[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-starting-grant-2015":3,"awarded-stats-erc-starting-grant":1071},{"awarded":4,"total":1070},[5,16,23,30,37,42,47,53,58,64,70,76,82,87,92,97,102,107,112,117,121,126,132,136,140,146,152,158,163,169,174,180,186,192,196,200,205,210,216,221,226,231,236,241,246,251,256,261,268,273,277,282,289,296,302,308,314,319,325,330,336,342,347,353,360,366,372,378,384,390,395,401,407,412,417,422,427,433,438,443,447,452,457,463,467,471,476,482,487,492,496,501,505,510,514,518,524,531,536,541,546,551,558,562,567,573,578,583,588,592,597,602,608,612,617,623,627,632,638,645,651,657,662,667,673,677,683,688,694,699,705,709,715,721,727,733,738,744,749,753,758,763,769,774,780,786,791,796,800,805,811,816,822,827,832,836,841,846,851,856,862,866,872,878,883,888,893,898,903,908,914,919,924,931,937,943,948,953,959,964,970,975,979,983,989,995,1000,1004,1009,1015,1020,1025,1031,1037,1042,1047,1052,1056,1061,1065],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-335590","European Research Council","ERC Starting Grant","Neurovascular Interactions and Pathfinding in the Spinal Motor System",null,"OSPEDALE SAN RAFFAELE SRL","IT",2015,"€1,653,000","Neurons and blood vessels rely on common guidance signals to wire into elaborate neural and vascular networks that are closely juxtaposed and interdependent: vascular supply of oxygen and nutrients is essential to sustain the high metabolic rate of the nervous system, and conversely neural control of vascular tone is crucial for circulatory homeostasis. However, it remains unclear how the nervous and vascular systems establish an intimate physical and functional relationship. This proposal seeks",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":20,"year":13,"amount":21,"abstract":22},"cordis-european-research-council-award-336167","Cardiovascular Health effects of Air pollution in Andhra Pradesh, India","FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA","ES","€1,200,000","While there is convincing evidence that exposure to particulate air pollution causes cardiovascular mortality and morbidity, nearly all of this evidence is based on populations in high-income countries where concentrations are relatively low. There is large uncertainty regarding the relationship between combustion particles and cardiovascular risk for concentrations higher than outdoor concentrations in urban areas of high-income countries and lower than active smoking.  Exposures for our study ",{"id":24,"funder":7,"programme":8,"title":25,"piName":10,"institution":26,"country":27,"year":13,"amount":28,"abstract":29},"cordis-european-research-council-award-335880","Spectral Fingerprints of Neuronal Interactions","EBERHARD KARLS UNIVERSITAET TUEBINGEN","DE","€1,494,480","How does cognition result from complex neuronal interactions within and between brain regions? Substantial progress has been made understanding the functional properties of individual neurons, but we lack understanding of how they work together. Neuronal oscillations are ubiquitous in the brain. The frequencies of these oscillations reflect the biophysical properties of underlying circuit interactions. Thus, frequency-specific oscillations may serve as ‘spectral fingerprints’ of specific circuit",{"id":31,"funder":7,"programme":8,"title":32,"piName":10,"institution":33,"country":34,"year":13,"amount":35,"abstract":36},"cordis-european-research-council-award-639945","Algorithms for Complex Collective Decisions on Structured Domains","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","UK","€1,395,933","Algorithms for Complex Collective Decisions on Structured Domains. The aim of this proposal is to substantially advance the field of Computational Social Choice, by developing new tools and methodologies that can be used for making complex group decisions in rich and structured environments. We consider settings where each member of a decision-making body has preferences over a finite set of alternatives, and the goal is to synthesise a collective preference over these alternatives, which may ta",{"id":38,"funder":7,"programme":8,"title":39,"piName":10,"institution":33,"country":34,"year":13,"amount":40,"abstract":41},"cordis-european-research-council-award-639652","Online Labour: The Construction of Labour Markets, Institutions and Movements on the Internet","€1,499,911","World Bank, EC Joint Research Centre, and other bodies have recently highlighted the potential of online labour markets to boost employment and economic growth. While national job markets have stagnated, online labour markets that connect firms with knowledge and service workers around the world have grown up to 60% a year.An overlooked aspect of these markets is that they extricate workers and employers from national institutional frameworks, such as employment law and collective bargaining, an",{"id":43,"funder":7,"programme":8,"title":44,"piName":10,"institution":33,"country":34,"year":13,"amount":45,"abstract":46},"cordis-european-research-council-award-638578","Stories of Survival: Recovering the Connected Histories of Eastern Christianity in the Early Modern World","€1,499,985","From Lebanese immigrants in Argentina to Iraqi refugees in Sweden, Eastern Christians can be found today scattered across the entire world.  Too often, however, this global migration has been seen purely as a modern development, one arising from contemporary political and confessional events in the Middle East, while in fact this phenomenon had its roots in the early modern period.  From the sixteenth century onwards, Christians from the Ottoman Empire set out for distant worlds and foreign land",{"id":48,"funder":7,"programme":8,"title":49,"piName":10,"institution":50,"country":20,"year":13,"amount":51,"abstract":52},"cordis-european-research-council-award-637116","Photonic Electrodes for Enhanced Light Management in Optoelectronic Devices","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","€1,500,000","Nanostructured dielectric and metallic photonic architectures can concentrate the electric field through resonances, increase the light optical path by strong diffraction and exhibit many other interesting optical phenomena that cannot be achieved with traditional lenses and mirrors. The use of these structures within actual devices will be most beneficial for enhanced light absorption in thin solar cells, photodetectors and to develop new sensors and light emitters. However, emerging optoelectr",{"id":54,"funder":7,"programme":8,"title":55,"piName":10,"institution":50,"country":20,"year":13,"amount":56,"abstract":57},"cordis-european-research-council-award-639226","The Power of Maternal Microbes on Infant Health","€1,499,979","Recent reports suggest that early microbial colonization has an important role for in promoting health. This may contribute to reduce the risk of chronic diseases such as obesity, allergies and inflammatory conditions. Advances in understanding host-microbe interactions imply that maternal microbiota plays a crucial role on health programming. This process begins in utero and it is modulated by mode of delivery and diet. My research has shown that i) specific shifts in milk microbial composition",{"id":59,"funder":7,"programme":8,"title":60,"piName":10,"institution":61,"country":62,"year":13,"amount":10,"abstract":63},"cordis-european-research-council-award-639707","Adaptive immunity in prokaryotes: how Bacteria do not forgive and do not forget their enemies","TECHNISCHE UNIVERSITEIT DELFT","NL","Microbes in natural ecosystems are under constant evolutionary pressure from viruses. To survive in this hostile environment microbes have evolved an adaptive immune system called CRISPR-Cas. The immune system is based on incorporation of invader DNA sequences in a memory locus (CRISPR), the formation of guide RNAs from this locus, and the degradation of invading target DNA using CRISPR RNA-guided protein complexes. Invaders escape immunity by making point mutations in the targeted region of the",{"id":65,"funder":7,"programme":8,"title":66,"piName":10,"institution":67,"country":27,"year":13,"amount":68,"abstract":69},"cordis-european-research-council-award-638573","Mechanisms of Gene Silencing by the Glucocorticoid Receptor","HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH","€1,496,275","I propose to decipher the unresolved molecular paradox of positive versus negative gene regulation by the Glucocorticoid Receptor (GR). GR is one of the most potent anti-inflammatory drug targets in clinical use today, and one of the most powerful metabolic regulators. Unfortunately, its unique ability to efficiently shut off inflammatory gene expression is accompanied by serious side effects. These undesired effects are attributed to the transcriptional activation of its metabolic target genes ",{"id":71,"funder":7,"programme":8,"title":72,"piName":10,"institution":73,"country":20,"year":13,"amount":74,"abstract":75},"cordis-european-research-council-award-638284","Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface","UNIVERSIDAD DE ZARAGOZA","€1,498,636","Europe is facing a striking change in its demographics with an increasingly larger proportion of citizens aged 65 years and over. Aging is characterized by a progressive decline in the physiological functions of the body, with very notable effects on the heart. These effects are associated with a higher prevalence of arrhythmias, which, on top of deteriorating quality of life, increase the risk of other cardiovascular diseases like stroke, heart failure and neurological sequelae. Investigations ",{"id":77,"funder":7,"programme":8,"title":78,"piName":10,"institution":79,"country":80,"year":13,"amount":10,"abstract":81},"cordis-european-research-council-award-639366","Foundations of Efficient Lattice Cryptography","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","FR","Public key cryptography is the backbone of internet security. Yet it is very likely that within the next few decades some government or corporate entity will succeed in building a general-purpose quantum computer that is capable of breaking all of today's public key protocols. Lattice cryptography, which appears to be resilient to quantum attacks, is currently viewed as the most promising candidate to take over as the basis for cryptography in the future.  Recent theoretical breakthroughs have a",{"id":83,"funder":7,"programme":8,"title":84,"piName":10,"institution":79,"country":80,"year":13,"amount":85,"abstract":86},"cordis-european-research-council-award-639139","From Geometry to Motion: inverse modeling of complex mechanical structures","€1,498,570","With the considerable advance of automatic image-based capture in Computer Vision and Computer Graphics these latest years, it becomes now affordable to acquire quickly and precisely the full 3D geometry of many mechanical objects featuring intricate shapes. Yet, while more and more geometrical data get collected and shared among the communities, there is currently very little study about how to infer the underlying mechanical properties of the captured objects merely from their geometrical conf",{"id":88,"funder":7,"programme":8,"title":89,"piName":10,"institution":90,"country":80,"year":13,"amount":10,"abstract":91},"cordis-european-research-council-award-639554","Secure Computation on Encrypted Data","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","Recent trends in computing have prompted users and organizations to store an increasingly large amount of sensitive data at third party locations in the cloud outside of their direct control. Storing data remotely poses an acute security threat as these data are outside our control and could potentially be accessed by untrusted parties. Indeed, the reality of these threats have been borne out by the Snowden leaks and hundreds of data breaches each year. In order to protect our data, we will need",{"id":93,"funder":7,"programme":8,"title":94,"piName":10,"institution":79,"country":80,"year":13,"amount":95,"abstract":96},"cordis-european-research-council-award-637972","Robots with animal-like resilience","€1,499,501","Despite over 50 years of research in robotics, most existing robots are far from being as resilient as the simplest animals: they are fragile machines that easily stop functioning in difficult conditions. The goal of this proposal is to radically change this situation by providing the algorithmic foundations for low-cost robots that can autonomously recover from unforeseen damages in a few minutes. The current approach to fault tolerance is inherited from safety-critical systems (e.g. spaceships",{"id":98,"funder":7,"programme":8,"title":99,"piName":10,"institution":79,"country":80,"year":13,"amount":100,"abstract":101},"cordis-european-research-council-award-637339","Coq for Homotopy Type Theory","€1,498,290","Every year, software bugs cost hundreds of millions of euros to companies and administrations. Hence, software quality is a prevalent notion and interactive theorem provers based on type theory have shown their efficiency to prove correctness of important pieces of software like the C compiler of the CompCert project.  One main interest of such theorem provers is the ability to extract directly the code from the proof. Unfortunately, their democratization suffers from a major drawback, the misma",{"id":103,"funder":7,"programme":8,"title":104,"piName":10,"institution":90,"country":80,"year":13,"amount":105,"abstract":106},"cordis-european-research-council-award-637420","Unravelling cluster root development in white lupin","€1,997,103","Plant development is continuous throughout their lifetime and reflects their ability to adapt to their environment. This developmental plasticity is very obvious in the development of the root system. Surprisingly, the fundamental mechanisms of root development have been studied into great detail but the effect of the environment on its plasticity is still largely unknown. I will use phosphate, since this nutrient has a very low mobility in soil, as a mean to study plant developmental adaptation",{"id":108,"funder":7,"programme":8,"title":109,"piName":10,"institution":90,"country":80,"year":13,"amount":110,"abstract":111},"cordis-european-research-council-award-638898","Fanconi anemia : a disease model to understand causes and consequences of common fragile site instability.","€1,462,383","Originally described by cytogeneticists, common fragile sites (CFSs) are chromosomal regions known for their susceptibility to break and rearrange aberrantly, thus altering the expression of genes located therein. CFS instability is associated with tumor development and pathogenic copy number variations. Recent advances have significantly contributed to dissect the molecular bases of CFS instability, yet a unifying model for their unique breakage propensity has not been determined. Fanconi anemi",{"id":113,"funder":7,"programme":8,"title":114,"piName":10,"institution":115,"country":80,"year":13,"amount":10,"abstract":116},"cordis-european-research-council-award-636744","Josephson Junction Spectroscopy of Mesoscopic Systems","COLLEGE DE FRANCE","Spectroscopy is a powerful tool to probe matter.  By measuring the spectrum of elementary excitations, one reveals the symmetries and interactions inherent in a physical system.  Mesoscopic devices, which preserve quantum coherence over lengths larger than the atomic scale, offer a unique possibility to both engineer and investigate excitations at the single quanta level.  Unfortunately, conventional spectroscopy techniques are inadequate for coupling radiation to mesoscopic systems and detectin",{"id":118,"funder":7,"programme":8,"title":119,"piName":10,"institution":90,"country":80,"year":13,"amount":10,"abstract":120},"cordis-european-research-council-award-636903","Active Magnetorheological Elastomers: from Hierarchical Composite Materials to tailored Instabilities","In recent years, there has been an increased effort by scientists to obtain new composite materials with extreme properties. Inspired by natural and biological processes, scientists have proposed the use of hierarchical architectures (i.e., assembly of structural components) spanning several length scales from nanometer to centimeter sizes. Depending each time on the desired properties of the composite material, optimization with respect to its stiffness, weight, density, toughness and other pro",{"id":122,"funder":7,"programme":8,"title":123,"piName":10,"institution":90,"country":80,"year":13,"amount":124,"abstract":125},"cordis-european-research-council-award-637748","Fluid transport at the nano- and meso- scales : from fundamentals to applications in energy harvesting and desalination process","€1,494,000","New models of fluid transport are expected to emerge from the confinement of liquids at the nanoscale, where the behaviour of matter strongly departs from common expectations. This is the field of the Nanofluidics : taking inspiration from the solution found by evolved biological systems, new functionalities will emerge from the nanometre scale, with potential applications in ultrafiltration, desalination and energy conversion.Nevertheless, advancing our fundamental understanding of fluid transp",{"id":127,"funder":7,"programme":8,"title":128,"piName":10,"institution":129,"country":80,"year":13,"amount":130,"abstract":131},"cordis-european-research-council-award-637503","High precision isotopic measurements of heavy elements in extra-terrestrial materials: origin and age of the solar system volatile element depletion","INSTITUT DE PHYSIQUE DU GLOBE DE PARIS","€1,487,500","The objectives of this proposal, PRISTINE (high PRecision ISotopic measurements of heavy elements in extra-Terrestrial materials: origIN and age of the solar system volatile Element depletion), are to develop new cutting edge high precision isotopic measurements to understand the origin of the Earth, Moon and solar system volatile elements and link their relative depletion in the different planets to their formation mechanism. In addition, the understanding of the origin of the volatile elements",{"id":133,"funder":7,"programme":8,"title":134,"piName":10,"institution":90,"country":80,"year":13,"amount":56,"abstract":135},"cordis-european-research-council-award-639706","Ecophysiological and biophysical constraints on domestication in crop plants","A fundamental question in biology is how constraints drive phenotypic changes and the diversification of life. We know little about the role of these constraints on crop domestication, nor how artificial selection can escape them. CONSTRAINTS questions whether crop domestication has shifted ecophysiological and biophysical traits related to resource acquisition, use and partitioning, and how trade-offs between them have constrained domestication and can limit future improvements in both optimal ",{"id":137,"funder":7,"programme":8,"title":138,"piName":10,"institution":90,"country":80,"year":13,"amount":10,"abstract":139},"cordis-european-research-council-award-637815","QUantum Hall Edge State Tunnelling spectroscopy","The quantum nature of an electronic fluid is ubiquitous in many solid-state systems subjected to correlations or confinement. This is particularly true for two-dimensional electron gases (2DEGs) in which fascinating quantum states of matter, such as the integer and fractional quantum Hall (QH) states, arise under strong magnetic fields. The understanding of QH systems relies on the existence of one-dimensional (1D) conducting channels that propagate unidirectionally along the edges of the system",{"id":141,"funder":7,"programme":8,"title":142,"piName":10,"institution":143,"country":80,"year":13,"amount":144,"abstract":145},"cordis-european-research-council-award-639888","Modeling and treating retinal degenerative disease","SORBONNE UNIVERSITE","€1,300,000","Gene therapy using adeno-associated viral (AAV) vectors has shown early promise in clinical trials. The therapeutic transgene cassette can be packaged in different AAV capsid pseudotypes, each having a unique transduction profile. At present, AAV capsid serotype selection for a specific clinical trial is based on effectiveness in small animal models. We (and others) have shown substantial progress in improving gene therapy for eye diseases in rodents. However, small animal studies are not often ",{"id":147,"funder":7,"programme":8,"title":148,"piName":10,"institution":149,"country":150,"year":13,"amount":51,"abstract":151},"cordis-european-research-council-award-638730","Development of functional organization of the visual circuits in mice","AARHUS UNIVERSITET","DK","The key organizing principles that characterize neuronal systems include asymmetric, parallel, and topographic connectivity of the neural circuits. The main aim of my research is to elucidate the key principles underlying functional development of neural circuits by focusing on those organizing principles. I choose mouse visual system as my model since it contains all of these principles and provides sophisticated genetic tools to label and manipulate individual circuit components. My research i",{"id":153,"funder":7,"programme":8,"title":154,"piName":10,"institution":155,"country":150,"year":13,"amount":156,"abstract":157},"cordis-european-research-council-award-639904","Reducing empiricism in luminescence geochronology: Understanding the origins of luminescence from individual sand grains","DANMARKS TEKNISKE UNIVERSITET","€1,314,963","Sediments preserve a history of the evolution of the Earth’s surface and its response to a changing climate – a history that can only be read reliably if we know the age of the sediments. Luminescence dating is widely used in quaternary geology and archaeology, and is applicable to almost all sediments from the last 0.5 Ma – it dates the last time the sediment grains were exposed to daylight. RELOS will improve the reliability of luminescence dating by determining the sources of unexpected sprea",{"id":159,"funder":7,"programme":8,"title":160,"piName":10,"institution":149,"country":150,"year":13,"amount":161,"abstract":162},"cordis-european-research-council-award-639560","Measurement-based dynamic control of mesoscopic many-body systems","€1,499,406","Quantum control is an ambitious framework for steering dynamics from initial states to arbitrary desired final states. It has over the past decade been used extensively with immense success for control of low- dimensional systems in as varied fields as molecular dynamics and quantum computation. Only recently have efforts been initiated to extend this to higher-dimensional many-body systems. Most generic quantum control schemes to date, however, put quite heavy requirements on the controllabilit",{"id":164,"funder":7,"programme":8,"title":165,"piName":10,"institution":166,"country":27,"year":13,"amount":167,"abstract":168},"cordis-european-research-council-award-637394","Design, Synthesis, Characterization and Catalytic Application of Silyliumylidene Ions","TECHNISCHE UNIVERSITAET MUENCHEN","€1,499,942","This ERC-StG 2014 proposal, SILION, outlines a strategy for the one-pot synthesis, characterization, and reactivity investigation of a positively charged, electron-deficient, highly Lewis acidic, cationic silicon(II) species, denoted “silyliumylidene ions”. Silyliumylidene ion has only four valence electrons, consisting of a lone pair of electrons and two vacant orbitals on the central silicon atom. It will be expected to bear the best combined character of both silylenes as silicon analogue of ",{"id":170,"funder":7,"programme":8,"title":171,"piName":10,"institution":166,"country":27,"year":13,"amount":172,"abstract":173},"cordis-european-research-council-award-637472","Neural processing of context-dependent innate behavior","€1,497,600","How do we decide what to choose? While certain cues are preferred, others are avoided. But even innate preferences and aversions must be evaluated in a context-dependent manner. These contexts are environmental cues, but also internal state. In this proposal, I will address how the nervous system integrates chemosensory information with internal state to produce appropriate behaviors. I will present a research program relying on fly genetics, behavior analysis, and in vivo physiology to characte",{"id":175,"funder":7,"programme":8,"title":176,"piName":10,"institution":177,"country":27,"year":13,"amount":178,"abstract":179},"cordis-european-research-council-award-637164","Individualized treatment planning in chronic back pain patients by advanced imaging and multi-parametric biomechanical models","KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)","€1,493,492","Chronic back pain is a major burden and source of disability worldwide. It is primarily attributed to biomechanical factors. In elderly patients, osteoporosis complicates the biomechanical scenario. Surgery is often required to treat instability-related pain and to restore the balance of the spine. However, when and how to perform surgery remains a highly subjective decision based on the surgeon’s experience, with 2\u002F3 of patients experiencing prolonged pain.We recently established objective, ima",{"id":181,"funder":7,"programme":8,"title":182,"piName":10,"institution":183,"country":27,"year":13,"amount":184,"abstract":185},"cordis-european-research-council-award-637756","Steering attosecond electron dynamics in biomolecules with UV-XUV LIGHT pulses","DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY","€1,497,000","One of the challenges facing science is to understand the chemical origin of DNA damage-induced mutations. Upon exposure to UV light, DNA nucleobases become electronically excited. This process potentially favors mutagenic miscoding of the DNA sequence.The main target of STARLIGHT is to study with unprecedented temporal resolution (few-femtoseconds\u002Fattoseconds) the electron dynamics occurring in UV photoexcited biomolecules. I will mainly consider aromatic complexes including DNA nucleobases (an",{"id":187,"funder":7,"programme":8,"title":188,"piName":10,"institution":189,"country":80,"year":13,"amount":190,"abstract":191},"cordis-european-research-council-award-640151","A mimetic implant for low perturbation, stable stimulation and recording of neural units inside the brain.","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","€1,499,850","Developing brain implants is crucial to better decipher the neuronal information and intervene in a very thin way on neural networks using microstimulations. This project aims to address two major challenges: to achieve the realization of a highly mechanically stable implant, allowing long term connection between neurons and microelectrodes and to provide neural implants with a high temporal and spatial resolution. To do so, the present project will develop implants with structural and mechanica",{"id":193,"funder":7,"programme":8,"title":194,"piName":10,"institution":189,"country":80,"year":13,"amount":51,"abstract":195},"cordis-european-research-council-award-637579","Autonomous Cellular Computers for Diagnosis","Early diagnostics based on multiple biomarkers is key in numerous diseases, yet current technologies for multiplexed detection are complicated and expensive. Living cells detect and process various environmental signals in parallel and can self-replicate, presenting an attractive platform for scalable and affordable autonomous diagnostic devices. In this project, I will apply my expertise in synthetic biology, the rational engineering of biological systems, to build cell-based biosensors for mul",{"id":197,"funder":7,"programme":8,"title":198,"piName":10,"institution":189,"country":80,"year":13,"amount":51,"abstract":199},"cordis-european-research-council-award-639737","Amyotrophic Lateral Sclerosis from a cortical perspective: towards alternative therapeutic strategies","Amyotrophic Lateral Sclerosis (ALS) is the most common adult-onset neurodegenerative disease of the motor system, with a prevalence of 2-3\u002F100 000. In spite of intensive research efforts, ALS remains an incurable disease and presents with a very severe prognosis, leading to patient death within 2 to 5 years following diagnosis.At the cellular level, ALS is characterized by the combined degeneration of both upper motor neurons (UMN, or corticospinal motor neurons) whose cell bodies are located in",{"id":201,"funder":7,"programme":8,"title":202,"piName":10,"institution":143,"country":80,"year":13,"amount":203,"abstract":204},"cordis-european-research-council-award-637653","Mathematical study of Boundary Layers in Oceanic Motions","€1,267,500","Boundary layer theory is a large component of fluid dynamics. It is ubiquitous in Oceanography, where boundary layer currents, such as the Gulf Stream, play an important role in the global circulation. Comprehending the underlying mechanisms in the formation of boundary layers is therefore crucial for applications. However, the  treatment of boundary layers in ocean dynamics  remains poorly understood at a theoretical level, due to the variety and complexity of the forces at stake. The goal of t",{"id":206,"funder":7,"programme":8,"title":207,"piName":10,"institution":143,"country":80,"year":13,"amount":208,"abstract":209},"cordis-european-research-council-award-637770","Water-mass transformation and Pathways In The Weddell Sea: uncovering the dynamics of a global climate chokepoint from In-situ measurements","€1,998,125","Deep water formed around the Antarctic continent drives the world ocean circulation. 50-70% of this deep water is formed within only about 10% of the Antarctic circumpolar band: the Weddell Sea. Subtle changes in the circulation of the Weddell Sea can lead to major changes in floating ice-shelves, with critical implications for global sea-level, the production of deep water and the global ocean overturning circulation. Despite these critical climate implications, the Antarctic shelf circulation ",{"id":211,"funder":7,"programme":8,"title":212,"piName":10,"institution":213,"country":12,"year":13,"amount":214,"abstract":215},"cordis-european-research-council-award-638259","Intimate Encounters in EU Borderlands: Migrant Maternity, Sovereignty and the Politics of Care on Europe’s Peripheries","ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA","€1,498,463","EU Border Care is a comparative study of the politics of maternity care among undocumented migrants on the EU’s peripheries. Empirical analysis of personal and institutional relations of care and control in the context of pregnancy and childbirth will support an innovative critique of the moral rationale underpinning healthcare delivery and migration governance in some of Europe’s most densely crossed borderlands in France, Greece, Italy and Spain.Unlike other categories of migrants, undocumente",{"id":217,"funder":7,"programme":8,"title":218,"piName":10,"institution":213,"country":12,"year":13,"amount":219,"abstract":220},"cordis-european-research-council-award-638992","Distributed Optimization Methods for Smart Cyber-Physical Networks","€1,488,750","The combination of embedded electronics and communication capability in almost any mobile or portable device has turned this century into the age of cyber-physical networks. Smart communicating devices with their sensing, computing and control capabilities promise to make our cities, transportation systems, factories and living environments more intelligent, energy-efficient, safe and secure. This extremely complex system has raised a number of new challenges involving ICT disciplines. In partic",{"id":222,"funder":7,"programme":8,"title":223,"piName":10,"institution":50,"country":20,"year":13,"amount":224,"abstract":225},"cordis-european-research-council-award-633152","Geometric problems in PDEs with applications to fluid mechanics","€1,256,375","There are many high-profile problems in PDEs that ultimately boil down to assertions of a strongly geometric or topological nature. One feature that makes these problems both very difficult and extremely appealing is that there is not a standard set of techniques that one can routinely resort to in order to attack them. Indeed, the very nature of these questions makes them strongly interdisciplinary, so successful approaches require finely tailored combinations of ideas and techniques coming fro",{"id":227,"funder":7,"programme":8,"title":228,"piName":10,"institution":50,"country":20,"year":13,"amount":229,"abstract":230},"cordis-european-research-council-award-638553","Integrating genomics, epidemiology and evolution to accelerate tuberculosis eradication","€1,671,875","When the scale of the tuberculosis (TB) epidemic was highlighted by its declaration as a Global Emergency by WHO in 1993, it was envisaged that the efficient use of existing tools would result in a progressive decline towards eradication. This has not occurred. At the current pace of decline in TB incidence the Millennium objective to eradicate it by 2050 will not be met. Predictions of epidemiological models were inaccurate and current control programs and technologies have shown their limitati",{"id":232,"funder":7,"programme":8,"title":233,"piName":10,"institution":33,"country":34,"year":13,"amount":234,"abstract":235},"cordis-european-research-council-award-638009","Integrated and Detailed Image Understanding","€1,497,271","The aim of this project is to create the technology needed to understand the content of images in a detailed, human-like manner, significantly superseding the current limitations of automatic image understanding, and enabling new far reaching human-centric applications. The first goal is to substantially broaden the spectrum of visual information that machines can extract from images. For example, where current technology may discover that there is a ``person'' in an image, we would like to prod",{"id":237,"funder":7,"programme":8,"title":238,"piName":10,"institution":33,"country":34,"year":13,"amount":239,"abstract":240},"cordis-european-research-council-award-637765","Characterising the Gene Regulatory Networks Governing Photosynthesis: From Basic Understanding to Targeted Engineering","€1,482,363","Photosynthesis underpins life on earth. Despite its fundamental importance, our knowledge of the molecular regulators that control the expression of photosynthetic genes is limited, and only four transcription factors are known to regulate the expression of cohorts of photosynthetic genes in plants.  This project aims to address this knowledge gap by identifying and characterising the molecular regulators that control the expression of photosynthetic genes. This aim will be achieved through an i",{"id":242,"funder":7,"programme":8,"title":243,"piName":10,"institution":33,"country":34,"year":13,"amount":244,"abstract":245},"cordis-european-research-council-award-638435","Astrophysical Dynamics and Statistical Physics of Galactic Nuclei","€1,511,436","We address some of the major unsolved questions of galactic nuclei using methods of condensed matter physics. Galactic nuclei host a central supermassive black hole, a dense population of stars and compact objects, and in many cases a bright gaseous disk feeding the supermassive black hole. The observed stellar distribution exhibits both spherical and counterrotating disk-like structures. Existing theoretical models cannot convincingly explain the origin of the stellar disks. Is there also a “da",{"id":247,"funder":7,"programme":8,"title":248,"piName":10,"institution":33,"country":34,"year":13,"amount":249,"abstract":250},"cordis-european-research-council-award-637334","Geometry and Anomalous Dynamic Growth of Elastic instabiliTies","€1,361,077","Elastic instabilities are ubiquitous, from the wrinkles that form on skin to the ‘snap-through’ of an umbrella on a windy day. The complex patterns such instabilities make, and the great speed with which they develop, have led to a host of technological and scientific applications. However, recent experiments have revealed significant gaps in our theoretical understanding of such instabilities, particularly in the roles played by geometry and dynamics. I will establish a group to develop and val",{"id":252,"funder":7,"programme":8,"title":253,"piName":10,"institution":90,"country":80,"year":13,"amount":254,"abstract":255},"cordis-european-research-council-award-639003","Dynamic Earth Evolution and Paleogeography through Tomographic Imaging of the Mantle","€1,438,846","DEEP TIME will unearth a record of geological time that is buried thousands of kilometres deep. The seafloor that covers two-thirds of the earth's surface is a tiny fraction of all seafloor created during its history – the rest has sunk back into the viscous mantle. Slabs of subducted seafloor carry a record of surface history: how continents and oceans were configured over time and where their tectonic plate boundaries lay. DEEP TIME will follow former surface oceans as far back in time as the ",{"id":257,"funder":7,"programme":8,"title":258,"piName":10,"institution":33,"country":34,"year":13,"amount":259,"abstract":260},"cordis-european-research-council-award-637713","Coevolutionary Policy Search","€1,480,632","I propose to develop a new class of decision-theoretic planning methods that overcome fundamental obstacles to the efficient optimization of autonomous agents.  Creating agents that are effective in diverse settings is a key goal of artificial intelligence with enormous potential implications: robotic agents would be invaluable in homes, factories, and high-risk settings; software agents could revolutionize e-commerce, information retrieval, and traffic control.The main challenge lies in specify",{"id":262,"funder":7,"programme":8,"title":263,"piName":10,"institution":264,"country":265,"year":13,"amount":266,"abstract":267},"cordis-european-research-council-award-639313","Quantitative Nanoscale Visualization of Macromolecular Complexes in Live Cells using Genetic Code Expansion and High-Resolution Imaging","BEN-GURION UNIVERSITY OF THE NEGEV","IL","€1,625,000","High-resolution fluorescence imaging, including super-resolution microscopy and high-speed live cell imaging, are used to obtain quantitative information on the structural organization and kinetics of cellular processes. The contribution of these high-resolution techniques to cell biology was recently demonstrated for dynamin- and ESCRT-driven membrane fission in cells. While they advance our knowledge on membrane fission these techniques do not provide the quantitative information needed to for",{"id":269,"funder":7,"programme":8,"title":270,"piName":10,"institution":271,"country":265,"year":13,"amount":51,"abstract":272},"cordis-european-research-council-award-638142","Unraveling changes in cellular gene expression during viral infection","WEIZMANN INSTITUTE OF SCIENCE","The herpesvirus human cytomegalovirus (HCMV) infects the majority of the world's population, leading to severe diseases in millions of newborns and immunocompromised adults annually. During infection, HCMV extensively manipulates cellular gene expression to maintain conditions favorable for efficient viral propagation. Identifying the pathways that the virus relies on or subverts is of great interest as they have the potential to provide new therapeutic windows and reveal novel principles in cel",{"id":274,"funder":7,"programme":8,"title":275,"piName":10,"institution":271,"country":265,"year":13,"amount":51,"abstract":276},"cordis-european-research-council-award-637878","Sequence and Function Relationships in Long Intervening Noncoding RNAs","It is now clear that many intergenic regions in eukaryotic genomes give rise to a range of processed and regulated transcripts that do not appear to code for functional proteins. A subset of these are long (>200 nt), capped and polyadenylated RNAs transcribed by RNA polymerase II and collectively called long intervening noncoding RNAs or lincRNAs. The recent estimates are that the human genome encodes >10,000 distinct lincRNAs, many of which show tissue-specific expression and are frequently dys",{"id":278,"funder":7,"programme":8,"title":279,"piName":10,"institution":280,"country":150,"year":13,"amount":10,"abstract":281},"cordis-european-research-council-award-638273","A systematic characterization of human regulatory architectures and their determinants of regulatory activity","KOBENHAVNS UNIVERSITET","Enhancers control the correct spatio-temporal activation of gene expression. A comprehensive characterization of the properties and regulatory activities of enhancers as well as their target genes is therefore crucial to understand the regulation and dysregulation of differentiation, homeostasis and cell type specificity.Genome-wide chromatin assays have provided insight into the properties and complex architectures by which enhancers regulate genes, but the understanding of their mechanisms is ",{"id":283,"funder":7,"programme":8,"title":284,"piName":10,"institution":285,"country":286,"year":13,"amount":287,"abstract":288},"cordis-european-research-council-award-636855","Common Oncogenic Mechanisms in Multi-Partner Translocation Families in Acute Myeloid Leukemia","VETERINAERMEDIZINISCHE UNIVERSITAET WIEN","AT","€1,499,500","Acute Myeloid Leukemia (AML) is the most frequent cancer of the blood system, with >80% mortality within 5 years of diagnosis. Straightforward clinical decisions are complicated by the genetic complexity of AML. In particular, fusion proteins arising from chromosomal aberrations are recurrently found in AML and often act as strong driver oncogenes. In “Multi-Partner Translocation” (MPT) families, one specific gene is fused to many recipient loci. Due to this modular architecture, MPT families ar",{"id":290,"funder":7,"programme":8,"title":291,"piName":10,"institution":292,"country":293,"year":13,"amount":294,"abstract":295},"cordis-european-research-council-award-640116","Environmental modulators of the immune cell balance in health and disease","VIB VZW","BE","€1,499,041","The incidence of autoimmune diseases in developed societies is increasing at high rates, but the underlying cause for this phenomenon has not been elucidated yet. Since the genetic architect remains considerably stable, this increase is likely associated with changes in the environment. Autoimmunity is linked to an imbalance of pro-inflammatory Th17 cells and anti-inflammatory Foxp3+ regulatory T cells (Treg). However, little is known regarding environmental factors that influence the Th17\u002FTreg ",{"id":297,"funder":7,"programme":8,"title":298,"piName":10,"institution":299,"country":300,"year":13,"amount":51,"abstract":301},"cordis-european-research-council-award-637422","Computational Analysis of Everyday Soundscapes","TAMPEREEN KORKEAKOULUSAATIO SR","FI","Sounds carry a large amount of information about our everyday environment and physical events that take place in it. For example, when a car is passing by, one can perceive the approximate size and speed of the car. Sound can easily and unobtrusively be captured e.g. by mobile phones and transmitted further – for example, tens of hours of audio is uploaded to the internet every minute e.g. in the form of YouTube videos. However, today's technology is not able to recognize individual sound source",{"id":303,"funder":7,"programme":8,"title":304,"piName":10,"institution":305,"country":27,"year":13,"amount":306,"abstract":307},"cordis-european-research-council-award-637367","Hybrid Node Modes for Highly Efficient Light Concentrators","BERGISCHE UNIVERSITAET  WUPPERTAL","€1,485,000","The meaning of solar energy for future decentralized power supply will largely depend on both efficiency and cost of solar to electrical power conversion. All kinds of conversion strategies including photovoltaics, concentrated solar power, solar to fuel and others would benefit from efficiently collecting solar power on large areas. For this reason luminescent solar concentrators have been developed for over thirty years, but due to waveguide losses their maximum size is still limited to a few ",{"id":309,"funder":7,"programme":8,"title":310,"piName":10,"institution":311,"country":286,"year":13,"amount":312,"abstract":313},"cordis-european-research-council-award-640156","High-level Prior Models for Computer Vision","TECHNISCHE UNIVERSITAET GRAZ","€1,473,525","Since more than 50 years, computer vision has been a very active research field but it is still far away from the abilities of the human visual system. This stunning performance of the human visual system can be mainly contributed to a highly efficient three-layer architecture: A low-level layer that sparsifies the visual information by detecting important image features such as image gradients, a mid-level layer that implements disocclusion and boundary completion processes and finally a high-l",{"id":315,"funder":7,"programme":8,"title":316,"piName":10,"institution":271,"country":265,"year":13,"amount":317,"abstract":318},"cordis-european-research-council-award-637912","Relative representation theory and distributions  on reductive groups over local fields","€1,196,215","One can view the representation theory of a topological group as non-commutative harmonic analysis on the group. For compact groups this view is justified by the Peter-Weyl theorem. The relative representation theory of a group is harmonic analyses on spaces with transitive group action.I work in relative representation theory of reductive (algebraic) groups over local fields, e.g. the general linear group over the  field of real numbers or the  field of p-adic numbers. This theory has applicati",{"id":320,"funder":7,"programme":8,"title":321,"piName":10,"institution":322,"country":265,"year":13,"amount":323,"abstract":324},"cordis-european-research-council-award-635537","Exploiting light and material interaction","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","€1,999,825","The interaction between light and material leads to beautiful visual phenomena that greatly enrich our perception of the world.  The ability to measure and model light scattering is central to almost any field of science. However, light transport in rich scenes is a complex process involving a long sequence of scattering events. Computationally modeling, reproducing and acquiring the processes generated so easily by Mother Nature is an extremely challenging task.  While several computational mod",{"id":326,"funder":7,"programme":8,"title":327,"piName":10,"institution":328,"country":27,"year":13,"amount":10,"abstract":329},"cordis-european-research-council-award-639766","Transgenerational transmission of maternal childhood trauma and its sequelae – Altered maternal physiology during pregnancy and implications for newborn neurodevelopment","CHARITE - UNIVERSITAETSMEDIZIN BERLIN","Alarming statistics in a recent report by the EU Agency for Fundamental Rights suggest that 1 in 3 women have experienced physical or sexual violence in childhood. The sequelae of childhood trauma (CT) exposure include psychopathology, altered stress physiology, obesity, and increased likelihood of exposure to violence in adulthood. Also, emerging evidence suggests the long shadow cast by CT may be transmitted to the offspring of exposed individuals, who have a higher prevalence of psychiatric d",{"id":331,"funder":7,"programme":8,"title":332,"piName":10,"institution":333,"country":150,"year":13,"amount":334,"abstract":335},"cordis-european-research-council-award-639383","Risky Decisions: Revealing Economic Behaviour","COPENHAGEN BUSINESS SCHOOL","€1,461,881","Households are exposed to a wide array of monetary and non-monetary risks: employment risk, financial risk, interest rate risk, and health and mortality risk, to name a few. Society and policymakers can certainly help households manage risk, but to be effective, they need to understand the ways households cope with risk and how vulnerable they are to market and policy changes. For instance, how do households react to bank defaults and market failures? How personal do these experiences have to be",{"id":337,"funder":7,"programme":8,"title":338,"piName":10,"institution":339,"country":293,"year":13,"amount":340,"abstract":341},"cordis-european-research-council-award-639784","Dynamic interplay between DNA methylation, histone modifications and super enhancer activity in normal T cells and during malignant T cell transformation","UNIVERSITEIT GENT","€958,750","Dynamic interplay between histone modifications and DNA methylation defines the chromatin structure of the humane genome and serves as a conceptual framework to understand transcriptional regulation in normal development and human disease. The ultimate goal of this research proposal is to study the chromatin architecture during normal and malignant T cell differentiation in order to define how DNA methylation drives oncogenic gene expression as a novel concept in cancer research.T-cell acute lym",{"id":343,"funder":7,"programme":8,"title":344,"piName":10,"institution":345,"country":62,"year":13,"amount":51,"abstract":346},"cordis-european-research-council-award-638030","Stem Cells for Cardiac Arrhythmia Risk Assessment","ACADEMISCH ZIEKENHUIS LEIDEN","Among the most significant conceptual changes in stem cell biology of the past decade has been the use of human pluripotent stem cells (hPSCs) for disease modelling and drug development rather than solely as therapeutics. One area of major interest in this context is that of arrhythmic disorders of the heart. Cardiac arrhythmias are a leading cause of death among young people, with inherited forms affecting as many as 1 in 2000. Even more prevalent are acquired arrhythmias due to adverse respons",{"id":348,"funder":7,"programme":8,"title":349,"piName":10,"institution":350,"country":20,"year":13,"amount":351,"abstract":352},"cordis-european-research-council-award-638028","Epistasis analysis of angiogenes with high cellular definition","CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)","€1,481,375","Blood and lymphatic vessels have been the subject of intense investigation due to their important role in cancer development and in cardiovascular diseases. The significant advance in the methods used to modify and analyse gene function have allowed us to obtain a much better understanding of the molecular mechanisms involved in the regulation of the biology of blood vessels. However, there are two key aspects that significantly diminish our capacity to understand the function of gene networks a",{"id":354,"funder":7,"programme":8,"title":355,"piName":10,"institution":356,"country":357,"year":13,"amount":358,"abstract":359},"cordis-european-research-council-award-637843","Molecular control of self-renewal and lineage specification in thymic epithelial cell progenitors in vivo.","INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC","PT","€1,491,749","The development of vaccines for the treatment of infectious diseases, cancer and autoimmunity depends on our knowledge of T-cell differentiation. This proposal is focused on studying the thymus, the organ responsible for the generation of T cells that are responsive against pathogen-derived antigens, and yet tolerant to self. Within the thymus, thymic epithelial cells (TECs) provide key inductive microenvironments for the development and selection of T cells that arise from hematopoietic progeni",{"id":361,"funder":7,"programme":8,"title":362,"piName":10,"institution":363,"country":34,"year":13,"amount":364,"abstract":365},"cordis-european-research-council-award-637638","Optogenetic investigation of cortical layer-6 neuron contributions to dynamic visual perception","UNIVERSITY OF NEWCASTLE UPON TYNE","€1,405,000","In order to achieve a more complete understanding of neocortical brain functions in health and disease, we need to delineate the computations of specific cell populations and how they dynamically exert their impact on connected target neurons. Here, I propose to investigate the functions of neurons in layer-6 of primary visual cortex (V1) and their influence on connected neurons, i) in the lateral geniculate nucleus (LGN) of thalamus, and ii) to more superficially located V1 cells, during visual",{"id":367,"funder":7,"programme":8,"title":368,"piName":10,"institution":369,"country":34,"year":13,"amount":370,"abstract":371},"cordis-european-research-council-award-640012","Advanced Bioderived and Biocompatible Lasers","THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS","€1,499,875","Naturally occurring optical phenomena attract great attention and transform our ability to study biological processes, with “the discovery and development of the green fluorescent protein (GFP)” (Nobel Prize in Chemistry 2008) being a particularly successful example. Although found only in very few species in nature, most organisms can be genetically programmed to produce the brightly fluorescent GFP molecules. Combined with modern fluorescence detection schemes, this has led to entirely new way",{"id":373,"funder":7,"programme":8,"title":374,"piName":10,"institution":375,"country":27,"year":13,"amount":376,"abstract":377},"cordis-european-research-council-award-638897","DNA end protection in Immunity and Cancer","MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)","€1,993,421","This proposal addresses a fundamental issue in molecular biology: how is repair of DNA double-strand breaks (DSBs) steered towards the appropriate physiological outcome? DSBs are cytotoxic DNA lesions that arise as a by-product of DNA replication, but also as a physiological intermediate during antigen receptor diversification in the Immune system. DNA end processing is a major determinant of DSB repair outcome. Resection of DNA ends is a prerequisite for physiological repair of replication-asso",{"id":379,"funder":7,"programme":8,"title":380,"piName":10,"institution":381,"country":300,"year":13,"amount":382,"abstract":383},"cordis-european-research-council-award-637991","Computational User Interface Design","AALTO KORKEAKOULUSAATIO SR","€1,499,790","PROBLEM: Despite extensive research on human-computer interaction (HCI), no method exists that guarantees the optimal or even a provably good user interface (UI) design. The prevailing approach relies on heuristics and iteration, which can be costly and even ineffective, because UI design often involves combinatorially hard problems with immense design spaces, multiple objectives and constraints, and complex user behavior.OBJECTIVES: COMPUTED establishes the foundations for optimizing UI designs",{"id":385,"funder":7,"programme":8,"title":386,"piName":10,"institution":387,"country":20,"year":13,"amount":388,"abstract":389},"cordis-european-research-council-award-640525","How to regenerate the mammalian kidney","FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA","€1,499,604","Kidney non-endocrine functions are primarily performed by millions of individual integral units called nephrons. Although the adults of simple vertebrates (fish, amphibians and reptiles) have the ability to regenerate entire nephrons by a process called “nephron neogenesis”, this capacity is absent in birds and mammals. In this regard we have observed, for the first time, that the murine neonatal kidney is able to generate new nephrons after the resection of the 20 per cent of the kidney mass. I",{"id":391,"funder":7,"programme":8,"title":392,"piName":10,"institution":393,"country":27,"year":13,"amount":370,"abstract":394},"cordis-european-research-council-award-638278","Structure-Property Relations in Aqueous Foam and Their Control on a Molecular Level","UNIVERSITAET MUENSTER","Foams are of enormous importance as we find them in many technological relevant applications and food products. Foams as hierarchical materials are dominated by the arrangement and distri-bution of gas bubbles on a macroscopic scale, as well as by thickness and composition of lamella on a mesoscopic scale. Liquid-gas interfaces are, however, the building block of foam with over-whelming importance as their molecular properties easily dominate hierarchical elements on larger length scales. In ord",{"id":396,"funder":7,"programme":8,"title":397,"piName":10,"institution":398,"country":20,"year":13,"amount":399,"abstract":400},"cordis-european-research-council-award-639643","Frontiers of Quantum Atom-Light Interactions","FUNDACIO INSTITUT DE CIENCIES FOTONIQUES","€1,340,873","FoQAL aims to completely re-define our ability to control light-matter interactions at the quantum level. This potential revolution will make use of cold atoms interfaced with nanophotonic systems, exploiting unique features such as control over the dimensionality and dispersion of light, the engineering of quantum vacuum forces, and strong optical fields and forces associated with light confined to the nanoscale. We will develop powerful and fundamentally new paradigms for atomic trapping, tail",{"id":402,"funder":7,"programme":8,"title":403,"piName":10,"institution":404,"country":34,"year":13,"amount":405,"abstract":406},"cordis-european-research-council-award-638605","Sensory Experiences for Interactive Technologies","UNIVERSITY COLLEGE LONDON","€1,494,865","The senses we call upon to interact with technology are still very limited relying mostly on visual and auditory senses. The grand challenge and vision of this project is to gain a rich and integrated understanding on touch, taste, and smell experiences for interactive technologies.We aim to achieve this ambitious grand vision by 1) creating a ‘sensory interaction framework’ on the bases of a systematic empirical investigation of touch, taste, and smell experiences, 2) integrating the generated ",{"id":408,"funder":7,"programme":8,"title":409,"piName":10,"institution":410,"country":34,"year":13,"amount":10,"abstract":411},"cordis-european-research-council-award-638957","Information Technology and Institutions Supporting Human Capital Accumulation and Exchange","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","Information technology revolutions transform the production and exchange of ideas and drive profound institutional and cultural change. History provides unique settings to document the causal impact of changes in information technology and institutions, and the best evidence on their long-run effects.The objective of the research is to document the impact of revolutionary transformations in information technology and institutions using evidence from the European Renaissance. Printing was the new",{"id":413,"funder":7,"programme":8,"title":414,"piName":10,"institution":410,"country":34,"year":13,"amount":415,"abstract":416},"cordis-european-research-council-award-639744","Market Beliefs and Optimal Policy in the Presence of Disasters","€1,287,755","My proposal consists of two strands linked by a common theme--namely a concern for the impact of disasters, in financial markets and more generally--and by a shared methodology.In the first of these strands, I propose to develop ways of using observable asset price data to infer the beliefs of market participants about various quantities that are central to financial economics, including (i) the equity premium; (ii) the forward-looking autocorrelation of the market (i.e., time-series momentum); ",{"id":418,"funder":7,"programme":8,"title":419,"piName":10,"institution":410,"country":34,"year":13,"amount":420,"abstract":421},"cordis-european-research-council-award-639633","Multinationals, Institutions and Innovation in Europe","€1,276,880","Multinational Enterprises (MNEs) are key ‘tectonic forces’, shaping the ‘mountains’ in a far-from-flat world economic geography. In 2010, MNEs generated value added for approximately US$16 trillion accounting for more than a quarter of world GDP (UNCTAD, 2012). The progessive expansion of firms from emerging economies into multinational enterprises is unprecedented. Outflows of FDIs from developing economies reached the record level of $426 billion in 2012, corresponding to 31% of global outflow",{"id":423,"funder":7,"programme":8,"title":424,"piName":10,"institution":61,"country":62,"year":13,"amount":425,"abstract":426},"cordis-european-research-council-award-639221","Extreme deformation of structured fluids and interfaces. Exploiting ultrafast collapse and yielding phenomena for new processes and formulated products","€1,499,186","The increasing demand for environmentally friendly, healthier, and better performing formulated products means that the process industry needs more than ever predictive models of formulation performance for rapid, effective, and sustainable screening of new products. Processing flows and end use produce deformations that are extreme compared to what is accessible with existing experimental methods. As a consequence, the effects of extreme deformation are often overlooked without justification.Ex",{"id":428,"funder":7,"programme":8,"title":429,"piName":10,"institution":430,"country":34,"year":13,"amount":431,"abstract":432},"cordis-european-research-council-award-639485","Quantitative developmental genetic analysis of phenotypic buffering and cryptic variation","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€1,499,745","Randomness pervades life and biological systems are continuously subject to variation. This variation may be stochastic, due to random fluctuations in the concentration of critical molecules, genetic, due to mutation accumulation, or environmental, because of changes in the environment over time. It is therefore remarkable how biological systems manage to operate with so much precision. The property of a system to produce an invariant output in the presence of considerable noise is called robust",{"id":434,"funder":7,"programme":8,"title":435,"piName":10,"institution":430,"country":34,"year":13,"amount":436,"abstract":437},"cordis-european-research-council-award-639750","Vibronic control of organic electronic devices","€1,497,257","Organic electronics (OE) is an expanding research field that exploits the electronic functionalities of organic molecules to make them robust and cost-efficient building blocks for future electronic devices. Due to the ‘soft’ character of organic materials, their electronic properties are defined by vibronic coupling (VC) phenomena which are a result of the interaction between electron and nuclear dynamics of the molecule.This research program aims to unlock a new direction of experimental studi",{"id":439,"funder":7,"programme":8,"title":440,"piName":10,"institution":90,"country":80,"year":13,"amount":441,"abstract":442},"cordis-european-research-council-award-638656","Spin-orbit mechanism in adaptive magnetization-reversal techniques, for magnetic memory design","€1,476,000","Compared to existing Random Access Memories, the Magnetic RAM (MRAM) has the advantage of being non-volatile. Though the basic requirements for reading and writing a single memory element are fulfilled, the present approach based on Spin Transfer Torque (STT) suffers from an innate lack of flexibility. The solution that I propose is based on the discovery of a novel phenomenon, where instead of transferring spin angular momentum from a neighbouring layer, magnetization reversal is achieved by an",{"id":444,"funder":7,"programme":8,"title":445,"piName":10,"institution":90,"country":80,"year":13,"amount":51,"abstract":446},"cordis-european-research-council-award-637763","Molecular basis of the cross-talk between chronic inflammation and cancer","Cancer related inflammation (CRI) is a well-established hallmark of cancer. We recently demonstrated that the DNA damage repair SLX4 complex suppresses spontaneous and human immunodeficiency virus (HIV)-dependent pro-inflammatory cytokine production, revealing a role for this DNA repair complex in controlling innate immune responses. Bi-allelic mutations in SLX4 are involved in the onset of Fanconi Anemia (FA), a syndrome characterized, besides heightened cancer susceptibility, by severe defects",{"id":448,"funder":7,"programme":8,"title":449,"piName":10,"institution":430,"country":34,"year":13,"amount":450,"abstract":451},"cordis-european-research-council-award-637798","Metabolism of DNA secondary structures and their impact on genome stability","€1,638,041","DNA replication is an essential process for genome duplication, cell division and ultimately organismal survival that ensures faithful transmission of the genome to progeny. Certain genomic loci represent major obstacles to DNA replication including fragile sites, G-rich tracts and repetitive sequences, such as ribosomal DNA and telomeres. Mammalian telomeres have the propensity to adopt complex DNA secondary structures, including telomere-loops and telomeric G-quadruplex DNA, which are believed",{"id":453,"funder":7,"programme":8,"title":454,"piName":10,"institution":430,"country":34,"year":13,"amount":455,"abstract":456},"cordis-european-research-council-award-637304","Innate immune responses to human hepatotropic viral infections","€1,498,312","Chronic hepatotropic infections including hepatitis B (HBV) and C (HCV) are a major public healthconcern. Even though both viruses belong to completely distinct families the pathogenesis they elicit isstrikingly similar, leading to liver fibrosis and cirrhosis. Treatment for HBV and HCV consists of eitherdirect-acting antivirals or pegylated interferon (IFN)α. In contrast to HCV, these treatment regimen are noncurativefor HBV. Little is known to date about the host\u002Fpathogen interactions determin",{"id":458,"funder":7,"programme":8,"title":459,"piName":10,"institution":460,"country":80,"year":13,"amount":461,"abstract":462},"cordis-european-research-council-award-638804","Aneurysmal Arterial Mechanics: Into the Structure","ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS","€1,499,783","The rupture of an Aortic Aneurysm (AA), which is often lethal, is a mechanical phenomenon that occurs when the wall stress state exceeds the local strength of the tissue. Our current understanding of arterial rupture mechanisms is poor, and the physics taking place at the microscopic scale in these collagenous structures remains an open area of research. Understanding, modelling, and quantifying the micro-mechanisms which drive the mechanical response of such tissue and locally trigger rupture r",{"id":464,"funder":7,"programme":8,"title":465,"piName":10,"institution":90,"country":80,"year":13,"amount":51,"abstract":466},"cordis-european-research-council-award-637733","Structural studies of mammalian Cys-loop receptors","In the brain, Cys-loop receptors mediate fast neurotransmission. They function as allosteric signal transducers across the plasma membrane: upon binding of one or more neurotransmitter molecules to an extracellular site, the receptors undergo complex conformational transitions that result in transient opening of an intrinsic ion channel. The Cys-loop family comprises receptors activated by serotonin, acetylcholine, glycine and GABA. Mammalian receptors are also the targets of a legion of psycho-",{"id":468,"funder":7,"programme":8,"title":469,"piName":10,"institution":90,"country":80,"year":13,"amount":10,"abstract":470},"cordis-european-research-council-award-638712","Alzheimer's disease and Zinc: the missing link ?","Alzheimer's disease (AD) is one of the most serious diseases mankind is now facing as its social and economical impacts are increasing fastly. AD is very complex and the amyloid-β (Aβ) peptide as well as metallic ions (mainly copper and zinc) have been linked to its aetiology. While the deleterious impact of Cu is widely acknowledged, intervention of Zn is certain but still needs to be figured out.        The main objective of the present proposal, which is strongly anchored in the bio-inorganic",{"id":472,"funder":7,"programme":8,"title":473,"piName":10,"institution":90,"country":80,"year":13,"amount":474,"abstract":475},"cordis-european-research-council-award-639248","From planetary birth with aperture masking interferometry to nulling with Lithium Niobate technology","€1,851,881","Observing the process of planetary accretion is crucial to inform models of planet formation. Most of the key action is expected to happen in the gaps of protostellar disks – a spatial realm over which aperture masking interferometry has demonstrated a unique ability to deliver incisive imaging. Masking offers twin advantages of higher dynamic range at the diffraction limit (lambda\u002FD) than differential imaging, while at the same time giving nearly complete Fourier coverage compared to long basel",{"id":477,"funder":7,"programme":8,"title":478,"piName":10,"institution":479,"country":80,"year":13,"amount":480,"abstract":481},"cordis-european-research-council-award-637601","Groups, Actions and von Neumann algebras","UNIVERSITE PARIS-SACLAY","€876,750","This research project focuses on the structure, classification and rigidity of three closely related objects: group actions on measure spaces, orbit equivalence relations and von Neumann algebras. Over the last 15 years, the study of interactions between these three topics has led to a process of mutual enrichment, providing both striking theorems and outstanding conjectures.Some fundamental questions such as Connes' rigidity conjecture, the structure of von Neumann algebras associated with high",{"id":483,"funder":7,"programme":8,"title":484,"piName":10,"institution":90,"country":80,"year":13,"amount":485,"abstract":486},"cordis-european-research-council-award-639109","Functional 2D metamaterials at visible wavelengths","€2,000,000","For the last 15 years, optics has undergone a remarkable evolution towards ever decreasing sizes, better integration in complex systems, and more compact devices readily available to mass markets. Whereas traditional optics is at the centimeter scale, newly developed techniques use nanoscale objects to control, guide, and focus light. From the capability to shape metallic and dielectric nanostructures has emerged the field of nanophotonics. Advances in nanophotonics offer the possibility to cont",{"id":488,"funder":7,"programme":8,"title":489,"piName":10,"institution":90,"country":80,"year":13,"amount":490,"abstract":491},"cordis-european-research-council-award-639802","Imaging magnetic fields at the nanoscale with a single spin microscope","€1,498,810","Detecting and imaging magnetic fields with high sensitivity and nanoscale resolution is a topic of crucial importance for a wealth of research domains, from material science, to mesoscopic physics, and life sciences. This is obviously also a key requirement for fundamental studies in nanomagnetism and the design of innovative magnetic materials with tailored properties for applications in spintronics. Although a remarkable number of magnetic microscopy techniques have been developed over the las",{"id":493,"funder":7,"programme":8,"title":494,"piName":10,"institution":90,"country":80,"year":13,"amount":51,"abstract":495},"cordis-european-research-council-award-638376","Building Distinct Actin Filament Networks in a Common Cytoplasm","The ability of cells to use the actin cytoskeleton for a diversity of cellular processes is due to the fact that actin filaments, although assembled from identical subunits, are organized in a wide variety of structures of appropriate geometrical, dynamical and rheological properties. Key players in this regulation are specific sets of actin binding proteins (ABPs) interacting with each actin networks, to modulate spatially and temporally their properties. With this project, I want to understand",{"id":497,"funder":7,"programme":8,"title":498,"piName":10,"institution":479,"country":80,"year":13,"amount":499,"abstract":500},"cordis-european-research-council-award-639107","Chip-scale INtegrated Photonics for the mid-Infra REd","€1,498,125","Mid-infrared (mid-IR) spectroscopy is a nearly universal way to identify chemical and biological substances, as most of the molecules have their vibrational and rotational resonances in the mid-IR wavelength range. Commercially available mid-IR systems are based on bulky and expensive equipment, while lots of efforts are now devoted to the reduction of their size down to chip-scale dimensions. The demonstration of mid-IR photonic circuits on silicon chips will benefit from reliable and high-volu",{"id":502,"funder":7,"programme":8,"title":503,"piName":10,"institution":90,"country":80,"year":13,"amount":10,"abstract":504},"cordis-european-research-council-award-637510","Fourier Analysis For\u002FAnd Partial Differential Equations","This project aims to develop the field of Harmonic Analysis, and more precisely to study problems at the interface between Fourier Analysis and PDEs (and also some Geometry). We are interested in two aspects of the Fourier Analysis : (1) The Euclidean Fourier Analysis, where a deep analysis can be performed using specificities as the notion of ``frequencies'' (involving the Fourier transform) or the geometry of the Euclidean balls. By taking advantage of them, this proposal aims to pursue the st",{"id":506,"funder":7,"programme":8,"title":507,"piName":10,"institution":90,"country":80,"year":13,"amount":508,"abstract":509},"cordis-european-research-council-award-639638","Mesoscopic models for propagation in biology","€1,091,688","According to biologists, there is a need for quantitative models that are able to cope with the complexity of problems arising in the field of life sciences. Here, complexity refers to the interplay between various scales that are not clearly separate. The great challenge of the MESOPROBIO project is to analyse complex PDE models for biological propagation phenomena at the mesoscale. By analogy with the kinetic theory of gases, this is an intermediate level of description between the microscale ",{"id":511,"funder":7,"programme":8,"title":512,"piName":10,"institution":90,"country":80,"year":13,"amount":10,"abstract":513},"cordis-european-research-council-award-638240","Origin and evolution of the sexes and reproductive systems: novel insights from a distant eukaryotic lineage","Sexual reproduction is an extraordinarily widespread phenomenon that assures the production of new genetic combinations in nearly all eukaryotic lineages. Although the core mechanisms of sexual reproduction (meiosis and syngamy) are highly conserved, the control mechanisms that determine whether an individual is male or female are remarkably labile across eukaryotes. In genetically controlled sexual systems, gender is determined by sex chromosomes, which have emerged independently and repeatedly",{"id":515,"funder":7,"programme":8,"title":516,"piName":10,"institution":90,"country":80,"year":13,"amount":10,"abstract":517},"cordis-european-research-council-award-639052","Flexible nanowire devices for energy harvesting","The goal of NanoHarvest is to explore novel solutions for flexible photovoltaic and piezoelectric converters enabled by semiconductor nanowires. The first objective is to demonstrate an innovative concept of flexible solar cells based on free-standing polymer-embedded nanowires which can be applied to almost any supporting material such as plastic, metal foil or even fabrics. The second objective it to develop high-efficiency flexible and compact piezo-generators based on ordered arrays of nanow",{"id":519,"funder":7,"programme":8,"title":520,"piName":10,"institution":521,"country":12,"year":13,"amount":522,"abstract":523},"cordis-european-research-council-award-637844","Holomorphic Blocks in  Quantum Field Theory: New Constructions of Exact Results","UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA","€1,287,088","A central challenge in theoretical physics is to develop non-perturbative or exact methods to describe quantitatively the dynamics of strongly coupled quantum fields. This proposal aims to establish new exact methods for the study of  supersymmetric  quantum field theories  thereby  unveiling new integrable structures and fostering new  correspondences and dualities. We will develop a  new  cut-and-sew formalism to compute partition functions and  expectation values of observables  of supersymme",{"id":525,"funder":7,"programme":8,"title":526,"piName":10,"institution":527,"country":528,"year":13,"amount":529,"abstract":530},"cordis-european-research-council-award-639508","Bivariational Approximations in Quantum Mechanics and Applications to Quantum Chemistry","UNIVERSITETET I OSLO","NO","€1,499,572","The standard variational principles (VPs) are cornerstones of quantum mechanics, and one can hardly overestimate their usefulness as tools for generating approximations to the time-independent andtime-dependent Schröodinger equations. The aim of the proposal is to study and apply a generalization of these, the bivariational principles (BIVPs), which arise naturally when one does not assume a priori that the system Hamiltonian is Hermitian.  This  unconventional approach may have transformative i",{"id":532,"funder":7,"programme":8,"title":533,"piName":10,"institution":527,"country":528,"year":13,"amount":534,"abstract":535},"cordis-european-research-council-award-639272","The role of 5HT3a inhibitory interneurons in sensory processing","€1,350,000","How do cortical circuits process sensory stimuli that leads to perception? Sensory input is encoded by complex interactions between principal excitatory neurons and a diverse population of inhibitory cells. Distinct inhibitory neurons control different subcellular domains of target principal neurons, suggesting specific roles of different cells during sensory processing. However, the individual contribution of these inhibitory subtypes to sensory processing remains poorly understood. This is mai",{"id":537,"funder":7,"programme":8,"title":538,"piName":10,"institution":527,"country":528,"year":13,"amount":539,"abstract":540},"cordis-european-research-council-award-639377","Effects of Medication Use in Pregnancy on Infant Neurodevelopment","€1,499,439","Currently, thousands of pregnant women in the EU and worldwide are being increasingly prescribed medications for which we do not have sufficient information on fetal safety. I hypothesize that our current understanding of safety pharmacology is oversimplified and that medication prescribed during pregnancy may play an unrecognized role in the development of neurodevelopmental disorders.In this research proposal we have the unique opportunity to use a large population-based birth cohort including",{"id":542,"funder":7,"programme":8,"title":543,"piName":10,"institution":527,"country":528,"year":13,"amount":544,"abstract":545},"cordis-european-research-council-award-637686","Resonant Nuclear Gamma Decay and the Heavy-Element Nucleosynthesis","€1,443,472","THE GRAND CHALLENGE: The “Holy Grail” of nuclear astrophysics is to understand the astrophysical processes responsible for the formation of the elements. A particularly challenging part is the description of the heavy-element nucleosynthesis. The only way to build the majority of these heavy nuclides is via neutron-capture processes. Unaccounted-for nuclear structure effects may drastically change these rates. MAIN HYPOTHESIS: Nuclear low-energy gamma-decay resonances at high excitation energies",{"id":547,"funder":7,"programme":8,"title":548,"piName":10,"institution":527,"country":528,"year":13,"amount":549,"abstract":550},"cordis-european-research-council-award-637760","Enacting the Good Economy: Biocapitalization and the little tools of valuation","€1,495,079","What shall we live off in the future? Where will our food come from, and what will form the basis for our economies? A so-called “blue revolution”, where fish become farmed rather than caught, is increasingly presented as an answer to the above questions. This transformation of the economy exemplifies ongoing efforts to produce new forms of capital out of the ordering and reordering of life. These processes are intimately related to the expanding life sciences, the bioeconomy and what is sometim",{"id":552,"funder":7,"programme":8,"title":553,"piName":10,"institution":554,"country":555,"year":13,"amount":556,"abstract":557},"cordis-european-research-council-award-637674","Frontier research in arterial fibre remodelling for vascular disease diagnosis and tissue engineering","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","IE","€1,521,875","Each year cardiovascular diseases such as atherosclerosis and aneurysms cause 48% of all deaths in Europe. Arteries may be regarded as fibre-reinforced materials, with the stiffer collagen fibres present in the arterial wall bearing most of the load during pressurisation. Degenerative vascular diseases such as atherosclerosis and aneurysms alter the macroscopic mechanical properties of arterial tissue and therefore change the arterial wall composition and the quality and orientation of the under",{"id":559,"funder":7,"programme":8,"title":560,"piName":10,"institution":554,"country":555,"year":13,"amount":10,"abstract":561},"cordis-european-research-council-award-638289","The Neural Determinants of Perceptual Decision Making in the Human Brain","How do we make reliable decisions given sensory information that is often weak or ambiguous? Current theories center on a brain mechanism whereby sensory evidence is integrated over time into a “decision variable” which triggers the appropriate action upon reaching a criterion. Neural signals fitting this role have been identified in monkey electrophysiology but efforts to study the neural dynamics underpinning human decision making have been hampered by technical challenges associated with non-",{"id":563,"funder":7,"programme":8,"title":564,"piName":10,"institution":554,"country":555,"year":13,"amount":565,"abstract":566},"cordis-european-research-council-award-639760","Plasmonic Enhancement and Directionality of Emission for Advanced Luminescent Solar Devices","€1,447,410","Applying photovoltaic (PV) panels to buildings is an important application for wider PV deployment and to achieving our 20% Renewable Energy EU targets by 2020.  PEDAL will develop a disruptive PV technology where record increases in efficiency are achieved and costs dramatically reduced; (1) Diffuse solar radiation will be captured to produce higher efficiencies with concentration ratios over 3 in plasmonically enhanced luminescent solar concentrators (PLSC).  Current LSC efficiency achieved is",{"id":568,"funder":7,"programme":8,"title":569,"piName":10,"institution":570,"country":555,"year":13,"amount":571,"abstract":572},"cordis-european-research-council-award-639192","Alternative life histories: linking genes to phenotypes to demography","UNIVERSITY COLLEGE CORK -  NATIONAL UNIVERSITY OF IRELAND, CORK","€1,499,202","Understanding how and why individuals develop strikingly different life histories is a major goal in evolutionary biology. It is also a prerequisite for conserving important biodiversity within species and predicting the impacts of environmental change on populations. The aim of my study is to examine a key threshold phenotypic trait (alternative migratory tactics) in a series of large scale laboratory and field experiments, integrating several previously independent perspectives from evolutiona",{"id":574,"funder":7,"programme":8,"title":575,"piName":10,"institution":61,"country":62,"year":13,"amount":576,"abstract":577},"cordis-european-research-council-award-638760","Theory of statistical topological insulators","€1,355,103","Topological insulators (TI) are a novel class of materials with insulating bulk and conducting surface. The conduction of the surface is protected by the topological properties of the bulk, as long as a fundamental symmetry is present (for instance time-reversal symmetry). My goal is to investigate to what limits does the protection hold in cases where the protecting symmetry is broken, and only present in statistical sense, after averaging over the disordered ensemble. In a pilot study I showed",{"id":579,"funder":7,"programme":8,"title":580,"piName":10,"institution":61,"country":62,"year":13,"amount":581,"abstract":582},"cordis-european-research-council-award-639749","Lens Antenna Arrays  for Coherent THz Cameras","€1,497,500","The THz region was limited to applications in radio astronomy and space science. In recent years, THz systems have expanded into many more areas of science, defence, security, and non-destructive industrial applications. Microwave based THz cameras have demonstrated the highest sensitivity at large distances. However, their current state of the art is comparable to the first analog photographic cameras characterized by long exposition times. Two fundamental problems have to be addressed to chang",{"id":584,"funder":7,"programme":8,"title":585,"piName":10,"institution":586,"country":80,"year":13,"amount":10,"abstract":587},"cordis-european-research-council-award-639729","Strategic Predictions for Quantum Field Theories","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","Ambitious Questions:*  How does the relatively calm macroscopic universe survive and emerge from the violent quantum fluctuations of its underlying microphysics? *  How do classical notions of space and time emerge from fundamental principles, and what governs their evolution? These questions are difficult to answer---perhaps impossible given current ideas and frameworks---but I believe a strategic path forward is to thoroughly understand the quantum predictions of our Yang-Mills and Gravity the",{"id":589,"funder":7,"programme":8,"title":590,"piName":10,"institution":586,"country":80,"year":13,"amount":51,"abstract":591},"cordis-european-research-council-award-639039","Probing quantum fluctuations of single electronic channels in model interacting systems","The fluctuation-dissipation theorem is a prominent milestone in Physics: It links the dissipative response of a physical system to its fluctuations, and provides a microscopic understanding of macroscopic irreversibility. Recent theoretical advances that have generalized the original fluctuation-dissipation theorem to non-linear quantum systems even far from equilibrium, ask for an experimental test, which is the aim of the project. We will measure the current fluctuations and dissipative respon",{"id":593,"funder":7,"programme":8,"title":594,"piName":10,"institution":595,"country":265,"year":13,"amount":10,"abstract":596},"cordis-european-research-council-award-639534","Discovery of breast cancer aggressiveness markers using topo-proteomics mapping","TEL AVIV UNIVERSITY","In the proposed research we will explore the functional proteomic diversity of histologically-defined regions within human breast tumors, aiming to identify novel protein biomarkers of tumor aggressiveness. Once identified, these proteins will serve as potent diagnostic markers and therapeutic targets. Towards this aim we will perform genome-scale proteomic profiling on tumor regions displaying diverse histopathology. This will be followed by functional investigation of these cancer cell sub-pop",{"id":598,"funder":7,"programme":8,"title":599,"piName":10,"institution":600,"country":62,"year":13,"amount":51,"abstract":601},"cordis-european-research-council-award-637587","From haplotype to phenotype: a systems integration of allelic variation, chromatin state and 3D genome data","STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS","High-throughput sequencing methods are breaching the barrier of $1000 per genome. This means that it will become feasible to sequence the genomes of many individual and create a deep catalog of the bulk of human genetic variation. A great task will lie in assigning function to all this genetic variation. Genome wide association studies have already shown that 40% of all loci significantly associated with disease are found in intergenic, supposedly regulatory regions. One of the current challenge",{"id":603,"funder":7,"programme":8,"title":604,"piName":10,"institution":605,"country":555,"year":13,"amount":606,"abstract":607},"cordis-european-research-council-award-637780","Frontier Research on the Dielectric Properties of Biological Tissue","UNIVERSITY OF GALWAY","€1,499,329","The dielectric properties of biological tissues are of fundamental importance to the understanding of the interaction of electromagnetic fields with the human body. These properties are used to determine the safety of electronic devices, and in the design, development and refinement of electromagnetic medical imaging and therapeutic devices. Many historical studies have aimed to establish the dielectric properties of a broad range of tissues. A growing number of recent studies have sought to mor",{"id":609,"funder":7,"programme":8,"title":610,"piName":10,"institution":595,"country":265,"year":13,"amount":10,"abstract":611},"cordis-european-research-council-award-637069","Uncovering the Role of Cancer Associated Fibroblasts in Facilitating Breast Cancer Metastasis","Mortality from breast cancer is almost exclusively a result of tumor metastasis. Since advanced metastatic cancers are usually fatal, understanding the biology of tumor metastasis is the most significant challenge in cancer research today. It has become clear that the microenvironment of tumors is crucial in supporting tumor growth. Nevertheless, the role of the metastatic microenvironment in facilitating metastatic colonization is largely unknown. We recently uncovered a novel role for Cancer-A",{"id":613,"funder":7,"programme":8,"title":614,"piName":10,"institution":615,"country":80,"year":13,"amount":51,"abstract":616},"cordis-european-research-council-award-640643","Study on Environmental and GenomeWide predictors of early structural brain Alterations in Young students","UNIVERSITE DE BORDEAUX","Mounting evidence suggests that early life factors have an important impact on the occurrence of late-life neurological diseases. From a public health perspective this is of particular relevance for dementia, the prevalence of which is increasing drastically, with no available preventive treatment, and epidemiological data suggesting that pathological processes may begin many years before clinical diagnosis. MRI-defined structural brain phenotypes are powerful intermediate markers for dementia, ",{"id":618,"funder":7,"programme":8,"title":619,"piName":10,"institution":620,"country":27,"year":13,"amount":621,"abstract":622},"cordis-european-research-council-award-638718","Custom-made biosensors – Accelerating the transition to a bio-based economy","FORSCHUNGSZENTRUM JULICH GMBH","€1,482,220","How will we meet the globally growing demand for pharmaceutically active compounds, nutrients and fine chemicals when crude oil resources are dwindling? For decades, biotechnologists have been engineering microorganisms to produce valuable compounds from sugar and biomass. However, a lack of knowledge regarding the host cell metabolism as well as long and laborious development times render this approach challenging to this day.I want to establish a platform to engineer transcriptional biosensors",{"id":624,"funder":7,"programme":8,"title":625,"piName":10,"institution":369,"country":34,"year":13,"amount":51,"abstract":626},"cordis-european-research-council-award-639072","The Evolutionary and Developmental Origins of Inquiring Minds: Studies of Causal Reasoning; Curiosity and Executive Control","Human technology is vastly superior to that of other apes: human tools from telescopes to the Large Hadron Collider exploit causal relationships but also explore them. What change over the brief course of hominid evolution made for such a big difference? One theory implicates a single cognitive distinction: the ability to reinterpret the world in abstract terms. In contrast, in several studies, chimpanzees seemed to rely on surface appearances, as if for the apes there was no more to the situati",{"id":628,"funder":7,"programme":8,"title":629,"piName":10,"institution":630,"country":300,"year":13,"amount":10,"abstract":631},"cordis-european-research-council-award-637747","Rationality in Perception: Transformations of Mind and Cognition 1250-1550","HELSINGIN YLIOPISTO","The project RiP aims to provide a groundbreaking new interpretation of late medieval theories of mind and cognition by focusing on the influence higher cognitive (rational) powers exert on lower (sensory) ones in the neglected tradition of Augustinian philosophy of perception. Due to increasing difficulties in explaining the unity and objectivity of perceptual experience, late medieval authors came to question the dominant Aristotelian theory, with its passive account of perception and emphatic ",{"id":633,"funder":7,"programme":8,"title":634,"piName":10,"institution":635,"country":27,"year":13,"amount":636,"abstract":637},"cordis-european-research-council-award-637654","Micro-scale inhomogeneities in compressed systems and their impact onto the PROCESS- functioning-chain and the PRODUCT-characteristics","TECHNISCHE UNIVERSITAET BERGAKADEMIE FREIBERG","€1,943,750","Compressed fluid systems handled in high pressure processes feature diffusivities smaller than the kinematic viscosity. Therefore during mixing the lifetime of micro(µ)-scale(s) inhomogeneities exceeds that one of macro(m)-scale(s) inhomogeneities. Thus m-s homogeneous systems can still exhibit µ-s inhomogeneities. They affect the functioning-chain of processes, e.g. reactions and phase-transitions or –separations, which themselves also take place on a sub-macro-scale.Therefore it will be analyz",{"id":639,"funder":7,"programme":8,"title":640,"piName":10,"institution":641,"country":642,"year":13,"amount":643,"abstract":644},"cordis-european-research-council-award-639220","Dynamics of Supersymmetry in Curved Space","UPPSALA UNIVERSITET","SE","€1,145,879","Quantum field theory provides a theoretical framework to explain quantitatively natural phenomena as diverse as the fluctuations in the cosmic microwave background, superconductivity, and elementary particle interactions in colliders. Even if we use quantum field theories in different settings, their structure and dynamics are still largely mysterious. Weakly coupled systems can be studied perturbatively, however many natural phenomena are characterized by strong self-interactions (e.g. high T s",{"id":646,"funder":7,"programme":8,"title":647,"piName":10,"institution":648,"country":34,"year":13,"amount":649,"abstract":650},"cordis-european-research-council-award-637995","Probabilistic and Dynamical Study of Nonlinear Dispersive Equations","THE UNIVERSITY OF EDINBURGH","€1,007,811","Nonlinear dispersive partial differential equations (PDEs) appear ubiquitously as models describing wave phenomena in various branches of physics and engineering. Over the last few decades, multilinear harmonic analysis has played a crucial role in the development of the theoretical understanding of the subject. Furthermore, in recent years, a non-deterministic point of view has been incorporated into the study of nonlinear dispersive PDEs, enabling us to study typical behaviour of solutions in ",{"id":652,"funder":7,"programme":8,"title":653,"piName":10,"institution":654,"country":62,"year":13,"amount":655,"abstract":656},"cordis-european-research-council-award-637640","Defining how environmental factors influence downstream effects of immune-mediated disease risk-SNPs","ACADEMISCH ZIEKENHUIS GRONINGEN","€1,496,690","In the last few years genome-wide association studies have revealed thousands of genetic variants associated to immune-mediated diseases, such as rheumatoid arthritis and Crohn's disease. Although it is evident that non-genetic factors can also trigger these diseases, presumably by interacting with the risk SNPs, we do not know what these factors are or how they affect risk-SNPs.I hypothesize that environmental factors that increase disease risk also mediate the downstream molecular effects of d",{"id":658,"funder":7,"programme":8,"title":659,"piName":10,"institution":660,"country":27,"year":13,"amount":51,"abstract":661},"cordis-european-research-council-award-638197","Origin and Protection of Unstable Repetitive DNA Elements During Sexual Reproduction","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","The objective of this proposal is to define the molecular basis behind the origin and protection of unstable repetitive DNA sequences during sexual reproduction. Eukaryotic genomes contain large amounts of repetitive elements that serve vital roles in cellular physiology. However, repetitive elements are intrinsically unstable, which is caused by a high likelihood for incorrect repair when DNA breaks form within repetitive elements. During sexual reproduction, numerous DNA breaks are actively in",{"id":663,"funder":7,"programme":8,"title":664,"piName":10,"institution":665,"country":27,"year":13,"amount":51,"abstract":666},"cordis-european-research-council-award-637692","Localizing 4000 Years of Cultural History. Texts and Scripts from Elephantine Island in Egypt","STIFTUNG PREUSSISCHER KULTURBESITZ","The aim of this project is to write a cultural history of 4000 years, localized on Elephantine Island in Egypt.Elephantine was a militarily and strategically very important island in the river Nile on the southern borderof Egypt. No other settlement in Egypt is so well attested over such a long period of time. Its inhabitantsform a multi-ethnic, multicultural and multi-religious community that left us vast amounts of written sourcesdetailing their everyday lives from the Old Kingdom to beyond th",{"id":668,"funder":7,"programme":8,"title":669,"piName":10,"institution":670,"country":12,"year":13,"amount":671,"abstract":672},"cordis-european-research-council-award-637533","Bilingualism in Florentine and Tuscan Works (ca. 1260 - ca. 1416)","UNIVERSITA CA' FOSCARI  VENEZIA","€1,480,625","This project will undertake the first systematic investigation of the various literary documents that circulated simultaneously in more than one language in Tuscany, and especially Florence, between the mid-13th Century and the beginning of 15th Century. During that period, Florence was both a prominent literary centre in the vernacular, and home to a renewal of classical Latin eloquence. While both fields are well studied, their interaction remains largely unexplored. This research, at the conv",{"id":674,"funder":7,"programme":8,"title":675,"piName":10,"institution":660,"country":27,"year":13,"amount":51,"abstract":676},"cordis-european-research-council-award-640422","Greenhouse Gas Mitigation through Advanced Nitrogen Removal Technology","Human activities have severe impacts on the biological carbon and nitrogen cycles. The most important consequences of these are global warming and water pollution. Wastewater treatment technology, in particular nitrogen removal systems, improved considerably in the last decade. The application of anaerobic ammonium oxidizing (anammox) bacteria in oxygen-limited granules has the potential to turn wastewater treatment plants into energy-efficient systems with minimal greenhouse gas emissions of ca",{"id":678,"funder":7,"programme":8,"title":679,"piName":10,"institution":680,"country":20,"year":13,"amount":681,"abstract":682},"cordis-european-research-council-award-639068","Challenging the Standard Model using an extended Physics program in LHCb","UNIVERSIDAD DE SANTIAGO DE COMPOSTELA","€1,499,855","We know that the Standard Model (SM) of Particle Physics is not the ultimate theory of Nature. It misses a quantum description of gravity, it does not offer any explanation to the composition of Dark Matter, and the matter-antimatter unbalance of the Universe is predicted to be significantly smaller than what we actually see. Those are fundamental questions that still need an answer. Alternative models to SM exist, based on ideas such as SuperSymmetry or extra dimensions, and are currently being",{"id":684,"funder":7,"programme":8,"title":685,"piName":10,"institution":686,"country":642,"year":13,"amount":51,"abstract":687},"cordis-european-research-council-award-638546","Detailed Characterization of Spray Systems using Novel Laser Imaging Techniques","LUNDS UNIVERSITET","The multiple scattering of light is a complex phenomenon, commonly encountered but rarely desired. In imaging it induces strong blurring on the recorded photographs, limiting the range of applicability and accuracy of modern optical instruments. A typical example concerns the laser diagnostics of spray systems. The PI has revealed in 2008 a technique based on structured illumination with the important capability to remove the contributions from multiple light scattering, allowing the unique poss",{"id":689,"funder":7,"programme":8,"title":690,"piName":10,"institution":691,"country":34,"year":13,"amount":692,"abstract":693},"cordis-european-research-council-award-639022","New frontiers in numerical general relativity","QUEEN MARY UNIVERSITY OF LONDON","€1,284,525","In recent years general relativity (GR) has become an increasingly important new tool in areas of physics beyond its traditional playground in astrophysics. The main motivation for this comes from the AdS\u002FCFT correspondence which conjectures an equivalence between gravity in anti-de Sitter (AdS) spaces and certain conformal field theories (CFT’s). Via this correspondence, GR now plays a key role in improving our understanding of non-gravitational physics at strong coupling.The AdS\u002FCFT correspond",{"id":695,"funder":7,"programme":8,"title":696,"piName":10,"institution":595,"country":265,"year":13,"amount":697,"abstract":698},"cordis-european-research-council-award-637386","Symplectic Measurements and Hamiltonian Dynamics","€1,221,921","Symplectic geometry combines a broad spectrum of interrelated disciplines lying in the mainstream of modern mathematics. The past two decades have given rise to several exciting developments in this field, which introduced new mathematical tools and opened challenging new questions. Nowadays symplectic geometry reaches out to an amazingly wide range of areas, such as differential and algebraic geometry, complex analysis, dynamical systems, as well as quantum mechanics, and string theory. Moreove",{"id":700,"funder":7,"programme":8,"title":701,"piName":10,"institution":702,"country":62,"year":13,"amount":703,"abstract":704},"cordis-european-research-council-award-638647","Aiding Social Protection: the political economy of externally financing social policy in developing countries","ERASMUS UNIVERSITEIT ROTTERDAM","€1,459,529","This research proposal explores the political economy of international development assistance (aid) directed towards social expenditures, examined through the lens of a particular financial quandary that has been ignored in the literature despite having important economic and political repercussions. The quandary is that aid cannot be directly spent on expenditures denominated in domestic currency. Instead, aid needs to be first converted into domestic currency whereas the foreign exchange provi",{"id":706,"funder":7,"programme":8,"title":707,"piName":10,"institution":311,"country":286,"year":13,"amount":10,"abstract":708},"cordis-european-research-council-award-636069","Organic Mixed Ion and Electron Conductors for High-Energy Batteries","Energy storage is undeniably amongst the greatest societal challenges. Batteries will be key enablers but require major progress. Battery materials that promise a step-change in energy density compared with current Li-ion batteries rely on fundamentally different reactions to store charge, e.g. Si alloying or O2 reduction instead of intercalation. They have in common high volume changes on cycling and poor conductivity. For the active component of a battery electrode to function it must be simul",{"id":710,"funder":7,"programme":8,"title":711,"piName":10,"institution":712,"country":62,"year":13,"amount":713,"abstract":714},"cordis-european-research-council-award-638514","Profiling and targeting news readers – implications for the democratic role of the digital media, user rights and public information policy","UNIVERSITEIT VAN AMSTERDAM","€1,479,515","In the digital media environment, user attention is scarce and competition for ‘eyeballs’ is fierce. Profiling and targeting readers with customised news and advertisements that match their individual interests is widely seen as a solution. The personalization of news media content enables new financing strategies and means to capture the audience’s attention. But personalisation is also part of a more fundamental paradigm shift in the media’s role from public interest intermediary to personal i",{"id":716,"funder":7,"programme":8,"title":717,"piName":10,"institution":718,"country":27,"year":13,"amount":719,"abstract":720},"cordis-european-research-council-award-638425","Enhanced Qualitative and Multi-Method Research in Political Science","UNIVERSITAT ZU KOLN","€1,125,575","Over the last 20 years, qualitative methods in political science have developed rapidly on three dimen-sions. First, set theory was formulated as an alternative to what is called the quantitative worldview. Second, process tracing for the analysis of mechanisms evolved as a complement to the estimation of marginal effects. Process tracing has also been tied to Bayesianism as opposed to frequentism. Third, process tracing became an element of multi-method research (MMR), integrating it with frequ",{"id":722,"funder":7,"programme":8,"title":723,"piName":10,"institution":724,"country":265,"year":13,"amount":725,"abstract":726},"cordis-european-research-council-award-637456","Elucidation of the evolution of post-transcriptional regulation by characterizing the cnidarian microRNA pathway","THE HEBREW UNIVERSITY OF JERUSALEM","€1,499,587","Over the past decade small RNAs such as microRNAs (miRNAs) and small interfering RNAs (siRNAs) have been shown to carry pivotal roles in post-transcriptional regulation and genome protection and to play an important part in various physiological processes in animals. miRNAs can be found in a very wide range of animals yet their functions were studied almost exclusively in members of the Bilateria such as insects, nematodes and vertebrates. Hence studying their function in representatives of non-",{"id":728,"funder":7,"programme":8,"title":729,"piName":10,"institution":730,"country":34,"year":13,"amount":731,"abstract":732},"cordis-european-research-council-award-640537","Real-TIME probing of Ultrafast Phenomena","HERIOT-WATT UNIVERSITY","€1,999,407","The perception of the world surrounding us depends on how we illuminate and capture it. For example, our direct observation of high-speed phenomena is limited by the speed of the human visual system. A well known method to visualize fast events is to capture them at very high frame rates with high-speed cameras, and then play the movie in slow-motion, enabling us to understand what happens at short timescales. The ultimate goal of this project is to develop the fastest camera on earth, able not ",{"id":734,"funder":7,"programme":8,"title":735,"piName":10,"institution":648,"country":34,"year":13,"amount":736,"abstract":737},"cordis-european-research-council-award-637709","Illuminating the 'Grey Zone': Addressing Complex Complicity in Human Rights Violations","€1,349,481","The grey zone of bystanders, collaborators and beneficiaries of violence escapes the scope of main Transitional Justice (TJ) institutions and poses tough questions for scholars and architects of post-conflict societies. This interdisciplinary project shifts the focus of academic and political debates by pursuing three objectives: conceptually, it departs from the dominant victim-perpetrator paradigm and theorises the many faces in the grey zone by analysing the interplay between structure and ag",{"id":739,"funder":7,"programme":8,"title":740,"piName":10,"institution":741,"country":12,"year":13,"amount":742,"abstract":743},"cordis-european-research-council-award-638059","High-frequency printed and direct-written Organic-hybrid Integrated Circuits","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","€1,608,125","The HEROIC project aims at filling the gap between the currently low operation frequencies of printed, organic flexible electronics and the high-frequency regime, by demonstrating polymer-based field-effect transistors with maximum operation frequencies of 1 GHz and complementary integrated logic circuits switching in the 10-100 MHz range, fabricated by means of printing and direct-writing scalable processes in order to retain low temperature manufacturability of cost-effective large area electr",{"id":745,"funder":7,"programme":8,"title":746,"piName":10,"institution":26,"country":27,"year":13,"amount":747,"abstract":748},"cordis-european-research-council-award-637752","Biochemically modified messenger RNA encoding nucleases for in vivo gene correction of severe inherited lung diseases","€1,497,125","Surfactant Protein B (SP-B) deficiency and Cystic Fibrosis (CF) are severe, fatal inherited diseases affecting the lungs of ten thousands of people, for which there is currently no available cure. Although gene therapy is a promising therapeutic approach, various technical problems, including numerous physical and immune-mediated barriers, have prevented successful application to date. My recent studies were the first to demonstrate the life-saving efficacy of repeated pulmonary delivery of chem",{"id":750,"funder":7,"programme":8,"title":751,"piName":10,"institution":648,"country":34,"year":13,"amount":10,"abstract":752},"cordis-european-research-council-award-637618","The Quantum Geometric Langlands Topological Field Theory","We will use modern techniques in derived algebraic geometry, topological field theory and quantum groups to construct quantizations of character varieties, moduli spaces parameterizing G-bundles with flat connection on a surface.  We will leverage our construction to shine new light on the geometric representation theory of quantum groups and double affine Hecke algebras (DAHA's), and to produce new invariants of knots and 3-manifolds.Our previous research has uncovered strong evidence for the e",{"id":754,"funder":7,"programme":8,"title":755,"piName":10,"institution":756,"country":34,"year":13,"amount":10,"abstract":757},"cordis-european-research-council-award-637313","Entangled pincer ligand architectures and their application in the transition-metal-mediated activation of alkanes","UNIVERSITY OF WARWICK","The selective transformation of alkanes is an area of contemporary importance with wide-ranging implications for organic synthesis and the effective use of petroleum resources. While homogeneous transition metal catalysis is a potentially powerful means for achieving this objective, the fundamental organometallic chemistry of alkane activation reactions has proven to be exceedingly difficult to investigate due to the weakly interacting nature of alkanes. To address this knowledge gap and provide",{"id":759,"funder":7,"programme":8,"title":760,"piName":10,"institution":660,"country":27,"year":13,"amount":761,"abstract":762},"cordis-european-research-council-award-638810","Unraveling the history of adaptation in an island model: Cape Verde Arabidopsis","€1,609,375","Islands have played a pivotal role in evolutionary theory since Darwin and Wallace. Due to their isolation, they represent natural laboratories, providing uncomplicated microcosms where fundamental principles of the evolutionary process can be revealed. One area where island systems can provide a crucial advance is in evolutionary genetics. Here, a primary goal is to reconstruct the mechanisms, mode and tempo of the evolutionary process by identifying specific adaptive functional variants and st",{"id":764,"funder":7,"programme":8,"title":765,"piName":10,"institution":766,"country":12,"year":13,"amount":767,"abstract":768},"cordis-european-research-council-award-640594","Cortical Representation of Abstract Semantic Knowledge","UNIVERSITA DEGLI STUDI DI TRENTO","€1,472,502","The study of semantic memory considers a broad range of knowledge extending from basic elemental concepts that allow us to recognise and understand objects like ‘an apple’, to elaborated semantic information such as knowing when it is appropriate to use a Wilcoxon Rank-Sum test. Such elaborated semantic knowledge is fundamental to our daily lives yet our understanding of the neural substrates is minimal. The objective of CRASK is to advance rapidly beyond the state-of-the-art to address this iss",{"id":770,"funder":7,"programme":8,"title":771,"piName":10,"institution":772,"country":62,"year":13,"amount":370,"abstract":773},"cordis-european-research-council-award-638193","Molecular Subtype Specific Stem Cell Dynamics in Developing and Established Colorectal Cancers","ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM","Annually 1.2 million new cases of colorectal cancer (CRC) are seen worldwide and over 50% of patients die of the disease making it a leading cause of cancer-related mortality. A crucial contributing factor to these disappointing figures is that CRC is a heterogeneous disease and tumours differ extensively in the clinical presentation and response to therapy. Recent unsupervised classification studies highlight that only a proportion of this heterogeneity can be explained by the variation in comm",{"id":775,"funder":7,"programme":8,"title":776,"piName":10,"institution":777,"country":293,"year":13,"amount":778,"abstract":779},"cordis-european-research-council-award-638154","Conflict and Cooperation in the EU Heterarchical Legal System","KATHOLIEKE UNIVERSITEIT LEUVEN","€1,475,150","Supranational legal regimes are increasingly enforced by multi-level, non-hierarchical court systems, in which judges at the upper, supranational echelon do not have the power to reverse domestic court decisions. Yet the incentives and dynamics that shape the complex patterns of conflict and cooperation observed in the most important of all such court structures, the EU legal system, are still poorly understood. To what extent are domestic courts able to negotiate the terms of their cooperation ",{"id":781,"funder":7,"programme":8,"title":782,"piName":10,"institution":783,"country":12,"year":13,"amount":784,"abstract":785},"cordis-european-research-council-award-639286","Plant foods in Palaeolithic and Mesolithic societies of SE Europe and Italy","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","€1,499,856","The role of plant foods among prehistoric hunter-gatherer societies remains one of the major issues of World Prehistory. Recovering evidence for the use of plants in ancient forager diets presents many difficulties due to the low rate of survival of organic remains. More recently, developments of various methodological tools and analytical procedures for studying the importance of plant foods in the past have started to provide means for reaching realistic estimates about the role of plant foods",{"id":787,"funder":7,"programme":8,"title":788,"piName":10,"institution":789,"country":27,"year":13,"amount":10,"abstract":790},"cordis-european-research-council-award-640554","Policy Learning of Motor Skills for Humanoid Robots","TECHNISCHE UNIVERSITAT DARMSTADT","The goal of SKILLS4ROBOTS is to develop a autonomous skill learning system that enables humanoid robots to acquire and improve a rich set of motor skills. This robot skill learning system will allow scaling of motor abilities up to fully anthropomorphic robots while overcoming the current limitations of skill learning systems to only few degrees of freedom. To achieve this goal, it will decompose complex motor skills into simpler elemental movements – called movement primitives – that serve as b",{"id":792,"funder":7,"programme":8,"title":793,"piName":10,"institution":794,"country":34,"year":13,"amount":10,"abstract":795},"cordis-european-research-council-award-639564","Cultural Heritage and Economic Development in International and European Law","UNIVERSITY OF LANCASTER","Can states promote economic development without infringing upon their cultural heritage? Although economic globalization and international economic governance have spurred a more intense dialogue and interaction among nations - potentially promoting cultural diversity and providing the funds to recover and preserve cultural heritage - these phenomena can also jeopardize the cultural wealth of nations. Trade in cultural products can lead to cultural homogenization and even to cultural hegemony. I",{"id":797,"funder":7,"programme":8,"title":798,"piName":10,"institution":660,"country":27,"year":13,"amount":51,"abstract":799},"cordis-european-research-council-award-640254","Metabolic and Genetic Regulation of Ageing","Ageing is a complex physiological process that affects almost all species, including humans. Despite its importance for all of us, the biology of ageing is insufficiently understood. To uncover the molecular underpinnings of ageing, I propose an interdisciplinary research program that will identify and investigate metabolic and genetic regulators of ageing.Progressive loss of cellular homeostasis causes ageing and an age-associated decline in protein quality control has been implicated in numero",{"id":801,"funder":7,"programme":8,"title":802,"piName":10,"institution":712,"country":62,"year":13,"amount":803,"abstract":804},"cordis-european-research-council-award-638946","Corporate Network Governance: Power, Ownership and Control in Contemporary Global Capitalism","€1,497,764","The character of global business networks has long fascinated but continues to divide scholars of global markets and governance. A well-established perspective looks at the changes in global networks and sees an emerging cohesive transnational capitalist class. However, a rival line of inquiry sees the rise of competing corporate elites.  Scholars also disagree on the origins of emergent patterns of corporate networks. Do they reflect institutional preferences of corporate and political elites? ",{"id":806,"funder":7,"programme":8,"title":807,"piName":10,"institution":808,"country":12,"year":13,"amount":809,"abstract":810},"cordis-european-research-council-award-639284","INTerEthnic Relationships in contemporAry CommuniTies: How does ethnoracial diversity affect in- and out-group trust, solidarity, and cooperation","UNIVERSITA COMMERCIALE LUIGI BOCCONI","€969,100","The increasingly multiethnic nature of modern societies has spurred academic interest in the consequences of diversity. Recent scholarship has linked ethnoracial diversity to undesirable collective outcomes, e.g., low levels of trust, civic engagement, and social capital. These findings have important policy implications, in part because they resonate with public anxieties about immigration, residential integration, and the role of the welfare state. The proposed research will investigate the mi",{"id":812,"funder":7,"programme":8,"title":813,"piName":10,"institution":595,"country":265,"year":13,"amount":814,"abstract":815},"cordis-european-research-council-award-638049","Synthesis Technologies for Reactive Systems Software Engineers","€1,477,000","The design and development of open reactive systems, which compute by reacting to ongoing stimuli from their environment, and include, for example, mobile applications running on smart phone devices, web-based applications, industrial robotic systems, embedded software running on chips inside cars and aircraft, etc., is a complex and challenging task. Despite advancement from low-level assembly languages to higher-level languages with powerful abstraction mechanisms, and the use of automated tes",{"id":817,"funder":7,"programme":8,"title":818,"piName":10,"institution":819,"country":293,"year":13,"amount":820,"abstract":821},"cordis-european-research-council-award-639008","Mind-Bending Grammars: The dynamics of correlated multiple grammatical changes in Early Modern English writers","UNIVERSITEIT ANTWERPEN","€1,208,025","Mind-Bending Grammars examines change in mental grammars of 17th century individuals across their lifespan as attested in their writings. The project treats grammar as a self-organizing network of form-meaning schemas continuously fine-tuning itself, where activating one schema may prime formally or functionally associated ones. In analyzing multiple grammar changes in healthy adults it aspires to make a breakthrough in the cognitive modelling of grammar, and is expected to bear on views of cogn",{"id":823,"funder":7,"programme":8,"title":824,"piName":10,"institution":825,"country":27,"year":13,"amount":51,"abstract":826},"cordis-european-research-council-award-636746","Human Cooperation to Protect the Global Commons","UNIVERSITAET KASSEL","The objectives of this research are to reveal the nature of large-scale human cooperation and to develop strategies for the protection of our global environment. Human activities are now the major driver of change in the biosphere, including the climate, the water cycle, and the distribution of species and biodiversity – with adverse effects that range from the local to the global scale. Since there is no world government that can enforce the protection of the global commons we have to rely on v",{"id":828,"funder":7,"programme":8,"title":829,"piName":10,"institution":155,"country":150,"year":13,"amount":830,"abstract":831},"cordis-european-research-council-award-638902","Utilizing evolutionary interactions to limit multidrug resistance","€1,492,453","Drug resistance is limiting our ability to treat most infectious diseases and forms of cancer. Indeed this relentless evolution is the major driver of treatment failure for diseases that are responsible for over half of the global disease related mortality. Yet, the underlying principles that guide this evolutionary response are poorly understood, in particular with regards to understanding the impact of multidrug treatment.  LimitMDR will characterize evolutionary trajectories leading to multid",{"id":833,"funder":7,"programme":8,"title":834,"piName":10,"institution":393,"country":27,"year":13,"amount":10,"abstract":835},"cordis-european-research-council-award-637645","Wayfinding Through Orientation","Wayfinding is a task that we manage every day while going to work or on vacation. Although wayfinding research has gone through tremendous development, it suffers from fundamental shortcomings: State-of-the art wayfinding research still adheres to the principles of turn-by-turn navigation.This proposal suggests a new wayfinding paradigm “Wayfinding Through Orientation” that supports the acquisition of spatial knowledge and cognitive mapping for advancing the user’s orientation. Users learn the s",{"id":837,"funder":7,"programme":8,"title":838,"piName":10,"institution":712,"country":62,"year":13,"amount":839,"abstract":840},"cordis-european-research-council-award-640159","Moonshine and String Theory","€1,256,624","The purpose of the proposed research is to forward the understanding of the umbral moonshine discovered recently by myself. I plan to study it in the context of string theory. Moreover, I aim to use this new discovery to gain a deeper understanding of certain fundamental aspects of the theory. The term moonshine refers to the astonishing and puzzling relation between functions with special symmetries (modular properties) and finite groups. The novel type of moonshine involves the so-called mock ",{"id":842,"funder":7,"programme":8,"title":843,"piName":10,"institution":844,"country":34,"year":13,"amount":130,"abstract":845},"cordis-european-research-council-award-640488","Doing Intimacy:  A Multi-sited Ethnography of Modern Chinese Family Life","SCHOOL OF ORIENTAL AND AFRICAN STUDIES ROYAL CHARTER","Families in Western countries have received a great deal of attention from social scientists but there is less information on family life in other regions of the world. Given its growing rapidly in global influence, China represents a crucial region for sociological advancement and understanding. There have been profound changes in the Chinese family over the last century as a result of industrialization, urbanization, the influence of the West and the political interventions carried out by the ",{"id":847,"funder":7,"programme":8,"title":848,"piName":10,"institution":849,"country":62,"year":13,"amount":51,"abstract":850},"cordis-european-research-council-award-635356","Releasing Prisoners Of The Paradigm: Understanding How Cooperation Varies Across Contexts In The Lab And Field","STICHTING VU","Cooperation is essential for mitigating conflict between individual and collective interests in relationships and groups, such as providing public goods and conserving resources. Most research testing psychological and economic theory of cooperation has applied a highly specific lab method (e.g., the prisoner’s dilemma) that unnecessarily constrains the applicability of research findings. The discrepancies between cooperation observed in the lab and field can be due to variation in interdependen",{"id":852,"funder":7,"programme":8,"title":853,"piName":10,"institution":660,"country":27,"year":13,"amount":854,"abstract":855},"cordis-european-research-council-award-633818","Atomic-Scale Dynamics of Quantum Materials","€1,988,100","Quantum materials exhibit strong electron-electron interaction, which gives rise to such remarkable phenomena as high temperature superconductivity and colossal magnetoresistance. These materials mark one of the frontiers of modern condensed matter physics: a new class of solids where many-body physics dominates. By understanding quantum materials a new generation of devices may become available, greatly boosting our ability to handle information or harvest energy. A key difficulty is that corre",{"id":857,"funder":7,"programme":8,"title":858,"piName":10,"institution":859,"country":34,"year":13,"amount":860,"abstract":861},"cordis-european-research-council-award-638333","Evolutionary origins of complex ecological adaptations","THE UNIVERSITY OF SHEFFIELD","€1,498,275","During evolution, organisms adapt to diverse environmental conditions by evolving new morphological and\u002For biochemical traits, some of which are of impressive complexity. This is for example the case of eyes, wings or complex biochemical pathways, which all involve multiple components. The evolution of such complex traits has always intrigued evolutionary biologists, including Charles Darwin, and is still only partially understood. How can natural selection on random mutations lead over time to ",{"id":863,"funder":7,"programme":8,"title":864,"piName":10,"institution":660,"country":27,"year":13,"amount":51,"abstract":865},"cordis-european-research-council-award-633428","Reverse engineering sensory perception and decision making: bridging physiology, anatomy and behavior","Understanding how the brain is able to transform sensory input into decisions is one of the major challenges of systems neuroscience. While recording\u002Fimaging during sensory-motor tasks identified neural substrates of sensation and action in various cortical areas, the crucial questions of 1) how these correlates are implemented within the underlying neural networks and 2) how their output triggers decisions, will only be answered when the individual functional measurements are integrated into a ",{"id":867,"funder":7,"programme":8,"title":868,"piName":10,"institution":869,"country":870,"year":13,"amount":51,"abstract":871},"cordis-european-research-council-award-639846","Novel Nanoengineered Optoelectronic Biointerfaces","KOC UNIVERSITY","TR","Interfacing with neural tissues is an important scientific goal to understand cellular processes and to combat nervous-system related diseases. Nanotechnology has a significant potential for the development of new neural interfaces. The atomic-level design and control of the nanostructures for neural interfacing can revolutionize the junction between neurons and nanomaterials. In this project, we propose a totally new approach for understanding fundamental requirements and from this knowledge de",{"id":873,"funder":7,"programme":8,"title":874,"piName":10,"institution":875,"country":286,"year":13,"amount":876,"abstract":877},"cordis-european-research-council-award-637462","Energy and emissions thresholds for providing decent living standards to all","INTERNATIONALES INSTITUT FUER ANGEWANDTE SYSTEMANALYSE","€869,722","There is confusion surrounding how poverty eradication will contribute to climate change. This is due to knowledge gaps related to the material basis of poverty, and the relationship between energy and human development.  Addressing this issue rigorously requires bridging gaps between global justice, economics, energy systems analysis, and industrial ecology, and applying this knowledge to projections of anthropogenic greenhouse gases. This project will develop a body of knowledge that quantifie",{"id":879,"funder":7,"programme":8,"title":880,"piName":10,"institution":595,"country":265,"year":13,"amount":881,"abstract":882},"cordis-european-research-council-award-639402","Mid Infra-Red near-field control by Adiabatic frequency Generation Enabling 20fs\u002F15nm resolution","€1,493,250","The goal of this proposal is to allow observing and controlling ultrafast phenomena in a spatio-temporal window of 20fs-15nm at mid-IR by merging the extreme temporal resolution of the recently developed single-cycle mid-IR pulses with the spatial resolution of near field scattering optical microscope (aSNOM). The mid-infrared wavelength regime is of particular importance to materials science, chemistry, biology and condensed matter physics, as it covers the fundamental vibrational absorption ba",{"id":884,"funder":7,"programme":8,"title":885,"piName":10,"institution":886,"country":27,"year":13,"amount":10,"abstract":887},"cordis-european-research-council-award-637920","Self-regenerating Functional Surfaces – Towards a Technology Platform for New Materials and Devices","ALBERT-LUDWIGS-UNIVERSITAET FREIBURG","Self-regenerating materials are intriguing. If critical properties of a failing material or device could be easily restored, this would significantly extend its life time. In this proposal, we describe our vision of a technology platform for the self-regeneration of surface properties. Functional surfaces fail due to damage or contamination. Instead of trying to make “better” functional materials, we here propose a fundamental change in the design of such materials. We want to make a material th",{"id":889,"funder":7,"programme":8,"title":890,"piName":10,"institution":891,"country":286,"year":13,"amount":184,"abstract":892},"cordis-european-research-council-award-640396","Optical imaging of ocular pathology in Alzheimer’s disease","MEDIZINISCHE UNIVERSITAET WIEN","Novel diagnostic techniques and disease models have the powerful potential to provide new insights into pathological and pathophysiological processes. Ocular manifestations of Alzheimer’s disease (AD) emerge as novel and attractive alternative to investigate disease progression in parallel to the brain. Using the eye as a window to the brain, we propose to develop multi-functional optical coherence tomography (OCT) as a noninvasive in-vivo technique for preclinical imaging of AD pathology. OCT i",{"id":894,"funder":7,"programme":8,"title":895,"piName":10,"institution":605,"country":555,"year":13,"amount":896,"abstract":897},"cordis-european-research-council-award-640580","Clarifying Optimal Sodium Intake Project","€1,499,431","Hypertension is a leading risk factor for cardiovascular disease (CVD) globally, accounting for 25-35% of the population-attributable fraction. Sodium (salt) intake is a key determinant of blood pressure, and reducing sodium intake has emerged as an important target for population-based interventions to prevent CVD. However, there is considerable uncertainty about the optimal level of sodium (salt) intake that is associated with lowest CVD risk, and whether optimal levels differ for different po",{"id":899,"funder":7,"programme":8,"title":900,"piName":10,"institution":901,"country":27,"year":13,"amount":10,"abstract":902},"cordis-european-research-council-award-638178","Non-coding RNA in Vascular Ageing","JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN","Life expectancy in the European Union is rising and the prevalence of age-induced cardiovascular disease increases concomitantly. Endothelial dysfunction is a hallmark of aging in the vasculature and is the underlying cause of many cardiovascular disorders, like hypertension, acute myocardial infarction and stroke. This proposal aims to better understand the molecular mechanisms behind aging that lead to endothelial dysfunction.Non-coding RNAs are emerging as novel key regulators of cellular fun",{"id":904,"funder":7,"programme":8,"title":905,"piName":10,"institution":906,"country":62,"year":13,"amount":51,"abstract":907},"cordis-european-research-council-award-637308","3D Scaffolds as a Stem Cell Delivery System for Musculoskeletal Regenerative Medicine","UNIVERSITEIT MAASTRICHT","Aging worldwide population demands new solutions to permanently restore damaged tissues, thus reducing healthcare costs. Regenerative medicine offers alternative therapies for tissue repair. Although first clinical trials revealed excellent initial response after implantation of these engineered tissues, long-term follow-ups demonstrated that degeneration and lack of integration with the surrounding tissues occur. Causes are related to insufficient cell-material interactions and loss of cell pot",{"id":909,"funder":7,"programme":8,"title":910,"piName":10,"institution":911,"country":27,"year":13,"amount":912,"abstract":913},"cordis-european-research-council-award-637853","Injectable anisotropic microgel-in-hydrogel matrices for spinal cord repair","DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV","€1,435,396","This project will engineer an injectable biomaterial that forms an anisotropic microheterogeneous structure in vivo. Injectable hydrogels enable a minimal invasive in situ generation of matrices for the regeneration of tissues and organs, but currently lack structural organization and unidirectional orientation. The anisotropic, injectable hydrogels to be developed will mimic local extracellular matrix architectures that cells encounter in complex tissues (e.g. nerves, muscles). This project aim",{"id":915,"funder":7,"programme":8,"title":916,"piName":10,"institution":917,"country":286,"year":13,"amount":10,"abstract":918},"cordis-european-research-council-award-636928","Revealing the function of dormant soil microorganisms and the cues for their awakening","UNIVERSITAT WIEN","Soils are considered the last scientific frontiers that harbor one of the most diverse microbial communities on Earth. It is hypothesized that this diversity allows for redundancy in microbial key processes, thereby ensuring ecosystem stability. Much of this functional redundancy is embodied in non-active, dormant microorganisms that represent the ‘microbial seed bank’, which is characterized by a high number of low abundant taxa. Based on the recent theory of a ‘dynamic rank-abundance curve’, i",{"id":920,"funder":7,"programme":8,"title":921,"piName":10,"institution":922,"country":27,"year":13,"amount":10,"abstract":923},"cordis-european-research-council-award-638337","From Supramolecular Chemistry to Organocatalysis: Fundamental Studies on the Use of Little-Explored Non-Covalent Interactions in Organic Synthesis","RUHR-UNIVERSITAET BOCHUM","Hydrogen-bonds have found widespread use in various fields of chemistry, including supramolecular chemistry, organic chemistry, and more lately organocatalysis. Although a multitude of structurally different hydrogen-bond donors has been developed, their mode of action is in all cases necessarily based on the same interacting atom, hydrogen. In this proposal, we aim to develop first applications for two, previously very little explored non-covalent interactions that are based on electrophilic ha",{"id":925,"funder":7,"programme":8,"title":926,"piName":10,"institution":927,"country":928,"year":13,"amount":929,"abstract":930},"cordis-european-research-council-award-640557","Births, mothers and babies: prehistoric fertility in the Balkans between 10000 – 5000 BC","BIOSENSE INSTITUTE - RESEARCH AND DEVELOPMENT INSTITUTE FOR INFORMATION TECHNOLOGIES IN BIOSYSTEMS","RS","€1,714,880","The BIRTH project will investigate the key biological and cultural mechanisms affecting fertility rates resulting the Neolithic Demogaphic Transition, the major demographic shift in human evolution. We integrate skeletal markers with micro-nutritional and macro-scaled cultural effects on fertility rates during the Early-Middle Holocene (10000-5000 BC) in the Central Balkans. Human, animal and plant remains, will be analysed using methods from bioarchaeological, forensic, chemical sciences in ord",{"id":932,"funder":7,"programme":8,"title":933,"piName":10,"institution":934,"country":27,"year":13,"amount":935,"abstract":936},"cordis-european-research-council-award-639119","Observing structural dynamics at surfaces with Ultrafast Low-Energy Electron Diffraction","GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS","€1,479,750","This grant application proposes the establishment of Ultrafast Low-Energy Electron Diffraction (ULEED) as a novel and versatile approach to investigate ultrafast structural dynamics at surfaces and in ultrathin films. Two-dimensional systems such as surfaces and molecular monolayers exhibit a multitude of intriguing phases and complex transitions. Studying the ultrafast dynamics of these materials elucidates correlations and microscopic couplings, but the access to structural degrees of freedom ",{"id":938,"funder":7,"programme":8,"title":939,"piName":10,"institution":940,"country":286,"year":13,"amount":941,"abstract":942},"cordis-european-research-council-award-639478","Mechanisms of Auxin-dependent Signaling in the Endoplasmic Reticulum","UNIVERSITAET FUER BODENKULTUR WIEN","€1,441,125","The phytohormone auxin has profound importance for plant development. The extracellular AUXIN BINDING PROTEIN1 (ABP1) and the nuclear AUXIN F-BOX PROTEINs (TIR1\u002FAFBs) auxin receptors perceive fast, non-genomic and slow, genomic auxin responses, respectively. Despite the fact that ABP1 mainly localizes to the endoplasmic reticulum (ER), until now it has been proposed to be active only in the extracellular matrix (reviewed in Sauer and Kleine-Vehn, 2011). Just recently, ABP1 function was also link",{"id":944,"funder":7,"programme":8,"title":945,"piName":10,"institution":280,"country":150,"year":13,"amount":946,"abstract":947},"cordis-european-research-council-award-638765","Quantum Cavity Electro- and Opto-Mechanics","€1,495,073","Nanomechanical oscillators have recently been realised in the quantum regime, by coupling them to a single mode of the electromagnetic field. Platforms using both superconducting microwave circuits and optical cavities have been employed—separately—for this purpose. Based on the PI's extensive contributions to these developments, we propose to explore the intriguing conceptual and experimental prospects of hybrid multimode systems involving microwave, mechanical and optical modes in the quantum ",{"id":949,"funder":7,"programme":8,"title":950,"piName":10,"institution":183,"country":27,"year":13,"amount":951,"abstract":952},"cordis-european-research-council-award-638528","New avenues towards solving the dark matter puzzle","€1,214,250","It is now firmly established that most of the matter in the Universe is in the form of the mysterious dark matter,contributing more than 80% to the total amount of matter. However, despite tremendous theoretical andexperimental efforts over the past few decades, dark matter remains elusive and one of the great unknownsuntil today. To identify the nature of dark matter is evidently of fundamental importance and one of thetop priorities in science today. The quest for dark matter is inherently mul",{"id":954,"funder":7,"programme":8,"title":955,"piName":10,"institution":956,"country":34,"year":13,"amount":957,"abstract":958},"cordis-european-research-council-award-637776","Algal Lipids: the Key to Earth Now and aNcient Earth","UNIVERSITY OF GLASGOW","€940,883","Alkenones are algal lipids that have been used for decades to reconstruct quantitative past sea surface temperature. Although alkenones are being discovered in an increasing number of lake sites worldwide, only two terrestrial temperature records have been reconstructed so far. The development of this research field is limited by the lack of interdisciplinary research that combines modern biological and ecological algal research with the organic geochemical techniques needed to develop a quantit",{"id":960,"funder":7,"programme":8,"title":961,"piName":10,"institution":712,"country":62,"year":13,"amount":962,"abstract":963},"cordis-european-research-council-award-639217","The physics and forensics of neutron star explosions","€1,499,999","Neutron stars offer a unique environment in which to develop and test theories of the strong force. Densities in neutron star cores can reach up to ten times the density of a normal atomic nucleus, and the stabilizing effect of gravitational confinement permits long-timescale weak interactions.  This generates matter that is neutron-rich, and opens up the possibility of stable states of strange matter, something that can only exist in neutron stars. Strong force physics is encoded in the Equatio",{"id":965,"funder":7,"programme":8,"title":966,"piName":10,"institution":967,"country":34,"year":13,"amount":968,"abstract":969},"cordis-european-research-council-award-638707","Black holes and their host galaxies: coevolution across cosmic time","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€1,975,062","Galaxy formation is one of the most fascinating yet challenging fields of astrophysics. The desire to understandgalaxy formation has led to the design of ever more sophisticated telescopes which show a bewildering varietyof galaxies in the Universe. However, the degree to which an interpretation of this wealth of data can succeeddepends critically on having accurate and realistic theoretical models of galaxy formation. While cosmologicalsimulations of galaxy formation provide the most powerful t",{"id":971,"funder":7,"programme":8,"title":972,"piName":10,"institution":660,"country":27,"year":13,"amount":973,"abstract":974},"cordis-european-research-council-award-639096","Genetic Mapping of Evolutionary Developmental Variation using Hybrid Mouse in vitro Crosses","€1,499,923","Discovering the genetic changes underlying species differences is a central goal in evolutionary genetics. Most evolutionarily important traits affecting fitness are complex or quantitative traits, whose genetic bases are elusive. In mammals, dissecting the genetic basis of complex trait variation is particularly challenging, because efficient genetic mapping requires enormous pedigrees or specialized genetic panels that are typically beyond the resources of individual groups. Using a radically ",{"id":976,"funder":7,"programme":8,"title":977,"piName":10,"institution":724,"country":265,"year":13,"amount":370,"abstract":978},"cordis-european-research-council-award-637928","Tunneling Spectroscopy in van-der-Waals Device","I will expand the experimental reach of tunneling spectroscopy to new materials and device geometries. The technique is ideal for tackling two challenges: (i) Probing Andreev bound states and Majorana states in graphene and topological insulators (TIs) coupled to superconductors, and (ii) realizing momentum-conserving tunneling.I will utilize a breakthrough in device fabrication to stack layered van-der-Waals materials, such as graphene and hexagonal Boron Nitride (hBN), to form vertical structu",{"id":980,"funder":7,"programme":8,"title":981,"piName":10,"institution":271,"country":265,"year":13,"amount":51,"abstract":982},"cordis-european-research-council-award-636752","An integrative approach to uncover the multilevel regulation of 20S proteasome degradation","For many years, the ubiquitin-26S proteasome degradation pathway was considered the primary route for proteasomal degradation. However, it is now becoming clear that proteins can also be targeted for degradation by a ubiquitin-independent mechanism mediated by the core 20S proteasome itself. Although initially believed to be limited to rare exceptions, degradation by the 20S proteasome is now understood to have a wide range of substrates, many of which are key regulatory proteins. Despite its im",{"id":984,"funder":7,"programme":8,"title":985,"piName":10,"institution":986,"country":34,"year":13,"amount":987,"abstract":988},"cordis-european-research-council-award-638426","Beyond genotype to phenotype: how ancestor lifestyle impacts on lifespan variation in descendants","THE BABRAHAM INSTITUTE","€1,499,978","There are many examples in nature where inter-individual variability in life-history traits is exploited as an adaptive strategy. I and others have shown that inter-individual variability in the longevity pathways –and in particular, in stress response genes- has consequences for genetic\u002Fenvironmental phenotypic robustness as well as for lifespan in Caenorhabditis elegans. My main interest is to uncover the causes that explain inter-individual variability in lifespan. The variability across indi",{"id":990,"funder":7,"programme":8,"title":991,"piName":10,"institution":992,"country":62,"year":13,"amount":993,"abstract":994},"cordis-european-research-council-award-637024","The heart of stroke: Pipes, Perfusion, Parenchyma","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","€1,499,450","My aim is to understand the cause of stroke in every single patient. Brain microinfarcts and macroinfarcts cause a major healthcare burden in Western societies both in terms of morbidity and costs. Cardiovascular thromboemboli from the heart, aorta and neck arteries are considered as the main cause. Still, the vast majority of brain infarcts are unexplained. In contrast to the thromboembolic explanation for brain infarcts, heart infarcts are known to be caused by local atherosclerotic plaque of ",{"id":996,"funder":7,"programme":8,"title":997,"piName":10,"institution":339,"country":293,"year":13,"amount":998,"abstract":999},"cordis-european-research-council-award-639668","Agents of Change: Women Editors and Socio-Cultural Transformation in Europe (1710-1920)","€1,495,000","This project examines a neglected aspect of the social and cultural life in Europe in the modern period: the impact of women editors on public debate. From the 1700s on, European women actively participated in the cultural arena through the journals that they edited. This project advances the hypothesis that periodical editorship enabled these women to take a prominent role in public life, to influence public opinion and to shape transnational processes of change. In order to test this hypothesi",{"id":1001,"funder":7,"programme":8,"title":1002,"piName":10,"institution":595,"country":265,"year":13,"amount":697,"abstract":1003},"cordis-european-research-council-award-633509","Quasi-Randomness in Extremal Combinatorics","Combinatorics is an extremely fast growing mathematical discipline. While it started as a collection of isolated problems thatwere tackled using ad-hoc arguments it has since grown into a mature discipline which both incorporated into it deep tools from other mathematical areas, and has also found applications in other mathematical areas such as Additive Number Theory, Theoretical Computer Science, Computational Biology and Information Theory.The PI will work on a variety of problems in Extremal",{"id":1005,"funder":7,"programme":8,"title":1006,"piName":10,"institution":1007,"country":80,"year":13,"amount":10,"abstract":1008},"cordis-european-research-council-award-640283","2D Conformal mapping of protein surfaces: applications to VIsualization and DOCKing software","CONSERVATOIRE NATIONAL DES ARTS ET METIERS","The goals of structural biology include developing a comprehensive understanding of the molecular shapes and forms embraced by biological macromolecules and extending this knowledge to understand how different molecular architectures are used to perform the chemical reactions that are central to life. Since the first resolution of protein structures by X-ray crystallography and NMR, structural biology seeks to provide this picture of biological phenomena at the molecular and atomic level by anal",{"id":1010,"funder":7,"programme":8,"title":1011,"piName":10,"institution":1012,"country":12,"year":13,"amount":1013,"abstract":1014},"cordis-european-research-council-award-638809","An Illumination of the Dark Ages: modeling reionization and interpreting observations","SCUOLA NORMALE SUPERIORE","€1,468,750","Understanding the dawn of the first galaxies and how their light permeated the early Universe is at the very frontier of modern astrophysical cosmology.  Generous resources, including ambitions observational programs, are being devoted to studying these epochs of Cosmic Dawn (CD) and Reionization (EoR).  In order to interpret these observations, we propose to build on our widely-used, semi-numeric simulation tool, 21cmFAST, and apply it to observations.  Using sub-grid, semi-analytic models, we ",{"id":1016,"funder":7,"programme":8,"title":1017,"piName":10,"institution":660,"country":27,"year":13,"amount":1018,"abstract":1019},"cordis-european-research-council-award-636201","Wavefunctions for strongly correlated systems","€1,338,500","Strongly correlated quantum systems, which are at the heart of many open problems in condensed matter,quantum chemistry, or high-energy physics, are challenging to understand due to their intricate entanglementstructure. Quantum information theory provides the right framework to characterize highly entangledstates and has given rise to the class of Tensor Network States, which capture the entanglement structure ofstrongly correlated systems by building the global wavefunction from local tensors ",{"id":1021,"funder":7,"programme":8,"title":1022,"piName":10,"institution":1023,"country":642,"year":13,"amount":51,"abstract":1024},"cordis-european-research-council-award-639720","Nanoporous Asymmetric Poly(Ionic Liquid) Membrane","STOCKHOLMS UNIVERSITET","Nanoporous polymer membranes (NPMs) play a crucial, irreplaceable role in fundamental research and industrial usage, including separation, filtration, water treatment and sustainable environment. The vast majority of advances concentrate on neutral or weakly charged polymers, such as the ongoing interest on self-assembled block copolymer NPMs. There is an urgent need to process polyelectrolytes into NPMs that critically combine a high charge density with nanoporous morphology. Additionally, engi",{"id":1026,"funder":7,"programme":8,"title":1027,"piName":10,"institution":1028,"country":20,"year":13,"amount":1029,"abstract":1030},"cordis-european-research-council-award-635919","Functional materials from on-surface linkage of molecular precursors","FUNDACION DONOSTIA INTERNATIONAL PHYSICS CENTER","€1,894,723","With the advent of self-assembly, increasingly high hopes are being placed on supramolecular materials as future active components of a variety of devices. The main challenge remains the design and assembly of supramolecular structures with emerging functionalities tailored according to our needs. In this respect, the extensive research over the last decades has led to impressive progress in the self-assembly of molecular structures. However, self-assembly typically relies on non-covalent intera",{"id":1032,"funder":7,"programme":8,"title":1033,"piName":10,"institution":1034,"country":27,"year":13,"amount":1035,"abstract":1036},"cordis-european-research-council-award-640087","Sorting of Self","UNIVERSITATSKLINIKUM ERLANGEN","€1,479,781","During inflammation and infection, we are simultaneously confronted with both self and non-self in form of dying cells and microbes, respectively. Mechanisms that facilitate the non-immunogenic clearance of self-antigens derived from apoptotic and necrotic cells and that, in parallel, allow the initiation of an immune response against invading pathogens are incompletely understood. Recent data from our laboratory show that the immune system actively sorts apoptotic cells (ACs) and bacteria into ",{"id":1038,"funder":7,"programme":8,"title":1039,"piName":10,"institution":1040,"country":293,"year":13,"amount":51,"abstract":1041},"cordis-european-research-council-award-640130","Searching for The Origin of Cosmic Rays and Neutrinos with LOFAR","VRIJE UNIVERSITEIT BRUSSEL","The origin of cosmic rays remains one of the largest mysteries in astrophysics. Innovative and accurate radio measurements of cosmic rays and neutrinos with LOFAR promise to provide new answers.It is generally believed that ultra-high-energy cosmic rays are produced in extragalactic sources like gamma- ray bursts or active galactic nuclei, while the lower energy cosmic rays come from our own Galaxy. At what energy this transition takes place is still unknown. Here we focus on disentangling Galac",{"id":1043,"funder":7,"programme":8,"title":1044,"piName":10,"institution":1045,"country":62,"year":13,"amount":51,"abstract":1046},"cordis-european-research-council-award-639776","Commitment, maturation and infectivity of sexual stage malaria parasites in natural infections","STICHTING RADBOUD UNIVERSITEIT","Background: One of the major challenges for malaria control and elimination is the phenomenally efficient spread of malaria through sexual stage malaria parasites (gametocytes). The epidemiology and dynamics of gametocytes are poorly understood: it is presently unknown when commitment to gametocytes first occurs during infections and what intrinsic or extrinsic factors influence gametocyte production and infectivity to mosquitoes. I hypothesize that continuous early commitment to gametocyte prod",{"id":1048,"funder":7,"programme":8,"title":1049,"piName":10,"institution":1050,"country":27,"year":13,"amount":51,"abstract":1051},"cordis-european-research-council-award-637860","The mechanism of sleep control through a sleep-active sleep-promoting neuron","TECHNISCHE UNIVERSITAET DRESDEN","Sleep is essential for human and animal life and is broadly conserved. The nervous system induces sleep through the activation of sleep-active sleep-promoting neurons but the key mechanisms of sleep control remain to be elucidated. Recent work from my lab showed that the C. elegans nervous system contains a single sleep-active sleep-promoting neuron, called RIS, which is GABAergic and peptidergic as is its vertebrate counterpart. C. elegans shows sleep behavior and allows the easy combination of",{"id":1053,"funder":7,"programme":8,"title":1054,"piName":10,"institution":271,"country":265,"year":13,"amount":51,"abstract":1055},"cordis-european-research-council-award-638644","Deciphering the role of adult neurogenesis in hippocampal memory codes by optically imaging neuronal activity in freely behaving mice","The hippocampal dentate gyrus (DG) is one of the few areas in the adult mammalian brain that exhibits neurogenesis, the continuous generation of new neurons. Much evidence indicates that adult neurogenesis contributes to hippocampal-dependent cognition, but the nature of this contribution remains elusive. I envisioned that the clearest path towards understanding the function of adult neurogenesis would be to reveal the changes that occur in the coding properties of DG neurons throughout their de",{"id":1057,"funder":7,"programme":8,"title":1058,"piName":10,"institution":1059,"country":62,"year":13,"amount":51,"abstract":1060},"cordis-european-research-council-award-638428","Robot-Assisted Flexible Needle Steering for Targeted Delivery of Magnetic Agents","UNIVERSITEIT TWENTE","Diagnostic agents are currently injected into the body in an uncontrolled way and visualized using non-real-time imaging modalities. Delivering agents close to the organ and magnetically guiding them to the target would permit a myriad of novel diagnostic and therapeutic options, including on-site pathology and targeted drug delivery. Such an advance would truly revolutionize minimally invasive surgery (MIS). Presently MIS often involves manual percutaneous insertion of rigid needles. These need",{"id":1062,"funder":7,"programme":8,"title":1063,"piName":10,"institution":922,"country":27,"year":13,"amount":10,"abstract":1064},"cordis-european-research-council-award-640110","Leveraging Binary Analysis to Secure the Internet of Things","We are in the midst of the shift towards the Internet of Things (IoT), where more and more (legacy) devices are connected to the Internet and communicate with each other.  This paradigm shift brings new security challenges and unfortunately many current security solutions are not applicable anymore, e.g., because of a lack of clear network boundaries or resource-constrained devices. However, security plays a central role: In addition to its classical function in protecting against manipulation a",{"id":1066,"funder":7,"programme":8,"title":1067,"piName":10,"institution":595,"country":265,"year":13,"amount":1068,"abstract":1069},"cordis-european-research-council-award-639573","An Information Theory of Simple Interaction","€1,323,875","Motivated by our recent progress in feedback information theory and its deep relations to stochastic dynamical systems, and inspired by natural phenomena such as bio-molecular interactions and human conversation, this research will explore the fundamental limits of information transfer via simple interaction. In the standard information theoretic framework, the problem of reliable communications is typically studied in an asymptotic unidirectional regime, where optimal performance is attained vi",200,{"programme":8,"total":1072,"withPiName":1073,"firstYear":1074,"lastYear":1075,"countryCount":1076,"perYear":1077,"topInstitutions":1135,"topCountries":1205},7919,572,2008,2027,52,[1078,1080,1083,1086,1089,1092,1095,1098,1100,1103,1106,1109,1112,1115,1118,1121,1124,1127,1130,1133],{"year":1074,"count":1079},279,{"year":1081,"count":1082},2009,157,{"year":1084,"count":1085},2010,302,{"year":1087,"count":1088},2011,447,{"year":1090,"count":1091},2012,524,{"year":1093,"count":1094},2013,456,{"year":1096,"count":1097},2014,297,{"year":13,"count":1099},366,{"year":1101,"count":1102},2016,376,{"year":1104,"count":1105},2017,419,{"year":1107,"count":1108},2018,582,{"year":1110,"count":1111},2019,393,{"year":1113,"count":1114},2020,384,{"year":1116,"count":1117},2021,394,{"year":1119,"count":1120},2022,514,{"year":1122,"count":1123},2023,512,{"year":1125,"count":1126},2024,473,{"year":1128,"count":1129},2025,482,{"year":1131,"count":1132},2026,556,{"year":1075,"count":1134},6,[1136,1138,1141,1144,1146,1149,1152,1155,1158,1161,1164,1166,1169,1172,1175,1178,1181,1184,1186,1188,1191,1193,1196,1199,1202],{"name":1137,"count":1117},"Centre National de la Recherche Scientifique CNRS",{"name":1139,"count":1140},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",175,{"name":1142,"count":1143},"University of Cambridge",129,{"name":1145,"count":1143},"University of Oxford",{"name":1147,"count":1148},"Hebrew University of Jerusalem",112,{"name":1150,"count":1151},"University College London",110,{"name":1153,"count":1154},"Tel Aviv University",107,{"name":1156,"count":1157},"Weizmann Institute of Science",104,{"name":1159,"count":1160},"Eidgenoessische Technische Hochschule Zuerich",87,{"name":1162,"count":1163},"Kobenhavns Universitet",85,{"name":1165,"count":1163},"Universiteit Gent",{"name":1167,"count":1168},"Universiteit van Amsterdam",84,{"name":1170,"count":1171},"École Polytechnique Fédérale de Lausanne",83,{"name":1173,"count":1174},"Ludwig-Maximilians-Universitaet Muenchen",82,{"name":1176,"count":1177},"Institut National de la Sante Et de la Recherche Medicale",78,{"name":1179,"count":1180},"Universiteit Utrecht",76,{"name":1182,"count":1183},"Imperial College of Science Technology and Medicine",71,{"name":1185,"count":1183},"Katholieke Universiteit Leuven",{"name":1187,"count":1183},"Technische Universiteit Delft",{"name":1189,"count":1190},"Technion - Israel Institute of Technology",70,{"name":1192,"count":1190},"Technische Universitaet Muenchen",{"name":1194,"count":1195},"Universiteit Leiden",69,{"name":1197,"count":1198},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",67,{"name":1200,"count":1201},"The University of Edinburgh",64,{"name":1203,"count":1204},"Helsingin Yliopisto",57,[1206,1208,1210,1212,1214,1215,1217,1219,1222,1224,1226,1228,1230,1232,1233,1235,1237,1240,1243,1246,1249,1252,1255,1257,1260],{"name":27,"count":1207},1346,{"name":34,"count":1209},1007,{"name":80,"count":1211},932,{"name":62,"count":1213},772,{"name":12,"count":1123},{"name":20,"count":1216},475,{"name":265,"count":1218},470,{"name":1220,"count":1221},"CH",389,{"name":293,"count":1223},348,{"name":642,"count":1225},291,{"name":286,"count":1227},269,{"name":150,"count":1229},189,{"name":300,"count":1231},137,{"name":555,"count":1151},{"name":528,"count":1234},108,{"name":357,"count":1236},92,{"name":1238,"count":1239},"GB",68,{"name":1241,"count":1242},"PL",60,{"name":1244,"count":1245},"CZ",43,{"name":1247,"count":1248},"EL",41,{"name":1250,"count":1251},"US",36,{"name":1253,"count":1254},"HU",32,{"name":870,"count":1256},24,{"name":1258,"count":1259},"SI",14,{"name":1261,"count":1262},"EE",10]