[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-starting-grant-2021":3,"awarded-stats-erc-starting-grant":1123},{"awarded":4,"total":1122},[5,16,21,28,33,40,45,50,57,63,68,74,80,85,92,96,101,108,112,117,122,129,134,139,144,149,154,159,164,170,176,182,187,192,198,204,210,216,221,226,231,236,241,247,252,258,263,268,273,278,282,287,292,297,302,306,311,315,320,327,332,337,342,349,356,362,368,373,379,386,392,398,403,409,416,422,428,434,440,446,453,458,465,470,476,482,488,494,499,505,511,516,522,527,533,539,544,548,554,559,565,571,577,582,587,593,599,605,611,616,622,629,634,641,646,652,658,664,670,677,684,689,695,700,706,710,716,722,728,734,739,744,749,754,760,765,771,777,782,788,793,799,804,810,815,821,827,832,837,843,849,855,861,867,872,878,883,888,894,899,904,909,914,920,926,931,936,942,947,953,958,964,971,976,981,987,992,997,1003,1009,1015,1019,1024,1029,1034,1040,1046,1052,1058,1064,1069,1075,1080,1084,1088,1094,1099,1105,1110,1116],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-949583","European Research Council","ERC Starting Grant","Foundations of Motivic Real K-Theory",null,"CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","FR",2021,"€1,331,091","Quadratic forms are ubiquitous throughout mathematics, playing a fundamental role in areas from arithmetic through algebra and geometry. In surgery theory, quadratic forms feature prominently in the classification of smooth manifolds in a given homotopy type, while in arithmetic geometry they can be used to encode Galois and motivic cohomology classes via Milnor's conjecture. The theory of quadratic forms is naturally very sensitive to the prime 2. While in surgery theory this effect is critical",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":11,"country":12,"year":13,"amount":19,"abstract":20},"cordis-european-research-council-award-948674","GENETIC AND ENVIRONMENTAL BASIS OF NATURAL TRANSPOSITION AND ITS POTENTIAL TO CREATE ADAPTIVE VARIATION","€1,499,627","Transposable elements (TEs) are powerful engines of genome evolution, as illustrated by their implication in the rewiring of regulatory networks and the creation of new cellular functions. Short-term consequences of TE mobilization can also be particularly dramatic given that TE insertions are a unique source of large effect mutations. However, there is a lack of knowledge about the contribution of ongoing transposition to within-species variation. This situation stems in large part from the rep",{"id":22,"funder":7,"programme":8,"title":23,"piName":10,"institution":24,"country":25,"year":13,"amount":26,"abstract":27},"cordis-european-research-council-award-948264","An Intersectional Analysis of Ancient Jewish Travel Narratives","AARHUS UNIVERSITET","DK","€1,368,977","ANINAN investigates literary and cultural representations of travel and mobility  the often temporary move of a person from her or his home to another location  in ancient Israelite\u002FJewish narratives, including selected texts of the Hebrew Bible and other Jewish writings from the Hellenistic and early Roman eras (ca. 300 BCE  100 CE). The sources, which originate from different parts of the Mediterranean region, are written or preserved in Hebrew, Aramaic, Greek, Latin, and Geez.The aim is to un",{"id":29,"funder":7,"programme":8,"title":30,"piName":10,"institution":24,"country":25,"year":13,"amount":31,"abstract":32},"cordis-european-research-council-award-948838","Illusions in the thermo-nociceptive system","€1,499,918","What does it mean to experience an illusion of pain? The typical role of pain is to signal when the body is damaged. However, pain illusions in the absence of any risk of tissue damage are common in the normal population. For example, a mix of warm and cold stimuli can be perceived as burning hot, as in the case of the Thermal Grill Illusion. So far, research on thermosensation and pain has largely treated pain illusions as curious quirks of the thermo-nociceptive system, and underplayed the fac",{"id":34,"funder":7,"programme":8,"title":35,"piName":10,"institution":36,"country":37,"year":13,"amount":38,"abstract":39},"cordis-european-research-council-award-949807","Exploring the Limits of Mass Transport in Electro-Chemical Energy Converters ThRough uncOnstrained Design and Interface Engineering","TECHNISCHE UNIVERSITAET MUENCHEN","DE","€1,500,000","A promising option to store and transport clean energy are electrochemical fuels that can be converted to electricity on demand. Fuel cells, electrolysers and flow batteries are used for conversion to and from fuel and have advantages over batteries as storage capacity is cell size independent. Reactant and product transport set the maximum current density obtainable determined by the interplay between multiphase and opposing vapor and liquid flow. To understand this limit, a better way of contr",{"id":41,"funder":7,"programme":8,"title":42,"piName":10,"institution":36,"country":37,"year":13,"amount":43,"abstract":44},"cordis-european-research-council-award-947630","Flow network morphology as memory map: Principles of fluid flow driven dynamic memory in living tubular networks","€1,499,905","Fluid flows through tubular networks are crucial for life as they are the dominant means of substance and signal transport. In living networks – across organisms as disparate as animals and fungi, alterations of flows drive dynamic adaptation of tube diameters which in turn alters transport performance. In effect, local transient stimuli that affect flows are memorized as long-lived alterations to tube diameters across the network. I aim to identify the physical principles behind fluid flows dri",{"id":46,"funder":7,"programme":8,"title":47,"piName":10,"institution":36,"country":37,"year":13,"amount":48,"abstract":49},"cordis-european-research-council-award-949279","High-Energy Physics at the Frontier with Mathematics","€1,502,483","The discovery of the Higgs boson at the LHC has confirmed the Standard Model of Particle Physics up to the highest energies ever tested in a laboratory. The Standard Model is based on a rich mathematical framework, Quantum Field Theory. Among the most powerful instruments to extract precise theoretical predictions for physical observables in Quantum Field Theory are the so-called scattering amplitudes: remarkably involved mathematical objects which encapsulate the probabilities of particle colli",{"id":51,"funder":7,"programme":8,"title":52,"piName":10,"institution":53,"country":54,"year":13,"amount":55,"abstract":56},"cordis-european-research-council-award-950692","Constraining cosmic antinuclei fluxes for indirect dark matter searches with precision measurements of rare antimatter cluster formation","ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA","IT","€1,468,625","Visible matter constitutes only 5% of the matter-energy content of the Universe, whereas the remaining 95% is constituted by unknown forms of matter (20%) and energy (75%) that appear as ``dark'' to us. In the landscape of Dark Matter searches, antinuclei are a promising, almost background-free smoking gun signal for WIMPs and are a target of indirect dark matter searches. This project attacks in a systematic and comprehensive way the modelling of light antimatter cluster formation, necessary to",{"id":58,"funder":7,"programme":8,"title":59,"piName":10,"institution":60,"country":54,"year":13,"amount":61,"abstract":62},"cordis-european-research-council-award-949417","The chemical consequences of vapour loss during planetary accretion","CONSIGLIO NAZIONALE DELLE RICERCHE","€1,600,232","Planets have long been thought to be made from building blocks of primitive (chondritic) meteorites. Yet it has become increasingly clear that such models fail to reproduce the composition of the best constrained planet, Earth. Problematically, no combination of chondritic meteorites can simultaneously explain Earth’s major element composition and isotopic characteristics. This striking dilemma points to the need for a radical reassessment of the current paradigm of planet formation. A tacit ass",{"id":64,"funder":7,"programme":8,"title":65,"piName":10,"institution":11,"country":12,"year":13,"amount":66,"abstract":67},"cordis-european-research-council-award-949208","The evolutionary epidemiology of commensal bacteria: the case of Escherichia coli from 1980 to 2025","€1,499,893","Understanding the rapid adaptation of infectious pathogens is crucial to design better management policies and anticipate future changes. Yet, existing models often fail to explain these dynamics. I will address this major challenge of evolutionary biology in the bacterial species Escherichia coli. E. coli is a commensal of the human gut and an opportunistic pathogen causing infections responsible for more than a million deaths worldwide per year. E. coli has rapidly evolved over the last four d",{"id":69,"funder":7,"programme":8,"title":70,"piName":10,"institution":71,"country":12,"year":13,"amount":72,"abstract":73},"cordis-european-research-council-award-949631","Spatiotemporal control of neuroinfection by meningeal macrophages","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","€1,912,500","Due to the vital importance of the Central Nervous System (CNS), its infection and inflammation have to be tightly controlled. The surface of the CNS is connected to the periphery by a rich and complex tissue, the meninges. They contain a vast network of macrophages subdivided in two populations endowed with elusive functions. Using innovative depletion strategies in experimental mouse models, I discovered that meningeal macrophage populations represent the first line of protection against neuro",{"id":75,"funder":7,"programme":8,"title":76,"piName":10,"institution":77,"country":12,"year":13,"amount":78,"abstract":79},"cordis-european-research-council-award-948135","Ecogenomics of Mosquito-Microbe Symbiosis for Novel Control Strategies of Infectious Diseases","INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT","€1,499,405","The burden of mosquito-transmitted diseases such as Plasmodium, Dengue, West Nile, Zika, Usutu, or yellow fever continue to increase globally, representing one of the most significant public health threats. In the context of insecticide resistance concomitant to the absence of an efficient vaccine, new strategies that focus on mosquito’s microbiota are being developed. In particular the widespread intracellular bacterium Wolbachia, which can limit pathogen transmission and hijack host reproducti",{"id":81,"funder":7,"programme":8,"title":82,"piName":10,"institution":77,"country":12,"year":13,"amount":83,"abstract":84},"cordis-european-research-council-award-948514","Edge-based mechanisms coordinating cell wall assembly during plant morphogenesis","€1,499,771","A fundamental question in biology is how multicellular organisms robustly produce organ shapes. The underlying process of morphogenesis involves the integration of biochemical, genetic, and mechanical factors across multiple spatio-temporal scales. In plants, morphogenesis is dominated by the rigid cell wall, which fixes cells in their position. Adjacent cells must therefore coordinate their growth patterns, which are in turn controlled by the mechanical properties of the cell wall. Cell walls a",{"id":86,"funder":7,"programme":8,"title":87,"piName":10,"institution":88,"country":89,"year":13,"amount":90,"abstract":91},"cordis-european-research-council-award-853516","An integrative approach to unravel the ocean's biological carbon pump","UNIVERSITEIT GENT","BE","€1,997,651","The ocean’s biological carbon pump plays a crucial role in storing atmospheric carbon dioxide in the deep ocean, thereby isolating carbon from the atmosphere for decades to centuries. Yet, its capacity to do so is under-constrained and its mechanisms poorly understood. CarbOcean will develop a mechanistic and quantitative understanding of the biological carbon pump using a novel integrative approach that accounts for its two component pumps: (1) the organic carbon pump, which concerns the photos",{"id":93,"funder":7,"programme":8,"title":94,"piName":10,"institution":53,"country":54,"year":13,"amount":38,"abstract":95},"cordis-european-research-council-award-949722","Leading the first data revolution in European agriculture: farm accountancy data and their impact 1870-1945","Long before Big Data invaded the countryside with datafication and High Precision Farming in the 2010s, at least another data-revolution had taken place in Europe. The spread of bookkeeping to ordinary farmers that started in the second half of the 19th century represents a revolutionary phenomenon whose importance and magnitude have been underestimated by historians. After overseas competition hit European farmers in the 1870s, the diffusion of bookkeeping techniques among ordinary European far",{"id":97,"funder":7,"programme":8,"title":98,"piName":10,"institution":53,"country":54,"year":13,"amount":99,"abstract":100},"cordis-european-research-council-award-950084","Numerical Restoration of Historical Musical Instruments","€1,497,265","The conservation, restoration and maintenance of rare and precious musical instruments is currently problematic, and will become increasingly so in the future: most instruments in museum collections are already out of playing condition, and deteriorating to the extent that their unique sounds will eventually be lost. Curators are well aware of the ethical problems associated with restoration and maintenance, and digital technology offers a solution to the problem of saving the sound of historica",{"id":102,"funder":7,"programme":8,"title":103,"piName":10,"institution":104,"country":105,"year":13,"amount":106,"abstract":107},"cordis-european-research-council-award-949052","Magnetic Insulators: An Enabling Platform for Innovative Spintronic Concepts","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","ES","€1,916,585","New approaches to write, read, and process data are required in order to improve the sustainability of computer technologies. Spintronics offers attractive solutions to these problems. Today, however, the majority of spintronic devices and research efforts rely on a limited set of materials, mostly magnetic conductors. Here I propose to challenge this conventional approach and place magnetic insulators at the core of spintronics by exploiting their advantages over conducting magnets.Magnetic con",{"id":109,"funder":7,"programme":8,"title":110,"piName":10,"institution":104,"country":105,"year":13,"amount":38,"abstract":111},"cordis-european-research-council-award-949745","The missing majority: understanding global ocean ecology by revealing the unknown biology of the most abundant marine microbial eukaryotes","Which are the most abundant microbial eukaryotic species in the world’s sunlit oceans, and what roles do they play in global marine ecology? At present, the answers to both of these questions remain largely unknown. Recently, the Tara Oceans expedition conducted a global ribosomal barcode survey of the surface oceans, revealing that, of roughly 500,000 total Operational Taxonomic Units (OTUs), only 89, which were present in every station sampled by Tara, represent half of the total global OTU ab",{"id":113,"funder":7,"programme":8,"title":114,"piName":10,"institution":104,"country":105,"year":13,"amount":115,"abstract":116},"cordis-european-research-council-award-949652","Top down regulation of motivated behaviors by lateral septal integration of cortico-hippocampal inputs","€1,735,375","How does cognition regulate innate “low-level” behaviors? While the cognitive functions of the prefrontal cortex (PFC) and hippocampus have been extensively studied, we know much less about their ability to regulate the activity of the various hypothalamic nuclei controlling motivated behaviors (sociability, aggression, mating, feeding). Living in society nonetheless requires that our past experiences and decision-making exert some degree of control over our “basic” behaviors. The lateral septum",{"id":118,"funder":7,"programme":8,"title":119,"piName":10,"institution":104,"country":105,"year":13,"amount":120,"abstract":121},"cordis-european-research-council-award-948582","Imprints of Magnetic fields in Exoplanets","€1,495,046","The fast-growing sample of thousands of extrasolar planets is unveiling an amazing variety of properties. It represents an opportunity to shed light on long-standing physics and astrobiology issues from a much wider sample than our Solar neighbours, especially for what concerns the still unclear internal structure, only grossly constrained by observable values of mass and\u002For radii. Planetary magnetism and its long-term evolution is currently understood only partially for the Earth, at a lesser e",{"id":123,"funder":7,"programme":8,"title":124,"piName":10,"institution":125,"country":126,"year":13,"amount":127,"abstract":128},"cordis-european-research-council-award-949699","Duality in Market Design: Theory and Applications","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","UK","€1,060,381","Market design uses economic theory to improve the function of real-world marketplaces, such as matching systems and auctions. In many markets, participants trade goods which are indivisible and highly heterogeneous. My focus is on settings in which participants also experience “income effects”. Income effects arise when participants face budget constraints or when transactions substantially affect participants’ wealth. Income effects are present in many important markets: from spectrum licenses ",{"id":130,"funder":7,"programme":8,"title":131,"piName":10,"institution":125,"country":126,"year":13,"amount":132,"abstract":133},"cordis-european-research-council-award-852470","Development of hypothalamic circuits for the control of homeostasis","€1,999,973","Obesity is a significant global burden that is associated with adverse health outcomes. Adults are not alone in their struggles with obesity. Children now accumulate fat at an alarming rate, making childhood obesity a major health problem. Unfortunately, we do not know enough about the pathophysiology of these conditions to propose appropriate prevention strategies and more effective therapeutic approaches. In this ERC StG proposal, our goal is to discover the developmental processes important f",{"id":135,"funder":7,"programme":8,"title":136,"piName":10,"institution":125,"country":126,"year":13,"amount":137,"abstract":138},"cordis-european-research-council-award-947806","Rethinking Employment Law for a world of Algorithmic Management","€1,496,131","Amidst important debates about the gig economy and the automation of jobs, employment law has paid scant attention to the rise of algorithmic management: the increasingly pervasive reliance on monitoring technology and sophisticated algorithms to measure, control, and sanction workers. This poses a fundamental threat to the legal regulation of our labour markets. Automated management allows the exercise of hitherto impossibly granular employer control. At the same time, however, the absence of c",{"id":140,"funder":7,"programme":8,"title":141,"piName":10,"institution":125,"country":126,"year":13,"amount":142,"abstract":143},"cordis-european-research-council-award-950598","EXtending Interface Science To Atmospheric-pressure Reactions","€1,491,265","This project aims to deliver a step change in our understanding of electrode and catalyst interfaces, by pioneering operando measurement capabilities that can reveal the chemistry and structure of functional interfaces under working conditions in liquid and gas environments at atmospheric-pressures and above. We will exploit enclosed reaction cells sealed with X-ray, electron and neutron transparent windows, extending their operation to conditions of temperature and pressure where industrial cat",{"id":145,"funder":7,"programme":8,"title":146,"piName":10,"institution":104,"country":105,"year":13,"amount":147,"abstract":148},"cordis-european-research-council-award-948986","Quantum Fast Spin dynamics addressed by High-Tc superconducting circuits","€1,803,671","Nanoscopic spin excitations in confined geometries open a wide range of opportunities both for fundamental investigations and for applications. However, quantum magnetization dynamics in nanomagnets are still largely unexplored, especially when it comes to non-homogeneous spin configurations. QFaST is aimed at filling this gap by investigating quantum properties of magnetic vortices stabilized in low-damping ferromagnetic microdiscs at millikelvin temperatures. The project will be built upon qua",{"id":150,"funder":7,"programme":8,"title":151,"piName":10,"institution":104,"country":105,"year":13,"amount":152,"abstract":153},"cordis-european-research-council-award-948281","Land animal evolution: genomic landmarks on the path to terrestrial life","€1,499,485","All animals share a common origin: a marine one. To conquer land from marine environments, animals changed radically the way they breath, reproduce, move or smell. And they did it multiple times in the history of Earth, with terrestrial animals massively outnumbering aquatic ones. Understanding terrestrialization is therefore key to comprehending animal biodiversity and biological adaptation. Despite the relevance of such an episode, the genetic underpinnings orchestrating terrestrialization in ",{"id":155,"funder":7,"programme":8,"title":156,"piName":10,"institution":125,"country":126,"year":13,"amount":157,"abstract":158},"cordis-european-research-council-award-948070","Inefficient Decision Making and Female Bargaining Power","€1,470,375","Dominant economic models of household decision-making assume a utopian scenario characterised by cooperation, commitment, and efficiency. While elegant and tractable, a range of common family behaviours fall outside the scope of these frameworks limiting our understanding of households as economic units and their role in helping individuals insure against shocks. Furthermore, the policy prescriptions implied by the standard models can result in harmful unintended consequences if implemented in c",{"id":160,"funder":7,"programme":8,"title":161,"piName":10,"institution":125,"country":126,"year":13,"amount":162,"abstract":163},"cordis-european-research-council-award-948356","Knowledge-First Social Epistemology","€1,469,955","This highly ambitious project proposes a new research programme for social epistemology. Social epistemology investigates the epistemic effects of social interactions: e.g., how we gain knowledge from social sources (others’ testimony, the media), how we should respond to disagreement, how groups (scientific teams, organisations) can know. It is among the most thriving areas in contemporary philosophy. However, there is little agreement concerning the best methodological approach to social epist",{"id":165,"funder":7,"programme":8,"title":166,"piName":10,"institution":167,"country":126,"year":13,"amount":168,"abstract":169},"cordis-european-research-council-award-948373","Taming the reaction dynamics of paramagnetic species","THE UNIVERSITY OF LIVERPOOL","€1,976,275","Radicals are paramagnetic species – atoms or molecules with an unpaired electron – and they are prevalent in gas-phase environments such as the atmosphere, combustion systems and the interstellar medium. In spite of their real-world importance, very few experimental methods can be applied to the precise study of gas-phase radical reactions. This is primarily due to the significant challenges associated with such studies; there are no established methods for generating a pure beam of atomic or mo",{"id":171,"funder":7,"programme":8,"title":172,"piName":10,"institution":173,"country":105,"year":13,"amount":174,"abstract":175},"cordis-european-research-council-award-950180","Provably Efficient Algorithms for Large-Scale Reinforcement Learning","UNIVERSIDAD POMPEU FABRA","€1,493,990","Reinforcement learning (RL) is an intensely studied subfield of machine learning concerned with sequential decision-making problems where a learning agent interacts with an unknown reactive environment while attempting to maximize its rewards. In recent years, RL methods have gained significant popularity due to being the key technique behind some spectacular breakthroughs of artificial intelligence (AI) research, which renewed interest in applying such techniques to challenging real-world probl",{"id":177,"funder":7,"programme":8,"title":178,"piName":10,"institution":179,"country":37,"year":13,"amount":180,"abstract":181},"cordis-european-research-council-award-950219","Deciphering the role of biomechanics  in chronic obstructive pulmonary disease","HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH","€1,499,462","Chronic obstructive pulmonary disease (COPD), a chronic lung disease caused by polluted air, is the 4th most common cause of death worldwide. Adding to alveolar destruction, patients suffer from debilitating shortness of breath due to obstructed and fibrotic airways. Currently, this mechanical damage is considered a by-product of airway inflammation; rarely, however, do anti-inflammatory treatments slow disease progression. New therapies are urgently needed. Recent studies suggest that mechanica",{"id":183,"funder":7,"programme":8,"title":184,"piName":10,"institution":179,"country":37,"year":13,"amount":185,"abstract":186},"cordis-european-research-council-award-950293","Predicting potent drug combinations by exploiting monotherapy resistance","€1,499,991","Personalising treatments based on tumour genetic profiles enables cancer precision medicine. However, treating cancers using targeted therapies often fails due to the emergence of drug resistance. Here, my goal is to use drug high-throughput screens (HTS) combined with computational methods to identify resistance and its biomarkers, and to overcome it with smart drug combinations to empower cancer precision medicine.Identifying resistance in HTS is challenging: dissecting meaningful drug respons",{"id":188,"funder":7,"programme":8,"title":189,"piName":10,"institution":179,"country":37,"year":13,"amount":190,"abstract":191},"cordis-european-research-council-award-949017","Targeting the crosstalk of lipid and glucose metabolism to stop cancer-associated wasting","€1,411,051","Cachexia is the deadly outcome of many late stage cancers. It is characterized by severe wasting of adipose tissue and muscle mass, cardiac dysfunction and systemic inflammation. To date, no prognostic biomarker or efficient treatment against wasting is available, and ultimately 30% of all patients with cancer will die of cachexia. Hence, we have the critical unmet and urgent medical need of developing novel biomarkers and treatment options.Until now, research has focused on targeting either tum",{"id":193,"funder":7,"programme":8,"title":194,"piName":10,"institution":195,"country":12,"year":13,"amount":196,"abstract":197},"cordis-european-research-council-award-851716","Beyond Shannon: Algorithms for optimal information processing","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","€1,492,733","In the road towards quantum technologies capable of exploiting the revolutionary potential of quantum theory for information technology, a major bottleneck is the large overhead needed to correct errors caused by unwanted noise. Despite important research activity and great progress in designing better error correcting codes and fault-tolerant schemes, the fundamental limits of communication\u002Fcomputation over a quantum noisy medium are far from being understood. In fact, no satisfactory quantum a",{"id":199,"funder":7,"programme":8,"title":200,"piName":10,"institution":201,"country":54,"year":13,"amount":202,"abstract":203},"cordis-european-research-council-award-947908","Reliable and cost-effective large scale machine learning","UNIVERSITA COMMERCIALE LUIGI BOCCONI","€1,498,830","In the last decade, machine learning (ML) has become a fundamental tool with a growing impact in many disciplines, from science to industry. However, nowadays, the scenario is changing: data are exponentially growing compared to the computational resources (post Moore's law era), and ML algorithms are becoming crucial building blocks in complex systems for decision making, engineering, science.  Current machine learning is not suitable for the new scenario, both from a theoretical and a practica",{"id":205,"funder":7,"programme":8,"title":206,"piName":10,"institution":207,"country":37,"year":13,"amount":208,"abstract":209},"cordis-european-research-council-award-899981","Multiscale Fluid and Plasma Dynamics using Particles","UNIVERSITY OF STUTTGART","€1,446,125","In the last decades, non-equilibrium effects in fluid and plasma dynamics have become the major topic for the understanding of the physics behind many applications and important industrial fields.These applications include mirco- and nano-technologies along with plasma-based coating processes of nano device fabrication itself, where small dimensions lead to non-eq. effects.But the applications range right up to other key areas, e.g. re-entry flows and flows around satellites, where rarefied gas ",{"id":211,"funder":7,"programme":8,"title":212,"piName":10,"institution":213,"country":126,"year":13,"amount":214,"abstract":215},"cordis-european-research-council-award-948219","Evolution of pro- and eukaryotic commensals within the human gut","QUADRAM INSTITUTE BIOSCIENCE","€1,499,993","The EPYC project will characterize the evolution of long-term human associated eukaryotes and prokaryotes, using colonization patterns in 3 human generations.The gut microbiome is important for human health, supporting nutrition, pathogen defence and immune homeostasis, with more than 200 species inhabiting each human gut. In recent years metagenomics led to notable breakthroughs in describing this microbial diversity, yet 50-90% of species are typically present at too low abundance to be genome",{"id":217,"funder":7,"programme":8,"title":218,"piName":10,"institution":11,"country":12,"year":13,"amount":219,"abstract":220},"cordis-european-research-council-award-948366","Homeostatic Plasticity beyond the critical period","€1,499,698","Fine-tuning of our sensory systems, learning, memory and cognition rely on neuroplasticity, the capability of our brain to change in response to environmental pressures. Neuroplasticity is maximal during development, underlying the peak of our ability to learn in early childhood and also allowing us to adapt to the external world. As we age, the plastic potential of the brain decreases, especially for sensory cortices. The classical view is that the sensory brain becomes hard-wired after the tem",{"id":222,"funder":7,"programme":8,"title":223,"piName":10,"institution":11,"country":12,"year":13,"amount":224,"abstract":225},"cordis-european-research-council-award-949843","Elucidating the phenotypic determinants of hybrid vigour","€1,495,182","How organismal traits are inherited in offspring is a long-standing, open question. Hybrids between unrelated individuals of plants or animals often show greater vigour, disease resistance, and fertility. The genetic mechanisms behind the deviation of hybrids from the parental phenotype have been widely studied. However, hybrid vigour remains difficult to predict qualitatively and quantitatively. A key bottleneck is that it remains difficult to explain why different traits are inherited differen",{"id":227,"funder":7,"programme":8,"title":228,"piName":10,"institution":11,"country":12,"year":13,"amount":229,"abstract":230},"cordis-european-research-council-award-948358","Non-archimedean Mirror Symmetry","€1,481,550","Mirror symmetry is one of the most mysterious dualities in mathematics. Roughly, it predicts that given any Calabi-Yau variety, there exists a mirror Calabi-Yau variety such that a rich list of geometric relations hold between the two, involving Hodge numbers, Gromov-Witten invariants, variation of Hodge structures, Floer homology (Fukaya category), coherent sheaves, stability conditions and so on. Despite continual progress in the subject, a fundamental question remains unclear: to what extent ",{"id":232,"funder":7,"programme":8,"title":233,"piName":10,"institution":11,"country":12,"year":13,"amount":234,"abstract":235},"cordis-european-research-council-award-949730","Artificial quantum materials with photons: many-body physics and topology","€1,499,603","Physical systems featuring strong electronic correlations exhibit fascinating phenomena, as exemplified by high-Tc superconductivity, quantum magnetism or fractional quantum Hall physics. Inspired by these effects, new ideas have emerged to harness strongly correlated phases in artificial quantum materials, and use them as a resource for fundamental science and for quantum technology. Promising approaches for producing quantum devices are found in condensed matter platforms: one can indeed benef",{"id":237,"funder":7,"programme":8,"title":238,"piName":10,"institution":11,"country":12,"year":13,"amount":239,"abstract":240},"cordis-european-research-council-award-948780","A coherent view of Glasses: How coherent x-rays can elucidate the complex dynamics of glasses","€1,486,931","Glasses are mysterious materials. Fundamental blocks in many natural and technological processes, still, their properties keep puzzling a large community of scientists nowadays. Following different experimental routes, materials as diverse as colloidal suspensions, emulsions and viscous liquids can be driven in an out-of-equilibrium state, where they solidify under conditions that still remain unknown. This process, traditionally called glass transition, leads to many intriguing phenomena as the",{"id":242,"funder":7,"programme":8,"title":243,"piName":10,"institution":244,"country":25,"year":13,"amount":245,"abstract":246},"cordis-european-research-council-award-948689","Searching for axion and axion-like-particle dark matter in the laboratory and with high-energy astrophysical observations","SYDDANSK UNIVERSITET","€1,440,763","The nature of dark matter, which makes up more than 80% of the Universe's matter content, remains unknown. Light axions and axion-like particles (ALPs) are well motivated dark-matter candidates that could be detected through their oscillations into photons in the presence of magnetic fields. Here, complementary laboratory and astrophysical searches for dark-matter axions and ALPs are proposed that will cover more than 10 orders of magnitude of possible axion and ALP masses.The astrophysical sear",{"id":248,"funder":7,"programme":8,"title":249,"piName":10,"institution":11,"country":12,"year":13,"amount":250,"abstract":251},"cordis-european-research-council-award-949500","Evolution of neuronal cell types, development and circuitry in the insect visual system: breaking down behavioural evolution into its constituent elements","€1,632,647","One of the holy grails of neuroscience is to understand how complex behaviours arise. However, surprisingly little is known about how behaviours evolve. My proposal will delve into Behavioural Evolution and Development (BehaEvoDevo) in an unbiased and comprehensive way using the insect visual system as a model. The visual system of Drosophila has been described extensively in terms of cell type composition, development, circuitry, and behaviour. My expertise in this system will be the springboar",{"id":253,"funder":7,"programme":8,"title":254,"piName":10,"institution":255,"country":126,"year":13,"amount":256,"abstract":257},"cordis-european-research-council-award-949119","Cold Molecules for Fundamental Physics","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€1,875,750","Laser cooling of atomic gases in a magneto-optical trap (MOT) has revolutionized modern physics. A MOT uses precisely tuned lasers and a magnetic field to cool atoms and trap them. It has enabled the invention of precise instruments, such as atomic clocks, magnetometers, gravimeters and accelerometers. It has also enabled new fundamental research with unprecedented precision and the study of matter dominated by quantum effects. However, there is still potential to push the boundaries of science ",{"id":259,"funder":7,"programme":8,"title":260,"piName":10,"institution":255,"country":126,"year":13,"amount":261,"abstract":262},"cordis-european-research-council-award-949080","Deciphering and Engineering the overlooked but Universal phenomenon of Subpopulations in BIOtechnology","€1,499,998","Microbial bioproduction, despite being considered a paradigmatic sustainable alternative to petroleum-based chemistry, is often limited by low yields and productivities, which prevents commercialisation. It is generally known for all types of cells that genetically identical populations can form metabolically distinct subpopulations. This diversity strongly impairs bioproduction as the presence of low-producer or slow-grower cells reduces overall yields. However, the universal phenomenon of subp",{"id":264,"funder":7,"programme":8,"title":265,"piName":10,"institution":11,"country":12,"year":13,"amount":266,"abstract":267},"cordis-european-research-council-award-949493","Molecular Programming for MicroRNA profiling","€1,499,326","MicroRNAs, a class of transcript responsible for the fine regulation of gene expression, are emerging as promising biomarkers for cancer monitoring (diagnostic, prognostic and prediction of therapy response. The concentration profiling of  stably present  microRNAs from liquid biopsies represents a hopeful opportunity to fight these diseases, enabling large population screening for early cancer appearance and monitoring in real-time the treatment response. However, current microRNA detection met",{"id":269,"funder":7,"programme":8,"title":270,"piName":10,"institution":255,"country":126,"year":13,"amount":271,"abstract":272},"cordis-european-research-council-award-948336","small Scale interlocking mechanisms for Strong and Tough mEtamatEriaL","€1,499,711","Brittleness limits the design and lifetime of some polymeric, metallic, and almost all ceramic materials in both structural and functional engineering applications, from the design of plane engine turbine blades to the newest solid-state electrolyte in batteries. This brittleness is intrinsically present in material composition that cannot plastically deform and make them sensitive to any defect introduced during their fabrication or usage. The goal of this project is to produce small Scale inte",{"id":274,"funder":7,"programme":8,"title":275,"piName":10,"institution":276,"country":54,"year":13,"amount":38,"abstract":277},"cordis-european-research-council-award-949388","Physics-constrained adaptive learning for multi-physics optimization","POLITECNICO DI TORINO","About a hundred trillion bytes of data has been created in the world while reading this sentence. Central to big data is machine learning, which is an automated way of transforming information into empirical knowledge. Machine learning techniques have been applied to some fluid mechanics problems with success, but there are still three big open questions: Do machine learning algorithms scale to engineering configurations? (Are they robust?); Can we gain physical insight into the solutions? (Are ",{"id":279,"funder":7,"programme":8,"title":280,"piName":10,"institution":255,"country":126,"year":13,"amount":38,"abstract":281},"cordis-european-research-council-award-949660","Next-generation Brain-Computer Interfacing to enable intuitive, skilled control","More than 25% of people over the age of 50 suffer a movement disorder; many of them have a functional disability as a result. Intracortical Brain-Computer Interfaces (BCIs) that extract or “decode” the user’s intent based on recordings from tens or hundreds of cortical neurons have enabled paralyzed patients to control computer cursors, robots, or even their own limbs just by modulating their neural activity. Despite these successes, BCI control still falls short compared to natural limb control",{"id":283,"funder":7,"programme":8,"title":284,"piName":10,"institution":11,"country":12,"year":13,"amount":285,"abstract":286},"cordis-european-research-council-award-851793","Tracking Neanderthals in Time and Space: was the “Quina World” the first regional cultural entity in the history of Europe?","€1,869,324","Neanderthals disappeared ~40 000 years ago; although they have received significant public and academic attention, their evolution and behavioural diversity remain little known. Quina Mousterian designates a singular Neanderthal lithic industry; it is often associated with specific, large game seasonal hunting (herds of reindeer). Particular mobility patterns and elaborate carcass processing suggest an image of a complex, intriguing cultural entity. Outside its core area (SW France), Quina Moust",{"id":288,"funder":7,"programme":8,"title":289,"piName":10,"institution":11,"country":12,"year":13,"amount":290,"abstract":291},"cordis-european-research-council-award-852839","Numerical Simulations of the Milky Way's Accretion History","€1,498,750","The second data release of the Gaia satellite has revealed much complexity in the structure and kinematics of stars in the Milky Way than previously appreciated. In the disc, Gaia has shown that our Galaxy is still enduring the effects of a collision that set millions of stars moving like ripples on a pond. In the stellar halo, the data uncovered a large single debris structure pointing to a massive accretion event 10 billion years ago, at a time when the disc was in its infancy. Our basic assum",{"id":293,"funder":7,"programme":8,"title":294,"piName":10,"institution":11,"country":12,"year":13,"amount":295,"abstract":296},"cordis-european-research-council-award-948390","Latin as an Alien Script in the Medieval Latin East","€1,498,768","Most traffic signs in the Middle East today bear city names transcribed in Latin characters, making them familiar to all. It was the opposite in the 7th c. with the Arab conquest and the Hellenisation of the empire. The Latin script disappeared from the monumental graphic landscape of the Eastern Mediterranean. Progressively until the Ottoman expansion, pilgrims, merchants, crusaders from the West re-established hospices, churches, castles, and placed on monuments and artefacts inscriptions and ",{"id":298,"funder":7,"programme":8,"title":299,"piName":10,"institution":11,"country":12,"year":13,"amount":300,"abstract":301},"cordis-european-research-council-award-948007","High Temperature – Small-Scale Sub-Surface Deformation assisted by Oxidation","€2,493,277","Structural materials exposed at high temperatures (650°C-1200°C) and severe loads are prone to both local oxidation-assisted deformation and deformation-assisted surface reactivity. Material evolutions within the sub-surface region affected by oxidation (0.1 to 100 µm deep gradient) generally drive premature damage and the unexpected ruin of bulky structural components. Therefore, assessing the evolutions of the local deformation at the sub-grain scale at high temperature using micro- and mesome",{"id":303,"funder":7,"programme":8,"title":304,"piName":10,"institution":11,"country":12,"year":13,"amount":38,"abstract":305},"cordis-european-research-council-award-948528","Tracing epigenetic evolution of triple-negative breast cancer towards chemo-resistance","The emergence of resistance to chemotherapy and targeted therapies is a major challenge for the treatment of cancer. While several genetic mechanisms driving resistance processes have been discovered, non-genetic mechanisms have also been shown to contribute to drug resistance. Yet, our restricted understanding of epigenetic evolution has so far limited our ability to modulate resistance using epigenetic modifiers. With ChromTrace, our goal is to reconstruct and define the contribution of epigen",{"id":307,"funder":7,"programme":8,"title":308,"piName":10,"institution":11,"country":12,"year":13,"amount":309,"abstract":310},"cordis-european-research-council-award-948319","Bottom-up fabrication of nanostructured silicon-based materials with unprecedented optical properties","€1,499,403","Controlling the crystallinity, form, dimensions and porosity of nano-objects produces remarkable and unique physical properties. Silica (SiO2) is among the most studied nanomaterial, where its morphology can be controlled precisely. The reduced form, silicon (Si), has exceptional properties of interest to batteries, semi-conductors, electronics and optics. If it were possible to control the physical characteristics of silicon nano-objects, a host of applications would become possible in new doma",{"id":312,"funder":7,"programme":8,"title":313,"piName":10,"institution":11,"country":12,"year":13,"amount":38,"abstract":314},"cordis-european-research-council-award-948688","Evolutionary genomics of royalty in Messor hybridogenetic ants","Royalty in social insects is typically environmentally acquired rather than genetically determined. However, this is not the case in an exceptional reproductive system, known as social hybridogenesis. Here, two distinct royal lineages of ants can only produce queens by their own while they need to hybridize to produce workers. Eggs with a pure royal genome are thus genetically fated to become queens while hybrid genomes are fated to become workers. Convergent evolution toward such a baroque repr",{"id":316,"funder":7,"programme":8,"title":317,"piName":10,"institution":11,"country":12,"year":13,"amount":318,"abstract":319},"cordis-european-research-council-award-949812","Integrating processes across scales to understand and predict ecological dynamics in landscapes","€1,499,978","The accelerating loss and fragmentation of natural habitats are major threats to biodiversity, the very foundation of our life-supporting system. High land pressure at the global scale reduces opportunities to preserve large amounts of habitat. Habitat configuration (i.e. spatial arrangement) and matrix resistance (i.e. easiness for animals to move between habitat patches) remain the only possible adjustment variables to sustain biodiversity. What the management of habitat configuration and matr",{"id":321,"funder":7,"programme":8,"title":322,"piName":10,"institution":323,"country":324,"year":13,"amount":325,"abstract":326},"cordis-european-research-council-award-948465","Dissecting the paradox of stasis in evolutionary biology","UNIVERSITETET I OSLO","NO","€1,499,930","There is something deeply disconcerting about the current state of knowledge on rates of morphological evolution across different timescales: Why do most species in the fossil record exhibit negligible morphological change when contemporary populations often respond rapidly to selection? The ROCKS-PARADOX project will address this fundamental question – known as the paradox of stasis – along mutually reinforcing lines of enquiry, by merging theory and data across paleontology and evolutionary bi",{"id":328,"funder":7,"programme":8,"title":329,"piName":10,"institution":323,"country":324,"year":13,"amount":330,"abstract":331},"cordis-european-research-council-award-948964","Dynamic Territory: A Normative Framework for Territory in the Post-Holocene","€1,498,301","Climate change will disrupt current political, societal and economic paradigms. What should a just territorial arrangement be for countries that will partially or totally disappear due to sea level rise, or whose main productive activities—like farming—will be lost due to changed weather patterns? How to think of “locals” and “migrants” in a world where climate refugees are estimated to reach up to one billion by 2050? How should Global Systemic Resources (GSRs), like rainforests, be governed to",{"id":333,"funder":7,"programme":8,"title":334,"piName":10,"institution":323,"country":324,"year":13,"amount":335,"abstract":336},"cordis-european-research-council-award-947681","The changing relationships between digital technologies, DNA and evidence","€1,496,997","The relationship between digital technologies, DNA and evidence is changing so rapidly and profoundly that in-depth and creative analyses of the links between them are urgently needed. Digital innovations within forensic DNA analysis affect the making of DNA evidence. For example, new computer programs create identikit pictures from DNA. At the same time, DNA and evidence-based reasoning also change digital technologies, for example when DNA is used as a storage medium for digital data. Digital ",{"id":338,"funder":7,"programme":8,"title":339,"piName":10,"institution":323,"country":324,"year":13,"amount":340,"abstract":341},"cordis-european-research-council-award-851121","Protection without Ratification? International Refugee Law beyond States Parties to the 1951 Refugee Convention","€1,499,580","Many of the world’s top refugee-hosting countries have neither signed nor ratified the 1951 Refugee Convention. So do international conventions make a difference? The Refugee Convention represents a paradigmatic – and exceptionally timely – test of this theoretical and empirical puzzle, for refugee protection is increasingly politicized and has wide-ranging implications for state sovereignty.The BEYOND project fundamentally reconsiders the impact of international refugee law by developing the fi",{"id":343,"funder":7,"programme":8,"title":344,"piName":10,"institution":345,"country":346,"year":13,"amount":347,"abstract":348},"cordis-european-research-council-award-947307","Making and Breaking Habits","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","IE","€1,499,910","Every minute of every day, our brains habit system is hard at work automating well-practiced actions so our brains can focus on new and more complex challenges. This does not always work to our benefit, however. My research has implicated hyper-expression of habits in a range of compulsive behaviours, from drug addiction to out-of-control spending, binge-eating and obsessive-compulsive rituals. Despite the importance of habits in our lives, there are major gaps in our understanding of how they a",{"id":350,"funder":7,"programme":8,"title":351,"piName":10,"institution":352,"country":353,"year":13,"amount":354,"abstract":355},"cordis-european-research-council-award-949910","Biocatalytic alkylation: fitting enzymes for selective C-C bond formations","TECHNISCHE UNIVERSITEIT DELFT","NL","€1,625,000","Alkylation, in particular carbon-carbon (C-C) bond formation, is one of the most important and challenging synthetic transformations in chemistry. Current chemical approaches for C-alkylation require the use of expensive and toxic transition metals with complex ligands that have limited selectivity. Developing sustainable methods for the controlled formation of C-C bonds with regio- and stereospecificity in high yields has the potential to change organic chemistry and provide access to new molec",{"id":357,"funder":7,"programme":8,"title":358,"piName":10,"institution":359,"country":37,"year":13,"amount":360,"abstract":361},"cordis-european-research-council-award-948112","Advanced spatio-temporal causal inference for climate research","UNIVERSITAET POTSDAM","€1,499,631","CausalEarth is an interdisciplinary project, aiming to improve our understanding of the interdependencies between major drivers (modes) of climate variability by developing novel statistical causal inference methods for both observations and model data. Disentangling the interdependencies of the major modes, such as El Nino Southern Oscillation and the North Atlantic Oscillation, is key to understand regional climate, and essential for process-based climate model evaluation. The modes' interdepe",{"id":363,"funder":7,"programme":8,"title":364,"piName":10,"institution":365,"country":12,"year":13,"amount":366,"abstract":367},"cordis-european-research-council-award-948105","A Bayesian sense of probability in the human brain: Its characteristics, neural bases and functions","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","€1,499,963","Bayesian inference optimally estimates probabilities from limited and noisy data by taking into account levels of uncertainty. I noticed that human probability estimates are accompanied by rational confidence levels denoting their precision; I thus propose here that the human sense of probability is Bayesian. This Bayesian nature constrains the estimation, neural representation and use of probabilities, which I aim to characterize by combining psychology, computational models and neuro-imaging.I",{"id":369,"funder":7,"programme":8,"title":370,"piName":10,"institution":371,"country":353,"year":13,"amount":38,"abstract":372},"cordis-european-research-council-award-947221","Synaptic Switching with Halide Perovskites","STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN","Metal halide perovskites are attracting much attention because they are excellent semiconductors for use in optoelectronic devices such as solar cells, LEDs, and detectors. Next to electrons, these materials also conduct ions efficiently, and both types of conduction are modulated by light. Ion migration is mostly known to have undesirable effects in optoelectronic devices, such as hysteresis, degradation, and phase segregation. However, the interaction of light, electronic conduction and ionic ",{"id":374,"funder":7,"programme":8,"title":375,"piName":10,"institution":376,"country":89,"year":13,"amount":377,"abstract":378},"cordis-european-research-council-award-948170","“tRNA actors” heterogeneity: a new identifier of cancer stem cells","UNIVERSITE DE LIEGE","€1,499,988","Cells integrate internal and external stimuli by continuously adapting their transcription and translation. tRNAs are heterogeneous and highly modified molecules necessary to correctly translate mRNAs into proteins. Even though their discovery goes back to the late 50s, it is only in the last years that their active role in regulating translation has started to be highlighted both in health and disease. Cancer stem cells (CSC) are a small population of transformed cells able to sustain tumor gro",{"id":380,"funder":7,"programme":8,"title":381,"piName":10,"institution":382,"country":383,"year":13,"amount":384,"abstract":385},"cordis-european-research-council-award-949012","Deep multi-scale modelling of electrified metal oxide nanostructures","UPPSALA UNIVERSITET","SE","€1,400,600","One promising solution toward a sustainable society and a green economy is to use metal oxide-based materials. Metal oxides are a class of inorganic materials that have various energy and environmental applications such as heterogeneous catalyst, fuel cell, lithium-ion battery, supercapacitor, water treatment and antimicrobial application. Most metal oxides are synthesized as nanostructures which leads to unique properties and reduced economical costs. The very properties that make the metal oxi",{"id":387,"funder":7,"programme":8,"title":388,"piName":10,"institution":389,"country":37,"year":13,"amount":390,"abstract":391},"cordis-european-research-council-award-948290","Next generation framework for global glacier forecasting","FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN-NUERNBERG","€1,499,950","Worldwide glacier retreat outside the two large ice sheets is increasingly tangible and the associated ice-loss has dominated the cryospheric contribution to sea-level change for many decades. This retreat has also become symbolic for the effects of the generally warming climate. Despite the anticipated importance for future sea-level rise, continuing glacier retreat will affect seasonal freshwater availability and might add to regional water-stress in this century. Here, I envision a novel self",{"id":393,"funder":7,"programme":8,"title":394,"piName":10,"institution":395,"country":89,"year":13,"amount":396,"abstract":397},"cordis-european-research-council-award-948913","Landscape Use and Mobility In EuRopE - Bridging the gap between cremation and inhumation","VRIJE UNIVERSITEIT BRUSSEL","€1,997,812","Movement represents a key feature of an individuals life both now and in the past. How and why people moved in the past can be documented by biogeochemical studies on bone and teeth, and these are at the core of this project. However, in many cases, due to different funerary practices (i.e. cremation and inhumation), the type archaeological skeletal elements available and their state of preservation of is very variable. Characterizing mobility in times where both cremation and inhumation were pr",{"id":399,"funder":7,"programme":8,"title":400,"piName":10,"institution":88,"country":89,"year":13,"amount":401,"abstract":402},"cordis-european-research-council-award-949557","The Yoruba Print Culture: Networks and Modernities, 1852- Present","€1,412,451","The print culture that Europe introduced to the world allowed other cultures to showcase their own modernity. Yoruba people use the words “olaju” (opening of the eye) and “ilosiwaju” (progress) to describe ideas around modernity. Both words have been in use before the arrival of the printing press in Africa, so therefore the idea of modernity for the Yoruba people did not emanate from the project of colonial modernity. There is no study yet that examined how networks of people with shared and so",{"id":404,"funder":7,"programme":8,"title":405,"piName":10,"institution":406,"country":407,"year":13,"amount":38,"abstract":408},"cordis-european-research-council-award-950480","Neural circuit mechanisms of memory destabilization","FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION","CH","Memories can be rendered rewritable through a phenomenon called reconsolidation. The all-limiting step in this memory re-evaluation process is its initiation; the retrieval-dependent destabilization of the memory. However, the understanding of how a stable memory can be switched into a vulnerable but modifiable state is mostly in its infancy. Therefore, I aim to investigate the neural circuit mechanisms underlying retrieval-induced memory destabilization in the tractable fruit fly brain. A prere",{"id":410,"funder":7,"programme":8,"title":411,"piName":10,"institution":412,"country":413,"year":13,"amount":414,"abstract":415},"cordis-european-research-council-award-947288","Electronic Fingerprint Spectroscopy","TECHNISCHE UNIVERSITAET GRAZ","AT","€2,227,875","Solar ultraviolet (UV) radiation is strongly absorbed in our atmosphere and triggers a variety of photo chemical reactions, strongly influencing the earths development. Exact knowledge of the photo chemistry of environmental trace gasses is of paramount importance to understand effects contributing to global warming and to develop strategies for its abatement. Yet, despite the enormous relevance, spectroscopic information in the UV spectral region is scarce mainly owing to the lack of intense UV",{"id":417,"funder":7,"programme":8,"title":418,"piName":10,"institution":419,"country":126,"year":13,"amount":420,"abstract":421},"cordis-european-research-council-award-948525","Highly Instrumented Low Temperature Reaction Chamber","THE UNIVERSITY OF BIRMINGHAM","€2,493,790","In this project, I will build, optimize, and apply a Highly Instrumented Low Temperature Reaction Chamber (HILTRAC) to study organosulfur chemical reactions. This chamber is the first of its kind to couple a uniform supersonic flow (USF) capable of achieving a wide range of cold temperatures (30  250 K) with the unique detection capabilities of an infrared direct frequency comb spectrometer (DFCS). The combination of DFCS with two additional detection methods (laser-induced fluorescence and time",{"id":423,"funder":7,"programme":8,"title":424,"piName":10,"institution":425,"country":37,"year":13,"amount":426,"abstract":427},"cordis-european-research-council-award-950641","Housing, Inequality and Public Policies","UNIVERSITAT ZU KOLN","€1,478,638","In light of rapidly increasing prices of housing, gentrification and increasing regional inequalities within and across cities in many countries, I study the effectiveness of various public policies to counter these challenges. In particular, I will study the efficiency and distributional effects of seven different, commonly used policy instruments directly or indirectly targeted at the housing market: residential property taxes, commercial property taxes, real-estate transaction taxes, capital ",{"id":429,"funder":7,"programme":8,"title":430,"piName":10,"institution":431,"country":126,"year":13,"amount":432,"abstract":433},"cordis-european-research-council-award-947779","Urbanization, everyday life and techno-social differentiation","THE UNIVERSITY OF SHEFFIELD","€1,483,653","The pattern of contemporary, global urbanization is shifting. New geographies are being produced, with uncertain consequences for urban inequality. Vital here is surging investments into New Transnational Trade Routes through planning\u002Foperation of infrastructural corridors that cut across cities and regions, demarcating the futures of hundreds of millions of urban dwellers. Through deployment of advanced technologies, premium networks and high-tech enclaves’ corridors are transforming everyday u",{"id":435,"funder":7,"programme":8,"title":436,"piName":10,"institution":437,"country":37,"year":13,"amount":438,"abstract":439},"cordis-european-research-council-award-950560","Nonequilibrium Terahertz Dynamics of Interacting Quantum Spins: from Novel Driven States towards Coherent Controls","TECHNISCHE UNIVERSITAT DORTMUND","€1,840,898","The study of non-equilibrium dynamics of magnetic degrees of freedom has shown remarkable progress over the past two decades. This is in particular true concerning the understanding of ultrafast magnetization dynamics in classical magnets. In contrast, the field of non-equilibrium spin dynamics of many-body quantum magnetic systems is still in its infancy. Despite a number of ground-breaking recent theoretical proposals, experimental studies in this direction are truly scarce and this research f",{"id":441,"funder":7,"programme":8,"title":442,"piName":10,"institution":443,"country":37,"year":13,"amount":444,"abstract":445},"cordis-european-research-council-award-949184","Revealing the Synapse Architecture and Plasticity by Structural Interactomics","FORSCHUNGSVERBUND BERLIN EV","€1,499,243","Brain function crucially depends on chemical neurotransmission at synapses, while, conversely, synaptic dysfunction underlies neurological and psychiatric disorders. Synapses are composed of more than 2,000 distinct proteins, spatially organized into specialized molecular machineries. During decades of efforts, researchers have acquired a wealth of knowledge on individual key components of the synapse. However, the overall picture of the spatial arrangement, molecular architecture and interactio",{"id":447,"funder":7,"programme":8,"title":448,"piName":10,"institution":449,"country":450,"year":13,"amount":451,"abstract":452},"cordis-european-research-council-award-948840","Bioinspired Composites Strategies for Saving Energy","AKADEMIA GORNICZO-HUTNICZA IM. STANISLAWA STASZICA W KRAKOWIE","PL","€1,694,375","Saving energy together with energy harvesting is demanded by increasing power consumption. The energy industry requires new materials not only for construction but also in cabling infrastructure. Moreover, the trend of portable and small devices causes a significant challenge in heat dissipation technologies. The need for sustainable technology in thermal insulation and cooling solutions to decrease power consumption requires new innovation. My ambition is to bring novel solutions inspired by na",{"id":454,"funder":7,"programme":8,"title":455,"piName":10,"institution":456,"country":126,"year":13,"amount":10,"abstract":457},"cordis-european-research-council-award-947867","Surveillance and Moral Community: Anthropologies of Monitoring in Germany and Britain","KING'S COLLEGE LONDON","Surveillance—the mediated monitoring of human behaviour for some intended purpose—has become part of the structure of European life. As ubiquitous monitoring technologies transform every new relationship that they mediate, there is grave concern that the social gains of past centuries will be lost, as states and large corporations use these technologies to expand and entrench their own power. Scholars of surveillance have been following these developments since the 1970s, but recently have faced",{"id":459,"funder":7,"programme":8,"title":460,"piName":10,"institution":461,"country":462,"year":13,"amount":463,"abstract":464},"cordis-european-research-council-award-949682","Halide perovskite heterostructures based on 2D nanoplates building blocks for next generation optoelectronics","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","IL","€1,872,500","Soaring demand for energy calls for out of the box thinking in research and design of materials to enable technology far beyond todays standards.What would be the perfect material for light mater interaction? What if we could utilize natural processes and assemble such a material, monolayer by monolayer with exquisite control over the resulting electronic structure. HeteroPlates will address these challenges using halide perovskite two dimensional nanoplates as building blocks and test beds for ",{"id":466,"funder":7,"programme":8,"title":467,"piName":10,"institution":88,"country":89,"year":13,"amount":468,"abstract":469},"cordis-european-research-council-award-945945","NanOthermomteRs for THeranostics","€1,491,250","The goal of this project is to develop novel types of multifunctional nanoparticles combining temperature diagnostics and therapy. More specifically we aim at combining thermometry in the physiological range with either drug delivery or photodynamic therapy (PDT) all in a single hybrid nanoparticle constructed from Periodic Mesoporous Organosilica (PMO) with lanthanide inorganic nanoparticles grown inside the pores and\u002For voids of (hollow) PMO particles. For diagnostic purposes temperature measu",{"id":471,"funder":7,"programme":8,"title":472,"piName":10,"institution":473,"country":383,"year":13,"amount":474,"abstract":475},"cordis-european-research-council-award-949050","Show and Tell: Scientific representation, algorithmically generated visualizations, and evidence across epistemic cultures","LUNDS UNIVERSITET","€1,499,788","How do scientists use new kinds of imagery to show what they know, and to convince diverse others to accept the evidence they offer? Images like brain scans and botanical illustrations are central to scientific practice. But today, accessible technologies can create lifelike algorithmically generated images – photo-like pictures made not with lenses but through the manipulation of digital data. These new kinds of images have introduced distinctive challenges to our ability to trust the things we",{"id":477,"funder":7,"programme":8,"title":478,"piName":10,"institution":479,"country":105,"year":13,"amount":480,"abstract":481},"cordis-european-research-council-award-947713","Prospering without growth:  Science, Technology and Innovation in a post-growth era","UNIVERSIDAD DE VIGO","€1,424,375","The feasibility and desirability of endless economic growth is increasingly being questioned by scholars and activists. While envisioning alternative economic models is key to assure the sustainability and wellbeing of present and future generations, few studies have analysed what might be the role of innovation in a post-growth era. Innovating has become the imperative for the survival and expansion of any form of organisation. But this innovate or die mania underpins assumptions  such as techn",{"id":483,"funder":7,"programme":8,"title":484,"piName":10,"institution":485,"country":353,"year":13,"amount":486,"abstract":487},"cordis-european-research-council-award-948601","STOrylines of futuRe extreMes","STICHTING VU","€1,489,442","Future climate projections show a strengthening of the hydrological cycle with more droughts and floods expected. This means a higher likelihood of cascading drought-to-flood disasters such as the Millennium Drought – Brisbane flooding in Australia or the California drought – Oroville spillway collapse in the US. Current research and management treat floods and droughts as independent, which leads to large underestimations of their future risk. Droughts allow ample time for impacts and adaptatio",{"id":489,"funder":7,"programme":8,"title":490,"piName":10,"institution":491,"country":89,"year":13,"amount":492,"abstract":493},"cordis-european-research-council-award-948449","ZEolite synthesis in Unusual Reactors for Enhanced CAtalysts","KATHOLIEKE UNIVERSITEIT LEUVEN","€1,498,500","Approximately 9 out of 10 chemical processes use a solid catalyst, as they increase the efficiency of chemical reactions while being recyclable. Zeolites are one of the most iconic types. These porous crystalline oxides are built from networks of aluminum and silicon nodes and are characterized by regular pores with dimensions similar to most of the molecules that sustain modern society.Although zeolite synthesis is essentially an assembly of silica and alumina around positively charged template",{"id":495,"funder":7,"programme":8,"title":496,"piName":10,"institution":371,"country":353,"year":13,"amount":497,"abstract":498},"cordis-european-research-council-award-948132","Smart fluidic circuits for autonomous soft robots","€1,498,636","Soft robots have the potential to be more robust, adaptable, and safer for human interaction than traditional rigid robots. State-of-the-art developments push these soft robotic systems towards applications such as rehabilitation and diagnostic devices, exoskeletons for gait assistance, and grippers that can handle delicate objects. However, despite these exciting developments, there are two major challenges: (1) existing electronic control, intelligence and power of soft robots is too bulky to ",{"id":500,"funder":7,"programme":8,"title":501,"piName":10,"institution":502,"country":503,"year":13,"amount":38,"abstract":504},"cordis-european-research-council-award-947975","A multi-parametric Regulatory T cell Atlas in cancer to predict immunotherapy response, adverse autoimmune events and to identify novel therapeutic targets","IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON","EL","The advent of immune checkpoint inhibitors (ICI), that target regulatory pathways in T cells to unleash antitumor immune responses, has revolutionized cancer immunotherapy. However, despite the enormous success of ICI in the treatment of cancer, a significant proportion of patients do not respond, while responses are frequently accompanied by life-threatening autoimmune related adverse events (irAEs). Predictive biomarkers of clinical responses and new therapeutic strategies to harness anti-tumo",{"id":506,"funder":7,"programme":8,"title":507,"piName":10,"institution":508,"country":12,"year":13,"amount":509,"abstract":510},"cordis-european-research-council-award-949221","Detection of Early seismic signal using ARtificiaL Intelligence","INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT","€1,499,518","Earthquakes caused nearly one million fatalities in the last two decades. The hazardous nature of earthquakes is largely due to their unpredictability. The question of whether this unpredictability is ontological (i.e. earthquakes are a chaotic phenomenon that physics cannot predict) or a consequence of our incapacity to model them is still open. In the first case, one may never hope to predict earthquakes and efforts should be focused towards developing early-warning approaches so that the popu",{"id":512,"funder":7,"programme":8,"title":513,"piName":10,"institution":514,"country":407,"year":13,"amount":38,"abstract":515},"cordis-european-research-council-award-950319","Evolutionary consequences of novel plant defences","UNIVERSITAT ZURICH","Plant chemical defences play a central role in mediating interactions between plants and their enemies. Phytochemical diversity may be advantageous to reduce herbivore pressure, and plants commonly produce vast numbers of chemicals. However, the diversity of functional classes of defensive chemicals is often more limited and subject to strong phylogenetic constraints. Such functional conservatism may accelerate the evolution of tolerance in specialized herbivores, resulting in plant-herbivore sy",{"id":517,"funder":7,"programme":8,"title":518,"piName":10,"institution":519,"country":126,"year":13,"amount":520,"abstract":521},"cordis-european-research-council-award-949821","Selective Electrochemical Nucleophilic Fluorination","UNIVERSITY OF BRISTOL","€1,553,043","The incorporation of fluorine into organic compounds is extremely important for designing molecules with specific function. Fluorine is primed for improving the pharmacokinetic properties of drugs and agrochemicals, and is crucial for the life-changing imaging technique, Positron Emission Tomography (PET). Thus, selective fluorination is an area of significant interest in organic synthesis.This research programme will develop a concept that promises to revolutionise fluorination chemistry. While",{"id":523,"funder":7,"programme":8,"title":524,"piName":10,"institution":525,"country":462,"year":13,"amount":38,"abstract":526},"cordis-european-research-council-award-948051","Visuality in the Qur'an and Early Islam","THE HEBREW UNIVERSITY OF JERUSALEM","VISIONIS sets out to write a cultural history of vision in Early Islam. It aims to generate a paradigm shift in the understanding of visuality in the transitional period between Late Antiquity and Early Islam. The project argues that the Qur’an is a key locus for our knowledge of the scope of visual strands in the epistemic space of Late Antiquity and the ways in which these visual strands were adapted and transformed by the emerging new religious community of Muslims. It also assumes that Early",{"id":528,"funder":7,"programme":8,"title":529,"piName":10,"institution":530,"country":462,"year":13,"amount":531,"abstract":532},"cordis-european-research-council-award-950533","The Missing Pieces of the SMBH Accretion Puzzle: Revealing Extreme Accretion Modes","TEL AVIV UNIVERSITY","€1,684,750","How do supermassive black holes (SMBHs) turn their accretion “on” and “off”? How fast can they grow? How is this related to their circumnuclear environments? What are the consequences for the emergence of the first SMBHs and their co-evolution with galaxies? The key to answering these and other questions is found in understanding SMBH accretion, in all possible modes and cosmic epochs. Recent progress in both theory and observations strongly support “extreme” modes of SMBH accretion, namely abru",{"id":534,"funder":7,"programme":8,"title":535,"piName":10,"institution":536,"country":353,"year":13,"amount":537,"abstract":538},"cordis-european-research-council-award-949918","Cultures of Suspicion in Post-Socialist Europe","UNIVERSITEIT VAN AMSTERDAM","€1,487,090","Academic inquiry into conspiracy theories is unquestionably on the rise. Since the turn of the millennium, a new generation of scholars has released conspiracy theory from its earlier associations with individual pathologies, and has shifted attention to its wider social and cultural functioning. Notwithstanding these developments, existing research still tends to treat conspiracy theories in historical and cultural isolation, overlooking their reliance on earlier events and narrative templates,",{"id":540,"funder":7,"programme":8,"title":541,"piName":10,"institution":88,"country":89,"year":13,"amount":542,"abstract":543},"cordis-european-research-council-award-900008","Directed networks as a novel approach for improving the management of cardiac arrhythmias","€1,498,125","The management of cardiac arrhythmia remains the largest problem in cardiac electrophysiology. The prevalence of the most frequent arrhythmia, atrial fibrillation (AF), is expected to rise steeply due to the ageing population. In spite of intensive research, the mechanism of atrial fibrillation remains unclear, leading to poor results in its treatment. Ablation of AF often results in complex atrial tachycardia (AT), which are difficult to treat. Also ventricular tachycardias (VT) and fibrillatio",{"id":545,"funder":7,"programme":8,"title":546,"piName":10,"institution":473,"country":383,"year":13,"amount":38,"abstract":547},"cordis-european-research-council-award-949538","The hardships for life to become big  – rethinking hypoxia as an evolutionary driver for the rise of complex multicellularity","Why complex life evolved on Earth has puzzled scientists for as long as sufficient oxygen has been deemed vital. Motivated by recent discoveries, however, this project will investigate the dawning paradox that multicellular life requires low oxygen (hypoxia) internally to thrive in the oxic niche. Central biological mechanisms in animals and plants need protection from oxygen and appears to depend on hypoxic niches. I have previously reconciled geological and medical observations to demonstrate ",{"id":549,"funder":7,"programme":8,"title":550,"piName":10,"institution":551,"country":54,"year":13,"amount":552,"abstract":553},"cordis-european-research-council-award-948590","Cell-inspired particle-based intelligent microrobots","SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA","€1,499,375","Microscale robotic devices, or microrobots, could someday enable revolutionary non-invasive medical procedures. However, fundamental limitations still hinder the realisation of this vision. Current microrobots have very limited functionalities: they strongly rely on wireless operation by external fields, which impedes the execution of sophisticated movements and tasks. As a consequence, despite their intended medical use, microrobots cannot move effectively in bodily fluids and tissues. This pro",{"id":555,"funder":7,"programme":8,"title":556,"piName":10,"institution":557,"country":353,"year":13,"amount":38,"abstract":558},"cordis-european-research-council-award-949059","Using Network Theory to Predict Depression Onset and Build a Personalized Early Warning System","UNIVERSITEIT LEIDEN","Depression is common, debilitating, and often chronic. It severely compromises the capacity for independent living, and is the strongest predictor of suicide. Young people are disproportionately affected, and many will spend over 20% of their lives in a state of depression. Further, only 50% of patients improve under initial treatment. Experts agree that prevention is the most effective way to change depressions global disease burden. The biggest barrier to successful personalized prevention is ",{"id":560,"funder":7,"programme":8,"title":561,"piName":10,"institution":562,"country":462,"year":13,"amount":563,"abstract":564},"cordis-european-research-council-award-947709","Cracking the Code for Protein Quality Control Mechanisms Recognizing Exposed Hydrophobicity in Protein Substrates","BAR ILAN UNIVERSITY","€1,801,490","Proteostasis is a highly regulated process by which cells maintain a healthy proteome. Loss of proteostasis is a common feature of aging and disease. To preserve proteostasis, the cell has developed protein quality control (PQC) pathways that monitor a proteins’s fate from synthesis to degradation. Exposed hydrophobic residues in aberrant or mislocalized protein substrates is a key feature recognized by distinct PQC mechanisms. If not handled properly, exposed hydrophobicity can result in protei",{"id":566,"funder":7,"programme":8,"title":567,"piName":10,"institution":568,"country":37,"year":13,"amount":569,"abstract":570},"cordis-european-research-council-award-949873","Edaphic adaptation in barley wild relatives and its transfer to the domesticate","LEIBNIZ - INSTITUT FUER PFLANZENGENETIK UND KULTURPFLANZENFORSCHUNG","€1,499,928","Wild relatives of domesticated plants have long been recognized as important sources of beneficial traits for crop improvement. Having diverged millions of years ago from the domesticate, they have evolved adaptations to more diverse habitats, potentially representing a much wider genetic diversity than could be captured by intraspecific diversity in a crop and its direct wild progenitor. However, concomitant sequence and karyotype divergence have made crop-wild relatives inaccessible to the cro",{"id":572,"funder":7,"programme":8,"title":573,"piName":10,"institution":574,"country":383,"year":13,"amount":575,"abstract":576},"cordis-european-research-council-award-948727","A Better Life for the Children of Exile: Intergenerational Adaptation of the Descendants of Refugees","STOCKHOLMS UNIVERSITET","€1,406,237","More than 2.5 million refugees have been granted residence in Europe over the last ten years and their long-run adaptation is a fundamental societal challenge. Adaptation can only be evaluated over the long-run by making intergenerational comparisons between immigrants and their descendants, yet research has almost entirely overlooked this topic for refugees, not least because most countries lack both data and significant numbers of descendants of refugees. Prior studies focus on isolated domain",{"id":578,"funder":7,"programme":8,"title":579,"piName":10,"institution":580,"country":407,"year":13,"amount":38,"abstract":581},"cordis-european-research-council-award-950672","Synthetic Lives: The Futures of Mining","FONDATION POUR L INSTITUT DE HAUTES ETUDES INTERNATIONALES ET DU DEVELOPPEMENT","The global extractive industry is undergoing three critical transformations: first, the advent of synthetic or lab-grown minerals, impacting the mining industry and the extraction of resources from nature; second, the creation of fully automated mining operations, seeking to render human work redundant or accessory to that of bots, drones, and other autonomous machines; third, the introduction of digital data and disintermediation technologies for mining management and traceability. Taken togeth",{"id":583,"funder":7,"programme":8,"title":584,"piName":10,"institution":389,"country":37,"year":13,"amount":585,"abstract":586},"cordis-european-research-council-award-945602","Pathogen-responsive hydrogels release antimicrobial vesicles for local infection treatment","€1,499,333","The rise of bacterial resistance against antibiotic drugs is becoming the leading cause for morbidity and mortality worldwide. In Europe alone, up to 33,000 people die each year from infections with resistant bacteria. Current antibiotic therapy often suffers from low selectivity, adverse side effects in other organs and impaired ability to overcome bacterial barriers. These problems limit the efficacy of our antibiotic arsenal. Local and effective eradication of bacterial infections is of utmos",{"id":588,"funder":7,"programme":8,"title":589,"piName":10,"institution":590,"country":37,"year":13,"amount":591,"abstract":592},"cordis-european-research-council-award-950278","Functional and structural studies of the U12-dependent splicing in human cells","EUROPEAN MOLECULAR BIOLOGY LABORATORY","€1,479,277","Introns are non-coding segment of eukaryotic genes, which are removed from precursors of messenger RNAs (pre-mRNAs) by a large and dynamic RNA-protein complex known as the spliceosome. In human cells, most of the introns are processed by the canonical U2-dependent, major spliceosome. Around 0.5% of human introns utilise an alternative splicing pathway, catalysed by the minor spliceosome, which depends on the U12 small nuclear RNA (snRNA). While U12-dependent introns are rare, often they are loca",{"id":594,"funder":7,"programme":8,"title":595,"piName":10,"institution":596,"country":54,"year":13,"amount":597,"abstract":598},"cordis-european-research-council-award-948250","Sub-nanometer quantum engineering of 2D materials for optoelectronic devices","FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA","€1,499,500","Optoelectronic devices are at the core of today’s information revolution, bridging digital electronics and optical fiber telecommunications. However, there is a worrisome disparity in the scaling of global internet traffic (growing at 60% rate every year) and the capacity of the optical network (with growth rate of just 20%). Therefore, there is a need for new miniaturized optoelectronic technologies, and integration on silicon is a must. The objective of this project is to address this issue wi",{"id":600,"funder":7,"programme":8,"title":601,"piName":10,"institution":602,"country":324,"year":13,"amount":603,"abstract":604},"cordis-european-research-council-award-947684","Understanding the causal nature of the relationship between infertility and cardiovascular disease","FOLKEHELSEINSTITUTTET","€1,479,676","The burden of infertility is high across Europe. Modest evidence indicates that infertile couples might have an increased risk of cardiovascular disease (CVD), but several questions need clarification to establish a cause-and-effect relationship. This includes understanding: whether both infertile men and women have an increased risk of CVD; how well-known risk factors for CVD (blood-pressure, body-mass index, cholesterol and smoking) relate to infertility; whether there exists common genetic de",{"id":606,"funder":7,"programme":8,"title":607,"piName":10,"institution":608,"country":413,"year":13,"amount":609,"abstract":610},"cordis-european-research-council-award-947702","Dynamic Algorithms Against Strong Adversaries","PARIS-LODRON-UNIVERSITAT SALZBURG","€1,499,843","From a procedural viewpoint, an algorithm is a list of instructions that transforms a given input into the desired output. While this paradigm has been successfully applied in theory and practice, it completely neglects the fact that in many scenarios the input is not given to the algorithm in its entirety at the beginning and might undergo changes that the algorithm needs to react to. Formally, such a situation can be modeled as a game between an adversary creating the sequence of updates to th",{"id":612,"funder":7,"programme":8,"title":613,"piName":10,"institution":456,"country":126,"year":13,"amount":614,"abstract":615},"cordis-european-research-council-award-851055","Dynamic regulation of tissue response by matrix viscoelasticity","€1,499,989","The mechanical properties of the extracellular matrix (ECM) regulate processes during development, cancer and wound healing. The vast majority of research efforts in this field have been focused on ECM’s elasticity as a leading determinant of cell and tissue behaviour. However, the ECM is not merely elastic but is instead both viscous and elastic. Due to its viscoelastic nature, the ECM response to mechanical loads is inherently dynamic and evolves with time, independently of matrix degradation ",{"id":617,"funder":7,"programme":8,"title":618,"piName":10,"institution":619,"country":407,"year":13,"amount":620,"abstract":621},"cordis-european-research-council-award-947634","A SpectroPhotometric Inquiry of Close-in Exoplanets around the Desert to Understand their Nature and Evolution","UNIVERSITE DE GENEVE","€1,499,956","Half of known exoplanets orbit close to their star, featuring a desert of hot Neptunes whose origins remain uncertain. These planets may have lost their gas atmosphere, eroding into the dust-rich rocky planets found below the desert. Testing this scenario requires deriving accurate mass losses, but a lack of observational tracers prevented us from validating and refining models of escaping atmospheres. The coupling of atmospheric evolution with orbital migration, which can bring planets close to",{"id":623,"funder":7,"programme":8,"title":624,"piName":10,"institution":625,"country":626,"year":13,"amount":627,"abstract":628},"cordis-european-research-council-award-945733","A nationwide artificial intelligence risk assessment for primary prevention of cardiometabolic diseases","HELSINGIN YLIOPISTO","FI","€1,550,057","Diabetes, stroke and coronary artery disease (cardiometabolic diseases) are the leading cause of death in Europe. Given that effective pharmacological and lifestyle interventions are available, it is important to identify high risk individuals at an early stage. Traditionally, this is done using clinical prediction models. However, the established models have substantial limitations: they are often used by doctors only when an underlying disease is already suspected, they are not developed on up",{"id":630,"funder":7,"programme":8,"title":631,"piName":10,"institution":596,"country":54,"year":13,"amount":632,"abstract":633},"cordis-european-research-council-award-948186","Sensorimotor Foundations of Communicative Musicality","€1,499,562","Most human communication relies on experience, with few exceptions, one being music. Communicative musicality – the ability to communicate through music – can cross developmental, linguistic and cultural boundaries. Identifying the foundations of communicative musicality is a question of outstanding importance in cognitive science, as this ability has been suggested to support all human communication. Yet, to date, music is either studied in non-communicative contexts (i.e. with players or liste",{"id":635,"funder":7,"programme":8,"title":636,"piName":10,"institution":637,"country":638,"year":13,"amount":639,"abstract":640},"cordis-european-research-council-award-948152","Note-taking and Notebooks as Channels of Medieval Academic Dissemination across Europe","UNIVERSITATEA BABES BOLYAI","RO","€1,175,100","Note-taking is a common intellectual practice. In academia, it is a universal endeavor that we share with students since the origin of the universities. Yet no one has focused on this practice as an original and independent object of research that, once investigated, will bring innovation and expand our knowledge of European intellectual history. Project NOTA is an ambitious enterprise, rooted in the discovery that decoding medieval notebooks produced in the context of late medieval universities",{"id":642,"funder":7,"programme":8,"title":643,"piName":10,"institution":644,"country":37,"year":13,"amount":38,"abstract":645},"cordis-european-research-council-award-949990","DNA Breaks Shape Neural Genome Heterogeneity","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","Neural progenitor cells undergo tens of thousands of cell divisions to generate the 80 billion neurons in a human brain. In neural progenitor cells, replication stress can lead to recurrent DNA break clusters (RDCs). Joining of two RDC breaks may introduce somatic genomic diversity. On the other hand, unbalanced genomic mosaicism in neural progenitor cells may lead to brain cancer and neuropsychiatric disorders. This proposal will test whether cell-autonomous DNA lesions that accumulate during r",{"id":647,"funder":7,"programme":8,"title":648,"piName":10,"institution":649,"country":346,"year":13,"amount":650,"abstract":651},"cordis-european-research-council-award-950010","Disrupted Circadian Rhythms in Families - an Endophenotype of Autism Spectrum Disorder?","NATIONAL UNIVERSITY OF IRELAND MAYNOOTH","€1,499,323","Sleep disturbances are highly prevalent in children with neurodevelopmental disorders, and this adversely impacts the whole family’s wellbeing. While the origins of neurodevelopmental disorders are considered largely genetic, the mechanisms that underlie sleep disruption, and their relationship to neurodevelopment, is relatively unexplored. Chronotype is our daily preference for morning or evening time, and a recent large-scale genome-wide association study highlighted its significant relationsh",{"id":653,"funder":7,"programme":8,"title":654,"piName":10,"institution":655,"country":462,"year":13,"amount":656,"abstract":657},"cordis-european-research-council-award-949010","A Phenomenological, Computational and Neural model of the Sense of Reality","UNIVERSITY OF HAIFA","€1,498,187","We all rely on our senses to convey veridical information about the world around us, which we call “Reality”. However, distortions of reality in the form of hallucinations or illusions originating from neurological, psychiatric, pharmacological or psychological origins are prevalent. Thus, the sense of reality which is the ability to discriminate between true and false perceptions of the world, is a central criterion for neurological and psychiatric health. Despite the critical role of the sense",{"id":659,"funder":7,"programme":8,"title":660,"piName":10,"institution":661,"country":126,"year":13,"amount":662,"abstract":663},"cordis-european-research-council-award-950402","Photonics for High-Dimensional Quantum Networking","HERIOT-WATT UNIVERSITY","€2,050,758","Humanitys reliance on the rapid and free flow of information cannot be understated. Over the last two decades, control over the spectral, temporal, and spatial structure of light has led to a massive increase in optical data transfer rates via signal multiplexing. For example, the simultaneous encoding of information in 84,236 spatial and frequency channels was recently used for achieving a record 10 Petabit\u002Fsec data transmission rate. As quantum technologies mature, so will the needs of a quant",{"id":665,"funder":7,"programme":8,"title":666,"piName":10,"institution":667,"country":54,"year":13,"amount":668,"abstract":669},"cordis-european-research-council-award-947923","CHallenges in ANalysis and GEometry, between mean and scalar curvature","UNIVERSITA DEGLI STUDI DI TRENTO","€1,342,500","The interplay between Analysis and Geometry has led to a number of spectacular achievements such as the proof of the Poincaré conjecture by Perelman. The goal of this proposal is to establish a research group that will make striking progress along the following two  directions, that reflect the two souls, extrinsic and intrinsic, of Riemannian Geometry, as well as their mutual interaction. Minimal surfaces, namely surfaces of zero mean curvature, have been an object of mathematical study since t",{"id":671,"funder":7,"programme":8,"title":672,"piName":10,"institution":673,"country":674,"year":13,"amount":675,"abstract":676},"cordis-european-research-council-award-947749","Commercial Patterns Across the Sea: The interdisciplinary study of Maritime Transport Containers from Cyprus and the elucidation of Mediterranean connectivity during the Late Bronze Age-Early Iron Age","UNIVERSITY OF CYPRUS","CY","€1,254,300","Ancient ceramic vessels are not merely lumps of clay that were formed and fired to be utilised at some point in the past. They represent vigorous discourses among raw materials, technological knowhow and the societies that produced and used them. In addressing the complexities inherent in archaeological ceramics, we attain an indispensable insight into past communities and the antiquity of our own society. Special-function vessels used in the transhipment of goods, termed Maritime Transport Cont",{"id":678,"funder":7,"programme":8,"title":679,"piName":10,"institution":680,"country":681,"year":13,"amount":682,"abstract":683},"cordis-european-research-council-award-948063","Ultralow power and ultra-wideband spintronics near thermodynamic limits","KOC UNIVERSITY","TR","€2,500,000","Moores Law drove the technology revolution for more than five decades and left no aspect of our lives untouched. State-of-the-art computation relies on transistors, whose dimensions or power consumption could no longer be reduced. Nevertheless, growing need for information processing, battery-constrained internet-of-things devices and wireless connectivity necessitates discoveries of nanoelectronic building blocks with novel physics. Thus, fundamental breakthroughs are needed in highly power-eff",{"id":685,"funder":7,"programme":8,"title":686,"piName":10,"institution":687,"country":37,"year":13,"amount":38,"abstract":688},"cordis-european-research-council-award-947852","Nanoscale Chemical Imaging of MXene Electrochemical Storage by Operando Scanning X-ray Microscopy","HELMHOLTZ-ZENTRUM BERLIN FUR MATERIALIEN UND ENERGIE GMBH","Finding efficient ways to store and deliver electrical energy is urgently needed for the large-scale development of renewable energy sources. The use of pseudocapacitive materials, such as 2D transition metal carbides and nitrides, so-called MXenes, is an extremely promising solution to achieve electrochemical energy storage with high power and energy densities, benefiting from fast redox reactions on transition metal oxides. Nevertheless, local electrochemical processes occurring at the solid-l",{"id":690,"funder":7,"programme":8,"title":691,"piName":10,"institution":692,"country":54,"year":13,"amount":693,"abstract":694},"cordis-european-research-council-award-950248","The Sensuous Appeal of the Holy. Sensory Agency of Sacred Art and Somatised Spiritual Experiences in Medieval Europe (12th-15th century)","UNIVERSITA DEGLI STUDI DI PADOVA","€1,499,328","Is sight the only sense actively involved in the perception of art? This is a crucial question for Western culture, dominated today by the hegemony of vision and the suppression of the other senses. By challenging the current ocularcentric paradigm, and assimilating notions on the cultural values of sensation, SenSArt provides the first examination of medieval sacred art from the unconventional lens of its sensory agency. Between the 12th and the 15th century Europe underwent an extraordinary ar",{"id":696,"funder":7,"programme":8,"title":697,"piName":10,"institution":698,"country":407,"year":13,"amount":83,"abstract":699},"cordis-european-research-council-award-948220","Effective green financial policies for the low-carbon transition","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","Mitigating dangerous climate change requires a fundamental transition of global economies. This transition calls for an annual investment of 2–4 trillion USD, which is a multiple of current climate investment. Accordingly, the EU and many countries are enacting green financial policies, intervening in the financial sector to improve financing conditions for low-carbon technologies. Examples include green state investment banks, carbon disclosure requirements, and changes to lending regulations. ",{"id":701,"funder":7,"programme":8,"title":702,"piName":10,"institution":703,"country":413,"year":13,"amount":704,"abstract":705},"cordis-european-research-council-award-948819","Bridging Scales in Random Materials","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","€1,142,899","The identification and justification of scaling limits is a central theme in modern PDE theory, reflected for instance in the theories of homogenization and singular limits. In many multiscale PDE models, randomness plays a crucial role: In random media, the quantitative homogenization process is driven by decorrelation and concentration of measure; for ill-posed evolution problems like many interface evolution equations, random noise may provide a regularization, potentially restoring well-pose",{"id":707,"funder":7,"programme":8,"title":708,"piName":10,"institution":519,"country":126,"year":13,"amount":38,"abstract":709},"cordis-european-research-council-award-949378","The Creative Lives of African Universities: Pedagogies of Hope and Despair","AFRIUNI explores cultural representations and lived experiences of university life on the African continent. Building on insights from critical pedagogy and decolonial thought, the project considers in material, affective, and aesthetic terms the forms of structural and epistemic violence, physical discomfort, and individual and collective self-realization that obtain within these contested institutions. The project asks: 1. How are African universities represented in creative work and how do th",{"id":711,"funder":7,"programme":8,"title":712,"piName":10,"institution":713,"country":126,"year":13,"amount":714,"abstract":715},"cordis-european-research-council-award-950212","Advancing Novel imaging Technologies and data analyses in order to understand Interior ocean Carbon Storage","NATIONAL OCEANOGRAPHY CENTRE","€2,197,803","Photosynthesis in the ocean converts approximately 100 Gt of carbon dioxide (CO2) into organic matter every year, of which 5-15% sinks to the deep ocean. The depth to which this organic matter sinks is important in controlling the magnitude of ocean carbon storage, as changes in this flux attenuation depth drive variations in atmospheric pCO2 of up to 200 ppm. Efforts to produce global maps of flux attenuation have yielded starkly contrasting global patterns, blocking our understanding of ocean ",{"id":717,"funder":7,"programme":8,"title":718,"piName":10,"institution":719,"country":353,"year":13,"amount":720,"abstract":721},"cordis-european-research-council-award-949806","Volumetric light-driven bioprinting capturing complex physiological shape, size and function in artificial tissues and organoids","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","€1,870,250","Lab-made artificial tissues and organoids promise to revolutionize medicine, tackling transplant shortage, and to innovate biological and pharmaceutical research, introducing accurate in vitro models of human physiology, as potential alternatives to animal experimentation. The functionality of living organs is intimately linked to their complex architecture, from the physicochemical properties of extracellular microenvironment, to tissue-level scale, where multiple cell populations interact in a",{"id":723,"funder":7,"programme":8,"title":724,"piName":10,"institution":725,"country":54,"year":13,"amount":726,"abstract":727},"cordis-european-research-council-award-948891","Tweaking dreams: non-invasive modulation of the level and content of mental activity during sleep","SCUOLA IMT (ISTITUZIONI, MERCATI, TECNOLOGIE) ALTI STUDI DI LUCCA","€1,488,270","Sleep and wakefulness have traditionally been regarded as two mutually exclusive states characterized by differences in consciousness and responsiveness to the environment. However, the last two decades of research have demonstrated that sleep is actually a locally regulated phenomenon and that cortical islands of sleep- and wake-like activity can often coexist across distinct brain areas. Intriguingly, this mosaic of activity is also directly related to the presence and content of mental activi",{"id":729,"funder":7,"programme":8,"title":730,"piName":10,"institution":731,"country":126,"year":13,"amount":732,"abstract":733},"cordis-european-research-council-award-947778","New Approaches to Counting and Sampling","THE UNIVERSITY OF EDINBURGH","€1,468,303","Probabilistic models have been adopted in almost all scientific disciplines. Many related computational problems arise, involving estimating the probability of certain events, or drawing samples from a desired distribution. These problems, technically known as counting and sampling problems, are the main focus of the NACS project, with an emphasis on rigorous mathematical analysis.Markov chain Monte Carlo algorithms have been designed and applied for counting and sampling long before the computa",{"id":735,"funder":7,"programme":8,"title":736,"piName":10,"institution":625,"country":626,"year":13,"amount":737,"abstract":738},"cordis-european-research-council-award-948497","Books of the Medieval Parish Church","€1,499,808","Book production became a market-orientated craft long before the invention of printing. In the late-medieval manuscript economy, the parish churches formed one of the biggest entities on the demand side. However, at present we know next to nothing about how they were provisioned with books. BOMPAC is a response to this gap in scholarly understanding. It offers the first substantial study of the place of the parish church in the culture and economy of the manuscript book, c. 1150c.1500.   BOMPACs",{"id":740,"funder":7,"programme":8,"title":741,"piName":10,"institution":731,"country":126,"year":13,"amount":742,"abstract":743},"cordis-european-research-council-award-948885","Non-compact Chern-Simons Theory, Positive Representations, and Cluster Varieties","€1,497,425","Over the past 30 years, deep connections between Chern–Simons theory, supersymmetric (SUSY) gauge theory, and representation theory of quantum groups, have caused an avalanche of research in mathematics and physics. In this proposal I use quantum cluster varieties to develop positive representation theory of quantum groups and a non-compact analogue of Chern–Simons theory. I also obtain new invariants of links and 3-manifolds, and establish new connections between SUSY gauge theories and quantum",{"id":745,"funder":7,"programme":8,"title":746,"piName":10,"institution":530,"country":462,"year":13,"amount":747,"abstract":748},"cordis-european-research-council-award-945674","Understanding and targeting  the functional consequences of aneuploidy in cancer","€1,612,500","Aneuploidy, an imbalanced number of chromosomes or chromosome arms, is a distinct feature of cancer. Recent years have seen conceptual, methodological and technical advances in the field of cancer aneuploidy research, but we are just beginning to scratch the surface of the underlying biology, and the potential vulnerabilities of aneuploid cancer cells remain under-explored. Cancer aneuploidy is therefore a biological enigma and a missed opportunity for cancer therapy.Identifying the “Achilles he",{"id":750,"funder":7,"programme":8,"title":751,"piName":10,"institution":514,"country":407,"year":13,"amount":752,"abstract":753},"cordis-european-research-council-award-851961","Improving Market Access for Farmers: Evidence from East Africa","€1,499,913","Agriculture employs the majority of the labor force in many developing countries, particularly in Sub-Saharan Africa. Increasing efficiency of agricultural production is a crucial step to foster economic development. Limited access to both input and output markets is widely considered a major obstacle to technology adoption and, in turn, to agricultural productivity. In this proposal, I outline a research program that focuses on improving farmers market access in East Africa. The research builds",{"id":755,"funder":7,"programme":8,"title":756,"piName":10,"institution":757,"country":105,"year":13,"amount":758,"abstract":759},"cordis-european-research-council-award-948478","Molecular and metabolic mechanisms underlying mitochondrial dysfunction","UNIVERSIDAD AUTONOMA DE MADRID","€1,463,410","Mitochondria are essential organelles that carry out critical metabolic functions within the cells. Electron transport chain (ETC) defects occurring from mitochondrial disease mutations compromise cellular fitness and survival. This biochemical failure is thought to underlie pathologies associated with mitochondrial dysfunction. However, the precise metabolic processes, signaling pathways and compensatory responses resulting from a defective mitochondrial ETC that drive these fatal disorders are",{"id":761,"funder":7,"programme":8,"title":762,"piName":10,"institution":473,"country":383,"year":13,"amount":763,"abstract":764},"cordis-european-research-council-award-948426","Probing MHz processes in 3D with X-ray microscopy","€1,999,213","I aim to develop an X-ray imaging technique capable of filming processes in 3D, with a temporal resolution several orders of magnitude faster than up-to-date 3D X-ray imaging techniques.The unique penetration power of X-rays allows us to study systems in their native environment. This property has led to the development of X-ray microtomography (µCT). µCT acquires 3D information, which determines the functionality and mechanical properties of nature, by rotating a sample with respect to the X-ra",{"id":766,"funder":7,"programme":8,"title":767,"piName":10,"institution":768,"country":126,"year":13,"amount":769,"abstract":770},"cordis-european-research-council-award-948764","Illuminating the darkness with precision maps of neutral hydrogen across cosmic time","THE UNIVERSITY OF MANCHESTER","€1,665,802","My proposal is to map out the 3D structure of the Universe over an unprecedentedly broad swath of cosmic time, covering 13 billion years of cosmic history. I will do this by using radio telescopes to detect the 21cm emission from neutral hydrogen. The detailed statistical properties of the maps will allow us to answer some of the most pressing questions in cosmology, such as how fast space is expanding, what the physical properties of dark energy are, and how the first stars and galaxies lit up ",{"id":772,"funder":7,"programme":8,"title":773,"piName":10,"institution":774,"country":126,"year":13,"amount":775,"abstract":776},"cordis-european-research-council-award-949582","Health Equity and its Economic Determinants (HEED): A Pan-European Microsimulation model for Health impacts of Income and Social Security Policies","UNIVERSITY OF GLASGOW","€1,499,773","Economic determinants, such as income and employment, are key drivers of population health and health inequalities, but have rarely been included in modelling studies to inform policy. This innovative project will develop the Health Equity and its Economic Determinants (HEED) model to investigate the impacts of taxation and social security policies on population health and mortality across Europe. There are 4 phases: 1) creating effect estimates for model inputs, 2) developing the model, 3) tria",{"id":778,"funder":7,"programme":8,"title":779,"piName":10,"institution":508,"country":12,"year":13,"amount":780,"abstract":781},"cordis-european-research-council-award-949963","Morbidity due to Loiasis: population-wide evaluation and identification of pathogenic mechanisms","€1,499,105","Loiasis, an infectious disease caused by the parasitic worm Loa loa, affects more than 15 million individuals in central Africa, and more than 100 million people are potentially exposed to infection. Since its first description in 1770, the international scientific community has considered this filarial disease as benign. I recently demonstrated that loiasis significantly reduces the life expectancy of infected people. I aim to definitively shift the prevailing paradigm of benign loiasis by show",{"id":783,"funder":7,"programme":8,"title":784,"piName":10,"institution":785,"country":37,"year":13,"amount":786,"abstract":787},"cordis-european-research-council-award-949609","How does our brain store bodily experiences?","EBERHARD KARLS UNIVERSITAET TUEBINGEN","€1,496,015","Body memory is the sum of all past bodily experiences that are stored in memory and influence behavior. Body memories influence our daily life, for example when we remember injuries, accidents, or moments of bodily comfort, and they affect mental health, for example when they cause psychosomatic symptoms, depression, or anxiety. Scientific knowledge on the neuroanatomical pathways and neuronal mechanisms that underlie human body memory is scarce, partly because offline representations of bodily ",{"id":789,"funder":7,"programme":8,"title":790,"piName":10,"institution":530,"country":462,"year":13,"amount":791,"abstract":792},"cordis-european-research-council-award-945878","Boosting the discovery using τs in the ATLAS detector at the Large Hadron Collider","€1,420,000","Almost ten years into the highly successful program both in ATLAS and CMS, our understanding of the Standard Model (SM) of particle physics has deepened.  Nonetheless, what lies beyond the SM remains one of the most urgent questions of physics in the 21st  century.   To  move forward, one must  think outside of the box and leap into uncharted waters.  Searches today are aiming at the high-energy frontier, while  low-mass resonances are mostly overlooked by the Large Hadron Collider (LHC). Conseq",{"id":794,"funder":7,"programme":8,"title":795,"piName":10,"institution":796,"country":407,"year":13,"amount":797,"abstract":798},"cordis-european-research-council-award-853378","In vivo gut-brain optogenetic endomicroscopy  for digestive disorders management","WYSS CENTER FOR BIO AND NEURO ENGINEERING","€1,526,438","Proper functioning of the digestive system depends largely on the enteric nervous system (the gut’s brain), which on one side is linked to the gut’s microbiota and on the other side is linked to environmental factors, like stress, via gut-brain axis. Communication along this axis is not very well understood, even though it is crucial for the diagnosis and treatment of functional digestive disorders, which are the most common problems in the digestive system imposing a significant burden on publi",{"id":800,"funder":7,"programme":8,"title":801,"piName":10,"institution":698,"country":407,"year":13,"amount":802,"abstract":803},"cordis-european-research-council-award-949525","Women Writing Architecture: Female Experiences of the Built 1700-1900","€1,454,735","WoWA studies female experiences of architecture as recorded in documentary writing drawn from specific regions in South America and Europe between 1700 and 1900. While architectural histories often focus on male-dominated processes of design and production, this project takes a new stance by unearthing women’s contributions to the architectural sphere through writing and editing. While not part of the canon, articles, travelogues, domestic manuals, or pamphlets authored by women in the period co",{"id":805,"funder":7,"programme":8,"title":806,"piName":10,"institution":807,"country":126,"year":13,"amount":808,"abstract":809},"cordis-european-research-council-award-949367","Becoming Muslim: Cultural Change, Everyday Life and State Formation in early Islamic North Africa (600-1000)","UNIVERSITY COLLEGE LONDON","€1,498,688","The Muslim conquests of North Africa in the 7th century transformed the everyday lives of communities– between 800-1000, the region experienced an economic ‘Golden Age’, visible in the growth of urban populations, intensified exchange across a vast trading system and the introduction of new agricultural practices and technologies. New social-religious norms underpinned the development of a distinctly ‘Islamic cultural package’ marked by the spread of new aesthetics, public and private architectu",{"id":811,"funder":7,"programme":8,"title":812,"piName":10,"institution":376,"country":89,"year":13,"amount":813,"abstract":814},"cordis-european-research-council-award-948473","National institutional autonomy within the EU legal order: uncovering and addressing its distinctive appearances, origins and impact on Member States' administrations","€1,497,687","Despite significant advancements in European integration, the institutional design and organisation of administrative structures implementing and enforcing EU law had traditionally remained the responsibility of EU Member States. Over the past decade, however, EU legislation has increasingly come to impose more organisational requirements on those Member States administrative structures. That evolution is most remarkable as EU law has long recognised the existence of a principle of national inst",{"id":816,"funder":7,"programme":8,"title":817,"piName":10,"institution":818,"country":89,"year":13,"amount":819,"abstract":820},"cordis-european-research-council-award-947654","Inheritance, Demographics, and Economic Development","UNIVERSITE LIBRE DE BRUXELLES","€1,376,916","Economists study inheritance and demographics in isolation, overlooking the feedback effects between the two. This is surprising given that other social scientists have typically related inheritance schemes to family structures. The general objective of this proposal is to understand the implications of these interconnections for the process of economic development. First, I will create new databases for European countries between the seventeenth and the nineteenth centuries and for Sub-Saharan ",{"id":822,"funder":7,"programme":8,"title":823,"piName":10,"institution":824,"country":353,"year":13,"amount":825,"abstract":826},"cordis-european-research-council-award-947717","Quantifying electron-electron forces at the atomic scale","STICHTING RADBOUD UNIVERSITEIT","€1,912,095","Quantum phases of matter in novel 2D materials host fascinating correlated electron properties, such as unconventional superconductivity, novel insulating phases and exotic magnetic order. These phenomena are a hotbed of new forms of energy-efficient technologies, which require fundamental understanding and exploration of these material classes. Since the beginning, scientists have been struggling with the puzzling lack of consistent predictability of such materials, leading predominantly to ser",{"id":828,"funder":7,"programme":8,"title":829,"piName":10,"institution":830,"country":37,"year":13,"amount":38,"abstract":831},"cordis-european-research-council-award-950584","Decoding spatio-temporal omics in progressive neuroinflammation","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","Multiple sclerosis (MS) is a paradigmatic progressive neuroinflammatory disease characterized by multiple lesions across the entire central nervous system including both gray and white matter areas. Deconvoluting the spatio-temporal cellular and molecular landscape is therefore key to understanding underlying disease mechanisms and to develop cell-type specific therapies. The DecOmPress proposal is about integrative human and mouse single-cell genomic strategies to track-down reactive cellular s",{"id":833,"funder":7,"programme":8,"title":834,"piName":10,"institution":371,"country":353,"year":13,"amount":835,"abstract":836},"cordis-european-research-council-award-947317","A multilevel approach to address the role of Archaeal Symbionts in the Evolution of Life","€1,869,946","Microbial symbioses play an essential role in most aspects of lifes evolution and enabled major evolutionary events such as the origin of eukaryotes. But in spite of the importance of symbioses, our knowledge is based on a limited number of microbial host-symbiont systems, few of which include Archaea. Notably, recent cultivation-independent approaches have revealed two hugely diverse microbial groups of putative deep-branching archaeal and bacterial symbionts referred to as DPANN and CPR, respe",{"id":838,"funder":7,"programme":8,"title":839,"piName":10,"institution":840,"country":105,"year":13,"amount":841,"abstract":842},"cordis-european-research-council-award-948557","Sexual Minorities and Inequality of Opportunity","CENTRO DE ESTUDIOS DEMOGRAFICOS","€1,046,000","A voluminous body of research has documented how sexual minorities experience discrimination and stigma in society. At the same time, we know surprisingly little about the extent to which these processes lead to different socioeconomic and family outcomes for sexual minorities. This project will be the first to systematically document cross-national and cross-temporal differences in the socioeconomic and family outcomes of sexual minorities and investigate the conditions under which opportunitie",{"id":844,"funder":7,"programme":8,"title":845,"piName":10,"institution":846,"country":383,"year":13,"amount":847,"abstract":848},"cordis-european-research-council-award-948138","Deciphering the network of microbial, environmental and physical factors underlying aggregation and enhanced performance in syntrophic microorganism communities","SVERIGES LANTBRUKSUNIVERSITET","€992,622","Syntrophic microorganisms perform unique and crucial tasks in microbial processes used for sustainable energy (methane) and nutrient recovery from various organic waste streams. These syntrophic microorganisms cooperate to metabolically degrade acids but there are barriers and challenges to these organisms reaching their full potential, which restricts productivity and stability in the biomethane process. The cooperative lifestyle and cultivation of syntrophic microorganisms strongly points towa",{"id":850,"funder":7,"programme":8,"title":851,"piName":10,"institution":852,"country":37,"year":13,"amount":853,"abstract":854},"cordis-european-research-council-award-949811","Energetics of Biological Systems","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€1,935,240","All living systems function out of thermodynamic equilibrium and require a continuous supply of energy. To understand how cells and organisms function, we need to determine how metabolic energy is partitioned among the complex array of cellular processes that are necessary for life at any scale, from isolated biochemical networks to quiescent and highly proliferative cells to organismal growth and development. To investigate the energetics of living systems, I established calorimetry to measure ",{"id":856,"funder":7,"programme":8,"title":857,"piName":10,"institution":858,"country":450,"year":13,"amount":859,"abstract":860},"cordis-european-research-council-award-950398","Challenging Problems in Infinite-State Systems","UNIWERSYTET WARSZAWSKI","€1,340,406","Investigation of infinite state systems is an active field since the early days of computer science.Despite of decades of research the most fundamental questions are not understood welleven for basic models using only counters or a stack.The aim of the project is to provide solutions of the most challenging problems in the area.The goals of the project are grouped in three tasks: - The first goal in concerned with the reachability problem in Petri nets or Vector Addition Systems (VASes),   a cla",{"id":862,"funder":7,"programme":8,"title":863,"piName":10,"institution":864,"country":413,"year":13,"amount":865,"abstract":866},"cordis-european-research-council-award-947803","Functional Interrogation of Non-coding DNA Sequences in leukemia development and drug resistance","ST. ANNA KINDERKREBSFORSCHUNG GMBH","€1,784,000","Functional non-coding regions of the genome play a fundamental role in gene expression and are enriched for disease associated variants. Perturbation of non-coding regions harbouring disease-associated variants is now the rationale of ongoing clinical trials (e.g. NCT03432364), highlighting the translational potential of basic research in the non-coding space. However, our ability to systematically identify disease-associated functional elements in the non-coding genome, understand its grammar, ",{"id":868,"funder":7,"programme":8,"title":869,"piName":10,"institution":530,"country":462,"year":13,"amount":870,"abstract":871},"cordis-european-research-council-award-851811","Verification-Aware Programming Language Concurrency Semantics","€1,449,528","With the proliferation of multi-core processors, concurrent programming regularly appears at the core of heavily relied-upon systems, where both performance and correctness are of paramount importance. The canonical concurrency model is sequential consistency-identifying concurrent programs with all possible interleavings of operations of their constitute threads. It is a simple model for programmers, but unsatisfactory as a programming language concurrency semantics. First, performance-wise, it",{"id":873,"funder":7,"programme":8,"title":874,"piName":10,"institution":875,"country":25,"year":13,"amount":876,"abstract":877},"cordis-european-research-council-award-946228","Dietary shaping of the early life metabolome and its role in healthy lung and brain development","REGION HOVEDSTADEN","€1,499,952","Asthma and behavioral problems related to neurodevelopmental delay such as ADHD and autism are common childhood disorder with lack of insight in disease mechanisms and no preventive measures, which is an unmet medical and societal need. In the Danish COPSAC mother-child cohort, I showed in two randomized trials that pregnancy supplements with n-3 long-chained polyunsaturated fatty acids (n-3 LCPUFA) and high-dose vitamin D reduced offspring asthma risk, improved cognitive scores and accelerated ",{"id":879,"funder":7,"programme":8,"title":880,"piName":10,"institution":881,"country":353,"year":13,"amount":38,"abstract":882},"cordis-european-research-council-award-948031","Pregnancy and the Human Brain: A Window of Neuroplasticity","STICHTING AMSTERDAM UMC","Pregnancy represents one of the most extreme endocrine events of life, involving unequaled hormone surges that orchestrate widespread maternal adaptations. Animal studies have demonstrated reproduction-related neural and behavioral changes that are evident across the lifespan. However, remarkably little is known on the effects of this monumental transition on the human brain. I have previously shownfor the first timethat pregnancy leads to long-lasting changes in human brain structure, revealing",{"id":884,"funder":7,"programme":8,"title":885,"piName":10,"institution":536,"country":353,"year":13,"amount":886,"abstract":887},"cordis-european-research-council-award-949151","Reintegration Governance","€1,492,177","The Reintegrate project will combine the fields of reintegration and migration governance to establish a new sub-field of reintegration governance (RG). This project will develop a conceptual understanding of what is reintegration governance, its implementation and effectiveness and a new theoretical framework of how different forms of reintegration governance shape returnees reintegration outcomes across an in-depth comparative analysis of four different states: Ethiopia, Morocco, Nepal, and Se",{"id":889,"funder":7,"programme":8,"title":890,"piName":10,"institution":891,"country":54,"year":13,"amount":892,"abstract":893},"cordis-european-research-council-award-950050","Developing tools for the PREDICTion, at individual level, of the CArdiometabolic REsponse to the consumption of dietary (poly)phenols","UNIVERSITA DEGLI STUDI DI PARMA","€2,309,518","The increased burden of cardiometabolic diseases is a major societal challenge worldwide. Plant-based diets, rich in bioactive compounds such as (poly)phenols, may promote cardiometabolic health. However, the preventive effects of these bioactives depend on the individual capacity to produce, and respond to, (poly)phenol metabolites. This heterogeneity in the individual response to the consumption of (poly)phenols is the main hindrance to exploit their potential for the prevention of cardiometab",{"id":895,"funder":7,"programme":8,"title":896,"piName":10,"institution":371,"country":353,"year":13,"amount":897,"abstract":898},"cordis-european-research-council-award-947821","A Reduction Theory for Codes and Lattices in Cryptography","€1,497,888","Codes and lattices are two major mathematical platforms to build quantum-resistant cryptosystems. Theose cryptosystems will soon be standardized and deployed, replacing historical solutions threatened by Shor's quantum algorithm.These new cryptosystems rely on the hardness of finding short vectors in a code or in a lattice, a computational problem called reduction. Our confidence in their security relies on the relentless effort of cryptanalysis: quantifying, elucidating and trying to invalidate",{"id":900,"funder":7,"programme":8,"title":901,"piName":10,"institution":902,"country":383,"year":13,"amount":38,"abstract":903},"cordis-european-research-council-award-948655","A molecular model of the microsporidian infection apparatus","UMEA UNIVERSITET","Microsporidia are opportunistic fungal pathogens that infect organisms as evolutionarily divergent as protists and mammals. Due to their growing impact on the global food supply chain, the environment, and human health, these unusual spore-forming organisms have been classified as emerging pathogens of high priority. Intriguing cell biological features that are central to microsporidian infectivity and pose challenges to drug development are poorly understood due to a lack of structural informat",{"id":905,"funder":7,"programme":8,"title":906,"piName":10,"institution":731,"country":126,"year":13,"amount":907,"abstract":908},"cordis-european-research-council-award-947872","The Epidemiological Revolution","€1,484,115","The Epidemiological Revolution (TER) will trace the historical rise of epidemiological reasoning through the long twentieth century to understand how a novel data science transformed conceptions of health and disease in science and society. The project will map the conditions in which epidemiology became an authoritative science, and reconstruct how the epidemic has assumed scientific and political urgency since 1900. This seismic epistemological shift resulted in new eminence for epidemiologica",{"id":910,"funder":7,"programme":8,"title":911,"piName":10,"institution":912,"country":353,"year":13,"amount":38,"abstract":913},"cordis-european-research-council-award-947761","Aging Brain Matter; a developmental key to addiction risk and resilience","ERASMUS UNIVERSITEIT ROTTERDAM","Despite neuroscientific advances and innovative treatment efforts, for most people addiction remains chronic. Adolescence marks rapid surges in alcohol and cannabis addiction, but also remarkable recovery rates, as most adolescent addictions naturally resolve over time. Brain development holds an import key to understanding the brain’s recovery potential. However, the impact of age on the mechanisms underlying addiction is largely unknown. Capitalizing on adolescents’ unique socio-cognitive sens",{"id":915,"funder":7,"programme":8,"title":916,"piName":10,"institution":917,"country":626,"year":13,"amount":918,"abstract":919},"cordis-european-research-council-award-946012","Coexistence and conflict in the age of complexity: An interdisciplinary study of community dynamics","TAMPEREEN KORKEAKOULUSAATIO SR","€1,814,886","Polarization and inequality amongst citizens are on the rise across Europe. In a context of multiple, and intersecting forms of diversity, peaceful coexistence has been increasingly placed under sustained pressure. Crucially, the urgency of finding sustainable solutions to these developments is constrained by a lack of conceptual and theoretical nuance that inhibits critical thinking about emergent constellations of social and political life. This project explores how affective orientations and ",{"id":921,"funder":7,"programme":8,"title":922,"piName":10,"institution":923,"country":37,"year":13,"amount":924,"abstract":925},"cordis-european-research-council-award-948181","Revolutionizing invasive alien species control using  behavioural economics and animal cognition","FREIE UNIVERSITAET BERLIN","€1,451,805","The aim of COGNITIVE CONTROL is to gain fundamental insights into individual and collective cognition and apply them to the emerging global challenge of invasive animal control. Invasive ants are ecologically devastating, economically damaging, and almost impossible to control. Ants are protected physically and by social immunity. However, their cognitive abilities are almost universally ignored, and offer novel angles of attack. Applying behavioural economic and psychological concepts, I will o",{"id":927,"funder":7,"programme":8,"title":928,"piName":10,"institution":491,"country":89,"year":13,"amount":929,"abstract":930},"cordis-european-research-council-award-948922","Enhancing the performance of 3D-printed organic thermoelectrics by electric field-assisted molecular alignment","€1,710,853","Thermoelectrics (TEs) are important because they can convert heat directly into electrical energy and enable efficient heating\u002Fcooling. However, their popularization has been hindered by 1) their low efficiency (especially at room temperature), 2) the use of rare\u002Ftoxic materials, and 3) the difficulty to process those materials. In 3DALIGN, I target a 3-in-1 solution to these challenges by using for the first time electric-field-assisted molecular alignment of 3D-printed TE polymers. High electr",{"id":932,"funder":7,"programme":8,"title":933,"piName":10,"institution":485,"country":353,"year":13,"amount":934,"abstract":935},"cordis-european-research-council-award-947695","Modeling news flows: How feedback loops influence citizens' beliefs and shape societies","€1,496,671","Our beliefs about society are largely based on information that we encounter through media. This happens more and more in an unbundled form: Single news items are distributed through sharing on social media, sorted by algorithms, and encountered on platforms on which they were not originally published. Many argue that this leads to so-called echo chambers and filter bubbles, communities of people that are only exposed to information they agree with. This is thought to lead to increasing polariza",{"id":937,"funder":7,"programme":8,"title":938,"piName":10,"institution":939,"country":37,"year":13,"amount":940,"abstract":941},"cordis-european-research-council-award-851653","Naked mole-rats to mice: metabolic reprogramming to prevent ischaemic injury","KLINIKUM DER UNIVERSITAET ZU KOELN","€1,550,000","The overarching aim of this proposal is to identify unique features of naked mole-rat cardiac metabolism that serve as advantageous adaptations to deal with a hypoxic environment, a state relevant to heart disease. Coronary heart disease is a leading cause of death and its pathogenesis has been linked to metabolic abnormalities. The naked mole–rat has recently emerged as a rodent model of interest to biomedicine due to its extraordinarily long and healthy lifespan (>36 years). Naked mole-rats ex",{"id":943,"funder":7,"programme":8,"title":944,"piName":10,"institution":785,"country":37,"year":13,"amount":945,"abstract":946},"cordis-european-research-council-award-948753","Bugs as Drugs: Understanding Microbial Interaction Networks to Prevent and Treat Infections","€1,494,437","Our body is inhabited by an enormous number of microbes which are crucial for our health. The bacteria in our gut for example help us to digest food but can also make us sick in case of an infection. The overall composition and function of those communities are strongly shaped by the interactions of the microbes within them e.g. how the microbes influence each others growth. These interactions are especially important in the case of microbial infections. Since pathogens have to interact with the",{"id":948,"funder":7,"programme":8,"title":949,"piName":10,"institution":950,"country":126,"year":13,"amount":951,"abstract":952},"cordis-european-research-council-award-949572","Statistical Host Identification As a Test of Dark Energy","UNIVERSITY OF PORTSMOUTH HIGHER EDUCATION CORPORATION","€1,497,672","The past four years have witnessed dramatic discoveries surrounding the birth of gravitational wave astronomy. By their nature, gravitational waves are ideal probes with which to test the laws of gravity – something currently under scrutiny due to unresolved questions about the dark sector of the universe.  In this proposal I lay out an ambitious campaign to determine the behaviour of gravity over cosmological distances, using the upcoming surge of gravitational wave data. I will achieve this by",{"id":954,"funder":7,"programme":8,"title":955,"piName":10,"institution":807,"country":126,"year":13,"amount":956,"abstract":957},"cordis-european-research-council-award-948561","Depression in diverse populations: Unravelling the interplay between genes and environment","€2,495,950","Depression affects 300 million people and represents one of the biggest challenges to human health to date. Of the burden, 80% pertains to low- and middle-income countries. It is thus imperative to understand the global causes of depression to design effective targeted interventions. DIVERGE will build the first ancestrally diverse data resource for depression, generated from biobanks (N=1.8M) and new studies in Pakistan (N=20K) as well as sub-Saharan Africa (N=13K) with deep phenotyping and gen",{"id":959,"funder":7,"programme":8,"title":960,"piName":10,"institution":961,"country":105,"year":13,"amount":962,"abstract":963},"cordis-european-research-council-award-948677","Identification of age-related Human Blood factors as a therapeutic target for Alzheimer's disease","FUNDACIO BARCELONABETA BRAIN RESEARCH CENTER","€1,498,915","One of the most exciting findings in neuroscience has been the discovery of peripheral blood factors with rejuvenating or ageing effects on the mouse brain. These factors were discovered by parabiosis experiments in which the blood circulation of young and old animals is fused. The findings imply that the properties of young blood can rejuvenate the older brain. Ageing is the most important risk factor for Alzheimer’s Disease (AD), but there have been only limited attempts to develop therapies t",{"id":965,"funder":7,"programme":8,"title":966,"piName":10,"institution":967,"country":968,"year":13,"amount":969,"abstract":970},"cordis-european-research-council-award-850852","Whole genome duplication – the gateway to adaptation?","UNIVERZITA KARLOVA","CZ","€1,993,750","Whole genome duplication (WGD, polyploidization) is arguably the most massive genome-wide mutation whose ubiquity across eukaryotes suggests an adaptive benefit, though no mechanism has been identified. Consequently, a large controversy dominates the field whether WGD represents net benefit or detriment to evolutionary success.I will test if WGD promotes adaptation in natural populations and address the underlying mechanism by estimating net fitness benefit of WGD vs. the role of post-WGD accumu",{"id":972,"funder":7,"programme":8,"title":973,"piName":10,"institution":974,"country":353,"year":13,"amount":38,"abstract":975},"cordis-european-research-council-award-950048","Chromatic homotopy theory of spaces","UNIVERSITEIT UTRECHT","Many current developments in stable homotopy theory are guided by the ‘chromatic perspective’. One decomposes a spectrum into its monochromatic pieces, each of which is a localization corresponding to one of the prime fields of higher algebra (the Morava K-theories, generalizing the prime fields Q and F_p of ordinary algebra). The goal of this proposal is to study the chromatic decomposition of spaces, as opposed to that of spectra. I will establish structural results for the category of all mon",{"id":977,"funder":7,"programme":8,"title":978,"piName":10,"institution":979,"country":407,"year":13,"amount":38,"abstract":980},"cordis-european-research-council-award-948196","Tanycyte\u002Farcuate Neuron communications in the regulation of energy balance","UNIVERSITE DE LAUSANNE","The escalating pandemic of obesity and type-2 diabetes represents one of the most pressing and costly biomedical challenges confronting modern society. The brain's impaired ability to sense and respond to variations in energy homeostasis is increasingly recognized as playing a role in the pathophysiology of these disorders. By sensing the nutritional status of the organism, distinct neural cell populations –including neurons and glia present in the arcuate nucleus of the hypothalamus (ARH)– tigh",{"id":982,"funder":7,"programme":8,"title":983,"piName":10,"institution":984,"country":37,"year":13,"amount":985,"abstract":986},"cordis-european-research-council-award-950349","Understanding collective mechanisms of cell fate regulation using single-cell genomics","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","€1,489,500","Biological systems rely on an influx of energy to build and maintain complex spatio-temporal structures. A striking example of this is the self-organisation of cells into tissues, which relies on an interplay of molecular programs and tissue-level feedback. The mechanistic basis underlying these processes is poorly understood. The recent advent of single-cell sequencing technologies for the first time gives the opportunity to probe these processes with unprecedented molecular resolution in vivo.",{"id":988,"funder":7,"programme":8,"title":989,"piName":10,"institution":990,"country":462,"year":13,"amount":552,"abstract":991},"cordis-european-research-council-award-949707","Coding for Interactive Communication and the Power of Adaptivity","BEN-GURION UNIVERSITY OF THE NEGEV","Error correcting codes allow for reliable transmission of data over unreliable channels. The 70 years of development that went into the study of error correction, following Shannon's ground-breaking paper in 1948, yielded a fairly complete theory with far reaching applications to other theoretical and practical fields. However, many modern communication settings are not simply about transmitting information, but rather operate over many rounds of interactive communication between different parti",{"id":993,"funder":7,"programme":8,"title":994,"piName":10,"institution":807,"country":126,"year":13,"amount":995,"abstract":996},"cordis-european-research-council-award-948548","How our expectations can make us hallucinate: the neural mechanisms underlying perception","€1,484,575","The way we perceive the world is strongly influenced by our expectations about what we are likely to see at any given moment. In certain situations – namely when sensory signals are very weak or noisy and expectations are very strong – expectations can even induce hallucinations: seeing an expected stimulus despite its absence. However, the neural mechanisms by which the brain integrates sensory inputs and expectations, and thereby generates the contents of perception, have yet to be established",{"id":998,"funder":7,"programme":8,"title":999,"piName":10,"institution":1000,"country":37,"year":13,"amount":1001,"abstract":1002},"cordis-european-research-council-award-949021","Selection and Regulation of Compartments  by Fuel-driven Phase Separation","UNIVERSITAET AUGSBURG","€1,498,852","Living cells rely on the compartmentalisation of thousands of different molecules and their chemical reactions. Remarkably, many of such compartments form by phase separation of heteropolymers controlled by sequence-specific interactions and fuel that drives reactions away from equilibrium. If we knew how such polymers with sequence-specific interactions evolve and compartmentalise in fuel-driven multi-component mixtures, we would better understand the role of phase separation in living cells an",{"id":1004,"funder":7,"programme":8,"title":1005,"piName":10,"institution":1006,"country":105,"year":13,"amount":1007,"abstract":1008},"cordis-european-research-council-award-948504","Near-zero-index nanophotonic technologies","UNIVERSIDAD PUBLICA DE NAVARRA","€1,499,625","Near-zero-index (NZI) media is a family of photonic nanostructures (continuous media and\u002For metamaterials) characterized by a near-zero refractive index. As the refractive index approaches zero, spatial and temporal variations of the electromagnetic field decouple, giving rise of a regime of qualitatively different light-matter interactions. Therefore, NZI nanostructures exhibit a unique optical response, where a concept as basic as the geometry plays an essentially different role. Examples of t",{"id":1010,"funder":7,"programme":8,"title":1011,"piName":10,"institution":1012,"country":105,"year":13,"amount":1013,"abstract":1014},"cordis-european-research-council-award-948829","REfining LIgnin by advanced Catalytic schemes powered by Sunlight","UNIVERSIDAD DE ALICANTE","€1,536,183","Turning valuable though outcasted lignocellulosic biomass, such as forestry and agricultural waste, into commodity chemicals by using renewable energies is key to disrupt our ongoing dependence on oil refineries and fossil fuels and to stimulate the growth of a sustainable industry. The lack of effective valorization strategies to mine the valuable chemicals locked into lignin, one of the major components of this biomass, is holding back this transition. Using sunlight to drive this valorization",{"id":1016,"funder":7,"programme":8,"title":1017,"piName":10,"institution":731,"country":126,"year":13,"amount":390,"abstract":1018},"cordis-european-research-council-award-947918","Topologically Active Polymers","Synthetic and biological polymers are everywhere, they make up a wide range of materials, from every-day plastics to living cell. The study of how polymers behave in solution is a well-established research field that allows the informed design of commercial products, from plastics to rocket propellant. Most of the polymers used in everyday applications have a fixed structure that cannot be changed in time and this assumption lies at the heart of classic polymer physics. In this project, I propos",{"id":1020,"funder":7,"programme":8,"title":1021,"piName":10,"institution":382,"country":383,"year":13,"amount":1022,"abstract":1023},"cordis-european-research-council-award-947747","Single-molecule tracking for live-cell protein synthesis kinetics","€1,653,550","This project aims to map the determinants of efficient synthesis, folding, and targeting of proteins in living bacterial cells, and to understand how antibiotic drugs inhibit these events. Our findings will be used to form a quantitative description of how the mRNA sequence ultimately determines how, where, and when a polypeptide should fold, which will help to design better E. coli-based production systems for recombinant proteins; both protein folding and targeting are currently severe bottlen",{"id":1025,"funder":7,"programme":8,"title":1026,"piName":10,"institution":692,"country":54,"year":13,"amount":1027,"abstract":1028},"cordis-european-research-council-award-949087","Bright and biologically powered chemiluminescent labels for cell and tissue imaging","€1,449,750","Imaging is one of the most powerful technique to visualize molecules, tissues, to understand and follow processes and it is the most used diagnostic tool in vitro and in vivo, Current biomedical imaging techniques can have high sensitivity, good spatial\u002Ftemporal resolution and, in some cases, high tissue penetration but cannot combine all of these desired properties without using harmful radiations (or toxic labels) or very expensive equipment. Optical imaging techniques represent the best compr",{"id":1030,"funder":7,"programme":8,"title":1031,"piName":10,"institution":536,"country":353,"year":13,"amount":1032,"abstract":1033},"cordis-european-research-council-award-950189","From School to Career: Towards A Career Perspective on the  Labor Market Returns to Education","€1,499,422","Technological changes and the automation of occupational tasks present societies with a challenge: Is it still sensible to provide students with occupation-specific (vocational) education? Or are students with general educational qualifications better equipped for the future, given that what is demanded in the labor market is under rapid change?While a large literature has shown that graduates with vocational training have a comparatively smooth transition from school to work, it has exclusively",{"id":1035,"funder":7,"programme":8,"title":1036,"piName":10,"institution":1037,"country":126,"year":13,"amount":1038,"abstract":1039},"cordis-european-research-council-award-949506","Post-transcriptional regulation of influenza A virus RNA","THE QUEEN'S UNIVERSITY OF BELFAST","€1,568,010","This research proposal aims to significantly alter our understanding of the critical role post-transcriptional processes play in the influenza A virus (IAV) life cycle. Post-transcriptional regulation of cellular mRNAs has seen a lot of research interest in recent years, including projects looking at the effects of RNA modifications and ribosome specialisation. However, much less attention has been paid to the effects these processes have on the viral life cycle. This project focuses on the post",{"id":1041,"funder":7,"programme":8,"title":1042,"piName":10,"institution":1043,"country":54,"year":13,"amount":1044,"abstract":1045},"cordis-european-research-council-award-948972","Coevolution of Life and Planet: role of trace metal availability in the evolution of biogeochemically relevant redox metalloenzymes","UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II","€2,080,438","Earth’s geosphere and biosphere have coevolved over time, influencing each other’s stability and keeping our planet habitable over the last 4 billion years. Biogeochemical cycles are crucial in this mechanism, connecting long-term geological cycles and the much faster evolution of the Earth’s outer envelopes. A small set of microbial-encoded proteins containing a redox-sensitive transition metal as their core catalytic center carry out the majority of the key biogeochemical reactions. Metals suc",{"id":1047,"funder":7,"programme":8,"title":1048,"piName":10,"institution":1049,"country":968,"year":13,"amount":1050,"abstract":1051},"cordis-european-research-council-award-949191","Optoelectronic medicine - nerve cell regulation with light","VYSOKE UCENI TECHNICKE V BRNE","€1,493,198","Bioelectronic medicine today is growing in leaps and bounds, with ambitious new technologies entering the clinic and already changing the lives of more than a million patients worldwide. Materials scientists are called to craft biomedical devices that are smaller, smarter, and less invasive. We propose to create implantable photovoltaic devices which can wirelessly stimulate the nervous system and enable a new type of minimally invasive optoelectronic medicine. To achieve this, we will use bioco",{"id":1053,"funder":7,"programme":8,"title":1054,"piName":10,"institution":1055,"country":37,"year":13,"amount":1056,"abstract":1057},"cordis-european-research-council-award-947606","Preventing Explosions: How do Powder Flows Electrify?","PHYSIKALISCH-TECHNISCHE BUNDESANSTALT","€1,471,225","The electrification of powder flows is one of the most pervasive phenomena in environmental processes and of tremendous importance for technical applications. In industrial plants, excessive electrostatic charges can even lead to hazardous sparks, which have caused numerous catastrophic dust explosions in the past. However, despite its long history of investigation, it is not currently possible to predict the buildup, transport, and accumulation of charge.Starting from 2015, I developed a numeri",{"id":1059,"funder":7,"programme":8,"title":1060,"piName":10,"institution":1061,"country":37,"year":13,"amount":1062,"abstract":1063},"cordis-european-research-council-award-949465","Information Transmission in Markets","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","€719,596","This proposal studies price negotiations in dynamic markets. The focus is on one of the most primitive economic problems: a seller and a buyer bargain over the price of a good. Their cost and values are private information and, if they do not reach an agreement today, they may continue bargaining tomorrow.Somewhat surprisingly, our knowledge about bargaining with two-sided asymmetric information is still quite limited. Intuitively, on the one hand, signaling forces induce the seller and the buye",{"id":1065,"funder":7,"programme":8,"title":1066,"piName":10,"institution":852,"country":37,"year":13,"amount":1067,"abstract":1068},"cordis-european-research-council-award-948771","Regulatory Logic, Thresholds and Epigenetic Memory:  How cis-regulatory landscapes tune gene activity during mammalian development","€1,494,375","Development of multicellular organisms relies on differential gene activation in a single genome. In response to multiple quantitative signals, cell-type specific transcriptional programs are established that determine cell identify. Their perturbation can result in pathologies such as cancer. Large cis-regulatory landscapes integrate information on cell state, space and time to precisely tune the activity of developmental genes. How cis-regulatory landscapes decode multiple quantitative signals",{"id":1070,"funder":7,"programme":8,"title":1071,"piName":10,"institution":1072,"country":12,"year":13,"amount":1073,"abstract":1074},"cordis-european-research-council-award-947819","Resolving m6A-mediated post-transcriptional control in the human malaria parasite","INSTITUT PASTEUR","€1,499,553","Post-transcriptional regulation in malaria parasites is key to the progression through different developmental stages of the complex life cycle within the human and mosquito host. This includes the asexual proliferation within human red blood cells that is responsible for all clinical symptoms of the disease and the preparation for the environmental changes accompanying transmission from host to vector and vice versa. Although the process that controls the destiny of mRNA are of critical importa",{"id":1076,"funder":7,"programme":8,"title":1077,"piName":10,"institution":276,"country":54,"year":13,"amount":1078,"abstract":1079},"cordis-european-research-council-award-949229","Crystal Engineering the New Generation of Sustainable, Biocompatible and Stimuli Responsive Formulations for the Delivery of Active Ingredients","€1,963,562","CryForm aims at progressing our fundamental knowledge in organic materials crystallization and crystal engineering by: (1) gleaning a mechanistic understanding of the relationship between crystal structure and surface properties; (2) uncovering the thermodynamic and kinetic mechanisms of crystal nucleation and growth at liquid\u002Fliquid and liquid\u002Fgas interfaces; (3) understanding the role of large biomolecules in the modification of crystal growth and nucleation kinetics. This knowledge will enabl",{"id":1081,"funder":7,"programme":8,"title":1082,"piName":10,"institution":536,"country":353,"year":13,"amount":318,"abstract":1083},"cordis-european-research-council-award-949200","Relocating Care within Europe: Moving the elderly to places where care is more affordable","Within care studies, the transnationalization of care has been mainly understood as drawing on (female) migrant care workers and resulting in a ‘care gap’ in the places such workers leave behind. This project looks at the reverse phenomenon: care relocation, in which the ageing body is relocated to places where care is more affordable. This hotly contested trend, described as ‘grandmother deportation’ or ‘geriatric colonialism’, can be seen as an extreme example of the marketization of care, and",{"id":1085,"funder":7,"programme":8,"title":1086,"piName":10,"institution":276,"country":54,"year":13,"amount":290,"abstract":1087},"cordis-european-research-council-award-948769","Solar driven electrochemical nitrogen fixation for ammonia refinery","The preservation of our planet is the most urgent issue in the world, and the COP21 conference pushed a lot of researchers to work on technologies for the storage\u002Fconversion of CO2 into chemicals. However, since I believe that it is easier not to produce CO2 than setting-up plants to treat it, I propose an alternative breakthrough based on a versatile solar-driven strategy leading to redesign industrial processes. Facing the Haber-Bosch process for ammonia production (one of the most impactful c",{"id":1089,"funder":7,"programme":8,"title":1090,"piName":10,"institution":1091,"country":25,"year":13,"amount":1092,"abstract":1093},"cordis-european-research-council-award-949830","Toxin mimetics of human peptides as novel tools for drug discovery and design","KOBENHAVNS UNIVERSITET","€1,498,598","Venomous animals use a myriad of toxins to specifically disrupt the physiology and behavior of their prey. Because of their high stability, potency, and specificity, toxins are important tools for biomedical research and have been developed as therapeutics for various human diseases. However, contributions to date pale in comparison to future prospects. We hypothesize that a small and essentially overlooked group of toxins, “ToxMims”, represent the most promising candidates for drug discovery an",{"id":1095,"funder":7,"programme":8,"title":1096,"piName":10,"institution":590,"country":37,"year":13,"amount":1097,"abstract":1098},"cordis-european-research-council-award-948088","Understanding Cerebral Malaria using 3D Blood-Brain Barrier models","€1,492,900","Malaria is a major public health problem and it still causes more than 400,000 deaths per year. Cerebral malaria (CM) is one of the most serious complications, with 20% mortality rates even after administration of fast-acting antimalarials. CM pathology is characterized by sequestration of P. falciparum-infected red blood cells (iRBC) in the brain microvasculature, blood-brain barrier (BBB) disruption, and brain swelling. Our current knowledge of CM is primarly based on autopsy studies, because ",{"id":1100,"funder":7,"programme":8,"title":1101,"piName":10,"institution":1102,"country":105,"year":13,"amount":1103,"abstract":1104},"cordis-european-research-council-award-948432","Information, Markets, and the Macroeconomy","Centre de Recerca en Economia Internacional (CREI)","€767,500","Financial markets play an essential role in allocating an economy’s resources to their most productive use, fostering investment, employment, innovation, and growth. While there is substantial evidence that financial markets are plagued with information asymmetries and its perils, we do not have a good understanding of what economic conditions may foster such information asymmetries, or how they interact with aggregate investment decisions, liquidity in asset markets, or economic fluctuations. I",{"id":1106,"funder":7,"programme":8,"title":1107,"piName":10,"institution":1091,"country":25,"year":13,"amount":1108,"abstract":1109},"cordis-european-research-council-award-949043","Nano-mechanical quantum photonic circuits","€1,485,362","Photons are essential for transmitting quantum information and for building entangled system on a global scale. Recent developments in photonic quantum technologies provide the fundamental tools for generating and manipulating photons within a chip. Yet, performing large-scale experiments, involving many quantum bits (or qubits), remains a major challenge due to the lack of a method to incorporate and control many sources of identical photons in the same chip. With an efficient strategy to contr",{"id":1111,"funder":7,"programme":8,"title":1112,"piName":10,"institution":1113,"country":37,"year":13,"amount":1114,"abstract":1115},"cordis-european-research-council-award-948748","The developmental origins of corruption: A cooperative perspective","UNIVERSITAET LEIPZIG","€1,498,442","Cooperation is at the core of humanitys greatest achievements but its negative consequences have hardly been considered. Specifically, everyday corruption, while being immensely harmful to the collective, is often distinctly cooperative from the perspective of its participants (e.g., exchanging bribes, insider trading). What are the psychological origins of such corrupt behaviors and can they be traced back to fundamental aspects of human psychology? In the past, developmental psychology has bee",{"id":1117,"funder":7,"programme":8,"title":1118,"piName":10,"institution":1119,"country":407,"year":13,"amount":1120,"abstract":1121},"cordis-european-research-council-award-949852","Is environmental justice necessary for human well-being? Comparative analysis of certification schemes, inclusive business, and solidarity economy strategies","UNIVERSITAET BERN","€1,499,250","Unprecedented concentration in agri-food value chains is reinforcing global inequality. Waves of land grabbing threaten the livelihoods of millions. Reshaping the effects of agricultural investment, land use, and trade on human well-being is thus an urgent challenge. Certification schemes (CS) such as Fairtrade have become a common strategy to meet this challenge. However, accumulating evidence shows that many CS have limited effects on well-being. Inclusive business (IB) and solidarity economy ",200,{"programme":8,"total":1124,"withPiName":1125,"firstYear":1126,"lastYear":1127,"countryCount":1128,"perYear":1129,"topInstitutions":1187,"topCountries":1257},7919,572,2008,2027,52,[1130,1132,1135,1138,1141,1144,1147,1150,1153,1156,1159,1162,1165,1168,1170,1173,1176,1179,1182,1185],{"year":1126,"count":1131},279,{"year":1133,"count":1134},2009,157,{"year":1136,"count":1137},2010,302,{"year":1139,"count":1140},2011,447,{"year":1142,"count":1143},2012,524,{"year":1145,"count":1146},2013,456,{"year":1148,"count":1149},2014,297,{"year":1151,"count":1152},2015,366,{"year":1154,"count":1155},2016,376,{"year":1157,"count":1158},2017,419,{"year":1160,"count":1161},2018,582,{"year":1163,"count":1164},2019,393,{"year":1166,"count":1167},2020,384,{"year":13,"count":1169},394,{"year":1171,"count":1172},2022,514,{"year":1174,"count":1175},2023,512,{"year":1177,"count":1178},2024,473,{"year":1180,"count":1181},2025,482,{"year":1183,"count":1184},2026,556,{"year":1127,"count":1186},6,[1188,1190,1193,1196,1198,1201,1204,1207,1210,1213,1216,1218,1221,1224,1227,1230,1233,1236,1238,1240,1243,1245,1248,1251,1254],{"name":1189,"count":1169},"Centre National de la Recherche Scientifique CNRS",{"name":1191,"count":1192},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",175,{"name":1194,"count":1195},"University of Cambridge",129,{"name":1197,"count":1195},"University of Oxford",{"name":1199,"count":1200},"Hebrew University of Jerusalem",112,{"name":1202,"count":1203},"University College London",110,{"name":1205,"count":1206},"Tel Aviv University",107,{"name":1208,"count":1209},"Weizmann Institute of Science",104,{"name":1211,"count":1212},"Eidgenoessische Technische Hochschule Zuerich",87,{"name":1214,"count":1215},"Kobenhavns Universitet",85,{"name":1217,"count":1215},"Universiteit Gent",{"name":1219,"count":1220},"Universiteit van Amsterdam",84,{"name":1222,"count":1223},"École Polytechnique Fédérale de Lausanne",83,{"name":1225,"count":1226},"Ludwig-Maximilians-Universitaet Muenchen",82,{"name":1228,"count":1229},"Institut National de la Sante Et de la Recherche Medicale",78,{"name":1231,"count":1232},"Universiteit Utrecht",76,{"name":1234,"count":1235},"Imperial College of Science Technology and Medicine",71,{"name":1237,"count":1235},"Katholieke Universiteit Leuven",{"name":1239,"count":1235},"Technische Universiteit Delft",{"name":1241,"count":1242},"Technion - Israel Institute of Technology",70,{"name":1244,"count":1242},"Technische Universitaet Muenchen",{"name":1246,"count":1247},"Universiteit Leiden",69,{"name":1249,"count":1250},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",67,{"name":1252,"count":1253},"The University of Edinburgh",64,{"name":1255,"count":1256},"Helsingin Yliopisto",57,[1258,1260,1262,1264,1266,1267,1269,1271,1273,1275,1277,1279,1281,1283,1284,1286,1289,1292,1294,1296,1298,1301,1304,1306,1309],{"name":37,"count":1259},1346,{"name":126,"count":1261},1007,{"name":12,"count":1263},932,{"name":353,"count":1265},772,{"name":54,"count":1175},{"name":105,"count":1268},475,{"name":462,"count":1270},470,{"name":407,"count":1272},389,{"name":89,"count":1274},348,{"name":383,"count":1276},291,{"name":413,"count":1278},269,{"name":25,"count":1280},189,{"name":626,"count":1282},137,{"name":346,"count":1203},{"name":324,"count":1285},108,{"name":1287,"count":1288},"PT",92,{"name":1290,"count":1291},"GB",68,{"name":450,"count":1293},60,{"name":968,"count":1295},43,{"name":503,"count":1297},41,{"name":1299,"count":1300},"US",36,{"name":1302,"count":1303},"HU",32,{"name":681,"count":1305},24,{"name":1307,"count":1308},"SI",14,{"name":1310,"count":1311},"EE",10]