[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-erc-synergy-grant-2022":3,"awarded-stats-erc-synergy-grant":63},{"awarded":4,"total":62},[5,15,22,29,36,43,50,56],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":10,"abstract":14},"cordis-european-research-council-award-951644","European Research Council","ERC Synergy Grant","Switchable rhodOpsins in Life Sciences",null,"PAUL SCHERRER INSTITUT","CH",2022,"Bistable rhodopsins are naturally photosensitive G-protein coupled receptors (GPCRs) that can be toggled between stable ON and OFF states using light. They are responsible for photosensitivity and vision across animals (including humans), and a potential source of powerful optogenetic tools enabling bidirectional control of influential intracellular signalling cascades across all body systems using light. Lack of understanding of structure-function relationships for these proteins curtails under",{"id":16,"funder":7,"programme":8,"title":17,"piName":18,"institution":19,"country":20,"year":13,"amount":10,"abstract":21},"openalex-european-research-council-award-erc-syg-2020-951475","High-throughput proteomics of nanogram-scale samples with Zeno SWATH MS","Ziyue Wang","Humboldt-Universität zu Berlin","DE","The possibility to record proteomes in high throughput and at high quality has opened new avenues for biomedical research, drug discovery, systems biology, and clinical translation. However, high-throughput proteomic experiments often require high sample amounts and can be less sensitive compared to conventional proteomic experiments. Here, we introduce and benchmark Zeno SWATH MS, a data-independent acquisition technique that employs a linear ion trap pulsing (Zeno trap pulsing) to increase the",{"id":23,"funder":7,"programme":8,"title":24,"piName":25,"institution":26,"country":27,"year":13,"amount":10,"abstract":28},"openalex-european-research-council-award-erc-syg-855158","Chromosome Inequality: Causes and Consequences of Non-Random Segregation Errors in Mitosis and Meiosis","Geert J.P.L. Kops","Royal Netherlands Academy of Arts and Sciences","NL","Aneuploidy is a hallmark of cancer and a major cause of miscarriages in humans. It is caused by chromosome segregation errors during cell divisions. Evidence is mounting that the probability of specific chromosomes undergoing a segregation error is non-random. In other words, some chromosomes have a higher chance of contributing to aneuploid karyotypes than others. This could have important implications for the origins of recurrent aneuploidy patterns in cancer and developing embryos. Here, we r",{"id":30,"funder":7,"programme":8,"title":31,"piName":32,"institution":33,"country":34,"year":13,"amount":10,"abstract":35},"openalex-european-research-council-award-erc-synergy-grant-855158","Augmin prevents merotelic attachments by promoting proper arrangement of bridging and kinetochore fibers","Iva M. Tolić","Ruđer Bošković Institute","HR","The human mitotic spindle is made of microtubules nucleated at centrosomes, at kinetochores, and from pre-existing microtubules by the augmin complex. However, it is unknown how the augmin-mediated nucleation affects distinct microtubule classes and thereby mitotic fidelity. Here, we use superresolution microscopy to analyze the previously indistinguishable microtubule arrangements within the crowded metaphase plate area and demonstrate that augmin is vital for the formation of uniformly arrange",{"id":37,"funder":7,"programme":8,"title":38,"piName":39,"institution":40,"country":41,"year":13,"amount":10,"abstract":42},"openalex-european-research-council-award-synergy-qxtreme","Dry launching of silica nanoparticles in vacuum","Markus Aspelmeyer","University of Vienna","AT","Clean loading of silica nanoparticles with a radius as small as ∼50 nm is required for experiments in levitated optomechanics that operate in ultra-high vacuum. We present a cheap and simple experimental method for dry launching of silica nanoparticles by shaking from a polytetrafluoroethylene surface (PTFE). We report on the successful launching of single silica nanoparticles with a minimum radius of 43 nm, which is enabled by the low stiction to the launching surface. Nanoparticles with radii ",{"id":44,"funder":7,"programme":8,"title":45,"piName":46,"institution":47,"country":48,"year":13,"amount":10,"abstract":49},"openalex-european-research-council-award-erc-synergy-grant","Cross-linker design determines microtubule network organization by opposing motors","Thomas Surrey","Institució Catalana de Recerca i Estudis Avançats","ES","During cell division, cross-linking motors determine the architecture of the spindle, a dynamic microtubule network that segregates the chromosomes in eukaryotes. It is unclear how motors with opposite directionality coordinate to drive both contractile and extensile behaviors in the spindle. Particularly, the impact of different cross-linker designs on network self-organization is not understood, limiting our understanding of self-organizing structures in cells but also our ability to engineer ",{"id":51,"funder":7,"programme":8,"title":52,"piName":53,"institution":54,"country":20,"year":13,"amount":10,"abstract":55},"openalex-european-research-council-award-synergy-grant-4d-nanoscope","Neutralizing monoclonal antibodies against SARS-CoV-2 for COVID-19 pneumonia in a rituximab treated patient with systemic sclerosis—A case report and literature review","David Simón","Universitätsklinikum Erlangen","Patients with immune-mediated diseases (IMID) such as systemic sclerosis (SSc), who are treated with B cell depleting treatments, are at risk for developing severe COVID-19 due to inadequate humoral immune response. During B cell depletion, therapeutic substitution of neutralizing monoclonal antibodies against the SARS-CoV-2 spike protein (mAbs) might be helpful to prevent severe COVID-19. It has been shown, that in non-IMID patients mABs reduce SARS-CoV-2 viral load and lower the risk of COVID-",{"id":57,"funder":7,"programme":8,"title":58,"piName":59,"institution":60,"country":12,"year":13,"amount":10,"abstract":61},"openalex-european-research-council-award-synergy-grant-609883","Multi-omics subtyping of hepatocellular carcinoma patients using a Bayesian network mixture model","Niko Beerenwinkel","SIB Swiss Institute of Bioinformatics","Comprehensive molecular characterization of cancer subtypes is essential for predicting clinical outcomes and searching for personalized treatments. We present bnClustOmics, a statistical model and computational tool for multi-omics unsupervised clustering, which serves a dual purpose: Clustering patient samples based on a Bayesian network mixture model and learning the networks of omics variables representing these clusters. The discovered networks encode interactions among all omics variables ",8,{"programme":8,"total":64,"withPiName":65,"firstYear":66,"lastYear":67,"countryCount":68,"perYear":69,"topInstitutions":100,"topCountries":157},335,21,2013,2026,28,[70,72,74,77,79,82,85,88,89,92,95,98],{"year":66,"count":71},11,{"year":73,"count":71},2014,{"year":75,"count":76},2015,2,{"year":78,"count":76},2018,{"year":80,"count":81},2019,27,{"year":83,"count":84},2020,37,{"year":86,"count":87},2021,34,{"year":13,"count":62},{"year":90,"count":91},2023,33,{"year":93,"count":94},2024,38,{"year":96,"count":97},2025,58,{"year":67,"count":99},74,[101,104,107,109,112,114,117,119,121,124,126,128,130,132,134,136,139,141,143,145,147,149,151,153,155],{"name":102,"count":103},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",24,{"name":105,"count":106},"Centre National de la Recherche Scientifique CNRS",16,{"name":108,"count":62},"University of Cambridge",{"name":110,"count":111},"Institut National de la Sante Et de la Recherche Medicale",6,{"name":113,"count":111},"Kobenhavns Universitet",{"name":115,"count":116},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",5,{"name":118,"count":116},"Stichting Radboud Universiteit",{"name":120,"count":116},"Universitetet I Oslo",{"name":122,"count":123},"Commissariat A L Energie Atomique Et Aux Energies Alternatives",4,{"name":125,"count":123},"Forschungszentrum Julich Gmbh",{"name":127,"count":123},"Norges Teknisk-Naturvitenskapelige Universitet Ntnu",{"name":129,"count":123},"Technische Universiteit Delft",{"name":131,"count":123},"Tel Aviv University",{"name":133,"count":123},"Universitat Wien",{"name":135,"count":123},"University of Oxford",{"name":137,"count":138},"Aarhus Universitet",3,{"name":140,"count":138},"Ecole Polytechnique Federale de Lausanne",{"name":142,"count":138},"Eidgenoessische Technische Hochschule Zuerich",{"name":144,"count":138},"European Molecular Biology Laboratory",{"name":146,"count":138},"Gfz Helmholtz-Zentrum Fur Geoforschung",{"name":148,"count":138},"Humboldt-Universitaet Zu Berlin",{"name":150,"count":138},"Imperial College of Science Technology and Medicine",{"name":152,"count":138},"King's College London",{"name":154,"count":138},"Rheinische Friedrich-Wilhelms-Universitat Bonn",{"name":156,"count":138},"Universite Catholique de Louvain",[158,160,163,166,167,168,170,172,175,177,179,182,184,187,189,191,193,195,197,198,200,203,205,207,209],{"name":20,"count":159},82,{"name":161,"count":162},"FR",43,{"name":164,"count":165},"UK",29,{"name":48,"count":81},{"name":27,"count":103},{"name":12,"count":169},18,{"name":171,"count":169},"IT",{"name":173,"count":174},"DK",14,{"name":176,"count":174},"NO",{"name":41,"count":178},12,{"name":180,"count":181},"SE",10,{"name":183,"count":62},"IL",{"name":185,"count":186},"BE",7,{"name":188,"count":123},"GB",{"name":190,"count":138},"CZ",{"name":192,"count":138},"FI",{"name":194,"count":138},"HU",{"name":196,"count":138},"IE",{"name":34,"count":76},{"name":199,"count":76},"PL",{"name":201,"count":202},"CN",1,{"name":204,"count":202},"CY",{"name":206,"count":202},"EL",{"name":208,"count":202},"IN",{"name":210,"count":202},"LU"]