[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-starting-grant-2012":3,"awarded-stats-erc-starting-grant":1048},{"awarded":4,"total":1047},[5,16,23,29,35,42,48,53,60,67,71,77,82,89,94,99,106,113,119,124,131,136,141,146,151,155,160,166,171,176,181,186,191,196,202,207,212,218,222,227,234,238,244,248,253,257,262,267,271,276,281,286,290,296,300,304,308,313,318,324,328,332,337,342,346,351,356,361,367,371,376,382,387,391,396,401,405,410,415,420,424,429,435,441,447,453,458,463,470,475,480,485,489,494,498,503,510,515,521,527,532,537,544,549,554,558,563,569,574,580,587,592,598,603,608,613,617,622,627,633,637,641,646,651,656,662,667,672,678,684,689,694,699,705,711,717,721,726,731,736,740,744,748,753,759,764,770,775,781,787,792,798,803,809,816,820,824,829,834,840,845,850,855,861,866,871,876,880,884,889,894,899,903,907,911,917,922,927,932,937,942,947,952,958,963,968,973,978,984,990,995,1000,1006,1010,1015,1021,1026,1031,1037,1042],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-european-research-council-award-erc-2009-stg-240317","European Research Council","ERC Starting Grant","Combinatiorial algorithms for wireless information flow","Javad B. Ebrahimi","École Polytechnique Fédérale de Lausanne","CH",2012,null,"A long-standing open question in information theory is to characterize the unicast capacity of a wireless relay network. The difficulty arises due to the complex signal interactions induced in the network, since the wireless channel inherently broadcasts the signals and there is interference among transmissions. Recently, Avestimehr et al. [2007b] proposed a linear deterministic model that takes into account the shared nature of wireless channels, focusing on the signal interactions rather than ",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":21,"year":13,"amount":14,"abstract":22},"openalex-european-research-council-award-erc-2007-stg-nr-203872","Scanning optical microscopy modeling in nanoplasmonics","Alexandre Teulle","Centre d’Élaboration de Matériaux et d’Études Structurales","FR","One of the main purposes of nanoplasmonics is the miniaturization of optical and electro-optical components that could be integrable in coplanar geometry. In this context, we propose a numerical model of a polarized scanning optical microscope able to faithfully reproduce both photon luminescence and temperature distribution images associated with complex plasmonic structures. The images are computed, pixel by pixel, through a complete self-consistent scheme based on the Green dyadic functions (",{"id":24,"funder":7,"programme":8,"title":25,"piName":26,"institution":27,"country":28,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2009-stg-242932","Dysregulated dopamine storage increases the vulnerability to α-synuclein in nigral neurons","Ayşe Ulusoy","Lund University","SE",{"id":30,"funder":7,"programme":8,"title":31,"piName":32,"institution":33,"country":34,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2010-stg-259218-nucleareft","Calculation of doublet capture rate for muon capture in deuterium within chiral effective field theory","J. Adam","Czech Academy of Sciences, Nuclear Physics Institute","CZ",{"id":36,"funder":7,"programme":8,"title":37,"piName":14,"institution":38,"country":39,"year":13,"amount":40,"abstract":41},"cordis-european-research-council-award-282250","E3 - Extreme Event Ecology","TECHNISCHE UNIVERSITAET MUENCHEN","DE","€1,487,000","With anthropogenic warming, extreme events have already increased in magnitude and frequency and are likely to continue to do so in the near future. These extreme events play decisive roles in climate change impacts. Natural and managed systems, such as agriculture and forestry, are more strongly affected by extremes than by a change in average conditions. Classical parameters considered have included temperature, precipitation and wind speed, but here we will concentrate on multi-factorial comp",{"id":43,"funder":7,"programme":8,"title":44,"piName":14,"institution":45,"country":12,"year":13,"amount":46,"abstract":47},"cordis-european-research-council-award-279779","Accretion and Differentiation of Terrestrial Planets","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","€1,994,545","This proposal aims to constrain the late accretion history of the Earth and the differentiation of the earliest silicate reservoirs in planets. Highly siderophile elements (HSE) constrain the late accretion of material onto the Earth; a process that potentially delivered water to Earth. During core formation, HSE strongly partition into metal. Once core formation ceases, newly accreted HSE-rich material will significantly contribute to the HSE budget of the Earth’s mantle. The HSE are more abund",{"id":49,"funder":7,"programme":8,"title":50,"piName":14,"institution":45,"country":12,"year":13,"amount":51,"abstract":52},"cordis-european-research-council-award-306793","Catalytic asymmetric synthesis of amines and amides","€1,500,000","Amines and their acylated derivatives – amides – are among the most common chemical functional groups found in modern pharmaceuticals. Despite this there are few methods for their efficient, environmentally sustainable production in enantiomerically pure form. This proposal seeks to provide new catalytic chemical methods including 1) the catalytic, enantioselective synthesis of peptides and 2) catalytic methods for the preparation of enantiopure nitrogen-containing heterocycles. The proposed wor",{"id":54,"funder":7,"programme":8,"title":55,"piName":14,"institution":56,"country":57,"year":13,"amount":58,"abstract":59},"cordis-european-research-council-award-306292","Controlling Non-Equilibrium in Steels","TECHNISCHE UNIVERSITEIT DELFT","NL","€1,482,011","Stronger and more ductile steels are increasingly demanded for advanced applications. Latest investigations show that nanostructured steels formed by non-equilibrium phases increasing strength, such as martensite and bainite, and enhancing strain hardening, such as austenite, fulfil these demands with outstanding performance.In the last few years, I have observed that non-equilibrium phases strongly affect each other’s formation and stability, with effects on the kinetics of the microstructure d",{"id":61,"funder":7,"programme":8,"title":62,"piName":14,"institution":63,"country":64,"year":13,"amount":65,"abstract":66},"cordis-european-research-council-award-307245","Interferometry beyond the Standard Quantum Limit using a Velocity Sensitive Sagnac Interferometer","UNIVERSITY OF GLASGOW","UK","€1,399,260","From the very first Michelson Interferometer invented over 100 years ago to today’s kilometre-scale gravitational wave detectors the sensitivity of interferometric length measurements has been improved by about 10 orders of magnitude and is now limited by the so-called Standard Quantum Limit (SQL), a manifestation of Heisenberg’s Uncertainty Principle. The SQL is comprised of the inevitable combination of sensing noise (photon shot noise) and back action noise (photon radiation pressure noise) w",{"id":68,"funder":7,"programme":8,"title":69,"piName":14,"institution":56,"country":57,"year":13,"amount":51,"abstract":70},"cordis-european-research-council-award-309509","Unveiling the Molecular Basis of RNA Interference with Single Molecule Fluorescence","Recent groundbreaking discoveries have changed our view on RNA from that of a passive information carrier to an important regulatory element. MicroRNA is a small regulatory RNA that controls nearly all mRNAs in eukaryotic cells. Since this regulation process (termed RNA interference\u002FRNAi) occurs in a sequence-specific manner, we can manipulate gene expression using custom-designed small RNAs. This remarkable discovery introduced the possibility of RNA-based gene therapy and triggered intensive r",{"id":72,"funder":7,"programme":8,"title":73,"piName":14,"institution":74,"country":57,"year":13,"amount":75,"abstract":76},"cordis-european-research-council-award-306810","Subduction Initiation reconstructed from Neotethyan Kinematics (SINK): An iterative geological and numerical study of the driving forces behind plate tectonics","UNIVERSITEIT UTRECHT","€1,499,880","The concept of Plate Tectonics, as fundamentally unifying to Earth Sciences as Darwin’s Evolution Theory is to Life Sciences, mathematically describes the complex evolution of Earth’s outer shell in terms of lithosphere plates and their interactions. There is no widely accepted dynamic mechanism, however, that explains why plate tectonics developed and continues. Subduction of oceanic lithosphere into the mantle, compensated by spreading of new oceanic lithosphere elsewhere is a key element of p",{"id":78,"funder":7,"programme":8,"title":79,"piName":14,"institution":38,"country":39,"year":13,"amount":80,"abstract":81},"cordis-european-research-council-award-306274","High-Dimensional Sparse Optimal Control","€1,123,000","We are addressing the analysis and numerical methods for the tractable simulation and the optimal control of dynamical systems which are modeling the behavior of a large number N of complex interacting agents described by a large amount of parameters (high-dimension). We are facing fundamental challenges:- Random projections and recovery for high-dimensional dynamical systems: we shall explore how concepts of data compression via Johnson-Lindenstrauss random embeddings onto lower-dimensional spa",{"id":83,"funder":7,"programme":8,"title":84,"piName":14,"institution":85,"country":86,"year":13,"amount":87,"abstract":88},"cordis-european-research-council-award-281633","The Evolution of the Chlamydiae - an Experimental Approach","UNIVERSITAT WIEN","AT","€1,499,621","Chlamydiae are a unique group of obligate intracellular bacteria that comprises symbionts of protozoa as well as important pathogens of humans and a wide range of animals. The intracellular life style and the obligate association with a eukaryotic host was established early in chlamydial evolution and possibly also contributed to the origin of the primary phototrophic eukaryote. While much has been learned during the past decade with respect to chlamydial diversity, their evolutionary history, p",{"id":90,"funder":7,"programme":8,"title":91,"piName":14,"institution":45,"country":12,"year":13,"amount":92,"abstract":93},"cordis-european-research-council-award-307270","Measuring attosecond electron dynamics in molecules","€1,999,992","The goal of the present proposal is to realize measurements of electronic dynamics in polyatomicmolecules with attosecond temporal resolution (1 as = 10^-18s). We propose to study electronicrearrangements following photoexcitation, charge migration in a molecular chain induced byionization and non-adiabatic multi-electron dynamics in an intense laser field. The grand questionaddressed by this research is the characterization of electron correlations which control the shape, properties and functi",{"id":95,"funder":7,"programme":8,"title":96,"piName":14,"institution":97,"country":21,"year":13,"amount":51,"abstract":98},"cordis-european-research-council-award-307184","Search for a fourth neutrino with a PBq anti-neutrino source","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","Several observed anomalies in neutrino oscillation data can be explained by a hypothetical fourth neutrino separated from the three standard neutrinos by a squared mass difference of a few eV2. This hypothesis can be tested with a PBq (ten kilocurie scale) 144Ce antineutrino beta-source deployed at the center of a large low background liquid scintillator detector, such like Borexino, KamLAND, and SNO+. In particular, the compact size of such a source could yield an energy-dependent oscillating p",{"id":100,"funder":7,"programme":8,"title":101,"piName":14,"institution":102,"country":103,"year":13,"amount":104,"abstract":105},"cordis-european-research-council-award-310649","Frontiers of Oxidative Protein Folding and Assembly: Catalysis of Disulfide Formation Downstream of the Endoplasmic Reticulum","WEIZMANN INSTITUTE OF SCIENCE","IL","€1,498,083","Quiescin sulfhydryl oxidase (QSOX), which catalyzes disulfide cross-linking in proteins, is up-regulated in many tumor types. QSOX is the only disulfide catalyst to undergo regulated secretion from cells, but the biological role of the enzyme, its substrates, and its mechanistic link to cancer are obscure. In addition to determining the first X-ray crystal structures of QSOXs, we recently discovered that QSOX is required for incorporation of laminins into basement membrane extracellular matrix (",{"id":107,"funder":7,"programme":8,"title":108,"piName":14,"institution":109,"country":110,"year":13,"amount":111,"abstract":112},"cordis-european-research-council-award-307523","advanced Light mIcroscopy for Green cHemisTry","KATHOLIEKE UNIVERSITEIT LEUVEN","BE","€1,999,485","Optimization of catalytic materials and hence of chemical processes heavily relies on gaining detailed insight into the complex dynamics underlying the outcome of a catalytic process and using this information in the rational design of improved catalysts. So far, spectroscopic approaches have already contributed importantly",{"id":114,"funder":7,"programme":8,"title":115,"piName":14,"institution":116,"country":39,"year":13,"amount":117,"abstract":118},"cordis-european-research-council-award-280840","Nuclear foundations of cellular potency","HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH","€1,496,000","A fundamental question in biology is to understand the mechanisms underlying cell plasticity. Such plasticity or potency is essential to form multiple cell types upon differentiation. In mammals, upon fertilization and fusion of the gametes –two highly differentiated cells- intense chromatin remodeling and epigenetic reprogramming, the reversion into an undifferentiated state, are essential to restore full developmental potency (totipotency). Subsequent development and differentiation are accomp",{"id":120,"funder":7,"programme":8,"title":121,"piName":14,"institution":45,"country":12,"year":13,"amount":122,"abstract":123},"cordis-european-research-council-award-310005","Phase contrast X-ray imaging for medicine","€1,499,300","The goal of this grant is to introduce grating-based phase contrast enhanced X-ray imaging as a novel diagnostic tool in human medicine. We will first gain fundamental knowledge to master high-energy grating-based phase contrast imaging and develop novel radiological equipment at the demonstrator\u002Fprototype level to perform phase contrast enhanced investigation in human patients in-vivo. In a second phase, we will investigate in depth how our novel method applies to a few pivotal medical fields l",{"id":125,"funder":7,"programme":8,"title":126,"piName":14,"institution":127,"country":128,"year":13,"amount":129,"abstract":130},"cordis-european-research-council-award-307624","Time-Domain RF and Analog Signal Processing","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","IE","€1,497,000","One of the most important developments in the communication microelectronics in the last decade was the invention and popularization of “Digital RF”. It transforms the radio frequency (RF) analog functionality of a wireless transceiver into digitally-intensive implementations that operate in time-domain. They are best realized in mainstream nanometer-scale CMOS technologies and easily integrated with digital processors. As a result, RF transceivers based on this new approach now enjoy significan",{"id":132,"funder":7,"programme":8,"title":133,"piName":14,"institution":102,"country":103,"year":13,"amount":134,"abstract":135},"cordis-european-research-council-award-310320","Uncovering metabolic cycles in mammals and dissecting their interplay with circadian clocks","€1,499,980","The physiology and behavior of mammals are subject to daily oscillations that are driven by an endogenous circadian clock. The mammalian circadian timing system is composed of a central pacemaker in the brain that is entrained by daily light-dark cycles and in turn synchronizes subsidiary oscillators in virtually all cells of the body. The core clock molecular circuitry is based on interlocked negative transcription-translation feedback loops that generate daily oscillations of gene expression i",{"id":137,"funder":7,"programme":8,"title":138,"piName":14,"institution":102,"country":103,"year":13,"amount":139,"abstract":140},"cordis-european-research-council-award-306706","Ergodic Group Theory","€1,150,000","The aim of the proposed research is gaining a better understanding of locally compact groups and their lattices. Our tools are mainly ergodic theoretical.We propose a variety of novel ideas that open new horizons for research.The first meta idea is the adoption of tools from the semi-simple theory in order to apply them for general locally compact groups. In particular, we suggest a construction of a Weyl group and an abstract definition of rank for every locally compact group. We are able to co",{"id":142,"funder":7,"programme":8,"title":143,"piName":14,"institution":102,"country":103,"year":13,"amount":144,"abstract":145},"cordis-european-research-council-award-281171","Deciphering neural codes of valence-based emotional memories","€1,671,620","Pioneering studies from the last decades have shown that we can use animal models to study the neural correlates of learning and emotional memories. These studies have identified a network of brain regions that co-orchestrate the dynamic processes that occur during acquisition, retrieval and update of memories with valence. In primates, these areas and their connectivity have evolved to allow a complex interaction between cognitive abilities and emotions. Although we know that emotional memories",{"id":147,"funder":7,"programme":8,"title":148,"piName":14,"institution":149,"country":57,"year":13,"amount":51,"abstract":150},"cordis-european-research-council-award-307679","Stomatocyte Nanomotors: Programmed Supramolecular Architectures for Autonomous Movement","STICHTING RADBOUD UNIVERSITEIT","The main goal of this ERC proposal is to harness a completely new approach to constructing biocompatible nanomotors, using supramolecular assembly of amphiphilic block-copolymers for loading the engine and catalysis as the driving force for autonomous movement. Polymersomes assembled from amphiphilic block copolymers can be further re-engineered to perform a controlled shape transformation from a thermodynamically stable spherical morphology to a kinetically trapped stomatocyte structure with co",{"id":152,"funder":7,"programme":8,"title":153,"piName":14,"institution":56,"country":57,"year":13,"amount":51,"abstract":154},"cordis-european-research-council-award-307379","Hybrid quantum networks for spin coherent technologies","Spins in solids are at the heart of fundamental physical phenomena such as magnetism. Today, they are harnessed in a range of technologies such as magnetic resonance imaging and spintronics for recording media. The revolutionary potential of future quantum technologies has fuelled research efforts to gain control of the quantum nature of spins. Thanks to a string of recent breakthroughs, it is now possible to initialize and read out individual spins in a solid, and to manipulate their dynamics u",{"id":156,"funder":7,"programme":8,"title":157,"piName":14,"institution":56,"country":57,"year":13,"amount":158,"abstract":159},"cordis-european-research-council-award-282690","RETHINKING CHINA’S COLLAPSE: LAND, DEVELOPMENT AND INSTITUTIONAL CREDIBILITY","€1,498,227","Although China has appeared as a globalizing force in every sense, many observers feel that its development might come to a grinding halt or even collapse, because of its lack of political reforms, rising inequality, and rampant corruption. Contradictorily, since the start of the reforms China has exhibited relatively high socio-economic and political stability.The proposed ERC project seeks to go beyond widely accepted dichotomous views on China’s development – be they on an impending collapse ",{"id":161,"funder":7,"programme":8,"title":162,"piName":14,"institution":163,"country":28,"year":13,"amount":164,"abstract":165},"cordis-european-research-council-award-278675","From pebbles to planets: towards new horizons in the formation of planets","MAX IV Laboratory, Lund University","€1,332,467","The goal of this ERC Starting Grant proposal is to make significant advances in our understanding of how planetesimals and gas giant planets form. I propose an ambitious research programme dedicated to answering three key questions at the frontier of planet formation theory: - How do mm-sized particles grow past the bouncing barrier? - What is the Initial Mass Function of planetesimals? - How do the cores of gas giants form and evolve?} I will address these questions using a combination of novel",{"id":167,"funder":7,"programme":8,"title":168,"piName":14,"institution":169,"country":12,"year":13,"amount":51,"abstract":170},"cordis-european-research-council-award-307948","Nature-Inspired Gold Catalytic Tools","UNIVERSITAT ZURICH","The study of biologically relevant processes heavily relays on “small molecules”. Thus, the demand for novel chemical probes is of highest importance not only for chemistry, but also for closely related disciplines such as biology, medicine or material science. As the construction of complex molecular architectures from chemical building blocks still remains a far-from-routine task, the development of methodologies to increase the control over chemical reactivity and achieve molecular complexity",{"id":172,"funder":7,"programme":8,"title":173,"piName":14,"institution":149,"country":57,"year":13,"amount":174,"abstract":175},"cordis-european-research-council-award-281964","Detection and interpretation of de novo mutations and structural genomic variations in mental retardation","€1,499,154","Mental retardation, like most common neurodevelopmental and psychiatric diseases, shows a strong genetic component, but these underlying genetic causes remain largely unknown. For a long time it was hypothesized that these kind of common diseases are mainly caused by common inherited genetic variants with reduced penetrance. In contrast to this common variant-common disease hypothesis, I here hypothesize that a large proportion of this so-called “missing heritability” for conditions such as ment",{"id":177,"funder":7,"programme":8,"title":178,"piName":14,"institution":63,"country":64,"year":13,"amount":179,"abstract":180},"cordis-european-research-council-award-282655","Do oral contraceptives alter women’s mate preferences?","€1,367,597","Worldwide, ~100 million women use oral contraceptives (OCs). Discontinuation of OC use due to concerns about possible side effects is common among women who do not intend to become pregnant. Many recent studies have reported that women using OCs and women not using OCs have different mate preferences, raising the possibility that OCs alter mate preferences. Although these findings have been widely reported in the popular press as evidence that OCs alter women’s mate preferences, the between-subj",{"id":182,"funder":7,"programme":8,"title":183,"piName":14,"institution":109,"country":110,"year":13,"amount":184,"abstract":185},"cordis-european-research-council-award-281748","Single Heart beat MApping of myocardial Performance, Activation, and Scar by ultrasound","€1,602,401","Heart failure affects about 2% of the European population with an annual mortality rate of 10%. Cardiac Resynchronization Therapy (CRT) has been proven to reduce morbidity and mortality and has become a recommended treatment. Optimal lead placement for CRT not only requires exact anatomically mapped information on the mechanical activation sequence to be corrected but also tissue viability and performance maps. Unfortunately, to date, no imaging technique allows building such maps non-invasively",{"id":187,"funder":7,"programme":8,"title":188,"piName":14,"institution":97,"country":21,"year":13,"amount":189,"abstract":190},"cordis-european-research-council-award-278428","GaN Quantum Devices for T-Ray Sources","€1,627,236","T-rays, often called terahertz radiation or submillimeter waves, are loosely defined as the wavelengths from 30 µm to 1,000 µm, or the frequencies from 10 THz to 300 GHz. This non-ionizing radiation appears as a harmless alternative to x-rays in medical, biological and security screening. Current solutions in terms of coherent sources of T-rays either require cryogenic temperatures or are relatively bulky equipments based on optically-pumped materials. The solid-state recourse consisting of GaAs",{"id":192,"funder":7,"programme":8,"title":193,"piName":14,"institution":97,"country":21,"year":13,"amount":194,"abstract":195},"cordis-european-research-council-award-280043","Engineering electronic quantum coherence and correlations in hybrid nanostructures","€1,780,442","Nanoelectronic devices can provide versatile and relatively simple systems to study complex quantum phenomena under well-controlled, adjustable conditions. Existing technologies enable the fabrication of low-dimensional nanostructures, such as quantum dots (QDs), in which it is possible to add or remove individual electrons, turn on and off interactions, and tune the properties of the confined electronic states, simply by acting on a gate voltage or by applying a magnetic field. The hybrid combi",{"id":197,"funder":7,"programme":8,"title":198,"piName":14,"institution":199,"country":21,"year":13,"amount":200,"abstract":201},"cordis-european-research-council-award-278234","New Directions in Dark Matter Phenomenology at the TeV scale","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€1,462,200","Dark Matter constitutes about 80% of the total matter of the Universe, yet almost nothing is known of its nature: despite the huge experimental and theoretical efforts of the last decades, its true identity is yet to be determined. The recent years and the next few years, however, see several experimental exploratory techniques approaching for the first time the TeV scale, in a multi-faceted attack to the problem: the Large Hadron Collider at CERN in particle physics, the PAMELA and AMS-02 satel",{"id":203,"funder":7,"programme":8,"title":204,"piName":14,"institution":97,"country":21,"year":13,"amount":205,"abstract":206},"cordis-european-research-council-award-278203","Wideband Quantum Optics with Josephson Junctions","€1,640,587","Circuit quantum optics (quantum optics with microwave photons in electronic circuits) has allowed to solve several hard problems in traditional quantum optics and to explore new physics. However, so far only one of two regimes of circuit quantum optics has been explored, the circuit quantum electrodynamics regime, where photons reside in electrical resonators.In this project we want to develop the other regime of circuit quantum optics, the wideband regime, where photons are wave packets propaga",{"id":208,"funder":7,"programme":8,"title":209,"piName":14,"institution":97,"country":21,"year":13,"amount":210,"abstract":211},"cordis-european-research-council-award-310472","Spatial Integration in Cell Cytoskeleton","€1,435,000","The functional coherence in multicellular arrangements depends on each cell’s ability to adapt its internal organisation to the spatial configuration of their microenvironment. The asymmetric distributions of cell compartments and peripheral domains define the cell polarity. In multicellular animals, the establishment of cell polarity is mainly regulated by the cell’s adhesions to its neighbours and to the surrounding extracellular matrix (ECM). How cells integrate all these cues in space and ti",{"id":213,"funder":7,"programme":8,"title":214,"piName":14,"institution":215,"country":39,"year":13,"amount":216,"abstract":217},"cordis-european-research-council-award-280140","Graphene Quantum Electromechanical Systems","RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN","€1,797,200","The aim of this project is to develop a new class of mechanically tunable quantum devices based on graphene. Adopting an innovative and interdisciplinary approach grounded on both engineering-based microsystem technology and low-temperature solid-state physics, we aim at gaining control over the mechanical and electromechanical properties of graphene nano-membranes and suspended graphene nanostructures, in the low and high strain regime.The main motivation for going in this direction is the expe",{"id":219,"funder":7,"programme":8,"title":220,"piName":14,"institution":85,"country":86,"year":13,"amount":40,"abstract":221},"cordis-european-research-council-award-278872","From Flat to Chiral: A unified approach to converting achiral aromatic compounds to optically active valuable building blocks","The stereoselective preparation of enantioenriched organic compounds of  high structural complexity and synthetic value, in an economically viable and expeditious manner, is one of the most important goals in contemporary Organic Synthesis. In this proposal, I present a unified and conceptually novel approach for the conversion of flat, aromatic heterocycles into highly valuable compounds for a variety of applications. This approach hinges upon a synergistic combination of the dramatic power of ",{"id":223,"funder":7,"programme":8,"title":224,"piName":14,"institution":225,"country":21,"year":13,"amount":51,"abstract":226},"cordis-european-research-council-award-278845","Modelling of Architectures Ruled by Coupled or Heightened Excited States","UNIVERSITE DE NANTES","The goal of the MARCHES project is to rationalise and optimize the interplay between electronically excited-states in complex molecular architectures. The simulation of the properties of large conjugated architectures is to be performed with ab initio tools explicitly taking into account environmental effects.  Though efficient methods able to tackle such task are to be conceived during this project, we aim to enlighten coupled excited-states so to pave the way towards chemically-intuitive desig",{"id":228,"funder":7,"programme":8,"title":229,"piName":14,"institution":230,"country":231,"year":13,"amount":232,"abstract":233},"cordis-european-research-council-award-307732","Towards the dependable cloud: Building the foundations for tomorrow's dependable cloud computing.","INESC ID - INSTITUTO DE ENGENHARIADE SISTEMAS E COMPUTADORES, INVESTIGACAO E DESENVOLVIMENTO EM LISBOA","PT","€1,076,084","Cloud computing is being increasingly adopted by individuals, organizations, and governments. However, as the computations that are offloaded to the cloud expand to societal-critical services, the dependability requirements of cloud services become much higher, and we need to ensure that the infrastructure that supports these services is ready to meet these requirements. In particular, this proposal tackles the challenges that arise from two distinctive characteristic of the cloud infrastructure",{"id":235,"funder":7,"programme":8,"title":236,"piName":14,"institution":45,"country":12,"year":13,"amount":14,"abstract":237},"cordis-european-research-council-award-306877","Intelligent Shape Modeling","Digital 3D content creation and modeling has become an indispensable part of our technology-driven society. Any modern design and manufacturing process involves manipulation of digital 3D shapes. Many industries have been long expecting ubiquitous 3D as the next revolution in multimedia. Yet, contrary to “traditional” media such as digital music and video, 3D content creation and editing is not accessible to the general public, and 3D geometric data is not nearly as wide-spread as it has been an",{"id":239,"funder":7,"programme":8,"title":240,"piName":14,"institution":241,"country":12,"year":13,"amount":242,"abstract":243},"cordis-european-research-council-award-278023","Real-time dynamics of correlated many-body systems","UNIVERSITE DE FRIBOURG","€1,493,178","Strongly correlated materials exhibit some of the most remarkable phenonomena found in condensed matter systems. They typically involve many active degrees of freedom (spin, charge, orbital), which leads to numerous competing states and complicated phase diagrams. A new perspective on correlated many-body systems is provided by the nonequilibrium dynamics, which is being explored in transport studies on nanostructures, pump-probe experiments on correlated solids, and in quench experiments on ult",{"id":245,"funder":7,"programme":8,"title":246,"piName":14,"institution":38,"country":39,"year":13,"amount":14,"abstract":247},"cordis-european-research-council-award-308125","Automatic Synthesis of Software Verification Tools from Proof Rules","Software complexity is growing, so is the demand for software verification.  Soon, perhaps within a decade, wide deployment of software verification tools will be indispensable or even mandatory to ensure software reliability in a large number of application domains, including but not restricted to safety and security critical systems.  To adequately respond to the demand we need to eliminate tedious aspects of software verifier development, while providing support for the accomplishment of crea",{"id":249,"funder":7,"programme":8,"title":250,"piName":14,"institution":102,"country":103,"year":13,"amount":251,"abstract":252},"cordis-european-research-council-award-309706","Evolutionary mechanisms of epigenomic and chromosomal aberrations in cancer","€1,499,998","Our working hypothesis is that tumorigenesis is an evolutionary process that fundamentally couples few major driving events (point mutations, rearrangements) with a complex flux of minor aberrations, many of which are epigenetic. We believe that these minor events are critical factors in the emergence of the cancer phenotype, and that understanding them is essential to the characterization of the disease. In particular, we hypothesize that a quantitative and principled evolutionary model for car",{"id":254,"funder":7,"programme":8,"title":255,"piName":14,"institution":102,"country":103,"year":13,"amount":51,"abstract":256},"cordis-european-research-council-award-281289","Uncovering the Mechanisms of Cardiomyocyte Differentiation and Dedifferentiation","The quest to restore damaged organs is one of the major challenges in medicine. Recent studies in both animals and in humans suggest that the heart has a limited capacity to replenish its own cardiomyocytes (CMs) throughout life, albeit inadequate to compensate for major injuries such as acute myocardial infarction (MI). Most therapeutic research in regenerative cardiogenesis is geared toward stem cell therapy as a means to replace lost CMs associated with ischemic heart disease. Clinical data e",{"id":258,"funder":7,"programme":8,"title":259,"piName":14,"institution":102,"country":103,"year":13,"amount":260,"abstract":261},"cordis-european-research-council-award-307260","The nature of cosmic explosions","€1,499,302","Cosmic explosions, the violent deaths of stars, play a crucial role in many of the most interesting open questions in physics today. These events serve as “cosmic accelerators” for ultra-high-energy particles that are beyond reach for even to most powerful terrestrial accelerators, as well as distant sources for elusive neutrinos. Explosions leave behind compact neutron stars and black hole remnants, natural laboratories to study strong gravity. Acting as cosmic furnaces, these explosions driven",{"id":263,"funder":7,"programme":8,"title":264,"piName":14,"institution":199,"country":21,"year":13,"amount":265,"abstract":266},"cordis-european-research-council-award-313339","Theology, Education, Scholastic Institution and Scholars-network: dialogues between the University of Paris and the new Universities from Central and Eastern Europe during the Late","€1,494,784","The THESIS project proposes a pioneering study of a coherent corpus of medieval manuscripts consisting of all the commentaries on the Sentences composed in Paris and in the new universities from Central Europe between 1350-1450. A Sentences commentary is a core component of the medieval academic curriculum, a collection of theses that scholars had to defend in the universities in order to obtain the title of master or doctor of theology; it is actually the unique equivalent of our modern PhD the",{"id":268,"funder":7,"programme":8,"title":269,"piName":14,"institution":102,"country":103,"year":13,"amount":51,"abstract":270},"cordis-european-research-council-award-309688","The Role of Elimination of Senescent Cells in Cancer Development","Cellular senescence, which is a terminal cell cycle arrest, is a potent tumor suppressor mechanism that limits cancer initiation and progression; it also limits tissue damage response. While senescence is protective in the cell autonomous manner, senescent cells secrete a variety of factors that lead to inflammation, tissue destruction and promote tumorigenesis and metastasis in the sites of their presence. Here we propose a unique approach – to eliminate senescent cells from tissues in order to",{"id":272,"funder":7,"programme":8,"title":273,"piName":14,"institution":102,"country":103,"year":13,"amount":274,"abstract":275},"cordis-european-research-council-award-306965","Clouds and Precipitation Response to Anthropogenic Changes in the Natural Environment","€1,428,169","Clouds and precipitation play a crucial role in the Earth's energy balance, global atmospheric circulation and the water cycle. Despite their importance, clouds still pose the largest uncertainty in climate research.I propose a new approach for studying anthropogenic effects on cloud fields and rain, tackling the challenge from both scientific ends: reductionism and systems approach. We will develop a novel research approach using observations and models interactively that will allow us to “peel",{"id":277,"funder":7,"programme":8,"title":278,"piName":14,"institution":102,"country":103,"year":13,"amount":279,"abstract":280},"cordis-european-research-council-award-307754","Comparing and Analyzing Collections of Surfaces","€1,113,744","The proposed research program intends to cover all aspects of the problem of learning and analyzing collections of surfaces and apply the developed methods and algorithms to a wide range of scientific data.The proposal has two parts:In the first part of the proposal, we concentrate on developing the most basic operators comparing automatically pairs of surfaces. Although this problem has receiveda lot of attention in recent years,and significant progress has been made, there is still a great nee",{"id":282,"funder":7,"programme":8,"title":283,"piName":14,"institution":74,"country":57,"year":13,"amount":284,"abstract":285},"cordis-european-research-council-award-278364","Phosphorus dynamics in low-oxygen marine systems: quantifying the nutrient-climate connection in Earth’s past, present and future","€1,498,000","Phosphorus (P) is a key and often limiting nutrient for phytoplankton in the ocean. A strong positive feedback exists between marine P availability, primary production and ocean anoxia: increased production leads to ocean anoxia, which, in turn, decreases the burial efficiency of P in sediments and therefore increases the availability of P and production in the ocean. This feedback likely plays an important role in the present-day expansion of low-oxygen waters (“dead zones”) in coastal systems ",{"id":287,"funder":7,"programme":8,"title":288,"piName":14,"institution":74,"country":57,"year":13,"amount":51,"abstract":289},"cordis-european-research-council-award-306390","New proxies to quantify continental climate development during the Pliocene","Atmospheric CO2 concentrations have risen rapidly since pre-industrial times and our current climate is not yet in equilibrium with this; it will change. To obtain insight in the type and magnitude of this change and to validate climate models used to project these changes, we need to look back at past climates. The most recent time in Earth history with CO2 levels that were similar to today is the Pliocene. The Pliocene thus provides a unique window into a world that exhibited many of the clima",{"id":291,"funder":7,"programme":8,"title":292,"piName":14,"institution":293,"country":39,"year":13,"amount":294,"abstract":295},"cordis-european-research-council-award-311339","Impact of virus infection on the host proteome","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€1,498,896","Pathogens exploit cellular resources for their own benefit and their propagation. Co-evolution of viruses and their hosts led to the establishment of very specific interactions between both partners. The balance between both, the viral attack and the cellular defense mechanisms, dictates the outcome of an infection, either leading to a cure, to disease or life-long co-existence. Efforts from many laboratories have focused on virus-host interactions, mostly by testing isolated protein-protein int",{"id":297,"funder":7,"programme":8,"title":298,"piName":14,"institution":38,"country":39,"year":13,"amount":14,"abstract":299},"cordis-european-research-council-award-306754","Real-time nanoscale optoelectronics","Is it possible to really ‘see’ how fast electrons flow in nanoscale optoelectronic circuits? Can we, in this way, get a complete understanding of the real-time dynamics of electrons in nanoscale circuits?The vision of this ERC proposal is to establish a research area at the interface of condensed matter physics, ultrafast optics, and electrical engineering which has so far been nearly completely unexplored: the investigation of real-time dynamics of photoexcited charge carriers in electrically c",{"id":301,"funder":7,"programme":8,"title":302,"piName":14,"institution":45,"country":12,"year":13,"amount":14,"abstract":303},"cordis-european-research-council-award-306733","Chemically Engineered Nanocrystal Solids","Many materials in the form of well-defined nanoscale crystals (“nanocrystals”) exhibit unique properties due to size effects and large surface-to-volume ratios. Yet it is clear that the utilization of nanomaterials in modern technologies requires their integration into solid-state structures with programmable electronic, magnetic and optical properties. The clear challenge is the rational design of this novel type of condensed matter, in which the size-tunable individual properties of nanoscale ",{"id":305,"funder":7,"programme":8,"title":306,"piName":14,"institution":45,"country":12,"year":13,"amount":51,"abstract":307},"cordis-european-research-council-award-309301","Three-dimensional Magnetic Resonance Imaging at Molecular Resolution","Determination of the atomic structure of large and complex macromolecules, indispensable for the understanding of the mechanisms of biological processes, is one of the most difficult problems in molecular biology. Examples of such structures include subcellular entities, giant protein and nucleic acid assemblies, molecular machines, fibrils, membrane proteins, as well as enveloped viruses and small bacteria. The standard tools for delivering structures at atomic resolution, X-ray crystallography",{"id":309,"funder":7,"programme":8,"title":310,"piName":14,"institution":45,"country":12,"year":13,"amount":311,"abstract":312},"cordis-european-research-council-award-307036","Large-scale Adaptive Sensing, Learning and Decision Making: Theory and Applications","€1,499,900","We address one of the fundamental challenges of our time: Acting effectively while facing a deluge of data. Massive volumes of data are generated from corporate and public sources every second, in social, scientific and commercial applications. In addition, more and more low level sensor devices are becoming available and accessible, potentially to the benefit of myriads of applications. However, access to the data is limited, due to computational, bandwidth, power and other limitations. Crucial",{"id":314,"funder":7,"programme":8,"title":315,"piName":14,"institution":45,"country":12,"year":13,"amount":316,"abstract":317},"cordis-european-research-council-award-306279","STRUCTURE PRESERVING APPROXIMATIONS FOR ROBUST COMPUTATION OF CONSERVATION LAWS AND RELATED EQUATIONS","€1,220,433","Many interesting systems in physics and engineering are mathematically modeled by first-order non-linear hyperbolic partial differential equations termed as systems of conservation laws. Examples include the Euler equations of aerodynamics, the shallow water equations of oceanography, multi-phase flows in a porous medium (used in the oil industry), equations of non-linear elasticity and the MHD equations of plasma physics. Numerical methods are the key tools to study these equations and to simul",{"id":319,"funder":7,"programme":8,"title":320,"piName":14,"institution":321,"country":14,"year":13,"amount":322,"abstract":323},"cordis-european-research-council-award-312474","Identification, Estimation and Implementation of Structural Economic Models","UNIVERSITY COLLEGE LONDON","€1,067,000","Structural economic models are getting increasingly complex. This complicates their implementation. In particular, for many models, (i) identification of the relevant components from data is still unresolved; (ii) estimation and testing procedures tend to be somewhat ad hoc and with no theoretical underpinning; (iii) the implementation of model and estimators often require numerical approximations since model solutions are not available on closed form.The proposed research aims at addressing the",{"id":325,"funder":7,"programme":8,"title":326,"piName":14,"institution":63,"country":64,"year":13,"amount":14,"abstract":327},"cordis-european-research-council-award-311751","Brain reading of contextual feedback and predictions","We are currently witnessing a paradigm shift in our understanding of human brain function, moving towards a clearer description of cortical processing. Sensory systems are no longer considered as 'passively recording' but rather as dynamically anticipating and adapting to the rapidly changing environment. These new ideas are encompassed in the predictive coding framework, and indeed in a unifying theory of the brain (Friston, 2010). In terms of brain computation, a predictive model is created in",{"id":329,"funder":7,"programme":8,"title":330,"piName":14,"institution":63,"country":64,"year":13,"amount":14,"abstract":331},"cordis-european-research-council-award-283873","Global traffic in illicit cultural objects: developing knowledge for improving interventions in a transnational criminal market","The research seeks to push the boundaries of our understanding of, and social and legal responses to, trafficking in illicit cultural objects. The global market in illicit cultural objects is a structure of relatively rich consumers at one end of the supply chain (collectors, dealers, museums) and relatively poor looters at the other end, in source countries characterised by high levels of the 'natural resource' of cultural objects and low levels of policing resource to devote to their protectio",{"id":333,"funder":7,"programme":8,"title":334,"piName":14,"institution":63,"country":64,"year":13,"amount":335,"abstract":336},"cordis-european-research-council-award-283670","The Fragments of the Republican Roman Orators","€1,161,451","This project gathers together, edits and interprets the surviving evidence for the orators of the Roman Republican period whose speeches do not survive in complete form. Its scope includes material which is, or is preserved as if it is, the actual words spoken by Republican orators as well as material about occasions when men spoke, who their audiences were, and the kinds of arguments they used in order to persuade. Cicero is the only Republican orator whose speeches are transmitted in their ent",{"id":338,"funder":7,"programme":8,"title":339,"piName":14,"institution":215,"country":39,"year":13,"amount":340,"abstract":341},"cordis-european-research-council-award-308051","Synthetic Expansion of Magnetic Molecules Into Spintronic Devices","€1,467,200","Molecular spintronics is emerging as a rapidly growing field at the interface of inorganic molecular chemistry, surface sciences, and condensed matter physics fueled by both the fundamental interest in the underlying charge and spin transport mechanisms, and the prospects of the combined exploitation of molecular charge and spin states in a revolutionary new class of molecular-based ultra-low power devices translating their spin\u002Fcharge response characteristics into novel, non-trivial functionali",{"id":343,"funder":7,"programme":8,"title":344,"piName":14,"institution":149,"country":57,"year":13,"amount":51,"abstract":345},"cordis-european-research-council-award-284108","The challenge of reduced pronunciation variants in conversational speech for foreign language listeners: experimental research and computational modeling","In today's Europe, people from different nationalities often collaborate, and, therefore have to learn to communicate in a foreign language. After several years of classes, learners are quite able to follow radio programs with clearly speaking presenters and to maintain calm conversations in the foreign language. In contrast, these learners still have great difficulties understanding everyday casual conversations. This is largely due to the reduced pronunciation variants that are ubiquitous in e",{"id":347,"funder":7,"programme":8,"title":348,"piName":14,"institution":215,"country":39,"year":13,"amount":349,"abstract":350},"cordis-european-research-council-award-307432","Computer Vision for Scene Understanding from a first-person Perspective","€1,499,960","The goal of CV-SUPER is to create the technology to perform dynamic visual scene understanding from the perspective of a moving human observer. Briefly stated, we want to enable computers to see and understand what humans see when they navigate their way through busy inner-city locations. Our target scenario is dynamic visual scene understanding in public spaces, such as pedestrian zones, shopping malls, or other locations primarily designed for humans. CV-SUPER will develop computer vision algo",{"id":352,"funder":7,"programme":8,"title":353,"piName":14,"institution":97,"country":21,"year":13,"amount":354,"abstract":355},"cordis-european-research-council-award-278472","Quantitative approaches for strongly correlated quantum systems in equilibrium and far from equilibrium","€1,130,800","Understanding electronic correlations remains one of the most important challenges in theoretical condensed matter physics.  The interaction-induced metal-to-insulator Mott transition plays a major role in many transition metal oxides, f-electron materials and now in quantum optics.  Upon doping or application of a strong electric field, strongly correlated Mott metals emerge from the Mott insulators, with fascinating properties.  Moreover, the out-of-equilibrium behaviour of these systems is on",{"id":357,"funder":7,"programme":8,"title":358,"piName":14,"institution":199,"country":21,"year":13,"amount":359,"abstract":360},"cordis-european-research-council-award-306387","Propagative and Internal Coherence in Semiconductor Nanostructures","€1,499,708","This project concerns the field of coherent, nonlinear, ultrafast light-matter interaction on a quantum level in solids. It proposes to experimentally explore limits of: i) internal coherence of an individual emitter",{"id":362,"funder":7,"programme":8,"title":363,"piName":14,"institution":364,"country":28,"year":13,"amount":365,"abstract":366},"cordis-european-research-council-award-279944","‘Filming’ excited state structural dynamics in photosynthesis and organic semiconductors","GOETEBORGS UNIVERSITET","€1,690,465","I wish to record ‘atomic movies’ of the structural quantum response in photoexcited chromophores.The structure of molecules relaxes as a response to photoexcitation. Coherent atomic relocations are thought to be important in photosynthesis and they ‘wire’ together distant electronic systems on conjugated polymer chains. The structural details of such atomic motions remain today elusive, because experimental techniques to visualize them are simply not available.I will pioneer femtosecond time-res",{"id":368,"funder":7,"programme":8,"title":369,"piName":14,"institution":199,"country":21,"year":13,"amount":14,"abstract":370},"cordis-european-research-council-award-278242","Extended fluorescence resonance energy transfer with plasmonic nanocircuits","Förster fluorescence resonance energy transfer (FRET) is one of the most popular methods to measure distance, structure, association, and dynamics at the single molecule level. However, major challenges are limiting FRET in several fields of physical and analytical sciences: (i) a short distance range below 8 nm, (ii) a concentration range in the nanomolar regime, and (iii) generally weak detected signals.At the interface between physical chemistry and nano-optics, the proposal objective is to e",{"id":372,"funder":7,"programme":8,"title":373,"piName":14,"institution":199,"country":21,"year":13,"amount":374,"abstract":375},"cordis-european-research-council-award-306312","Physical principles of recognition in the immune system.","€1,267,914","Receptor proteins on the surfaces of B- and T-cells interact with pathogens, recognize them and initiate an immune response. The diversity and complexity of immune receptors poses a challenge to nonequilibrium many-body physics and our understanding of the physical principles that control the emergent functional properties of biological systems, such as recognition. The diversity of the composition of the immune repertoire emerges as a self-organized process, stimulated by interactions with the ",{"id":377,"funder":7,"programme":8,"title":378,"piName":14,"institution":379,"country":380,"year":13,"amount":14,"abstract":381},"cordis-european-research-council-award-279529","Integrated Analysis & Design in Nonlinear Dynamics","DANMARKS TEKNISKE UNIVERSITET","DK","Imagine lighter and more fuel economic cars with improved crashworthiness that help save lives, aircrafts and wind-turbine blades with significant weight reductions that lead to large savings in material costs and environmental impact, and light but efficient armour that helps to protect against potentially deadly blasts. These are the future perspectives with a new generation of advanced structures and micro-structured materials.The goal of INNODYN is to bring current design procedures for stru",{"id":383,"funder":7,"programme":8,"title":384,"piName":14,"institution":109,"country":110,"year":13,"amount":385,"abstract":386},"cordis-european-research-council-award-284101","How the modularization of the mind unfolds in the brain","€1,474,800","The mind is not an unitary entity, nor is its physical substrate, the brain. Both can be divided into multiple components, some of which have been referred to as modules. Many controversies exist in cognitive science, psychology, and philosophy about the properties and the status of these modules. A compromise view is offered by an hypothesis of modularization which has two central tenets: (i) Genetic influences determine a weak non-modular organization of the mind and (ii) this map develops int",{"id":388,"funder":7,"programme":8,"title":389,"piName":14,"institution":97,"country":21,"year":13,"amount":51,"abstract":390},"cordis-european-research-council-award-306535","Single active dopant detection in semiconductor nanowires using electron holography","The end of happy scaling in the semiconductor industry has lead to innovation being a key parameter in nanoelectronics. Doped nanowires of all types of sizes, shapes and composition are now used as components to build nano-electronic devices, light sources, detectors and for photovoltaic applications. As these devices are reduced in size, the location of individual dopant atoms becomes more important and the behavior of only one or two atoms can dominate their properties. More recently, research",{"id":392,"funder":7,"programme":8,"title":393,"piName":14,"institution":149,"country":57,"year":13,"amount":394,"abstract":395},"cordis-european-research-council-award-283567","Perception and Action in Accelerating Environments","€1,495,750","Navigating through the environment evokes complex changes of visual, auditory, vestibular, tactile and motor inputs to the brain. Yet, despite this motion, we perceive the world as a stable reality, maintain an integrated sense of where we are, and are able to act rather effortlessly upon surrounding objects. To date, little is known about how the processes for perception and action are maintained dynamically. This project is concerned with the learning and control strategies for perception and ",{"id":397,"funder":7,"programme":8,"title":398,"piName":14,"institution":97,"country":21,"year":13,"amount":399,"abstract":400},"cordis-european-research-council-award-281287","Nuclear Dynamic, Organization and Genome Stability","€1,499,863","The eukaryotic genome is packaged into large-scale chromatin structures occupying distinct domains in the cell nucleus. Nuclear compartmentalization has recently been proposed to play an important role in genome stability but the molecular steps regulated remain to be defined. Focusing on Double strand breaks (DSBs) in response to which cells activate checkpoint and DNA repair pathways, we propose to characterize the spatial and temporal behavior of damaged chromatin and determine how this affec",{"id":402,"funder":7,"programme":8,"title":403,"piName":14,"institution":97,"country":21,"year":13,"amount":51,"abstract":404},"cordis-european-research-council-award-306398","Gathering organic and hybrid photovoltaics with artificial photosynthesis for Photo-Electro-Chemical production of hydrogen","The future of energy supply depends on innovative breakthroughs regarding the design of efficient systems for the conversion and storage of solar energy. The production of H2 through direct light-driven water-splitting in a Photo-Electro-Chemical (PEC) cell, appears as a promising solution. However such cells need to respond to three main characteristics: sustainability, cost-effectiveness and stability. Fulfilling these requirements raise important scientific questions regarding the elaboration",{"id":406,"funder":7,"programme":8,"title":407,"piName":14,"institution":63,"country":64,"year":13,"amount":408,"abstract":409},"cordis-european-research-council-award-312711","Gendering activism in populist radical right parties. A comparative study of women’s and men’s participation in the Northern League (Italy) and the National Front (France)","€228,674","Building on two pilot studies conducted in 2010, the proposed research will explore the gender dimensions of anti-immigration social movements in contemporary Europe. This will be done through a comparative analysis of activism in two populist radical right parties: an ethnographic and documentary study of activism in the social and cultural associations linked to the Northern League party (NL) in Italy and to the National Front party (NF) in France. During the applicant’s earlier research on th",{"id":411,"funder":7,"programme":8,"title":412,"piName":14,"institution":199,"country":21,"year":13,"amount":413,"abstract":414},"cordis-european-research-council-award-281604","Topographic signaling and spatial landmarks of key polarized neuro-developmental processes","€1,498,971","Polarization, which confers asymmetry at molecular, cellular and tissue scales, is a fascinating process establishing fundamental features of biological systems. In multicellular organisms, symmetry breaking triggers the specification of embryonic body axes, governing the positioning of subsequent morphogenetic processes. Cells and tissues acquire complex polarity features, which remarkably, are highly precisely positioned within the body axes. How are polarization processes spatially oriented r",{"id":416,"funder":7,"programme":8,"title":417,"piName":14,"institution":109,"country":110,"year":13,"amount":418,"abstract":419},"cordis-european-research-council-award-306471","Active Wind Farms: Optimization and Control of Atmospheric Energy Extraction in Gigawatt Wind Farms","€1,499,241","With the recognition that wind energy will become an important contributor to the world’s energy portfolio, several wind farms with a capacity of over 1 gigawatt are in planning phase. In the past, engineering of wind farms focused on a bottom-up approach, in which atmospheric wind availability was considered to be fixed by climate and weather. However, farms of gigawatt size slow down the Atmospheric Boundary Layer (ABL) as a whole, reducing the availability of wind at turbine hub height. In De",{"id":421,"funder":7,"programme":8,"title":422,"piName":14,"institution":102,"country":103,"year":13,"amount":51,"abstract":423},"cordis-european-research-council-award-309788","Decoding the Mammalian transcriptional Regulatory code in development and stimulatory responses","Transcription factors (TF) regulate genome function by controlling gene expression. Comprehensive characterization of the in vivo binding of TF to the DNA in relevant primary models is a critical step towards a global understanding of the human genome. Recent advances in high-throughput genomic technologies provide an extraordinary opportunity to develop and apply systematic approaches to learn the underline principles and mechanisms of mammalian transcriptional networks. The premise of this pro",{"id":425,"funder":7,"programme":8,"title":426,"piName":14,"institution":321,"country":14,"year":13,"amount":427,"abstract":428},"cordis-european-research-council-award-313716","Transmission of innovations: comparison and modelling of early farming and associated technologies in Europe","€1,499,832","This project will investigate the transmission of farming and associated technological innovations (landscape use, pottery, lithics) in the western Balkans during the 6th and 5th millennium BC through a combination of new data collection (archaeological field work, access to museum collections and literature survey), analysis and agent-based modelling. The research area provides a unique opportunity to observe the creation and initial dispersal of the two cultural streams (inland and maritime) r",{"id":430,"funder":7,"programme":8,"title":431,"piName":14,"institution":432,"country":39,"year":13,"amount":433,"abstract":434},"cordis-european-research-council-award-313623","Dynamic Approaches to Mergers and Industry Structure","UNIVERSITAET MANNHEIM","€1,304,640","I seek to increase our understanding of mergers, merger control and industry structure and propose to construct and analyse models that explicitly take into account the dynamic nature of the competitive process. In addition to making advances in modelling dynamic competition in oligopolistic markets and shedding light on policy-relevant questions in antitrust and industrial policy, I plan to make methodological contributions on dynamic bargaining with externalities and dynamic delegated agency t",{"id":436,"funder":7,"programme":8,"title":437,"piName":14,"institution":438,"country":380,"year":13,"amount":439,"abstract":440},"cordis-european-research-council-award-311278","Specificity Drift in The Kinome During Cancer Development and Evolution","KOBENHAVNS UNIVERSITET","€1,700,000","Cellular signaling networks have evolved to enable swift and accurate responses, even in the face of genetic or environmental perturbation. While we can readily assess dynamics in phosphorylation sites, our ability to model and predict the associated networks of kinases are hampered by the fact that we lack information on catalytic specificity for around 60% of the 538 human protein kinases (kinome). This translates into an even bigger gap in kinase-substrate relationships, where a phosphorylati",{"id":442,"funder":7,"programme":8,"title":443,"piName":14,"institution":444,"country":110,"year":13,"amount":445,"abstract":446},"cordis-european-research-council-award-307265","The Nonlinear Tuned Vibration Absorber","UNIVERSITE DE LIEGE","€1,316,440","Even after more than one century of flight, both civil and military aircraft are still plagued by major vibration problems. A well-known example is the external-store induced flutter of the F-16 fighter aircraft. Such dynamical phenomena, commonly known as aeroelastic instabilities, result from the transfer of energy from the free stream to the structure and can lead to limit cycle oscillations, a phenomenon with no linear counterpart. Since nonlinear dynamical systems theory is not yet mature, ",{"id":448,"funder":7,"programme":8,"title":449,"piName":14,"institution":450,"country":28,"year":13,"amount":451,"abstract":452},"cordis-european-research-council-award-310203","Mapping canine genes and pathways to leverage personalized treatment options","UPPSALA UNIVERSITET","€1,499,365","The domestic dog encompasses hundreds of genetically isolated breeds, many of which show an increased risk for certain diseases. With the canine genome sequence, an understanding of the haplotype structure and availability of disease gene mapping tools, we are now in a unique position to map canine disease genes to inform human biology and medicine. So far we have mapped monogenic traits as well as >40 loci for >10 complex traits. We now propose to map genes for key diseases using many breeds to",{"id":454,"funder":7,"programme":8,"title":455,"piName":14,"institution":199,"country":21,"year":13,"amount":456,"abstract":457},"cordis-european-research-council-award-306661","Gain-endowed metallic meta-structures and devices: towards a unification of photonics and electronics","€1,497,248","This research project aims at building a common framework for photonic and meta-material \u002Felectronic devices. As specific examples, we will focus on making key advances for THz and mid-infrared emitters and detectors. Our goal is to demonstrate device functionalities which cannot be achieved within the current scientific\u002Ftechnological framework.We will implement these concepts on quantum cascade lasers, a family of devices whose potential has seen an explosion in the last few years. They cover t",{"id":459,"funder":7,"programme":8,"title":460,"piName":14,"institution":199,"country":21,"year":13,"amount":461,"abstract":462},"cordis-european-research-council-award-281605","Evolution of gene mobility: how mobile elements shape the function and sociality of microbial communities","€1,298,925","Prokaryotes evolve rapidly new functionalities by horizontal gene transfer delivered by mobile genetic elements (MGE). MGE increase relatedness between individuals and thereby might also promote the establishment of microbial social networks. Many studies have detailed the dynamics of specific systems in specific MGE. Yet, how MGE key and accessory functions evolve as a whole at the face of social dilemmas arising in microbial communities is largely ignored. Here, I aim at an integrative identif",{"id":464,"funder":7,"programme":8,"title":465,"piName":14,"institution":466,"country":467,"year":13,"amount":468,"abstract":469},"cordis-european-research-council-award-282106","Transporter pharmacogenomics – the contribution of transporters to variability in drug response","HELSINGIN YLIOPISTO","FI","€1,882,212","The response to drug therapy varies widely between individuals. Proteins involved in the absorption, distribution, metabolism and excretion of drugs play a central role in determining the concentration of a drug at the target site, and thus drug efficacy and toxicity. Transporters are membrane proteins that mediate the translocation of chemicals into and out of cells using active and passive mechanisms. We have identified a single nucleotide variant in the SLCO1B1 gene encoding the organic anion",{"id":471,"funder":7,"programme":8,"title":472,"piName":14,"institution":473,"country":21,"year":13,"amount":51,"abstract":474},"cordis-european-research-council-award-281265","Induction of Insulin-producing beta-cells Regeneration in vivo","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","Diabetes has become one of the most widespread metabolic disorders with epidemic dimensions affecting almost 6% of the world’s population. Despite modern treatments, the life expectancy of patients with Type 1 diabetes remains reduced as compared to healthy subjects. There is therefore a need for alternative therapies. Towards this aim, using the mouse, we recently demonstrated that the in vivo forced expression of a single factor in pancreatic alpha-cells is sufficient to induce a continuous re",{"id":476,"funder":7,"programme":8,"title":477,"piName":14,"institution":199,"country":21,"year":13,"amount":478,"abstract":479},"cordis-european-research-council-award-307087","Statistical Physics Approach to                                    Reconstruction in Compressed Sensing","€1,077,960","Compressed sensing is triggering a major evolution in signal acquisition: it indicates that most data, signals and images, that are usually compressible and have redundancy, can be reconstructed from much fewer measurements than what was usually considered necessary, resulting in a drastic gain of time, cost, and measurement precision. In order to make this groundbreaking improvement possible, compressed sensing deals with how measurements should be performed, and how, in a second step, to use c",{"id":481,"funder":7,"programme":8,"title":482,"piName":14,"institution":199,"country":21,"year":13,"amount":483,"abstract":484},"cordis-european-research-council-award-306633","Polarization condEnsation for Telecom AppLications","€1,452,818","The aim of the PETAL project is to provide a radically novel approach to polarization control issues and to transform this parameter into an additional fully exploited asset rather than a problem to be avoided. While current opto-electronic technologies are principally based on complex active-feedback loop control and algorithms, the breakthrough idea of PETAL is to explore a new type of phenomenon based on the unexpected ability of light to self-pull, self-trap and self-stabilize its own polari",{"id":486,"funder":7,"programme":8,"title":487,"piName":14,"institution":466,"country":467,"year":13,"amount":399,"abstract":488},"cordis-european-research-council-award-281559","A cross-species neurogenomics approach to anxiety","My goal is to identify novel genetic factors that regulate normal and pathological anxiety. Anxiety disorders are complex diseases with genetic and environmental susceptibility factors. Stressful life events, especially in childhood are well-known risk factors for anxiety disorders. We have previously used inbred mouse strains to identify genes underlying innate anxiety. Here I propose a new approach using a mouse model of anxiety induced by social stress to identify gene regulatory networks, to",{"id":490,"funder":7,"programme":8,"title":491,"piName":14,"institution":466,"country":467,"year":13,"amount":492,"abstract":493},"cordis-european-research-council-award-281720","Transcriptional networks in glucose sensing","€1,496,930","Glucose is key source of nutritional energy and raw material for biosynthetic processes. Maintaining glucose homeostasis requires a regulatory network that functions both in the systemic level through hormonal signaling and locally at the intracellular level. Insulin signalling is the main hormonal mechanism involved in maintaining the levels of circulating glucose through regulation of cellular glucose intake and metabolism. While the signalling pathways mediating the effects of insulin have be",{"id":495,"funder":7,"programme":8,"title":496,"piName":14,"institution":450,"country":28,"year":13,"amount":51,"abstract":497},"cordis-european-research-council-award-311413","Following the Genomic Footprints of Early Europeans","Two of greatest challenges of the post-genomic era are to (i) develop a detailed understanding of the heritable variation in the human genome, and to (ii) determine which key events in human evolutionary history that are responsible for patterns of genomic variation. The recent genomic revolution will be instrumental in these quests and we will very soon have access to several thousand complete genomes from diverse populations.Extracting genetic information from ancient material has for long bee",{"id":499,"funder":7,"programme":8,"title":500,"piName":14,"institution":450,"country":28,"year":13,"amount":501,"abstract":502},"cordis-european-research-council-award-310039","Solving an evolutionary jigsaw puzzle: A next-generation genomics approach to trace the origins of the eukaryotic cell","€1,721,440","The origin of the eukaryotic cell represents an enigmatic yet dramatically incomplete evolutionary puzzle. The few pieces of this puzzle that we have managed to identify thus far indicate that the eukaryotic cell most probably emerged via a fusion of an archaeal and an alphaproteobacterial cell. Yet, beyond this, scientific debate is mainly engulfed by speculation, which, to a large extent, is fed by our poor understanding of the identity of these bacterial and archaeal fusion partners. In the c",{"id":504,"funder":7,"programme":8,"title":505,"piName":14,"institution":506,"country":507,"year":13,"amount":508,"abstract":509},"cordis-european-research-council-award-307940","Statistical Mechanics of Active Matter","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","IT","€1,448,400","The study of living matter has to be considered as an exciting and substantivepart of the modern definition of physics. Whether a general statisticalmechanics exists for broad classes of of active systems and what is thequantitative predictive power that we could expect from those theories remainstill open and debated questions. Reductionism and approximations, the mostpowerful weapons of theoretical physicists have to face a degree of complexitythat has no analogue in non living matter. That re",{"id":511,"funder":7,"programme":8,"title":512,"piName":14,"institution":466,"country":467,"year":13,"amount":513,"abstract":514},"cordis-european-research-council-award-310930","Actin as the Master Organizer of Nuclear Structure and Function","€1,491,484","Unlike previously thought the nucleus is a highly compartmentalized organelle. Both the genome and processes associated with it show non-random distribution within the nucleus. This compartmentalization has a fundamental impact on nuclear processes. However, the mechanisms driving this organization are poorly understood. I hypothesize that actin plays a key  role in this process. Nevertheless, the true potential of nuclear actin has not been fully appreciated, due to two fundamental open questio",{"id":516,"funder":7,"programme":8,"title":517,"piName":14,"institution":518,"country":507,"year":13,"amount":519,"abstract":520},"cordis-european-research-council-award-284119","Labor Heterogeneity in Search Markets","EUROPEAN UNIVERSITY INSTITUTE","€1,170,000","The work laid out in this proposal aims to change our understanding of labor markets by viewing both the mobility as well as the frictions in the market as a consequence of long-term worker heterogeneity. Despite the advances in information technology which substantially reduce the costs of sending information (job advertisements, job applications) extracting the relevant information about worker quality remains hard. Long-term differences in ability coupled with screening frictions are proposed",{"id":522,"funder":7,"programme":8,"title":523,"piName":14,"institution":524,"country":507,"year":13,"amount":525,"abstract":526},"cordis-european-research-council-award-308136","Polariton condensates: from fundamental physics to quantum based devices","CONSIGLIO NAZIONALE DELLE RICERCHE","€1,482,600","Polaritons are quantum superpositions of light and matter which combine appealing properties of both: the high coherence of photons and the strong interaction (non-linearities) of electrons. With the report of their Bose-Einstein condensation in 2006, they stand as one of the most exciting semiconductor-optical system of today. Given their peculiar character, they encompass different interdisciplinary areas of research which spans from the physics of phase transitions, critical phenomena and str",{"id":528,"funder":7,"programme":8,"title":529,"piName":14,"institution":450,"country":28,"year":13,"amount":530,"abstract":531},"cordis-european-research-council-award-306474","Harnessing Proto-Enzymes for Novel Catalytic Functions","€1,497,667","Enzymes are Nature’s catalysts, reducing the timescales of the chemical reactions that drive life from millions of years to seconds. There is also great scope for enzymes as biocatalysts outside the cell, from therapeutic and synthetic applications, to bioremediation and even for the generation of novel biofuels. Recent years have seen several impressive breakthroughs in the design of artificial enzymes, particularly through experimental studies that iteratively introduce random mutations to ref",{"id":533,"funder":7,"programme":8,"title":534,"piName":14,"institution":535,"country":64,"year":13,"amount":14,"abstract":536},"cordis-european-research-council-award-279802","CO2VOLC: Quantifying the global volcanic CO2 cycle","THE UNIVERSITY OF MANCHESTER","Global climate change induced by anthropogenic emissions of CO2 is currently a major issue facing humanity, but uncertainties in the magnitude and rate of climate change remain, and deterministic predictions are beyond our capacity. In this context, the study of how the geochemical carbon cycle established a relatively narrow band of variability in atmospheric CO2 concentrations over the last 400 ka is of great interest. However, large uncertainties in both weathering and volcanic CO2 fluxes pre",{"id":538,"funder":7,"programme":8,"title":539,"piName":14,"institution":540,"country":541,"year":13,"amount":542,"abstract":543},"cordis-european-research-council-award-283634","Emergence and decline of constructive memory – Life-span changes in a common brain network for imagination and episodic memory","UNIVERSITETET I OSLO","NO","€1,499,088","The creation of personal, episodic memory from a previous experience is a remarkably complex process, which substantially differs from the processes leading to non-personal knowledge and memory about the world, so-called semantic memory. The act of remembering an episodic event is as much an act of creation as an act of reproduction. Modality-specific memory items are assembled through a re-construction process that allows us to re-experience the episode in rich details. Recent research has show",{"id":545,"funder":7,"programme":8,"title":546,"piName":14,"institution":540,"country":541,"year":13,"amount":547,"abstract":548},"cordis-european-research-council-award-283236","General Institutional Equilibrium- theory and policy implications","€760,170","Existing institutional theory, including political economics and contract theory, convincingly show that institutional details have large impacts on economic and policy outcomes. Once this is recognized, it follows that contracts should depend on the organisational design of the institution to which the contract is offered. Stage 1 of Project Gine aims at characterising optimal contracts as a function of this design. Stage 2 develops a framework for endogenising and characterising the optimal in",{"id":550,"funder":7,"programme":8,"title":551,"piName":14,"institution":535,"country":64,"year":13,"amount":552,"abstract":553},"cordis-european-research-council-award-283626","Arabic Commentaries on the Hippocratic Aphorisms","€1,499,968","The Hippocratic Aphorisms have exerted a singular influence over generations of physicians both in the East and in the West. Galen (d. c. 216) produced an extensive commentary on this text, as did other medical authors writing in Greek, Latin, Arabic, and Hebrew. The Arabic tradition is particularly rich, with more than a dozen commentaries extant in over a hundred manuscripts. These Arabic commentaries did not merely contain scholastic debates, but constituted important venues for innovation an",{"id":555,"funder":7,"programme":8,"title":556,"piName":14,"institution":535,"country":64,"year":13,"amount":14,"abstract":557},"cordis-european-research-council-award-305868","Lewis Acidic Borocations:  improving Suzuki couplings, Material synthesis, Alkylation and Radical Transformations","Carbon-carbon bond formation is arguably the most important reaction in synthetic chemistry, exemplified by the award of five noble prizes. The most recent Nobel prize was awarded for the development of palladium catalysed cross coupling, of which Suzuki cross coupling is the most widely applied version in industry and academia and utilizes organo-boronates (RB(OR)2) as the nucleophilic component. The aims of this project are",{"id":559,"funder":7,"programme":8,"title":560,"piName":14,"institution":540,"country":541,"year":13,"amount":561,"abstract":562},"cordis-european-research-council-award-278011","Structure and scaling in computational field theories","€1,100,000","The numerical simulations that are used in science and industry require ever more sophisticated mathematics. For the partial differential equations that are used to model physical processes, qualitative properties such as conserved quantities and monotonicity are crucial for well-posedness. Mimicking them in the discretizations seems equally important to get reliable  results.This project will contribute to the interplay of geometry and numerical analysis by bridging the gap between Lie group ba",{"id":564,"funder":7,"programme":8,"title":565,"piName":14,"institution":566,"country":21,"year":13,"amount":567,"abstract":568},"cordis-european-research-council-award-283617","Corpses of Genocide and Mass Violence: Interdisciplinary and Comparative Approaches of Dead Bodies Treatment in the 20th Century (Destruction, Identification, Reconciliation)","ECOLE DES HAUTES ETUDES EN SCIENCES SOCIALES","€1,197,367","In Europe and all over the world, genocide and mass violence have been a structural feature of the 20th century. This project aims at questioning the social legacy of mass violence by studying how different societies have coped with the first consequence of mass destruction: the mass production of cadavers.  What status and what value have indeed been given to corpses? What political, social or religious uses have been made of dead bodies in occupied Europe, Soviet Union, Serbia, Spain but also ",{"id":570,"funder":7,"programme":8,"title":571,"piName":14,"institution":450,"country":28,"year":13,"amount":572,"abstract":573},"cordis-european-research-council-award-282330","Sequence based strategies to identify genetic variation associated with mental retardation and schizophrenia","€1,496,574","Mental retardation (MR) and schizophrenia (SCZ) are disorders of the brain that affect 2-3% and 1% of the population, respectively. Both disorders are considered to be highly heritable, but exhibit heterogeneous genetic etiology. Recent genetic studies have led to discoveries that the same variants that can give rise to different neuropsychiatric disorders, including MR and SCZ. In this proposal, sequencing will be used to identify novel genes involved in MR and SCZ, and to explore the potential",{"id":575,"funder":7,"programme":8,"title":576,"piName":14,"institution":577,"country":64,"year":13,"amount":578,"abstract":579},"cordis-european-research-council-award-312602","Architecture and Asceticism: Cultural Interaction between Syria and Georgia in Late Antiquity","THE UNIVERSITY OF EXETER","€954,523","The proposed research is intended to initiate the process of formulating an integrated approach to the evolution and spread of early Christianity in the Eastern Mediterranean, Caucasus and Middle East. Thus far this work has been constrained by geographical, linguistic and denominational boundaries meaning that there has been a plethora of regional studies in the field but no comprehensive overview attempting to develop a coherent picture of wider cultural interaction. By beginning a project tha",{"id":581,"funder":7,"programme":8,"title":582,"piName":14,"institution":583,"country":584,"year":13,"amount":585,"abstract":586},"cordis-european-research-council-award-281920","Dissecting the gene regulatory mechanisms that generate serotonergic neurons and their link to mental disorders","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","ES","€1,931,621","Mental disorders constitute a human an economic burden for developed countries. Many mental disorders are linked to serotonin dysfunction, but the exact mechanism underlying these disorders is not well understood. Serotonin Related Mental Disorders (SRMD) are multigenic, making the identification of these mechanisms a difficult task. Understanding the molecular mechanisms that generate serotonergic neurons will provide us with the tools to identify mutations that could predispose to SRMD. In thi",{"id":588,"funder":7,"programme":8,"title":589,"piName":14,"institution":583,"country":584,"year":13,"amount":590,"abstract":591},"cordis-european-research-council-award-307081","Polymer-Inorganic Flexible Nanostructured Films for the Control of Light","€1,497,730","The POLIGHT project will focus on the integration of a series of inorganic nanostructured materials possessing photonic or combined photonic and plasmonic properties into polymeric films, providing a significant advance with respect to current state of the art in flexible photonics. These highly adaptable films could act either as passive UV-Vis-NIR selective frequency mirrors or filters, or as matrices for light absorbing or optically active species capable of tailoring their optical response. ",{"id":593,"funder":7,"programme":8,"title":594,"piName":14,"institution":595,"country":110,"year":13,"amount":596,"abstract":597},"cordis-european-research-council-award-307074","Critical phenomena in random matrix theory and integrable systems","UNIVERSITE CATHOLIQUE DE LOUVAIN","€1,130,400","The main goal of the project is to create a research group on critical phenomena in random matrix theory and integrable systems at the Université Catholique de Louvain, where the PI was recently appointed.Random matrix ensembles, integrable partial differential equations and Toeplitz determinants will be the main research topics in the project. Those three models show intimate connections and they all share certain properties that are, to a large extent, universal. In the recent past it has been",{"id":599,"funder":7,"programme":8,"title":600,"piName":14,"institution":583,"country":584,"year":13,"amount":601,"abstract":602},"cordis-european-research-council-award-306826","Surface Self-Assembled Molecular Electronic Devices: Logic Gates, Memories and Sensors","€1,499,675","Organic electronic devices, such as organic field-effect transistors (OFETs), are raising an increasing interest for their potential in large area coverage and low cost applications. Also, the use of single molecules as active electronic components offers great prospects for the miniaturization of devices and for their compatibility with biological systems. Within this framework, e-GAMES goals are:1) Molecular logic gates for the storage and transmission of magnetic and optical information and f",{"id":604,"funder":7,"programme":8,"title":605,"piName":14,"institution":606,"country":57,"year":13,"amount":14,"abstract":607},"cordis-european-research-council-award-284364","Embodied Emotion Regulation","STICHTING VU","In everyday life, people frequently engage in bodily activities to regulate their emotions, such as physical exercise to reduce stress, eating tasty foods to improve one's mood, or practice meditation to achieve deep states of relaxation. In spite of such widespread practices, the wisdom of using the body in emotion regulation is highly contested within psychological science. Some studies have shown that people may successfully control their emotions through bodily exercies such as muscle relaxa",{"id":609,"funder":7,"programme":8,"title":610,"piName":14,"institution":611,"country":57,"year":13,"amount":51,"abstract":612},"cordis-european-research-council-award-279931","Quantum Optics with Spins in Solid State: The Power of Ensembles","RIJKSUNIVERSITEIT GRONINGEN","Quantum states of optical pulses can be controlled with great accuracy, and in solid state precise control over quantum states of spins has been achieved. Conversion of such optical quantum states into spin quantum states, and vice versa, is highly relevant for quantum information science, but appears to be more challenging. This proposal aims at a study of such quantum-state conversion, and at developing it into a fast and robust technique with high fidelity. The project builds on the establish",{"id":614,"funder":7,"programme":8,"title":615,"piName":14,"institution":611,"country":57,"year":13,"amount":51,"abstract":616},"cordis-european-research-council-award-309782","Novel tools to read and write the epigenetic code in inflammation","Chronic inflammatory diseases, such as, for example, asthma, afflict millions of people worldwide. Nevertheless, the molecular mechanisms that drive inflammation remain poorly understood. Enzymes play a crucial regulatory role in inflammation and represent potential drug targets. Nevertheless, the activities of these enzymes are poorly studied due to a lack of convenient tools for modulation and detection. The importance of this issue is demonstrated by my previous work on small molecule probes ",{"id":618,"funder":7,"programme":8,"title":619,"piName":14,"institution":611,"country":57,"year":13,"amount":620,"abstract":621},"cordis-european-research-council-award-281098","Under the hood: Single-molecule studies of the DNA replication machinery","€2,000,000","The study of biological processes at the single-molecule level has greatly influenced our view of the molecular mechanisms that define life. However, studies so far have mainly focused on individual, purified proteins in non-physiological environments. Since cellular processes are typically not mediated by single proteins, but rather by large complexes of dynamically interacting components, the development of the tools to study such large complexes with single-molecule sensitivity is an importan",{"id":623,"funder":7,"programme":8,"title":624,"piName":14,"institution":535,"country":64,"year":13,"amount":625,"abstract":626},"cordis-european-research-council-award-282059","Progression factors in melanoma leading to novel therapeutic targets","€1,498,500","Presently, there is little hope of cure for patients with metastatic melanoma. Greater insight into the molecular and cellular biology of melanoma and the immune response mounted against it is required to indicate new therapeutic approaches. We have created zebrafish models for analyzing melanoma initiation and progression. Using whole genome transcriptome profiling, we have identified a number of genes that are induced during malignant progression. Moreover, we have established an efficient met",{"id":628,"funder":7,"programme":8,"title":629,"piName":14,"institution":630,"country":39,"year":13,"amount":631,"abstract":632},"cordis-european-research-council-award-277749","Elliptic Pdes and Symmetry of Interfaces and Layers for Odd Nonlinearities","FORSCHUNGSVERBUND BERLIN EV","€850,000","The scope of this project is to perform an analytical study of the geometric properties of the interafaces arising in the scalar Ginzburg-Landau-Allen-Cahn equation, with particular attention to possible 1D symmetries.Also, we would like to analyze the cases in which the operator is singular, degenrate, subelliptic or fractional and to obtain results for PDEs in manifold and in inverse overdetermined problems, since all these models share some important features with classical semilinear PDEs an",{"id":634,"funder":7,"programme":8,"title":635,"piName":14,"institution":473,"country":21,"year":13,"amount":14,"abstract":636},"cordis-european-research-council-award-311542","Deciphering cytosolic antibacterial immunity: from triggering bacteriolysis to Aim2 inflammasome activation","Bacteria replicating within host cells either multiply in membrane-bound compartment or escape into the host cytosol. The host cytosol has long been considered as a safe haven for bacteria. However, the host cytosol is armed with an array of innate immune receptors detecting cytosolic invasion. Furthermore, the macrophage cytosol displays a bacteriolytic activity, which is inducible by IFN. Surprisingly, the molecular mechanisms of this innate immune effector response are still largely uncharact",{"id":638,"funder":7,"programme":8,"title":639,"piName":14,"institution":611,"country":57,"year":13,"amount":51,"abstract":640},"cordis-european-research-council-award-282083","Minimalist multipurpose ATP-binding cassette transporters","Many Gram-positive (pathogenic) bacteria are dependent on the uptake of vitamins from the environment or from the infected host. We have recently discovered the long-elusive family of membrane protein complexes catalyzing such transport. The vitamin transporters have an unprecedented modular architecture consisting of a single multipurpose energizing module (the Energy Coupling Factor, ECF) and multiple exchangeable membrane proteins responsible for substrate recognition (S-components). The S-co",{"id":642,"funder":7,"programme":8,"title":643,"piName":14,"institution":644,"country":64,"year":13,"amount":14,"abstract":645},"cordis-european-research-council-award-306559","Light in moving media","HERIOT-WATT UNIVERSITY","The interaction of light with matter is traditionally studied in media that are either still or moving at a negligible fraction of the speed of light. In this regime standard text-book results apply. However, if the medium or, more generally speaking, certain parameters that distinguish the medium such as the refractive index are made to change or move close to the speed of light then new and unexpected scenarios emerge. For example, if the medium refractive index is not moving but is made to os",{"id":647,"funder":7,"programme":8,"title":648,"piName":14,"institution":649,"country":110,"year":13,"amount":14,"abstract":650},"cordis-european-research-council-award-281600","Signaling and activation pathways of the NOD-like receptors Ipaf, Nlrp1b and Nlrp12","VIB VZW","My overall aim is to define the role of NOD-like receptors (NLRs) in immunity and to understand the importance of their signaling networks in health and disease.NLR family members are thought to sense pathogens and endogenous alarmins in intracellular compartments to trigger innate immune responses. Recent progress was made in mapping the signaling pathways of the NLRs Nod1, Nod2 and Nlrp3, but the roles and signaling cascades of most other NLRs remain unclear. Indeed, the NLRs Ipaf and Nlrp1b a",{"id":652,"funder":7,"programme":8,"title":653,"piName":14,"institution":649,"country":110,"year":13,"amount":654,"abstract":655},"cordis-european-research-council-award-310368","The role of loss-of-heterozygosity in cancer development and progression","€1,498,764","Somatically acquired loss-of-heterozygosity (LOH) is extremely common in cancer; deletions of recessive cancer genes, miRNAs, and regulatory elements, can confer selective growth advantage, whereas deletions over fragile sites are thought to reflect an increased local rate of DNA breakage. However, most LOHs in cancer genomes remain unexplained. Here we plan to combine a TALEN technology and the experimental models of cell transformation derived from primary human cells to delete specific chromo",{"id":657,"funder":7,"programme":8,"title":658,"piName":14,"institution":659,"country":12,"year":13,"amount":660,"abstract":661},"cordis-european-research-council-award-281996","Inflammatory signals emerging from the endoplasmic reticulum","UNIVERSITE DE LAUSANNE","€1,498,076","The endoplasmic reticulum (ER) serves many general functions, including the facilitation of protein folding and the transport of synthesized proteins, but it also has an important and more specialized role in sensing cellular stress. ER-stress identifies a group of signals that induce a transcriptional program enabling cells to survive protein overload and injury in the ER. This highly coordinated response involves three parallel signaling branches localized at the ER, namely IRE1, ATF6 and PERK",{"id":663,"funder":7,"programme":8,"title":664,"piName":14,"institution":665,"country":39,"year":13,"amount":14,"abstract":666},"cordis-european-research-council-award-282333","Xenophagy and bacterial avoidance","JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN","Autophagy is an essential process that enables cells to engulf and digest portions of their cytoplasm, thereby accomplishing quality and quantity control of organelles, proteins and pathogens. These homeostatic and adaptive function intricately link autophagy to diverse health and disease states including innate immunity. Microbial pathogens that successfully parasitize eukaryotic cells have evolved to evade autophagic microbial defenses (xenophagy) and subvert the host autophagic responses for ",{"id":668,"funder":7,"programme":8,"title":669,"piName":14,"institution":670,"country":380,"year":13,"amount":456,"abstract":671},"cordis-european-research-council-award-282163","Comparative studies of inbreeding effects on evolutionary processes in non-model animal populations","AARHUS UNIVERSITET","Comparative studies of inbreeding and evolution in non-model animal populations: a research proposal directed towards integrating ecological and evolutionary research on inbreeding. Specifically, my aim is to apply novel ecogenomics tools in the study of evolutionary consequences of inbreeding in non-model animal populations. At present, our understanding of inbreeding is dominated by studies of a small number of model organisms. I will undertake comparative studies on inbreeding effects in a ge",{"id":673,"funder":7,"programme":8,"title":674,"piName":14,"institution":675,"country":64,"year":13,"amount":676,"abstract":677},"cordis-european-research-council-award-280183","COLOR Ordering Templated by Hierarchized Supramolecular Porous FlatLANDS","CARDIFF UNIVERSITY","€1,295,400","The idea of this research project is to take advantage of molecular self-assembly to create a new generation of periodically-organized porous organic materials that, acting as specific molecular hosts, can structurally control the positioning of multiple functional guests on surfaces, opening new horizons toward the understanding and development of rationale protocols for the patterning of unprecedented materials. Taking advantage of a supramolecular approach to engineer extended mono- and two-d",{"id":679,"funder":7,"programme":8,"title":680,"piName":14,"institution":681,"country":39,"year":13,"amount":682,"abstract":683},"cordis-european-research-council-award-280565","Peripheral and Central Mechanisms of Temperature Detection and Core Body Thermoregulation","UNIVERSITATSKLINIKUM HEIDELBERG","€1,400,725","Internal temperature homeostasis is of critical importance to our health as deviation from a normal, tightly controlled level (37 °Celsius) can cause fatal organ failures. Temperature-sensitive cells in the hypothalamus detect deep brain temperature, which is directly relevant to core body temperature (CBT) regulation. However molecules and mechanisms underlying central temperature detection by hypothalamic neurons are unknown. I propose to use a multi-disciplinary approach to elucidate mechanis",{"id":685,"funder":7,"programme":8,"title":686,"piName":14,"institution":687,"country":28,"year":13,"amount":51,"abstract":688},"cordis-european-research-council-award-282220","NOVEL STRATEGIES FOR BRAIN REGENERATION","KAROLINSKA INSTITUTET","In contrast to mammals, newts possess exceptional capacities among vertebrates to rebuild complex structures, such as the brain. Our goal is to bridge the gap in the regenerative outcomes between newts and mammals. My group has made significant contributions towards this goal. We created a novel experimental system, which recapitulates central features of Parkinson’s disease in newts, and provides a unique model for understanding regeneration in the adult midbrain. We showed an unexpected but ke",{"id":690,"funder":7,"programme":8,"title":691,"piName":14,"institution":692,"country":57,"year":13,"amount":51,"abstract":693},"cordis-european-research-council-award-281322","Closing in on Runx3 and CXCL4 to open novel avenues for therapeutic intervention in systemic sclerosis","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","Systemic sclerosis (SSc) is an autoimmune disease that culminates in excessive extra-cellular matrix deposition (fibrosis) in skin and internal organs. SSc is a severe disease in which fibrotic events lead to organ failure such as renal failure, deterioration of lung function and development of pulmonary arterial hypertension (PAH). Together, these disease hallmarks culminate in profound disability and premature death.Over the past three years several crucial observations by my group changed the",{"id":695,"funder":7,"programme":8,"title":696,"piName":14,"institution":687,"country":28,"year":13,"amount":697,"abstract":698},"cordis-european-research-council-award-282012","Sensory Integration in the Striatal Microcircuit","€1,494,445","Motor behaviour requires the meaningful integration of a multitude of sensory information. The basal ganglia are essential for such sensory-motor processing and underlie motor planning, performance, and learning. The striatum is the input layer of the basal ganglia, acting as a “hub” that receives synaptic inputs from different brain regions, interacting primarily with the GABAergic striatal microcircuit. Sensory excitatory inputs to striatum arise from the thalamus and neocortex, targeting stri",{"id":700,"funder":7,"programme":8,"title":701,"piName":14,"institution":702,"country":12,"year":13,"amount":703,"abstract":704},"cordis-european-research-council-award-307442","Tailoring Material Properties Using Femtosecond Lasers: A New Paradigm for Highly Integrated Micro-\u002FNano- Scale Systems","ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE","€1,757,396","Using recent progress in laser technology and in particular in the field of ultra-fast lasers, we are getting close to accomplish the alchemist dream of transforming materials. Compact lasers can generate pulses with ultra-high peak powers in the Tera-Watt or even Peta-Watt ranges. These high-power pulses lead to a radically different laser-matter interaction than the one obtained with conventional lasers. Non-linear multi-photons processes are observed; they open new and exciting opportunities ",{"id":706,"funder":7,"programme":8,"title":707,"piName":14,"institution":708,"country":39,"year":13,"amount":709,"abstract":710},"cordis-european-research-council-award-307311","Integrating Graphene Devices","UNIVERSITAET SIEGEN","€1,498,687","Technology requirements for future IC systems include low power computing and communication, sensing capabilities and energy harvesting. These will unlikely be met with silicon technology alone. The proposed research therefore investigates graphene as a potential alternative technology and contributes to bridging the “valley of death” in innovation that is all too present in Europe. In detail, the proposal focuses on the experimental exploration of novel (opto-) electronic devices and systems ba",{"id":712,"funder":7,"programme":8,"title":713,"piName":14,"institution":714,"country":57,"year":13,"amount":715,"abstract":716},"cordis-european-research-council-award-280255","Engineering protein switches: sensors and regulators for biology and diagnostics","TECHNISCHE UNIVERSITEIT EINDHOVEN","€1,999,883","Proteins that switch between distinct conformational states are ideal to monitor and control molecular processes within the complexity of living cells. Inspired by the modular design of natural signaling proteins, we are pursuing a true engineering approach towards the development of protein switches which we call ‘plug-and-play’ protein engineering. In this approach we explore generic strategies to translate molecular recognition in an input protein domain directly into a readable signal genera",{"id":718,"funder":7,"programme":8,"title":719,"piName":14,"institution":687,"country":28,"year":13,"amount":14,"abstract":720},"cordis-european-research-council-award-284366","Emotional Learning in Social Interaction","This project will open up new horizons in the study of emotional learning by describing and modeling its role in social interaction. It brings together a novel set of experimental manipulations with two hitherto unconnected lines of research; biology of aversive learning and social cognition, with the aim to answer four specific objectives, namely to identify the mechanisms of aversive learning (1) about others and its dependence on stimulus bound (e.g. ethnic group belonging) and conceptual (e.",{"id":722,"funder":7,"programme":8,"title":723,"piName":14,"institution":681,"country":39,"year":13,"amount":724,"abstract":725},"cordis-european-research-council-award-281719","Receptor signalling mediating malaria parasite motility","€1,453,800","Plasmodium sporozoites are the motile forms of the malaria parasite injected into the host by a mosquito. Sporozoite motility is essential for tissue penetration as well as host cell invasion and thus pathogenesis suggesting that blocking motility could potentially add a new way in controlling malaria. It is dependent on a parasite specific myosin, a highly divergent actin and plasma membrane proteins, adhesins that link the substrate to the actomyosin motor. We want to understand the molecular ",{"id":727,"funder":7,"programme":8,"title":728,"piName":14,"institution":702,"country":12,"year":13,"amount":729,"abstract":730},"cordis-european-research-council-award-279735","Theoretical and Algorithmic Foundations for Future Proof Information and Inference Systems","€1,824,220","A critical technological challenge for emerging information systems is to acquire, analyze and learn from the ever-increasing high-dimensional data produced by natural and man-made phenomena. Sampling, streaming, and recoding of even the most basic applications now produce a data deluge that severely stresses the available analog-to-digital converter, digital communication and storage resources, and easily swamps the back-end processing and learning systems.Surprisingly, while the ambient data d",{"id":732,"funder":7,"programme":8,"title":733,"piName":14,"institution":702,"country":12,"year":13,"amount":734,"abstract":735},"cordis-european-research-council-award-278656","Toward Zero-Defect Software Through Automatic Cooperative Self-Improvement","€1,334,977","This proposal advocates a fundamentally new approach to achieving software quality: remove the distinction between software use and software testing -- enable programs to accumulate experience from each one of their executions, and leverage this experience toward self-improvement of the software. My hypothesis is that every program execution has information by-products that, if suitably captured and aggregated, can substantially speed up the process of testing programs and proving them correct. ",{"id":737,"funder":7,"programme":8,"title":738,"piName":14,"institution":702,"country":12,"year":13,"amount":14,"abstract":739},"cordis-european-research-council-award-307338","Nanowire Atomic Force Microscopy for Real Time Imaging of Nanoscale Biological Processes.","Short summary:The ability to measure structures with nanoscale resolution continues to transform physics, materials science and life science alike. Nevertheless,  while there are excellent tools to obtain detailed molecular-level static structure (for example in biology), there are very few tools to develop an understanding of how these structures change dynamically as they fulfill their biological function. New biologically-compatible, high-speed nanoscale characterization technologies are requ",{"id":741,"funder":7,"programme":8,"title":742,"piName":14,"institution":199,"country":21,"year":13,"amount":14,"abstract":743},"cordis-european-research-council-award-278004","Freezing Colloids","The freezing of colloids is an amazingly common phenomenon encountered in many natural and engineering processes such as the freezing of soils, food engineering or cryobiology. It can also be used as a bioinspired, versatile and environmentally-friendly processing route for bioinspired porous materials and composites exhibiting breakthroughs in functional properties. Yet, it is still a puzzling phenomenon with many unexplained features, due to the complexity of the system, the space and time sca",{"id":745,"funder":7,"programme":8,"title":746,"piName":14,"institution":702,"country":12,"year":13,"amount":14,"abstract":747},"cordis-european-research-council-award-279804","Foundations of Algebraic and Dynamic Data Management Systems","Contemporary database query languages are ultimately founded on logic and feature an additive operation – usually a form of (multi)set union or disjunction – that is asymmetric in that additions or updates do not always have an inverse. This asymmetry puts a greater part of the machinery of abstract algebra for equation solving outside the reach of databases. However, such equation solving would be a key functionality that problems such as query equivalence testing and data integration could be ",{"id":749,"funder":7,"programme":8,"title":750,"piName":14,"institution":199,"country":21,"year":13,"amount":751,"abstract":752},"cordis-european-research-council-award-281590","DNA traffic during bacterial cell division","€1,565,938","The molecular mechanisms that serve to couple DNA replication, chromosome segregation and cell division are largely unknown in bacteria. This led a considerable interest to the study of Escherichia coli FtsK, an essential cell division protein that assembles into DNA-pumps to transfer chromosomal DNA between the two daughter cell compartments during septation. Indeed, our recent work suggests that FtsK might regulate the late stages of septation to ensure DNA is fully cleared from the septum bef",{"id":754,"funder":7,"programme":8,"title":755,"piName":14,"institution":756,"country":28,"year":13,"amount":757,"abstract":758},"cordis-european-research-council-award-279611","Understanding the Hardness of Theorem Proving","KUNGLIGA TEKNISKA HOEGSKOLAN","€1,460,000","This project aims to explore the fundamental question in computer science and mathematics regarding what computational problems can feasibly be solved on a computer. More specifically, we want to study algorithms for proving logic formulas as well as impossibility results for this problem.Proving formulas in propositional logic is a problem of immense importance both theoretically and practically. On the one hand, this computational task is believed to be intractable in general, and deciding whe",{"id":760,"funder":7,"programme":8,"title":761,"piName":14,"institution":756,"country":28,"year":13,"amount":762,"abstract":763},"cordis-european-research-council-award-279933","Flexible object manipulation based on statistical learning and topological representations","€1,398,720","A vision for the future are autonomous and semi-autonomous systems that perform complex tasks safely and robustly in interaction with humans and the environment.  The action of such a system needs to be carefully planned and executed, taking into account the available sensory feedback and knowledge about the environment. Many of the existing approaches view motion planning as a geometrical problem, not taking the uncertainty into account.  Our goal is to study how different type of representatio",{"id":765,"funder":7,"programme":8,"title":766,"piName":14,"institution":767,"country":12,"year":13,"amount":768,"abstract":769},"cordis-european-research-council-award-279599","Investigating Functional Dynamics in Proteins by Novel Multidimensional Optical Spectroscopies in the Ultraviolet","UNIVERSITAET BERN","€1,473,600","Proteins perform their biological function following specific sequences of events. During these dynamical paths, highly non-trivial cooperative interactions occur. Ultimately, this is the origin of the emerging collective behavior that makes proteins the most sophisticated existing molecular machines. This complex network of processes covers a wide range of timescales, from few fs to ms, and distances, from atoms to large protein domains.Even the most recent experimental techniques generally pro",{"id":771,"funder":7,"programme":8,"title":772,"piName":14,"institution":714,"country":57,"year":13,"amount":773,"abstract":774},"cordis-european-research-council-award-280209","Prostate cancer localization by contrast-ultrasound angiogenesis imaging","€1,430,955","Prostate cancer causes over 1\u002F4 of new cancer cases and 1\u002F10 of cancer deaths in western males. Efficient methods for early treatment are available. Many lives could therefore be saved by early cancer detection, but this is not viable due to the inadequacy of the available noninvasive diagnostics. Systematic biopsy is the only reliable detection technique, but it is hampered by high costs and causes serious discomfort and health risks because of its invasiveness. Moreover, precise cancer localiz",{"id":776,"funder":7,"programme":8,"title":777,"piName":14,"institution":778,"country":507,"year":13,"amount":779,"abstract":780},"cordis-european-research-council-award-278912","Silicon nanocrystals coated by photoactive molecules: a new class of organic-inorganic hybrid materials for solar energy conversion","ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA","€1,182,606","Silicon nanocrystals (SiNCs) have gained much attention in the last few years because of their remarkable optical and electronic properties, compared to bulk silicon. These unique properties are due to quantum confinement effects and are thus strongly dependent on the nanocrystal size, shape, surface functionalization and presence of defects.The aim of the present project is the coupling of SiNCs with photo- and electroactive molecules or multicomponent systems, like dendrons, to build up a new ",{"id":782,"funder":7,"programme":8,"title":783,"piName":14,"institution":784,"country":57,"year":13,"amount":785,"abstract":786},"cordis-european-research-council-award-281474","Human leukemic stem cells: from identification towards targeting and eradication","ACADEMISCH ZIEKENHUIS GRONINGEN","€1,499,820","Human myeloid leukemias are life-threatening disorders. Although with current therapies the bulk of the tumor is readily eradicated, it is particularly the rare population of leukemic stem cells (LSCs) that is relatively quiescent and is very difficult to target. As a consequence, relapse of the disease occurs frequently resulting in poor survival rates. Nevertheless, remarkable differences do exist between subsets of patients. It is important to realize that leukemias are rather heterogeneous d",{"id":788,"funder":7,"programme":8,"title":789,"piName":14,"institution":784,"country":57,"year":13,"amount":790,"abstract":791},"cordis-european-research-council-award-310765","Harvesting the power of a new model organism: stem cells, regeneration and ageing in Macrostomum lignano","€1,499,723","The ‘stem-cell theory’ of ageing posits that the functional decline in adult stem cells is one of the factors contributing to ageing. Importantly, the number of stem cells does not diminish with age in many tissues but rather there are intrinsic and extrinsic changes that affect their functionality. Is it possible to reverse these changes? Experiments in the emerging model Macrostomum lignano suggest that this is indeed the case. Remarkably, induced regeneration in this animal leads to extended ",{"id":793,"funder":7,"programme":8,"title":794,"piName":14,"institution":795,"country":380,"year":13,"amount":796,"abstract":797},"cordis-european-research-council-award-281760","Health consequences of noise exposure from road traffic","KRAEFTENS BEKAEMPELSE","€1,334,890","There is growing public concern about adverse effects of traffic noise on health, as research has found that traffic noise increases the risk for cardiovascular diseases. Noise is thought to act as a stressor and disturbs sleep. Though this potentially could increase the risk for other major diseases, noise effects on other than the cardiovascular diseases are virtually unexplored.The main objective of this project is to investigate if long-term exposure to road traffic noise is detrimental to v",{"id":799,"funder":7,"programme":8,"title":800,"piName":14,"institution":670,"country":380,"year":13,"amount":801,"abstract":802},"cordis-european-research-council-award-307447","Long Beamtime Experiments for Nuclear Astrophysics","€1,476,075","The goal of LOBENA is to measure key properties needed for understanding nuclear processes in the Cosmos. Nuclear Astrophysics plays a key role in our quest to understand the origin and distribution of the chemical elements in our galaxy. Nuclear processes are crucial for understanding the energy production in the universe and are essential for describing the creation of chemical elements from the ashes of the Big Bang. Uncertainties in the nuclear physics can therefore influence our understandi",{"id":804,"funder":7,"programme":8,"title":805,"piName":14,"institution":806,"country":57,"year":13,"amount":807,"abstract":808},"cordis-european-research-council-award-306890","Hybrid imaging agents for the illumination of peripheral nerve structures","ACADEMISCH ZIEKENHUIS LEIDEN","€1,498,800","The aim of the ILLUMINATING NERVES project is to develop and synthesize new imaging agents that eventually can be used for surgical guidance around delicate nerve structures. The applicants research group already has made a major contribution to the clinical field of surgical guidance by introducing a concept wherein a multimodal\u002Fhybrid, imaging agent is used to provide fully integrated preoperative 3D imaging, surgical procedure planning, and real-time surgical fluorescence guidance. Illuminati",{"id":810,"funder":7,"programme":8,"title":811,"piName":14,"institution":812,"country":813,"year":13,"amount":814,"abstract":815},"cordis-european-research-council-award-279578","Towards real time multiscale simulation of cutting in non-linear materials with applications to surgical simulation and computer guided surgery","UNIVERSITE DU LUXEMBOURG","LU","€1,343,955","Surgeons are trained as apprentices. Some conditions are rarely encountered and surgeons will only be trained in the specific skills associated with a given situation if they come across it. At the end of their residency, it is hoped that they will have faced sufficiently many cases to be competent. This can be dangerous to the patients.If we were able to reproduce faithfully, in a virtual environment, the audio, visual and haptic experience of a surgeon as they prod, pull and incise tissue, the",{"id":817,"funder":7,"programme":8,"title":818,"piName":14,"institution":649,"country":110,"year":13,"amount":14,"abstract":819},"cordis-european-research-council-award-281961","Molecular Studies of Astrocyte Function in Health and Disease","Brain consists of two basic cell types – neurons and glia. However, the study of glia in brain function has traditionally been neglected in favor of their more “illustrious” counter-parts – neurons that are classed as the computational units of the brain. Glia have usually been classed as “brain glue” - a supportive matrix on which neurons grow and function. However, recent evidence suggests that glia are more than passive “glue” and actually modulate neuronal function. This has lead to the prop",{"id":821,"funder":7,"programme":8,"title":822,"piName":14,"institution":649,"country":110,"year":13,"amount":14,"abstract":823},"cordis-european-research-council-award-308459","Oxygen sensing in macrophages: implications for cancer and ischemia","Macrophages exist in distinct differentiation states. Proangiogenic\u002Fimmunosuppressive (M2-like) macrophages and antitumoral\u002Fproinflammatory (M1-like) macrophages represent two extremities of a continuum. Because lineage-defined subsets have not been identified yet, macrophage heterogeneity is likely to reflect the plasticity of these cells in response to microenvironmental signals. The concept that hypoxia can induce inflammation has gained general acceptance. However, little is known on how ext",{"id":825,"funder":7,"programme":8,"title":826,"piName":14,"institution":649,"country":110,"year":13,"amount":827,"abstract":828},"cordis-european-research-council-award-311719","Reverse engineering of vascular patterning through mosaic in vivo analysis of endothelial cell shape regulation","€1,373,503","Current angiogenesis research using genetic loss-of function approaches in mouse and zebrafish models provides for a growing number of genes implicated in blood vessel formation. Mechanistic insight often remains unsatisfactory as phenotypes fall into common categories. Our recent cell competition models combined with computational analysis have transformed the way we can study mechanisms in vascular patterning.I propose to systematically exploit mosaic analysis in vivo to deconstruct vascular p",{"id":830,"funder":7,"programme":8,"title":831,"piName":14,"institution":832,"country":86,"year":13,"amount":51,"abstract":833},"cordis-european-research-council-award-282300","POLARITY AND SUBCELLULAR DYNAMICS IN PLANTS","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","Plant life strategy is marked by acquisition of highly flexible development that adapts plants’ phenotype to the environment. Various environmental signals are integrated into the endogenous signalling networks involving the versatile phytohormone auxin. The intercellular auxin transport mediates a large variety of adaptive plant growth responses. Subcellular polar distribution of PIN auxin transporters determines directionality of auxin flow and thus have potential to integrate internal and ext",{"id":835,"funder":7,"programme":8,"title":836,"piName":14,"institution":837,"country":584,"year":13,"amount":838,"abstract":839},"cordis-european-research-council-award-281191","Variability in the mutation rate of RNA viruses","UNIVERSITAT DE VALENCIA","€1,432,021","RNA viruses are the fastest evolving entities in nature. Such rapid evolution is explained by their mutation rates, which are orders of magnitude higher than those of DNA organisms. The error-prone replication of RNA viruses also has public-health implications related to pathogenesis, antiviral research, or viral emergence. However, current mutation rate estimates vary by more than 100-fold across different RNA viruses and sometimes over one order of magnitude for the same virus, and the causes ",{"id":841,"funder":7,"programme":8,"title":842,"piName":14,"institution":199,"country":21,"year":13,"amount":843,"abstract":844},"cordis-european-research-council-award-307370","Hybrid Quantum Nano-Optomechanics","€1,792,140","The chief endeavor of the project is to develop, investigate and exploit systems associating nanoscale mechanical resonators with single quantum objects. Such combinations belong in the category of so-called “hybrid nanomechanical systems” which constitutes a rapidly expanding field in modern quantum- and nanophysics.The benefit of exploring hybrid systems is manifold. From a practical point of view, due to their size, nanoresonators are extremely sensitive to external forces.  If associated wit",{"id":846,"funder":7,"programme":8,"title":847,"piName":14,"institution":199,"country":21,"year":13,"amount":848,"abstract":849},"cordis-european-research-council-award-306845","Statistical physics of dense particle systems in the absence of thermal fluctuations","€1,339,800","Frontier research in statistical mechanics and soft condensed matter focuses on systems of ever-increasing complexity. Among these are systems where microscopic dynamics are not controlled by thermal fluctuations, either because the sources of the fluctuations have not a thermal origin, or because “microscopic” sources of fluctuations are altogether absent. Practical applications comprise everyday products such as paints or foodstuff which are soft solids composed of dense suspensions of particl",{"id":851,"funder":7,"programme":8,"title":852,"piName":14,"institution":199,"country":21,"year":13,"amount":853,"abstract":854},"cordis-european-research-council-award-277762","UltraCOLD ion and electron beams for NANOscience","€1,944,000","COLDNANO (UltraCOLD ion and electron beams for NANOscience), aspires to build novel ion and electron sources with superior performance in terms of brightness, energy spread and minimum achievable spot size. Such monochromatic, spatially focused and well controlled electron and ion beams are expected to open many research possibilities in material sciences, in surface investigations (imaging, lithography) and in semiconductor diagnostics. The proposed project intends to develop sources with the b",{"id":856,"funder":7,"programme":8,"title":857,"piName":14,"institution":858,"country":39,"year":13,"amount":859,"abstract":860},"cordis-european-research-council-award-306298","Enhancing and Tuning Electroluminescence with Nanoantennas","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","€1,496,684","Being able to enhance and tune the interaction of a light wave with a molecule or nanoparticle on a fundamental level opens up an exciting range of applications such as more efficient solar cells, more sensitive photon detectors and brighter emitters for lighting applications. Nanoplasmonics promises to offer this level of control. Taking the current knowledge on nanoantennas a step further we will integrate them in organic and carbon-nanotube light-emitting devices to improve and tune their emi",{"id":862,"funder":7,"programme":8,"title":863,"piName":14,"institution":199,"country":21,"year":13,"amount":864,"abstract":865},"cordis-european-research-council-award-283870","Territories, Communities and Exchanges in the Sino-Tibetan Kham Borderlands (China)","€651,722","This research project will focus on the area of the Sino-Tibetan borderlands situated within the People’s Republic of China, and referred to as Kham by Tibetans who make up most of the population of this region divided between the provinces of Sichuan to the east, Yunnan to the south and the Tibet Autonomous Region to the west. This research project intends to explore from a comparative perspective the possible definitions of this entity called Kham, which in the course of history has never stri",{"id":867,"funder":7,"programme":8,"title":868,"piName":14,"institution":199,"country":21,"year":13,"amount":869,"abstract":870},"cordis-european-research-council-award-279519","Two-Field Nuclear Magnetic Resonance Spectroscopy for the Exploration of Biomolecular Dynamics","€1,462,080","The paradigm of the structure-function relationship in proteins is outdated. Biological macromolecules and supramolecular assemblies are highly dynamic objects. Evidence that their motions are of utmost importance to their functions is regularly identified. The understanding of the physical chemistry of biological processes at an atomic level has to rely not only on the description of structure but also on the characterization of molecular motions.The investigation of protein motions will be und",{"id":872,"funder":7,"programme":8,"title":873,"piName":14,"institution":611,"country":57,"year":13,"amount":874,"abstract":875},"cordis-european-research-council-award-309555","Systems biology meets evolutionary theory: modeling the genetics and adaptation of complex traits","€1,452,478","As we learn more about the mechanisms of development, it remains a challenge to understand the relationship between molecular processes and functional characteristics of the organism. The complexity of the networks that link genes and phenotypes is nearly ignored by evolutionary theory, which builds on simple phenomenological models of the genotype-phenotype relationship. These models treat development as a black box, leaving mainstream evolutionary theory ill-equipped to explain how molecular m",{"id":877,"funder":7,"programme":8,"title":878,"piName":14,"institution":199,"country":21,"year":13,"amount":14,"abstract":879},"cordis-european-research-council-award-311403","Glia, Smell, Food & Courtship in Drosophila","Odors are key components for sensory communication involved in behaviors such as social communication or food search. Recently, molecular receptors, neuronal architecture, physiological regulation, and behavioral consequences underlying these biological processes are starting to be revealed in an increasing number of animal models. But more and more breakthroughs are highlighting some unexpected results asking for deeper studies. The Drosophila melanogaster has proven to be a particular powerful",{"id":881,"funder":7,"programme":8,"title":882,"piName":14,"institution":199,"country":21,"year":13,"amount":14,"abstract":883},"cordis-european-research-council-award-307280","Self-organisation at two length-scales: generation and characterisation of porous materials with chemically and physically modified surfaces","Surfaces play a crucial role in the interaction of a material with its environment. Recent advances in Soft Matter physics reveal the extraordinary properties of surfaces with complex physico-chemical modifications. Of particular interest is the influence of such modifications on the wetting and flow of simple or complex fluids. Despite growing research efforts, a sound understanding and large-scale applications remain out of reach due to the difficulty of creating complex surfaces with satisfyi",{"id":885,"funder":7,"programme":8,"title":886,"piName":14,"institution":199,"country":21,"year":13,"amount":887,"abstract":888},"cordis-european-research-council-award-282046","Disarming bacterial weapons in the nucleus: functional study of Chlamydia nuclear effectors","€1,491,660","The high prevalence of Chlamydia infections and the heavy burden they inflict on public health justify the search for novel therapeutic approaches directed against this pathogen. Research on this obligate intracellular bacterium is very difficult, due to substantial technical impediments. One current challenge is to identify bacterial proteins that are required for Chlamydia to survive and proliferate in the host and that could serve as targets in novel therapeutic strategies. In particular, the",{"id":890,"funder":7,"programme":8,"title":891,"piName":14,"institution":595,"country":110,"year":13,"amount":892,"abstract":893},"cordis-european-research-council-award-284025","UNDERSTANDING THE NATURE OF FACE PERCEPTION: NEW INSIGHTS FROM STEADY-STATE VISUAL EVOKED POTENTIALS","€1,490,360","Face recognition is one of the most complex functions of the human mind\u002Fbrain, so that no artificial device can surpass human abilities in this function. The goal of this project is to understand a fundamental aspect of face recognition, individual face perception: how, from sensory information, does the human mind\u002Fbrain build a visual representation of a particular face? To clarify this question, I will introduce the method of steady-state visual evoked potentials (SSVEPs) in the field of face ",{"id":895,"funder":7,"programme":8,"title":896,"piName":14,"institution":199,"country":21,"year":13,"amount":897,"abstract":898},"cordis-european-research-council-award-306658","Low-valent silicon complexes:Transition metal-like catalysts","€1,433,725","This project principally concerns the use of silicon (the second most abundant element in the Earth’s crust) as catalyst instead of transition metals. Although the importance of its abundance is well recognized in material chemistry, as it can be seen by the vast world production of silicon based materials (polymers, rubber, semiconductors), real success in chemistry with such a vision has never been achieved. This is probably due to the lack of appropriate stable silicon species with particular",{"id":900,"funder":7,"programme":8,"title":901,"piName":14,"institution":199,"country":21,"year":13,"amount":14,"abstract":902},"cordis-european-research-council-award-307856","From complex to non-archimedean geometry","Complex geometry is the study of manifolds that are defined over the complex numbers. Non-archimedean geometry is concerned with analytic spaces overfields endowed with a norm that satisfies the strong triangular inequality.The aim of this proposal is to explore the interactions between these seemingly different geometrieswith  special emphasis on analytic and dynamical problems.We specifically plan to develop pluripotential theory over non-archimedean fields. This includes the search  for analo",{"id":904,"funder":7,"programme":8,"title":905,"piName":14,"institution":199,"country":21,"year":13,"amount":14,"abstract":906},"cordis-european-research-council-award-281225","Harnessing systems immunology to unravel dendritic cell subset biology","The development of better vaccines against cancer or intracellular pathogens is a major challenge of immunological research. Novel approaches are needed to induce efficient, long-lasting memory CD8 T cell (CTL) responses. The CD8α subset of mouse dendritic cells (mDC) is specialized in this function, excelling at antigen cross-presentation. Their targeting in vivo for vaccination yielded encouraging results. How to translate this strategy for human health was not obvious, because no human DC (hD",{"id":908,"funder":7,"programme":8,"title":909,"piName":14,"institution":583,"country":584,"year":13,"amount":51,"abstract":910},"cordis-european-research-council-award-282329","Wiring up visual circuits: Interplay between gene expression and spontaneous and experience-dependent activity","A fundamental feature of the developing neural circuits is their ability to change in response to sensorial experience. This phenomenon has been particularly observed during the generation of cortical maps, where altering the pattern of sensory experience changes the spatial organization of sensory representations. The mechanisms underlying this form of plasticity include synaptic modification such as long-term potentiation and long-term depression, classically referred to as Hebbian-based rules",{"id":912,"funder":7,"programme":8,"title":913,"piName":14,"institution":914,"country":584,"year":13,"amount":915,"abstract":916},"cordis-european-research-council-award-306250","Innovative Polymers for Energy Storage","UNIVERSIDAD DEL PAIS VASCO\u002F EUSKAL HERRIKO UNIBERTSITATEA","€1,430,239","iPes project aims to provide adequate support to Dr. David Mecerreyes (DM) who is at the stage of consolidating an independent research team. During his scientific career, DM has demonstrated creative thinking and excellent capacity to carry out research and going beyond the state of the art. His meritorious record of research, scientific publications (128 ISI articles, h index = 33), project conception, private sector experience, networking ability (participated in 10 European collaborative pro",{"id":918,"funder":7,"programme":8,"title":919,"piName":14,"institution":199,"country":21,"year":13,"amount":920,"abstract":921},"cordis-european-research-council-award-278248","Microfluidic multiplexed cell chips","€1,494,744","There exist very few techniques for studying a group of cells containinga large number compared to a single cell but small compared to a wholetissue. This implies that statistics are exceedingly difficult to obtainfrom measurements of individual cells. Microfluidics provides a way toamend this by allowing ways to observe individual cells and automatesuch measurements. The aim in this project is to develop a cellmanipulation platforms based on microfluidics techniques developed inour lab, while a",{"id":923,"funder":7,"programme":8,"title":924,"piName":14,"institution":199,"country":21,"year":13,"amount":925,"abstract":926},"cordis-european-research-council-award-279977","Enzyme catalysis in organic solvents","€1,390,800","Enzymes are remarkably efficient catalysts and their recent use in non-aqueous organic solvents is opening a tremendous range of applications in synthetic chemistry: since, surprisingly, most enzymes do not denature in these non-natural environments, new reactions involving e.g. water-insoluble reagents can be catalyzed, while unwanted degradation side reactions are suppressed.However, a key challenge for these applications is to overcome the greatly reduced catalytic activity compared to aqueou",{"id":928,"funder":7,"programme":8,"title":929,"piName":14,"institution":535,"country":64,"year":13,"amount":930,"abstract":931},"cordis-european-research-council-award-280127","Probing fundamental physics with multi-wavelength cosmology","€1,424,269","Recent measurements of the Cosmic Microwave Background (CMB) combined with the large-scale distribution of galaxies have defined a standard cosmological model. This model is a remarkable fit to the observations but also raises profound questions - we do not know how the initial conditions were imprinted in the early Universe, nor do we know the nature of the dark energy. In this proposal, I request funds to set up a new cosmology data analysis team at the University of Manchester to tackle these",{"id":933,"funder":7,"programme":8,"title":934,"piName":14,"institution":473,"country":21,"year":13,"amount":935,"abstract":936},"cordis-european-research-council-award-281025","Differentiation and role of Natural Killer cell subsets","€1,340,757","NK cells are innate lymphocytes that play a role in the early response against intracellular pathogens and against tumors. Several NK cell subsets have been described in peripheral organs that correspond to discrete stages of in vivo maturation. How NK cells differentiate from early precursors and what are the specific functions of each NK cell subset are unresolved issues. Here, we propose a three-aim program to address these questions. First, we want to revisit the partition of the NK cell pop",{"id":938,"funder":7,"programme":8,"title":939,"piName":14,"institution":199,"country":21,"year":13,"amount":940,"abstract":941},"cordis-european-research-council-award-312514","International Grievance Mechanisms and International Law and Governance","€590,153","The paradigms and terms of global governance have raised considerable debates in social sciences, as this elusive notion reflects the complexification of the decision-making fora, actors and processes which address globalised issues. Primarily intended as the legal framework of inter-state relations, international law is deeply shaken up by global governance approaches. In particular, because of systemic regulation and justiciability gaps, it shows a relative inability to create the mechanisms n",{"id":943,"funder":7,"programme":8,"title":944,"piName":14,"institution":756,"country":28,"year":13,"amount":945,"abstract":946},"cordis-european-research-council-award-308267","Fluid Spectrum Acess","€1,197,040","Spectrum is a key and scarce resource in wireless communication networks, and it remains tightly controlled by regulation authorities. Most of the frequency bands are exclusively allocated to a single system licensed to use it everywhere and for long periods of time. This rigid spectrum management model inevitably leads to significant inefficiencies in spectrum use. The explosion of demand for broadband wireless services also calls for more flexible models where much larger spectrum parts could ",{"id":948,"funder":7,"programme":8,"title":949,"piName":14,"institution":540,"country":541,"year":13,"amount":950,"abstract":951},"cordis-european-research-council-award-283741","New Contexts for Old Texts: Unorthodox Texts and Monastic Manuscript Culture in Fourth- and Fifth-Century Egypt","€1,475,143","Using recently accessible Coptic monastic texts, new philology, and cognitive theories of literature and memory, this project aims to shed important new light on the production and use of some of the most enigmatic manuscripts discovered during the last century, namely the Nag Hammadi codices, together with the highly similar Berlin, Bruce, Askew, and Tchacos codices. This will be done by interpreting the contents of the codices as they are preserved to us in their Coptic versions primarily with",{"id":953,"funder":7,"programme":8,"title":954,"piName":14,"institution":955,"country":507,"year":13,"amount":956,"abstract":957},"cordis-european-research-council-award-280611","Role of the transcription factor Nfix in muscle regeneration and muscular dystrophies","UNIVERSITA DEGLI STUDI DI MILANO","€1,386,945","I will study the role of the transcription factor  Nfix, in post-natal skeletal muscle growth and regeneration, and in the pathogenesis of muscular dystrophies. I have recently demonstrated the role of the transcription factor Nuclear Factor IX, Nfix, in driving the transcriptional switch from embryonic to fetal myogenesis, characterized by a switch from slow to fast twitching and more mature fibers. Current data show that Nfix is also strongly expressed in satellite cells (SCs), the muscle adul",{"id":959,"funder":7,"programme":8,"title":960,"piName":14,"institution":199,"country":21,"year":13,"amount":961,"abstract":962},"cordis-european-research-council-award-281422","Toward Eco-Evolutionary Models for BIODiversity Scenarios","€1,482,705","Given the contemporary biodiversity crisis, effective conservation strategies that offset the threats to ecosystem integrity are crucial for maintaining biodiversity. The development of sound biodiversity scenarios is thus a major challenge for the scientific community. However, current biodiversity models rarely incorporate recent advances in ecological and evolutionary theory like: (i) how evolution shapes species’ niches and ranges; (ii) how community assembly rules shape species' ranges; and",{"id":964,"funder":7,"programme":8,"title":965,"piName":14,"institution":199,"country":21,"year":13,"amount":966,"abstract":967},"cordis-european-research-council-award-281359","Systems Genetics of Heritable variaTions","€1,499,660","The complexity by which genotypes modulate phenotypic variation has been a major obstacle in understanding the basis of inter-individual differences. In the particular case of disease susceptibility, enormous efforts have been conducted among large consortia of quantitative geneticists, and a recent wealth of results showed both victories and frustrations. Victories because many genetic factors could successfully be linked to diabetes, heart failure, cancer, infectivity, and many other common di",{"id":969,"funder":7,"programme":8,"title":970,"piName":14,"institution":524,"country":507,"year":13,"amount":971,"abstract":972},"cordis-european-research-council-award-307032","Quantum simulation of two-dimensional fermionic systems","€1,243,200","Two-dimensional fermionic systems show remarkable physical properties, not only of interest for fundamental science but also directed towards technological application. Two paradigmatic examples are layered high-Tc superconductors and graphene. However, despite of decades of investigations, their theoretical comprehension is far from being complete.In QuFerm2D, I propose to use atomic Fermi gases to study the physics of two-dimensional strongly correlated fermions. Indeed, ultracold atoms are “i",{"id":974,"funder":7,"programme":8,"title":975,"piName":14,"institution":199,"country":21,"year":13,"amount":976,"abstract":977},"cordis-european-research-council-award-279954","Exploring Dark Energy through Cosmic Structures: Observational Consequences of Dark Energy Clustering","€1,468,800","Understanding the nature of Dark Energy (DE) in the Universe is the central challenge of modern cosmology. Einstein’s Cosmological Constant (Λ) provides the simplest explanation fitting the available cosmological data thus far. However, its unnaturally tuned value indicates that other hypothesis must be explored. Furthermore, current observations do not by any means rule out alternative models in favor of the simplest “concordance” ΛCDM. In the absence of theoretical prejudice, observational tes",{"id":979,"funder":7,"programme":8,"title":980,"piName":14,"institution":981,"country":64,"year":13,"amount":982,"abstract":983},"cordis-european-research-council-award-282051","How force regulates cell function: a molecular and cellular outlook","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€1,998,331","Force is ubiquitous in nature and physical stimuli are crucial for cell function. How cells process forces determines key physiological processes such as cell growth and differentiation, in which cells divide or differentiate according to the chemical and physical cues cells receive from the extracellular matrix. Physical stimuli have also been involved in the development of pathological processes, especially those in which cells lose the proper physical communication with the environment, such ",{"id":985,"funder":7,"programme":8,"title":986,"piName":14,"institution":987,"country":507,"year":13,"amount":988,"abstract":989},"cordis-european-research-council-award-283955","The impact of DEmographic Changes on Infectious DisEases transmission and control in middle\u002Flow income countries","UNIVERSITA COMMERCIALE LUIGI BOCCONI","€1,210,000","Population structure and change and social contact patterns are major determinants of the observed epidemiology of infectious diseases, including the consequences on health. Demographic structure and the components of demographic dynamics are changing over time and substantially differ within countries and most critically between countries. However, some of the overall consequences of demographic changes remain unclear, though urbanisation and fertility decline will certainly have a profound imp",{"id":991,"funder":7,"programme":8,"title":992,"piName":14,"institution":993,"country":64,"year":13,"amount":14,"abstract":994},"cordis-european-research-council-award-307636","Scandium-based multifunctional nitrides for optoelectronic, polaritonic and ferro\u002Fmagnetoelectric devices","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","Device performance is ultimately limited by material properties. To break existing performance limits, I plan to develop a new multifunctional Sc-based nitride materials platform in which tuneable semiconducting, ferroelectric and magnetic functionalities may be achieved for the first time. I can then address three major challenges: (1) solving a 20-year-old problem in solid-state-lighting using highly efficient green light-emitters, (2) creating the first electrically pumped full-spectrum polar",{"id":996,"funder":7,"programme":8,"title":997,"piName":14,"institution":981,"country":64,"year":13,"amount":998,"abstract":999},"cordis-european-research-council-award-306326","Automorphic Forms and Moduli Spaces of Galois Representations","€1,131,339","I propose to establish a research group to develop completely new tools in order to solve three important problems on the relationships between automorphic forms and Galois representations, which lie at the heart of the Langlands program. The first is to prove Serre’s conjecture for real quadratic fields. I will use automorphic induction to transfer the problem to U(4) over the rational numbers, where I will use automorphy lifting theorems and results on the weight part of Serre's conjecture tha",{"id":1001,"funder":7,"programme":8,"title":1002,"piName":14,"institution":1003,"country":39,"year":13,"amount":1004,"abstract":1005},"cordis-european-research-council-award-283503","Paleoanthropology at the Gates of Europe: Human Evolution in the Southern Balkans","EBERHARD KARLS UNIVERSITAET TUEBINGEN","€1,288,200","Despite long study, European paleoanthropology is still hotly debated and continues to produce unexpected and surprising findings. Such discoveries have radically changed our ideas about human presence in Europe: The former view of Europe as inhospitable to humans until 500 thousand years before present (ka) is now challenged by new evidence indicating colonization at just over one million years ago. Although these discoveries represent breakthroughs in European paleoanthropology, many questions",{"id":1007,"funder":7,"programme":8,"title":1008,"piName":14,"institution":981,"country":64,"year":13,"amount":561,"abstract":1009},"cordis-european-research-council-award-278940","Positive Scalar Curvature and Lagrangian Mean Curvature Flow","The interplay between Geometry and Analysis has been among the most fruitful mathematical ideas in recent years, the most obvious example being Perelman's proof of Poincare' conjecture. The goal of this proposal is to establish a research group that will make significant  progress in the following two distinct problems.Scalar Curvature: A classical theorem in Riemannian Geometry states that nonnegative scalar curvature metrics which are flat outside a compact set must be Euclidean. The equivalen",{"id":1011,"funder":7,"programme":8,"title":1012,"piName":14,"institution":981,"country":64,"year":13,"amount":1013,"abstract":1014},"cordis-european-research-council-award-280492","Physical principles in host-pathogen interactions","€1,343,230","In recent breakthrough publications, I developed quantitative models of accurate chemo-sensing in biological cells, as well as obtained important insights into how cells engulf and eat other cells and particles. The novelty of these works is the merging of the natural sciences of physics and biology for discovering general, overarching principles in biology. Now I propose to bring my research to a new level by tackling host-pathogen interactions, irrespective of established disciplinary boundari",{"id":1016,"funder":7,"programme":8,"title":1017,"piName":14,"institution":1018,"country":39,"year":13,"amount":1019,"abstract":1020},"cordis-european-research-council-award-307535","Sustainable Catalytic C-H Bond Functionalization","GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS","€1,499,338","The impressive progress in synthetic organic chemistry during the past century has propelled this discipline to its current central place as the key enabling technology in the physical and life sciences. Despite these remarkable advances, our ability to construct molecules of even moderate structural complexity remains unsatisfactory, since these syntheses continue to be inefficient, rely on a high number of reaction steps, and generate undesired, often toxic waste. These features led to the gen",{"id":1022,"funder":7,"programme":8,"title":1023,"piName":14,"institution":1018,"country":39,"year":13,"amount":1024,"abstract":1025},"cordis-european-research-council-award-279347","Development of new wavelength standards for the searchfor habitable planets","€1,437,200","The search for extrasolar planets is moving into the domain of Earth-like, habitable planets with more precise measurement techniques and a focus on low-mass, very cool stars. New spectrographs are being developed with the goal to find Earth-like planets in the habitable zones of stars other than the Sun. Extensive photometric programs, both ground- and space-based are running and being planned to discover transiting planets particularly useful for detailed investigation of exo-planetary atmosph",{"id":1027,"funder":7,"programme":8,"title":1028,"piName":14,"institution":1003,"country":39,"year":13,"amount":1029,"abstract":1030},"cordis-european-research-council-award-282122","Optogenetic examination of the role of feedback on visual processing and perception","€1,903,114","We need to understand the brain mechanisms of perception and cognition in order to develop treatments for disorders in which these abilities fail, such as schizophrenia, attention-deficit-hyperactivity disorder or autism. Over the past half-century neurophysiologists have enormously advanced our knowledge of how the feed-forward connections give rise to the response properties in the visual cortex. However, although we know from anatomy that most afferents in cortex constitute feedback projectio",{"id":1032,"funder":7,"programme":8,"title":1033,"piName":14,"institution":1034,"country":64,"year":13,"amount":1035,"abstract":1036},"cordis-european-research-council-award-283959","Primate archaeology: an evolutionary context for the emergence of technology","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€1,454,310","Technology is essential to human survival, prompting the fundamental question of why we are the only species ever to have evolved complete reliance on tool use. The Primate Archaeology project examines the evolution of tool use for three wild non-human primate species - chimpanzees (Pan troglodytes), bearded capuchins (Cebus libidinosus), and long-tailed macaques (Macaca fascicularis aurea) - in order to place the extraordinary degree of tool use seen in the human lineage into a multi-species co",{"id":1038,"funder":7,"programme":8,"title":1039,"piName":14,"institution":1034,"country":64,"year":13,"amount":1040,"abstract":1041},"cordis-european-research-council-award-306260","Dualities in Super-symmetric Gauge Theories, String Theory and Conformal Field Theories","€1,414,258","The aim of the present proposal is to establish a research team developing and exploiting dualities arising in super-symmetric gauge theories, string theory and conformal field theories.  These will also have many applications outside these fields. The overarching aims of the team will be: To develop established dualities into computational tools for physical quantities such as the S-matrix, correlation functions and partition functions. The construction of explicit examples of new dualities. To",{"id":1043,"funder":7,"programme":8,"title":1044,"piName":14,"institution":1034,"country":64,"year":13,"amount":1045,"abstract":1046},"cordis-european-research-council-award-281628","Neurocomputational determinants of decision urgency in humans","€1,182,176","A central question in the behavioural, cognitive and neural sciences is how humans choose between available alternatives (Does this patient have flu, or meningitis? Should I go on holiday to Spain, or Scotland?).  However, much less attention has been devoted to the question of when an agent should decide.  Longer deliberation is more likely to lead to better decisions (because it allows greater accumulation of decision-relevant evidence) but it also incurs a cost (because it delays reinforcemen",200,{"programme":8,"total":1049,"withPiName":1050,"firstYear":1051,"lastYear":1052,"countryCount":1053,"perYear":1054,"topInstitutions":1112,"topCountries":1181},7919,572,2008,2027,52,[1055,1057,1060,1063,1066,1068,1071,1074,1077,1080,1083,1086,1089,1092,1095,1098,1101,1104,1107,1110],{"year":1051,"count":1056},279,{"year":1058,"count":1059},2009,157,{"year":1061,"count":1062},2010,302,{"year":1064,"count":1065},2011,447,{"year":13,"count":1067},524,{"year":1069,"count":1070},2013,456,{"year":1072,"count":1073},2014,297,{"year":1075,"count":1076},2015,366,{"year":1078,"count":1079},2016,376,{"year":1081,"count":1082},2017,419,{"year":1084,"count":1085},2018,582,{"year":1087,"count":1088},2019,393,{"year":1090,"count":1091},2020,384,{"year":1093,"count":1094},2021,394,{"year":1096,"count":1097},2022,514,{"year":1099,"count":1100},2023,512,{"year":1102,"count":1103},2024,473,{"year":1105,"count":1106},2025,482,{"year":1108,"count":1109},2026,556,{"year":1052,"count":1111},6,[1113,1115,1118,1121,1123,1126,1129,1132,1135,1138,1141,1143,1146,1148,1151,1154,1157,1160,1162,1164,1167,1169,1172,1175,1178],{"name":1114,"count":1094},"Centre National de la Recherche Scientifique CNRS",{"name":1116,"count":1117},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",175,{"name":1119,"count":1120},"University of Cambridge",129,{"name":1122,"count":1120},"University of Oxford",{"name":1124,"count":1125},"Hebrew University of Jerusalem",112,{"name":1127,"count":1128},"University College London",110,{"name":1130,"count":1131},"Tel Aviv University",107,{"name":1133,"count":1134},"Weizmann Institute of Science",104,{"name":1136,"count":1137},"Eidgenoessische Technische Hochschule Zuerich",87,{"name":1139,"count":1140},"Kobenhavns Universitet",85,{"name":1142,"count":1140},"Universiteit Gent",{"name":1144,"count":1145},"Universiteit van Amsterdam",84,{"name":11,"count":1147},83,{"name":1149,"count":1150},"Ludwig-Maximilians-Universitaet Muenchen",82,{"name":1152,"count":1153},"Institut National de la Sante Et de la Recherche Medicale",78,{"name":1155,"count":1156},"Universiteit Utrecht",76,{"name":1158,"count":1159},"Imperial College of Science Technology and Medicine",71,{"name":1161,"count":1159},"Katholieke Universiteit Leuven",{"name":1163,"count":1159},"Technische Universiteit Delft",{"name":1165,"count":1166},"Technion - Israel Institute of Technology",70,{"name":1168,"count":1166},"Technische Universitaet Muenchen",{"name":1170,"count":1171},"Universiteit Leiden",69,{"name":1173,"count":1174},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",67,{"name":1176,"count":1177},"The University of Edinburgh",64,{"name":1179,"count":1180},"Helsingin Yliopisto",57,[1182,1184,1186,1188,1190,1191,1193,1195,1197,1199,1201,1203,1205,1207,1208,1210,1212,1215,1218,1220,1223,1226,1229,1232,1235],{"name":39,"count":1183},1346,{"name":64,"count":1185},1007,{"name":21,"count":1187},932,{"name":57,"count":1189},772,{"name":507,"count":1100},{"name":584,"count":1192},475,{"name":103,"count":1194},470,{"name":12,"count":1196},389,{"name":110,"count":1198},348,{"name":28,"count":1200},291,{"name":86,"count":1202},269,{"name":380,"count":1204},189,{"name":467,"count":1206},137,{"name":128,"count":1128},{"name":541,"count":1209},108,{"name":231,"count":1211},92,{"name":1213,"count":1214},"GB",68,{"name":1216,"count":1217},"PL",60,{"name":34,"count":1219},43,{"name":1221,"count":1222},"EL",41,{"name":1224,"count":1225},"US",36,{"name":1227,"count":1228},"HU",32,{"name":1230,"count":1231},"TR",24,{"name":1233,"count":1234},"SI",14,{"name":1236,"count":1237},"EE",10]