[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-starting-grant-2019":3,"awarded-stats-erc-starting-grant":1099},{"awarded":4,"total":1098},[5,16,21,26,33,38,43,48,53,59,64,71,78,82,87,93,100,104,108,113,120,125,130,136,142,146,152,157,162,169,175,180,186,191,195,202,207,211,216,221,228,233,238,242,249,255,262,268,272,278,285,290,295,300,305,310,315,320,325,331,337,343,348,355,360,366,372,378,384,390,397,403,408,414,419,425,431,438,444,450,455,461,466,472,478,485,491,497,502,508,513,518,523,528,535,541,547,551,556,561,567,572,578,583,588,593,598,602,607,612,617,623,628,634,640,646,653,660,666,671,676,682,687,693,698,704,710,715,720,726,731,735,740,746,751,756,761,765,771,777,781,786,790,795,799,805,809,816,821,826,832,838,843,849,855,860,866,872,877,882,887,893,899,904,909,915,920,925,930,936,940,945,951,956,962,966,971,976,981,986,992,998,1004,1010,1016,1021,1026,1031,1037,1042,1048,1053,1059,1064,1068,1073,1077,1083,1088,1093],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-802242","European Research Council","ERC Starting Grant","Drivers and consequences of coevolution in protective symbiosis",null,"THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","UK",2019,"€1,499,275","All organisms in nature are targets for parasite attack. Over a century ago, it was first observed that symbiotic species living in hosts can provide a strong barrier against infection, beyond the host’s own defence responses. We now know that ‘protective’ microbial symbiont species are key components of plant, animal, and human microbiota, shaping host health in the face of parasite infection. I have shown that microbes can evolve within days to protect, providing the possibility that microbe-m",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":11,"country":12,"year":13,"amount":19,"abstract":20},"cordis-european-research-council-award-852765","Optical interrogation of the claustrum from synapses to behavior","€1,500,000","How does the brain integrate inputs from the environment to generate perception and drive decisions? An enigmatic brain region called the claustrum has been suggested to play a role by integrating inputs from multiple brain regions. There is strong interconnectivity between claustrum and nearly every neocortical brain region, indicating that it exerts widespread influence on brain function. However, approaches to specifically record from or manipulate activity in the claustrum have been hindered",{"id":22,"funder":7,"programme":8,"title":23,"piName":10,"institution":11,"country":12,"year":13,"amount":24,"abstract":25},"cordis-european-research-council-award-802689","Optimal transport techniques in the geometric analysis of spaces with curvature bounds","€1,256,221","The unifying goal of the CURVATURE project is to develop new strategies and tools in order to attack fundamental questions in the theory of smooth and non-smooth spaces satisfying (mainly Ricci or sectional) curvature restrictions\u002Fbounds. The program involves analysis and geometry, with strong connections to probability and mathematical physics. The problems will be attacked by an innovative merging of geometric analysis and optimal transport techniques that already enabled the PI and collaborat",{"id":27,"funder":7,"programme":8,"title":28,"piName":10,"institution":29,"country":30,"year":13,"amount":31,"abstract":32},"cordis-european-research-council-award-805201","Regulation of bone metastases by age-associated angiocrine signals","UNIVERSIDADE DE COIMBRA","PT","€1,496,613","Blood vessels form a versatile transport network and provide inductive signals called angiocrine factors to regulate tissue-specific functions. Blood vessels in bone are heterogeneous with distinct capillary subtypes that exhibit remarkable alterations with age. Bone is the most prevalent site of metastasis, and ageing is linked to the reactivation of dormant tumor cells (dorTCs) and metastatic relapse. Bone remodeling processes are also associated with metastatic relapse. Here, I will define th",{"id":34,"funder":7,"programme":8,"title":35,"piName":10,"institution":11,"country":12,"year":13,"amount":36,"abstract":37},"cordis-european-research-council-award-805469","Deformation control on flow and transport in soft porous media","€1,482,862","Fluid flows through soft porous media are ubiquitous across nature and industry, from methane bubbles rising through lakebed and seabed sediments to nutrient transport in living cells and tissues to the manufacturing of paper products and many composites. Despite their ubiquity, flow and transport in these systems remain at the frontier of our ability to measure and model. A defining feature of soft porous media is that they can experience deformations that transform the pore structure. This has",{"id":39,"funder":7,"programme":8,"title":40,"piName":10,"institution":11,"country":12,"year":13,"amount":41,"abstract":42},"cordis-european-research-council-award-803763","China, Law, and Development","€1,499,381","The world is in the midst of a sea change in approaches to development. The rise of nationalist politics in the U.S., U.K. and Europe have questioned commitments to global governance at the same time that China has emerged as a champion of globalization, a turn of geo-political events that would have been unfathomable ten years ago. Through its own multi-lateral institutions, China is setting a new agenda for development from Europe to Oceania. China’s approach differs from Anglo\u002FEuro\u002FAmerican a",{"id":44,"funder":7,"programme":8,"title":45,"piName":10,"institution":11,"country":12,"year":13,"amount":46,"abstract":47},"cordis-european-research-council-award-802349","Silver and the Origins of the Viking Age","€1,499,830","This project will address one of the enduring questions of medieval studies - the origins of the Viking Age (c. 750-1050 AD) - through an interdisciplinary (archaeological, archaeometric and numismatic) study of silver from early Viking-Age Scandinavia.  In doing so, it will provide the first large-scale, systematic and empirically-based answers to the outstanding questions of where, when and why the Viking Age began, casting vital new light on what is widely recognised to be a pivotal episode o",{"id":49,"funder":7,"programme":8,"title":50,"piName":10,"institution":11,"country":12,"year":13,"amount":51,"abstract":52},"cordis-european-research-council-award-804213","Topological Matter and Crystal Symmetry: From Microscopic Structure to Phenomenology","€1,499,622","This ERC project will build a wide-ranging theory of strongly-correlated topological states of matter in three dimensions, via analytical, numerical, and phenomenological approaches. It will use non-symmorphic crystal symmetry as an organizing principle to identify systems that are good candidates to host fractionalized states of matter. Via slave-particle mean-field theories used in concert with symmetry analysis, it will provide a systematic classification of different possible spin-charge-sep",{"id":54,"funder":7,"programme":8,"title":55,"piName":10,"institution":56,"country":57,"year":13,"amount":41,"abstract":58},"cordis-european-research-council-award-803147","Radiocarbon, tree rings, and solar variability provide the accurate time scale for human evolution and geoscience","ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA","IT","Europe was the continent where Neanderthal and Anatomically Modern Human (AMH) interacted in a supposed time window of up to five millennia around 40,000 years ago (40 ka BP). The fate of our species versus the demise of Neanderthals, the geospatial timing of this process, the behavioural implications of their interaction, are hotly debated topics in archaeology. In this context, chronology plays a pivotal role, with radiocarbon (14C) dating representing the backbone back to 50 ka BP.However, du",{"id":60,"funder":7,"programme":8,"title":61,"piName":10,"institution":56,"country":57,"year":13,"amount":62,"abstract":63},"cordis-european-research-council-award-802362","Bottom-up initiatives and anti-corruption technologies: how citizens use ICTs to fight corruption","€1,489,115","Corruption is a global challenge that affects the lives of millions of citizens. In the past decade, Information and Communication Technologies (ICTs) have become indispensable tools in the fight to reduce corruption, especially when employed from the bottom-up by civil society organizations. While pioneering initiatives in this direction have flourished, to date we only have unsystematic and descriptive evidence regarding how they work and the associated consequences. With the objective of sign",{"id":65,"funder":7,"programme":8,"title":66,"piName":10,"institution":67,"country":68,"year":13,"amount":69,"abstract":70},"cordis-european-research-council-award-802512","Design Global, Manufacture Local: Assessing the Practices, Innovation, and Sustainability Potential of an Emerging Mode of Production","TALLINNA TEHNIKAÜLIKOOL","EE","€1,017,275","COSMOLOCALISM will document, analyse, test, evaluate, and create awareness about an emerging mode of production, based on the confluence of the digital commons (e.g. open knowledge and design) with local manufacturing and automation technologies (from 3D printing and CNC machines to low-tech tools and crafts). This convergence could catalyse the transition to new inclusive and circular productive models, such as the “design global, manufacture local” (DGML) model.DGML describes the processes thr",{"id":72,"funder":7,"programme":8,"title":73,"piName":10,"institution":74,"country":75,"year":13,"amount":76,"abstract":77},"cordis-european-research-council-award-802041","Nociception and sensory nerves as regulators of type 2 immunity and skin inflammation","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","FR","€1,497,441","Preserving skin homeostasis depends on complex interactions among structural cells, immune cells, and the environment. Dysregulation of this delicate equilibrium contributes to the development of type 2 immunity-associated skin inflammation (i.e., allergic skin inflammation), including atopic dermatitis (AD). The skin is a complex organ harboring various tissue-resident immune cells (e.g., dendritic cells, mast cells and macrophages) and innervated by a meshwork of sensory nerves, including thos",{"id":79,"funder":7,"programme":8,"title":80,"piName":10,"institution":74,"country":75,"year":13,"amount":19,"abstract":81},"cordis-european-research-council-award-803704","Regulation of synaptic development and plasticity by molecular pathways linked to human evolution","The synapse is a nanoscale machine, which transfers, integrates and stores information in brain circuits. Its function relies on multimolecular networks of interactions whose composition and dynamics shape synaptic transmission. A large body of evidence indicates that synapses specialized in humans. Human synapses are more densely distributed along dendrites and their period of maturation is protracted compared to rodent or non-human primate synapses. The rules governing their plasticity also di",{"id":83,"funder":7,"programme":8,"title":84,"piName":10,"institution":74,"country":75,"year":13,"amount":85,"abstract":86},"cordis-european-research-council-award-805500","Assessing the role of ribosomes and mRNA translation in shaping the inflammatory response","€1,499,720","Inflammation is a highly regulated process that acts as a first line of defense against pathogens infections. Triggered by cellular pattern recognition receptors (PRRs) that recognize specific microbial components and endogenous or exogenous non-microbial components, activation of inflammation induces a dynamic and coordinated gene expression program that leads to the production of cytokines and chemokines to attract effector cells to the site of infection. Although a robust inflammatory respons",{"id":88,"funder":7,"programme":8,"title":89,"piName":10,"institution":90,"country":57,"year":13,"amount":91,"abstract":92},"cordis-european-research-council-award-801715","Biomarkers of individual differences in human cortical visual processing","UNIVERSITA DI PISA","€1,490,375","Vision is probably the best understood system of the human brain: studying vision has taught us much about the human mind and its complex processes. We know in detail the fundamental steps leading to visual perception, but we do not know why normally sighted people differ in how they perceive: why some “see the forest before the trees”, while others have a fragmented perceptual experience focused on local features. PUPILTRAITS aims to fill this gap by taking an innovative approach to vision scie",{"id":94,"funder":7,"programme":8,"title":95,"piName":10,"institution":96,"country":97,"year":13,"amount":98,"abstract":99},"cordis-european-research-council-award-801434","Coding for Security and DNA Storage","TECHNISCHE UNIVERSITAET MUENCHEN","DE","€1,471,750","Communication and data storage systems are indispensable parts of our every-day life. However, these systems deal with severe challenges in security and reliability. Security is important whenever a user communicates or stores sensitive data, e.g., medical information; reliability has to be guaranteed to be able to transmit or store information while noise occurs. Algebraic codes (ACs) are a powerful means to achieve both.Within inCREASE, I will construct and evaluate special codes for security ",{"id":101,"funder":7,"programme":8,"title":102,"piName":10,"institution":96,"country":97,"year":13,"amount":19,"abstract":103},"cordis-european-research-council-award-804724","Scan2CAD: Learning to Digitize the Real World","One of the most fundamental challenges in the digital age is to automatically create accurate, high-quality 3D representations of the world around us. This would have far-reaching impact, from enabling advances entertainment and immersive technologies (e.g., mixed reality) to medical applications and industrial manufacturing pipelines. Despite remarkable progress in scanning devices and 3D reconstruction algorithms, the resulting models remain highly impractical for display or use in virtual env",{"id":105,"funder":7,"programme":8,"title":106,"piName":10,"institution":96,"country":97,"year":13,"amount":19,"abstract":107},"cordis-european-research-council-award-804098","Challenges on the road to genome duplication:  Single-molecule approaches to study replisome collisions","Faithful duplication and transmission of genetic and epigenetic information is the most vital cellularfunction for the preservation and proliferation of life. In cells, this process is conducted by largemacromolecular complexes, known as replisomes, that coordinate the sequence of enzymatic eventsduring chromosome duplication. While recently developed single-molecule techniques promiseunprecedented access to the complex inner workings of these sophisticated machines, most studiesconducted have f",{"id":109,"funder":7,"programme":8,"title":110,"piName":10,"institution":96,"country":97,"year":13,"amount":111,"abstract":112},"cordis-european-research-council-award-804228","Exploring coherent neutrino-nucleus scattering with gram-scale cryogenic calorimeters","€1,642,500","-cleus will be a new multi-purpose table-top experiment aimed at the first exploration of coherent neutrino-nucleus scattering (CNNS) at a nuclear power reactor. Our novel detector technology will achieve an unprecedentedly high sensitivity to new physics within and beyond the Standard Model of Particle Physics, with an enormous discovery potential. The new method is not only complementary to competing approaches, but superior in terms of performance, cost and size. The ultra-low threshold chara",{"id":114,"funder":7,"programme":8,"title":115,"piName":10,"institution":116,"country":117,"year":13,"amount":118,"abstract":119},"cordis-european-research-council-award-803096","Secure, Private, Efficient Multiparty Computation","AARHUS UNIVERSITET","DK","€1,495,902","MPC is a cryptographic technique that allows a set of mutually distrusting parties to compute any joint function of their private inputs in a way that preserves the confidentiality of the inputs and the correctness of the result. Examples of MPC applications include secure auctions, benchmarking, privacy-preserving data mining, etc.In the last decade, the efficiency of MPC has improved significantly, especially with respect to evaluating functions expressed as Boolean and arithmetic circuits. Th",{"id":121,"funder":7,"programme":8,"title":122,"piName":10,"institution":116,"country":117,"year":13,"amount":123,"abstract":124},"cordis-european-research-council-award-804418","Inflammatory resolution and remodelling of the adipose extracellular matrix: key determinants of a metabolically healthy phenotype?","€1,700,002","Obesity and its affiliated metabolic diseases pose serious public-health challenges. However, certain patient subgroups appear protected. To halt the socio-economic burden of metabolic disease, we urgently need to understand what distinguishes the Metabolically-Healthy-Lean (MHL), Metabolically-Unhealthy-Lean (MUL), Metabolically-Healthy-Obese (MHO) and Metabolically-Unhealthy-Obese (MUO) phenotypes, and which factors promote metabolic health. Inflammation has been proposed as a target, as it is",{"id":126,"funder":7,"programme":8,"title":127,"piName":10,"institution":116,"country":117,"year":13,"amount":128,"abstract":129},"cordis-european-research-council-award-802244","The Psychology of Administrative Burden","€1,499,611","The burdens of dealing with administrative rules and red tape in government are a fact of life around the world, ranging from small hassles to heavy burdens in the form of stigmatizing processes of proving eligibility and facing potential sanctions. In light of the immense importance of such burdens for millions of people and for the effectiveness of benefit programs, we know surprisingly little about the conditions that give rise to experiences of burden. POAB combines and extends extant theory",{"id":131,"funder":7,"programme":8,"title":132,"piName":10,"institution":133,"country":75,"year":13,"amount":134,"abstract":135},"cordis-european-research-council-award-803721","Finding how Earthquakes And Storms Impact the Building of Landscapes","UNIVERSITE DE RENNES","€1,498,829","Unravelling how tectonics, climate and surface processes act and interact to shape the Earth’s surface is one of the most challenging unresolved issue in Earth Sciences. The foundations of modern quantitative geomorphology have been built within the paradigm of steady-state landscapes responding to slow changes in climatic or tectonic conditions, mainly rainfall or uplift rate. Yet, recent results demonstrate that landscapes are rhythmed by (potentially extreme) storms and earthquakes. These per",{"id":137,"funder":7,"programme":8,"title":138,"piName":10,"institution":139,"country":75,"year":13,"amount":140,"abstract":141},"cordis-european-research-council-award-804023","Dynamics of modified chromatin domains","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€1,447,860","Cellular identity is defined by complex patterns of DNA and histone modifications, which partition our chromosomes and determine how cells interpret the genetic information. For cells to remember who they are, these modifications have to be tightly regulated over time and through cell division. Loss of cellular identity promotes different types of disease including neurological disorders and cancer.Histone modifications can spread along chromatin and can be transmitted through cell division, giv",{"id":143,"funder":7,"programme":8,"title":144,"piName":10,"institution":139,"country":75,"year":13,"amount":19,"abstract":145},"cordis-european-research-council-award-804144","The asymmetry of life: towards a unified view of the emergence of biological homochirality","What is responsible for the emergence of homochirality, the almost exclusive use of one enantiomer over its mirror image? And what led to the evolution of life’s homochiral biopolymers, DNA\u002FRNA, proteins and lipids, where all the constituent monomers exhibit the same handedness? Based on in-situ observations and laboratory studies, we propose that this handedness occurs when chiral biomolecules are synthesized asymmetrically through interaction with circularly polarized photons in interstellar s",{"id":147,"funder":7,"programme":8,"title":148,"piName":10,"institution":149,"country":97,"year":13,"amount":150,"abstract":151},"cordis-european-research-council-award-801708","Anticipatory Human-Computer Interaction","UNIVERSITY OF STUTTGART","€1,499,625","Even after three decades of research on human-computer interaction (HCI), current general-purpose user interfaces (UI) still lack the ability to attribute mental states to their users, i.e. they fail to understand users' intentions and needs and to anticipate their actions. This drastically restricts their interactive capabilities.ANTICIPATE aims to establish the scientific foundations for a new generation of user interfaces that pro-actively adapt to users' future input actions by monitoring th",{"id":153,"funder":7,"programme":8,"title":154,"piName":10,"institution":155,"country":97,"year":13,"amount":19,"abstract":156},"cordis-european-research-council-award-853489","Deeply Explainable Intelligent Machines","HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH","Explanations are valuable because they scaffold the kind of learning that supports adaptive behaviour, e.g. explanations enable users to adapt themselves to the situations that are about to arise. Explanations allow us to attain a stable environment and have the possibility to control it, e.g. explanations put us in a better position to control the future. Explanations in the medical domain can help patients identify and monitor the abnormal behaviour of their ailment. In the domain of self-driv",{"id":158,"funder":7,"programme":8,"title":159,"piName":10,"institution":155,"country":97,"year":13,"amount":160,"abstract":161},"cordis-european-research-council-award-803077","Bacteriophage inhibition of antibiotic-resistant pathogenic microbes and founding for novel therapeutic strategies","€1,499,650","Emergence of antimicrobial resistance (AMR) is a grand scientific challenge of our time that has killed more than 700,000 people worldwide.  Phage therapy, a promising complement to antibiotics, utilizes viruses of bacteria (bacteriophages) or phage-derived inhibitors as natural ways to fight AMR.  The main obstacles in the clinical application of phage-based AMR therapy are the limited number of phage isolates and the unknown molecular mechanisms of phage-delivered bactericidal action.  Buildin",{"id":163,"funder":7,"programme":8,"title":164,"piName":10,"institution":165,"country":166,"year":13,"amount":167,"abstract":168},"cordis-european-research-council-award-803506","The Rise and Fall of Populism and Extremism","UNIVERSIDAD POMPEU FABRA","ES","€1,467,736","In the recent years in advanced democracies there has been a wave of electoral successes of populist politicians supporting extreme messages. Is populism caused by negative economic shocks? If so, what are the mechanisms? What explains heterogeneity in responses to such shocks? In this project, I will test empirically if personal experiences, information environment, and their interaction with aggregate economic shocks shape people’s political decisions. The project consists of three parts.First",{"id":170,"funder":7,"programme":8,"title":171,"piName":10,"institution":172,"country":97,"year":13,"amount":173,"abstract":174},"cordis-european-research-council-award-802729","Digital Radio Detectors for Galactic PeV Particles","KARLSRUHER INSTITUT FUER TECHNOLOGIE","€1,629,541","The most energetic particles in our Galaxy are accelerated by yet unknown sources to energies much beyond the reach of human-made accelerators such as LHC at CERN. The detection of PeV photons from such a natural Galactic accelerator will be a fundamental breakthrough. For this purpose I propose a digital radio array for air showers at South Pole building on my proven expertise in successfully setting up and managing an antenna array in Siberia. Recently, we have discovered that by using higher ",{"id":176,"funder":7,"programme":8,"title":177,"piName":10,"institution":172,"country":97,"year":13,"amount":178,"abstract":179},"cordis-european-research-council-award-853619","Genetically enhanced, optically superior tissues (GHOSTS)","€1,496,994","Most biological tissues are optically opaque, largely precluding access by light microscopy. In stark contrast, some living tissues and organisms are highly transparent. Examples include many deep-sea fish, your retina, and cells that we exposed to directed evolution.Here we propose to uncover the genetic basis of tissue transparency, such that living cells and tissue cultures can be optically cleared by precision genetics. For this we will combine insights into origins of retina transparency, a",{"id":181,"funder":7,"programme":8,"title":182,"piName":10,"institution":183,"country":166,"year":13,"amount":184,"abstract":185},"cordis-european-research-council-award-801809","predictinG EaRthquakES induced by fluid injecTion","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","€1,438,201","Fluid injection related to underground resources has become widespread, causing numerous cases of induced seismicity. If felt, induced seismicity has a negative effect on public perception and may jeopardise wellbore stability, which has led to the cancellation of several projects. Forecasting injection-induced earthquakes is a big challenge that must be overcome to deploy geo-energies to significantly reduce CO2 emissions and thus mitigate climate change and reduce related health issues. The ba",{"id":187,"funder":7,"programme":8,"title":188,"piName":10,"institution":11,"country":12,"year":13,"amount":189,"abstract":190},"cordis-european-research-council-award-804394","Highest Precision QCD predictions for a new era in Higgs boson phenomenology","€1,497,016","The discovery of the Higgs boson at the CERN Large Hadron Collider (LHC) marked the beginning of a new era for particle physics. For the first time, we may have an experimentally tested and theoretically coherent picture of fundamental interactions, valid up to very high energies. A thorough exploration of the Higgs sector, to ascertain whether or not the new particle behaves as predicted by the Standard Model is now paramount.Such an investigation is extremely challenging, and it requires absol",{"id":192,"funder":7,"programme":8,"title":193,"piName":10,"institution":11,"country":12,"year":13,"amount":19,"abstract":194},"cordis-european-research-council-award-805445","High definition and time-resolved studies of exoplanet atmospheres: a new window on the extreme diversity of the exoplanet zoo","The ongoing search for a second Earth has revealed an astounding diversity in the population of planets orbiting other stars. This eclectic zoo of other worlds shows little similarity with our own solar system. The key to understanding this diversity lies in exoplanet atmospheres, which hold vital information on their formation histories and evolutionary pathways. To access them, I propose three ambitious new windows into exoplanet characterization that will: i) Deliver the largest homogenous st",{"id":196,"funder":7,"programme":8,"title":197,"piName":10,"institution":198,"country":199,"year":13,"amount":200,"abstract":201},"cordis-european-research-council-award-805041","organisation of CLoUdS, and implications for Tropical cyclones and for the Energetics of the tropics, in current and in a waRming climate","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","AT","€1,078,021","Few geophysical phenomena are as spectacular as tropical cyclones, with their eye surrounded by sharp cloudy eyewalls. There are other types of spatially organised convection (convection refers to overturning of air within which clouds are embedded), in fact organised convection is ubiquitous in the tropics. But it is still poorly understood and poorly represented in convective parameterisations of global climate models, despite its strong societal and climatic impact. It is associated with extr",{"id":203,"funder":7,"programme":8,"title":204,"piName":10,"institution":139,"country":75,"year":13,"amount":205,"abstract":206},"cordis-european-research-council-award-803079","Probing new physics with Coherent Elastic Neutrino-Nucleus  Scattering and a tabletop experiment","€1,495,000","Ever since the Higgs boson was discovered at the LHC in 2012, we had the confirmation that the Standard Model (SM) of particle physics has to be extended. In parallel, the long lasting Dark Matter (DM) problem, supported by a wealth of evidence ranging from precision cosmology to local astrophysical observations, has been suggesting that new particles should exist. Unfortunately, neither the LHC nor the DM dedicated experiments have significantly detected any exotic signals pointing toward a par",{"id":208,"funder":7,"programme":8,"title":209,"piName":10,"institution":139,"country":75,"year":13,"amount":10,"abstract":210},"cordis-european-research-council-award-803208","Violence, State formation and memory politics: an off-site ethnography of post-revolution Iran","How can violence be studied when access to the field is impossible? Fieldwork is a trademark of ethnography, which is fast becoming a key practice in qualitative research across disciplines. In conflict and post-conflict zones, social scientists tend to negotiate access to fieldwork through an international community of experts and practitioners. But empirical investigation proves more difficult in strong regimes that are closed or restricted, and exert (tight) surveillance over academics and th",{"id":212,"funder":7,"programme":8,"title":213,"piName":10,"institution":139,"country":75,"year":13,"amount":214,"abstract":215},"cordis-european-research-council-award-804320","DESIGNING 2D NANOSHEETS FOR CO2 REDUCTION AND INTEGRATION INTO vdW HETEROSTRUCTURES FOR ARTIFICIAL PHOTOSYNTHESIS","€1,499,931","CO2 reduction reaction (CO2RR) holds great promise for conversion of the green-house gas carbon dioxide into chemical fuels. The absence of catalytic materials demonstrating high performance and high selectivity currently hampers practical demonstration. CO2RR is also limited by the low solubility of CO2 in the electrolyte solution and therefore electrocatalytic reactions in gas phase using gas diffusion electrodes would be preferred. 2D materials have recently emerged as a novel class of electr",{"id":217,"funder":7,"programme":8,"title":218,"piName":10,"institution":139,"country":75,"year":13,"amount":219,"abstract":220},"cordis-european-research-council-award-803676","Understanding the onset and impact of Aquatic Resource Consumption in Human Evolution using novel Isotopic tracerS","€1,361,991","The onset of the systematic consumption of marine resources is thought to mark a turning point for the hominin lineage. To date, this onset cannot be traced, since classic isotope markers are not preserved beyond 50 - 100 ky. Aquatic food products are essential in human nutrition as the main source of polyunsaturated fatty acids in hunter-gatherer diets. The exploitation of marine resources is also thought to have reduced human mobility and enhanced social and technological complexification. Sys",{"id":222,"funder":7,"programme":8,"title":223,"piName":10,"institution":224,"country":225,"year":13,"amount":226,"abstract":227},"cordis-european-research-council-award-802998","Brains and minds in transition: The dark side of neuroplasticity during sensitive life phases","UNIVERSITETET I OSLO","NO","€1,446,113","The potential and boundaries of the human mind is determined by dynamic interactions between the environment and the individual genetic architecture. However, despite several breakthroughs, the genetic revolution has not provided a coherent account of the development of the mind and its disorders, and the missing heritability is large across human traits. One explanation of this impasse is the complexity of the gene-environment interactions. Current knowledge about the determinants of a healthy ",{"id":229,"funder":7,"programme":8,"title":230,"piName":10,"institution":224,"country":225,"year":13,"amount":231,"abstract":232},"cordis-european-research-council-award-803211","Whales of Power: Aquatic Mammals, Devotional Practices, and Environmental Change in Maritime East Asia","€1,499,819","In various parts of East Asia, aquatic mammals are associated with divine power, and serve as objects of devotion. In south and central Vietnam, cetaceans are worshipped as life-saving deities. In some Japanese coastal areas, the spirits of whales are venerated during ritual ceremonies. In China, Cambodia and the Ryukyu Islands, aquatic mammals have all been associated with water deities. These animals continue to carry significant symbolic capital today – if no longer as gods, at least as local",{"id":234,"funder":7,"programme":8,"title":235,"piName":10,"institution":224,"country":225,"year":13,"amount":236,"abstract":237},"cordis-european-research-council-award-802070","Brokering China’s Extraversion: An Ethnographic Analysis of Transnational Arbitration","€1,490,773","Chinese global engagements are deepening across sectors and geographic regions. The objective of BROKEX is to fill specific gaps in knowledge about how China’s extraversion advances. The project takes an original approach by examining brokers who mediate in transnational fields. It opens the “black box” of China’s global integration by moving beyond descriptions of input and output characteristics to elucidate underlying dynamics. The objective will be achieved in two phases. First, the PI and t",{"id":239,"funder":7,"programme":8,"title":240,"piName":10,"institution":224,"country":225,"year":13,"amount":19,"abstract":241},"cordis-european-research-council-award-802885","How distress alters opioid drug effects and abuse liability","As the opioid epidemic escalates, we must ask: why are opioids so addictive? Non-human animal research links addiction with the powerful relief opioids can offer to animals in distress. In humans, epidemiological and clinical studies converge upon social stressors and a poor social support network as key risk factors for addiction. Despite this, it is currently unknown how pre-drug distress might alter opioid drug effects. Tremendous resources are dedicated to charting how people feel after taki",{"id":243,"funder":7,"programme":8,"title":244,"piName":10,"institution":245,"country":246,"year":13,"amount":247,"abstract":248},"cordis-european-research-council-award-804104","Value Judgments and Redistribution Policies","UNIVERSITAET ST. GALLEN","CH","€1,033,771","Heterogeneity and diversity are a pervasive aspect of modern societies. Differences in individuals’ preferences, needs, skills, and information are key to explain variation in individuals’ behavior and to anticipate individuals’ responses to policy changes. There is no consensus, however, about how to take these differences into account when evaluating policies.Project VALURED will reexamine this ethical challenge by characterizing the mapping between value judgments—i.e. principles of distribut",{"id":250,"funder":7,"programme":8,"title":251,"piName":10,"institution":252,"country":57,"year":13,"amount":253,"abstract":254},"cordis-european-research-council-award-804240","NEar FiEld cosmology: Re-Tracing Invisible TImes","UNIVERSITA DEGLI STUDI DI FIRENZE","€1,180,813","The goal of NEFERTITI is to make a major step forward in our understanding of the first stars and galaxies by catching the stellar fossils from the early Universe in our Galactic neighborhood. To move beyond the state-of-the-art and study many of these precious fossils, I will adopt a novel approach that integrates theoretical and observational research and that will allow me to fully exploit: i) the huge data-flow from upcoming stellar surveys, ii) my cosmological models, which uniquely link Lo",{"id":256,"funder":7,"programme":8,"title":257,"piName":10,"institution":258,"country":259,"year":13,"amount":260,"abstract":261},"cordis-european-research-council-award-803051","Just because we can, should we? An anthropological perspective on the initiation of technology dependence to sustain a child’s life","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","IE","€1,464,101","There is an increasing number of children with complex healthcare needs who require continuous technological support to sustain their lives. This technology dependence is initiated in an environment of medical interventionism, with potential for discrete discrimination. A scarcity of empirical data on the influences and interactions at the point of the initiation of technology dependence means that clinical, legal and ethical deliberations are driven more by opinion than empirical evidence. An e",{"id":263,"funder":7,"programme":8,"title":264,"piName":10,"institution":265,"country":259,"year":13,"amount":266,"abstract":267},"cordis-european-research-council-award-803486","Food, Culture and Identity in Ireland, 1550-1650","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","€1,433,133","FOODCULT is the first project to establish both the fundamentals of everyday diet, and the cultural ‘meaning’ of food and drink, in early modern Ireland. Exploring the period 1550-1650, one of major economic development, unprecedented intercultural contact, but also of conquest, colonisation and war, it focusses on Ireland as a case-study for understanding the role of food in the demonstration and negotiation of authority and power, and as a site for the development of emergent ‘national’ food c",{"id":269,"funder":7,"programme":8,"title":270,"piName":10,"institution":265,"country":259,"year":13,"amount":10,"abstract":271},"cordis-european-research-council-award-758887","REsponsive theranostic nanosystems for Advanced Cancer Treatment","REACT aims to dramatically impact the targeted release of diagnostic agents and drugs with nanomedicines that respond to biological cues or changing pathophysiological conditions, thus enabling ultrasensitive diagnosis and exquisite therapy selectivity. Nanomedicine research against cancer focuses on the local targeted delivery of chemotherapeutics to enhance drug efficacy and reduce side effects. Despite all the efforts in the design of chemotherapeutic agents as nanomedicines, hardly any impro",{"id":273,"funder":7,"programme":8,"title":274,"piName":10,"institution":275,"country":117,"year":13,"amount":276,"abstract":277},"cordis-european-research-council-award-801790","Improving health in people with multimorbidity: a paradigm shift in health care from disease-based curative models to personalized exercise therapy and self-management","SYDDANSK UNIVERSITET","€1,499,230","The  goal of this proposal is to support the paradigm shift in the health care of people with multiple chronic conditions in Europe from a focus on disease-based curative models to holistic person-centered self-care through personalized,supervised exercise therapy and education.The problem:The impact of multimorbidity on the individual and society is massive and much greater than the impact of single chronic conditions alone. However, effective treatments are missing and research and health care",{"id":279,"funder":7,"programme":8,"title":280,"piName":10,"institution":281,"country":282,"year":13,"amount":283,"abstract":284},"cordis-european-research-council-award-804907","Teaching Robots Interactively","TECHNISCHE UNIVERSITEIT DELFT","NL","€1,499,894","Programming and re-programming robots is extremely time-consuming and expensive, which presents a major bottleneck for new industrial, agricultural, care, and household robot applications. My goal is to realize a scientific breakthrough in enabling robots to learn how to perform manipulation tasks from few human demonstrations, based on novel interactive machine learning techniques.Current robot learning approaches focus either on imitation learning (mimicking the teacher’s movement) or on reinf",{"id":286,"funder":7,"programme":8,"title":287,"piName":10,"institution":281,"country":282,"year":13,"amount":288,"abstract":289},"cordis-european-research-council-award-804469","Concepts, theories and models for planning , operating and evaluating the dynamics of Mobility as a Service","€1,443,250","Online marketplaces enable in the travel context the dynamic matching of supply and demand. The shared economy can revolutionize urban mobility by blurring the traditional division between private and public transport, shifting from an ownership model to Mobility as a Service (MaaS).Existing transport models are designed with the premise that transport consists of either fully scheduled and controlled fleets or individual privately owned vehicles. Since MaaS breaks the conventional division betw",{"id":291,"funder":7,"programme":8,"title":292,"piName":10,"institution":281,"country":282,"year":13,"amount":293,"abstract":294},"cordis-european-research-council-award-850641","Quantum information transfer  between hole spins and topological states","€1,873,285","The promise of universal quantum computation stems from the remarkable behaviour of quantum states and the challenge is to gain control over their fragile nature. In topological quantum computation, information can be encoded nonlocally on Majorana states to provide inherent protection against noise, but operation is restricted to the trivial Clifford group. Spins in quantum dots do provide universal logic, but interactions are short-ranged. I propose to study the question whether these platform",{"id":296,"funder":7,"programme":8,"title":297,"piName":10,"institution":281,"country":282,"year":13,"amount":298,"abstract":299},"cordis-european-research-council-award-804151","Ancient Adhesives - A window on prehistoric technological complexity","€1,499,926","AncientAdhesives addresses the most crucial problem in Palaeolithic archaeology: How to reliably infer cognitively complex behaviour in the deep past. To study the evolution of Neandertal and modern human cognitive capacities, certain find categories are taken to reflect behavioural and thus cognitive complexitye.g. Among these are art objects, personal ornaments and complex technology. Of these technology is best-suited to trace changing behavioural complexity, because 1) it is the least vulner",{"id":301,"funder":7,"programme":8,"title":302,"piName":10,"institution":281,"country":282,"year":13,"amount":303,"abstract":304},"cordis-european-research-council-award-802348","Game theoretic Control for Complex Systems of Systems","€1,499,415","Modern society is based on large-scale, interconnected, complex infrastructures, e.g. power, transportation and communication systems, with network structure and interacting subsystems controlled by autonomous components and human users, generically called “agents”. These systems possess the features of “complex” systems of systems (C-SoS), such as rationality and autonomy of the agents, and require effective multi-agent coordination and control actions for their safe and efficient operation. Mu",{"id":306,"funder":7,"programme":8,"title":307,"piName":10,"institution":281,"country":282,"year":13,"amount":308,"abstract":309},"cordis-european-research-council-award-805021","Living on the Edge: Tunable Electronics from Edge Structures in 1D Layered Materials","€1,499,475","One of the driving forces of the ongoing nanotechnology revolution is the ever-improving ability to understand and control the properties of quantum matter even down to the atomic scale. Key drivers of this revolution are layered materials like transition metal dichalcogenides (TMD). The realisation of novel TMD-based electronic devices relies heavily on understanding the relation between structural and electrical properties at the nanoscale. Crucially, one-dimensional (1D) TMDs have been predic",{"id":311,"funder":7,"programme":8,"title":312,"piName":10,"institution":281,"country":282,"year":13,"amount":313,"abstract":314},"cordis-european-research-council-award-850818","Multiphoton Voltage Imaging","€1,499,655","Understanding the brain is one of the great scientific challenges of our time. This pursuit fundamentally depends on advances in physical sciences and engineering to provide novel tools and methods to perturb, record and interpret brain activity.Information in the brain is encoded in changes in the voltage across the membrane of brain cells. Voltage imaging with genetically encoded voltage indicators (GEVIs) is a revolutionary method that allows faithful recording of the fast electrical dynamics",{"id":316,"funder":7,"programme":8,"title":317,"piName":10,"institution":281,"country":282,"year":13,"amount":318,"abstract":319},"cordis-european-research-council-award-852410","A quantum network for distributed quantum computation","€1,499,910","A key question for quantum science is: Can quantum systems be protected from decoherence? This is not just a fundamental question; if we can reliably control large quantum states, it becomes possible to perform precise tests of quantum mechanics and computational tasks that go beyond classical physics.A promising approach is to protect quantum states by distributing quantum error correction over quantum networks. These networks consist of nodes that contain quantum bits to store and process quan",{"id":321,"funder":7,"programme":8,"title":322,"piName":10,"institution":323,"country":97,"year":13,"amount":19,"abstract":324},"cordis-european-research-council-award-853387","Phase map of dynamic, adaptive colloidal crystals far from equilibrium","RUHR-UNIVERSITAET BOCHUM","We recently reported the first observation of dynamic adaptive colloidal crystals exhibiting characteristics similar to those commonly associated with living organisms: self-replication, self-healing, adaptation, competition, motility. Here, I propose to do the first experiments to clarify precisely how dynamic adaptive behavior arises far from equilibrium and how to control it. The key to both is a fundamental question at the heart of condensed matter, statistical and nonlinear physics: When fa",{"id":326,"funder":7,"programme":8,"title":327,"piName":10,"institution":328,"country":282,"year":13,"amount":329,"abstract":330},"cordis-european-research-council-award-802615","Brain-Inspired Organic Modular Lab-on-a-Chip for Cell Classification","TECHNISCHE UNIVERSITEIT EINDHOVEN","€1,498,726","Brain-inspired (neuromorphic) computing has recently demonstrated advancements in pattern and image recognition as well as classification of unstructured (big) data. However, the volatility and energy required for neuromorphic devices presented to date significantly complicate the path to achieve the interconnectivity and efficiency of the brain. In previous work, recently published in Nature Materials, the PI has demonstrated a low-cost solution to these drawbacks: an organic artificial synapse",{"id":332,"funder":7,"programme":8,"title":333,"piName":10,"institution":334,"country":246,"year":13,"amount":335,"abstract":336},"cordis-european-research-council-award-853309","Acousto-Magnetic Micro\u002FNanorobots for Biomedical Applications","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","€1,484,839","Micro\u002Fnanorobots can transform many aspects of medicine by enabling tasks, such as delivering drugs or genes precisely to targeted areas, transducing force on individual cells or tissues, performing biopsies, and facilitating non-invasive surgeries. Numerous propulsion mechanisms have been developed, but their low propulsion speed, lack of biocompatibility, and poor navigation capabilities have limited their use. The objective of this proposal is to develop wireless micro\u002Fnanorobots using acoust",{"id":338,"funder":7,"programme":8,"title":339,"piName":10,"institution":340,"country":12,"year":13,"amount":341,"abstract":342},"cordis-european-research-council-award-803553","Simulations for Inertial Particle Microfluidics","THE UNIVERSITY OF EDINBURGH","€1,499,290","Cancer and bacterial infections are projected to kill 18 million people worldwide annually by 2050. Fast and reliable diagnostics are essential for early and targeted treatments. Microfluidics is at the heart of the miniaturisation of diagnostics, enabling novel portable and low-cost point-of-care devices. Inertial particle microfluidics (IPMF) is a novel and competitive method with applications in cancer cell and bacteria separation. Yet, the physics behind IPMF is not well understood, making p",{"id":344,"funder":7,"programme":8,"title":345,"piName":10,"institution":346,"country":282,"year":13,"amount":19,"abstract":347},"cordis-european-research-council-award-803035","Modelling the neuromusculoskeletal system across spatiotemporal scales for a new paradigm of human-machine motor interaction","UNIVERSITEIT TWENTE","Neurological injuries such as stroke leave millions of people disabled worldwide every year. For these individuals motor recovery is often suboptimal. The impact of current neurorehabilitation machines is hampered by limited knowledge of their physical interaction with the human. As we move, our body adapts positively to optimal stimuli; motor improvement after stoke is promoted via physical training with an appropriate afferent input to the nervous system and mechanical loads to muscles. Loss o",{"id":349,"funder":7,"programme":8,"title":350,"piName":10,"institution":351,"country":352,"year":13,"amount":353,"abstract":354},"cordis-european-research-council-award-850638","B Cell Immunodominance in Antiviral Immunity","GOETEBORGS UNIVERSITET","SE","€1,481,697","This proposal aims at understanding how B cell specificity and immunodominance shape primary and secondary humoral responses to influenza A virus. Influenza A virus is a relevant human pathogen causing a considerable yearly death toll and economic burden to society. Immunodominance is a major driving force of adaptive immunity and defines the hierarchical recognition of epitopes on the same antigen. Previous studies analysing B cell dynamics in primary and secondary responses have been mainly fo",{"id":356,"funder":7,"programme":8,"title":357,"piName":10,"institution":198,"country":199,"year":13,"amount":358,"abstract":359},"cordis-european-research-council-award-802960","Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines","€1,424,574","A key challenge in biological and soft-matter physics is to identify the principles that govern the organisation and functionality in non-equilibrium systems. Living systems are by definition out of equilibrium and a constant energy input is required to assemble and disassemble the molecular machinery of life. Only out of equilibrium, can proteins assemble to form functional sub-cellular structures, bind cells into dynamic tissues, and form complex biological machines. Our understanding of the p",{"id":361,"funder":7,"programme":8,"title":362,"piName":10,"institution":363,"country":282,"year":13,"amount":364,"abstract":365},"cordis-european-research-council-award-852069","The nanoscale control of reactive fluids  on geological processes within the solid Earth","UNIVERSITEIT UTRECHT","€1,572,500","Fluid-driven mineral reactions chemically modify enormous portions of the Earth’s crystalline lithosphere. These reactions drive fluid-mediated rock transformation processes that governs the stability of mountain belts, the formation of hydrothermal mineral deposits and the sequestration of anthropogenic CO2 as well as many other processes. I propose that contrary to our current thinking, the re-actions themselves are driven by self-promoting nanoscale transport phenomena.Existing geological fra",{"id":367,"funder":7,"programme":8,"title":368,"piName":10,"institution":369,"country":352,"year":13,"amount":370,"abstract":371},"cordis-european-research-council-award-852590","High Throughput Microfluidic Cell and Nanoparticle Handling by Molecular and Thermal Gradient Acoustic Focusing","LUNDS UNIVERSITET","€1,999,720","In this project we will push the limits of microscale ultrasound-based technology to gain access to diagnostically important rare constituents of blood within minutes from blood draw.To meet the demands for shorter time from sampling to result in healthcare there is an increased interest to shift from heavy centralized lab equipment to point-of-care tests and patient self-testing. Key challenges with point-of-care equipment is to enable simultaneous measurement of many parameters at a reasonable",{"id":373,"funder":7,"programme":8,"title":374,"piName":10,"institution":375,"country":97,"year":13,"amount":376,"abstract":377},"cordis-european-research-council-award-802681","How the human thalamus guides navigation and memory: a common coding framework built on direct thalamic recordings","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€1,499,914","The thalamus is the major gateway for sensory input to the brain, and, as such, has long been thought of as a mere sensory relay station. But accumulating evidence suggests that it is crucially involved in higher cognitive functions like memory formation and navigation. However, methodological obstacles still impede full understanding of the specific role of thalamus in human cognition.The core objective of DirectThalamus is to provide an advanced oscillatory model of subcortical processing as t",{"id":379,"funder":7,"programme":8,"title":380,"piName":10,"institution":381,"country":12,"year":13,"amount":382,"abstract":383},"cordis-european-research-council-award-804744","Coupling dynamic population immunity profiles and host behaviours to arboviral spread","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€1,499,896","Arboviruses infect millions of people each year, however, mechanisms that drive viral emergence and maintenance remain largely unknown. A combination of host factors (e.g., human mobility), mosquito factors (e.g., abundance) and viral factors (e.g., transmissibility) interconnect to drive spread. Further, for endemic arboviruses, complex patterns of population immunity, built up over many years, appear key to the emergence of particular lineages. To disentangle the contribution of these differen",{"id":385,"funder":7,"programme":8,"title":386,"piName":10,"institution":387,"country":12,"year":13,"amount":388,"abstract":389},"cordis-european-research-council-award-804383","Many-body theory of antimatter interactions with atoms, molecules and condensed matter","THE QUEEN'S UNIVERSITY OF BELFAST","€1,318,419","The ability of positrons to annihilate with electrons, producing characteristic gamma rays, gives them important use in medicine via positron-emission tomography (PET), diagnostics of industrially-important materials, and in elucidating astrophysical phenomena. Moreover, the fundamental interactions of positrons and positronium (Ps) with atoms, molecules and condensed matter are currently under intensive study in numerous international laboratories, to illuminate collision phenomena and perform ",{"id":391,"funder":7,"programme":8,"title":392,"piName":10,"institution":393,"country":394,"year":13,"amount":395,"abstract":396},"cordis-european-research-council-award-805371","Linguistic Adaptation: Typological and Sociolinguistic Perspectives to Language Variation","HELSINGIN YLIOPISTO","FI","€1,491,493","The GramAdapt project researches linguistic adaptation by developing a synthesis of typological and sociolinguistic approaches to language variation. This novel framework enables combining typological data with rich sociolinguistic data into the same model and evaluating their relationship statistically. The main research question is: Can I prove with typological data that language structure adapts to sociolinguistic context?The project has 4 objectives:- to develop a methodological approach tha",{"id":398,"funder":7,"programme":8,"title":399,"piName":10,"institution":400,"country":246,"year":13,"amount":401,"abstract":402},"cordis-european-research-council-award-804273","Topological states in superconducting two-dimensional electron gases","IBM RESEARCH GMBH","€1,999,916","I will experimentally investigate hybrid superconductor\u002Fsemiconductor devices for realizing novel topological states of matter, with interest both in fundamental physics and quantum computing applications. Common denominator of the proposed experiments is a regime where the characteristic energy scales of the system, namely Fermi energy, spin orbit interaction correction, superconducting gap and Zeeman splitting are comparable to each other, resulting in unique and mostly uncharted physical terr",{"id":404,"funder":7,"programme":8,"title":405,"piName":10,"institution":406,"country":12,"year":13,"amount":19,"abstract":407},"cordis-european-research-council-award-802719","Gestural Origins: Linguistic Features of pan-African Ape Communication","THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS","Understanding the origins of language speaks to the fundamental question of what it means to be human. Other species’ communication contains rich information exchange; but humans do more than broadcast information. Language is used to communicate goals to partners, it goes beyond information: it has meaning. Only great ape gestures show similarly systematic meaningful communication; they are essential to understanding how human language evolved. Beyond meaning, two core features of human languag",{"id":409,"funder":7,"programme":8,"title":410,"piName":10,"institution":411,"country":282,"year":13,"amount":412,"abstract":413},"cordis-european-research-council-award-802830","From light-stimulated anion receptors to transmembrane carriers and pumps","UNIVERSITEIT LEIDEN","€1,499,461","The transport of anions across the cell membrane, which is mediated by transport proteins, is essential to many important biological processes. Dysregulation of this transport has been associated to various diseases and therefore, chemists endeavour  to develop artificial receptors that mimic the function of natural transporters. Despite much progress over the last decade, the current artificial systems are mostly static, while proteins are able to change their activity dynamically in response t",{"id":415,"funder":7,"programme":8,"title":416,"piName":10,"institution":375,"country":97,"year":13,"amount":417,"abstract":418},"cordis-european-research-council-award-803302","Indigeneities in the 21st century: From ‘vanishing people’ to global players in one generation","€1,499,375","10 years after the adoption of the United Nations Declaration on the Rights of Indigenous Peoples in 2007, indigenous stakeholders act as global players in arenas such as the UN Convention on Climate Change, the Dakota Access pipeline in the USA, and the Humboldt-Forum in Berlin. Yet, until the 1960s, anthropological inquiries considered the same people as ‘vanishing’ and doomed to disappear. The so-called Indigenous Renaissance presents a remarkable phenomenon of late (post)modernity. How can t",{"id":420,"funder":7,"programme":8,"title":421,"piName":10,"institution":422,"country":12,"year":13,"amount":423,"abstract":424},"cordis-european-research-council-award-803852","Homologous recombination and its application in manipulating animal mitochondrial DNA","THE UNIVERSITY OF BIRMINGHAM","€1,473,732","Mitochondrial DNA (mtDNA) is a multi-copy genome that works with the nuclear genome to control energy production and various cellular processes. To date, disorders associated with mutations in mtDNA are among the most common genetically inherited metabolic diseases1. However, our knowledge regarding many aspects of mtDNA biology remains limited, and we know even less about how it influences development and organismal traits. This is largely due to our inability to manipulate mtDNA. Recently, a c",{"id":426,"funder":7,"programme":8,"title":427,"piName":10,"institution":428,"country":199,"year":13,"amount":429,"abstract":430},"cordis-european-research-council-award-801954","Wanted: Micronutrients! Phytosiderophore-mediated acquisition strategies in grass crops","UNIVERSITAET FUER BODENKULTUR WIEN","€1,498,628","Understanding how plants respond to micronutrient deficiency and which biogeochemical processes are induced at the root-soil interface, i.e. the rhizosphere, is crucial to improve crop yield and micronutrient grain content for high quality food and feed. Iron nutrition by grass species relies on the release and re-uptake of phytosiderophores, which are root exudates that form stable complexes with Fe but also other trace metals such as Zn and Cu. However, neither the importance of phytosideropho",{"id":432,"funder":7,"programme":8,"title":433,"piName":10,"institution":434,"country":435,"year":13,"amount":436,"abstract":437},"cordis-european-research-council-award-802769","High spatial resolution mapping of catalytic reactions on single nanoparticles","THE HEBREW UNIVERSITY OF JERUSALEM","IL","€1,846,009","Catalytic nanoparticles are heterogeneous in their nature - and even within the simplest particles structural and compositional differences exist and affect the overall performances of a catalyst. Thus non-disruptive, detailed chemical information at the nanoscale is essential for understanding how surface properties direct the reactivity of these particles. Infrared spectroscopy offers a low-energy route towards conducting in-situ, high spatial resolution mapping of catalytic reactions on the s",{"id":439,"funder":7,"programme":8,"title":440,"piName":10,"institution":441,"country":57,"year":13,"amount":442,"abstract":443},"cordis-european-research-council-award-802414","Sea level and extreme waves in the Last Interglacial","UNIVERSITA CA' FOSCARI  VENEZIA","€1,499,965","Past interglacials are periods of the earth’s history when climate was warmer than the pre-industrial, and are often considered as process-analogs for a future warmer climate. During the Last Interglacial (LIG, ~128-116 ka), polar temperatures were few degrees higher than pre-industrial, ice sheets were smaller and sea level was higher than today. Studies also suggest that waves in the North Atlantic might have been more intense in the LIG than today. Understanding sea level changes and extreme ",{"id":445,"funder":7,"programme":8,"title":446,"piName":10,"institution":447,"country":166,"year":13,"amount":448,"abstract":449},"cordis-european-research-council-award-801867","Regularity and singularities in elliptic PDE's: beyond monotonicity formulas","UNIVERSITAT DE BARCELONA","€1,335,250","One of the oldest and most important questions in PDE theory is that of regularity. A classical example is Hilbert's XIXth problem (1900), solved by De Giorgi and Nash in 1956. During the second half of the XXth century, the regularity theory for elliptic and parabolic PDE's experienced a huge development, and many fundamental questions were answered by Caffarelli, Nirenberg, Krylov, Evans, Nadirashvili, Friedman, and many others. Still, there are problems of crucial importance that remain open.",{"id":451,"funder":7,"programme":8,"title":452,"piName":10,"institution":453,"country":97,"year":13,"amount":19,"abstract":454},"cordis-european-research-council-award-802435","Programming Sensory regulation of Metabolism","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","Sensory perception has recently emerged as a master regulator of integrative physiology and behavior, including feeding, by controlling fundamental and pleiotropic regulatory processes of energy and glucose homeostasis. Further, sensory perception is altered in obesity and type 2 diabetes, and childhood obesity correlates with early sensory deficit. Along this line, the discovery of the developmental origins of health and diseases revealed that metabolic diseases have recognized roots in the ver",{"id":456,"funder":7,"programme":8,"title":457,"piName":10,"institution":458,"country":435,"year":13,"amount":459,"abstract":460},"cordis-european-research-council-award-802020","Discrete harmonic analysis for computer science","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","€1,473,750","Boolean function analysis is a topic of research at the heart of theoretical computer science. It studies functions on n input bits (for example, functions computed by Boolean circuits) from a spectral perspective, by treating them as real-valued functions on the group Z_2^n, and using techniques from Fourier and functional analysis. Boolean function analysis has been applied to a wide variety of areas within theoretical computer science, including hardness of approximation, learning theory, cod",{"id":462,"funder":7,"programme":8,"title":463,"piName":10,"institution":453,"country":97,"year":13,"amount":464,"abstract":465},"cordis-european-research-council-award-802923","From Evolution to Clockworks: Unravelling the molecular basis of circalunar clocks","€1,499,728","Circalunar clocks are endogenous biological clocks, which allow organisms to time development and reproduction to lunar phase. They are common in marine organisms, but their molecular basis is still entirely unknown. Candidate gene approaches have failed so far. In the marine midge Clunio marinus (Diptera: Chironomidae), I can elegantly overcome this problem by exploiting an array of local genetic adaptations in circalunar timing. Through evolutionary analysis, QTL mapping and genome screens my ",{"id":467,"funder":7,"programme":8,"title":468,"piName":10,"institution":469,"country":225,"year":13,"amount":470,"abstract":471},"cordis-european-research-council-award-803335","The Lorax Project: Understanding Ecosystemic Politics","NORSK UTENRIKSPOLITISK INSTITUTT","€1,496,848","The Lorax project is a comparative effort to expand our understanding of global political architecture through the consideration of a potential set of ‘missing cases’, namely supranational policy fields organized around regional ecosystems.  The project explores this question: Do regional politics around national border-crossing ecosystems share important resemblances and differ in significant ways from global politics? To address this question, the Lorax project analyzes the networks of actors,",{"id":473,"funder":7,"programme":8,"title":474,"piName":10,"institution":475,"country":352,"year":13,"amount":476,"abstract":477},"cordis-european-research-council-award-851753","Species discrimination in birds: A behavioural-neurogenomics approach to auditory learning","STOCKHOLMS UNIVERSITET","€1,490,850","How individuals choose mates is a fundamental question in evolutionary biology. Mating decisions have broad consequences, influencing individual fitness and population-level evolutionary and ecological processes, including diversification, speciation, and extinction. Discriminating against potential mates from closely related co-occurring species is a vital step in finding an appropriate mate. However, individuals from many species learn with whom to mate by first observing a variety of conspeci",{"id":479,"funder":7,"programme":8,"title":480,"piName":10,"institution":481,"country":482,"year":13,"amount":483,"abstract":484},"cordis-european-research-council-award-804881","Epigenetics, Experience and Responsibility: Implications for neurodevelopmental disorders","UNIVERSITEIT ANTWERPEN","BE","€1,453,012","In folk psychology and in bioethical discussions, the central dogma of genetics is often taken for granted: humans are seen as defined in a genetic blueprint. The conceptualization of psychiatric conditions as innate or acquired, biological or psychosocial, genetic or environmental, influences the ascription of both capacity responsibility (the capacity to adapt or adjust one’s own behavior) and normative responsibility of individuals or the society towards those diagnosed. But findings in the f",{"id":486,"funder":7,"programme":8,"title":487,"piName":10,"institution":488,"country":282,"year":13,"amount":489,"abstract":490},"cordis-european-research-council-award-850590","Competition, time pressure, public speaking and multitasking: The role of willingness and ability to cope with pressure in explaining individual differences and inequality in career outcomes","UNIVERSITEIT VAN AMSTERDAM","€1,335,536","Inequalities in study choices and career outcomes between population groups, including Inequalities in study choices and career outcomes between population groups, including differences across gender and socioeconomic background, are highly persistent. This hints at unobserved barriers that limit diversity and prevent people from selecting the careers they would be most productive in. As a society, this may keep us from having the best people in the most important positions. Our limited understa",{"id":492,"funder":7,"programme":8,"title":493,"piName":10,"institution":494,"country":12,"year":13,"amount":495,"abstract":496},"cordis-european-research-council-award-852915","Coat assembly and membrane remodelling: understanding regulation of protein secretion","BIRKBECK COLLEGE - UNIVERSITY OF LONDON","€1,499,175","Eukaryotic cells are organised in membrane-bound compartments, which have defined chemical identities and carry out specific essential functions. Exchange of material between these compartments is necessary to maintain cell functionality, and is achieved in a highly specific and regulated manner by vesicular transport. To mediate protein trafficking, coat complexes assemble on membranes and couple bilayer deformation with cargo capture into transport carriers. How coat assembly can deliver the f",{"id":498,"funder":7,"programme":8,"title":499,"piName":10,"institution":351,"country":352,"year":13,"amount":500,"abstract":501},"cordis-european-research-council-award-804662","Varieties of Media Effects","€1,495,595","The overall objective of VARME is to determine the long-term effects of the news media on citizens’ beliefs about societal problems. Theoretically and empirically, the program challenges the prevailing Short-term Media Effects Paradigm that characterizes most research on media effects. In doing so, the program uncovers a variety of important long-term media effects largely ignored in previous research. These include how beliefs about societal problems are initially formed (RQ1), how beliefs are ",{"id":503,"funder":7,"programme":8,"title":504,"piName":10,"institution":505,"country":97,"year":13,"amount":506,"abstract":507},"cordis-european-research-council-award-802205","Computational Modelling, Topological Optimization and Design of Flexoelectric Nano Energy Harvesters","GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER","€1,499,938","Flexoelectricity is the generation of electric polarization under mechanical strain gradient or mechanical deformation due to the electric field gradient (converse flexo). It is a more general phenomenon than the linear change in polarization due to stress, the piezoelectric effect. Flexoelectricity exists in a wider range of centrosymmetric materials especially nontoxic materials useful for biomedical application. It grows dominantly in energy density at submicro- or nanoscale enabling self-pow",{"id":509,"funder":7,"programme":8,"title":510,"piName":10,"institution":511,"country":12,"year":13,"amount":19,"abstract":512},"cordis-european-research-council-award-852558","Ancient genomic reconstruction of convergent evolution to agriculture","THE FRANCIS CRICK INSTITUTE LIMITED","As global climates warmed ca. 10,000 years ago came a remarkable convergent transformation of human lifestyles that occurred independently in multiple continents and human populations. This transition from hunter-gatherer subsistence to food-production catalysed large-scale population growth, offering the opportunity for increased rates of adaptation, but also rapidly presented a large number of independent human populations with a new evolutionary challenge. This project will use ancient popula",{"id":514,"funder":7,"programme":8,"title":515,"piName":10,"institution":375,"country":97,"year":13,"amount":516,"abstract":517},"cordis-european-research-council-award-852332","The Consequences of Mismeasuring Economic Activity","€1,337,016","Measuring economic activity is a fundamental challenge for empirical work in economics. Most empirical projects raise concerns about whether the data do in fact measure what they purport to measure. Mismeasurement may lead to severe model misspecification, biased estimates, and misled conclusions and policy decisions. Unfortunately, formally accounting for the possibility of mismeasurement in the econometric model is complicated and possible only under strong assumptions that limit the credibili",{"id":519,"funder":7,"programme":8,"title":520,"piName":10,"institution":363,"country":282,"year":13,"amount":521,"abstract":522},"cordis-european-research-council-award-802636","3D Flow Analysis in Bijels Reconfigured for Interfacial Catalysis","€1,905,000","The objective of this proposal is to determine the unknown criteria for convective cross-flow in bicontinuous interfacially jammed emulsion gels (bijels). Based on this, we will answer the question: Can continuously operated interfacial catalysis be realized in bijel cross-flow reactors? Demonstrating this potential will introduce a broadly applicable chemical technology, replacing wasteful chemical processes that require organic solvents. We will achieve our objective in three steps: (a) Contro",{"id":524,"funder":7,"programme":8,"title":525,"piName":10,"institution":526,"country":97,"year":13,"amount":417,"abstract":527},"cordis-european-research-council-award-850979","Technology Transfer between Integer Programming and Efficient Algorithms","UNIVERSITAT DES SAARLANDES","This project aims to resolve challenging integer programming problems in exact and approximate settings, with a focus on Knapsack-type problems (such as Subset Sum, Partition, and Knapsack). To this end, we will develop a unified approach of algorithm design as a combination of algorithmic tools, structural theory, and conditional lower bounds. Specific tasks include:- utilizing recent advances in efficient algorithms, since although Knapsack-type algorithms are NP-hard their main challenges ask",{"id":529,"funder":7,"programme":8,"title":530,"piName":10,"institution":531,"country":532,"year":13,"amount":533,"abstract":534},"cordis-european-research-council-award-803908","Seismic Testing of 3D Printed Miniature Masonry in a Geotechnical Centrifuge","ETHNICON METSOVION POLYTECHNION","EL","€1,999,477","Earthquakes are responsible for more than half of the human losses due to natural disasters. Masonry structures have been proven the most vulnerable both in the developing and in the developed world. Even though Masonry is one of the oldest building materials, our understanding of its behavior at the level of the structure (system level) is limited. Therefore, there is a need for extended shake table testing. But shake table tests are expensive and full-scale system-level testing of large buildi",{"id":536,"funder":7,"programme":8,"title":537,"piName":10,"institution":538,"country":12,"year":13,"amount":539,"abstract":540},"cordis-european-research-council-award-802424","Climate, Landscape, Settlement and Society: Exploring Human-Environment Interaction in the Ancient Near East","UNIVERSITY OF DURHAM","€1,498,650","Over the last 8000 years, the Fertile Crescent of the Near East has seen the emergence of cities, states and empires. Climate fluctuations are generally considered to be a significant factor in these changes because in pre-industrial societies they directly relate to food production and security. In the short term, ‘collapse’ events brought about by extreme weather changes such as droughts have been blamed for declines in population, social complexity and political systems. More broadly, the rel",{"id":542,"funder":7,"programme":8,"title":543,"piName":10,"institution":544,"country":97,"year":13,"amount":545,"abstract":546},"cordis-european-research-council-award-804416","Entanglement in Strongly Correlated Quantum Many-Body Systems with Ultracold Atoms","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","€1,787,564","Entanglement plays a central role for strongly correlated quantum many-body systems and is considered to be the root for a number of surprising emergent phenomena in solids such as high-temperature superconductivity or fractional Quantum Hall states. Entanglement detection in these systems is an important target of current research, but has so far remained elusive owing to the fine control required and high demands on statistical sampling.The goal of this project is to realize strongly correlate",{"id":548,"funder":7,"programme":8,"title":549,"piName":10,"institution":475,"country":352,"year":13,"amount":19,"abstract":550},"cordis-european-research-council-award-803189","Three-dimensional spectral modelling of astrophysical transients : unravelling the nucleosynthetic content of supernovae and kilonovae","Determining the origin of the elements is a fundamental quest in physics and astronomy. Most of the elements in the periodic table are believed to be produced by supernovae and kilonovae. However, this has for decades been little more than a prediction from theory. Now, with a dramatically changing observational situation and new modelling capabilities, it is within our reach to determine the nucleosynthesis production and structure in these transients. To really see what supernovae and kilonova",{"id":552,"funder":7,"programme":8,"title":553,"piName":10,"institution":139,"country":75,"year":13,"amount":554,"abstract":555},"cordis-european-research-council-award-801728","Investigating micro-RNA Dynamics using Paramagnetic NMR Spectroscopy","€1,633,500","Over the last decades, new discoveries have revealed an ever-increasing diversity of RNA functions, profoundly modifying the conceptual framework of molecular biology. This is the case of micro-RNAs (miRNA), a fascinating class of small non-coding RNA that play essential roles in RNA induced gene silencing and are estimated to target up to 60% of protein-coding genes in humans.RNA functional diversity is often triggered by conformational changes, so capturing the dynamics of these molecules is k",{"id":557,"funder":7,"programme":8,"title":558,"piName":10,"institution":559,"country":12,"year":13,"amount":10,"abstract":560},"cordis-european-research-council-award-804971","REFUGEES, POVERTY AND ECONOMIC GROWTH","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","Globally, nearly one in every 100 humans is now either a refugee or internally displaced. Over 95% of the refugee population is concentrated in the developing world, 60% of which are in fragile states. The 36 most fragile countries in the world account for 2.6% of global GDP but host 71% of the world’s population of forcibly displaced people. This stands in contrast to the 4% of world refugees currently hosted by the US or the 5% of refugees seeking asylum in Europe. The number of refugees in th",{"id":562,"funder":7,"programme":8,"title":563,"piName":10,"institution":564,"country":75,"year":13,"amount":565,"abstract":566},"cordis-european-research-council-award-805225","Vessel co-option and radioresistance in glioblastoma","INSTITUT CURIE","€1,499,823","Glioblastoma (GBM) is one of the deadliest types of human cancer. Despite a very aggressive treatment regime – including resection of the tumor, radiation and chemotherapy – its estimated recurrence rate is more than 90%. Recurrence is mostly caused by the regrowth of highly invasive cells spreading from the tumor bulk, which are not removed by resection. To develop an effective therapeutic approach, we need to better understand the underlying molecular mechanism of radiation resistance and tumo",{"id":568,"funder":7,"programme":8,"title":569,"piName":10,"institution":139,"country":75,"year":13,"amount":570,"abstract":571},"cordis-european-research-council-award-851146","Cohomology and Singularities","€1,466,124","The singularities of algebraic varieties and, more generally, Noetherian schemes, tend to be reflected in the structural properties of cohomology. The goal of the project is to study this interplay, with a particular focus on positive and mixed characteristic---arithmetic settings in which the recently developed perfectoid techniques are especially relevant. The project highlights several interrelated conjectures, for instance, purity for flat cohomology, that would further our understanding of ",{"id":573,"funder":7,"programme":8,"title":574,"piName":10,"institution":575,"country":12,"year":13,"amount":576,"abstract":577},"cordis-european-research-council-award-852577","Information Frictions, Financing and Growth:  The Impact of Firm Certification","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€1,357,099","This project will provide new knowledge on the mechanisms through which finance, and the relaxation of informational frictions for firms can promote economic growth. A big challenge in the field of corporate finance is to establish causality, and cleanly identify the impact of frictions on corporate outcomes. I aim to transform the frontier of knowledge in my field by using state of the art methodology in finance and economics that allows inferring causality.  I will exploit a public policy prog",{"id":579,"funder":7,"programme":8,"title":580,"piName":10,"institution":575,"country":12,"year":13,"amount":581,"abstract":582},"cordis-european-research-council-award-804176","P-adic Arithmetic Geometry, Torsion Classes, and Modularity","€1,469,805","The overall theme of the proposal is the interplay between p-adic arithmetic geometry and the Langlands correspondence for number fields. At the heart of the Langlands program lies reciprocity, which connects Galois representations to automorphic forms. Recently, new developments in p-adic arithmetic geometry, such as the theory of perfectoid spaces, have had a transformative effect on the field. This proposal would establish a research group that will develop and exploit novel techniques, that ",{"id":584,"funder":7,"programme":8,"title":585,"piName":10,"institution":139,"country":75,"year":13,"amount":586,"abstract":587},"cordis-european-research-council-award-803151","The macroevolutionary impact of epigenetics and lateral gene transfer on eukaryotic genomes","€1,499,945","Multicellular organisms (e.g., animals, fungi and plants) are the best-studied eukaryotes but their ancestors and the vast majority of eukaryotic diversity correspond to microbial species (“protists”). The evolutionary history of protists is closely connected to the evolution of the eukaryotic cell itself.However, most protist diversity is still genomically unexplored, limiting our investigation of eukaryotic evolution. For example, while the importance of lateral gene transfer (LGT) in prokaryo",{"id":589,"funder":7,"programme":8,"title":590,"piName":10,"institution":139,"country":75,"year":13,"amount":591,"abstract":592},"cordis-european-research-council-award-803004","New sensor devices based on soft chemistry assisted nanostructured functional oxides on Si integrated systems","€1,499,360","Piezoelectrics are the active elements of many everyday applications, from ink-jet printers to ultrasound generators, representing a billion euro industry. They are the key elements of motion sensors and resonators present in any wireless network sensor (WNS) node. However, an increased production of piezoelectrics in a sustainable way is to-date a milestone. SENSiSOFT proposes to come up with materials that can provide a solution to this problem: piezoelectric materials that are abundant, cheap",{"id":594,"funder":7,"programme":8,"title":595,"piName":10,"institution":139,"country":75,"year":13,"amount":596,"abstract":597},"cordis-european-research-council-award-805256","Exploring the nucleation of large earthquakes: cascading and unpredictable or slowly driven and forecastable","€1,499,545","How do earthquakes begin? Answering this question is essential to understand fault mechanics but also todetermine our ability to forecast large earthquakes. Although it is well established that some events are preceded by foreshocks, contrasting views have been proposed on the nucleation of earthquakes. Do these foreshocks belong to a cascade of random failures leading to the mainshock? Are they triggered by an aseismic nucleation phase in which the fault slips slowly before accelerating to a dy",{"id":599,"funder":7,"programme":8,"title":600,"piName":10,"institution":139,"country":75,"year":13,"amount":10,"abstract":601},"cordis-european-research-council-award-802699","Thermal Evolution Modeling of Icy objects in the Solar System","Comets can be used as tracers of the conditions prevailing during the formation of the solar system. We have been studying them for decades, yet we still have not answered this foreground question: how do comets work? To answer that question is to understand which of comets properties are actually relevant to characterize the early solar system, and how primitive comets really are. Icy objects in the solar system are stored in different reservoirs, where they evolve very slowly owing irradiation",{"id":603,"funder":7,"programme":8,"title":604,"piName":10,"institution":139,"country":75,"year":13,"amount":605,"abstract":606},"cordis-european-research-council-award-805252","Local Control of Macroscopic Properties in Isolated Many-body Quantum Systems","€1,499,716","Studies of many-body quantum systems in the last century have been mainly focussed on equilibrium properties; the systems of interest were typically coupled to an environment, which brings about relaxation after short times. The situation changed with the advent of experiments on clouds of ultra-cold, trapped atoms. These are by design almost isolated, and allow for investigations into nonequilibrium dynamics before the onset of dissipative processes. The characterization of such dynamics is now",{"id":608,"funder":7,"programme":8,"title":609,"piName":10,"institution":139,"country":75,"year":13,"amount":610,"abstract":611},"cordis-european-research-council-award-801774","Real-time diffusion NMR analysis of mixtures","€1,499,307","Chemical samples often come as solution mixtures. While advanced analytical methods exist for samples at equilibrium, the information on components and their interactions that may be accessed for the frequent and important case of out-of-equilibrium mixtures is much more limited. The DINAMIX project will tackle this challenge and provide detailed, molecular-level information on out-of-equilibrium mixtures. The proposed concept relies on diffusion nuclear magnetic resonance (NMR) spectroscopy, a ",{"id":613,"funder":7,"programme":8,"title":614,"piName":10,"institution":139,"country":75,"year":13,"amount":615,"abstract":616},"cordis-european-research-council-award-805080","PROBING EXOTIC QUANTUM HALL STATES WITH HEAT QUANTUM TRANSPORT","€1,499,839","Under high magnetic field and at low temperatures, electronic interactions in a two-dimensional electron gas give rise to exotic, strongly correlated many-body quantum Hall states. These states have been proposed for the implementation of new quantum circuits, for instance realizing topologically protected quantum computing. Although exciting, these states remain poorly understood, because the conventional experimental approach for their investigation, dc electron transport, only yields limited ",{"id":618,"funder":7,"programme":8,"title":619,"piName":10,"institution":620,"country":199,"year":13,"amount":621,"abstract":622},"cordis-european-research-council-award-803768","Evolution of Physiology: The link between Earth and Life","UNIVERSITAT WIEN","€1,499,998","The history of life is a subject that attracts the interest from both researchers and the society in general - it is in the human nature to wonder about our own history. Our only sources of information about microbial evolution reside in genomic data and geological records. Major advances in sequencing techniques are overwhelming databases with rich and novel insights into microbial taxonomic diversity, in particular about new uncultured lineages. Through metagenomics we now know that they are t",{"id":624,"funder":7,"programme":8,"title":625,"piName":10,"institution":626,"country":97,"year":13,"amount":417,"abstract":627},"cordis-european-research-council-award-805338","Targeting genetic and epigenetic mechanisms in pediatric sarcomas.","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","Sarcomas are an extremely heterogeneous group of mesenchymal tumors that arise in a multitude of tissues from many different cell types. Several genetic events have been identified in different sarcoma sub-types, but very few models were developed to study their role in tumorigenesis aiming at exploiting them as therapeutic vulnerabilities. As a result, the treatment of sarcoma has extremely limited advancement in therapeutic options compared to other cancers. Therefore, the generation of faithf",{"id":629,"funder":7,"programme":8,"title":630,"piName":10,"institution":631,"country":282,"year":13,"amount":632,"abstract":633},"cordis-european-research-council-award-805308","Targeted microbubble vibrations to accurately diagnose and treat cardiac device-related bacterial biofilm infections","ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM","€1,878,000","Due to an aging population, increasingly more cardiac devices are implanted (pacemaker\u002FICD\u002FCRT\u002F prosthetic valve\u002FLVAD; worldwide ~2 million yearly). Life-threatening bacterial infections (1-60% infection and 29-50% mortality rate) associated with these devices are a major healthcare burden and pose scientific challenges. Ultrasound imaging is currently the primary diagnostic modality. However, it lacks specificity and sensitivity because the signal from the bacteria is similar to the signal of h",{"id":635,"funder":7,"programme":8,"title":636,"piName":10,"institution":637,"country":225,"year":13,"amount":638,"abstract":639},"cordis-european-research-council-award-804150","Co-production of seasonal representations for adaptive institutions","UNIVERSITETET I BERGEN","€1,489,426","Climate change may be undermining the stock of seasonal representations that society draws on to understand and live according to the weather. The CALENDARS project studies how modern society represents seasons, and how these representations shape institutions and help people live with seasonal change. The project opens an important emerging field in climate adaptation research by examining the representations of ‘normal’ seasons underlying key institutions, assesses their quality for successful",{"id":641,"funder":7,"programme":8,"title":642,"piName":10,"institution":643,"country":282,"year":13,"amount":644,"abstract":645},"cordis-european-research-council-award-802202","Meaningful Mobility: a novel approach to movement within and between places in later life","RIJKSUNIVERSITEIT GRONINGEN","€1,499,225","Mobility or physical movement contributes to health and well-being in later life and is a key issue in gerontological research. Most studies have focused on the contribution of outdoor mobility to active ageing, but physical and cognitive impairments restrict the mobility of many older adults. MeaningfulMobility will take a more comprehensive approach than previous research. It will be the first to connect the capability approach to mobility research to study diversity in movement within and bet",{"id":647,"funder":7,"programme":8,"title":648,"piName":10,"institution":649,"country":650,"year":13,"amount":651,"abstract":652},"cordis-european-research-council-award-803239","Cognitive Aging: From Educational Opportunities to Individual Risk Profiles","UNIVERSITE DU LUXEMBOURG","LU","€1,148,290","Cognitive impairment and dementia have dramatic individual and social consequences, and create high economic costs for societies. In order to delay cognitive aging of future generations as long as possible, we need evidence about which contextual factors are most supportive for individuals to reach highest cognitive levels relative to their potential. At the same time, for current older generations, we need scalable methods to exactly identify individuals at risk of cognitive impairment. The pro",{"id":654,"funder":7,"programme":8,"title":655,"piName":10,"institution":656,"country":657,"year":13,"amount":658,"abstract":659},"cordis-european-research-council-award-805038","Searching for novel strategies improving cancer immunotherapy","INSTYTUT MEDYCYNY DOSWIADCZALNEJ I KLINICZNEJ IM MIROSLAWA MOSSAKOWSKIEGO POLSKIEJ AKADEMII NAUK","PL","€1,498,750","The main goal of this project is to explore new fundamental pathways involved in the regulation of antitumor immune response. Since the immunosuppressive tumor microenvironment constitutes a key barrier to effective immunotherapy, our predominant ambition is to characterize novel, hitherto unknown metabolic changes that can support the survival of tumor cells and the escape from the immune surveillance. We have recently discovered a new metabolite within tumor microenvironment with a robust abil",{"id":661,"funder":7,"programme":8,"title":662,"piName":10,"institution":663,"country":435,"year":13,"amount":664,"abstract":665},"cordis-european-research-council-award-850041","Anharmonic Semiconductors","WEIZMANN INSTITUTE OF SCIENCE","€1,700,000","Recent studies of halide perovskite semiconductors (SCs) showed that they exhibit a unique combination of very-low defect density, self-healing properties and low exciton binding energies that result in excellent photovoltaic activity.I hypothezise that the fundamental property that sets the halide perovskites apart from conventional SCs and gives rise to their beneficial properties is strongly anharmonic lattice dynamics.Large amplitude, local polar fluctuations that result from lattice anharmo",{"id":667,"funder":7,"programme":8,"title":668,"piName":10,"institution":334,"country":246,"year":13,"amount":669,"abstract":670},"cordis-european-research-council-award-803491","Elucidating the molecular mechanisms underlying brite adipocyte specification and activation","€1,552,620","Brown adipocytes can dissipate energy in a process called adaptive thermogenesis. Whilst the classical brown adipose tissue (BAT) depots disappear during early life in humans, cold exposure can promote the appearance of brown-like adipocytes within the white adipose tissue (WAT), termed brite (brown-in-white). Increased BAT activity results in increased energy expenditure and has been correlated with leanness in humans. Hence, recruitment of brite adipocytes may constitute a promising therapeuti",{"id":672,"funder":7,"programme":8,"title":673,"piName":10,"institution":674,"country":435,"year":13,"amount":10,"abstract":675},"cordis-european-research-council-award-802752","Modelling Anthropocene Trophic Cascades of the Judean Desert Ecosystem: A Hidden Dimension in the History of Human-Environment Interactions","UNIVERSITY OF HAIFA","This project aims to explore the effects of human settlement intensity on desert ecological community structure, focusing on the hitherto unstudied phenomenon of trophic cascades in antiquity. Its key research question is whether human-induced changes in arid land biodiversity can feedback to affect natural resources important for human subsistence, such as pasture and wood. The role of such feedback effects in ecological systems is increasingly acknowledged in recent years in the biological lit",{"id":677,"funder":7,"programme":8,"title":678,"piName":10,"institution":679,"country":352,"year":13,"amount":680,"abstract":681},"cordis-european-research-council-award-804988","Simulated Majorana states","CHALMERS TEKNISKA HOGSKOLA AB","€1,997,513","Quantum computation using topologically protected Majorana bound states is a promising direction towards scalable quantum architectures due to their inherent noise immunity provided by the nonlocal storage of quantum information. Thus far, Majorana states have mostly been investigated in superconductor-semiconductor heterostructures which rely on induced superconductivity in a quasi-one-dimensional conductor. However, despite tremendous efforts in material development, these devices are still li",{"id":683,"funder":7,"programme":8,"title":684,"piName":10,"institution":453,"country":97,"year":13,"amount":685,"abstract":686},"cordis-european-research-council-award-803111","A Theory-Oriented Real-Time Operating System for Temporally Sound Cyber-Physical Systems","€1,499,813","The TOROS project targets the challenge of implementing safety-critical cyber-physical systems (CPSs) on commodity  multicore processors such that their temporal correctness can be certified in a formal, trustworthy manner.While today  it is in principle possible to construct a CPS in a temporally sound way, in practice   this rarely happens because, with the current real-time foundations, the prerequisite investments in time, expertise, and resources are prohibitive. This situation is caused in",{"id":688,"funder":7,"programme":8,"title":689,"piName":10,"institution":690,"country":97,"year":13,"amount":691,"abstract":692},"cordis-european-research-council-award-802822","Coupled Organic Inorganic Nanostructures for Fast, Light-Induced Data Processing","EBERHARD KARLS UNIVERSITAET TUEBINGEN","€1,497,375","The main objective of this project is to design optical switches with a response time \u003C 5 ps, a switching energy \u003C 1 fJ\u002Fbit and compatibility with silicon technology to excel in high-speed data processing at low heat dissipation. This will be pursued by combining the chemistry of inorganic, nanocrystalline colloids and organic semiconductor molecules to fabricate thin films of organic-inorganic hybrid nanostructures. Optical switches play a pivotal role in modern data processing based on silicon",{"id":694,"funder":7,"programme":8,"title":695,"piName":10,"institution":369,"country":352,"year":13,"amount":696,"abstract":697},"cordis-european-research-council-award-801847","High resolution X-ray detectors based on nanowire arrays","€1,498,971","In this project I will develop ultra-high resolution X-ray detectors based on semiconductor nanowires, whose spatial resolution will be radically better than the current state of the art. In X-ray detectors the primary X-ray absorption induces a cascade of secondary electrons and photons which are measured at the front or back of the detector, but during the long transport to the point of detection these can spread orthogonally to the optical axis. This limits the resolution in present bulk dete",{"id":699,"funder":7,"programme":8,"title":700,"piName":10,"institution":701,"country":57,"year":13,"amount":702,"abstract":703},"cordis-european-research-council-award-803621","Light INduced Cell control by Exogenous organic semiconductors","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","€1,866,250","LINCE will develop light-sensitive devices based on organic semiconductors (OS) for optical regulation of living cells functions.The possibility to control the activity of biological systems is a timeless mission for neuroscientists, since it allows both to understand specific functions and to manage dysfunctions. Optical modulation provides, respect to traditional electrical methods, unprecedented spatio-temporal resolution, lower invasiveness, and higher selectivity. However, the vast majority",{"id":705,"funder":7,"programme":8,"title":706,"piName":10,"institution":707,"country":57,"year":13,"amount":708,"abstract":709},"cordis-european-research-council-award-802862","HYbrid NANOstructured multi-functional interfaces for stable, efficient and eco-friendly photovoltaic devices","UNIVERSITA DEGLI STUDI DI PAVIA","€1,499,084","HY-NANO focuses on one of the current major challenges in Europe: a global transition to a low-carbon society and green economy by 2050. Solar energy can lead a “paradigm shift” in the energy sector with a new low-cost, efficient, and stable technology (3-pillars strategy). Nowadays, low-cost three dimensional (3D) Hybrid Perovskites (HP) solar cells are revolutionizing the photovoltaic scene, with stunning power conversion efficiency beyond 22%. However, poor device stability (due to degradatio",{"id":711,"funder":7,"programme":8,"title":712,"piName":10,"institution":334,"country":246,"year":13,"amount":713,"abstract":714},"cordis-european-research-council-award-853064","Hybrid Electrocatalysts Inspired by the Nitrogenase Enzyme","€1,498,445","Artificial nitrogen reduction to ammonia using the Haber-Bosch process directly supports half of the global food production and accounts for 2% of the global energy consumption. This large consumption of energy originates mostly from the use of H2 (derived from fossil fuels) as a reductant and from the high pressure and temperature required to undertake the Haber-Bosch process. Electrochemical synthesis of ammonia, using a proton and electron source combined with an electrocatalyst at room tempe",{"id":716,"funder":7,"programme":8,"title":717,"piName":10,"institution":718,"country":282,"year":13,"amount":19,"abstract":719},"cordis-european-research-council-award-850571","Deciphering the cellular origin and evolution of malignant rhabdoid tumors","PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV","Introduction How tumors adapt to changing environmental conditions and treatment is a major unsolved problem frustrating effective therapy. Rhabdoid tumors are highly aggressive pediatric tumors with a low survival rate. They occur in multiple tissues, including brain and kidney, and likely originate as a consequence of aberrant differentiation during development. Understanding the origin of rhabdoid tumors and the relationship with normal development is crucial for investigating new treatment o",{"id":721,"funder":7,"programme":8,"title":722,"piName":10,"institution":723,"country":97,"year":13,"amount":724,"abstract":725},"cordis-european-research-council-award-805230","Protein synthesis in organelles","UNIVERSITAET MUENSTER","€1,331,300","Protein synthesis in mitochondria is essential for the bioenergetics, whereas its counterpart in chloroplasts is responsible for the synthesis of the core proteins that ultimately converts sunlight into the chemical energy that produces oxygen and organic matter. Recent insights into the mito- and chlororibosomes have provided the first glimpses into the distinct and specialized machineries that involved in synthesizing almost exclusively hydrophobic membrane proteins. Our findings showed: 1) mi",{"id":727,"funder":7,"programme":8,"title":728,"piName":10,"institution":729,"country":482,"year":13,"amount":150,"abstract":730},"cordis-european-research-council-award-805222","Integrated high-resolution on-chip structured illumination microscopy","INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM","Fluorescent microscopy is an indispensable tool in biology and medicine that has fueled many breakthroughs in a wide set of sub-domains.Recently the world of microscopy has witnessed a true revolution in terms of increased resolution of fluorescent imaging techniques. To break the intrinsic diffraction limit of the conventional microscope, several advanced super-resolution techniques were developed, some of which have even been awarded with the Nobel Prize in 2014. High resolution microscopy is ",{"id":732,"funder":7,"programme":8,"title":733,"piName":10,"institution":663,"country":435,"year":13,"amount":19,"abstract":734},"cordis-european-research-council-award-851080","Elucidating the Molecular Mechanism of  Myoblast Fusion in Vertebrates","Cell-to-cell fusion is a ubiquitous phenomenon essential for the physiological function of numerous tissues. A striking example is the fusion of myoblasts to form multinucleated myofibers during skeletal muscle development and regeneration. During myoblast fusion, membrane architecture must be radically remodeled. Yet, how membrane remodeling occurs on the molecular level is poorly understood as, until now, there was no approach available for visualizing dynamic changes in the cellular ultrastru",{"id":736,"funder":7,"programme":8,"title":737,"piName":10,"institution":453,"country":97,"year":13,"amount":738,"abstract":739},"cordis-european-research-council-award-803984","Molecular diversification of inhibitory neurons during development","€1,493,382","Cortical interneurons are a diverse class of inhibitory neurons that play a particularly important role in the stability of the neural circuits underlying cognitive and higher order brain functions. A growing body of evidence suggests that perturbation of interneuron development can result in a variety of complex neuropsychiatric disorders, including autism, bipolar disorder, and schizophrenia. Thus, elucidating how interneurons develop and integrate into canonical brain circuits is crucial for ",{"id":741,"funder":7,"programme":8,"title":742,"piName":10,"institution":743,"country":12,"year":13,"amount":744,"abstract":745},"cordis-european-research-council-award-804701","Challenging and extending predictive coding as an account of brain function","UNIVERSITY OF EAST ANGLIA","€1,464,713","Probabilistic models of brain function, which propose that the brain can be understood as implementing the principles of optimal statistical inference, have become extremely influential in recent years. Predictive coding is perhaps the most widely held, and best supported, of these models, particularly within cognitive neuroscience. However, current models of predictive coding and its neuronal substrates are still relatively simple, and do not explain how humans solve a number of fundamental pro",{"id":747,"funder":7,"programme":8,"title":748,"piName":10,"institution":422,"country":12,"year":13,"amount":749,"abstract":750},"cordis-european-research-council-award-804752","Mapping Stellar Helium","€1,496,203","In the epoch of Gaia, fundamental stellar properties will be made widely available for large numbers of stars.  These properties are expected to unleash a new wave of discovery in the field of astrophysics.  But while many properties of stars are measurable, meaningful Helium abundances (Y) remain elusive and as a result fundamental properties are not accurate.Helium enrichment laws, which underpin most stellar properties, link initial Y to initial metallicity, but these relations are very uncer",{"id":752,"funder":7,"programme":8,"title":753,"piName":10,"institution":707,"country":57,"year":13,"amount":754,"abstract":755},"cordis-european-research-council-award-804583","Sustainable Approach to Drug Discovery","€1,400,000","Modern drug discovery is facing critical challenges. Rapid advances in human biology are revealing new biomolecular targets and processes, for which existing chemical compound libraries can provide only limited success in the identification of novel bioactive agents. This deficiency has been attributed primarily to the relative lack of structural diversity within the libraries. The three-dimensional world of biological macromolecules has been continuously interrogated with generally similar plan",{"id":757,"funder":7,"programme":8,"title":758,"piName":10,"institution":198,"country":199,"year":13,"amount":759,"abstract":760},"cordis-european-research-council-award-801770","Angulon: physics and applications of a new quasiparticle","€1,499,588","This project aims to develop a universal approach to angular momentum in quantum many-body systems based on the angulon quasiparticle recently discovered by the PI. We will establish a general theory of angulons in and out of equilibrium, and apply it to a variety of experimentally studied problems, ranging from chemical dynamics in solvents to solid-state systems (e.g. angular momentum transfer in the Einstein-de Haas effect and ultrafast magnetism).The concept of angular momentum is ubiquitous",{"id":762,"funder":7,"programme":8,"title":763,"piName":10,"institution":334,"country":246,"year":13,"amount":19,"abstract":764},"cordis-european-research-council-award-851809","From Network Verification to Synthesis: Breaking New Ground in Network Automation","Nearly half of Japan without Internet for hours; thousands of airline passengers grounded; 600+ emergency calls not received. These are just three recent illustrations of the consequences of human-induced network misconfigurations. Such errors are caused by a fundamental gap: distilling the high-level requirements network operators have in mind into complex, low-level device configurations. In 2018, network operators are still trying to bridge this gap manually.The goal of this proposal is to ad",{"id":766,"funder":7,"programme":8,"title":767,"piName":10,"institution":768,"country":97,"year":13,"amount":769,"abstract":770},"cordis-european-research-council-award-802482","Specificity or generalization? Neural mechanisms for perceptual learning with variability","UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS","€1,867,332","The visual system is equipped with a powerful plasticity mechanism, perceptual learning, which serves to improve perception of consistent inputs. However, the signals it receives are extremely variable. How variability affects perceptual learning is unclear. Here, I ask how the visual system tackles the challenge of variability for learning: variability could impair perceptual learning, or, like in language and motor learning, result in the ability to generalize from trained to new materials. To",{"id":772,"funder":7,"programme":8,"title":773,"piName":10,"institution":774,"country":435,"year":13,"amount":775,"abstract":776},"cordis-european-research-council-award-852925","Straining electromechanical coupling in layered crystals to new extremes","TEL AVIV UNIVERSITY","€1,766,875","Inherent stability of layered 2D materials supports a remarkably large strain along the plane of these 1-atom-thick crystals. For example, graphene and MoS2 can stretch, in principle, by 20% - ten times more than the typical intrinsic breakdown strain of 3D crystals. Such extreme deformations of the interatomic distance can drive exciting structural phase transitions, support fascinating electronic orders, and pro-foundly impact the electronic or optical response. Individually, however, pulling ",{"id":778,"funder":7,"programme":8,"title":779,"piName":10,"institution":10,"country":10,"year":13,"amount":19,"abstract":780},"cordis-european-research-council-award-804259","Writers handling pictures: a material intermediality (1880-today)","Not only does the writer’s hand hold the pen, it manipulates pictures as well. Writers touch, hoard, cut, copy, pin and paste various kinds of pictures and these actions integrate literature in visual culture in many ways that have never been tackled as a whole before.Some writers spent their life surrounded by pictures taken from magazines, creating an inspirational environment; yet others nurtured their imagination with touristic leaflets and visual advertisements; others created fictional cha",{"id":782,"funder":7,"programme":8,"title":783,"piName":10,"institution":10,"country":10,"year":13,"amount":784,"abstract":785},"cordis-european-research-council-award-803614","Welfare for Migrant Factory Workers: Moral Struggles and Politics of Care under Market Socialism","€1,499,325","The transformation of China and Vietnam from centrally planned economies into today’s market economies has been fuelled by the labour of millions of migrant factory workers from rural areas. These countries started reforming at the turn of the 1980s, embracing marketisation while remaining under the Communist party’s political monopoly, a system now commonly termed market socialism. In what seems to be a reversal of the wider trends of austerity, there has been rapid expansion of social protecti",{"id":787,"funder":7,"programme":8,"title":788,"piName":10,"institution":663,"country":435,"year":13,"amount":19,"abstract":789},"cordis-european-research-council-award-850784","Elucidating the development of sexually-dimorphic circuits: from molecular mechanisms to synapses and behavior","In sexually reproducing species, males and females respond to environmental sensory cues and transform the input into sexually dimorphic traits. These dimorphisms are the basis for sex-biased phenotypes in many neurological diseases. Yet, complete understanding of the underlying mechanism is still missing. How does the sexual identity impose molecular changes to individual neurons and circuits? What are the sex-specific synaptic changes that occur during development in these circuits? We recentl",{"id":791,"funder":7,"programme":8,"title":792,"piName":10,"institution":334,"country":246,"year":13,"amount":793,"abstract":794},"cordis-european-research-council-award-851021","Reconstructing cellular histories with transcriptional recording","€1,499,564","What are the main differences between a photograph and a video? Photographs record a single point in time and videos continuously record a sequence of events. While the content and interpretation of a photograph is heavily reliant on a single moment in time, a video is not. The tools that scientists have to understand the molecular and cellular world around them are most like film cameras – producing single snapshots to describe dynamic processes. Towards the goal of continuously recording molec",{"id":796,"funder":7,"programme":8,"title":797,"piName":10,"institution":774,"country":435,"year":13,"amount":417,"abstract":798},"cordis-european-research-council-award-802800","Computing Answers to Complex Questions in Broad Domains","The explosion of information around us has democratized knowledge and transformed its availability forpeople around the world. Still, since information is mediated through automated systems, access is boundedby their ability to understand language.Consider an economist asking “What fraction of the top-5 growing countries last year raised their co2 emission?”.While the required information is available, answering such complex questions automatically isnot possible. Current question answering syst",{"id":800,"funder":7,"programme":8,"title":801,"piName":10,"institution":802,"country":117,"year":13,"amount":803,"abstract":804},"cordis-european-research-council-award-803419","Universal Equilibrium and Beyond - Challenging the Richardson-Kolmogorov Paradigm","DANMARKS TEKNISKE UNIVERSITET","€1,499,036","Turbulence is at a crossroads: The old, established ideas of Richardson and Kolmogorov have with accumulating evidence come under renewed scrutiny, especially in non-stationary and non-equilibrium flows. Many in the community seek new and more accurate ways to describe turbulence. This is a time of re-evaluation and opportunity!The assumed statistical equilibrium of the smallest and intermediate scales is identified as the main cause of the potentially erroneous deductions. This problem was not ",{"id":806,"funder":7,"programme":8,"title":807,"piName":10,"institution":663,"country":435,"year":13,"amount":19,"abstract":808},"cordis-european-research-council-award-849740","Forest belowground carbon transport: From rhizosphere fluxes to physiological drivers","Trees are unique in that responses at the organism level, being upscaled to forest canopies, bear large effects on the cycling and distribution of water and carbon in regional and global scales. Hence, tree carbon allocation dynamics are central not only to tree eco-physiology but also to global biogeochemistry. While tree aboveground carbon fluxes have been extensively studied, belowground fluxes, such as root respiration, growth and exudation have been mostly overlooked due to poor access to t",{"id":810,"funder":7,"programme":8,"title":811,"piName":10,"institution":812,"country":813,"year":13,"amount":814,"abstract":815},"cordis-european-research-council-award-802644","SIGNALING PROPENSITY IN THE MICROENVIRONMENT OF B CELL CHRONIC LYMPHOCYTIC LEUKEMIA","Masarykova univerzita","CZ","€1,499,990","B cell chronic lymphocytic leukemia (CLL) is the most frequent leukemia in adults. CLL cells are characterized by their universal dependency on pro-survival and pro-proliferative signals from immune niches. To achieve this they constantly re-circulate between blood and lymph nodes, which is inhibited by novel microenvironment-targeting therapies such as “BCR inhibitors”. We aim to reveal how the malignant B cells change the propensity of their signalling pathways in response to the different mic",{"id":817,"funder":7,"programme":8,"title":818,"piName":10,"institution":328,"country":282,"year":13,"amount":819,"abstract":820},"cordis-european-research-council-award-802967","Predicting cardiovascular regeneration: integrating mechanical cues and signaling pathways","€1,498,526","The key challenge in regenerative medicine is to re-establish a physiological tissue organization as this is conditional for proper tissue functionality. In the cardiovascular field, tissue engineering of blood vessels and heart valves requires the development of a tri-laminar structure. Previous attempts to establish this organization have been mainly trial-and-error based. Therefore, to force breakthroughs and accelerate clinical translation, computational modeling is critical to understand an",{"id":822,"funder":7,"programme":8,"title":823,"piName":10,"institution":768,"country":97,"year":13,"amount":824,"abstract":825},"cordis-european-research-council-award-802354","Novel NMDA receptor signaling in cortical synaptic depression","€1,340,544","Long-term synaptic plasticity is an experience dependent increase or decrease in synaptic signaling between nerve cells that can last from hours to days or even longer. It is thought to represent the cellular substrate of learning and memory by providing an information storage mechanism in the brain. At many excitatory synapses, plasticity-induction processes involve NMDA receptors, glutamate-gated ion channels. I recently discovered a new form of NMDA receptor signaling during spike-timing depe",{"id":827,"funder":7,"programme":8,"title":828,"piName":10,"institution":829,"country":352,"year":13,"amount":830,"abstract":831},"cordis-european-research-council-award-802653","Acute oxygen sensing and oxygen tolerance in C. elegans","UMEA UNIVERSITET","€1,485,000","Oxygen (O2) levels can vary enormously in the environment, which induces dramatic behavioral and physiological changes to resident animals. Adaptations to O2 variations can be either acute or sustained. How animals detect and respond to the changes of O2 availability remains elusive at the molecular level. In particular, what is the precise mechanism of acute O2 sensing, what are the primary sensor for acute hypoxia, and why do neurons of various species exhibit completely different sensitivity ",{"id":833,"funder":7,"programme":8,"title":834,"piName":10,"institution":835,"country":435,"year":13,"amount":836,"abstract":837},"cordis-european-research-council-award-802774","Information Extraction for Everyone","BAR ILAN UNIVERSITY","€1,499,354","Staggering amounts of information are stored in natural language documents, rendering them unavailable to data-science techniques. Information Extraction (IE), a subfield of Natural Language Processing (NLP), aims to automate the extraction of structured information from text, yielding datasets that can be queried, analyzed and combined to provide new insights and drive research forward.Despite tremendous progress in NLP, IE systems remain mostly inaccessible to non-NLP-experts who can greatly b",{"id":839,"funder":7,"programme":8,"title":840,"piName":10,"institution":511,"country":12,"year":13,"amount":841,"abstract":842},"cordis-european-research-council-award-847873","Neural adaptations during pregnancy","€1,494,393","An expectant mother’s brain undergoes dramatic structural remodeling during pregnancy. These changes are thought to be elicited by hormones, orchestrating the behavioural and physiological adaptations necessary for infant care. Despite the scale of these effects, we know little about the neural mechanisms by which pregnancy affects the brain. Recent methodological advances now offer the exciting opportunity to address these questions. This project will use a multidisciplinary approach to uncover",{"id":844,"funder":7,"programme":8,"title":845,"piName":10,"institution":846,"country":282,"year":13,"amount":847,"abstract":848},"cordis-european-research-council-award-804089","Reshaping cortical circuits to decrease binge eating","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","€1,499,966","Obesity and eating disorders are critical problems in society. Many patients with these brain diseases cope with stress by ravenous food intake (binge eating), which engenders new stress and maintains the pathology. Evidence-based treatments for this are urgently needed, but their implementation is hindered by a knowledge gap on: (i) which stress-driven neural disruptions cause binge eating, and (ii) whether these neural circuit changes can be normalized for therapeutic gain. Studies in humans a",{"id":850,"funder":7,"programme":8,"title":851,"piName":10,"institution":852,"country":97,"year":13,"amount":853,"abstract":854},"cordis-european-research-council-award-803370","Cracking the neural code of human object vision","FREIE UNIVERSITAET BERLIN","€1,480,576","At each blink of our eyes, our brain rapidly transforms the stream of photons hitting the retina into a conscious percept of the world as consisting of meaningful objects that guide our actions to ensure survival. Yet, in spite of intense research three interrelated, fundamental, long-standing and open questions about how neural dynamics mediate object recognition remain unanswered: How exactly do the core cortical regions active during vision represent objects? How and what do those regions com",{"id":856,"funder":7,"programme":8,"title":857,"piName":10,"institution":663,"country":435,"year":13,"amount":858,"abstract":859},"cordis-european-research-council-award-803084","Pathwise methods and stochastic calculus in the path towards understanding high-dimensional phenomena","€1,308,188","Concepts from the theory of high-dimensional phenomena play a role in several areas of mathematics, statistics and computer science. Many results in this theory rely on tools and ideas originating in adjacent fields, such as transportation of measure, semigroup theory and potential theory. In recent years, a new symbiosis with the theory of stochastic calculus is emerging.In a few recent works, by developing a novel approach of pathwise analysis, my coauthors and I managed to make progress in se",{"id":861,"funder":7,"programme":8,"title":862,"piName":10,"institution":863,"country":166,"year":13,"amount":864,"abstract":865},"cordis-european-research-council-award-804095","Optimal Transport Networks in Spatial Equilibrium","Centre de Recerca en Economia Internacional (CREI)","€887,500","Every year, the world economy invests a large amount of resources to improve or develop transport infrastructure. How should these investments be allocated to maximize social welfare? In this proposal, I  propose to develop and apply new methods to study optimal transport networks in general-equilibrium models of international trade, urban economics and economic geography. The methodology will build on recent work (Fajgelbaum and Schaal, 2017), in which my coauthor and I studied the network desi",{"id":867,"funder":7,"programme":8,"title":868,"piName":10,"institution":869,"country":97,"year":13,"amount":870,"abstract":871},"cordis-european-research-council-award-803087","Enteric-nervous-system-mediated regulation of intestinal inflammation","CHARITE - UNIVERSITAETSMEDIZIN BERLIN","€1,499,638","Environmental and internal stimuli are constantly sensed by the body’s two large sensory units, the nervous system and the immune system. Integration of these sensory signals and translation into effector responses are essential for maintaining body homeostasis. While some of the intrinsic pathways of the immune or nervous system have been investigated, how the two sensory interfaces coordinate their responses remains elusive. We have recently investigated neuro-immune interaction at the mucosa ",{"id":873,"funder":7,"programme":8,"title":874,"piName":10,"institution":198,"country":199,"year":13,"amount":875,"abstract":876},"cordis-european-research-council-award-805223","Elastic Coordination for Scalable Machine Learning","€1,494,121","Machine learning and data science are areas of tremendous progress over the last decade, leading to exciting research developments, and significant practical impact. Broadly, progress in this area has been enabled by the rapidly increasing availability of data, by better algorithms, and by large-scale platforms enabling efficient computation on immense datasets. While it is reasonable to expect that the first two trends will continue for the foreseeable future, the same cannot be said of the thi",{"id":878,"funder":7,"programme":8,"title":879,"piName":10,"institution":422,"country":12,"year":13,"amount":880,"abstract":881},"cordis-european-research-council-award-804360","Incentive salience in human cognition during health and disorder","€1,458,033","Incentive salience is a form of motivation for reward that is triggered by environmental cues. These come to be ‘wanted’: they create an urge or craving for approach and consumption that influences choice and guides action. Stimuli imbued with incentive salience are thought to become salient, attention-drawing, and impossible to ignore, and a leading theory of addiction proposes that drug stimulation of the brain’s reward system may create intense and abnormal incentive salience for drug-related",{"id":883,"funder":7,"programme":8,"title":884,"piName":10,"institution":328,"country":282,"year":13,"amount":885,"abstract":886},"cordis-european-research-council-award-803421","Rigorous Search Space Reduction","€1,473,020","In our world of big data and theoretically intractable problems, automated preprocessing to simplify problem formulations before solving them algorithmically is growing ever more important. Suitable preprocessing has the potential to reduce computation times from days to seconds. In the last 15 years, a framework for rigorously studying the power and limitations of efficient preprocessing has been developed. The resulting theory of kernelization is full of deep theorems, but it has overshot its ",{"id":888,"funder":7,"programme":8,"title":889,"piName":10,"institution":890,"country":57,"year":13,"amount":891,"abstract":892},"cordis-european-research-council-award-804422","Navigation of a mind-space. The spatial organization of declarative knowledge","UNIVERSITA DEGLI STUDI DI TRENTO","€1,498,644","Your brain is among the most complex existing systems, and it processes every second an amazing amount of data. The most amazing thing, however, is that you get to know some of it.Declarative knowledge, meaning the portion of knowledge that we can consciously access and manipulate, is one of the most enduring mysteries of the human mind. How did it evolve? And what are the mechanisms behind it? One possibility is that the complex neural machinery that mammals evolved to navigate space has been r",{"id":894,"funder":7,"programme":8,"title":895,"piName":10,"institution":896,"country":117,"year":13,"amount":897,"abstract":898},"cordis-european-research-council-award-804503","Explaining Transnational Jihad - Patterns of Escalation and Containment","DANSK INSTITUT FOR INTERNATIONALE STUDIER","€1,499,056","TRANSJIHAD aims at advancing our understanding of one of the greatest contemporary challenges on the international agenda for peace and security, namely the ability of transnational jihadist movements to tap into local conflicts, hence escalating violence. TRANSJIHAD specifically investigates the questions of how jihadist conflicts become transnational and under what circumstances they can be contained. The project also aims at developing an interdisciplinary analytical framework, which combines",{"id":900,"funder":7,"programme":8,"title":901,"piName":10,"institution":10,"country":10,"year":13,"amount":902,"abstract":903},"cordis-european-research-council-award-802605","Forecasting social Impacts of bioDiversity consErvation poLicies In EurOpe","€1,495,786","Designating Protected Areas (PAs) is the most important policy tool for biodiversity conservation. Over 100 new PAs have been established in the past 36 months in European Union territory. However, effective management of PAs is often obstructed by conflicts mainly associated with the social impacts (SIs) imposed on local communities by their establishment. Despite the importance of these SIs there are certain aspects in this field that remain significantly under-researched. There is now an incr",{"id":905,"funder":7,"programme":8,"title":906,"piName":10,"institution":620,"country":199,"year":13,"amount":907,"abstract":908},"cordis-european-research-council-award-802494","400 Million Years of Symbiosis: Host-microbe interactions in marine lucinid clams from past to present","€1,499,561","The widespread recognition that interactions with microbes drive animal health, development and evolution is transforming biology, but we so far understand the underlying mechanisms in very few systems. Considering that virtually every animal on Earth evolved with and among the microbes in its environment, there is still immense potential for discovering fundamentally new mechanisms of interaction among the staggering diversity of animals and their microbial symbionts in nature. The ancient and ",{"id":910,"funder":7,"programme":8,"title":911,"piName":10,"institution":912,"country":166,"year":13,"amount":913,"abstract":914},"cordis-european-research-council-award-805478","Population dynamics and cultural adaptations of the last Neandertals and first Modern humans in inland Iberia: a multi-proxy investigation","UNIVERSIDAD DE ALCALA","€1,387,515","The relations between cultural developments and environmental change among hunter-gatherers are crucial for studying population dynamics during the last glaciation (110,000–11,700 years ago). However, proposing solid interpretations on how climate and environment variability affected the social and techno-economic organisation of hominins, requires robust geoarchaeological, chronological, and palaeoecological evidence. In the Iberian Peninsula, a key area for this period due to its geographic po",{"id":916,"funder":7,"programme":8,"title":917,"piName":10,"institution":626,"country":97,"year":13,"amount":918,"abstract":919},"cordis-european-research-council-award-804710","Safeguarding Cell Fate by Terminal Repression during Development and Disease","€1,761,489","Cell identity and function requires both induction of desired genes and repression of unwanted programs. While master regulators that activate gene networks during development are well characterized, the mechanisms that terminally repress alternative fates remain poorly understood. Within this project, I aim to demonstrate that active terminal repression is a universal mechanism required to prevent loss of cell identity and disease.We recently found that the neuron-specific transcription repress",{"id":921,"funder":7,"programme":8,"title":922,"piName":10,"institution":411,"country":282,"year":13,"amount":923,"abstract":924},"cordis-european-research-council-award-802759","Untangling the Evolution of a Balanced Lethal System","€1,499,869","Natural selection is supposed to keep lethal alleles (dysfunctional or deleted copies of crucial genes) in check. Yet, in a balanced lethal system the frequency of lethal alleles is inflated. Because two forms of a chromosome carry distinct lethal alleles that are reciprocally compensated for by functional genes on the alternate chromosome form, both chromosome forms – and in effect their linked lethal alleles – are required for survival. The inability of natural selection to purge balanced leth",{"id":926,"funder":7,"programme":8,"title":927,"piName":10,"institution":323,"country":97,"year":13,"amount":928,"abstract":929},"cordis-european-research-council-award-805202","Compact and powerful strong-field terahertz light source for exploring water in new regimes","€1,415,417","Ultrafast laser driven sources of few-cycle THz pulses have progressed from being specialized systems to widespread laboratory tools. This has enabled THz time-domain spectroscopy to emerge as a powerful technique for time-resolved studies of the dynamics of many fundamental constituents of matter. Recent progress in the generation of few-cycle THz pulses with electric field strengths exceeding several MV\u002Fcm, has allowed nonlinear THz spectroscopy to open new exciting fields of research.However,",{"id":931,"funder":7,"programme":8,"title":932,"piName":10,"institution":933,"country":352,"year":13,"amount":934,"abstract":935},"cordis-european-research-council-award-804068","The wide-spread bacterial toxin delivery systems and their role in multicellularity","UPPSALA UNIVERSITET","€1,499,765","Bacteria live in environments where resources for growth are scarce and shared with other bacteria. The ability to inhibit the growth of other bacteria is thus favourable and most bacteria use multiple systems for such antagonistic interactions, including delivery of protein toxins to other bacteria (e.g. bacteriocins, type 6 secretion and contact-dependent growth inhibition systems). In addition to their role in competition, all these toxin delivery systems frequently deliver toxins to cells of",{"id":937,"funder":7,"programme":8,"title":938,"piName":10,"institution":829,"country":352,"year":13,"amount":10,"abstract":939},"cordis-european-research-council-award-802631","The effects of unemployment on health of family members","Previous research has investigated the relationship between unemployment and health from a perspective of an isolated individual. HEALFAM takes a novel approach and examines how transition to unemployment triggers diffusion of ill mental and physical health within families. It investigates how becoming unemployed affects health outcomes of partners, children and elderly parents of the unemployed and whether the magnitudes of these influences differ across families and societies. Thus, instead of",{"id":941,"funder":7,"programme":8,"title":942,"piName":10,"institution":393,"country":394,"year":13,"amount":943,"abstract":944},"cordis-european-research-council-award-802933","Quantifying the global patterns and trends of the illegal wildlife trade: from artificial intelligence to financial market analysis","€1,499,900","Illegal wildlife trade is one of the major threats driving the global extinction crisis. Despite political will to halt the problem, the magnitude and scale of illegal wildlife trade have been relatively poorly studied compared to other threats affecting biodiversity conservation. Lack of data and complexities in determining illegal trade volumes and the availability of illegal wildlife products in the marketplace have thus far limited progress in research. The socio-ecological and economic driv",{"id":946,"funder":7,"programme":8,"title":947,"piName":10,"institution":948,"country":246,"year":13,"amount":949,"abstract":950},"cordis-european-research-council-award-804226","Perceptually-Driven Optimizations of Graphics Content for Novel Displays","UNIVERSITA DELLA SVIZZERA ITALIANA","€1,497,302","Displays play a vital role in many professional and personal activities. They are a crucial interface between a user and the digital world in tasks involving visualization and interaction with digital data. The abilities of new display technologies regarding reproduction of important visual cues, such as binocular disparity, accommodation, or motion parallax, outperform the capabilities of methods for optimizing graphics content to match the requirements of particular hardware designs. This lead",{"id":952,"funder":7,"programme":8,"title":953,"piName":10,"institution":458,"country":435,"year":13,"amount":954,"abstract":955},"cordis-european-research-council-award-852780","The Power of Randomness and Continuity in Submodular Optimization","€1,442,690","Submodularity is a fundamental mathematical notion that captures the concept of diminishing returns, and is prevalent in many areas of science and technology. From pollution detection and gang violence reduction, to active influence spreading in social networks (as recent controversial events suggest), submodular maximization directly affects multiple aspects of our daily lives. With a constantly growing number of real-world applications, it is no surprise that combinatorial maximization problem",{"id":957,"funder":7,"programme":8,"title":958,"piName":10,"institution":959,"country":482,"year":13,"amount":960,"abstract":961},"cordis-european-research-council-award-805486","Radio detection of the PeV - EeV cosmic-neutrino flux","VRIJE UNIVERSITEIT BRUSSEL","€1,410,000","With the detection of the high-energy cosmic-neutrino flux by the IceCube neutrino observatory at the South-Pole, IceCube opened the field of neutrino astronomy. Nevertheless, due to the steeply falling energy spectrum, IceCube runs low in statistics at energies above a few PeV. To probe this flux at the highest energies (>PeV), therefore asks for an even larger detection volume than the cubic-kilometer currently instrumented by IceCube. Due to its long attenuation length the radio signal is an ",{"id":963,"funder":7,"programme":8,"title":964,"piName":10,"institution":637,"country":225,"year":13,"amount":19,"abstract":965},"cordis-european-research-council-award-803714","Exposing nature’s view of ligand recognition in ionotropic glutamate receptors","Molecular biology strives for the prediction of function, based on the genetic code. Within neuroscience, this is reflected in the intense study of the molecular basis for ligand recognition by neurotransmitter receptors. Consequently, structural and functional studies have rendered a profoundly high-resolution view of ionotropic glutamate receptors (iGluRs), the archetypal excitatory receptor in the brain. But even this view is obsolete: we don’t know why some receptors recognize glutamate yet ",{"id":967,"funder":7,"programme":8,"title":968,"piName":10,"institution":969,"country":282,"year":13,"amount":19,"abstract":970},"cordis-european-research-council-award-851564","Mechanism of nucleosome assembly during DNA replication","KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW","Proper inheritance of the epigenetic information during cell division controls cell fate decisions, tissues homeostasis and development, ensuring disease avoidance. We have little understanding however of the mechanisms by which epigenetic information, specifically histone post-translational modifications in nucleosomes, are replicated in parallel to the DNA prior to cell division. This process strictly depends on proper nucleosome formation on the newly synthesized DNA strands. Here, I will stu",{"id":972,"funder":7,"programme":8,"title":973,"piName":10,"institution":381,"country":12,"year":13,"amount":974,"abstract":975},"cordis-european-research-council-award-804166","Stochastic Processes on Random Surfaces","€1,489,406","In the last several decades, two canonical theories of random surfaces have emerged.  The first, so-called Liouville quantum gravity (LQG), has its roots in conformal field theory and string theory from the 1980s and 1990s.  The second, so-called random planar maps (RPM), has its roots in combinatorics from the 1960s.  There has been immense progress in recent years in making rigorous sense of LQG, in the study of the large-scale behavior of RPM, and developing connections between them as well a",{"id":977,"funder":7,"programme":8,"title":978,"piName":10,"institution":979,"country":282,"year":13,"amount":19,"abstract":980},"cordis-european-research-council-award-802648","Laser-driven plasma sources of extreme ultraviolet light for nanolithography","STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN","Moore’s law is not dead. Keeping it alive is of significant importance to society and to the economy. The prediction that the number of transistors in computer and memory chips doubles every two years, has pushed innovative, disruptive technologies, enabling the smartphone and driving tomorrow’s green automotive industries. It changes society.The density of elements realized on a chip is defined by one essential step in their production: lithography. Moore’s law thus provides a challenge to scie",{"id":982,"funder":7,"programme":8,"title":983,"piName":10,"institution":984,"country":12,"year":13,"amount":10,"abstract":985},"cordis-european-research-council-award-802281","Rates of Interglacial Sea-level Change, and Responses","UNIVERSITY OF LEEDS","Global sea-level rise is one of our greatest environmental challenges and is predicted to continue for hundreds of years, even if global greenhouse-gas emissions are stopped immediately. However, the range, rates and responses to sea-level rise beyond 2100 are poorly understood. Current models that project sea-level rise centuries into the future have large uncertainties because the recent observations upon which they are based, encompass too limited a range of climate variability. Therefore, it",{"id":987,"funder":7,"programme":8,"title":988,"piName":10,"institution":989,"country":97,"year":13,"amount":990,"abstract":991},"cordis-european-research-council-award-802209","Motif repeats in intrinsically disordered regions of the clathrin mediated endocytosis pathway","FORSCHUNGSVERBUND BERLIN EV","€1,599,809","Linear motifs are short sequence stretches that occur in intrinsically disordered protein regions (IDRs) lacking stable secondary and tertiary structure, and mediate vital interactions within various biological systems. An exemplary system for the presence of IDRs and a high concentration of linear motifs is the clathrin mediated endocytosis machinery of the eukaryotic cell, where a complex interaction network of IDR-rich adaptor proteins enables both protein and lipid interactions. The molecula",{"id":993,"funder":7,"programme":8,"title":994,"piName":10,"institution":995,"country":12,"year":13,"amount":996,"abstract":997},"cordis-european-research-council-award-804051","Low Carbon Action in Ordinary Cities","THE UNIVERSITY OF SHEFFIELD","€1,393,979","The challenge of LO-ACT is to enable low carbon urban development in medium and small cities in rapidly urbanising areas in East, Central and West Africa, South Asia and South East Asia. The majority of emissions in the next century will be emitted by infrastructures that are yet to be built, particularly in rapidly urbanising areas where infrastructure is lacking. Population forecasts suggest that most population growth will take place in small and medium cities. Yet, to date, research on clima",{"id":999,"funder":7,"programme":8,"title":1000,"piName":10,"institution":1001,"country":199,"year":13,"amount":1002,"abstract":1003},"cordis-european-research-council-award-802217","Computational design of novel functions in helical proteins by deviating from ideal geometries","TECHNISCHE UNIVERSITAET GRAZ","€1,499,414","We propose to computationally design novel ligand binding and catalytically active proteins by harnessing the high thermodynamic stability of de novo helical proteins. Tremendous progress has been made in protein design. However, the ability to robustly introduce function into genetically encodable de novo proteins is an unsolved problem. We will follow a highly interdisciplinary computational-experimental approach to address this challenge and aim to:-Characterize to which extent we can harness",{"id":1005,"funder":7,"programme":8,"title":1006,"piName":10,"institution":1007,"country":97,"year":13,"amount":1008,"abstract":1009},"cordis-european-research-council-award-758985","Advancing the non-invasive assessment of brain communication in neurological disease","TECHNISCHE UNIVERSITAT BERLIN","€1,499,875","Pathological communication between different brain regions has been implicated in various neurological disorders. However, the computational tools for assessing such communication from neuroimaging data are not sufficiently developed. The goal of TrueBrainConnect is to establish brain connectivity analysis using non-invasive electrophysiology as a practical and reliable neuroscience tool. To achieve this, we will develop novel signal processing and machine learning techniques that address shortc",{"id":1011,"funder":7,"programme":8,"title":1012,"piName":10,"institution":1013,"country":166,"year":13,"amount":1014,"abstract":1015},"cordis-european-research-council-award-803375","Erasing the superintegron to understand the role of chromosomal integrons in bacterial evolution","UNIVERSIDAD COMPLUTENSE DE MADRID","€1,499,516","Integrons are genetic platforms that enhance bacterial evolvability through the acquisition and stockpiling of new genes encoded in mobile elements named cassettes. They are found in the chromosomes of environmental bacteria but some have acquired mobility through their association to transposons and conjugative plasmids. These mobile integrons (MI) caused the unexpected rise of multidrug resistance that is now a major threat to modern medicine, and are good proof of the adaptive power of integr",{"id":1017,"funder":7,"programme":8,"title":1018,"piName":10,"institution":1019,"country":282,"year":13,"amount":19,"abstract":1020},"cordis-european-research-council-award-802940","Seeing Citrulline: A Molecular Toolbox for Peptidyl Arginine Deiminases","STICHTING RADBOUD UNIVERSITEIT","Roughly 1% of the world’s population is affected by rheumatoid arthritis (RA); a devastating autoimmune disease causing cartilage destruction and bone erosion. Recent evidences suggest that dysregulation of Peptidyl Arginine Deiminase (PAD) levels are associated with the onset of the disease, leading to the production of antibodies targeting the citrullinated neoepitopes. The exact role of each of the PAD isotypes in these pathological processes is unknown and fundamental questions on the intrac",{"id":1022,"funder":7,"programme":8,"title":1023,"piName":10,"institution":458,"country":435,"year":13,"amount":1024,"abstract":1025},"cordis-european-research-council-award-802735","Nonlinear Data and Signal Analysis with Diffusion Operators","€1,260,000","Nowadays, extensive collection and storage of massive data sets have become a routine in multiple disciplines and in everyday life. These large amounts of intricate data often make data samples arithmetic and basic comparisons problematic, raising new challenges to traditional data analysis objectives such as filtering and prediction. Furthermore, the availability of such data constantly pushes the boundaries of data analysis to new emerging domains, ranging from neuronal and social network anal",{"id":1027,"funder":7,"programme":8,"title":1028,"piName":10,"institution":933,"country":352,"year":13,"amount":1029,"abstract":1030},"cordis-european-research-council-award-804286","The unity of scattering amplitudes: gauge theory, gravity, strings and number theory","€1,425,000","Scattering amplitudes are central observables in quantum field theory and provide essential information about the quantum consistency of perturbative gravity. Precise control of the physical and mathematical properties of scattering amplitudes holds the key to long-standing questions on fundamental interactions and the structure of space and time. As a concrete leap in this direction, UNISCAMP addresses predictions in gauge theories, gravity and effective theories through- the efficient computat",{"id":1032,"funder":7,"programme":8,"title":1033,"piName":10,"institution":1034,"country":282,"year":13,"amount":1035,"abstract":1036},"cordis-european-research-council-award-802568","Who gets to live forever? Toward an Institutional Theory on the Decline and Death of International Organisations","UNIVERSITEIT MAASTRICHT","€1,499,977","Many international organisations (IOs) are under significant pressure. The World Health Organization was heavily criticized over its handling of the Ebola outbreak. The United States has not contributed to the UNESCO budget since 2011 and plans to quit in 2018. The United Kingdom is negotiating its exit from the EU and Burundi left the International Criminal Court. The ultimate way for states to show their discontent is to disband IOs: no less than a third of the IOs, created between 1905 and 20",{"id":1038,"funder":7,"programme":8,"title":1039,"piName":10,"institution":1040,"country":12,"year":13,"amount":10,"abstract":1041},"cordis-european-research-council-award-851854","Fundamental understanding of reactive nitrogen in the global upper troposphere","UNIVERSITY COLLEGE LONDON","The upper troposphere (UT), a severely under-researched part of the atmosphere, has profound impacts on global climate, air quality, major atmospheric oxidants, and the protective ozone layer. Key to its influence on the Earth system are reactive nitrogen compounds (collectively NOy). Models, since their inception, have grossly misrepresented observations of UT NOy, hindering application of these models to accurately estimate the impact of humans on climate, the ozone layer, and air quality. The",{"id":1043,"funder":7,"programme":8,"title":1044,"piName":10,"institution":1045,"country":482,"year":13,"amount":1046,"abstract":1047},"cordis-european-research-council-award-801872","How musical rhythm moves humans: functional mechanisms of entrainment and perception-action coupling","UNIVERSITE CATHOLIQUE DE LOUVAIN","€1,494,900","Entrainment to music is a culturally widespread activity with increasingly recognized pro-social andtherapeutic effects. Music powerfully compels us to move to the musical rhythm, showcasing theremarkable ability of humans to perceive and produce rhythmic inputs. However, the underlyingfunctional mechanisms remain unknown. One view, which dates back to Darwin, is that the relevantmechanisms are ancient and anchored in the evolutionary oldest subcortical parts of the brain.However, recent researc",{"id":1049,"funder":7,"programme":8,"title":1050,"piName":10,"institution":434,"country":435,"year":13,"amount":1051,"abstract":1052},"cordis-european-research-council-award-802990","Mediating the Future: The Social Dynamics of Public Projections","€1,499,732","People’s lives, both as individuals and at the collective level, are guided by projections about the future. This project aims to understand the complex processes through which projections about political issues, such as the outcomes and implications of elections, referenda, crises or wars, are formulated and negotiated within and through the media. It develops a new interdisciplinary approach and research tools for studying how projections evolve over time and through the contribution of variou",{"id":1054,"funder":7,"programme":8,"title":1055,"piName":10,"institution":1056,"country":97,"year":13,"amount":1057,"abstract":1058},"cordis-european-research-council-award-804092","Mechanism Engineering of the Oxygen Evolution Reaction","HELMHOLTZ-ZENTRUM BERLIN FUR MATERIALIEN UND ENERGIE GMBH","€1,499,980","I propose innovative strategies to elucidate and engineer the electrocatalytic mechanism of earth-abundant transition metal oxides with the aim of enhancing the low efficiency of the oxygen evolution reaction (OER). Mastering multi-electron reactions such as the OER is critical for the transition from dwindling fossil fuels to ecologically and economically sustainable fuels based on renewable energy. Water is the most abundant source of hydrogen bonds on earth and fuels based on these bonds have",{"id":1060,"funder":7,"programme":8,"title":1061,"piName":10,"institution":620,"country":199,"year":13,"amount":1062,"abstract":1063},"cordis-european-research-council-award-803060","Repetition, Parallelism and Creativity: An Inquiry into the Construction of Meaning in Ancient Mesopotamian Literature and Erudition","€1,494,198","REPAC is a contribution to the intellectual history of Ancient Mesopotamia, one of mankind’s earliest civilizations. The project investigates the relationship between textual form and function in Mesopotamian literature and scholarly compositions. It focuses on exact and variant repetition as a text structuring device and demonstrates that the use of repetition is grounded in a fundamental aspect of the worldview of Mesopotamian learned scribes. REPAC studies literary, magical and mantic texts w",{"id":1065,"funder":7,"programme":8,"title":1066,"piName":10,"institution":631,"country":282,"year":13,"amount":754,"abstract":1067},"cordis-european-research-council-award-852869","Comprehensive anatomical, genetic and functional identification of cerebellar nuclei neurons and their roles in sensorimotor tasks","How does the brain integrate diverse sensory inputs and generate appropriate motor commands? Our cerebellum is a key region for such a sensorimotor processing, empowered by its sophisticated neural computation and constant communication with other brain regions. The well-timed cerebellar information is integrated and funneled to other brain regions through the cerebellar nuclei (CN). Yet, how CN circuitry contributes to the cerebellar control of sensorimotor processing is unclear. My recent work",{"id":1069,"funder":7,"programme":8,"title":1070,"piName":10,"institution":375,"country":97,"year":13,"amount":1071,"abstract":1072},"cordis-european-research-council-award-801980","App-based Learning for Kindergarten Children at Home","€1,499,969","Children’s literacy and mathematical competencies are a critical platform for their successful functioning as individuals in society. However, many children, in particular those with low socio-economic status (SES) backgrounds who may not receive the home support needed to develop to their full potential, are at risk of not reaching sufficient competence levels. The overall aim of this project is to develop innovative computer tablet applications (‘apps’) and test whether the apps support parent",{"id":1074,"funder":7,"programme":8,"title":1075,"piName":10,"institution":718,"country":282,"year":13,"amount":19,"abstract":1076},"cordis-european-research-council-award-804412","Deciphering and targeting the invasive nature of Diffuse Intrinsic Pontine Glioma","Introduction: The ability of a cancer cell to invade into the surrounding tissue is the main feature of malignant cancer progression. Diffuse Intrinsic Pontine Glioma (DIPG) is a paediatric high-grade brain tumour with no chance of survival due to its highly invasive nature.Goal: By combining state-of-the-art imaging and transcriptomics, we aim to identify and target the key mechanisms driving the highly invasive growth of DIPG.Technology advances: Two unique single cell resolution imaging techn",{"id":1078,"funder":7,"programme":8,"title":1079,"piName":10,"institution":1080,"country":394,"year":13,"amount":1081,"abstract":1082},"cordis-european-research-council-award-802825","Enhancers Decoding the Mechanisms Underlying CAD Risk","ITA-SUOMEN YLIOPISTO","€1,498,647","In recent years, genome-wide association studies (GWAS) have discovered hundreds of single nucleotide polymorphisms (SNPs) which are significantly associated with coronary artery disease (CAD). However, the SNPs identified by GWAS explain typically only small portion of the trait heritability and vast majority of variants do not have known biological roles. This is explained by variants lying within noncoding regions such as in cell type specific enhancers and additionally ‘the lead SNP’ identif",{"id":1084,"funder":7,"programme":8,"title":1085,"piName":10,"institution":1086,"country":394,"year":13,"amount":506,"abstract":1087},"cordis-european-research-council-award-803937","Interacting with Active Particles","AALTO KORKEAKOULUSAATIO SR","Active particles refer to out-of-equilibrium self-propulsive objects such as biological microswimmers and engineered colloidal particles that can form various fascinating collective states. Active particles are easy to observe experimentally but notoriously difficult to interact with due to their fast and stochastic dynamics at both single-particle and collective state levels. In this project, I aim at scientific breakthrough in both instrumentation that allows direct interaction with active par",{"id":1089,"funder":7,"programme":8,"title":1090,"piName":10,"institution":1019,"country":282,"year":13,"amount":1091,"abstract":1092},"cordis-european-research-council-award-804985","The Digital Disruption of Health Research and the Common Good. An Empirical-Philosophical Study","€1,323,473","In the last three years, every major consumer technology company has moved into the health research domain. We are witnessing a digital disruption of health research, or a “Googlization of health research” (GHR). This project will be the first wide-ranging, interdisciplinary study of GHR. Its aim is to develop a normative framework for personal health data governance in this setting, where digital health and digital capitalism, and codes of research ethics and the lawlessness of the Internet eco",{"id":1094,"funder":7,"programme":8,"title":1095,"piName":10,"institution":643,"country":282,"year":13,"amount":1096,"abstract":1097},"cordis-european-research-council-award-801653","The normalisation of natural philosophy: how teaching practices shaped the evolution of early modern science","€1,480,611","Early modern natural philosophy underwent dramatic transformations that completely reshaped its conceptual framework and set of practices. The main contention of my ERC project is that teaching practices had a decisive and ‘normalising’ impact on the progressive dissemination, adaptation and selection of rival conceptions of natural philosophy. Normalisation occurs when historical actors collectively present certain tenets as crucial for the study of a discipline, and thus prescribe them as a ne",200,{"programme":8,"total":1100,"withPiName":1101,"firstYear":1102,"lastYear":1103,"countryCount":1104,"perYear":1105,"topInstitutions":1163,"topCountries":1233},7919,572,2008,2027,52,[1106,1108,1111,1114,1117,1120,1123,1126,1129,1132,1135,1138,1140,1143,1146,1149,1152,1155,1158,1161],{"year":1102,"count":1107},279,{"year":1109,"count":1110},2009,157,{"year":1112,"count":1113},2010,302,{"year":1115,"count":1116},2011,447,{"year":1118,"count":1119},2012,524,{"year":1121,"count":1122},2013,456,{"year":1124,"count":1125},2014,297,{"year":1127,"count":1128},2015,366,{"year":1130,"count":1131},2016,376,{"year":1133,"count":1134},2017,419,{"year":1136,"count":1137},2018,582,{"year":13,"count":1139},393,{"year":1141,"count":1142},2020,384,{"year":1144,"count":1145},2021,394,{"year":1147,"count":1148},2022,514,{"year":1150,"count":1151},2023,512,{"year":1153,"count":1154},2024,473,{"year":1156,"count":1157},2025,482,{"year":1159,"count":1160},2026,556,{"year":1103,"count":1162},6,[1164,1166,1169,1172,1174,1177,1180,1183,1186,1189,1192,1194,1197,1200,1203,1206,1209,1212,1214,1216,1219,1221,1224,1227,1230],{"name":1165,"count":1145},"Centre National de la Recherche Scientifique CNRS",{"name":1167,"count":1168},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",175,{"name":1170,"count":1171},"University of Cambridge",129,{"name":1173,"count":1171},"University of Oxford",{"name":1175,"count":1176},"Hebrew University of Jerusalem",112,{"name":1178,"count":1179},"University College London",110,{"name":1181,"count":1182},"Tel Aviv University",107,{"name":1184,"count":1185},"Weizmann Institute of Science",104,{"name":1187,"count":1188},"Eidgenoessische Technische Hochschule Zuerich",87,{"name":1190,"count":1191},"Kobenhavns Universitet",85,{"name":1193,"count":1191},"Universiteit Gent",{"name":1195,"count":1196},"Universiteit van Amsterdam",84,{"name":1198,"count":1199},"École Polytechnique Fédérale de Lausanne",83,{"name":1201,"count":1202},"Ludwig-Maximilians-Universitaet Muenchen",82,{"name":1204,"count":1205},"Institut National de la Sante Et de la Recherche Medicale",78,{"name":1207,"count":1208},"Universiteit Utrecht",76,{"name":1210,"count":1211},"Imperial College of Science Technology and Medicine",71,{"name":1213,"count":1211},"Katholieke Universiteit Leuven",{"name":1215,"count":1211},"Technische Universiteit Delft",{"name":1217,"count":1218},"Technion - Israel Institute of Technology",70,{"name":1220,"count":1218},"Technische Universitaet Muenchen",{"name":1222,"count":1223},"Universiteit Leiden",69,{"name":1225,"count":1226},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",67,{"name":1228,"count":1229},"The University of Edinburgh",64,{"name":1231,"count":1232},"Helsingin Yliopisto",57,[1234,1236,1238,1240,1242,1243,1245,1247,1249,1251,1253,1255,1257,1259,1260,1262,1264,1267,1269,1271,1273,1276,1279,1282,1285],{"name":97,"count":1235},1346,{"name":12,"count":1237},1007,{"name":75,"count":1239},932,{"name":282,"count":1241},772,{"name":57,"count":1151},{"name":166,"count":1244},475,{"name":435,"count":1246},470,{"name":246,"count":1248},389,{"name":482,"count":1250},348,{"name":352,"count":1252},291,{"name":199,"count":1254},269,{"name":117,"count":1256},189,{"name":394,"count":1258},137,{"name":259,"count":1179},{"name":225,"count":1261},108,{"name":30,"count":1263},92,{"name":1265,"count":1266},"GB",68,{"name":657,"count":1268},60,{"name":813,"count":1270},43,{"name":532,"count":1272},41,{"name":1274,"count":1275},"US",36,{"name":1277,"count":1278},"HU",32,{"name":1280,"count":1281},"TR",24,{"name":1283,"count":1284},"SI",14,{"name":68,"count":1286},10]