[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-synergy-grant-2019":3,"awarded-stats-erc-synergy-grant":177},{"awarded":4,"total":176},[5,16,23,29,36,41,48,55,61,67,73,79,85,91,98,105,111,117,122,128,134,140,146,152,158,165,171],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-european-research-council-award-810104","European Research Council","ERC Synergy Grant","Principles of Integrin Mechanics and Adhesion",null,"MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV","DE",2019,"€7,217,200","Integrin-mediated adhesion to the extracellular matrix is a prerequisite for the development and homeostasis of multicellular organisms. A hallmark of integrins is that ligand binding requires an “integrin activation” step affecting the shape of the entire molecule is induced by the integrin tail- and actomyosin-binding adaptor proteins talin and kindlin. In a second step, integrins cluster and assemble a gigantic signaling hub, where they integrate biochemical and biophysical signals to achieve",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":20,"year":13,"amount":21,"abstract":22},"cordis-european-research-council-award-810573","Recursive and Exact New Quantum Theory","SYDDANSK UNIVERSITET","DK","€9,815,468","The overarching goal of ReNewQuantum is to renew the mathematical foundation behind quantum phenomena.We aim to construct a recursive and exact new approach to quantum theory. Quantum theory is one of the pillars of modern science. Its success stretches from elementary quantum mechanical models, developed a century ago by quantization of classical mechanics, to advanced quantum field theories such as the standard model of particle physics, which is the quantization of a gauge theory. However, a ",{"id":24,"funder":7,"programme":8,"title":25,"piName":10,"institution":26,"country":27,"year":13,"amount":10,"abstract":28},"cordis-european-research-council-award-810451","Hidden, entangled and resonating orders","PAUL SCHERRER INSTITUT","CH","Knowledge of the electronic band structure and a key low energy degree of freedom, chosen from a short list including charge, spin, free electrons and atomic positions, characterizes most crystalline solids with astonishing success. This paradigm underpins not only metallic and insulating behavior, but also superconductivity, the fractional quantum Hall effect and Mott physics where the efficient theoretical approach is always to consider many-body physics only for a single low energy degree of ",{"id":30,"funder":7,"programme":8,"title":31,"piName":10,"institution":32,"country":33,"year":13,"amount":34,"abstract":35},"cordis-european-research-council-award-810367","Extreme-scale Mathematically-based Computational Chemistry","SORBONNE UNIVERSITE","FR","€9,991,997","Molecular simulation has become an instrumental tool in chemistry, condensed matter physics, molecular biology, materials science, and nanosciences. It will allow to propose de novo design of e.g. new drugs or materials provided that the efficiency of underlying software is accelerated by several orders of magnitude.The ambition of the EMC2 project is to achieve scientific breakthroughs in this field by gathering the expertise of a multidisciplinary community at the interfaces of four discipline",{"id":37,"funder":7,"programme":8,"title":38,"piName":10,"institution":11,"country":12,"year":13,"amount":39,"abstract":40},"cordis-european-research-council-award-810131","Plant Mobile RNAs: Function, Transport and Features","€6,134,102","An essential consequence of multi-cellularity is the need for intercellular and tissue wide communication. As seen with animals, higher plants coordinate metabolic and developmental processes via signals transferred to different body parts. Plants use a dual vascular system consisting of phloem and xylem for long-distance transfer of metabolites and signalling molecules. In contrast to circular systems in animals, transport in flowering plants occurs in the phloem via the cytoplasm of connected ",{"id":42,"funder":7,"programme":8,"title":43,"piName":10,"institution":44,"country":45,"year":13,"amount":46,"abstract":47},"cordis-european-research-council-award-810370","Climate CT- Cloud Tomography by Satellites for Better Climate Prediction","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","IL","€13,878,593","Clouds play a lead climatic role, controlling energy fluxes and regulating fresh water distribution. There is an acute need for cloud-resolving and global-climate models that accurately describe and parametrize the physics of warm convective and stratiform clouds, and the clouds’ sensitivity to environmental changes. Currently this requirement is not being met due to a gap in observational capabilities. Namely, there is a lack of sufficient sensing tailored to capture the 3D macro and microphysi",{"id":49,"funder":7,"programme":8,"title":50,"piName":10,"institution":51,"country":52,"year":13,"amount":53,"abstract":54},"cordis-european-research-council-award-810287","Single-cell genomics to comprehensively understand healthy B-cell maturation and transformation to chronic lymphocytic leukemia","CONSORCIO PARA LA EXPLOTACION DEL CENTRO NACIONAL DE ANALISIS GENOMICO","ES","€8,333,331","Unbiased analyses of the molecular make up of single cells are revolutionizing our understanding of cell differentiation and cancer. Over the last years, our groups have characterized the molecular features of normal B-cell subpopulations and of pools of leukemic cells from chronic lymphocytic leukemia (CLL), the most frequent leukemia in the Western world. These analyses have revealed that CLL subtypes are related to different B-cell maturation stages, and that they can show a complex subclonal",{"id":56,"funder":7,"programme":8,"title":57,"piName":10,"institution":58,"country":45,"year":13,"amount":59,"abstract":60},"cordis-european-research-council-award-810186","Widespread Bacterial CORE Complex Executes Intra- and Inter-Kingdom  Cytoplasmic Molecular Trade","THE HEBREW UNIVERSITY OF JERUSALEM","€6,930,796","The enormous versatility of bacteria enables the formation of multi-species communities that colonize nearly every niche on earth, making them the dominant life form and a major component of the biomass. Exchange of molecular information among neighboring bacteria in such communities, as well as between bacteria and proximal eukaryotic cells, is key for bacterial success. Yet, the principles controlling these multicellular interactions are poorly defined. Here we describe the identification of a",{"id":62,"funder":7,"programme":8,"title":63,"piName":10,"institution":64,"country":12,"year":13,"amount":65,"abstract":66},"cordis-european-research-council-award-810316","Advancing osteoporosis medicine by observing bone microstructure and remodelling using a four-dimensional nanoscope","UNIVERSITATSKLINIKUM ERLANGEN","€12,366,635","Due to Europe's ageing society, there has been a dramatic increase in the occurrence of osteoporosis (OP) and related diseases. Sufferers have an impaired quality of life, and there is a considerable cost to society associated with the consequent loss of productivity and injuries. The current understanding of this disease needs to be revolutionized, but study has been hampered by a lack of means to properly characterize bone structure, remodeling dynamics and vascular activity. This project, 4D ",{"id":68,"funder":7,"programme":8,"title":69,"piName":10,"institution":70,"country":27,"year":13,"amount":71,"abstract":72},"cordis-european-research-council-award-810057","A synergistic approach toward understanding receptor signaling in the cell at very high resolution","UNIVERSITAT ZURICH","€8,273,457","Members of the Epidermal Growth Factors Receptor family (EGFRs) influence cell growth and proliferation, and are pivotal in all phases of tumor progression. We will use this receptor family as an example with which to develop a ground-breaking new technology to study cellular signaling towards atomic resolution, in situ. Therefore, we propose to employ an interdisciplinary approach for studying EGFR family of receptors, where we follow their conformational and oligomeric states as well as bound ",{"id":74,"funder":7,"programme":8,"title":75,"piName":10,"institution":76,"country":52,"year":13,"amount":77,"abstract":78},"cordis-european-research-council-award-810141","The European Qur'an. Islamic Scripture in European Culture and Religion 1150-1850","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","€9,842,534","“The European Qur’an” (EuQu) will study the place of the Muslim holy book in European cultural and religious history (c.1150-1850), situating European perceptions of the Qur’an and of Islam in the fractured religious, political, and intellectual landscape of this long period. The Qur’an plays a key role not only in polemical interactions with Islam, but also in debates between Christians of different persuasions and is central to the epistemological reconfigurations that are at the basis of mode",{"id":80,"funder":7,"programme":8,"title":81,"piName":10,"institution":82,"country":33,"year":13,"amount":83,"abstract":84},"cordis-european-research-council-award-810331","Well-Aging and the Tanycytic Control of Health","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","€9,866,250","The survival of an organism depends on energy homeostasis, involving the control of neuroendocrine functions that integrate metabolic feedback and adapt the response of the organism to physiological demands. Tanycytes, specialized glial cells lining the floor of the third ventricle in the median eminence of the hypothalamus, act as linchpins of these processes, dynamically controlling the secretion of neuropeptides by hypothalamic neurons into the pituitary portal circulation and regulating bloo",{"id":86,"funder":7,"programme":8,"title":87,"piName":10,"institution":88,"country":12,"year":13,"amount":89,"abstract":90},"cordis-european-research-council-award-810296","Decoding Context-Dependent Genetic Networks in vivo","DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG","€10,625,000","The evolutionary success of multicellular organisms is based on the division of labor between cells. While some of the molecular determinants for cell fate specification have been identified, a fundamental understanding of which genetic activities are required in each cell of a developing tissue is still outstanding. The DECODE project will develop and apply leading-edge system genetics methods to Arabidopsis and Drosophila, two major model systems from the plant and animal kingdoms to decode co",{"id":92,"funder":7,"programme":8,"title":93,"piName":10,"institution":94,"country":95,"year":13,"amount":96,"abstract":97},"cordis-european-research-council-award-810207","Defining the role of Arp2\u002F3 complex diversity at multiple scales of biology","THE FRANCIS CRICK INSTITUTE LIMITED","UK","€10,715,153","The actin cytoskeleton of the cell is critical for the complex, integrated processes associated with development, operation and sustainability of the human body. The Arp2\u002F3 complex consisting of seven protein subunits is essential to stimulate dynamic branched actin networks needed for multiple cellular processes. The Arp2\u002F3 complex has always been considered as a single entity, but in humans and other mammals, three of the Arp2\u002F3 complex subunits are encoded by two isoforms, thus allowing the f",{"id":99,"funder":7,"programme":8,"title":100,"piName":10,"institution":101,"country":102,"year":13,"amount":103,"abstract":104},"cordis-european-research-council-award-810377","Connecting to the Networks of the Human Brain","AALTO KORKEAKOULUSAATIO SR","FI","€9,981,794","ConnectToBrain will introduce whole-brain multi-locus transcranial magnetic stimulation (mTMS), in which the brain-stimulating electric-field location, direction, magnitude and timing are controlled electronically based on real-time high-density electroencephalography (hdEEG) information of activity and connectivity in brain networks. The final mTMS apparatus will consist of 50 coils. Superpositions of electric fields produced by the different overlapping coils allow spatiotemporally millimeter-",{"id":106,"funder":7,"programme":8,"title":107,"piName":10,"institution":108,"country":27,"year":13,"amount":109,"abstract":110},"cordis-european-research-council-award-810111","From Epigenetics of Cranial Neural Crest Plasticity to Intervertebral Disc Regeneration","FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION","€5,330,000","During craniofacial development, Cranial Neural Crest Cells (CNCCs) maintain broad plasticity and patterning competence until they make appropriate cartilage and bone structures in response to local cues. We found that CNCC embryonic plasticity involves a specific epigenetic chromatin signature that maintains genes, including Hox genes, in a transcriptionally silent but poised state, so that they can be readily switched to an active state in response to position-specific environmental signals. A",{"id":112,"funder":7,"programme":8,"title":113,"piName":10,"institution":114,"country":33,"year":13,"amount":115,"abstract":116},"cordis-european-research-council-award-810218","The Whole Sun Project: Untangling the complex physical mechanisms behind our eruptive star and its twins","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","€11,238,375","We live around an active magnetic star, our Sun, that has a direct impact on our technological society through its variability and eruptive behaviour. Despite decades of intense research, fundamental questions such as How does the Sun work? Why does it possess a magnetic cycle and a dynamic hot atmosphere and how they are interrelated? remain mostly unanswered. In the Whole Sun project, we aim at tackling these key questions as a coherent whole for the first time. For too many years, the Sun has",{"id":118,"funder":7,"programme":8,"title":119,"piName":10,"institution":114,"country":33,"year":13,"amount":120,"abstract":121},"cordis-european-research-council-award-810504","3D integration technology for silicon spin qubits","€13,990,460","Originally conceived to describe the microscopic world of atoms and elementary particles, the theory of quantum mechanics has eventually served to predict macroscopic phenomena, e.g. the electrical and optical properties of semiconductors, resulting a wide range of technological applications that have changed our way of living. Foundational properties like quantum superposition and entanglement, however, have remained essentially unexploited.  Their use may allow achieving computational powers i",{"id":123,"funder":7,"programme":8,"title":124,"piName":10,"institution":125,"country":95,"year":13,"amount":126,"abstract":127},"cordis-european-research-council-award-810346","Natural Integration of Bionic Limbs via Spinal Interfacing","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€9,984,021","Missing a limb leads to dramatic impairments in the capacity to move and interact with the environment and to a substantial worsening in quality of life. This deficiency is also associated with a large portion of the sensory-motor cortex facing neural deafness. Missing or damaged limbs can in principle be substituted by robotic limbs, connected to humans with neural interfacing. Despite massive research efforts, however, the bionic reconstruction of limbs currently faces important translational ",{"id":129,"funder":7,"programme":8,"title":130,"piName":10,"institution":131,"country":132,"year":13,"amount":10,"abstract":133},"cordis-european-research-council-award-810356","Policy Crisis and Crisis Politics. Sovereignty, Solidarity and Identity in the EU post 2008.","UNIVERSITA DEGLI STUDI DI MILANO","IT","During the post 2008 decennium horribile the EU has been faced with unprecedented shocks (the Euro-crisis, the Great Recession and its dramatic social consequences, new security threats, the refugee crisis, Brexit) which have coalesced in a disruptive dynamic of unprecedented scope and depth. Conflicts over sovereignty, solidarity and identity sparked a “deep” political crisis, shaking the very foundations of the EU. Surprisingly, however, the utter collapse of the Union has been averted. In dra",{"id":135,"funder":7,"programme":8,"title":136,"piName":10,"institution":137,"country":33,"year":13,"amount":138,"abstract":139},"cordis-european-research-council-award-809994","The Domestication of ‘Hindu’ Asceticism and the Religious Making of South and Southeast Asia","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","€9,820,868","Censuses report over a billion “Hindus” in the world today. But what is “Hinduism”? In answer, many accounts describe the doctrinal evolutions of various quite different currents of thought. To try to reply using material and social evidence is difficult because so many vital primary sources for institutional history remain inaccessible.What were the material foundations of the constellation of religious movements today classed as “Hindu”? How have different forms of religious agency shaped the ",{"id":141,"funder":7,"programme":8,"title":142,"piName":10,"institution":143,"country":12,"year":13,"amount":144,"abstract":145},"cordis-european-research-council-award-810172","Genetics of Individuality","EUROPEAN MOLECULAR BIOLOGY LABORATORY","€6,272,613","We propose to thoroughly investigate and characterise the sources of variation that results in varying phenotypes in a complex vertebrate. As well as characterising the genetic and environmental sources of variation, we will also investigate individual stochastic variation present even in fixed settings (both genetically and environmentally). To achieve this we will exploit the unique properties of Medaka fish, which can be fully inbred from the wild. We have already inbred and performed whole g",{"id":147,"funder":7,"programme":8,"title":148,"piName":10,"institution":149,"country":95,"year":13,"amount":150,"abstract":151},"cordis-european-research-council-award-810002","Radical pair-based magnetic sensing in migratory birds","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€8,561,588","The navigational and sensory abilities of night-migratory songbirds, travelling alone over thousands of kilometres, are absolutely staggering. The successful completion of these magnificent voyages depends crucially on the birds’ ability to sense the Earth’s magnetic field. Exactly how this magnetic sense works is one of the most significant open questions in biology and biophysics. The experimental evidence suggests something extraordinary. The birds’ magnetic compass sensor seems to rely on co",{"id":153,"funder":7,"programme":8,"title":154,"piName":10,"institution":155,"country":27,"year":13,"amount":156,"abstract":157},"cordis-european-research-council-award-810586","Exploring the dynamics and causes of prehistoric land use change in the cradle of European farming","UNIVERSITAET BERN","€6,403,199","European societies today face unprecedented environmental change. Understanding how human societies responded to past challenges of environmental change relates to the interface between culture and environment. The EXPLO project proposes a novel interdisciplinary approach to investigate key questions regarding the interaction between past human ways of life, land use and the wider environment through a unique combination of archaeological, biological and dynamic mathematical modelling approaches",{"id":159,"funder":7,"programme":8,"title":160,"piName":10,"institution":161,"country":162,"year":13,"amount":163,"abstract":164},"cordis-european-research-council-award-810115","Dynamics and Structure of Networks","HUN-REN RENYI ALFRED MATEMATIKAI KUTATOINTEZET","HU","€9,315,424","Networks define our life, being essential to cell biology, communications, social and economic systems, and impacting virtually all areas of science and technology. The aim of this proposal is to engage leading experts in network science and graph theory to build a mathematically sound theory of dynamical networks, which will be transformative to our understanding of complex systems, with applications in multiple disciplines. Both fields have made major conceptual advances in the past decade: ne",{"id":166,"funder":7,"programme":8,"title":167,"piName":10,"institution":168,"country":12,"year":13,"amount":169,"abstract":170},"cordis-european-research-council-award-810580","The self-teaching brain","HUMBOLDT-UNIVERSITAET ZU BERLIN","€9,781,250","Our goal is to uncover the learning algorithms that subserve biological intelligence and to discover how they are implemented in the brain. We take for granted that biological intelligence results from neural information processing, that neural information processing is based on the transmission of action potentials through synapses, and that learning is realized through synaptic plasticity. We are inspired by two key observations: Firstly, we know that biological learning unfolds in ways differ",{"id":172,"funder":7,"programme":8,"title":173,"piName":10,"institution":174,"country":132,"year":13,"amount":10,"abstract":175},"cordis-european-research-council-award-810182","Surface-COnfined fast-modulated Plasma for process and Energy intensification in small molecules conversion","UNIVERSITA DEGLI STUDI DI MESSINA","The SCOPE project will introduce a ground-breaking approach to use renewable energy in three major industrial reactions: 1) N2 fixation, 2) CH4 valorization and 3) CO2 conversion to liquid solar fuels. We will use non-thermal plasma, which has large potential to convert these small (low reactive) molecules under near ambient temperature and pressure, particularly for distributed processes based on renewable energy. The new processes have drastically lower carbon footprint (up to over 90% with re",27,{"programme":8,"total":178,"withPiName":179,"firstYear":180,"lastYear":181,"countryCount":182,"perYear":183,"topInstitutions":214,"topCountries":271},335,21,2013,2026,28,[184,186,188,191,193,194,197,200,203,206,209,212],{"year":180,"count":185},11,{"year":187,"count":185},2014,{"year":189,"count":190},2015,2,{"year":192,"count":190},2018,{"year":13,"count":176},{"year":195,"count":196},2020,37,{"year":198,"count":199},2021,34,{"year":201,"count":202},2022,8,{"year":204,"count":205},2023,33,{"year":207,"count":208},2024,38,{"year":210,"count":211},2025,58,{"year":181,"count":213},74,[215,218,221,223,226,228,231,233,235,238,240,242,244,246,248,250,253,255,257,259,261,263,265,267,269],{"name":216,"count":217},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",24,{"name":219,"count":220},"Centre National de la Recherche Scientifique CNRS",16,{"name":222,"count":202},"University of Cambridge",{"name":224,"count":225},"Institut National de la Sante Et de la Recherche Medicale",6,{"name":227,"count":225},"Kobenhavns Universitet",{"name":229,"count":230},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",5,{"name":232,"count":230},"Stichting Radboud Universiteit",{"name":234,"count":230},"Universitetet I Oslo",{"name":236,"count":237},"Commissariat A L Energie Atomique Et Aux Energies Alternatives",4,{"name":239,"count":237},"Forschungszentrum Julich Gmbh",{"name":241,"count":237},"Norges Teknisk-Naturvitenskapelige Universitet Ntnu",{"name":243,"count":237},"Technische Universiteit Delft",{"name":245,"count":237},"Tel Aviv University",{"name":247,"count":237},"Universitat Wien",{"name":249,"count":237},"University of Oxford",{"name":251,"count":252},"Aarhus Universitet",3,{"name":254,"count":252},"Ecole Polytechnique Federale de Lausanne",{"name":256,"count":252},"Eidgenoessische Technische Hochschule Zuerich",{"name":258,"count":252},"European Molecular Biology Laboratory",{"name":260,"count":252},"Gfz Helmholtz-Zentrum Fur Geoforschung",{"name":262,"count":252},"Humboldt-Universitaet Zu Berlin",{"name":264,"count":252},"Imperial College of Science Technology and Medicine",{"name":266,"count":252},"King's College London",{"name":268,"count":252},"Rheinische Friedrich-Wilhelms-Universitat Bonn",{"name":270,"count":252},"Universite Catholique de Louvain",[272,274,276,278,279,281,283,284,286,288,291,294,295,298,300,302,303,304,306,308,310,313,315,317,319],{"name":12,"count":273},82,{"name":33,"count":275},43,{"name":95,"count":277},29,{"name":52,"count":176},{"name":280,"count":217},"NL",{"name":27,"count":282},18,{"name":132,"count":282},{"name":20,"count":285},14,{"name":287,"count":285},"NO",{"name":289,"count":290},"AT",12,{"name":292,"count":293},"SE",10,{"name":45,"count":202},{"name":296,"count":297},"BE",7,{"name":299,"count":237},"GB",{"name":301,"count":252},"CZ",{"name":102,"count":252},{"name":162,"count":252},{"name":305,"count":252},"IE",{"name":307,"count":190},"HR",{"name":309,"count":190},"PL",{"name":311,"count":312},"CN",1,{"name":314,"count":312},"CY",{"name":316,"count":312},"EL",{"name":318,"count":312},"IN",{"name":320,"count":312},"LU"]