[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-starting-grant-2016":3,"awarded-stats-erc-starting-grant":1092},{"awarded":4,"total":1091},[5,16,22,27,32,37,44,51,57,61,66,71,76,83,87,93,98,103,109,116,123,129,134,141,147,154,160,165,172,178,184,190,196,202,207,213,218,223,228,233,239,243,248,253,258,262,267,272,278,284,289,294,300,304,310,316,322,328,333,338,344,349,354,359,366,371,376,382,388,393,398,403,408,413,418,423,429,434,439,443,448,453,459,464,470,476,481,485,491,497,504,510,515,521,528,533,539,545,552,558,564,569,574,579,585,591,597,603,608,614,618,624,630,636,641,646,651,656,662,668,673,679,684,690,695,700,705,709,714,720,725,730,736,741,746,750,757,762,767,771,776,782,787,793,798,803,807,812,818,822,827,831,837,843,848,854,860,865,871,876,881,886,892,897,902,908,914,919,924,929,935,941,947,952,957,962,967,971,977,982,987,993,998,1004,1009,1015,1019,1025,1030,1034,1039,1044,1050,1056,1061,1067,1073,1077,1081,1086],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-679479","European Research Council","ERC Starting Grant","Chemical biology approaches to unraveling the histone code",null,"UNIVERSITY OF NEWCASTLE UPON TYNE","UK",2016,"€1,758,846","Posttranslational modifications on histones play crucial roles in the epigenetic regulation of eukaryotic gene expression. Chemical modifications that occur on histone tails include acetylation, methylation, phosphorylation, ubiquitination, and SUMOylation. This chemical diversity together with the positions and combinations of these modifications give rise to complex networks of highly controlled gene expression programs. The identification and characterisation of chromatin-associated proteins ",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":12,"year":13,"amount":20,"abstract":21},"cordis-european-research-council-award-676861","External Control of Liquid Nanofilms for Switchable Friction and Adhesion","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€1,492,828","The overall vision of the project is to demonstrate methods for switching friction and adhesion – such as “switch off friction” or “switch on adhesion” – reversibly and with remote control. My hypothesis is that fluids confined to nanofilms between solid objects can be designed to dramatically alter their surface properties under the influence of applied fields, and so can be used to switch friction, lubrication or adhesion in a controlled and reversible way. The emphasis of the project is on cr",{"id":23,"funder":7,"programme":8,"title":24,"piName":10,"institution":19,"country":12,"year":13,"amount":25,"abstract":26},"cordis-european-research-council-award-676632","Randomness and pseudorandomness in discrete mathematics","€1,106,719","Discrete mathematics has seen enormous advances in the last few years, with solutions being found to a number of famous and long-standing questions, such as the Erdos distinct distance problem and the existence conjecture for combinatorial designs. Much of this progress owes to an increased understanding of random and pseudorandom objects. An entire framework, known as the probabilistic method, has grown around the application of randomness to combinatorial problems, while pseudorandomness is pl",{"id":28,"funder":7,"programme":8,"title":29,"piName":10,"institution":19,"country":12,"year":13,"amount":30,"abstract":31},"cordis-european-research-council-award-677774","Terrestrial vertebrates and the evolutionary origins of morphological diversity","€1,499,496","Explaining the great disparity of organismal form is a central goal of biological research. However, despite many decades of inquiry, there is little understanding of how evolution gave rise to this disparity. Key hypotheses predict changes in macroevolutionary modes through geological time: rates of evolution may either have decreased as global niche space became crowded, or increased due to accumulation of key innovations that improve body plan versatility. The absence of data to test these hy",{"id":33,"funder":7,"programme":8,"title":34,"piName":10,"institution":19,"country":12,"year":13,"amount":35,"abstract":36},"cordis-european-research-council-award-674978","Low-dimensional topology in Oxford","€1,497,422","This project aims to build a group that brings together experts in gauge-theoretic, geometric, and group-theoretic techniques. It consists of 4 branches. 1. Cobordism maps in knot Floer homology (HFK). Defined by the PI, these should yield invariants of surfaces in 4-manifolds. Hence, they could be used to bound the 4-ball genus and the unknotting number, providing a tool for finding a counterexample to the smooth 4-dimensional Poincaré conjecture, and to decide whether a given slice knot bounds",{"id":38,"funder":7,"programme":8,"title":39,"piName":10,"institution":40,"country":41,"year":13,"amount":42,"abstract":43},"cordis-european-research-council-award-677139","Plant adaptations to unpredictable attack by dynamic insect communities","WAGENINGEN UNIVERSITY","NL","€1,500,000","Individual plants are exposed to many stresses with insect herbivores being a prominent one. The occurrence of insect herbivores may be unpredictable in terms of when, by which species, and in which order the attack will take place. To deal with unpredictability of attack, plants are phenotypically plastic in their defence. They respond to attackers with the induction of specific defences and saving costs of defence in their absence. However, the induced plant phenotype may attract additional he",{"id":45,"funder":7,"programme":8,"title":46,"piName":10,"institution":47,"country":48,"year":13,"amount":49,"abstract":50},"cordis-european-research-council-award-678304","Learning spatiotemporal patterns in longitudinal image data sets of the aging brain","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","FR","€1,499,894","Time-series of multimodal medical images offer a unique opportunity to track anatomical and functional alterations of the brain in aging individuals. A collection of such time series for several individuals forms a longitudinal data set, each data being a rich iconic-geometric representation of the brain anatomy and function. These data are already extraordinary complex and variable across individuals. Taking the temporal component into account further adds difficulty, in that each individual fo",{"id":52,"funder":7,"programme":8,"title":53,"piName":10,"institution":54,"country":48,"year":13,"amount":55,"abstract":56},"cordis-european-research-council-award-679030","WHat next? an Integrated PLanetary Atmosphere Simulator: from Habitable worlds to Hot jupiters","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€1,480,421","Thousands of exoplanets have now been found. In the next decade, the grand challenge is to characterize their atmospheres. This is the only way to unravel the origin of the wild, unexpected diversity we have uncovered. For this task, there are several planned missions—JWST being our next best opportunity. However, to be ready for the analysis and interpretation of such high-precision observations, we need new-generation tools fit to address the multiple challenges they will raise. Indeed, until ",{"id":58,"funder":7,"programme":8,"title":59,"piName":10,"institution":54,"country":48,"year":13,"amount":10,"abstract":60},"cordis-european-research-council-award-678777","Towards Innovative cost-effective astronomical instrumentation","Enabling disruptive technologies has always been crucial to trigger revolutionary science discoveries. The daring challenges in astronomy and astrophysics are extremely demanding in terms of high angular resolution and high contrast imaging, and require extreme stability and image quality. Instruments based on current classical designs tend to get bigger and more complex, and are faced to ever increasing difficulties to meet science requirements.This proposal has the clear objective to propose b",{"id":62,"funder":7,"programme":8,"title":63,"piName":10,"institution":54,"country":48,"year":13,"amount":64,"abstract":65},"cordis-european-research-council-award-678157","Coinduction for Verification and Certification","€1,407,413","Software and hardware bugs cost hundreds of millions of euros every year to companies and administrations. Formal methods like verification provide automatic means of finding some of these bugs. Certification, using proof assistants like Coq or Isabelle\u002FHOL, make it possible to guarantee the absence of bugs (up to a certain point).These two kinds of tools are crucial in order to design safer programs and machines. Unfortunately, state-of-the art tools are not yet satisfactory. Verification tools",{"id":67,"funder":7,"programme":8,"title":68,"piName":10,"institution":54,"country":48,"year":13,"amount":69,"abstract":70},"cordis-european-research-council-award-678140","Fluctuating selection, evolution, and plasticity in random environments","€1,499,665","Temporal environmental variation in natural systems includes a large component of random fluctuations, the magnitude and predictability of which is modified under current climate change. The need for predicting eco-evolutionary impacts of plastic and evolutionary responses to changing environments is still hampered by lack of strong experimental evidence. FluctEvol aims at shedding a new light on population responses to stochastic environments, and facilitating their prediction, using a unique c",{"id":72,"funder":7,"programme":8,"title":73,"piName":10,"institution":54,"country":48,"year":13,"amount":74,"abstract":75},"cordis-european-research-council-award-680275","A mathematical approach to the liquid-glass transition: kinetically constrained models, cellular automata and mixed order phase transitions","€883,250","This proposal focuses on the mathematics of three cross-disciplinary, very active and deeply interlaced research themes:  interacting particle systems with kinetic constraints, bootstrap percolation cellular automata and mixed order phase transitions. These topics belong to the fertile area of mathematics at the intersection of probability and mathematical statistical mechanics. They are also extremely important in physics. Indeed they are intimately connected to the fundamental problem of under",{"id":77,"funder":7,"programme":8,"title":78,"piName":10,"institution":79,"country":80,"year":13,"amount":81,"abstract":82},"cordis-european-research-council-award-640448","The retinae as windows to the brain: An oscillatory vision","AARHUS UNIVERSITET","DK","€1,499,850","Several sophisticated image processing circuits have been discovered in the animal retina, many of which manifest massive neural synchrony. A major insight is that this type of synchrony often translates to high-frequency activity on a macroscopic level, but electroretinography (ERG) has not been tapped to examine this potential in humans. Bolstered by our compelling results combining ERG with magnetoencephalography (MEG), this project will address several open questions with respect to human vi",{"id":84,"funder":7,"programme":8,"title":85,"piName":10,"institution":79,"country":80,"year":13,"amount":42,"abstract":86},"cordis-european-research-council-award-679714","Synaptic Tagging and Capture: From Synapses to Behavior","It is shown that long-term potentiation (LTP) is the cellular basis of memory formation. However, since all but small fraction of memories are forgotten, LTP has been further divided into early LTP (e-LTP), the mechanism by which short-term memories are formed, and a more stable late LTP (L-LTP), by which long-term memories are formed. Remarkably, it has been shown that an e-LTP can be stabilized if it is preceded or followed by heterosynaptic L-LTP.According to Synaptic Tagging and Capture (STC",{"id":88,"funder":7,"programme":8,"title":89,"piName":10,"institution":90,"country":48,"year":13,"amount":91,"abstract":92},"cordis-european-research-council-award-678302","Shaping of axonal complexity by a dynamic regulation of local metabolic pathways in the developing cortex","UNIVERSITE LYON 1 CLAUDE BERNARD","€1,300,000","The proper function of neuronal circuits in the adult brain relies heavily on glucose metabolism to ensure energy-demanding neuronal functions such as synaptic activity or long distance axonal transport. Deregulation of the energetic metabolism is strongly associated to many neurodegenerative diseases and has been linked to some neuropsychiatric diseases such as schizophrenia. However our current understanding of metabolic regulation in the developing brain and in particular in rapidly growing n",{"id":94,"funder":7,"programme":8,"title":95,"piName":10,"institution":96,"country":48,"year":13,"amount":42,"abstract":97},"cordis-european-research-council-award-677251","Cell intrinsic control of CD4 T cell differentiation by cytosolic DNA sensing pathways","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","This proposal aims to investigate the role of cytosolic DNA sensing pathways in CD4 T cell differentiation.Cellular host defense to pathogens relies on the detection of pathogen-associated molecular patterns including deoxyribonucleic acid (DNA), which can be recognized by host myeloid cells through Toll-like receptor (TLR) 9 binding. Recent evidence however suggests that innate immune cells can also perceive cytoplasmic DNA from infectious or autologous origin through cytosolic DNA sensors trig",{"id":99,"funder":7,"programme":8,"title":100,"piName":10,"institution":96,"country":48,"year":13,"amount":101,"abstract":102},"cordis-european-research-council-award-678905","Cofactor Binding Antibodies – Basic Aspects and Therapeutic Innovations","€1,255,000","The immune repertoire of healthy individuals contains a fraction of antibodies (Abs) that are able to bind with high affinity various endogenous or exogenous low molecular weight compounds, including cofactors essential for the aerobic life, such as riboflavin, heme and ATP. Despite identification of cofactor-binding Abs as a constituent of normal immune repertoires, their fundamental characteristics and have not been systematically investigated. Thus, we do not know the origin, prevalence and p",{"id":104,"funder":7,"programme":8,"title":105,"piName":10,"institution":106,"country":48,"year":13,"amount":107,"abstract":108},"cordis-european-research-council-award-679836","Statistical modelling across price and time scales: a quantitative approach to modern financial regulation","ECOLE POLYTECHNIQUE","€1,165,625","This project aims at providing a new quantitative approach to financial regulation, notably in the context of high frequency trading. The key idea of our method is to build relevant statistical models through price and time scales, connecting the microstructure of financial markets to the long term behavior of prices.  Doing so, we will be able to understand and quantify the macroscopic consequences of regulatory measures modifying the microscopic design of the market. Succeeding in this modelli",{"id":110,"funder":7,"programme":8,"title":111,"piName":10,"institution":112,"country":113,"year":13,"amount":114,"abstract":115},"cordis-european-research-council-award-679068","Chromosomal Common Fragile Sites: Unravelling their biological functions and the basis of their instability","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","ES","€1,499,711","Cancer and other diseases are driven by genomic alterations initiated by DNA breaks. Within our genomes, some regions are particularly prone to breakage, and these are known as common fragile sites (CFSs). CFSs are present in every person and are frequently sites of oncogenic chromosomal rearrangements. Intriguingly, despite their fragility, many CFSs are well conserved through evolution, suggesting that these regions have important physiological functions that remain elusive. My previous backgr",{"id":117,"funder":7,"programme":8,"title":118,"piName":10,"institution":119,"country":120,"year":13,"amount":121,"abstract":122},"cordis-european-research-council-award-716087","NanoPlasmoMechanical Systems","TECHNISCHE UNIVERSITAET WIEN","AT","€1,497,550","With their unparalleled mass and force sensitivities, nanomechanical resonators have the potential toconsiderably improve existing sensor technology. However, one major obstacle still stands in the way oftheir practical use: The efficient transduction (actuation & detection) of the vibrational motion of such tinystructures. Localized plasmon resonances focus optical fields below the diffraction limit of light andpresent a powerful new method to optically transduce the vibrational motion of nanom",{"id":124,"funder":7,"programme":8,"title":125,"piName":10,"institution":126,"country":113,"year":13,"amount":127,"abstract":128},"cordis-european-research-council-award-679080","Using extreme magnetic field microscopy to visualize correlated electron materials","UNIVERSIDAD AUTONOMA DE MADRID","€1,704,375","Strong electronic correlations often produce intertwined phases where multiple length scales coexist. These produce spatially varying electronic properties containing unique insight on the many-body effects that determine the emergence of novel collective behavior. Addressing the problem of electron correlations requires powerful microscopes probing electronic properties down to atomic scale.A major challenge in electron correlated materials is to understand the emergence of high critical temper",{"id":130,"funder":7,"programme":8,"title":131,"piName":10,"institution":132,"country":12,"year":13,"amount":10,"abstract":133},"cordis-european-research-council-award-677927","ARgon ImAging DetectioN chambEr","THE UNIVERSITY OF LIVERPOOL","This proposal outlines a plan to combine Charge Couple Device (CCD) camera technologies with two-phase Liquid Argon Time Projection Chambers (LAr TPCs) utilising THick Gas Electron Multipliers (THGEMs) to evolve a next generation neutrino detector. This will be an entirely new readout option, and will open the prospect of revolutionary discoveries in fundamental particle physics. Furthermore, the Compton imaging power of this technology will be developed, which will have diverse applications in ",{"id":135,"funder":7,"programme":8,"title":136,"piName":10,"institution":137,"country":138,"year":13,"amount":139,"abstract":140},"cordis-european-research-council-award-678082","Bounded Rationality in Sensorimotor Coordination","UNIVERSITAET ULM","DE","€1,434,250","Despite their many successes and great computational power and speed, why are machines still so blatantly outperformed by humans in uncertain environments that require flexible sensorimotor behavior like playing football or navigating a disaster zone? Answering this question requires understanding the mathematical principles of biological sensorimotor control and learning. Over the recent years Bayes-optimal actor models have widely become the gold standard in the mathematical understanding of s",{"id":142,"funder":7,"programme":8,"title":143,"piName":10,"institution":144,"country":145,"year":13,"amount":42,"abstract":146},"cordis-european-research-council-award-678941","Single Nanoparticle Catalysis","CHALMERS TEKNISKA HOGSKOLA AB","SE","Imagine a sustainable society where clean energy is produced from sunlight, and water is converted into hydrogen to fuel a fuel cell, which produces electric energy to power the electric motor in a car. At the same time, CO2 emissions are captured and converted to hydrocarbons that are again used as fuel or as resource for fine chemical synthesis. At the heart of this vision is heterogeneous catalysis. Hence, for it to become reality, tailored highly efficient catalyst materials are of paramount",{"id":148,"funder":7,"programme":8,"title":149,"piName":10,"institution":150,"country":151,"year":13,"amount":152,"abstract":153},"cordis-european-research-council-award-678908","REstoring the Self with embodiable HAnd ProsthesEs","UNIVERSITA CAMPUS BIO MEDICO DI ROMA","IT","€1,490,750","Amputation distorts the body representation, a fundamental aspect of self-consciousness. Hand prostheses counteract sensorimotor impairment, but poor attention has been posed to target the alteration of body-image.RESHAPE aims to study prosthesis embodiment, identify what makes a hand prosthesis easily embodiable, and test non-invasive brain stimulation to facilitate the embodiment.Amputees claim to perceive prostheses as tools; RESHAPE enables amputees to project their self into the prosthesis,",{"id":155,"funder":7,"programme":8,"title":156,"piName":10,"institution":157,"country":158,"year":13,"amount":10,"abstract":159},"cordis-european-research-council-award-714118","Lab Based Searches for Beyond Standard Model Physics Using Traps","THE HEBREW UNIVERSITY OF JERUSALEM","IL","In this project I will measure a critical constant (beta-nu correlation) of the standard model to a precision of at least 0.1%, an order of magnitude improvement over the state of the art. The project will provide a platform for beyond standard-model (BSM) explorations, based on modern atom\u002Fion trapping and a new accelerator facility.High precision measurements of beta decay correlations in trapped radioactive atoms and ions are one of the most precise tools with which to search for BSM physics.",{"id":161,"funder":7,"programme":8,"title":162,"piName":10,"institution":157,"country":158,"year":13,"amount":163,"abstract":164},"cordis-european-research-council-award-676774","Practically Relevant Theory of Deep Learning","€1,342,500","One of the most significant recent developments in applied machine learning has been the resurgence of ``deep learning'', usually in the form of artificial neural networks.  The empirical success of deep learning is stunning, and deep learning based systems have already led to breakthroughs in computer vision and speech recognition. In contrast, from the theoretical point of view, by and large, we do not understand why deep learning is at all possible, since most state ofthe art theoretical resu",{"id":166,"funder":7,"programme":8,"title":167,"piName":10,"institution":168,"country":169,"year":13,"amount":170,"abstract":171},"cordis-european-research-council-award-678567","Plasmonically-enhanced III-V nanowire lasers on silicon for integrated communications","IBM RESEARCH GMBH","CH","€1,941,750","The ambition of PLASMIC is to address the bottleneck caused by electrical interconnects and develop on-chip optical interconnect solutions based on plasmonically-enhanced nanoscale emitters.Nanoscale photonic components are desirable for on-chip communications because of density, speed and because reducing the size of the cavity might reduce the lasing threshold. Conventional photonics are limited in scale by the diffraction-limit to dimensions of half of the wavelength of light in the material.",{"id":173,"funder":7,"programme":8,"title":174,"piName":10,"institution":175,"country":138,"year":13,"amount":176,"abstract":177},"cordis-european-research-council-award-677317","How and when was Japan settled by speakers of Japanese?  Exploring the clues to Japanese prehistory preserved in old dialect divisions","RUHR-UNIVERSITAET BOCHUM","€1,394,040","It is thought that the Japanese language was brought to Japan in a series of west-to-east migrations from the Korean peninsula in prehistoric times. Through fieldwork on the tone systems of a cluster of outlying and not sufficiently documented dialects in Japan (the so-called Gairin or ‘outer circle’ dialects), a genealogy of the members of this dialect group will be reconstructed. A central question is whether the similarities between the Gairin dialects are the result of parallel developments ",{"id":179,"funder":7,"programme":8,"title":180,"piName":10,"institution":181,"country":12,"year":13,"amount":182,"abstract":183},"cordis-european-research-council-award-680042","The molecular interface between cell cycle and redox regulation","INSTITUTE OF CANCER RESEARCH: THE ROYAL CANCER HOSPITAL LBG","€1,499,688","Aberrant cell cycle and redox regulation are hallmarks of cancer. While cell cycle and redox signaling are extensively studied, it remains poorly understood how both communicate in physiological conditions. One reason is the emphasis on oxidative stress as a signature of cancer cells. Only recently, emerging evidence indicates that reactive oxygen species (ROS) also function as signaling molecules in physiological conditions, and that some of their key targets are cysteine residues on cell cycle",{"id":185,"funder":7,"programme":8,"title":186,"piName":10,"institution":187,"country":158,"year":13,"amount":188,"abstract":189},"cordis-european-research-council-award-677713","Cellular Dynamics of Intestinal Antibody-Mediated Immune Response","WEIZMANN INSTITUTE OF SCIENCE","€1,375,000","Vaccination is widely used to prevent human diseases by inducing the formation of cellular and antibody-mediated immune responses for induction of long lasting immunological memory. Although most studies focus on immune responses elicited against injected immunizations, the simplest delivery of a vaccine regimen is by oral administration. The cellular and molecular components of the antibody immune response in peripheral lymph nodes in response to immunization are well described, however, much l",{"id":191,"funder":7,"programme":8,"title":192,"piName":10,"institution":193,"country":169,"year":13,"amount":194,"abstract":195},"cordis-european-research-council-award-679403","Vaccine profiling and immunodiagnostic discovery by high-throughput antibody repertoire analysis","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","€1,492,586","Vaccines and immunodiagnostics have been vital for public health and medicine, however a quantitative molecular understanding of vaccine-induced antibody responses is lacking. Antibody research is currently going through a big-data driven revolution, largely due to progress in next-generation sequencing (NGS) and bioinformatic analysis of antibody repertoires. A main advantage of high-throughput antibody repertoire analysis is that it provides a wealth of quantitative information not possible wi",{"id":197,"funder":7,"programme":8,"title":198,"piName":10,"institution":199,"country":138,"year":13,"amount":200,"abstract":201},"cordis-european-research-council-award-678215","Differential Higgs distributions as a unique window to New Physics at the LHC","DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY","€1,317,500","In 2012, the ATLAS and CMS experiments at the Large Hadron Collider at CERN announced a ground-breaking discovery: both experiments observed a new particle. Subsequent measurements confirmed it to be a Higgs boson. In the Standard Model (SM) of particle physics, which describes the known elementary particles and their interactions, as well as in many extensions of the SM, the Higgs boson is fundamentally linked to the question of how elementary particles acquire mass. A thorough program of measu",{"id":203,"funder":7,"programme":8,"title":204,"piName":10,"institution":205,"country":12,"year":13,"amount":42,"abstract":206},"cordis-european-research-council-award-679103","Observation and Modelling of Radiocarbon in Atmospheric Methane for Methane Source Identification","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","Observation and Modelling of Radiocarbon in Atmospheric Methane for Methane Source IdentificationGreenhouse gas emissions are the primary cause of global climate change, and methane (CH4) is the second most important contributor after carbon dioxide (CO2). Major sources of methane are both natural (wetlands) and anthropogenic (agriculture, landfills and fossil fuels). Current efforts to assess the anthropogenic CH4 influence on climate change and the effectiveness of mitigation policies for CH4 ",{"id":208,"funder":7,"programme":8,"title":209,"piName":10,"institution":210,"country":12,"year":13,"amount":211,"abstract":212},"cordis-european-research-council-award-679704","Labour market dynamics and optimal policies","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","€1,049,855","From pension reforms to UI extensions, the optimal tax and program design literature is often ill-equipped to provide clear guidance in policy debates on the reform of social insurance and tax-and-benefit systems. The reason is that this literature is mostly focused on static settings, while these programs are inherently dynamic: they specify a schedule of tax and benefits that is time or state dependent and they affect individuals’ decisions throughout their lifetime. DYNAMICSS will offer a sim",{"id":214,"funder":7,"programme":8,"title":215,"piName":10,"institution":54,"country":48,"year":13,"amount":216,"abstract":217},"cordis-european-research-council-award-679116","Unravelling the Mechanosensitivity of Actin Bundles in Filopodia","€1,499,190","Eukaryotic cells constantly convert signals between biochemical energy and mechanical work to timely accomplish many key functions such as migration, division or development. Filopodia are essential finger-like structures that emerge at the cell front to orient the cell in response to its chemical and mechanical environment. Yet, the molecular interactions that make the filopodia mechanosensitive are not known. To tackle this challenge we propose unique biophysical in vitro and in vivo experimen",{"id":219,"funder":7,"programme":8,"title":220,"piName":10,"institution":210,"country":12,"year":13,"amount":221,"abstract":222},"cordis-european-research-council-award-715467","Addressing Too Big to Fail: Resolution, Organizational Structure, and Funding of Global Banks","€1,489,518","One of the main unresolved challenges of the recent financial crisis is how society should deal with global banks that are “too big to fail.” The collapse of Lehman Brothers vividly demonstrated the costs of the failure of such an institution, with sweeping repercussions for the financial system and the broader economy. Yet, implicit public guarantees that would prevent such failures are equally costly, creating moral hazard in the form of increased risk taking and incentives for financial insti",{"id":224,"funder":7,"programme":8,"title":225,"piName":10,"institution":205,"country":12,"year":13,"amount":226,"abstract":227},"cordis-european-research-council-award-677367","Catalytic C–F Bond Functionalization for the Fixation of Environmentally Persistent Fluorocarbons","€1,496,925","The objective of my project is to develop new methods to transform environmentally persistent hydrofluorocarbons (HFCs) and hydrofluoroolefins (HFOs), into reactive chemical building blocks that can be used in chemical manufacture. My team will achieve this by developing a series of new chemical reactions that transform inert carbon–fluorine bonds in HFCs or HFOs into reactive carbon–boron or carbon–aluminum bonds. My team will show that these reactive species can be used to construct carbon–car",{"id":229,"funder":7,"programme":8,"title":230,"piName":10,"institution":205,"country":12,"year":13,"amount":231,"abstract":232},"cordis-european-research-council-award-677854","Hybrid Digital-Analog Networking under Extreme Energy and Latency Constraints","€1,496,350","The objective of the BEACON project is to (re-)introduce analog communications into the design of modern wireless networks. We argue that the extreme energy and latency constraints imposed by the emerging Internet of Everything (IoE) paradigm can only be met within a hybrid digital-analog communications framework. Current network architectures separate source and channel coding, orthogonalize users, and employ long block-length digital source and channel codes, which are either suboptimal or not",{"id":234,"funder":7,"programme":8,"title":235,"piName":10,"institution":236,"country":120,"year":13,"amount":237,"abstract":238},"cordis-european-research-council-award-679145","Astrophysics for the Dark Universe: Cosmological simulations in the context of dark matter and dark energy research","UNIVERSITAT WIEN","€1,471,382","The objective of this ambitious research proposal is to push forward the frontier of computational cosmology by significantly improving the precision of numerical models on par with the increasing richness and depth of surveys that aim to shed light on the nature of dark matter and dark energy.Using new phase-space techniques for the simulation and analysis of dark matter, completely new insights into its dynamics are possible. They allow, for the first time, the accurate simulation of dark matt",{"id":240,"funder":7,"programme":8,"title":241,"piName":10,"institution":54,"country":48,"year":13,"amount":42,"abstract":242},"cordis-european-research-council-award-679408","Relaxation dynamics in closed quantum systems","Statistical mechanics, a century-old theory, is probably one of the most powerful constructions of physics. It predicts that the equilibrium properties of any system composed of a large number of particles depend only on a handful of macroscopic parameters, no matter how the particles interact with each other. But the question of how many-body systems relax towards such equilibrium states remains largely unsolved. This problem is especially acute for quantum systems, which evolve in a much large",{"id":244,"funder":7,"programme":8,"title":245,"piName":10,"institution":54,"country":48,"year":13,"amount":246,"abstract":247},"cordis-european-research-council-award-714291","Physiologically relevant microfluidic neuro-engineering","€1,727,731","Developing minimalistic biological neural networks and observing their functional activity is crucial to decipher the information processing in the brain. This project aims to address two major challenges: to design and fabricate in vitro biological neural networks that are organized in physiological relevant ways and to provide a label-free monitoring platform capable of observing neural activity both at the neuron resolution and at large fields of view. To do so, the project will develop a uni",{"id":249,"funder":7,"programme":8,"title":250,"piName":10,"institution":251,"country":48,"year":13,"amount":10,"abstract":252},"cordis-european-research-council-award-677147","The geometry of modular representations of reductive algebraic groups","UNIVERSITE CLERMONT AUVERGNE","The main theme of this proposal is the Geometric Representation Theory of reductive algebraic groups over algebraically closed fields of positive characteristic. Our primary goal is to obtain character formulas for simple and for indecomposable tilting representations of such groups, by developing a geometric framework for their categories of representations.Obtaining such formulas has been one of the main problems in this area since the 1980's. A program outlined by G. Lusztig in the 1990's has",{"id":254,"funder":7,"programme":8,"title":255,"piName":10,"institution":54,"country":48,"year":13,"amount":256,"abstract":257},"cordis-european-research-council-award-677878","Neuronal Coding of Choice and Action-Selection during Decision-Making in Behaving Mice","€1,499,933","Our daily life is a complex chain of decisions and actions that shapes our behaviors. Individuals tend to choose the best action possible among different alternatives through “goal-directed” decision-making. Given that action-selection is supposed to occur on the basis of the individual subjective evaluation of the relative costs and benefits of each action, two types of information need to be integrated within choice-specific neuronal representations: the causal consequences of an action (outco",{"id":259,"funder":7,"programme":8,"title":260,"piName":10,"institution":54,"country":48,"year":13,"amount":42,"abstract":261},"cordis-european-research-council-award-677470","Structured Ensembles of Atoms for Quantum Engineering of Light","This project aims at building a new versatile platform for quantum engineering of light, with the unique ability to create deterministic coherent photon-photon interactions tunable in range, strength and dimensionality. It will explore a new avenue towards this goal, combining cutting-edge advances of atomic physics with ideas inspired by nanophotonics: a cold micro-structured gas of interacting atoms will act as a Bragg mirror saturable by a single photon, strongly coupling a controlled number ",{"id":263,"funder":7,"programme":8,"title":264,"piName":10,"institution":54,"country":48,"year":13,"amount":265,"abstract":266},"cordis-european-research-council-award-677952","The Tibetan Army of the Dalai Lamas (1642-1959)","€1,499,875","TibArmy proposes to undertake a study of a previously unresearched subject: the Tibetan army during the period of the Buddhist government of the Dalai Lamas, known as the Ganden Phodrang, from 1642 to 1959. This government was the heir to a robust military culture with long experience in the defence of Buddhism since the Tibetan Imperial Period (7th-9th centuries); however, from its inception it decided to rely on foreign armies for its protection. On the basis of two distinctive features of thi",{"id":268,"funder":7,"programme":8,"title":269,"piName":10,"institution":54,"country":48,"year":13,"amount":270,"abstract":271},"cordis-european-research-council-award-680313","The Urban Revolution and the Political","€1,499,940","This project is a transnational and comparative study of the political implications of the contemporary ‘urban revolution,’ namely the sweeping socio-cultural, economic, and territorial transformations through which the urban becomes the predominant mode of existence of societies across the world. Across the social sciences and as well as journalistic literatures, there has been a remarkable proliferation of debates around the social and ecological implications of contemporary urbanization.     ",{"id":273,"funder":7,"programme":8,"title":274,"piName":10,"institution":275,"country":138,"year":13,"amount":276,"abstract":277},"cordis-european-research-council-award-678049","How nature affects cooperation in common pool resource systems","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","€1,413,750","The constraints and dynamics set by nature have a deep and significant impact on economic fundamentals and the ability to successfully manage renewable resources. This can be taken into account to formulate effective policies. However, the causal pathway from the natural to the social environment and its feedback for sustainable resource use is often overlooked, not the least because preferences and incentives are traditionally viewed as being stable and fixed. Yet, it is high time to take this ",{"id":279,"funder":7,"programme":8,"title":280,"piName":10,"institution":281,"country":282,"year":13,"amount":10,"abstract":283},"cordis-european-research-council-award-679362","Prisons: the Rule of Law, Accountability and Rights","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","IE","PRILA will create the first account of how mechanisms for securing rights, ensuring accountability and achieving adherence to the rule of law are experienced in European prisons. Prisons are places where considerable power differentials exist, and are unique sites for the expression of the values which underpin public and prison law. Systems to ensure that prisoners are treated fairly and that rights are upheld are essential to ensure that imprisonment is conducted in ways that are just and prom",{"id":285,"funder":7,"programme":8,"title":286,"piName":10,"institution":281,"country":282,"year":13,"amount":287,"abstract":288},"cordis-european-research-council-award-679173","Targeting iNKT cell and adipocyte crosstalk for control of metabolism and body weight","€1,804,052","Obesity has reached epidemic proportions globally. At least 2.8 million people die each year as a result of being overweight or obese, the biggest burden being obesity-related diseases. It is now clear that inflammation is an underlying cause or contributor to many of these diseases, including type 2 diabetes, atherosclerosis, and cancer. Recognition that the immune system can regulate metabolic pathways has prompted a new way of thinking about diabetes and weight management. Despite much recent",{"id":290,"funder":7,"programme":8,"title":291,"piName":10,"institution":292,"country":80,"year":13,"amount":10,"abstract":293},"cordis-european-research-council-award-675014","Transgenerational regulation of glucose metabolism by noncoding RNAs","SYDDANSK UNIVERSITET","Obesity and T2D affect large populations and cause a decline in life expectancy if untreated. The pandemic proportion of obesity and inaptitude of anti-obesity approaches reflect our limited understanding of its complex environmental and genetic etiology. Genome-wide association studies revealed that disease-associated risk variants are often situated in those 98% of the genome not encoding for proteins. This noncoding genomic space yet does not reflect ‘Junk DNA’ but gives rise to >10,000 nonco",{"id":295,"funder":7,"programme":8,"title":296,"piName":10,"institution":297,"country":12,"year":13,"amount":298,"abstract":299},"cordis-european-research-council-award-679651","Resolving conflicts between food security and biodiversity conservation under uncertainty","THE UNIVERSITY OF STIRLING","€1,497,151","Resolving conflicts between food security and biodiversity conservation under uncertaintyConflicts between food security and biodiversity conservation are increasing in scale and intensity and have been shown to be damaging for both biodiversity and human livelihoods. Uncertainty, for example from climate change, decreases food security, puts further pressure on biodiversity and exacerbates conflicts. I propose to develop a novel model that predicts solutions to conflicts between biodiversity co",{"id":301,"funder":7,"programme":8,"title":302,"piName":10,"institution":119,"country":120,"year":13,"amount":42,"abstract":303},"cordis-european-research-council-award-639270","Symbolic Computation and Automated Reasoning for Program Analysis","Individuals, industries, and nations are depending on software and systems using software. Automated approaches are needed to eliminate tedious aspects of software development, helping software developers in dealing with the increasing software complexity. Automatic program analysis aims to discover program properties preventing programmers from introducing errors while making changes and can drastically cut the time needed for program development.This project addresses the challenge of automati",{"id":305,"funder":7,"programme":8,"title":306,"piName":10,"institution":307,"country":138,"year":13,"amount":308,"abstract":309},"cordis-european-research-council-award-715271","From fast food to healthy diet: Addressing the dynamic molecular mechanism of sequential diet switch-induced T cell plasticity for the purpose of developing new treatments for immuno-mediated diseases","UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF","€1,499,695","The incidence of chronic immune-mediated inflammatory diseases is continually increasing. Chronic inflammation has been linked to intestinal carcinogenesis, which is the second leading cause of cancer-related deaths. The cause of this increase could be the unprecedented dietary abundance typical of “Western” countries. Different types of diets shape the genetic composition and metabolic activity of human intestinal microorganisms",{"id":311,"funder":7,"programme":8,"title":312,"piName":10,"institution":313,"country":120,"year":13,"amount":314,"abstract":315},"cordis-european-research-council-award-677006","Crosstalk of Metabolism and Inflammation","CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH","€1,701,011","Inflammation is a response to noxious stimuli and initiates tissue repair. If resolution fails, however, chronic inflammation develops, which drives tissue damage in many diseases including autoimmunity, cancer and infections. Inflammatory processes are increasingly being appreciated as tightly integrated with metabolic pathways. The molecular crosstalk occurs on different levels including secreted metabolites and cytokines. I hypothesise that this interface of metabolism and inflammation repres",{"id":317,"funder":7,"programme":8,"title":318,"piName":10,"institution":319,"country":113,"year":13,"amount":320,"abstract":321},"cordis-european-research-council-award-679812","CLIMATE ADAPTATION TO SHIFTING STOCKS","UNIVERSIDAD DE VIGO","€1,184,931","Management of marine fisheries is still far from incorporating adaptation to climate change, even though global stocks are heavily overexploited and climate change is adding additional pressure to the resource.  In fact, there is growing evidence that current fisheries management systems may no longer be effective under climate change, and this will translate into both ecological and socioeconomic impacts. This research project argues that the combination of fisheries management science and soci",{"id":323,"funder":7,"programme":8,"title":324,"piName":10,"institution":325,"country":145,"year":13,"amount":326,"abstract":327},"cordis-european-research-council-award-679242","Integrative omics of heart failure to inform discovery of novel drug targets and clinical biomarkers","LUNDS UNIVERSITET","€1,496,625","Heart failure is a leading cause of morbidity and mortality in the aging European populations. It is the end-stage of myocardial and valvular disease, arising from loss of viable or functional muscle cells in the heart. Therapy is complicated by the multitude of causes and comorbidities of heart failure. New therapeutic targets and clinical biomarkers to individually tailor therapy (‘precision medicine’) are greatly needed. This research program aims to realize the promise of precision medicine ",{"id":329,"funder":7,"programme":8,"title":330,"piName":10,"institution":331,"country":48,"year":13,"amount":42,"abstract":332},"cordis-european-research-council-award-717034","Resistance mechanisms to tyrosine kinase inhibitors in solid tumors","INSTITUT GUSTAVE ROUSSY","Over the past 10 years, the chemotherapeutic arsenal has been expanded to include molecular-targeted therapies based on the principle that cancer cells become addicted to a single driver oncogene. However, use of these new therapies is limited due to development of acquired resistance. To fully understand how resistance develops, patient-derived models are an absolute pre-requisite, but establishing them remains extremely challenging. Few groups worldwide have successfully implemented a systemat",{"id":334,"funder":7,"programme":8,"title":335,"piName":10,"institution":336,"country":48,"year":13,"amount":42,"abstract":337},"cordis-european-research-council-award-678624","Understanding and manipulating the dynamics of chromosome topologies in transcriptional control","CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET EN MEDECINE","Transcriptional regulation of genes in eukaryotic cells requires a complex and highly regulated interplay of chromatin environment, epigenetic status of target sequences and several different transcription factors. Eukaryotic genomes are tightly packaged within nuclei, yet must be accessible for transcription, replication and repair. A striking correlation exists between chromatin topology and underlying gene activity. According to the textbook view, chromatin loops bring genes into direct conta",{"id":339,"funder":7,"programme":8,"title":340,"piName":10,"institution":341,"country":41,"year":13,"amount":342,"abstract":343},"cordis-european-research-council-award-680220","Quantification and modality in the realm of questions","UNIVERSITEIT VAN AMSTERDAM","€1,391,324","The interpretation of linguistic expressions has been investigated from various theoretical perspectives, ranging from linguistics and philosophy to logic and cognitive science, leading to many applications in computer science. At the heart of this enterprise is a simple yet powerful notion of meaning as truth-conditional content. Despite its merits, this view has a fundamental limitation: while suitable for statements, it does not apply to other sentence types, like questions.This limitation ha",{"id":345,"funder":7,"programme":8,"title":346,"piName":10,"institution":347,"country":158,"year":13,"amount":42,"abstract":348},"cordis-european-research-council-award-676844","Do behaving animals extract information from precise spike timing? – The use of temporal codes","TEL AVIV UNIVERSITY","Neural temporal codes have come to dominate our way of thinking on how information is coded in the brain. When precise spike timing is found to carry information, the neural code is defined as a temporal code. In spite of the importance of temporal codes, whether behaving animals actually use this type of coding is still an unresolved question. To date studying temporal codes was technically impossible due to the inability to manipulate spike timing in behaving animals. However, very recent deve",{"id":350,"funder":7,"programme":8,"title":351,"piName":10,"institution":352,"country":80,"year":13,"amount":10,"abstract":353},"cordis-european-research-council-award-679754","Dissecting the constraints that define the eukaryotic DNA replication program","KOBENHAVNS UNIVERSITET","DNA replication is essential for the perpetuation of life and, yet, it is also a major source of genomic instability that can lead to cancer and other human diseases. Despite the vast efforts invested in establishing the origins of genomic instability, the mechanisms that coordinate faithful genome duplication while ensuring its integrity remain unknown.This dilemma is molecularly best exemplified by single stranded DNA (ssDNA), which inevitably results from unwinding the double helix due to rep",{"id":355,"funder":7,"programme":8,"title":356,"piName":10,"institution":357,"country":138,"year":13,"amount":265,"abstract":358},"cordis-european-research-council-award-677650","Analysis and Representation of Complex Activities in Videos","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","The goal of the project is to automatically analyse human activities observed in videos. Any solution to this problem will allow the development of novel applications. It could be used to create short videos that summarize daily activities to support patients suffering from Alzheimer's disease. It could also be used for education, e.g., by providing a video analysis for a trainee in the hospital that shows if the tasks have been correctly executed.The analysis of complex activities in videos, ho",{"id":360,"funder":7,"programme":8,"title":361,"piName":10,"institution":362,"country":363,"year":13,"amount":364,"abstract":365},"cordis-european-research-council-award-677502","Lordship and the Rise of States in Western Europe, 1300-1600","UNIVERSITEIT GENT","BE","€1,496,875","This project pursues a new interpretation of state formation in Western Europe between 1300 and 1600. This period is considered as the key phase in the genesis of the modern state, as various polities now centralized fiscal and military resources under their command. While there is debate whether this was primarily a top-down process carried by princes, or a bottom-up process carried by popular representation, scholars agree that state building was exclusively a process of centralization. This a",{"id":367,"funder":7,"programme":8,"title":368,"piName":10,"institution":369,"country":41,"year":13,"amount":42,"abstract":370},"cordis-european-research-council-award-680235","Cerebellar modules and the Ontogeny of Sensorimotor Integration","ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM","The perfect execution of a voluntary movement requires the appropriate integration of current bodily state, sensory input and desired outcome. To assure that this motor output becomes and remains appropriate, the brain needs to learn from the result of previous outputs. The cerebellum plays a central role in sensorimotor integration, yet -despite decades of studies- there is no generally excepted theory for cerebellar functioning. I recently demonstrated that cerebellar modules, identified based",{"id":372,"funder":7,"programme":8,"title":373,"piName":10,"institution":325,"country":145,"year":13,"amount":374,"abstract":375},"cordis-european-research-council-award-678698","Mathematical aspects of three-dimensional water waves with vorticity","€1,203,627","The goal of this project is to develop a mathematical theory for steady three-dimensional water waves with vorticity. The mathematical model consists of the incompressible Euler equations with a free surface, and vorticity is important for modelling the interaction of surface waves with non-uniform currents. In the two-dimensional case, there has been a lot of progress on water waves with vorticity in the last decade. This progress has mainly been based on the stream function formulation, in whi",{"id":377,"funder":7,"programme":8,"title":378,"piName":10,"institution":379,"country":138,"year":13,"amount":380,"abstract":381},"cordis-european-research-council-award-680241","From Tissues to Single Molecules: High Content in Situ Super-Resolution imaging with DNA-PAINT","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€1,695,000","Fluorescence microscopy is a powerful tool for exploring biomolecules in cells and tissues, especially with the advent of super-resolution techniques. To better understand key processes such as cell differentiation and disease progression, it is crucial to investigate the abundance, localization and mutual interactions of crucial cellular components such as nucleic acids and proteins. Unraveling their complex interplay in whole signaling networks is necessary to investigate cellular responses to",{"id":383,"funder":7,"programme":8,"title":384,"piName":10,"institution":385,"country":41,"year":13,"amount":386,"abstract":387},"cordis-european-research-council-award-676842","Strong single-photon radiation-pressure coupling for quantum optomechanics","TECHNISCHE UNIVERSITEIT DELFT","€1,499,970","While quantum physics is one of the most successful theories in modern science, it remains a puzzle why we do not observe quantum effects in our macroscopic every-day life. Quantum theory in fact does not pose an inherent limit on the size and mass of a quantum system. The field of optomechanics has been established with the explicit goal of testing massive, macroscopic quantum states. Here, the radiation-pressure force is used to bring a mechanical oscillator into a quantum state by coupling it",{"id":389,"funder":7,"programme":8,"title":390,"piName":10,"institution":385,"country":41,"year":13,"amount":391,"abstract":392},"cordis-european-research-council-award-679924","Quantum communication networks","€1,498,725","My goal is to overcome the two-most pressing theoretical challenges necessary to build large-scale quantum communication networks: routing and designing protocols that use them to solve useful tasks. In two interconnected projects, I will devise entirely new concepts, models and mathematical methods that take into account the intricacies of real world quantum devices that can operate on only very few quantum bits at a time.(1) Security: I will prove the security of quantum cryptographic protocol",{"id":394,"funder":7,"programme":8,"title":395,"piName":10,"institution":385,"country":41,"year":13,"amount":396,"abstract":397},"cordis-european-research-council-award-677575","Meta-biomaterials: 3D printing meets Origami","€1,499,600","Meta-materials, best known for their extraordinary properties (e.g. negative stiffness), are halfway from both materials and structures: their unusual properties are direct results of their complex 3D structures. This project introduces a new class of meta-materials called meta-biomaterials. Meta-biomaterials go beyond meta-materials by adding an extra dimension to the complex 3D structure, i.e. complex and precisely controlled surface nano-patterns. The 3D structure gives rise to unprecedented ",{"id":399,"funder":7,"programme":8,"title":400,"piName":10,"institution":385,"country":41,"year":13,"amount":401,"abstract":402},"cordis-european-research-council-award-677458","Designer Quantum Materials Out of Equilibrium","€1,499,982","Recently, ‘designer’ quantum materials, synthesised layer by layer, have been realised, sparking ground-breaking new scientific insights. These artificial materials, such as oxide heterostructures, are interesting building blocks for a new generation of technologies, provided that one is able to access, study and ultimately control their quantum phases in practical conditions such as at room temperature and high speeds.On the other hand, an independent research area is emerging that uses ultra-s",{"id":404,"funder":7,"programme":8,"title":405,"piName":10,"institution":385,"country":41,"year":13,"amount":406,"abstract":407},"cordis-european-research-council-award-676895","Spin correlations by atomic design","€1,449,983","Unexpected physical phenomena occurring in materials often result from the complex interplay between spins on the atomic scale. The field of quantum magnetism aims to capture the rich emergent physics that arises when multiple spins interact. While experimental techniques are available to probe the global quantum magnetic properties of materials, they fail to reveal the role of local features such as individual defects or phase boundaries. I propose to use custom-designed spin lattices created b",{"id":409,"funder":7,"programme":8,"title":410,"piName":10,"institution":385,"country":41,"year":13,"amount":411,"abstract":412},"cordis-european-research-council-award-677312","Urban modelling in higher dimensions: embedding generalisation of 3D data in a 4D model","€1,498,148","Geographic data about urban objects (buildings, roads) is needed to monitor and control processes within modern urban areas (noise, flooding, energy demand-supply). As these processes occur in 3D, urban applications require 3D data and each application requires its own specific semantic and geometric Level of Detail (LoD) of the 3D data.The scientific challenge of this project is that it requires enormous efforts to collect and transform 3D data to make it suitable for a specific application. Ur",{"id":414,"funder":7,"programme":8,"title":415,"piName":10,"institution":385,"country":41,"year":13,"amount":416,"abstract":417},"cordis-european-research-council-award-678145","Coupled climate and Greenland ice sheet evolution:past, present and future","€1,677,282","The Greenland ice sheet (GrIS) is losing mass at an increasing pace, in response to atmospheric and ocean forcing. The mechanisms leading to the observed mass loss are poorly understood. It is not clear whether the current trends will be sustained into the future, and how they are affected by regional and global climate variability. In addition, the impacts of Greenland deglaciation on the local and global climate are not well known. This project aims to explain the relationship between GrIS sur",{"id":419,"funder":7,"programme":8,"title":420,"piName":10,"institution":385,"country":41,"year":13,"amount":421,"abstract":422},"cordis-european-research-council-award-678004","Doping on Demand: precise and permanent control of the Fermi level in nanocrystal assemblies","€1,497,842","The aim of the work proposed here is to develop a completely new method to electronically dope assemblies of semiconductor nanocrystals (a.k.a quantum dots, QDs), and porous semiconductors in general. External dopants are added on demand in the form of electrolyte ions in the voids between QDs. These ions will be introduced via electrochemical charge injection, and will subsequently be immobilized by (1) freezing the electrolyte solvent at room temperature or (2) chemically linking the ions to l",{"id":424,"funder":7,"programme":8,"title":425,"piName":10,"institution":426,"country":282,"year":13,"amount":427,"abstract":428},"cordis-european-research-council-award-637691","Animal coloration through deep time: evolutionary novelty, homology and taphonomy","UNIVERSITY COLLEGE CORK -  NATIONAL UNIVERSITY OF IRELAND, CORK","€1,562,000","What does the fossil record tell us about the evolution of colour in animals through deep time? Evidence of colour in fossils can inform on the visual signalling strategies used by ancient animals. Research to date often has a narrow focus, lacks a broad phylogenetic and temporal context, and rarely incorporates information on taphonomy. This proposal represents a bold new holistic approach to the study of fossil colour: it will couple powerful imaging- and chemical analytical techniques with a ",{"id":430,"funder":7,"programme":8,"title":431,"piName":10,"institution":426,"country":282,"year":13,"amount":432,"abstract":433},"cordis-european-research-council-award-677355","Creative Agency and Religious Minorities: ‘hidden galleries’ in the secret police archives in 20th Century Central and Eastern Europe","€990,087","This project concerns the creative agency of religious minorities in the transformation of Central and Eastern Europe societies in the 20th century. It constitutes the first comparative research on the secret police archives in the region from the perspective of the history and anthropology of religion and offers a radical perspectival shift on the value and uses of the secret police archives away from questions of justice and truth to questions of creative agency and cultural patrimony. Interdi",{"id":435,"funder":7,"programme":8,"title":436,"piName":10,"institution":437,"country":48,"year":13,"amount":42,"abstract":438},"cordis-european-research-council-award-679937","Interpreting Dust Polarization Maps to Characterize the Role of the Magnetic Field in Star Formation Processes","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","Rotation and angular momentum transport play a critical role in the formation and evolution of astrophysical objects, including the fundamental bricks of astrophysical structures: stars. Stars like our Sun form when rotating dense cores, in the interstellar medium, collapse until they eventually reach temperatures at which nuclear fusion begins",{"id":440,"funder":7,"programme":8,"title":441,"piName":10,"institution":437,"country":48,"year":13,"amount":42,"abstract":442},"cordis-european-research-council-award-679531","Electron quantum optics in Graphene","Quantum computing is based on the manipulation of quantum bits (qubits) to enhance the efficiency of information processing. In solid-state systems, two approaches have been explored: • static qubits, coupled to quantum buses used for manipulation and information transmission,• flying qubits which are mobile qubits propagating in quantum circuits for further manipulation. Flying qubits research led to the recent emergence of the field of electron quantum optics, where electrons play the role of ",{"id":444,"funder":7,"programme":8,"title":445,"piName":10,"institution":437,"country":48,"year":13,"amount":446,"abstract":447},"cordis-european-research-council-award-678282","non-LinEar sigNal processing for solving data challenges in Astrophysics","€1,497,411","Astrophysics has arrived to a turning point where the scientific exploitation of data requires overcoming challenging analysis issues, which mandates the development of advanced signal processing methods. In this context, sparsity and sparse signal representations have played a prominent role in astrophysics. Indeed, thanks to sparsity, an extremely clean full-sky map of the Cosmic Microwave Background (CMB) has been derived from the Planck data [Bobin14], a European space mission that observes ",{"id":449,"funder":7,"programme":8,"title":450,"piName":10,"institution":451,"country":363,"year":13,"amount":42,"abstract":452},"cordis-european-research-council-award-677169","Controlled synthesis of particulate matter in microfluidics","KATHOLIEKE UNIVERSITEIT LEUVEN","Despite the many advantages of microchemical systems and their successful applications in chemicalengineering research, one major drawback greatly limiting their use is their susceptibility to channel cloggingfor flows containing particulate matter. Hence, the aim of the proposed research is to overcome the challengeof clogging in microfluidic devices and to design microfluidic systems that can tolerate particulate matterand synthesize solid materials according to their specifications (e.g. size",{"id":454,"funder":7,"programme":8,"title":455,"piName":10,"institution":456,"country":158,"year":13,"amount":457,"abstract":458},"cordis-european-research-council-award-678734","Dynamic Microfluidic Structures for Analysis of Single Cell Systems","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","€1,744,056","The interaction and communication between individual cells plays a central role in virtually all fields of biology, from the cooperative work of cells in the immune system, through the differentiation of stem cells, and to the proliferation of cancer cells. In recent years it has been shown that these processes are fundamentally coupled to cell-to-cell heterogeneity and variability. Despite the fact that studying cellular ensembles obscures these fundamental biological processes, most current st",{"id":460,"funder":7,"programme":8,"title":461,"piName":10,"institution":456,"country":158,"year":13,"amount":462,"abstract":463},"cordis-european-research-council-award-680242","Next-Generation Personalized Diagnostic Nanotechnologies for Predicting Response to Cancer Medicine","€1,499,250","Cancer is the leading cause of death in the Western world and the second cause of death worldwide. Despite advances in medical research, 30% of cancer patients are prescribed a medication the tumor does not respond to, or, alternatively, drugs that induce adverse side effects patients' cannot tolerate.Nanotechnologies are becoming impactful therapeutic tools, granting tissue-targeting and cellular precision that cannot be attained using systems of larger scale.In this proposal, I plan to expand ",{"id":465,"funder":7,"programme":8,"title":466,"piName":10,"institution":467,"country":169,"year":13,"amount":468,"abstract":469},"cordis-european-research-council-award-678834","Holding hands: cell-cell junctions in breast cancer metastasis and resistance to therapy","UNIVERSITAT BASEL","€1,744,921","Breast cancer is the most common cancer in women, resulting in as many as 500000 deaths per year worldwide. Patients with breast cancer die unequivocally because of the development of incurable distant metastases and not because of symptoms related to the primary site. Understanding the complex, yet fundamental mechanisms driving breast cancer metastasis is critical to develop therapies tailored to this disease. The current understanding of how metastasis occurs is derived primarily from mouse m",{"id":471,"funder":7,"programme":8,"title":472,"piName":10,"institution":473,"country":12,"year":13,"amount":474,"abstract":475},"cordis-european-research-council-award-677270","Mechanisms and Consequences of Attributing Socialness to Artificial Agents","UNIVERSITY OF GLASGOW","€1,809,000","Understanding how we perceive and interact with others is a core challenge of social cognition research. This challenge is poised to intensify in importance as the ubiquity of artificial intelligence and the presence of humanoid robots in society grows. By innovatively combining psychology, neuroscience and robotics, the SOCIAL ROBOTS project helps prepare us for this future by (1) establishing a new approach for understanding how the human brain processes and responds to interactive robots; (2)",{"id":477,"funder":7,"programme":8,"title":478,"piName":10,"institution":193,"country":169,"year":13,"amount":479,"abstract":480},"cordis-european-research-council-award-678841","Novel interactions and species’ responses to climate change","€1,499,534","A great ecological challenges is predicting the responses of species, communities and ecosystems to global climate change. Progress will hinge on our ability to predict how responses are shaped by evolution and species interactions, and especially by entirely novel interactions among species whose ranges don't yet overlap. To tackle this goal, I will combine cutting-edge experiments and process-based modeling to address three questions about the impact of novel competitors on responses to climat",{"id":482,"funder":7,"programme":8,"title":483,"piName":10,"institution":187,"country":158,"year":13,"amount":42,"abstract":484},"cordis-european-research-council-award-678674","Quantum fluids of photons in optically-induced structures","A variety of classical optical systems exhibiting rich and complex matter-like behavior have been explored in recent years. Unfortunately in the optical regime, photons – the fundamental constituents of light – do not interact strongly with one another, and therefore cannot be used for studying many-body effects. It is only in the extreme regime of quantum nonlinear optics where effective interactions between photons are made strong. In an atomic gas, strong long-range interactions can be achiev",{"id":486,"funder":7,"programme":8,"title":487,"piName":10,"institution":488,"country":138,"year":13,"amount":489,"abstract":490},"cordis-european-research-council-award-679852","The radiative interstellar medium","UNIVERSITAT ZU KOLN","€1,488,048","The pressure, radiation, and ionization from the warm (UV emitting) and hot (X-ray emitting) gas has a significant impact on the cold, star-forming interstellar medium. We propose to carry out a comprehensive 3D study of the turbulent, multi-phase ISM in different environments that includes, for the first time, a proper treatment of UV and X-ray emission from stellar (primary) sources and extended (secondary) sources like cooling shock fronts and evaporating clouds. We do this by means of massiv",{"id":492,"funder":7,"programme":8,"title":493,"piName":10,"institution":494,"country":12,"year":13,"amount":495,"abstract":496},"cordis-european-research-council-award-679873","MONSOON ASSEMBLAGES","THE UNIVERSITY OF WESTMINSTER LBG","€1,497,212","The ambition of this cutting edge research project is to deliver a ground breaking, interdisciplinary design-driven inquiry into the impacts of changing monsoon climates in four of South Asia’s rapidly growing cities. This will be undertaken at a time when climate change and urban development conspire to produce unlikely futures for urban survival. Extreme weather events, all attributed to the monsoon’s capricious nature, are resulting in increasing frequency in water shortages, power failures, ",{"id":498,"funder":7,"programme":8,"title":499,"piName":10,"institution":500,"country":501,"year":13,"amount":502,"abstract":503},"cordis-european-research-council-award-680263","Novel 2D quantum device concepts enabled by sub-nanometre precision nanofabrication","HUN-REN ENERGIATUDOMANYI KUTATOKOZPONT","HU","€1,496,500","IIn today’s electronics, the information storage and processing are performed by independent technologies. The information-processing is based on semiconductor (silicon) devices, while non-volatile data storage relies on ferromagnetic metals. Integrating these tasks on a single chip and within the same material technology would enable disruptively new device concepts opening the way towards ultra-high speed electronic circuits. Due to the unique versatility of its electronic and magnetic propert",{"id":505,"funder":7,"programme":8,"title":506,"piName":10,"institution":507,"country":113,"year":13,"amount":508,"abstract":509},"cordis-european-research-council-award-714577","Frontiers in Phononics: Parity-Time Symmetric Phononic Metamaterials","UNIVERSIDAD CARLOS III DE MADRID","€1,325,158","The boost experienced by acoustic and elastic (phononic) metamaterial research during the past years has been driven by the ability to sculpture the flow of sound waves at will. Thanks to recent developments at the frontiers of phononic metamaterials it can be identified that active phononic control is at the cutting edge of the current research on phononic metamaterials. Introducing piezoelectric semiconductors as a material platform to discover new avenues in wave physics will have the potenti",{"id":511,"funder":7,"programme":8,"title":512,"piName":10,"institution":513,"country":151,"year":13,"amount":42,"abstract":514},"cordis-european-research-council-award-679627","Galaxy evolution in dense environments","ISTITUTO NAZIONALE DI ASTROFISICA","The Universe around us is populated with galaxies, each containing from millions to tens of billions of individual stars. Far from being immutable, galaxies undergo profound changes as they age. Their evolution depends on their position in the cosmic web, a network of sheets and filaments of matter that stretches across the entire Universe. The goal of FORNAX is to study the evolution of galaxies in the densest regions of the cosmic web, galaxy clusters. In these regions, a number of physical pr",{"id":516,"funder":7,"programme":8,"title":517,"piName":10,"institution":518,"country":48,"year":13,"amount":519,"abstract":520},"cordis-european-research-council-award-677368","Quantum Algebraic Structures In Field Theories","INSTITUT DES HAUTES ETUDES SCIENTIFIQUES","€1,498,750","Quantum Field Theory is a universal framework to address quantum physical systems with infinitely many interacting degrees of freedom, applicable both at the level of fundamental interactions, such as the subnuclear physics of quarks and gluons and at the phenomenological level such as the physics of quantum fluids and superconductivity.    Traditionally, weakly interacting quantum field theory is formulated as a perturbative deformation of the linear theory of freely propagating quantum waves o",{"id":522,"funder":7,"programme":8,"title":523,"piName":10,"institution":524,"country":525,"year":13,"amount":526,"abstract":527},"cordis-european-research-council-award-677465","Smart Biologics: Developing New Tools in Glycobiology","USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I.","CZ","€1,405,625","Glycans are ubiquitous biomolecules found throughout all kingdoms of life. Early studies contributed considerably to our appreciation of glycan functions by showing that abnormalities in the glycosylation can develop into pathogenesis and severe dysfunctions. Despite the crucial role of sugars in many biological events we still do not have adequate tools to decipher their complexity. To unveil the mysteries in the rapidly emerging field of glycobiology we aim in this proposal to develop new tool",{"id":529,"funder":7,"programme":8,"title":530,"piName":10,"institution":347,"country":158,"year":13,"amount":531,"abstract":532},"cordis-european-research-council-award-716220","Selective glycoimmuno-targeting for cancer therapy","€1,479,995","Immunotherapy recently became an important alternative to conventional treatment regimes, yet cancer remains a universal leading cause of death. Thus, novel cancer theranostic approaches are still much desired. Although altered cell surface glycosylation is one of the hallmarks of cancer, targeting this ‘sweet aim’ for cancer therapy has been elusive, largely due to carbohydrates poor immunogenicity and the low affinity of antibodies against them. A red meat-derived carbohydrate antigen is a nov",{"id":534,"funder":7,"programme":8,"title":535,"piName":10,"institution":536,"country":12,"year":13,"amount":537,"abstract":538},"cordis-european-research-council-award-679990","Establishing genetic code expansion as a tool to study neuronal circuit function in an animal","THE UNIVERSITY OF EDINBURGH","€1,499,520","We pioneered technologies that allow the site-specific introduction of chemically synthesized unnatural amino acids (UAA) into a chosen protein within the context of a multicellular organism - the nematode worm C. elegans. The foundational technology for this advance is genetic code expansion.In its most simple form, genetic code expansion to incorporate UAA into proteins requires an orthogonal aminoacyl-tRNA synthetase\u002FtRNACUA pair to be introduced into the host organism. The orthogonal aminoac",{"id":540,"funder":7,"programme":8,"title":541,"piName":10,"institution":542,"country":138,"year":13,"amount":543,"abstract":544},"cordis-european-research-council-award-677673","Integration of herpesvirus into telomeres: From the mechanism of genome integration and mobilization to therapeutic intervention","FREIE UNIVERSITAET BERLIN","€1,810,747","Herpesviruses cause serious diseases in humans and animals. After initial lytic infection, herpesviruses establish a quiescent (latent) infection, which allows their persistence in the host for life. We and others recently identified a novel mechanism that allows maintenance of the genome of certain herpesviruses during latency, by integrating their complete genetic material into host telomeres. One of these viruses is human herpesvirus 6 (HHV-6) which is associated with seizures, encephalitis, ",{"id":546,"funder":7,"programme":8,"title":547,"piName":10,"institution":548,"country":549,"year":13,"amount":550,"abstract":551},"cordis-european-research-council-award-679058","Sensing activity-induced cell swellings and ensuing neurotransmitter releases for in-vivo functional imaging sans hemodynamics","FUNDACAO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD","PT","€1,787,500","Functional-Magnetic Resonance Imaging (fMRI) has transformed our understanding of brain function due to its ability to noninvasively tag ‘active’ brain regions. Nevertheless, fMRI only detects neural activity indirectly, by relying on slow hemodynamic couplings whose relationships with underlying neural activity are not fully known. We have recently pioneered two unique MR approaches: Non-Uniform Oscillating-Gradient Spin-Echo (NOGSE) MRI and Relaxation Enhanced MR Spectroscopy (RE MRS). NOGSE-M",{"id":553,"funder":7,"programme":8,"title":554,"piName":10,"institution":555,"country":549,"year":13,"amount":556,"abstract":557},"cordis-european-research-council-award-680156","The Pancreas Regulome: From causality to prediction of non-coding mutations in human pancreatic diseases","INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC","€1,497,520","Several human pancreatic diseases have been characterized, being the diabetes the most common. Like others, this genetic disease is related to disrupted non-coding cis-regulatory elements (CREs) that culminate in altered gene expression. Although Genome Wide Association Studies support this hypothesis, it’s still unclear how mutations on CREs contribute to disease. The translation from the “non-coding code” to phenotype is an exciting and unexplored field that we will approach in this project wi",{"id":559,"funder":7,"programme":8,"title":560,"piName":10,"institution":561,"country":113,"year":13,"amount":562,"abstract":563},"cordis-european-research-council-award-680004","Women travelling to seek abortion care in Europe: the impact of barriers to legal abortion on women living in countries with ostensibly liberal abortion laws","UNIVERSITAT DE BARCELONA","€1,495,753","In many European countries with ostensibly liberal abortion laws, women face legal restrictions to abortion beyond the first trimester of pregnancy, as well as other barriers to legal abortion, in particular shortages of providers willing and able to offer abortion due to poor training and to conscientious objection among physicians. The Council of Europe has recognized that conscientious objection can make access to safe abortion more difficult or impossible, particularly in rural areas and for",{"id":565,"funder":7,"programme":8,"title":566,"piName":10,"institution":567,"country":41,"year":13,"amount":42,"abstract":568},"cordis-european-research-council-award-677500","Molecular Adhesion and Interactions in the Nervous system","UNIVERSITEIT UTRECHT","Surface-attached proteins establish cell-to-cell contacts and generate signals to control development and function of tissues. It is not clear how protein structure and interactions organize into intercellular assemblies to regulate signalling and adhesion. Using a hybrid approach and focusing on two cell-signalling systems critical for nervous system function, I will determine how protein conformation, interaction and spatial arrangement form cis and trans assemblies to control intercellular ad",{"id":570,"funder":7,"programme":8,"title":571,"piName":10,"institution":467,"country":169,"year":13,"amount":572,"abstract":573},"cordis-european-research-council-award-677548","Modular mechanical-atomic quantum systems","€1,498,961","Atomic ensembles are routinely prepared and manipulated in the quantum regime using the powerful techniques of laser cooling and trapping. To achieve similar control over the vibrations of nanofabricated mechanical oscillators is a goal that is vigorously pursued, which recently led to the first observations of ground-state cooling and quantum behavior in such systems.In this project, we will explore the new conceptual and experimental possibilities offered by hybrid systems in which the vibrati",{"id":575,"funder":7,"programme":8,"title":576,"piName":10,"institution":577,"country":138,"year":13,"amount":10,"abstract":578},"cordis-european-research-council-award-677742","Focus alternatives in the human mind: Retrieval, representation, and recall","HUMBOLDT-UNIVERSITAET ZU BERLIN","The sentences: “I have written a proposal for the ERC” and “It is for the ERC that I have written a proposal” mean the same, but they have a different focus structure. A focused element like “It is for the ERC” indicates that alternatives are relevant for the interpretation of the utterance. Hence, the sentence expresses, in addition to its literal content, that the proposal is not for the NSF or the German Research Foundation. The alternative set is a theoretical construct from formal semantics",{"id":580,"funder":7,"programme":8,"title":581,"piName":10,"institution":582,"country":363,"year":13,"amount":583,"abstract":584},"cordis-european-research-council-award-679841","Order in one dimension: Functional hybrids of chirality-sorted carbon nanotubes","UNIVERSITEIT ANTWERPEN","€1,499,425","The hollow structure of carbon nanotubes (CNTs) with a wide range of diameters forms an ideal one-dimensional host system to study restricted diameter-dependent molecular transport and to achieve unique polar molecular order. For the ORDERin1D project, I will capitalize on my recent breakthroughs in the processing, filling, chiral sorting and high-resolution spectroscopic characterization of empty and filled CNTs, aiming for a diameter-dependent characterization of the filling with various molec",{"id":586,"funder":7,"programme":8,"title":587,"piName":10,"institution":588,"country":158,"year":13,"amount":589,"abstract":590},"cordis-european-research-council-award-679228","Light and sound waves in silicon and nonlinear glass waveguides","BAR ILAN UNIVERSITY","€1,496,944","The interplay of light and sound waves in matter has attracted the attention of researchers for decades and has found many technological applications. Photonic integrated circuits (PICs) provide an exciting playground for such investigations, due to wavelength-scale guiding structures, periodicity in one or two dimensions, and high-quality resonance structures. The objectives of this proposal are to introduce, investigate and employ interactions between guided optical modes and hyper-sonic acous",{"id":592,"funder":7,"programme":8,"title":593,"piName":10,"institution":594,"country":158,"year":13,"amount":595,"abstract":596},"cordis-european-research-council-award-678461","Unravelling the role of lysine acetylation in the regulation of glycolysis in cancer cells through the development of synthetic biology-based tools","BEN-GURION UNIVERSITY OF THE NEGEV","€1,499,375","Synthetic biology is an emerging discipline that offers powerful tools to control and manipulate fundamental processes in living matter. We propose to develop and apply such tools to modify the genetic code of cultured mammalian cells and bacteria with the aim to study the role of lysine acetylation in the regulation of metabolism and in cancer development. Thousands of lysine acetylation sites were recently discovered on non-histone proteins, suggesting that acetylation is a widespread and evol",{"id":598,"funder":7,"programme":8,"title":599,"piName":10,"institution":600,"country":169,"year":13,"amount":601,"abstract":602},"cordis-european-research-council-award-677875","Longing for a good night's sleep: A memory-based mechanism to improve sleep and cognitive functioning.","UNIVERSITE DE FRIBOURG","€1,499,565","Sleep is critical for optimal cognitive functioning and health. Sleep disturbances are highly frequent in our society and strongly influenced by cognitive factors, e.g. rumination, expectations and thoughts. However, the mechanism of how cognition influences sleep architecture is not yet understood. To explain how cognition influences sleep, I propose the “Memories-of-Sleep” (MemoSleep)-Hypothesis. Based on the theory of embodied cognition and evidence that memories are reactivated during sleep,",{"id":604,"funder":7,"programme":8,"title":605,"piName":10,"institution":325,"country":145,"year":13,"amount":606,"abstract":607},"cordis-european-research-council-award-679305","Discovery strategies for Dark Matter and new phenomena in hadronic signatures with the ATLAS detector at the Large Hadron Collider","€1,268,076","The Standard Model of Particle Physics describes the fundamental components of ordinary matter and their interactions. Despite its success in predicting many experimental results,  the Standard Model fails to account for a number of interesting phenomena. One phenomenon of particular interest is the large excess of unobservable (Dark) matter in the Universe. This excess cannot be explained by Standard Model particles. A compelling hypothesis is that Dark Matter is comprised of particles that can",{"id":609,"funder":7,"programme":8,"title":610,"piName":10,"institution":611,"country":48,"year":13,"amount":612,"abstract":613},"cordis-european-research-council-award-714693","Robust Mechanism Design and Robust Prediction in Games","FONDATION JEAN JACQUES LAFFONT,TOULOUSE SCIENCES ECONOMIQUES","€1,295,062","In the last several decades, it has been extensively studied how strategic behavior of economic agents could affect the outcomes of various institutions. Game theory and mechanism design theory play key roles in understanding economic agents' possible behavior in those institutions, its welfare consequences, and how we should design economic institutions to achieve desired social objectives even if the agents behave strategically for their own interests.However, existing studies mostly focus on ",{"id":615,"funder":7,"programme":8,"title":616,"piName":10,"institution":567,"country":41,"year":13,"amount":42,"abstract":617},"cordis-european-research-council-award-677582","Nanobody-targeted photodynamic therapy to kill cancer","Current cancer therapies often fail to cure patients. Ideally, therapy should locally eradicate cancer and should be capable of inducing long term protection, through activation of the immune system. Photodynamic therapy (PDT) is a treatment approach in which cancer cells are killed with compounds, named photosensitizers that are activated locally through light exposure. Importantly, PDT eradication of cancers commonly involves the immune system. However, current photosensitizers lack cancer spe",{"id":619,"funder":7,"programme":8,"title":620,"piName":10,"institution":621,"country":12,"year":13,"amount":622,"abstract":623},"cordis-european-research-council-award-676832","A Minimal-Tag Bioorthogonal Labelling Approach to Protein Uptake, Traffic and Delivery","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€1,499,106","The ability to probe dynamic cellular events that involve disease-associated proteins is limited, to a large extent, by the lack of development of a strategy that can use small coupling partners to react in chemoselective fashion with rapid kinetics that does not interfere with biological function(s) and localisation. In this application, I describe a conceptually new bioorthogonal-labelling approach that combines the introduction of a minimal non-canonical amino acid with chemoselective reactio",{"id":625,"funder":7,"programme":8,"title":626,"piName":10,"institution":627,"country":12,"year":13,"amount":628,"abstract":629},"cordis-european-research-council-award-678371","Isotope CYcling in the LABrador Sea","UNIVERSITY OF BRISTOL","€1,999,885","The high-latitude regions are experiencing some of the most rapid changes observed in recent decades: polar temperatures are rising twice as fast as the global mean and there are concerns about the impact of sea-ice and glacier retreat on global oceans and climate. The high-latitude North Atlantic is also a key region for ecologically and economically important natural resources such as fisheries. How these resources will change in the future depends strongly on the response of marine biogeochem",{"id":631,"funder":7,"programme":8,"title":632,"piName":10,"institution":633,"country":12,"year":13,"amount":634,"abstract":635},"cordis-european-research-council-award-677623","Regulation of lymphocyte biology by ubiquitin and ubiquitin like modifiers","UNIVERSITY OF DUNDEE","€1,499,987","T lymphocytes are key cells of the adaptive immune system that protect us against pathogens and malignant cells. T cell activation and differentiation are tightly controlled processes and deregulation can result in lymphomas, autoimmunity and inflammation. Hence, the biochemical events regulating lymphocyte biology have long been a topic of intense research, which has been focussed predominantly on protein phosphorylation. I hypothesize that there are crucial roles undiscovered in T cells for ot",{"id":637,"funder":7,"programme":8,"title":638,"piName":10,"institution":639,"country":12,"year":13,"amount":10,"abstract":640},"cordis-european-research-council-award-679689","New Science and Technology of Artificial Layered Structures and Devices","THE UNIVERSITY OF MANCHESTER","The extensive and growing library of layered crystals opens up the exciting possibility of exfoliating them into single atomic layers and stacking these atomic layers back together in new sequences to fabricate a new class of artificial van der Waals solids, with novel properties and functionalities. The principal objectives of this proposal are to study the fundamental physics and chemistry of novel materials, structures and devices synthesised by assembling different two-dimensional (2D) cryst",{"id":642,"funder":7,"programme":8,"title":643,"piName":10,"institution":644,"country":41,"year":13,"amount":10,"abstract":645},"cordis-european-research-council-award-678623","Peptide-derived bioavailable macrocycles as inhibitors of protein-RNA and protein-protein interactions","STICHTING VU","The objective of this proposal is the elucidation of general principles for the design of bioavailable peptide-derived macrocyclic compounds and their use for the development of inhibitors of protein‒protein (PPI) and protein‒RNA interactions (PRI). Over the last decade, drug discovery faced the problem of decreasing success rates which is mainly caused by the fact that numerous novel biological targets are reluctant to classic small molecule modulation. In particular, that holds true for PPIs a",{"id":647,"funder":7,"programme":8,"title":648,"piName":10,"institution":649,"country":145,"year":13,"amount":10,"abstract":650},"cordis-european-research-council-award-677559","Shaping of the Human Immune System by Primal Environmental Exposures In the Newborn Child","KAROLINSKA INSTITUTET","Immune systems are highly variable, but the sources of this variation are poorly understood. Genetic variation only explains a minor fraction of this, and we are unable to accurately predict the risk of immune mediated disease or severe infection in any given individual. I recently found that immune cells and proteins in healthy twins vary because of non-heritable influences (infections, vaccines, microbiota etc.), with only minor influences from heritable factors (Brodin, et al, Cell 2015). Whe",{"id":652,"funder":7,"programme":8,"title":653,"piName":10,"institution":341,"country":41,"year":13,"amount":654,"abstract":655},"cordis-european-research-council-award-677061","Accurate simulations of strongly correlated systems with tensor network methods","€1,499,909","This project aims to achieve ground-breaking advances in the biggest challenge in computational condensed matter physics: the accurate simulation of strongly correlated systems (SCS), which give rise to fascinating phenomena such as high-Tc superconductivity (HTSC), quantum spin liquids with topological order, and other exotic phases of matter. While for one-dimensional (1D) systems tremendous progress has been made thanks to the famous density-matrix renormalization group (DMRG) method, in high",{"id":657,"funder":7,"programme":8,"title":658,"piName":10,"institution":659,"country":12,"year":13,"amount":660,"abstract":661},"cordis-european-research-council-award-680176","SCALEFORES: Scaling Rules For Ecosystem Service Mapping","UNIVERSITY OF SOUTHAMPTON","€1,483,096","It is now widely recognized that sustainably managing ecosystem services – the benefits humans obtain from nature – is essential for humanity’s prospects in the 21st century and beyond. However, at present there is little data on the distribution of most services in most places.To date, the discipline of ecosystem service mapping has tried overcome this lack of data by using proxies to map ecosystem services based on our perceived understanding of ecosystem services from small-scale studies. How",{"id":663,"funder":7,"programme":8,"title":664,"piName":10,"institution":665,"country":120,"year":13,"amount":666,"abstract":667},"cordis-european-research-council-award-676828","The value of mothers to society: responses to motherhood and child rearing practices in prehistoric Europe","OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN","€1,499,680","Analysing the link between reproduction and women’s social status, this project explores social responses to pregnancy, birth and childrearing from the late Neolithic to the late Iron Age (c.3000-15 BC) through case studies in central Europe. Motherhood and childrearing, often seen as natural, mundane and inevitable parts of women’s lives, are also cultural and historically contingent practices that build the foundations of societies. Exploring the value of mothers to society will aid in underst",{"id":669,"funder":7,"programme":8,"title":670,"piName":10,"institution":307,"country":138,"year":13,"amount":671,"abstract":672},"cordis-european-research-council-award-677804","Take control! Towards novel training regimes enhancing inhibition and impulse control in health and psychiatric disease","€1,498,625","Self-control is at the heart of human nature and enables us to resist temptations. Several clinical disorders are characterized by an inability to control oneself, e.g. addiction and other impulse-related disorders. Since these psychiatric diseases are highly debilitating and cause substantial economic costs, any means of enhancing self-control is of high value for society at large. To date the view prevails that inhibition and therewith self-control is untrainable. Contrary to this, the applica",{"id":674,"funder":7,"programme":8,"title":675,"piName":10,"institution":676,"country":113,"year":13,"amount":677,"abstract":678},"cordis-european-research-council-award-679371","Global Encounters between China and Europe: Trade Networks, Consumption and Cultural Exchanges in Macau and Marseille (1680-1840)","UNIVERSIDAD PABLO DE OLAVIDE","€1,499,625","In the last decade the approaches of the global history have been emphasized in order to visualize the progress, form and method which historians have undertaken when carrying out ambitious research projects to analyse and compare diverse geographical and cultural areas of Asia and Europe. But when dealing with comparisons and cross-cultural studies in Europe and Asia, some scholarly works have exceeded of ambiguities when defining geographical units as well as chronology. In this project I exam",{"id":680,"funder":7,"programme":8,"title":681,"piName":10,"institution":594,"country":158,"year":13,"amount":682,"abstract":683},"cordis-european-research-council-award-678765","Combinatorial Aspects of Computational Geometry","€1,303,750","The project focuses on the interface between computational and combinatorial geometry. Geometric problems emerge in a variety of computational fields that interact with the physical world.The performance of geometric algorithms is determined by the description complexity of theirunderlying combinatorial structures. Hence, most theoretical challenges faced by computational geometryare of a distinctly combinatorial nature.In the past two decades, computational geometry has been revolutionized by t",{"id":685,"funder":7,"programme":8,"title":686,"piName":10,"institution":687,"country":12,"year":13,"amount":688,"abstract":689},"cordis-european-research-council-award-679891","Intelligent functional glazing with self-cleaning properties to improve the energy efficiency of the built environment","UNIVERSITY COLLEGE LONDON","€1,762,823","The latest forecast by the International Energy Agency predicts that the CO2 emissions from the built environment will reach 15.2Gt in 2050, double their 2007 levels. Buildings consume 40% of the primary energy in developed countries with heating and cooling alone accounting for 63% of the energy spent indoors. These trends are on an ascending trajectory - e.g. the average energy demand for air-conditioning has been growing by ~17% per year in the EU. Counterbalancing actions are urgently requir",{"id":691,"funder":7,"programme":8,"title":692,"piName":10,"institution":187,"country":158,"year":13,"amount":693,"abstract":694},"cordis-european-research-council-award-678702","VISUALIZATION OF TOPOLGICAL STATES IN PRISTINE NANOWIRES","€1,750,000","Topological phases of matter have been at the center of intense scientific research. Over the past decade this has led to the discovery of dozens of topological materials with exotic boundary states. In three dimensional topological phases, scanning tunneling microscopy (STM) has been instrumental in unveiling the unusual properties of these surface states. This success, however, did not encompass lower dimensional topological systems. The main reason is surface contamination which is disruptive",{"id":696,"funder":7,"programme":8,"title":697,"piName":10,"institution":193,"country":169,"year":13,"amount":698,"abstract":699},"cordis-european-research-council-award-679843","Smart Monitoring, Inspection and Life-Cycle Assessment of Wind Turbines","€1,486,224","The excessive energy consumption that Europe is faced with, calls for sustainable resource management and policy-making. Amongst renewable sources of the global energy pool, wind energy holds the lead. Nonetheless, wind turbine (WT) facilities are conjoined with a number of shortcomings relating to their short life-span and the lack of efficient management schemes. With a number of WTs currently reaching their design span, stakeholders and policy makers are convinced of the necessity for reliabl",{"id":701,"funder":7,"programme":8,"title":702,"piName":10,"institution":703,"country":41,"year":13,"amount":42,"abstract":704},"cordis-european-research-council-award-677601","Neural decisions under uncertainty","STICHTING RADBOUD UNIVERSITEIT","Virtually anything we sense, think and do is uncertain. For instance, when driving a car, you often need to determine how close you are to the car in front of you. It is near impossible to estimate this distance with absolute certainty – but it is possible to guess and even to estimate the uncertainty associated with that guess. Accordingly, we reduce speed when driving at night, because we realize perceived distance is more uncertain in the dark than on a sunny, clear day. How do we infer that ",{"id":706,"funder":7,"programme":8,"title":707,"piName":10,"institution":621,"country":12,"year":13,"amount":42,"abstract":708},"cordis-european-research-council-award-677501","Less is more: Single Cell Analysis of Zebrafish Blood Development","Blood stem cells need to both perpetuate themselves (self-renew) and differentiate into all mature blood cells to maintain blood formation throughout life. However, it is unclear how the underlying gene regulatory network maintains this population of self-renewing and differentiating stem cells, and how it accommodates the transition from a stem cell to a mature blood cell. Our current knowledge of transcriptomes of various blood cell types has mainly been advanced by population-level analysis. ",{"id":710,"funder":7,"programme":8,"title":711,"piName":10,"institution":712,"country":363,"year":13,"amount":10,"abstract":713},"cordis-european-research-council-award-679033","Exploiting vortices to suppress dispersion and reach new separation power boundaries","VRIJE UNIVERSITEIT BRUSSEL","The 21st century is expected to develop towards a society depending ever and ever more on (bio-)chemical measurements of fluids and matrices that are so complex they are well beyond the current analytical capabilities. Incremental improvements can no longer satisfy the current needs of e.g. the proteomics field, requiring the separation of tens of thousands of components. The pace of progress in these fields is therefore predominantly determined by that of analytical tools, whereby liquid chroma",{"id":715,"funder":7,"programme":8,"title":716,"piName":10,"institution":717,"country":138,"year":13,"amount":718,"abstract":719},"cordis-european-research-council-award-677819","Brain and body rhythms: on the relationship between movement and percept","JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG","€1,422,907","Exciting findings from animal electrophysiological research in the last years suggest that an increased rate of body movements results in an enhanced response of neurons within the visual system despite the absence of visual changes. It is unclear why such modulation occurs in areas which process visual input. In humans, little is known about the influence of body movements on sensory brain areas mainly due to the technical challenges of measuring brain responses during pronounced muscle activit",{"id":721,"funder":7,"programme":8,"title":722,"piName":10,"institution":644,"country":41,"year":13,"amount":723,"abstract":724},"cordis-european-research-council-award-679399","The mind's eye: How expectation and attention shape perception","€1,499,938","Perception is more than meet’s the eye; how we see the world is critically shaped by attention (what is relevant) and as a growing body of work indicates, by past experience (what is likely). Overturning the classical notion of perception as a largely bottom-up process, the idea that our brain is a prediction machine, continually trying to predict what is ‘out there’ based on past experience, is quickly growing in stature and influence. Yet, little is still known about how predictions shape perc",{"id":726,"funder":7,"programme":8,"title":727,"piName":10,"institution":193,"country":169,"year":13,"amount":728,"abstract":729},"cordis-european-research-council-award-678880","Data-centric Parallel Programming","€1,499,672","We address a fundamental and increasingly important challenge in computer science: how to program large-scale heterogeneous parallel computers. Society relies on these computers to satisfy the growing demands of important applications such as drug design, weather prediction, and big data analytics. Architectural trends make heterogeneous parallel processors the fundamental building blocks of computing platforms ranging from quad-core laptops to million-core supercomputers; failing to exploit the",{"id":731,"funder":7,"programme":8,"title":732,"piName":10,"institution":733,"country":151,"year":13,"amount":734,"abstract":735},"cordis-european-research-council-award-678151","Hybrid immune-eluding nanocrystals as smart and active theranostic weapons against cancer","POLITECNICO DI TORINO","€1,489,219","Nanomedicine tools for cancer treatment comprise many nanosized systems, so far developed with smart functions such as efficient drug delivery and cell targeting abilities. However they remain still undercharacterized in terms of immunogenicity, potential toxicity due to the materials itself or the unwanted release of drugs. To overcome these challenges this project aims to develop a new generation of multifunctional therapeutic and diagnostic (thus theranostics) nanosystems displaying non-immun",{"id":737,"funder":7,"programme":8,"title":738,"piName":10,"institution":739,"country":120,"year":13,"amount":42,"abstract":740},"cordis-european-research-council-award-678883","Cleave and couple: Fully sustainable catalytic conversion of renewable resources to amines","UNIVERSITAET GRAZ","Amines are crucially important classes of chemicals, widely present in pharmaceuticals, agrochemicals and surfactants. Yet, surprisingly, a systematic approach to obtaining this essential class of compounds from renewables has not been realized to date. The aim of this proposal is to enable chemical pathways for the production of amines through alcohols from renewable resources, preferably lignocellulose waste. Two key scientific challenges will be addressed: The development of efficient cleavag",{"id":742,"funder":7,"programme":8,"title":743,"piName":10,"institution":157,"country":158,"year":13,"amount":744,"abstract":745},"cordis-european-research-council-award-678169","Rational Design of Photoreceptor Mutants with Desired Photochemical Properties","€1,397,475","From a technological viewpoint photoreceptor proteins, the light-sensitive proteins involved in the sensing and response to light in a variety of organisms, represent biological light converters. Hence they are successfully utilized in a number of technological applications, e.g. the green-fluorescent protein used to visualize spatial and temporal information in cells. However, despite the ground-breaking nature of this utilization in life science and other disciplines, the attempts to design a ",{"id":747,"funder":7,"programme":8,"title":748,"piName":10,"institution":187,"country":158,"year":13,"amount":42,"abstract":749},"cordis-european-research-council-award-677748","Revealing the ubiquitin and ubiquitin-like modification landscape in health and disease","Post-translational modifications (PTMs) of proteins are a major tool that the cell uses to monitor events and initiate appropriate responses. While a protein is defined by its backbone of amino acid sequence, its function is often determined by PTMs, which specify stability, activity, or cellular localization. Among PTMs, ubiquitin and ubiquitin-like (Ubl) modifications were shown to regulate a variety of fundamental cellular processes such as cell division and differentiation. Aberrations in th",{"id":751,"funder":7,"programme":8,"title":752,"piName":10,"institution":753,"country":754,"year":13,"amount":755,"abstract":756},"cordis-european-research-council-award-677651","Technology transfer between modern algorithmic paradigms","UNIWERSYTET WARSZAWSKI","PL","€1,417,625","The two most recognized algorithmic paradigms of dealing with NP-hard problems in theoretical computer science nowadays are approximation algorithms and fixed parameter tractability (FPT). Despite the fact that both fields are by now developed, they have grown mostly on their own. In our opinion the two fields have critical mass allowing for synergy effects to appear when using techniques from one area to obtain results in the other, which is the main theme of the project.Furthermore, practical ",{"id":758,"funder":7,"programme":8,"title":759,"piName":10,"institution":627,"country":12,"year":13,"amount":760,"abstract":761},"cordis-european-research-council-award-677055","Comparative Analysis of Social Spaces in Post-Industrial Nations","€1,467,038","The proposed research has two overarching objectives. First, it aims to examine whether it is possible and appropriate to extend a novel way of measuring social class recently devised for the United Kingdom to other post-industrial nations for the purposes of cross-national comparative research. If it is, the project will begin to explore, through secondary and primary analysis of large-scale survey data, the different shapes and trajectories of the class structures – or ‘social spaces’ – of var",{"id":763,"funder":7,"programme":8,"title":764,"piName":10,"institution":765,"country":48,"year":13,"amount":10,"abstract":766},"cordis-european-research-council-award-715747","Constructing line bundles on algebraic varieties -- around conjectures of Tate and Grothendieck","UNIVERSITE PARIS-SACLAY","The goal of this project is to investigate two conjectures in arithmetic geometry pertaining to the geometry of projective varieties over finite and number fields. These two conjectures, formulated by Tate and Grothendieck in the 1960s, predict which cohomology classes are chern classes of line bundles. They both form an arithmetic counterpart of a theorem of Lefschetz, proved in the 1940s, which itself is the only known case of the Hodge conjecture. These two long-standing conjectures are one o",{"id":768,"funder":7,"programme":8,"title":769,"piName":10,"institution":336,"country":48,"year":13,"amount":42,"abstract":770},"cordis-european-research-council-award-679734","Structural and biochemical studies on the regulation of transcription during elongation","During the first step of gene expression, a universally conserved enzyme called RNA Polymerase (RNAP) transcribes RNA from a DNA template in every cell. Transcription is a fundamental, yet incompletely understood process. Because of its central role, the bacterial transcription machinery is also a prime drug target. Crystal structures of RNAP core as well as RNAP elongation complexes (ECs) have revolutionized our understanding of transcription. This groundwork paved the way to address more compl",{"id":772,"funder":7,"programme":8,"title":773,"piName":10,"institution":774,"country":151,"year":13,"amount":10,"abstract":775},"cordis-european-research-council-award-679183","Entanglement distribution via Semiconductor-Piezoelectric Quantum-Dot Relays","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","The development of scalable quantum devices that generate and distribute quantum entanglement over distant parties will bring about a revolution in communication science and technology. Epitaxial quantum dots (QDs) embedded in conventional diodes are arguably the most attractive quantum devices, since they combine the capability of QDs to deliver triggered and high-quality entangled photons with the tools of the mature semiconductor technology. However, it is at present impossible to use remote ",{"id":777,"funder":7,"programme":8,"title":778,"piName":10,"institution":779,"country":151,"year":13,"amount":780,"abstract":781},"cordis-european-research-council-award-678783","A Global Approach to Paid Domestic Work and Social Inequalities","UNIVERSITA CA' FOSCARI  VENEZIA","€1,199,976","How does globalisation impact the construction of social inequality? DomEQUAL tackles this question through a study on paid domestic work (PDW). Of the 52.6 million PDWs in the world today, 43 million are women and 7 million are children. The multidimensional transformations brought about by globalisation with the intensification of international migration, the urbanisation of rural and indigenous populations, and changes in household organisation and welfare regimes have a massive impact on PDW",{"id":783,"funder":7,"programme":8,"title":784,"piName":10,"institution":785,"country":138,"year":13,"amount":10,"abstract":786},"cordis-european-research-council-award-679288","Unique Light-Matter Interactions with Two-Dimensional Materials","CARL VON OSSIETZKY UNIVERSITAET OLDENBURG","Controlling light- and matter excitations down to the microscopic scale is one major challenge in modern optics. Applications arising from this field, such as novel coherent- and quantum light sources have the potential to affect our daily life. One particularly appealing material platform in quantum physics consists of  monolayer crystals. The most prominent species, graphene, however remains rather unappealing for photonic applications due to the lack of an electronic bandgap in its pristine f",{"id":788,"funder":7,"programme":8,"title":789,"piName":10,"institution":790,"country":791,"year":13,"amount":10,"abstract":792},"cordis-european-research-council-award-677931","Breaking the paradigm: A new approach to understanding and controlling combustion instabilities","NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU","NO","It is well known that current and future low-emission combustion concepts for gas turbines are prone to thermoacoustic instabilities. These give rise to large pressure fluctuations that can drastically reduce the operable range and threaten the structural integrity of stationary gas turbines and aero engines. In the last 6 years the development of laboratory-scale annular combustors and high-performance computing based on Large Eddy Simulations (LES) have been able to reproduce thermoacoustic os",{"id":794,"funder":7,"programme":8,"title":795,"piName":10,"institution":796,"country":138,"year":13,"amount":10,"abstract":797},"cordis-european-research-council-award-714536","Precision measurements to discover new scalar and vector particles","TECHNISCHE UNIVERSITAT DORTMUND","The Standard Model of particle physics successfully describes all known particles and their interactions. However, questions like the nature of dark matter or the hierarchy of masses and couplings of quarks and leptons remain to be understood. Hence, one searches for new phenomena that will lead to a superior theory that can explain these questions. All such theories introduce additional quantum corrections. Decay rates of processes which are strongly suppressed in the Standard Model are highly ",{"id":799,"funder":7,"programme":8,"title":800,"piName":10,"institution":473,"country":12,"year":13,"amount":801,"abstract":802},"cordis-european-research-council-award-680088","New approaches to characterise Schistosoma mansoni infections persisting despite mass drug administration","€1,490,270","Neglected tropical diseases affect over 1.4 billion people and cause a greater disease burden than HIV\u002FAIDS. Despite extensive mass drug administration (MDA) schistosomiasis remains a major public health issue, with a socio-economic impact second only to malaria amongst parasites. I will evaluate novel strategies and new technologies to monitor the impact of MDA programmes, to identify threats to MDA effectiveness, and enhance control of schistosomiasis in sub-Saharan Africa.Specifically I will ",{"id":804,"funder":7,"programme":8,"title":805,"piName":10,"institution":467,"country":169,"year":13,"amount":42,"abstract":806},"cordis-european-research-council-award-714620","Bridging the gap between supramolecular chemistry and current synthetic challenges: Developing artificial catalysts for the tail-to-head terpene cyclization","Nature is a rich source of biologically active molecules, among which the largest and most diverse group of natural products are terpenes. Essential drugs like the cancer medication taxol\u002Fpaclitaxel or the malaria drug artemisinin belong to the terpene family. They are efficiently formed in nature through a so-called tail-to-head terpene cyclization. Chemists are not able to mimic this process with man-made catalysts. This proposal aims at closing this significant research gap by utilizing supra",{"id":808,"funder":7,"programme":8,"title":809,"piName":10,"institution":187,"country":158,"year":13,"amount":810,"abstract":811},"cordis-european-research-council-award-677715","Genetically Encoded Multicolor Reporter Systems For Multiplexed MRI","€1,478,284","In order to fully understand the complexity of biological processes that are reflected by simultaneous occurrences of intra and inter-cellular events, multiplexed imaging platforms are needed. Fluorescent reporter genes, with their “multicolor” imaging capabilities, have revolutionized science and their founders have been awarded the Nobel Prize. Nevertheless, the light signal source of these reporters, which restricts their use in deep tissues and in large animals (and potentially in humans), c",{"id":813,"funder":7,"programme":8,"title":814,"piName":10,"institution":815,"country":169,"year":13,"amount":816,"abstract":817},"cordis-european-research-council-award-677493","Forecasting the recurrence rate of volcanic eruptions","UNIVERSITE DE GENEVE","€1,458,192","Volcanic eruptions occur with a frequency that is inversely proportional to their magnitude. Datasets of natural volcanic events, currently used to determine the recurrence rate of volcanic eruptions are intrinsically biased. Combining physical modelling of processes with detailed statistical analysis has been demonstrated essential for assessing reliably the recurrence rate of natural hazards, such as floods and earthquakes. This would be the first attempt to apply a similar, integrated approac",{"id":819,"funder":7,"programme":8,"title":820,"piName":10,"institution":341,"country":41,"year":13,"amount":42,"abstract":821},"cordis-european-research-council-award-677323","Precision Multi-Scale Predictions for the LHC: Higgs, Jets and Supersymmetry","My project will boost the precision of theoretical predictions for collisions at the Large Hadron Collider. Precise predictions are crucial to further constrain the properties of the recently-discovered Higgs boson, and uncover a faint signal of Beyond-the-Standard Model physics. I will focus on the strong interactions, which dominate the theoretical uncertainty and play a role at multiple energy scales, including those related to the incoming protons, the hard scattering, the masses of (new) pa",{"id":823,"funder":7,"programme":8,"title":824,"piName":10,"institution":825,"country":138,"year":13,"amount":42,"abstract":826},"cordis-european-research-council-award-639961","Antibody-Mediated Therapy of HIV-1 Infection","KLINIKUM DER UNIVERSITAET ZU KOELN","Antibodies are destined to neutralize pathogens and can prevent and fight infectious diseases. Over the last years, advances in single B cell cloning resulted in the isolation of highly potent and broad HIV-1 neutralizing antibodies (bNAbs) that have been shown to prevent SHIV infection in non-human primates (NHPs). Recently, we have demonstrated that a combination of bNAbs can suppress HIV-1 replication in humanized mice, reducing viremia to undetectable levels. Moreover, bNAb therapy of SHIV-i",{"id":828,"funder":7,"programme":8,"title":829,"piName":10,"institution":644,"country":41,"year":13,"amount":10,"abstract":830},"cordis-european-research-council-award-680002","The Human Behavioral Immune System: Consequences for Health and Innovation","Modern innovations such as soap, condoms, and indoor plumbing have allowed billions of people to reduce their contact with viruses and bacteria and, as a result, dramatically increase length and quality of life. But how did members of the genus homo avoid pathogens for the two million years that preceded these technological innovations and, more broadly, discoveries that infectious disease is caused by microbes? And, importantly, how do any natural behavioral defenses against pathogens impact ou",{"id":832,"funder":7,"programme":8,"title":833,"piName":10,"institution":834,"country":138,"year":13,"amount":835,"abstract":836},"cordis-european-research-council-award-678073","Prenatal Stress and Programming of Newborn and Infant Telomere Biology and Cellular Aging","CHARITE - UNIVERSITAETSMEDIZIN BERLIN","€1,483,720","The long-term consequences of exposure to excess stress on the initiation and progression of many age-related diseases are well established. The period of intrauterine life represents among the most sensitive developmental windows, at which time the effects of stress may be transmitted inter-generationally from a mother to her as-yet-unborn child. The elucidation of mechanisms underlying such effects is an area of intense interest and investigation. Aging, by definition, occurs with advancing ag",{"id":838,"funder":7,"programme":8,"title":839,"piName":10,"institution":840,"country":12,"year":13,"amount":841,"abstract":842},"cordis-european-research-council-award-678733","Cracking the Pitch Code in Music and Language: Insights from Congenital Amusia and Autism Spectrum Disorders","THE UNIVERSITY OF READING","€1,488,814","Music and language share similar properties and are processed in overlapping brain regions. As a common information-bearing element in music and language, pitch plays an essential role in encoding musical melodies, signifying linguistic functions, and conveying emotions through music and speech. However, two distinct neurodevelopmental disorders, congenital amusia (CA) and autism spectrum disorders (ASD), affecting millions of people in Europe and worldwide, may selectively impair individuals’ a",{"id":844,"funder":7,"programme":8,"title":845,"piName":10,"institution":846,"country":169,"year":13,"amount":10,"abstract":847},"cordis-european-research-council-award-679881","The Role of Local Protein Degradation in Neurotransmitter Release and Homeostatic Plasticity","UNIVERSITAT ZURICH","While many neurons live for decades, the proteins that determine neural function have half-lives of hours to weeks. On the one hand, this allows for plastic changes during development and learning. On the other hand, this poses the question of how stable neural function can be achieved and maintained at all. Several neurological diseases, such as epilepsy or migraine, have been linked to uncontrolled neural function. However, the molecular mechanisms that stabilize nervous system function are po",{"id":849,"funder":7,"programme":8,"title":850,"piName":10,"institution":851,"country":754,"year":13,"amount":852,"abstract":853},"cordis-european-research-council-award-677120","Rigidity of groups and higher index theory","INSTYTUT MATEMATYCZNY POLSKIEJ AKADEMII NAUK","€880,625","The Atiyah-Singer index theorem was one of the most spectacular achievements of mathematics in the XXth century, connecting the analytic and topological properties of manifolds. The Baum-Connes conjecture is a hugely successful approach to generalizing the index theorem to a much broader setting. It has remarkable applications in topology and analysis. For instance, it implies the Novikov conjecture on the homotopy invariance of higher signatures of a closed manifold and the Kaplansky-Kadison co",{"id":855,"funder":7,"programme":8,"title":856,"piName":10,"institution":857,"country":754,"year":13,"amount":858,"abstract":859},"cordis-european-research-council-award-715148","Functional connectomics of the amygdala in social interactions of different valence","INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK","€1,312,500","Understanding how brain controls social interactions is one of the central goals of neuroscience. Whereas social interactions and their effects on the emotional state of an individual are relatively well described at the behavioral level, much less is known about neural mechanisms involved in these very complex phenomena, especially in the amygdala, a key structure processing emotions in the brain.Recent investigations, mainly on fear learning and extinction, have shown that there are highly spe",{"id":861,"funder":7,"programme":8,"title":862,"piName":10,"institution":863,"country":145,"year":13,"amount":42,"abstract":864},"cordis-european-research-council-award-678899","Elucidation of autophagy using novel chemical probes","UMEA UNIVERSITET","The interest on autophagy, an evolutionarily conserved process in eukaryotes, has enormously increased in the last years, since autophagy is involved in many diseases such as cancer and neurodegenerative disorders. Autophagosome formation is the key process in autophagy. Despite extensive work, the model of autophagosome formation is not yet well established. Some important questions on autophagosome biogenesis remain to be elusive, such as where the bona fide marker protein of autophagosome, LC",{"id":866,"funder":7,"programme":8,"title":867,"piName":10,"institution":868,"country":138,"year":13,"amount":869,"abstract":870},"cordis-european-research-council-award-678652","Gravity, Inflation, and Galaxies: Fundamental Physics with Large-Scale Structure","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€1,330,625","Over the past two decades, a data-driven revolution has occurred in our understanding of the origin and evolution of our Universe and the structure within it. During this period, cosmology has evolved from a speculative branch of theoretical physics into precision science at the intersection of gravity, particle- and astrophysics. Despite all we have learned, we still do not understand why the Universe accelerates, and how the structure in the Universe originated. Recent breakthrough research, w",{"id":872,"funder":7,"programme":8,"title":873,"piName":10,"institution":567,"country":41,"year":13,"amount":874,"abstract":875},"cordis-european-research-council-award-676819","Climbing the Asian Water Tower","€1,499,631","The water cycle in the Himalaya is poorly understood because of its extreme topography that results in complex interactions between climate and water stored in snow and glaciers. Hydrological extremes in the greater Himalayas regularly cause great damage, e.g. the Pakistan floods in 2010, while the Himalayas also supply water to over 25% of the global population. So, the stakes are high and an accurate understanding of the Himalayan water cycle is imperative. The discovery of the monumental erro",{"id":877,"funder":7,"programme":8,"title":878,"piName":10,"institution":857,"country":754,"year":13,"amount":879,"abstract":880},"cordis-european-research-council-award-678119","Signaling Cascades in Metabolic Diseases","€1,499,128","Over 380 million people suffer from diabetes worldwide, with majority of cases being attributed to type 2 diabetes (T2D). Obesity is a major risk factor predisposing to the development of this disease. T2D is characterized by peripheral insulin resistance in combination with relative insulin deficiency that results in hyperglycemia and hyperlipidemia. Liver and adipose tissue are central for regulation of glucose and lipids levels. However, during T2D the hepatic glucose uptake is reduced while ",{"id":882,"funder":7,"programme":8,"title":883,"piName":10,"institution":703,"country":41,"year":13,"amount":884,"abstract":885},"cordis-european-research-council-award-678286","Visual perception in Context","€1,499,421","Everything occurs in a context. We see a car in the context of a street scene and a stove in the context of a kitchen. Context greatly helps the processing of individual objects. Surprisingly however, context hardly plays a role in most models of visual perception, which treat perception as a largely bottom-up categorization process. In this research proposal, I will examine how context changes the cortical computations that give rise to visual perception, focusing on contextual modulations in s",{"id":887,"funder":7,"programme":8,"title":888,"piName":10,"institution":889,"country":151,"year":13,"amount":890,"abstract":891},"cordis-european-research-council-award-679010","The reading brain as a statistical learning machine","SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE","€1,498,210","Despite written language is not part of our genetic endowment, literate adults process an impressive amount of information as they read, and do that extremely flawlessly and nearly error-free. How this happens is largely unknown, and represents a fundamental issue for theories of human learning. Building on data from nonhuman primates, human infants and psycholinguistic experiments on word internal structure, STATLEARN tests the hypothesis that one fundamental cognitive mechanism underlies visua",{"id":893,"funder":7,"programme":8,"title":894,"piName":10,"institution":357,"country":138,"year":13,"amount":895,"abstract":896},"cordis-european-research-council-award-678341","Frontiers of Usable Security – Principles and Methods for Administrator and Developer Usable Security Research","€1,498,976","Usability problems are a major cause of many of today’s IT-security incidents. Security systems are often too complicated, time-consuming, and error prone. For more than a decade researchers in the domain of usable security (USEC) have attempted to combat these problems by conducting interdisciplinary research focusing on the root causes of the problems and on the creation of usable security mechanisms. While major improvements have been made, to date USEC research has focused almost entirely on",{"id":898,"funder":7,"programme":8,"title":899,"piName":10,"institution":900,"country":48,"year":13,"amount":91,"abstract":901},"cordis-european-research-council-award-678177","Formal specification and verification of distributed data structures","UNIVERSITE PARIS CITE","The future of the computing technology relies on fast access, transformation, and exchange of data across large-scale networks such as the Internet. The design of software systems that support high-frequency parallel accesses to high-quantity data is a fundamental challenge. As more scalable alternatives to traditional relational databases, distributed data structures (DDSs) are at the basis of a wide range of automated services, for now, and for the foreseeable future. This proposal aims to imp",{"id":903,"funder":7,"programme":8,"title":904,"piName":10,"institution":905,"country":138,"year":13,"amount":906,"abstract":907},"cordis-european-research-council-award-677912","The origin of heavy elements: a nuclear physics and astrophysics challenge","TECHNISCHE UNIVERSITAT DARMSTADT","€1,446,875","Where in the universe are heavy elements synthesized? How are these elements produced? These are two exciting and interdisciplinary questions in nuclear astrophysics today and will be investigated in my ERC project EUROPIUM. The favored astrophysical sites are neutrino-driven winds following core-collapse supernovae and neutron star mergers, where extreme conditions enable the rapid neutron capture process (r-process). We will perform long-time multidimensional simulations of these two scenarios",{"id":909,"funder":7,"programme":8,"title":910,"piName":10,"institution":911,"country":41,"year":13,"amount":912,"abstract":913},"cordis-european-research-council-award-678194","Forging Advanced Liquid-Crystal Coronagraphs Optimized for Novel Exoplanet Research","UNIVERSITEIT LEIDEN","€1,499,522","The 39-m European Extremely Large Telescope (E-ELT) has the potential to directly observe and characterize habitable exoplanets, but current technologies are unable to sufficiently suppress the starlight very close to the star. I propose to develop a novel instrumental approach with breakthrough contrast performance by combining coronagraphs based on brand-new liquid crystal technology, and sensitive imaging polarimetry. The novel coronagraphs will provide an achromatic rejection of starlight ev",{"id":915,"funder":7,"programme":8,"title":916,"piName":10,"institution":868,"country":138,"year":13,"amount":917,"abstract":918},"cordis-european-research-council-award-679787","Are social skills determined by early live experiences?","€1,495,000","Social bonding success in life impacts on health, survival and fitness. It is proposed that early and later social experience as well as heritable factors determine social bonding abilities in adulthood, although the relative influence of each is unclear. In humans, the resulting uncertainty likely impedes psychological and psychiatric assessment and therapy. One problem hampering progress for human studies is that social bonding success is hard to objectively quantify, particularly in adults. I",{"id":920,"funder":7,"programme":8,"title":921,"piName":10,"institution":900,"country":48,"year":13,"amount":922,"abstract":923},"cordis-european-research-council-award-679254","Podocyte Adaptation Proliferation and Ageing","€1,479,260","My research project is focused on the biology of the podocyte during chronic kidney disease progression, one of the major public health challenges of the 21st Century. The podocyte is a highly specialized cell with foot processes expansion that function as vasculature-supporting cells, producing basement membrane components and a number of vascular growth factors. These cells play an essential role in renal physiology but their unique localization, as the primary filter, exposes them to many str",{"id":925,"funder":7,"programme":8,"title":926,"piName":10,"institution":187,"country":158,"year":13,"amount":927,"abstract":928},"cordis-european-research-council-award-714023","Cracking the epitranscriptome","€1,402,666","Over 100 types of distinct modifications are catalyzed on RNA molecules post-transcriptionally. In an analogous manner to well-studied chemical modifications on proteins or DNA, modifications on RNA - and particularly on mRNA - harbor the exciting potential of regulating the complex and interlinked life cycle of these molecules. The most abundant modification in mammalian and yeast mRNA is N6-methyladenosine (m6A). We have pioneered approaches for mapping m6A in a transcriptome wide manner, and ",{"id":930,"funder":7,"programme":8,"title":931,"piName":10,"institution":932,"country":169,"year":13,"amount":933,"abstract":934},"cordis-european-research-council-award-679330","Characterizing Adaptation and Migration Events with Modern and Ancient Genomes","UNIVERSITE DE LAUSANNE","€1,498,478","BACKGROUND Ancient DNA research has recently entered the genomics era. Performing“ancient population genomics” is now technically possible. Utilizing the temporal aspect of thisnew data, we can address fundamental evolutionary questions such as the amount of selectionacting on the genome or the mode and tempo of the colonization of the world. AIMS The overall goal of the proposed research is to (i) generate and analyse data to answer two long standing questions in human evolution: understanding ",{"id":936,"funder":7,"programme":8,"title":937,"piName":10,"institution":938,"country":549,"year":13,"amount":939,"abstract":940},"cordis-european-research-council-award-715734","Hydrodynamic Limits and Equilibrium Fluctuations: universality from stochastic systems","INSTITUTO SUPERIOR TECNICO","€1,179,496","A classical problem in the field of interacting particle systems (IPS) is to derive the macroscopic laws of the thermodynamical quantities of a physical system by considering an underlying microscopic dynamics which is composed of particles that move according to some prescribed stochastic, or deterministic, law. The macroscopic laws can be partial differential equations (PDE) or stochastic PDE (SPDE) depending on whether one is looking at the convergence to the mean or to the fluctuations aroun",{"id":942,"funder":7,"programme":8,"title":943,"piName":10,"institution":944,"country":282,"year":13,"amount":945,"abstract":946},"cordis-european-research-council-award-677467","Immune Response and Social Cognition in Schizophrenia","UNIVERSITY OF GALWAY","€1,477,622","Schizophrenia, affecting 0.5-1% of the population, is ranked by the World Health Organisation as more disabling than paraplegia or blindness in 18-34 year olds. Current treatments, developed over 50 years ago, are only partly effective in treating this disability, and new treatments are lacking. To address this treatment impasse, this project aims to develop and test a novel immune based model of deficits in social cognition – the set of mental operations that underlie social interactions (e.g. ",{"id":948,"funder":7,"programme":8,"title":949,"piName":10,"institution":588,"country":158,"year":13,"amount":950,"abstract":951},"cordis-european-research-council-award-677352","Natural Language Programming: Turning Text into Executable Code","€1,449,375","Can we program computers in our native tongue? This idea, termed natural language programming, has attracted attention almost since the inception of computers themselves.  From the point of view of software engineering (SE), efforts to program in natural language (NL) have relied thus far on controlled natural languages (CNL) -- small unambiguous fragments of English with strict grammars and limited expressivity. Is it possible to replace CNLs with truly natural, human language?  From the point ",{"id":953,"funder":7,"programme":8,"title":954,"piName":10,"institution":621,"country":12,"year":13,"amount":955,"abstract":956},"cordis-european-research-council-award-677758","Contexts of and Relations between Early Writing Systems","€1,472,519","Contexts of and Relations between Early Writing SystemsThis project takes an innovative and interdisciplinary approach to the history of writing, redressing lingering problems that have hampered previous research and developing new methodologies for studying scripts and their social context. The staff on the project will work on specific case studies relating to inscriptions of the ancient Aegean, Eastern Mediterranean and Levant (c.2000-600 BC), developing a new and much deeper understanding of",{"id":958,"funder":7,"programme":8,"title":959,"piName":10,"institution":960,"country":41,"year":13,"amount":81,"abstract":961},"cordis-european-research-council-award-679190","Skilled Intentionality for 'Higher' Embodied Cognition: Joining forces with a field of affordances in flux","STICHTING AMSTERDAM UMC","In many situations experts act adequately, yet without deliberation. Architects e.g, immediately sense opportunities offered by the site of a new project. One could label these manifestations of expert intuition as ‘higher-level’ cognition, but still these experts act unreflectively. The aim of my project is to develop the Skilled Intentionality Framework (SIF), a new conceptual framework for the field of embodied\u002Fenactive cognitive science (Chemero, 2009; Thompson, 2007). I argue that affordanc",{"id":963,"funder":7,"programme":8,"title":964,"piName":10,"institution":352,"country":80,"year":13,"amount":965,"abstract":966},"cordis-european-research-council-award-677152","Northern Europe's timber resource - chronology, origin and exploitation","€1,472,199","Empirical evidence for the history of the exploitation of the timber resource in Northern Europe is stored in the material record. Archaeological finds, art-historical objects and built heritage have provided us with an extensive dataset of precisely dated wood from heritage contexts. This material is the key to details about the usage, condition and availability of the timber resource and details of trade in timber, including the maritime timber trade, from c. AD 1100 to 1700. Tree-ring studies",{"id":968,"funder":7,"programme":8,"title":969,"piName":10,"institution":193,"country":169,"year":13,"amount":42,"abstract":970},"cordis-european-research-council-award-680070","Development of Quantitative Metrologies to Guide Lithium Ion Battery Manufacturing","Lithium ion batteries offer tremendous potential as an enabling technology for sustainable transportation and development. However, their widespread usage as the energy storage solution for electric mobility and grid-level integration of renewables is impeded by the fact that current state-of-the-art lithium ion batteries have energy densities that are too small, charge- and discharge rates that are too low, and costs that are too high. Highly publicized instances of catastrophic failure of lith",{"id":972,"funder":7,"programme":8,"title":973,"piName":10,"institution":974,"country":138,"year":13,"amount":975,"abstract":976},"cordis-european-research-council-award-677448","Targeting perivascular myofibroblast progenitors to treat cardiac fibrosis and heart failure in chronic kidney disease","UNIVERSITAETSKLINIKUM AACHEN","€1,497,888","Chronic kidney disease (CKD) is a growing public health problem with a massively increased cardiovascular mortality. Patients with advanced CKD mostly die from sudden cardiac death and recurrent heart failure due to premature cardiac aging with hypertrophy, fibrosis, and capillary rarefaction. I have recently identified the long sought key cardiac myofibroblast progenitor population, an emerging breakthrough that carries the potential to develop novel targeted therapeutics. Genetic ablation of t",{"id":978,"funder":7,"programme":8,"title":979,"piName":10,"institution":980,"country":41,"year":13,"amount":42,"abstract":981},"cordis-european-research-council-award-677936","Single molecule observation and manipulation of gene expression dynamics to dissect mechanisms of cell cycle entry","KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW","Gene expression is a highly dynamic and inherently variable process. Yet, it needs to be tightly regulated, especially during the cell cycle, when continuous large-scale changes occur to the proteome. Even small deviations in the expression levels of a single protein in individual cells can de-regulate cell cycle entry and promote tumorigenesis. Here, I will develop new technology to study gene expression dynamics in single cells to uncover how active regulation and stochastic variability shape ",{"id":983,"funder":7,"programme":8,"title":984,"piName":10,"institution":985,"country":138,"year":13,"amount":10,"abstract":986},"cordis-european-research-council-award-677661","Magnetic resonance imaging platform for probing fat microstructure","KLINIKUM DER TECHNISCHEN UNIVERSITÄT MÜNCHEN (TUM KLINIKUM)","Metabolic syndrome and osteoporosis are the two metabolic diseases with the highest and most rapidly growing prevalence, transforming them into a major global health and socioeconomic concern. Metabolic syndrome can be diagnosed with established biomarkers, but the selection of optimal prevention strategies for each individual patient is still problematic. Osteoporosis can be treated, but its current early diagnosis remains insufficient. The two diseases have been linked through the role of fat.",{"id":988,"funder":7,"programme":8,"title":989,"piName":10,"institution":990,"country":151,"year":13,"amount":991,"abstract":992},"cordis-european-research-council-award-679814","IMPROVING PHOTOSYNTHETIC SOLAR ENERGY CONVERSION IN MICROALGAL CULTURES FOR THE PRODUCTION OF BIOFUELS AND HIGH VALUE PRODUCTS","UNIVERSITA DEGLI STUDI DI VERONA","€1,441,875","Solar Energy is the most abundant renewable energy source available for our Planet. Light energy conversion into chemical energy by photosynthetic organisms is indeed the main conversion energy step, which originated high energy containing fossil deposits, now being depleted. By the way, plant or algae biomass may still be used to produce biofuels, as bio-ethanol, bio-diesel and bio-hydrogen. Microalgae exploitation for biofuels production have the considerable advantages of being sustainable an",{"id":994,"funder":7,"programme":8,"title":995,"piName":10,"institution":157,"country":158,"year":13,"amount":996,"abstract":997},"cordis-european-research-council-award-678921","Securing Internet Routing from the Ground Up","€1,468,200","The Internet is made up of dozens of thousands of smaller networks, called Autonomous Systems (ASes), ranging from multinational corporations to small businesses and schools, e.g., Google, Deutsche Telekom, AT&T, and Hebrew U. Routing between ASes is handled by the Border Gateway Protocol (BGP), which is the glue that holds the Internet together. Alarmingly, despite the Internet's critical societal and economic role, BGP routing is dangerously vulnerable to configuration errors and attacks, and,",{"id":999,"funder":7,"programme":8,"title":1000,"piName":10,"institution":1001,"country":138,"year":13,"amount":1002,"abstract":1003},"cordis-european-research-council-award-677232","ECOSYSTEM RESPONSES TO EXOTIC EARTHWORM INVASION IN NORTHERN NORTH AMERICAN FORESTS","UNIVERSITAET LEIPZIG","€1,498,620","Earth is experiencing substantial biodiversity losses at the global scale, while both species gains and losses are occurring locally and regionally. Nonrandom changes in species distributions could profoundly influence ecosystem functions and services. However, few experimental tests have examined the influences of invasive ecosystem engineers, which can have disproportionally strong impacts on native ecosystems. Invasive earthworms are a prime example of ecosystem engineers that influence many ",{"id":1005,"funder":7,"programme":8,"title":1006,"piName":10,"institution":1007,"country":113,"year":13,"amount":10,"abstract":1008},"cordis-european-research-council-award-679001","Network models for the computational design of proficient enzymes","UNIVERSITAT DE GIRONA","Billions of years of evolution have made enzymes superb catalysts capable of accelerating reactions by several orders of magnitude. The underlying physical principles of their extraordinary catalytic power still remains highly debated, which makes the alteration of natural enzyme activities towards synthetically useful targets a tremendous challenge for modern chemical biology. The routine design of enzymes will, however, have large socio-economic benefits, as because of the enzymatic advantages",{"id":1010,"funder":7,"programme":8,"title":1011,"piName":10,"institution":1012,"country":12,"year":13,"amount":1013,"abstract":1014},"cordis-european-research-council-award-677706","Evolution of white dwarfs with 3D model atmospheres","UNIVERSITY OF WARWICK","€1,454,650","The vast majority of stars will become white dwarfs at the end of the stellar life cycle. These remnants are precise cosmic clocks owing to their well constrained cooling rates. They provide one of the most sensitive tests of when baryonic structure formation began in the Universe. These compact matter laboratories also unravel the mass-loss in the post-main-sequence evolution and establish critical constraints for galactic evolution models. I will design a robust theoretical framework to shed n",{"id":1016,"funder":7,"programme":8,"title":1017,"piName":10,"institution":193,"country":169,"year":13,"amount":42,"abstract":1018},"cordis-european-research-council-award-680358","Learning from Big Code: Probabilistic Models, Analysis and Synthesis","The goal of this proposal is to fundamentally change the way we build and reason about software. We aim to develop new kinds of statistical programming systems that provide probabilistically likely solutions to tasks that are difficult or impossible to solve with traditional approaches.These statistical programming systems will be based on probabilistic models of massive codebases (also known as ``Big Code'') built via a combination of advanced programming languages and powerful machine learning",{"id":1020,"funder":7,"programme":8,"title":1021,"piName":10,"institution":1022,"country":12,"year":13,"amount":1023,"abstract":1024},"cordis-european-research-council-award-679747","Understanding the Complexity of Modern Financial Systems","LONDON BUSINESS SCHOOL","€1,498,947","The modern financial system has undergone immense transformation in recent years and is far more complex than ever before. In lockstep, financial regulation has also become more complex. This research proposal attempts to improve our understanding of potential drivers of this complexity and the implications of this change on the allocation of resources.Taking a positive rather than a normative approach, I will analyse post-crisis changes at both the micro- and at the macro-levels to create a bro",{"id":1026,"funder":7,"programme":8,"title":1027,"piName":10,"institution":868,"country":138,"year":13,"amount":1028,"abstract":1029},"cordis-european-research-council-award-679927","Imaging synaptic plasticity by ultra-high field magnetic resonance spectroscopy in health and psychiatric disease","€1,505,000","A large number of psychiatric disorders (major and bipolar depression (MDD \u002F BD), schizophrenia, obsessive-compulsive disorder (OCD), addiction, anxiety, attention deficit hyperactivity syndrome (ADHS), posttraumatic stress disorder (PTSD), autism) lack objective criteria for primary diagnosis, early differential diagnosis with regard to subtypes in treatment response and disease progression or effective therapy monitoring. Hence, the search for relevant biomarkers is of high importance. This pr",{"id":1031,"funder":7,"programme":8,"title":1032,"piName":10,"institution":868,"country":138,"year":13,"amount":42,"abstract":1033},"cordis-european-research-council-award-677770","Mechanisms of protein translocation in ER-associated protein degradation and the related protein import into the apicoplast of Plasmodium falciparum","The removal of misfolded proteins is an essential process in all cells. Failure to dispose of such proteins often results in disease. A particularly intriguing process serves to discard misfolded proteins from the endoplasmic reticulum (ER). The ER does not itself degrade proteins, so machinery has evolved that moves misfolded proteins into the cytosol where they can be degraded by the proteasome. This retro-translocation process is called ERAD (for ER-associated protein degradation). By compari",{"id":1035,"funder":7,"programme":8,"title":1036,"piName":10,"institution":451,"country":363,"year":13,"amount":1037,"abstract":1038},"cordis-european-research-council-award-716181","Homo Mimeticus: Theory and Criticism","€1,044,000","Mimesis is one of the most influential concepts in Western thought. Originally invoked to define humans as the “most imitative” creatures in classical antiquity, mimesis (imitation) has recently been at the centre of theoretical debates in the humanities, social sciences, and the neurosciences concerning the role of “mimicry,” “identification,” “contagion,” and “mirror neurons” in the formation of subjectivity. And yet, despite the growing confirmations that imitation is constitutive of human be",{"id":1040,"funder":7,"programme":8,"title":1041,"piName":10,"institution":1042,"country":145,"year":13,"amount":42,"abstract":1043},"cordis-european-research-council-award-679722","Dynamics and transport of quantum matter --- exploring the interplay of topology, interactions and localization","KUNGLIGA TEKNISKA HOEGSKOLAN","Quantum matter is condensed matter which properties are dominated by the quantum nature of its constituents. The two most fundamental properties of quantum mechanics are interference and entanglement. How do these properties, and their derivatives, show up in an experiment? And how does one control them? These are the fundamental questions addressed in this proposal.The study is divided into three main parts: many-body localization, topological insulator nanowires, and topological semimetals. Ma",{"id":1045,"funder":7,"programme":8,"title":1046,"piName":10,"institution":1047,"country":501,"year":13,"amount":1048,"abstract":1049},"cordis-european-research-council-award-680040","Cognitive Ageing in Dogs","EOTVOS LORAND TUDOMANYEGYETEM","€1,202,500","The aim of this project is to understand the causal factors contributing to the cognitive decline during senescence and to develop sensitive and standardized behaviour tests for early detection in order to increase the welfare of affected species. With the rapidly ageing population of Europe, related research is a priority in the European Union. We will focus both on characterising the ageing phenotype and the underlying biological processes in dogs as a well-established natural animal model. We",{"id":1051,"funder":7,"programme":8,"title":1052,"piName":10,"institution":1053,"country":113,"year":13,"amount":1054,"abstract":1055},"cordis-european-research-council-award-677786","Dynamic Penetrating Peptide Adaptamers","UNIVERSIDAD DE SANTIAGO DE COMPOSTELA","€1,492,525","The aim of this proposal is to identify, at the molecular level, the minimal topological and structural motifs that govern the membrane translocation of short peptides. A covalent reversible bond strategy will be developed for the synthesis of self-adaptive penetrating peptides (adaptamers) for targeted delivery.It is known that the recently developed therapeutic technologies (i.e. gene therapy, chemotherapy, hyperthermia, etc.) cannot reach their expected potential due to limitations in the cur",{"id":1057,"funder":7,"programme":8,"title":1058,"piName":10,"institution":157,"country":158,"year":13,"amount":1059,"abstract":1060},"cordis-european-research-council-award-677756","Forecasting Surface Weather and Climate at One-Month Leads through Stratosphere-Troposphere Coupling","€1,808,000","Anomalies in surface temperatures, winds, and precipitation can significantly alter energy supply and demand, cause flooding, and cripple transportation networks.  Better management of these impacts can be achieved by extending the duration of reliable predictions of the atmospheric circulation. Polar stratospheric variability can impact surface weather for well over a month, and this proposed research presents a novel approach towards understanding the fundamentals of how this coupling occurs. ",{"id":1062,"funder":7,"programme":8,"title":1063,"piName":10,"institution":1064,"country":48,"year":13,"amount":1065,"abstract":1066},"cordis-european-research-council-award-677823","Study of the interplay between CRISPR interference and DNA repair pathways towards the development of novel CRISPR tools","INSTITUT PASTEUR","€1,499,763","CRISPR-Cas loci are the adaptive immune system of archaea and bacteria. They can capture pieces of invading DNA and use this information to degrade target DNA through the action of RNA-guided nucleases. The consequences of DNA cleavage by Cas nucleases, i.e. how breaks are processed and whether they can be repaired, remains to be investigated.  A better understanding of the interplay between DNA repair and CRISPR-Cas is critical both to shed light on the evolution and biology of these fascinatin",{"id":1068,"funder":7,"programme":8,"title":1069,"piName":10,"institution":1070,"country":549,"year":13,"amount":1071,"abstract":1072},"cordis-european-research-council-award-679368","PRINCIPLES OF AXIAL POLARITY-DRIVEN VASCULAR PATTERNING","INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES","€1,618,750","The formation of a functional patterned vascular network is essential for development, tissue growth and organ physiology. Several human vascular disorders arise from the mis-patterning of blood vessels, such as arteriovenous malformations, aneurysms and diabetic retinopathy. Although blood flow is recognised as a stimulus for vascular patterning, very little is known about the molecular mechanisms that regulate endothelial cell behaviour in response to flow and promote vascular patterning. Rece",{"id":1074,"funder":7,"programme":8,"title":1075,"piName":10,"institution":1064,"country":48,"year":13,"amount":42,"abstract":1076},"cordis-european-research-council-award-679980","Regulation of cell size and shape in bacteria","Proper cell size and shape are important for many biological functions, such as metabolism, signaling, motility, and development. This proposal addresses the fundamental question of how bacteria control their morphology and their cell volume with high precision, using the rod-like bacterium Escherichia coli as a primary model system. Bacterial cell shape is physically determined during growth by the enzymatic expansion and remodeling of the peptidoglycan (PG) cell wall, a partially ordered elast",{"id":1078,"funder":7,"programme":8,"title":1079,"piName":10,"institution":157,"country":158,"year":13,"amount":42,"abstract":1080},"cordis-european-research-council-award-678977","Mechanobiology of Bovine Reproduction","The global demand for dairy products is expected to surge by 36% over the next decade in a manner that is progressively insatiable by existing technologies. The dairy industry relies on bovine reproduction, yet cow fertility is declining and the exact causes are not fully understood. It is clear, however, that the quality of bovine oocytes is decreasing. In mammals, the ovarian reserve of oocytes stored within quiescent primordial follicles is non-renewable. Oocyte develop and mature within dist",{"id":1082,"funder":7,"programme":8,"title":1083,"piName":10,"institution":1084,"country":41,"year":13,"amount":42,"abstract":1085},"cordis-european-research-council-award-679921","CHECKPOINTS IN CHECK: Novel Chemical Toolbox for Local Cancer Immunotherapy","STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM","Cancer evades the immune system by generating an immunosuppressive tumour-microenvironment through various mechanisms to enable unhampered growth. Recent breakthroughs in blocking one of these mechanisms – the so called ‘immune checkpoints’ – put cancer immunotherapy back in the spotlights. Although promising, clinical benefits of these checkpoint inhibitors as single treatment has been limited to a subset of patients and goes along with unwanted systemic autoimmune toxicity. I hypostasize, that",{"id":1087,"funder":7,"programme":8,"title":1088,"piName":10,"institution":1089,"country":120,"year":13,"amount":10,"abstract":1090},"cordis-european-research-council-award-679239","Self-Organization of the Bacterial Cell","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","One of the most remarkable features of biological systems is their ability to self-organize in space and time. Even a relatively simple cell like the bacterium Escherichia coli has a precisely regulated cellular anatomy, which emerges from dynamic interactions between proteins and the cell membrane. Self-organization allows the cell to perform extremely challenging tasks. 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