[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-starting-grant-2023":3,"awarded-stats-erc-starting-grant":1093},{"awarded":4,"total":1092},[5,16,22,29,36,42,47,53,60,66,72,79,85,91,96,103,109,115,121,128,134,139,145,151,158,165,172,178,184,190,196,201,207,214,220,226,232,236,241,247,253,259,265,270,276,282,288,292,297,303,309,315,320,325,331,335,341,346,351,357,363,368,373,380,386,392,398,402,407,413,419,425,430,434,440,445,450,457,463,469,475,480,486,491,496,501,506,512,518,523,528,533,539,545,550,555,561,567,571,575,580,586,591,596,602,606,612,617,622,627,633,638,642,647,652,657,661,667,671,675,680,686,692,696,702,707,712,719,724,729,735,740,746,751,757,763,769,775,781,787,793,798,804,809,814,818,823,828,832,837,842,848,854,860,865,870,875,880,885,890,896,902,908,913,918,923,927,933,937,943,948,952,957,962,967,973,977,981,987,993,997,1002,1008,1013,1017,1022,1027,1031,1035,1039,1043,1048,1052,1057,1062,1066,1072,1077,1083,1088],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-101041491","European Research Council","ERC Starting Grant","Correspondences in enumerative geometry: Hilbert schemes, K3 surfaces and modular forms",null,"RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","DE",2023,"€1,429,135","Enumerative geometry is concerned with counting geometric objects on spaces defined by polynomial equations. The subject, which has roots going back to the ancient Greeks, was revolutionized by string theory in the 90s and has since become a fundamental link between algebraic geometry, representation theory, number theory and physics. With K3Mod I propose to establish a wide range of new correspondences in enumerative geometry. These link together different enumerative theories and open new pers",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":12,"year":13,"amount":20,"abstract":21},"cordis-european-research-council-award-101041975","Vibrational Micro-robots in Viscoelastic Biological Tissues","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","€1,499,728","Wireless micro-robots hold great potential for minimally-invasive medicine, since they may allow for targeted drug delivery, in vivo sensing, stimulation, and even new surgical procedures. However, the biggest hurdle for biomedical applications is the penetration of real biological media, for instance, mucus, vitreous, blood clots and tumour tissues. Most current micro-\u002Fnano-robots can propel in water, however, the same propulsion mechanisms do not readily transfer to viscoelastic biological med",{"id":23,"funder":7,"programme":8,"title":24,"piName":10,"institution":25,"country":26,"year":13,"amount":27,"abstract":28},"cordis-european-research-council-award-101043189","Omni-Supervised Learning for Dynamic Scene Understanding","NVIDIA ITALY S.R.L.","IT","€1,500,000","Computer vision has become a powerful technology, able to bring applications such as autonomous vehicles and social robots closer to reality. In order for autonomous vehicles to safely navigate a scene, they need to understand the dynamic objects around it. In other words, we need computer vision algorithms to perform dynamic scene understanding (DSU), i.e., detection, segmentation, and tracking of multiple moving objects in a scene. This is an essential feature for higher-level tasks such as ac",{"id":30,"funder":7,"programme":8,"title":31,"piName":10,"institution":32,"country":33,"year":13,"amount":34,"abstract":35},"cordis-european-research-council-award-101039522","Quantum Information Processing in High-Dimensional Ion Trap Systems","UNIVERSITAET INNSBRUCK","AT","€1,499,790","Quantum processors have taken the binary paradigm of classical computing to the quantum realm and are starting to outperform the best classical devices. Yet, neither the underlying quantum information carriers, nor many of the targeted problems naturally fit into this two-level paradigm. In this project, I aim to break this paradigm. Instead of restricting the rich Hilbert space of trapped ions to only two levels, the proposed research will make full use of the multi-level (qudit) structure as a",{"id":37,"funder":7,"programme":8,"title":38,"piName":10,"institution":39,"country":40,"year":13,"amount":27,"abstract":41},"cordis-european-research-council-award-101040534","COgnitive Dynamics in Early Childhood","STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM","NL","Cognitive ability, measured through standardized tests, provides a highly predictive measure of lifespan outcomes including academic achievement, job success, as well as mental and physical health. However, these cognitive snapshots omit a crucial aspect of cognitive ability: Short term variability in cognitive performance. Individuals with more variable performance are more likely to be mis-stratified into schools or careers with potential lifelong consequences, and more likely to perform at le",{"id":43,"funder":7,"programme":8,"title":44,"piName":10,"institution":45,"country":12,"year":13,"amount":27,"abstract":46},"cordis-european-research-council-award-101039827","Higher-Order Hodge Laplacians for Processing of multi-way Signals","RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN","Network analysis has revolutionized our understanding of complex systems, and graph-based methods have emerged as powerful tools to process signals on non-Euclidean domains via graph signal processing and graph neural networks. The graph Laplacian and related matrices are pivotal to such analyses: i) the Laplacian serves as algebraic descriptor of the relationships between nodes; moreover, it is key for the analysis of network structure, for local operations such as averaging over connected node",{"id":48,"funder":7,"programme":8,"title":49,"piName":10,"institution":50,"country":12,"year":13,"amount":51,"abstract":52},"cordis-european-research-council-award-101040177","Society-Aware Machine Learning: The paradigm shift demanded by society to trust machine learning.","UNIVERSITAT DES SAARLANDES","€1,499,845","To date, the design of ethical machine learning (ML) algorithms has been dominated by technology owners and remains broadly criticized for strategically seeking to avoid legally enforceable restrictions. In order to foster trust in ML technologies, society demands technology designers to deeply engage all relevant stakeholders in the ML development. This ERC project aims at responding to this call with a society-aware approach to ML (SAML). My goal is to enable the collaborative design of ML alg",{"id":54,"funder":7,"programme":8,"title":55,"piName":10,"institution":56,"country":57,"year":13,"amount":58,"abstract":59},"cordis-european-research-council-award-101040999","Acting Out Disease. How Patient Organizations Shaped Modern Medicine","UPPSALA UNIVERSITET","SE","€1,499,773","This project will provide crucial insights into the development of modern medicine and the role of lay involvement in science through analysis of so far largely neglected, but central actors in 20th century medical history: patient organizations. These groups first emerged in the late 19th century, and worked towards increased attention to particular illnesses, shared information on disease management, promoted treatments, and developed healthcare resources. This project is the first historical ",{"id":61,"funder":7,"programme":8,"title":62,"piName":10,"institution":63,"country":12,"year":13,"amount":64,"abstract":65},"cordis-european-research-council-award-101040163","The Logistics of Popular Uprisings","FREIE UNIVERSITAET BERLIN","€1,499,605","Imagine you protest the slide of your country into an autocratic regime. The weather is freezing and you rally in these conditions for weeks. Not a pleasant idea, yet in 2004 thousands of Ukrainians demonstrated against electoral fraud and established a permanent protest camp in Kyiv. For two months, thousands of protesters were in this urban camp, requiring food, toilet facilities and accommodations to regain warmth. And not only in Ukraine, but all over the world, people protest under difficul",{"id":67,"funder":7,"programme":8,"title":68,"piName":10,"institution":69,"country":40,"year":13,"amount":70,"abstract":71},"cordis-european-research-council-award-101039782","The Electrophysiological Landscape of Dreams","KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW","€1,748,906","Why and how do we dream? Although this question has fascinated humankind since the earliest ages, it remains largely unanswered. Each night, when we fall asleep, we progressively disengage from the external world until we cease to perceive it and to act upon it. Despite this sensorimotor disconnection, in our dreams we perceive and act, and although we do so in a purely imaginary world, our experiences bear so much resemblance with the real world that we almost invariably take them for real. How",{"id":73,"funder":7,"programme":8,"title":74,"piName":10,"institution":75,"country":76,"year":13,"amount":77,"abstract":78},"cordis-european-research-council-award-101041759","Reversible Heterolytic Mechanophores for Dynamic Bulk Materials","FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA","ES","€1,498,401","Stimuli-responsive polymers adapt their properties in response to external cues. Engineering such “smart” behaviour in artificial systems by molecular design is an exciting fundamental challenge that can lead to technological breakthroughs. Most stimuli-responsive polymers rely on heat and light to trigger changes in materials properties in a predictable fashion. However, limitations intrinsic to these stimuli highlight the necessity of alternative strategies. Naturally evolved systems widely ex",{"id":80,"funder":7,"programme":8,"title":81,"piName":10,"institution":82,"country":12,"year":13,"amount":83,"abstract":84},"cordis-european-research-council-award-101039098","Enhanced quantum resilience through twists","UNIVERSITY OF HAMBURG","€1,458,688","Quantum technology will revolutionize information transmission, processing, and sensing with unprecedented potential for science, economy, and the society as a whole. Yet, the strong sensitivity of quantum systems to unavoidable environmental noise impedes quantum technological breakthroughs. Here, we propose to twist coupled elemental quantum systems such that they form a global, robust quantum state that is resilient against environmental perturbations. For instance, in magnetic spin chains, f",{"id":86,"funder":7,"programme":8,"title":87,"piName":10,"institution":88,"country":89,"year":13,"amount":27,"abstract":90},"cordis-european-research-council-award-101039378","Fundamentals of formal properties of nonmanuals: A quantitative approach","UNIVERSITETET I BERGEN","NO","Sign languages, in addition to using the hands, also use positions and movements of other articulators: the body, the head, the mouth, the eyebrows, the eyes and the eyelids, to convey lexical, grammatical, and prosodic information. This linguistic use of the nonmanual articulators is known as nonmanuals. Contrary to current assumptions in the field of sign linguistics, this project proposes the hypothesis that all sign languages use the same basic universal building blocks (nonmanual movements)",{"id":92,"funder":7,"programme":8,"title":93,"piName":10,"institution":94,"country":12,"year":13,"amount":27,"abstract":95},"cordis-european-research-council-award-101040939","Spatial-Temporal Dynamics of Flood Resilience","LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN","Existing studies on flood-society relations overwhelmingly concentrate on risk, exposure, vulnerability, damage, loss, and adaptation needs, most of which adopt a negative perspective. The fact that various human societies have well survived and continuously developed in flood prone areas (e.g., coasts, river deltas, flood plains, hilly valleys) is far less studied. Closing this research gap requires a deeper historical perspective to investigate the resilience of human society to floods, i.e., ",{"id":97,"funder":7,"programme":8,"title":98,"piName":10,"institution":99,"country":100,"year":13,"amount":101,"abstract":102},"cordis-european-research-council-award-101042781","Design Rules for Efficient Photogeneration in Metal Oxides","BEN-GURION UNIVERSITY OF THE NEGEV","IL","€2,000,000","Photoelectrochemical (PEC) water splitting is an attractive route for green hydrogen production. Despite nearly half a century of research efforts, no material has successfully met the stringent requirements for a photoelectrode material, the light harvesting semiconductor within the PEC cell. Metal-oxides are widely viewed as the most promising photoelectrode materials for their exceptional stability in aqueous electrolytes, but those with suitable band gaps for visible light absorption typical",{"id":104,"funder":7,"programme":8,"title":105,"piName":10,"institution":106,"country":76,"year":13,"amount":107,"abstract":108},"cordis-european-research-council-award-101039429","IMAGINE climate change adaptation in urban areas","ASOCIACION BC3 BASQUE CENTRE FOR CLIMATE CHANGE - KLIMA ALDAKETA IKERGAI","€1,499,775","Impacts of climate change are happening as a result of extreme temperatures, sea-level rise, storm surges or droughts. Communities and governments across the globe are preparing through actions to increase climate resilience. However, progress made to date to adapt is still poorly understood and tracked due to a lack of theoretical understanding and means to evaluate how well the world is adapting. Further barriers are unclear goals and metrics for adaptation in the absence of a shared definitio",{"id":110,"funder":7,"programme":8,"title":111,"piName":10,"institution":112,"country":26,"year":13,"amount":113,"abstract":114},"cordis-european-research-council-award-101042655","Scribes of Musical Cultures. Decoding Early Technologies of Music Writing  in Latin Europe c. 900–1100","UNIVERSITA DEGLI STUDI DI PAVIA","€1,497,793","From Bach to Beethoven, Verdi to The Beatles, whether elite or popular genres, our collective musical culture was shaped by complex technologies of music writing first invented c.1200 years ago in western Europe. SCRIBEMUS will elucidate the first spreading of musical notation in Latin Europe, one of the most debated topics in historical musicology since the 19th c. The project will address significant lacunae in our understanding of how music scripts were shaped and exchanged within transregion",{"id":116,"funder":7,"programme":8,"title":117,"piName":10,"institution":118,"country":40,"year":13,"amount":119,"abstract":120},"cordis-european-research-council-award-101043014","The biofabrication of a 3D in vitro human oviduct model to study infertility and factors affecting embryo development","UNIVERSITEIT MAASTRICHT","€2,318,530","Despite being viewed as a simple transport conduit, the oviduct can determine a successful pregnancy and has a life-long impact on our health and wellbeing. Also called the fallopian tube, our understanding of tubal function remains limited, owing to the ethical limitations of human studies and the poor translations of animal studies to people. The objective of the OviChip project is to create the first full-scale 3D in vitro model of the oviduct that can address our knowledge gap. The oviduct s",{"id":122,"funder":7,"programme":8,"title":123,"piName":10,"institution":124,"country":125,"year":13,"amount":126,"abstract":127},"cordis-european-research-council-award-101042460","Interplay of structures in conformal and universal random geometry","AALTO KORKEAKOULUSAATIO SR","FI","€1,389,728","My overall goal is to provide novel conceptual understanding of persistent challenges in mathematical physics, in light of recent discoveries of myself and others. The emphasis is especially in finding connections between different areas, making use of my expertise at their crossroads. The first two aims concern statistical mechanics (SM) and mathematical formulations of (logarithmic) conformal field theory (CFT), on the one hand algebraically and on the other hand probabilistically. The last tw",{"id":129,"funder":7,"programme":8,"title":130,"piName":10,"institution":131,"country":12,"year":13,"amount":132,"abstract":133},"cordis-european-research-council-award-101043071","Model Transfer and its Challenges in Science:  The Case of Economics","GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER","€1,499,476","How can a single model be used to study predator-prey interactions in biology, the growth of cancer in medicine, and the business cycle in economics? And how is this practice supposed to contribute to progress in science? To answer those questions, we need to understand how models are transferred across domains. While model transfer is one of the most pertinent phenomena in modern science, philosophers have not yet given it due attention. Our project will fill this lacuna in a ground-breaking wa",{"id":135,"funder":7,"programme":8,"title":136,"piName":10,"institution":112,"country":26,"year":13,"amount":137,"abstract":138},"cordis-european-research-council-award-101039467","COmputational DEsign for 4D BIOfabrication: harnessing programmable materials for dynamic pre-clinical cancer models","€1,495,100","Cancer is a global health burden. In-vitro pre-clinical models play a key role in fighting this burden by encompassing all the activities prior to clinical trials, from tumor microenvironment reconstruction to drug candidate selection. However, the frequent failure of promising pre-clinical drug candidates highlights two major drawbacks of these models: (i) the difficult reproduction of the dynamic cancer structure related to numerous physical cues; (ii) their experimental nature that suffers fr",{"id":140,"funder":7,"programme":8,"title":141,"piName":10,"institution":142,"country":57,"year":13,"amount":143,"abstract":144},"cordis-european-research-council-award-101042529","Mechanisms of Social Learning in Social Contagion and Cultural Evolution","KAROLINSKA INSTITUTET","€1,499,993","Social learning – learning from the behaviors of others – is key for our success as a species. Ideas and behaviors are transmitted between individuals and across generations via social learning, which gives rise to the evolution of human cultures. Social learning might also fuel modern threats, such as the growing social contagion of misinformation in social networks. Despite the crucial role of social learning across a myriad of human behaviors, surprisingly little is known about the (i) psycho",{"id":146,"funder":7,"programme":8,"title":147,"piName":10,"institution":148,"country":26,"year":13,"amount":149,"abstract":150},"cordis-european-research-council-award-101040197","Controlling spin properties of molecules with quantum fields: ab-initio methodologies for spin polaritons","UNIVERSITA DEGLI STUDI DI PERUGIA","€1,499,754","The goal of QED-Spin is to build novel ab initio techniques to reveal effects induced by quantum fields on the spin properties of molecules.  Quantum computing and spectroscopic techniques are just two of the main fields that stand to benefit significantly from advancements in spin engineering; a field that is currently at the science frontier both for  experiments and quantum many body theory. In this project I will propose new strategies based on strong light-matter coupling to manipulate stat",{"id":152,"funder":7,"programme":8,"title":153,"piName":10,"institution":154,"country":155,"year":13,"amount":156,"abstract":157},"cordis-european-research-council-award-101039270","A new ERA for Environmental Risk Assessment: Chirality as a tool towards environmentally safe pharmaceuticals","UNIVERSIDADE DO PORTO","PT","€1,499,950","The detrimental effects on ecosystems and human health caused by the emerging contamination of aquatic environment by pharmaceuticals urges a disruptive prevention strategy. These drugs, their metabolites and transformation products (TPs) are stable, poorly biodegraded, and recalcitrant. Though novel mitigation measures have been proposed, they are insufficient and often risky due to the possible generation of TPs. Under this increasingly deteriorating scenario for future generations, ERA|ARE as",{"id":159,"funder":7,"programme":8,"title":160,"piName":10,"institution":161,"country":162,"year":13,"amount":163,"abstract":164},"cordis-european-research-council-award-101039066","Climate change impacts on trees reproduction and forecasts of forest recruitment change","UNIWERSYTET IM. ADAMA MICKIEWICZA WPOZNANIU","PL","€1,482,050","The capacity of future forests to support biodiversity and deliver ecosystem services will depend on reproductive capacities that keep pace with 21st century climate change. The European continent is warming and drying out fast, and similar changes are happening word wide. The decade-scale trends in biodiversity will be governed by tree fecundity?the capacity of trees to produce seed and to disperse it to the habitats where populations can survive in the future. From the boreal to the tropical f",{"id":166,"funder":7,"programme":8,"title":167,"piName":10,"institution":168,"country":169,"year":13,"amount":170,"abstract":171},"cordis-european-research-council-award-101116486","ENabling Self-Driving in Uncertain Real Environments","KOC UNIVERSITY","TR","€1,497,920","ENSURE addresses the challenge of self-driving in uncertain situations of the real world. Due to the difficulty of reasoning in complex real-world scenarios, self-driving remains one of the most difficult research problems today. For safe navigation, the driving agent needs to be able to anticipate the consequences of its actions. Current solutions are reactive without any planning for what might happen in the future. This poses major safety issues and delays the deployment of self-driving vehic",{"id":173,"funder":7,"programme":8,"title":174,"piName":10,"institution":175,"country":33,"year":13,"amount":176,"abstract":177},"cordis-european-research-council-award-101039843","The sympatric lifestyle of giant viruses: contact tracing and fitness through mobile genetic elements","UNIVERSITAT WIEN","€1,499,899","Giant viruses appear to be ubiquitous in soil and aquatic environments, infecting a wide range of protist hosts. As lytic viruses, they are important regulators in nutrient and energy cycles and key influencers of microbial community composition. The recent discovery of giant viruses challenged previous assumptions and blurred the sharp division between viruses and cellular life. Besides large particle sizes, giant viruses possess complex chimeric genomes, including genes that were likely acquir",{"id":179,"funder":7,"programme":8,"title":180,"piName":10,"institution":181,"country":12,"year":13,"amount":182,"abstract":183},"cordis-european-research-council-award-101040811","Distorting unconventional superconductivity - A grasp of electronic phases with multiple broken symmetries","RUHR-UNIVERSITAET BOCHUM","€1,499,536","When electrons in a solid interact strongly, they can form novel states of matter with fascinating technological possibilities and intriguing intellectual challenges. They might realize the macroscopic quantum state with dissipationless transport – superconductivity – or spontaneously lose spherical symmetry – an electronic nematic state. Surprisingly, more and more nematic superconductors, combining both, have recently been discovered. Such observations suggest a fundamental link between nemati",{"id":185,"funder":7,"programme":8,"title":186,"piName":10,"institution":187,"country":76,"year":13,"amount":188,"abstract":189},"cordis-european-research-council-award-101041741","Leveraging Early Adolescence for Development: Longitudinal and Experimental Evidence from Ghana","UNIVERSITAT DE BARCELONA","€1,638,020","Early adolescence is a key window for human development. Strategic timing of interventions during this life stage may seize opportunities and prevent risks; bolster the impact of earlier investments; and ease damages from previous adversity. Yet evidence on whether such programs can fulfil this potential, for which children, and through which channels, is scant, especially in low-resource settings, where 90% of the world’s 1.2 billion adolescents live. I will tackle these gaps by relying on a co",{"id":191,"funder":7,"programme":8,"title":192,"piName":10,"institution":193,"country":12,"year":13,"amount":194,"abstract":195},"cordis-european-research-council-award-101116395","Cascade Processes for Sparse Machine Learning","CISPA - HELMHOLTZ-ZENTRUM FUR INFORMATIONSSICHERHEIT GGMBH","€1,499,285","Deep learning continues to achieve impressive breakthroughs across disciplines and is a major driving force behind a multitude of industry innovations. Most of its successes are achieved by increasingly large neural networks that are trained on massive data sets. Their development inflicts costs that are only affordable by a few labs and prevent global participation in the creation of related technologies. The huge model sizes also pose computational challenges for algorithms that aim to address",{"id":197,"funder":7,"programme":8,"title":198,"piName":10,"institution":199,"country":40,"year":13,"amount":27,"abstract":200},"cordis-european-research-council-award-101116116","Materials-GRoWL: Gauging the Rest-of-World’s Lifecycles of construction materials","UNIVERSITEIT LEIDEN","This project, Materials-GRoWL, will assess the current and future construction material uses that compose human settlements of the Global South, which is sometimes indiscreetly aggregated as the Rest of the World (RoW) in global studies. This is crucial, because construction materials have global environmental impacts: half of yearly consumption of all raw materials, significant shares of carbon emissions, and major contributors to land use change. Most of their future demands and thus environme",{"id":202,"funder":7,"programme":8,"title":203,"piName":10,"institution":204,"country":100,"year":13,"amount":205,"abstract":206},"cordis-european-research-council-award-101117324","Using super-resolved in situ sequencing to reveal the cellular encoding of immune-tumour contact events","BAR ILAN UNIVERSITY","€2,124,896","Despite the constant surveillance of immune cells, tumour cells can still evade the immune response. Unravelling the interactions of T cells and B cells with tumour cells can shed light on tumour evasion. Extensive research is focused on the mechanisms of activation of an immune response in T cells. However, it is known that detection events, i.e., physical contact between individual surveying T cells and tumour cells, don’t necessarily lead to such activation. Little is known about physical int",{"id":208,"funder":7,"programme":8,"title":209,"piName":10,"institution":210,"country":211,"year":13,"amount":212,"abstract":213},"cordis-european-research-council-award-101117824","Explaining Individual Lifespan Change","HASKOLI ISLANDS","IS","€1,499,000","The EILisCh project will focus on linguistic variation and change in Icelandic syntax and it will be the most ambitious attempt so far to model, understand, and explain Individual Lifespan Change in linguistic behavior, drawing on recent advances in sociolinguistics, quantitative syntactic theory, clinicial linguistics, as well as resources recently made available by Language Technology. The project will harness these ingredients and the experience of the PI and the infrastructure present in his",{"id":215,"funder":7,"programme":8,"title":216,"piName":10,"institution":217,"country":26,"year":13,"amount":218,"abstract":219},"cordis-european-research-council-award-101041885","The Origins of Human Rhythm","UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA","€1,496,294","Humans are particularly rhythmic animals. Why did the human sense of rhythm develop? Many hypotheses try to explain the origins of our acoustic rhythm capacities, but few are empirically tested, compared, and comparatively investigated. This project searches for the evolutionary roots of human rhythmicity, breaking new ground through three concerted approaches. First, I zoom in on key rhythmic properties: isochrony, an even occurrence of events in time, and meter, a relative accentuation of even",{"id":221,"funder":7,"programme":8,"title":222,"piName":10,"institution":223,"country":76,"year":13,"amount":224,"abstract":225},"cordis-european-research-council-award-101115353","INnovative TRiggEr techniques for beyond the standard model PhysIcs Discovery at the LHC","UNIVERSIDAD DE OVIEDO","€1,499,375","The discovery of the Higgs boson at the Large Hadron Collider (LHC) closes a central chapter of the standard model (SM) of particle physics while raising several questions, such as the nature of dark matter, an explanation to neutrino masses, or the origin of baryon asymmetry in the Universe. The answer to those questions could be linked to the production of beyond the SM (BSM) particles which may have long lifetimes, compared to SM particles at the weak scale. If these long-lived particles (LLP",{"id":227,"funder":7,"programme":8,"title":228,"piName":10,"institution":229,"country":155,"year":13,"amount":230,"abstract":231},"cordis-european-research-council-award-101041696","The Hardness of Finding Good Algorithms","FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA","€1,498,664","This is a project in Computational Complexity. The project aims to answer the following question:     How hard is it to find a good algorithm for a given computational problem?This question can be asked in several different settings, depending on what one means by algorithm (what is the computational model?), computational problem (is it a decision problem? a search problem? a communication problem?), and by good (do we want an algorithm that uses little time? little memory? few logical gates?).",{"id":233,"funder":7,"programme":8,"title":234,"piName":10,"institution":204,"country":100,"year":13,"amount":27,"abstract":235},"cordis-european-research-council-award-101116532","Enantioselective screw-dislocation-mediated growth of chiral nanocrystals","In many scientific disciplines structural symmetry considerations are key. Specifically, mechanisms by which symmetry translates from atomic and molecular building blocks to crystal structures and shapes attract a great deal of attention. A fascinating aspect of this is related to chirality. Louis Pasteurs monumental work, reported in 1848, on formation of chiral shapes in crystals made from chiral molecules, led to an intuition that chiral building blocks naturally lead to chiral shapes in crys",{"id":237,"funder":7,"programme":8,"title":238,"piName":10,"institution":181,"country":12,"year":13,"amount":239,"abstract":240},"cordis-european-research-council-award-101116713","Cryptographic Foundation for Secure and Scalable Distributed Systems","€1,416,204","Many of today’s criticaMany of today’s critical infrastructures such as power grids or cellular networks are distributed systems which arecomprised of autonomous nodes connected over a network. To avoid single points of failure, a central goal indistributed systems is to implement such systems in a fault-tolerant manner. Fault-tolerant systems remain secure andavailable even if some minority of nodes crash or spread incorrect information. To improve robustness and scalability,cutting-edge system",{"id":242,"funder":7,"programme":8,"title":243,"piName":10,"institution":244,"country":12,"year":13,"amount":245,"abstract":246},"cordis-european-research-council-award-101115742","FunctIonal optoacousticS for imaging Early onsEt of Gut inflammation","UNIVERSITATSKLINIKUM ERLANGEN","€1,453,730","The aim of this project is to functionalize contrast agents for multispectral optoacoustic tomography (MSOT) - a molecular sensitive ultrasound imaging technique - to develop a new targeted imaging approach for the early localisation of inflammatory processes.Inflammatory processes in the gastrointestinal tract often act like a Trojan horse - while camouflaging themselves with diffuse clinical symptoms, they may rapidly progress into life-threatening complications. To date, it has been difficult",{"id":248,"funder":7,"programme":8,"title":249,"piName":10,"institution":250,"country":155,"year":13,"amount":251,"abstract":252},"cordis-european-research-council-award-101116569","Trafficking mechanisms and physiological factors mediating a direct gut microbiota-brain neuron interaction","FUNDACAO GIMM - GULBENKIAN INSTITUTE FOR MOLECULAR MEDICINE","€1,875,000","The gut-brain axis has emerged as a complex regulator of system-wide physiology, playing essential roles to maintain homeostasis, including contributions to brain development and activity, affecting host metabolism and behavior. The gut bacterial composition constantly fluctuates, allowing for the regular release of diverse microbe-derived compounds into the bloodstream. Although it is known that many gut-bacterial metabolites affect distant organs such as the brain, their direct interaction wit",{"id":254,"funder":7,"programme":8,"title":255,"piName":10,"institution":256,"country":162,"year":13,"amount":257,"abstract":258},"cordis-european-research-council-award-101117433","Chip-based room-temperature terahertz frequency comb spectrometers","POLITECHNIKA WROCLAWSKA","€1,499,995","Although visual perception of humans is limited to a fraction of wavelengths spanning the electromagnetic spectrum, technological advances enable us to see in other spectral regions by providing suitable sources and detectors. Of particular interest for many applications is the ability to probe objects in the terahertz (THz) range, which bridges the microwave and infrared domains. THz radiation offers unique opportunities for imaging or sensing due to its high transmission by optically-opaque ma",{"id":260,"funder":7,"programme":8,"title":261,"piName":10,"institution":262,"country":100,"year":13,"amount":263,"abstract":264},"cordis-european-research-council-award-101116032","Precision measurement of parity violation with quantum-controlled and trapped chiral molecular ions","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","€1,874,500","Molecular chirality plays a central role in many fields, ranging from reaction dynamics to drug development. Fundamental questions surround chiral molecules, in particular: Why does a specific handedness prevail in natural living systems? The vast majority of Chemistry textbooks define the two enantiomers of chiral molecules as perfect mirror images, which entails tunnelling conversion between enantiomers. However, a closer look reveals that the non-conservation of spatial inversion exhibited by",{"id":266,"funder":7,"programme":8,"title":267,"piName":10,"institution":268,"country":76,"year":13,"amount":27,"abstract":269},"cordis-european-research-council-award-101117639","Isotopically labelling of cell surface glycans to illuminate infectious processes at atomic resolution","ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS","Every human cell is covered by a dense coat of glycans (sugars, carbohydrates). Sugars are the first molecules that viruses encounter when they approach host cells. Many viruses encode lectins to adhere to the outer glycan layer and start infection. In this scenario, Glycoscience holds a tremendous potential for combating infections. Elucidating the molecular basis of infection is essential, but far from trivial. The complexity of the chemistry of glycans, including synthesis, structure, conform",{"id":271,"funder":7,"programme":8,"title":272,"piName":10,"institution":273,"country":26,"year":13,"amount":274,"abstract":275},"cordis-european-research-council-award-101117299","Macroscopic properties of interacting bosons: a unified approach to the Thermodynamic Challenge","GRAN SASSO SCIENCE INSTITUTE","€1,499,004","Interacting bosons are unique quantum systems, whose low temperature phases exhibit fascinating quantum mechanics effects at a macroscopic scale. In the past two decades, the mathematical understanding of these systems improved tremendously. However, their behavior in the thermodynamic limit is still poorly understood, although this is the appropriate large scale limit to prove the emergence of scaling laws and universality, as well as to investigate the occurrence of phase transitions. MaTCh ai",{"id":277,"funder":7,"programme":8,"title":278,"piName":10,"institution":279,"country":12,"year":13,"amount":280,"abstract":281},"cordis-european-research-council-award-101042567","Linguistic Tuning Shifts in the Human Brain during Second Language Learning","TECHNISCHE UNIVERSITAT BERLIN","€1,499,885","Language learning and fostering linguistic diversity within the European Union are priorities of the European Commission. Learning new languages can change the structure and function of the cerebral cortex, affecting the way we think. However, despite extensive research, we lack a fine-grained description of how dynamical changes in cortical representations mediate learning concepts and linguistic structures of a new language. The LINGSHIFT program will use a cutting-edge paradigm to identify th",{"id":283,"funder":7,"programme":8,"title":284,"piName":10,"institution":285,"country":12,"year":13,"amount":286,"abstract":287},"cordis-european-research-council-award-101116722","Practical magnesium batteries enabled by 2D crystalline polymer-based artificial electrode skins","TECHNISCHE UNIVERSITAET DRESDEN","€1,499,900","The intrinsic limitation of Li-ion batteries (i.e., cost, safety, and sustainability) is imposing a strong demand for next-generation battery technologies based on resource-abundant elements. Among the top candidates for this purpose are Mg batteries. However, state-of-the-art Mg batteries still encounter numerous problems (e.g., low Coulombic efficiency, energy efficiency, energy density, and cycle life) and are far from mature to satisfy practical use. The disappointing performance of Mg batte",{"id":289,"funder":7,"programme":8,"title":290,"piName":10,"institution":187,"country":76,"year":13,"amount":10,"abstract":291},"cordis-european-research-council-award-101041853","Truth in Ancient and Medieval Philosophy","While it is sometimes suggested that we are living in a 'post-truth' age wherein the concept of truth is increasingly less relevant, truth nonetheless remains a central concept in science, ethics, and ordinary life. However, what precisely is truth? One common view, the so-called 'correspondence theory of truth', maintains that truth is simply correspondence with the facts. However, such a view faces a number of difficulties and potential objections. For instance, what exactly is correspondence?",{"id":293,"funder":7,"programme":8,"title":294,"piName":10,"institution":295,"country":100,"year":13,"amount":27,"abstract":296},"cordis-european-research-council-award-101112713","Verifiably Safe and Correct Deep Neural Networks","THE HEBREW UNIVERSITY OF JERUSALEM","Deep machine learning is revolutionizing computer science. Instead of manually creating complex software, engineers now use automatically generated deep neural networks (DNNs) in critical financial, medical and transportation systems, obtaining previously unimaginable results.Despite their remarkable achievements, DNNs remain opaque. We do not understand their decision making and cannot prove their correctness - thus risking potentially devastating outcomes. For example, it has been shown that D",{"id":298,"funder":7,"programme":8,"title":299,"piName":10,"institution":300,"country":26,"year":13,"amount":301,"abstract":302},"cordis-european-research-council-award-101042882","The world behind a word. An anthropological exploration of fascist practices and meanings among European youth.","UNIVERSITA DEGLI STUDI DI TORINO","€1,114,266","How and why does the “f-word” of fascism continue to constitute a compelling and urgent issue in contemporary Europe? F-WORD addresses this question through comparative ethnographic research among martial arts and combat sports sites as contexts for exploring how fascist practices and meanings are diffused and appropriated by youth. Using fascism as a heuristic device, this project also unfolds diachronically, seeking to explore how European history and memory politics are practiced in the daily",{"id":304,"funder":7,"programme":8,"title":305,"piName":10,"institution":306,"country":100,"year":13,"amount":307,"abstract":308},"cordis-european-research-council-award-101116423","Second Nature: Towards an Information-Processing Theory of the Reification of Social Reality","TEL AVIV UNIVERSITY","€1,499,465","Social reality is comprised of numerous social constructs such as institutions, practices, and norms. These constructs are mind-dependent (e.g., paper money is valuable because people believe it is). Research suggests that when people misconstrue social constructs to be mind-independent facts (e.g., viewing inequality as a fact of nature), they are less likely to question their legitimacy. Thus, the attribution of mind-independence to social constructs, or reification, plays a critical role in g",{"id":310,"funder":7,"programme":8,"title":311,"piName":10,"institution":312,"country":313,"year":13,"amount":27,"abstract":314},"cordis-european-research-council-award-101116228","Unravelling unsteady fluid flows in porous media with 3D X-ray micro-velocimetry","UNIVERSITEIT GENT","BE","Models of fluid flows in porous materials commonly fall short because they fail to capture the effects of the puzzling underlying microscopic dynamics. These flows are very common: examples range from groundwater flow and H2 storage in underground rocks to water discharge in fuel cells. The fluctuating, microscopic dynamics are poorly understood because they have so far been inaccessible in the 3D labyrinths formed by pore geometries, hampered by the optical opacity of the materials. In FLOWSCOP",{"id":316,"funder":7,"programme":8,"title":317,"piName":10,"institution":175,"country":33,"year":13,"amount":318,"abstract":319},"cordis-european-research-council-award-101041249","Singularities and symplectic mapping class groups","€1,474,995","Symplectic topology is a central part of modern geometry, with historical roots in classical mechanics. Symplectic structures also arise naturally in low-dimensional topology, in representation theory, in the study of moduli spaces of algebraic varieties, and in quantum mechanics. A fundamental question is to understand the automorphisms of a symplectic manifold. The most natural ones are symplectomorphisms, i.e., diffeomorphisms preserving the symplectic structure. I propose to study structural",{"id":321,"funder":7,"programme":8,"title":322,"piName":10,"institution":295,"country":100,"year":13,"amount":323,"abstract":324},"cordis-european-research-council-award-101116390","Mean curvature flow: singularity formation beyond 2 convexity and applications","€1,499,138","Geometric flows as a mean to attack problems in topology, geometry and physics, had been demonstrated to be an extremely powerful tool. The most successful such flow to date is the Ricci flow (RF), which was used in the proof of the geometrization conjecture. The mean curvature flow (MCF) - the most natural geometric flow for sub-manifolds in an ambient space, had also been successfully applied to address such problems. Nevertheless, the most striking potential applications of MCF are still out ",{"id":326,"funder":7,"programme":8,"title":327,"piName":10,"institution":328,"country":26,"year":13,"amount":329,"abstract":330},"cordis-european-research-council-award-101116966","Social Media: Measuring Effects and Mitigating Downsides","UNIVERSITA COMMERCIALE LUIGI BOCCONI","€1,494,625","Social media was initially expected to generate widespread improvements in individual well-being and to have positive externalities in the political domain. Such optimistic expectations soon gave way to a host of concerns about possible negative effects of social media. At the societal level, many started worrying that social media might exacerbate political polarization and propagate misinformation. At the level of individual users, many became concerned that social media might have detrimental",{"id":332,"funder":7,"programme":8,"title":333,"piName":10,"institution":262,"country":100,"year":13,"amount":224,"abstract":334},"cordis-european-research-council-award-101117737","Toward a new understanding of learning in the brain: dynamic parallel circuit loops for complex learning","The brain’s ability to learn is arguably its most exceptional capacity. Learning in biological brains far surpasses machine learning and requires much less training. How does the brain accomplish this? Why is biological learning still better than the most advanced machine learning algorithms to date? According to the standard model of reward-based learning in the brain, a single error signal is broadcast from the dopamine system and used to update the entire network, implementing a simple form o",{"id":336,"funder":7,"programme":8,"title":337,"piName":10,"institution":338,"country":26,"year":13,"amount":339,"abstract":340},"cordis-european-research-council-award-101041620","Diamonds as the key to unravel the origin of Earth's water","UNIVERSITA DEGLI STUDI DI PADOVA","€1,499,758","The origin Earth's water is still an unsolved mystery in Earth Sciences. Yet, answering this question is paramount in order to validate planetary accretion models and determine the conditions for life-sustainable planets to form. Comparing Earth's original deuterium-to-hydrogen ratio (D\u002FH) with those of Solar system objects such as meteorites, comets and the solar nebula can constrain on the provenance of water. However, while D\u002FH is precisely determined for extra-terrestrial objects, the exact ",{"id":342,"funder":7,"programme":8,"title":343,"piName":10,"institution":344,"country":57,"year":13,"amount":27,"abstract":345},"cordis-european-research-council-award-101039222","SUrrogate measures for SAFE autonomous and connected mobility","LUNDS UNIVERSITET","SUperSAFE SUrrogate measures for SAFE autonomous and connected mobility will address the problem of the safety evaluation of the interaction between conventional vehicles and connected and automated vehicles (CAVs). The project builds on the notion that vehicle automation is posing new risks that the traditional accident-based and proactive safety analysis methods are unable to investigate. In SUperSAFE, I will select the relevant variables drew on the newly identified risks posed by CAVs, and w",{"id":347,"funder":7,"programme":8,"title":348,"piName":10,"institution":349,"country":313,"year":13,"amount":10,"abstract":350},"cordis-european-research-council-award-101040858","Early warning of future rapid Arctic sea ice loss","UNIVERSITE CATHOLIQUE DE LOUVAIN","The Arctic is currently transitioning toward a new climatic state that will be characterized by seasonally sea-ice-free conditions almost every year from the 2050s, with widespread ecological, climatic, and societal consequences. There is growing evidence that the future summer sea ice retreat will not occur at a constant rate. Indeed, climate model simulations are suggestive of pronounced sub-decadal fluctuations on top of the long-term trend, leading to periods of relative stability followed b",{"id":352,"funder":7,"programme":8,"title":353,"piName":10,"institution":354,"country":40,"year":13,"amount":355,"abstract":356},"cordis-european-research-council-award-101041077","Quantifying the completeness of the stratigraphic record and its role in reconstructing the tempo and mode of evolution","UNIVERSITEIT UTRECHT","€1,497,169","Darwin identified the incompleteness of the geological record as a major concern in our ability to reconstruct the evolutionary history from fossils. Geological strata are not, however, a random selection of the past, but are deposited and preserved in processes which can be modelled mathematically. This project employs numerical forward modelling, a technique from sedimentary basin analysis, to quantify how stratigraphic gaps affect evolutionary patterns in the fossil record. It focuses on trop",{"id":358,"funder":7,"programme":8,"title":359,"piName":10,"institution":360,"country":12,"year":13,"amount":361,"abstract":362},"cordis-european-research-council-award-101042703","Media, Economics and Geopolitics","RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN","€1,496,833","Research in political economy has documented a vast number of different media effects suggesting that the media can have a profound impact on a range of economically & politically relevant outcomes. Yet, the existing empirical work is significantly skewed towards a few countries, raising concerns about the generalizability & broader cross context relevance of the empirical findings. Further, given the predominant focus on individual countries and its politics, this implies limited attention is d",{"id":364,"funder":7,"programme":8,"title":365,"piName":10,"institution":366,"country":12,"year":13,"amount":10,"abstract":367},"cordis-european-research-council-award-101040059","Humour as an epistemic practice of the political present","JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN","Something weird is happening in politics. Satirical parties, comedic journalism and memeification are gaining more and more traction; the slippages between parody and sincerity, play and earnestness, real and fake, ridicule and seriousness have proliferated at a dizzying rate. Global entanglements, new technologies, and the surge in populist politics are producing a cacophony of intricate cognitive, social, and economic dissonances bordering on the absurd. The underlying hypothesis of NoJoke is ",{"id":369,"funder":7,"programme":8,"title":370,"piName":10,"institution":371,"country":12,"year":13,"amount":27,"abstract":372},"cordis-european-research-council-award-101115122","Discovering neutrinos of extreme energies with the Radio Neutrino Observatory Greenland","DEUTSCHES ELEKTRONEN-SYNCHROTRON DESY","The discovery of neutrinos above energies of 1e16 eV promises to uncover: the unknown sources of ultra-high energy cosmic rays, new insights into astrophysics of these sources and particle propagation through the Universe, as well as new particle physics, at energies far higher than those accessible to man-made accelerators. The Radio Neutrino Observatory Greenland (RNO-G) is currently under construction and is scheduled to reach 35 stations in 2026. The in-ice radio array RNO-G is the first lar",{"id":374,"funder":7,"programme":8,"title":375,"piName":10,"institution":376,"country":377,"year":13,"amount":378,"abstract":379},"cordis-european-research-council-award-101040153","Inverse Design of Optoelectronic Phosphosulfides","DANMARKS TEKNISKE UNIVERSITET","DK","€2,263,750","Progress in sustainable energy technology relies on the discovery of new earth-abundant materials with unprecedented ability to conduct ions, catalyze reactions, transport photogenerated carriers, etc. The main scientific question is how to find the materials with exactly the desired functionality from the huge pool of all possible materials (more than 10^12).In IDOL, we will attempt to answer the long-standing question of inverse materials design. Our targeted functionality is high optoelectron",{"id":381,"funder":7,"programme":8,"title":382,"piName":10,"institution":383,"country":33,"year":13,"amount":384,"abstract":385},"cordis-european-research-council-award-101042881","Bioorthogonal Cascade-Targeting: Directing Drugs into Cells with Molecular Precision","TECHNISCHE UNIVERSITAET WIEN","€1,479,321","Bioorthogonal chemistries cross the boundaries between static chemical connectivity and the dynamic physiologic regulation of molecular state, enabling powerful tools for molecular control in complex biological environments. In combination with ligand-directed drug delivery, safe and selective chemical reactions that perform efficiently in vivo can fuel the design of new therapeutic strategies. Despite significant progress in the field of drug targeting, it remains challenging to shuttle therape",{"id":387,"funder":7,"programme":8,"title":388,"piName":10,"institution":389,"country":12,"year":13,"amount":390,"abstract":391},"cordis-european-research-council-award-101116680","New Trends of Non-Hermitian Topology in Open and Correlated Quantum Systems","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","€1,496,250","Non-Hermiticity plays a central role in describing open systems, which in recent years has been investigated in the context of topology revealing a dramatic enrichment of the phenomenology of topological phases. A particular focus has been on the appearance of truly non-Hermitian (NH) degeneracies known as exceptional points (EPs) at which not only the eigenvalues but also the eigenvectors coalesce. In their most elementary form, EPs reveal intriguing phenomena, such as unidirectional transmissi",{"id":393,"funder":7,"programme":8,"title":394,"piName":10,"institution":395,"country":125,"year":13,"amount":396,"abstract":397},"cordis-european-research-council-award-101117204","Life of Giant Phages","JYVASKYLAN YLIOPISTO","€1,499,808","Bacterial viruses, phages, are ubiquitous and most numerous entities in the biosphere. Development of sequencing techniques has increased our understanding on the diversity of phages that have not been isolated due to lack of cultivable hosts and\u002For suitable isolation methods. While sequence data enables a better view to the viral diversity, at the same time lack of functional data and biological connection increases. Recently, different studies have found megaphages (mainly phages with a genome",{"id":399,"funder":7,"programme":8,"title":400,"piName":10,"institution":354,"country":40,"year":13,"amount":27,"abstract":401},"cordis-european-research-council-award-101039426","Balancing clean Water and Energy provision under changing climate and eXtremes","Providing clean water and energy simultaneously to a growing global population and under a changing climate is a major challenge. The demand for the two and their systemic interdependencies are particularly strong during droughts and heatwaves. Despite the recent growth in water-energy nexus studies, there is little fundamental understanding of the cascading effects and feedbacks between water and energy systems during extreme weather events. Because existing global model approaches mainly focus",{"id":403,"funder":7,"programme":8,"title":404,"piName":10,"institution":405,"country":40,"year":13,"amount":27,"abstract":406},"cordis-european-research-council-award-101042634","Deciphering signalling pathway dynamics during cell-fate commitment in stem cells","ACADEMISCH ZIEKENHUIS LEIDEN","Understanding the identity and intensity of the specific extracellular signals that a cell experiences at different times during its differentiation is essential to develop advanced cellular therapies. However, uncovering the sequence of these signaling events, their intensities, timing, and relevance in development and disease is proving to be very challenging.Here, I propose to build i-SignalTrace: a CRISPR\u002FCas9-based molecular recorder with the capacity to store both lineage information and s",{"id":408,"funder":7,"programme":8,"title":409,"piName":10,"institution":410,"country":12,"year":13,"amount":411,"abstract":412},"cordis-european-research-council-award-101041743","VERTical EXchange in the Southern Ocean","ALFRED-WEGENER-INSTITUT HELMHOLTZ-ZENTRUM FUR POLAR- UND MEERESFORSCHUNG","€1,499,464","Mitigating global climatic changes due to human influences is of paramount importance in the coming decades. Historically, the global ocean has played a critical role in this process by taking up the majority of the excess heat and about 30% of the anthropogenic carbon-dioxide (CO2) emissions from the atmosphere. The largest share of this uptake process occurred through the subduction of waters in the Southern Ocean that sequester heat and carbon in deeper layers of the ocean. Yet, global climat",{"id":414,"funder":7,"programme":8,"title":415,"piName":10,"institution":416,"country":40,"year":13,"amount":417,"abstract":418},"cordis-european-research-council-award-101042724","Identifying Atherosclerotic Plaques at Risk:  A Microstructure-based Biomechanistic Approach","ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM","€1,879,625","Atherosclerotic plaque rupture in arteries is the primary cause of cardiovascular events such as heart infarct and stroke, which are responsible for 45% of deaths in Europe. Plaque rupture is a mechanical event, where the collagenous plaque tissue fails to withstand blood pressure loading. Identifying plaques at high risk of rupture is the key to prevent these fatal events. However, the current risk assessment strategy fails to achieve this as it lacks mechanistic insights into tissue failure. T",{"id":420,"funder":7,"programme":8,"title":421,"piName":10,"institution":422,"country":40,"year":13,"amount":423,"abstract":424},"cordis-european-research-council-award-101042844","Engineered Porous Electrodes to Unlock Ultra-low Cost Fe-Air Redox Flow Batteries","TECHNISCHE UNIVERSITEIT EINDHOVEN","€1,999,958","This proposal will develop a game-changing paradigm to design, synthesize, and functionalize porous electrode materials with far-reaching consequences in electrochemical science and engineering. Focusing on the Fe-air redox flow battery (FAIR-RFB), which holds promise for low-cost, long duration energy storage, I will employ an interdisciplinary approach bridging (electro)chemical engineering, materials science, and computational design to address the following fundamental challenges: (1) I will",{"id":426,"funder":7,"programme":8,"title":427,"piName":10,"institution":344,"country":57,"year":13,"amount":428,"abstract":429},"cordis-european-research-council-award-101042247","Towards a theory of endings in innovation studies","€1,482,076","Because innovations are important to achieve sustainable development, substantial investments have been made in innovation research. Yet, innovations often prove insufficient for replacing established production and consumption practices. In ENDINGS, I argue that we need to overcome this innovation bias by studying how existing socio-technical systems and their respective knowledge bases end – or not. In fact, evidence suggests that it is more likely for existing systems to endure than to disapp",{"id":431,"funder":7,"programme":8,"title":432,"piName":10,"institution":389,"country":12,"year":13,"amount":27,"abstract":433},"cordis-european-research-council-award-101113633","Nonequilibrium Many Body Control of Quantum Simulators","The ability to control quantum matter in a state of equilibrium is a milestone of 20th-century physics. A major goal of modern physics is to extend this knowledge to out-of-equilibrium systems. Located at the boundary between equilibrium and nonequilibrum, quantum simulation appears particularly suitable for this purpose. Using periodic drives, quantum simulators can experimentally emulate phenomena hitherto inaccessible in conventional materials, such as artificial gauge fields or topological a",{"id":435,"funder":7,"programme":8,"title":436,"piName":10,"institution":437,"country":57,"year":13,"amount":438,"abstract":439},"cordis-european-research-council-award-101041284","Things for Politics' Sake: Aesthetic Objects and Social Change","GOETEBORGS UNIVERSITET","€1,499,586","THINGSTIGATE aims to theorize how aesthetic objects mediate sociopolitical transformation. In a world where affective imagination increasingly sways society and politics, it is urgent to grasp the link between imagination, emotions, and sociopolitical institutions. Art for social change, ‘socially engaged art’, is pertinent, but its theories now dwell on usefulness. Imbued in a post-object relational art tradition despite the material turn in humanities and social sciences, these theories overlo",{"id":441,"funder":7,"programme":8,"title":442,"piName":10,"institution":443,"country":377,"year":13,"amount":182,"abstract":444},"cordis-european-research-council-award-101117373","The Chromite Record of Mafic Crustal Growth","KOBENHAVNS UNIVERSITET","Understanding Earth's crustal growth is crucial to understanding the evolution of its tectonics, the birth of the first continents, and the fundamental changes that transformed Earth into a habitable planet. However, much of our understanding of Earth's crustal growth is predicated on a single mineral - zircon - that is strongly biased towards detecting felsic crustal growth. This is particularly problematic for the early Earth, where average crustal compositions were far more mafic than today, ",{"id":446,"funder":7,"programme":8,"title":447,"piName":10,"institution":99,"country":100,"year":13,"amount":448,"abstract":449},"cordis-european-research-council-award-101116636","Occurrence, Regulation, and Function of Bacterial mRNA Editing Under Diverse Environments","€1,749,998","Bacteria are haploid, having a single copy of each gene. We suggest a paradigm shift in bacterial genetics: bacteria can have two RNA versions of the same gene, encoding protein isoforms at the single-bacterium and population level. These protein isoforms can have altered activity, which could be advantageous under different conditions.Adenosine-to-inosine (A-to-I) mRNA editing can affect the sequence and the function of translated proteins because the ribosome identifies inosine as guanosine. W",{"id":451,"funder":7,"programme":8,"title":452,"piName":10,"institution":453,"country":454,"year":13,"amount":455,"abstract":456},"cordis-european-research-council-award-101039339","Spatio-temporal shaping of electron wavepackets for time-domain electron holography","UNIVERZITA KARLOVA","CZ","€1,835,895","Advanced techniques of electron microscopy and spectroscopy require tools, which enable to control various degrees of freedom of electron beams (phase profile, temporal structure, orbital angular momentum, etc.). The inelastic quantum coherent interaction between light waves and electron wavepackets allows to structure the temporal probability distribution of electrons with attosecond precision, which may enable probing the coherent dynamics of optical excitations or plasmonic near-fields of nan",{"id":458,"funder":7,"programme":8,"title":459,"piName":10,"institution":460,"country":461,"year":13,"amount":438,"abstract":462},"cordis-european-research-council-award-101041343","Spectres & Camouflage: The Sound of Silence (1938-1970)","UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN","IE","Silence is a rare - often beautiful, sometimes discomfiting - phenomenon. Harnessed in different manners, silence has multiple cultural, societal, scientific, psychological, artistic and military implications. In the 20th C., the impact and exploitation of silence manifested in the technological search for the soundless environment: a search which centred upon environmental control and design. It was shaped by disciplinary and international transfers of knowledge. Ultimately, the technology beca",{"id":464,"funder":7,"programme":8,"title":465,"piName":10,"institution":466,"country":76,"year":13,"amount":467,"abstract":468},"cordis-european-research-council-award-101040193","Controlling Oxygen Selectivity at the Atomic Scale","UNIVERSIDAD DEL PAIS VASCO\u002F EUSKAL HERRIKO UNIBERTSITATEA","€2,345,000","Developing new materials with optimized catalytic properties is a crucial challenge towards sustainable energy production. In order to achieve this long-standing goal, fundamental understanding of the processes taking place at the electrode-electrolyte interface is vital. Progress here requires a comprehensive atomic-scale picture of the fundamental chemical and catalytic properties of surfaces, in connection to their macroscopic catalytic performance. This knowledge remains hindered due to the ",{"id":470,"funder":7,"programme":8,"title":471,"piName":10,"institution":472,"country":125,"year":13,"amount":473,"abstract":474},"cordis-european-research-council-award-101039583","Microbial ecosystems biology in the human gut","HELSINGIN YLIOPISTO","€1,485,413","The gut microbiota has wide-ranging effects on host health and represents a promising target for therapeutic manipulation, particularly in early life. Imbalances in the gut microbiota precede the dThe gut microbiota has wide-ranging effects on host health and represents a promising target for therapeutic manipulation, particularly in early life. Imbalances in the gut microbiota precede the development of conditions such as overweight and immunological diseases, which exert a significant burden o",{"id":476,"funder":7,"programme":8,"title":477,"piName":10,"institution":312,"country":313,"year":13,"amount":478,"abstract":479},"cordis-european-research-council-award-101040374","The Ethics of Loneliness and Sociability","€1,025,860","Loneliness, which can be defined as the negative mental states (e.g. sadness, despair) that people experience when they feel that they do not have enough relationships, or not the right kinds of relationships, is a widespread phenomenon in many societies. Even prior to the current pandemic, surveys from Europe and North-America reported that 20 to 35 percent of adults between the ages of 65 and 79 say that they are frequently lonely, a figure that rises to 40 to 50 percent among those aged 80 an",{"id":481,"funder":7,"programme":8,"title":482,"piName":10,"institution":483,"country":12,"year":13,"amount":484,"abstract":485},"cordis-european-research-council-award-101039115","Next generation mechanistic models of retinal interneurons","EBERHARD KARLS UNIVERSITAET TUEBINGEN","€1,499,860","Ever since the work Hodgkin and Huxley, models of neurons have been essential for our understanding of neural computations. Such models have been developed at diverse levels of realism, from linear-nonlinear cascade or black-box models to detailed compartmental models. While these approaches are commonly viewed as incompatible, they have attractive strengths from an epistemic point of view. In this project, I propose to develop a new generation of hybrid mechanistic models that reconcile these l",{"id":487,"funder":7,"programme":8,"title":488,"piName":10,"institution":389,"country":12,"year":13,"amount":489,"abstract":490},"cordis-european-research-council-award-101114879","How to evolve without centromeres: meiotic recombination dynamics in holocentric plants","€1,499,980","Centromeres strongly affect genomic architecture and meiotic recombination distribution and also play a key role in constraining karyotype evolution. The recombination landscape is also heavily influenced by chromosome number and structure (i.e., karyotypes), as at least one crossover per chromosome (and rarely more than three) occurs in most species, making chromosome number the primary driver of recombination frequency. In addition, centromeres inhibit recombination, and therefore crossovers t",{"id":492,"funder":7,"programme":8,"title":493,"piName":10,"institution":250,"country":155,"year":13,"amount":494,"abstract":495},"cordis-european-research-council-award-101043068","The impact of germline metabolic reprogramming on reproduction and physiology","€1,481,513","Animals are composed of multiple tissues with different metabolic needs. During differentiation, the establishment of specific metabolic programs allows cells to acquire specialized functions. The nutrients that fuel these cell-specific metabolic pathways are obtained via the diet. In order to secure proper nutrient supply to these tissues, the central nervous system accesses their metabolic states, allowing the animal to mount behavioral strategies to adapt nutrient appetite. Our understanding ",{"id":497,"funder":7,"programme":8,"title":498,"piName":10,"institution":11,"country":12,"year":13,"amount":499,"abstract":500},"cordis-european-research-council-award-101040409","Non-Hermitian Topological Physics in Grand Canonical Photon Lattices","€1,498,750","Topology is a powerful paradigm for the classification of phases of matter. One of its direct manifestations in the widely studied Hermitian systems, which are isolated from the environment, are robust states that emerge at the interfaces between matter with distinct topological order. Real systems, however, are never truly isolated from their surroundings and the influence of the environment on the topologically protected states remains to a large extent unknown. Even more importantly, understa",{"id":502,"funder":7,"programme":8,"title":503,"piName":10,"institution":262,"country":100,"year":13,"amount":504,"abstract":505},"cordis-european-research-council-award-101116361","Hidden in the Noise: Transient Details of Nanoparticle-Catalyzed Reactions Under Challenging Conditions","€1,812,500","Metal nanoparticle-based catalysts drive our chemical industry and will be an essential tool to shift away from fossil-resources. Despite their exigence, new catalysts are often still found by trial and error rather than designed rationally. Although recent fundamental studies from our own research and others yield important new insights, there is a lack of methodology to investigate the subtle transient details missing in our understanding at the very high pressures that are often industrially ",{"id":507,"funder":7,"programme":8,"title":508,"piName":10,"institution":509,"country":76,"year":13,"amount":510,"abstract":511},"cordis-european-research-council-award-101041659","Unraveling the Functional Complexity of Cancer Genomes through Chromosome Engineering","FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON (VHIO)","€1,604,375","Cancers arise through genetic and epigenetic alterations that drive the transformation of single cells into malignant tumors. Among genetic changes, copy number alterations (CNAs) are recurrent chromosomal events that increase or decrease the dosage of specific regions of DNA, can affect up to 30% of a cancer cell genome, and are associated with poor clinical outcomes. Despite their pervasiveness, the functional effects of specific CNAs on cancer phenotypes remain largely unknown, as current app",{"id":513,"funder":7,"programme":8,"title":514,"piName":10,"institution":515,"country":40,"year":13,"amount":516,"abstract":517},"cordis-european-research-council-award-101042699","Roman Making and its Meanings: Representations of Manual Creation in the Literature and Art of Imperial Rome","RIJKSUNIVERSITEIT GRONINGEN","€1,499,999","How did the ancient Romans respond to the material world around them? This project, FACERE, proposes a new way of approaching this question. It studies ‘making’ – the processes by which the objects and buildings which surrounded Romans in their daily lives were produced. How things were made in ancient Rome is usually studied as a practical or technical process. However, making also has a wide range of culturally specific aesthetic and moral implications. FACERE breaks new ground by asking not h",{"id":519,"funder":7,"programme":8,"title":520,"piName":10,"institution":521,"country":33,"year":13,"amount":10,"abstract":522},"cordis-european-research-council-award-101041206","The function of B cells in myocardial infarction-accelerated atherosclerosis","MEDIZINISCHE UNIVERSITAET WIEN","Survivors of acute myocardial infarction (MI) are at a particularly high risk for accelerated atherosclerosis and recurrent atherothromobosis. Nevertheless, mechanistic preclinical studies in atherosclerosis research world-wide are typically conducted in unchallenged (without MI) atherosclerosis-prone mice and thus do not address the specific pathophysiology of post-MI atherosclerotic cardiovascular disease. We conducted a single-cell RNA sequencing coupled to B cell receptor (BCR) sequencing an",{"id":524,"funder":7,"programme":8,"title":525,"piName":10,"institution":389,"country":12,"year":13,"amount":526,"abstract":527},"cordis-european-research-council-award-101116848","Development of Reconstructed Electron Energy Loss techniques for Elemental Mapping in macromolecular structures","€1,723,334","A perfect macromolecular structure would provide an all-atom description of the molecule, including not only the well-ordered polypeptide or polynucleotide framework but all other species: metals and other ions, cofactors, lipids, substrates and inhibitors. However, current structural data include no or very little information on elemental composition, leading to significant errors and omissions in atomic models. To address this issue, I propose to develop a method, Reconstructed Electron Energy",{"id":529,"funder":7,"programme":8,"title":530,"piName":10,"institution":295,"country":100,"year":13,"amount":531,"abstract":532},"cordis-european-research-council-award-101116444","A Unifying Principle Underlying Social Bonding: Towards a Psycho-Biological Theory","€1,499,875","Imagine a first date, where partners feel an immediate bond, versus an awkward date, where partners feel disconnected. BioBond asks whether there is a biological mechanism that is set to differentially favour bonding in the first date over the second. Despite substantial research on social bonding, we are still without an understanding of what drives social animals to bond and prefer selected individuals. BioBond aims to provide, for the first time, a novel and empirically-validated biological t",{"id":534,"funder":7,"programme":8,"title":535,"piName":10,"institution":536,"country":57,"year":13,"amount":537,"abstract":538},"cordis-european-research-council-award-101042299","Transients Illuminating the Fates of the Most Massive Stars","STOCKHOLMS UNIVERSITET","€1,634,250","Two recent revolutions in time-domain astronomy are transforming our understanding of stellar evolution in the most massive regime: the detections of gravitational waves (GW) from binary black holes, and the discovery of new and rare classes of supernovae from wide-field transient surveys. With this, a long-standing prediction from stellar evolution theory is gaining new relevance: that stars with He cores above ~35 solar masses will encounter an instability due to pair-production, resulting in ",{"id":540,"funder":7,"programme":8,"title":541,"piName":10,"institution":542,"country":12,"year":13,"amount":543,"abstract":544},"cordis-european-research-council-award-101115997","Injectable nanoelectrodes for wireless and minimally invasive neural stimulation","TECHNISCHE UNIVERSITAET MUENCHEN","€1,499,725","Neural devices used in the brain and spinal cord have yielded medical breakthroughs to improve the lives of people with spinal cord injury, Parkinson’s disease, and hearing loss. However, current neural devices are large, complex, and invasive, and are therefore used by only a fraction of people who could benefit from them. Instead, I want to make neural devices that are nanoscale, injectable, and wireless. By lowering invasiveness and implantation risk, this technology could address the unmet m",{"id":546,"funder":7,"programme":8,"title":547,"piName":10,"institution":295,"country":100,"year":13,"amount":548,"abstract":549},"cordis-european-research-council-award-101117931","Systematic mapping of the chloroplast protein import system","€1,700,000","Protein import into a membrane-bound organelle in eukaryotes has been intensively studied, leading to the discovery of the central intracellular import machineries. Yet, this field has undergone a fundamental paradigm shift following recent discoveries of non-canonical import pathways in the mitochondria and ER. While the chloroplast is still thought to have but one import machinery (TIC\u002FTOC), accumulating evidence indicate it, too, has non-canonical pathways. Technological constraints have so f",{"id":551,"funder":7,"programme":8,"title":552,"piName":10,"institution":542,"country":12,"year":13,"amount":553,"abstract":554},"cordis-european-research-council-award-101041375","Commoditizing Data Analytics in the Cloud","€1,498,125","The goal of this project is to commoditize large-scale data analytics in the cloud, which means (a) to reduce query processing cost to close to what the available hardware is theoretically capable of and (b) to prevent vendor lock-in by making it easy to move data between different clouds and systems. To achieve this, we will design and develop an open and cost-efficient analytical database system for the cloud called CODAC.The CODAC system consists of three main components: First, an intelligen",{"id":556,"funder":7,"programme":8,"title":557,"piName":10,"institution":558,"country":76,"year":13,"amount":559,"abstract":560},"cordis-european-research-council-award-101041972","CHerenkov Light mOdulE for time-of-flight Positron Emission Tomography","INSTITUTO DE FISICA DE ALTAS ENERGIAS","€1,384,755","Time-of-flight positron emission tomography (TOF-PET) is the standard-of-care in cancer detection. TOF-PET scanners’ performance is dependent on the radiation detectors they use. Improving time and spatial detection features in such detectors will dramatically impact the diagnostic capacity of TOF-PET systems. The goal of this project is to build a gamma detector concept for TOF-PET able to improve the time resolution and spatial segmentation of state-of-the-art detectors by a factor of up to 7 ",{"id":562,"funder":7,"programme":8,"title":563,"piName":10,"institution":564,"country":26,"year":13,"amount":565,"abstract":566},"cordis-european-research-council-award-101117893","Setting the optimal balance between metabolite supplementation and deprivation in cancer therapy","UNIVERSITA DEGLI STUDI DI MILANO","€1,499,250","The goal of this proposal is to explore combinations of targeted metabolite supplementation and global nutrient restriction as a new strategy to reprogram tumor metabolism, to halt tumor progression and to improve response to treatments. Preclinical and clinical studies published by our group and by others showed that global nutrient restriction, in the form of cyclic fasting or fasting-mimicking diets (FMDs), produces desirable metabolic and immunologic effects that result in reduced tumor prog",{"id":568,"funder":7,"programme":8,"title":569,"piName":10,"institution":542,"country":12,"year":13,"amount":27,"abstract":570},"cordis-european-research-council-award-101076253","Spatial 3D Semantic Understanding for Perception in the Wild","Understanding the 3D spatial semantics of the world around us is core to visual perception and digitization -- real-world environments are spatially three-dimensional, and must be understood in its 3D context, even from 2D image observations. This will lead to spatially-grounded reasoning and higher-level perception of the world around us. Such 3D perception will provide the foundation for transformative, next-generation technology across machine perception, immersive communications, mixed reali",{"id":572,"funder":7,"programme":8,"title":573,"piName":10,"institution":542,"country":12,"year":13,"amount":27,"abstract":574},"cordis-european-research-council-award-101078028","Cell-free synthesis and assembly of biomolecular condensates:  Engineering properties, functions and regulation","Compartmentalization is a defining characteristic of life and has the potential to enable and improve engineered manufacturing routes in biotechnology. Many biomolecules like proteins and RNA have the ability to spontaneously cluster in molecularly dense, phase-separated liquid-like assemblies, termed biomolecular condensates. Biomolecular condensates are promising as synthetic compartments in cell-free reactions and living cells because they could provide programmable, self-assembled spatial or",{"id":576,"funder":7,"programme":8,"title":577,"piName":10,"institution":19,"country":12,"year":13,"amount":578,"abstract":579},"cordis-european-research-council-award-101116823","Spatial Quantification of Cellular Metabolism in the  Tumor Immune Microenvironment","€1,497,756","The success of cancer immunotherapy, especially immune checkpoint inhibition (ICI), demonstrates the ability of the immune system to fight tumors. However, only a fraction of patients benefit from currently available therapies, and we need to find novel approaches to improve clinical responses. Cellular metabolism has emerged as a key determinant of multiple aspects of immune cell function, especially T cell exhaustion and anti-inflammatory macrophage polarization. However, we currently do not h",{"id":581,"funder":7,"programme":8,"title":582,"piName":10,"institution":583,"country":377,"year":13,"amount":584,"abstract":585},"cordis-european-research-council-award-101077000","The Politics of  Citizen Opposition to Urban Development","AARHUS UNIVERSITET","€1,455,684","A central conflict in urban politics lie between those who want cities to change, physically, by embracing ambitious urban development projects, and urban conservationists who oppose such changes. The outcome of this struggle has important implications for some of the most contentious issues and concerning developments in contemporary politics. Since urban planning is often under local democratic control, local public opinion plays a central role in determining whether cities embrace or reject u",{"id":587,"funder":7,"programme":8,"title":588,"piName":10,"institution":295,"country":100,"year":13,"amount":589,"abstract":590},"cordis-european-research-council-award-101115429","Chemical Transformations in the Inter-Stellar Medium: Photochemical Processes","€1,461,701","Until the beginning of the last century, the scientific convention was that the material in the interstellar medium (ISM) between stars and galaxies was mostly in atomic and ionic form  thus the formation of complex molecules was improbable. Today, however, large complex molecules are being discovered at a dazzling rate  demonstrating the molecular nature of our universe. The physical conditions in the ISM are extremely different than on Earth: in addition to extreme temperatures and low density",{"id":592,"funder":7,"programme":8,"title":593,"piName":10,"institution":594,"country":162,"year":13,"amount":27,"abstract":595},"cordis-european-research-council-award-101040311","Uncovering the mechanisms of action of an antiviral bacterium","UNIWERSYTET JAGIELLONSKI","Animals and microbes interact in intricate ways. Wolbachia, a common intracellular insect symbiont, can manipulate reproduction and protect hosts from viruses. Thus, Wolbachia is an asset in the control of insect-borne diseases. However, as Wolbachia cannot be cultured outside of host cells or genetically manipulated, the mechanisms of its antiviral phenotype remain poorly understood, and this inhibits wider exploitation.I have been working to remedy these deficiencies, and now stand poised to d",{"id":597,"funder":7,"programme":8,"title":598,"piName":10,"institution":599,"country":12,"year":13,"amount":600,"abstract":601},"cordis-european-research-council-award-101040453","REVERT  Regeneration as a Vulnerable State for Microbe-Driven Injury and Tumorigenesis","CHARITE - UNIVERSITAETSMEDIZIN BERLIN","€1,426,714","Tissues with high turnover are hierarchically organized and rely on long-lived stem cells that are protected by a variety of mechanisms. In the gastrointestinal tract, highly active stem cells are located in the base of crypts, where differentiated cells shield them from environmental threats. It has recently emerged that mucosal injuries initiate regenerative repair programs that promote a disruption of cellular hierarchies and reversal of differentiated cells back to the proliferative stem cel",{"id":603,"funder":7,"programme":8,"title":604,"piName":10,"institution":262,"country":100,"year":13,"amount":27,"abstract":605},"cordis-european-research-council-award-101117232","Exploratory Program Synthesis","Our goal is to create Program Synthesis that can be used during Exploratory Programming to boost productivity and reliability when programmers write code. Program synthesis generates code for programmers so they can focus on the problem-solving aspects of their work. This often requires programmers to write a specification for the desired code, but this specification may not exist. Many aspects are initially undecided: implementation details, the division into subtasks, and at times even what th",{"id":607,"funder":7,"programme":8,"title":608,"piName":10,"institution":609,"country":76,"year":13,"amount":610,"abstract":611},"cordis-european-research-council-award-101116482","Transcriptional REGUlation as a mediator of bacterial interactions in the microBIOME","FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPE FELIPE","€1,496,479","Bacteria from the gut microbiota constantly interact with a range of abiotic and biotic factors. Perturbations in these factors, such as nutrient depletion or exposure to exogenous microbes, require specific bacterial responses that involve tightly controlled gene expression changes. However, the transcriptional regulation mechanisms promoting such gene expression changes remain poorly understood despite their importance.REGUBIOME will characterize how responses to specific biotic and abiotic st",{"id":613,"funder":7,"programme":8,"title":614,"piName":10,"institution":615,"country":40,"year":13,"amount":27,"abstract":616},"cordis-european-research-council-award-101042028","Implications of Gender-Affirming Hormone Therapy for Psychosocial Functioning and Social Relationships of Transgender People","STICHTING AMSTERDAM UMC","Transgender health is an area of increasing focus for researchers and medical practitioners across Europe, in part due to rapidly escalating numbers of people identifying as transgender.  A crucial oversight in this area is that very little research has examined how gender-affirming hormone therapy, the most common form of medical intervention for transgender people, shapes psychosocial functioning and ultimately social relationship experiences.  Given the paramount importance of social relation",{"id":618,"funder":7,"programme":8,"title":619,"piName":10,"institution":583,"country":377,"year":13,"amount":620,"abstract":621},"cordis-european-research-council-award-101077722","The genomic adaptations to cope with unpredictable climates over the course of life","€1,497,883","Increasing climatic fluctuations mean that animals need to evolve increased heat resilience whilst simultaneously coping with cold periods throughout their lives. Large animals are particularly susceptible to temperature fluctuations as their large size when mature exposes them to heat stress, and their small size when juvenile exposes them to cold stress. I will test two hypotheses that are central to understanding how large species evolve to cope with temperature fluctuations: 1) Genomic adapt",{"id":623,"funder":7,"programme":8,"title":624,"piName":10,"institution":542,"country":12,"year":13,"amount":625,"abstract":626},"cordis-european-research-council-award-101077037","Learning Isoform Fingerprints to Discover the Molecular Diversity of Life","€1,498,939","Did you know that ~80% of all proteomic data is not utilized? Proteins play a vital role in all biological processes and organisms. We believe that different versions of a single gene product – protein isoforms – shape the molecular diversity of life. However, comprehensive evidence on protein-level is not available. Chromatography-coupled tandem mass spectrometry (LC-MS\u002FMS) is the de-facto standard for measuring proteomes, but it is not good at identifying isoforms because at least 80% of the r",{"id":628,"funder":7,"programme":8,"title":629,"piName":10,"institution":630,"country":26,"year":13,"amount":631,"abstract":632},"cordis-european-research-council-award-101075624","Deciphering female’s SEx hormones - MIcrobiota interactions during a menstrual CYCLE for an efficient personalized medicine in cardiometabolic disorders","CONSIGLIO NAZIONALE DELLE RICERCHE","€1,499,286","Cardiometabolic disorders (CMD), a group of conditions that include cardiovascular diseases, type 2 diabetes and metabolic syndrome, are characterised by dysfunction of glycaemic and\u002For lipid metabolism. Clinical manifestations, severity and progression are different between sexes, the underlying mechanisms of which are largely unknown. The poorer prognosis in women globally calls for an urgent need for better women’s tailored prevention and treatment strategies. Still, for an efficient personal",{"id":634,"funder":7,"programme":8,"title":635,"piName":10,"institution":542,"country":12,"year":13,"amount":636,"abstract":637},"cordis-european-research-council-award-101076915","TOP-down Superlattice engineering of  2D solid-state quantum matter","€1,945,000","Periodic potentials superimposed onto an atomic crystal allow to enhance electronic correlations in a broad class of materials, from semiconductors to semimetals, if the spatial period of the potential becomes comparable to the Fermi wavelength of electrons. In this regime, the external superlattice potential creates tailored electronic minibands with new functionality. By concentrating the density of states into van Hove singularities, superlattices can ultimately lead to flat bands, where comp",{"id":639,"funder":7,"programme":8,"title":640,"piName":10,"institution":542,"country":12,"year":13,"amount":10,"abstract":641},"cordis-european-research-council-award-101076897","The Single-Centre Ambiphile ligand Concept: Cooperative Systems for Waste-free Catalysis","The addition of ammonia to alkenes, which could produce amines in a 100% atom efficient process, has never been achieved by a molecular catalytic system and stands as a modern Holy Grail for the synthetic chemist. Alkyl amines, a major chemical commodity, are typically accessed through stoichiometric methods, even employing toxic N1 feedstocks such as hydrogen cyanide. The fundamental barrier to utilizing ammonia as an N1 feedstock lies in its activation, with a high N-H bond energy and a prefer",{"id":643,"funder":7,"programme":8,"title":644,"piName":10,"institution":542,"country":12,"year":13,"amount":645,"abstract":646},"cordis-european-research-council-award-101078792","Recurring Elements of Modern Facades (1960–1990). Foundations for the Conservation of High-Tech Modernism.","€1,499,919","High-Tech architecture made use of standardized, serial components whose characteristics were meticulously described in technical specifications. The scope of this historic information is almost unmanageable, the analogue sources are increasingly difficult to access. The challenge of quantity is mirrored by the scale of the built structures, constraining the possibilities of thorough building investigation. As a result, these building elements are often replaced during renovation before they cou",{"id":648,"funder":7,"programme":8,"title":649,"piName":10,"institution":542,"country":12,"year":13,"amount":650,"abstract":651},"cordis-european-research-council-award-101076858","Understanding Dynamic Processes at Nanoscale Working Interfaces for Solar Energy Conversion","€1,988,500","To slow down global warming and to overcome the reliance on fossil fuels, a transition to a carbon neutral society fueled by renewable energy sources will be crucial. Therefore, the conversion of solar energy to storable, energy-dense fuels will be an important step to satisfy the need for clean and reliable power. Economically viable systems for solar-to-chemical conversion often base on thin film photoelectrodes with highly complex internal architectures. The combination of different length sc",{"id":653,"funder":7,"programme":8,"title":654,"piName":10,"institution":542,"country":12,"year":13,"amount":655,"abstract":656},"cordis-european-research-council-award-101077577","A Decentralized Operating System","€1,491,838","The DOS project targets the challenge of developing and deploying distributed applications on large-scale decentralized computing infrastructures (DCIs) such that their dependability properties, e.g., safety and security, can be enforced by the foundational layers of the system stack in a policy-compliant manner.While it is possible today to construct distributed applications, it is challenging to ensure that their dependability properties are preserved end-to-end in a DCI consisting of a divers",{"id":658,"funder":7,"programme":8,"title":659,"piName":10,"institution":443,"country":377,"year":13,"amount":27,"abstract":660},"cordis-european-research-council-award-101040641","FROM SINGLE MOLECULES TO CELL REPROGRAMMING: DECIPHERING AND RECODING DISORDERED PIONEER TRANSCRIPTION  FACTORS","Pioneer transcription factors (pTFs) have unique capabilities beyond classical TFs: They can invade and open closed chromatin, initiating cell-fate changes. Their remarkable abilities have been used to steer cell-fate decisions and to induce a pluripotent stem cell state through poorly understood pathways. Like most TFs, pTFs consist of structured DNA-binding domains (DBDs) flanked by long intrinsically disordered regions (IDRs). In attempts to explain their pioneering functions, intense focus h",{"id":662,"funder":7,"programme":8,"title":663,"piName":10,"institution":664,"country":40,"year":13,"amount":665,"abstract":666},"cordis-european-research-council-award-101078533","Improving Digital Mental Health Interventions: ENGAGEment as Mechanism of Impact","UNIVERSITEIT TWENTE","€1,499,590","Millions of people struggle with mental health issues, such as depression and anxiety. Effective treatments exist but are not within reach of everyone due to limited resources. Digital Mental Health Interventions (DMHIs), in which treatments are delivered by using technology via the Internet and apps, can be a solution. However, high rates of drop-out and large individual differences in outcomes make them not yet an adequate solution. Due to scarce process research, with  a largely mono-discipli",{"id":668,"funder":7,"programme":8,"title":669,"piName":10,"institution":354,"country":40,"year":13,"amount":27,"abstract":670},"cordis-european-research-council-award-101077812","Low oxygen, key ingredient of the plant stem cell niche?","Oxygen (O2) is essential for efficient energy conversion by multicellular organisms, including plants. Therefore, environmental conditions where O2 is limited (hypoxia) such as during flooding stress, pose a severe threat to plant survival and can lead to death when prolonged. I recently discovered that plant stem cells of the shoot apical meristem (SAM) are embedded in a local hypoxic niche and that this condition is even important for meristem activity. This suggests that local hypoxia may pla",{"id":672,"funder":7,"programme":8,"title":673,"piName":10,"institution":168,"country":169,"year":13,"amount":27,"abstract":674},"cordis-european-research-council-award-101076231","A New Perspective on City Logistics: Concepts, Theory, and Models for Designing and Managing Logistics as a Service","Several social, economic, and technological trends are coming together to revolutionize the way people, products, and services are brought together. Goods are gaining more mobility with drastic implications for cities. The current city logistics (CL) paradigm, which does not consider the mobility of goods a public need, limits our capacity to understand and respond to the challenges and opportunities brought by this profound change. Taking a different perspective, GoodMobility proposes to replac",{"id":676,"funder":7,"programme":8,"title":677,"piName":10,"institution":678,"country":33,"year":13,"amount":27,"abstract":679},"cordis-european-research-council-award-101077048","Uncovering the role and regulation of 3D DNA-RNA nuclear dynamics in controlling cell fate decisions","INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH","At the onset of mammalian life, the first lineage specification decision is made where embryonic cells opt tobecome either part of the placenta or the future body. Proper regulation of this choice is crucial for subsequentdevelopment. However, we dont know how the transcription program and 3D genome architecture arise,interconnect, and are controlled to determine the fate of each cell in a developing embryo. Recent studies,including my work, suggest that in addition to canonical mRNA-coding gene",{"id":681,"funder":7,"programme":8,"title":682,"piName":10,"institution":683,"country":162,"year":13,"amount":684,"abstract":685},"cordis-european-research-council-award-101077420","Devising Reliable Electronic Structure Schemes through Eclectic Design","UNIWERSYTET MIKOLAJA KOPERNIKA","€1,218,088","Modern quantum chemistry reached a remarkable level of description of atoms and molecules and their interactions. Theoretical approaches are particularly helpful when experimental studies are hampered or slowed down due to a trial-and-error approach. In such cases, computational chemistry can provide the much sought-after understanding of molecular properties and reactivity. Unfortunately, conventional wave function models are too expensive for large-scale modeling or require user control on an ",{"id":687,"funder":7,"programme":8,"title":688,"piName":10,"institution":689,"country":76,"year":13,"amount":690,"abstract":691},"cordis-european-research-council-award-101076533","Extreme time and angular resolution in the optical  with Cherenkov telescopes","CENTRO DE INVESTIGACIONES ENERGETICAS MEDIOAMBIENTALES Y TECNOLOGICAS","€2,473,531","The universe in the visible wavelength remains largely unexplored in the sub-second time regime and sub-milliarcsecond scale, primarily due to instrumental limitations. Overcoming these impediments would bring a breakthrough in our knowledge of stellar physics, evolution and modelling by imaging the stars and their surroundings as well as unravel the history of the Solar System.MicroStars will demonstrate the viability of a cost-effective and novel solution to enhance the capabilities of Imaging",{"id":693,"funder":7,"programme":8,"title":694,"piName":10,"institution":389,"country":12,"year":13,"amount":516,"abstract":695},"cordis-european-research-council-award-101077853","Defusing mini-chromosomes—the Achilles’ heel of the wheat blast pandemic","PANDEMIC is an ambitious high-risk\u002Fhigh-gain program to deliver an innovative pathogen-guided strategy for crop disease resistance. The wheat blast pandemic is a clear and present danger to global food security. It is caused by the blast fungus, Magnaporthe oryzae, which, after emerging in Brazil only ~35 years ago, has spread over the last 5 years to Southeast Asia and Africa. We discovered that all isolates of the pandemic wheat blast fungus belong to a single, asexual clonal lineage. These pa",{"id":697,"funder":7,"programme":8,"title":698,"piName":10,"institution":699,"country":700,"year":13,"amount":27,"abstract":701},"cordis-european-research-council-award-101077374","Decoding mitochondrial selective autophagy in synaptic homeostasis during ageing","ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON","EL","Age-dependent accumulation of damaged mitochondria and synaptic loss represent early pathological hallmarks of brain ageing leading to neuronal death. Mitochondria-selective autophagy (mitophagy) is triggered to eliminate defective organelles promoting cellular and organismal survival. Mitophagy declines with age, while its induction extends lifespan and confers neuroprotection across diverse species. Although the pivotal role of mitophagy in neuronal physiology is steadily emerging, its contrib",{"id":703,"funder":7,"programme":8,"title":704,"piName":10,"institution":437,"country":57,"year":13,"amount":705,"abstract":706},"cordis-european-research-council-award-101077939","Consequences of warming-driven vegetation change for Arctic carbon cycling and feedbacks to the global climate system","€1,499,264","ArcticEDGE will identify the consequences of warming-driven vegetation change for the functioning of Arctic ecosystems, particularly the cycling of carbon, and the impact on the global climate. The Arctic is the fastest-warming region on Earth, and Arctic soils contain more than double the amount of carbon currently in the atmosphere. Changes in the vegetation can influence whether this carbon is released into the atmosphere, thus contributing to additional climate warming, or stored in soils an",{"id":708,"funder":7,"programme":8,"title":709,"piName":10,"institution":710,"country":40,"year":13,"amount":27,"abstract":711},"cordis-european-research-council-award-101076991","The Body Positioning System: A GPS for somatosensory space","STICHTING RADBOUD UNIVERSITEIT","Reaching to an object touching the body is so commonplace that we hardly give it a second thought. However, this simple behavior is actually an incredibly complicated problem the brain must solve on a daily basis. Somatosensory information is initially represented in neural maps whose relationship with the physical body is ambiguous. Despite this, the brain can accurately pinpoint where the object is in three-dimensional space and move the reaching hand towards it. How remains a mystery, though ",{"id":713,"funder":7,"programme":8,"title":714,"piName":10,"institution":715,"country":716,"year":13,"amount":717,"abstract":718},"cordis-european-research-council-award-101076311","The role of Base molecules in AErosol formation","THE CYPRUS INSTITUTE","CY","€2,248,644","Aerosol formation and growth mechanisms need to be better understood to improve air quality and weather prediction models, and reduce uncertainty of radiative forcing in climate change projections. Globally, half of the aerosol population is formed via gas-to-particle conversion and the fraction exceeds 90% in high latitudes. In many locations, the initial molecular cluster forms from sulphuric acid and ammonia or dimethylamine. Growth to an aerosol particle is often explained by the condensatio",{"id":720,"funder":7,"programme":8,"title":721,"piName":10,"institution":722,"country":26,"year":13,"amount":499,"abstract":723},"cordis-european-research-council-award-101077917","Quantum Optical MUltidimensional NEtworks","UNIVERSITA DEGLI STUDI DI FIRENZE","Quantum Internet will allow unprecedented applications that will dramatically change our lives, spanning from quantum secured communications to distributed quantum simulations, i.e., ultra-precise clock synchronisation, quantum secured identification, efficient distribution of data and energy, quantum sensors and secure access to quantum devices in the cloud. The main technical limitations currently restricting the range of applicability of the quantum internet are the intrinsic rate-distance li",{"id":725,"funder":7,"programme":8,"title":726,"piName":10,"institution":366,"country":12,"year":13,"amount":727,"abstract":728},"cordis-european-research-council-award-101077963","High-pressure nitride materials: towards the controllable and scalable synthesis in a diamond anvil cell","€1,878,908","Over the past decade a branch of solid-state inorganic chemistry has emerged that aims the discovery of novel atypical compounds at high-pressure conditions. Nevertheless, the need of modern technology in new materials, which are available only from the high-pressure synthesis, can be fulfilled only if these materials are produced in measurable quantities via a controlled and reproducible process. Within HIPMAT I will focus on the synthesis of nitride materials  a class of compounds with outstan",{"id":730,"funder":7,"programme":8,"title":731,"piName":10,"institution":732,"country":313,"year":13,"amount":733,"abstract":734},"cordis-european-research-council-award-101076968","Sensitive periods for audition: Teenagers with Normal Hearing & Hearing Loss","UNIVERSITE LIBRE DE BRUXELLES","€1,476,432","Orienting oneself in a crowded playground, understanding the teacher’s explanation despite the surrounding chatter, lip-reading to support auditory perception in noisy backgrounds: these are all complex but essential skills for navigating lively schools. In children with normal hearing, the auditory system is functionally mature by 6 months of age. Yet complex auditory processing remains immature until mid to late adolescence. Strikingly, adolescence is characterized by the onset of puberty, whi",{"id":736,"funder":7,"programme":8,"title":737,"piName":10,"institution":312,"country":313,"year":13,"amount":738,"abstract":739},"cordis-european-research-council-award-101078225","Soft optoelectronics and ion-based circuits for diagnostics and closed-loop neuromodulation of the auditory pathway","€1,499,213","Understanding and modulating neural networks requires high-resolution acquisition of neural activity over time, real-time analysis, and minimally invasive stimulation methods with high specificity. Such procedures are particularly needed for treatment of sensory disfunction (e.g. hearing loss), and certain neurological diseases (e.g. epilepsy). The lack of soft, biocompatible, hybrid and smart neural interfaces hinders our capacity to study complex neural dynamics and efficiently apply responsiv",{"id":741,"funder":7,"programme":8,"title":742,"piName":10,"institution":743,"country":744,"year":13,"amount":27,"abstract":745},"cordis-european-research-council-award-101076866","Mosquito-virus matchmaking: Elucidating the biological basis of compatibility  between viruses and mosquitoes","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","FR","Half of the worlds population is at risk for mosquito-borne diseases. Yet, less than 3% of the mosquito species on earth can transmit pathogens to humans. Even within a species that specializes in biting humans and is the major vector for dengue virus (Aedes aegypti), mosquito populations on the globe transmit DENV with a wide range of efficiencies. Thus, some virus-mosquito pairs match with each other, and enable viral transmission, while others dont. Understanding the biological processes that",{"id":747,"funder":7,"programme":8,"title":748,"piName":10,"institution":168,"country":169,"year":13,"amount":749,"abstract":750},"cordis-european-research-council-award-101078097","Spatiotemporal regulation of centriolar satellite homeostasis","€1,588,710","Membrane-less compartmentalization has emerged as a powerful, yet mysterious, process for the spatiotemporal control of fundamental cellular processes. How the identity of a membrane-less organelle is established, maintained, and dynamically altered remains unclear. In this project, I will investigate the fascinating biology of the centriolar satellites (hereafter CS), a vertebrate-specific membrane-less organelle. CS was first discovered as granules that cluster and move around centrosomes – ma",{"id":752,"funder":7,"programme":8,"title":753,"piName":10,"institution":754,"country":26,"year":13,"amount":755,"abstract":756},"cordis-european-research-council-award-101075903","Acoustic fLow InteractioN over sound absorbing surfaces: effects on ImpedaNce and draG","POLITECNICO DI TORINO","€1,499,069","The lack of fundamental knowledge of the interaction between an acoustic wave and a turbulent boundary layer grazing an acoustically treated surface, such as an acoustic liner, is the cause of unexpected and unphysical results found when performing the acoustic characterization of the sound absorbing surface with inverse eduction methods. This is because, in this field, acoustic and aerodynamic have never been fully coupled.To fill this knowledge gap, the acoustic and hydrodynamic velocities nea",{"id":758,"funder":7,"programme":8,"title":759,"piName":10,"institution":760,"country":100,"year":13,"amount":761,"abstract":762},"cordis-european-research-council-award-101077921","Beyond mapping of the human brain: causal deconstruction of brain mechanisms underlying complex social behaviors","WEIZMANN INSTITUTE OF SCIENCE","€1,637,981","Social information pervades every aspect of our lives, and our ability to process it and respond appropriately is essential to our success as individuals and of society as a whole. Despite its critical importance, there are profound individual differences in social processing abilities. The key to understanding this variance may lie beyond isolated cortical regions, in the poorly understood large-scale interactions between different cortical networks which facilitate the integration of informati",{"id":764,"funder":7,"programme":8,"title":765,"piName":10,"institution":766,"country":33,"year":13,"amount":767,"abstract":768},"cordis-european-research-council-award-101078132","Energy Transitions and the Rise and Fall of Great Financial Centers","WIRTSCHAFTSUNIVERSITAT WIEN","€1,499,749","For all their differences, modern nation-states are both the energy transition leaders and financial leaders of their time. They are also home to our great financial centers (GFCs), and the question of the rise and fall of GFCs is a matter of longstanding debate. Existing explanations struggle to explain the timing and forecasting of the rise and fall of GFCs in a systematic manner. No researcher has connected the dots between energy transitions, financial transitions, the role of financial syst",{"id":770,"funder":7,"programme":8,"title":771,"piName":10,"institution":772,"country":461,"year":13,"amount":773,"abstract":774},"cordis-european-research-council-award-101077353","Geographies of dynamic governance assemblages in development cooperation civil society spaces","THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN","€1,499,745","Interacting socio-political, economic, and environmental crises are destabilizing efforts to attain the global vision entailed in UN Agenda 2030. The need for adaptive and inclusive development cooperation governance has never been stronger. As complex needs accelerate due to the coronavirus pandemic, rapidly changing climates, and increasing levels of conflict and human insecurity, trust and legitimacy in traditional institutions and actors is weak and declining. In efforts to achieve greater d",{"id":776,"funder":7,"programme":8,"title":777,"piName":10,"institution":778,"country":162,"year":13,"amount":779,"abstract":780},"cordis-european-research-council-award-101077099","The spatial organization of gene regulation in embryonic development.","INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK","€1,955,000","Master transcription factors (TFs) cooperate with chromatin in regulating genomic activity in animal development and stress response. Local clustering of TFs into dense, sub-micrometer size condensates is emerging as a key feature of transcriptional regulation. This includes intranuclear condensates formed by pioneer TFs during development, transient clusters of RNA Polymerase II complex and nuclear stress bodies formed during a heat shock. Despite the ubiquity of these assemblies, we know littl",{"id":782,"funder":7,"programme":8,"title":783,"piName":10,"institution":784,"country":12,"year":13,"amount":785,"abstract":786},"cordis-european-research-council-award-101078689","Multidimensional interferometric photoelectron spectroscopy with extreme ultraviolet photons","ALBERT-LUDWIGS-UNIVERSITAET FREIBURG","€1,577,500","Photochemical reactions are the central driving force in nature and in sustainable technologies. Understand-ing photochemical reactions on the quantum level is thus a primary goal in science. However, this task re-mains a major experimental and theoretical challenge even on the single-molecule level due to the involved ultrafast time scales, predominantly nonradiative processes and strongly coupled degrees of freedom. Methods are needed that provide a gap-less view on the molecular mechanisms wi",{"id":788,"funder":7,"programme":8,"title":789,"piName":10,"institution":790,"country":33,"year":13,"amount":791,"abstract":792},"cordis-european-research-council-award-101076260","A molecular atlas of Actin filament IDentities in the cell motility machinery","INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA","€1,499,531","The actin cytoskeleton is essential to cellular function and hence to life. It is regulated not only via a complex synergistic and competitive interplay between actin-binding proteins (ABP), but also by filament biochemistry and filament geometry. Both the biochemical identity of an actin filament as well as the geometrical identity of actin networks are defined by ABP activity, while biochemistry and geometry also regulate ABP recruitment. However, it is still unknown how actin filament biochem",{"id":794,"funder":7,"programme":8,"title":795,"piName":10,"institution":376,"country":377,"year":13,"amount":796,"abstract":797},"cordis-european-research-council-award-101076437","Tunable Nanoengineered Transition Metal Dichalcogenides for Quantum Nanophotonics","€1,499,578","In optical quantum computing, qubits are encoded on single indistinguishable photons emitted by single-photon sources (SPSs). The computation is carried out by interfering single photons and by measuring the output using single-photon detectors. A scalable optical quantum computer requires many individual SPSs emitting indistinguishable single photons, however, different SPSs emit light at slightly different wavelengths due to fabrication imperfections. This issue can be resolved by implementing",{"id":799,"funder":7,"programme":8,"title":800,"piName":10,"institution":801,"country":162,"year":13,"amount":802,"abstract":803},"cordis-european-research-council-award-101076570","Proportional Algorithms for Democratic Decisions","UNIWERSYTET WARSZAWSKI","€1,479,938","The project is set in the field of computational social choice. We will focus on formal models describing scenarios, where a group of individuals, called voters, disagrees on certain matters, yet needs to make a collective decision. The decision must truly represents a compromise. We focus on group fairness understood as proportionality.  There are numerous real-life scenarios that involve collective (public) decisions, and where our solutions could be applied. Examples include: elections of rep",{"id":805,"funder":7,"programme":8,"title":806,"piName":10,"institution":389,"country":12,"year":13,"amount":807,"abstract":808},"cordis-european-research-council-award-101075357","Glycan foldamers: designing oligosaccharides to build three-dimensional architectures","€1,499,956","Natural biopolymers have inspired the development of synthetic analogues – i.e. foldamers – capable of adopting defined conformations and forming programmable three-dimensional architectures. These compounds are mainly based on peptides and nucleic acids, that are well understood at the molecular level. The diversity, intrinsic chirality, and ability to generate hierarchical assemblies suggest that carbohydrates hold an even larger potential for the generation of three-dimensional structures. Ho",{"id":810,"funder":7,"programme":8,"title":811,"piName":10,"institution":389,"country":12,"year":13,"amount":812,"abstract":813},"cordis-european-research-council-award-101075962","Circuit Quantum Electrodynamic Spectroscope: a new superconducting microwave quantum sensor","€1,480,000","Superconductivity is a remarkable phase of matter which has advanced a wide variety of fields, including particle accelerators, biomedical imaging tools, and quantum computers. However, there are fundamental open questions about the nature of the superconducting state in many materials, with new ones being discovered every year. Understanding their structure can help unravel the dynamics of interacting many-body quantum systems, and lead to a next generation of technological innovations.Supercon",{"id":815,"funder":7,"programme":8,"title":816,"piName":10,"institution":515,"country":40,"year":13,"amount":27,"abstract":817},"cordis-european-research-council-award-101075934","Reconstructing enzymes for novel nitrogen-nitrogen bond forming chemistry","Nitrogen-nitrogen (N-N) bonds have fascinating structural and functional properties, are ubiquitously found in diverse pharmaceuticals and fine chemicals, and represent important key structural motifs in diverse natural products, endowing them with potent biological activities. However, traditional chemical procedures to synthesize N-N bond-containing compounds are often difficult to realize, costly and environmentally unfriendly. In addition, the formation of intermolecular N-N linkages is part",{"id":819,"funder":7,"programme":8,"title":820,"piName":10,"institution":344,"country":57,"year":13,"amount":821,"abstract":822},"cordis-european-research-council-award-101078349","DOING THE IMPOSSIBLE - adaptive behaviour in migratory birds to overcome physiological and environmental constraints","€1,499,921","Advances in tracking technology during the last decade have shown that migratory birds have the capacity to fly longer and faster than we previously thought was possible. Yet, we do not know how birds perform these seemingly impossible travels as it previously only was possible to record spatiotemporal patterns. The overall aim of this project is to reveal constraints and the behavioural and physiological adaptations that has evolved to overcome them, thus making the extreme performances of migr",{"id":824,"funder":7,"programme":8,"title":825,"piName":10,"institution":472,"country":125,"year":13,"amount":826,"abstract":827},"cordis-european-research-council-award-101076986","Unraveling the etiology of congenital heart defects – The role of maternal genetics and cardiovascular disease as a risk factor","€1,495,845","One in a hundred infants is born with a congenital heart defect (CHD). Both genetic and environmental risk factors, such as maternal diabetes and obesity, are known to cause CHD, however, little is known about the disease mechanisms behind these risks. CHD can occur as an element of a syndrome, in conjunction with other anomalies, or as an isolated defect. I propose that there is an etiologically distinct environmental CHD subgroup, where in addition to the childs genes, maternal genetics and ge",{"id":829,"funder":7,"programme":8,"title":830,"piName":10,"institution":75,"country":76,"year":13,"amount":27,"abstract":831},"cordis-european-research-council-award-101076680","Engineering of Photo-rechargeable Nanoswimmers using Multicomponent Heterojunctions","The realization of smart nanoswimmers capable of moving and performing desired tasks in an aqueous environment is a technological challenge due to the viscous and thermal forces exerted upon them. While various types of external stimulus can be used to activate their autonomous motion, light is the easiest to operate and most flexible, due to the opportunities that it offers for motion modulation through intensity, wavelength, and direction. However, such optical control is affected by the prope",{"id":833,"funder":7,"programme":8,"title":834,"piName":10,"institution":422,"country":40,"year":13,"amount":835,"abstract":836},"cordis-european-research-council-award-101077879","Revolutionizing AI in drug discovery via innovative molecular representation paradigms","€1,494,006","Artificial intelligence (AI) in the form of deep learning is driving unprecedented progress in numerous fields, e.g., for protein structure prediction and organic reaction planning. In drug discovery and chemical biology, such progress is an “evolution” rather than a revolution: several tasks still await to be solved by AI, e.g., accurate structure-activity and activity-cliff prediction, and design of structurally innovative chemical matter. Increasingly complex deep learning approaches are lead",{"id":838,"funder":7,"programme":8,"title":839,"piName":10,"institution":175,"country":33,"year":13,"amount":840,"abstract":841},"cordis-european-research-council-award-101075661","The History of Feminist Political Thought and Women’s Rights Discourses in East Central Europe 1929 - 2001","€1,494,129","This project will produce the first comprehensive and multi-disciplinary history of feminist political thought and women’s rights discourses in East Central Europe in a broad chronological perspective. The project builds on a solid base of existing scholarship, but does more than weave the stories of individual women or fragmented national case studies in the existing scholarship into a coherent narrative. Instead, it reinterprets the story of feminism in the region in relation to state socialis",{"id":843,"funder":7,"programme":8,"title":844,"piName":10,"institution":845,"country":40,"year":13,"amount":846,"abstract":847},"cordis-european-research-council-award-101076054","Generalisation into sentence and predicate positions","UNIVERSITEIT VAN AMSTERDAM","€1,493,715","Generalisations are fundamental to every scientific discipline: Every cell has a plasma membrane, Every electron has a negative charge, Every natural number has a unique successor. By means of generalisation we turn a statement about a particular individual into a statement about a class of entities. Generalisations are essential to valid deductive reasoning. They are the building blocks of virtually every scientific theory, and therefore essential to understanding, explaining, and making predic",{"id":849,"funder":7,"programme":8,"title":850,"piName":10,"institution":851,"country":26,"year":13,"amount":852,"abstract":853},"cordis-european-research-council-award-101077758","Transitions in Rubble-pile Asteroid Chaotic Environment and granular Structures","POLITECNICO DI MILANO","€1,499,750","We are now living exciting times for asteroid exploration. The increasing availability of in-situ observation data, providing unprecedented level of detail, makes the study of asteroids an exciting and living frontier. Asteroids are rubble piles, i.e., gravitational aggregates of loosely consolidated material. However, no direct measurements of asteroids interior exist and little is known about the mechanisms governing their formation and evolution. Not only limited by a lack of data, the unders",{"id":855,"funder":7,"programme":8,"title":856,"piName":10,"institution":857,"country":33,"year":13,"amount":858,"abstract":859},"cordis-european-research-council-award-101076409","Foundations for Sustainable Security","TECHNISCHE UNIVERSITAET GRAZ","€1,498,489","Security and efficiency are often seen as a conflict. IT already consumes 11% of electricity globally, with a steep upwards trend. Resource sharing increases efficiency but introduces information leakage vulnerabilities, such as Meltdown and Spectre. Reducing reliability margins also increases efficiency but introduces fault attacks, such as Rowhammer and Plundervolt. This reveals a fundamental problem in current systems: Reliability mechanisms are not designed with adversaries in mind. Security",{"id":861,"funder":7,"programme":8,"title":862,"piName":10,"institution":405,"country":40,"year":13,"amount":863,"abstract":864},"cordis-european-research-council-award-101075118","Understanding respiratory tract infections through minimally-invasive, daily nasal sampling in children","€1,677,858","Pneumonia is the number one infectious cause of death in children worldwide. Many of the viruses and bacteria that cause pneumonia regularly infect, or colonize, the upper respiratory tract (URT) without causing disease. This drives community transmission but is also an important source of immunity. The processes and key host immune and microbiota factors that determine the infection kinetics, transmission and development of immunity during such infections need elucidation. I have recently optim",{"id":866,"funder":7,"programme":8,"title":867,"piName":10,"institution":19,"country":12,"year":13,"amount":868,"abstract":869},"cordis-european-research-council-award-101078722","Decoding Requirements for Infiltration of T ceLLs into solid tumors","€1,521,000","Cancer immunotherapies that leverage T cell activities are transforming cancer treatment. Currently, enormous effort has been devoted to empowering T cells to recognize and attack tumor cells. In contrast, the trafficking of T cells into tumors, a crucial prerequisite and limiting factor for effective T celltumor cell interactions, receives relatively less attention while at the same time being poorly understood. This is due to the complex and dynamic nature of T cell trafficking and the lack of",{"id":871,"funder":7,"programme":8,"title":872,"piName":10,"institution":772,"country":461,"year":13,"amount":873,"abstract":874},"cordis-european-research-council-award-101077471","Corporate Moral Progress","€1,371,715","Within business ethics, there is a longstanding debate concerning Corporate Moral Responsibility, the question of whether corporations themselves are the kinds of things that can be responsible for wrongdoing. Proponents of this view hope to vindicate our sense that firms are the appropriate targets of blame and censure. However, proponents have failed to decisively make their case, and they have also failed to come to terms with the magnitude of corporate wrongdoing. Even if firms are possibly ",{"id":876,"funder":7,"programme":8,"title":877,"piName":10,"institution":295,"country":100,"year":13,"amount":878,"abstract":879},"cordis-european-research-council-award-101077050","Unjust Enrichment and Public Policy","€1,159,231","The basic maxim of the law of unjust enrichment states that a person should not be unjustly enriched at anothers expense. This broad principle is currently primarily used to solve local problems and disputes between specific individuals through private litigation. The proposed project offers a paradigm shift and the use of the fundamental principle prohibiting unjust enrichment to solve broad societal issues, both as a private and a public law doctrine. This is a double paradigm shift. From the ",{"id":881,"funder":7,"programme":8,"title":882,"piName":10,"institution":883,"country":12,"year":13,"amount":27,"abstract":884},"cordis-european-research-council-award-101077083","Counting (with) homomorphisms","UNIVERSITAET REGENSBURG","This project addresses the computational complexity of counting problems in graphs; such problems ask to compute the number of certain structures rather than merely deciding their existence. Counting problems find applications in diverse areas like network analysis, machine learning, probabilistic databases, and statistical physics. They are linked to fundamental questions in complexity theory and give rise to algorithmic breakthroughs for decision problems.The proposed project will go beyond th",{"id":886,"funder":7,"programme":8,"title":887,"piName":10,"institution":312,"country":313,"year":13,"amount":888,"abstract":889},"cordis-european-research-council-award-101075690","The Disobedient Brain: The social neuroscience of non-compliance to immoral orders","€1,496,688","The core goal of this project is to unravel the mechanisms of disobedience. To understand the factors that prevent an individual from complying with immoral orders, research should focus on two critical axes: (1) which social and situational factors support disobedience and (2) which individual traits and neuro-cognitive processes support disobedience. While the first axe has been extensively addressed in past literature, the second axe has scarcely been approached. DISOBEY is uniquely focused o",{"id":891,"funder":7,"programme":8,"title":892,"piName":10,"institution":893,"country":12,"year":13,"amount":894,"abstract":895},"cordis-european-research-council-award-101076560","Flux Race Investigation for Dissection Of Metabolic-bottlenecks: Leveraging the tremendous potential of algal metabolic diversity","RHEINLAND-PFALZISCHE TECHNISCHE UNIVERSITAT","€1,937,500","A ~70% increase in food production is required to feed the world population by 2050, putting increased productivity on a collision course with environmental and sustainability goals. Aiming to meet this growing demand, photosynthesis-related pathways are regarded as a promising target for crop improvement to increase agricultural yield, however, they remain mostly unexploited. Furthermore, while empirical studies have shown that photosynthetic efficiency is higher in microalgae than in both C3 o",{"id":897,"funder":7,"programme":8,"title":898,"piName":10,"institution":899,"country":12,"year":13,"amount":900,"abstract":901},"cordis-european-research-council-award-101076671","Chromatin 3D architecture in Archaea","EUROPEAN MOLECULAR BIOLOGY LABORATORY","€1,494,500","This proposal brings together the field of chromatin evolution and state-of-the-art structural biology to advance our understanding of a fundamental question: origin of chromatin structural and regulatory complexity.Eukaryotes and most groups of archaea organize their genomes in the form of histone-based chromatin. Conservation of histones across the tree of life goes beyond protein sequence and histone fold. Tertiary arrangement of histones and DNA geometry in archaeal nucleosomes resemble thos",{"id":903,"funder":7,"programme":8,"title":904,"piName":10,"institution":905,"country":76,"year":13,"amount":906,"abstract":907},"cordis-european-research-council-award-101077809","Constraints and Opportunities for Horizontal Gene Transfer in Bacterial Evolution","SERVICIO MADRILENO DE SALUD","€1,497,613","Horizontal gene transfer (HGT) –the movement of genetic material between individuals– is a significant force fueling bacterial evolution. Through HGT, bacteria acquire new traits, develop new metabolic capabilities and learn to withstand harsh environmental conditions. However, in some cases, HGT brings genetic information that is not advantageous to its host. Despite its crucial relevance for bacterial ecology and evolution, understanding the selective forces that drive the success (or failure)",{"id":909,"funder":7,"programme":8,"title":910,"piName":10,"institution":312,"country":313,"year":13,"amount":911,"abstract":912},"cordis-european-research-council-award-101075873","Pulsed Laser Light and Nano-encapsulated Ocular Dyes for Advanced Therapies in the Eye","€1,499,351","Ocular diseases affect the quality of life of millions of patients. Despite improvements in pharmacological treatments, the arsenal of medications to treat severe ocular diseases today remains rather restricted to traditional drugs. Use of most modern biotherapeutics like proteins and nucleic acids, could be a major step forward. However, current ways of administration such as eye drops and intravitreal injections, are no longer sufficient to deliver these drugs to most targets in the eye. There",{"id":914,"funder":7,"programme":8,"title":915,"piName":10,"institution":94,"country":12,"year":13,"amount":916,"abstract":917},"cordis-european-research-council-award-101076793","A physics-based study of ice stream dynamics","€1,826,073","Ice streams are river-like corridors of fast flowing ice that account for the vast majority of ice discharge to the ocean in continental ice sheets. Their most outstanding feature is that they can appear spontaneously within a slowly moving ice sheet, self-organize in evenly spaced patterns, and switch on and off over time. Yet, a full explanation of ice stream formation and evolution is one of the longest standing open problems in glaciology. This knowledge gap has precluded fundamental investi",{"id":919,"funder":7,"programme":8,"title":920,"piName":10,"institution":443,"country":377,"year":13,"amount":921,"abstract":922},"cordis-european-research-council-award-101077592","Spatiotemporal Analytical Modelling for Paleobiology","€1,498,735","Radical changes in the Earth’s biome as a consequence of climate change will fundamentally affect human society and its relation to the natural world.  How can we best model species dynamics, to make predictions for the future? What are the main drivers underlying these dynamics, and how are these changing as we enter the Anthropocene? A great compass for biotic changes we will see in coming decades is the study of changes the Earth has experienced before – from alterations in the distribution o",{"id":924,"funder":7,"programme":8,"title":925,"piName":10,"institution":88,"country":89,"year":13,"amount":27,"abstract":926},"cordis-european-research-council-award-101076687","3D diamond growth","Diamond, due its outstanding properties, is a desired material to coat various objects for medical, bioelectronics, optical, aerospace, marine and other applications. However, achieving uniform coatings on complex-shaped 3D objects is still a not overcome challenge due to 2D nature of current deposition techniques. The aim of this project is to develop a new diamond growth technology, which will allow diamond synthesis in 3D and accelerate the widespread use of diamond-based materials in new res",{"id":928,"funder":7,"programme":8,"title":929,"piName":10,"institution":930,"country":744,"year":13,"amount":931,"abstract":932},"cordis-european-research-council-award-101076351","Smart Cardiac Magnetic Resonance Delivering One-Click and Comprehensive Assessment of Cardiovascular Diseases","UNIVERSITE DE BORDEAUX","€1,498,529","Cardiovascular disease (CVD) causes at least 1.8 million European deaths annually, exceeding fatalities from cancer, chronic respiratory disease, and diabetes. Consequently, the fight against CVD has become the main priority of the World Health Organization.In the pursuit of understanding and treating CVD, cardiac magnetic resonance imaging (CMR) has remained the only modality capable of providing a comprehensive assessment of the hearts function and structure without harmful radiation. Unfortun",{"id":934,"funder":7,"programme":8,"title":935,"piName":10,"institution":295,"country":100,"year":13,"amount":107,"abstract":936},"cordis-european-research-council-award-101078727","Is the Presence of Technology Improving Corporations and Increasing the Prosperity of Investors and Individuals?","The use and importance of advanced technologies is continuously increasing in the corporate world.  Technology is changing how investors interact with companies, how investors analyze and interpret the information provided by companies, and even the standard design of compensation in corporations. The goal of this study is to understand whether and how the increasing presence of technology is improving corporations and contributing to the wealth and prosperity of individuals\u002F investors, and when",{"id":938,"funder":7,"programme":8,"title":939,"piName":10,"institution":940,"country":12,"year":13,"amount":941,"abstract":942},"cordis-european-research-council-award-101075541","Neural basis of zebrafish collective decision-making","UNIVERSITAT KONSTANZ","€1,498,787","It is challenging for isolated animals to reliably extract and integrate behaviorally relevant information from the natural environment. Due to the limited sensory capacity of individuals, many animal species therefore share and evaluate cues collectively, allowing them to solve complex decision-making tasks as a group. The behavioral algorithms and neural mechanisms that give rise to these cognitive abilities remain poorly understood. In many fish species, these behaviors are largely vision-bas",{"id":944,"funder":7,"programme":8,"title":945,"piName":10,"institution":946,"country":40,"year":13,"amount":10,"abstract":947},"cordis-european-research-council-award-101076891","Emotional skills: The role of emotional intelligence for strategic interactions and markets","TILBURG UNIVERSITY- UNIVERSITEIT VAN TILBURG","Emotional intelligence, like anticipating the emotions of others and regulating ones own emotions, is thought to be a crucial skill to do well in the workplace. This may be especially true for strategic interactions relevant for the workplace such as cooperation, bargaining, and market interactions. From experimental studies, we know that emotions play an important role in these interactions. Yet, whether or how emotional skills influence strategic interactions is unknown. Economists and other s",{"id":949,"funder":7,"programme":8,"title":950,"piName":10,"institution":389,"country":12,"year":13,"amount":10,"abstract":951},"cordis-european-research-council-award-101077895","Operando Interfacial Ionics","Electrochemistry provides direct control over the electron free energy and thus a path to electrically probe and drive chemical reactions. In strong contrast, no versatile technique exists that controls the free energy of a specific ion directly and in isolation. This has led to poor understanding of interfacial ionics. Take for example water dissociation , which is of key relevance for many energy technologies, such as for producing green H2 in alkaline conditions or bipolar membranes (BPMs) th",{"id":953,"funder":7,"programme":8,"title":954,"piName":10,"institution":366,"country":12,"year":13,"amount":955,"abstract":956},"cordis-european-research-council-award-101076166","Tunnel ionization in three-dimensional tailored light fields","€1,836,780","Tunneling is a non-resonant, quantum mechanical process without any classical analog. The electric field of a strong laser pulse can bend atomic and molecular potentials such that an electron can be liberated via tunneling. This allows for probing properties of atomic and molecular orbitals with subnanometer and attosecond resolution (like a tunneling microscopes tip probes properties of the investigated surface). So far, the electric field vector is restricted to a one-dimensional line (1D, e.g",{"id":958,"funder":7,"programme":8,"title":959,"piName":10,"institution":285,"country":12,"year":13,"amount":960,"abstract":961},"cordis-european-research-council-award-101075426","Consequences of global biodiversity loss and climate change for decomposer communities and implications for forest carbon fluxes","€1,499,830","Forests play a central role for global carbon cycling and biodiversity. Yet, the unabated continuation of climate change and increasing anthropogenic pressure on forest resources are altering forest ecosystems by modifying species composition and ecosystem processes. Increasing temperatures are likely to increase decomposition rates and thus carbon emissions, while the opposite effect may be expected from loss of decomposer biodiversity as land-use intensity increases. However, it remains unknow",{"id":963,"funder":7,"programme":8,"title":964,"piName":10,"institution":965,"country":76,"year":13,"amount":10,"abstract":966},"cordis-european-research-council-award-101076432","The evolution and function of fish TRIM E3 ubiquitin ligases","UNIVERSIDAD DE SANTIAGO DE COMPOSTELA","FishTRIM aims to study the evolution and function of the TRIM family of E3 ubiquitin ligases in fish. This family has undergone several clade-specific expansions across the fish phylogeny, with single-copy mammalian TRIMs frequently present in large numbers in fish genomes. TRIM E3 ligases and their direct interactions with viral proteins are key in host-pathogen relationships, and several fish TRIMs have been associated to antiviral responses. Additionally, positive selection has been observed ",{"id":968,"funder":7,"programme":8,"title":969,"piName":10,"institution":970,"country":744,"year":13,"amount":971,"abstract":972},"cordis-european-research-council-award-101076412","SArkisov Program in HIgher Dimension, over Imperfect fields and for birRegulous maps","UNIVERSITE PARIS-SACLAY","€1,485,725","A fundamental goal of Algebraic Geometry is to classify algebraic varieties up to isomorphism. This is extremely hard, already for surfaces, and open in general. It has become clear that we can only hope for a classification up to birational maps, that is, isomorphisms between dense open sets. Understanding birational maps is therefore a key step towards the classification of algebraic varieties. For one of the largest families of algebraic varieties, so-called Mori fibre spaces, any birational ",{"id":974,"funder":7,"programme":8,"title":975,"piName":10,"institution":300,"country":26,"year":13,"amount":10,"abstract":976},"cordis-european-research-council-award-101076495","The Politics of Wildfires:  A Comparative Study of Norms, Power and Conflict in the Global South","Extreme wildfires have been on the rise across the globe due to climate change and other human actions. Despite the abundant literature on fire ecology and a recognition of the linkages of wildfires to global warming, a patchy understanding of the relationship between fire and anthropogenic actions and their political drivers persists. Social sciences scholarship has mostly focused on fire mitigation and management in the Global North, while complex relationships between societies and fires in t",{"id":978,"funder":7,"programme":8,"title":979,"piName":10,"institution":515,"country":40,"year":13,"amount":10,"abstract":980},"cordis-european-research-council-award-101077492","Transformation towards long-term sustainability beyond Sustainable Development Goals","Countries are not on track to meet the 2030 Agenda for Sustainable Development that comprises 17 Sustainable Development Goals (SDGs) and 169 targets to be achieved by 2030. Although SDGs aim to shift the world onto a sustainable and resilient path, countries are not yet able to make transformative changes for long-term sustainability that requires building social prosperity and foundations within planetary boundaries. Failing to achieve SDGs will negatively affect billions of people and worsen ",{"id":982,"funder":7,"programme":8,"title":983,"piName":10,"institution":984,"country":26,"year":13,"amount":985,"abstract":986},"cordis-european-research-council-award-101078411","Federated and distributed inference leveraging sensing and communication in the computing continuum","UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA","€1,019,000","The integration of sensing and communication is attracting a fervent research activity and will result in a myriad of contextual data that, if properly processed, may enable a better understanding of local and global phenomena while increasing the quality, security, and efficiency of our ecosystems. The computing continuum offers a timely and unique solution for processing such a massive volume of sensed data, as it provides virtually unlimited and widely distributed computing resources. Neverth",{"id":988,"funder":7,"programme":8,"title":989,"piName":10,"institution":990,"country":313,"year":13,"amount":991,"abstract":992},"cordis-european-research-council-award-101076847","Making Migrant Voices Heard through Literature: How Collaboration is Changing the Cultural Field","KATHOLIEKE UNIVERSITEIT LEUVEN","€1,497,620","As initiatives for more diversity and inclusiveness in the cultural field are gaining ground and migration becomes an increasingly important issue on the political agendas of many countries around the world, this project examines the ways in which transnational collaborations create spaces for literary participation of migrants. Situated at the intersection between international relations, comparative literature and business economics, COLLAB analyzes the notion of collaboration from a threefold",{"id":994,"funder":7,"programme":8,"title":995,"piName":10,"institution":743,"country":744,"year":13,"amount":960,"abstract":996},"cordis-european-research-council-award-101077837","Groundwater flow CONtrols on CRitical zonE ThErmal Regime","The foundations of modern hydrogeology have been built within the paradigm of quasi-equilibrium temperature distribution within groundwater systems. The presumed thermal stability of groundwater is vitally important for many groundwater and stream ecosystems which cannot tolerate a wide temperature range and face growing threats from climate and land-use changes. Yet, recent results evidenced the great impact of ongoing atmospheric warming on shallow groundwater temperatures. Groundwater flow is",{"id":998,"funder":7,"programme":8,"title":999,"piName":10,"institution":710,"country":40,"year":13,"amount":1000,"abstract":1001},"cordis-european-research-council-award-101078785","The Impossible and the Imaginable: Late-Medieval Semantics of Impossibility and the Roots of Complex Mathematics","€1,498,894","A popular view in the history of philosophy and science holds that we only conceive what is in some sense possible and cannot truly understand anything intrinsically contradictory. The Chimera is the paradigmatic example of such an inconceivable absolute impossibility in medieval logic. Chimera is a necessarily empty term lacking signification and reference. Analogously premodern mathematics dismisses the square root of a negative number as the impossible result of an impossible operation, i.e. ",{"id":1003,"funder":7,"programme":8,"title":1004,"piName":10,"institution":1005,"country":40,"year":13,"amount":1006,"abstract":1007},"cordis-european-research-council-award-101076726","Growing up among bright books and generous genes: The InterGenerational cycle of educational achievement","STICHTING VU","€1,663,193","Poor educational achievement in childhood is a major risk factor for poor health and low income in adulthood. Poor educational outcomes tend to run in families, generating a cycle of inequality. Children whose parents talk and read less to them, tend to struggle in school. This parent-child association has been interpreted as a causal effect of parenting, but parents provide their children not only with a rearing environment, but also genes. We can only discover causal effects of the home learni",{"id":1009,"funder":7,"programme":8,"title":1010,"piName":10,"institution":743,"country":744,"year":13,"amount":1011,"abstract":1012},"cordis-european-research-council-award-101078782","Fourier Interpolation and Extremal Problems","€1,158,000","In 2006 Cohn and Kumar have conjectured that the A2 lattice is universally optimal, meaning that it has the lowest potential energy among all configurations of the same density for all completely monotone potentials. This conjecture has several very important corollaries. Among other consequences, it is known that it implies a positive solution to the 2D crystallization problem, a major unsolved problem coming from materials science, and it also implies a conjecture on the emergence of the trian",{"id":1014,"funder":7,"programme":8,"title":1015,"piName":10,"institution":118,"country":40,"year":13,"amount":27,"abstract":1016},"cordis-european-research-council-award-101075884","Rediscovering the Wanderer: restoration of sympathico-vagal disbalance in irritable bowel syndrome by neuromodulation – a novel therapeutic concept","Common colloquial phrases like ‘gut feeling’ or ‘butterflies in my belly’ are not just idioms but reflect on the unique communication between gut and brain. The principal interface for this interaction is the autonomic nervous system — a largely subconscious system that manages bodily functions through a delicate balance between its two branches: the sympathetic and parasympathetic nervous systems. The vagus nerve is the main component of the latter. Diminished vagal tone resulting in increased ",{"id":1018,"funder":7,"programme":8,"title":1019,"piName":10,"institution":306,"country":100,"year":13,"amount":1020,"abstract":1021},"cordis-european-research-council-award-101077502","How do tetraspanin proteins organize, shape, and remodel biological membranes?","€1,495,625","Our bodies rely on protein driven shaping and remodelling of our cells’ membranes to function. Uncovering the mechanisms of remodelling of the cell membrane is, therefore, essential for understanding biological processes such as fertilization, but also to allow for precise intervention in them when needed. The interplay between protein position, membrane tension, and local curvature is believed to dictate these processes. However, experimental verifications of this hypothesis in specific biologi",{"id":1023,"funder":7,"programme":8,"title":1024,"piName":10,"institution":521,"country":33,"year":13,"amount":1025,"abstract":1026},"cordis-european-research-council-award-101075733","Deciphering the antibody-microbiota axis in early life","€1,650,000","Immunoglobulins (Igs) are thought to influence formation of the microbiota composition during a critical window of opportunity in early life. Yet, the antigen binding profiles of these Igs are vastly unknown, and it is incompletely understood how early misguided immune education contributes to the development of allergies or asthma. On an even more fundamental level, it is also unclear if or how B cell receptor (BCR) sequences of different individuals converge to binding similar microbiota antig",{"id":1028,"funder":7,"programme":8,"title":1029,"piName":10,"institution":443,"country":377,"year":13,"amount":27,"abstract":1030},"cordis-european-research-council-award-101078303","Evolutionary dynamics of genomic erosion and its application in biodiversity conservation","Reducing biodiversity loss is one of the most pressing societal challenges of our time. Population decline has put many species on the path of collapse and extinction. Reducing or reversing this decline is not enough to tackle the associated hidden evolutionary costs, most notably genomic erosion which compromises the long-term viability and resilience of species. ERODE will employ state-of-the-art approaches – (paleo)genomics, quantitative genomics, and evolutionary modelling – to assess the dy",{"id":1032,"funder":7,"programme":8,"title":1033,"piName":10,"institution":515,"country":40,"year":13,"amount":27,"abstract":1034},"cordis-european-research-council-award-101076441","In Vitro Reconstitution of the Minimal Eukaryotic Cell Cycle Oscillator","Cell growth and division are the basis of all forms of life. In eukaryotes, the clock-like cycles of genome duplication and cell division are orchestrated by a complex set of biochemical reactions. Theory suggests that a negative feedback loop regulating the cyclin-dependent kinase 1 generates the cell cycle oscillations; however, because the putative cell cycle ‘clock’ is tightly interlinked with numerous other biological networks, experimental validation has proven to be a challenge. To date, ",{"id":1036,"funder":7,"programme":8,"title":1037,"piName":10,"institution":443,"country":377,"year":13,"amount":27,"abstract":1038},"cordis-european-research-council-award-101076758","The transcriptional response to oxidative stress","Environmental stress triggers a cellular response to promote adaptation and survival, typically through activation of stress genes. What is less appreciated is that various types of cellular stress at the same time induce widespread transcriptional repression at most other genes. Although such transcriptional reprogramming is common to various kinds of cellular stress, recent evidence suggests it is governed by different stress-specific mechanisms. A brief exposure to oxidative stress leads to a",{"id":1040,"funder":7,"programme":8,"title":1041,"piName":10,"institution":306,"country":100,"year":13,"amount":27,"abstract":1042},"cordis-european-research-council-award-101078772","Exploring Nuclear Aspects of Neutrino Interactions in Neutrino Oscillation Experiments","The ability of current and next generation accelerator based neutrino oscillation measurements to reach their desired sensitivity and provide new insight into the nature of our Universe, requires a high-level of understanding of the neutrino-nucleus interactions. These include precise estimation of the relevant cross sections and the reconstruction of the incident neutrino energy from the measured final state particles. Incomplete understanding of these interactions can skew the reconstructed ne",{"id":1044,"funder":7,"programme":8,"title":1045,"piName":10,"institution":312,"country":313,"year":13,"amount":1046,"abstract":1047},"cordis-european-research-council-award-101076597","Strongly interacting electrons in synthetic superlattices","€1,490,000","Recent experiments on a class of atomically-thin two-dimensional materials, called moiré superlattice systems, have uncovered an entirely new and fascinating world of enigmatic strong-correlation physics and superconductivity. This project will develop theoretical models to explain these intriguing experimental observations. Numerical simulations will play an important role in guiding the theoretical models. An overarching goal is also to explore what lessons we can learn from moiré materials th",{"id":1049,"funder":7,"programme":8,"title":1050,"piName":10,"institution":148,"country":26,"year":13,"amount":27,"abstract":1051},"cordis-european-research-council-award-101078646","Breaking oncometabolites dynamics for next-generation dendritic cells tumor immunotherapy","Owing to an increased appreciation of the potential for immunotherapy in neoplasia, much attention has been focuing on a greater understanding of the immune, bidirectional intricacies involving the Tumor MicroEnvironment (TME). Recent work has demonstrated that TME elicits environmental changes, metabolic in nature, in the host’s immune cells, that dampen their ability to REACT against tumors. Manipulating the biology of oncometabolites can strengthen an antitumor immune response as well as circ",{"id":1053,"funder":7,"programme":8,"title":1054,"piName":10,"institution":360,"country":12,"year":13,"amount":1055,"abstract":1056},"cordis-european-research-council-award-101077866","Molecular Spins for Quantum Technology","€1,893,184","Defect spins in solids provide a promising platform to realize a range of quantum technologies. Recent advances demonstrated their basic functionalities as quantum network nodes. Yet, the realization of a real-scale quantum network requires solving outstanding challenges posed by the inhomogeneity of elementary systems and decoherence from environmental couplings.MSpin aims to tackle these challenges employing a bottom-up route. A single molecule sets a compact, nanoscopic stage to house an arra",{"id":1058,"funder":7,"programme":8,"title":1059,"piName":10,"institution":851,"country":26,"year":13,"amount":1060,"abstract":1061},"cordis-european-research-council-award-101075832","Single-Atom Catalysts for a New Generation of Chemical Processes: from Fundamental Understanding to Interface Engineering","€1,499,681","The grand challenge for the chemical industries of the 21st century is the transition to more sustainable manufacturing processes that efficiently use raw materials and eliminate waste. Catalysis engineering is the key enabling technology to drive this transition, and single-atom catalysis is an emerging new approach to catalyst design. However, major questions concerning the local structure of these systems, their reactivity, and their evolution when prepared and structurally integrated into ch",{"id":1063,"funder":7,"programme":8,"title":1064,"piName":10,"institution":118,"country":40,"year":13,"amount":27,"abstract":1065},"cordis-european-research-council-award-101076292","Responsive Law for Global Value Chains","CHAINLAW will develop a novel conceptual and normative legal language for Global Value Chains (GVCs). GVCs are the interconnected trade structures that underlie the production of commodities and offering of services. While GVCs have been intensively theorised in the social sciences, they are largely unknown as legal categories. This is highly problematic when the law is starting to legislate or decide cases about supply-chain responsibility.The core aim of CHAINLAW is to provide the concepts nec",{"id":1067,"funder":7,"programme":8,"title":1068,"piName":10,"institution":1069,"country":125,"year":13,"amount":1070,"abstract":1071},"cordis-european-research-council-award-101076207","From light fueled self-oscillators to light communicating material networks","TAMPEREEN KORKEAKOULUSAATIO SR","€1,495,500","ONLINE aims to develop new concepts of communication between inanimate materials.What is meant by communication? In biological context, communication refers to interactive behaviour of one organism affecting the current or future behaviour of another. In the context of bioinspired materials, ONLINE will develop life-like material structures that communicate with each other via physical contact, fluidic medium, or optical beams. These inanimate materials will be coupled to form networks that comm",{"id":1073,"funder":7,"programme":8,"title":1074,"piName":10,"institution":515,"country":40,"year":13,"amount":1075,"abstract":1076},"cordis-european-research-council-award-101075461","Sweet adhesins: Probing bacterial glycoproteins with novel tools to inspire future antibacterial strategies","€1,499,251","With bacteria increasingly resistant to current antibiotics, new strategies to fight infection are needed. Bacterial adhesin proteins, which play an important role in the establishment of infection, appear to be promising targets for novel therapies. Adhesins enable the first contact between bacteria and host cells. We know that some adhesins are modified with highly unique sugars that are important for adhesin stability and adherence. However, we do not know how widespread this modification is,",{"id":1078,"funder":7,"programme":8,"title":1079,"piName":10,"institution":1080,"country":700,"year":13,"amount":1081,"abstract":1082},"cordis-european-research-council-award-101076710","Untangling population representations of objects. A closed loop approach to link neural activity to mouse behavior.","IDRYMA TECHNOLOGIAS KAI EREVNAS","€1,900,000","A paramount component of intelligence is our ability to extract useful information in the world through our sensory observations. Object recognition is a fundamental problem in visual perception: every day we depend on our ability to identify objects in our visual environment, and our brain is capable of accomplishing it effortlessly and in a fraction of a second, in spite of immense variation in the sensory information that arrives in our retinas. Understanding the algorithm that the brain uses",{"id":1084,"funder":7,"programme":8,"title":1085,"piName":10,"institution":851,"country":26,"year":13,"amount":1086,"abstract":1087},"cordis-european-research-council-award-101077181","ManipULation of photoinduced processes bY reshaping tranSition StatEs via transient Strong coupling","€1,497,100","Photochemistry deals with the light-assisted transformation of molecules into useful products. These processes are routinely manipulated by chemical modification and external laser driving. Femtosecond coherent control uses ultrashort pulses to initiate and actively modulate a chemical reaction. However successful control of efficiency and specificity of a chemical process is still awaited.ULYSSES proposes a radical departure from the way chemical processes are currently controlled by light. I w",{"id":1089,"funder":7,"programme":8,"title":1090,"piName":10,"institution":312,"country":313,"year":13,"amount":224,"abstract":1091},"cordis-european-research-council-award-101078339","Violence work: Creating and Contesting Colonial Authority on the Ground in Africa through Everyday Violence","VIOLENCE WORK is a groundbreaking study of everyday violence in Belgian Central Africa—Burundi, Congo, and Rwanda (19th-20th C). Though colonial violence has been studied widely, few have explored how everyday violence enabled colonialism and allowed it to persist. This project combines hitherto neglected source materials and a novel conceptual entry point—violence work(ers)—to foreground the everyday violent practices crucial to creating and maintaining the colonial state. 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