[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-starting-grant-2009":3,"awarded-stats-erc-starting-grant":886},{"awarded":4,"total":885},[5,16,22,29,35,40,46,53,60,65,70,76,83,90,95,102,108,112,119,123,128,133,139,144,149,154,161,166,172,177,182,188,193,199,205,211,217,222,227,233,238,244,250,257,264,270,275,282,288,293,299,305,309,315,320,326,331,337,343,349,355,360,365,369,375,381,385,391,398,402,408,414,418,424,429,435,440,445,450,454,459,463,468,474,478,484,490,497,502,508,513,518,523,529,534,540,544,549,555,560,565,571,578,584,590,596,601,606,610,615,620,626,632,637,643,649,655,661,667,673,678,684,690,695,700,704,710,715,721,728,734,739,745,751,756,762,768,772,778,782,788,793,799,805,811,817,823,830,836,840,846,852,859,864,870,875,880],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-european-research-council-award-goodshape-fp7-erc-stg-205693","European Research Council","ERC Starting Grant","On centroidal voronoi tessellation—energy smoothness and fast computation","Yang Liu","Institut national de recherche en informatique et en automatique","FR",2009,null,"Centroidal Voronoi tessellation (CVT) is a particular type of Voronoi tessellation that has many applications in computational sciences and engineering, including computer graphics. The prevailing method for computing CVT is Lloyd's method, which has linear convergence and is inefficient in practice. We develop new efficient methods for CVT computation and demonstrate the fast convergence of these methods. Specifically, we show that the CVT energy function has 2nd order smoothness for convex dom",{"id":17,"funder":7,"programme":8,"title":18,"piName":14,"institution":19,"country":20,"year":13,"amount":21,"abstract":18},"cordis-european-research-council-award-239858","Reconstruction of methane flux from lakes: development and application of a new approach","UNIVERSITAET BERN","CH","€1,554,000",{"id":23,"funder":7,"programme":8,"title":24,"piName":14,"institution":25,"country":26,"year":13,"amount":27,"abstract":28},"cordis-european-research-council-award-240385","Hyperbolic Systems of Conservation Laws: singular limits, properties of solutions and control problems","SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE","IT","€422,000","The research program concerns various theoretic aspects of hyperbolic conservation laws. In first place we plan to study the existence and uniqueness of solutions to systems of equations of mathematical physics with physic viscosity. This is one of the main open problems within the theory of conservation laws in one space dimension, which cannot be tackled relying on the techniques developed in the case where the viscosity matrix is the identity. Furthermore, this represents a first step toward ",{"id":30,"funder":7,"programme":8,"title":31,"piName":14,"institution":32,"country":20,"year":13,"amount":33,"abstract":34},"cordis-european-research-council-award-240328","Hybrid Cavity Quantum Electrodynamics with Atoms and Circuits","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","€1,954,464","We plan to investigate the strong coherent interaction of light and matter on the level of individual photons and atoms or atom-like systems. In particular, we will explore large dipole moment superconducting artificial atoms and natural Rydberg atoms interacting with radiation fields contained in quasi-one-dimensional on-chip microwave frequency resonators. In these resonators photons generate field strengths that exceed those in conventional mirror based resonators by orders of magnitude and t",{"id":36,"funder":7,"programme":8,"title":37,"piName":14,"institution":32,"country":20,"year":13,"amount":38,"abstract":39},"cordis-european-research-council-award-242714","Biogenesis and Functions of Telomeric Repeat-containing RNA","€1,602,600","Telomeres are heterochromatic nucleoprotein complexes located at the end of linear eukaryotic chromosomes. Contrarily to a longstanding dogma, we have recently demonstrated that mammalian telomeres are transcribed into TElomeric Repeat containing RNA (TERRA) molecules. TERRA transcripts contain telomeric RNA repeats and are produced at least in part by DNA-dependent RNA polymerase II-mediated transcription of telomeric DNA. TERRA molecules form discrete nuclear foci that co-localize with telomer",{"id":41,"funder":7,"programme":8,"title":42,"piName":14,"institution":43,"country":44,"year":13,"amount":14,"abstract":45},"cordis-european-research-council-award-240299","Singlet exciton fission as a route to more efficient dye-sensitized solar cells","TECHNISCHE UNIVERSITEIT DELFT","NL","One of the greatest scientific challenges of the coming decades will be to produce sufficient energy to meet consumption demands, particularly as fossil fuel reserves decline. A leading alternative method of producing energy is the conversion of solar energy to electricity. At present, energy produced by photovoltaic cells is significantly more expensive than that obtained by burning fossil fuels. Therefore, we need to find a method of producing solar cells more cheaply. The prime example of suc",{"id":47,"funder":7,"programme":8,"title":48,"piName":14,"institution":49,"country":50,"year":13,"amount":51,"abstract":52},"cordis-european-research-council-award-239990","Limit theorems for processes in random media","TECHNISCHE UNIVERSITAET MUENCHEN","DE","€504,000","Classical random walks (CRW) have been studied for centuries, and very detailed information is known about them. However, most of the techniques for studying CRW are based on the complete regularity and the group structure of the medium. When modeling real world phenomena, this regularity assumption rarely holds, and therefore CRW is not a sufficient model. As a result, a number of non-classical models of random walk have been suggested. These models are believed to better model actual natural p",{"id":54,"funder":7,"programme":8,"title":55,"piName":14,"institution":56,"country":57,"year":13,"amount":58,"abstract":59},"cordis-european-research-council-award-239985","Strong Probabilistically Checkable Proofs","WEIZMANN INSTITUTE OF SCIENCE","IL","€1,639,584","Probabilistically Checkable Proofs (PCPs) encapsulate the striking idea that verification of proofs becomes nearly trivial if one is willing to use randomness. The PCP theorem, proven in the early 90's, is a cornerstone of modern computational complexity theory. It completely revises our notion of a proof, leading to an amazingly robust behavior: A PCP proof is guaranteed to have an abundance of errors if attempting to prove a falsity. This stands in sharp contrast to our classical notion of a p",{"id":61,"funder":7,"programme":8,"title":62,"piName":14,"institution":56,"country":57,"year":13,"amount":63,"abstract":64},"cordis-european-research-council-award-239885","Ergodic theory on non compact spaces","€539,479","The proposal is to look for, and investigate, new ergodic theoretic types of behavior for dynamical systems which act on non compact spaces. These could include transience and non-trivial ways of escape to infinity, critical phenomena similar to phase transitions, and new types of measure rigidity. There are potential applications to smooth ergodic theory (non-uniform hyperbolicity), algebraic ergodic theory (actions on homogeneous spaces), and probability theory (weakly dependent stochastic pro",{"id":66,"funder":7,"programme":8,"title":67,"piName":14,"institution":56,"country":57,"year":13,"amount":68,"abstract":69},"cordis-european-research-council-award-239679","The Dynamic Composition of Protein Complexes: A New Perspective in Structural Biology","€1,500,000","80% of the proteome exists in complexes or large macromolecular assemblies. It is accepted that revealing the structure of these protein complexes is a key towards mechanistic understanding of cellular processes. Yet, this might not be sufficient; a higher level of complexity probably exists and protein complexes may not be static and uniform in form and function as thought. A protein complex may actually represent an ensemble of compositionally distinct entities with functional versatility. My ",{"id":71,"funder":7,"programme":8,"title":72,"piName":14,"institution":73,"country":50,"year":13,"amount":74,"abstract":75},"cordis-european-research-council-award-240460","Powerful and Efficient EUV Coherent Light Sources","FRIEDRICH-SCHILLER-UNIVERSITÄT JENA","€1,450,000","The interest in and hence the need for coherent short-wavelength (EUV spectral range) laser sources is rapidly increasing. Potentially, such sources will allow for novel approaches in fundamental science, metrology, imaging, spectroscopy and might even enable new lithographic production techniques. One example is Atto-Science, one of the groundbreaking topics in physical science of the next decade. High harmonic generation (HHG) in noble gases is considered as the most suitable technique to gene",{"id":77,"funder":7,"programme":8,"title":78,"piName":14,"institution":79,"country":80,"year":13,"amount":81,"abstract":82},"cordis-european-research-council-award-210934","Nineteenth-Century Euclid: Geometry and the Literary Imagination from Wordsworth to Wells","UNIVERSITY OF GLASGOW","UK","€323,118","This radically interdisciplinary project aims to bring a substantially new field of research – literature and mathematics studies – to prominence as a tool for investigating the culture of nineteenth-century Britain. It will result in three kinds of outcome: a monograph, two interdisciplinary and international colloquia, and a collection of essays. The project focuses on Euclidean geometry as a key element of nineteenth-century literary and scientific culture, showing that it was part of the sha",{"id":84,"funder":7,"programme":8,"title":85,"piName":14,"institution":86,"country":87,"year":13,"amount":88,"abstract":89},"cordis-european-research-council-award-239844","Quantum Optomechanics: quantum foundations and quantum information on the micro- and nanoscale","UNIVERSITAT WIEN","AT","€1,670,904","Quantum states of mechanical resonators promise access to completely new experimental regimes of physics: from unprecedented levels of force sensitivity to the generation of macroscopic quantum superpositions of massive objects containing up to 10^20 atoms. This opens up not only exciting possibilities for novel applications but also allows to (re)address fundamental questions of quantum physics, in particular its relation to the classical world. For this reason the preparation and control of me",{"id":91,"funder":7,"programme":8,"title":92,"piName":14,"institution":86,"country":87,"year":13,"amount":93,"abstract":94},"cordis-european-research-council-award-239937","Quantum entanglement and the renormalization group","€1,274,254","Among the most defining events in physics during the last decade were the spectacular advances in the field of strongly correlated quantum many body systems: the observation of quantum phase transitions in optical lattices and the realization that many body entanglement can be exploited to build quantum computers are only two of the notable breakthroughs. The description of strongly correlated quantum systems and the associated entanglement structure is still largely unexplored territory. This f",{"id":96,"funder":7,"programme":8,"title":97,"piName":14,"institution":98,"country":99,"year":13,"amount":100,"abstract":101},"cordis-european-research-council-award-240467","Serial Optical Communications for Advanced Terabit Ethernet Systems","DANMARKS TEKNISKE UNIVERSITET","DK","€1,518,387","The last two decades has seen an explosion in telecommunication bandwidth, a trend which has never ceased. Another current trend is the growing concern for the environmental footprint humankind is leaving due to various industries. The Internet traffic grows roughly by 60% per year, and internet servers today consume about 2% of the total global electric power consumption corresponding to a CO2 emission approaching 1% of the total emission caused by human beings. These trends have made it very c",{"id":103,"funder":7,"programme":8,"title":104,"piName":14,"institution":105,"country":12,"year":13,"amount":106,"abstract":107},"cordis-european-research-council-award-240039","Understanding the Physics of Galaxy Formation and Evolution at High Redshift","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","€939,600","Understanding the processes regulating galaxy formation is a major open issue in observational cosmology. We now have a fairly detailed census of the diverse high-z galaxy populations, hence time is ripe for fundamental advances in understanding galaxy formation and evolution in the crucial first few billion years. This requires to observationally constrain and clarify the physical processes that operated at those early epochs. Thanks to a new galaxy selection technique that I recently introduce",{"id":109,"funder":7,"programme":8,"title":110,"piName":14,"institution":105,"country":12,"year":13,"amount":14,"abstract":111},"cordis-european-research-council-award-240382","DESIGN AND ELABORATION OFMULTI-PHYSICS INTEGRATED NANOSYSTEMS","The innovation of DELPHINS application will consist in building a generic multi-sensor design platform for embedded multi-gas-analysis-on-chip, based on a global modelling from the individual NEMS sensors to a global multiphysics NEMS-CMOS VLSI (Very large Scale Integration) system. The latter constitute a new research field with many potential applications such as in medicine (specific diseases recognition) but also in security (toxic and complex air pollutions), in industry (perfumes, agribusi",{"id":113,"funder":7,"programme":8,"title":114,"piName":14,"institution":115,"country":116,"year":13,"amount":117,"abstract":118},"cordis-european-research-council-award-240186","Mining Graphs and Networks: a Theory-based approach","KATHOLIEKE UNIVERSITEIT LEUVEN","BE","€1,716,066","In this project we aim at formulating enhancing theoretical foundations for the emerging field of graph mining. Graph mining is the field concerned with extracting interesting patterns and knowledge from graph or network structured data, such as can be found in chemistry, bioinformatics, the world wide web, social networks etc. Recent work has shown that many standard data mining techniques can be extended to structured data and can yield interesting results, but also that when applied to comple",{"id":120,"funder":7,"programme":8,"title":121,"piName":14,"institution":115,"country":116,"year":13,"amount":14,"abstract":122},"cordis-european-research-council-award-240854","'Dead End': An Economic and Cultural History of Japan in the Age of the Great Depression, 1927-1937","The project presents an economic history and socio-cultural reconstruction of Japan in the age of the great depression; it is an attempt to demonstrate the depression's 'total' or multicontextual implications by outlining different but complimentary views of what was defined as the depression's core problems (and their possible solutions) within different social classes and within different strands of thought. Seen in historical perspective, it covers the period from the 'ShMwa financial crisis'",{"id":124,"funder":7,"programme":8,"title":125,"piName":14,"institution":115,"country":116,"year":13,"amount":126,"abstract":127},"cordis-european-research-council-award-240750","Archaeometry and Archaeology of Ancient Glass Production as a Source for Ancient Technology and Trade of Raw Materials","€954,960","In this project, innovative techniques to reconstruct ancient economies are developed and new insights in the trade and processing of mineral raw materials are gained based on interdisciplinary archaeological and archaeometrical research. An innovative methodology for and a practical provenance database of the primary origin of natron glass from the Hellenistic-Roman world will be established. The project investigates both production and consumer sites of glass raw materials using both typo-chro",{"id":129,"funder":7,"programme":8,"title":130,"piName":14,"institution":115,"country":116,"year":13,"amount":131,"abstract":132},"cordis-european-research-council-award-240002","African river basins: catchment-scale carbon fluxes and transformations","€1,745,262","This proposal wishes to fundamentally improve our understanding of the role of tropical freshwater ecosystems in carbon (C) cycling on the catchment scale. It uses an unprecedented combination of state-of-the-art proxies such as stable isotope, 14C and biomarker signatures to characterize organic matter, radiogenic isotope signatures to determine particle residence times, as well as field measurements of relevant biogeochemical processes. We focus on tropical systems since there is a striking la",{"id":134,"funder":7,"programme":8,"title":135,"piName":14,"institution":136,"country":12,"year":13,"amount":137,"abstract":138},"cordis-european-research-council-award-239920","Arrays of entangled atoms","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€1,449,600","The goal of this project is to prepare in a deterministic way, and then to characterize, various entangled states of up to 25 individual atoms held in an array of optical tweezers. Such a system provides a new arena to explore quantum entangled states of a large number of particles. Entanglement is the existence of quantum correlations between different parts of a system, and it is recognized as an essential property that distinguishes the quantum and the classical worlds. It is also a resource ",{"id":140,"funder":7,"programme":8,"title":141,"piName":14,"institution":136,"country":12,"year":13,"amount":142,"abstract":143},"cordis-european-research-council-award-206875","Regulation and function of non-coding RNAs in epigenetic processes: the paradigm of X-chromosome inactivation","€1,220,000","Some 150 years after the emergence of genetics, epigenetic mechanisms are increasingly understood to be fundamental players in phenotype transmission and development. In addition, epigenetic alterations are now linked to several human diseases including cancers. A common feature of many epigenetic phenomena, for which X-chromosome inactivation (XCI) is the paradigm, is the implication of non-coding RNAs (ncRNAs). Regulatory ncRNAs belong to 2 major classes: (i) long ncRNAs, which can be transcri",{"id":145,"funder":7,"programme":8,"title":146,"piName":14,"institution":136,"country":12,"year":13,"amount":147,"abstract":148},"cordis-european-research-council-award-240579","Turbulent Transport in the Atmosphere: Fluctuations and Extreme Events","€1,200,000","A major part of the physical and chemical processes occurring in the atmosphere involves the turbulent transport of tiny particles. Current studies and models use a formulation in terms of mean fields, where the strong variations in the dynamical and statistical properties of the particles are neglected and where the underlying fluctuations of the fluid flow velocity are oversimplified. Devising an accurate understanding of the influence of air turbulence and of the extreme fluctuations that it ",{"id":150,"funder":7,"programme":8,"title":151,"piName":14,"institution":136,"country":12,"year":13,"amount":152,"abstract":153},"cordis-european-research-council-award-243136","Epigenetic and genome stability: non coding RNA-mediated chromatin modifications in S. cerevisiae","€1,735,524","Our project is to understand the role of non coding (nc)RNA in the regulation of epigenetic landscape and gene expression. RNA interference pathway is absent in the budding yeast but recent works from our laboratory showed the existence of an original ncRNA-dependent pathway that controls gene expression in S. cerevisiae. We characterized a cryptic unstable ncRNA mediating the transcriptional silencing of the transposon Ty1 through histone methylation. Furthermore, unpublished data suggest the e",{"id":155,"funder":7,"programme":8,"title":156,"piName":14,"institution":157,"country":158,"year":13,"amount":159,"abstract":160},"cordis-european-research-council-award-239784","Intelligent Stochastic Computation Methods for Complex Statistical Model Learning","HELSINGIN YLIOPISTO","FI","€550,000","Very recently, it has been claimed that the Bayesian paradigm has revolutionized statistical thinking in numerous fields of research, as a considerable amount of novel Bayesian statistical models and estimation algorithms have gained popularity among scientists. Despite of the evident success of the Bayesian approach, there are also many research problems where the computational challenges have so far proven to be too exhaustive to promote wide-spread use of the state-of-the-art Bayesian methodo",{"id":162,"funder":7,"programme":8,"title":163,"piName":14,"institution":157,"country":158,"year":13,"amount":164,"abstract":165},"cordis-european-research-council-award-242820","Insulin resistance and diabetic nephropathy - development of novel in vivo models for drug discovery","€2,000,000","Up to one third of diabetic patients develop nephropathy, a serious complication of diabetes. Microalbuminuria is the earliest sign of the complication, which may ultimately develop to end-stage renal disease requiring dialysis or a kidney transplant. Insulin resistance and metabolic syndrome are associated with an increased risk for diabetic nephropathy. Interestingly, glomerular epithelial cells or podocytes have recently been shown to be insulin responsive. Further, nephrin, a key structural ",{"id":167,"funder":7,"programme":8,"title":168,"piName":14,"institution":169,"country":12,"year":13,"amount":170,"abstract":171},"cordis-european-research-council-award-207583","The paradoxical role of type I interferons in Hepatitis C disease pathogenesis and treatment","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","€1,098,000","Hepatitis C virus (HCV) presents a significant public health problem with nearly 200 million infected people worldwide. Over the past three years, we have developed partnerships with clinicians and epidemiologists so that we can achieve better insight into immune pathogenesis of both acute and chronic HCV infection. My newly created research unit is committed to defining the complex interplay between virus and host from the perspective of type I interferons (IFNs) and IFN induced gene products. ",{"id":173,"funder":7,"programme":8,"title":174,"piName":14,"institution":169,"country":12,"year":13,"amount":175,"abstract":176},"cordis-european-research-council-award-243106","Sensory perception: neural representation and modulation","€1,851,600","Perception has intrigued philosophers and scientists since Aristotle ~2,300 years ago, but only recently it became technically possible to address its underlying neural mechanisms. The main scientific research approach still focuses on studying the evoked responses to a perceived sensory stimulus. However, in a state of sensory deprivation, sensory areas in the brain remain highly active. This activity, once interpreted as irrelevant noise, has been found to exhibit highly coherent spatiotempora",{"id":178,"funder":7,"programme":8,"title":179,"piName":14,"institution":169,"country":12,"year":13,"amount":180,"abstract":181},"cordis-european-research-council-award-210896","RNA and Epigenetics: RNAi-Driven Chromatin Modifications","€904,940","RNA interference (RNAi) mediates chromatin modifications in fungi, plants, drosophila and vertebrates. In the fission yeast Schizosaccharomyces pombe, where the molecular mechanisms are the most detailed, it is believed that small interfering RNAs (siRNAs) guide the RNA-Induced Transcriptional Silencing (RITS) complex to specific chromatin regions to trigger formation of heterochromatin. Although it is clear that siRNAs are required for RITS localization to chromatin, important events of RITS si",{"id":183,"funder":7,"programme":8,"title":184,"piName":14,"institution":185,"country":50,"year":13,"amount":186,"abstract":187},"cordis-european-research-council-award-240144","Three-Dimensional Surface Nano-Patterning: Concepts, Challenges and Applications","TECHNISCHE UNIVERSITAET ILMENAU","€1,398,600","Multifunctional surface nano-patterns on substrates are the foundation of semiconductor nano-devices. There is a major shortcoming of the existing surface nano-patterning techniques - in fact almost all synthesized surface patterns are two-dimensional (2-D) planar structures with low aspect ratio. Thus one of the most attractive advantages of nanomaterials, an extremely large surface area, is missing in the existing 2-D surface nano-patterns. This largely limits the application potential of surf",{"id":189,"funder":7,"programme":8,"title":190,"piName":14,"institution":25,"country":26,"year":13,"amount":191,"abstract":192},"cordis-european-research-council-award-240524","Understanding high-temperature superconductivity from the foundations: Superconductivity as a cure of bad metallic behaviour","€1,000,000","The origin of high-temperature superconductivity is definitely one of the most elusive topics in modern solid-state physics. The twenty years that followed the discovery of unprecentedly high critical temperatures in copper oxides have been dominated by a dychotomy between the standard",{"id":194,"funder":7,"programme":8,"title":195,"piName":14,"institution":196,"country":26,"year":13,"amount":197,"abstract":198},"cordis-european-research-council-award-241184","Interactive edition and interpretation of various works by Stoic and Epicurean philosophers surviving at Herculaneum","CONSIGLIO NAZIONALE DELLE RICERCHE","€900,000","The aim of this project is to provide through an innovative critical edition the first comprehensive interpretation of some physical, epistemological, ethical and rhetorical works by key figures of Hellenistic philosophy like Epicurus, Chrysippus and Philodemus. These works, totally lost in the manuscript tradition, are preserved exclusively in the carbonised papyrus rolls found since 1752 at Herculaneum and are either totally unpublished or were published only partially between the XIX and the ",{"id":200,"funder":7,"programme":8,"title":201,"piName":14,"institution":202,"country":80,"year":13,"amount":203,"abstract":204},"cordis-european-research-council-award-241009","The Earth Under Surveillance. Climate Change, Geophysics and the Cold War Legacy","THE UNIVERSITY OF MANCHESTER","€1,367,750","The development of geophysics of the last century has become more relevant to contemporary research. This is because much of the data accumulated in the past have allowed mapping many features of the Earth. Thanks to this information scientists can now appreciate long term changes in climate and environment. However, the data now available were not put together for this purpose. A big leap forward in geophysics materialised during the Cold War, when civilian and military research agencies promot",{"id":206,"funder":7,"programme":8,"title":207,"piName":14,"institution":208,"country":57,"year":13,"amount":209,"abstract":210},"cordis-european-research-council-award-240356","An Integrated Chemical Platform to Elucidate Eukaryotic Sensing of Bacterial Crosstalk","BEN-GURION UNIVERSITY OF THE NEGEV","€1,392,000","The term quorum sensing (QS) describes the ability of a population of unicellular bacteria to act as a single multicellular organism in a cell-density-dependent manner. Bacteria achieve this feat by the use of small diffusible molecules to exchange information among themselves. Examples of QS-controlled behaviors are bioluminescence, virulence factor expression and biofilm formation. These processes are advantageous to a bacterial population only when they are carried out simultaneously by its m",{"id":212,"funder":7,"programme":8,"title":213,"piName":14,"institution":214,"country":116,"year":13,"amount":215,"abstract":216},"cordis-european-research-council-award-239604","Integrated Theory and Observations of the Pleistocene","UNIVERSITE CATHOLIQUE DE LOUVAIN","€1,047,600","There are essentially two approaches to climate modelling. Over the past decades, efforts to understand climate dynamics have been dominated by computationally-intensive modelling aiming to include all possible processes, essentially by integrating the equations for the relevant physics. This is the bottom-up approach. However, even the largest models include many approximations and the cumulative effect of these approximations make it impossible to predict the evolution of climate over several ",{"id":218,"funder":7,"programme":8,"title":219,"piName":14,"institution":214,"country":116,"year":13,"amount":220,"abstract":221},"cordis-european-research-council-award-243188","Glycolytic contribution to cancer growth and metastasis","€1,493,320","Cancer lethality is most often associated to occurrence of distant metastases. To grow and become aggressive, cancers may undergo 2 critical adaptations: the glycolytic switch, corresponding to uncoupling glycolysis from the tricarboxylic acid (TCA) cycle, and the angiogenic switch, promoting neovascularization. In this high risk\u002Fhigh gain research program, we propose that the glycolytic switch precedes and promotes angiogenesis and metastatic dissemination in most types of cancer. We further en",{"id":223,"funder":7,"programme":8,"title":224,"piName":14,"institution":225,"country":44,"year":13,"amount":68,"abstract":226},"cordis-european-research-council-award-240080","DNA Block Copolymers: New Architectures and Applications","RIJKSUNIVERSITEIT GRONINGEN","With our contributions to DNA block copolymers (DBCs), we have opened a new field of interdisciplinary research at the intersection of polymer chemistry, biology and nanoscience. Within this proposal, we intend to apply our expertise with linear DBCs to new nucleocopolymer architectures ranging from star polymers to DNA networks. Our efforts will not only explore new covalently-bonded polymer topologies but also extend the range of self-assembled supramolecular structures accessible with DBCs. C",{"id":228,"funder":7,"programme":8,"title":229,"piName":14,"institution":230,"country":116,"year":13,"amount":231,"abstract":232},"cordis-european-research-council-award-241426","The biological role of tandem repeats as hypervariable modules in genomes","VIB VZW","€1,753,527","Living organisms change and evolve because of mutations in their DNA. Recent findings suggest that some DNA sequences are hypervariable and evolvable , while others are extremely robust and remain constant over evolutionary timescales. The long-term goal of our research is to combine theory and experiments to investigate the molecular mechanisms underlying genetic robustness and evolvability. Apart from the fundamental aspects, we also plan to explore practical facets, including swift evolution ",{"id":234,"funder":7,"programme":8,"title":235,"piName":14,"institution":236,"country":50,"year":13,"amount":14,"abstract":237},"cordis-european-research-council-award-200699","New Migrant Socialities: Ethnic Club Cultures in Urban Europe","JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN","The project investigates new forms of sociality that young people with migrant background are producing in the context of urban club cultures in three European cities. It comparatively studies the phenomenon of ethnic club scenes with Turkish, South Asian and Maghrebi orientations in Berlin, London and Paris, corresponding to the major immigrant groups in each city and country. The project aims to explore how migrants participate in forms of social engagement and cultural experimentation that ar",{"id":239,"funder":7,"programme":8,"title":240,"piName":14,"institution":241,"country":44,"year":13,"amount":242,"abstract":243},"cordis-european-research-council-award-241344","Morphostasis of the intestinal mucosa and it's deregulation in cancer and inflammation","ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM","€1,524,462","Stem cells at the base of the intestinal crypts are in a dynamic equilibrium with their differentiated derivatives. Homeostatic equilibria depend on the presence of negative feedback loops. The role of the Wnt signaling pathway as a driver of epithelial stem cell self renewal and proliferation in the intestine has been relatively well characterized. Much less is known about the negative feedback signals that must exist to control stem cell behavior and the way these may be deregulated in disease",{"id":245,"funder":7,"programme":8,"title":246,"piName":14,"institution":247,"country":99,"year":13,"amount":248,"abstract":249},"cordis-european-research-council-award-239834","Understanding the Atomic Scale Synergies of Catalytically Active Nanoclusters on Metal Oxide Surfaces","AARHUS UNIVERSITET","€1,050,000","The research theme concerns the application of new experimental methods for atomic-scale characterization of model catalysts based on insulating metal oxides with the goal of exploring the potential for designing new and efficient heterogeneous catalysts by enhanced control of the catalyst structure at the atomic level. This objective will be achieved by a carefully integrated sequence of synthesis, characterization, and reactivity measurements of model catalysts based on insulating metal oxides",{"id":251,"funder":7,"programme":8,"title":252,"piName":14,"institution":253,"country":254,"year":13,"amount":255,"abstract":256},"cordis-european-research-council-award-242551","Switch recombination: a model system for DNA editing and repair in human lymphocytes with relevance for primary immunodeficiency and cancer formation","KAROLINSKA INSTITUTET","SE","€1,888,166","The aim of this project is to try to understand the complex molecular mechanisms involved in DNA editing, repair and recombination during immunoglobulin class switch recombination (CSR) and somatic hypermutation (SHM). We have developed a series of PCR-based assays to study in vivo generated CSR junctions and the pattern of mutations introduced in the immunoglobulin variable region genes in human B cells, allowing us to characterize CSR and SHM in patients with immunodeficiency due to defect(s) ",{"id":258,"funder":7,"programme":8,"title":259,"piName":14,"institution":260,"country":261,"year":13,"amount":262,"abstract":263},"cordis-european-research-council-award-207777","Hypercapnic Acidosis and NF-kB in Ventilator Induced Lung Injury: Developing strategies to minimize lung injury and facilitate repair","UNIVERSITY OF GALWAY","IE","€1,052,556","Acute Respiratory Distress Syndrome and Acute Lung Injury [ALI\u002FARDS] are devastating diseases, causing over 20,000 deaths annually in the US. Mechanical ventilation may worsen ALI\u002FARDS, a process termed Ventilator Induced Lung Injury [VILI]. Hypercapnic acidosis (HA) is a central component of lung ventilatory strategies to minimize VILI, and is a potent biologic agent, exerting a myriad of effects on diverse biologic pathways. Deliberately induced HA is protective in multiple lung injury models.",{"id":265,"funder":7,"programme":8,"title":266,"piName":14,"institution":267,"country":44,"year":13,"amount":268,"abstract":269},"cordis-european-research-council-award-242958","Mechanisms of Wnt Signaling Initiation","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","€1,513,800","Wnt proteins dictate critical cell growth and lineage decisions during development and in adult tissue homeostasis. Inappropriate activation of Wnt signalling is a frequent cause of cancer. The earliest events that occur after Wnts bind their receptors at the cell surface, such as receptor endocytosis and recruitment of cytoplasmic effectors, are decisive for downstream gene activation but the underlying mechanisms by which these events process and tune the Wnt signal remain poorly understood. T",{"id":271,"funder":7,"programme":8,"title":272,"piName":14,"institution":267,"country":44,"year":13,"amount":273,"abstract":274},"cordis-european-research-council-award-242617","Guarding Genome Stability: Dynamic Control of Chromosome Segregation by Kinetochore Signalling Pathways","€1,572,000","Equal segregation of chromosomes during cell division is vital to all life. Using a unique combination of cell biological and biochemical techniques, I will show how an essential set of enzymes promotes error-free chromosome segregation. During each cell division, genetically identical daughter cells are generated by accurate partitioning of the duplicated chromosomes. This relies on proper spatio-temporal execution of various highly dynamic processes. The activity of a small group of enzymes is",{"id":276,"funder":7,"programme":8,"title":277,"piName":14,"institution":278,"country":279,"year":13,"amount":280,"abstract":281},"cordis-european-research-council-award-239739","Under the light of electrons","UNIVERSIDAD COMPLUTENSE DE MADRID","ES","€1,700,000","Here, we propose to explore and characterize new emerging phenomena in low dimensional (LD) and artificially structured oxide based systems by means of advanced electron microscopy techniques. Complex oxides have a large range of applications, since their properties change drastically as their precise composition and structure changes. When obtained in LD configurations new functionalities arise which are of fundamental interest in electronics, spintronics, energy or nanophotonics. We will use a",{"id":283,"funder":7,"programme":8,"title":284,"piName":14,"institution":285,"country":20,"year":13,"amount":286,"abstract":287},"cordis-european-research-council-award-240317","Network Coding for Wireless Networks","ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE","€1,771,520","Our goal is to develop fundamentally new architectures for wireless networks that offer the convenience of wireless communication while achieving the performance, predictability and security of wired networks. The wireless channel is inherently a shared medium characterized by limited resources and complex signal interactions between transmitted signals. The question we address is how do we transmit information over wireless and how do we exploit the wireless channel properties to share its reso",{"id":289,"funder":7,"programme":8,"title":290,"piName":14,"institution":285,"country":20,"year":13,"amount":291,"abstract":292},"cordis-european-research-council-award-243016","Protein assembly: From the molecular scale to the mesoscale with super-resolution imaging","€1,542,518","Cellular responses to external signals begin at the plasma membrane, where the dynamic assembly of receptors can regulate cellular activity. Membrane-enveloped viruses, including the human immunodeficiency virus (HIV) also assemble at the plasma membrane, exploiting mechanisms evolved for cellular trafficking. However, our physical paradigm for how proteins form mesoscale assemblies is far from complete. While the organization and dynamics of membrane proteins are heterogeneous, commonly used fl",{"id":294,"funder":7,"programme":8,"title":295,"piName":14,"institution":296,"country":116,"year":13,"amount":297,"abstract":298},"cordis-european-research-council-award-240980","Strengthening the European Court of Human Rights: More Accountability Through Better Legal Reasoning","UNIVERSITEIT GENT","€1,370,000","Human rights are under pressure, in Europe as elsewhere, due to several developments, namely [1] War on terror: the pressures generated by competing discourses [2] Coping with the dangers of rights inflation [3] Conflicting rights: how to handle rights as contested claims [4] The challenges of dealing with universality under fire In this context, the human rights leadership of the European Court of Human Rights is of crucial importance. Yet the Court is not fit for purpose. Inconsistencies and s",{"id":300,"funder":7,"programme":8,"title":301,"piName":14,"institution":302,"country":99,"year":13,"amount":303,"abstract":304},"cordis-european-research-council-award-239807","Surfaces, 3-manifolds and automorphism groups","KOBENHAVNS UNIVERSITET","€724,992","The scientific goal of the proposal is to answer central questions related to diffeomorphism groups of manifolds of dimension 2 and 3, and to their deformation invariant analogs, the mapping class groups. While the classification of surfaces has been known for more than a century, their automorphism groups have yet to be fully understood. Even less is known about diffeomorphisms of 3-manifolds despite much interest, and the objects here have only been classified recently, by the breakthrough wor",{"id":306,"funder":7,"programme":8,"title":307,"piName":14,"institution":302,"country":99,"year":13,"amount":14,"abstract":308},"cordis-european-research-council-award-242905","DNA repair factories how cells do biochemistry","The integrity of a cell's genome is constantly challenged by DNA lesions such as base modifications and DNA strand breaks. A single double-strand break is lethal if unrepaired and may lead to loss-of-heterozygosity, mutations, deletions, genomic rearrangements and chromosome loss if repaired improperly. Such genetic alterations are the main cause of cancer and other genetic diseases. Homologous recombination is an error-free pathway for repairing DNA lesions such as single- and double-strand bre",{"id":310,"funder":7,"programme":8,"title":311,"piName":14,"institution":312,"country":26,"year":13,"amount":313,"abstract":314},"cordis-european-research-council-award-241176","The origins and development of the human mirror neuron system","UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA","€1,208,400","Evidence demonstrating the presence of mirror neurons in the adult human brain has led many researchers to suggest a fundamental role for the mirror neuron system (MNS) in human mentalizing behavior and social cognition. Recent findings have also suggested strong relationships between MNS impairments and neurodevelopmental disorders in which mentalizing behavior is impaired. In light of this evidence, it has become of paramount importance to understand whether or not the MNS is present at birth ",{"id":316,"funder":7,"programme":8,"title":317,"piName":14,"institution":318,"country":261,"year":13,"amount":14,"abstract":319},"cordis-european-research-council-award-240809","The Limits of Demobilization, 1917-1923: Paramilitary Violence in Europe and the Wider World","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","The purpose of the proposed project is to think afresh about the violent aftermath of the Great War and its legacies. This will be achieved by forging a team of researchers who focus on the violent conflicts that erupted in many of the former combatant states after 1917\u002F18 from a comparative or transnational global perspective and the ways in which these conflicts were avoided in other areas. The project will differ from previous attempts to analyse the violent transition from war to peace in th",{"id":321,"funder":7,"programme":8,"title":322,"piName":14,"institution":323,"country":279,"year":13,"amount":324,"abstract":325},"cordis-european-research-council-award-240117","Cosmological Physics with future large-scale structure surveys","UNIVERSITAT DE BARCELONA","€1,395,000","Future, large galaxy surveys (such as BOSS, DES, LSST, EUCLID, ADEPT etc.) will cover of the order of 10000 square degrees on the sky, with the primary science goal to unravel the nature of the physics responsible for the current accelerated expansion of the universe. This acceleration likely involves new physics which could imply ether a modification of our understanding of particles and fields (if the acceleration is caused by a new negative pressure-component) or a change in our understanding",{"id":327,"funder":7,"programme":8,"title":328,"piName":14,"institution":323,"country":279,"year":13,"amount":329,"abstract":330},"cordis-european-research-council-award-241070","The Last Song of the Troubadours: Linguistic Codification and Construction of a Literary Canon in the Crown of Aragon (14th and 15th centuries)","€436,200","This project aims at the edition, study and interpretation of the troubadour poetry written in the Crown of Aragon between the 14th and 15th centuries, with special attention to its reception by a learned public of connoisseurs haunted by the myth of courtly love and its associated culture in the late medieval period. While Italy, France and the rest of the Iberian Peninsula were already moving towards Humanism, in the Crown of Aragon the prestige of the poetic universe created by the troubadour",{"id":332,"funder":7,"programme":8,"title":333,"piName":14,"institution":334,"country":26,"year":13,"amount":335,"abstract":336},"cordis-european-research-council-award-239898","DYNAMIC COVALENT CAPTURE: Dynamic Chemistry for Biomolecular Recognition and Catalysis","UNIVERSITA DEGLI STUDI DI PADOVA","€1,400,000","Molecular recognition plays a fundamental role in nearly all chemical and biological processes. The objective of this research project is to develop new methodology for studying and utilizing the noncovalent recognition between two molecular entities, focussing on biomolecular receptors and catalysts. A dynamic covalent capture strategy is proposed, characterized by the following strongholds. The target itself self-selects the best component out of a combinatorial library. The approach has a ver",{"id":338,"funder":7,"programme":8,"title":339,"piName":14,"institution":340,"country":80,"year":13,"amount":341,"abstract":342},"cordis-european-research-council-award-240449","Laboratory and modelling studies of ice nucleation and crystallisation in the Earth's atmosphere","UNIVERSITY OF LEEDS","€1,664,190","The formation of ice particles in the Earth s atmosphere strongly affects the properties of clouds and their impact on climate. However, our basic understanding of ice nucleation and crystallisation is still in its infancy. Despite the importance of ice formation in determining the properties of clouds, the Intergovernmental Panel on Climate Change (IPCC) was unable to assess the impact of atmospheric ice formation in their most recent report, because our basic knowledge is insufficient. In this",{"id":344,"funder":7,"programme":8,"title":345,"piName":14,"institution":346,"country":254,"year":13,"amount":347,"abstract":348},"cordis-european-research-council-award-200971","The Design of International Institutions: Legitimacy, Effectiveness and Distribution in Global Governance","STOCKHOLMS UNIVERSITET","€1,651,200","One of the most profound trends in global governance over the past two decades is the growing extent to which international institutions offer mechanisms for the participation of transnational actors. This project will explore two central research questions, pertaining to the causes and effects of this shift in the design of international institutions: (1) Why have international institutions increasingly opened up to transnational actor involvement? (2) What are the consequences of involving tra",{"id":350,"funder":7,"programme":8,"title":351,"piName":14,"institution":352,"country":20,"year":13,"amount":353,"abstract":354},"cordis-european-research-council-award-240518","Mathematical Aspects of Quantum Dynamics","University of Zurich","€750,000","The main goal of this proposal is to reacha better mathematical understanding ofthe dynamics of quantum mechanicalsystems. In particular I plan to workon the following three projects alongthis direction. A. Effective EvolutionEquations for Macroscopic Systems.The derivation of effective evolutionequations from first principle microscopictheories is a fundamental task of statisticalmechanics. I have been involved inseveral projects related to the derivationof the Hartree and the Gross-Piteavskiie",{"id":356,"funder":7,"programme":8,"title":357,"piName":14,"institution":358,"country":80,"year":13,"amount":14,"abstract":359},"cordis-european-research-council-award-243140","Temperature perception and signal transduction in plants","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","We seek to understand how plants perceive temperature. Being sessile organisms, plants are acutely sensitive to changes in ambient temperature, and are able to detect and respond to a change of as little as one degree Celsius. To directly address how plants sense temperature change, we have devised and implemented a novel forward genetic screen for mutants impaired in their ability to detect temperature correctly. Initial results demonstrate an interesting connection between chromatin structure ",{"id":361,"funder":7,"programme":8,"title":362,"piName":14,"institution":358,"country":80,"year":13,"amount":363,"abstract":364},"cordis-european-research-council-award-242664","Chromatin Mediators of Estrogen Receptor Biology","€1,500,345","Estrogen Receptor (ER) drives proliferation in breast cancers and drugs such as tamoxifen and Aromatase Inhibitors, that target ER activity, are first line treatments in clinical practice. However drug resistance is a significant clinical problem. My laboratory has reported that chromatin-modifying pioneer factors are required for ER to bind the genome, and may constitute a unique opportunity for treating drug resistant cancer. My proposal consists of two complementary approaches to comprehensiv",{"id":366,"funder":7,"programme":8,"title":367,"piName":14,"institution":358,"country":80,"year":13,"amount":280,"abstract":368},"cordis-european-research-council-award-240629","Aqueous Supramolecular Polymers and Peptide Conjugates in Reversible Systems","Supramolecular polymers are of major interest in the field of self assembly with a promising outlook in areas of viscosity modification, compartmentalized architectures, bio-conjugates and drug-delivery applications. They are dynamic macromolecular materials prepared by simple mixing of relatively small components bearing complementary or self-complementary recognition motifs. A major limitation in the field, however, has been access to synthetic systems capable of undergoing self assembly in an",{"id":370,"funder":7,"programme":8,"title":371,"piName":14,"institution":372,"country":50,"year":13,"amount":373,"abstract":374},"cordis-european-research-council-award-240335","Exploring hybrid quantum systems of ultracold atoms and ions","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","€1,405,000","We propose to investigate hybrid quantum systems composed of ultracold atoms and ions. The mutual interaction of the cold neutral atoms and the trapped ion offers a wealth of interesting new physical problems. They span from ultracold quantum chemistry over new concepts for quantum information processing to genuine quantum many-body physics. We plan to explore aspects of quantum chemistry with ultracold atoms and ions to obtain a full understanding of the interactions in this hybrid system. We w",{"id":376,"funder":7,"programme":8,"title":377,"piName":14,"institution":378,"country":50,"year":13,"amount":379,"abstract":380},"cordis-european-research-council-award-204034","Mechanisms of myelin biogenesis and repair","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€1,290,000","During the development of the central nervous system, specialized glia, oligodendrocytes, extend and wrap their plasma membrane around axons to form tightly packed membrane stacks that provide electrical insulation. Axonal insulation by myelin facilitates rapid nerve conduction and is essential for neuronal metabolism. Damage to the myelin sheath as it for example occurs in multiple sclerosis results in severe neurological disability not only by slowing down nerve conduction, but also as a resul",{"id":382,"funder":7,"programme":8,"title":383,"piName":14,"institution":378,"country":50,"year":13,"amount":280,"abstract":384},"cordis-european-research-council-award-242635","Making Sense of Metagenomes","Microorganisms are the greatest chemists of our planet. Almost every chemical reaction that is thermodynamically feasible is exploited by these organisms to sustain growth and survival. Together, the actions of microbes comprise the biogeochemical element cycles, a vastly complicated metabolic network that is the basis of all life. Since a few years the metagenomic exploration of this network has begun. Ten years from now next-generation massive parallel sequencing technology will enable the cos",{"id":386,"funder":7,"programme":8,"title":387,"piName":14,"institution":388,"country":50,"year":13,"amount":389,"abstract":390},"cordis-european-research-council-award-242933","Biomolecular Motor Systems: From Cellular Function to Nanotechnological Applications","TECHNISCHE UNIVERSITAET DRESDEN","€1,956,000","This interdisciplinary project aims (i) to understand intracellular transport processes on a molecular level using novel nano-optical imaging tools and (ii) to use the insight from cellular systems to operate biomolecular motor systems in engineered environments for the fulfillment of complex nanotechnological tasks. Building on experience in optical microscopy and single molecule biophysics the research group will develop and apply nanotechnology-based tools to study the dynamical functioning o",{"id":392,"funder":7,"programme":8,"title":393,"piName":14,"institution":394,"country":395,"year":13,"amount":396,"abstract":397},"cordis-european-research-council-award-208132","Understanding computational roles of new neurons generated in the adult hippocampus","NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU","NO","€1,991,743","New neurons are continuously generated in certain regions of adult mammalian brain. One of those regions is the dentate gyrus, a subregion of hippocampus, which is essential for memory formation. Although these new neurons in the adult dentate gyrus are thought to have an important role in learning and memory, it is largely unclear how new neurons are involved in information processing and storage underlying memory. Because new neurons constitute a minor portion of intermingled local neuronal po",{"id":399,"funder":7,"programme":8,"title":400,"piName":14,"institution":296,"country":116,"year":13,"amount":147,"abstract":401},"cordis-european-research-council-award-240865","The Mamlukisation of the Mamluk Sultanate. Political Traditions and State Formation in 15th century Egypt and Syria","I aim to radically reconsider standard views of late medieval Islamic history. Positing that prosopographical research will allow for a welcome reconstruction of the political traditions that dominated the Syro-Egyptian Mamluk sultanate in the 15th century, I endeavour to show how new traditions emerged that were constructed around the criterion of military slavery, and how this actually reflects a process of state formation, which puts this regime on a par with emerging European states.Mamluk h",{"id":403,"funder":7,"programme":8,"title":404,"piName":14,"institution":405,"country":80,"year":13,"amount":406,"abstract":407},"cordis-european-research-council-award-239870","Stochastic and Multiscale Modelling in Biology","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€624,999","I will create a research team in applied mathematics which will work on development and analysis of methods for stochastic and multiscale modelling of biological systems. This research project is divided into three core areas: (A) development of stochastic simulation algorithms for reaction-diffusion processes; (B) analysis of (bio)chemical reaction systems using the chemical Fokker-Planck equation and multiscale  computational approaches; (C) understanding the collective behaviour of systems of",{"id":409,"funder":7,"programme":8,"title":410,"piName":14,"institution":411,"country":80,"year":13,"amount":412,"abstract":413},"cordis-european-research-council-award-240123","Gromov-Witten Theory: Mirror Symmetry, Modular Forms, and Integrable Systems","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€620,000","The Gromov-Witten invariants of a space X record the number of curves in X of a given genus and degree which meet a given collection of cycles in X. They have important applications in algebraic geometry, symplectic geometry, and theoretical physics. The program proposed here will allow us to compute Gromov-Witten invariants, and particularly higher-genus Gromov-Witten invariants, for a very broad class of spaces. Recent progress, partly due to the Principal Investigator, has led to a greatly-im",{"id":415,"funder":7,"programme":8,"title":416,"piName":14,"institution":411,"country":80,"year":13,"amount":14,"abstract":417},"cordis-european-research-council-award-242991","Optical Platform for Therapy and diagnostic Imaging in Minimally Invasive Surgical Endoscopy","With the clinical drive for earlier detection of disease and minimally invasive treatment, there is a paradigm shift of imaging and therapy towards in vivo, in situ surgery. One major effort towards this goal is the translation of emerging optical diagnostic imaging and therapy techniques into minimally invasive surgery (MIS) and cancer screening. This proposal will develop a novel multimodal platform that can be deployed in flexible endoscopy and robotic assisted MIS devices. This is timely in ",{"id":419,"funder":7,"programme":8,"title":420,"piName":14,"institution":421,"country":50,"year":13,"amount":422,"abstract":423},"cordis-european-research-council-award-243256","ATP dependent nucleosome remodelling - Single molecule studies and super-resolution microscopy","UNIVERSITAET ULM","€1,395,381","In eukaryotic cells the DNA is packaged into nucleosomes and higher order structures which lead to a condensation and protection of the DNA. During important cellular processes such as transcription or replication access to the DNA has to be granted. This is facilitated by ATP dependent nucleosome remodelling. The mechanistic details how the involved remodelling complexes succeed in providing access to the nucleosomal DNA are currently in spite of large experimental efforts not well understood. ",{"id":425,"funder":7,"programme":8,"title":426,"piName":14,"institution":427,"country":50,"year":13,"amount":14,"abstract":428},"cordis-european-research-council-award-241506","Persistence of allergic sensitization","UNIVERSITATSKLINIKUM ERLANGEN","Allergic disorders are dramatically increasing in the western world over the past several years. Allergies are inappropriate immune responses directed against harmless environmental antigens. Upon primary allergen encounter B cells are induced to differentiate into IgE producing plasma cells. Mast cells and basophils are then sensitized by binding of allergen-specific IgE molecules to the high-affinity IgE receptor on the cell surface. A second allergen exposure causes cross-linking of IgE molec",{"id":430,"funder":7,"programme":8,"title":431,"piName":14,"institution":432,"country":20,"year":13,"amount":433,"abstract":434},"cordis-european-research-council-award-243344","From neurons to behavior: analysis of the mechanisms underlying sensory coding and plasticity in chemical senses","UNIVERSITE DE GENEVE","€1,399,998","How sensory processing is occurring into the brain and how to relate behavior to neuronal activities are key questions in modern neuroscience. Understanding the neural codes underlying brain function will be of great importance for future implementation of brain-machine interfaces. This research project proposes to study the cellular and network mechanisms controlling sensory perception. In particular, we would like to precise how sensory stimuli are coded by brain networks and how these represe",{"id":436,"funder":7,"programme":8,"title":437,"piName":14,"institution":285,"country":20,"year":13,"amount":438,"abstract":439},"cordis-european-research-council-award-243182","Novel tools for real time monitoring and quantification of protein aggregation in Parkinson s disease and related neurodegenerative disorders","€1,495,400","To understand the molecular basis of any biological process, it is critical that one is not only able to visualize and monitor molecular events that underlie this process, but also to possess the tools to manipulate these events in a spatial and temporal fashion both in and out of the cell. The overall objective of this proposal is to apply chemical biology approaches to allow real time monitoring of protein aggregation and to dissect the role of specific disease-associated post-translational mo",{"id":441,"funder":7,"programme":8,"title":442,"piName":14,"institution":285,"country":20,"year":13,"amount":443,"abstract":444},"cordis-european-research-council-award-240076","Electronic devices based on nanolayers","€1,799,996","The main objective of this research proposal is to explore the electrical properties of nanoscale devices and circuits based on nanolayers.  Nanolayers cover a wide span of possible electronic properties, ranging from semiconducting to superconducting. The possibility to form electrical circuits by varying their geometry offers rich research and practical opportunities. Together with graphene, nanolayers could form the material library for future nanoelectronics where different materials could b",{"id":446,"funder":7,"programme":8,"title":447,"piName":14,"institution":285,"country":20,"year":13,"amount":448,"abstract":449},"cordis-european-research-council-award-243128","Tie2-expressing monocytes: Role in tumor angiogenesis and therapeutic targeting","€1,311,900","Recent data indicated that tumor-infiltrating myeloid cells promote tumor angiogenesis. We contributed to this concept by showing that Tie2-expressing monocytes (TEMs) have a requisite role in this process. Indeed, the specific elimination of TEMs inhibits tumor angiogenesis and growth in several models. Yet, little is known of the biological bases of TEMs activity in tumors. Building upon my previous studies, I will provide a thorough characterization of the precise identity of TEMs and of thei",{"id":451,"funder":7,"programme":8,"title":452,"piName":14,"institution":285,"country":20,"year":13,"amount":280,"abstract":453},"cordis-european-research-council-award-239831","A Universal Supramolecular Approach toward Organic Electronic Materials and Nanostructured Carbonaceous Materials from Molecular Precursors","Research in novel energy sources, efficient energy storage, sustainable chemical technology, and smaller microelectronic devices with interfaces for biological systems are among the current challenges in science and technology. Carbonaceous materials and organic electronic materials which speak the language of biomaterials will play a central role in the search for possible solutions. We aim to develop a universal supramolecular approach for their preparation and propose to develop synthetic pat",{"id":455,"funder":7,"programme":8,"title":456,"piName":14,"institution":285,"country":20,"year":13,"amount":457,"abstract":458},"cordis-european-research-council-award-240332","Uncovering the origins of friction","€1,773,000","Nanotechnology is a new frontier in research and new tools must be developed. As surface to volume ratios become large, engineering at the nanoscale will be dominated by surface science. The study of Contact Mechanics at nanoscales nanotribology- needs to fully account for adhesive forces, third-body interactions and deformation mechanisms at contacting asperities. Understanding these factors as well as the morphological evolution of contact clusters has the potential of explaining the origins o",{"id":460,"funder":7,"programme":8,"title":461,"piName":14,"institution":285,"country":20,"year":13,"amount":14,"abstract":462},"cordis-european-research-council-award-240556","Molecular Interfacial structure and dynamics of Nanoscopic droplets in Emulsions (MINE)","Emulsions consist of one liquid dispersed as nanoscopic droplets in another liquid, such as milk, and butter. The understanding of the structure and stability of emulsions is commonly obtained from empirical studies in which a macroscopic parameter (like temperature or concentration of constituents) is varied. Since the work of Irving Langmuir and others (published in 1917) it is well established that the stability and properties of these nanoscopic droplets are strongly influenced by the state ",{"id":464,"funder":7,"programme":8,"title":465,"piName":14,"institution":466,"country":57,"year":13,"amount":335,"abstract":467},"cordis-european-research-council-award-239603","Sophisticated Well-Targeted Therapeutic Entities based on Biologically Compatible Ti(IV) Active Cores and Building Blocks","THE HEBREW UNIVERSITY OF JERUSALEM","I propose to develop sophisticated anti-tumor agents targeted particularly to the location of activity. My team has recently introduced a new family of Ti(IV) complexes that demonstrates higher activity than known compounds with substantially higher stability and defined hydrolytic behavior, properties that were found to be essential. I propose to study various derivatives and identify the parameters affecting activity, including steric and electronic effects, enantiomeric purity, ligand labilit",{"id":469,"funder":7,"programme":8,"title":470,"piName":14,"institution":471,"country":57,"year":13,"amount":472,"abstract":473},"cordis-european-research-council-award-242763","SIRT6 activation for countering age-related metabolic diseases","BAR ILAN UNIVERSITY","€1,510,968","The significant increase in the human lifespan during the last century confronts us with great medical challenges. To answer them, one must understand and control the mechanisms that determine the rate of ageing. The sirtuins, and in particular the mammalian member SIRT6, are a family of NAD+ dependent deacetylases that were implicated in ageing and the regulation of metabolism. Much evidence correlates SIRT6 with the regulation of ageing, primarily the manifestation of ageing related pathologie",{"id":475,"funder":7,"programme":8,"title":476,"piName":14,"institution":471,"country":57,"year":13,"amount":14,"abstract":477},"cordis-european-research-council-award-239868","Large Scale Privacy-Preserving Technology in the Digital World - Infrastructure and Applications","Data mining provides large benefits to the commercial, government and homeland security sectors, but the aggregation and storage of huge amounts of data about citizens inevitably leads to erosion of privacy. To achieve the benefits that data mining has to offer, while at the same time enhancing privacy, we need technological solutions that simultaneously enable data mining while preserving privacy. The current state of the art has focused on providing privacy-preserving solutions for very specif",{"id":479,"funder":7,"programme":8,"title":480,"piName":14,"institution":481,"country":12,"year":13,"amount":482,"abstract":483},"cordis-european-research-council-award-243296","Integrative structure and function study of the bacterial and human protein synthesis machinery","CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE","€1,690,000","The aim of the project is to understand key steps in the molecular mechanisms of protein synthesis across species. The structure and function of pro- and eukaryotic (including human) ribosomes, those cellular nano-machineries that catalyse the decoding of genes, will be studied through an integrative, interdisciplinary structural biology approach. Since in the cell the ribosome is regulated by transiently binding protein and RNA factors, we plan the reconstitution and structural investigation of",{"id":485,"funder":7,"programme":8,"title":486,"piName":14,"institution":487,"country":12,"year":13,"amount":488,"abstract":489},"cordis-european-research-council-award-239781","Legendrian contact homology and generating families","UNIVERSITE PARIS-SUD","€710,000","A contact structure on an odd dimensional manifold in a maximally non integrable hyperplane field. It is the odd dimensional counterpart of a symplectic structure. Contact and symplectic topology is a recent and very active area that studies intrinsic questions about existence, (non) uniqueness and rigidity of contact and symplectic structures. It is intimately related to many other important disciplines, such as dynamical systems, singularity theory, knot theory, Morse theory, complex analysis,",{"id":491,"funder":7,"programme":8,"title":492,"piName":14,"institution":493,"country":494,"year":13,"amount":495,"abstract":496},"cordis-european-research-council-award-240830","Public Goods through Private Eyes. Exploring Citizens' Attitudes to Public Goods and the State in Central Eastern Europe","UNIWERSYTET WARSZAWSKI","PL","€1,730,000","Post-communist states of Central and Eastern Europe form a particularly challenging context for public goods production, due to the communist legacies as well as experiences of transformation. Drawing on theory and research available in political science, sociology and economics, this multi-disciplinary, comparative project will formulate and test an extensive model of public goods oriented behaviour and its determinants in the context of post-communist countries of CEE. The key objectives of th",{"id":498,"funder":7,"programme":8,"title":499,"piName":14,"institution":493,"country":494,"year":13,"amount":500,"abstract":501},"cordis-european-research-council-award-239850","Expressive Power of Tree Logics","€799,920","Logics for expressing properties of labeled trees and forests figure importantly in several different areas of Computer Science, including verification (branching temporal logics) and database theory (many XML query languages). The goal of this project is to investigate the expressive power of tree logics, mainly those logics that can be captured by tree automata. A similar study, but for word languages, is one of the main lines of research in formal language theory. The study of the expressive ",{"id":503,"funder":7,"programme":8,"title":504,"piName":14,"institution":505,"country":50,"year":13,"amount":506,"abstract":507},"cordis-european-research-council-award-243195","Keratinocytes and Matrix metalloproteinases: driving force of skin wound contraction?","UNIVERSITAET BREMEN","€1,299,840","Two unconventional concepts of skin contraction are presented that could change the current paradigm of wound healing. The overall objective is to clarify the underlying processes and to develop new therapies to prevent excessive scarring, ameliorate patients lives and reduce medical health care expenses. Specific emphasis lies on the role of Matrix metalloproteinases (MMP) and keratinocytes. Previous internationally acknowledged work of the PI resulted in these challenging concepts. The project",{"id":509,"funder":7,"programme":8,"title":510,"piName":14,"institution":505,"country":50,"year":13,"amount":511,"abstract":512},"cordis-european-research-council-award-205509","Bioceramics: Multiscale Engineering of Advanced Ceramics at the Biology Interface","€1,536,120","In the last decades, Materials Sciences and Life Sciences, two highly dynamically evolving and interdisciplinary research areas, have been influencing natural and engineering sciences significantly, creating new challenges and opportunities. A prime example for an increasing synergetic overlap of Materials and Life Sciences is provided by biomedical and bioengineering applications, which are of great academic, but also of steadily increasing societal and commercial interest. Bridging the traditi",{"id":514,"funder":7,"programme":8,"title":515,"piName":14,"institution":352,"country":20,"year":13,"amount":516,"abstract":517},"cordis-european-research-council-award-243047","Revealing the molecular architecture of integrin mediated cell adhesion","€1,294,000","Cell adhesions play an important role in the organization, growth, maturation, and function of living cells. Interaction of cells with the extracellular matrix (ECM) plays an essential role in a variety of disease states , inflammation, and repair of damaged tissues. At the cellular level, many of the biological responses to external stimuli originate at adhesion loci, such as focal adhesions (FA), which link cells to the ECM . Cell adhesion is mediated by receptor proteins such as cadherins and",{"id":519,"funder":7,"programme":8,"title":520,"piName":14,"institution":521,"country":26,"year":13,"amount":353,"abstract":522},"cordis-european-research-council-award-202781","Galaxies through the cosmic ages: the role of primordial conditions and environmental effects","ISTITUTO NAZIONALE DI ASTROFISICA","The observed properties of galaxies have long been known to depend on the environment in which they are located. The physical origin of the observed environmental trends is, however, still a subject of debate. Much of the argument centres on whether these trends are the end products of physical processes acting over the entire lifetime of a galaxy (the nurture hypothesis), or whether they are established at formation (the nature hypothesis). One element is often overlooked in this debate: accord",{"id":524,"funder":7,"programme":8,"title":525,"piName":14,"institution":526,"country":12,"year":13,"amount":527,"abstract":528},"cordis-european-research-council-award-240007","EXPLORERS Exploring epigenetic robotics: raising intelligence in machines","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","€1,572,215","In spite of considerable work in artificial intelligence, machine learning, and pattern recognition in the past 50 years, we have no machine capable of adapting to the physical and social environment with the flexibility, robustness and versatility of a 6-months old human child. Instead of trying to simulate directly the adult s intelligence, EXPLORERS proposes to focus on the developmental principles that give rise to intelligence in infants by re-implementing them in machines. Framed in the de",{"id":530,"funder":7,"programme":8,"title":531,"piName":14,"institution":526,"country":12,"year":13,"amount":532,"abstract":533},"cordis-european-research-council-award-239993","Sparse Structured Methods for Machine Learning","€1,468,248","Machine learning is now a core part of many research domains, where the abundance of data has forced researchers to rely on automated information processing. In practice, today, machine learning techniques are applied in two stages: practitioners first build a large set of features; then, off-the-shelf algorithms are used to solve the appropriate prediction tasks, such as classification or regression. While this has led to significant advances in many domains, I believe that the potential of mac",{"id":535,"funder":7,"programme":8,"title":536,"piName":14,"institution":537,"country":158,"year":13,"amount":538,"abstract":539},"cordis-european-research-council-award-240453","Technologies and psychophysics of spatial sound","AALTO KORKEAKOULUSAATIO SR","€1,879,458","Spatial audio is a field, which investigates technologies to capture and reproduce sound in a way that the spatial properties of it are either preserved or modified depending on application. For example, modern surround sound techniques try to reproduce the sound scene perceived by a human listener in the same way than in the original occasion. The principal investigator (PI) has been able to develop a number of technologies in spatial audio field and to transfer them to the industry. The projec",{"id":541,"funder":7,"programme":8,"title":542,"piName":14,"institution":537,"country":158,"year":13,"amount":14,"abstract":543},"cordis-european-research-council-award-240970","Talent and Learning in Imperfect Markets","The overall effectiveness at which the underlying talent resources in an economy are utilized is an important determinant of long-run economic growth and well-being. Recent work has shown that the processes through which talent is discovered and revealed in the economy are likely to suffer from market imperfections that are analogous to problems that have been for long been understood in the context of private provision of job training and education, resulting in not just reduced economic effici",{"id":545,"funder":7,"programme":8,"title":546,"piName":14,"institution":547,"country":26,"year":13,"amount":147,"abstract":548},"cordis-european-research-council-award-240624","Electronic Structure of Chemical, Biochemical, and Biophysical Systems: Multiscale Approach with Electron Correlation","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","The currently available computational methods have often serious limitations to treat systems where electron correlation plays and important role. Many issues concerning the electronic structure of radicals, photoreceptors near-half-filled transition metals (Cr,Mo,Fe,Ni) are of paramount relevance in basic and applied research in Chemistry and Biochemistry, but still out of the capabilities of standard and conventional tools such as Density Functional Theory. On the other hand, post Hartree-Fock",{"id":550,"funder":7,"programme":8,"title":551,"piName":14,"institution":552,"country":80,"year":13,"amount":553,"abstract":554},"cordis-european-research-council-award-240473","An integrated geoscientific study of the thermodynamics and composition of the Earth's core-mantle interface","UNIVERSITY OF BRISTOL","€1,639,615","The core-mantle interface is the central cog in the Earth's titanic heat engine. As the boundary between the two major convecting parts of the Earth system (the solid silicate mantle and the liquid iron outer core) the properties of this region have a profound influence on the thermochemical and dynamic evolution of the entire planet, including tectonic phenomena at the surface. Evidence from seismology shows that D (the lowermost few hundred kilometres of the mantle) is strongly heterogeneous i",{"id":556,"funder":7,"programme":8,"title":557,"piName":14,"institution":552,"country":80,"year":13,"amount":558,"abstract":559},"cordis-european-research-council-award-240390","Integrated quantum photonics","€1,532,400","Quantum information science (QIS) promises fundamental insight into the workings of nature, as we gain mastery over single and coupled quantum systems, as well as a paradigm shift in information technologies. It is a pioneering field at the interface of the physical and information sciences of major international interest, with substantial investment in North America, Asia and Europe. The first quantum technology has just arrived: quantum cryptography systems are now being used commercially to p",{"id":561,"funder":7,"programme":8,"title":562,"piName":14,"institution":563,"country":80,"year":13,"amount":248,"abstract":564},"cordis-european-research-council-award-239988","Microscopic Modelling of Excitonic Solar Cell Interfaces","UNIVERSITY OF WARWICK","Organic Photovoltaic Solar Cells and Dyes Sensitized Solar Cells (collectively referred to as Excitonic Solar Cells) are one of the major alternatives to silicon photovoltaics and the subject of the proposed investigation. The PI s expertise in the theory of single molecule electron transport, organic electronics and condensed phase simulations will be used to build a research team that will investigate all elementary processes that take place at the interface of excitonic solar cells. For the f",{"id":566,"funder":7,"programme":8,"title":567,"piName":14,"institution":568,"country":44,"year":13,"amount":569,"abstract":570},"cordis-european-research-council-award-240433","Hybrid Inorganic-Organic NanoElectronics","UNIVERSITEIT TWENTE","€1,750,000","This project aims at combining inorganic and organic materials in hybrid nanoelectronic structures for addressing a set of key problems in solid-state physics: (1) the magnetic ordering of 2D spin systems and their interaction with conduction electrons, (2) the coherent transport properties of organic molecules, and (3) reliable electronic characterization of single nanostructures. For all objectives we will integrate top-down and bottom-up (self-assembly) techniques, benefitting from strong col",{"id":572,"funder":7,"programme":8,"title":573,"piName":14,"institution":574,"country":575,"year":13,"amount":576,"abstract":577},"cordis-european-research-council-award-241025","International Law and Non-liberal States: The Doctrine and Application of International Law in the Russian Federation","TARTU ULIKOOL","EE","€500,000","The central research question of our project is: what impact does the increasingly non-liberal orientation of the government of the Russian Federation have on the Russian doctrine and practice of international law? As the West and Russia hope to further build their relationship on international law, is it still the same international law that they are talking about? We aim to provide systematic empirical evidence on the use and conceptualization of international law in the Russian Federation. Bu",{"id":579,"funder":7,"programme":8,"title":580,"piName":14,"institution":581,"country":26,"year":13,"amount":582,"abstract":583},"cordis-european-research-council-award-242965","ALK as a common target for the pathogenesis and therapy in lymphoma, lung carcinoma and neuroblastoma","UNIVERSITA DEGLI STUDI DI TORINO","€1,010,000","The Anaplastic Lymphoma Kinase (ALK) has been discovered as the result of chromosomal translocations in Anaplastic Large Cell Lymphomas (ALCL) (Chiarle et al Nat Rev Cancer. 2008, 8:11). In ALCL, the role of the ALK oncogenic translocations has been established in vitro and in transgenic mouse models. Recent findings have shown ALK translocations, mutations or amplifications in other types of solid cancers, such as lung carcinoma (Soda et al. Nature. 2007, 448:561) and neuroblastoma (Mossè et al",{"id":585,"funder":7,"programme":8,"title":586,"piName":14,"institution":587,"country":254,"year":13,"amount":588,"abstract":589},"cordis-european-research-council-award-240603","Ab initio approach to nuclear structure and reactions (++)","CHALMERS TEKNISKA HOGSKOLA AB","€1,304,800","Today, much interest in several fields of physics is devoted to the study of small, open quantum systems, whose properties are profoundly affected by the environment; i.e., the continuum of decay channels. In nuclear physics, these problems were originally studied in the context of nuclear reactions but their importance has been reestablished with the advent of radioactive-beam physics and the resulting interest in exotic nuclei. In particular, strong theory initiatives in this area of research ",{"id":591,"funder":7,"programme":8,"title":592,"piName":14,"institution":593,"country":26,"year":13,"amount":594,"abstract":595},"cordis-european-research-council-award-240111","Assembly of Colloidal Nanocrystals into Unconventional Types of Nanocomposite Architectures with Advanced Properties","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","€1,299,960","Nanoscience promises innovative solutions in a large variety of sectors, ranging from cost-effective optoelectronic devices to energy generation, and to highly performing materials and interfaces. Realizing this promise will rely heavily on a bottom-up approach. This can only succeed if self assembly of advanced nanoscale building blocks will be developed intensively, to enable creation of useful macroscopic architectures. The unconventional assembly of nanocrystals towards functional materials ",{"id":597,"funder":7,"programme":8,"title":598,"piName":14,"institution":599,"country":80,"year":13,"amount":14,"abstract":600},"cordis-european-research-council-award-243019","Regulation and Function of Cullin-Ring E3 ubiquitin ligases and the Nedd8 ubiquitin-like protein modification system","UNIVERSITY OF DUNDEE","Cullin-RING E3 ubiquitin ligases (CRLs) are multi-subunit enzyme complexes that catalyze isopeptide bond formation between the C-terminal glycine residue of the small protein ubiquitin and lysine residues of substrate proteins (ubiquitination). Multiple rounds of ubiquitination lead to the formation of ubiquitin chains, which are recognized by the 26S-proteasome, a protease that degrades the substrates. Targeted protein degradation by CRLs is an important part of many essential cellular processe",{"id":602,"funder":7,"programme":8,"title":603,"piName":14,"institution":604,"country":80,"year":13,"amount":14,"abstract":605},"cordis-european-research-council-award-242666","From Environment to Physiology: Neuroendocrine Circuits and Genetic Mechanisms that Modulate Ageing and Development","KING'S COLLEGE LONDON","We seek to understand how organisms interpret complex environments to generate appropriate changes in their physiology. Specifically, we will focus on how food and temperature affect lifespan and a switch between reproductive growth versus a specialised developmental arrest (dauer) in C. elegans. Extensive work has indicated that the daf-2 insulin-like peptide (ILP) receptor plays a pivotal role in these processes, but key questions remain about how environmental inputs are linked to secretion o",{"id":607,"funder":7,"programme":8,"title":608,"piName":14,"institution":466,"country":57,"year":13,"amount":191,"abstract":609},"cordis-european-research-council-award-240263","Growth and Shaping of Soft Tissue","Many natural structures are made of soft tissue that undergoes complicated continuous shape transformations that accurately and reliably serve specific elaborate tasks. Such processes can be slow, as in growth of a tissue, leading from an initial, featureless, shape to the desired elaborate structure of the adult organ. In other cases continuous shape transformations of soft tissue are rapid and are used for the production of mechanical work, as in the case of the action of the hart. Our underst",{"id":611,"funder":7,"programme":8,"title":612,"piName":14,"institution":613,"country":44,"year":13,"amount":197,"abstract":614},"cordis-european-research-council-award-240602","Study of Terahertz Focal Plain Arrays","STICHTING SRON NETHERLANDS INSTITUTE FOR SPACE RESEARCH","The Terahertz frequency band is largely unexplored both for astronomical and for ground based applications. Over the recent years significant progress has been made in developing coherent detection techniques applicable at these higher frequencies, which enabled the building of array-receivers. When located in a focal plane a telescope such novel systems allow for a manifold increase in performance. However, the development of coherent detector focal plane arrays is still lagging behind. For inc",{"id":616,"funder":7,"programme":8,"title":617,"piName":14,"institution":618,"country":80,"year":13,"amount":147,"abstract":619},"cordis-european-research-council-award-240910","Research on Microeconometrics: Econometric Theory and Applications","Institute for Fiscal Studies","Recent years have witnessed a surge of international research in using micro-level data to answer empirical economic questions. This surge was possible because of the sharp increase in high-quality micro-level data across world, in particular in the US and Europe. The high-quality micro-level data are essential ingredients to understand economic behaviour and the impact of economic and social policy; however, having just the high-quality micro-level data is not sufficient to uncover the causal r",{"id":621,"funder":7,"programme":8,"title":622,"piName":14,"institution":623,"country":279,"year":13,"amount":624,"abstract":625},"cordis-european-research-council-award-239910","Bio-inspired Design of Catalysts for Selective Oxidations of C-H and C=C Bonds","UNIVERSITAT DE GIRONA","€1,299,998","The selective functionalization of C-H and C=C bonds remains a formidable unsolved problem, owing to their inert nature. Novel alkane and alkene oxidation reactions exhibiting good and\u002For unprecedented selectivities will have a big impact on bulk and fine chemistry by opening novel methodologies that will allow removal of protection-deprotection sequences, thus streamlining synthetic strategies. These goals are targeted in this project via design of iron and manganese catalysts inspired by struc",{"id":627,"funder":7,"programme":8,"title":628,"piName":14,"institution":629,"country":254,"year":13,"amount":630,"abstract":631},"cordis-european-research-council-award-242932","Cell and gene therapy based approaches for treatment of Parkinson's disease: from models to clinics","MAX IV Laboratory, Lund University","€1,508,940","Parkinson s disease is one of the common causes of disability in the aging population, representing a major health problem for the affected individuals and a socioeconomic burden to the society. In the present proposal, the applicant puts forward an ambitious but feasible program to tackle a number of significant issues that remain unsolved in the field. He combines his strong track record in animal models of Parkinson s disease and novel cell and gene therapy-based therapeutic strategies with p",{"id":633,"funder":7,"programme":8,"title":634,"piName":14,"institution":635,"country":279,"year":13,"amount":594,"abstract":636},"cordis-european-research-council-award-239582","Control of the Electronic Properties in Hybrid- Quantum Dot\u002FPolymer-Materials for Energy Production","FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA","The PolyDot project aims to foster necessary progress on frontier research that integrates a number of leading concepts in the field of photoelectrochemistry in association with new concepts from areas such as nanoscience and materials chemistry. As an example, key scientific elements of the PolyDot project are the synthesis of new molecular electronic components, such as semiconducting quantum dots, the design of self-organising functional interfaces through supramolecular interactions and the ",{"id":638,"funder":7,"programme":8,"title":639,"piName":14,"institution":640,"country":279,"year":13,"amount":641,"abstract":642},"cordis-european-research-council-award-240054","Novel Developments in Time Projection Chambers (TPCs) for Rare Event Searches in Underground Astroparticle EXperiments","UNIVERSIDAD DE ZARAGOZA","€1,223,776","Gaseous detectors like TPCs are seldom used in Rare Event searches (like those looking for Dark Matter particles, Neutrinoless Double Beta Decay or other neutrino experiments) due mainly to the difficulty in reaching target masses large enough to be sensitive to the extremely low counting rates expected. However, very promising recent advances in TPC readouts based on micropatterns (e.g. the Micromegas concept) may overcome those limitations, making the application of TPCs to this kind of experi",{"id":644,"funder":7,"programme":8,"title":645,"piName":14,"institution":646,"country":80,"year":13,"amount":647,"abstract":648},"cordis-european-research-council-award-241231","Bosnian Bones, Spanish Ghosts: 'Transitional Justice' and the Legal Shaping of Memory after Two Modern Conflicts","GOLDSMITHS' COLLEGE","€1,420,000","The proposed research entails an ethnographic study of two contemporary cases of post-conflict reconciliation: one, the Bosnian case, where international intervention ended conflict in a stalemate and went on to instigate a decade-long process of transition; and the other, the Spanish case, where a nationally-contrived pact of silence introduced an overnight transition after Franco's death a pact now being broken nearly seventy years after the country's civil war concluded. Both societies witnes",{"id":650,"funder":7,"programme":8,"title":651,"piName":14,"institution":652,"country":12,"year":13,"amount":653,"abstract":654},"cordis-european-research-council-award-240113","Water anomalies in the stretched and supercooled regions","UNIVERSITE LYON 1 CLAUDE BERNARD","€1,335,400","Water is the most abundant liquid on Earth s surface. It is essential for life. Surprisingly, despite extensive studies, many of its properties remain to be explained. The aim of this project is to contribute to the understanding of water, by studying its anomalies in the metastable liquid state. A liquid should transform into vapour at its boiling point, or into a solid at its freezing point. However, it can be observed beyond these limits. It is then in a metastable state, separated from the s",{"id":656,"funder":7,"programme":8,"title":657,"piName":14,"institution":658,"country":12,"year":13,"amount":659,"abstract":660},"cordis-european-research-council-award-240132","Spiking neural models of auditory perception","ECOLE NORMALE SUPERIEURE","€1,244,640","In classical connectionism, the information is conveyed by the firing rate of neurons. Spiking neuron models offer an additional dimension to the rate: synchrony. Synchronous spike trains are more effective than uncorrelated ones in driving the responses of target neurons. Because neurons can encode their inputs in a sequence of precisely timed spikes, input similarity translates into synchronous spiking, which can be easily detected by afferent neurons. The dual properties of synchronization an",{"id":662,"funder":7,"programme":8,"title":663,"piName":14,"institution":664,"country":87,"year":13,"amount":665,"abstract":666},"cordis-european-research-council-award-241003","The demography of skills and beliefs in Europe with a focus on cohort change","INTERNATIONALES INSTITUT FUER ANGEWANDTE SYSTEMANALYSE","€981,415","The central research theme of this proposal is the study of social change (skills, productivity, attitudes and beliefs) in Europe along cohort lines and as a function of changing age composition. Using demographic methods, age-specific and cohort-specific changes shall be quantitatively disentangled. The impact of migration flows as well as fertility differentials combined with intergenerational transmissions will be taken into account. It is expected that viewed together, these analyses will re",{"id":668,"funder":7,"programme":8,"title":669,"piName":14,"institution":670,"country":26,"year":13,"amount":671,"abstract":672},"cordis-european-research-council-award-240819","New Issues in Macro Modeling","LUISS LIBERA UNIVERSITA INTERNAZIONALE DEGLI STUDI SOCIALI GUIDO CARLI","€648,000","This project aims at providing novel foundations for the aggregate supply and demand blocks of current macro models, which are extensively used for policy evaluation. On the aggregate-supply side, the first part of the proposal is motivated by recent extensive and consistent empirical evidence on the presence of downward nominal and real rigidities in developed economies. The objective is to investigate the theoretical and empirical implications of including these rigidities in current macro mod",{"id":674,"funder":7,"programme":8,"title":675,"piName":14,"institution":352,"country":20,"year":13,"amount":676,"abstract":677},"cordis-european-research-council-award-240842","An Iconology of the Textile in Art and Architecture","€686,000","The fabrication of textiles is one of the oldest cultural technologies. The objective of the proposed interdisciplinary research project is to investigate the historical meanings and functions of the textile medium in art and architecture from the Middle Ages to the present. The exploration of this specific art medium should result in a historical theory or iconology of the textile. The project focussed on the textile discourse engages in a new, complex, and challenging field of research situate",{"id":679,"funder":7,"programme":8,"title":680,"piName":14,"institution":681,"country":279,"year":13,"amount":682,"abstract":683},"cordis-european-research-council-award-240487","Predictive models and simulations in nano- and biomolecular mechanics: a multiscale approach","UNIVERSITAT POLITECNICA DE CATALUNYA","€1,462,198","The predictive ability of current simulations of interesting systems in nano- and biomolecular mechanics is questionable due to (1) uncertainties in material behavior of continuum models, (2) severe limitations of atomistic simulations in the computationally accessible length and time scales in relation with the scales of scientific and technological interest, and (3) the limited understanding gained from terabytes of data produced in supercomputing platforms. These difficulties seriously underm",{"id":685,"funder":7,"programme":8,"title":686,"piName":14,"institution":687,"country":261,"year":13,"amount":688,"abstract":689},"cordis-european-research-council-award-239685","Collagen scaffolds for bone regeneration: applied biomaterials, bioreactor and stem cell technology","ROYAL COLLEGE OF SURGEONS IN IRELAND","€1,999,530","Regenerative medicine aims to regenerate damaged tissues by developing functional cell, tissue, and organ substitutes to repair, replace or enhance biological function in damaged tissues. The focus of this research programme is to develop bone graft substitute biomaterials and laboratory-engineered bone tissue for implantation in damaged sites. At a simplistic level, biological tissues consist of cells, signalling mechanisms and extracellular matrix. Regenerative medicine\u002Ftissue engineering tech",{"id":691,"funder":7,"programme":8,"title":692,"piName":14,"institution":693,"country":44,"year":13,"amount":147,"abstract":694},"cordis-european-research-council-award-241118","By the Rivers of Babylon: New Perspectives on Second Temple Judaism from Cuneiform Texts","UNIVERSITEIT LEIDEN","This project has the potential to radically change current understanding of cultic and social transformation in the post-exilic temple community of Jerusalem (c. 6th-4th centuries BCE), an important formative phase of ancient Judaism. “BABYLON” draws on recent, ground-breaking advances in the study of cuneiform texts to illuminate the Babylonian environment of the Judean exile, the socio-historical context which gave rise to the transformative era in Second Temple Judaism. In particular, these n",{"id":696,"funder":7,"programme":8,"title":697,"piName":14,"institution":693,"country":44,"year":13,"amount":698,"abstract":699},"cordis-european-research-council-award-240394","Controlled fusion of liposomes and cells: a new pathway for direct drug delivery","€1,392,262","Inspired by the natural membrane fusion machinery, the aim of this research line is to design a synthetic analogue in order to: 1) Understand the process of the peptide-controlled fusion of two membranes at the atomic, molecular and mesoscopic level. 2) Developing a new generic method for the controlled delivery of any (bio)molecule directly into the cytoplasm of a cell thereby omitting endocytotic pathways. This new paradigm opens many new applications in the fields of functional proteomics, ge",{"id":701,"funder":7,"programme":8,"title":702,"piName":14,"institution":693,"country":44,"year":13,"amount":191,"abstract":703},"cordis-european-research-council-award-209801","The formation of Islam: The view from below","My project is to write a history of the formation of Islam using the vastly important but largely neglected papyri from Egypt. Until the introduction of paper in the 10th C., papyrus was the Mediterranean world’s primary writing material. Thousands of papyrus documents survive, preserving a minutely detailed transcription of daily life, as well as the only contemporary records of Islam’s rise and first wave of conquests. As an historian and papyrologist, my career has been dedicated to developin",{"id":705,"funder":7,"programme":8,"title":706,"piName":14,"institution":707,"country":50,"year":13,"amount":708,"abstract":709},"cordis-european-research-council-award-242710","Hyperpolarized Biosensors in Molecular Imaging","FORSCHUNGSVERBUND BERLIN EV","€1,848,600","Xenon biosensors have an outstanding potential to increase the significance of magnetic resonance imaging (MRI) in molecular imaging and to combine the advantages of MRI with the high sensitivity of hyperpolarized Xe-129 and the specificity of a functionalized contrast agent. Based on new detection schemes (Hyper-CEST method) in Xe MRI, this novel concept in molecular diagnostics will be made available for biomedical applications. The advancement focuses on high-sensitivity in vitro diagnostics ",{"id":711,"funder":7,"programme":8,"title":712,"piName":14,"institution":713,"country":50,"year":13,"amount":353,"abstract":714},"cordis-european-research-council-award-204757","The geometry of topological quantum field theories","ALBERT-LUDWIGS-UNIVERSITAET FREIBURG","The predictive power of quantum field theory (QFT) is a perpetual driving force in geometry. Examples include the invention of Frobenius manifolds, mixed twistor structures, primitive forms, and harmonic bundles, up to the discovery of the McKay correspondence, mirror symmetry, and Gromov-Witten invariants. Still seemingly disparate, in fact these all are related to topological (T) QFT and thereby to the work by Cecotti, Vafa et al of more than 20 years ago.  The broad aim of the proposed resear",{"id":716,"funder":7,"programme":8,"title":717,"piName":14,"institution":718,"country":50,"year":13,"amount":719,"abstract":720},"cordis-european-research-council-award-240544","Construction of a Molecular Crane Based on the Flavoprotein Dodecin","UNIVERSITAET SIEGEN","€1,100,000","The flavoprotein dodecin from the halophilic organism Halobacterium salinarum binds not only native but also artificial flavins with high affinities in their oxidized state. Reduction of the flavins induces the dissociation of the holocomplex into apododecin and free flavin. Based on these unique binding characteristics, a molecular crane shall be developed that is able to pick up and to release molecular objects through a switch of the electric potential. For this purpose, a single flavin has t",{"id":722,"funder":7,"programme":8,"title":723,"piName":14,"institution":724,"country":725,"year":13,"amount":726,"abstract":727},"cordis-european-research-council-award-207542","Time-resolved Ring-Cavity-Enhanced Polarization Spectroscopy: Breakthroughs in measurements of a) Atomic Parity Violation, b) Protein conformation and biosensing and c) surface and thin film dynamics","IDRYMA TECHNOLOGIAS KAI EREVNAS","EL","€909,999","Polarimetry is a crucial tool in both fundamental and applied physics, ranging from the measurement of parity nonconservation (PNC) in atoms, to the determination of biomolecule structure, and the probing of interfaces. These measurements tend to be extremely challenging as the change of the polarization of light is usually extremely small; typical differences in polarization states are of the order of 10^-5 to 10^-8. Current experimental techniques often require acquisition times of the order o",{"id":729,"funder":7,"programme":8,"title":730,"piName":14,"institution":731,"country":80,"year":13,"amount":732,"abstract":733},"cordis-european-research-council-award-207282","Study of Neutrino Oscillations at T2K","QUEEN MARY UNIVERSITY OF LONDON","€950,000","Neutrinos are among the most intriguing, least understood and probably most abundant particles in the Universe. The most exciting discovery of the last decade is that different neutrino types do change their identity as they propagate, suggesting that they are not strictly massless as required by the Standard Model of Particle Physics. Improving our understanding of neutrinos, which is one of the main priorities of the European strategy for particle physics, has the potential to unravel some of ",{"id":735,"funder":7,"programme":8,"title":736,"piName":14,"institution":737,"country":50,"year":13,"amount":14,"abstract":738},"cordis-european-research-council-award-243045","MECHANISMS UNDERLYING CELL FATE DECISION BETWEEN PANCREAS AND LIVER","MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)","Diabetes is a degenerative disease affecting millions of persons worldwide. A cure for diabetes depends on replacing the insulin-producing ²-cells in the pancreas that are destroyed by the disease. An attractive strategy to attain this goal is to convert liver adult cells of the same patient into pancreatic ²-cells. The liver and pancreas share many aspects of their early development and are specified in adjacent regions of the endoderm, possibly from a common bipotent progenitor cell. Therefore",{"id":740,"funder":7,"programme":8,"title":741,"piName":14,"institution":742,"country":80,"year":13,"amount":743,"abstract":744},"cordis-european-research-council-award-241125","The medicine of the mind and natural philosophy in early modern England: A new interpretation of Francis Bacon","UNIVERSITY OF LONDON","€899,886","The aim of the project is to provide a groundbreaking new interpretation of Francis Bacon's natural philosophy. The original aspect of this project will consist in a new contextualisation of Bacon's philosophy. We argue that his work can be seen as one of the most characteristic products of what we have decided to call, for reasons of heuristic and exegetical convenience, the medicine of the mind. This project is interdisciplinary in both the method we are going to apply and the object we are go",{"id":746,"funder":7,"programme":8,"title":747,"piName":14,"institution":748,"country":12,"year":13,"amount":749,"abstract":750},"cordis-european-research-council-award-242703","RNAi-mediated viral immunity in insects","INSTITUT PASTEUR","€1,900,000","RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that is induced by double-stranded RNA (dsRNA). One of the functions of this pathway is the defense against parasitic nucleic acids: transposons and viruses. Previous results demonstrated that viral infections in Drosophila melanogaster are fought by an antiviral RNAi response and that components of the endocytic pathway are required for dsRNA entry to initiate the RNAi response. Recently we have shown that infect",{"id":752,"funder":7,"programme":8,"title":753,"piName":14,"institution":748,"country":12,"year":13,"amount":754,"abstract":755},"cordis-european-research-council-award-242719","RNA virus population diversity, virulence, attenuation and vaccine development","€1,870,000","RNA viruses have the highest mutation frequencies in nature, which are in large part attributed to the low fidelity of their viral RNA-dependent RNA polymerases (RdRp). Explosive replication kinetics coupled with high mutation rates quickly generate highly diverse populations that have been observed for all RNA viruses. Recently, we have developed a model system to study the roles that RNA virus mutation rates and population heterogeneity play in virus fitness, virulence and pathogenesis in vivo",{"id":757,"funder":7,"programme":8,"title":758,"piName":14,"institution":759,"country":80,"year":13,"amount":760,"abstract":761},"cordis-european-research-council-award-241069","Global Governance and Gender Disparities. Explaining Developments in Key Labor related Human Rights Indicators","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","€1,090,409","How successful are current initiatives at furthering a fairer globalization? Employing women’s equitable integration into the labor market as a paradigmatic case, this proposal suggests ways to examine the impact of global governance structures on key labor market and other indicators. Research in this project so far has shown that for an adequate assessment of women’s equity it is not sufficient to merely look at their labor market position but an examination of indicators such as political par",{"id":763,"funder":7,"programme":8,"title":764,"piName":14,"institution":765,"country":57,"year":13,"amount":766,"abstract":767},"cordis-european-research-council-award-239986","Multiphoton Ionization Nano-Therapy","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","€1,782,600","The application of nanotechnology for addressing key problems in clinical diagnosis and therapy holds great promise in medicine and in cancer in particular. Recent works have shown significant progress in nanoparticle-mediated drug delivery and therapy. In these applications, however, the small dimensions of the nanoparticles have been used primarily for efficient delivery and specificity, while the effects mediated by the nanoparticles occur away from the particle itself, affecting the entire c",{"id":769,"funder":7,"programme":8,"title":770,"piName":14,"institution":658,"country":12,"year":13,"amount":353,"abstract":771},"cordis-european-research-council-award-208111","Modeling cytoplasmic trafficking and molecular delivery in cellular microdomains","Cytoplasmic motion is a key determinant of organelle transport, protein-protein interactions, RNA transport and drug delivery, to name but a few cellular phenomena. Nucleic acid trafficking is important in antisense and gene therapy based on viral and synthetic vectors. This proposal is dedicated to the theoretical study of intracellular transport of proteins, organelles and DNA particles. We propose to construct a mathematical model to quantify and predict the spatiotemporal dynamics of complex",{"id":773,"funder":7,"programme":8,"title":774,"piName":14,"institution":775,"country":279,"year":13,"amount":776,"abstract":777},"cordis-european-research-council-award-240989","Globalization, Optimal Policies and Growth","Centre de Recerca en Economia Internacional (CREI)","€450,000","This project studies the challenges that policy makers face in a world where globalization is proceeding at high speed and knowledge creation is the key to prosperity. It consists of two main parts: one focuses on optimal growth policies, the other on policy externalities induced by market integration. The first part builds on the premise that fostering innovation requires appropriate regulations on product market competition and on Intellectual Property Rights. The following questions will be a",{"id":779,"funder":7,"programme":8,"title":780,"piName":14,"institution":759,"country":80,"year":13,"amount":14,"abstract":781},"cordis-european-research-council-award-240852","Research on Economic Fluctuations and Globalization","The first strand of the proposal seeks to study housing market fluctuations. Housing markets play a prominent role in the economy and in the conduct of monetary policy and yet standard DSGE models often ignore them. In a first project, we will study both empirically and theoretically seasonal fluctuations in housing markets. We view this as an important first step to shed light on the models needed to describe housing markets. A second project will build on these modelling implications to develo",{"id":783,"funder":7,"programme":8,"title":784,"piName":14,"institution":785,"country":80,"year":13,"amount":786,"abstract":787},"cordis-european-research-council-award-200583","Encoded Cellular Synthesis of Unnatural Biopolymers","MEDICAL RESEARCH COUNCIL","€1,782,918","We are building a parallel and independent (orthogonal) translational machinery for the encoded biosynthesis of unnatural polymers in living cells. The orthogonal translation system has many potential applications beyond those possible with the natural translation system: I propose to use it: 1) To expand the chemical scope of monomers that can be polymerized by the ribosome in living cells, allowing the incorporation of monomers with unnatural backbones into proteins; 2) To increase the efficie",{"id":789,"funder":7,"programme":8,"title":790,"piName":14,"institution":791,"country":279,"year":13,"amount":14,"abstract":792},"cordis-european-research-council-award-240222","Precedents for Algal Adaptation to Atmospheric CO2: New indicators for eukaryotic algal response to the last 60 million years of CO2 variation","UNIVERSIDAD DE OVIEDO","Evolution of marine algae over the last 60 million years has resulted in a fundamental change in the efficiency of biological carbon pump and shift from communities dominated by calcifying algae (like coccolithophorids) to siliceous diatoms and major size class changes among these groups. The inferred shift in atmospheric CO2 over this time period has been suggested as an important selective pressure on some of these responses, including diatom adaptation to lower atmospheric CO2 concentrations ",{"id":794,"funder":7,"programme":8,"title":795,"piName":14,"institution":796,"country":80,"year":13,"amount":797,"abstract":798},"cordis-european-research-council-award-241132","The Foundation of Organization Design","LONDON BUSINESS SCHOOL","€378,162","Organization design refers to choices about the formal structure of organizations. While the study of organization design is not new, it is not current either. This proposal describes a series of theory development projects I aim to undertake over the next three years towards strengthening the foundations of organization design as an area of academic enquiry. The projects focus on a) interactions between incentive and coordination mechanisms b) an improved representation and framework for studyi",{"id":800,"funder":7,"programme":8,"title":801,"piName":14,"institution":802,"country":26,"year":13,"amount":803,"abstract":804},"cordis-european-research-council-award-239640","PHOtonic-based full DIgital Radar","CONSORZIO NAZIONALE INTERUNIVERSITARIO PER LE TELECOMUNICAZIONI","€1,600,000","PHODIR project aims to study, design and realize a full digital transceiver radar demonstrator based on photonic technology both for signal generation and for RF received signal processing. Hybrid technologies merging second generation optical systems and conventional radar architecture could be the answer to issues deriving from electronic devices poor performances such high SFDR (Spurious Free Dynamic Range) and high phase noise level that are nowadays impeding the construction of a fully digi",{"id":806,"funder":7,"programme":8,"title":807,"piName":14,"institution":808,"country":50,"year":13,"amount":809,"abstract":810},"cordis-european-research-council-award-240720","Cultural Heritage of Christian Ethiopia: Salvation, Preservation and Research","UNIVERSITAET HAMBURG","€1,746,080","Ethiopia is one of the countries with the most ancient Christian history, and the only country in Africa where Christianity became official religion as early as in the 4th century A.D. It is also the only country in the region where the history has been documented in written sources: manuscripts in possession of ca. 600 monasteries and 20,000 churches, some of which date back to early Middle Ages, have been estimated to number up to ca. 200,000. Only a minor part of these archives have so far re",{"id":812,"funder":7,"programme":8,"title":813,"piName":14,"institution":814,"country":12,"year":13,"amount":815,"abstract":816},"cordis-european-research-council-award-243103","Spatio-temporal regulation of antigen presentation and cell migration","INSTITUT CURIE","€1,980,000","The immune system is constituted by different cell populations, which circulate between lymphoid organs and peripheral tissues as a result of their high migratory capacity. We have shown that Antigen (Ag) processing and migration of Ag Presenting Cells (APCs) are co-regulated by a protein complex that contains the MHC class II-associated Invariant Chain (Ii) and the actin-based motor protein Myosin II. While the association between Ii and Myosin II promotes Ag processing for presentation onto MH",{"id":818,"funder":7,"programme":8,"title":819,"piName":14,"institution":820,"country":725,"year":13,"amount":821,"abstract":822},"cordis-european-research-council-award-243322","Immune mechanisms of osteopontin-mediated protection in allergic airway disease","IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON","€1,511,200","In allergic asthma, an important health problem, disease is driven by allergen-specific Th2 immune responses. Differentiation of Th2 cells depends on their early interactions with antigen presenting cells, such as dendritic cells (DCs), and cytokines are crucial for this process. Osteopontin (Opn) was originally identified as an important cytokine for Th1 immunity and autoimmunity. Our group recently demonstrated that Opn is highly expressed in the lungs of asthmatic patients and of mice with Th",{"id":824,"funder":7,"programme":8,"title":825,"piName":14,"institution":826,"country":827,"year":13,"amount":828,"abstract":829},"cordis-european-research-council-award-243153","Understanding the molecular blueprint and functional complexity of the endocannabinoid metabolome in the brain","HUN REN KISERLETI ORVOSTUDOMANYI  KUTATOINTEZET","HU","€1,638,000","We and others have recently delineated the molecular architecture of a new feedback pathway in brain synapses, which operates as a synaptic circuit breaker. This pathway is supposed to use a group of lipid messengers as retrograde synaptic signals, the so-called endocannabinoids. Although heterogeneous in their chemical structures, these molecules along with the psychoactive compound in cannabis are thought to target the same effector in the brain, the CB1 receptor. However, the molecular catalo",{"id":831,"funder":7,"programme":8,"title":832,"piName":14,"institution":833,"country":26,"year":13,"amount":834,"abstract":835},"cordis-european-research-council-award-242928","Regulatory mechanisms coordinating replication integrity and intra-S repair","IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS","€1,841,600","The RecQ family of helicases, including BLM in human and its Saccharomyces cerevisiae homolog Sgs1, have important roles in maintaining genome stability. Sgs1 plays a specific role in response to intra-S DNA damage by resolving the pseudo double HJs resulting from replication-related sister chromatid junctions (SCJs). These catenated DNA structures are thought to represent template switch (TS) intermediates. Although the molecular mechanism is largely unknown, TS is thought to represent a major ",{"id":837,"funder":7,"programme":8,"title":838,"piName":14,"institution":765,"country":57,"year":13,"amount":353,"abstract":839},"cordis-european-research-council-award-203134","Asymptotic Geometric Analysis and Learning Theory","In a typical learning problem one tries to approximate an unknown function by a function from a given class using random data, sampled according to an unknown measure. In this project we will be interested in parameters that govern the complexity of a learning problem. It turns out that this complexity is determined by the geometry of certain sets in high dimension that are connected to the given class (random coordinate projections of the class). Thus, one has to understand the structure of the",{"id":841,"funder":7,"programme":8,"title":842,"piName":14,"institution":843,"country":50,"year":13,"amount":844,"abstract":845},"cordis-european-research-council-award-243046","Cytosolic recognition of foreign nucleic acids: Molecular and functional characterization of AIM2, a central player in DNA-triggered inflammasome activation","UNIVERSITATSKLINIKUM BONN","€1,727,920","Host cytokines, chemokines and type I IFNs are critical effectors of the innate immune response to viral and bacterial pathogens. Several classes of germ-line encoded pattern recognition receptors have been identified, which sense non-self nucleic acids and trigger these responses. Recently NLRP-3, a member of the NOD-like receptor (NLR) family, has been shown to sense endogenous danger signals, environmental insults and the DNA viruses adenovirus and HSV. Activation of NLRP-3 induces the format",{"id":847,"funder":7,"programme":8,"title":848,"piName":14,"institution":849,"country":26,"year":13,"amount":850,"abstract":851},"cordis-european-research-council-award-241114","Institutions and Globalization","UNIVERSITA COMMERCIALE LUIGI BOCCONI","€1,002,000","Economists have recently shown that developed economies rely on proper institutions for securing property rights, resolving disputes, etc. Scholars have studied the consequences of alternative legal and political institutions, but much remains to be done. One important and unexplored territory concerns the analysis of how national institutions interact in the international arena. This proposal seeks to study this problem from two perspectives. First, how does the quality of a country s national ",{"id":853,"funder":7,"programme":8,"title":854,"piName":14,"institution":855,"country":856,"year":13,"amount":857,"abstract":858},"cordis-european-research-council-award-243393","Neural mechanisms of action learning and action selection: from intent to habit","FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD","PT","€1,526,304","In every day life, we constantly have to select the appropriate actions to obtain specific outcomes. Actions can be selected based on their consequences, for example when we press an elevator button to get to the particular floor where we live. This goal-directed behaviour is crucial to face the ever-changing environment but demands an effortful control and monitoring of the response; one way to balance the need for flexibility and efficiency is through automatization of recurring decision proce",{"id":860,"funder":7,"programme":8,"title":861,"piName":14,"institution":765,"country":57,"year":13,"amount":862,"abstract":863},"cordis-european-research-council-award-240258","Proofs and Computation","€1,743,676","The project described in this proposal studies formal proofs and their interaction with computation. The study of propositional proofs is connected to a spectrum of problems in our field, starting with the meta-mathematical quest to explain our failure to understand computation and make progress on the basic questions haunting our field (such as P vs. NP), and ending with the industry-driven quest for better algorithms for solving instances of the satisfiability problem. In a seemingly different",{"id":865,"funder":7,"programme":8,"title":866,"piName":14,"institution":867,"country":856,"year":13,"amount":868,"abstract":869},"cordis-european-research-council-award-239953","EXtra-solar planets and stellar astrophysics: towards the detection of Other Earths","CENTRO DE INVESTIGACAO EM ASTRONOMIA E ASTROFISICA DA UNIVERSIDADE DOPORTO ASSOCIACAO","€928,090","The detection of more than 300 extrasolar planets orbiting other solar-like stars opened the window to a new field of astrophysics. Many projects to search for Earth-like planets are currently under way, using a huge battery of telescopes and instruments. New instrumentation is also being developed towards this goal for use in both ground- and space-based based facilities. Since planets come as an output of the star formation process, the study of the stars hosting planets is of great importance",{"id":871,"funder":7,"programme":8,"title":872,"piName":14,"institution":646,"country":80,"year":13,"amount":873,"abstract":874},"cordis-european-research-council-award-241242","Human Embodied MultiSensory Development: An investigation of the construction of embodied multisensory experience in human infancy and early childhood","€1,227,752","We perceive our body and peripersonal environment through multiple sensory modalities. The distance receptors (e.g., vision and audition), provide information about stimuli in both personal and extrapersonal space. The direct receptors (e.g., touch and proprioception) provide information about the body and external stimuli impinging on the body. Having multiple modalities bestows advantages by providing complementary and independent sources of information about the environment and consequently m",{"id":876,"funder":7,"programme":8,"title":877,"piName":14,"institution":372,"country":50,"year":13,"amount":878,"abstract":879},"cordis-european-research-council-award-209214","Understanding Preferences: Measurement, Prevalence, Determinants and Consequences","€1,340,000","This project analyzes the distribution, origin, determinants and consequences of human preferences. Preferences are key building blocks of any economic model and fundamentally determine human behavior both at an individual and a country wide level. Four particularly important types of preferences, which will be studied in this research project, are risk preferences, time preferences, social preferences and preferences for work and leisure. Despite their fundamental importance, empirical knowledg",{"id":881,"funder":7,"programme":8,"title":882,"piName":14,"institution":883,"country":158,"year":13,"amount":353,"abstract":884},"cordis-european-research-council-award-203767","Subjectivity and Selfhood in the Arabic and Latin Traditions","JYVASKYLAN YLIOPISTO","The overall aim of the SSALT project is to throw light on the incubation of modern notions of the self and moral agency in the thought of the ancient world, their adoption and adaptation in the European and Arabic middle ages, and finally their transformation in the early modern period. This aim is approached through the twin paths of Arabic and Latin thought, both of which were in equal measure heir to the legacies of Greek rationalism and Hebrew monotheism. 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