[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-proof-of-concept-2027":3,"awarded-stats-erc-proof-of-concept":145},{"awarded":4,"total":144},[5,16,21,27,33,39,44,50,55,60,65,70,76,82,88,93,99,104,110,115,121,126,130,134,139],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-101334863","European Research Council","ERC Proof of Concept","Gene Regulatory Analysis for Stress in Plants",null,"UNIVERSITEIT LEIDEN","NL",2027,"€150,000","Global food security is increasingly threatened by climate change, population growth, and the rapid spread of plant diseases, which together cause substantial crop losses and economic damage worldwide. Developing crop varieties with improved disease resistance is therefore a major priority for sustainable agriculture. However, breeding for disease resistance remains challenging because the underlying regulatory mechanisms controlling plant immune responses are highly complex.\nThe GRASP (Gene Reg",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":12,"year":13,"amount":14,"abstract":20},"cordis-european-research-council-award-101334672","Functional cementitious materials for energy harvesting","TECHNISCHE UNIVERSITEIT DELFT","FUN-CRETE aims to translate recent advances in auxetic cementitious cellular composites into a first application-oriented demonstration of infrastructure-integrated energy harvesting. The underlying ERC-funded research has established a new class of cementitious materials with exceptional deformability, damage resistance and recoverable “second-elasticity” behaviour enabled by architected auxetic geometries. This project builds directly on those results by exploring whether such controlled, reco",{"id":22,"funder":7,"programme":8,"title":23,"piName":10,"institution":24,"country":25,"year":13,"amount":14,"abstract":26},"cordis-european-research-council-award-101334561","Standardized patient‑friendly computational language mapping to guide epilepsy surgery","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","FR","This Proof of Concept (PoC) translates key results from the ERC COG SPEEDY project into a bedside workflow for presurgical language mapping in drug resistant epilepsy. Electrical Stimulation Mapping (ESM) is the clinical gold standard to avoid resecting eloquent cortex, but it is time consuming, fatiguing, and often yields non-informative negative stimulations when language is not engaged. SPEEDY-Clinic combines a patient friendly, self paced bedside acquisition system for naturalistic listening",{"id":28,"funder":7,"programme":8,"title":29,"piName":10,"institution":30,"country":31,"year":13,"amount":14,"abstract":32},"cordis-european-research-council-award-101334764","Translation-Guided RNA engineering Platform for Cardiac disease","JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN","DE","Many inherited diseases arise not merely because a gene is mutated, but because cells no longer produce enough of the right protein. Because pathogenic variants are often highly diverse and spread across the gene, correcting each mutation individually is difficult to scale. TRANSLATE introduces a new therapeutic logic: precise translation engineering at the RNA level to reinstate physiological protein output without genomic modification in genetic dosage disorders. TRANSLATE builds on discoverie",{"id":34,"funder":7,"programme":8,"title":35,"piName":10,"institution":36,"country":37,"year":13,"amount":14,"abstract":38},"cordis-european-research-council-award-101335274","Conditioned CAR-T cells (cirCAR-T) for enhanced tumor immmunotherapy","UNIVERSITE DE GENEVE","CH","Chimeric antigen receptor T-cell (CAR-T) therapy is a breakthrough immunotherapy for aggressive blood cancers. With >250 companies active in the field, >1,200 CAR- T variants in clinical development, and a market exceeding $5B, CAR-T therapies represent an expanding biomedical sector. However, despite response rates of up to 90%, long-term remissions remain limited (30–40%), and efficacy in solid tumors remains poor, highlighting a major unmet medical need. Improving CAR-T cell potency, persiste",{"id":40,"funder":7,"programme":8,"title":41,"piName":10,"institution":42,"country":37,"year":13,"amount":14,"abstract":43},"cordis-european-research-council-award-101334906","Metabolic Hepatoprotection to Enable Curative Cancer Therapy in Patients with Vulnerable Livers","UNIVERSITAET BERN","SAFE-LIVER aims to establish proof-of-concept for a first-in-class metabolic hepatoprotectant that enables safe delivery of cancer therapies in patients with compromised liver function. Liver toxicity is a major barrier to curative cancer therapy. Radiotherapy and chemotherapy frequently cause hepatic injury that limits treatment intensity or excludes patients entirely. This problem is particularly severe in patients with pre-existing liver disease such as non-alcoholic fatty liver disease (NAFL",{"id":45,"funder":7,"programme":8,"title":46,"piName":10,"institution":47,"country":48,"year":13,"amount":14,"abstract":49},"cordis-european-research-council-award-101334886","Single-Atom Cartridges: From Powder to Product","POLITECNICO DI MILANO","IT","SAC3 takes the world’s first structured single-atom catalyst (demonstrated within the ERC StG “SAC_2.0” using vat photopolymerization) and does what laboratory discoveries rarely achieve: turns it into a manufacturable technology. The goal is not to discover a better catalyst but to validate a manufacturing process for obtaining atomically precise catalytic cartridges ready for integration into industrial continuous-flow reactors.\nConventional heterogeneous catalysts expose only 5-20% of their m",{"id":51,"funder":7,"programme":8,"title":52,"piName":10,"institution":53,"country":31,"year":13,"amount":14,"abstract":54},"cordis-european-research-council-award-101335373","Short Tandem Repeat Instability QuantIfier for Next-Generation sequencing","DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV","Over 50 severe genetic disorders are caused by short tandem repeat (STR) expansions. Emerging evidence indicates that increased STR instability plays a critical role in their pathogenesis. However, current analysis tools can only determine basic STR length but not instability, severely limiting both therapeutic development and clinical care. Our project aims to commercialize innovative software that enables targeted and genome-wide quantification of STR instability, addressing urgent needs in dr",{"id":56,"funder":7,"programme":8,"title":57,"piName":10,"institution":58,"country":31,"year":13,"amount":14,"abstract":59},"cordis-european-research-council-award-101335596","LIVEMAP: Live-cell mapping of drug–protein interactions  across the human proteome","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","Drug discovery remains one of the most challenging endeavours in modern medicine. Despite decades of investment, approximately 90% of clinical drug candidates fail before reaching patients, with late-stage failures costing billions and delaying effective therapies. A key underlying reason is the inability to reliably determine the full range of proteins a drug engages in living cells, including both intended targets and unintended off-targets. Existing technologies either miss large portions of ",{"id":61,"funder":7,"programme":8,"title":62,"piName":10,"institution":63,"country":12,"year":13,"amount":14,"abstract":64},"cordis-european-research-council-award-101335456","Robust and Scalable Catalytic Ball Milling for Plastic Recycling (Scalable IMPACT)","UNIVERSITEIT UTRECHT","Polyolefins such as polyethylene and polypropylene make up more than 50% of global polymer production and are thus a major contributor to waste accumulation in the environment. Classical recycling via melting and reshaping usually leads to a lower quality product. Chemical recycling is proposed as solution, in which the chemical bonds of the polymer are broken to obtain chemical building blocks. It is most desired to produce monomers to make high quality polymers again. However, for polyolefins ",{"id":66,"funder":7,"programme":8,"title":67,"piName":10,"institution":68,"country":48,"year":13,"amount":14,"abstract":69},"cordis-european-research-council-award-101335612","Sustainable and Ultra-PeRforming supercApacitors with 3D Laser-Induced Graphene  (SUPRALIG)","POLITECNICO DI TORINO","Electrochemical energy storage devices such as supercapacitors and batteries rely on metallic current collectors that are costly, dense and environmentally intensive to manufacture. These limitations hinder the development of flexible, lightweight, and scalable energy storage technologies needed for emerging applications including wearable electronics, IoT devices, and distributed renewable energy systems. SUPRALIG proposes a disruptive alternative: the use of Laser-Induced Graphene (LIG) as a t",{"id":71,"funder":7,"programme":8,"title":72,"piName":10,"institution":73,"country":74,"year":13,"amount":14,"abstract":75},"cordis-european-research-council-award-101335322","DeepSonic: Deep sea soundscapes from machine learning","UNIVERSITY COLLEGE LONDON","UK","Acoustic recordings of ocean noise offer vital insights into marine ecosystems, revealing the impacts of human activities such as noise pollution and climate change. Large baleen whales like blue and fin whales emit low-frequency calls that travel long distances and can be detected by ocean bottom seismometers (OBS)—instruments originally deployed for seismological research. This makes OBSs a cost-effective, passive tool for long-term marine mammal and ocean noise monitoring in deep and remote a",{"id":77,"funder":7,"programme":8,"title":78,"piName":10,"institution":79,"country":80,"year":13,"amount":14,"abstract":81},"cordis-european-research-council-award-101334665","Scalable MXene-Based Thermal Shields for Next-Generation Radar and Aerospace Electronics","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","ES","THERMOBARRIER aims to develop an inorganic tunable thermal barrier based on metal transitional carbides, i.e. MXenes, designed to stabilize electronics that are sensitive to temperature variations. By material engineering of MXenes, we create films with record-low thermal conductivity, flexibility, stability in thermal cycles, and electromagnetic compatibility with the targeted electronics.\n\nPreliminary work within ERC THERMO2DEAL shows feasibility and scalability, protecting the IP of the therm",{"id":83,"funder":7,"programme":8,"title":84,"piName":10,"institution":85,"country":86,"year":13,"amount":14,"abstract":87},"cordis-european-research-council-award-101334839","Targeting liquid organelles to develop new antiviral strategies against influenza A virus infections","UNIVERSIDADE CATOLICA PORTUGUESA","PT","Rising antiviral resistance, vaccine hesitancy, and more frequent zoonotic spillovers, amplified by climate change and ecosystem disruption, demand for more and different antiviral solutions. Most licensed influenza antivirals act by inhibiting viral protein functions and can be undermined by resistance. LOFlu_TREAT develops an evolution-resilient approach against epidemic and pandemic influenza A virus (IAV) by modulating the material properties of virus-induced biomolecular condensates, membra",{"id":89,"funder":7,"programme":8,"title":90,"piName":10,"institution":91,"country":48,"year":13,"amount":14,"abstract":92},"cordis-european-research-council-award-101334827","Lipopolysaccharide Lipid A Profiling to Guide Microbiome-Supported Immunotherapy in Melanoma","UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II","Understanding how gut microbiota shapes host physiology is central to biomedicine. Yet current microbiome studies largely infer function from genetic signatures rather than directly measuring biochemical outputs. This limitation becomes critical in interventional settings such as faecal microbiota transplantation (FMT) in oncology, where donor-to-recipient transfer can alter immune tone in ways not captured by taxonomy alone.\nAmong key microbial immune modulators are lipopolysaccharides (LPS) fr",{"id":94,"funder":7,"programme":8,"title":95,"piName":10,"institution":96,"country":97,"year":13,"amount":14,"abstract":98},"cordis-european-research-council-award-101334946","Engineering microglia to treat Alzheimer’s disease","VIB VZW","BE","\"Microglia, the resident immune cells of the brain, are increasingly implicated in Alzheimer’s disease (AD) pathogenesis by genetic studies and functional evidence showing defective recognition and clearance of amyloid-beta (Aβ) peptides. Inefficient microglial clearance of Aβ plaques leads to progressive accumulation, enhanced neuroinflammation, and neuronal loss. While current antibody therapies target Aβ, these interventions face significant safety concerns, limiting pharmacology. This ERC Pr",{"id":100,"funder":7,"programme":8,"title":101,"piName":10,"institution":102,"country":31,"year":13,"amount":14,"abstract":103},"cordis-european-research-council-award-101335269","Biocompatible agents for preventive diagnostics in vascular disease","TECHNISCHE UNIVERSITAET MUENCHEN","Perfusable vascularized microphysiological systems such as vasculature- and thrombosis-on-chip platforms are emerging as powerful tools to study cardiovascular disease and evaluate therapies. Monitoring biochemical processes such as platelet activation, thrombin generation, or endothelial signaling within these systems remains challenging. Current readout strategies rely mainly on continuous microscopy or integrated sensors, which are difficult to scale across extended vascular networks and inte",{"id":105,"funder":7,"programme":8,"title":106,"piName":10,"institution":107,"country":108,"year":13,"amount":14,"abstract":109},"cordis-european-research-council-award-101334978","Utilising the principles of excluded volume effect to heal cutaneous pathologies using in vitro engineered cell-assembled living substitutes","PANEPISTIMIO IOANNINON","EL","The ERC-2019-Co-ACHIEVE programme investigates the fundamentals of excluded volume effect, through the application of macromolecular crowding (MMC), in cell culture. Outcomes of the ERC-2019-Co-ACHIEVE programme demonstrate the potential of MMC in regenerative medicine, drug discovery and cellular agriculture. The ERC-2026-PoC-EVE_HEALS programme will utilise MMC to develop tissue engineered medicines for wound healing applications.",{"id":111,"funder":7,"programme":8,"title":112,"piName":10,"institution":113,"country":25,"year":13,"amount":14,"abstract":114},"cordis-european-research-council-award-101334480","Live-testing a light-speed gravity-based tsunami warning system","INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT","Earthquakes caused nearly one million fatalities in the last 25 years and billions of euros of economic loss. Earthquake early warning systems exist in some countries at risk. They send alerts based on the rapid analysis of early seismic waves generated by the earthquake and therefore only provide a few seconds of warning before the strongest shakings. Moreover, for fundamental reasons, these systems systematically underestimate the magnitude of large events, which results in dramatic underestim",{"id":116,"funder":7,"programme":8,"title":117,"piName":10,"institution":118,"country":119,"year":13,"amount":14,"abstract":120},"cordis-european-research-council-award-101334294","Automated Security Validation for Zero-Knowledge Systems","TECHNISCHE UNIVERSITAET WIEN","AT","Zero-knowledge (ZK) systems are foundational to modern\nprivacy-preserving technologies, yet ensuring the correctness of\ntheir increasingly complex implementations remains a major\nbottleneck. The high stakes involved---for instance, the 745\nmillion USD in digital assets managed by the Linea blockchain\nthat relies on such infrastructure---highlight the critical need\nfor a scalable and reliable solution. Currently, correctness\nrelies heavily on costly and labor-intensive manual audits, which\ndo not",{"id":122,"funder":7,"programme":8,"title":123,"piName":10,"institution":124,"country":48,"year":13,"amount":14,"abstract":125},"cordis-european-research-council-award-101334860","Multi-model Approach for Runup and INundation Analysis","UNIVERSITA CA' FOSCARI  VENEZIA","The MARINA project addresses the critical need for accurate, real-time coastal flood forecasting. Current operational tools rely either on computationally expensive process-based models or fast but inaccurate empirical formulations. MARINA bridges this gap by developing a scalable Decision Support System based on a probabilistic multi-model framework. Originating from the ERC Starting Grant WARMCOASTS, this technology utilizes a hybrid architecture where offline high-fidelity simulations are use",{"id":127,"funder":7,"programme":8,"title":128,"piName":10,"institution":58,"country":31,"year":13,"amount":14,"abstract":129},"cordis-european-research-council-award-101335277","Safeguard Repressor-Mediated Cell Fate Lock Gene Therapy for Glioblastoma","\"Glioblastoma (GBM) remains the most lethal primary brain tumour, with a median survival of 15 months despite maximal treatment,  unchanged in two decades. Over 95% of clinical trials have failed. The fundamental reason is cell fate plasticity: GBM cells switch between phenotypic states to evade any single therapy. No current approach addresses the regulatory machinery that permits this switching.\n\nSafeCure will translate two discoveries from ERC Starting Grant SafeFate into a first-in-class gen",{"id":131,"funder":7,"programme":8,"title":132,"piName":10,"institution":96,"country":97,"year":13,"amount":14,"abstract":133},"cordis-european-research-council-award-101335602","AD-LINK: Reversing Early Aβ-Driven Network Hyperexcitability","Despite decades of research, there is currently no drug capable of preventing Alzheimer’s disease (AD), and ~99% of the drug candidates ultimately fail in clinical trials. This high failure rate is largely due to the lack of reliable preclinical models that enable continuous, longitudinal testing of therapeutic interventions from the earliest, pre-symptomatic stages of the disease.\n\nAD‑LINK is a chronic neurotechnology platform designed to extract high‑resolution neurophysiological signatures of",{"id":135,"funder":7,"programme":8,"title":136,"piName":10,"institution":137,"country":108,"year":13,"amount":14,"abstract":138},"cordis-european-research-council-award-101287771","Next-Gen Immunomodulatory Nanoplatforms Targeting Regulatory T Cell Metabolism to combat cancer","IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON","Regulatory T cells (Tregs) are vital for maintaining homeostasis and self-tolerance. This immunosuppressive nature is exploited by cancer for tumour growth. Consequently, Treg accumulation in tumors is associated with poor prognosis and is a fundamental impediment to the success of immunotherapy. Thus, Treg suppressive mechanisms emerge as appealing therapeutic targets. However, current approaches focus on their systemic elimination, failing to yield significant clinical outcomes and are accompa",{"id":140,"funder":7,"programme":8,"title":141,"piName":10,"institution":142,"country":119,"year":13,"amount":14,"abstract":143},"cordis-european-research-council-award-101286252","Self-powered wireless sensor node through ultrahigh performance energy storage capacitors","SILICON AUSTRIA LABS GMBH","Wireless sensor nodes (WSN) are enablers for the Internet of Things (IoT), as they allow to collect distributed data about the environment, machine conditions, etc., even at remote locations. The key aspect for WSN is their energy-autonomy, namely perpetual operation without any external energy source. This is generally achieved by combining an energy harvesting module (e.g. solar cell) with a suitable energy storage module. Common energy storage devices for WSNs are batteries and supercapacitor",25,{"programme":8,"total":146,"withPiName":147,"firstYear":148,"lastYear":13,"countryCount":149,"perYear":150,"topInstitutions":189,"topCountries":257},2347,7,2014,31,[151,153,156,158,161,164,167,170,173,176,179,182,185,188],{"year":148,"count":152},13,{"year":154,"count":155},2015,142,{"year":157,"count":155},2016,{"year":159,"count":160},2017,200,{"year":162,"count":163},2018,160,{"year":165,"count":166},2019,176,{"year":168,"count":169},2020,174,{"year":171,"count":172},2021,120,{"year":174,"count":175},2022,198,{"year":177,"count":178},2023,231,{"year":180,"count":181},2024,237,{"year":183,"count":184},2025,265,{"year":186,"count":187},2026,264,{"year":13,"count":144},[190,193,196,199,202,205,208,211,214,216,218,221,224,227,229,232,235,237,240,242,244,246,249,252,254],{"name":191,"count":192},"Centre National de la Recherche Scientifique CNRS",84,{"name":194,"count":195},"Weizmann Institute of Science",65,{"name":197,"count":198},"Technion - Israel Institute of Technology",43,{"name":200,"count":201},"The Chancellor Masters and Scholars of the University of Cambridge",42,{"name":203,"count":204},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",41,{"name":206,"count":207},"Fondazione Istituto Italiano di Tecnologia",34,{"name":209,"count":210},"Tel Aviv University",33,{"name":212,"count":213},"Imperial College of Science Technology and Medicine",32,{"name":215,"count":213},"Politecnico di Milano",{"name":217,"count":149},"Institut National de la Sante Et de la Recherche Medicale",{"name":219,"count":220},"Ecole Polytechnique Federale de Lausanne",30,{"name":222,"count":223},"Universiteit Twente",29,{"name":225,"count":226},"The Hebrew University of Jerusalem",28,{"name":228,"count":226},"Universiteit Gent",{"name":230,"count":231},"The Chancellor, Masters and Scholars of the University of Oxford",27,{"name":233,"count":234},"Danmarks Tekniske Universitet",24,{"name":236,"count":234},"Vib Vzw",{"name":238,"count":239},"Katholieke Universiteit Leuven",23,{"name":241,"count":239},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",{"name":243,"count":239},"Technische Universitaet Muenchen",{"name":245,"count":239},"Technische Universiteit Delft",{"name":247,"count":248},"The Provost, Fellows, Foundation Scholars & the Other Members of Board, of the College of the Holy & Undivided Trinity of Queen Elizabeth Near Dublin",22,{"name":250,"count":251},"Technische Universiteit Eindhoven",21,{"name":253,"count":251},"Universiteit Leiden",{"name":255,"count":256},"Eidgenoessische Technische Hochschule Zuerich",20,[258,260,262,264,266,268,270,273,275,277,280,282,285,288,291,293,294,297,300,303,306,309,312,314,317],{"name":31,"count":259},299,{"name":80,"count":261},273,{"name":74,"count":263},261,{"name":12,"count":265},254,{"name":48,"count":267},221,{"name":25,"count":269},215,{"name":271,"count":272},"IL",191,{"name":97,"count":274},109,{"name":37,"count":276},85,{"name":278,"count":279},"SE",72,{"name":119,"count":281},62,{"name":283,"count":284},"DK",50,{"name":286,"count":287},"IE",48,{"name":289,"count":290},"FI",47,{"name":86,"count":292},40,{"name":108,"count":256},{"name":295,"count":296},"TR",19,{"name":298,"count":299},"NO",17,{"name":301,"count":302},"CY",12,{"name":304,"count":305},"CZ",11,{"name":307,"count":308},"LU",10,{"name":310,"count":311},"PL",8,{"name":313,"count":311},"SI",{"name":315,"count":316},"HU",5,{"name":318,"count":319},"HR",2]