnessing CRISPR-Cas technology for sustainable antibiotic resistance markers","The active spread of antibiotic resistance in laboratories and industry often occurs through the use of plasmids, which transfer resistance genes between bacteria. To mitigate this, strategies such as non-antibiotic selection methods, stringent containment protocols, and plasmid designs that minimize horizontal gene transfer have been proposed. However, these strategies often involve complex methodologies and require highly trained personnel. Recently, our ERC Consolidator results opened the pat",{"id":573,"funder":7,"programme":8,"title":574,"piName":10,"institution":575,"country":101,"year":13,"amount":14,"abstract":576},"cordis-european-research-council-award-101247816","Bioengineering novel post-harvest traits in Brassica crops","THE UNIVERSITY OF EDINBURGH","Food security and nutritious diets for all are major challenges for a rapidly growing global population and for healthy aging. To feed the global population in the coming years, the production of agricultural crops has to sharply increase, yet up to 50% of harvested vegetables are currently wasted along the supply chain from growers to retailers to consumers. Food waste also produces greenhouse gases that contribute to climate change and their diminishing nutrition upon storage compromise health",{"id":578,"funder":7,"programme":8,"title":579,"piName":10,"institution":215,"country":20,"year":13,"amount":14,"abstract":580},"cordis-european-research-council-award-101287454","Three-Phase Topological Superconducting Diode Effect","Quantum computers promise unprecedented computational power, yet the lack of scalable, reliable quantum circuit components remains a major bottleneck to realizing practical quantum processors. A single error in a quantum circuit can corrupt an entire computation, so fault tolerance is essential to truly unlock quantum advantage. Here, topological qubits offer a leading pathway to fault-tolerant quantum computation, but their integration is currently hindered by the lack of essential directional ",{"id":582,"funder":7,"programme":8,"title":583,"piName":10,"institution":283,"country":89,"year":13,"amount":14,"abstract":584},"cordis-european-research-council-award-101248569","Direct Reprogramming for Predictive Nephrotoxicity Testing (DRiPNeT).","Acute tubular necrosis (ATN) is a major cause of nephrotoxicity-related drug attrition in clinical trials, yet current preclinical models rely on animal studies or immortalized renal cell lines, which lack human physiological relevance. To address this gap, we have developed a directly reprogrammed renal epithelial cell (iREC) platform, enabling a human-specific, scalable, and high-throughput nephrotoxicity screening assay.Our iREC-based system overcomes the limitations of primary, or iPSC-deriv",{"id":586,"funder":7,"programme":8,"title":587,"piName":10,"institution":588,"country":12,"year":13,"amount":14,"abstract":589},"cordis-european-research-council-award-101248723","Preclinical Development of Personalized Functional Markers for Deep Brain Stimulation","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","Deep brain stimulation (DBS) is used to treat neurological and neuropsychiatric disorders. To date, DBS devices have been implanted in more than 300,000 patients worldwide. However, the efficacy of DBS therapy varies across patients, leaving a substantial number of patients without significant symptom alleviation. Optimizing therapeutic outcomes is highly desirable for the patients’ well-being as well as to reduce socio-economic burden of untreated disorders. One of the major impeding obstacles ",{"id":591,"funder":7,"programme":8,"title":592,"piName":10,"institution":593,"country":12,"year":13,"amount":14,"abstract":594},"cordis-european-research-council-award-101248578","Design of Flow-Photoelectrolyzer","GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS","The EU strongly strives for a sustainability transformation, and the EU Commission's Green Deal accelerates climate neutrality by 2050, with a modern and competitive economy. Climate neutrality of the chemical industries calls for innovative resource- and energy-economical technologies to harvest renewable forms of energy and prevent chemical waste. Breakthrough studies demonstrated the unique potential of harnessing both solar and electrical energy for sustainable syntheses. Thereby, chemical w",{"id":596,"funder":7,"programme":8,"title":597,"piName":10,"institution":593,"country":12,"year":13,"amount":14,"abstract":598},"cordis-european-research-council-award-101247478","Biomedical Image Quantification by a Scalable and Open Cloud Solution","BiQ-Cloud (Biomedical Image Quantification Cloud) is a groundbreaking cloud-based platform designed to revolutionize biomedical research by providing scalable, cost-effective, and cutting-edge image analysis tools. Current solutions are often either costly and outdated or require specialized IT skills, thereby limiting access for many users, including researchers, small and mid-sized companies, as well as large-scale organizations. BiQ-Cloud overcomes these barriers by offering a flexible platfo",{"id":600,"funder":7,"programme":8,"title":601,"piName":10,"institution":602,"country":89,"year":13,"amount":14,"abstract":603},"cordis-european-research-council-award-101248581","Integrated Novel Bypass Element Enabling Stable Perovskite Solar Cells and Modules for Mass Production","ZURCHER HOCHSCHULE FUR ANGEWANDTE WISSENSCHAFTEN","The European Green Deal aims for a climate neutral EU in 2050. This can only be achieved by novel technologies, amongst them renewable energy sources. Photovoltaics has proven viable but requires improvements in terms of its environmental footprint. Thus, efficiency must be maximized and energy and raw materials used for production minimized. The recently emerged research field of perovskite solar cells (PSCs) might provide an answer to these challenges. However, PSCs face one huge obstacle on t",{"id":605,"funder":7,"programme":8,"title":606,"piName":10,"institution":215,"country":20,"year":13,"amount":14,"abstract":607},"cordis-european-research-council-award-101268383","A peptide targeting p21-CDK4 interaction for treatment of pulmonary fibrosis","Pulmonary fibrosis is an age-related disease characterized by progressive scarring of lung tissue, loss of respiratory function, and premature death. It is a fatal disease, affecting roughly ~5 million worldwide and causing >17.000 annual deaths in Europe alone. There is no cure for pulmonary fibrosis, as current treatments modestly slow disease progression but do not reverse fibrosis or substantially improve survival. These therapies often carry significant side effects and fail to address the ",{"id":609,"funder":7,"programme":8,"title":610,"piName":10,"institution":588,"country":12,"year":13,"amount":14,"abstract":611},"cordis-european-research-council-award-101292651","Synthesis of Certifiable Control Software for Lane Change in Autonomous Vehicles","Autonomous driving keeps advancing, yet one obstacle persists: building lane-level behaviors whose software is provably safe. In current practice, requirements are written in natural language, interpreted inconsistently, and implemented with ad-hoc heuristics. Human error and limited test coverage leave edge cases unaddressed, while mileage-heavy validation is slow and costly. The result is fragile behavior and eroded public trust. Building on our research project AutoCPS, we will turn correct-b",{"id":613,"funder":7,"programme":8,"title":614,"piName":10,"institution":503,"country":33,"year":13,"amount":14,"abstract":615},"cordis-european-research-council-award-101248566","Breakthrough industry grade tagging of plastic products","BIGTOP aims to bring a groundbreaking molecular tagging technology for plastic materials closer to the market by making use of sequence-defined oligomers developed under the ERC advanced grant CiMaC project. These molecular tags, which encode information using precise monomer sequences, offer a powerful solution for product traceability, anti-counterfeiting, and origin identification across industries. Thanks to the research in CiMaC, we have already demonstrated the scalable synthesis and high ",{"id":617,"funder":7,"programme":8,"title":618,"piName":10,"institution":619,"country":143,"year":13,"amount":14,"abstract":620},"cordis-european-research-council-award-101248669","Tandem Electrodeless Plasma Thrusters for Universal and Versatile in-Space Propulsion","UNIVERSIDAD CARLOS III DE MADRID","Highly versatile and easy-to-integrate space propulsion will unlock a new stage of the conquest and exploitation of space. NEPTUNE aims to assess the innovation potential of the ‘Magnetic Arch Tandem’ (MAT) thruster concept, which consists in pairing two electrodeless plasma sources to form an innovative closed magnetic topology for plasma jet acceleration. The MAT can operate with any propellant gas; it is simple, durable, and promises a wide operational envelope; has zero net magnetic dipole, ",{"id":622,"funder":7,"programme":8,"title":623,"piName":10,"institution":429,"country":12,"year":13,"amount":14,"abstract":624},"cordis-european-research-council-award-101292092","AutoML Co-Designer: A Collaborative Framework for Accelerated AI Development","The growth of the AI market depends on our ability to rapidly and efficiently develop robust AI applications, for which AI developers can be supported by Automated Machine Learning (AutoML), e.g., in model selection, neural network design, or hyperparameter settings. However, current AutoML systems are designed as rigid 'black boxes' and thus create a critical bottleneck. They sideline expert developers, preventing the integration of crucial domain knowledge. This inflexibility slows down develo",{"id":626,"funder":7,"programme":8,"title":627,"piName":10,"institution":337,"country":89,"year":13,"amount":14,"abstract":628},"cordis-european-research-council-award-101248663","Selective isolation of biopharmaceuticals with fluid zwitterionic polymeric coacervates","Gene therapy and RNA-based therapeutics hold significant promise for treating a range of debilitating disorders. A key challenge for these therapies is the effective targeted delivery, which relies on nanovehicles to ensure the stability of the delicate nucleic acids involved. Biogenic nanoparticles, such as adeno-associated viruses (AAVs), are becoming increasingly promising for these applications, with some AAV-based therapies already receiving regulatory approval. However, maintaining the phy",{"id":630,"funder":7,"programme":8,"title":631,"piName":10,"institution":632,"country":73,"year":13,"amount":14,"abstract":633},"cordis-european-research-council-award-101267309","Targeting GAB1: a novel therapeutic strategy for the treatment of leukemias","Masarykova univerzita","The emergence of therapy resistance and adaptation in acute myeloid leukemia (AML) remains a major challenge, leading to treatment failure and mortality. We and others have provided experimental evidence supporting novel idea that adaptation and resistance to therapy could be in early stages driven by signaling pathway rewiring, rather than genetic mutations. This project aims to advance our novel GAB1 inhibitors, targeting the adaptor protein GAB1- a key regulator of multiple signaling pathways",{"id":635,"funder":7,"programme":8,"title":636,"piName":10,"institution":637,"country":12,"year":13,"amount":14,"abstract":638},"cordis-european-research-council-award-101289150","Ultra-Fast Brillouin Light-Sheet Microscopy for Real-Time Mechanical Imaging in Biology","EUROPEAN MOLECULAR BIOLOGY LABORATORY","Understanding the mechanical properties of biological systems is crucial for unraveling key processes in development, disease progression, and cellular function. This ERC Proof-of-Concept project proposes the development of a next-generation Brillouin microscope, inspired by light-sheet microscopy principles, to enable ultra-fast, high-resolution, and label-free imaging of mechanical properties in live biological samples. Traditional Brillouin microscopy has been limited by slow acquisition spee",{"id":640,"funder":7,"programme":8,"title":641,"piName":10,"institution":230,"country":231,"year":13,"amount":14,"abstract":642},"cordis-european-research-council-award-101247183","Investigating the potential of microbiome-derived amyloidogenic proteins as clinical biomarkers for the early detection of Parkinson’s disease","Parkinson’s disease (PD) is a debilitating neurodegenerative disorder affecting over 6 million individuals worldwide, with its prevalence projected to double by 2040. Early detection of PD represents a critical unmet clinical need, as current diagnostics are limited to detecting motor symptoms after extensive neuronal damage has already occurred. My ERC Consolidator Grant ExpoBiome has uncovered specific microbiome-derived molecules as potential biomarkers linked to PD pathology. These proteins,",{"id":644,"funder":7,"programme":8,"title":645,"piName":10,"institution":332,"country":20,"year":13,"amount":14,"abstract":646},"cordis-european-research-council-award-101287796","Peptide-based Robust and Innovative Molecular Condensate Engineering for Antibody-Drug Conjugates","Antibody drug conjugates are among the most promising targeted cancer therapies, combining the specificity of monoclonal antibodies with the potency of cytotoxic drugs. Yet, more than 80% of ADC candidates fail to progress beyond early clinical stages. A key reason lies in current conjugation chemistries: lysine- and cysteine-based methods yield heterogeneous products with unstable linkages, poor pharmacokinetics, and high manufacturing inefficiencies, wasting up to 50% of material. Copper-catal",{"id":648,"funder":7,"programme":8,"title":649,"piName":10,"institution":650,"country":557,"year":13,"amount":14,"abstract":651},"cordis-european-research-council-award-101212992","Improving cancer therapy by identification of novel drug leads modulating transcription termination bridging molecular biology and therapeutic applications","UNIWERSYTET IM. ADAMA MICKIEWICZA WPOZNANIU","Our value proposition is improving cancer therapy by identification of novel anti-cancer candidate drug leads modulating transcription termination, bridging molecular cancer biology and therapeutic applications.We have developed a methodology to directly measure alterations in transcription termination and successfully subjected it to miniaturization and automatization processes. We are applying for funding to validate a screening platform to identify small molecule inhibitors of transcription t",{"id":653,"funder":7,"programme":8,"title":654,"piName":10,"institution":655,"country":143,"year":13,"amount":14,"abstract":656},"cordis-european-research-council-award-101248041","PEPtide-based Therapy for recurrent Ovarian Cancer","UNIVERSIDADE DA CORUNA","Ovarian cancer recurrence after complete clinical response is a major challenge in gynecologic oncology. Recurrence occurs in nearly 25% of early-stage cases and in more than 80% of advanced-stage cases. Current targeted therapies for the treatment of ovarian cancer relapse are still in Phase II clinical trials and, while these therapies represent significant advances in cancer treatment, they target broad inhibitory mechanisms that affect DNA repair and signaling pathways in a variety of cell t",{"id":658,"funder":7,"programme":8,"title":659,"piName":10,"institution":660,"country":143,"year":13,"amount":14,"abstract":661},"cordis-european-research-council-award-101248584","Harness lncRNA targeting to treat colorectal cancer","FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA","Colorectal cancer (CRC) is the third leading cause of cancer-related death globally. Despite the therapeutic advances, innate and acquired resistance is still an adversity that needs to be overcome. Therefore, there is an urgent need to identify more targeted and specific therapeutic approaches in order to increase success of the treatment and reduce the medical and economic burden of therapeutic failures. Numerous studies have been conducted to target the replication stress response, a hallmark",{"id":663,"funder":7,"programme":8,"title":664,"piName":10,"institution":528,"country":143,"year":13,"amount":14,"abstract":665},"cordis-european-research-council-award-101291716","Cellular Analysis with Multi-Sample MRI Platform","CAMP project seeks to translate the hyperpolarisation-enhanced magnetic resonance metabolic imaging platform, developed under the ERC-funded project Lifetime Metabolomics for Paediatric Liver Cancer Detection and Therapy Assessment Using Organ-on-Chip Platforms (LIFETIME), into a commercially viable solution for multi-sample metabolic analysis. This Proof of Concept (PoC) grant will focus on validating the platform's commercial viability, technical feasibility and IP positioning, with the ultima",{"id":667,"funder":7,"programme":8,"title":668,"piName":10,"institution":669,"country":12,"year":13,"amount":14,"abstract":670},"cordis-european-research-council-award-101293194","Optimizing Immune Checkpoint Inhibitor Payloads for Oncolytic Virus-Based Immunotherapy","KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)","Despite novel innovations in immune-oncology over the last decades, up to 80% of solid cancers remain unresponsive to currently available approaches, highlighting an urgent unmet clinical need. CHECKVIR aims to develop and validate a next-generation oncolytic virus-based immunotherapy approach to overcome treatment resistance in solid cancers. The technology leverages an optimized oncolytic virus platform that is engineered to elicit immune checkpoint inhibitory functions, thereby combining effi",{"id":672,"funder":7,"programme":8,"title":673,"piName":10,"institution":32,"country":33,"year":13,"amount":14,"abstract":674},"cordis-european-research-council-award-101286594","Secondary-Electron Imaging through Electron-Beam-Induced Current: a Fast and Easy Approach for 3-Dimensional Characterisation of Nanoparticles","The properties of nanomaterials are essentially determined by their size and three-dimensional (3D) structure, typically assessed by Electron Microscopy (EM) techniques such as Scanning Electron Microscopy or Electron Tomography. Unfortunately, the spatial resolution of SEM is limited and ET suffers from low temporal resolution. Here, we present an alternative approach “Secondary-Electron Electron-Beam-Induced Current (SEEBIC)”, a technique during which a dedicated Transmission Electron Microsco",{"id":676,"funder":7,"programme":8,"title":677,"piName":10,"institution":678,"country":101,"year":13,"amount":14,"abstract":679},"cordis-european-research-council-award-101248565","Pixelated polariton filters for multichannel hyperspectral lensless imagers","THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS","Fluorescence microscopy is a fundamental tool in biomedical research, pharmaceutical development, and clinical diagnostics, yet conventional systems remain costly, bulky, and impractical for scalable or portable applications. PolaritonPixels introduces a lensless multicolour fluorescence imaging platform that integrates arrays of narrow-band polariton filters directly onto CMOS imaging chips, eliminating the need for traditional bulky optics and filter wheels. This breakthrough enables simultane",{"id":681,"funder":7,"programme":8,"title":682,"piName":10,"institution":66,"country":67,"year":13,"amount":14,"abstract":683},"cordis-european-research-council-award-101248733","Integrating Quality Monitoring into 3D Bioprinting via Light Sheet Microscopy","A critical bottleneck in bioprinting hardware is the lack of integrated quality monitoring features for characterising print accuracy and cellular composition during fabrication. This limitation makes it challenging to develop reproducible and standardised bioprinting protocols, which are essential for GMP-compliant production. The lack of integrated quality monitoring also leads to a reliance on destructive, post-printing analysis methods that are incompatible with clinical translation. To addr",{"id":685,"funder":7,"programme":8,"title":686,"piName":10,"institution":687,"country":12,"year":13,"amount":14,"abstract":688},"cordis-european-research-council-award-101248573","Scalable Photon-Number-Resolving Integrated Cryogenic Electronics","UNIVERSITAET PADERBORN","Large-scale configurations of superconducting nanowire single-photon detectors (SNSPDs) are essential for quantum technologies such a photonic quantum computing, quantum communication and quantum sensing. Furthermore, spatial arrays of SNSPDs are ideally suited to light-starved applications such as deep-space optical communication (DSOC), single-photon imaging, microscopy, and spectroscopy. While SNSPDs offer near-unity efficiency, high timing resolution, and low noise, their potential is constr",{"id":690,"funder":7,"programme":8,"title":691,"piName":10,"institution":337,"country":89,"year":13,"amount":14,"abstract":692},"cordis-european-research-council-award-101248155","Refractive Index Observer","Microscale chemical gradients are essential in life sciences, materials science, and chemical processes, yet existing measurement methods rely on fluorophores or dyes that inherently alter system properties and provide only indirect insights.With this PoC, we aim to revolutionize their quantification by further developing and ultimately commercializing RIO - the Refractive Index Observer - an add-on device for optical microscopes that enables label-free, high-resolution characterization of chemi",{"id":694,"funder":7,"programme":8,"title":695,"piName":10,"institution":696,"country":39,"year":13,"amount":14,"abstract":697},"cordis-european-research-council-award-101248556","Virtual Reality (VR) in your suitcase: Lowering the entry point to VR adoption for immersive planning of urban street interventions.","HELSINGIN YLIOPISTO","We aim at creating a Proof of Concept for an Urban Immersive Street Environment intervention VR Package (UrbanISE VR) that converts our existing research VR environment, developed through the GREENTRAVEL Project, into a portable VR-in-a-suitcase solution. The UrbanISE VR solution will support easy implementation and testing of various street intervention plans in an immersive and realistic VR environment, which allows the user to move through alternative street designs in different seasons and w",{"id":699,"funder":7,"programme":8,"title":700,"piName":10,"institution":701,"country":143,"year":13,"amount":14,"abstract":702},"cordis-european-research-council-award-101287353","THIckness determination via COHERENt TERAhertz detection","FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA","What better way to measure thin films than by using a material that is just one atom thick?Society requires materials in user products and infrastructure to function properly, which requires quality control through non-destructive testing, ideally without physical contacts. One particularly important quality test is the thickness determination of thin films, such as car paint, coatings of wind turbines, and different material layers in chips. Low-energy (sub)terahertz light offers several benefi",{"id":704,"funder":7,"programme":8,"title":705,"piName":10,"institution":706,"country":45,"year":13,"amount":14,"abstract":707},"cordis-european-research-council-award-101292398","Quantum superlattices for scalable SWIR photodetectors","RIJKSUNIVERSITEIT GRONINGEN","QUASAR aims to demonstrate the feasibility of a new class of short-wave infrared (SWIR) photodetectors based on three-dimensional (3D) quantum dot superlattices, developed from foundational research carried out under the ERC Advanced Grant “Design and Engineering of Optoelectronic Metamaterials” (DEOM). Building on recent breakthroughs in solution-processed materials and large-area superlattice assembly, the project targets the fabrication of retina-safe SWIR detectors with high detectivity (≥10",{"id":709,"funder":7,"programme":8,"title":710,"piName":10,"institution":706,"country":45,"year":13,"amount":14,"abstract":711},"cordis-european-research-council-award-101248563","Ferroelectric Leaky Integration for Computational Efficiency","The rapid growth of AI demands efficient hardware solutions that enable real-time learning and decision-making in power-constrained edge applications, such as autonomous systems, medical diagnostics, and industrial monitoring. However, current AI hardware faces fundamental trade-offs between power consumption, processing efficiency, and accuracy, limiting its deployment at the edge. Traditional computing architectures separate memory and processing, leading to high energy costs associated with d",{"id":713,"funder":7,"programme":8,"title":714,"piName":10,"institution":715,"country":12,"year":13,"amount":14,"abstract":716},"cordis-european-research-council-award-101248568","Saving vision: expanding use of lentiviral gene therapy to fight blindness","MEDIZINISCHE HOCHSCHULE HANNOVER","Sight is the most treasured of our senses, followed by hearing and balance. Moderate to severe vision loss affects more than 216 million people worldwide, with an estimated 36 million people suffering from blindness. Monogenic diseases caused by mutations in genes such as MYO7A are responsible for vision loss in over two million people. As current treatment options for genetic vision loss are limited or non-existent, there is a high clinical need for innovative approaches, such as gene therapy. ",{"id":718,"funder":7,"programme":8,"title":719,"piName":10,"institution":720,"country":20,"year":13,"amount":14,"abstract":721},"cordis-european-research-council-award-101248639","Next-Gen Targeted Protein Degradation: Directing Disease Proteins to the Proteasome","BAR ILAN UNIVERSITY","The ubiquitin-proteasome system (UPS) is crucial for maintaining diverse cellular functions through the selective degradation of proteins. Targeted Protein Degradation (TPD) has emerged as an innovative therapeutic strategy that harnesses the UPS to selectively degrade disease-causing proteins. A major advancement in TPD is the use of proteolysis-targeting chimeras (PROTACs), small molecules that bind both an E3 ligase (E3) and the target protein, to induce ubiquitination and subsequent degradat",{"id":723,"funder":7,"programme":8,"title":724,"piName":10,"institution":593,"country":12,"year":13,"amount":14,"abstract":725},"cordis-european-research-council-award-101247621","Plasmonic microchip for absolute and calibration-free  luminescence quantum yield measurements","Quantum yield of luminescence is a critical parameter in both scientific research and industrial applications, providing essential insight into the efficiency of various photophysical and photochemical processes. It represents the ratio of photons emitted to photons absorbed by a substance, typically in the context of fluorescence, phosphorescence, or photochemical reactions. Accurate quantum yield measurements are essential for assessing the performance of molecules, materials, and devices acro",{"id":727,"funder":7,"programme":8,"title":728,"piName":10,"institution":729,"country":51,"year":13,"amount":14,"abstract":730},"cordis-european-research-council-award-101286935","BrightMind: An Integrated Hardware-Software Platform for Smart Photon Resolved Microscopy","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","Fluorescence laser-scanning microscopy (LSM) is the workhorse of life-science research, enabling low-invasive methods to probe live-cells with molecular sensitivity and high spatiotemporal resolution. Its impact has recently been expanded by photon-resolved microscopy, which uses single-photon array detectors to record photons one-by-one with precise spatial, temporal and spectral signatures. Analysis of this dataset yields unprecedented information, such as sub-diffraction images (down to the m",{"id":732,"funder":7,"programme":8,"title":733,"piName":10,"institution":729,"country":51,"year":13,"amount":14,"abstract":734},"cordis-european-research-council-award-101287230","Edible technology for the Autonomous Tracking of gastrointestinal health","EAT will demonstrate the first Proof-of-Concept (PoC) of a fully edible smart pill for safe, accessible, and autonomous monitoring of gastrointestinal (GI) physiology. GI, metabolic, and nutritional disorders represent a growing global challenge, with high prevalence, rising healthcare costs, and major impact on quality of life. Breakthroughs in their prevention and timely treatment require continuous monitoring of GI physiology, but suitable tools are still missing. Available ingestible technol",{"id":736,"funder":7,"programme":8,"title":737,"piName":10,"institution":619,"country":143,"year":13,"amount":14,"abstract":738},"cordis-european-research-council-award-101292611","Real-time data-driven flow diagnostics with event-based cameras","Experiments in fluid dynamics remain an expensive bottleneck for designing, improving and benchmarking new solutions. Pointwise probes provide either sparse information, or only statistics for the full field. Optical measurement techniques deliver instantaneous flow fields, but at the expense of high data volumes, complex and costly instrumentation, and delayed feedback. RT-FLOW will demonstrate a compact, event-based imaging velocimetry system enhanced by data-driven techniques, enabling real-t",{"id":740,"funder":7,"programme":8,"title":741,"piName":10,"institution":706,"country":45,"year":13,"amount":14,"abstract":742},"cordis-european-research-council-award-101248560","Safer intravenous infusion therapy enabled by aerosol jet printed non-contact ultrasensitive flow sensors","Intravenous (IV) infusion therapy is a widely used procedure in hospitals, with over a billion infusions administered annually globally. Despite its prevalence, IV infusions pose significant risks, with up to 60% experiencing incorrect flow rates, leading to adverse events for vulnerable patient groups such as preterm babies and critically ill individuals. To solve this problem, we developed a patented innovative aerosol jet printed micro-electromechanical-systems (MEMS) flow monitoring technolo",{"id":744,"funder":7,"programme":8,"title":745,"piName":10,"institution":225,"country":33,"year":13,"amount":14,"abstract":746},"cordis-european-research-council-award-101248534","Sustainable Thermoelectric Generators for Low-Power Applications","The Internet of Things (IoT), where everyday objects sense their environment and communicate with each other, is a key drive of digitalization expected to make our society safer, more sustainable, and more competitive. The full deployment of the IoT requires sustainable and long-lasting energy solutions to minimize e-waste. Thermoelectrics (TEs) can convert the ubiquitous waste heat into electricity and could complement or even replace batteries to meet the renewable energy needs of IoT nodes. H",{"id":748,"funder":7,"programme":8,"title":749,"piName":10,"institution":94,"country":95,"year":13,"amount":14,"abstract":750},"cordis-european-research-council-award-101248099","Collaborative Robots for Impact-based Manipulation","The CORIM project aims to introduce a technology that has the potential to significantly expand the application area of collaborative robots (cobots) in the manufacturing sector. Today's collaborative robots have limited ability to handle tasks that require rapid contact transitions with stiff environments, since the force peaks emerging from the contact transition endanger key elements such as gears and force sensors in the collaborative robots. Based on findings of the ERC project NatDyReL, we",{"id":752,"funder":7,"programme":8,"title":753,"piName":10,"institution":122,"country":51,"year":13,"amount":14,"abstract":754},"cordis-european-research-council-award-101292636","High-Q metasurface sensor for rapid on-site PFAS quantification in water","Per- and polyfluoroalkyl substances (PFAS) are synthetic, bio-accumulative chemicals extensively used in industrial and consumer applications. Their extreme persistence has led to widespread, uncontrolled presence in water, soil, and even human blood. Proven links of PFAS to serious health effects, including cancer, immune dysfunction, and reproductive toxicity, have prompted increasingly strict regulations from the U.S. Environmental Protection Agency and the European Chemicals Agency. Growing ",{"id":756,"funder":7,"programme":8,"title":757,"piName":10,"institution":209,"country":210,"year":13,"amount":14,"abstract":758},"cordis-european-research-council-award-101247218","Porous sensors for real-time monitoring of water quality risks","The unpredictable contamination of microbial communities in aquatic environments is a global concern for drinking water suppliers and aquaculture producers. Drinking water treatment expenditures, mainly caused by excessive proliferation of harmful cyanobacteria can cost over €150 million\u002Fyear in European countries. The scenario aggravates when considering the debilitating attacks from pathogenic bacteria in aquaculture cages, generating global economic losses of over $25 billion. In both industr",{"id":760,"funder":7,"programme":8,"title":761,"piName":10,"institution":762,"country":51,"year":13,"amount":14,"abstract":763},"cordis-european-research-council-award-101247603","Enhanced Platform for the Identification of molecules Boosting or Limiting Amniotic cavity and primitive STreak formation","UNIVERSITA DEGLI STUDI DI PADOVA","Drug teratogenicity, namely the potential of a drug to cause birth defects, is a major concern for anyone becoming pregnant. The infamous Thalidomide case in the 1960s raised public awareness of this issue. Notably, only about 30% of embryos successfully implant during early development, but the reasons for this low rate remain unclear. Nobody knows if this is due to the teratogenic effects of common drugs, or a lack of essential nutrients needed for development, similar to how folate is used to",{"id":765,"funder":7,"programme":8,"title":766,"piName":10,"institution":767,"country":143,"year":13,"amount":14,"abstract":768},"cordis-european-research-council-award-101247157","Electricity market Hawkeye - An online surveillance tool to detect distortions in the supply-side of electricity markets","UNIVERSIDAD DE MALAGA","While electricity is a basic commodity that underpins industrialization, progress and the quality of life of human beings, its production, storage and transmission is strongly constrained by physical laws and its demand is utterly inelastic. All of this together exacerbates the vulnerability of a sector that is vital to modern societies. A critical and vulnerable sector is not only easily affected by external supply shocks, but also susceptible to manipulation and abuse. Spurred by the convictio",{"id":770,"funder":7,"programme":8,"title":771,"piName":10,"institution":245,"country":149,"year":13,"amount":14,"abstract":772},"cordis-european-research-council-award-101248667","Power System Simulator based on Physics-Informed Neural Networks","This proposal puts forward a first-of-its-kind power system dynamics simulator based on neural networks: PINNSim. PINNSim aims to deliver a highly modular and scalable tool that can be up to 100x faster than any commercial power system simulator. This means that PINNSim can perform a power system stability assessment in 30 minutes instead of 2 days. We witness a dramatic shift from few large scale generators to millions of converter-based resources, such as solar, wind, batteries, and electric v",{"id":774,"funder":7,"programme":8,"title":775,"piName":10,"institution":776,"country":12,"year":13,"amount":14,"abstract":777},"cordis-european-research-council-award-101293333","Photonic-chip based ultralow-noise microwaves","DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY","Microwave oscillators are essential for a variety of technologies, including mobile communications, radar, navigation, and data networks. However, current compact solutions, such as voltage-controlled oscillators, face fundamental noise limits. Although laboratory-scale optical approaches can achieve significantly improved performance, they often require bulky, power-hungry, and costly systems. pureWAVE aims to address this issue by implementing low-noise photonic oscillators on a scalable chip ",{"id":779,"funder":7,"programme":8,"title":780,"piName":10,"institution":781,"country":782,"year":13,"amount":14,"abstract":783},"cordis-european-research-council-award-101241675","Quantum Annealing for Fluid Antenna MIMO Systems","UNIVERSITY OF CYPRUS","CY","Multiple-input multiple-output (MIMO) technology transformed wireless communications. However, the extreme requirements of the envisioned 6G services and the highly complex and dynamic radio environments of next-generation wireless networks call for better exploitation of the spatial channel dynamics and adaptation to rapid channel variations. Fluid antenna systems (FAS) have been recently proposed in response to these issues. They leverage liquid antennas whose position can be adjusted in real-",{"id":785,"funder":7,"programme":8,"title":786,"piName":10,"institution":787,"country":89,"year":13,"amount":14,"abstract":788},"cordis-european-research-council-award-101248440","REprogramming Pancreatic Alpha-cells for Insulin production Restoration in diabetes","UNIVERSITE DE GENEVE","Diabetes affects some 500 million people worldwide (estimated 700 million by 2045), causing over one million deaths annually. The disease results from the loss \u002F dysfunction of pancreatic islet insulin-producing β-cells, leading to chronic hyperglycemia and severe complications. Current treatments are symptomatic and fail to restore long-term glucose regulation, stressing the need for a transformative curative approach.Our proposal leverages α-cell reprogramming as a novel therapy for the restor",{"id":790,"funder":7,"programme":8,"title":791,"piName":10,"institution":159,"country":45,"year":13,"amount":14,"abstract":792},"cordis-european-research-council-award-101247730","Highly functional and chemically defined hybrid supramolecular hydrogels for organoid culture and multi-technology bioprinting (HYBRIGEL)","There is a growing need for reproducible, human-relevant in vitro models to advance biomedical research and drug discovery. Current 3D culture systems often fail to replicate the complexity of native tissues, contributing to poor clinical translation rates and limiting the development of animal-free testing platforms. While organoid technologies and biofabrication methods offer promising solutions, their progress is constrained by the lack of standardized, scalable biomaterials. Widely used matr",{"id":794,"funder":7,"programme":8,"title":795,"piName":10,"institution":489,"country":51,"year":13,"amount":14,"abstract":796},"cordis-european-research-council-award-101213402","High-precision eye-tracking in nonvisual settings","In the rapidly evolving landscape of cognitive neuroscience, a significant surge in research has highlighted eye movements as a critical yet previously underestimated window into neuro-cognitive processes. Our project is at the forefront of this paradigm shift, proposing an innovative machine learning-based approach to decode eye movements with high precision using electrooculography (EOG) channels alone. This method is set to revolutionize eye-tracking technologies, particularly in non-visual c",{"id":798,"funder":7,"programme":8,"title":799,"piName":10,"institution":800,"country":107,"year":13,"amount":14,"abstract":801},"cordis-european-research-council-award-101247532","Virtual Reality and AI for Real-Time Clinical Decision Support  and Intracranial Aneurysm Risk Prediction","ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS","Intracranial aneurysms (IAs) pose a severe neurovascular threat, with rupture leading toIntracranial aneurysms (IAs) pose a severe neurovascular threat, with rupture leading to life-threatening complications. Current treatment planning relies on static imaging and computational fluid dynamics, which are computationally expensive and lack real-time clinical integration. Clinicians face uncertainty in selecting optimal intervention strategies, increasing procedural risks and costs. VRAI-CURE propo",{"id":803,"funder":7,"programme":8,"title":804,"piName":10,"institution":805,"country":45,"year":13,"amount":14,"abstract":806},"cordis-european-research-council-award-101292927","Cardiac Uptake REstoration of Glucose in diabetic Heart Failure","ACADEMISCH ZIEKENHUIS GRONINGEN","Heart failure (HF) affects over 64 million people worldwide and is a leading cause of hospitalization and premature death. About 40% of HF patients also have type 2 diabetes, doubling mortality risk. In HF, the stressed myocardium shifts toward glucose metabolism, but in diabetes cardiomyocytes fail to take up glucose and remain reliant on fatty acids, leaving the heart energy-starved. Current HF therapies target neurohormonal pathways to reduce workload and slow progression but do not address t",{"id":808,"funder":7,"programme":8,"title":809,"piName":10,"institution":810,"country":39,"year":13,"amount":14,"abstract":811},"cordis-european-research-council-award-101248648","Waveform-based prediction of AD-related pathology for patient diagnostics (WAVEAD)","ITA-SUOMEN YLIOPISTO","Due to the early AD-related pathology present in a subpopulation of idiopathic normal pressure hydrocephalus (iNPH) patients, the brains of the iNPH patients offer a unique window to evaluate events taking place during the course of AD pathology progression. Here we take advantage of our continuous access to living brain biopsies from iNPH patients and related clinical data to assess, how AD pathology affects the neuronal circuit operational properties in human brain. During the ERC consolidator",{"id":813,"funder":7,"programme":8,"title":814,"piName":10,"institution":815,"country":101,"year":13,"amount":14,"abstract":816},"cordis-european-research-council-award-101247164","360° View Control by Eye Movement for Extended Reality","UNIVERSITY OF LANCASTER","Virtual\u002Fextended reality (VR\u002FXR) head-mounted displays (HMDs) provide users with a portal to virtually infinite display space that extends all around them. This has the potential to revolutionise work, learning and leisure activities as users can enter personalised spaces from anywhere via their HMD to access 3D data, views and apps all around in 360°. However, full use of the surrounding space is only possible with extensive head and body movement as HMDs are head-coupled – prohibiting access i",{"id":818,"funder":7,"programme":8,"title":819,"piName":10,"institution":820,"country":12,"year":13,"amount":14,"abstract":821},"cordis-european-research-council-award-101287951","High-Speed Vapour Deposition of Metal Halide Perovskites  for Scalable Applications","LEIBNIZ INSTITUT FUR FESTKORPER UND WERKSTOFFORSCHUNG DRESDEN EV","Metal halide perovskite solar cells have rapidly progressed from a research breakthrough to a commercially viable technology, recently making their market debut. Their excellent performance and cost-effectiveness make them strong contenders for next-generation photovoltaic applications, especially when paired with traditional silicon in tandem configurations. However, scaling up for widespread deployment requires manufacturing approaches compatible with industrial needs. Vapour phase deposition ",{"id":823,"funder":7,"programme":8,"title":824,"piName":10,"institution":825,"country":12,"year":13,"amount":14,"abstract":826},"cordis-european-research-council-award-101293326","Intralaser-enhanced Broadband Terahertz Spectrometer","RUHR-UNIVERSITAET BOCHUM","The terahertz frequency region (ca. 300 GHz to 30 THz) is gaining in popularity across a wide range of fields, with different technologies being deployed in commercial systems and industrial applications. One of the largest and fastest growing markets for THz technologies are imaging systems for non-destructive testing. Among the multiple technologies advancing this frequency region and application, ultrafast laser-driven broadband THz time-domain spectrometers (THz-TDS) offer several unique adv",{"id":828,"funder":7,"programme":8,"title":829,"piName":10,"institution":419,"country":12,"year":13,"amount":14,"abstract":830},"cordis-european-research-council-award-101287293","FortifyNet: An Automated Tool for Fortifying Communication Networks Against Multiple Link Failures","Communication networks are a cornerstone of our digital society. Since link failures in large-scale networks are inevitable, modern infrastructures rely on fast re-routing mechanisms that redirect traffic to backup paths when disruptions occur. Current solutions, however, are designed to withstand only a single link failure.Recent research by the PI and his team has demonstrated, at a conceptual level, how to enhance the resilience of communication networks against multiple simultaneous link fai",{"id":832,"funder":7,"programme":8,"title":833,"piName":10,"institution":834,"country":835,"year":13,"amount":14,"abstract":836},"cordis-european-research-council-award-101248240","Combining Cavitation and Plasma to Tackle Drinking Water Pollution","UNIVERZA V LJUBLJANI","SI","Escalating water pollution is one of the most critical global crises, jeopardizing the global supply of clean water and threatening public health on an unprecedented scale. Contaminated water, together with poor sanitation can be directly linked to transmission of various diseases such as cholera, diarrhea and hepatitis A. Our successfully completed ERC project (CoG CABUM) has shown that cavitation (almost instantaneous growth and collapse of vapor bubbles due to a local pressure drop) destroys ",{"id":838,"funder":7,"programme":8,"title":839,"piName":10,"institution":474,"country":51,"year":13,"amount":14,"abstract":840},"cordis-european-research-council-award-101286303","SAT-Design – A Web Platform for Programmable Self-Assembly","Self-assembly offers a powerful route to create nanostructures with applications in photonics, biotechnology, and advanced materials. Yet, designing building blocks that assemble into a desired target remains a fundamental challenge. Within the ERC Starting Grant SOFTWATER we contributed to the developed the SAT-assembly framework, which reformulates the design of self-assembling systems as a Boolean satisfiability (SAT) problem. This approach enabled the design of colloidal particles with water",{"id":842,"funder":7,"programme":8,"title":843,"piName":10,"institution":844,"country":107,"year":13,"amount":14,"abstract":845},"cordis-european-research-council-award-101293057","K-edge imaging for cOLOR Spectral Photon-Counting","UNIVERSITE LYON 1 CLAUDE BERNARD","Spectral photon-counting CT (SPCCT) and Color K-edge imaging represent a breakthrough in medical imaging, enabling simultaneous acquisition of morphological, functional, and molecular information in a single scan. This innovation has the potential to transform the diagnosis and management of cardiovascular, oncologic, and pulmonary diseases. However, its impact is currently limited by the absence of dedicated software for visualization, post-processing, and biomarker extraction. Clinicians and r",{"id":847,"funder":7,"programme":8,"title":848,"piName":10,"institution":849,"country":143,"year":13,"amount":14,"abstract":850},"cordis-european-research-council-award-101287828","Molecular 2D\u002FPolymer-based Memristors","UNIVERSITAT DE VALENCIA","Our previous ERC project showed that 2D materials, when combined with molecular components, can be chemically tuned to unlock entirely new physical properties. This molecular\u002F2D synergy enabled unprecedented control over electronic states and interactions, opening the door to transformative device concepts. Building on these breakthroughs, we now propose a new generation of hybrid memristors. By embedding ionic species within molecular polymers containing 2D materials such as MoS2, WS2, and MoSS",{"id":852,"funder":7,"programme":8,"title":853,"piName":10,"institution":854,"country":143,"year":13,"amount":14,"abstract":855},"cordis-european-research-council-award-101292253","Large-area, low-cost and spectrally stable dynamical thermal emitters  empowered by near-zero-index materials","UNIVERSIDAD PUBLICA DE NAVARRA","Thermal projectis a radiative process fundamental to light sources operating at mid-infrared (MIR) wavelengths. However, narrowband (partially coherent) thermal emission is conventionally achieved with the use of photonic nanostructures, which hinders their exploitation in large-area and low-cost practical applications. ERC StG NZINATECH have demonstrated that near-zero-index (NZI) materials provide an alternative route towards partially coherent thermal emission, avoiding the use of accurate na",{"id":857,"funder":7,"programme":8,"title":858,"piName":10,"institution":215,"country":20,"year":13,"amount":14,"abstract":859},"cordis-european-research-council-award-101241426","Immune signatures in sentinel lymph nodes to predict distant metastases in malignant melanoma","Malignant melanoma is a deadly disease with a 3% lifetime incidence. Currently, no clinically approved companion diagnostics exist for immunotherapy in melanoma, and sentinel lymph node (sLN) evaluation remains the cornerstone of clinical decision-making. A sensitive, robust, and clinically applicable method for identifying patients at risk of developing metastatic disease is urgently needed.Studies in murine models have shown that lymph nodes (LNs) play a dual role in tumor immunity, both suppo",{"id":861,"funder":7,"programme":8,"title":862,"piName":10,"institution":204,"country":20,"year":13,"amount":14,"abstract":863},"cordis-european-research-council-award-101248329","Engineering Gut Bacterial Phase Variation to Synergize with Immunotherapy in Melanoma Patients","Cancer immunotherapy has transformed oncology, offering new hope to patients with advanced cancers such as melanoma. However, approximately 40% of melanoma patients do not respond to current immunotherapies, highlighting the urgent need for predictive biomarkers and therapies that can increase the response and convert “non-responder” patients into “responders”. Emerging evidence indicates that the functionality of the gut microbiota plays a critical role in modulating immune responses. A common ",{"id":865,"funder":7,"programme":8,"title":866,"piName":10,"institution":588,"country":12,"year":13,"amount":14,"abstract":867},"cordis-european-research-council-award-101248528","Designing a Novel Protein Inspired Therapeutic Against Xylella","This project aims to develop an innovative protein therapy to combat Xylella fastidiosa (Xf), a plant pathogen causing significant economic losses in high-value crops such as olive, grapevine, almond, and blueberries.Xf has particularly impacted agriculture in the Mediterranean Basin, with the widespread decline of ancient olive groves in southern Italy serving as a prominent example. Current management strategies are ineffective, underscoring the need for novel disease control solutions - an is",{"id":869,"funder":7,"programme":8,"title":870,"piName":10,"institution":871,"country":101,"year":13,"amount":14,"abstract":872},"cordis-european-research-council-award-101248649","Combining Shape-change and Biofeedback to Improve Mental Health Delivery","UNIVERSITY OF BATH","Mental health conditions are set to become the leading cause of mortality and morbidity worldwide by 2030 (at a projected cost of €14.8 trillion), surpassing other major health concerns. The most effective path to lasting recovery involves Mental Health Professionals (MHPs), but despite significant efforts, they currently can only help around one in three patients recover during treatment. MHPs lack adequate tools and remain ill-equipped to support the 970 million people in need of mental health",{"id":874,"funder":7,"programme":8,"title":875,"piName":10,"institution":849,"country":143,"year":13,"amount":14,"abstract":876},"cordis-european-research-council-award-101269942","Humidity-Tolerant Adsorbents for CO2 Capture without Gas Pre-Drying","WETCAP builds on a recent breakthrough: the discovery of MUV-92, a pyrazolate-based ultramicroporous Metal-Organic Framework that efficiently captures CO2 even under very humid conditions, where existing sorbents typically fail. This Proof of Concept project aims to turn MUV-92 from a laboratory discovery into a market-ready solution for decentralized applications such as biogas upgrading, fermentation off-gases, and small-scale industrial flue gas treatment.The project will secure intellectual ",{"id":878,"funder":7,"programme":8,"title":879,"piName":10,"institution":729,"country":51,"year":13,"amount":14,"abstract":880},"cordis-european-research-council-award-101248691","An RNA aptamer-based tool  for the detection  of pathological protein aggregates in biofluids","The AptALS project aims to develop a highly sensitive and scalable RNA aptamer-based kit for detecting TDP-43 aggregates, a key biomarker in ALS. The kit consists of 3 main components: (i) biotinylated RNA aptamers that selectively bind aggregated TDP-43, (ii) a detection system (fluorescence or chemiluminescence) to quantify binding events, and (iii) a modular assay format compatible with ELISA-like workflows, allowing seamless integration into clinical laboratories. By leveraging our patented ",{"id":882,"funder":7,"programme":8,"title":883,"piName":10,"institution":575,"country":101,"year":13,"amount":14,"abstract":884},"cordis-european-research-council-award-101292592","Scalable Electronic-skins for Autonomous Intelligence  in Soft Robotics","In the emerging era of physical intelligence, soft robotics offers a transformative pathway to safe, adaptive, and intelligent human–machine interactions. Yet this vision remains constrained by a fundamental limitation: today’s soft robots largely operate “blind” due to the lack of scalable, high-resolution sensing systems that can capture both distributed tactile interactions and body deformations. This absence critically undermines their ability to perceive, adapt, and act autonomously in real",{"id":886,"funder":7,"programme":8,"title":887,"piName":10,"institution":562,"country":143,"year":13,"amount":14,"abstract":888},"cordis-european-research-council-award-101248668","Translating Epigenetic Memory into Personalized Prognostic Solutions for Chronic Lymphocytic Leukemia","Predicting the future clinical behaviour of a patient’s cancer remains a major scientific and clinical challenge. Chronic Lymphocytic Leukaemia (CLL), the most common leukaemia in the Western world, exhibits a broad range of clinical behaviours. The disease begins with a premalignant state that can later progress into an asymptomatic, progressive and highly aggressive form with a poor prognosis. Predicting the risk and timing of progression is a major unmet clinical need in CLL. Through our ERC-",{"id":890,"funder":7,"programme":8,"title":891,"piName":10,"institution":892,"country":893,"year":13,"amount":14,"abstract":894},"cordis-european-research-council-award-101248619","Low-Cost Seismic Isolation for the Developing World","ETHNICON METSOVION POLYTECHNION","EL","Even though earthquakes are a global phenomenon, their impact is tremendously disproportionate, with most deaths concentrated in the developing world. The main reason is that structural codes are not followed. However, this is not due to a “propensity for delinquency” but because earthquake-resistant methods developed in high-income countries are highly expensive. Therefore, there is an urgent need for cost-effective methods tailored to the financial resources of the developing world.Seismic iso",{"id":896,"funder":7,"programme":8,"title":897,"piName":10,"institution":169,"country":143,"year":13,"amount":14,"abstract":898},"cordis-european-research-council-award-101264238","Smart Micronozzles for Next-Generation Supercritical Fluid-Based Microthrusters","The STELLAR project aims to demonstrate the proof-of-concept for a novel micropropulsion technology —Smart Supercritical Fluid-Based Micronozzles (SSFMs)— designed to meet the growing needs of CubeSats and small satellites. These miniaturized propulsion units will use supercritical fluids to deliver compact, efficient, and tunable thrust, addressing critical limitations in current systems, such as low thrust density, poor scalability, and integration complexity. SSFMs combine advanced microfabri",{"id":900,"funder":7,"programme":8,"title":901,"piName":10,"institution":371,"country":12,"year":13,"amount":14,"abstract":902},"cordis-european-research-council-award-101248580","Reversing Tumor Immunotherapy Resistance via TME Modulation","T cell infiltration and persistence in solid tumors are crucial for the success of T cell-based immunotherapies, yet the tumor microenvironment (TME) often suppresses T cell access and function. Our ERC-funded research has identified a G protein-coupled receptor (GPCR), activated by a metabolite commonly enriched in solid tumors, that substantially impairs T cells. We showed that inhibition of this GPCR enhances T cell infiltration, persistence, and cytotoxicity, thereby substantially improving ",{"id":904,"funder":7,"programme":8,"title":905,"piName":10,"institution":528,"country":143,"year":13,"amount":14,"abstract":906},"cordis-european-research-council-award-101284650","Unlocking natural behaviour studies with standard two-photon microscopes","Two-photon (2P) microscopy is one of the most widely used tools in neuroscience to study neuronal activity with single-cell resolution. Yet, current 2P systems are largely restricted to head-fixed animals, limiting the scope of behavioural studies. To overcome this barrier, we have recently developed a novel fiber-based miniaturized approach that enables high-resolution 2P optical studies in freely moving animals. This proposal aims to transform this innovation into a robust, user-friendly platf",{"id":908,"funder":7,"programme":8,"title":909,"piName":10,"institution":337,"country":89,"year":13,"amount":14,"abstract":910},"cordis-european-research-council-award-101241357","Photonic Integrated Circuit for Single Emitter Detection","Single emitters in wide-bandgap semiconductors are key elements of future optical quantum technologies, including sensors, circuits, and fiber communication. The standard approach to detecting and characterizing single emitters is optical fluorescence microscopy, which requires a laboratory infrastructure due to the use of free-space optics. However, in order to integrate single emitters into functional devices and operate them in demanding environments, the optics must be compact, robust, and l",{"id":912,"funder":7,"programme":8,"title":913,"piName":10,"institution":914,"country":12,"year":13,"amount":14,"abstract":915},"cordis-european-research-council-award-101248720","Feel my Steps: Co-Creating Gait Rehabilitation through Sensory Augmentation","TECHNISCHE UNIVERSITAET MUENCHEN","For patients with neurological gait impairment, rehabilitation can be challenging and even frustrating due to a lack of sensory feedback. In many neurological conditions, motor and sensory pathways are equally affected and therefore require a combined therapeutic approach. In this proof-of-concept study, we will validate the functionality and usability of an innovative sensory augmentation system based on the combination of multi-sensory insoles and machine learning models for step prediction, w",{"id":917,"funder":7,"programme":8,"title":918,"piName":10,"institution":919,"country":107,"year":13,"amount":14,"abstract":920},"cordis-european-research-council-award-101247370","Peptidomimetic therapy to promote central Nervous System repair","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","Vision enables 70% of our sensorial interactions with the outside world, making blindness a devastating condition with profound impact on quality of life. Glaucoma, the second leading cause of blindness globally after cataracts, affects over 80 million people worldwide, including more than 1 million in France alone. The disease impacts approximately 2% of the population over 40 years old and 10% of those over 70. With an aging global population, these numbers are projected to rise significantly ",{"id":922,"funder":7,"programme":8,"title":923,"piName":10,"institution":919,"country":107,"year":13,"amount":14,"abstract":924},"cordis-european-research-council-award-101248700","A new generation of injectable implants based on Cell-Assembled extracellular Matrix (CAM)","Injectable implants are widely used to treat numerous medical conditions, such as stress urinary incontinence, which affects 1 in 5 women. They also represent a large fraction of aesthetic procedures (e.g., wrinkle correction). The efficacy of current products is hampered by the fact that they create a chronic inflammatory response called the Foreign Body Reaction (FBR). As a result, implants have limited durability, requiring repeated procedures, and are associated with complications such as ch",{"id":926,"funder":7,"programme":8,"title":927,"piName":10,"institution":928,"country":143,"year":13,"amount":14,"abstract":929},"cordis-european-research-council-award-101247638","Evaluation of the biotechnological interest of an H2-overproducing bacteria isolated from the deep subsurface","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","The biotechnological production of hydrogen (H2) as a clean energy source faces distinct challenges and limitations. These include the need to balance the requirements and efficiency of metabolic reactions involved in H2 generation, improve the utilization of industrial waste byproducts as substrates, and address the relatively low level of commercialization. In consequence, there is an impending need to searching for and identifying microorganisms with new metabolic pathways capable to produce ",{"id":931,"funder":7,"programme":8,"title":932,"piName":10,"institution":815,"country":101,"year":13,"amount":14,"abstract":933},"cordis-european-research-council-award-101292234","Rapid Decoupled Electrochemical Synthesis of Syngas","RapidSyn aims to deliver a breakthrough pathway for turning CO2 into valuable syngas quickly, efficiently, and with renewable power at its core. Building on the ERC Starting Grant project DeCO-HVP, we have shown that electrolytically generated redox agents can drive a revolutionary decoupled electrocatalytic process, producing both formate and tunable syngas mixtures at remarkable rates. This unique approach integrates renewable electricity seamlessly, enabling a genuinely decarbonised route for",{"id":935,"funder":7,"programme":8,"title":936,"piName":10,"institution":465,"country":51,"year":13,"amount":14,"abstract":937},"cordis-european-research-council-award-101292472","Mutagenic chemotherapy and inhibition of mismatch repair as a strategy to boost anti-tumor immune response","In colorectal cancer (CRC), the efficacy of immunotherapy is currently limited to a small subgroup of tumors characterized by mismatch repair (MMR) deficiency. Conversely, little or no clinical benefit has been shown in the large majority of CRCs with MMR proficiency, which are accordingly defined as immune-cold tumors. Determining how to turn an immune-cold into a hot (immunotherapy responsive) tumor remains a major scientific challenge and an unmet clinical need. Building on our recent demonst",{"id":939,"funder":7,"programme":8,"title":940,"piName":10,"institution":100,"country":101,"year":13,"amount":14,"abstract":941},"cordis-european-research-council-award-101248198","Resilient Temperature- and Pressure-Sensitive Paints for Hyperspectral Imaging","The RESILIENT project will engineer mechanically durable and optically efficient coatings, which may be facilely applied as a photoluminescent paint useful for in situ detection and non-contact visualization of surface temperature and pressure. This non-invasive remote sensing technology will harness our recently discovered luminescent “Guest@MOF” composite materials, realised through the nanoscale confinement of fluorophores (as guest) incarcerated in the pores of a metal-organic framework (MOF",{"id":943,"funder":7,"programme":8,"title":944,"piName":10,"institution":945,"country":231,"year":13,"amount":14,"abstract":946},"cordis-european-research-council-award-101248615","Monitoring War Destruction","LISER - LUXEMBOURG INSTITUTE OF SOCIO-ECONOMIC RESEARCH","The Monitoring War Destruction (MONWADES) project aims to develop an automated system for assessing war-related destruction using high-resolution satellite imagery and machine learning. Current methods, which rely on manual detection and eyewitness reports, are often slow, expensive, and prone to bias. By integrating computer vision and deep learning techniques, MONWADES seeks to provide a more efficient, accurate, and cost-effective solution for damage assessment, in different conflict zones ar",{"id":948,"funder":7,"programme":8,"title":949,"piName":10,"institution":950,"country":101,"year":13,"amount":14,"abstract":951},"cordis-european-research-council-award-101248008","Biocatalytic Deracemisation of Atropisomeric Drug Candidates","UNIVERSITY OF BRISTOL","Drugs that are chiral due to slow bond rotation (atropisomeric) are becoming more prevalent, and atropisomerism is increasingly recognised as an asset rather than a hindrance in medicinal chemistry programmes. However, although some asymmetric routes to atropisomers are established, very few methods are applicable to ‘drug-like’ atropisomers – namely those that are heavily functionalised, hydrophilic and often heterocyclic target molecules, meaning that enantiomerically pure atropisomeric drug c",{"id":953,"funder":7,"programme":8,"title":954,"piName":10,"institution":787,"country":89,"year":13,"amount":14,"abstract":955},"cordis-european-research-council-award-101247544","New generation single-shot LiDARs with the PicoAD monolithic detector","Light Detection and Ranging (LiDAR) is a remote sensing technology that measures object distances by analyzing the time-of-flight of photons. LiDARs emit short laser pulses, detect their reflections, and precisely measure travel time. Using a pixel matrix sensor, they can generate detailed 3D images, used for e.g. autonomous vehicles, industrial automation, robotics, and augmented reality.Despite being a rapidly growing emerging market, current LiDAR technology is still far from being fully deve",{"id":957,"funder":7,"programme":8,"title":958,"piName":10,"institution":523,"country":107,"year":13,"amount":14,"abstract":959},"cordis-european-research-council-award-101290531","Capattery ion gradient based bioelectrochemical energy storage system","CAPION will develop a novel ion-gradient-based bioelectrochemical energy storage system, leveraging biologically inspired components to overcome the limitations of conventional batteries and supercapacitors. As society moves toward increased electrification, miniaturisation and sustainability, the demand for low-voltage, compact, and environmentally neutral energy solutions is growing rapidly, particularly in healthcare, embedded electronics and autonomous sensing applications. Existing energy s",{"id":961,"funder":7,"programme":8,"title":962,"piName":10,"institution":963,"country":143,"year":13,"amount":14,"abstract":964},"cordis-european-research-council-award-101247206","Ultrafast topological spectroscopy using structured light assisted by artificial intelligence","UNIVERSIDAD DE SALAMANCA","In the era of quantum materials, material properties can be precisely tailored at the smallest (nanometer) and fastest (femtosecond to attosecond) scales ever controlled by humankind. Among them, atomically thin quantum materials stand out due to their remarkable conductivity and optical transparency, making them highly attractive for semiconductor and photonic industries. SMART-TOPOSPEC, integrating a team between University of Salamanca, SME Sphere Ultrafast Photonics and Lund University, aims",200,{"programme":8,"total":967,"withPiName":968,"firstYear":969,"lastYear":970,"countryCount":971,"perYear":972,"topInstitutions":1010,"topCountries":1078},2347,7,2014,2027,31,[973,975,978,980,982,985,988,991,994,997,1000,1003,1006,1008],{"year":969,"count":974},13,{"year":976,"count":977},2015,142,{"year":979,"count":977},2016,{"year":981,"count":965},2017,{"year":983,"count":984},2018,160,{"year":986,"count":987},2019,176,{"year":989,"count":990},2020,174,{"year":992,"count":993},2021,120,{"year":995,"count":996},2022,198,{"year":998,"count":999},2023,231,{"year":1001,"count":1002},2024,237,{"year":1004,"count":1005},2025,265,{"year":13,"count":1007},264,{"year":970,"count":1009},25,[1011,1014,1017,1020,1023,1026,1029,1032,1035,1037,1039,1042,1045,1048,1050,1053,1056,1058,1061,1063,1065,1067,1070,1073,1075],{"name":1012,"count":1013},"Centre National de la Recherche Scientifique CNRS",84,{"name":1015,"count":1016},"Weizmann Institute of Science",65,{"name":1018,"count":1019},"Technion - Israel Institute of Technology",43,{"name":1021,"count":1022},"The Chancellor Masters and Scholars of the University of Cambridge",42,{"name":1024,"count":1025},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",41,{"name":1027,"count":1028},"Fondazione Istituto Italiano di Tecnologia",34,{"name":1030,"count":1031},"Tel Aviv University",33,{"name":1033,"count":1034},"Imperial College of Science Technology and Medicine",32,{"name":1036,"count":1034},"Politecnico di Milano",{"name":1038,"count":971},"Institut National de la Sante Et de la Recherche Medicale",{"name":1040,"count":1041},"Ecole Polytechnique Federale de Lausanne",30,{"name":1043,"count":1044},"Universiteit Twente",29,{"name":1046,"count":1047},"The Hebrew University of Jerusalem",28,{"name":1049,"count":1047},"Universiteit Gent",{"name":1051,"count":1052},"The Chancellor, Masters and Scholars of the University of Oxford",27,{"name":1054,"count":1055},"Danmarks Tekniske Universitet",24,{"name":1057,"count":1055},"Vib Vzw",{"name":1059,"count":1060},"Katholieke Universiteit Leuven",23,{"name":1062,"count":1060},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",{"name":1064,"count":1060},"Technische Universitaet Muenchen",{"name":1066,"count":1060},"Technische Universiteit Delft",{"name":1068,"count":1069},"The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undivided Trinity of Queen Elizabeth Near Dublin",22,{"name":1071,"count":1072},"Technische Universiteit Eindhoven",21,{"name":1074,"count":1072},"Universiteit Leiden",{"name":1076,"count":1077},"Eidgenoessische Technische Hochschule Zuerich",20,[1079,1081,1083,1085,1087,1089,1091,1093,1095,1097,1099,1101,1103,1105,1107,1109,1110,1112,1115,1117,1119,1121,1123,1124,1127],{"name":12,"count":1080},299,{"name":143,"count":1082},273,{"name":101,"count":1084},261,{"name":45,"count":1086},254,{"name":51,"count":1088},221,{"name":107,"count":1090},215,{"name":20,"count":1092},191,{"name":33,"count":1094},109,{"name":89,"count":1096},85,{"name":27,"count":1098},72,{"name":95,"count":1100},62,{"name":149,"count":1102},50,{"name":67,"count":1104},48,{"name":39,"count":1106},47,{"name":210,"count":1108},40,{"name":893,"count":1077},{"name":175,"count":1111},19,{"name":1113,"count":1114},"NO",17,{"name":782,"count":1116},12,{"name":73,"count":1118},11,{"name":231,"count":1120},10,{"name":557,"count":1122},8,{"name":835,"count":1122},{"name":1125,"count":1126},"HU",5,{"name":1128,"count":1129},"HR",2]