[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-starting-grant-2014":3,"awarded-stats-erc-starting-grant":1127},{"awarded":4,"total":1126},[5,16,23,29,36,41,48,55,61,68,74,80,87,93,99,105,112,118,124,130,136,143,150,155,160,167,171,177,184,190,196,203,208,214,220,225,230,236,242,248,253,258,260,266,272,278,284,287,292,298,304,310,316,321,326,331,337,343,348,354,359,365,370,376,382,388,393,395,401,406,412,418,423,428,433,438,444,450,457,462,468,474,479,485,490,495,502,508,513,517,523,528,534,539,543,549,554,560,565,570,576,583,588,594,599,605,611,617,623,628,634,640,646,653,658,663,669,674,680,686,692,698,704,709,714,720,726,731,736,742,748,754,760,766,772,779,785,789,794,798,803,809,814,820,826,831,837,842,848,854,861,867,872,878,882,887,892,898,903,908,914,920,925,929,935,941,946,951,956,960,964,969,975,980,985,990,996,1002,1008,1013,1019,1023,1029,1034,1040,1046,1052,1057,1062,1067,1072,1077,1082,1088,1094,1099,1104,1110,1115,1121],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-european-research-council-award-erc-2011-stg-282-413","European Research Council","ERC Starting Grant","Microvesicle‐associated microRNA expression is altered upon particulate matter exposure in healthy workers and in A549 cells","Valentina Bollati","University of Milan","IT",2014,null,"Cardiovascular disease risk has been consistently linked with particulate matter (PM) exposure. Cell-derived microvesicles (MVs) are released into plasma and transfer microRNAs (miRNAs) between tissues. MVs can be produced by the respiratory system in response to proinflammatory triggers, enter the circulatory system and remotely modify gene expression in cardiovascular tissues. However, whether PM affects MV signaling has never been investigated. In this study, we evaluated expression of microR",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":21,"year":13,"amount":14,"abstract":22},"openalex-european-research-council-award-erc-2011-stg-279363-hidgr-","Causality and hyperbolicity of Lovelock theories","Benson Way","University of Cambridge","GB","In Lovelock theories, gravity can travel faster or slower than light. The causal structure is determined by the characteristic hypersurfaces. We generalize a recent result of Izumi to prove that any Killing horizon is a characteristic hypersurface for all gravitational degrees of freedom of a Lovelock theory. Hence gravitational signals cannot escape from the region inside such a horizon. We investigate the hyperbolicity of Lovelock theories by determining the characteristic hypersurfaces for va",{"id":24,"funder":7,"programme":8,"title":25,"piName":26,"institution":27,"country":28,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2013-stg-337251","The Fire Within: Microbes Inflame Tumors","Richard A. Flavell","Howard Hughes Medical Institute","US",{"id":30,"funder":7,"programme":8,"title":31,"piName":32,"institution":33,"country":34,"year":13,"amount":14,"abstract":35},"openalex-european-research-council-award-erc-2010-stg-no-260242","Delivery by caesarean section and childhood cancer: a nationwide follow‐up study in three countries","NC Momen","Aarhus University","DK","OBJECTIVE: To investigate the association between delivery by caesarean section and risk of childhood cancer. DESIGN: A population-based, follow-up study using register data from three countries. SETTING: Denmark, Sweden and Finland. POPULATION: Children born in Denmark (1973-2007), Sweden (1973-2006) and Finland (randomly selected sample of 90%, 1987-2007; n = 7,029,843). METHODS: Exposure was delivery by caesarean section and the outcome was childhood cancer diagnosis. Follow-up started from b",{"id":37,"funder":7,"programme":8,"title":38,"piName":39,"institution":40,"country":12,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-stg-n-bnp-306406","Full Bayesian inference with hazard mixture models","Bernardo Nipoti","Collegio Carlo Alberto",{"id":42,"funder":7,"programme":8,"title":43,"piName":44,"institution":45,"country":46,"year":13,"amount":14,"abstract":47},"openalex-european-research-council-award-erc-2012-stg-306686","Optically anisotropic substrates via wrinkle-assisted convective assembly of gold nanorods on macroscopic areas","Andreas Fery","Institute of Physical Chemistry","PL","We demonstrate the large-scale organisation of anisotropic nanoparticles into linear assemblies displaying optical anisotropy on macroscopic areas. Monodisperse gold nanorods with a hydrophilic protein shell are arranged by dip-coating on wrinkled surfaces and subsequently transferred to indium tin oxide (ITO) substrates by capillary transfer printing. We elucidate how tuning the wrinkle amplitude enables us to precisely adjust the assembly morphology and fabricate single, double and triple nano",{"id":49,"funder":7,"programme":8,"title":50,"piName":51,"institution":52,"country":53,"year":13,"amount":14,"abstract":54},"openalex-european-research-council-award-erc2011-stg-279520-raspa","Insights into the Adsorption of Water and Small Alcohols on the Open-Metal Sites of Cu–BTC via Molecular Simulation","Sofı́a Calero","Universidad Pablo de Olavide","ES","We report a computational study of water and small alcohols on coordinatively unsaturated sites in the Cu–BTC metal–organic framework using Monte Carlo simulations. Binding energies and characteristic distances with copper centers are in agreement with these obtained from experiments and theoretical methods revealing the reliability of the classical force fields to describe the microscopic behavior. We rationalized the adsorption isotherms in terms of copper solvation and molecular association. ",{"id":56,"funder":7,"programme":8,"title":57,"piName":58,"institution":59,"country":21,"year":13,"amount":14,"abstract":60},"openalex-european-research-council-award-gedentqopt-erc-starting-grant-proj","Entanglement negativity in the harmonic chain out of equilibrium","Zoltán Zimborás","University College London","We study the entanglement in a chain of harmonic oscillators driven out of equilibrium by preparing the two sides of the system at different temperatures, and subsequently joining them together. The steady state is constructed explicitly and the logarithmic negativity is calculated between two adjacent segments of the chain. We find that, for low temperatures, the steady-state entanglement is a sum of contributions pertaining to left-and right-moving excitations emitted from the two reservoirs. ",{"id":62,"funder":7,"programme":8,"title":63,"piName":64,"institution":65,"country":66,"year":13,"amount":14,"abstract":67},"openalex-european-research-council-award-erc-stg-307207","Controlling Rigid Formations of Mobile Agents Under Inconsistent Measurements","Hector Garcia de Marina","University of Groningen","NL","Despite the great success of using gradient-based controllers to stabilize rigid formations of autonomous agents in the past years, surprising yet intriguing undesirable collective motions have been reported recently, when inconsistent measurements are used in the agents' local controllers. To make the existing gradient control robust against such measurement inconsistency, we exploit local estimators following the well-known internal model principle for robust output regulation control. The new",{"id":69,"funder":7,"programme":8,"title":70,"piName":71,"institution":72,"country":28,"year":13,"amount":14,"abstract":73},"openalex-european-research-council-award-erc-stg-thomale-336012","Numerical exploration of spontaneous broken symmetries in multiorbital Hubbard models","Y. F. Kung","SLAC National Accelerator Laboratory","We study three proposals for broken symmetry in the cuprate pseudogap---oxygen antiferromagnetism, ${\\ensuremath{\\Theta}}_{II}$ orbital loop currents, and circulating currents involving apex oxygens---through numerical exploration of multiorbital Hubbard models. Our numerically exact results show no evidence for the existence of oxygen antiferromagnetic order or the ${\\ensuremath{\\Theta}}_{II}$ phase in the three-orbital Hubbard model. The model also fails to sustain an ordered current pattern e",{"id":75,"funder":7,"programme":8,"title":76,"piName":77,"institution":78,"country":53,"year":13,"amount":14,"abstract":79},"openalex-european-research-council-award-stg-307609","Pyrene-based mechanically interlocked SWNTs","Emilio M. Pérez","Madrid Institute for Advanced Studies","The synthesis of rotaxane-type species composed of pyrene macrocycles and SWNTs as linear components is described. Pyrene-SWNT interactions help template the ring-closing metathesis of U-shaped precursors around the nanotubes.",{"id":81,"funder":7,"programme":8,"title":82,"piName":83,"institution":84,"country":85,"year":13,"amount":14,"abstract":86},"openalex-european-research-council-award-erc-stg-2012-311318-protdyn2function","Atomic Model of a Cell-Wall Cross-Linking Enzyme in Complex with an Intact Bacterial Peptidoglycan","Paul Schanda","Centre National de la Recherche Scientifique","FR","The maintenance of bacterial cell shape and integrity is largely attributed to peptidoglycan, a highly cross-linked biopolymer. The transpeptidases that perform this cross-linking are important targets for antibiotics. Despite this biomedical importance, to date no structure of a protein in complex with an intact bacterial peptidoglycan has been resolved, primarily due to the large size and flexibility of peptidoglycan sacculi. Here we use solid-state NMR spectroscopy to derive for the first tim",{"id":88,"funder":7,"programme":8,"title":89,"piName":90,"institution":91,"country":53,"year":13,"amount":14,"abstract":92},"openalex-european-research-council-award-erc-2009-stg-239910","Building Complexity in O\u003Csub>2\u003C\u002Fsub>-Binding Copper Complexes. Site-Selective Metalation and Intermolecular O\u003Csub>2\u003C\u002Fsub>-Binding at Dicopper and Heterometallic Complexes Derived from an Unsymmetric Ligand","Joan Serrano‐Plana","Universitat de Girona","A novel unsymmetric dinucleating ligand (L(N3N4)) combining a tridentate and a tetradentate binding sites linked through a m-xylyl spacer was synthesized as ligand scaffold for preparing homo- and dimetallic complexes, where the two metal ions are bound in two different coordination environments. Site-selective binding of different metal ions is demonstrated. L(N3N4) is able to discriminate between Cu(I) and a complementary metal (M' = Cu(I), Zn(II), Fe(II), Cu(II), or Ga(III)) so that pure hete",{"id":94,"funder":7,"programme":8,"title":95,"piName":96,"institution":97,"country":12,"year":13,"amount":14,"abstract":98},"openalex-european-research-council-award-erc-stg-no-258325","Phase-noise protection in quantum-enhanced differential interferometry","Luca Pezzè","Istituto Nazionale di Ottica","Descrizione di stati quantistici entanglati che offrono sensibilità sub shot noise di una fase differenziale tra due interferometri affetti dallo stesso rumore",{"id":100,"funder":7,"programme":8,"title":101,"piName":102,"institution":103,"country":53,"year":13,"amount":14,"abstract":104},"openalex-european-research-council-award-starting-grant-polydot","Increased short circuit current in an azafullerene-based organic solar cell","Aurélien Viterisi","Observatori de l'Ebre","We report the synthesis of a solution-processable, dodecyloxyphenyl-substituted azafullerene monoadduct (DPC59N) and its application as electron acceptor in bulk heterojunction organic solar cells (BHJ-OSCs). Due to its relatively strong absorption of visible light, DPC59N outperforms PC60BM in respect to short circuit current (JSC) and external quantum efficiency (EQE) in blends with donor P3HT.",{"id":106,"funder":7,"programme":8,"title":107,"piName":108,"institution":109,"country":110,"year":13,"amount":14,"abstract":111},"openalex-european-research-council-award-stg-203239-nomad","Ultrafast magnetization switching by spin-orbit torques","Kévin Garello","ETH Zurich","CH","Spin-orbit torques induced by spin Hall and interfacial effects in heavy metal\u002Fferromagnetic bilayers allow for a switching geometry based on in-plane current injection. Using this geometry, we demonstrate deterministic magnetization reversal by current pulses ranging from 180 ps to ms in Pt\u002FCo\u002FAlOx dots with lateral dimensions of 90 nm. We characterize the switching probability and critical current Ic as a function of pulse length, amplitude, and external field. Our data evidence two distinct r",{"id":113,"funder":7,"programme":8,"title":114,"piName":115,"institution":116,"country":12,"year":13,"amount":14,"abstract":117},"openalex-european-research-council-award-erc2011-stg-277755","Plasmon Enhanced Light Harvesting: Multiscale Modeling of the FMO Protein Coupled with Gold Nanoparticles","Oliviero Andreussi","University of Pisa","Plasmonic systems, such as metal nanoparticles, are becoming increasingly important in spectroscopies and devices because of their ability to enhance, even by several orders of magnitude, the photophysical properties of neighboring systems. In particular, it has been shown both theoretically and experimentally that combining nanoplasmonic devices with natural light-harvesting proteins substantially increases the fluorescence and absorption properties of the system. This kind of biohybrid device ",{"id":119,"funder":7,"programme":8,"title":120,"piName":121,"institution":122,"country":123,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-ers-2010-stg-263441","Childhood bone tuberculosis from Roman Pécs, Hungary","Lucia Hlavenková","Charles University","CZ",{"id":125,"funder":7,"programme":8,"title":126,"piName":127,"institution":128,"country":21,"year":13,"amount":14,"abstract":129},"openalex-european-research-council-award-erc-2009-stg-240500-dedigrowth","Morphology – composition correlations in carbon nanotubes synthesised with nitrogen and phosphorus containing precursors","Rebecca J. Nicholls","Oxfam","We have correlated the elemental composition with the structure of multi-wall carbon nanotubes synthesised with nitrogen and phosphorus containing precursors and identified two chemically distinct dominant morphologies. The first type are cone-structured tubes and the second are nanotubes with fewer walls which can accommodate N2 gas along their inner channel and contain up to ten times more nitrogen than the cone-structured nanotubes. Phosphorus was present in the catalyst particles but was not",{"id":131,"funder":7,"programme":8,"title":132,"piName":133,"institution":134,"country":135,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2010-stg","What shape is your neighbourhood? Investigating the micro geographies of physical activity","Vivienne Ivory","University of Otago","NZ",{"id":137,"funder":7,"programme":8,"title":138,"piName":139,"institution":140,"country":141,"year":13,"amount":14,"abstract":142},"openalex-european-research-council-award-starting-grant-239953","Anti-aliasing Wiener filtering for wave-front reconstruction in the spatial-frequency domain for high-order astronomical adaptive-optics systems","Carlos Correia","Universidade do Porto","PT","Computationally efficient wave-front reconstruction techniques for astronomical adaptive-optics (AO) systems have seen great development in the past decade. Algorithms developed in the spatial-frequency (Fourier) domain have gathered much attention, especially for high-contrast imaging systems. In this paper we present the Wiener filter (resulting in the maximization of the Strehl ratio) and further develop formulae for the anti-aliasing (AA) Wiener filter that optimally takes into account high-",{"id":144,"funder":7,"programme":8,"title":145,"piName":146,"institution":147,"country":148,"year":13,"amount":14,"abstract":149},"openalex-european-research-council-award-erc-2012-stg-309831","Data Processing Has Major Impact on the Outcome of Quantitative Label-Free LC-MS Analysis","Aakash Chawade","Medicon Village","SE","High-throughput multiplexed protein quantification using mass spectrometry is steadily increasing in popularity, with the two major techniques being data-dependent acquisition (DDA) and targeted acquisition using selected reaction monitoring (SRM). However, both techniques involve extensive data processing, which can be performed by a multitude of different software solutions. Analysis of quantitative LC-MS\u002FMS data is mainly performed in three major steps: processing of raw data, normalization, ",{"id":151,"funder":7,"programme":8,"title":152,"piName":153,"institution":109,"country":110,"year":13,"amount":14,"abstract":154},"openalex-european-research-council-award-stg-2012-306877","Appearance-mimicking surfaces","Christian Schüller","We consider the problem of reproducing the look and the details of a 3D object on a surface that is confined to a given volume. Classic examples of such \"appearance-mimicking\" surfaces are bas-reliefs: decorations and artwork depicting recognizable 3D scenes using only a thin volumetric space. The design of bas-reliefs has fascinated humankind for millennia and it is extensively used on coins, medals, pottery and other art forms. We propose a unified framework to create surfaces that depict cert",{"id":156,"funder":7,"programme":8,"title":157,"piName":158,"institution":59,"country":21,"year":13,"amount":14,"abstract":159},"openalex-european-research-council-award-stg-2013-335373","Creating works-like prototypes of mechanical objects","Bong-Jin Koo","Designers often create physical works-like prototypes early in the product development cycle to explore possible mechanical architectures for a design. Yet, creating functional prototypes requires time and expertise, which discourages rapid design iterations. Designers must carefully specify part and joint parameters to ensure that parts move and fit and together in the intended manner. We present an interactive system that streamlines the process by allowing users to annotate rough 3D models wi",{"id":161,"funder":7,"programme":8,"title":162,"piName":163,"institution":164,"country":165,"year":13,"amount":14,"abstract":166},"openalex-european-research-council-award-shape-forge-stg-2012-307877-","Topology-constrained synthesis of vector patterns","Shizhe Zhou","University of Science and Technology Chittagong","BD","Decorative patterns are observed in many forms of art, typically enriching the visual aspect of otherwise simple shapes. Such patterns are especially difficult to create, as they often exhibit intricate structural details and at the same time have to precisely match the size and shape of the underlying geometry. In the field of Computer Graphics, several approaches have been proposed to automatically synthesize a decorative pattern along a curve, from an example. This empowers non expert users w",{"id":168,"funder":7,"programme":8,"title":169,"piName":170,"institution":14,"country":14,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2011-stg-282111","Protein amino-terminal modifications and proteomic approaches for N-terminal profiling","Oliver Schilling",{"id":172,"funder":7,"programme":8,"title":173,"piName":174,"institution":175,"country":53,"year":13,"amount":14,"abstract":176},"openalex-european-research-council-award-erc-stg-259082","Tunnel Conduction in Epitaxial Bilayers of Ferromagnetic LaCoO\u003Csub>3\u003C\u002Fsub>\u002FLa\u003Csub>2\u002F3\u003C\u002Fsub>Sr\u003Csub>1\u002F3\u003C\u002Fsub>MnO\u003Csub>3\u003C\u002Fsub> Deposited by a Chemical Solution Method","I. Lucas","Universidad de Zaragoza","We report magnetic and electronic transport measurements across epitaxial bilayers of ferromagnetic insulator LaCoO3 and half-metallic ferromagnet La2\u002F3Sr1\u002F3MnO3 (LCO\u002FLSMO: 3.5 nm\u002F20 nm) fabricated by a chemical solution method. The I-V curves at room temperature and 4K measured with conducting atomic force microscopy (CAFM) on well-defined patterned areas exhibit the typical features of a tunneling process. The curves have been fitted to the Simmons model to determine the height (φ) and width (",{"id":178,"funder":7,"programme":8,"title":179,"piName":180,"institution":181,"country":182,"year":13,"amount":14,"abstract":183},"openalex-european-research-council-award-erc-stg-260686","Predicting evolution from the shape of genealogical trees","Richard A. Neher","Max Planck Institute for Developmental Biology","DE","Given a sample of genome sequences from an asexual population, can one predict its evolutionary future? Here we demonstrate that the branching patterns of reconstructed genealogical trees contains information about the relative fitness of the sampled sequences and that this information can be used to predict successful strains. Our approach is based on the assumption that evolution proceeds by accumulation of small effect mutations, does not require species specific input and can be applied to a",{"id":185,"funder":7,"programme":8,"title":186,"piName":187,"institution":188,"country":182,"year":13,"amount":14,"abstract":189},"openalex-european-research-council-award-stg-307163","Absolute configuration assignment of a chiral molecule in the gas phase using foil-induced Coulomb explosion imaging","Philipp Herwig","Max Planck Society","Chiral molecules exist in two configurations that are nonsuperposable mirror images of one another. The underlying molecular structure is referred to as the absolute configuration. In chiral environments, the handedness of molecules influences their chemical characteristics dramatically, and therefore the determination of absolute configurations is of fundamental interest in organic chemistry and biology. Commonly applied techniques to assign absolute configuration are anomalous single-crystal x",{"id":191,"funder":7,"programme":8,"title":192,"piName":193,"institution":194,"country":21,"year":13,"amount":14,"abstract":195},"openalex-european-research-council-award-erc-2012-stg-307245","Design of a speed meter interferometer proof-of-principle experiment","Christian Gräf","University of Glasgow","The second generation of large scale interferometric gravitational wave (GW) detectors will be limited by quantum noise over a wide frequency range in their detection band. Further sensitivity improvements for future upgrades or new detectors beyond the second generation motivate the development of measurement schemes to mitigate the impact of quantum noise in these instruments. Two strands of development are being pursued to reach this goal, focusing both on modifications of the well-establishe",{"id":197,"funder":7,"programme":8,"title":198,"piName":199,"institution":200,"country":201,"year":13,"amount":14,"abstract":202},"openalex-european-research-council-award-stg-257360-mocapaf","The charging of neutral dimethylamine and dimethylamine-sulphuric acid clusters using protonated acetone","K. Ruusuvuori","University of Helsinki","FI","Abstract. Sulphuric acid is generally considered one of the most important substances taking part in atmospheric particle formation. However, in typical atmospheric conditions in the lower troposphere sulphuric acid and water alone are unable to form particles. It has been suggested that strong bases may stabilize sulphuric acid clusters so that particle formation may occur. More to the point, amines – strong organic bases – have become the subject of interest as possible cause for such stabilis",{"id":204,"funder":7,"programme":8,"title":205,"piName":206,"institution":207,"country":182,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2010-stg-259550","Error diffusion on meshes","Marc Alexa","Technische Universität Berlin",{"id":209,"funder":7,"programme":8,"title":210,"piName":211,"institution":212,"country":12,"year":13,"amount":14,"abstract":213},"openalex-european-research-council-award-stg-239898","Light-Triggered Thiol-Exchange on Gold Nanoparticles at Low Micromolar Concentrations in Water","Christian Franceschini","University of Padua","The place-exchange reaction of thiol-containing peptides in a cationic monolayer on gold nanoparticles occurs very rapidly at low micromolar concentrations in water with excellent control over the degree of substitution. The driving force for this process is the binding of anionic peptides to a cationic monolayer surface which causes a strong increase in the local concentration of thiols. The place-exchange reaction can be triggered by light using a photolabile protecting group on the thiol moie",{"id":215,"funder":7,"programme":8,"title":216,"piName":217,"institution":218,"country":182,"year":13,"amount":14,"abstract":219},"openalex-european-research-council-award-2009-stg-239838","Domain wall pinning in ultra-narrow electromigrated break junctions","Robert M. Reeve","Johannes Gutenberg University Mainz","The study of magnetic domain walls in constrained geometries is an important topic, yet when dealing with extreme nanoscale magnetic systems artefacts can often dominate the measurements and obscure the effects of intrinsic magnetic origin. In this work we study the evolution of domain wall depinning in electromigrated ferromagnetic junctions which are both initially fabricated and subsequently tailored in-situ in clean ultra-high vacuum conditions. Carefully designed Ni(80)Fe(20) (Permalloy) no",{"id":221,"funder":7,"programme":8,"title":222,"piName":223,"institution":109,"country":110,"year":13,"amount":14,"abstract":224},"openalex-european-research-council-award-erc-starting-grant-under-contract-no-277910-","The nature of excess electrons in anatase and rutile from hybrid DFT and RPA","Joost VandeVondele","The behavior of excess electrons in undoped and defect free bulk anatase and rutile TiO2 has been investigated by state-of-the-art electronic structure methods including hybrid density functional theory (DFT) and the random phase approximation (RPA). Consistent with experiment, charge trapping and polaron formation is observed in both anatase and rutile. The difference in the anisotropic shape of the polarons is characterized, confirming for anatase the large polaron picture. For anatase, where ",{"id":226,"funder":7,"programme":8,"title":227,"piName":228,"institution":229,"country":21,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2010-stg-262853","Your place or mine: Shared sensory experiences elicit a remapping of peripersonal space","Lara Maister","Royal Holloway University of London",{"id":231,"funder":7,"programme":8,"title":232,"piName":233,"institution":234,"country":182,"year":13,"amount":14,"abstract":235},"openalex-european-research-council-award-erc-stg-2013-336012","Rashba spin-orbit coupling in the Kane-Mele-Hubbard model","Manuel Laubach","University of Würzburg","Spin-orbit (SO) coupling is the crucial parameter to drive topological-insulating phases in electronic band models. In particular, the generic emergence of SO coupling involves the Rashba term which fully breaks the SU(2) spin symmetry. As soon as interactions are taken into account, however, many theoretical studies have to content themselves with the analysis of a simplified U(1)-conserving SO term without Rashba coupling. We intend to fill this gap by studying the Kane-Mele-Hubbard (KMH) mode",{"id":237,"funder":7,"programme":8,"title":238,"piName":239,"institution":240,"country":182,"year":13,"amount":14,"abstract":241},"openalex-european-research-council-award-erc-2010-stg-260991","Four dimensional hybrid ultrasound and optoacoustic imaging via passive element optical excitation in a hand-held probe","Thomas Felix Fehm","Technical University of Munich","Ultrasonography and optoacoustic imaging share powerful advantages related to the natural aptitude for real-time image rendering with high resolution, the hand-held operation, and lack of ionizing radiation. The two methods also possess very different yet highly complementary advantages of the mechanical and optical contrast in living tissues. Nonetheless, efficient integration of these modalities remains challenging owing to the fundamental differences in the underlying physical contrast, optim",{"id":243,"funder":7,"programme":8,"title":244,"piName":245,"institution":246,"country":110,"year":13,"amount":14,"abstract":247},"openalex-european-research-council-award-erc-2012-stg-306630-matisse","Broadly tunable source around 2050 nm based on wideband parametric conversion and thulium–holmium amplification cascade","Adrien Billat","École Polytechnique Fédérale de Lausanne","We report the design of a short-wave infrared continuous-wave light source featuring a 20 mW average output power, and with a wavelength that can be freely selected in the 2000-2100 nm range amid a low power ripple. The operating principle relies on the simultaneous broadband parametric conversion of two seeds in a highly nonlinear silica fiber pumped in the L-band followed by amplification and equalization in an appended thulium- and holmium- doped fiber cascade directly pumped by their respect",{"id":249,"funder":7,"programme":8,"title":250,"piName":251,"institution":52,"country":53,"year":13,"amount":14,"abstract":252},"openalex-european-research-council-award-erc-stg-279520","Insights on the Anomalous Adsorption of Carbon Dioxide in LTA Zeolites","Ana Martín-Calvo","We use a combination of experiments and molecular simulations to address the discrepancies of the force fields available in the literature to accurately reproduce CO2 adsorption in zeolites with high density of aluminum atoms and extra framework cations. We attribute these discrepancies to the fact that previous force fields are not parametrized to take into account the formation of carbonate-like complexes in these zeolites during CO2 adsorption. Our data show that the formation of carbonate-li",{"id":254,"funder":7,"programme":8,"title":255,"piName":256,"institution":257,"country":85,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-hotlhc-erc-2011-stg-279579","Radiation spectrum of a massive quark–gluon antenna","Manoel R. Calvo","Institut de Physique Théorique",{"id":259,"funder":7,"programme":8,"title":255,"piName":256,"institution":257,"country":85,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2011-stg-279579",{"id":261,"funder":7,"programme":8,"title":262,"piName":263,"institution":264,"country":53,"year":13,"amount":14,"abstract":265},"openalex-european-research-council-award-erc-2010-stg-260414","Batf3‐dependent CD103\u003Csup>+\u003C\u002Fsup> dendritic cells are major producers of IL‐12 that drive local Th1 immunity against \u003Ci>Leishmania major\u003C\u002Fi> infection in mice","David Sancho","Spanish National Centre for Cardiovascular Research","The role of different DC subsets in priming and maintenance of immunity against Leishmania major (L. major) infection is debated. The transcription factor basic leucine zipper transcription factor, ATF-like 3 (Batf3) is essential for the development of mouse CD103(+) DCs and some functions of CD8α(+) DCs. We found that CD103(+) DCs were significantly reduced in the dermis of Batf3-deficient C57BL\u002F6 mice. Batf3(-\u002F-) mice developed exacerbated and unresolved cutaneous pathology following a low dos",{"id":267,"funder":7,"programme":8,"title":268,"piName":269,"institution":270,"country":28,"year":13,"amount":14,"abstract":271},"openalex-european-research-council-award-erc-stg-thomale-2013-336012","Thermoelectric properties of Weyl and Dirac semimetals","Rex Lundgren","The University of Texas at Austin","We study the electronic contribution to the thermal conductivity and the thermopower of Weyl and Dirac semimetals using a semiclassical Boltzmann approach. We investigate the effect of various relaxation processes including disorder and interactions on the thermoelectric properties, and also consider doping away from the Weyl or Dirac point. We find that the thermal conductivity and thermopower have an interesting dependence on the chemical potential that is characteristic of the linear electron",{"id":273,"funder":7,"programme":8,"title":274,"piName":275,"institution":276,"country":148,"year":13,"amount":14,"abstract":277},"openalex-european-research-council-award-stg-282255","C‐peptide concentration, mortality and vascular complications in people with Type 2 diabetes. The Skaraborg Diabetes Register","Miriam Pikkemaat","Lund University","AIM: To study the prognosis of patients with newly diagnosed Type 2 diabetes in primary care in relation to their baseline C-peptide concentration. METHODS: C-peptide concentrations were determined in 399 patients aged \u003C 65 years with newly diagnosed Type 2 diabetes using the Skaraborg Diabetes Register, Sweden. Data on cardiovascular complications and death were extracted from national registers and a local study of retinopathy. Statistical analyses were performed using Cox regression. RESULTS:",{"id":279,"funder":7,"programme":8,"title":280,"piName":281,"institution":282,"country":85,"year":13,"amount":14,"abstract":283},"openalex-european-research-council-award-erc-2012-stg-20111109","Protective effects of n‐6 fatty acids‐enriched diet on intestinal ischaemia\u002Freperfusion injury involve lipoxin \u003Cscp>A\u003C\u002Fscp>\u003Csub>4\u003C\u002Fsub> and its receptor","Nathalie Vergnolle","Inserm","Background and Purpose Long‐term intake of dietary fatty acids is known to predispose to chronic inflammation, but their effects on acute intestinal ischaemia\u002Freperfusion ( I\u002FR ) injury is unknown. The aim of this study was to determine the consequences of a diet rich in n‐3 or n‐6 polyunsaturated fatty acids ( PUFA ) on intestinal I\u002FR ‐induced damage. Experimental Approach Mice were fed three different isocaloric diets: a balanced diet used as a control and two different PUFA ‐enriched diets, p",{"id":285,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":21,"year":13,"amount":14,"abstract":286},"openalex-european-research-council-award-erc-2011-stg-279363-hidgr","In Lovelock theories, gravity can travel faster or slower than light. The causal structure is determined by the characteristic hypersurfaces. We generalise a recent result of Izumi to prove that any Killing horizon is a characteristic hypersurface for all gravitational degrees of freedom of a Lovelock theory. Hence gravitational signals cannot escape from the region inside such a horizon. We investigate the hyperbolicity of Lovelock theories by determining the characteristic hypersurfaces for va",{"id":288,"funder":7,"programme":8,"title":289,"piName":290,"institution":109,"country":110,"year":13,"amount":14,"abstract":291},"openalex-european-research-council-award-starting-grant-307036","Explore-exploit in top-N recommender systems via Gaussian processes","Hastagiri P. Vanchinathan","We address the challenge of ranking recommendation lists based on click feedback by efficiently encoding similarities among users and among items. The key challenges are threefold: (1) combinatorial number of lists; (2) sparse feedback and (3) context dependent recommendations. We propose the CGPRank algorithm, which exploits prior information specified in terms of a Gaussian process kernel function, which allows to share feedback in three ways: Between positions in a list, between items, and be",{"id":293,"funder":7,"programme":8,"title":294,"piName":295,"institution":296,"country":21,"year":13,"amount":14,"abstract":297},"openalex-european-research-council-award-starting-grant-agreement-278576","Through the combining glass","Diego Martínez Plasencia","University of Bristol","Reflective optical combiners like beam splitters and two way mirrors are used in AR to overlap digital contents on the users' hands or bodies. Augmentations are usually unidirectional, either reflecting virtual contents on the user's body (Situated Augmented Reality) or augmenting user's reflections with digital contents (AR mirrors). But many other novel possibilities remain unexplored. For example, users' hands, reflected inside a museum AR cabinet, can allow visitors to interact with the arti",{"id":299,"funder":7,"programme":8,"title":300,"piName":301,"institution":302,"country":21,"year":13,"amount":14,"abstract":303},"openalex-european-research-council-award-erc-starting-grant-279541-imcolmat","Decoupled and simultaneous three-dimensional imaging and optical manipulation through a single objective","Arran Curran","University of Oxford","The combination of optical manipulation and threedimensional imaging is a central technique in fields ranging from medicine to physics. Using the objective lens simultaneously for optical trapping and imaging, however, inherently confines the trapping and imaging planes to the same focal plane. Here, we combine remote refocusing microscopy and optical trapping to optically decouple the imaging and trapping planes, achieving aberration-free three-dimensional imaging and simultaneous, decoupled op",{"id":305,"funder":7,"programme":8,"title":306,"piName":307,"institution":308,"country":53,"year":13,"amount":14,"abstract":309},"openalex-european-research-council-award-erc-2010-stg-258406","Costless Derivation of Dispersion Coefficients for Metal Surfaces","Neyvis Almora‐Barrios","Institut Català d'Investigació Química","Many common density functional theory methods used in the study of adsorption on metals lack dispersion contributions. Formulations like the random phase approximations would mitigate this error, but they are computationally too expensive. Therefore, semiempiric treatments based on dispersion coefficients turn out to be a practical solution. However, the parameters derived for atoms and molecules are not easily transferable to solids. In the case of metals, they cause severe overbinding as scree",{"id":311,"funder":7,"programme":8,"title":312,"piName":313,"institution":314,"country":182,"year":13,"amount":14,"abstract":315},"openalex-european-research-council-award-erc-stg-c3env-ga-256962","AuToGraFS: Automatic Topological Generator for Framework Structures","Matthew A. Addicoat","Constructor University","Metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) are recently notable examples of highly porous polymer frameworks with a raft of potential applications. Synthesis of these compounds is modular, with \"connectors\" and \"linkers\" able to be replaced almost at will in the fabrication of isoreticular frameworks (frameworks with the same underlying topology). The range of components available to form such framework structures is vast, leading to a \"combinatorial explosion\" proble",{"id":317,"funder":7,"programme":8,"title":318,"piName":319,"institution":240,"country":182,"year":13,"amount":14,"abstract":320},"openalex-european-research-council-award-erc-fp7-stg-240142","Fast one-dimensional wave-front propagation for x-ray differential phase-contrast imaging","Johannes Wolf","Numerical wave-optical simulations of X-ray differential phase-contrast imaging using grating interferometry require the oversampling of gratings and object structures in the range of few micrometers. Consequently, fields of view of few millimeters already use large amounts of a computer's main memory to store the propagating wave front, limiting the scope of the investigations to only small-scale problems. In this study, we apply an approximation to the Fresnel-Kirchhoff diffraction theory to o",{"id":322,"funder":7,"programme":8,"title":323,"piName":324,"institution":325,"country":85,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2010-stg-260515","New insights on food intake control by olfactory processes: The emerging role of the endocannabinoid system","Edgar Soria‐Gómez","Neurocentre Magendie",{"id":327,"funder":7,"programme":8,"title":328,"piName":329,"institution":116,"country":12,"year":13,"amount":14,"abstract":330},"openalex-european-research-council-award-erc-2011-stg-277755","Electronic Excitations in Nonpolar Solvents: Can the Polarizable Continuum Model Accurately Reproduce Solvent Effects?","Lorenzo Cupellini","In nonpolar solvents, both electrostatic and nonelectrostatic interactions play a role in tuning the electronic excitations of molecular solutes. This specificity makes the application of continuum solvation models a challenge. Here, we propose a strategy for the calculation of solvatochromic shifts on absorption spectra, using a coupling of the polarizable continuum model with a time-dependent density functional theory framework, which explicitly accounts for dispersion and repulsion, as well a",{"id":332,"funder":7,"programme":8,"title":333,"piName":334,"institution":335,"country":66,"year":13,"amount":14,"abstract":336},"openalex-european-research-council-award-2011-stg-280255","Quantifying Stickiness: Thermodynamic Characterization of Intramolecular Domain Interactions To Guide the Design of Förster Resonance Energy Transfer Sensors","Laurens H. Lindenburg","Eindhoven University of Technology","The introduction of weak, hydrophobic interactions between fluorescent protein domains (FPs) can substantially increase the dynamic range (DR) of Förster resonance energy transfer (FRET)-based sensor systems. Here we report a comprehensive thermodynamic characterization of the stability of a range of self-associating FRET pairs. A new method is introduced that allows direct quantification of the stability of weak FP interactions by monitoring intramolecular complex formation as a function of ure",{"id":338,"funder":7,"programme":8,"title":339,"piName":340,"institution":341,"country":182,"year":13,"amount":14,"abstract":342},"openalex-european-research-council-award-erc-2011-stg-282111-proteasys","Carboxyterminal Protein Processing in Health and Disease: Key Actors and Emerging Technologies","Agnese Petrera","University of Freiburg","Carboxypeptidases are important mediators of cellular behavior. Through C-terminal truncations, they alter protein functionality and participate in proteome turnover. Similarly, carboxypeptidases shape the human peptidome by targeting neuroendocrine and vasoactive peptides, thereby regulating signaling pathways in the nervous and cardiovascular systems as well as in embryonic development. Carboxypeptidases are widely connected to various pathological processes such as carcinogenesis and neurodeg",{"id":344,"funder":7,"programme":8,"title":345,"piName":346,"institution":347,"country":53,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-stg-256997-czosqp","Dyadic harmonic analysis beyond doubling measures","Luis Daniel López-Sánchez","Consejo Superior de Investigaciones Científicas",{"id":349,"funder":7,"programme":8,"title":350,"piName":351,"institution":352,"country":12,"year":13,"amount":14,"abstract":353},"openalex-european-research-council-award-erc-2007-stg","Thermal noise of mechanical oscillators in steady states with a heat flux","L. Conti","Istituto Nazionale di Fisica Nucleare","We present an experimental investigation of the statistical properties of the position fluctuations of low-loss oscillators in nonequilibrium steady states. The oscillators are coupled to a heat bath, and a nonequilibrium steady state is produced by flowing a constant heat flux, setting a temperature difference across the oscillators. We investigated the distribution of the measurements of the square of the oscillator position and searched for signs of changes with respect to the equilibrium cas",{"id":355,"funder":7,"programme":8,"title":356,"piName":357,"institution":20,"country":21,"year":13,"amount":14,"abstract":358},"openalex-european-research-council-award-stg-307224","To have and have not","Quentin Stafford-Fraser","We address the problem of locking and unlocking a device, such as a laptop, a phone or a security token, based on the absence or presence of the user. We detect user presence by sensing the proximity of a subset of their possessions, making the process automatic and effortless. As in previous work, a master key unlocks the device and a secret-sharing scheme allows us to reconstruct this master key in the presence of k-out-of-n items. We extend this basic scheme in various directions, e.g. by all",{"id":360,"funder":7,"programme":8,"title":361,"piName":362,"institution":363,"country":110,"year":13,"amount":14,"abstract":364},"openalex-european-research-council-award-erc-2012-stg-307760","On-surface synthesis of a two-dimensional porous coordination network: Unraveling adsorbate interactions","Manfred Matena","University of Basel","We present a detailed experimental and theoretical characterization of the adsorption of the perylene derivative 4,9-diaminoperylene-quinone-3,10-diimine (DPDI) on Cu(111) and compare it to its threefold dehydrogenated derivative 3deh-DPDI, which forms in a surface reaction upon annealing. While DPDI itself does not give rise to long-range ordered structures due to lack of appropriate functional groups, 3deh-DPDI acts as an exoligand in a Cu-coordinated honeycomb network on Cu(111). The main foc",{"id":366,"funder":7,"programme":8,"title":367,"piName":368,"institution":369,"country":85,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-stg-307184","Light sterile neutrinos in particle physics: Experimental status","T. Lasserre","Institut de Recherche sur les Lois Fondamentales de l'Univers",{"id":371,"funder":7,"programme":8,"title":372,"piName":373,"institution":374,"country":21,"year":13,"amount":14,"abstract":375},"openalex-european-research-council-award-erc-2012-stg-311460","Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities","Carles Galdeano","University of Dundee","E3 ubiquitin ligases are attractive targets in the ubiquitin-proteasome system, however, the development of small-molecule ligands has been rewarded with limited success. The von Hippel-Lindau protein (pVHL) is the substrate recognition subunit of the VHL E3 ligase that targets HIF-1α for degradation. We recently reported inhibitors of the pVHL:HIF-1α interaction, however they exhibited moderate potency. Herein, we report the design and optimization, guided by X-ray crystal structures, of a liga",{"id":377,"funder":7,"programme":8,"title":378,"piName":379,"institution":380,"country":28,"year":13,"amount":14,"abstract":381},"openalex-european-research-council-award-stg-307036","Streaming submodular maximization","Ashwinkumar Badanidiyuru","Cornell University","How can one summarize a massive data set \"on the fly\", i.e., without even having seen it in its entirety? In this paper, we address the problem of extracting representative elements from a large stream of data. I.e., we would like to select a subset of say k data points from the stream that are most representative according to some objective function. Many natural notions of \"representativeness\" satisfy submodularity, an intuitive notion of diminishing returns. Thus, such problems can be reduced",{"id":383,"funder":7,"programme":8,"title":384,"piName":385,"institution":386,"country":53,"year":13,"amount":14,"abstract":387},"openalex-european-research-council-award-erc-stg-2011-278860","Hydration Induced Stress on DNA Monolayers Grafted on Microcantilevers","Carmen M. Domínguez","Centro Nacional de Microelectrónica","Surface tethered single-stranded DNA films are relevant biorecognition layers for oligonucleotide sequence identification. Also, hydration induced effects on these films have proven useful for the nanomechanical detection of DNA hybridization. Here, we apply nanomechanical sensors and atomic force microscopy to characterize in air and upon varying relative humidity conditions the swelling and deswelling of grafted single stranded and double stranded DNA films. The combination of these techniques",{"id":389,"funder":7,"programme":8,"title":390,"piName":391,"institution":240,"country":182,"year":13,"amount":14,"abstract":392},"openalex-european-research-council-award-stg-240142","Phase Unwrapping in Spectral X-Ray Differential Phase-Contrast Imaging With an Energy-Resolving Photon-Counting Pixel Detector","Franz Michael Epple","Grating-based differential phase-contrast imaging has proven to be feasible with conventional X-ray sources. The polychromatic spectrum generally limits the performance of the interferometer but benefit can be gained with an energy-sensitive detector. In the presented work, we employ the energy-discrimination capability to correct for phase-wrapping artefacts. We propose to use the phase shifts, which are measured in distinct energy bins, to estimate the optimal phase shift in the sense of maxim",{"id":394,"funder":7,"programme":8,"title":390,"piName":391,"institution":240,"country":182,"year":13,"amount":14,"abstract":392},"openalex-european-research-council-award-stg-279753",{"id":396,"funder":7,"programme":8,"title":397,"piName":398,"institution":399,"country":182,"year":13,"amount":14,"abstract":400},"openalex-european-research-council-award-erc-2012-stg-308246","Functional programming for dynamic and large data with self-adjusting computation","Yan Chen","Max Planck Institute for Software Systems","Combining type theory, language design, and empirical work, we present techniques for computing with large and dynamically changing datasets. Based on lambda calculus, our techniques are suitable for expressing a diverse set of algorithms on large datasets and, via self-adjusting computation, enable computations to respond automatically to changes in their data. To improve the scalability of self-adjusting computation, we present a type system for precise dependency tracking that minimizes the t",{"id":402,"funder":7,"programme":8,"title":403,"piName":404,"institution":405,"country":21,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-stg-307061","Synthesis and characterization of redox active cyrhetrene–triazole click products","Gregory G. Wildgoose","University of East Anglia",{"id":407,"funder":7,"programme":8,"title":408,"piName":409,"institution":410,"country":85,"year":13,"amount":14,"abstract":411},"openalex-european-research-council-award-erc-starting-grant-du-283953","Risk Aversion, Overconfidence and Private Information as Determinants of Majority Thresholds","Giuseppe Attanasi","Université de Strasbourg","Abstract We present and experimentally test a theoretical model of majority threshold determination as a function of voters’ risk preferences. The experimental results confirm the theoretical prediction of a positive correlation between the voter's risk aversion and the corresponding preferred majority threshold. Furthermore, the experimental results show that a voter's preferred majority threshold negatively relates to the voter's confidence about how others will vote. Moreover, in a treatment ",{"id":413,"funder":7,"programme":8,"title":414,"piName":415,"institution":416,"country":201,"year":13,"amount":14,"abstract":417},"openalex-european-research-council-award-erc-2011-stg-278698-precise-nano-","Electronic States at the Graphene–Hexagonal Boron Nitride Zigzag Interface","Robert Drost","Aalto University","The electronic properties of graphene edges have been predicted to depend on their crystallographic orientation. The so-called zigzag (ZZ) edges haven been extensively explored theoretically and proposed for various electronic applications. However, their experimental study remains challenging due to the difficulty in realizing clean ZZ edges without disorder, reconstructions, or the presence of chemical functional groups. Here, we propose the ZZ-terminated, atomically sharp interfaces between g",{"id":419,"funder":7,"programme":8,"title":420,"piName":421,"institution":302,"country":21,"year":13,"amount":14,"abstract":422},"openalex-european-research-council-award-erc-2009-stg-240500","Effects of temperature and ammonia flow rate on the chemical vapour deposition growth of nitrogen-doped graphene","Nicole Grobert","We doped graphene in situ during synthesis from methane and ammonia on copper in a low-pressure chemical vapour deposition system, and investigated the effect of the synthesis temperature and ammonia concentration on the growth. Raman and X-ray photoelectron spectroscopy was used to investigate the quality and nitrogen content of the graphene and demonstrated that decreasing the synthesis temperature and increasing the ammonia flow rate results in an increase in the concentration of nitrogen dop",{"id":424,"funder":7,"programme":8,"title":425,"piName":426,"institution":302,"country":21,"year":13,"amount":14,"abstract":427},"openalex-european-research-council-award-erc-2010-stg-258600","Infrared Spectroscopy Provides Insight into the Role of Dioxygen in the Nitrosylation Pathway of a [2Fe2S] Cluster Iron–Sulfur Protein","Daniel B. Grabarczyk","We use infrared spectroscopy to demonstrate the critical role that trace O2 plays in determining the products formed when a [2Fe2S] cluster protein reacts with nitric oxide (NO). The observed importance of O2 may have physiological relevance, as many pathogens sense NO using iron-sulfur proteins and will be exposed to NO in an aerobic environment during a mammalian immune response. We show that the [2Fe2S]-containing spinach ferredoxin I undergoes reaction with NO at pH 6.0, with the proportion ",{"id":429,"funder":7,"programme":8,"title":430,"piName":431,"institution":14,"country":14,"year":13,"amount":14,"abstract":432},"openalex-european-research-council-award-erc-stg-24002","Technical Note: Large overestimation of \u003Ci>p\u003C\u002Fi> CO \u003Csub>2\u003C\u002Fsub> calculated from pH and alkalinity in acidic, organic-rich freshwaters","Gwénaël Abril","Abstract. Inland waters have been recognized as a~significant source of carbon dioxide (CO2) to the atmosphere at the global scale. Fluxes of CO2 between aquatic systems and the atmosphere are calculated from the gas transfer velocity and the water-air gradient of the partial pressure of CO2 (pCO2). Nowadays, direct measurements of water pCO2 remain scarce in freshwaters and most published pCO2 data are calculated from temperature, pH and total alkalinity (TA). Here, we compare calculated (pH an",{"id":434,"funder":7,"programme":8,"title":435,"piName":436,"institution":59,"country":21,"year":13,"amount":14,"abstract":437},"openalex-european-research-council-award-smartgeometry-stg-2013-335373-","A study of image colourfulness","Cristina Amati","Colourfulness is often thought of as a mere measure of quantity of colour, but user studies suggest that there are more factors influencing the perception of colourfulness. Boosting and enhancing colours are operations often performed for improving image aesthetics, but the relationship between colourfulness and aesthetics has not been thoroughly explored. By gathering perceptual data from a large-scale user study we have shown how existing colourfulness metrics relate to it and that there is no",{"id":439,"funder":7,"programme":8,"title":440,"piName":441,"institution":442,"country":443,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2007-stg-20777-7","Pulmonary overexpression of inhibitor κBα decreases the severity of ventilator-induced lung injury in a rat model","Mairéad Hayes","Ollscoil na Gaillimhe – University of Galway","IE",{"id":445,"funder":7,"programme":8,"title":446,"piName":447,"institution":448,"country":85,"year":13,"amount":14,"abstract":449},"openalex-european-research-council-award-shapeforge-stg-2012-307877-","Bridging the gap","Jérémie Dumas","Institut national de recherche en sciences et technologies du numérique","Fused Filament Fabrication (FFF) is the process of 3D printing objects from melted plastic filament. The hot plastic exits a nozzle and fuses with the part just below, adding a layer of material to the object being formed. However, filament can only be deposited on top of an existing surface. Therefore, overhangs require a disposable support structure to be printed, temporarily supporting the threads of plastic that would otherwise hang in empty space. Existing techniques for support generation ",{"id":451,"funder":7,"programme":8,"title":452,"piName":453,"institution":454,"country":455,"year":13,"amount":14,"abstract":456},"openalex-european-research-council-award-imodel-stg-2012-306877-smartgeometry-stg-2013-335373-","Meta-representation of shape families","Noa Fish","Tel Aviv University","IL","We introduce a meta-representation that represents the essence of a family of shapes. The meta-representation learns the configurations of shape parts that are common across the family, and encapsulates this knowledge with a system of geometric distributions that encode relative arrangements of parts. Thus, instead of predefined priors, what characterizes a shape family is directly learned from the set of input shapes. The meta-representation is constructed from a set of co-segmented shapes with",{"id":458,"funder":7,"programme":8,"title":459,"piName":460,"institution":109,"country":110,"year":13,"amount":14,"abstract":461},"openalex-european-research-council-award-imodel-stg-2012-306877-","Tangible and modular input device for character articulation","Alec Jacobson","Articulation of 3D characters requires control over many degrees of freedom: a difficult task with standard 2D interfaces. We present a tangible input device composed of interchangeable, hot-pluggable parts. Embedded sensors measure the device's pose at rates suitable for real-time editing and animation. Splitter parts allow branching to accommodate any skeletal tree. During assembly, the device recognizes topological changes as individual parts or pre-assembled subtrees are plugged and unplugge",{"id":463,"funder":7,"programme":8,"title":464,"piName":465,"institution":466,"country":28,"year":13,"amount":14,"abstract":467},"openalex-european-research-council-award-erc-2011-stg-280135","Simulating articulated subspace self-contact","Yun Teng","University of California, Santa Barbara","We present an efficient new subspace method for simulating the self-contact of articulated deformable bodies, such as characters. Self-contact is highly structured in this setting, as the limited space of possible articulations produces a predictable set of coherent collisions. Subspace methods can leverage this coherence, and have been used in the past to accelerate the collision detection stage of contact simulation. We show that these methods can be used to accelerate the entire contact compu",{"id":469,"funder":7,"programme":8,"title":470,"piName":471,"institution":472,"country":443,"year":13,"amount":14,"abstract":473},"openalex-european-research-council-award-stg-208561","Solvent-Dependent Switch of Ligand Donor Ability and Catalytic Activity of Ruthenium(II) Complexes Containing Pyridinylidene Amide (PYA) N-Heterocyclic Carbene Hybrid Ligands","Vivienne Leigh","University College Dublin","Chelating ligands incorporating both N-[1-alkylpyridin-4(1H)-ylidene]amide (PYA) and N-heterocyclic carbene (NHC) donor sites were prepared and used for the synthesis of ruthenium(II) complexes. Cyclic voltammetry, NMR, and UV-vis spectroscopy of the complexes indicate a solvent-dependent contribution of the limiting resonance structures associated with the ligand in solution. The neutral pyridylidene imine structure is more pronounced in apolar solvents (CH2Cl2), while the mesoionic pyridinium ",{"id":475,"funder":7,"programme":8,"title":476,"piName":477,"institution":478,"country":53,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-stg-2012-233764","Retrotransposons in pluripotent cells: Impact and new roles in cellular plasticity","Ángela Macia","Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research",{"id":480,"funder":7,"programme":8,"title":481,"piName":482,"institution":483,"country":46,"year":13,"amount":14,"abstract":484},"openalex-european-research-council-award-starting-grant-fp7-project-dedom-grant-no-207441-","Orbital-dependent second-order scaled-opposite-spin correlation functionals in the optimized effective potential method","Ireneusz Grabowski","Institute of Physics","The performance of correlated optimized effective potential (OEP) functionals based on the spin-resolved second-order correlation energy is analysed. The relative importance of singly- and doubly- excited contributions as well as the effect of scaling the same- and opposite- spin components is investigated in detail comparing OEP results with Kohn-Sham (KS) quantities determined via an inversion procedure using accurate ab initio electronic densities. Special attention is dedicated in particular",{"id":486,"funder":7,"programme":8,"title":487,"piName":488,"institution":14,"country":14,"year":13,"amount":14,"abstract":489},"openalex-european-research-council-award-erc-2011-stg-280255","Mitochondrial and ER-Targeted eCALWY Probes Reveal High Levels of Free Zn\u003Csup>2+\u003C\u002Fsup>","Pauline Chabosseau","Zinc (Zn2+) ions are increasingly recognized as playing an important role in cellular physiology. Whereas the free Zn2+ concentration in the cytosol has been established to be 0.1-1 nM, the free Zn2+ concentration in subcellular organelles is not well-established. Here, we extend the eCALWY family of genetically encoded Förster Resonance Energy Transfer (FRET) Zn2+ probes to permit measurements in the endo(sarco)plasmic reticulum (ER) and mitochondrial matrix. Deployed in a variety of mammalian ",{"id":491,"funder":7,"programme":8,"title":492,"piName":493,"institution":302,"country":21,"year":13,"amount":14,"abstract":494},"openalex-european-research-council-award-energybiocatalysis-erc-2010-stg-258600erc","Unusual Reaction of [NiFe]-Hydrogenases with Cyanide","Suzannah V. Hexter","Cyanide reacts rapidly with [NiFe]-hydrogenases (hydrogenase-1 and hydrogenase-2 from Escherichia coli) under mild oxidizing conditions, inhibiting the electrocatalytic oxidation of hydrogen as recorded by protein film electrochemistry. Electrochemical, EPR, and FTIR measurements show that the final enzyme product, formed within a second (even under 100% H2), is the resting state known as Ni-B, which contains a hydroxido-bridged species, Ni(III)-μ(OH)-Fe(II), at the active site. \"Cyanide inhibit",{"id":496,"funder":7,"programme":8,"title":497,"piName":498,"institution":499,"country":500,"year":13,"amount":14,"abstract":501},"openalex-european-research-council-award-erc-2013-stg-335086-lattac","LLL reducing with the most significant bits","Saruchi Saruchi","Indian Institute of Technology Indore","IN","Let B be a basis of a Euclidean lattice, and B an approximation thereof. We give a sufficient condition on the closeness between B and B so that an LLL-reducing transformation U for B remains valid for B. Further, we analyse an efficient reduction algorithm when B is itself a small deformation of an LLL-reduced basis. Applications include speeding-up reduction by keeping only the most significant bits of B, reducing a basis that is only approximately known, and efficiently batching LLL reduction",{"id":503,"funder":7,"programme":8,"title":504,"piName":505,"institution":506,"country":182,"year":13,"amount":14,"abstract":507},"openalex-european-research-council-award-erc-stg-210356","A comprehensive high‐resolution mass spectrometry approach for characterization of metabolites by combination of ambient ionization, chromatography and imaging methods","Andreas Römpp","University of Giessen","RATIONALE: An ideal method for bioanalytical applications would deliver spatially resolved quantitative information in real time and without sample preparation. In reality these requirements can typically not be met by a single analytical technique. Therefore, we combine different mass spectrometry approaches: chromatographic separation, ambient ionization and imaging techniques, in order to obtain comprehensive information about metabolites in complex biological samples. METHODS: Samples were a",{"id":509,"funder":7,"programme":8,"title":510,"piName":511,"institution":363,"country":110,"year":13,"amount":14,"abstract":512},"openalex-european-research-council-award-erc-2012-stg-307760-surfpro","Controlling the Dimensionality of On-Surface Coordination Polymers via Endo- or Exoligation","Aneliia Shchyrba","The formation of on-surface coordination polymers is controlled by the interplay of chemical reactivity and structure of the building blocks, as well as by the orientating role of the substrate registry. Beyond the predetermined patterns of structural assembly, the chemical reactivity of the reactants involved may provide alternative pathways in their aggregation. Organic molecules, which are transformed in a surface reaction, may be subsequently trapped via coordination of homo- or heterometal ",{"id":514,"funder":7,"programme":8,"title":515,"piName":251,"institution":52,"country":53,"year":13,"amount":14,"abstract":516},"openalex-european-research-council-award-erc2011-stg-279520","Enantiomeric Adsorption of Lactic Acid Mixtures in Achiral Zeolites","We studied the adsorption of chiral mixtures of lactic acid in several zeolites. All zeolite systems showed either no selectivity or heteroselectivity in which the minority enantiomer is adsorbed by a higher fraction than its fraction in the reservoir. Analysis of the mechanism showed that none of the previously identified origins of enantioselective adsorption of scalemic mixtures apply to lactic acid. However, on the basis of the lack of any ordered distribution in the adsorbed phase, we postu",{"id":518,"funder":7,"programme":8,"title":519,"piName":520,"institution":521,"country":110,"year":13,"amount":14,"abstract":522},"openalex-european-research-council-award-grant-erc-2012-stg-310005-phasex","Tilted-grating approach for scanning-mode X-ray phase contrast imaging","Carolina Arboleda","Paul Scherrer Institute","Among the existent X-ray phase-contrast modalities, grating interferometry appears as a very promising technique for commercial applications, since it is compatible with conventional X-ray tubes and is robust from a mechanical point of view. However, since applications such as medical imaging and homeland security demand covering a considerable field of view, the fabrication of large-area gratings, which is known to be challenging and expensive, would be needed. A scanning setup is a good soluti",{"id":524,"funder":7,"programme":8,"title":525,"piName":526,"institution":14,"country":14,"year":13,"amount":14,"abstract":527},"openalex-european-research-council-award-erc-stg-283404-to-nw","The role of alpha oscillations for illusory perception","Joachim Lange","Alpha oscillations are a prominent electrophysiological signal measured across a wide range of species and cortical and subcortical sites. Alpha oscillations have been viewed for a long time as an \"idling\" rhythm, purely reflecting inactive sites. Despite earlier evidence from neurophysiology, awareness that alpha oscillations can substantially influence perception and behavior has grown only recently in cognitive neuroscience. Evidence for an active role of alpha for perception comes mainly fro",{"id":529,"funder":7,"programme":8,"title":530,"piName":531,"institution":532,"country":66,"year":13,"amount":14,"abstract":533},"openalex-european-research-council-award-erc-2010-stg-grant-agreement-no-259510-kismol","Dynamics of the α and β Polymorphs of \u003Cscp>dl\u003C\u002Fscp>-Norleucine at Different Temperatures: Sliding to a Partial Phase Transition","Joost A. van den Ende","Radboud University Nijmegen","The enantiotropically related α and β polymorphs of dl-norleucine are an interesting probe for polymorphism in molecular crystals. We present the results of quantitative molecular dynamics simulations of these two polymorphs at both stable and metastable temperatures. Because of a fully flexible force field, we can judge the differences in crystal and molecular properties between the polymorphs. In simulations of the β polymorph at 350 K, we observe partial phase transitions which we could follo",{"id":535,"funder":7,"programme":8,"title":536,"piName":537,"institution":84,"country":85,"year":13,"amount":14,"abstract":538},"openalex-european-research-council-award-erc-2007-stg-nr-203872-comosyel","Selection of Arginine-Rich Anti-Gold Antibodies Engineered for Plasmonic Colloid Self-Assembly","Purvi Jain","Antibodies are affinity proteins with a wide spectrum of applications in analytical and therapeutic biology. Proteins showing specific recognition for a chosen molecular target can be isolated and their encoding sequence identified in vitro from a large and diverse library by phage display selection. In this work, we show that this standard biochemical technique rapidly yields a collection of antibody protein binders for an inorganic target of major technological importance: crystalline metallic",{"id":540,"funder":7,"programme":8,"title":541,"piName":542,"institution":296,"country":21,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-ec-fp7-erc-stg-20101014","Corrigendum to: “The geochemistry of deep-sea coral skeletons: A review of vital effects and applications for palaeoceanography” [Deep-Sea Res. II 99 (2014) 184–198]","Laura F. Robinson",{"id":544,"funder":7,"programme":8,"title":545,"piName":546,"institution":547,"country":28,"year":13,"amount":14,"abstract":548},"openalex-european-research-council-award-erc-2009-stg-240910-rometa","Editorial","Xiaohong Chen","Yale University","Most of these papers were presented at a Conference in Honour of Joel's 70th birthday held in June 2011 at University College London. Joel has made influential contributions to many areas in econometrics and statistics. These include bootstrap methods, semi-parametric and nonparametric estimation, specification testing, non-parametric instrumental variables, estimation of high-dimensional models, and functional data analysis, among others. The six papers that appear in this Special Issue are rel",{"id":550,"funder":7,"programme":8,"title":551,"piName":552,"institution":553,"country":66,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-stg-309495-neonano","Liposomal corticosteroids for the treatment of inflammatory disorders and cancer","Gert Storm","University of Twente",{"id":555,"funder":7,"programme":8,"title":556,"piName":557,"institution":558,"country":53,"year":13,"amount":14,"abstract":559},"openalex-european-research-council-award-erc-2007-stg-210355","Two-Photon Neuronal and Astrocytic Stimulation with Azobenzene-Based Photoswitches","Mercè Izquierdo-Serra","Institute for Bioengineering of Catalonia","Synthetic photochromic compounds can be designed to control a variety of proteins and their biochemical functions in living cells, but the high spatiotemporal precision and tissue penetration of two-photon stimulation have never been investigated in these molecules. Here we demonstrate two-photon excitation of azobenzene-based protein switches and versatile strategies to enhance their photochemical responses. This enables new applications to control the activation of neurons and astrocytes with ",{"id":561,"funder":7,"programme":8,"title":562,"piName":563,"institution":416,"country":201,"year":13,"amount":14,"abstract":564},"openalex-european-research-council-award-erc-2011-stg-no-278698-precise-nano-","Self-Assembly and Orbital Imaging of Metal Phthalocyanines on a Graphene Model Surface","Päivi Järvinen","Metal phthalocyanines (MPc) form a tunable class of molecules, where both the central metal ion and the organic macrocycle can be modified. This allows the electronic properties and self-assembly of these molecules to be tuned over a broad range. We focus on cobalt phthalocyanine (CoPc), copper phthalocyanine (CuPc), and fully fluorinated cobalt phthalocyanine (F16CoPc) and study their self-assembly on epitaxial graphene. We investigate the energetic positions and symmetries of the frontier mole",{"id":566,"funder":7,"programme":8,"title":567,"piName":568,"institution":569,"country":21,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-2007-stg-203143","Online learning and fusion of orientation appearance models for robust rigid object tracking","Ioannis Marras","Imperial College London",{"id":571,"funder":7,"programme":8,"title":572,"piName":573,"institution":574,"country":110,"year":13,"amount":14,"abstract":575},"openalex-european-research-council-award-stg-207419","Characterization of Phosphorylation- and RNA-Dependent UPF1 Interactors by Quantitative Proteomics","Valentin Flury","University of Bern","Human up-frameshift 1 (UPF1) is an ATP-dependent RNA helicase and phosphoprotein implicated in several biological processes but is best known for its key function in nonsense-mediated mRNA decay (NMD). Here we employed a combination of stable isotope labeling of amino acids in cell culture experiments to determine by quantitative proteomics UPF1 interactors. We used this approach to distinguish between RNA-mediated and protein-mediated UPF1 interactors and to determine proteins that preferential",{"id":577,"funder":7,"programme":8,"title":578,"piName":579,"institution":580,"country":581,"year":13,"amount":14,"abstract":582},"openalex-european-research-council-award-stg-241426","Improving industrial yeast strains: exploiting natural and artificial diversity","Jan Steensels","KU Leuven","BE","Yeasts have been used for thousands of years to make fermented foods and beverages, such as beer, wine, sake, and bread. However, the choice for a particular yeast strain or species for a specific industrial application is often based on historical, rather than scientific grounds. Moreover, new biotechnological yeast applications, such as the production of second-generation biofuels, confront yeast with environments and challenges that differ from those encountered in traditional food fermentati",{"id":584,"funder":7,"programme":8,"title":585,"piName":586,"institution":302,"country":21,"year":13,"amount":14,"abstract":587},"openalex-european-research-council-award-erc-2012-stg-310987","Bacterial autolysins trim cell surface peptidoglycan to prevent detection by the Drosophila innate immune system","Magda L. Atilano","Bacteria have to avoid recognition by the host immune system in order to establish a successful infection. Peptidoglycan, the principal constituent of virtually all bacterial surfaces, is a specific molecular signature recognized by dedicated host receptors, present in animals and plants, which trigger an immune response. Here we report that autolysins from Gram-positive pathogenic bacteria, enzymes capable of hydrolyzing peptidoglycan, have a major role in concealing this inflammatory molecule ",{"id":589,"funder":7,"programme":8,"title":590,"piName":591,"institution":592,"country":455,"year":13,"amount":14,"abstract":593},"openalex-european-research-council-award-stg-260395","Peroxisomes are juxtaposed to strategic sites on mitochondria","Yael Elbaz‐Alon","Melodea (Israel)","Peroxisomes are ubiquitous and dynamic organelles that house many important pathways of cellular metabolism. In recent years it has been demonstrated that mitochondria are tightly connected with peroxisomes and are defective in several peroxisomal diseases. Indeed, these two organelles share metabolic routes as well as resident proteins and, at least in mammals, are connected via a vesicular transport pathway. However the exact extent of cross-talk between peroxisomes and mitochondria remains un",{"id":595,"funder":7,"programme":8,"title":596,"piName":597,"institution":14,"country":14,"year":13,"amount":14,"abstract":598},"openalex-european-research-council-award-stg-260809","Cytosine DNA Methylation Is Found in \u003Ci>Drosophila melanogaster\u003C\u002Fi> but Absent in \u003Ci>Saccharomyces cerevisiae, Schizosaccharomyces pombe\u003C\u002Fi>, and Other Yeast Species","Floriana Capuano","The methylation of cytosine to 5-methylcytosine (5-meC) is an important epigenetic DNA modification in many bacteria, plants, and mammals, but its relevance for important model organisms, including Caenorhabditis elegans and Drosophila melanogaster, is still equivocal. By reporting the presence of 5-meC in a broad variety of wild, laboratory, and industrial yeasts, a recent study also challenged the dogma about the absence of DNA methylation in yeast species. We would like to bring to attention ",{"id":600,"funder":7,"programme":8,"title":601,"piName":602,"institution":603,"country":182,"year":13,"amount":14,"abstract":604},"openalex-european-research-council-award-erc-sg-ls1-erc-starting-grant","Simultaneous dual-color 3D STED microscopy","Christian Osseforth","Universität Ulm","We describe the design and implementation of a stimulated emission depletion (STED) microscope which allows simultaneous three-dimensional super-resolution imaging in two colors. A super-continuum laser source is used to provide all spectral bands necessary for excitation and efficient depletion to achieve a lateral and axial resolution of ~35 nm and ~90 nm respectively. We characterize the systems' performance by imaging colloidal particles and single fluorescent molecules. Its biological appli",{"id":606,"funder":7,"programme":8,"title":607,"piName":608,"institution":609,"country":110,"year":13,"amount":14,"abstract":610},"openalex-european-research-council-award-erc-2009-stg-243344-neurochems","Long term functional plasticity of sensory inputs mediated by olfactory learning","Nixon M. Abraham","University of Geneva","Sensory inputs are remarkably organized along all sensory pathways. While sensory representations are known to undergo plasticity at the higher levels of sensory pathways following peripheral lesions or sensory experience, less is known about the functional plasticity of peripheral inputs induced by learning. We addressed this question in the adult mouse olfactory system by combining odor discrimination studies with functional imaging of sensory input activity in awake mice. Here we show that as",{"id":612,"funder":7,"programme":8,"title":613,"piName":614,"institution":615,"country":616,"year":13,"amount":14,"abstract":14},"openalex-european-research-council-award-erc-stg-2012-307207","Controlling anonymous mobile agents with unidirectional locomotion to form formations on a circle","Chen Wang","Peking University","CN",{"id":618,"funder":7,"programme":8,"title":619,"piName":620,"institution":621,"country":28,"year":13,"amount":14,"abstract":622},"openalex-european-research-council-award-erc-2011-stg-280135-animetrics","Fracture animation based on high-dimensional Voronoi diagrams","Sara C. Schvartzman","Stanford University","We propose a novel algorithm to simulate brittle fracture. It augments previous methods based on Voronoi diagrams, improving their versatility and their ability to adapt fracture patterns automatically to diverse collision scenarios and object properties. We cast brittle fracture as the computation of a high-dimensional Centroidal Voronoi Diagram (CVD), where the distribution of fracture fragments is guided by the deformation field of the fractured object. By formulating the problem in high dime",{"id":624,"funder":7,"programme":8,"title":625,"piName":626,"institution":175,"country":53,"year":13,"amount":14,"abstract":627},"openalex-european-research-council-award-erc-2012-stg-306751","Nonlinear finite element simulations of injuries with free boundaries: Application to surgical wounds","Clara Valero","Wound healing is a process driven by biochemical and mechanical variables in which a new tissue is synthesised to recover original tissue functionality. Wound morphology plays a crucial role in this process, as the skin behaviour is not uniform along different directions. In this work, we simulate the contraction of surgical wounds, which can be characterised as elongated and deep wounds. Because of the regularity of this morphology, we approximate the evolution of the wound through its cross se",{"id":629,"funder":7,"programme":8,"title":630,"piName":631,"institution":632,"country":182,"year":13,"amount":14,"abstract":633},"openalex-european-research-council-award-erc-starting-grant-309495-neonano-","Passive versus Active Tumor Targeting Using RGD- and NGR-Modified Polymeric Nanomedicines","Sijumon Kunjachan","RWTH Aachen University","Enhanced permeability and retention (EPR) and the (over-) expression of angiogenesis-related surface receptors are key features of tumor blood vessels. As a consequence, EPR-mediated passive and Arg-Gly-Asp (RGD) and Asn-Gly-Arg (NGR) based active tumor targeting have received considerable attention in the last couple of years. Using several different in vivo and ex vivo optical imaging techniques, we here visualized and quantified the benefit of RGD- and NGR-based vascular vs EPR-mediated passi",{"id":635,"funder":7,"programme":8,"title":636,"piName":637,"institution":638,"country":148,"year":13,"amount":14,"abstract":639},"openalex-european-research-council-award-erc-stg-atmogain-grant-no-278277","Succinic acid in aqueous solution: connecting microscopic surface composition and macroscopic surface tension","Josephina Werner","Uppsala University","The water-vapor interface of aqueous solutions of succinic acid, where pH values and bulk concentrations were varied, has been studied using surface sensitive X-ray photoelectron spectroscopy (XPS) and molecular dynamics (MD) simulations. It was found that succinic acid has a considerably higher propensity to reside in the aqueous surface region than its deprotonated form, which is effectively depleted from the surface due to the two strongly hydrated carboxylate groups. From both XPS experiment",{"id":641,"funder":7,"programme":8,"title":642,"piName":643,"institution":644,"country":182,"year":13,"amount":14,"abstract":645},"openalex-european-research-council-award-erc-stg-stg-338258-optoqmol-","The emergence of complex behaviours in molecular magnetic materials","Lapo Bogani","University of Stuttgart","Molecular magnetism is considered an area where magnetic phenomena that are usually difficult to demonstrate can emerge with particular clarity. Over the years, however, less understandable systems have appeared in the literature of molecular magnetic materials, in some cases showing features that hint at the spontaneous emergence of global structures out of local interactions. This ingredient is typical of a wider class of problems, called complex behaviours, where the theory of complexity is c",{"id":647,"funder":7,"programme":8,"title":648,"piName":649,"institution":650,"country":651,"year":13,"amount":14,"abstract":652},"openalex-european-research-council-award-erc-2010-stg-257032-microbone","Micro-poro-elasticity of baghdadite-based bone tissue engineering scaffolds: A unifying approach based on ultrasonics, nanoindentation, and homogenization theory","Christian Hellmich","TU Wien","AT","Microstructure-elasticity relations for bone tissue engineering scaffolds are key to rational biomaterial design. As a contribution thereto, we here report comprehensive length measuring, weighing, and ultrasonic tests at 0.1MHz frequency, on porous baghdadite (Ca3ZrSi2O9) scaffolds. The resulting porosity-stiffness relations further confirm a formerly detected, micromechanically explained, general relationship for a great variety of different polycrystals, which also allows for estimating the z",{"id":654,"funder":7,"programme":8,"title":655,"piName":656,"institution":218,"country":182,"year":13,"amount":14,"abstract":657},"openalex-european-research-council-award-erc-2007-stg-208162","Magnetoresistance and Charge Transport in Graphene Governed by Nitrogen Dopants","Markus Rein","We identify the influence of nitrogen-doping on charge- and magnetotransport of single layer graphene by comparing doped and undoped samples. Both sample types are grown by chemical vapor deposition (CVD) and transferred in an identical process onto Si\u002FSiO2 wafers. We characterize the samples by Raman spectroscopy as well as by variable temperature magnetotransport measurements. Over the entire temperature range, the charge transport properties of all undoped samples are in line with literature ",{"id":659,"funder":7,"programme":8,"title":660,"piName":661,"institution":240,"country":182,"year":13,"amount":14,"abstract":662},"openalex-european-research-council-award-fp7-stg-240142","Regularized iterative integration combined with non-linear diffusion filtering for phase-contrast x-ray computed tomography","Karin Burger","Phase-contrast x-ray computed tomography has a high potential to become clinically implemented because of its complementarity to conventional absorption-contrast.In this study, we investigate noise-reducing but resolution-preserving analytical reconstruction methods to improve differential phase-contrast imaging. We apply the non-linear Perona-Malik filter on phase-contrast data prior or post filtered backprojected reconstruction. Secondly, the Hilbert kernel is replaced by regularized iterative",{"id":664,"funder":7,"programme":8,"title":665,"piName":666,"institution":667,"country":443,"year":13,"amount":14,"abstract":668},"openalex-european-research-council-award-239685-collregen-erc-2009-stg","Incorporation of polymeric microparticles into collagen-hydroxyapatite scaffolds for the delivery of a pro-osteogenic peptide for bone tissue engineering","Adolfo López‐Noriega","Advanced Materials and BioEngineering Research","Collagen-hydroxyapatite scaffolds are outstanding materials for bone tissue engineering as they are biocompatible, bioresorbable, osteoconductive, and osteoinductive. The objective of the present work was to assess the potential of increasing their regenerative capacity by functionalising the scaffolds for therapeutic delivery. This was achieved by the utilization of polymeric drug carriers. With this purpose, alginate, chitosan, gelatine, and poly(lactic-co-glycolic acid) (PLGA) microparticles ",{"id":670,"funder":7,"programme":8,"title":671,"piName":672,"institution":14,"country":14,"year":13,"amount":14,"abstract":673},"openalex-european-research-council-award-stg-260572","Synthesis and characterization of the anticancer and metal binding properties of novel pyrimidinylhydrazone derivatives","Éva A. Enyedy","Three novel pyrimidinylhydrazones substituted at either the aromatic moiety or at the imine carbon atom were synthesized and characterized by standard analytical methods. All compounds were found to be toxic in the micro- to submicromolar range against a diverse panel of cancer cell lines including multidrug resistant (MDR) derivatives expressing P-glycoprotein (Pgp). UV-visible spectrophotometry experiments demonstrated that the most active compound (3) forms highly stable complexes with iron(I",{"id":675,"funder":7,"programme":8,"title":676,"piName":14,"institution":677,"country":85,"year":13,"amount":678,"abstract":679},"cordis-european-research-council-award-337665","Parsimony and operator methods for treatment of endogeneity and multiple sources of unobserved heterogeneity","FONDATION JEAN JACQUES LAFFONT,TOULOUSE SCIENCES ECONOMIQUES","€911,388","Unobserved heterogeneity and endogeneity are prevalent notions throughout econometrics. Most of the literature focuses on scalar unobserved heterogeneity. It implies strong restrictions on the heterogeneity of the behaviour of economic agents. This is the case in a binary treatment effect model where scalar unobserved heterogeneity and additive separability of the index in the selection equation are equivalent to the restrictive monotonicity assumption. Nonparametric random coefficients models a",{"id":681,"funder":7,"programme":8,"title":682,"piName":14,"institution":683,"country":12,"year":13,"amount":684,"abstract":685},"cordis-european-research-council-award-336155","The role of consumer behavior and heterogeneity in the integrated assessment of energy and climate policies","POLITECNICO DI MILANO","€1,451,840","The objective of this project is to quantify the role of consumers’ behaviour on the design and assessment of policies aimed at enhancing energy efficiency and conservation and at promoting climate change mitigation. The project brings together different disciplines –namely energy policy, environmental and ecological economics, behavioral public finance, experimental economics, and technology policy- in an integrated fashion. COBHAM is designed to go beyond the standard analysis of energy and cl",{"id":687,"funder":7,"programme":8,"title":688,"piName":14,"institution":689,"country":182,"year":13,"amount":690,"abstract":691},"cordis-european-research-council-award-338041","Optogenetic dissection of motor cortex dynamics and pathways","ALBERT-LUDWIGS-UNIVERSITAET FREIBURG","€1,498,890","Within a densely interconnected network, selective communication can be achieved only if neuronal inputs and outputs are functionally segmented and if only one segment is selected for a given time and neural population. We focus here on this process in the primary motor cortex (M1) which projects to a variety of brain structures involved in motor generation and suppression as well as somatosensory perception. We propose to investigate what kind of information is sent to two of M1’s main target b",{"id":693,"funder":7,"programme":8,"title":694,"piName":14,"institution":695,"country":110,"year":13,"amount":696,"abstract":697},"cordis-european-research-council-award-335989","Chaos in Parabolic Dynamics: Mixing, Rigidity, Spectra","UNIVERSITAT ZURICH","€1,193,534","The theme of the proposal is the mathematical investigation of chaos (in particular ergodic and spectral properties) in parabolic dynamics, via analytic, geometric and probabilistic techniques. Parabolic dynamical systems are mathematical models of the many phenomena which display a slow form of chaotic evolution, in the sense that nearby trajectories diverge polynomially in time.  In contrast with the hyperbolic case and with the elliptic case, there is no general theory which describes parabol",{"id":699,"funder":7,"programme":8,"title":700,"piName":14,"institution":701,"country":110,"year":13,"amount":702,"abstract":703},"cordis-european-research-council-award-337965","Unraveling the cellular responses to aberrantly-folded and aggregated proteins","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","€1,500,000","Protein aggregation diseases are associated with the intracellular accumulation of specific misfolded protein aggregates, that are directly implicated in cellular dysfunction. A range of human disorders of previously unknown nature now falls into this category. The mechanisms of aggregation-induced cell degeneration are however unclear, resulting in poor therapeutic strategies. In this project we will characterize the network of cellular responses to a set of disease-related aggregation-prone pr",{"id":705,"funder":7,"programme":8,"title":706,"piName":14,"institution":701,"country":110,"year":13,"amount":707,"abstract":708},"cordis-european-research-council-award-337906","From Isolated Compartments to Intracellular Networks: Deciphering Interorganelle Communication","€1,494,503","Organelles exchange metabolites and information to coordinate essential aspects of cellular physiology, thus behaving as an integrated intracellular network. For example, the endoplasmic reticulum (ER) makes contacts with several organelles, including the plasma membrane, mitochondria, the Golgi apparatus, and lysosomes. These contacts allow the coordination of calcium and lipid homeostasis across the cell. Yet, little is known about their molecular nature. A long-standing question in cell biolo",{"id":710,"funder":7,"programme":8,"title":711,"piName":14,"institution":701,"country":110,"year":13,"amount":712,"abstract":713},"cordis-european-research-council-award-335529","New phylogenetic methods for inferring complex population dynamics","€1,471,582","The field of phylogenetics is undergoing an important change over recent time. For a long time phylogenetics focussed on describing the species tree as accurate as possible. More recently there is a shift towards a functional inference of the evolutionary process itself, i.e. researchers attempt to infer what processes are most likely responsible for the particular pattern of branching observed in a given phylogeny.Phylogenetics has traditionally been developed for macroevolution. Recently, it h",{"id":715,"funder":7,"programme":8,"title":716,"piName":14,"institution":717,"country":182,"year":13,"amount":718,"abstract":719},"cordis-european-research-council-award-337654","Control based on Human Models","TECHNISCHE UNIVERSITAET MUENCHEN","€1,494,640","CON-HUMO focuses on novel concepts for automatic control based on data-driven human models and machine learning. This enables innovative control applications that are difficult if not impossible to realize using traditional control and identification methods, in particular in the challenging area of smart human-machine interaction. In order to achieve intuitive and efficient goal-oriented interaction, anticipation is key. For control selection based on prediction a dynamic model of the human int",{"id":721,"funder":7,"programme":8,"title":722,"piName":14,"institution":723,"country":182,"year":13,"amount":724,"abstract":725},"cordis-european-research-council-award-338164","Intelligent systems' Holistic Evolving Analysis of Real-life Universal speaker characteristics","UNIVERSITAT PASSAU","€1,498,200","Recently, automatic speech and speaker recognition has matured to the degree that it entered the daily lives of thousands of Europe's citizens, e.g., on their smart phones or in call services. During the next years, speech processing technology will move to a new level of social awareness to make interaction more intuitive, speech retrieval more efficient, and lend additional competence to computer-mediated communication and speech-analysis services in the commercial, health, security, and furth",{"id":727,"funder":7,"programme":8,"title":728,"piName":14,"institution":717,"country":182,"year":13,"amount":729,"abstract":730},"cordis-european-research-council-award-335623","In vitro reconstitution and mechanistic dissection of Intraflagellar Transport in C.elegans sensory cilia","€1,497,740","Cilia are microtubule-based protrusions of the plasma membrane found on many eukaryotic cells, including most cell types of the human body. Whereas the functions of motile cilia were immediately obvious, the role of the immotile or so-called primary cilia remained largely unrecognized for many decades. Once referred to as aberrant solitary cilia with no obvious function, these ancient structures now hold the promise of revealing no less than the secrets of multicellularity and development. Even ",{"id":732,"funder":7,"programme":8,"title":733,"piName":14,"institution":734,"country":66,"year":13,"amount":702,"abstract":735},"cordis-european-research-council-award-336291","Sorting out Polarized Transport in Neurons: Motor Protein Selectivity and Cooperativity","UNIVERSITEIT UTRECHT","Neurons are the building blocks of the brain. The ability of neurons to receive, process and transmit information depends on their polarized organization into axons and dendrites. To build such a highly polarized cell, cellular components synthesized in the cell body are differentially transported to either axons or dendrites. Polarized transport is driven by three families of cytoskeletal motor proteins, which can walk in different directions over the actin or microtubule cytoskeleton. Many sub",{"id":737,"funder":7,"programme":8,"title":738,"piName":14,"institution":739,"country":581,"year":13,"amount":740,"abstract":741},"cordis-european-research-council-award-336608","Neither visitors, nor colonial victims: Muslims in Interwar Europe and European Trans-cultural History","KATHOLIEKE UNIVERSITEIT LEUVEN","€1,498,984","No comprehensive attempt has yet been made to cover the history of Muslims in interwar Europe. Historians of the modern Middle East underestimate the role of interwar Muslim actors in writing a history of Islam, whereas historians of Europe underestimate their role in intra-European developments. Existing works focus either on the nineteenth-century Muslim travelers, diplomats, students and residents or on the later post-World War II influx of Muslim immigrant workers.Based on personal and offic",{"id":743,"funder":7,"programme":8,"title":744,"piName":14,"institution":745,"country":455,"year":13,"amount":746,"abstract":747},"cordis-european-research-council-award-337637","Optical dissection of prefrontal neuromodulation: from synapses through networks to behavior","WEIZMANN INSTITUTE OF SCIENCE","€1,429,460","The neocortex is organized into neural circuits that perform distinct computations, from sensory processing and motor control to memory, learning and language. Neuromodulatory systems projecting to the neocortex exert a powerful influence on cortical computations through neurotransmitters such as acetylcholine, monoamines and neuropeptides. The prefrontal cortex (PFC), a cortical region required for working memory, attention and goal-directed behavior, receives dense projections from multiple ne",{"id":749,"funder":7,"programme":8,"title":750,"piName":14,"institution":751,"country":110,"year":13,"amount":752,"abstract":753},"cordis-european-research-council-award-335809","Interplay between influenza viruses and host SUMO pathways","University of Zurich","€1,482,452","Influenza viruses cause a significant seasonal disease burden and continually threaten to initiate human pandemics. Antivirals are available for treatment of influenza, however drug-resistant viruses often emerge. Thus, there is urgent need to develop new antivirals with lower chances of selecting resistance. As viruses rely extensively on cellular functions, one way to minimise resistance is to target new antivirals against host factors. This concept requires a fundamental understanding of mech",{"id":755,"funder":7,"programme":8,"title":756,"piName":14,"institution":757,"country":66,"year":13,"amount":758,"abstract":759},"cordis-european-research-council-award-336454","Clinical ultrasound platform for the quantitative and longitudinal imaging of theranostics and cellular therapy","STICHTING RADBOUD UNIVERSITEIT","€1,199,882","The success of modern medical treatments such as cellular therapy and targeted treatments requires appropriate tools for in vivo monitoring. Imaging modalities, such as magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT) and positron emission tomography (PET) are key candidates due to their noninvasive nature. However, these imaging techniques are extremely expensive and can involve radiation, both of which hinder their longitudinal and repetitive use.Ultrasound ",{"id":761,"funder":7,"programme":8,"title":762,"piName":14,"institution":763,"country":53,"year":13,"amount":764,"abstract":765},"cordis-european-research-council-award-335568","Architecture of bacterial lipid rafts; inhibition of virulence and antibiotic resistance using raft-disassembling small molecules","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","€1,493,126","Membranes of eukaryotic cells organize signal transduction proteins into microdomains or lipid rafts whose integrity is essential for numerous cellular processes. Lipid rafts has been considered a fundamental step to define the cellular complexity of eukaryotes, assuming that bacteria do not require such a sophisticated organization of their signaling networks. However, I have discovered that bacteria organize many signaling pathways in membrane microdomains similar to the eukaryotic lipid rafts",{"id":767,"funder":7,"programme":8,"title":768,"piName":14,"institution":769,"country":182,"year":13,"amount":770,"abstract":771},"cordis-european-research-council-award-336305","Mechanisms of social attention","JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG","€1,379,710","A fundamental research question of several disciplines concerns the description, explanation and prediction of human behavior in social contexts. While significant research had been devoted to higher order social capabilities, much less is known about basic principles that are underlying these functions. This is especially true for social attention which is at the heart of every higher order social function but has neither been systematically examined in naturalistic environments before nor has ",{"id":773,"funder":7,"programme":8,"title":774,"piName":14,"institution":775,"country":776,"year":13,"amount":777,"abstract":778},"cordis-european-research-council-award-336839","Re-engineering the tumor microenvironment to alleviate mechanical stresses and improve chemotherapy","UNIVERSITY OF CYPRUS","CY","€1,440,360","Current chemotherapeutic agents are potent enough to kill cancer cells. Nonetheless, failure of chemotherapies for many cancers (e.g. breast and pancreatic cancers and various sarcomas) is primarily because these agents cannot reach cancer cells in amounts sufficient to cause complete cure. The abnormal microenvironment of these tumors drastically reduces perfusion and results in insufficient delivery of therapeutic agents. Tumor structural abnormalities is in large part an effect of mechanical ",{"id":780,"funder":7,"programme":8,"title":781,"piName":14,"institution":782,"country":651,"year":13,"amount":783,"abstract":784},"cordis-european-research-council-award-336679","Fundamentals Of Photocatalytic Splitting of Water","UNIVERSITAT WIEN","€1,498,800","Hydrogen produced by sunlight is a very promising, environmentally-friendly energy source as an alternative for increasingly scarce and polluting fossil fuels. Since the discovery of hydrogen production by photocatalytic water dissociation on a titanium dioxide (TiO2) electrode 40 years ago, much research has been aimed at increasing the process efficiency. Remarkably, insights into how water is bound to the catalyst and into the dynamics of the photodissociation reaction, have been scarce up to",{"id":786,"funder":7,"programme":8,"title":787,"piName":14,"institution":782,"country":651,"year":13,"amount":702,"abstract":788},"cordis-european-research-council-award-337011","Molecular neurobiology of a moonlight entrained circalunar clock","Numerous scientific studies have established that the lunar cycle synchronizes reproductive behaviour and sexual maturation of animals as diverse as corals, polychaetes and fishes. Classical and recent work shows that in animals such as the annelid Platynereis dumerilii, dim nocturnal light serves as entrainment cue for an endogenous oscillator – a circalunar clock – that orchestrates reproductive and behavioral cycles. As circalunar clocks run with a (semi-)monthly period, they represent a fund",{"id":790,"funder":7,"programme":8,"title":791,"piName":14,"institution":739,"country":581,"year":13,"amount":792,"abstract":793},"cordis-european-research-council-award-334946","Ribosome defects in cancer","€1,497,038","Cancer cells are defective in vital cell functions such as cell cycle control and response to growth signals. We found that cancer cells acquire defects in yet another vital function: translation of mRNA into proteins. We saw that 9.8% of children with T-cell leukemia (T-ALL) harbor acquired mutations in the ribosome, the cellular protein translation factory. We found mutations in RPL10, RPL5 and RPL22, 3 proteins of the large 60S ribosomal subunit. Strikingly, 6.5% of T-ALL patients had the sam",{"id":795,"funder":7,"programme":8,"title":796,"piName":14,"institution":763,"country":53,"year":13,"amount":14,"abstract":797},"cordis-european-research-council-award-335079","Invariant manifolds in dynamical systems and PDE","The goal of this project is to develop new techniques combining tools from dynamical systems, analysis and differential geometry to study the existence and properties of invariant manifolds arising from solutions to differential equations. These structures are relevant in the study of the qualitative properties of ODE and PDE and appear very naturally in important questions of mathematical physics. This proposal can be divided in three blocks: the study of periodic orbits and related dynamical s",{"id":799,"funder":7,"programme":8,"title":800,"piName":14,"institution":801,"country":110,"year":13,"amount":702,"abstract":802},"cordis-european-research-council-award-335333","Mapping the synaptic circuits for salience","UNIVERSITE DE LAUSANNE","An unpredicted salient event – rewarding or aversive – triggers a rapid emotional reaction that has profound impact in making a future choice. The early neurobiological processes behind it are matter of intense study. However, the hierarchical anatomical and functional organization as well as the cellular mechanisms underlying acute perception of reward and aversive events remains unknown.  Intriguingly, salience experience alters the activity in the medial globus pallidus of the basal ganglia a",{"id":804,"funder":7,"programme":8,"title":805,"piName":14,"institution":806,"country":110,"year":13,"amount":807,"abstract":808},"cordis-european-research-council-award-338205","Modeling and controlling traffic congestion and propagation in large-scale urban multimodal networks","ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE","€1,242,162","As cities grow rapidly and more people through different modes compete for limited urban road infrastructure to travel, it is important to manage traffic space to improve accessibility for travelers. This project tackles the problem of modeling and optimization in large-scale congested traffic networks with an aggregated realistic representation of dynamics and route choice and multiple modes of transport. This is a highly motivating problem both because of the socio-economic influence of conges",{"id":810,"funder":7,"programme":8,"title":811,"piName":14,"institution":806,"country":110,"year":13,"amount":812,"abstract":813},"cordis-european-research-council-award-335288","Strong Convex Relaxations with Optimal Approximation Guarantees","€1,451,052","One of the most exciting areas of theoretical computer science is to understand the approximability of fundamental optimization problems. A prominent example is the traveling salesman problem, for which a long-standing conjecture states that a certain algorithm gives a better guarantee than current methods can prove. The resolution of this conjecture and of many other fundamental problems is intimately related to an increased understanding of strong convex relaxations.Although these problems hav",{"id":815,"funder":7,"programme":8,"title":816,"piName":14,"institution":817,"country":110,"year":13,"amount":818,"abstract":819},"cordis-european-research-council-award-337703","Novel insights into cardiac regeneration through studies in the zebrafish","UNIVERSITAET BERN","€1,499,215","Myocardial infarction (MI) leads to cardiomyocyte death and accumulation of myofibroblasts (MFs) at the site of injury, which produce large amounts of extracellular matrix (ECM), generating a scar. Initially, cardiac fibrosis protects from ventricular wall rupture, but subsequent myocardial remodelling causes heart failure, representing a leading cause of death in Europe. While MFs play a central role in cardiac fibrosis, there is confusion on their origin, a lack of specific markers and the exi",{"id":821,"funder":7,"programme":8,"title":822,"piName":14,"institution":823,"country":66,"year":13,"amount":824,"abstract":825},"cordis-european-research-council-award-335555","Lie Group Analysis for Medical Image Processing","TECHNISCHE UNIVERSITEIT EINDHOVEN","€1,267,550","The aim of this project is to substantially improve computer algorithms for image analysis in medical imaging. Currently available techniques often require significant application-specific tuning and have a limited application scope. This is mostly due to the use of non-generic feature spaces that involve many physical dimensions and lack mathematical foundation.Instead, we derive inspiration from the superior generic pattern recognition capabilities of the human brain and propose a novel operat",{"id":827,"funder":7,"programme":8,"title":828,"piName":14,"institution":829,"country":201,"year":13,"amount":702,"abstract":830},"cordis-european-research-council-award-336267","Development of 3D Histopathological Grading of Osteoarthritis","OULUN YLIOPISTO","Background: Osteoarthritis (OA) is a common musculoskeletal disease occurring worldwide. Despite extensive research, etiology of OA is still poorly understood. Histopathological grading (HPG) of 2D tissue sections is the gold standard reference method for determination of OA stage. However, traditional 2D-HPG is destructive and based only on subjective visual evaluation. These limitations induce bias to clinical in vitro OA diagnostics and basic research that both rely strongly on HPG.Objectives",{"id":832,"funder":7,"programme":8,"title":833,"piName":14,"institution":834,"country":148,"year":13,"amount":835,"abstract":836},"cordis-european-research-council-award-337069","The role of parvalbumin interneurons in cognition and behavior","KAROLINSKA INSTITUTET","€1,400,000","Cognition is a collective term for complex but sophisticated mental processes such as attention, learning, social interaction, language production, decision making and other executive functions. For normal brain function, these higher-order functions need to be aptly regulated and controlled, and the physiology and cellular substrates for cognitive functions are under intense investigation. The loss of cognitive control is intricately related to pathological states such as schizophrenia, depress",{"id":838,"funder":7,"programme":8,"title":839,"piName":14,"institution":840,"country":123,"year":13,"amount":14,"abstract":841},"cordis-european-research-council-award-335855","Structural studies of human picornaviruses","Masarykova univerzita","Many picornaviruses are human pathogens that cause diseases varying in symptoms from common cold to life-threatening encephalitis. Currently there are no anti-picornavirus drugs approved for human use. We propose to study molecular structures of picornaviruses and their life cycle intermediates in order to identify new targets for anti-viral inhibitors and to lay the foundations for structure-based development of drugs against previously structurally uncharacterized picornaviruses.We will use X-",{"id":843,"funder":7,"programme":8,"title":844,"piName":14,"institution":845,"country":182,"year":13,"amount":846,"abstract":847},"cordis-european-research-council-award-337567","analyse Soluble + Membrane complexes with Improved LILBID Experiments","JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN","€1,264,477","Crucial processes within cells depend on specific non-covalent interactions which mediate the assembly of proteins and other biomolecules. Deriving structural information to understand the function of these complex systems is the primary goal of Structural Biology.In this application, the recently developed LILBID method (Laser Induced Liquid Bead Ion Desorption) will be optimized for investigation of macromolecular complexes with a mass accuracy two orders of magnitude better than in 1st genera",{"id":849,"funder":7,"programme":8,"title":850,"piName":14,"institution":851,"country":852,"year":13,"amount":14,"abstract":853},"cordis-european-research-council-award-336665","Low-carbon Lifestyles and Behavioural Spillover","CARDIFF UNIVERSITY","UK","Responding to climate change has profound implications for behaviour; yet policies to achieve this change have met with limited success. A key challenge for environmental social scientists is the need to move forward in understanding how to bring about change in consumption, community and political behaviours, which is commensurate to the scale of the climate change challenge. One promising area is ‘behavioural spillover’, the notion that taking up a new behaviour (e.g., recycling) may lead to a",{"id":855,"funder":7,"programme":8,"title":856,"piName":14,"institution":857,"country":858,"year":13,"amount":859,"abstract":860},"cordis-european-research-council-award-335561","Function of Chemosensory Circuits","NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU","NO","€1,499,471","Smell and taste are the least studied of all senses. Very little is known about chemosensory information processing beyond the level of receptor neurons. Every morning we enjoy our coffee thanks to our brains ability to combine and process multiple sensory modalities. Meanwhile, we can still review a document on our desk by adjusting the weights of numerous sensory inputs that constantly bombard our brains. Yet, the smell of our coffee may remind us that pleasant weekend breakfast through associ",{"id":862,"funder":7,"programme":8,"title":863,"piName":14,"institution":864,"country":581,"year":13,"amount":865,"abstract":866},"cordis-european-research-council-award-337573","Mapping the Deprived Visual System: Cracking function for prediction","UNIVERSITE CATHOLIQUE DE LOUVAIN","€1,488,987","One of the most striking demonstrations of experience-dependent plasticity comes from studies of blind individuals showing that the occipital cortex (traditionally considered as purely visual) massively changes its functional tuning to support the processing of non-visual inputs. These mechanisms of crossmodal plasticity, classically considered compensatory, inevitably raise crucial challenges for sight-restoration. The neglected relation between crossmodal plasticity and sight-recovery will rep",{"id":868,"funder":7,"programme":8,"title":869,"piName":14,"institution":870,"country":66,"year":13,"amount":14,"abstract":871},"cordis-european-research-council-award-336540","Glioblastoma Inhibition: Targeting Tumour-derived Extracellular-Vesicle Driven Cell-Recruitment","STICHTING AMSTERDAM UMC","Glioblastomas (GBMs) are malignant brain tumours and among the most aggressive human cancers. GBMs patients have an extremely poor survival rate due to a complete absence of adequate therapies capable of efficiently targeting GBM cells inside the brain. Recently, we demonstrated that GBM cells release pro-tumoural extracellular vesicles (EVs) into the bloodstream, which emerged as important intermediates in communication with distant peripheral cells in the body. Of note, the distribution of GBM",{"id":873,"funder":7,"programme":8,"title":874,"piName":14,"institution":875,"country":66,"year":13,"amount":876,"abstract":877},"cordis-european-research-council-award-335260","Parton Distributions in the Higgs Boson Era","STICHTING VU","€1,330,502","With the recent discovery of a Higgs-like particle at the Large Hadron Collider (LHC), particle physics has entered a completely new era. The central goal for high energy physics in the following years will be the detailed determination of the properties of this new particle, in particular checking its consistency with the Standard Model Higgs boson hypothesis, and to further explore the highest energy domain in search for further new physics, like supersymmetry or extra dimensions, closely rela",{"id":879,"funder":7,"programme":8,"title":880,"piName":14,"institution":870,"country":66,"year":13,"amount":14,"abstract":881},"cordis-european-research-council-award-310884","Towards evidence-based genomic medicine: filling the evidence gaps through modelling studies","At increasingly high rate, genome-wide association and whole genome sequencing studies unravel genetic variants implicated in common diseases such as coronary heart disease, cancer, dementia and type 2 diabetes. One of the major promises is that these advances will lead to more personalized medicine, in which preventive and therapeutic interventions are targeted to individuals based on their genetic profiles.There is increasing interest in the early adoption of novel applications and many commer",{"id":883,"funder":7,"programme":8,"title":884,"piName":14,"institution":875,"country":66,"year":13,"amount":885,"abstract":886},"cordis-european-research-council-award-335542","The evolution of plant-fungal markets","€1,492,438","Throughout the Earth’s history, the mutualism between plants and their fungal partners has mediated nutrient cycles and energy flow in ecosystems. Underground, mycorrhizal fungi and plant roots form vast networks of connected individuals, in which sugars from roots are exchanged for nutrients from fungi.How is cooperation maintained in plant-fungal networks? Selfish individuals can potentially exploit the collaboration, reaping nutrient benefits while paying no costs. So, why cooperate at all?I ",{"id":888,"funder":7,"programme":8,"title":889,"piName":14,"institution":763,"country":53,"year":13,"amount":890,"abstract":891},"cordis-european-research-council-award-307496","Cold and wet early Mars: Proposing and testing a new theory to understand the early Martian environments","€1,411,200","Geologic evidence indicative of flowing and ponding liquid water on the surface of ancient Mars appears abundantly across most of the Martian landscape, indicating that liquid water was present in variable amounts and for long periods of time on and\u002For near the surface at different moments of Mars’ early history, the Noachian era. Early Mars appears to have been “wet”. However, the presence of liquid water on the surface of early Mars is difficult to reconcile with the reduced solar luminosity a",{"id":893,"funder":7,"programme":8,"title":894,"piName":14,"institution":895,"country":852,"year":13,"amount":896,"abstract":897},"cordis-european-research-council-award-335696","The Higgs: A colored View from the Top at ATLAS","THE UNIVERSITY OF MANCHESTER","€1,163,755","With the ground-breaking discovery of a new, Higgs-like boson on July 4th, 2012, by the CMS and ATLAS collaborations at CERN, a new era of particle physics has begun. The discovery is the first step in answering an unsolved problem in particle physics, the question how fundamental bosons and fermions acquire their mass. One of the major goals in collider physics in the next few years will be the deeper insight into the nature of the new particle, its connection to the known fundamental particles",{"id":899,"funder":7,"programme":8,"title":900,"piName":14,"institution":895,"country":852,"year":13,"amount":901,"abstract":902},"cordis-european-research-council-award-335905","Understanding the determinants of suicidal behaviour, serious accidents and violence in young people","€1,498,312","Direct comparisons of risk factor profiles for different forms of self-destructive, hazardous and violent behaviour in young people have rarely been made in the same study cohort. This maintains a possibly erroneous assumption that these behaviours have distinct aetiologies. These outcomes may represent different aspects of the same complex underlying aetiology, rather than being disjunctive phenomena. I shall collaborate with Professor Preben Mortensen and colleagues at the world renowned Natio",{"id":904,"funder":7,"programme":8,"title":905,"piName":14,"institution":906,"country":12,"year":13,"amount":14,"abstract":907},"cordis-european-research-council-award-335359","Cryogenic wide-Area Light Detectors \u2028with Excellent Resolution","ISTITUTO NAZIONALE DI FISICA NUCLEARE","In the comprehension of fundamental laws of nature, particle physics is now facing two important questions:1) What is the nature of the neutrino, is it a standard (Dirac) particle or a Majorana particle? The nature of the neutrino plays a crucial role in the global framework of particle interactions and in cosmology. The only practicable way to answer this question is to search for a nuclear process called neutrinoless double beta decay (0nuDBD).2) What is the so called dark matter made of? Astr",{"id":909,"funder":7,"programme":8,"title":910,"piName":14,"institution":911,"country":182,"year":13,"amount":912,"abstract":913},"cordis-european-research-council-award-336536","What is the engine of biodiversity? Comparative and Functional Speciation Genetics in the Post-genomic Era","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€1,494,300","More than 150 years after the seminal works of Charles Darwin on speciation, we are beginning to unravel the genetic underpinnings of the splitting process (Ellegren H [..] JBW Wolf, Nature, in press). The genomic revolution is progressing at full speed, and for the first time in history we are equipped with the necessary tools to investigate the genomic architecture of speciation at base-pair resolution in any organisms of our choice. When integrated to the mature theoretical framework of the e",{"id":915,"funder":7,"programme":8,"title":916,"piName":14,"institution":917,"country":148,"year":13,"amount":918,"abstract":919},"cordis-european-research-council-award-335395","Cardiomics: Use of -omics methods in large populations for identification of novel drug targets and clinical biomarkers for coronary heart disease","UPPSALA UNIVERSITET","€1,498,224","There is a large need for revitalization of the research on coronary heart disease (CHD) including: a) improved risk prediction and more adequate individually-tailored treatment; and b) new targets for drug development based on pathways previously unknown to be involved in CHD pathophysiology.The overall goal of this proposal is to improve prevention and treatment of CHD through better understanding of the biology underlying disease development, identification of new biomarkers for improved risk",{"id":921,"funder":7,"programme":8,"title":922,"piName":14,"institution":923,"country":85,"year":13,"amount":702,"abstract":924},"cordis-european-research-council-award-336629","Role of the transcription factor ChREBP and its associated proteins in the development and progression of NAFLD.","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","Changes in lifestyle have resulted in a dramatic epidemic of type 2 diabetes and obesity. Among associated complications, Nonalcoholic Fatty Liver Disease (NAFLD) is emerging as the most common chronic liver disease and is gaining increasing recognition as a component of the epidemic of obesity. NAFLD is generally asymptomatic, although a minority of patients may present progressive liver injury with complications of Nonalcoholic steatohepatitis (NASH), cirrhosis and HCC. Excessive accumulation ",{"id":926,"funder":7,"programme":8,"title":927,"piName":14,"institution":923,"country":85,"year":13,"amount":14,"abstract":928},"cordis-european-research-council-award-338141","An intracellular approach to spatial coding in the hippocampus","The hippocampus is an important structure for spatial memory in rodents and episodic memory in humans. The hippocampus uses a sparse coding scheme where a given environment is represented by the place selective firing of a small group of cells, (called place cells) among a larger population of silent neurons. Thus a given environment is not only coded by the firing rate and timing of active cells but also by the very identity of these cells that fire or stay silent in that environment. Similarly",{"id":930,"funder":7,"programme":8,"title":931,"piName":14,"institution":932,"country":581,"year":13,"amount":933,"abstract":934},"cordis-european-research-council-award-336480","SPECULOOS: searching for habitable planets amenable for biosignatures detection around the nearest ultra-cool stars","UNIVERSITE DE LIEGE","€1,963,990","One of the most significant goals of modern astronomy  is establishing whether life exists around other stars. The most direct path towards its achievement is the detection and spectroscopic characterization of terrestrial planets orbiting in the habitable zone of their host stars. The ~1000 nearest ultra-cool stars (UCS, spectral type M6 and latter) represent a unique opportunity to reach this goal within the next decade. Due to their small luminosity, their habitable zone is 30-100 times close",{"id":936,"funder":7,"programme":8,"title":937,"piName":14,"institution":938,"country":85,"year":13,"amount":939,"abstract":940},"cordis-european-research-council-award-337591","Exoplanets in Transit and their Atmosphere","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€2,000,000","Since the discoveries of giant planets outside our Solar System, over 800 extra-solar planets have been detected and several thousands candidates are awaiting confirmation. They have revolutionized planetary science, by placing our once unique solar system into context. The subset of extrasolar planets that transit their parent star have had most impact on our understanding of their planetary structure and atmospheric physics: they are the only ones for which one can simultaneously measure mass ",{"id":942,"funder":7,"programme":8,"title":943,"piName":14,"institution":938,"country":85,"year":13,"amount":944,"abstract":945},"cordis-european-research-council-award-335536","Cracking the emotional code of music","€1,499,992","This project aims to crack the emotional code of music, i.e. to provide, for the first time, a precise characterization of what type of music signal is able to activate one emotion or another. Research into this problem so far has been mainly correlating indistinct emotional reactions to uncontrolled musical stimuli, with much technical sophistication but to little avail. Project CREAM builds on the PI's unique bi-disciplinary career spanning both computer science and cognitive neuroscience, to ",{"id":947,"funder":7,"programme":8,"title":948,"piName":14,"institution":938,"country":85,"year":13,"amount":949,"abstract":950},"cordis-european-research-council-award-336360","Anionic PhosPhoLipids in plant receptor kinase signaling","€1,797,840","In plants, receptor kinases form the largest family of plasma membrane (PM) receptors and they are involved in virtually all aspects of the plant life, including development, immunity and reproduction. In animals, key molecules that orchestrate the recruitment of signaling proteins to membranes are anionic phospholipids (e.g. phosphatidylinositol phosphate or PIPs). Besides, recent reports in animal and yeast cells suggest the existence of PM nanodomains that are independent of cholesterol and l",{"id":952,"funder":7,"programme":8,"title":953,"piName":14,"institution":954,"country":53,"year":13,"amount":14,"abstract":955},"cordis-european-research-council-award-336983","The Elementary Theory of Partially Commutative Groups","UNIVERSIDAD DEL PAIS VASCO\u002F EUSKAL HERRIKO UNIBERTSITATEA","The solution of Tarski's problems on the first-order theory of freegroups has uncovered deep connections between Model Theory, Geometryand Group Theory and served as a nexus and  motivation for manyclassical results in Geometric Group Theory and Theoretical ComputerScience.Just as the Tarski problems connected the theory of free groups withthe geometry of trees, our goal is to point at a new direction inGroup Theory and develop appropriate generalisations of the techniquesand results whose natur",{"id":957,"funder":7,"programme":8,"title":958,"piName":14,"institution":938,"country":85,"year":13,"amount":702,"abstract":959},"cordis-european-research-council-award-336427","Maintenance of epigenome integrity in response to DNA damage","Protection of genome integrity is crucial for maintaining cell identity and viability. However, the organisation of DNA with histone proteins into chromatin in eukaryotic cell nuclei poses structural constraints to the detection and repair of DNA lesions. Dynamic and tightly controlled changes in chromatin organisation are thus critical for an efficient response to DNA damage, while at the same time preserving chromatin integrity. Yet, the underlying regulatory mechanisms are still poorly charac",{"id":961,"funder":7,"programme":8,"title":962,"piName":14,"institution":938,"country":85,"year":13,"amount":702,"abstract":963},"cordis-european-research-council-award-337365","Multi-level Selection in a Heterogeneous Environment","Our understanding of natural and sexual selection is too limited to allow predicting evolutionary responses in the wild. This knowledge gap is due in part to lack of temporal and spatial replication, of non-morphological studies, and of statistical power.This project offers to integrate measures of selection at multiple levels (selection acting on phenotypic, additive genetic and genomic variations) for multiple potentially correlated traits (morphology, life-history, sexual ornament and persona",{"id":965,"funder":7,"programme":8,"title":966,"piName":14,"institution":938,"country":85,"year":13,"amount":967,"abstract":968},"cordis-european-research-council-award-337579","Evolution of a new stable phenotype: a genetic, developmental and behavioural analysis","€1,386,660","How robust phenotypes evolve despite developmental noise remains unclear. Individuals from natural populations usually display more stable phenotypes than laboratory mutants and hybrids. This suggests that there are genetic mechanisms that stabilize phenotypes and that these differ between isolated populations. We want to address here an unexplored yet fundamental question in biology: how does a stable phenotype appear during evolution? We will focus on the evolution of a new genital sensory org",{"id":970,"funder":7,"programme":8,"title":971,"piName":14,"institution":972,"country":852,"year":13,"amount":973,"abstract":974},"cordis-european-research-council-award-337905","Non-invasive genomic analysis of cancer using circulating tumour DNA","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€1,769,380","Non-invasive genomic analysis of cancer can revolutionize the study of tumour evolution, heterogeneity, and drug resistance. Clinically applied, this can transform current practice in cancer diagnosis and management. Cell-free DNA in plasma contains tumour-specific sequences. This circulating tumour DNA (ctDNA) is a promising source of genomic and diagnostic information, readily accessible non-invasively. The study of ctDNA is therefore timely and of great importance. But it is also very challen",{"id":976,"funder":7,"programme":8,"title":977,"piName":14,"institution":972,"country":852,"year":13,"amount":978,"abstract":979},"cordis-european-research-council-award-338060","Dynamics, noise, and coupling in gene circuit modules","€1,499,571","Cells must integrate output from multiple genetic circuits in order to correctly control cellular processes. Despite much work characterizing regulation in these circuits, how circuits interact to control global cellular programs remains unclear. This is particularly true given that recent research at the single cell level has revealed that genetic circuits often generate variable or stochastic regulation dynamics. In this proposal we will use a multi-disciplinary approach, combining modelling a",{"id":981,"funder":7,"programme":8,"title":982,"piName":14,"institution":972,"country":852,"year":13,"amount":983,"abstract":984},"cordis-european-research-council-award-337054","Production Networks in Macroeconomics","€940,200","A modern economy is an intricately linked web of specialized production units, each relying on the flow of inputs from their suppliers to produce their own output which, in turn, is routed towards other downstream units. Recent work in economics stresses that the structure of this production network is key in determining whether and how microeconomic shocks can propagate throughout the economy and shape aggregate outcomes.This project has two main goals. First, it aims to provide novel evidence ",{"id":986,"funder":7,"programme":8,"title":987,"piName":14,"institution":972,"country":852,"year":13,"amount":988,"abstract":989},"cordis-european-research-council-award-336159","Synergistic Modelling of Molecular Effects via Chemical and Biological Data Integration","€1,499,558","While conventionally effects of a chemical structure on a biological system have been determined for individual compounds, one at a time, it is now becoming apparent that biological effects of compound combination are not additive, but often conditional (antagonistic or synergistic) in nature. This phenomenon is of relevance both in the medicinal context (where drugs can be combined to have a synergistic effect), as well as the area of toxicology (where the simultaneous application of compounds ",{"id":991,"funder":7,"programme":8,"title":992,"piName":14,"institution":993,"country":182,"year":13,"amount":994,"abstract":995},"cordis-european-research-council-award-335587","Modulation of neocortical microcircuits for attention","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€1,466,505","At every moment in time, the brain receives a vast amount of sensory information about the environment. This makes attention, the process by which we select currently relevant stimuli for processing and ignore irrelevant input, a fundamentally important brain function. Studies in primates have yielded a detailed description of how attention to a stimulus modifies the responses of neuronal ensembles in visual cortex, but how this modulation is produced mechanistically in the circuit is not well u",{"id":997,"funder":7,"programme":8,"title":998,"piName":14,"institution":999,"country":182,"year":13,"amount":1000,"abstract":1001},"cordis-european-research-council-award-335205","Enantioselective Reactions on Model Chirally Modified Surfaces","CHRISTIAN-ALBRECHTS-UNIVERSITAET  ZU KIEL","€1,589,736","Imparting chirality to non-chiral metal surfaces by adsorption of chiral modifiers is a highly promising route to create effective heterogeneously catalyzed processes for production of enantiopure pharmaceuticals. A molecular-level understanding of enantioselective processes on chiral surfaces is an importance prerequisite for the rational design of new enantiospecific catalysts. With the research outlined in this proposal we are aiming at a fundamental level understanding of the structure of ch",{"id":1003,"funder":7,"programme":8,"title":1004,"piName":14,"institution":1005,"country":182,"year":13,"amount":1006,"abstract":1007},"cordis-european-research-council-award-337490","3D structures of bacterial supramolecular assemblies by solid-state NMR","FORSCHUNGSVERBUND BERLIN EV","€1,456,000","Supramolecular assemblies – formed by the self-assembly of hundreds of protein subunits – are part of bacterial nanomachines involved in key cellular processes. Important examples in pathogenic bacteria are pili and type 3 secretion systems (T3SS) that mediate adhesion to host cells and injection of virulence proteins. Structure determination at atomic resolution of such assemblies by standard techniques such as X-ray crystallography or solution NMR is severely limited: Intact T3SSs or pili cann",{"id":1009,"funder":7,"programme":8,"title":1010,"piName":14,"institution":993,"country":182,"year":13,"amount":1011,"abstract":1012},"cordis-european-research-council-award-337415","Mechanisms of chromosome segregation in mammalian oocytes","€1,487,611","All animal life starts with the fertilization of an egg. A haploid egg and a haploid sperm fuse and together they form a new genetically unique embryo. But surprisingly, eggs frequently contain an incorrect number of chromosomes. Depending on the age of the woman, 10-50% of eggs are chromosomally abnormal. This high percentage of abnormal eggs results from chromosome segregation errors during oocyte maturation, the process by which a diploid oocyte matures into a haploid egg. Thus, errors during",{"id":1014,"funder":7,"programme":8,"title":1015,"piName":14,"institution":1016,"country":182,"year":13,"amount":1017,"abstract":1018},"cordis-european-research-council-award-337258","An integrated assessment of recent evolutionary change  through genome wide mapping of regulatory changes and signatures of selection in natural sculpin (Cottus) hybrids","CARL VON OSSIETZKY UNIVERSITAET OLDENBURG","€1,377,162","It is the unprecedented access to genome wide data that highlights the potential of current evolutionary studies and this proposal aims at exploiting this progress to analyze evolutionary processes in a well-established fish system of hybrid speciation. We study natural populations of freshwater fish referred to as sculpins (Cottus). In these we have identified species that have recently (\u003C200 years) hybridized as a result of secondary contact through man-made canals between river systems. This ",{"id":1020,"funder":7,"programme":8,"title":1021,"piName":14,"institution":857,"country":858,"year":13,"amount":702,"abstract":1022},"cordis-european-research-council-award-335328","Deconstructing action planning and action observation in parietal circuits in rats","The posterior parietal cortex (PPC) mediates cognitive motor functions including motor planning and action understanding. The latter process is thought to occur via ‘mirror’ neurons, which fire both when an animal performs an action and when it observes a cohort performing the same action. The extraordinary tuning properties of PPC cells require the convergence of sensory and motor inputs from several areas, but the function of these inputs is ill-defined since it is not yet feasible in humans o",{"id":1024,"funder":7,"programme":8,"title":1025,"piName":14,"institution":1026,"country":581,"year":13,"amount":1027,"abstract":1028},"cordis-european-research-council-award-335929","Plasma-assisted development and functionalization of electrospun mats for tissue engineering purposes","UNIVERSITEIT GENT","€1,391,100","In this project, I will explore the unique combination of two fascinating research themes: electrospinning and plasma technology. Electrospun nanofibrous matrices (so-called mats) are an exciting class of materials with a wide range of possible applications. Nevertheless, the development and functionalization of these electrospun materials remain very challenging tasks.Atmospheric pressure plasma technology will be utilized by my research group to create advanced biodegradable electrospun mats w",{"id":1030,"funder":7,"programme":8,"title":1031,"piName":14,"institution":1026,"country":581,"year":13,"amount":1032,"abstract":1033},"cordis-european-research-council-award-337344","Novel Saints. Ancient novelistic heroism in the hagiography of Late Antiquity and the early Middle Ages","€1,467,300","The novel is today the most popular literary genre worldwide. Its early history has not been written yet. In order to enhance our understanding of this history (both conceptually and cross-culturally), this project offers the first comprehensive reconstruction and interpretation of the persistence of ancient novelistic material in hagiographical narrative traditions in the Mediterranean in Late Antiquity and the early Middle Ages (4th-12th cent.). This period constitutes a blind spot on the rada",{"id":1035,"funder":7,"programme":8,"title":1036,"piName":14,"institution":1037,"country":182,"year":13,"amount":1038,"abstract":1039},"cordis-european-research-council-award-336978","Light Field Imaging and Analysis","UNIVERSITAT KONSTANZ","€1,466,100","One of the most fundamental challenges in computer vision is to reliably establish correspondence - how to match a location in one image to its counterpart in another. It lies at the heart of numerous important problems, for example stereo, optical flow, tracking and the reconstruction of scene geometry from several photographs. The most popular approaches to solve these problems are based on the simplification that a scene point looks the same from wherever and whenever it is observed. However,",{"id":1041,"funder":7,"programme":8,"title":1042,"piName":14,"institution":1043,"country":66,"year":13,"amount":1044,"abstract":1045},"cordis-european-research-council-award-337116","Mechanisms of transcription in HIV latency; novel strategies to activate","ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM","€1,499,942","The persistence of a transcriptionally competent but latent HIV infected memory CD4+T cell reservoir, despite the effectiveness of Highly Active Antiretroviral therapy (HAART) against active virus, presents the main impediment to HIV eradication. A novel concept in HIV eradication is to activate latent virus to subsequently eliminate with HAART. Much effort has gone into identification of protein complexes that regulate HIV LTR activity. Strategies have mainly relied on candidate approaches. How",{"id":1047,"funder":7,"programme":8,"title":1048,"piName":14,"institution":1049,"country":852,"year":13,"amount":1050,"abstract":1051},"cordis-european-research-council-award-338065","Cognitive and Biological Factors of Mathematical Learning and Achievement","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€1,999,859","Mathematical competence is essential for an individual’s functioning in society and for societal prosperity and progress in general. Crucially, the specific cognitive and biological factors that determine high, average, or low mathematical achievement are still poorly understood. The current project aims to address this gap by examining the link between mathematical achievement (cognitive factors) and brain indices (biological factors) across the developmental trajectory and for different compet",{"id":1053,"funder":7,"programme":8,"title":1054,"piName":14,"institution":1049,"country":852,"year":13,"amount":1055,"abstract":1056},"cordis-european-research-council-award-335716","Internet Geographies: Changing Connectivities and the Potentials of Sub-Saharan Africa's Knowledge Economy","€1,499,110","Until recently, access to telecommunication technologies was out of reach for all but the most privileged citizens in Sub-Saharan Africa (SSA). However, recent radical changes that have connected hundreds of millions have encouraged politicians, journalists, academics, and citizens to speak of an IT-fuelled economic revolution happening on the continent. Many see potentials to move away from primary industries and towards a focus on quaternary and quinary sectors (the knowledge-based parts of th",{"id":1058,"funder":7,"programme":8,"title":1059,"piName":14,"institution":1049,"country":852,"year":13,"amount":1060,"abstract":1061},"cordis-european-research-council-award-337108","Changing Structures of Islamic Authority and Consequences for Social Change: A Transnational Review","€1,376,704","Research on Muslims in Europe or in the Muslim majority countries has since September 11, mainly focused on understanding the causes of religious radicalization. Largely ignored in the public debates, as well as in academic scholarship, is recognition of the rapid growth in a number of prominent initiatives emerging within Muslims in the west that are aimed at initiating intellectual revival within Islam. Drawing inspiration from the thinkers such as Al-Ghazali or Ibn-Rushd (associated with the ",{"id":1063,"funder":7,"programme":8,"title":1064,"piName":14,"institution":1049,"country":852,"year":13,"amount":1065,"abstract":1066},"cordis-european-research-council-award-335421","Robust Financial Mathematics: model-ambiguous framework for valuation and risk management","€1,218,639","The last forty years have seen a remarkable interplay between Mathematics and contemporary Finance. At the heart of the successful growth of Mathematical Finance was a perfect fit between its dominant model--specific framework and the tools of stochastic analysis. However, this approach has always had important limitations, and the dangers of overreach have been illustrated by the dramatic events of the recent financial crisis.I set out to create a coherent mathematical framework for valuation, ",{"id":1068,"funder":7,"programme":8,"title":1069,"piName":14,"institution":1049,"country":852,"year":13,"amount":1070,"abstract":1071},"cordis-european-research-council-award-337757","Optical imaging of nanoscopic dynamics and potentials","€1,498,352","I propose to develop and apply a novel approach to optical microscopy to enable the direct visualization and study of dynamics on the nanoscale in biological and condensed matter physics. Given the speed with which nanoscopic objects move at ambient condition, this requires simultaneously very fast (ms) and precise (nm) imaging. The challenge is to  avoid excessive perturbation of the system and enable imaging in biologically compatible environments without compromising imaging performance by pu",{"id":1073,"funder":7,"programme":8,"title":1074,"piName":14,"institution":1049,"country":852,"year":13,"amount":1075,"abstract":1076},"cordis-european-research-council-award-337574","Unifying Domestication and Evolution through Ancient DNA","€1,492,844","Between 15,000 and 10,000 years ago, human populations in numerous regions of the world forged closer relationships with plants and animals. This domestication process not only significantly altered the genetic, behavioural and phenotypic characteristics of all the species involved, it also laid the foundations for the first urban societies.This project will take advantage of revolutionary genetic technologies to characterise, for the first time, the nuclear genomes of ancient dogs, pigs, and ch",{"id":1078,"funder":7,"programme":8,"title":1079,"piName":14,"institution":1049,"country":852,"year":13,"amount":1080,"abstract":1081},"cordis-european-research-council-award-338258","Optical Quantum Control of Magnetic Molecules","€1,498,300","A revolution is underway, as molecular magnets are establishing a fundamental link between spintronics, molecular electronics and quantum computation. On the other hand, we know almost nothing on how a magnetic molecule is affected by electrons flowing through it or by the excitation of a molecular group. OptoQMol will investigate these uncharted waters by developing innovative, ultra-clean methods that will provide information inaccessible to established procedures. This will allow an unprecede",{"id":1083,"funder":7,"programme":8,"title":1084,"piName":14,"institution":1085,"country":182,"year":13,"amount":1086,"abstract":1087},"cordis-european-research-council-award-335367","Biologically individualized, model-based radiotherapy on the basis of multi-parametric molecular tumour profiling","EBERHARD KARLS UNIVERSITAET TUEBINGEN","€1,370,799","High precision radiotherapy (RT) allows extremely flexible tumour treatments achieving highly conformal radiation doses while sparing surrounding organs at risk. Nevertheless, failure rates of up to 50% are reported for head and neck cancer (HNC) due to radiation resistance induced by pathophysiologic factors such as hypoxia and other clinical factors as HPV-status, stage and tumour volume.This project aims at developing a multi-parametric model for individualized RT (iRT) dose prescriptions in ",{"id":1089,"funder":7,"programme":8,"title":1090,"piName":14,"institution":1091,"country":852,"year":13,"amount":1092,"abstract":1093},"cordis-european-research-council-award-336306","The role of mechanical forces induced by prenatal movements in joint morphogenesis","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€1,499,501","Most joints start off the same during embryonic development, as two opposing cartilage surfaces, and are moulded into the diverse range of shapes seen in the adult in a process known as morphogenesis. While we understand very little of the biological or mechanobiological processes driving joint morphogenesis, there is evidence to suggest that fetal movements play a critical role in joint shape development. Developmental Dysplasia of the Hip (DDH), where the hip is partly or fully dislocated, is ",{"id":1095,"funder":7,"programme":8,"title":1096,"piName":14,"institution":1091,"country":852,"year":13,"amount":1097,"abstract":1098},"cordis-european-research-council-award-335724","Synthetic species of the mosquito vectors of human disease: from hybrid genetics to a new type of vector control","€1,497,606","In this project I aim to generate the first synthetic species of mosquitoes derived from Anopheles gambiae, the main vector of malaria, and also from Aedes albopictus, a vector of several viral diseases, that has recently invaded Europe. The experimental generation of artificial species will prove invaluable to shed light on major biological questions concerning reproductive isolation. Furthermore, I propose a novel strategy to reduce the incidence of disease transmitted by these vectors based o",{"id":1100,"funder":7,"programme":8,"title":1101,"piName":14,"institution":911,"country":182,"year":13,"amount":1102,"abstract":1103},"cordis-european-research-council-award-336749","Interfacing quantum states in carbon nanotube devices","€1,739,680","Coherent control and sensitive detection of quantum states in condensed matter are among the most topical challenges of modern physics. They drive the development of novel materials, theoretical concepts, and experimental methods to advance our understanding of fundamental laws of quantum mechanics and to create transformative technologies for future applications. During the past decades carbon has emerged as a new material platform to address these challenges: graphene and carbon nanotubes have",{"id":1105,"funder":7,"programme":8,"title":1106,"piName":14,"institution":1107,"country":66,"year":13,"amount":1108,"abstract":1109},"cordis-european-research-council-award-337062","DRAGNET: A high-speed, wide-angle camera for catching extreme astrophysical events","STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN","€1,964,587","Looking up on a starry night, it’s easy to imagine that the Universe is unchanging. In reality, however, the Universe is teeming with activity: there are massive explosions from accreting black holes, bright radio flashes from ultra-magnetic pulsars, and likely other spectacles that have so far escaped our prying eyes. These fleeting events can happen faster than the blink of an eye and, importantly, they trace the most extreme astrophysical phenomena. Catching these rare performances poses a ma",{"id":1111,"funder":7,"programme":8,"title":1112,"piName":14,"institution":1113,"country":110,"year":13,"amount":14,"abstract":1114},"cordis-european-research-council-award-336607","Role of miRNAs in brown and white adipose tissue differentiation and function","UNIVERSITE DE GENEVE","Mammals have two types of fat: brown and white, with opposing functions. The white adipose tissue (WAT) is an important regulator of the whole body homeostasis that also serves to store energy in form of triglycerides (TGs). The main function of the brown adipose tissue (BAT) is to catabolize lipids in order to produce heat, a function that can be induced by cold exposure or diet. Disruption of the normal differentiation or development of the WAT causes ectopic lipid storage and severe pathology",{"id":1116,"funder":7,"programme":8,"title":1117,"piName":14,"institution":1118,"country":852,"year":13,"amount":1119,"abstract":1120},"cordis-european-research-council-award-337128","The Archaeology of Agricultural Resilience in Eastern Africa","UNIVERSITY OF YORK","€1,196,701","The twin concepts of sustainability and conservation that are so pivotal within current debates regarding economic development and biodiversity protection both contain an inherent temporal dimension, since both refer to the need to balance short-term gains with long-term resource maintenance. Proponents of resilience theory and of development based on ‘indigenous knowledge’ have thus argued for the necessity of including archaeological, historical and palaeoenvironmental components within develo",{"id":1122,"funder":7,"programme":8,"title":1123,"piName":14,"institution":806,"country":110,"year":13,"amount":1124,"abstract":1125},"cordis-european-research-council-award-336506","Crystal Engineering for Molecular Organic Semiconductors","€1,477,472","The urgent need to develop inexpensive and ubiquitous solar energy conversion cannot be overstated. Solution processed organic semiconductors can enable this goal as they support drastically less expensive fabrication techniques compared to traditional semiconductors. Molecular organic semiconductors (MOSs) offer many advantages to their more-common pi-conjugated polymer counterparts, however a clear and fundamental challenge to enable the goal of high performance solution-processable molecular ",200,{"programme":8,"total":1128,"withPiName":1129,"firstYear":1130,"lastYear":1131,"countryCount":1132,"perYear":1133,"topInstitutions":1191,"topCountries":1256},7919,572,2008,2027,52,[1134,1136,1139,1142,1145,1148,1151,1153,1156,1159,1162,1165,1168,1171,1174,1177,1180,1183,1186,1189],{"year":1130,"count":1135},279,{"year":1137,"count":1138},2009,157,{"year":1140,"count":1141},2010,302,{"year":1143,"count":1144},2011,447,{"year":1146,"count":1147},2012,524,{"year":1149,"count":1150},2013,456,{"year":13,"count":1152},297,{"year":1154,"count":1155},2015,366,{"year":1157,"count":1158},2016,376,{"year":1160,"count":1161},2017,419,{"year":1163,"count":1164},2018,582,{"year":1166,"count":1167},2019,393,{"year":1169,"count":1170},2020,384,{"year":1172,"count":1173},2021,394,{"year":1175,"count":1176},2022,514,{"year":1178,"count":1179},2023,512,{"year":1181,"count":1182},2024,473,{"year":1184,"count":1185},2025,482,{"year":1187,"count":1188},2026,556,{"year":1131,"count":1190},6,[1192,1194,1197,1199,1200,1203,1205,1207,1210,1213,1216,1218,1221,1223,1226,1229,1232,1235,1237,1239,1242,1244,1247,1250,1253],{"name":1193,"count":1173},"Centre National de la Recherche Scientifique CNRS",{"name":1195,"count":1196},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",175,{"name":20,"count":1198},129,{"name":302,"count":1198},{"name":1201,"count":1202},"Hebrew University of Jerusalem",112,{"name":59,"count":1204},110,{"name":454,"count":1206},107,{"name":1208,"count":1209},"Weizmann Institute of Science",104,{"name":1211,"count":1212},"Eidgenoessische Technische Hochschule Zuerich",87,{"name":1214,"count":1215},"Kobenhavns Universitet",85,{"name":1217,"count":1215},"Universiteit Gent",{"name":1219,"count":1220},"Universiteit van Amsterdam",84,{"name":246,"count":1222},83,{"name":1224,"count":1225},"Ludwig-Maximilians-Universitaet Muenchen",82,{"name":1227,"count":1228},"Institut National de la Sante Et de la Recherche Medicale",78,{"name":1230,"count":1231},"Universiteit Utrecht",76,{"name":1233,"count":1234},"Imperial College of Science Technology and Medicine",71,{"name":1236,"count":1234},"Katholieke Universiteit Leuven",{"name":1238,"count":1234},"Technische Universiteit Delft",{"name":1240,"count":1241},"Technion - Israel Institute of Technology",70,{"name":1243,"count":1241},"Technische Universitaet Muenchen",{"name":1245,"count":1246},"Universiteit Leiden",69,{"name":1248,"count":1249},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",67,{"name":1251,"count":1252},"The University of Edinburgh",64,{"name":1254,"count":1255},"Helsingin Yliopisto",57,[1257,1259,1261,1263,1265,1266,1268,1270,1272,1274,1276,1278,1280,1282,1283,1285,1287,1289,1291,1293,1296,1298,1301,1304,1307],{"name":182,"count":1258},1346,{"name":852,"count":1260},1007,{"name":85,"count":1262},932,{"name":66,"count":1264},772,{"name":12,"count":1179},{"name":53,"count":1267},475,{"name":455,"count":1269},470,{"name":110,"count":1271},389,{"name":581,"count":1273},348,{"name":148,"count":1275},291,{"name":651,"count":1277},269,{"name":34,"count":1279},189,{"name":201,"count":1281},137,{"name":443,"count":1204},{"name":858,"count":1284},108,{"name":141,"count":1286},92,{"name":21,"count":1288},68,{"name":46,"count":1290},60,{"name":123,"count":1292},43,{"name":1294,"count":1295},"EL",41,{"name":28,"count":1297},36,{"name":1299,"count":1300},"HU",32,{"name":1302,"count":1303},"TR",24,{"name":1305,"count":1306},"SI",14,{"name":1308,"count":1309},"EE",10]