[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-msca-postdoctoral-fellowship-2006":3,"awarded-stats-msca-postdoctoral-fellowship":1162},{"awarded":4,"total":1161},[5,16,22,28,35,41,48,54,61,68,74,80,86,92,98,105,110,116,122,128,134,140,146,151,157,163,169,176,182,188,193,199,205,212,219,225,231,237,242,249,255,261,268,274,280,286,292,298,304,310,316,322,328,335,342,348,354,360,367,372,378,384,391,397,403,409,415,419,423,430,436,442,447,453,459,465,470,476,482,488,494,499,505,510,515,521,527,532,538,542,548,554,560,566,572,577,583,589,595,600,606,612,618,624,630,636,642,647,653,659,664,670,675,681,686,692,697,703,708,715,720,726,731,736,740,745,750,755,760,766,770,776,781,787,792,797,802,808,813,817,822,828,833,839,845,851,857,862,868,873,879,885,891,897,903,908,913,917,923,928,934,940,945,951,958,964,969,974,980,986,992,998,1004,1010,1015,1020,1026,1032,1036,1042,1048,1054,1061,1067,1072,1078,1083,1089,1095,1102,1107,1112,1118,1123,1129,1135,1139,1144,1150,1156],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-marie-skłodowska-curie-actions-award-21999","Marie Skłodowska-Curie Actions","MSCA Postdoctoral Fellowship","Physics Prospects at ALICEat LHC",null,"THE UNIVERSITY OF BIRMINGHAM","UK",2006,"€220,141","The ALICE experiment is a highly complex project involving about 1000 physicists from around the world. Both India and the United Kingdom are involved in it. The main aim of the project is to study the properties of the Quark-Gluon Plasma (QGP), a new form of matter which exists at extremely high energy densities. In ALICE, this will be achieved by colliding lead ions together in order to form tiny fireballs with temperatures of up to one million times that of the centre of the Sun.The main purp",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":12,"year":13,"amount":20,"abstract":21},"cordis-marie-skłodowska-curie-actions-award-24118","Control of proliferation and cell shape in Drosophila","MEDICAL RESEARCH COUNCIL","€159,613","How the size and form of an organism are controlled are two fundamental questions in developmental biology. The imaginal eye disc of Drosophila melanogaster provides an excellent model tissue to analyse both of these phenomena at the same time. This project has two goals. First, to analyse how the intercellular signals that drive eye development integrate to regulate proliferation. Second, to use a similar approach to elucidating how cell shape is regulated by signals. The particular development",{"id":23,"funder":7,"programme":8,"title":24,"piName":10,"institution":25,"country":12,"year":13,"amount":26,"abstract":27},"cordis-marie-skłodowska-curie-actions-award-7477","Combinatorial knot theory","THE UNIVERSITY OF LIVERPOOL","€141,674","The aim is to study curves and surfaces in 3-space, using discrete combinatorial data including braid and polygonal descriptions of curves and graphs. Polygonal descriptions will be used to capture features of curves and surfaces, which have a small number of extreme points measured in all spatial directions. Building on his previous successful visit to Liverpool under the INTAS scheme, recent methods of 3-page presentations for curves and graphs, familiar to the fellow, will be explored further",{"id":29,"funder":7,"programme":8,"title":30,"piName":10,"institution":31,"country":32,"year":13,"amount":33,"abstract":34},"cordis-marie-skłodowska-curie-actions-award-515055","European security and defence policy and the emergence of a shared normative self-understanding","EUROPEAN UNIVERSITY INSTITUTE","IT","€136,376","The European Union is moving towards a closer political union and envisions future projects of epochal dimensions. Among these projects are the Common Security and Foreign Policy and the European Security and Defence Policy (CSFP\u002FESDP). But these policy fields are very likely to interfere with national sovereignty and traditions. That is why some people hold that without shared values European governance is condemned to be ineffective, chaotic and irresponsible: Europe doesn't speak with one voi",{"id":36,"funder":7,"programme":8,"title":37,"piName":10,"institution":38,"country":12,"year":13,"amount":39,"abstract":40},"cordis-marie-skłodowska-curie-actions-award-25239","Pattern-based Architectures for Service Interaction","UNIVERSITY COLLEGE LONDON","€161,428","The research-training project PARIS is placed in the multi-disciplinary context of distributed information systems technology for virtual organisations and targets combined aspects of software engineering methodology and distributed middleware technology. In virtual organisations, business processes are decomposed w.r.t. core competencies of its partner organisations.These assets are continually re-integrated w.r.t. changing requirements of customers and markets. Each such constellation implies ",{"id":42,"funder":7,"programme":8,"title":43,"piName":10,"institution":44,"country":45,"year":13,"amount":46,"abstract":47},"cordis-marie-skłodowska-curie-actions-award-40294","Metamorphosis of a symmetrical [3]-catenane","UNIVERSITé LOUIS PASTEUR","FR","€155,383","Metal ions can play unprecedented role in function of mechanically linked molecules such as rotaxanes or catenanes. Due to a metal ion, a molecular system can respond to external stimulus (electrochemical process, variation of pH est.) with movement of the component parts that is essential property of molecular machines.Aims of this project are development of novel three fold symmetrcal [3]-catenane with three mechanically interlocked rings possessing two different coordination sites in each rin",{"id":49,"funder":7,"programme":8,"title":50,"piName":10,"institution":51,"country":45,"year":13,"amount":52,"abstract":53},"cordis-marie-skłodowska-curie-actions-award-40267","Non-regular Weak KAM Theory","ECOLE NORMALE SUPERIEURE DE LYON","€142,299","The aim of the project NONREGWKAM consists in enlightening weak KAM Theory and Lagrangian dynamics from a new point of view that is directed to point out and exploit fundamental interactions of this theory with different problems coming from the Calculus o f Variations and PDEs which are naturally posed in a non-smooth setting.It is possible to summarize the approach that will be employed in the following steps:- To generalize the dynamical approach and extend the results of weak KAM Theory to t",{"id":55,"funder":7,"programme":8,"title":56,"piName":10,"institution":57,"country":58,"year":13,"amount":59,"abstract":60},"cordis-marie-skłodowska-curie-actions-award-24471","Advanced Chemistry in Lean Low Emission combustor Simulations.","ROLLS-ROYCE DEUTSCHLAND LTD AND CO KG","DE","€148,588","The objective of the proposed Marie Curie Intra-European Fellowship is to provide the researcher with training and research experience in the field of combustion modelling and Large Eddy Simulations. He will be working in a multidisciplinary multilingual international research team and obtain the required training to work as a full member of the research team. The researcher has proven his academic capabilities through the excellent work, which he has achieved during this Ph.D. research. This Ph",{"id":62,"funder":7,"programme":8,"title":63,"piName":10,"institution":64,"country":65,"year":13,"amount":66,"abstract":67},"cordis-marie-skłodowska-curie-actions-award-8914","The effects of breeding synchrony on avian reproductive strategies","RIJKSUNIVERSITEIT GRONINGEN","NL","€214,837","The discovery that birds commonly mate with individuals other than their own social partner, resulting in extra-pair paternity (EPP), has been described as the most important advance in the field of avian mating systems in the last thirty years. However, w e still have only a rudimentary understanding of the function of these extra-pair copulations (EPC), or the reason why the frequency of EPP varies so dramatically both between and within different species.One of the leading factors proposed to",{"id":69,"funder":7,"programme":8,"title":70,"piName":10,"institution":71,"country":45,"year":13,"amount":72,"abstract":73},"cordis-marie-skłodowska-curie-actions-award-39750","Development and application of electronic quantum Monte Carlo methods to improve density functional theory","UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6","€161,529","The present project concerns developments in computational electronic-structure theory, which are relevant to theoretical chemistry and materials science.It aims at allowing the applicant to pursue the work he began to improve the multi-determinantal density functional theory (DFT) method proposed by Dr. Andreas Savin and coworkers, which, by combining a long-range conventional wave function calculation with a short-range density functional approximation, has the potential of curing the main sho",{"id":75,"funder":7,"programme":8,"title":76,"piName":10,"institution":77,"country":58,"year":13,"amount":78,"abstract":79},"cordis-marie-skłodowska-curie-actions-award-21402","Quantum groups, Hall algebras and positive Schur algebras","UNIVERSITAET ZU KOELN","€147,991","This project will investigate the structure and representation theory of quantized enveloping algebras of finite dimensional semisimple complex Lie algebras and of affine Kac-Moody algebras, and of other algebras closely related to them: Hall algebras and (quantized) Schur algebras. The project's starting point is a construction, due to Beilinson, Lusztig and MacPherson, of an epimorphism from a type A quantum group onto a Schur algebra. So far, this construction has been limited to type A (with",{"id":81,"funder":7,"programme":8,"title":82,"piName":10,"institution":83,"country":12,"year":13,"amount":84,"abstract":85},"cordis-marie-skłodowska-curie-actions-award-515391","Dynamics of non-expensive maps: Theory and Applications to discrete event systems","THE UNIVERSITY OF WARWICK","€129,850","The objective of the research project is to investigate the dynamical behaviour of certain discrete event systems. Discrete event systems are a useful abstraction to analyse the performance of certain man-made systems including, digital circuits, communication networks, and manufacturing systems. In practice designers of these systems are faced with a number of dynamical questions: What is the long-term behaviour of the system? What are its stability properties? How fast does it operate? To answ",{"id":87,"funder":7,"programme":8,"title":88,"piName":10,"institution":89,"country":12,"year":13,"amount":90,"abstract":91},"cordis-marie-skłodowska-curie-actions-award-20351","New methodologies to synthetise unnatural nucleosides, known and putative antiproliferative agents","QUEEN'S UNIVERSITY BELFAST","€874,196","Dr Migaud and colleagues, all academic medicinal synthetic chemists at Queen's University Belfast (Northern Ireland, academic partner), in collaboration with GlaxoSmithKline (Stevenage, UK, Industrial partner via Dr McDonald) seek financial support to host an Early Stage Research Training programme for four post-graduate researchers (36 months each) who would pursue a PhD training programme in Organic and Medicinal Chemistry at QUB\u002FGSK and for the equivalent of four visiting EST fellows (12 mont",{"id":93,"funder":7,"programme":8,"title":94,"piName":10,"institution":95,"country":65,"year":13,"amount":96,"abstract":97},"cordis-marie-skłodowska-curie-actions-award-25726","Mediation of Emotions: Sentimental Citizens, Communities of Feeling and Emotional Public Sphere","UNIVERSITEIT VAN AMSTERDAM","€198,416","Emotions",{"id":99,"funder":7,"programme":8,"title":100,"piName":10,"institution":101,"country":102,"year":13,"amount":103,"abstract":104},"cordis-marie-skłodowska-curie-actions-award-25316","Non Abelian Reidemeister Torsion","CENTRE DE RECERCA MATEMATICA","ES","€129,644","The research project is divided into several parts and includes scientific collaborations with A. Cattaneo (Zurich), R. Kashaev (Geneva), I. Korepanov (Chelyabinsk), and J. Porti (Barcelona).- Connections between the volume conjecture and the volume form Rinat Kashaev and I are studying the connections between the non-abelian Reidemeister torsion for knot exteriors and the volume conjecture. The volume conjecture is currently a very active field of research and combines quantum invariants with h",{"id":106,"funder":7,"programme":8,"title":107,"piName":10,"institution":101,"country":102,"year":13,"amount":108,"abstract":109},"cordis-marie-skłodowska-curie-actions-award-515339","Characterisations of geometric groups","€130,211","Results involving all finitely generated groups are often of very little interest, and therefore combinatorial group theory concentrates on particular classes of groups. Hyperbolic groups form one of the classes that offer an extremely satisfactory compromise between interest and generality, as one can prove very precise structural results for such groups. In our project we propose to work on relatively hyperbolic groups, which are a generalisation of hyperbolic groups, and on some other questio",{"id":111,"funder":7,"programme":8,"title":112,"piName":10,"institution":113,"country":102,"year":13,"amount":114,"abstract":115},"cordis-marie-skłodowska-curie-actions-award-38924","Black holes in higher dimensional gravity theories","UNIVERSITAT DE BARCELONA","€133,045","In this proposal we will explore the physics of black holes in a higher dimensional background. Recently, this arena introduced unexpected ingredients to the physics of black holes. Both in the framework of vacuum Einstein theory and in its extension to include the super-gravity fields of low energy string theory, there is a higher variety of black hole solutions: they can be extended objects, and they can have a non-spherical topology like the black ring solutions.These black ring solutions vio",{"id":117,"funder":7,"programme":8,"title":118,"piName":10,"institution":119,"country":12,"year":13,"amount":120,"abstract":121},"cordis-marie-skłodowska-curie-actions-award-24713","Hydrogeophysics: Joint inversion of self-potential and electrical resistivity data to characterize subsurface flow","LANCASTER UNIVERSITY","€159,046","An alternative approach to characterize groundwater flow is to use minimally invasive, rapid and cost-effective geophysical methods in complement to `classical hydraulic and geochemical methods. The Electrical Resistivity Tomography (ERT) and the Self-Pote ntial (SP) methods offer such a possibility because these methods are sensitive to pore water saturation and groundwater flow. The ERT is an active method used to obtain the distribution of the electrical resistivity in the subsoil. The SP met",{"id":123,"funder":7,"programme":8,"title":124,"piName":10,"institution":125,"country":12,"year":13,"amount":126,"abstract":127},"cordis-marie-skłodowska-curie-actions-award-39812","Electron self trapping in supercritical CO2","THE UNIVERSITY OF NOTTINGHAM","€153,376","The development and utilization of new technologies using supercritical carbon dioxide (sc-CO2) makes them quite attractive their using in new nano-electronic devices and understanding of novel mechanisms for drug transfer in human organism.The main purpose of this proposal is the theoretical study molecular complex formation in sc-CO2 solutions induced by their interaction with low energy electrons that leads to weak electron localization. As a main tool for the theoretical treatment of these s",{"id":129,"funder":7,"programme":8,"title":130,"piName":10,"institution":131,"country":58,"year":13,"amount":132,"abstract":133},"cordis-marie-skłodowska-curie-actions-award-39359","Emergent semantics in personalized multimedia content","KURATORIUM OFFIS E.V.","€119,772","Authoring of personalized multimedia content can be considered as a process consisting of selecting, composing, and assembling media elements into coherent multimedia presentations that meet the user's or user group's preferences, interests, current situation, and environment. In the approaches we find today, media items and semantically rich metadata information are used for the selection and composition task. However, most valuable semantics for the media elements and the resulting multimedia ",{"id":135,"funder":7,"programme":8,"title":136,"piName":10,"institution":137,"country":102,"year":13,"amount":138,"abstract":139},"cordis-marie-skłodowska-curie-actions-award-22242","The role of connectivity in shaping sensory processing and memory in network models of the cerebral cortex","UNIVERSITAT POMPEU FABRA","€135,026","Experimental data indicate that the cerebral cortex is spatially structured. Connections between neurons are not entirely random but rather seem to follow certain rules, leading to well-defined patterns of connectivity. These patterns shape the manner of feedback that each neuron receives and to which it, in turn, contributes. The connectivity thus strongly influences the spatio-temporal dynamics that arise in the cortex and, in particular, the way in which it processes sensory input.The role of",{"id":141,"funder":7,"programme":8,"title":142,"piName":10,"institution":143,"country":12,"year":13,"amount":144,"abstract":145},"cordis-marie-skłodowska-curie-actions-award-25707","Diffusive trace metals in Arctic Ocean surface waters","THE CHANCELLORS, MASTERS, AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€159,614","Primary production in the ocean depend upon availability of the major nutrients carbon, nitrogen, phosphorus, and silicon. However, a number of essential micronutrients (e.g. Fe, Mo, Co, Ni, Cu, Zn, and Cd) with atomic mass >50 may also control growth of phytoplankton. Therefore, bioavailability and speciation for trace metal is important to study. Determination of chemical forms (species) in which bio-available micronutrients are present in seawater is a challenge for chemical oceanographers. A",{"id":147,"funder":7,"programme":8,"title":148,"piName":10,"institution":113,"country":102,"year":13,"amount":149,"abstract":150},"cordis-marie-skłodowska-curie-actions-award-21379","B decays and new effective field theories","€317,850","The experimental results provided by the existing B-factories (Babar, Belle) and by then ones that will be built in Europe (LHC) will urge a deeper theoretical comprehension. The target of the proposal is 1- to achieve a comprehension of B-meson decays dev eloping new effective field theories, 2- to provide a stringent test of the CKM matrix and so reveal eventual New Physics contributions. The two targets are related one another as new approaches are necessary in order to achieve a deeper under",{"id":152,"funder":7,"programme":8,"title":153,"piName":10,"institution":154,"country":102,"year":13,"amount":155,"abstract":156},"cordis-marie-skłodowska-curie-actions-award-25154","Molecular control of brain regionalization and neural cell diferentaition by planar inductions","UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE","€195,172","This proposal deals with the role of Fgf8 in regulating regionalisation of the vertebrate brain during embryogenesis and its potential role as a regulator of function in the mature brain. In embryos Fgf8 is a primary signal involved in brain regionalisation and pattern formation. Localised Fgf8 expression in co-operation with Wnt, Bmp and Shh signals promotes localised cell fate determination and long range patterning of surrounding areas. We propose to study the role of FGF8 dependent Ca2+ sign",{"id":158,"funder":7,"programme":8,"title":159,"piName":10,"institution":160,"country":58,"year":13,"amount":161,"abstract":162},"cordis-marie-skłodowska-curie-actions-award-39706","Search for steady and transient sources of high-energy cosmic neutrinos with IceCube and ANTARES","FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG","€249,752","With his project, the candidate proposes to utilise the currently most sensitive neutrino telescopes in the Southern and Northern hemispheres, IceCube and ANTARES, to search for the sources of high-energy cosmic neutrinos.Their identification and analysis will establish a break-through in understanding the production and acceleration mechanisms of high-energy cosmic rays - currently one of the major open questions in astroparticle physics The candidate applies for an outgoing Marie Curie Fellows",{"id":164,"funder":7,"programme":8,"title":165,"piName":10,"institution":166,"country":12,"year":13,"amount":167,"abstract":168},"cordis-marie-skłodowska-curie-actions-award-42409","Snowball Earth: Equatorial glaciations in the Neoproterozoic","THE UNIVERSITY OF EDINBURGH","€1,997,387","Evidence from the Neoproterozoic geological period suggests that at least three times in the Earth's history, there were extreme variations in global climate which resulted in marine glaciers forming in equatorial latitudes, which in turn may have provided the trigger for the Cambrian explosion of multi-cellular life forms.The most popular model to explain this climatic phenomenon is the Snowball Earth hypothesis which necessitates dramatic and catastrophic changes in global climatic, hydrologic",{"id":170,"funder":7,"programme":8,"title":171,"piName":10,"institution":172,"country":173,"year":13,"amount":174,"abstract":175},"cordis-marie-skłodowska-curie-actions-award-24483","Theory and application of definable forcing","THE HEBREW UNIVERSITY OF JERUSALEM","IL","€164,315","Set theory offers very general and powerful methods to prove mathematical theorems. In some instances, set theoretic methods actually prove that certain mathematical questions are undecidable, i.e. neither provable nor refutable. A famous example is the Continuum Hypothesis. Usually such independence proofs use the method of forcing. Forcing has been developed into a deep and sophisticated theory. Especially important are iterations of forcing constructions. The most common iterations are finite",{"id":177,"funder":7,"programme":8,"title":178,"piName":10,"institution":179,"country":12,"year":13,"amount":180,"abstract":181},"cordis-marie-skłodowska-curie-actions-award-24627","Numerical investigation of the finite-amplitude solutions in cylindrical pipe flow","UNIVERSITY OF BRISTOL","€151,675","Pressure-driven fluid flow through a circular pipe has for a long time been the intriguing stability problem in fluid mechanics. Ever since the original experiments of Reynolds (1883), it has been known that the steady laminar flow observed at low flow rates can undergo transition to turbulence when disturbed sufficiently strongly at high enough flow rates. Despite numerous numerical and theoretical investigations, an understanding of the transition mechanism remains far from complete. Very rece",{"id":183,"funder":7,"programme":8,"title":184,"piName":10,"institution":185,"country":12,"year":13,"amount":186,"abstract":187},"cordis-marie-skłodowska-curie-actions-award-21992","Integration of Cruciferae genetic and genomic maps","JOHN INNES CENTRE","€169,365","Oilseed rape (Brassica napus) is the most important Brassica crop in European agriculture, with both food and industrial applications for the oil it produces. Although the Brassica are the group of crops most closely related to Arabidopsis thaliana, their much greater genome complexity is proving a substantial barrier to the transition to Brassica, for crop improvement, of biological knowledge gain in Arabidopsis.   The international research community has therefore launched a Multinational Bras",{"id":189,"funder":7,"programme":8,"title":190,"piName":10,"institution":191,"country":12,"year":13,"amount":186,"abstract":192},"cordis-marie-skłodowska-curie-actions-award-22250","Nanomist for fire suppression and explosion mitigation","KINGSTON UNIVERSITY","NanoMist is the trade name for the proprietary process technology of producing, scaling, transporting, and delivering nano- to micron-sized droplets, particles and mists. These technologies can be used to produce ultra fine water mist systems for fire suppression and explosion control and serve as an environmental friendly replacement of Halon 1301. The proposal aims to carry out numerical investigations of the dynamic âStwo-way❠interaction of ultra fine water mist droplets with flames in the ",{"id":194,"funder":7,"programme":8,"title":195,"piName":10,"institution":196,"country":58,"year":13,"amount":197,"abstract":198},"cordis-marie-skłodowska-curie-actions-award-25720","Modelling Ice Sheet Evolution and Sea-Level Change to Investigate Rapid and Early Antarctic Deglaciation","ALFRED-WEGENER-INSTITUT FUER POLAR- UND MEERESFORSCHUNG","€150,260","The climate system has undergone several rapid and large magnitude events in the period from last glacial maximum (LGM) to present day. Two of these key events occur between 15 and 14 cal. kyr BP: the warming of the northern Atlantic region (the Bolling-A llerod warm interval) and a rapid sea-level rise of around 25m in 1 kyr, meltwater pulse IA (mwp-IA). Recent sea-level modelling studies show that equatorial data are more compatible with a melt-source for mwp-IA that includes a dominant Antarc",{"id":200,"funder":7,"programme":8,"title":201,"piName":10,"institution":202,"country":102,"year":13,"amount":203,"abstract":204},"cordis-marie-skłodowska-curie-actions-award-25116","Non linear Galois theory for continuous and discrete dynamical systems","UNIVERSITAT AUTONOMA DE BARCELONA","€136,726","The research proposal concerns nonlinear Galois theory and applications to study of continuous and discrete dynamical systems. Recently, two theories were proposed by H. Umemura (with an algebraic and arithmetical flavour) and B.Malgrange (with a geometrical and dynamical flavour).   The purpose of this proposal is to:  - develop the theory of Lie groupoid using fruitful interrelations between the formal theory of partial differential equations and differential algebra,  - apply Galois theory to",{"id":206,"funder":7,"programme":8,"title":207,"piName":10,"institution":208,"country":209,"year":13,"amount":210,"abstract":211},"cordis-marie-skłodowska-curie-actions-award-41818","Modelling pH-Dependence in rational drug design","UNIVERSITY OF COPENHAGEN","DK","€79,600","Rational drug design relies on accurately and efficiently estimating the binding energies of drug candidates to a protein. There is now experimental evidence that the protonation states (and, hence, the charges) of functional groups in both the protein and ligand can change upon binding, and significantly alter the binding energy. However, this phenomenon is not included in any rational drug design studies.My goals are to:(1) extend our current protein pKa prediction methodology (PROPKA) to incl",{"id":213,"funder":7,"programme":8,"title":214,"piName":10,"institution":215,"country":216,"year":13,"amount":217,"abstract":218},"cordis-marie-skłodowska-curie-actions-award-20269","Acceleration of glacier wastage and sea level rise","STOCKHOLMS UNIVERSITET","SE","€226,057","GLASEAL will be a multidisciplinary study at Stockholm University (Department of Geography and Quaternary Geology, Tarfala Research Station). The project includes global components, such as change in volume of glaciers outside the Antarctic and Greenland ice sheets, glacier contribution to sea level and the relation to global geodesy.Glacier contribution to sea level rise has accelerated implying serious environmental, social and economic impacts. This has a broad impact on several global proces",{"id":220,"funder":7,"programme":8,"title":221,"piName":10,"institution":222,"country":45,"year":13,"amount":223,"abstract":224},"cordis-marie-skłodowska-curie-actions-award-40751","On some open problems about curves in Algebraic geometry","ECOLE POLYTECHNIQUE","€159,315","After four years of full-time research during my PhD Thesis, a partnership with the French Ecole Polytechnique and the Indian Tata institute of Fundamental Research represents the best opportunity to widen my mathematical expertise as well as to establish a strong relationship with the top ranked researchers (especially in my field of interest) in a country that is called to play a major role in the beginning century.On the one hand, my Thesis work raised several questions of interest. One the o",{"id":226,"funder":7,"programme":8,"title":227,"piName":10,"institution":228,"country":45,"year":13,"amount":229,"abstract":230},"cordis-marie-skłodowska-curie-actions-award-24513","Geometry and stability of singularities in integrable systems","LABORATOIRE EMILE PICARD - UNIVERSITE PAUL SABATIER","€142,866","This project is mainly concerned with the geometry underlying integrable dynamical systems both Hamiltonian and non-hamiltonian. The best well-known examples of integrable systems are probably completely integrable Hamiltonian systems. Hamiltonian systems arise naturally in mechanical systems. For instance the motion of celestial bodies or Shrondinger equation are examples of these phenomena. Non-Hamiltonian systems arise in dynamical systems with non-holonomic constraints. Completely integrable",{"id":232,"funder":7,"programme":8,"title":233,"piName":10,"institution":234,"country":58,"year":13,"amount":235,"abstract":236},"cordis-marie-skłodowska-curie-actions-award-21591","Phytochemical and Pharmacological Study of Plants Used in Traditional Medicine in Cameroon","BIELEFELD UNIVERSITY","€158,197","Natural product chemistry continues to provide a rich source of pharmacologically active compounds and therefore extensively contributes to the chemical repertoire of medicinal chemistry. The development of new drugs still very much relies on the utilisation of physiologically active natural products. The proposed project focuses on the isolation, structural characterization, and determination of the biological activity of secondary metabolites produced by plants of Psorospermum species.  In Cam",{"id":238,"funder":7,"programme":8,"title":239,"piName":10,"institution":179,"country":12,"year":13,"amount":240,"abstract":241},"cordis-marie-skłodowska-curie-actions-award-39616","Ascent and Transfer of Magma","€158,480","We propose to study the petrological and isotopic data and their variabilities for given volcanoes using different theoretical models.This fundamental work will be a basis to determine the critical timesclaes and volumes of magma storage and transfer.The final aim is to help to determine the existence of shallow reservoirs of magma in the crust, an important question for the management of risk in volcanology",{"id":243,"funder":7,"programme":8,"title":244,"piName":10,"institution":245,"country":246,"year":13,"amount":247,"abstract":248},"cordis-marie-skłodowska-curie-actions-award-22021","Spontaneous Neural Activity and Human Auditory Perception","HELSINKI UNIVERSITY OF TECHNOLOGY","FI","€86,865","Humans are remarkably good at perceiving relevant sounds in a variety of background conditions. My research plan is focused on understanding how the neural systems supporting human auditory perception dynamically reorganize to optimize for efficient proc essing of sounds in various behavioral contexts. Specifically, I would like to study the rapid attentional mechanisms involved in auditory classification of tones and tone sweeps. I propose to address these questions using combined electroenceph",{"id":250,"funder":7,"programme":8,"title":251,"piName":10,"institution":252,"country":32,"year":13,"amount":253,"abstract":254},"cordis-marie-skłodowska-curie-actions-award-21702","Questions of decidability and definability in the Enumeration degrees","UNIVERSITÀ DEGLI STUDI DI SIENA","€145,616","We propose to ascertain if there is an effective procedure that determines the validity of an arbitrary first order $\\forall\\exists$-sentence in the upper semi-lattice of the $\\Sigma^0_2$ enumeration degrees. It is known that the $\\forall$-fragment of the first order theory of the $\\Sigma^0_2$ enumeration degrees is decidable. Slaman and Woodin (1996) proved that first order theory of the $\\Sigma^0_2$ enumeration degrees is un-decidable and more recently, Kent (unpublished) proved that the $\\for",{"id":256,"funder":7,"programme":8,"title":257,"piName":10,"institution":258,"country":65,"year":13,"amount":259,"abstract":260},"cordis-marie-skłodowska-curie-actions-award-8307","Biogeomorphodynamic model of Estuaries for the analysis of effects of human interference","UNIVERSITY OF TWENTE","€250,417","Estuaries are important for economy and nature. Due to the relatively calm conditions where land meets the water, they are good locations for harbours and are safe havens and feeding grounds for wildlife. These qualities collide in the Western Scheldt. Dredging is required to enable navigation to Antwerp Harbour, but it endangers the stability of the shoals that are important to ecology. The interactions of the bed and the water flow over it shape the estuaries. The bed determines the flow of th",{"id":262,"funder":7,"programme":8,"title":263,"piName":10,"institution":264,"country":265,"year":13,"amount":266,"abstract":267},"cordis-marie-skłodowska-curie-actions-award-41816","A study of QoS for VoIP in 802.11 Mesh Networks","NATIONAL UNIVERSITY OF IRELAND, DUBLIN","IE","€147,074","The objective of the proposed work is to investigate a terminal-oriented approach to realise VoIP in a mesh network context. More specifically, the objective is to investigate the use of the Datagram Congestion Control Protocol in conjunction with an adaptive VoIP codec to determine what level of performance can be attained in an 802.11-based mesh network. A terminal-based approach is chosen, as it can be quite difficult for any network device to have sufficient knowledge to make appropriate dec",{"id":269,"funder":7,"programme":8,"title":270,"piName":10,"institution":271,"country":12,"year":13,"amount":272,"abstract":273},"cordis-marie-skłodowska-curie-actions-award-41026","The neural bases of object knowledge - a neurocognitive investigation","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€168,232","Conceptual representations are at the heart of mental life, involved in every aspect of our cognitive functioning; they allow us to see the world as a structured environment populated by meaningful objects rather than an array of raw perceptual information, to imagine and reason about these objects when they are no longer present, to communicate with others about them, and to interact with them in appropriate ways. Recent advances in brain imaging techniques allow us to revisit this classic issu",{"id":275,"funder":7,"programme":8,"title":276,"piName":10,"institution":277,"country":102,"year":13,"amount":278,"abstract":279},"cordis-marie-skłodowska-curie-actions-award-23865","Colouring Geometric Graphs","UNIVERSITAT POLITECNICA DE CATALUNYA","€190,637","Graphs are ubiquitous mathematical structures that model relational information such as computer networks, biochemical pathways, transportation networks, computer flowcharts, social networks, etc. More formally, a `graph' consists of a set of `vertices', and a set of `edges' each of which connects two vertices.Often a geometric representation of a graph is desirable. For example, a programmer is likely to better understand a computer program if a visually appealing drawing is on hand that repres",{"id":281,"funder":7,"programme":8,"title":282,"piName":10,"institution":283,"country":102,"year":13,"amount":284,"abstract":285},"cordis-marie-skłodowska-curie-actions-award-21873","Very long Baseline Interferometric astrometry of SiO masers around AGB stars to track the mass loss processes","FUNDACION GENERAL DE LA UNIVERSIDAD DE ALCALA - INSTITUTO GEOGRAFICO NACIONAL","€181,852","The Observatorio Astronómico Nacional (OAN) is building a new 40 meter state of the art VLBI antenna, at Yebes, Spain. We will use my experience to integrate this into the European astronomical networks. We will then use its innovative optical system to develop the new calibration method of astrometric frequency phase transfer for spectral line VLBI'' for the general astronomical community. We will use this method to align SiO maser multi-transition observations to a common reference frame, and ",{"id":287,"funder":7,"programme":8,"title":288,"piName":10,"institution":289,"country":265,"year":13,"amount":290,"abstract":291},"cordis-marie-skłodowska-curie-actions-award-22184","No Longer Researching About Us Without Us","THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (HEREINAFTER CALLED TCD)","€222,649","As a research project 'Nothing about us without us' is based on the values of belonging, equality, and respect. These values are at the core of the concept of equal opportunity and full participation of people with learning disabilities in their quest for inclusive lives. The project responds to the criticism made by members of disabled groups that in the past research has succeeded in doing things to people with disabilities rather than including them in the setting of the research agenda.This ",{"id":293,"funder":7,"programme":8,"title":294,"piName":10,"institution":295,"country":45,"year":13,"amount":296,"abstract":297},"cordis-marie-skłodowska-curie-actions-award-24848","Archaeological soil micromorphology of early prehistoric and ethnographic sites","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE","€153,072","We propose to apply the technique of archaeological soil micromorphology to a selected group of European and Asian prehistoric sites, and of African ethnographic sites, with the goal of reconstructing original contexts of hunter-gatherer activities that w ill lead us to approach the lifestyles and behaviour of our prehistoric ancestors.The project proposed focuses on the Early Palaeolithic, a crucial timeframe that encloses the roots of human evolution and the earliest dispersals that led to the",{"id":299,"funder":7,"programme":8,"title":300,"piName":10,"institution":301,"country":65,"year":13,"amount":302,"abstract":303},"cordis-marie-skłodowska-curie-actions-award-21986","Rethinking Secularity in the light of Contemporary Religious Revival: Female Religious Agency","UTRECHT UNIVERSITY - WOMEN'S STUDIES","€203,732","The research project, embedded within the interdisciplinary field of Women's Studies, seeks to account for the engagement of women in contemporary religious (fundamentalist) revival movements, against the background of following observations: (1) an increase in religious identifications and subsequent challenges to the secular status quo, (2) the great participation of women in this religious revival, and (3) an emphasis within such movements on moral issues of family, sexuality and kinship, inc",{"id":305,"funder":7,"programme":8,"title":306,"piName":10,"institution":307,"country":65,"year":13,"amount":308,"abstract":309},"cordis-marie-skłodowska-curie-actions-award-41115","Financial modelling with multivariate local jump processes","TECHNISCHE UNIVERSITEIT EINDHOVEN","€142,472","The proposed research project aims to develop a specific class of multivariate local stochastic models with jumps, called multivariate local Levy models. The resulting multivariate models can be applied to the problem of pricing financial derivatives written on a portfolio of several underlying assets, for example, basket options and Collateralised Debt Obligations, where the dependence between the assets in the underlying portfolio is of great importance. To develop stochastic models that can d",{"id":311,"funder":7,"programme":8,"title":312,"piName":10,"institution":313,"country":58,"year":13,"amount":314,"abstract":315},"cordis-marie-skłodowska-curie-actions-award-41076","Mixed Hodge realization of triangulated mixed motives and comparison of triangulated categories of motives","UNIVERSITÄT DUISBURG-ESSEN","€71,742","In the 1960s Grothendieck made conjectures as to the existence of a universal framework for cohomology of algebraic varieties called the category of mixed motives. During the 1980's the conjectural formalism was enriched by conjectures of Deligne, Beilinson, Bloch and others. In the 1990's V. Voevodsky, M. Levine and M. Hanamura have given several constructions of triangulated categories that have many of the expected properties of the derived category of mixed motives. As part of Grothendieck a",{"id":317,"funder":7,"programme":8,"title":318,"piName":10,"institution":319,"country":58,"year":13,"amount":320,"abstract":321},"cordis-marie-skłodowska-curie-actions-award-39905","Analysis of the troposphere composition changes over Russia","MAX-PLANCK SOCIETY FOR THE ADVANCEMENT OF SCIENCES","€211,253","The main aim of the project is to investigate the changes of the tropospheric composition over Russian midlatitudes. The project is based on the long-term measurements of the greenhouse and associated gases across Russia in train-based experiments TROICA.Unique equipment complex, extended route (of about 8500 km) across a continent and the period of campaign (since 1995 to nowadays) give a unique opportunity to investigate a complex interactions of key tropospheric species under different condit",{"id":323,"funder":7,"programme":8,"title":324,"piName":10,"institution":325,"country":45,"year":13,"amount":326,"abstract":327},"cordis-marie-skłodowska-curie-actions-award-41412","Lab-on-a-chip based analyzers for point-of-care monitoring of cancer therapy","ECOLE CENTRALE DE LYON","€161,621","The objective is to develop advanced disposable chips, for point-of-care multi-parametric analysis of protein cancer markers. It is important to note that monitoring of multiple markers is essential to improve the reliability and the specificity of the analysis.The complete analytical instruments will comprise of disposable chips and a control unit, with dimensions of a credit card and book respectively. The essential functional blocks needed for sample preparation and analysis will be developed",{"id":329,"funder":7,"programme":8,"title":330,"piName":10,"institution":331,"country":332,"year":13,"amount":333,"abstract":334},"cordis-marie-skłodowska-curie-actions-award-24660","Study of neutron star crust with solid state theory","UNIVERSITE LIBRE DE BRUXELLES","BE","€136,649","The inner neutron star crust, composed of a lattice of nuclei immersed in a neutron superfluid, plays an important role in our understanding of many observational issues, such as pulsar glitches, thermal emission and cooling or gravitational wave instabili ties. The growing number of data in the whole electromagnetic spectrum and the imminent rising of the gravitational wave astronomy urge the need for a deep theoretical study of the neutron star crust. This is even more so as a detailed analysi",{"id":336,"funder":7,"programme":8,"title":337,"piName":10,"institution":338,"country":339,"year":13,"amount":340,"abstract":341},"cordis-marie-skłodowska-curie-actions-award-42112","Links between Meridional Overturning Circulation and climate changes during the Holocene","UNIVERSITETET I BERGEN","NO","€148,483","The Meridional Overturning Circulation (MOC) is a major component of the meridional heat transfer in the North Atlantic Ocean. We have been able to demonstrate the possibility of reconstructing past drops in MOC during the major melt water surges of the la st deglaciation, using a new paleoceanographic proxy, the sedimentary 231Pa\u002F230Th ratio. These MOC drops were clearly associated with drastic coolings of the Northern Hemisphere high latitudes. Climate of the past few thousands years is signif",{"id":343,"funder":7,"programme":8,"title":344,"piName":10,"institution":345,"country":58,"year":13,"amount":346,"abstract":347},"cordis-marie-skłodowska-curie-actions-award-25007","When do injected dykes reach the surface to feed eruptions in a volcano? Field observations, numerical modelling, and hazard implications","GEORG-AUGUST-UNIVERSITAET GOETTINGEN STIFTUNG OEFFENTLICHEN RECHTS","€152,528","With more than 500 million people living near active volcanoes worldwide, including many million in EU, improved understanding of how volcanoes work is absolutely necessary so as to be able reduce volcanic risk. The understanding of hazard-related processes once an eruption has progressed much in recent decades.No similar progress has been made in understanding the physical processes that occur inside volcanoes during unrest periods, some of which are manifest in surface deformation, landslides,",{"id":349,"funder":7,"programme":8,"title":350,"piName":10,"institution":351,"country":45,"year":13,"amount":352,"abstract":353},"cordis-marie-skłodowska-curie-actions-award-41306","Scalable, flexible global illumination and natural lighting","INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE","€96,378","The creation of realistic computer graphics images involves complex computations of the interaction of light and surfaces. Global illumination algorithms compute physically based solutions but are slow by nature. For interactive rendering detached algorithms with specific approximations and simplifications are used to plausibly reproduce certain sub-sets of global illumination effects.  The goal of this project is to develop a scalable and flexible global illumination algorithm. Scalable relates",{"id":355,"funder":7,"programme":8,"title":356,"piName":10,"institution":357,"country":45,"year":13,"amount":358,"abstract":359},"cordis-marie-skłodowska-curie-actions-award-24273","Innate immune system of bdelloid rotifers","CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE-DELEGATION LANGUEDOC-ROUSSILLON","€160,487","Bdelloid rotifers are freshwater micro-invertebrates being the largest, oldest, most successful group of multicellular organisms reproducing asexually. The existence and success of bdelloids has been called and quot;an evolutionary scandal and quot; becau se all theories on the evolution of sex predict that bdelloids should be extinct. Their existence thus indicates that they must have evolved alternate means of achieving the advantages conferred by sexual reproduction. One of the advantages of ",{"id":361,"funder":7,"programme":8,"title":362,"piName":10,"institution":363,"country":364,"year":13,"amount":365,"abstract":366},"cordis-marie-skłodowska-curie-actions-award-41146","Amyloid fibril structures explored by solid-state NMR","EIDGENOSSICHE TECHNISCHE HOCHSCHULE, ZURICH","CH","€173,264","Amyloid fibrils are self-assembled filamentous structures associated with a wide variety of severely debilitating human pathologies like Alzheimers disease, type II diabetes and the transmissible spongiform encephalopathies. Despite the immense medical importance of amyloid fibrils, no atomic-resolution structures are available for these materials yet. The aim of the project is to determine the structure of the carboxy-terminal part of the prion protein HET-s in its fibrillar state using solid-s",{"id":368,"funder":7,"programme":8,"title":369,"piName":10,"institution":208,"country":209,"year":13,"amount":370,"abstract":371},"cordis-marie-skłodowska-curie-actions-award-41613","The Perplexity of Parasitism; Co-evolution between Cordyceps fungi and Carpenter ants","€190,108","The social insects are among the great achievements of organic evolution and their societies represent a major evolutionary transition in lifes move towards complexity. Consequently, insect societies have historically held a considerable interest for both biologists and lay people. One particularly interesting and rapidly developing field for evolutionary biologists is the interaction between social insects and their parasites. My proposal will be set within this field. I will use the parasite f",{"id":373,"funder":7,"programme":8,"title":374,"piName":10,"institution":375,"country":12,"year":13,"amount":376,"abstract":377},"cordis-marie-skłodowska-curie-actions-award-25349","Ankyrin-encoding genes in Wolbachia","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€168,798","Wolbachia is an intracellular bacterium capable of inducing various forms of the reproductive manipulation in a diversity of arthropods. The best characterized type of reproductive manipulation is cytoplasmic incompatibility (CI) which makes sperm from inf ected males unable to complete fertilization of eggs from uninfected females whereas eggs from infected females develop normally. At present the molecular basis for CI is not understood. Several genomes of CI-inducing Wolbachia are being seque",{"id":379,"funder":7,"programme":8,"title":380,"piName":10,"institution":381,"country":265,"year":13,"amount":382,"abstract":383},"cordis-marie-skłodowska-curie-actions-award-40326","Creation and use of trust in virtual communities through reputation Management","THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN.(HEREINAFTER CALLED TCD)","€154,206","The increasing size and complexity of computer systems today makes distributed and self-organizing systems an attractive proposition. This project examines how reputation management schemes can be used to monitor and manage these systems in a decentralized fashion.Reputation management is not a replacement of traditional security solutions and is instead a complementary strategy that works through establishing trust between members of a virtual community allowing them to collaborate so that they",{"id":385,"funder":7,"programme":8,"title":386,"piName":10,"institution":387,"country":388,"year":13,"amount":389,"abstract":390},"cordis-marie-skłodowska-curie-actions-award-22811","Randomised approximation with Frames","UNIVERSITY OF VIENNA","AT","€142,025","A frame is a family of vectors in a Hilbert space, which allows representation of arbitrary elements by (continuous) superposition. Important examples of frames appear in time-frequency analysis, wavelet analysis and sampling theory.We propose a new class of algorithms based on randomization for approximating elements (usually functions) with frames. The basic idea is to select randomly frame elements and based on this determine an approximation to a given input vector (signal, function).Applica",{"id":392,"funder":7,"programme":8,"title":393,"piName":10,"institution":394,"country":45,"year":13,"amount":395,"abstract":396},"cordis-marie-skłodowska-curie-actions-award-25796","Dynamics of Homeomorphisms, Noninvertible Maps and Flows with Respect to Minimality","UNIVERSITE PARIS 13","€207,786","The project is in the area of Topological Dynamics, one of the main branches of the Theory of Dynamical Systems. We study minimality in discrete-time dynamical systems given by noninvertible continuous maps or homeomorphisms, as well as in continuous-time dynamical systems given by continuous flows.Our attention will be focused on, but not reduced to, the following problems:1. Existence of minimal maps and\u002For homeomorphisms on manifolds and more general spaces;2. Classification of minimal sets o",{"id":398,"funder":7,"programme":8,"title":399,"piName":10,"institution":400,"country":45,"year":13,"amount":401,"abstract":402},"cordis-marie-skłodowska-curie-actions-award-24587","Nodulation as a model system to study the role of remorins, plant specific lipid raft proteins, potentially involved in symbiotic signalling","INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE","€158,786","50-70% of the world biological nitrogen fixation, leading to a terrestrial input of 40-50 million tons of nitrogen per year, is carried out by symbiotic nitrogen fixation (SNF), mostly between bacteria of the family Rhizobiaceae and legume plants. A specif ic molecular dialogue takes place during the early steps of the symbiosis, leading to the production of key signalling lipooligosaccharides (Nod factors) by the bacterial partner. Nod factors are essential for the production of specific organs",{"id":404,"funder":7,"programme":8,"title":405,"piName":10,"institution":406,"country":12,"year":13,"amount":407,"abstract":408},"cordis-marie-skłodowska-curie-actions-award-22790","Molecular basis for chromosome cohesion in sporulating cells of Bacillus subtilis","UNIVERSITY OF NEWCASTLE UPON TYNE","€168,233","Efficient segregation of chromosomes is crucially important in all living organisms. In eukaryotes, cohesion of the replicated chromosomes is an important step in this process, which occurs prior to attachment to the mitotic spindle apparatus. Chromosome cohesion also occurs in some prokaryotes. In sporulating cells of Bacillus subtilis the replicated sister chromosomes adopt an unusual extended conformation, known as the axial filament, which reaches from one cell pole to the other. It is well-",{"id":410,"funder":7,"programme":8,"title":411,"piName":10,"institution":412,"country":45,"year":13,"amount":413,"abstract":414},"cordis-marie-skłodowska-curie-actions-award-9951","Photosynthesis: What controls the membrane protein Ring Size?","COMMISSARIAT A L'ENERGIE ATOMIQUE","€205,474","During the last decade life sciences have witnessed a spectacular progress in structural biology with the structures of many important biomolecules coming available. However, up to now, only a few structures of membrane proteins have been determined, even although as many as 20 to 40% of the genes of all sequenced genomes code for such macromolecules.Photosynthetic membrane proteins have been at the forefront of membrane protein science, because they generally bind chlorophyll and carotenoid cof",{"id":416,"funder":7,"programme":8,"title":417,"piName":10,"institution":375,"country":12,"year":13,"amount":20,"abstract":418},"cordis-marie-skłodowska-curie-actions-award-41522","Porphyrin dimers for photodynamic therapy via two photon absorption","Conjugated porphyrin dimers are promising chromophores for photodynamic therapy (PDT) because of their strong two-photon absorption at wavelengths around 850 nm, as well as their strong one-photon absorption between 650-750 nm. PDT via two-photon absorption, using a pulsed Ti-sapphire laser, should be an effective method for treating age-related macular degeneration (AMD) which is a common cause for blindness.The advantage of two-photon excitation is that it minimises collateral damage. These ch",{"id":420,"funder":7,"programme":8,"title":421,"piName":10,"institution":375,"country":12,"year":13,"amount":407,"abstract":422},"cordis-marie-skłodowska-curie-actions-award-25413","The role of the right hemisphere in language recovery following stroke","The potential of the right hemisphere to contribute to language recovery following lesions acquired in adulthood is controversial. On the one hand, post-lesional right hemispheric activation is often seen in patients showing poor language recovery. This seems to imply that language recovery relies mainly on spared left hemispheric language areas. On the other hand, contralesional areas might be particularly critical for residual language function in patients being most severely affected.   This ",{"id":424,"funder":7,"programme":8,"title":425,"piName":10,"institution":426,"country":427,"year":13,"amount":428,"abstract":429},"cordis-marie-skłodowska-curie-actions-award-21898","Mitochondrial biogenesis: evolution of molecular machines","FACULTY OF SCIENCE, CHARLES UNIVERSITY","CZ","€205,863","The evolution of eukaryotes required creation of protein targeting pathways to ensure discrete populations of proteins could be sent into each compartment. Various compartments, such as mitochondria, plastids, the nucleus and peroxisomes are eukaryote-spec ific and building protein targeting pathways for these compartments depended on the de novo creation of specific molecular machines. The purpose of this project is to search for and characterize components of equivalent molecular machines in t",{"id":431,"funder":7,"programme":8,"title":432,"piName":10,"institution":433,"country":102,"year":13,"amount":434,"abstract":435},"cordis-marie-skłodowska-curie-actions-award-21347","Interfacial Electrochemical Bacterial Recognition","UNIVERSIDAD DE ALICANTE","€148,648","The aim of this project is to investigate fundamental aspects of the physical chemistry of bacterial cell \u002F substrate interactions. Well-defined surfaces of both single crystals and multilayered gold deposits on quartz elements will be used to resolve the interfacial electrochemistry by capacitance measurements. The use of single crystal electrodes is essential in order to avoid the uncertainties of classical electrode surfaces that have a surface rugosity of the same order of magnitude as the d",{"id":437,"funder":7,"programme":8,"title":438,"piName":10,"institution":439,"country":45,"year":13,"amount":440,"abstract":441},"cordis-marie-skłodowska-curie-actions-award-40079","Famine and death in Western Europe, 10001350: Origins and Internationalisation of the European subsistence and mortality crises","UNIVERSITE PARIS I PANTHEON-SORBONNE","€198,670","In the proposed course of postdoctoral research at the LaMOP (Universite de Paris I), the applicant, Dr. Pere Benito, aims to investigate the international scope of the alimentary crises of the High Middle Ages (1000-1350) and their relation to mortality and to great pandemics.This project is a continuation of three years of work at the University of Barcelona aimed at establishing, on a regional scale, the chronology, duration and relative gravity of the periods of dearth that Catalonia experie",{"id":443,"funder":7,"programme":8,"title":444,"piName":10,"institution":208,"country":209,"year":13,"amount":445,"abstract":446},"cordis-marie-skłodowska-curie-actions-award-25850","Phylogeny and systematics of the orb-weaver family Araneidae (Araneae, Araneoidea).","€190,110","The spider family Araneidae represents one of the largest spider families. In spite of this, relationships within the family still remain doubtful. Our study will use morphological characters to reconstruct the phylogeny of Araneidae. The number of studied genera covers 50% of the family. New characters will be derived from extensive scanning electron microscopy. This will also generate an important SEM atlas for a wide selection of Araneid taxa, as well as representatives of 10 closely related ",{"id":448,"funder":7,"programme":8,"title":449,"piName":10,"institution":450,"country":58,"year":13,"amount":451,"abstract":452},"cordis-marie-skłodowska-curie-actions-award-21854","Biomimetic surface modification of tissue engineering scaffolds with glycosaminoglycans","MARTIN-LUTHER-UNIVERSITÄT HALLE WITTENBERG","€158,198","The replacement of bone and cartilage by tissue engineering is still hampered by the lack of degradable biomaterials that stimulate the growth and differentiation of cells. The layer-by-layer (LbL) technique has been identified as a useful tool to immobili se biogenic ligands maintaining their biological activity. It is an environmental safe, simple and cost efficient method to create material surfaces that are organised at the nanometer scale. LbL technique has been applied recently to coat the",{"id":454,"funder":7,"programme":8,"title":455,"piName":10,"institution":456,"country":45,"year":13,"amount":457,"abstract":458},"cordis-marie-skłodowska-curie-actions-award-23942","Subcellular localisation of metals in the ectomycorrhizal fungus Suillus bovinus and its host plant Pinus sylvestris: a comparative study of metal tolerant and non-tolerant isolates","UNIVERSITE JOSEPH FOURIER GRENOBLE 1","€158,218","Zinc and copper are essential nutrients required for many biological processes (e.g. cofactor in many proteins). Despite their importance, excess Zn and Cu are toxic. For this reason, organisms have evolved with mechanisms of metal homeostasis that tightly control the intracellular level of metals when extra-cellular concentrations change. Genetic adaptation towards higher Zn and Cu tolerance was found in ectomycorrhizal fungi of the genus Suillus, originating from highly metal contaminated area",{"id":460,"funder":7,"programme":8,"title":461,"piName":10,"institution":462,"country":45,"year":13,"amount":463,"abstract":464},"cordis-marie-skłodowska-curie-actions-award-25678","Beam Stability in Modern Light Sources via Frequency Map Analysis","OBSERVATOIRE DE PARIS","€208,352","Advanced non-linear dynamics methods such as the frequency map analysis have proved very efficient in improving the performance of modern accelerators. In particular, the correction of the inherent high chromaticity in extremely low emittance lattices in modern light sources necessitates high sextupole fields, which significantly reduce the dynamic aperture. In these cases, classical dynamics approaches based on leading order perturbation theory are insufficient. The purpose of this research pro",{"id":466,"funder":7,"programme":8,"title":467,"piName":10,"institution":295,"country":45,"year":13,"amount":468,"abstract":469},"cordis-marie-skłodowska-curie-actions-award-39369","Lorentz violatining brane-world models and their cosmological relevance","€151,981","In recent years, observational evidence for an accelerated expansion of the Universe has triggered investigation of non-conventional cosmological models. At the same time, the precision reached in the observation of the Cosmic Microwave Background Radiation (CMBR) offers the possibility of detecting deviations from the predictions of ordinary models of the Early Universe.In particular, models in which the observed Universe is a four-dimensional surface in a higher dimensional space-time (so call",{"id":471,"funder":7,"programme":8,"title":472,"piName":10,"institution":473,"country":58,"year":13,"amount":474,"abstract":475},"cordis-marie-skłodowska-curie-actions-award-22052","Structural and functional determinants of GRK2 in cardiac development","UNIVERSITAETSKLINIKUM FUER DIE MEDIZINISCHE FAKULTAET DER ALBERT-LUDWIGS-UNIVERSITAET FREIBURG","€257,098","G protein-coupled receptor kinases (GRK) provide the rate-limiting step for terminating incoming signals at G protein-coupled receptors (GPCR) to protect the cell from over-stimulation. GRK2, the most commonly expressed GRK, has been shown to regulate hear t function in the adult and during development as GRK2 knockout (KO) mice die during embryonic development. Since the reason for the embryonic lethality has been analysed only preliminary, I want to uncover the molecular mechanism to provide a",{"id":477,"funder":7,"programme":8,"title":478,"piName":10,"institution":479,"country":58,"year":13,"amount":480,"abstract":481},"cordis-marie-skłodowska-curie-actions-award-24731","Synthesis and Assembly of Polymeric Nanotubes for Optical Biosensing","MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.","€149,722","Nanotechnology involves the creation and utilization of materials and devices on the nanometer scale. In our days, biosensors are among the most promising nanotechnological achievements. They have emerged as reliable analytical tools in biomedicine, biolog y and environmental control. Recent developments of fabrication processes in the nanometer range by template based synthesis and deposition techniques have supplied new impetus to the concept of biosensor membranes. Methods for the production ",{"id":483,"funder":7,"programme":8,"title":484,"piName":10,"institution":485,"country":45,"year":13,"amount":486,"abstract":487},"cordis-marie-skłodowska-curie-actions-award-515086","Lattice one boson exchange Models","CENTRE NATIONAL DE LA RECHERHCE SCIENTIFIQUE","€150,237","The projects aims to make for the first time a full non perturbative treatment of the effective nuclear interaction via beson exchange based on a lattice simulation like those actually made for QCD. One Boson ExchangeModels are an effective modelization of the nucleón interaction that has proved its success in a great number of tests, but that nevertheless is not able (with present calculations) to give a reasonable picture of the binding energies for nuclei with more than two particles. This is",{"id":489,"funder":7,"programme":8,"title":490,"piName":10,"institution":491,"country":10,"year":13,"amount":492,"abstract":493},"cordis-marie-skłodowska-curie-actions-award-25073","Hard probes of high-density Quantum Chromo Dynamics in high-energy hadronic collisions at CERN-LHC.","EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH - CERN","€236,946","This proposal focuses on the experimental study of the phase diagram of Quantum Chromo Dynamics (QCD), the fundamental theory of the strong interaction and one of the pillars of the Standard Model, at extreme values of energy and particle density. The goal of this research project is to quantitatively characterise the physical properties of two QCD media: the Quark-Gluon-Plasma (QGP) and the Color-Class-Condensate (CGC), via the study of the modifications suffered by hard probes (particles with ",{"id":495,"funder":7,"programme":8,"title":496,"piName":10,"institution":295,"country":45,"year":13,"amount":497,"abstract":498},"cordis-marie-skłodowska-curie-actions-award-25064","Cross-kingdom investigation of the mammalian retroviral silencing suppressor Tas to identify novel silencing factors","€149,670","RNA silencing is a fundamental process controlling gene expression in eukaryotes. Although a set of core proteins that initiate and execute RNA silencing have been identified, the complexity of the pathways involved suggests that additional components are yet to be discovered. In particular, negative regulatory pathways of RNA silencing remain poorly understood, although evidence for their existence has recently emerged. Such pathways are likely to be recruited by viral suppressors of silencing.",{"id":500,"funder":7,"programme":8,"title":501,"piName":10,"institution":502,"country":216,"year":13,"amount":503,"abstract":504},"cordis-marie-skłodowska-curie-actions-award-40496","Membrane protein structure prediction based on ROSETTA","STOCKHOLM UNIVERSITY","€264,248","Integral helical membrane proteins constitute about 20% of all proteins encoded by most genomes and they play crucial role in cell function and communication. In addition, the medical importance of membrane bound receptors, channels, and pumps as targets f or drugs are well established.However, several experimental reasons makes it difficult to obtain the structure of membrane proteins, only 0.6% (168 out of 28,000) of the solved protein structures in the Protein Data Bank (PDB) are membrane pro",{"id":506,"funder":7,"programme":8,"title":507,"piName":10,"institution":508,"country":12,"year":13,"amount":272,"abstract":509},"cordis-marie-skłodowska-curie-actions-award-24920","Advanced optical waveguide analysis of proteins and cells","CRANFIELD UNIVERSITY","A new type of optical waveguide will be developed in order to enable individual living eucaryotic cells to be monitored in situ with extremely high resolution. Their response to drugs, toxins and other xenobiotics as well as viruses can thereby be comprehensively monitored. Bacterial-eucaryote interactions can also be monitored. The novel waveguide will form the core of a new type of universal nanodevice for clinical diagnostics and toxicity testing.",{"id":511,"funder":7,"programme":8,"title":512,"piName":10,"institution":513,"country":45,"year":13,"amount":486,"abstract":514},"cordis-marie-skłodowska-curie-actions-award-23188","Molecular approach to the study of antibiotic susceptibility of Neisseria meningitidis and of its impact on pathogenesis of meningococcal infection","INSTITUT PASTEUR","Neisseria meningitidis is a leading cause of meningitis and septicemia worldwide, associated with a high mortality rate. Since the increasing number of culture negative cases has been observed, and an immediate initiation of proper antibiotic therapy is crucial for favourable outcomes, there is an urgent need to develop rapid and specific non-culture methods of predicting of meningococcal susceptibility to penicillin. Although penicillin remains the drug of choice in the treatment of invasive me",{"id":516,"funder":7,"programme":8,"title":517,"piName":10,"institution":518,"country":216,"year":13,"amount":519,"abstract":520},"cordis-marie-skłodowska-curie-actions-award-39299","Mapping the strong potential","LUNDS UNIVERSITET","€109,626","I will extract information on the form of the strong nuclear potential through a procedure I will develop for analysing data from the ATLAS Experiment at the Large Hadron Collider at the European Laboratory for Particle Physics (CERN). I will carry out this work at Lund University in collaboration with Professor Paula Eerola, an internationally recognized authority on the subject. The nature of the strong force, including the form of the strong potential, determines to a large extent what bound ",{"id":522,"funder":7,"programme":8,"title":523,"piName":10,"institution":524,"country":216,"year":13,"amount":525,"abstract":526},"cordis-marie-skłodowska-curie-actions-award-42218","Characterization of the role of the FLOWERING LOCUS T mRNA transport in the regulation of flowering time","SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES","€158,016","The regulation of plant flowering time is a highly adaptive trait. Plants must integrate a multitude of environmental and internal signals in order to flower at the right time of the year. One of the most important factors regulating flowering time is the length of the day, where some plants, like Arabidopsis, respond to a lengthening of the day in order to flower in the spring. Since the 1930s it has been clear that the day-length regulation of flowering time is controlled by a substance moving",{"id":528,"funder":7,"programme":8,"title":529,"piName":10,"institution":166,"country":12,"year":13,"amount":530,"abstract":531},"cordis-marie-skłodowska-curie-actions-award-21353","The evolution of parasite virulence","€262,610","Understanding parasite virulence is a challenge for evolutionary biology. Intuitively, parasites that rely on their hosts for their fitness should be benign, yet many parasites cause harm (virulence). Two main theories exist to explain parasite virulence. First, it is believed that virulence is an unavoidable consequence of a parasite maximising its fitness: in order to obtain transmission to the next host, it needs to exploit its current host, at the same time causing damage. Second, within-hos",{"id":533,"funder":7,"programme":8,"title":534,"piName":10,"institution":535,"country":32,"year":13,"amount":536,"abstract":537},"cordis-marie-skłodowska-curie-actions-award-25098","Identification and characterization of target genes regulated by KNOX transcription factors in different plant species","CONSIGLIO NAZIONALE DELLE RICERCHE","€147,716","Animals develop all their organs entirely during embryogenesis. On the contrary, only few organs are established during plant embryogenesis. The development of all the plant organs depends on post-embryonic activity of the shoot apical meristem (SAM) and t he root meristem, which are established during embryogenesis.Plant development and growth depends on the ability of the SAM to renew itself and at the same time differentiate into various organs. These processes are strictly regulated and coor",{"id":539,"funder":7,"programme":8,"title":540,"piName":10,"institution":19,"country":12,"year":13,"amount":407,"abstract":541},"cordis-marie-skłodowska-curie-actions-award-22946","Visualisation and analysis of exo- and endocytosis events at neuronal synapses of the zebrafish","The basic aim of this proposal is to investigate the molecular mechanisms of fast and slow endocytosis at the synapse. We will generate stable lines of zebrafish expressing fluorescent proteins thought to be involved in endocytosis under control of neuron al promoters; then use TIRFM to monitor recruitment of these proteins to the presynaptic membrane in the giant synaptic terminal of retinal bipolar cells. In particular, we will produce zebrafish lines expressing the fluorescent fusion proteins",{"id":543,"funder":7,"programme":8,"title":544,"piName":10,"institution":545,"country":216,"year":13,"amount":546,"abstract":547},"cordis-marie-skłodowska-curie-actions-award-41694","Atomic structure, selectivity and nanostructuring of biomolecules on silicon carbide surfaces","LINKÖPINGS UNIVERSITET","€157,449","Major objective of this proposal is a detailed structural characterization of biomolecular adsorbates on silicon carbide surfaces. By combining scanning tunnelling microscopy, low energy electron diffraction, high-resolution photoelectron spectroscopy and infrared spectroscopy, an atomic level understanding of the role of nanochemistry and nanostructure are possible to achieve.This will allow detailed electronic and chemical characterizations of the surface\u002Finterface properties of selected biomo",{"id":549,"funder":7,"programme":8,"title":550,"piName":10,"institution":551,"country":209,"year":13,"amount":552,"abstract":553},"cordis-marie-skłodowska-curie-actions-award-21629","Deprogramming of the mammalian genome for stem cell production","THE UNIVERSITY OF COPENHAGEN","€258,351","Cell based therapies potentially allow for alternative treatment of several human diseases. The search for an autologous cell source merits the investigation of novel means to de-program patient derived differentiated cells into pluripotent embryonic stem (ES) cells (or ES-like cells) with therapeutic potentials. The technique of cloning by somatic cell nuclear transfer (SCNT), where a differentiated somatic cell is transferred into an enucleated oocyte has now in several mammalian species prove",{"id":555,"funder":7,"programme":8,"title":556,"piName":10,"institution":557,"country":58,"year":13,"amount":558,"abstract":559},"cordis-marie-skłodowska-curie-actions-award-22123","Genomics and genetics of spider mite Tetranychus urticae: development of novel model organism important for agriculture","MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V.","€205,046","In this application I propose to use a combination of genomic and genetic studies to develop tools for the development of a novel model chelicerate, the two spotted spider mite Tetranychus urticae. This proposal merges the previous genomic work of my lab with training in forward and reverse genetics at the Max Planck Institute in Tübingen to advance the first model organism in the Chelicerata, the second largest group of animals. This is the first model organism that is going to combine importan",{"id":561,"funder":7,"programme":8,"title":562,"piName":10,"institution":563,"country":65,"year":13,"amount":564,"abstract":565},"cordis-marie-skłodowska-curie-actions-award-40133","Experimental and theoretical investigations on the microtubule-mediated formation of intracellular protein patterns","STICHTING VOOR FUNDAMENTEEL ONDERZOEK DER MATERIE","€148,708","A key question in modern cell biology is how intracellular spatial order is established and maintained. Here, we propose to investigate the physical principles of the formation of intracellular protein patterns, using a multidisciplinary approach that combines quantitative live-cell imaging with computational modeling.As an in vivo model system we will use fission yeast, which is distinguished by its extraordinarily well-defined shape and intracellular order. In fission yeast, a dynamic microtub",{"id":567,"funder":7,"programme":8,"title":568,"piName":10,"institution":569,"country":65,"year":13,"amount":570,"abstract":571},"cordis-marie-skłodowska-curie-actions-award-41546","Role of Ldb1 binding partners Eto2 and cdk9 during stem cells development and erythroid differentiation","ERASMUS MC","€156,624","Ldb1, a ubiquitously expressed LIM domain binding protein, is essential in a number of tissues during development. It interacts with Gata1, Tal1, E2A and Lmo2 to form a transcription factor complex regulating late erythroid genes.It has been identified by the host laboratory a number of novel Ldb1 interacting proteins in erythroleukemic cells, in particular the repressor protein Eto2 (and its family member Mtgr1) and the cyclin dependent kinase Cdk9. Morpholino mediated knockdowns in zebrafish s",{"id":573,"funder":7,"programme":8,"title":574,"piName":10,"institution":575,"country":12,"year":13,"amount":144,"abstract":576},"cordis-marie-skłodowska-curie-actions-award-24441","Gene silencing-based functional screening for genes regulating invasion in human cancer cells","KING'S COLLEGE LONDON BUSINESS LTD","The proposed project uses a RNA interference-based loss-of-function genetic screen in cancer cells to identify and study proteins with a role in tumor cell invasion. A retroviral vector-based human RNAi library and a set of syntethics iRNAs will be used to suppress the expression of specific genes in cancer cells. The library targets around 8000 human genes selected for their association with cancer and other human diseases and include entire gene families suitable for being therapeutical target",{"id":578,"funder":7,"programme":8,"title":579,"piName":10,"institution":580,"country":364,"year":13,"amount":581,"abstract":582},"cordis-marie-skłodowska-curie-actions-award-21717","Function and evolution of uncoupling proteins in Drosophila melanogaster","UNIVERSITY OF LAUSANNE","€269,720","At the beginning of 1997, it seemed that the research on the mitochondrial uncoupling protein (UCP) could not lead to any new surprises. One member of this proton carrier family was known at that time. This UCP is present in mammalian mitochondria and is a key component of non-shivering thermogenesis.However, during the seven last years, genome-sequencing programs have identified novel UCPs in mammals but also in many other eukaryotes including unicellular organisms, fungi, and plants. New funct",{"id":584,"funder":7,"programme":8,"title":585,"piName":10,"institution":586,"country":45,"year":13,"amount":587,"abstract":588},"cordis-marie-skłodowska-curie-actions-award-25683","Characterization of novel proteins interacting with cubilin and their role in proximal tubular endocytosis","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","€214,590","Megalin and cubilin mediated endocytosis at the apical pole of proximal tubule epithelial cells constitute a major route for renal retrieval of several essential glomerular filtrate solutes such as proteins vitamins and calcium. Pathophysiological signific ance of these receptors is supported by the finding of low-molecular weight proteinuria in megalin knockout mice and in dogs that bear inherited disorder of cubilin intracellular trafficking although the structure of cubilin is normal. Recentl",{"id":590,"funder":7,"programme":8,"title":591,"piName":10,"institution":592,"country":216,"year":13,"amount":593,"abstract":594},"cordis-marie-skłodowska-curie-actions-award-39254","Is heat shock protein mediated protection against ageing and protein oxidation tissue specific?","GÖTEBORGS UNIVERSITET","€195,730","Aging is a biological process that is not yet understood. The free radical hypothesis of aging states that is a causal relationship between the oxidation status and lifespan such that the progressive deterioration of aging organisms is a consequence of cumulative oxidation damage. In line with this, intracellular accumulation of misfolded and oxidatively damaged proteins, e.g. carbonylated proteins, has repeatedly been associated with aging and the diseases of aging. Such accumulation can be cou",{"id":596,"funder":7,"programme":8,"title":597,"piName":10,"institution":295,"country":45,"year":13,"amount":598,"abstract":599},"cordis-marie-skłodowska-curie-actions-award-24683","VALIDATION OF GENES POTENTIALLY RESPONSIBLE FOR THE TOLERANCE AND HEAVY METAL HYPERACCUMULATION ABILITY IN HIGHER PLANTS USING QTL MAPPING AND THE TOOLS OF MOLECULAR EVOLUTION","€204,910","A rare class of plants named hyperaccumulators can tolerate heavy metals and also accumulate such metals to extremely high concentrations in their shoots. Classical techniques of screening have given clues to isolated genes involved in metal tolerance and homeostasis. However, their direct relationship with metal adaptation has not yet been established and the major genes of tolerance remain to be identified. Within the Arabidopsis genus, A. halleri has been shown to tolerate and hyperaccumulate",{"id":601,"funder":7,"programme":8,"title":602,"piName":10,"institution":603,"country":388,"year":13,"amount":604,"abstract":605},"cordis-marie-skłodowska-curie-actions-award-40833","Function-based expression screen for genes involved in gastrulation of the basal metazoan Nematostella vectensis","UNIVERSITäT WIEN","€173,408","The questions of how genetic programs regulate the formation of a complex multi-cellular body and how these genetic programs evolved are key topics of the modern developmental biology. Cnidarians are of especial interest for the Evolution and Development field, as they occupy a unique evolutionary position of a sister group to all bilaterian Eumetazoa. There are two main features, which make Cnidaria distinct from all the other multi-cellular animals: the lack of typical bilateral symmetry and t",{"id":607,"funder":7,"programme":8,"title":608,"piName":10,"institution":609,"country":216,"year":13,"amount":610,"abstract":611},"cordis-marie-skłodowska-curie-actions-award-23645","Genetic compatibility and the evolution of mate choice","UPPSALA UNIVERSITET","€165,921","Recent empirical evidence suggests that individuals use genetic compatibility (or genetic dissimilarity) as a criterion when choosing mates. Heterozygote offspring should have a fitness advantage compared with homozygotes and therefore females choose the m ales that share the fewest alleles across loci with the female - the genetically compatible males. We propose to study the effect of genetic incompatibility on fitness and female choice for genetic compatible males in selection experiments usi",{"id":613,"funder":7,"programme":8,"title":614,"piName":10,"institution":615,"country":58,"year":13,"amount":616,"abstract":617},"cordis-marie-skłodowska-curie-actions-award-21797","Simulating Chiral Gauge theory with Matrix Models : Non-commutative Geometry and Fuzzy Approximations","HUMBOLDT-UNIVERSITÄT ZU BERLIN","€148,558","Non-commutative geometry was proposed earlier than renormalization as a possible way to eliminate ultraviolet divergences in quantum field theories. On the other hand quantum field theories on non-commutative spaces are generally unknown beyond the one-lo op approximation. A gauge-covariant, chiral-invariant regularization of gauge theories can be achieved by quantizing the underlying space-time manifold thereby replacing it by a non-commutative matrix model or a fuzzy manifold''. Indeed if the ",{"id":619,"funder":7,"programme":8,"title":620,"piName":10,"institution":621,"country":216,"year":13,"amount":622,"abstract":623},"cordis-marie-skłodowska-curie-actions-award-22215","Characterization of a planar polarity-signalling cascade in the Arabidopsis root epidermis","SVERIGES LANTBRUKSUNIVERSITET","€167,055","Planar polarity, the polar orientation of cells within the plane of a tissue layer, is intensively studied in animals, but little is known about planar epidermal polarity in plants. We study polar root hair positioning close to distal ends of hair-forming cells (trichoblasts) in the Arabidopsis root epidermis. We have isolated the recessive beatnik (btk) mutant that displays root-specific phenotypes such as long hairs and hyperpolarized hair initiation at distal-most ends of trichoblasts. Map-ba",{"id":625,"funder":7,"programme":8,"title":626,"piName":10,"institution":627,"country":32,"year":13,"amount":628,"abstract":629},"cordis-marie-skłodowska-curie-actions-award-40156","Early discoveries at the LHC with the CMS silicon strip tracker","ISTITUTO NAZIONALE DI FISICA NUCLEARE","€93,655","The Compact Muon Solenoid (CMS) experiment is one of four high-energy physics experiments presently in the final stages of construction to operate at the Large Hadron Collider (LHC) facility at CERN, Geneva.In 2007 the LHC will produce head on collisions between 7 TeV protons, making it the most powerful accelerator ever built. One of the main motivations to built the LHC is its potential to discover new physics at the TeV scale that is strongly expected given the current experimental and theore",{"id":631,"funder":7,"programme":8,"title":632,"piName":10,"institution":633,"country":364,"year":13,"amount":634,"abstract":635},"cordis-marie-skłodowska-curie-actions-award-24178","Precision study of heavy quark production at high energy colliders","UNIVERSITAET ZUERICH","€180,620","Heavy quark production is intensively studied at present and future elementary particle physics experiment, providing not only a test for perturbative QCD, but also a background to monitor for discovering new-physics processes. Several dedicated experiments were recently commissioned to study bottom-quark production, and the measurement of top-quark production is one of the main objectives of the high energy collision physics program at the Fermilab Tevatron and CERN LHC. At present, the theoret",{"id":637,"funder":7,"programme":8,"title":638,"piName":10,"institution":639,"country":32,"year":13,"amount":640,"abstract":641},"cordis-marie-skłodowska-curie-actions-award-24624","Development of theoretical tools for the future LHC heavy-ion program at CERN: high-pt particles and parton distributions","UNIVERSITA DI ROMA LA SAPIENZA","€197,408","The study of high density nuclear matter,where new states are predicted by QCD, is the new frontier on the physics of the strong interaction. The experimental program of ultrarelativistic heavy-ion collisions aims to form and study these new phases. One of the main tools to characterize the created medium is the detection of particles produced with high transverse momentum: these particles are usually produced in form of 'jets', and the medium-modification of these jets carries essential informa",{"id":643,"funder":7,"programme":8,"title":644,"piName":10,"institution":38,"country":12,"year":13,"amount":645,"abstract":646},"cordis-marie-skłodowska-curie-actions-award-25781","Bioactive Nickel Titanium Shape Memory Alloys for Enhanced Osseo-integration","€127,592","The near equiatomic intermetallic nickel titanium (NiTi) has remarkable properties. It is a shape memory alloy that exhibits considerable super-elasticity. Super-elastic NiTi is of special interest as it has elastic properties which are far closer to bone than conventional metallic materials. Although concerns have been expressed regarding the high quantity of potentially toxic nickel in the metal; a wide range of studies have shown that nickel release from these alloys is low and poses little r",{"id":648,"funder":7,"programme":8,"title":649,"piName":10,"institution":650,"country":12,"year":13,"amount":651,"abstract":652},"cordis-marie-skłodowska-curie-actions-award-23691","South American Permo-Triassic Fish Fauna Turnover and its Bearing on the Mass Extinction Scenario","THE NATURAL HISTORY MUSEUM","€171,634","Global extinctions, their causes, duration and recovery phases are still disputed on the basis of localized palaeontological and geochemical evidence. The greatest mass extinction allegedly affected 70-90 per cent of animal and plant species worldwide at t he P-T boundary (PTB), approximately 250 million years before present, but has been poorly studied in South America.This multidisciplinary project seeks to investigate key strata from that continent in order to gather palaeontological and geoc",{"id":654,"funder":7,"programme":8,"title":655,"piName":10,"institution":656,"country":32,"year":13,"amount":657,"abstract":658},"cordis-marie-skłodowska-curie-actions-award-24995","Advanced Electron Microscopy Study of Magnetic Nanocomposites","UNIVERSITA DEGLI STUDI DI CAGLIARI","€96,068","This proposal aims to apply advanced electron microscopy techniques to the study of magnetic nanocomposite materials, in particular sol-gel prepared FeCo oxide and alloy nanoparticles in silica and alumina matrices, which are promising for magnetic applica tions. These materials have previously been studied using detailed X-ray absorption spectroscopy measurements (in which the researcher was involved). However, there remain questions about variations in homogeneity of the nanoparticles, and the",{"id":660,"funder":7,"programme":8,"title":661,"piName":10,"institution":662,"country":12,"year":13,"amount":20,"abstract":663},"cordis-marie-skłodowska-curie-actions-award-38106","Early stages of amyloid fibrils formation elucidated by single-molecule fluorescence two-colour coincidence detection","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","The amyloid diseases, including for instance Alzheimer and Parkinson's diseases, are being actively investigated in recent years by biophysicists, biochemists, or neuroscientists. Despite of this, the fibrillogenesis mechanisms and the early events of fibril formation are still not well understood. Nonetheless, they are crucial for a better understanding and future improvements in healthcare particularly since there is growing evidence that it is the small oligomers that cause cell death. Theref",{"id":665,"funder":7,"programme":8,"title":666,"piName":10,"institution":667,"country":32,"year":13,"amount":668,"abstract":669},"cordis-marie-skłodowska-curie-actions-award-24785","Mechanisms promoting the formation and migration of cruciform sister chromatid junctions during chromosome replication","IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE","€143,746","Eukaryotic cells replicate their genome by firing multiple replicons throughout the S phase of the cell cycle. Origin firing is a highly controlled process and is coupled with the formation of specialized cruciform junctions. These structures have been con served throughout evolution and likely contribute to the establishment of sister chromatid cohesion during S phase and to assist sister chromatid-mediated replication and recombination processes. Under pathological situations these sister chro",{"id":671,"funder":7,"programme":8,"title":672,"piName":10,"institution":513,"country":45,"year":13,"amount":673,"abstract":674},"cordis-marie-skłodowska-curie-actions-award-25456","Comparative structure-function analysis of the dengue virus envelope protein in complex with relevant ligands from the host","€149,104","We propose to solve the crystal structures of the dengue virus (DV) envelope (E) protein from different serotypes in complex with immunologically relevant ligands from the human host.These will be:- Dendritic cell-specific ICAM-3 grabbing non-integrin (DC -SIGN). This molecule has been shown to be essential for entry of mosquito-grown virus into human dendritic cells.- Fab fragments from antibodies capable of neutralising one or more DV serotypes.In both cases we will be especially interested in",{"id":676,"funder":7,"programme":8,"title":677,"piName":10,"institution":678,"country":65,"year":13,"amount":679,"abstract":680},"cordis-marie-skłodowska-curie-actions-award-39147","Fate of land-derived organic compounds in the coastal ocean","STICHTING KONINKLIJK NEDERLANDS INSTITUUT VOOR ONDERZOEK DER ZEE","€157,759","The main goal of this project is to characterize the sources of organic matter (terrestrial vs. marine) in the coastal zone. We will apply lipid biomarkers in combination with more conventional organic tracers. The innovative aspect of this project rests o n the application of a newly developed proxy for terrestrial organic matter characterization to a modern marine environment. For this purpose, the BIT (Branched and Isoprenoid Tetraether) index based on specific organic compounds will be appli",{"id":682,"funder":7,"programme":8,"title":683,"piName":10,"institution":684,"country":12,"year":13,"amount":20,"abstract":685},"cordis-marie-skłodowska-curie-actions-award-40042","Novel strategies for the total synthesis of bioactive macrocyclic natural products","IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE","The synthesis of natural compounds with biological activity is one of the most important areas in organic chemistry, and also for the agrochemical and pharmaceutical industry.Polyketides are the most abundant medicinal agents among natural products. Structural diversity and wide scope of bioactivities are typical of the group. This proposal is focused upon the synthesis of resorcylate bio-active natural products and the underlying synthetic methodology.The objective of this research project is t",{"id":687,"funder":7,"programme":8,"title":688,"piName":10,"institution":689,"country":58,"year":13,"amount":690,"abstract":691},"cordis-marie-skłodowska-curie-actions-award-21604","The role of water column methane oxidation in the global carbon budget","MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V","€260,570","The release of large amounts of the greenhouse gas methane from shallow marine gas reservoirs and dissociating gas hydrates at continental margins is discussed to have advanced warming episodes in Earth's history. However, methane emitted at the seafloor is consumed partly in the ocean by microbial oxidation reducing the portion reaching the atmosphere. It is the main purpose of this project to quantify the fraction of CH4 oxidised in the water column in relation to the amount discharging, dispe",{"id":693,"funder":7,"programme":8,"title":694,"piName":10,"institution":695,"country":58,"year":13,"amount":161,"abstract":696},"cordis-marie-skłodowska-curie-actions-award-39194","Mechanisms and consequences of iNKT cell stimulation by glycolipid antigens from Sphingomonas bacteria","UNIVERSIT??TSKLINIKUM BONN F??R DEN FACHBEREICH MEDIZIN DER UNIVERSIT??T BONN","Invariant natural killer T (iNKT) cells have been implicated in diverse immune reactions, especially in the early phases, due to their rapid acquisition of effector functions. In contrast to conventional T cells, which recognise protein particles, iNKT cells recognise synthetic glycolipids, i.e. sugars linked to fatty acids.However, only very recently have natural antigens for iNKT cells been identified in Sphingomonas bacteria and iNKT cell deficient mice have a greatly delayed bacteria clearan",{"id":698,"funder":7,"programme":8,"title":699,"piName":10,"institution":700,"country":65,"year":13,"amount":701,"abstract":702},"cordis-marie-skłodowska-curie-actions-award-21922","Redox cycling of iron and manganese - the role of biosorption","UNIVERSITEIT UTRECHT","€211,435","Bacteria have a high capacity to bind metal ions at their cell surface. Sorption of metal ions onto bacterial cell walls forms the basis of several microbially based purification techniques. Sorption onto bacterial surfaces is also relevant for the mobility of nutrients and metals in subsurface environments. The proposed project is dedicated to the sorption of Fe(II) and Mn(II) onto the cell wall of two Gram-negative bacteria with metal reducing capability, Shewanella putrefaciens and Geobacter ",{"id":704,"funder":7,"programme":8,"title":705,"piName":10,"institution":609,"country":216,"year":13,"amount":706,"abstract":707},"cordis-marie-skłodowska-curie-actions-award-41813","RNA-mediated regulation in bacteria: non-coding RNAs and the role of the ubiquitous Sm-like Hfq protein","€166,488","All organisms, from bacteria to mammals, contain small RNAs (sRNAs) that participate in diverse cellular activities including RNA processing, mRNA stability, translation, etc. In the past few years, sRNAs have become one of the hottest topics with the discovery of novel classes of sRNAs and their involvement in regulatory processes (miRNAs\u002Fdevelopment, sRNA\u002Fbacterial stress responses, virulence, etc). In the enterobacterium E. coli, 50-250 sRNAs have been identified and\u002For predicted.Of the few c",{"id":709,"funder":7,"programme":8,"title":710,"piName":10,"institution":711,"country":712,"year":13,"amount":713,"abstract":714},"cordis-marie-skłodowska-curie-actions-award-42683","Energetic ultra-fast laser-driven radiation sources: Applications in Biology, Chemistry and Physics","FOUNDATION FOR RESEARCH AND TECHNOLOGY - HELLAS","EL","€1,913,751","In this project we propose the development of energetic ultra fast laser-driven radiation sources. A powerful, high repetition rate, infrared (IR) femtosecond (fs) laser will be used to produce secondary sources of radiation that will cover other parts of t he spectrum, from x-rays, UV and visible to the far-infrared, THz and micro-waves. A major advantage of these secondary sources is their ultra-short nature as they result from highly non-linear processes during the femtosecond laser pulse int",{"id":716,"funder":7,"programme":8,"title":717,"piName":10,"institution":718,"country":58,"year":13,"amount":480,"abstract":719},"cordis-marie-skłodowska-curie-actions-award-39310","Mitochondrial membrane reorganisation induced by tBid during apoptosis: cardiolipin and cytochrome c redistribution analysed by single molecule spectroscopy and microscopy","TECHNISCHE UNIVERSITAET DRESDEN","One of the main control points of programmed cell death affects the release of cytochrome c and other proapoptotic factors from the mitochondria. The detailed mechanism by which cytochrome c is completely and rapidly liberated to the cytosol is not yet well understood, but it appears to involve two steps: i) redistribution of the cytochrome c stored in the mitochondrial cristae and ii) selective permeabilization of the outer mitochondrial membrane. tBid, a proapoptotic protein of the Bcl-2 famil",{"id":721,"funder":7,"programme":8,"title":722,"piName":10,"institution":723,"country":45,"year":13,"amount":724,"abstract":725},"cordis-marie-skłodowska-curie-actions-award-22096","Relationship between living and growing corals and microbial endoliths: parasitism or mutualism","INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT","€238,315","Healthy coral reefs are maintained by a balance between constructive (corals growth) and destructive forces (bioerosion). More and more this balance is threatened by human activities. Thus, coastal and insular human populations, physically protected by c ral reefs and dependent on them for food and livelihood, are increasingly in jeopardy. To protect and to manage coral reefs, their functioning and their capacities of adaptation to anthropogenic perturbations have to be understood. Most of studi",{"id":727,"funder":7,"programme":8,"title":728,"piName":10,"institution":729,"country":364,"year":13,"amount":365,"abstract":730},"cordis-marie-skłodowska-curie-actions-award-38772","Glassy Materials: Temporal and spatial heterogeneities close to dynamical arrest","UNIVERSITY OF FRIBOURG","Our proposal aims to contribute to one of the most important open question in condensed matter physics: What is the nature of the glassy state?. It still is a great mystery why upon minor changes in composition, and in the absence of a structural transition, a solid glass is formed from a liquid. Most recent progress in the field has been made using micron sized colloidal particles as model systems for glass formers. The unifying feature of many complex materials is the unusual viscoelastic beha",{"id":732,"funder":7,"programme":8,"title":733,"piName":10,"institution":734,"country":58,"year":13,"amount":161,"abstract":735},"cordis-marie-skłodowska-curie-actions-award-21587","Exploring the dark matter of the human genome: systematic discovery of microRNA genes using high-density oligonucleotide tiling arrays and comparative genome analysis","EUROPEAN MOLECULAR BIOLOGY LABORATOY (EMBL) HEIDELBERG","Protein-coding sequences represent only a tiny fraction of the human genome. Since biologists have started to explore the puzzling remainder, the 'dark matter' of the genome, the number of known non-protein-coding genes has been growing rapidly. In particular hundreds of genes encoding microRNAs (miRNAs), regulators of key molecular processes in animals and plants, have been identified over the last five years and recent studies indicate considerably higher gene numbers. As non-coding RNA genes ",{"id":737,"funder":7,"programme":8,"title":738,"piName":10,"institution":295,"country":45,"year":13,"amount":497,"abstract":739},"cordis-marie-skłodowska-curie-actions-award-24761","HIGH-THROUGHPUT STRUCTURAL STUDIES OF PROKARYOTIC ACTIVE SECONDARY TRANSPORTERS","The proposed project is aiming at solving the crystallographic structure of some of the prokaryotic membrane proteins belonging to the family of Active Secondary Transporters, an important and heterogeneous class of symport\u002Fantiport systems involved in cel l homeostasis and conserved across all reigns of living organisms. Given the difficulty encountered in membrane protein production and crystallization, a High-Throughput approach will be used, in order to screen the highest possible number of ",{"id":741,"funder":7,"programme":8,"title":742,"piName":10,"institution":743,"country":12,"year":13,"amount":20,"abstract":744},"cordis-marie-skłodowska-curie-actions-award-515294","TGF-beta signal transduction:mechanisms of Smad2\u002F3 nucleocytoplasmic transport","CANCER RESEARCH UK - LONDON RESEARCH INSTITUTE","TGF-ß related growth factors signal through Smad proteins that transfer the signal from the receptor directly into the nucleus. The receptor-regulated Smads (R-Smads) Smad2 and SmadS arephosphorylated by the receptor kinase and form complexes with Smad4 that accumulate in the nucleus, where they participate in the regulation of gene transcription. Like Smad4, Smad2 and SmadS exhibit nucleocytoplasmic shuttling irrespective of the presence or absence of a signal.This project aims at answering two",{"id":746,"funder":7,"programme":8,"title":747,"piName":10,"institution":271,"country":12,"year":13,"amount":748,"abstract":749},"cordis-marie-skłodowska-curie-actions-award-24197","Identification of hox-regulated targets at different time points of a developmental process","€169,366","Hox genes are present in all animals with bilateral symmetry, providing a conserved mechanism to control regional differences along the body axis. However, little is known about the sets of genes that are modulated by the Hox proteins to mould morphologically distinct structures. The aim of this proposal is to analyse how the Hox proteins impinge on regulatory networks executing cell differentiation programmes. To study such a complex biological process, I will use as an experimental system the ",{"id":751,"funder":7,"programme":8,"title":752,"piName":10,"institution":166,"country":12,"year":13,"amount":753,"abstract":754},"cordis-marie-skłodowska-curie-actions-award-022161","The role of DEFECTIVE KERNEL, ADEK1, in specification of epidermal identity in Arabidopsis","€161,314","The specification of the epidermis, or outer cell-layer of the plant occurs very early in embryogenesis. ADEK1 encodes a function absolutely required for early embryogenesis, and this function is likely to be a key component of the outer cell-layer speci fication pathway. Preliminary analysis of adek1 null alleles showed that they cause early embryo lethality involving serious cellular disorganisation and loss of epidermal marker expression in Arabidopsis. In addition, RNAi knock-downs of ADEK1 ",{"id":756,"funder":7,"programme":8,"title":757,"piName":10,"institution":38,"country":12,"year":13,"amount":758,"abstract":759},"cordis-marie-skłodowska-curie-actions-award-42316","Marie-Curie grant on primary Immuno-deficiencies and Auto-Immune diseases","€1,636,377","Primary immunodeficiency diseases are rare congenital conditions. They represent an experiment of nature, demonstrating the importance of specific genes and proteins in the host defence against pathogens. In primary immuno deficiencies the susceptibility to infections often goes along with the development of autoimmune conditions. In the most prevalent human primary immunodeficiency requiring medical attention, termed Common Variable ImmunoDeficiency (CVID), the prevalence of autoimmunity is app",{"id":761,"funder":7,"programme":8,"title":762,"piName":10,"institution":763,"country":209,"year":13,"amount":764,"abstract":765},"cordis-marie-skłodowska-curie-actions-award-40785","Nano-particle characterization and toxicity","NATIONAL INSTITUTE OF OCCUPATIONAL HEALTH, DENMARK","€180,134","Given the current manufacture growth, presence of nano-particles (NP) in the environment and the future use of NP, human exposure is inevitable. Yet, the potential adverse effects on human health from exposure to NP are still largely unknown.This propos al outlines a strategy for determining how the physicochemical properties of NP influence there potential for toxicity at the National Institute of Occupational Health, Denmark and University of Copenhagen. Specifically, a wide range of NP will b",{"id":767,"funder":7,"programme":8,"title":768,"piName":10,"institution":185,"country":12,"year":13,"amount":20,"abstract":769},"cordis-marie-skłodowska-curie-actions-award-41812","Natural variation of growth control in Arabidopsis thaliana","Standard genetic analysis in model organisms focuses on laboratory-induced mutations in single genes with large phenotypic effects. However, most of the variation that we see in natural populations is due to the sum of small effects, caused by naturally occurring alleles. Each allele (or variant gene) contributes to a particular trait and are known as quantitative trait loci (QTLs). Recent advances in genomic science has made these loci accessible for the first time in several model species, suc",{"id":771,"funder":7,"programme":8,"title":772,"piName":10,"institution":773,"country":45,"year":13,"amount":774,"abstract":775},"cordis-marie-skłodowska-curie-actions-award-11475","Quillen equivalences for the cross-fertilization of higher categories","UNIVERSITE DE NICE SOPHIA-ANTIPOLIS","€143,433","Higher-dimensional categories have developed rapidly in the last few years but the theory is still rather disjointed. To date, little work has been completed to compare and link up the different parts of the theory. The applicant's PhD thesis contains the first full comparison theorems in the subject. Such a higher-dimensional language and a body of relevant results is already found in a rudimentary way throughout algebraic topology, and a need for such has arisen, almost simultaneously, in area",{"id":777,"funder":7,"programme":8,"title":778,"piName":10,"institution":31,"country":32,"year":13,"amount":779,"abstract":780},"cordis-marie-skłodowska-curie-actions-award-21861","Law and cultural heritage in Europe","€138,643","The project maps and critically examines the development of the definition and protection of 'European' cultural heritage in European and international law. It considers whether current legal regimes facilitate the European Union's objective of promoting cultural diversity.It focuses on European legal frameworks established in three principal areas:- within Europe, created at the supranational level by the EU and the Council of Europe and the national level by Member States;- inside and outside ",{"id":782,"funder":7,"programme":8,"title":783,"piName":10,"institution":784,"country":45,"year":13,"amount":785,"abstract":786},"cordis-marie-skłodowska-curie-actions-award-25771","Mechano-sensitive gene expression in embryogenesis and tumourigenesis","INSTITUT CURIE","€159,353","The coordinated regulation of developmental gene expression and morphogenetic movements during embryogenesis relies on feedback between these two systems. Activation and maintenance of the expression of genes critical for embryogenesis can be dependent on mechanical induction triggered by morphogenetic movements within the embryo. This has been demonstrated by the host laboratory for the twist-dependent invagination of the anterior foregut in Drosophila, in response to compression caused by germ",{"id":788,"funder":7,"programme":8,"title":789,"piName":10,"institution":790,"country":45,"year":13,"amount":401,"abstract":791},"cordis-marie-skłodowska-curie-actions-award-23627","Self-Assembly of Bio-Nanochips","UNIVERSITE LOUIS PASTEUR","The current proposal is devoted to the design, synthesis and investigation of chemical and physical properties of 2 2 grid-type complexes bearing biological residues, such as amino-acids, oligopeptides, nucleosides, oligonucleosides, carbohydrates or long aliphatic chains.The project involves the following specific objectives:- Design and synthesis of functionalized hydrazone-based ligands with side-chains bearing biological residues: amino-acids, oligopeptides, nucleosides, oligonucleosides, ca",{"id":793,"funder":7,"programme":8,"title":794,"piName":10,"institution":185,"country":12,"year":13,"amount":795,"abstract":796},"cordis-marie-skłodowska-curie-actions-award-022275","Root hair tip growth regulation by Arabidopsis RHD2 and ROP-GTPase genes","€160,180","Plant cells have two kinds of cell elongation systems; diffuse growth and tip growth. Tip growth is highly polarized and the growth only occurs at the tip of the cell. Root hairs are tip growing projections that arise from specialised root epidermal cells. The localization of growth to the hair tip is controlled by the local production of reactive oxygen species (ROS) produced by the RHD2 NADPH oxidase. Therefore identifying and characterising proteins that spatially regulate RHD2 activity is ce",{"id":798,"funder":7,"programme":8,"title":799,"piName":10,"institution":462,"country":45,"year":13,"amount":800,"abstract":801},"cordis-marie-skłodowska-curie-actions-award-8045","At which rate do galaxies merge in the universe? Unveiling galaxy evolution through two-dimensional kinematic studies","€144,000","Mergers of galaxies play an important role in the evolution of galaxies. If merging is at work during the lifetime of galaxies, then the space density, mass, luminosity and morphology of galaxies must change with epoch making the evolution of the merger ra te with redshift a key observable that can be used to test galaxy formation models. Time-scales associated with merging are not straightforward to constraint since there is a considerable uncertainty in any transformation from an instantaneous",{"id":803,"funder":7,"programme":8,"title":804,"piName":10,"institution":805,"country":388,"year":13,"amount":806,"abstract":807},"cordis-marie-skłodowska-curie-actions-award-40190","Development of a microscopically realistic 3D Computer model of a Ventricular Wall to study microstructure-related mechanisms underlying the formation of post-shock Isoelectric Windows","MEDIZINISCHE UNIVERSITAET GRAZ (MEDICAL UNIVERSITY OF GRAZ)","€196,642","Several multicenter clinical trials have provided consistent evidence that implantable defibrillation therapy prolongs patient life. This convincing demonstration of the efficacy of defibrillation has led to a nearly exponential growth, over the last decade, in the number of patients receiving implantable devices.The current wide application of defibrillation raises new concerns regarding the safety and optimization of the therapy. Improved understanding of defibrillation mechanisms is therefore",{"id":809,"funder":7,"programme":8,"title":810,"piName":10,"institution":790,"country":45,"year":13,"amount":811,"abstract":812},"cordis-marie-skłodowska-curie-actions-award-22935","Catenanes and Rotaxanes - From Topological Chemistry to Molecular Machines","€112,537","Mechanically interlocked molecules such as catenanes and rotaxanes constitute a major research field of supramolecular chemistry. We propose the synthesis and characterization of a cyclic [3]-catenane and a molecular shuttle that is based on a rotaxane assembly.In the past few years, an increasing number of [2]-catenanes have been reported; but very little work has been done on the more challenging [3]-catenane systems in which three molecular rings are mechanically interlocked.Such systems are ",{"id":814,"funder":7,"programme":8,"title":815,"piName":10,"institution":19,"country":12,"year":13,"amount":144,"abstract":816},"cordis-marie-skłodowska-curie-actions-award-24841","Characterisation of GABAergic interneurons in the amygdala of GAD65-GFP transgenic mice","Understanding the neuronal mechanisms mediating emotional information processing in the amygdala will require identification of its main cell types and knowledge of their participation in the intrinsic circuitry of this region. Amygdala pyramidal neurons a re spiny projection neurons that use glutamate as an excitatory neurotransmitter.In contrast, most non-pyramidal neurons in the amygdala are aspiny interneurons that use GABA as an inhibitory neurotransmitter. Very few studies linking physiolo",{"id":818,"funder":7,"programme":8,"title":819,"piName":10,"institution":295,"country":45,"year":13,"amount":820,"abstract":821},"cordis-marie-skłodowska-curie-actions-award-24620","Spatio-temporally complex tactile stimuli processing in rat barrel cortex.","€160,486","We have a comprehensive understanding of how the brain reacts to simple sensory stimuli but we are only starting to explore the way sensory systems respond to complex natural stimuli. The vibrissal system of the rodent is one of the dominant models for investigating sensory information processing. Neurons in the vibrissal cortical representation have extended subthreshold receptive fields (RF). This suggests that rat barrel cortex has broad cortico-cortical connections that provide a substrate f",{"id":823,"funder":7,"programme":8,"title":824,"piName":10,"institution":825,"country":332,"year":13,"amount":826,"abstract":827},"cordis-marie-skłodowska-curie-actions-award-21871","Aspects of holonomy, decoupling and reduction of Lagrangian systems","GHENT UNIVERSITY","€248,339","The mathematical theory of dynamical systems provides models for a large variety of phenomena in different areas of science. In this project, we will study the subclass of Lagrangian systems (including systems with non-holonomic constraints), but with an emphasis on rather pure geometrical aspects and methods. Although the starting point will be problems of quite practical interest in applied mathematics, namely the characterization of partial or full decoupling into substructures of regular Lag",{"id":829,"funder":7,"programme":8,"title":830,"piName":10,"institution":831,"country":45,"year":13,"amount":774,"abstract":832},"cordis-marie-skłodowska-curie-actions-award-38768","Set theoretic methods in analysis","UNIVERSITE PARIS 7 DENIS DIDEROT","In this project we propose to use set-theoretic methods in order to study two sets of problems coming from functional analysis. The first concerns with the problem of the continuous images of Radon-Nikodym compact spaces posed by Namioka some thirty years ago. This class of compacta has been isolated in the early 1970 and apos;s in the course of studying a Radon-Nikodym property of vector measures. Particularly useful was the characterization in terms of Frechet differentiability leading to a pu",{"id":834,"funder":7,"programme":8,"title":835,"piName":10,"institution":836,"country":12,"year":13,"amount":837,"abstract":838},"cordis-marie-skłodowska-curie-actions-award-21198","Semi-classical dynamics on large systems using the MMVB method: Applications to photochemical switches and electron transfer systems","IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE","€160,294","The aim of this proposal is the study of the complex long-time dynamics of molecular switches and electron transfer systems. It will be achieved by the development of a hybrid approach allowing for highly accurate simulations on large chemical, biological and physical systems due to combination of quantum description for reactive center and classical force fields for surrounding molecular framework. The hybrid MM-VB (Molecular Mechanics ¿ Valence Bond) method which is proven to be a useful tool ",{"id":840,"funder":7,"programme":8,"title":841,"piName":10,"institution":842,"country":58,"year":13,"amount":843,"abstract":844},"cordis-marie-skłodowska-curie-actions-award-38959","Studies of magnetic dipole-dipole interactions in a Chromium Bose-Einstein Condensate","UNIVERSITäT STUTTGART","€157,063","A Bose-Einstein Condensate (BEC) in chromium (Cr) has been created recently. Compared to other species, Cr has two assets: it can be used for lithography, and, due to its large magnetic moment, the long-range, anisotropic magnetic dipole-dipole interaction (MDDI) is comparable to the contact interaction usually at work in standard BECs. MDDI is of general interest as it provides the cold atoms community with a new tool in the interdisciplinary field of quantum engineering. MDDI is intermediate b",{"id":846,"funder":7,"programme":8,"title":847,"piName":10,"institution":848,"country":45,"year":13,"amount":849,"abstract":850},"cordis-marie-skłodowska-curie-actions-award-21744","Study of CP Violation and Flavour Structure as a Probe of Physics beyond the Standard Model","UNIVERSITé PARIS-SUD","€148,579","CP violation and flavour changing phenomena provide an unique window to physics beyond the Standard Model. Our main goal is to extract information about new particles, for instance the super-partners of quarks (squarks) predicted by the super-symmetric ( SUSY) extension of the Standard Model (SM), by fully taking advantage of the data from B meson experiments (Babar, Belle, LHCb). Being the world highest luminosity machines, these experiments are able to observe extremely rare B decays, in which",{"id":852,"funder":7,"programme":8,"title":853,"piName":10,"institution":854,"country":65,"year":13,"amount":855,"abstract":856},"cordis-marie-skłodowska-curie-actions-award-25369","Influence of sexual hormones and health status on the expression of carotenoid-based colouration","UNIVERSITY OF GRONINGEN, RESEARCH GROUP BEHAVIOURAL BIOLOGY","€157,192","I propose to study the importance of estrogens in the control of carotenoid based sexual ornamentation in the common kestrel and in zebra finch.Since carotenoids participate in maintaining the health status (e.g. immunostimulation and antioxidant activity) it is plausible that there should be a trade-off between the signalling function and other functions useful for the organism (which require the availability of carotenoids in other tissues of the body).For this reason several important health ",{"id":858,"funder":7,"programme":8,"title":859,"piName":10,"institution":295,"country":45,"year":13,"amount":860,"abstract":861},"cordis-marie-skłodowska-curie-actions-award-24710","Towards a non-critical non-AdS\u002Fnon-CFT correspondence","€151,982","In the last few years many important successes have been achieved in the understanding of string theory and its relation to large N gauge theories. The AdS-CFT proposal is the best understood example of such holographic dualities. Since its original propos al, many steps have been taken to extend this duality and build the string theory dual of (large N) QCD, but a satisfactory and complete model is still a long way to come. It is plausible that the dual of QCD involves a non-critical five-dimen",{"id":863,"funder":7,"programme":8,"title":864,"piName":10,"institution":865,"country":45,"year":13,"amount":866,"abstract":867},"cordis-marie-skłodowska-curie-actions-award-23943","Gradient linguistic intuitions cross-linguistically","UNIVERSITE CHARLES DE GAULLE LILLE 3","€206,652","The research aims at establishing the importance of robust experimental methodology for the reliable elicitation of acceptability judgements, the basis of modern linguistic theory. It extends standard methodological practice in comparative linguistics wit h a psycholinguistic experimental methodology that allows objective cross-linguistic comparisons, necessary for identifying linguistic universals and the locus of cross-linguistic variation.The research will focus on the gradient nature of ling",{"id":869,"funder":7,"programme":8,"title":870,"piName":10,"institution":836,"country":12,"year":13,"amount":871,"abstract":872},"cordis-marie-skłodowska-curie-actions-award-25108","The origin of the cosmic X-ray background: bridging observations with theory","€222,522","Since its discovery 40 years ago, the origin of the diffuse cosmic X-ray background radiation, that fills every direction on the Sky, remains a mystery.Despite significant progress in the field, recent surveys using the largest X-ray telescopes currently available, suggest large discrepancies between observations and model predictions with regards to the nature of the extragalactic populations responsible for the X-ray background.This proposal has the ambitious but realistic goal to bridge this ",{"id":874,"funder":7,"programme":8,"title":875,"piName":10,"institution":876,"country":388,"year":13,"amount":877,"abstract":878},"cordis-marie-skłodowska-curie-actions-award-21421","Gravity, Chern-Simons extensions, Topology and Solid-state Physics applications","VIENNA UNIVERSITY OF TECHNOLOGY","€262,360","Advances in mathematics and physics have often occurred together - the development of Newton's theory of mechanics and the simultaneous development of the techniques of calculus constitute a classic example of this phenomenon. A more recent one is provided by topology on the mathematical side and (quantum) theory of fields in physics. Scientifically, this project is devoted to a novel approach to incorporate topological invariants, in particular the so-called Chern-Simons term, in gravitational ",{"id":880,"funder":7,"programme":8,"title":881,"piName":10,"institution":882,"country":45,"year":13,"amount":883,"abstract":884},"cordis-marie-skłodowska-curie-actions-award-24173","Non conformal field theories and dual string solutions","UNIVERSITE DE PARIS 6 PIERRE ET MARIE CURIE","€77,125","The theory of strings interacting on curved backgrounds is expected to provide a description of the dynamics of realistic quantum field theories. We are still very far from reaching this goal, but remarkable results have been obtained confirming the validity of the string\u002Fgauge theory correspondence in a lot of interesting super-symmetric and\u002For conformal models.The present project aims to give a contribution to the study of the correspondence in a large class of new non- trivial models. It will",{"id":886,"funder":7,"programme":8,"title":887,"piName":10,"institution":888,"country":12,"year":13,"amount":889,"abstract":890},"cordis-marie-skłodowska-curie-actions-award-24154","Integrability in conformal field theory and beyond.","UNIVERSITY OF YORK","€163,696","The mathematical physics research group at York is internationally recognized for its fundamental contributions to the theory of integrable systems.The researcher Boris Noyvert has worked for 8 years in conformal field theory and the theory of infinite di mensional algebras. At York he will establish a connection of his previous research to the theory of integrable systems. He will study the applications of conformal field theory to integrable models and the integrability phenomenon beyond confo",{"id":892,"funder":7,"programme":8,"title":893,"piName":10,"institution":894,"country":12,"year":13,"amount":895,"abstract":896},"cordis-marie-skłodowska-curie-actions-award-39189","Cosmological challenges in theories of extra dimensions","UNIVERSITY OF PORTSMOUTH","€152,242","The conjecture that there exist in nature extra (i.e. more than four) dimensions, is well motivated theoretically and promises surprising experimental signatures when the extra dimensions and quot;open up and quot;. Liberating our universe from four dimensions, offers new perspectives to long-standing problems of high-energy physics and cosmology. My research project will focus on three areas of interest in the cosmology of extra dimensions. Firstly, I will study the explanation of the smallness",{"id":898,"funder":7,"programme":8,"title":899,"piName":10,"institution":900,"country":58,"year":13,"amount":901,"abstract":902},"cordis-marie-skłodowska-curie-actions-award-22594","Infinite graphs, ends, their topology, and totally disconnected groups","UNIVERSITAET HAMBURG","€141,784","We build a new axiomatic end theory for non-locally compact spaces (such as non-locally finite graphs) as a generalization of Freudenthal's end theory. A theorem of Hopf which determines the structure of the end space by groups acting with small fundamental domains shall be generalized and extended. We deal with questions concerning the cycle spaces of graphs which link combinatorial graph theory and end theory. Furthermore, we compare directions of the action of totally disconnected topological",{"id":904,"funder":7,"programme":8,"title":905,"piName":10,"institution":295,"country":45,"year":13,"amount":906,"abstract":907},"cordis-marie-skłodowska-curie-actions-award-39962","Gauge theories, cosmology and holography","€153,682","Investigation of confining gauge theories by employing recently developed techniques in the gauge-gravity duality constitutes the first part of this proposal.The technique of gamma-deformations in the context of gauge-gravity duality (Lunin an Maldacena) provides a new tool to distinguish and examine the universal aspects of non-perturbative gauge dynamics in the gravity duals (Gursoy and Nunez).This fact raises hopes to understand the non-perturbative gauge dynamics by studying supergravity in ",{"id":909,"funder":7,"programme":8,"title":910,"piName":10,"institution":586,"country":45,"year":13,"amount":911,"abstract":912},"cordis-marie-skłodowska-curie-actions-award-22006","Specification of Arterial Venous Identity in Embryonic Stem Cells","€150,804","During embryonic development, formation of a functional cardiovascular system is critical for survival. When genes essential for cardiovascular development are ablated, embryos die by mid-gestation. Interestingly, this includes ablation of genes for arterial-venous (AV) differentiation indicating that arteries and veins are specified very early in development and that this specification is essential for proper cardiovascular function. AV identity was originally believed to be a trait acquired th",{"id":914,"funder":7,"programme":8,"title":915,"piName":10,"institution":19,"country":12,"year":13,"amount":120,"abstract":916},"cordis-marie-skłodowska-curie-actions-award-21308","Nuclear organisation in the regulation of Hox gene clusters","The correct temporal and spatial patterns of gene expression of Hox genes are necessary for patterning of the developing embryo. Intriguingly, the time and place of Hox gene expression is collinear with the order of the genes on the chromosome. However, t he molecular mechanisms underlying this exquisite gene regulation are poorly understood. In cell culture, the sequential activation of mouse HoxB genes correlates with a visible unfolding of chromatin structure, and a re-localisation of active ",{"id":918,"funder":7,"programme":8,"title":919,"piName":10,"institution":920,"country":58,"year":13,"amount":921,"abstract":922},"cordis-marie-skłodowska-curie-actions-award-41951","Structural characterization of YidC, a novel component of the membrane proteins translocation machinery","RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG","€148,020","Understanding membrane protein biogenesis is of central importance for modern society as membrane proteins are not only crucial for transport or acting as receptors, they also comprise a major drug target for phamaceutical industry. In E. coli membrane protein biogenesis requires components of the well- described SRP and Sec pathways for targeting to and insertion into the membrane. However, a clear picture of the integration of membrane proteins into the lipid bilayer has not yet emerged. Recen",{"id":924,"funder":7,"programme":8,"title":925,"piName":10,"institution":456,"country":45,"year":13,"amount":926,"abstract":927},"cordis-marie-skłodowska-curie-actions-award-41847","High angular resolution imaging of extra-solar planetary systems with the very large Telescope Interferometer","€151,414","The 170 extra-solar giant planets discovered by indirect methods in the past 10 years have considerably changed our understanding of how planetary systems form and evolve. In order to investigate the composition of these planets and the physics of their atmospheres, direct imaging is now necessary, but faces two main challenges: the very small angular separation and the huge contrast between the planets and their parent stars. The same challenges apply to the study of circumstellar debris disks,",{"id":929,"funder":7,"programme":8,"title":930,"piName":10,"institution":931,"country":58,"year":13,"amount":932,"abstract":933},"cordis-marie-skłodowska-curie-actions-award-25860","Structural and functional analysis of nematode Lipid Binding Proteins (LBPs) from the chicken parasite Ascaridia galli","EUROPEAN MOLECULAR BIOLOGY LABORATORY","€147,454","Bio-based agricultural production has increased in recent years and, partly in consequence, parasitic infections in free-range poultry have also increased. Ascaridiosis is one of the most widespread nematode infections of chickens and has economic impact on meat and egg production.Intensive chemoprophylaxis is no longer efficient due to the high level of chemical residues in the food products and the rapid development of drug resistant parasites. New treatments against ascaridiosis and other nem",{"id":935,"funder":7,"programme":8,"title":936,"piName":10,"institution":937,"country":364,"year":13,"amount":938,"abstract":939},"cordis-marie-skłodowska-curie-actions-award-23053","Effects of pulse events at different spatial and temporal scales on stream ecosystems","EIDGENOESSISCHE ANSTALT FUER WASSERVERSORGUNG, ABWASSERREINIGUNG UND GEWAESSERSCHUTZ","€184,022","The primary objective of the project is to investigate the effect of spatial and temporal scales on the ecosystem response to flow pulse events. Flooding and drying episodes influence ecosystem dynamics at multiple spatial and temporal scales. Ecosystem processes like nutrient cycles and carbon fluxes are differentially shaped at variable spatial scales by both flood events and droughts. Stream metabolism (primarily gross primary production and ecosystem respiration) will be used to evaluate eco",{"id":941,"funder":7,"programme":8,"title":942,"piName":10,"institution":191,"country":12,"year":13,"amount":943,"abstract":944},"cordis-marie-skłodowska-curie-actions-award-24740","Promoting reconciliation through youth: inter-ethnic community mobilization","€152,809","sphere",{"id":946,"funder":7,"programme":8,"title":947,"piName":10,"institution":948,"country":45,"year":13,"amount":949,"abstract":950},"cordis-marie-skłodowska-curie-actions-award-42148","Involvement of the tumour suppressor ING genes in lung cancer","INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE","€80,000","Lung cancer is the major cause of cancer deaths in Europe, and is claiming more deaths than breast, colon and prostate cancers combined. Early diagnosis allowing surgical resection with a 60 to 80% five years' survival is performed in less than 25% of the patients, stressing the need of identifying molecular biomarkers to improve early detection and therapies. Lung carcinogenesis is a multi-step process characterized by the accumulation of genetic alterations, due to exposure to carcinogens targ",{"id":952,"funder":7,"programme":8,"title":953,"piName":10,"institution":954,"country":955,"year":13,"amount":956,"abstract":957},"cordis-marie-skłodowska-curie-actions-award-41819","Conservation Marketing as a tool for the sustainable preservation of the Maltese cultural heritage","UNIVERSITY OF MALTA, FACULTY OF ECONOMICS, MANAGEMENT AND ACCOUNTANCY","MT","€130,504","One of the essential requirements for the effective heritage preservation is ensuring its sustainability. Achieving the latter depends to a large extent on a close interdisciplinary collaboration of professionals from different fields (conservators, architects, arts historians, lawyers, managers, economists et al.) This research project aims at supplementing the range of the fields' auxiliary to heritage preservation by the marketing science. In particular it aims at identifying marketing tools ",{"id":959,"funder":7,"programme":8,"title":960,"piName":10,"institution":961,"country":12,"year":13,"amount":962,"abstract":963},"cordis-marie-skłodowska-curie-actions-award-42213","Incomplete Markets and Monetary Policy","LONDON SCHOOL OF ECONOMICS AND POLITICAL SCIENCE","€114,465","Within almost all modern nations, special institutions (like the European Central Bank or the US Federal reserve) exist and have the task of maintaining the monetary policy of a country or transnational entity independently of executive government. In general, these institutions are called central banks and often have other responsibilities such as supervising the smooth operation of the financial system. Since no single model can contain all the mechanisms or channels that might be at work in t",{"id":965,"funder":7,"programme":8,"title":966,"piName":10,"institution":222,"country":45,"year":13,"amount":967,"abstract":968},"cordis-marie-skłodowska-curie-actions-award-21820","Electronic structure and magnetic properties of strongly correlated transition metal materials","€167,497","Materials with strong electronic Coulomb interactions are of great interest for industrial and technological applications due to their unusual properties, e.g. metal-insulator transitions, exotic magnetic properties etc.The overall subject of the present research project is:(1) to study the magnetic and electronic properties of strongly correlated materials from first principles and(2) the development\u002Fimprovement of the numerical and analytical tools for their description.The project aims at bri",{"id":970,"funder":7,"programme":8,"title":971,"piName":10,"institution":784,"country":45,"year":13,"amount":972,"abstract":973},"cordis-marie-skłodowska-curie-actions-award-24281","Role of the Nck adaptor proteins in adaptive immune responses","€1,554,403","The immune system has evolved to protect the organism from a variety of disease-causing agents, and to avoid harmful responses to self. A number of disorders develop in case of inappropriate immune responses: these include autoimmune diseases, allergy, tra nsplant rejection, as well as immuno-deficiencies and failure to eliminate developing tumors. Current therapies lack specificity and cause dangerous side-effects. A better understanding of the molecular mechanisms underlying immune tolerance a",{"id":975,"funder":7,"programme":8,"title":976,"piName":10,"institution":977,"country":58,"year":13,"amount":978,"abstract":979},"cordis-marie-skłodowska-curie-actions-award-40519","The contraction method for random recurrences, and probabilistic analysis of algorithms","JOHANN WOLFGANG GOETHE-UNIVERSITÄT FRANKFURT AM MAIN","€151,393","This research is aimed at the probabilistic analysis of 'divide-and-conquer' algorithms, which include fundamental examples such as quicksort, partial match queries on k-d trees, and multiple selection.In order to gain a detailed understanding of such algorithms, a fine stochastic analysis is needed which may include higher order moments, concentration around the mean and in the best base, a limiting distribution.The contraction method, introduced by Rosler in 1991, was the first method capable ",{"id":981,"funder":7,"programme":8,"title":982,"piName":10,"institution":983,"country":32,"year":13,"amount":984,"abstract":985},"cordis-marie-skłodowska-curie-actions-award-10403","Nuclear thermo-dynamics","LABORATORI NATIONALI DEL SUD, ISTITUTO DI FISICA NUCLEARE","€151,853","The statistical multifragmentation model (A. H. Raduta et al.) will be improved such as to take into account the fragment deformation degrees of freedom and to acheive realistic features specific to dynamical simulations. The modification is supposed to r estore the van der Waals shape of the nuclear phase diagram calculated via statistical models. The new version of the model and results of dynamical simlations at frezee-out will be comparatively applied in all evaluations thus contributing to ",{"id":987,"funder":7,"programme":8,"title":988,"piName":10,"institution":989,"country":364,"year":13,"amount":990,"abstract":991},"cordis-marie-skłodowska-curie-actions-award-40198","Understanding Wetland occupation in prehistoric Europe","UNIVERSITÄT BASEL","€173,832","Wetland environments were often preferred for the location of permanent settlements in prehistoric times. This could be for many reasons: use of local resources, ease of erecting timber houses, or defence.Such a pattern of lakeside settlement began early (4th millennium BC) in the circum-Alpine region of Europe, where it has been intensively investigated, especially because of its exceptional preservation of organic finds, and the opportunity to reconstruct its environmental setting and response",{"id":993,"funder":7,"programme":8,"title":994,"piName":10,"institution":995,"country":45,"year":13,"amount":996,"abstract":997},"cordis-marie-skłodowska-curie-actions-award-022018","Community based ecotourism, conservation of biodiversity and land management","UNIVERSITÉ PAUL VALÉRY- MONTPELLIER III","€272,372","The goal of the research project is to study in which way native communities are inspired by visions of sustainability in the development of ecotourism related activities in their land management practice, the conservation of biological diversity and the revival and\u002For the preservation of their cultural integrity. The focus on indigenous people is very timely as donors are getting more concerned by social equity and property rights issues in developing countries. At the EU level, the associate c",{"id":999,"funder":7,"programme":8,"title":1000,"piName":10,"institution":1001,"country":45,"year":13,"amount":1002,"abstract":1003},"cordis-marie-skłodowska-curie-actions-award-40070","Constraints on the extent and timing of glaciations, and tectonics, in South Central Tibet, using cosmogenic radionuclide dating methods","INSTITUT DE PHYSIQUE DU GLOBE DE PARIS","€250,231","The extent and timing of glaciations in the interior of the Tibetan Plateau provides important information about recent climate changes in this area, and offset glacial deposits place important constraints on tectonic rates along strike-slip and normal faults in the Plateau.In particular, the reconstruction and dating of the former extent of glaciers is essential for paleoclimatic modeling that are used to predict future climate change. In addition, glacial deposits have been used to constrain t",{"id":1005,"funder":7,"programme":8,"title":1006,"piName":10,"institution":1007,"country":102,"year":13,"amount":1008,"abstract":1009},"cordis-marie-skłodowska-curie-actions-award-21673","Iberian high-resolution terrestrial archives: timing and mechanisms of abrupt climate change during the Holocene","CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS","€213,412","This proposal intends to analyse the structure and timing of selected periods of abrupt climate change in the northern Iberian Peninsula during the Holocene based on high-resolution terrestrial records. A scientific strategy has been designed to identify, analyse and evaluate the previously observed and described periods of abrupt climate change. The feasibility of the main goals of the project is assured by the availability of exceptional high-resolution lacustrine cores and speleothems from no",{"id":1011,"funder":7,"programme":8,"title":1012,"piName":10,"institution":1013,"country":58,"year":13,"amount":474,"abstract":1014},"cordis-marie-skłodowska-curie-actions-award-40846","The multi-proxy study of Chilean fjord sediments: a high-resolution record of climate variability in South America since the end of the last glacial maximum","ALFRED-WEGENER-INSTITUT FÜR POLAR- UND MEERESFORSCHUNG","Several recent studies have demonstrated that climate records from Antarctic ice cores are clearly asynchronous with the rapid changes of the Northern Hemisphere. However, paleoclimate data from the rest of the Southern Hemisphere yield conflicting interpretations of interhemispheric synchrony\u002Fasynchrony of the climate system. In order to better understand the paleoclimate relationships between the Northern and Southern hemispheres, high-resolution and well-dated paleoclimate data from key-locat",{"id":1016,"funder":7,"programme":8,"title":1017,"piName":10,"institution":836,"country":12,"year":13,"amount":1018,"abstract":1019},"cordis-marie-skłodowska-curie-actions-award-40623","From Stochastic processes to mathematical finance: learning to translate real-life financial challenges into mathematics and solve them applying modern probability theory","€151,676","The proposal aims to establish Jan Obloj as an active researcher in mathematical finance. He is to master the new domain, which provides ideal applied counterpart to his theoretical research experience. The Fellowship will lead to articles in world-class journals and long-term projects and collaborations.The field of mathematical finance is a cutting edge domain of applied mathematics. It is an increasingly important multi-disciplinary field involving business, finance, banking and assurance iss",{"id":1021,"funder":7,"programme":8,"title":1022,"piName":10,"institution":1023,"country":712,"year":13,"amount":1024,"abstract":1025},"cordis-marie-skłodowska-curie-actions-award-21357","Identification of genes controlling the innate immune response in mosquitoes infected with the malaria parasite, Plasmodium","UNIVERSITY OF CRETE","€142,542","This project aims at the identification of the genes controlling the innate immune response in mosquitoes infected with the malaria parasite, Plasmodium. There is ample evidence that mosquitoes and the malaria parasite have co-evolved and that the immune system of the mosquito greatly affects the ability of the parasite to undergo rather complex development in the insect. A large number of genes are involved in insect immunity, most of which have been identified in Anopheles gambiae. In order to",{"id":1027,"funder":7,"programme":8,"title":1028,"piName":10,"institution":1029,"country":12,"year":13,"amount":1030,"abstract":1031},"cordis-marie-skłodowska-curie-actions-award-21859","Asymptotics of stochastic dynamical systems","HERIOT-WATT UNIVERSITY","€106,669","The proposed research will be concerned with applications of large deviations in areas of stochastic dynamical systems that exhibit discontinuities due to sudden changes in their parameters or due to the presence of heavy-tailed probability distributions. The goal is the understanding and analysis of the behaviour of these complex systems in time (focusing mostly in stability analysis) as well as in space (random graph models possessing nodes with a gigantic number of neighbours being a principa",{"id":1033,"funder":7,"programme":8,"title":1034,"piName":10,"institution":295,"country":45,"year":13,"amount":497,"abstract":1035},"cordis-marie-skłodowska-curie-actions-award-42047","Metastable Helium Condensates in optical Lattices: kinetics of the Mott-insulator transition","The German applicant achieved his Dipl.Phys. at the University of Hannover, working on magneto-optical trapping of 85Rb with Prof.W.Ertmer. He has graduated to doctor of the University of Amsterdam in the group of Prof.J.T.M.Walraven, where he developed scientific expertise in collisional and collective behaviour of ultra-cold thermal clouds and Bose-Einstein condensation (BEC) of 87Rb. He now plans a project within the cold atom group at LKB\u002FENS in Paris. His program, elaborated with Prof.M.Led",{"id":1037,"funder":7,"programme":8,"title":1038,"piName":10,"institution":1039,"country":332,"year":13,"amount":1040,"abstract":1041},"cordis-marie-skłodowska-curie-actions-award-25124","Design of secure stream ciphers","KATHOLIEKE UNIVERSITEIT LEUVEN","€81,442","A cipher is considered secure if it is resistant against all known attacks, and, in the same time, it satisfies a set of statistical tests (linear complexity, universal Mauer test, frequency test, run test, etc).This project deals with both key recovery attacks and statistical tests for stream ciphers. More specifically, we will investigate one of the most promising techniques for attacking a stream cipher, the algebraic attack, and a statistical test for pseudo-randomness evaluation, the minimu",{"id":1043,"funder":7,"programme":8,"title":1044,"piName":10,"institution":1045,"country":58,"year":13,"amount":1046,"abstract":1047},"cordis-marie-skłodowska-curie-actions-award-514844","Approximation of Turkish legal provisions in the field of consumer contracts to EU Law","RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG","€151,394","The subject of the present research project will be the Approximation of Turkish Legislation in the Field of Consumer Contracts to Community Law. Since February 1995 Turkey has been making every effort to approximate its legislation to EC law as far as possible. In order to implement the directives on consumer protection, a skeleton consumer protection law was enacted in Turkey in September 1995. Though this law is an important first step in approximating Turkish legislation to the provisions of",{"id":1049,"funder":7,"programme":8,"title":1050,"piName":10,"institution":1051,"country":173,"year":13,"amount":1052,"abstract":1053},"cordis-marie-skłodowska-curie-actions-award-22276","Applications of Multi-user Information Theory to Data Hiding","TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY","€259,851","The basis of this proposal lies in the intersection between multi-user Information Theory and Information Hiding. Due to the dramatic increase in the use of digital data, its availability in the Internet and the ease at which data can be copied and stored, there is increased interest in data hiding schemes in their various applications, as reflected in the growing number of papers describing watermarking (WM) schemes and the emerging standards for practical systems. Watermarking is a form of hid",{"id":1055,"funder":7,"programme":8,"title":1056,"piName":10,"institution":1057,"country":1058,"year":13,"amount":1059,"abstract":1060},"cordis-marie-skłodowska-curie-actions-award-25885","Cellular and molecular dynamics of ectopic germinal centre formation in rheumatoid arthritis","FUNDACAO CALOUSTE GULBENKIAN","PT","€89,836","B lymphocytes are key effector cells in adaptive immune responses against foreign antigens, by producing antibodies and processing and presenting the antigen to T lymphocytes. In healthy individuals B lymphocyte differentiation and maturation takes place in the germinal centres of peripheral lymphoid organs.However, in chronic inflammatory autoimmune diseases (e.g. rheumatoid arthritis, Sjogren syndrome) ectopic germinal centres develop at the sites of inflammation, allowing an (auto)antigen dep",{"id":1062,"funder":7,"programme":8,"title":1063,"piName":10,"institution":1064,"country":65,"year":13,"amount":1065,"abstract":1066},"cordis-marie-skłodowska-curie-actions-award-7340","From density matrix functionals to exchange-correlation functionals in density functional theory","VRIJE UNIVERSITEIT","€76,328","The failures of the current Kohn-Sham density functional theory (KS DFT) implementations severely limit their usefulness in modelling of chemical phenomena. Since they are inherent to functionals that express the KS exchange-correlation energy as an integral of a simple function of the electron density and its derivatives, a careful investigation of various alternatives to the conventional KS formalism that retain its low computational cost while improving the description of and unusual and spec",{"id":1068,"funder":7,"programme":8,"title":1069,"piName":10,"institution":179,"country":12,"year":13,"amount":1070,"abstract":1071},"cordis-marie-skłodowska-curie-actions-award-24077","Asymmetric Baylis Hillman reaction","€228,760","In this project, we report a novel approaches to the asymmetric Baylis-Hillman (BH) reactions. The study (scope and limitations) of this new variant of the B-H reaction, leads the way to the development of a useful and broadly applicable methodology in the future. In this way, we propose a new strategy for the design of chiral catalysts derived from Proline, with the aim to develop a catalytic asymmetric version of the Baylis-Hillman reaction.",{"id":1073,"funder":7,"programme":8,"title":1074,"piName":10,"institution":1075,"country":58,"year":13,"amount":1076,"abstract":1077},"cordis-marie-skłodowska-curie-actions-award-16333","Developing and integrating novel technologies to improve safety, transparency and quality insurance of the chilled\u002Ffrozen food supply chain","VEREIN ZUR FÖRDERUNG DES TECHNOLOGIETRANSFERS AN DER HOCHSCHULE BREMERHAVEN E.V","€10,104,558","The consumption of chilled and frozen food products within Europe is growing above average (growth rates >10%) due to changes in society whereas food safety and control are of great concern for consumers. With 11 million tons consumed per year, the Euro pean Union is the second largest market for chilled and frozen food products. The reinforcement of confidence in chilled food products, especially regarding supply-chain aspects, is of high priority for all involved in food manufacturing, trade, ",{"id":1079,"funder":7,"programme":8,"title":1080,"piName":10,"institution":375,"country":12,"year":13,"amount":1081,"abstract":1082},"cordis-marie-skłodowska-curie-actions-award-39755","The behaviour of random discrete structures at criticality","€164,829","Our primary research focus will be the behaviour of random discrete structures, with an emphasis on random graphs and percolation clusters. We will investigate the internal behaviour of such structures in the critical case - the moment when a large cluster emerges.In particular, we will investigate such questions as the cluster sizes, robustness of connectivity, and shortest paths between vertices in the same cluster. Such questions have been well-studied in both sub- and supercritical settings,",{"id":1084,"funder":7,"programme":8,"title":1085,"piName":10,"institution":1086,"country":388,"year":13,"amount":1087,"abstract":1088},"cordis-marie-skłodowska-curie-actions-award-21532","Advanced vision based concurrent mapping and localization","GRAZ UNIVERSITY OF TECHNOLOGY","€77,242","We consider vision-based navigation of a mobile agent (e.g. an autonomous robot or a wearable device) within an unknown, possibly wide environment. A wandering scenario is assumed, in which the agent often returns to places, which have been visited before, so that concurrent localization and mapping is required.Although the focus of the proposal is on computer vision, we are also interested in robust fusion with inertial and other sensors. Due to huge computational complexity, real time applicat",{"id":1090,"funder":7,"programme":8,"title":1091,"piName":10,"institution":1092,"country":58,"year":13,"amount":1093,"abstract":1094},"cordis-marie-skłodowska-curie-actions-award-22244","Prosthetic Limb Design and Control based on Gait Templates","FRIEDRICH-SCHILLER UNIVERSITY JENA","€239,546","The EU declared 2003 the `European Year of People with Disabilities¿ to increase the awareness about the situation of its millions of disabled citizens. Currently, it is estimated that at least 10% of the EU population will be affected by a disability. Fa cing such numbers and considering the current-state-of-the-art, improving the functionality of leg prostheses has developed into a research area of critical importance. The proposed MC OIF project ¿Lower Limb Prostheses Design and Control based",{"id":1096,"funder":7,"programme":8,"title":1097,"piName":10,"institution":1098,"country":1099,"year":13,"amount":1100,"abstract":1101},"cordis-marie-skłodowska-curie-actions-award-40371","New bounds for automorphic L-functions","ALFRED RENYI INSTITUTE OF MATHEMATICS, HUNGARIAN ACADEMY OF SCIENCES","HU","€108,988","Number theory is among the oldest and most central disciplines in mathematics. It has truly fascinating connections to algebraic geometry, combinatorics, ergodic theory, representation theory, and mathematical physics. Many of these connections as well as deep intrinsic properties are formulated in the language of L-functions.An important task is to establish subconvex bounds for automorphic L-functions. Such bounds reflect the arithmetic nature of their source objects as they cannot be derived ",{"id":1103,"funder":7,"programme":8,"title":1104,"piName":10,"institution":31,"country":32,"year":13,"amount":1105,"abstract":1106},"cordis-marie-skłodowska-curie-actions-award-39866","Evolution and fairness in the theory of monetary integration","€136,375","My research project aims to elaborate a theory of monetary integration as an evolutionary process in which countries care about fairness and reciprocity.Recent studies have shown that the optimum currency area (OCA) theory- fails to explain countries decisions regarding their participation to the European Monetary Union (EMU), and- has little or no predictive or explanatory capacity.This calls for the need of an approach bringing new lights on the decisions processes and taking into account the ",{"id":1108,"funder":7,"programme":8,"title":1109,"piName":10,"institution":1110,"country":65,"year":13,"amount":308,"abstract":1111},"cordis-marie-skłodowska-curie-actions-award-24312","The linguistic and cognitive representation of motion events","MAX PLANCK GESELLSCHAFT ZUR FORDERUNG DES WISSENSCHAFTEN E.V. REPRESENTED BY THE MAX PLANCK INSTITUTE FOR PSYCHOLINGUISTICS","The study addresses the issue of the relation between language and cognition and seeks to assess whether language-specific patterns influence linguistic and cognitive activities across speakers of French and Polish. These languages differ in the way they encode two basic parameters associated with motion, Path and Manner: while Polish expresses Path in the prefix and Manner, obligatory, in the main verb [in-run, out-run], French tends to express Path in the main verb and Manner, optionally, in a",{"id":1113,"funder":7,"programme":8,"title":1114,"piName":10,"institution":1115,"country":32,"year":13,"amount":1116,"abstract":1117},"cordis-marie-skłodowska-curie-actions-award-25056","Development of a new method to increase the degrees of freedom of myoelectric upper-limb prostheses and construction of a new neuromuscular model to improve their controllability","SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO SANT'ANNA","€151,854","Prostheses are artificial replacements of body parts that have been removed, e.g., by amputation following a traumatic event or a disease. Currently, three types of prosthetic hands are commercially available;- cosmetic: passive devices with a simple aesthetic purpose,- body-powered: powered and controlled by body movements, generally by shoulder or back muscles, and- myoelectric: electrically powered and controlled by electromyographic signals, which are the weak electrical signals produced by ",{"id":1119,"funder":7,"programme":8,"title":1120,"piName":10,"institution":113,"country":102,"year":13,"amount":1121,"abstract":1122},"cordis-marie-skłodowska-curie-actions-award-23302","Reconstruction and generic automorphisms","€130,210","The project is on the borderline between model theory (mathematical logic) and permutation group theory (algebra), though ideas from other fields such as set theory and combinatorics are involved. The goal is to investigate the following question for a range of first order structures: if one knows the automorphism group Aut(M) of a countable first order structure M, how much is known about M?The question only makes sense in highly symmetric contexts, such as for omega-categorical structures. Wor",{"id":1124,"funder":7,"programme":8,"title":1125,"piName":10,"institution":1126,"country":45,"year":13,"amount":1127,"abstract":1128},"cordis-marie-skłodowska-curie-actions-award-21890","Development of novel nondestructive techniques to analyze food quality","ECOLE NATIONALE D'INGÉNIEURS DES TRAVAUX AGRICOLES","€215,157","Most analytical techniques used in quality control require isolation of the food component of interest. The original properties of the product are, therefore, destroyed during sample preparation and analysis. Oftentimes, such analyses are expensive, time consuming, and require sophisticated instrumentation, and hence are not suited for on-line quality control of food products. For on-line sensors, many physical principles have been checked, yet very few sensors having a meaningful correlation wi",{"id":1130,"funder":7,"programme":8,"title":1131,"piName":10,"institution":1132,"country":332,"year":13,"amount":1133,"abstract":1134},"cordis-marie-skłodowska-curie-actions-award-39889","Therapeutic role of different VEGF members on neuron and muscle degeneration","FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW","€73,144","Recent evidence suggests that members of the VEGF family may be of therapeutic value for neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS). Indeed, VEGF administration significantly improved the clinical outcome of animal models of A LS.To further define the role of VEGF in motoneuron degeneration and in preparation of clinical trials, this project will investigate whether the expression of VEGF by the skeletal muscle might affect muscle atrophy and neuromuscular junction ",{"id":1136,"funder":7,"programme":8,"title":1137,"piName":10,"institution":375,"country":12,"year":13,"amount":120,"abstract":1138},"cordis-marie-skłodowska-curie-actions-award-39126","Synthesis of naturally occurring anticancer agents by the Oxidative Spirocyclisation of Furans","The aim of this research is to apply organic synthetic methodology developed in the Robertson group to the synthesis of natural products and their analogues that are known to possess, or have the potential to possess, anticancer activity. The target compounds are all oxygen heterocycles that will be assembled by an oxidative spiro-cyclisation process from furan derivatives.",{"id":1140,"funder":7,"programme":8,"title":1141,"piName":10,"institution":1039,"country":332,"year":13,"amount":1142,"abstract":1143},"cordis-marie-skłodowska-curie-actions-award-24001","The Consistent Solvency Model for the insurance undertakings in the European Single Insurance Market","€137,216","The project CONSOL-M focuses on the solvency requirements of the insurance undertakings functioning within the European Single Insurance Market (ESIM). Currently the solvency of an insurer is examined by the supervision authority only in relation to the qu antifiable risks, i.e. financially measurable risks (= a solvency margin on top of the technical provisions). The other risk categories (the qualitative risks) such as the capital investment risk, the corporate governance risk, the internal co",{"id":1145,"funder":7,"programme":8,"title":1146,"piName":10,"institution":1147,"country":58,"year":13,"amount":1148,"abstract":1149},"cordis-marie-skłodowska-curie-actions-award-515632","DefCrust","REINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN","€156,496","Many recent developments in our understanding of deformation in the Earth's crust come from geodynamic models which incorporate the geometries, boundary conditions and rock rheologies in the subsurface. Unfortunately, the rheology of rocks deforming under natural conditions is poorly known. Currently there are two approaches to quantify crustal rheology. The first approach extrapolates laboratory-derived flow laws for monomineralic materials over several orders of magnitude and the second approa",{"id":1151,"funder":7,"programme":8,"title":1152,"piName":10,"institution":1153,"country":65,"year":13,"amount":1154,"abstract":1155},"cordis-marie-skłodowska-curie-actions-award-21927","Novel algebraic multigrid solver for real-life industrial applications","TECHNISCHE UNIVERSITEIT DELFT","€151,521","An important constraint on our ability to numerically simulate important physical processes is our ability to solve the linear and non-linear systems of equations that result from discretization of continuous mathematical models (partial differential equations). A useful computational model of a physical process is one that is accurate (includes features and scales that are important to the scientific goals) and that can be solved efficiently (acceptable computational solution time on available ",{"id":1157,"funder":7,"programme":8,"title":1158,"piName":10,"institution":1001,"country":45,"year":13,"amount":1159,"abstract":1160},"cordis-marie-skłodowska-curie-actions-award-39503","Relating core-mantle interactions and the geomagnetic field","€151,938","The geomagnetic field is generated by fluid flow in the metallic liquid outer core, a process known as the geodynamo. Due to its current strength and mainly dipolar geometry, this field efficiently organizes the way particles flow in the vicinity of the Earth, preventing them from directly reaching the atmosphere. Currently however, the geomagnetic dipole decays 10 times faster than the free decay rate. Understanding the mechanisms responsible for this rapid evolution is then both a practical is",200,{"programme":8,"total":1163,"withPiName":1164,"firstYear":1165,"lastYear":1166,"countryCount":1167,"perYear":1168,"topInstitutions":1244,"topCountries":1320},26094,19,1988,2027,53,[1169,1171,1174,1177,1180,1182,1185,1188,1191,1194,1197,1200,1203,1206,1209,1212,1215,1218,1221,1224,1227,1230,1233,1236,1239,1242],{"year":1165,"count":1170},1,{"year":1172,"count":1173},2003,74,{"year":1175,"count":1176},2004,586,{"year":1178,"count":1179},2005,868,{"year":13,"count":1181},641,{"year":1183,"count":1184},2007,553,{"year":1186,"count":1187},2008,591,{"year":1189,"count":1190},2009,712,{"year":1192,"count":1193},2010,787,{"year":1195,"count":1196},2011,838,{"year":1198,"count":1199},2012,901,{"year":1201,"count":1202},2013,1005,{"year":1204,"count":1205},2014,1009,{"year":1207,"count":1208},2015,1232,{"year":1210,"count":1211},2016,1231,{"year":1213,"count":1214},2017,1209,{"year":1216,"count":1217},2018,1353,{"year":1219,"count":1220},2019,1340,{"year":1222,"count":1223},2020,1314,{"year":1225,"count":1226},2021,1688,{"year":1228,"count":1229},2022,1362,{"year":1231,"count":1232},2023,1495,{"year":1234,"count":1235},2024,1522,{"year":1237,"count":1238},2025,1781,{"year":1240,"count":1241},2026,1532,{"year":1166,"count":1243},396,[1245,1248,1251,1254,1257,1260,1263,1266,1269,1272,1275,1278,1281,1284,1287,1290,1293,1296,1299,1302,1305,1308,1311,1314,1317],{"name":1246,"count":1247},"Centre National de la Recherche Scientifique CNRS",790,{"name":1249,"count":1250},"The Chancellor Masters and Scholars of the University of Cambridge",636,{"name":1252,"count":1253},"Kobenhavns Universitet",614,{"name":1255,"count":1256},"Chancellor, Masters and Scholars of the University of Oxford",579,{"name":1258,"count":1259},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",484,{"name":1261,"count":1262},"Imperial College of Science Technology and Medicine",428,{"name":1264,"count":1265},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",383,{"name":1267,"count":1268},"University of London",347,{"name":1270,"count":1271},"Katholieke Universiteit Leuven",280,{"name":1273,"count":1274},"The University of Birmingham",247,{"name":1276,"count":1277},"Eidgenoessische Technische Hochschule Zuerich",224,{"name":1279,"count":1280},"Aarhus Universitet",220,{"name":1282,"count":1283},"Universita Ca' Foscari  Venezia",219,{"name":1285,"count":1286},"University of Bristol",213,{"name":1288,"count":1289},"Ecole Polytechnique Federale de Lausanne",182,{"name":1291,"count":1292},"The University of Edinburgh",181,{"name":1294,"count":1295},"Universita Degli Studi di Padova",177,{"name":1297,"count":1298},"Universitat Wien",175,{"name":1300,"count":1301},"University of Leeds",169,{"name":1303,"count":1304},"Universiteit van Amsterdam",159,{"name":1306,"count":1307},"Universitetet I Oslo",156,{"name":1309,"count":1310},"Universiteit Utrecht",152,{"name":1312,"count":1313},"Technische Universiteit Delft",142,{"name":1315,"count":1316},"University of Warwick",141,{"name":1318,"count":1319},"Institut National de la Sante Et de la Recherche Medicale",139,[1321,1323,1325,1327,1329,1331,1333,1335,1337,1339,1341,1343,1345,1347,1349,1351,1353,1355,1357,1360,1363,1366,1369,1371,1374],{"name":12,"count":1322},5982,{"name":45,"count":1324},2854,{"name":102,"count":1326},2844,{"name":58,"count":1328},2362,{"name":32,"count":1330},2058,{"name":65,"count":1332},1624,{"name":209,"count":1334},1173,{"name":364,"count":1336},1075,{"name":332,"count":1338},996,{"name":216,"count":1340},788,{"name":388,"count":1342},634,{"name":265,"count":1344},608,{"name":339,"count":1346},487,{"name":1058,"count":1348},482,{"name":246,"count":1350},313,{"name":712,"count":1352},277,{"name":427,"count":1354},256,{"name":173,"count":1356},168,{"name":1358,"count":1359},"TR",147,{"name":1361,"count":1362},"PL",137,{"name":1364,"count":1365},"SI",113,{"name":1367,"count":1368},"CY",99,{"name":1099,"count":1370},97,{"name":1372,"count":1373},"LU",59,{"name":1375,"count":1376},"LT",56]