[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-msca-postdoctoral-fellowship-2007":3,"awarded-stats-msca-postdoctoral-fellowship":1129},{"awarded":4,"total":1128},[5,16,23,30,37,43,49,55,62,67,73,79,84,90,97,104,110,115,122,128,134,141,147,152,157,162,168,173,180,187,194,200,206,211,215,221,226,232,238,245,251,258,263,269,275,280,286,293,299,304,309,314,319,324,330,336,342,347,353,359,365,371,376,382,389,395,400,405,410,416,420,425,429,434,439,445,451,456,461,467,474,480,486,493,499,504,510,515,521,526,531,537,542,547,552,558,563,569,574,579,585,590,596,600,605,610,614,618,623,628,634,640,647,651,657,663,667,673,678,684,688,692,698,704,708,713,719,725,731,737,741,745,750,755,760,765,770,776,782,788,794,800,806,812,817,823,828,834,839,844,850,855,860,866,871,878,884,890,895,901,907,913,919,924,929,934,938,943,948,954,960,966,972,977,983,988,993,997,1003,1009,1015,1020,1026,1032,1038,1044,1049,1055,1060,1066,1072,1077,1082,1088,1094,1100,1106,1111,1117,1123],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"cordis-marie-skłodowska-curie-actions-award-40000","Marie Skłodowska-Curie Actions","MSCA Postdoctoral Fellowship","Efficent synthesis of hemibrevetoxin B by deployment of new strategies for polyether construction",null,"UNIVERSITY OF GLASGOW","UK",2007,"€159,046","The proposed programme of research concerns the implementation of linear and two-directional strategies for the rapid total synthesis of the marine polyether natural product hemibrevetoxin B using novel ring-closing metathesis (RCM) methodology. Both of these approaches will employ catalytic RCM reactions of enol ethers, allylic ethers and alkynyl ethers that have been developed in the Clark Research Group in order to construct the cyclic ethers that are embedded in the fused tetracyclic structu",{"id":17,"funder":7,"programme":8,"title":18,"piName":10,"institution":19,"country":20,"year":13,"amount":21,"abstract":22},"cordis-marie-skłodowska-curie-actions-award-41243","Spin-liquid state in highly frustrated magnets: local studies","UNIVERSITE PARIS-SUD","FR","€119,514","Our project aims at an experimental study of novel phases and fundamental concepts in the field of strongly correlated magnetic systems, namely, fluctuating ground states generated by geometric frustration, a rapidly growing field, both from physics and chemistry aspects. Our research will focus on novel corner-sharing geometrically frustrated compounds. We will study in depth a recently discovered S = 1\u002F2 kagome compound, for which a resonating-valence-bond fluctuating ground state is predicted",{"id":24,"funder":7,"programme":8,"title":25,"piName":10,"institution":26,"country":27,"year":13,"amount":28,"abstract":29},"cordis-marie-skłodowska-curie-actions-award-46439","Transcriptional regulation of phagocytosis in macrophages","UNIVERSITY OF DEBRECEN","HU","€80,000","Macrophages are one of the most enigmatic cell types of our body. The regulation of the macrophage phagocytic activity is of utmost importance for a variety of processes, ranging from the formation and maintenance of tissues to the clearance of cellular debris. Yet little is known of the regulation of this process. Like those isolated from tissues, macrophages differentiated from monocytes ex vivo contain cells that don't show phagocytosis. We aim to develop methods to separate the fractions bas",{"id":31,"funder":7,"programme":8,"title":32,"piName":10,"institution":33,"country":34,"year":13,"amount":35,"abstract":36},"cordis-marie-skłodowska-curie-actions-award-39611","A customisable Middleware for building complex global computing Systems","SICS, SWEDISH INSTITUTE OF COMPUTER SCIENCE AB","SE","€151,212","The objective of this project is the design, implementation and evaluation of a middleware that provides search, specialisation, clustering, identity and topology adaptation services to enable the construction of complex, self-managing systems for use in areas such as service-oriented computing, i.e., a middleware for global computing systems.The project will contribute a modular middleware that can be customized to handle the diverse requirements of different global computing systems. The key r",{"id":38,"funder":7,"programme":8,"title":39,"piName":10,"institution":40,"country":12,"year":13,"amount":41,"abstract":42},"cordis-marie-skłodowska-curie-actions-award-41068","Person, individual rights and common goods in the EU; the case of social meanings of and quot;family and quot; and individual rights","UNIVERSITY COLLEGE LONDON","€161,994","The project is a philosophical reflection on some challenges faced by the EU in realising its ideal of unity in diversity. From the perspective of political theory, it asks how a political conception of the person and related social meanings and common goods are presupposed in the definition of fundamental rights. It explores the extent to which these may legitimately give rise to different sets of individual rights between various political communities (notably, the member states). While most s",{"id":44,"funder":7,"programme":8,"title":45,"piName":10,"institution":46,"country":12,"year":13,"amount":47,"abstract":48},"cordis-marie-skłodowska-curie-actions-award-40143","Heterocycle Transformations","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","€167,664","The aims of this research are to develop efficient synthetic methodology for catalytic enantioselective elaboration of heterocycles, and to eventually apply this methodology in strategies for the enantioselective synthesis of selected biologically important structural motifs.",{"id":50,"funder":7,"programme":8,"title":51,"piName":10,"institution":52,"country":53,"year":13,"amount":28,"abstract":54},"cordis-marie-skłodowska-curie-actions-award-46423","Inflation, dark energy and string theory","TEL-AVIV UNIVERSITY","IL","For decades it was believed that matter and radiation are the most dominant form of energy in the universe and that as a result the universe is decelerating. However, recent experiments show that the universe is actually accelerating and thus it is dominated by an unusual form of energy, known as dark energy.This form of energy induces a repulsive gravitational force which leads to the acceleration of the universe. Understanding dark energy from a particle physics perspective is a long-standing ",{"id":56,"funder":7,"programme":8,"title":57,"piName":10,"institution":58,"country":59,"year":13,"amount":60,"abstract":61},"cordis-marie-skłodowska-curie-actions-award-25110","Understanding the role of genes involved in phosphate transport and biological functions of the PSR1-related transcription factors in barley using Virus Induced Gene Silencing (VIGS) system","AARHUS UNIVERSITET","DK","€189,542","The project aims to use a multidisciplinary approach to study barley genes involved in phosphorus assimilation. Phosphorus (P) is an essential plant nutrient with numerous roles in plant growth and metabolism. Because phosphate (Pi), the form of P taken up by plants, is poorly accessible in most soils, plants have evolved an array of strategies for obtaining the Pi they need, including induction of high affinity Pi transporters, secretion of substances that can mobilize Pi bound in the soil, and",{"id":63,"funder":7,"programme":8,"title":64,"piName":10,"institution":46,"country":12,"year":13,"amount":65,"abstract":66},"cordis-marie-skłodowska-curie-actions-award-39739","Topological and analytic aspects of special Lagrangian singularities","€164,830","The first main objective of this proposal is to determine topological and Floer-theoretic obstructions to the existence of embedded Maslov-zero Lagrangian desingularizations of special Lagrangian (SL) cones. In particular, several such obstructions are expected to arise from the application of Contact homology techniques to the boundary of a neighbourhood of the singular point.The second main objective is to develop an analytic theory of singular, asymptotically conical, SL submanifolds: specifi",{"id":68,"funder":7,"programme":8,"title":69,"piName":10,"institution":70,"country":20,"year":13,"amount":71,"abstract":72},"cordis-marie-skłodowska-curie-actions-award-45987","European training courses and conferences in group theory (geometric, analytic and ergodic aspects of group theory)","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE","€466,545","This mathematics proposal, with group theory at its heart, covers an unusually diverse range of subjects: geometric group theory, harmonic analysis, operator algebras, ergodic theory, amenability, and random walks. These areas form the core of exciting new relationships and so a special effort must be made to encourage communication between experts and beginners in such diverse fields. To achieve this, we intend that participating young researchers attend all events, where international experts ",{"id":74,"funder":7,"programme":8,"title":75,"piName":10,"institution":76,"country":12,"year":13,"amount":77,"abstract":78},"cordis-marie-skłodowska-curie-actions-award-39362","Mothers know best? Fitness consequences and flexible adjustment of non-genetic inheritance in the zebra finch","THE CHANCELLOR, MASTER AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€158,479","The influence of the environment that mothers provide to their offspring in addition to their genes is an important determinant of the phenotype of an organism. These maternal effects are often interpreted as an adaptive adjustment of offspring phenotype b y which the mother enhances her own fitness. Most studies demonstrate this by showing positive consequences of the maternal effect for individual offspring. However, due to sibling competition, positive effects on one offspring may go at the c",{"id":80,"funder":7,"programme":8,"title":81,"piName":10,"institution":82,"country":12,"year":13,"amount":14,"abstract":83},"cordis-marie-skłodowska-curie-actions-award-41332","Nanoscale supramolecular assemblies: electrical and optical properties of single layer porphyrin assemblies","THE UNIVERSITY OF BIRMINGHAM","Molecules are potential building blocks for new optoelectronic devices. Much research is needed in order to understand how molecules with promising properties interact to form a higher order matter, and to be able to incorporate the self-assembled material into devices with interconnections to the macroscopic world. In this framework, we propose to study porphyrin molecules.These molecules, which play an important role in biological processes such as photosynthesis and oxygen transport, are also",{"id":85,"funder":7,"programme":8,"title":86,"piName":10,"institution":87,"country":12,"year":13,"amount":88,"abstract":89},"cordis-marie-skłodowska-curie-actions-award-39494","QCD Spectral Function from both Euclidean and Light Cone Transverse Lattice QCD","UNIVERSITY OF WALES SWANSEA","€160,180","Data on Quark-Gluon plasma (QGP) are expected to come from the upcoming experiments at ALICE and RHIC and expected to yield comprehensive understanding of this new phase of QCD. The strongly interacting quark-gluon plasma (sQGP) is now believed to be the appropriate theory to understand the dynamics in this phase and hence nonperturbative studies are essential.  The main objective of this project is to theoretically analyze the characteristics of the sQGP, focusing in particular on questions rel",{"id":91,"funder":7,"programme":8,"title":92,"piName":10,"institution":93,"country":94,"year":13,"amount":95,"abstract":96},"cordis-marie-skłodowska-curie-actions-award-45821","Modern methods in mathematics","GESELLSCHAFT MATHEMATISCHES FORSCHUNGSINSTITUT OBERWOLFACH GMBH","DE","€683,344","Proposal for support of 36 conferences with support for 576 eligible event participants in 2007 at the Mathematisches Forschungsinstitut Oberwolfach (MFO), on Modern Methods in Mathematics within the programme Marie Curie Conferences and Training Courses\u002FSeries of Events. The MFO is one of the leading mathematical research centres worldwide, which organises weekly high-level international conferences in all fields of mathematics and its applications.The aim of these conferences is to present the",{"id":98,"funder":7,"programme":8,"title":99,"piName":10,"institution":100,"country":101,"year":13,"amount":102,"abstract":103},"cordis-marie-skłodowska-curie-actions-award-41348","European citizenship education: towards which patriotism? a normative analysis of civic education on the eu scale","UNIVERSITE LIBRE DE BRUXELLES","BE","€86,469","With the advent of the EU constitution, especially after the French and Dutch No to the draft Constitution, the question of how to create a sense of belonging and solidarity among European citizens has become of a great importance. In this respect, civic education is viewed as a way to put the EU citizenship into practice. More precisely, it is widely considered as a means to foster the cohesion of the European political community as well as the common allegiance to it. But, given the fact of pl",{"id":105,"funder":7,"programme":8,"title":106,"piName":10,"institution":107,"country":12,"year":13,"amount":108,"abstract":109},"cordis-marie-skłodowska-curie-actions-award-38960","Arithmetic of K3 Surfaces","UNIVERSITY OF WARWICK","€125,539","Luijk's research is on explicit methods in higher-dimensional arithmetic algebraic geometry, motivated by Diophantine problems. In particular, he works on K3 surfaces, which are of interest to algebraic geometers, number theorists and theoretical physicist s. In his thesis, Luijk solved two explicit open Diophantine problems. He also developed a method to bound the rank of the Neron-Severi group of a K3 surfaces. He has constructed K3 surfaces over the rationales with infinitely many rational po",{"id":111,"funder":7,"programme":8,"title":112,"piName":10,"institution":40,"country":12,"year":13,"amount":113,"abstract":114},"cordis-marie-skłodowska-curie-actions-award-41788","Constructing the auditory scene: representations and dynamics","€171,634","Sound sources within the environment produce an aggregate wave-form that enters each ear. To make sense of the world, a listener must separate this input into source-related components. This research proposal concerns the processes by which sensory information is converted into a perceptual representation relevant for behaviour. Studies that target different stages of perceptual processing often employ different tools, different preparations (e.g. humans vs. animal models), as well as different ",{"id":116,"funder":7,"programme":8,"title":117,"piName":10,"institution":118,"country":119,"year":13,"amount":120,"abstract":121},"cordis-marie-skłodowska-curie-actions-award-980026","Non-linear Transport and Tunnelling in low dimensional Lattices","DEPARTMENT OF PHYSICS, TBILISI STATE UNIVERSITY","GE","€9,979","A one-year collaboration of the proposed researcher with the Italian Host is planned in order to develop general theoretical approaches to boundary driven non-linear transport phenomena and tunnelling processes and to seek for applications in various realistic non-linear physical systems. In particular, this proposal intends to generalize the transmission hysteresis effect, that we discovered in Fermi-Pasta-Ulam lattices, by predicting the conditions for the realization of similar effects in opt",{"id":123,"funder":7,"programme":8,"title":124,"piName":10,"institution":125,"country":20,"year":13,"amount":126,"abstract":127},"cordis-marie-skłodowska-curie-actions-award-21998","Synaptic plasticity and long-term depression in the nucleus accumbens after in vivo exposure to addictive drugs","EQUIPE AVENIR INSERM INSTITUT MAGENDIE","€159,353","Consumption of addictive drugs causes changes in the brain areas involved in rewarding behaviours that are essential to an animal's survival and adaptation. One of these areas is the nucleus accumbens. Normally occurring synaptic plasticity in the nucleus accumbens; such as a long-term decrease in synaptic strength mediated by cannabinoids (long-term depression); can change after brief or chronic exposure to addictive drugs.My project will examine commonalities between changes in long-term depre",{"id":129,"funder":7,"programme":8,"title":130,"piName":10,"institution":131,"country":94,"year":13,"amount":132,"abstract":133},"cordis-marie-skłodowska-curie-actions-award-25639","Dynamics and regulation of cell adhesion in the control of morphogenesis","EUROPEAN MOLECULAR BIOLOGY LABORATORY","€148,021","Cells usually organize themselves into groups before migrating from one place to another in vivo. Most of the time, such groups migrate as three-dimensional entities and contacts between cells are highly dynamic. Unfortunately, such complex behaviours are rarely observed in vitro, where cells migrate as individuals. Therefore, although this collective migration is a general feature during both tissue morphogenesis and tumour metastasis, little is known about the basic cellular mechanisms underly",{"id":135,"funder":7,"programme":8,"title":136,"piName":10,"institution":137,"country":138,"year":13,"amount":139,"abstract":140},"cordis-marie-skłodowska-curie-actions-award-46134","Developing a European policy model for cardiovascular disease","THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (HEREINAFTER CALLED TCD)","IE","€236,215","Cardiovascular disease (CVD) generates a massive burden of disease and death in Europe. The majority of CVD cases are preventable. Planners, policy makers and professionals are increasingly using epidemiological\u002Fpolicy models to explain past trends, and address the future CVD epidemic. A variety of CVD policy models exist, each with their own strengths and weaknesses. These include IMPACT, RIVM CDM, SPPM, BET-CI, MSLT and Prevent. However, most modelling groups are working independently.There is",{"id":142,"funder":7,"programme":8,"title":143,"piName":10,"institution":144,"country":94,"year":13,"amount":145,"abstract":146},"cordis-marie-skłodowska-curie-actions-award-41335","Pseudo-Riemannian Geometry: holonomy groups, homogeneous spaces, and foliations","HUMBOLDT-UNIVERSITäT ZU BERLIN","€141,784","This project focuses on global pseudo-Riemannian geometry, i.e. geometry of manifolds with a non-degenerate, but indefinite, metric. The aim is to investigate, and if possible classify, global special pseudo-Riemannian geometries, in particular: (1) pseudo-Riemannian manifolds with a special holonomy group, (2) homogeneous (in particular symmetric) pseudo-Riemannian spaces, (3) foliated manifolds with a homogeneous transverse pseudo-Riemannian geometry, or with totally geodesic leaves. The main ",{"id":148,"funder":7,"programme":8,"title":149,"piName":10,"institution":46,"country":12,"year":13,"amount":150,"abstract":151},"cordis-marie-skłodowska-curie-actions-award-39983","Representation theory of Schur algebras","€152,809","Two of the central problems in the representation theory of reductive algebraic groups are, firstly, to understand simple representations and their characters (in particular, to determine the so-called decomposition numbers), and, secondly, to determine ex tensions between simple representations, thus aiming to describe indecomposable ones.Schur algebras are a class of finite-dimensional algebras whose representation theory encapsulates the representation theory of (infinite) reductive algebraic",{"id":153,"funder":7,"programme":8,"title":154,"piName":10,"institution":19,"country":20,"year":13,"amount":155,"abstract":156},"cordis-marie-skłodowska-curie-actions-award-41443","Deformed geometry and phenomenology","€142,866","Modern physical approach to non(anti)commutative geometry lies on the concept of effective field theory. In the main framework of String Theory, quantum field theories defined on such deformed structures appear in the low energy limits of particular configurations of D-branes, preserving different amount of supersymmetry, according with the deformation involved.Therefore besides the mathematical aspects of these space-time deformations, a phenomenological perspective is needed and powerful algeb",{"id":158,"funder":7,"programme":8,"title":159,"piName":10,"institution":160,"country":12,"year":13,"amount":150,"abstract":161},"cordis-marie-skłodowska-curie-actions-award-41519","Biology and the justification of ethics","THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","Evolutionary ethics has long been concerned with explanations of ethics and ethical systems. However, it seems that, from that standpoint, no satisfactory account of the justification of ethics has yet been given. This raises the questions whether such explanations really engage with our ethical systems as such, i.e. as systems of norms.On the other hand, classical justifications of ethical behaviour and ethical systems based on the normativity of human agency normally fail to recognize any role",{"id":163,"funder":7,"programme":8,"title":164,"piName":10,"institution":165,"country":94,"year":13,"amount":166,"abstract":167},"cordis-marie-skłodowska-curie-actions-award-39562","Stable equivalences of Morita type","UNIVERSITAET ZU KOELN","€151,393","Representation theory of groups, rings and algebras describes and compares categories of modules or representations, or related categories such as derived or stable categories. Equivalences between such categories need to be studied in order to reduce new examples to known ones and to exhibit new connections between seemingly different situations. While the classical notion of Morita equivalence is well known, much less is known about equivalences of derived or stable categories, which are the s",{"id":169,"funder":7,"programme":8,"title":170,"piName":10,"institution":70,"country":20,"year":13,"amount":171,"abstract":172},"cordis-marie-skłodowska-curie-actions-award-042111","Galaxy Formation and Evolution and the role of AGN","€146,268","We propose a 2 years research project to be carried out at the Institut d' Astrophysique de Paris (IAP) under the supervision of Prof. A. Omont. The ultimate main goal of the project is to investigate the link between galaxy evolution and AGN activity. Recent observations and models suggest that AGN activity occurs during a specific phase of the lifetime of a galaxy. Super-massive black-hole (SMBH) are ubiquitous in the centre of all galaxies, but they are active only for a relatively small frac",{"id":174,"funder":7,"programme":8,"title":175,"piName":10,"institution":176,"country":177,"year":13,"amount":178,"abstract":179},"cordis-marie-skłodowska-curie-actions-award-46557","Geometry of groups and manifolds","UNIVERSITA' DI PISA","IT","€40,000","The project falls within the framework of research in geometric group theory, a new research field that combines the techniques and results of classical fields as geometry and group theory. This bridge between these fields gave rise to a quick and fruitful development of group theory, providing techniques to solve classical problems and opening new borders and horizons of research.In particular, many computational problems that seemed quite hard using traditional viewpoints, have been solved via",{"id":181,"funder":7,"programme":8,"title":182,"piName":10,"institution":183,"country":184,"year":13,"amount":185,"abstract":186},"cordis-marie-skłodowska-curie-actions-award-41108","The photometric evolution and age determinations of unresolved star clusters: the effect of selective mass loss from dissolving clusters","UTRECHT UNIVERSITY","NL","€141,337","Star clusters, even unresolved, are ideal chronometers for the study of the star formation history of normal and starburst galaxies in the local Universe. Star cluster ages and masses can be derived from their spectra\u002Fphotometry by comparing these with cluster evolution models. However, presently available spectrophotometric cluster evolution models do not take into account cluster disruption, mass segregation and the preferential ejection of low-mass stars from the clusters and the resulting ch",{"id":188,"funder":7,"programme":8,"title":189,"piName":10,"institution":190,"country":191,"year":13,"amount":192,"abstract":193},"cordis-marie-skłodowska-curie-actions-award-45794","Evaluation of sustainability: European conferences and training courses EASY-ECO 2008-2010","VIENNA UNIVERSITY OF ECONOMICS AND BUSINESS ADMINISTRATION","AT","€509,786","[EASY-ECO 2008-2010] is a training and conference programme on evaluations in the specific context of sustainable development. Sustainability evaluations are important for Europe because they support decision-making processes by highlighting strengths and weaknesses of particular policies, programmes and projects, they make policies more transparent and accountable and they support organisational learning. By building on the vast experience of the coordinator of the preceding EASY-ECO projects (",{"id":195,"funder":7,"programme":8,"title":196,"piName":10,"institution":197,"country":34,"year":13,"amount":198,"abstract":199},"cordis-marie-skłodowska-curie-actions-award-25234","CCL18 - a susceptibility gene for atopic eczema regulated by host-microbe interactions?","KAROLINSKA INSTITUTET","€166,488","Atopic disorders are a group of increasingly common multifactorial chronic diseases, which cause inflammatory and degenerative changes in the skin and mucosal surfaces. Among those diseases, atopic eczema represents the most prevalent condition affecting u p to 22% of the paediatric and 1-3% of adult population.The aetiology of atopic eczema involves environmental, genetic and immunological factors. For the prevention and treatment of this disease, advances are needed in the identification of su",{"id":201,"funder":7,"programme":8,"title":202,"piName":10,"institution":203,"country":20,"year":13,"amount":204,"abstract":205},"cordis-marie-skłodowska-curie-actions-award-39461","Moduli spaces and derived categories","UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6","€151,982","We propose a project on the interaction of algebra and geometry, more precisely representation theory of finite dimensional algebras and geometric invariant theory. The main objective is to study moduli spaces and stability conditions for derived categories of finite dimensional algebras.When studying families of objects in derived categories of finite dimensional algebras, there are two approaches, which have proven to be useful. One is the varieties of complexes of projective modules, and the ",{"id":207,"funder":7,"programme":8,"title":208,"piName":10,"institution":209,"country":20,"year":13,"amount":204,"abstract":210},"cordis-marie-skłodowska-curie-actions-award-39021","Complex geometry and Bergman kernel asymptotics for line bundles","UNIVERSITE JOSEPH FOURIER GRENOBLE I","In complex analysis and geometry it is vital to be able to construct many holomorphic sections of a given line bundle over a complex manifold. A line bundle has curvature and it is well known that positive curvature is very favourable. This project will focus on two specific problems that can be summarized as constructing and quot; many and quot; holomorphic sections in two new important situations where previous techniques have not been successful: 1. The curvature of the line bundle is positiv",{"id":212,"funder":7,"programme":8,"title":213,"piName":10,"institution":70,"country":20,"year":13,"amount":178,"abstract":214},"cordis-marie-skłodowska-curie-actions-award-46413","Structure and dynamics of water and ions in smectite","Smectite is a clay mineral that occurs in multiple surface environments, both terrestrial and marine, frequently as one of their main mineral components. It has the unique property of admitting inorganic and organic species as well as water in its interlayer space. Smectite expandability and large surface area make it a main control of the physical and chemical behaviour of the environments where it is found.The present study aims at investigating the structure of smectite from molecular scale t",{"id":216,"funder":7,"programme":8,"title":217,"piName":10,"institution":218,"country":219,"year":13,"amount":28,"abstract":220},"cordis-marie-skłodowska-curie-actions-award-46541","Organizational and communal determinants of technopark performance","SABANCI UNIVERSITY","TR","We propose a project to facilitate the re-integration of Ozgecan Kocak (Derinkok) into the European Research Area as a researcher and teacher. Dr. Kocak is leaving her position as a full time tenure-track faculty member at Columbia University's Graduate School of Business in New York, USA, to join Sabanci University, Istanbul, Turkey.Continuing to do innovative research and keeping in touch with her existing research community while developing new relationships within ERA will be crucial to her ",{"id":222,"funder":7,"programme":8,"title":223,"piName":10,"institution":183,"country":184,"year":13,"amount":224,"abstract":225},"cordis-marie-skłodowska-curie-actions-award-25573","Putting children and adults in Context","€157,759","Recent",{"id":227,"funder":7,"programme":8,"title":228,"piName":10,"institution":229,"country":12,"year":13,"amount":230,"abstract":231},"cordis-marie-skłodowska-curie-actions-award-39673","Reversible Encapsulation","THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE","€159,613","Drug delivery is the major hurdle to success of therapeutic treatments. A large number of potential drugs with high intrinsic activities fall by the wayside during the development because they have unfavourable physicochemical properties.The aim of this proposal is to develop a general strategy for the encapsulation of guest molecules inside container molecules. Current encapsulation strategies make use of- strong covalent bonds to form the molecular container under kinetic control, which result",{"id":233,"funder":7,"programme":8,"title":234,"piName":10,"institution":235,"country":12,"year":13,"amount":236,"abstract":237},"cordis-marie-skłodowska-curie-actions-award-21809","Unravelling the non-perturbative structure of Gauge Theory","IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE","€164,300","This proposal aims to examine non-perturbative properties of gauge theories with little or no super-symmetry using modern string theory tools. In particular, I propose to investigate stringy, non-super-symmetric aspects of gauge\u002Fstring dualities using the newly developed semi-classical approach to these dualities. This method gives a handle on previously inaccessible regions of gauge theories, and will play a key role in unravelling their non-perturbative dynamics. This proposal aims to provide ",{"id":239,"funder":7,"programme":8,"title":240,"piName":10,"institution":241,"country":242,"year":13,"amount":243,"abstract":244},"cordis-marie-skłodowska-curie-actions-award-39087","Neurogenesis in the female Brain: A link to depression in women","NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS","EL","€213,304","Women are twice as likely as men to experience depression in their lives, yet the reasons for this sex difference in mental illness are unknown. Recently it has been proposed that neurogenesis, the production of new neurons in the adult brain is involved i n the expression of major depression, although the studies have only been conducted in males. In this project, the research fellow will examine how stress and learning alter the survival of newly generated neurons in the female versus the male",{"id":246,"funder":7,"programme":8,"title":247,"piName":10,"institution":248,"country":94,"year":13,"amount":249,"abstract":250},"cordis-marie-skłodowska-curie-actions-award-46036","Training in sleep research and sleep medicine","EUROPEAN SLEEP RESEARCH SOCIETY","€658,100","Since problems related to sleep are increasing in modern societies, an increasing number of specialists in both sleep research and sleep medicine are needed. Presently, in Europe there is a large discrepancy between well developed and less developed countries in both sleep research\u002Fmedicine education and practice. In the former countries there is a well established program for training sleep specialists, while in the latter no regular training is available. The European Sleep Research Society (E",{"id":252,"funder":7,"programme":8,"title":253,"piName":10,"institution":254,"country":255,"year":13,"amount":256,"abstract":257},"cordis-marie-skłodowska-curie-actions-award-41326","New methods of assessing and shaping proprioceptive sensibility and movements aesthetics of the blind","OLOMOUC PALACKY UNIVERSITY","CZ","€190,383","The superior aim of the research project is the creation of a new model of motor programme of rehabilitative character for blind children at school age. The programme will be focused on stimulation of development of aesthetic movement of a child. It will complement or be an alternative method of teaching movement for the current programmes. With the use of an appropriately prepared set of exercises it will be possible to more effectively stimulate the development of movement aesthetics in blind ",{"id":259,"funder":7,"programme":8,"title":260,"piName":10,"institution":261,"country":94,"year":13,"amount":178,"abstract":262},"cordis-marie-skłodowska-curie-actions-award-46578","Analysis of the mechanisms that direct gamma-delta T cell homing and function.","MEDIZINISCHE HOCHSCHULE HANNOVER HANNOVER MEDICAL SCHOOL","The genes coding for the alpha, beta, gamma and delta T cell receptor (TCR) chains were cloned over 20 years ago. However, still relatively little is known about T cells that utilize the gamma-delta TCR. Particularly the biological functions of gamma-delta T cells and the mechanisms that govern their homing to specific epithelial tissues remain enigmatic.In the blood and in secondary lymphoid organs, only 1% to 3 % of the T cells are gamma-delta T cells. In contrast, gamma-delta T cells are disp",{"id":264,"funder":7,"programme":8,"title":265,"piName":10,"institution":266,"country":94,"year":13,"amount":267,"abstract":268},"cordis-marie-skłodowska-curie-actions-award-39418","Water Economy of beech in temperate mixed stands: Fading away or going on under stress?","ALBERT-LUDWIGS UNIVERSITÄT FREIBURG","€157,063","Due to recent forest management, most of the natural occupation areas of beech (Fagus sylvatica L.) are now dominated by planted conifers. One of the aims of current forest policy is to revert this process, favouring the natural regeneration of beech and t he growth and quality improvement of adult trees (e.g. directive 92\u002F43\u002FCEE). However, current climatic models predict an overall raise in temperature throughout Europe (up to 1ºC by 2040), together with an increase in summer drought. Although ",{"id":270,"funder":7,"programme":8,"title":271,"piName":10,"institution":272,"country":59,"year":13,"amount":273,"abstract":274},"cordis-marie-skłodowska-curie-actions-award-41363","Gamma-Ray Burst afterglows: illuminating the early Universe","UNIVERSITY OF COPENHAGEN","€176,732","Gamma-Ray Bursts (GRB) are brief and extremely bright flashes, caused by the death of a very massive star. The collision of the explosion with the surrounding interstellar medium (ISM) causes an afterglow at all wavelengths (radio to X-rays).In the optical, spectroscopy of the afterglow allows to infer various properties of the ISM of the galaxy hosting the GRB: the metallicity, the neutral hydrogen gas column density, the dust and molecular hydrogen content, the level of ambient radiation and\u002Fo",{"id":276,"funder":7,"programme":8,"title":277,"piName":10,"institution":278,"country":53,"year":13,"amount":28,"abstract":279},"cordis-marie-skłodowska-curie-actions-award-46470","Obsessive compulsive disorder: a unitary syndrome, or an ambiguous label for separate psychiatric conditions?","THE HEBREW UNIVERSITY OF JERUSALEM","It has long been recognized that obsessive compulsive disorder (OCD), a complex, treatment-resistant disorder, is a heterogeneous syndrome that has several subtypes (e.g., cleaning, checking). Recently, there has been a growing interest in a more discrete nosological approach, which suggests that these subtypes should be considered as distinct psychiatric conditions with specific characteristics and preferred treatments. However, OCD is still treated it as one condition with several different 'm",{"id":281,"funder":7,"programme":8,"title":282,"piName":10,"institution":283,"country":12,"year":13,"amount":284,"abstract":285},"cordis-marie-skłodowska-curie-actions-award-39402","Glazing Behaviour In a Fire Environment","KINGSTON UNIVERSITY","€121,431","The breakage of glass pane during a fire could influence the fire behaviour due to the change from impermeable barriers to large ventilation sources, resulting in the occurrence of the dangerous backdraft phenomena or post flashover flames emerging outside of the openings leading to rapid fire spread to other floors and in the most severe cases even to adjacent buildings.   The project will address the thermally induced stress response of glass to the heat fluxes from fire. Two separable physica",{"id":287,"funder":7,"programme":8,"title":288,"piName":10,"institution":289,"country":290,"year":13,"amount":291,"abstract":292},"cordis-marie-skłodowska-curie-actions-award-42114","Trap assisted spectroscopy and mass measurements at ISOLTRAP","EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH","CH","€183,454","The present structure of the Universe and the paths of element formation are to a large extent determined by ground and isomeric-state properties of nuclei. Ion traps are versatile instruments, successfully applied at radioactive-beam facilities, which con tribute to our understanding of these nuclear properties, e.g. by measuring nuclear masses and charge radii, studying electron-neutrino correlations in beta-decay, or testing the unitarity of the CKM quark-mixing matrix. One prominent example ",{"id":294,"funder":7,"programme":8,"title":295,"piName":10,"institution":296,"country":101,"year":13,"amount":297,"abstract":298},"cordis-marie-skłodowska-curie-actions-award-41333","Generation and characterization of an in vivo model for LRRK2 mutations in Parkinsons Disease","FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW","€200,721","Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases, caused by degeneration of dopaminergic neurons in the substantia nigra. While the cause of the more frequent sporadic forms of PD remains unknown, the recent discovery of mutations in genes causing rare familial forms of PD provide a basis for better understanding of the molecular pathogenesis of the disease. One of these genes, LRRK2, encodes a protein with multiple predicted functional domains. Point mutations le",{"id":300,"funder":7,"programme":8,"title":301,"piName":10,"institution":302,"country":184,"year":13,"amount":185,"abstract":303},"cordis-marie-skłodowska-curie-actions-award-41765","Conformal field theories with Lie superalgebra symmetry and string backgrounds with fluxes","UNIVERSITEIT VAN AMSTERDAM","My project aims at improving the understanding of two crucial issues in string theory, the quantization of strings in flux backgrounds and, closely connected, the AdS\u002FCFT correspondence. In both cases I will address the problem in terms of two-dimensional conformal quantum field theories, (CFTs) which are the basic building blocks of string theory.In this project I will specifically study CFTs based on Lie supergroups, which are extensions of ordinary groups of symmetries involving fermionic deg",{"id":305,"funder":7,"programme":8,"title":306,"piName":10,"institution":46,"country":12,"year":13,"amount":307,"abstract":308},"cordis-marie-skłodowska-curie-actions-award-42103","Structural studies on hepatitis C virus envelope glycoprotein E2","€168,798","Hepatitis C virus (HCV) is an important human pathogen that causes chronic liver diseases in millions of infected people worldwide. HCV is an enveloped single-stranded RNA virus that infects predominantly hepatic cells. The process of viral entry into the host cells is an obvious target for virus inhibition, however the exact mechanism of this event is not known. It is established that the two HCV envelope glycoproteins E1 and E2 are involved. The ectodomain of E2 interacts with high affinity wi",{"id":310,"funder":7,"programme":8,"title":311,"piName":10,"institution":312,"country":12,"year":13,"amount":14,"abstract":313},"cordis-marie-skłodowska-curie-actions-award-39139","Dynamics of the Bacillus subtilis divisome","UNIVERSITY OF NEWCASTLE UPON TYNE","Cell division is essential for the survival and reproduction of a bacterium. During vegetative growth in rod-shaped bacteria, such as Escherichia coli or Bacillus subtilis, cell division takes place at the precise cell centre by the recruitment of the so-called divisome that consists of at least seven conserved essential proteins. Current models of the assembly and dynamics of the divisome are solely based on genetically deduced dependence relationships. Furthermore, there is no information on t",{"id":315,"funder":7,"programme":8,"title":316,"piName":10,"institution":131,"country":94,"year":13,"amount":317,"abstract":318},"cordis-marie-skłodowska-curie-actions-award-042088","Cryo- Electron Microscopy of vitreous sections of biological cells and tissues","€159,331","During my postdoctoral research, I would like to investigate the macromolecular organization of synapses and desmosomes, in brain and skin tissue respectively, by combining cryo-sectioning (CS) and cryo-electron tomography (CET). This novel combination of CS with CET is currently the only approach which should allow the three-dimensional (3D) visualization of the organization of untreated (i.e. unfixed, unstained) tissue at macromolecular resolution.The 3D molecular architecture of the synaptic ",{"id":320,"funder":7,"programme":8,"title":321,"piName":10,"institution":322,"country":12,"year":13,"amount":88,"abstract":323},"cordis-marie-skłodowska-curie-actions-award-40391","Role of PGC 1ß co-activator in the brain: energy homeostasis, obesity, ageing and neuronal death","THE UNIVERSITY OF CAMBRIDGE","Food intake and energy expenditure are the main components of energy balance and both are regulated by the central nervous system (CNS). Failure of these homeostatic mechanisms results in deregulation of lipid and glucose metabolism leading to insulin resistance and obesity.Defects in energy homeostasis may impact neuronal survival and accelerate the neurodegenerative process associated with ageing. The CNS receives peripheral nutritional signals that acting on specific hypothalamic nuclei and c",{"id":325,"funder":7,"programme":8,"title":326,"piName":10,"institution":327,"country":138,"year":13,"amount":328,"abstract":329},"cordis-marie-skłodowska-curie-actions-award-38754","Symmetry and shape","UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK","€131,692","The increasingly demanding challenges in our society and environment constantly require the development of new innovative ideas. These ideas often originate from mathematical models of phenomena in natural and life sciences, in medicine and business, in technology and engineering, in manufacturing and design, and in other areas. Many of these models lead to geometric structures describing the phenomena precisely or, in most cases, approximately. Innovation and scientific development depends upon",{"id":331,"funder":7,"programme":8,"title":332,"piName":10,"institution":333,"country":94,"year":13,"amount":334,"abstract":335},"cordis-marie-skłodowska-curie-actions-award-42695","Non-linear Sigma Models in String Theory","STIFTUNG DEUTSCHES ELEKTRONEN SYNCHROTRON","€983,536","Understanding gauge theories is absolutely basic for fundamental physics. However, the strong coupling behaviour of gauge theories is not well understood at present. The AdS-CFT-correspondence has opened new perspectives for the study of gauge theories. It could allow us in particular to study strongly coupled gauge theories with the help of weakly coupled string theory. However, the relevant string theories are string theories on Anti-de Sitter (AdS) spaces, which are not yet well understood th",{"id":337,"funder":7,"programme":8,"title":338,"piName":10,"institution":339,"country":34,"year":13,"amount":340,"abstract":341},"cordis-marie-skłodowska-curie-actions-award-39909","Membrane proteins in nanometric holes: Real-time monitoring of membrane-mediated reactions by localized surface plasmons","CHALMERS TEKNISKA HOEGSKOLA AB","€156,315","Cells are highly compartmented by biological membranes. Besides their function as boundaries between organelles, membranes are complex reaction centers with specialized biochemical functions. Although lipid bilayers provide the basic structure of membranes, membrane proteins are responsible for their functional properties. In fact, 25 % of all proteins encoded in the human genome are membrane bound and about 50 % of all current molecular drug targets are located on membranes. Despite their outst",{"id":343,"funder":7,"programme":8,"title":344,"piName":10,"institution":46,"country":12,"year":13,"amount":345,"abstract":346},"cordis-marie-skłodowska-curie-actions-award-39287","Language birth and language death in a multicultural Context: The Case of Coptic","€220,820","The ways in which languages interact, live and die, in political contexts that impose one or two dominant languages are today a central question for Europe. This project aims to address it through the study of a medieval Middle Eastern society with similar characteristics (multicultural, multilingual, religiously diverse, loosely unified politically, with strong local historical traditions), but remote enough as to enable a dispassionate analysis.The project will focus on the social history of t",{"id":348,"funder":7,"programme":8,"title":349,"piName":10,"institution":350,"country":290,"year":13,"amount":351,"abstract":352},"cordis-marie-skłodowska-curie-actions-award-39605","Hydrothermal evolution of cassiterite-sulfide veins - insights from laser-ablation microanalysis of melt and fluid inclusions in the host-rocks and ores of the San Rafael deposit, SE Peru","EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH","€187,424","Granite-related hydrothermal veins typically have high ore grades and tonnages and thus are an excellent target in the search for such commodities as tin, tungsten, silver, copper and many other metals.Although the geology of these deposits is well described, a considerable debate persists about key issues related to their genesis, such as the timing of fluid separation from crystallizing magmas, the controls on ore-metal ratios, and the mechanism of ore deposition.This study proposes to improve",{"id":354,"funder":7,"programme":8,"title":355,"piName":10,"institution":356,"country":101,"year":13,"amount":357,"abstract":358},"cordis-marie-skłodowska-curie-actions-award-42133","Cheaper, faster, less power-hungry embedded systems, by exploiting the potentials of thread- and data-level parallelism hybridisation","INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM VZW","€137,783","The European Framework Programmes have strong emphasis on complex real-time embedded systems. These systems include increasing portions of software applications, and they are subject to constraints on performance, energy consumption and unit cost. These applications are often expressed as multiple concurrent threads, and this shows a high potential of exploitations. In fact, their thread- and data-level parallelism can be mapped as a hybrid combination onto state-of-the-art multi -processor arch",{"id":360,"funder":7,"programme":8,"title":361,"piName":10,"institution":362,"country":59,"year":13,"amount":363,"abstract":364},"cordis-marie-skłodowska-curie-actions-award-38911","Reproductive Isolation and Mating Ecology in Planktonic Copepods","DANMARKS TEKNISKE UNIVERSITET","€24,948","Little is currently known about the mechanisms by which new species arise in marine pelagic environments. One important aspect of the process of speciation is the erection of reproductive isolating barriers between diverging populations. Here I propose a research program to investigate the character and evolution of barriers to heterospecific mating in planktonic marine copepods.   Specifically, I will address the following three objectives,  1) to identify which chemical, hydromechanical, behav",{"id":366,"funder":7,"programme":8,"title":367,"piName":10,"institution":368,"country":290,"year":13,"amount":369,"abstract":370},"cordis-marie-skłodowska-curie-actions-award-41654","Macromolecular crowding in membranes","ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE","€184,021","The aim of the project is to understand, quantify and model the influence of protein crowding in membranes on molecular mobility and interactions of membrane proteins and ultimately on cellular processes in particular signalling. In cellular membranes proteins occupy almost half of the available surface.Obviously, this high total concentration of macromolecules within the membrane will influence processes in the membrane, even while the concentration of proteins involved in a particular process ",{"id":372,"funder":7,"programme":8,"title":373,"piName":10,"institution":374,"country":219,"year":13,"amount":28,"abstract":375},"cordis-marie-skłodowska-curie-actions-award-46476","Utility of tumor antigens as therapeutic and diagnostic tools","BILKENT UNIVERSITESI","The serological profiling of anti-tumour associated antigen responses through large- scale efforts has identified over 2000 antigens. Our preliminary results show a correlation between antibody responses against a number of these with parameters indicative of indolent disease and with longer overall survival in lung cancer patients. The first aim of this project is to extend and establish these observations. Since these are antigens primarily expressed by tissues of neuroectodermal origin, we wa",{"id":377,"funder":7,"programme":8,"title":378,"piName":10,"institution":379,"country":20,"year":13,"amount":380,"abstract":381},"cordis-marie-skłodowska-curie-actions-award-21433","Unravelling pathogenicity of Xanthomonas albilineans, the pathogen causing leaf scald disease of sugarcane","CENTRE DE COOPÉRATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LE DÉVELOPPEMENT","€359,573","Xanthomonas albilineans is an economically serious pathogen and a model system in the world of plant pathology. Other than the genes coding for the biosynthesis of the albicidin toxin, the genes involved in pathogenicity of X. albilineans are unknown. Furthermore, this pathogen is not known to possess avr and hrp genes like other bacteria causing plant diseases.The global aim of this project is to acquire knowledge of the genes involved in pathogenicity of this bacterial species. Thanks to vario",{"id":383,"funder":7,"programme":8,"title":384,"piName":10,"institution":385,"country":386,"year":13,"amount":387,"abstract":388},"cordis-marie-skłodowska-curie-actions-award-980020","Development of mixed starter cultures for the production of high quality cocoa in West Africa","UNIVERSITY OF GHANA","GH","€26,529","Export of cocoa plays a significant economic role in West African countries like Cote d'Ivoire, Ghana and Nigeria, the major cocoa producing region in the World. Fresh cocoa beans have to go through a fermentation and drying step to obtain the desired characteristic 'cocoa flavour'. Traditionally, cocoa beans are fermented through a spontaneous, indigenous fermentation with no control of the microorganisms present. As a consequence, the quality of cocoa varies. These variations negatively influe",{"id":390,"funder":7,"programme":8,"title":391,"piName":10,"institution":392,"country":393,"year":13,"amount":178,"abstract":394},"cordis-marie-skłodowska-curie-actions-award-980027","Interfacial electrochemical bacterial recognition","INSTITUTO DE INVESTIGACIONES EN CIENCIA Y TECNOLOGIA DE MATERIALES","AR","The aim of this project is to investigate fundamental aspects of the physical chemistry of bacterial cell \u002F substrate interactions. Well-defined surfaces of both single crystals and multi-layered gold deposits on quartz elements will be used to resolve the interfacial electrochemistry by capacitance measurements. The use of single crystal electrodes is essential in order to avoid the uncertainties of classical electrode surfaces that have a surface rugosity of the same order of magnitude as the ",{"id":396,"funder":7,"programme":8,"title":397,"piName":10,"institution":107,"country":12,"year":13,"amount":398,"abstract":399},"cordis-marie-skłodowska-curie-actions-award-40126","Combining electrochemical scanned probe microscopy and cavity ring-down Spectroscopy: A new direction for the study of interfacial processes","€169,365","This IIF project aims to bring a top class young female scientist - Meiqin Zhang - from a leading group at Peking (Beijing) University to work on the characterisation and application of a new instrument at Warwick that combines two state of the art techniques: scanning electrochemical microscopy (SECM) and cavity ring-down spectroscopy (CRDS).This instrument has recently been developed in a joint venture between the Warwick Electrochemistry and Laser Spectroscopy groups and we are very excited b",{"id":401,"funder":7,"programme":8,"title":402,"piName":10,"institution":350,"country":290,"year":13,"amount":403,"abstract":404},"cordis-marie-skłodowska-curie-actions-award-42212","Dynamical quantum groups, deformation quantization of Lie bialgebroids and integrable systems in mathematical physics","€166,460","The main goal of this proposal is two-fold: Study the quantization problem for Lie bialgebroids on one hand and pay attention to many examples coming from physics which are globally identified as dynamical quantum groups on the other hand. We take this problem as a pretext to develop a general mathematical theory of dynamical equations like the Yang-Baxter; one that first appeared in the work of Felder on integrable systems and conformal field theory. This will be the occasion to explicit the pr",{"id":406,"funder":7,"programme":8,"title":407,"piName":10,"institution":408,"country":12,"year":13,"amount":307,"abstract":409},"cordis-marie-skłodowska-curie-actions-award-38780","The evolution of cooperative behaviour: Experimental tests of adaptive explanations and development of evolutionary theory","THE UNIVERSITY OF EDINBURGH","The occurrence of altruistic cooperation is one of the greatest challenges for evolutionary biology. The problem is how can an altruistic behaviour, that is costly to perform but benefits other individuals, be maintained by selection? Recently, a great variety of cooperative traits have been discovered in microbes, which offers exciting experimental possibilities.This proposal aims to investigate siderophore production (SP), a cooperative trait and virulence factor of an opportunistic human path",{"id":411,"funder":7,"programme":8,"title":412,"piName":10,"institution":413,"country":12,"year":13,"amount":414,"abstract":415},"cordis-marie-skłodowska-curie-actions-award-42001","Probing star formation throughout the Universe with Gamma-Ray Bursts","THE UNIVERSITY OF HERTFORDSHIRE","€161,427","The history of structure formation from the first stars and galaxies to the present day is becoming amenable to detailed study for the first time. This project is aimed at better understanding the reionisation of the universe and the star formation history over cosmic time. Gamma-ray bursts (GRBs), the brightest explosions in the universe, offer a direct means of answering these questions via observations of their afterglows and host galaxies. The Swift satellite and its ability to rapidly and a",{"id":417,"funder":7,"programme":8,"title":418,"piName":10,"institution":40,"country":12,"year":13,"amount":47,"abstract":419},"cordis-marie-skłodowska-curie-actions-award-40855","Trafficking of DC in Wiskott Aldrich syndrome","The spatial and temporal distribution of dendritic cells (DC) is essential for the initiation of specific immunity and tolerance. Patients with Wiskott Aldrich Syndrome (WAS) show loss of WAS protein (WASp) function, resulting in impaired immune cell migration and abnormal splenic architecture. Ongoing studies of the host laboratory suggest that DC migration to inflamed tissue and to draining lymphoid tissue is compromised and accompanied by exaggerated production of pro-inflammatory cytokines, ",{"id":421,"funder":7,"programme":8,"title":422,"piName":10,"institution":423,"country":12,"year":13,"amount":88,"abstract":424},"cordis-marie-skłodowska-curie-actions-award-39488","Directing traffic - controlling the course of ring forming reactions: Applications in target synthesis","UNIVERSITY OF MANCHESTER","Many of Nature and apos;s most potent molecules have within their structure, a cyclic arrangement of atoms. Similarly, in the chemical industries, cyclic structural motifs are present in many products. In fact, cyclic organic molecules have an important role to play in all areas of life. The development of new ways to construct such molecules in a controlled and selective manner is understandably a key area of chemistry. We will build on recent discoveries from the Manchester group that show a s",{"id":426,"funder":7,"programme":8,"title":427,"piName":10,"institution":229,"country":12,"year":13,"amount":47,"abstract":428},"cordis-marie-skłodowska-curie-actions-award-41915","Characterisation of the structure of the early oligomeric aggregates on the amyloidogenic pathway of lysozyme","Aberrant folding and aggregation of soluble proteins into amyloid-like deposits has been associated to more than 20 known human disorders, including Alzheimer's disease, spongiform encephalopathies and type II diabetes. Recent research has indicated that the early oligomers present prior to amyloid fibril formation represent the most dangerous species to the cell and that their specific conformational properties determine their toxicity. It has been therefore realised that the structural charact",{"id":430,"funder":7,"programme":8,"title":431,"piName":10,"institution":432,"country":53,"year":13,"amount":28,"abstract":433},"cordis-marie-skłodowska-curie-actions-award-46546","The role of MLCK in synaptic plasticity and memory formation","UNIVERSITY OF HAIFA","Our long-term goal is to understand the role of cellular and molecular processes in mediating memory formation. Toward that end, we are employing fear conditioning which is an especially useful behavioural paradigm for studying the molecular basis of long-term memory. The prevailing hypothesis is that learning and memory depend on signalling molecules that affect synaptic efficacy.The specific aim of this proposal is to provide a comprehensive assessment of the role of myosin light chain kinase ",{"id":435,"funder":7,"programme":8,"title":436,"piName":10,"institution":437,"country":242,"year":13,"amount":28,"abstract":438},"cordis-marie-skłodowska-curie-actions-award-46459","Anti-tumour CD8 immunity influenced by epigenetic alterations","UNIVERSITY OF THESSALY","Cancer is a systemic disease characterized by a plethora of epigenetic alterations with extensive disturbances of DNA-methylation that play a crucial and nodal role in carcinogenesis. However, the question that arises is whether similar epigenetic alterations can also take place in genes of immune cells and interfere with the anti-tumour immune response.The hypothesis underlying this proposal postulates that spreading of epigenetic alterations is taking place in cancer affecting the expression o",{"id":440,"funder":7,"programme":8,"title":441,"piName":10,"institution":442,"country":20,"year":13,"amount":443,"abstract":444},"cordis-marie-skłodowska-curie-actions-award-39860","Study of newly-discovered matter in very energetic collisions of hadrons or heavy ions","COMMISSARIAT A L'ENERGIE ATOMIQUE","€240,025","A hadron is a particle whose behaviour is governed by the theory of strong interactions: quantum chromodynamics (QCD). It was recently predicted that any hadron should behave as a new universal form of matter when undergoing a collision at very high energies.Hints of manifestations of this new hadronic matter called the Color Glass Condensate (CGC) may have been already observed at the Relativistic Heavy Ion Collider (RHIC) and at the Hadron Electron Ring Accelerator (HERA).Objectives:- To study",{"id":446,"funder":7,"programme":8,"title":447,"piName":10,"institution":448,"country":94,"year":13,"amount":449,"abstract":450},"cordis-marie-skłodowska-curie-actions-award-39351","Genomic screens to identify and characterize mechanisms of mycobacterial killing by Macrophages","EUROPEAN MOLECULAR BIOLOGY LABORATORY, HEIDELBERG","€158,197","Non-pathogenic mycobacteria are efficiently phagocytosed by macrophages and killed within phagosomes by acid hydrolases, reactive nitrogen intermediates, and likely other still unidentified factors that are part of the macrophage pro-inflammatory response. In contrast, pathogenic mycobacteria such as M. tuberculosis survive and grow within phagosomes by blocking macrophage pro-inflammatory responses, including the NF-kB transcription system, phago-lysosome fusion, acidification and nitric oxide ",{"id":452,"funder":7,"programme":8,"title":453,"piName":10,"institution":454,"country":184,"year":13,"amount":267,"abstract":455},"cordis-marie-skłodowska-curie-actions-award-40797","Migration of HSCs from the AGM region to other haemopoietic organs during mouse ontogeny","DEPARTMENT OF CELLULAR BIOLOGYERASMUS UNIVERSITY","During my PhD I concentrated on the transcriptional regulation of growth control and terminal differentiation in megakaryocytes leading to platelet release. All mature blood cells including platelets have a limited life-span and need to be constantly replaced during life.As haemopoietic stem cells (HSCs) are the foundation for this life-long production, I became interested in the specification of the haemopoietic system from HSCs during ontogeny. In mammals the first adult-type HSCs arise in the",{"id":457,"funder":7,"programme":8,"title":458,"piName":10,"institution":312,"country":12,"year":13,"amount":459,"abstract":460},"cordis-marie-skłodowska-curie-actions-award-24790","Investigating the core function of mitochondrial homologues","€168,799","Mitochondri",{"id":462,"funder":7,"programme":8,"title":463,"piName":10,"institution":464,"country":177,"year":13,"amount":465,"abstract":466},"cordis-marie-skłodowska-curie-actions-award-39574","Role of the MCP-1\u002FCCR2 system in the podocyte alterations of Diabetic Nephropathy: an in vivo and in vitro study","UNIVERSITY OF TURIN, DEPARTMENT OF INTERNAL MEDICINE","€196,105","Diabetic Nephropathy (DN) is the commonest cause of renal replacement therapy in the Western World. Hyperglycaemia and hypertension are the major determinants in the pathogenesis of DN and inflammatory mechanisms are believed to contribute to the glomerular damage. The Applicants hypothesis is that the chemokine Monocyte Chemoattractant Protein-1 (MCP-1), which is over-expressed by podocytes in experimental diabetes, plays a key role in the pathogenesis of the alterations characteristic of DN. T",{"id":468,"funder":7,"programme":8,"title":469,"piName":10,"institution":470,"country":471,"year":13,"amount":472,"abstract":473},"cordis-marie-skłodowska-curie-actions-award-41083","Involvement of invariant chain in antigen processing and presentation in dendritic cells","UNIVERSITETET I BERGEN","NO","€196,655","The processing and presentation of antigenic peptides on MHC class II molecules are an important prerequisite of the immune system to be able to defend against invading pathogens, monitor self-reactivity, and fight tumour cells. These delicate antigen presentation pathways regulating the generation of MHC class II peptides require a multitude of different compartments and proteases within the cell, which need to be clarified. In the proposed project, confocal live cell imaging will be used to in",{"id":475,"funder":7,"programme":8,"title":476,"piName":10,"institution":477,"country":12,"year":13,"amount":478,"abstract":479},"cordis-marie-skłodowska-curie-actions-award-38381","Aspects of string Theory","QUEEN MARY AND WESTFIELD COLLEGE","€262,610","String Theory is the most promising candidate for a theory of quantum gravity that we have. Indeed, it is hoped that it encodes all the physics we see in the experiments, and therefore it is regarded as a theory of everything. As such, it is believed that String Theory should give answers to some of the most fundamental questions, such as the nature of gravity, or the origin of the Universe. It is also important to mention that the next few years are extremely exciting, not only for String Theor",{"id":481,"funder":7,"programme":8,"title":482,"piName":10,"institution":483,"country":20,"year":13,"amount":484,"abstract":485},"cordis-marie-skłodowska-curie-actions-award-41233","Virulence evolution in mixed-species infections","CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE-DELEGATION LANGUEDOC-ROUSSILLON","€158,786","Typically organisms face simultaneous attack from numerous pathogens. Despite this, interactions between different parasite species within the same host have not been investigated extensively. Studies indicate that competition for host resources between parasite species in the same host does occur, but the importance of this competition for disease evolution remains largely unresolved. In particular competition between different parasite species may have important implications for the levels of ",{"id":487,"funder":7,"programme":8,"title":488,"piName":10,"institution":489,"country":490,"year":13,"amount":491,"abstract":492},"cordis-marie-skłodowska-curie-actions-award-39327","Study of NFATc1 activation in heart valve development","FUNDACION CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III","ES","€255,187","Heart valve malformations occur in 2-3% of the population, leading to significant morbidity and mortality. However, very little is known about valve formation at the molecular level. During valve development, NFATc1 proteins are active and located in the nuclei of endocardial cells. In this research project, I propose to study the upstream regulator(s) of endocardial NFATc1 activity required for heart valve elongation and remodelling. My long-term career goal is to elucidate the molecular mechan",{"id":494,"funder":7,"programme":8,"title":495,"piName":10,"institution":496,"country":490,"year":13,"amount":497,"abstract":498},"cordis-marie-skłodowska-curie-actions-award-40141","OBESTATIN AS A REGULATOR OF ENERGY BALANCE: NEUROENDOCRINE TARGETS AND MOLECULAR MECHANISMS","UNIVERSIDADE DE SANTIAGO DE COMPOSTELA","€157,667","Ghrelin is a 28aamino acid peptide derived from a prepropeptide of 117 residues, named pre-proghrelin. Very recently it was identified a new ghrelin-associated peptide encoded by a 23aamino acid peptide, with a flanking conserved glycine residue at the C terminus named obestatin. Obestatin showed a high affinity for GPR39 and needs an amidation to be biologically active.   Regarding its physiological effects, obestatin is able to antagonize ghrelin effects on food intake, body weight and gastric",{"id":500,"funder":7,"programme":8,"title":501,"piName":10,"institution":502,"country":20,"year":13,"amount":126,"abstract":503},"cordis-marie-skłodowska-curie-actions-award-39704","Study of new layered transition metal sulphides synthesised under high pressure","UNIVERSITé PIERRE ET MARIE CURIE-PARIS 6","Layered transition metal sulphides (LTMS) are an ideal playground to explore important issues of condensed matter physics, such as strong electron correlation effects, in less ionic systems than oxides.The reduced ionicity leads to a larger structural flexibility, a better tunability of the valence of the TM ions and therefore to the control of electronic correlations in a wider range of parameters. In this project, we aim at the high-pressure synthesis and study of the electronic properties of ",{"id":505,"funder":7,"programme":8,"title":506,"piName":10,"institution":507,"country":20,"year":13,"amount":508,"abstract":509},"cordis-marie-skłodowska-curie-actions-award-40725","Mechanism of BVDV fusion","INSTITUT PASTEUR","€158,219","Increasing evidence suggested that BVDV glycoprotein E2 belongs to the class II viral fusion proteins like flavivirus E and alphavirus E1 protein. In spite of further similarities in entry pathways of BVDV and flavi- and alphaviruses, recently a fundamental difference in the initiation of fusion process was reported.While flavi- and alphavirus fusion is initiated upon environmental acidification, BVD virions are stabilized by disulfide bridges in the viral glycoproteins. Reduction of these disul",{"id":511,"funder":7,"programme":8,"title":512,"piName":10,"institution":513,"country":12,"year":13,"amount":398,"abstract":514},"cordis-marie-skłodowska-curie-actions-award-39253","Novel Flavour and Fragrance Molecules from Native Chinese Flora","GIVAUDAN UK LTD","This proposal seeks to identify new natural molecules from the Chinese flora that have potential application in the European flavour and fragrance industry. In order to achieve this, the techniques used for extraction, isolation and selection of target compounds must first be substantially improved. Improvements in the isolation, identification and selection of target molecules will be achieved through the novel use of a single machine combining gas chromatography, mass spectrometry and olfactiv",{"id":516,"funder":7,"programme":8,"title":517,"piName":10,"institution":518,"country":290,"year":13,"amount":519,"abstract":520},"cordis-marie-skłodowska-curie-actions-award-40458","Lattice QCD with light dynamical quarks","EUROPEAN ORGANISATION FOR NUCLEAR RESEARCH","€173,831","Quantum chromodynamics (QCD) has been validated through a large amount of experiments. However, since the theory has not been solved analytically, quantitative predictions of its low-energy phenomenology from first principles (a key element in the understanding of both the strong and the weak interactions) can be achieved only through the use of a lattice regularisation.A recent breakthrough (based on the use of domain decomposition methods) in the field of simulation algorithms has opened the w",{"id":522,"funder":7,"programme":8,"title":523,"piName":10,"institution":524,"country":12,"year":13,"amount":14,"abstract":525},"cordis-marie-skłodowska-curie-actions-award-39186","Molecular genetics of host specialisation in pea aphids","THE UNIVERSITY OF SHEFFIELD","The study of host-associated forms has taught us a great deal about the ecological and genetic processes involved in speciation. In the complex of host races collectively named Acyrthosiphon pisum, or the pea aphid, the increasing availability of genomic data offers us the opportunity to search directly for genetic differences contributing to the adaptation to novel host plants. This project aims to elucidate the genetic basis of host acceptance, a major determinant of host plant specialization,",{"id":527,"funder":7,"programme":8,"title":528,"piName":10,"institution":529,"country":20,"year":13,"amount":28,"abstract":530},"cordis-marie-skłodowska-curie-actions-award-46575","Role of Crumbs 3 and its partners in vesicular transport and ciliogenesis","CENTRE NATIONAL POUR LA RECHERCHE SCIENTIFIQUE","One person in 3000 in the world suffers from Retinis Pigmentosa, which leads to degeneration of essential cells of retina: the polarized photosensitive cells or photoreceptors. Several forms of Retinis Pigmentosa can cause partial or total blindness.Their origin is still unknown and there is no efficient therapy to cure or even prevent them. Numerous studies have shown that CRB1, one of the 3 genes encoding for the human family of proteins CRUMBS (Crb1, 2 and 3), is mutated in 60% of patients su",{"id":532,"funder":7,"programme":8,"title":533,"piName":10,"institution":534,"country":177,"year":13,"amount":535,"abstract":536},"cordis-marie-skłodowska-curie-actions-award-39529","Talos Dome ice core Climate-related variability of Iron, CO2 and Carbon isotopes in the Southern Ocean","CONSIGLIO NAZIONALE DELLE RICERCHE","€145,447","Polar ice cores are a sensitive archive of climate change, offering a record of past atmospheric conditions and allowing an accurate assessment of the impact of contemporary climate variations. Climate data for the past 800,000 years has come from deep ice cores drilled in central Antarctica, but shorter records from coastal Antarctica are of considerable interest because of the importance of the Southern Ocean in the global climate system. We propose to analyse samples from an ice core drilled ",{"id":538,"funder":7,"programme":8,"title":539,"piName":10,"institution":442,"country":20,"year":13,"amount":540,"abstract":541},"cordis-marie-skłodowska-curie-actions-award-39968","From neutrino mass phenomenology to the particle physics theory beyond the Standard Model and related signatures in cosmology and colliders","€143,433","The non-vanishing neutrino masses, discovered in oscillation experiments, are the only direct evidence of particle physics beyond the Standard Model. The identification of the origin of neutrino mass shall provide a crucial cornerstone for the construction of the next theoretical framework for particle physics.We propose here to investigate the theoretical implications of neutrino data, more specifically- to evaluate the impact of future measurements for the structure of the neutrino mass matrix",{"id":543,"funder":7,"programme":8,"title":544,"piName":10,"institution":545,"country":490,"year":13,"amount":28,"abstract":546},"cordis-marie-skłodowska-curie-actions-award-46513","Development of nasal vaccines for porcine respiratory pathogens","INSTITUTO NACIONAL DE INVESTIGACIÓN Y TECNOLOGÍA AGRARIA Y ALIMENTARIA","Most vaccines currently available to prevent human or animal diseases are administered by intramuscular or subcutaneous injection. Immunization through parenteral route elicits good systemic responses, although it generally fails to provide protective immunity at the mucosae. However, most pathogens gain access into their hosts through mucosal surfaces, which constitute the first line of defence against invading microorganisms.This project will evaluate the antiviral immune responses at the resp",{"id":548,"funder":7,"programme":8,"title":549,"piName":10,"institution":70,"country":20,"year":13,"amount":550,"abstract":551},"cordis-marie-skłodowska-curie-actions-award-41096","Characterization and dynamics of ribonucleoprotein complexes containing the fragile mental retardation protein involved in the fragile X syndrome","€153,072","Mental retardation (MR) is a major cause of serious handicap in children and young adults and an important medical and social issue affecting 1 to 1.5% of the population. The Fragile X syndrome (FRAXA or FXS) is the most frequent hereditary cause of MR affecting 1\u002F4000 males and 1\u002F7000 females. FMRP, the protein absent in Fragile X patients, is an RNA binding protein component of heterogeneous ribonucleoparticles (mRNP). It plays a role in several steps of mRNA metabolism that range from mRNA tr",{"id":553,"funder":7,"programme":8,"title":554,"piName":10,"institution":555,"country":59,"year":13,"amount":556,"abstract":557},"cordis-marie-skłodowska-curie-actions-award-40995","Function and regulation of the type 2 vasopressin receptor and 'V2R' in body fluid homeostasis","UNIVERSITY OF AARHUS","€189,541","The hypophyseal hormone vasopressin regulates body water balance via the renal vasopressin-type 2 receptor (V2R). Several abnormalities of water balance, in states such as congestive heart failure, kidney, liver and brain disease, are caused by disturbance s in vasopressin action. The role of V2R regulation in these states is poorly understood. V2R is an important drug target with agonists such as dDVAP being used to manage central diabetes insipidus or treat children suffering from nightly urin",{"id":559,"funder":7,"programme":8,"title":560,"piName":10,"institution":350,"country":290,"year":13,"amount":561,"abstract":562},"cordis-marie-skłodowska-curie-actions-award-38908","A combined Cryo Electron Microscopy and mass Spectrometry approach for the structural and functional characterization of the URI-complex","€173,264","Here we propose a novel hybrid strategy for the structure determination of macromolecular complexes using a state of the art mass spectrometry (MS) and cryo-electron microscopy (EM) approach. This strategy allows for the accurate fitting of crystal structures into EM-maps, but also provides structural templates for the identification of macromolecular complexes within cryo-electron tomograms (CET) by pattern recognition. It promises to establish the critical link from structural analysis of isol",{"id":564,"funder":7,"programme":8,"title":565,"piName":10,"institution":566,"country":567,"year":13,"amount":28,"abstract":568},"cordis-marie-skłodowska-curie-actions-award-46461","Milk proteins as carrier proteins in the delivery of bioactive peptides with blood pressure lowering and satiety inducing effects","UNIVERSITY OF OULU","FI","Orally administered bioactive peptides are largely degraded during gastrointestinal digestion. This study examines the possibilities to use milk proteins to deliver bioactive peptides in an active form to target tissues through the intestinal mucosa and thus enhance biological activities of these important compounds. This would have a great impact on preventing the major health risks in the population, such as hypertension, obesity and the metabolic syndrome. Bioactive peptides examined in this ",{"id":570,"funder":7,"programme":8,"title":571,"piName":10,"institution":572,"country":12,"year":13,"amount":47,"abstract":573},"cordis-marie-skłodowska-curie-actions-award-41988","Single molecule mechanical and imaging studies of myosin-V","MEDICAL RESEARCH COUNCIL","The aim of this project is to study the basic mechanisms of myosin-V motility using a combination of single molecule techniques. Many types of cellular motility are based on the cyclical interaction of myosin and actin, coupled to the hydrolysis of ATP. Myosins class V are found in neurons and form dimeric, processive motor molecules moving their cargo along actin filaments for many steps per diffusional encounter. However the basic mechanisms of chemo-mechanical energy transduction and head-hea",{"id":575,"funder":7,"programme":8,"title":576,"piName":10,"institution":40,"country":12,"year":13,"amount":577,"abstract":578},"cordis-marie-skłodowska-curie-actions-award-41532","Does two equal 2? Notational representations in the human brain","€170,500","How human beings process numbers is a fundamental question with extensive impact on almost every aspect of life, both in normal and clinical populations. The aim of this proposal is to find some answers as to whether numbers are represented in an abstract way in the human brain, whether there are multiple representations for different numerical notations, and how learning shapes the way in which we represent numbers.Most theories of numerical cognition support the assumption that the representat",{"id":580,"funder":7,"programme":8,"title":581,"piName":10,"institution":582,"country":290,"year":13,"amount":583,"abstract":584},"cordis-marie-skłodowska-curie-actions-award-39159","Carbon cycling in lakes: Response to water column stratification","EIDGENOSSISCHE ANSTALT FUR WASSERVERSORGUNG,ABWASSERREINIGUNG UND GEWÄSSERSCHUTZ","€239,781","Recent advances in biogeochemistry (biomarker analyses, compound-specific carbon isotope analyses of lipids) and microbiological techniques (FISH, DNA sequencing) have been very successfully employed in deciphering formation and\u002For transformation processes of organic material in the ocean. In contrast to the marine environment, the contribution of terrestrial ecosystems to the global carbon budget and the concentration of greenhouse gases (carbon dioxide, methane) in the atmosphere are only scar",{"id":586,"funder":7,"programme":8,"title":587,"piName":10,"institution":588,"country":12,"year":13,"amount":28,"abstract":589},"cordis-marie-skłodowska-curie-actions-award-46527","Therapeutic targeting of the innate immune system in multiple sclerosis","UNIVERSITY OF NOTTINGHAM","Multiple sclerosis (MS) is neurological disease that is characterized by clinical attacks of paralysis, loss of sensation, loss of vision, and genito-urinary symptoms. MS affects an estimated 500 000 patients in Europe, at a cost to Europe of over 9 billion euro per annum, and is the most frequent cause of neurological disability in young adults. Women are affected approximately twice as often as men.The mechanisms of disease are thought to involve a reaction of the immune system against compone",{"id":591,"funder":7,"programme":8,"title":592,"piName":10,"institution":593,"country":20,"year":13,"amount":594,"abstract":595},"cordis-marie-skłodowska-curie-actions-award-40016","Aging and the asymmetric inheritance of cellular components","INSTITUT NATIONAL DE LA RECHERCHE ET DE LA SANTé MéDICALE","€146,835","The process of aging poses a number of important social as well as scientific challenges. From a biological standpoint, our understanding of the aging process has been advanced by genetic studies in model organisms including yeast, Drosophila and C. elegans. Nevertheless, little is known about the molecular mechanisms involved in cellular aging. Having discovered that the bacterium E. coli ages, we propose to use it as a new model organism to study the causes and consequences of aging at the cel",{"id":597,"funder":7,"programme":8,"title":598,"piName":10,"institution":70,"country":20,"year":13,"amount":126,"abstract":599},"cordis-marie-skłodowska-curie-actions-award-40501","New T cell signaling pathways.","In the immune system, T cells develop their antigen-specificity in the thymus by acquiring a functional T cell receptor (TCR) which triggers intracellular signalling regulating selection, activation and proliferation. The adaptor molecule LAT is functioning as a scaffold protein in a key signalling node of the T cell receptor signalling pathway. Accordingly, mice deficient for LAT or expressing loss-of-function LAT mutants show a dramatic impairment in T cell development. Surprisingly, when a co",{"id":601,"funder":7,"programme":8,"title":602,"piName":10,"institution":107,"country":12,"year":13,"amount":603,"abstract":604},"cordis-marie-skłodowska-curie-actions-award-42481","Harnessing Africa's Brain Drain and Disaspora for its development in the Nepad-United Kingdom and French Partnership","€431,175","The proposed project aims principally to investigate the extent to which Africa's brain drain and Diaspora in the United Kingdom and France play a role and could be converted into brain gain for the development of the continent of origin in the context of New Partnership for Africa's Development (NEPAD) in partnership with the G8 countries. It will provide opportunities for European and African researchers as well as students at the Centre for Research in Ethnic Relations (CRER), University of W",{"id":606,"funder":7,"programme":8,"title":607,"piName":10,"institution":350,"country":290,"year":13,"amount":608,"abstract":609},"cordis-marie-skłodowska-curie-actions-award-41444","Crystallographic studies of the complex between the prokaryotic ribosome and the SecYEG translocon","€177,233","We propose to crystallize the complex of the prokaryotic ribosome or its 50S subunit with the SecYEG translocon. Two SecYEG heterotrimers bind to the ribosome at the end of the nascent polypeptide tunnel to form a transmembrane channel which is part of a translocase complex that allows for secreted and membrane embedded molecules to be transcribed through or into the membrane bilayer respectively.Building on previously established expression and complex formation protocols that allowed the analy",{"id":611,"funder":7,"programme":8,"title":612,"piName":10,"institution":572,"country":12,"year":13,"amount":14,"abstract":613},"cordis-marie-skłodowska-curie-actions-award-39171","Crystallisation and functional analysis of rhodopsin bound to its effector arrestin","Transmission of signals across the plasma membrane is among the most fundamental cellular processes and is medically highly relevant. The largest group of membrane proteins involved in this process are the G protein coupled receptors (GPCRs). Despite their broad physiological relevance, GPCRs share a seven-a-helix architecture and transmit the activation signal by a heterotrimeric guanyl nucleotide-binding protein (G-protein). Also desensitisation of GPCRs occurs via highly conserved mechanisms ",{"id":615,"funder":7,"programme":8,"title":616,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":617},"cordis-marie-skłodowska-curie-actions-award-41465","Natural antimony resistance in leishmania donovani: a fundamental study to guide future epidemiological strategies","Control of leishmaniasis is being challenged by the emergence of natural resistance against the first line treatment - pentavalent antimonials (SbV). Monitoring and prevention of the spreading of drug resistance is now a priority for the control of leishmaniasis.In order to design and develop the required epidemiological tools, it is essential to understand the mechanism of natural SbV resistance and to gain insights into the dynamics of the emergence and\u002For spreading of drug resistance.Within t",{"id":619,"funder":7,"programme":8,"title":620,"piName":10,"institution":229,"country":12,"year":13,"amount":621,"abstract":622},"cordis-marie-skłodowska-curie-actions-award-41693","Analysis of a novel class of integrable partial differential equations","€152,242","The so-called integrable evolution equations possess several remarkable properties. In particular, their initial value problem can be solved using a nonlinear version of the Fourier transform method, called inverse scattering (spectral) method. For evolution equations in one and two spatial dimensions this method involves the Riemann-Hilbert and the d-bar formalisms, respectively.An important advantage of these formulations is that they can be used for the explicit evaluation of the long time be",{"id":624,"funder":7,"programme":8,"title":625,"piName":10,"institution":70,"country":20,"year":13,"amount":626,"abstract":627},"cordis-marie-skłodowska-curie-actions-award-21891","Cosmology, Dark matter and dark Energy","€211,114","Dark matter and dark energy comprise 96% of our Universe and yet we currently know very little about them. The proposed project will address this issue using a new technique, called weak lensing, that is unique as it can detect and measure dark matter and dark energy. We will apply this state-of-the-art tool to the Canada-France-Hawaii Telescope Legacy Survey (CFHTLS), the deepest wide-field astronomical survey ever undertaken. This world-class survey, lead by the EU host, allows for the first i",{"id":629,"funder":7,"programme":8,"title":630,"piName":10,"institution":631,"country":12,"year":13,"amount":632,"abstract":633},"cordis-marie-skłodowska-curie-actions-award-39205","Probing quantum gravitational physics via inflation","UNIVERSITY OF PORTSMOUTH","€159,726","Cosmological inflation is currently considered to be the best paradigm for describing the early stages of the universe. The inflationary epoch magnifies the tiny quantum fluctuations present at the beginning of the epoch into classical perturbations that l eave an imprint as anisotropies in the cosmic microwave background (CMB). It has recently been realised that the predictions of inflation for the spectrum of perturbations may not be robust against trans-Planckian (string) physics. Recently, u",{"id":635,"funder":7,"programme":8,"title":636,"piName":10,"institution":637,"country":94,"year":13,"amount":638,"abstract":639},"cordis-marie-skłodowska-curie-actions-award-42034","The roles of anaerobic and aerobic microbial processes on nitrogen loss from intertidal and estuarine sediments","MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. \u002F MAX-PLANCK INSTITUT FUER MARINE MIKROBIOLOGIE","€112,858","The proposed fellowship will study the roles of anaerobic and aerobic microbial processes on nitrogen loss in estuarine and intertidal sediments. The applicant has 5 years experience in anaerobic microbiology, microbial ecology and environmental biotechnology. He has developed a strong profile, with 19 peer-reviewed papers and over 35 conference proceedings. In order for the applicant to reach his career goals, it is essential that he build on his experience by being trained at a world-leading i",{"id":641,"funder":7,"programme":8,"title":642,"piName":10,"institution":643,"country":644,"year":13,"amount":645,"abstract":646},"cordis-marie-skłodowska-curie-actions-award-40907","Minimal grand unified theory","JOZEF STEFAN INSTITUTE","SI","€112,250","The current paradigm of elementary particle physics, i.e., the so-called Standard Model (SM), has held up superbly under the extensive experimental scrutiny. However, there are reasons to believe that a Grand Unified Theory (GUT) represents more accurate description of electro-weak and strong interactions and elementary particles that participate in them. GUT does not only address some of the conceptual problems of the SM such as anomaly cancellation but it offers possibility to explain various ",{"id":648,"funder":7,"programme":8,"title":649,"piName":10,"institution":131,"country":94,"year":13,"amount":132,"abstract":650},"cordis-marie-skłodowska-curie-actions-award-23608","Phagosome signaling networks from macrophage receptors relevant for mycobacteria","The signalling networks regulating pro-and anti-inflammatory responses are poorly understood. Here, a hypothesis is proposed that these responses have signalling state counterparts at the level of individual membranes. To address this, defined bacterial pr o-and anti-inflammatory ligands will be coated onto beads. During phagocytic uptake of such beads by macrophage plasma membrane, receptors are selected and enriched in phagosomes, which are isolated, offering a dynamic and accessible membrane-",{"id":652,"funder":7,"programme":8,"title":653,"piName":10,"institution":654,"country":138,"year":13,"amount":655,"abstract":656},"cordis-marie-skłodowska-curie-actions-award-39295","Particle acceleration at supernova remnant shocks and the origin of cosmic rays","DUBLIN INSTITUTE FOR ADVANCED STUDIES","€147,642","Cosmic rays are relativistic charged particles (mainly protons and a small fraction of heavier nuclei) hitting Earth from outer space. According to the most popular model for their origin, galactic cosmic rays are accelerated at the outer front of expanding supernova remnants, via the so- called diffusive shock acceleration mechanism. Even though the predictions of this model seem to broadly fit the general picture emerging from observations, we are still waiting for the conclusive proof that su",{"id":658,"funder":7,"programme":8,"title":659,"piName":10,"institution":660,"country":20,"year":13,"amount":661,"abstract":662},"cordis-marie-skłodowska-curie-actions-award-40998","AIP (Aire-Interacting Protein) regulates autoantigen expression","INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE","€204,966","APECED patients suffer from tissue-specific destructive autoimmunity, affecting principally endocrine organs. They indicate a profound defect in immune maturation, especially in the mechanisms leading to tolerance against self-antigens, which occur during negative selection in the thymus. AIRE, the mutated gene in APECED and necessary for maintenance of T-cell tolerance, is responsible for intrathymic expression of peripheral autoantigens. Indeed, AIRE has an activity of transcriptional regulato",{"id":664,"funder":7,"programme":8,"title":665,"piName":10,"institution":368,"country":290,"year":13,"amount":561,"abstract":666},"cordis-marie-skłodowska-curie-actions-award-38746","Labelling of fusion proteins in living mice with synthetic probes","Characterizing the movement, interactions and chemical microenvironment of a protein inside the living cell is the key towards a detailed understanding of its function. While in the past most functional studies of proteins have been performed in vitro or with cell culture experiments, it has become increasingly evident that protein function also needs to be studied on an organismal level. To achieve this objective, there is a generally acknowledged need for new and innovative approaches to study",{"id":668,"funder":7,"programme":8,"title":669,"piName":10,"institution":670,"country":290,"year":13,"amount":671,"abstract":672},"cordis-marie-skłodowska-curie-actions-award-40719","Dissecting the role of Myc and Jun in hematopoietic stem cell self-renewal and cancer formation","ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE","€186,289","All stem cell populations are controlled by a number of intrinsic and external regulatory mechanisms that function in maintaining balance between stem cell self-renewal and commitment to differentiation.Recent evidence also suggests that some cancers are controlled by a small population of tumour cells that exhibit stem cell like qualities (referred to as cancer stem cells) lending to the hypothesis that cancer is a disease of uncontrolled stem cell self-renewal. This proposal aims to elucidate ",{"id":674,"funder":7,"programme":8,"title":675,"piName":10,"institution":676,"country":20,"year":13,"amount":484,"abstract":677},"cordis-marie-skłodowska-curie-actions-award-40262","Grid-like anion complexes","UNIVERSITÉ DE STRASBOURG","The principal aim of the following project is the development and diversification of research competencies of the applicant by means of advanced training through research in a multi-disciplinary field.Thus, the project lies on the borderline of two rapidly developing fields of research: anion recognition and the development of smart functional materials.Grid-like cation complexes, comprising two-dimensional arrays of metal cations connecting a set of organic ligands in a perpendicular arrangemen",{"id":679,"funder":7,"programme":8,"title":680,"piName":10,"institution":681,"country":94,"year":13,"amount":682,"abstract":683},"cordis-marie-skłodowska-curie-actions-award-40904","Visualizing the molecular control of blood - stroma interactions at the single cell level","HELMHOLTZ ZENTRUM MUENCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT","€149,722","The behaviour of hematopoietic cells is influenced by their microenvironment. These niches are composed of variety of cells, including stromal cells. As cells mature, they move from one niche to another within the bone marrow until they are released into the periphery. To further understand these interactions, we will utilize a novel, non-invasive computer-driven microscopy program to visualize the interaction of blood cells with stromal cells at the single cell level.Stromal cells lines have be",{"id":685,"funder":7,"programme":8,"title":686,"piName":10,"institution":229,"country":12,"year":13,"amount":307,"abstract":687},"cordis-marie-skłodowska-curie-actions-award-41586","Stem cell maintenance and reactivation in lateral root initiation","Lateral roots are essential to form a dense root network allowing plants to take up water and minerals effectively from the soil. Laterals are initiated from a specific organogenic cell layer within the differentiated root known as the pericycle.The establishment and maintenance of the pericycle and the subsequent process of lateral root formation is an interesting model to study how stem-cells can be maintained within an otherwise differentiated and endoreduplicated tissue, and how these cells ",{"id":689,"funder":7,"programme":8,"title":690,"piName":10,"institution":432,"country":53,"year":13,"amount":28,"abstract":691},"cordis-marie-skłodowska-curie-actions-award-46524","Diffrential expression of Nostoc PCC7120 psbC gene family","In the last decade, the full genome sequence of a number of cyanobacteria became available. While these efforts have rewarded us with a lot of information, they also open the question: What do all those genes do? This is especially true in the case of multi gene families were multiple genes code for similar but not identical proteins. The genome of one of those, Nostoc PCC 7120 (a.k.a. Anabaena PCC 7120), an filamentous heterocystous cyanobacteria was published in 2001, and found to contain 5 ps",{"id":693,"funder":7,"programme":8,"title":694,"piName":10,"institution":695,"country":490,"year":13,"amount":696,"abstract":697},"cordis-marie-skłodowska-curie-actions-award-41135","Dynamics and complexity in synthetic protein networks","CENTRE DE REGULACIÓ GENÒMICA","€137,581","Synthetic biology aims to assemble unrelated biomolecular parts (genes, proteins) into artificial networks with well-defined dynamic behaviour. This would help elucidating the working principles of complex biological systems but could later also lead to the design of self-organising, interoperating, intelligent bionanotechnological devices. The field has so far mainly focussed on the engineering of transcriptional regulatory networks, which are slow and represent only a fraction of cellular cont",{"id":699,"funder":7,"programme":8,"title":700,"piName":10,"institution":701,"country":101,"year":13,"amount":702,"abstract":703},"cordis-marie-skłodowska-curie-actions-award-39931","Substrate docking and affinity studies of Nicastrin: the binding mechanism","FLANDERS INTERUNIVERSITARY INSTITUTE FOR BIOTECHNOLOGY VZW","€153,319","Beta-Secretase (beta-SEC) is responsible for the intramembrane cleavage of amyloid precursor protein, an event intimately linked to Alzheimer's disease (AD). Beta-SEC is an aspartic protease composed by presenilin, nicastrin (NCT), APH-1, and PEN-2.Beta-SEC appears to have a very broad specificity; however, no quantitative data is available to support this assumption. NCT subunit is a type 1 membrane protein whose ectodomain (NCT ECD) actively participates in the substrate binding. NCT-substrate",{"id":705,"funder":7,"programme":8,"title":706,"piName":10,"institution":76,"country":12,"year":13,"amount":47,"abstract":707},"cordis-marie-skłodowska-curie-actions-award-41211","Wnt signalling and adipose tissue plasticity","Obesity resulting from hypertrophy of adipocytes is more deleterious metabolically than obesity resulting from hyperplasia of new adipocytes. Our aim is to understand the role of Wnt signalling network regulating the balance between hypertrophy and hyperplasic adipose tissue. We hypothesise that over nutrition activates Wnts regulatory mechanisms in adipose tissue to facilitate fat storage in pre-existing adipocytes or inducing differentiation of new adipocytes. Whereas overexpression of Wnts in",{"id":709,"funder":7,"programme":8,"title":710,"piName":10,"institution":711,"country":12,"year":13,"amount":88,"abstract":712},"cordis-marie-skłodowska-curie-actions-award-39691","Evaluation of the genomic effects of four environmentally suspect pharmaceutical compounds on Atlantic salmon","UNIVERSITY OF STIRLING","Pharmaceutical compounds are considered emerging contaminants and possible candidates for the introduction into the Water Framework Directive list of priority substances (2000\u002F60\u002FEC). They are continuously introduced into sewage waters, and as a result, found in surface, ground and drinking waters.Even though they have high transformation and removal rates, they may display chronic exposure characteristics due to their continuous input, as their elimination during wastewater treatment is rather ",{"id":714,"funder":7,"programme":8,"title":715,"piName":10,"institution":716,"country":34,"year":13,"amount":717,"abstract":718},"cordis-marie-skłodowska-curie-actions-award-40534","Silica fluxes and wetlands: assessment of a missing processor in the global Si cycle","LUNDS UNIVERSITET","€165,921","Recent estimates have shown that terrestrial silica cycling is strongly influenced by biota. Terrestrial silica transport is of utmost importance for the coastal zone: the ratio of the nutrients N-P and Si delivered to estuaries, is essential in influencing the occurrence of harmful eutrophication events in the coastal waters.Despite the importance, very little research has focused on quantifying the terrestrial silica cycle. Lack of knowledge has also prevented the correct quantification of an ",{"id":720,"funder":7,"programme":8,"title":721,"piName":10,"institution":722,"country":20,"year":13,"amount":723,"abstract":724},"cordis-marie-skłodowska-curie-actions-award-40688","Virtual screening applied to chemogenomics and protein annotation","UNIVERSITé DE STRASBOURG","€161,529","Since the completion of the human and other organisms' genome sequence, many new druggable targets are expected to be identified by structural genomics with the expectation of developing new therapeutics. One of the bottlenecks of this drug discovery process is the difficulties encountered to understand the function of these new proteins. So far, much emphasis has been given to bioinformatics: the genomes are annotated using sequence analysis or structural modelling. However, these methods are n",{"id":726,"funder":7,"programme":8,"title":727,"piName":10,"institution":728,"country":12,"year":13,"amount":729,"abstract":730},"cordis-marie-skłodowska-curie-actions-award-39185","Information Processing in PULSEd P Environments: Comparison of adaptive phosphorous uptake and the competitive abilities between bloom forming diatoms and the coccolithophore Emiliania huxleyi","THE UNIVERSITY OF ESSEX","€228,758","To date, research on adaptation of photosynthetic microorganisms to external stimuli such as nutrients and light has mainly focussed on full adaptation. The aim of this study is to understand the largely unknown constrains that determine the transition fro m one adaptive state to another. This is not a time invariant phenomenon, but proceeds in a historical context in that every adaptation is determined by previous adaptation of an organism. In this respect the cellular memory will be studied as",{"id":732,"funder":7,"programme":8,"title":733,"piName":10,"institution":734,"country":184,"year":13,"amount":735,"abstract":736},"cordis-marie-skłodowska-curie-actions-award-38905","Local temperature jumps for single Protein Molecules: a route to study dynamics from Microseconds to hours","UNIVERSITEIT LEIDEN","€209,734","We propose to physically trap a single bio-molecule into successive conformational sub-states by rapidly freezing and thawing it with its immediate surroundings. After many successive freeze-thaw cycles, we will reconstruct the dynamics of the same single molecule from the series of frozen snapshots, probed by the fluorescence of optical labels. Fast cooling and heating will be achieved by maintaining the molecule in a focused laser spot within a cold cryostat. We will control the local temperat",{"id":738,"funder":7,"programme":8,"title":739,"piName":10,"institution":160,"country":12,"year":13,"amount":88,"abstract":740},"cordis-marie-skłodowska-curie-actions-award-40511","Functional characterization of TrkB and Ob-R mutations identified in severely obese children","The obesity epidemic is a pressing problem, resulting in diverse metabolic and psychological disorders.Identification of genes whose disruption causes obesity in rodents has led to rapid progress in understanding the signalling pathways responsible for the regulation of body weight in mammals, and an increasing number of severely obese humans have been found to carry mutations in those same genes.The fat-derived hormone leptin and the neurotrophin brain-derived neurotrophic factor (BDNF) are key",{"id":742,"funder":7,"programme":8,"title":743,"piName":10,"institution":46,"country":12,"year":13,"amount":230,"abstract":744},"cordis-marie-skłodowska-curie-actions-award-41811","Interraccions between citotoxic T lymphocytes (CTLs) and Human Immunodeficiency Virus (HIV): viral cost of escape from immune system and implications in vaccine desing","HIV infection is one of the major global health problems of our times and one of the main priority research areas in EU policy for the FP6 program. Although natural immune control of HIV infection can occur, vaccine development has been hindered by difficulties in identifying what immune responses need to be induced. HIV-specific cytotoxic T lymphocyte (CTL) activity plays a central role in control of HIV.Thus, great variability exists between different CTL in their effectiveness. Recent studies",{"id":746,"funder":7,"programme":8,"title":747,"piName":10,"institution":70,"country":20,"year":13,"amount":748,"abstract":749},"cordis-marie-skłodowska-curie-actions-award-40331","Analysis of the Molecular mechanisms controlling the Segmentation Clock during Zebrafish Somitogenesis","€261,050","The periodic formation of somites along the anteroposterior axis of the embryo involves a molecular oscillator, the segmentation clock, as revealed by the expression of cyclic genes in the presomitic medoderm. Notch signalling controls cyclic gene expression, but it is not clear yet whether it operates as a component of the clock, a regulator of it, or both.The project I will develop in the Amacher laboratory at the University of California at Berkeley aims at better understanding the molecular ",{"id":751,"funder":7,"programme":8,"title":752,"piName":10,"institution":753,"country":20,"year":13,"amount":661,"abstract":754},"cordis-marie-skłodowska-curie-actions-award-39762","Gene discovery and disease pathogenesis in the inherited myopathies","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","The proposed project for Dr Aurélie Vandebrouck builds upon discoveries in the Institute for Neuromuscular Research (INMR) and Institut de Myologie (IM) and is designed to take advantage of the existing collaboration between the two centres, the unique resources of DNA and muscle samples collected over the past decade, and the expertise available in the two centres in gene discovery, production of mutant proteins, tissue culture and animal models.Researchers in both Institutions, and others, hav",{"id":756,"funder":7,"programme":8,"title":757,"piName":10,"institution":70,"country":20,"year":13,"amount":758,"abstract":759},"cordis-marie-skłodowska-curie-actions-award-41419","RNA interference and plant cell-to-cell silencing signal","€150,237","RNA silencing refers to the suppression of gene expression through nucleotide sequence-specific interactions that are mediated by 21-25nt-long RNA molecules, referred to as short interfering (si)RNAs. This process serves fundamental biological functions, including antiviral defence, developmental patterning and maintenance of genome integrity.In plants and in some animals, the effects of post-transcriptional RNA silencing can extend beyond its sites of initiation, owing to the movement of signal",{"id":761,"funder":7,"programme":8,"title":762,"piName":10,"institution":763,"country":94,"year":13,"amount":682,"abstract":764},"cordis-marie-skłodowska-curie-actions-award-39849","ClC-5 regulation and endocytosis at the renal proximal tubule or molecular bases of Dents disease","MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN","Mutations in the gene encoding ClC-5, an electrogenic Cl-\u002FH+-exchanger, cause a renal syndrome called Dents disease, which is characterized by genetic heterogeneity lowmolecular weight proteinuria, hypercalciuria, nephrolithiasis and progressive renal failure.By generating a ClC-5 knock out mouse, Thomas J. Jentsch and coworkers demonstrated that the loss of ClC-5 diminishes receptor-mediated and fluid-phase endocytosis. As ClC-5 provides an electrical shunt for the electrogenic pumping by the H",{"id":766,"funder":7,"programme":8,"title":767,"piName":10,"institution":768,"country":20,"year":13,"amount":758,"abstract":769},"cordis-marie-skłodowska-curie-actions-award-41067","Study of the role of notch signaling in controlling cell differentiation and proliferation in the intestinal epithelium","INSTITUT CURIE","The goal of the proposed project is to elucidate the mechanisms of action of Notch signalling, by using the mouse intestine as a model for studying cell lineage specification and stem cell renewal. I propose experiments aimed at identifying the molecular factors that can influence the choice between differentiation and proliferation and at testing the hypothesis that Notch might have a key role in controlling the proliferative potential of gut stem cells. The Notch signalling pathway plays a cen",{"id":771,"funder":7,"programme":8,"title":772,"piName":10,"institution":773,"country":94,"year":13,"amount":774,"abstract":775},"cordis-marie-skłodowska-curie-actions-award-41521","Malaria liver stages: characterization of essential genes for novel intervention strategies","UNIVERSITÄTSKLINIKUM HEIDELBERG","€156,496","During malaria transmission Plasmodium sporozoites actively enter the liver and transform into clinically silent liver stages (LS). Each individual LS undergoes multiple rounds of nuclear divisions and eventually produces thousands of first-generation merozoites that initiate the erythrocytic cycle causing malaria pathology.Liver stages are ideal targets for causal prophylactic drugs and vaccine strategies. Immunization with radiation- or genetically-attenuated parasites confers protective immun",{"id":777,"funder":7,"programme":8,"title":778,"piName":10,"institution":779,"country":20,"year":13,"amount":780,"abstract":781},"cordis-marie-skłodowska-curie-actions-award-40724","Distributed multi-objective optimisation for ad hoc wireless networks","INSTITUT NATIONAL DES SCIENCES APPLIQUÉES DE LYON","€250,844","This proposal tackles the problem of ad hoc wireless networks optimization. Getting the best transmission quality in a wireless ad hoc network with limited resources is one of the main problems research has faced in this area in recent years. Solutions dev eloped are based on medium access and routing protocols.The first difficulty for ad hoc networks is mobility: the changing pattern of users reveals the need for a trade-off between bandwidth maximization and access fairness in the protocols.Th",{"id":783,"funder":7,"programme":8,"title":784,"piName":10,"institution":785,"country":184,"year":13,"amount":786,"abstract":787},"cordis-marie-skłodowska-curie-actions-award-42044","Dendrimers and supramolecular interactions for the design of multivalent objects","TECHNISCHE UNIVERSITEIT EINDHOVEN","€149,275","The project of the post doctoral stay of the candidate in the Laboratory of Macromolecular and Organic Chemistry is depicted in this proposal. The host group, headed by Prof. E. W. Meijer, plays a world leading role in the fields of supramolecular chemistry and dendrimers. Because of their well defined structure and multivalent character, dendrimers are promising nanoscopic structures for biomedical applications, including imaging and drug delivery.The research interest of the candidate as a pre",{"id":789,"funder":7,"programme":8,"title":790,"piName":10,"institution":791,"country":94,"year":13,"amount":792,"abstract":793},"cordis-marie-skłodowska-curie-actions-award-42630","Photochemistry, ultrafast dynamics and diagnostic applications of the III generation photosensitizers","FORSCHUNGSVERBUND BERLIN E.V. \u002F MAX-BORN-INSTITUTE FOR NONLINEAR OPTICS AND SHORT PULSE SPECTROSCOPY","€647,573","The goal of the project is to reach excellence in research on molecular diagnostics by laser methods in Europe and to set-up an unique integrated Network between the single-investigator laser facilities at European Universities and the large-scale national laboratories for research\u002Ftraining\u002Fand teaching on laser technology and applications to contribute to structuring the European research. The present project within the Marie Curie Chair pursues the following specific objectives: 1) to integrat",{"id":795,"funder":7,"programme":8,"title":796,"piName":10,"institution":797,"country":184,"year":13,"amount":798,"abstract":799},"cordis-marie-skłodowska-curie-actions-award-39689","The Human Immune System mouse as a new model to study HIV vaccination","ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM","€148,141","The study of development and function of the immune system in vivo has made intensive use of animal models, but performing such work in human beings is difficult, for experimental, practical and ethical reasons.Confronted to this scientific challenge, several pioneering groups have developed in the late 80s mouse models of human immune system development. The system has now been considerably improved with the Human Immune System (HIS) mouse that exhibits a complete human innate and adaptive immu",{"id":801,"funder":7,"programme":8,"title":802,"piName":10,"institution":803,"country":567,"year":13,"amount":804,"abstract":805},"cordis-marie-skłodowska-curie-actions-award-39348","Mechanisms and determinants of amyloid assembly induced by lipid membranes","HELSINGIN YLIOPISTO","€161,432","Formation of fibrillar protein aggregates (amyloid) is associated with serious diseases of global concern, e.g., Alzheimer's, prion diseases, type II diabetes. Despite the expanding research the mechanisms and determinants of amyloid formation in vivo are poorly understood. In the in vitro studies, rather severe conditions are often necessary to initiate the amyloid assembly (extreme pH, high temperature). In contrast, phospholipid membranes have been recently discovered to facilitate, in an app",{"id":807,"funder":7,"programme":8,"title":808,"piName":10,"institution":809,"country":490,"year":13,"amount":810,"abstract":811},"cordis-marie-skłodowska-curie-actions-award-39053","Assessment and prediction of sediment dynamics within olive orchards","UNIVERSIDAD DE CÓRDOBA","€137,582","The problem of soil erosion is well known and affects large part of the EU. Because of biophysical conditions, the Mediterranean region is among the most susceptible areas. Nevertheless, very little is known on past and present soil erosion rates in olive orchards, a land use type characterized by dramatic erosion rates but at the same time economically and socially very important in this region. Also, traditional erosion models do not perform well in such orchards because of the complex topogra",{"id":813,"funder":7,"programme":8,"title":814,"piName":10,"institution":40,"country":12,"year":13,"amount":815,"abstract":816},"cordis-marie-skłodowska-curie-actions-award-38320","Comprehensive study of the organs and tissues through which insulin-like signalling affects lifespan in Drosophila","€156,211","An evolutionarily conserved neuroendocrine signalling pathway, the insulin\u002Finsulin-like growth factor signalling (IIS) pathway, controls ageing in a number of distantly related organisms. This control appears to result from a complex interaction of different tissues acting as signal emitters and receptors. Using systematic approaches, this project aims to identify the organs and tissues through which IIS affects ageing in Drosophila melanogaster.A combination of biochemical, histological and gen",{"id":818,"funder":7,"programme":8,"title":819,"piName":10,"institution":820,"country":94,"year":13,"amount":821,"abstract":822},"cordis-marie-skłodowska-curie-actions-award-39063","Dynamical and structural properties of linear water Clusters: Long range Proton Transport in an ordered Water Phase","RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG","€157,630","The aim of this project is to provide an in depth analysis of linear water clusters, and their long range proton transport capabilities, from a quantum dynamics perspective, and to give a detailed description of their operation, in view of the envisaged technological relevance these systems may acquire in the near future. The project will first focus on the dynamical aspects of the Zundel cation, composed of two water molecules and an excess proton, the smallest system where the proton relay mec",{"id":824,"funder":7,"programme":8,"title":825,"piName":10,"institution":826,"country":12,"year":13,"amount":230,"abstract":827},"cordis-marie-skłodowska-curie-actions-award-41102","Nanocluster-sensitised optical waveguide amplifiers and lasers","UNIVERSITY OF SOUTHAMPTON","The goal of this proposal is to assess the viability of silicon-sensitised erbium doped materials systems for optical device applications. Our work will focus on silicon nanoclusters of 2-4nm diameter that possess novel optical properties, including the ability to efficiently transfer optical excitation to nearby luminescent species. We aim to exploit the optical sensitisation effects of these nanoclusters, which allow us to couple into Er ions far more effectively than is possible in convention",{"id":829,"funder":7,"programme":8,"title":830,"piName":10,"institution":831,"country":20,"year":13,"amount":832,"abstract":833},"cordis-marie-skłodowska-curie-actions-award-41732","Molecular control with tailored UV pulses","UNIVERSITE PAUL SABATIER - TOULOUSE 3","€215,156","The project aims at developing a coherent control scheme in the perturbative interaction regime by using a phase and amplitude shaped UV pump pulses and at exploiting them as a new spectroscopic tool. Pulse shaping consists in changing the Gaussian amplitude profile of femtosecond pulses by modifying both the phase relationships between the frequencies that make up the pulse and their relative amplitudes.Shaping of ultrafast pulses enabled the active control of physicochemical processes. We prop",{"id":835,"funder":7,"programme":8,"title":836,"piName":10,"institution":588,"country":12,"year":13,"amount":837,"abstract":838},"cordis-marie-skłodowska-curie-actions-award-40999","Femtosecond modifications in glasses with application to novel laser designs","€114,096","The objective of the fellowship is twofold: first, gaining new fundamental knowledge on the phenomena underlying the process of glass modification upon irradiation by femtosecond (fs) pulses, and second, application of this knowledge to optimise glass composition, the process of photo-fabrication, and finally to the design and fabrication of novel devices. Although fs writing has already been applied to create a variety of guiding structures, there is no proper understanding of its general appli",{"id":840,"funder":7,"programme":8,"title":841,"piName":10,"institution":842,"country":94,"year":13,"amount":369,"abstract":843},"cordis-marie-skłodowska-curie-actions-award-42142","B cells, splenic marginal zone, and complement -as opsonin and inflammatory mediator- in the immunopathogenesis of virally induced Type 1 Diabetes","TECHNISCHE UNIVERSITAET MUENCHEN","Approximately 150 million people are affected with diabetes mellitus worldwide. One form of diabetes, Type I diabetes, is an autoimmune disease that accounts for about 10% of all cases. It is mediated by T cells of the immune system that turn against the host (autoreactivity), and specifically destruct insulin-producing beta-cells of the pancreas. The resulting lack of insulin leads to chronic elevated blood sugar, and ultimately contributes to blindness, amputation, renal disease, and premature",{"id":845,"funder":7,"programme":8,"title":846,"piName":10,"institution":847,"country":94,"year":13,"amount":848,"abstract":849},"cordis-marie-skłodowska-curie-actions-award-42673","Political participation of European Roma Communities","BERLINER INSTITUT FÜR VERGLEICHENDE SOZIALFORSCHUNG","€1,169,060","Although there are no detailed figures available, the group of Roma, whose estimated number is around 10 million, forms the biggest ethnic minority in the EU since its enlargement. Currently, such topics as fighting exclusion and discrimination of Roma as w ell as promoting their integration and participation have been given high priority on the EU agenda. There has not, however, been much research on the political will of minorities undertaken yet, particularly pertaining to the needs of Roma c",{"id":851,"funder":7,"programme":8,"title":852,"piName":10,"institution":853,"country":20,"year":13,"amount":484,"abstract":854},"cordis-marie-skłodowska-curie-actions-award-42123","Scanning Confocal optical Microscope on-chip for lab-on-a-chip applications","UNIVERSITE DE FRANCHE-COMTE","The conventional scanning confocal microscopes are bulky bench-top instruments, not appropriate for Lab-on-a-Chip functionality, where size reduction and portability are desired. In many Lab-on-a-Chip applications (e.g. molecule recognition, monitoring of cell growth, investigation of metabolic mechanisms inside the bacteria), there is a strong need to image the molecular features by non-invasive optical methods yielding high spatial resolution and tree-dimensional reconstruction capability. How",{"id":856,"funder":7,"programme":8,"title":857,"piName":10,"institution":858,"country":20,"year":13,"amount":155,"abstract":859},"cordis-marie-skłodowska-curie-actions-award-39942","Modelling of the passive mode-locking in fibre lasers","UNIVERSITY OF ANGERS","The aim of this project is to investigate theoretically the properties of a passively mode-locked fiber laser in order to optimize a desired operating regime.Different operating regimes will be explored such as short-pulse generation in both normal and anomalous dispersion regime, generation of bunch states, generation of bound states, harmonic passive mode-locking and also Q-switching and unstable behaviours.Predictions of the model will be compared with experimental data obtained in our labora",{"id":861,"funder":7,"programme":8,"title":862,"piName":10,"institution":863,"country":20,"year":13,"amount":864,"abstract":865},"cordis-marie-skłodowska-curie-actions-award-40402","Specific molecular mechanisms as targets for novel anti-parasitic drugs","INSTITUT NATIONAL DE LA SANTé ET DE LA RECHERCHE MéDICALE","€207,742","The complete set of genes of the nuclear genome of Trypanosoma cruzi, the protozoan parasite that causes Chagas disease, can now be exploited in the search of new drugs to fight American trypanosomiasis.In this context, the work plan of this fellowship b rings together the proteomic expertise and facilities of the Institute Cochin with the expertise of Dr. Mariano J. Levin in the field of T.cruzi gene structure, expression and RNA processing, in an attempt to validate protein-protein interaction",{"id":867,"funder":7,"programme":8,"title":868,"piName":10,"institution":869,"country":12,"year":13,"amount":88,"abstract":870},"cordis-marie-skłodowska-curie-actions-award-21425","The Application of Protistan Diversity and Community Analysis, an integrated approach to Water Quality Assessment","THE NATURAL HISTORY MUSEUM","The urgent need for robust, high-throughput method to assess water quality and aquatic biodiversity, as a proxy for environmental health, are clear. This provides an obvious target for initial efforts resolving molecular fingerprints for total diversity and identification of potential indicator organisms. Eukaryotes exhibit a significant level of morphological diversity that has traditionally been used to define Linnean names. Molecular systematics provides a separate and powerful tool for phylo",{"id":872,"funder":7,"programme":8,"title":873,"piName":10,"institution":874,"country":875,"year":13,"amount":876,"abstract":877},"cordis-marie-skłodowska-curie-actions-award-18674","An expected multi-causal nature of spontaneous animal and human nephropathy in Bulgaria and South Africa","TRAKIA UNIVERSITY","BG","€184,968","The proposal has addressed porcine\u002Fchicken nephropathies in Bulgaria which are morphologically different in detail and much more prevalent than those seen in Denmark, where their first classical description was made. The same nephropathies can only partly be attributed to ochratoxin A (OTA) as their incidence in Bulgaria is higher, possibly by one to two orders of magnitude, than it was in Danish pigs in the 1960s and 70s, but the average concentrations of OTA in Bulgarian feeds for pigs\u002Fchicken",{"id":879,"funder":7,"programme":8,"title":880,"piName":10,"institution":881,"country":34,"year":13,"amount":882,"abstract":883},"cordis-marie-skłodowska-curie-actions-award-38964","Applying new genomic technologies into the field of conservation genetics","UPPSALA UNIVERSITY","€156,316","Many animals are endangered due to human activity. Large predators belong to the most vulnerable species since they usually require large natural landscape, which is rare and fragmented nowadays. Hence, the populations of most large predators are small, isolated and probably genetically impoverished. Methods used so far to analyse genetic structure and diversity of populations have drawbacks and are not easily converted to automation on large-scales. Recently, genomic research of model organisms",{"id":885,"funder":7,"programme":8,"title":886,"piName":10,"institution":887,"country":94,"year":13,"amount":888,"abstract":889},"cordis-marie-skłodowska-curie-actions-award-41060","LIFT - Laser-Induced Fluorescence Transient: a remote sensing approach to scale and quantify photosynthetic light use efficiency in ecosystems","FORSCHUNGSZENTRUM JÜLICH GMBH","€249,752","Determining the spatial and temporal diversity of photosynthetic processes of complex plant canopies presents many challenges, yet this information is required to improve carbon and climate models. The impacts of environmental stresses on the photosynthetic efficiency of leaves in the canopy have been included in current models but these parameterizations have not been properly validated. Some environmental stresses, such as low and high temperatures and excessive irradiance inhibit photosynthes",{"id":891,"funder":7,"programme":8,"title":892,"piName":10,"institution":893,"country":12,"year":13,"amount":577,"abstract":894},"cordis-marie-skłodowska-curie-actions-award-38858","Dynamic connectivity in the Motor System during tasks in health and disease","INSTITUTE OF NEUROLOGY, UNIVERSITY COLLEGE LONDON","The voluntary movement planning process involves highly complicated dynamic interactions between several key brain structures most notably the cerebral cortex, basal ganglia and cerebellum. Knowing how these interactions are affected by learning and by neurological diseases can both advance basic brain research and lead to development of new diagnostics and treatment strategies. In the recent years the group of Prof. Peter Brown has studied movement preparation by recording intracranially from p",{"id":896,"funder":7,"programme":8,"title":897,"piName":10,"institution":898,"country":12,"year":13,"amount":899,"abstract":900},"cordis-marie-skłodowska-curie-actions-award-41965","Investigation for biological samples","SWANSEA UNIVERSITY","€228,760","A multi-technique multi-disciplinary research programme is proposed addressing analysis and selective recognition of biomedical materials and cells. The research will address two aspects in the analysis of biological samples, exploiting a combination of Raman spectroscopy, SNOM and confocal microscopy:- the distinction and characterisation of micro-organisms (bacteria) for rapid turn-around analysis of infectious problems; and- the investigation of IL-13 action on cells (exemplary for immunology",{"id":902,"funder":7,"programme":8,"title":903,"piName":10,"institution":904,"country":177,"year":13,"amount":905,"abstract":906},"cordis-marie-skłodowska-curie-actions-award-21676","Canadian-Italian randomized controlled trial for the prevention of contrast nephropathy","SOCIETÀ ITALIANA DI NEFROLOGIA\u002FSIN-ERGY","€79,834","Iodinated radio-contrast media are the third most common reason for acute renal failure in hospitals (contrast nephropathy). Contrast nephropathy is mostly limited and transient, but a fraction of cases are severe enough to require dialysis, some do not re cover kidney function, while hospital stay, costs and mortality rates are all increased. To date there is no therapy for established cases.However, the likelihood of developing contrast nephropathy is strongly linked to a number of identifiabl",{"id":908,"funder":7,"programme":8,"title":909,"piName":10,"institution":910,"country":177,"year":13,"amount":911,"abstract":912},"cordis-marie-skłodowska-curie-actions-award-38734","Complexity and Quantum Invariants of 3-Manifolds and Knots","UNIVERSITÀ DI PISA","€136,375","The complexity of a 3-manifold is a certain integer that rigorously expresses an intuitive estimation of how complicated the manifold is. Being a rather natural and powerful invariant (for instance, only finitely many closed irreducible manifolds can share a given complexity), it plays an important role in dealing with one of the central problems of low-dimensional topology, namely the classification of 3-manifolds. However, its exact position with respect to the rest of 3-dimensional topology, ",{"id":914,"funder":7,"programme":8,"title":915,"piName":10,"institution":916,"country":177,"year":13,"amount":917,"abstract":918},"cordis-marie-skłodowska-curie-actions-award-46108","Translational reserach in paediatric rheumatology","ISTITUTO GIANNINA GASLINI","€355,481","Paediatric rheumatic diseases are a group of chronic disorders characterized by high morbidity that collectively represent one of the leading causes of acquired disability in childhood. They include juvenile idiopathic arthritis, juvenile systemic lupus erythematosus, juvenile dermatomyositis, juvenile scleroderma and systemic vasculitides. Translational Research in Paediatrics (TRiPR) is a coherent series of events which will aim to acquaint younger generations of European researchers and clini",{"id":920,"funder":7,"programme":8,"title":921,"piName":10,"institution":922,"country":12,"year":13,"amount":621,"abstract":923},"cordis-marie-skłodowska-curie-actions-award-42101","Types for Communicating Software Systems","THE UNIVERSITY OF NOTTINGHAM","This research directly addresses the need for software technology to develop reliable and robust communicating computer systems. It directly responds to the FP6 objective on Communication, computing and software technologies (Council decision 2002\u002F834\u002FEC) to improve the performance, reliability, cost-efficiency, functionality and adaptive capabilities of communications and computing technologies so as to meet the growing needs of application. We shall combine skills and experience from two long-",{"id":925,"funder":7,"programme":8,"title":926,"piName":10,"institution":927,"country":12,"year":13,"amount":88,"abstract":928},"cordis-marie-skłodowska-curie-actions-award-39248","Advanced Imaging and Measurement for Multiphase Flow","UNIVERSITY OF LEEDS","The principal aim of the research is to develop a new generation of a non-invasive flow instrument for the measurement of flowrates and imaging of the internal structure of complex, unsteady two- or three-phase flows. The research is multi disciplinary covering the aspects of flow mechanics and metering, process tomography, signal processing and multi-variable data fusion.   The instrument, based on electrical impedance tomography (EIT) sensors coupled with the principles of electromagnetic and ",{"id":930,"funder":7,"programme":8,"title":931,"piName":10,"institution":70,"country":20,"year":13,"amount":932,"abstract":933},"cordis-marie-skłodowska-curie-actions-award-39328","Mechanosensation of the polycystin ion-channels and their role in vascular pathology","€150,238","This project concerns the vascular physiopathology of the receptor-ion channel complex Polycystin1\u002FPolycystin2 (PC1\u002FPC2). Mutations in the PC genes PKD1 and PKD2 provoke autosomal dominant polycystic kidney disease (ADPKD). This is one of the most frequent inherited kidney diseases with a prevalence of about 1\u002F1000. Arterial hypertension, cerebral aneurysms and prolapse of the mitral valve are also associated with ADPKD.The molecular and cellular mechanisms linking PC with the cardio-vascular ph",{"id":935,"funder":7,"programme":8,"title":936,"piName":10,"institution":229,"country":12,"year":13,"amount":150,"abstract":937},"cordis-marie-skłodowska-curie-actions-award-40341","Excellent phase-change data storage materials","Today, 4.7 GB DVD discs in use are made of phase-change chalcogenides. In five years, the 1000 GB MODS discs based on the same materials are expected to be commercialized and non-volatile phase-change memories may revolutionize the next generation of laptops and digital cameras.However, as written in Nature last year: A paradoxical situation exists when a device such as an optical disc is functional and commercially available but the structural changes behind the utilized transition are unknown.",{"id":939,"funder":7,"programme":8,"title":940,"piName":10,"institution":46,"country":12,"year":13,"amount":941,"abstract":942},"cordis-marie-skłodowska-curie-actions-award-39113","Construction of new G2 manifolds using Calabi-Yau 3-folds","€162,561","We intend to study G2 manifolds and their relations with Calabi-Yau 3-folds. These are geometric objects in 6 and 7 dimensions that have been attracting much attention recently from both mathematicians working in differential geometry and from theoretical physicists studying super-string theory, super-gravity, and M-theory. We have a very clear objective in mind, to construct many new explicit examples of compact G2 manifolds starting from a Calabi-Yau 3-fold N possessing an anti-holomorphic inv",{"id":944,"funder":7,"programme":8,"title":945,"piName":10,"institution":70,"country":20,"year":13,"amount":946,"abstract":947},"cordis-marie-skłodowska-curie-actions-award-41297","Study of the oversolubility of gases in liquids of nanometric volume","€149,670","This project deals with the study of a basic phenomenon: the solubility of gases in liquids, which has many implications in physics, chemistry and engineering. What makes this proposal original is the nanometric scale of the system studied. Goals The main objective of this project is to understand why recent solubility measurements, on nanometer-scale gas\u002Fliquid systems, show values much higher than in a macroscopic bulk: what we called the oversolubility effect. A second objective is to build u",{"id":949,"funder":7,"programme":8,"title":950,"piName":10,"institution":951,"country":101,"year":13,"amount":952,"abstract":953},"cordis-marie-skłodowska-curie-actions-award-25362","Development and implementation of new conceptual density functional theory reactivity indexes and its applications to zeolites","VRIJE UNIVERSITEIT BRUSSEL","€137,216","The goal of this project is to develop and implement a new methodology in the framework of the conceptual density functional theory (DFT) and its application to chemical reactivity, with special interest to zeolites. The central quantities of conceptual DFT are the response functions. A fundamental problem arises implementing these functions, particularly the question whether energy is differentiable with respect to the number of electrons.An alternative way to evaluate these properties is using",{"id":955,"funder":7,"programme":8,"title":956,"piName":10,"institution":957,"country":94,"year":13,"amount":958,"abstract":959},"cordis-marie-skłodowska-curie-actions-award-39646","Water Vapour Exchange Study - WaVES A 3D Lagrangian Model study of Troposphere-Stratosphere exchange focusing on water vapour","ALFRED-WEGENER-INSTITUT FÜR POLAR- UND MEERESFORSCHUNG","€142,918","Current state-of-the-art modelling tools do not fully explain the observational records for stratospheric water vapour. Observed stratospheric water vapour trends can only partially be explained by increasing methane. The development of a 3D Lagrangian coupled tropospheric-stratospheric model to study water vapour transport into the stratosphere is proposed.Existing state-of-the-art capabilities will be extended by improving vertical wind transport and mixing schemes, and incorporating a microph",{"id":961,"funder":7,"programme":8,"title":962,"piName":10,"institution":963,"country":964,"year":13,"amount":178,"abstract":965},"cordis-marie-skłodowska-curie-actions-award-46367","Coastal colonization in a rapidly changing Arctic environment","INSTITUTE OF OCEANOLOGY, POLISH ACADEMY OF SCIENCES","PL","DYNARC aims to redress the paucity of knowledge of colonization processes and interactions between benthic macro-organisms in the Arctic coastal zone. The project would examine recruit variability dictated by Arctic environment dynamics. Project aims to reveal fundamental unknowns in the Arctic such as underlying structure to shallow seabed communities and diversity influences on these. Besides focus on development of new communities of Arctic marine ecosystems, DYNARC project will investigate t",{"id":967,"funder":7,"programme":8,"title":968,"piName":10,"institution":969,"country":490,"year":13,"amount":970,"abstract":971},"cordis-marie-skłodowska-curie-actions-award-41409","Linking soil biodiversity to ecosystem functioning: The role of microbes in the terrestrial climate change feedbacks","CENTRE DE RECERCA ECOLOGICA I APLICACIONS FORESTALS","€139,850","In the contest of global warming, it is important to understand the sensitivity of soil respiration to climatic changes, since it is anticipated than in a warmer world ecosystems provide a positive feedback to the greenhouse effect due to the stronger response of respiratory processes to temperature, compared to assimilatory processes. However, most of these predictions are based on empirical assumptions.To understand how terrestrial ecosystems may respond to climate change is therefore importan",{"id":973,"funder":7,"programme":8,"title":974,"piName":10,"institution":350,"country":290,"year":13,"amount":975,"abstract":976},"cordis-marie-skłodowska-curie-actions-award-41142","Impact of mesoscale dynamics and aerosols on the lifecycle of cirrus clouds","€177,217","One of the most crucial issues for predicting future climate change is the role of clouds. Clouds can warm and cool the atmosphere depending on their properties like water content, droplet size and cloud thickness. Unfortunately, our knowledge on clouds is limited and due to the insufficient representation of cloud processes in existing climate models it is difficult to predict the role of clouds in a changing climate. We want to focus on the high level clouds (cirrus clouds) consisting purely o",{"id":978,"funder":7,"programme":8,"title":979,"piName":10,"institution":980,"country":59,"year":13,"amount":981,"abstract":982},"cordis-marie-skłodowska-curie-actions-award-41606","Trophic carbon transfer efficiency under carbon dioxide stress","TECHNICAL UNIVERSITY OF DENMARK","€257,786","Current models on future climate change predict a twofold increase in atmospheric CO2 and associated decrease in oceanic pH by about 0.4 units until the end of present century. How this drastic change will affect marine ecosystem dynamics and food webs in the coastal ocean is unforeseen. Increasing evidence suggest that phytoplankton, which is at the base of the marine food web, is affected at various levels cell physiology, elemental composition and community structure - by the alteration of di",{"id":984,"funder":7,"programme":8,"title":985,"piName":10,"institution":70,"country":20,"year":13,"amount":986,"abstract":987},"cordis-marie-skłodowska-curie-actions-award-41315","Effects of global warming and alien species invasions on high diverse communities of NW Mediterranean Sea.","€157,652","Climate change and alien species invasions are leading to significant diversity loss and affect ecosystem functioning worldwide. In the NW Mediterranean the occurrence of unprecedented mass mortality events in macroinvertebrates species have been related to strong positive temperature anomalies possibly linked to climate change. On the other hand, in the Mediterranean there is an increasing number of invasive species. Up to now, most studies focus only on the effects of single disturbance source",{"id":989,"funder":7,"programme":8,"title":990,"piName":10,"institution":131,"country":94,"year":13,"amount":991,"abstract":992},"cordis-marie-skłodowska-curie-actions-award-40742","Structural studies on the HIV\u002FEIAV Encoded Transcriptional Activator Tat in complex with TAR and the cellular components, Cyclin T1 and Cdk9","€202,778","The human immunodeficiency virus (HIV) which is the retroviral causative agent of Acquired Immunodeficiency Syndrome (AIDS) has killed more than 20 million people.This proposal addresses on characterization of an important HIV-protein Tat ((transcriptional activator), which binds to transactivator response (TAR) RNA and cellular cofactors Cyclin T1 and Cdk9) involved in the transcriptional regulation of HIV replication.Inhibition of this complex formation could lead to much awaited antiviral dru",{"id":994,"funder":7,"programme":8,"title":995,"piName":10,"institution":229,"country":12,"year":13,"amount":77,"abstract":996},"cordis-marie-skłodowska-curie-actions-award-41810","Volcanic gas and aerosol emissions: ground based remote sensing, atmospheric impact and modeling of magma degassing processes","Volcanic gases and aerosols have significant impacts on the atmosphere, human health and climate. In addition they give access to deep magmatic and hydrothermal processes. Ground based optical remote sensing methods give the opportunity to measure both variations of gas compositions and fluxes.This requires the determination of the gas plume velocity, which is often approximated by wind speed and direction, inducing large errors on its estimation. Direct plume velocity measurements give more acc",{"id":998,"funder":7,"programme":8,"title":999,"piName":10,"institution":1000,"country":20,"year":13,"amount":1001,"abstract":1002},"cordis-marie-skłodowska-curie-actions-award-39401","Microbial population control in biofilm reactors for sustainable nitrogen removal from wastewater","INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE","€80,243","In the search of improving the sustainability of nitrogen removal from wastewater, techniques that convert ammonium to nitrite only (i.e., the so-called nitritation reaction) and prevent further oxidation of nitrite to nitrate, have been denoted for quite a while as very promising. The nitritation step forms the key part of innovative sustainable nitrogen removal processes, that result in lower oxygen energy requirements, less or no need for external carbon dosage, at the same time minimizing sl",{"id":1004,"funder":7,"programme":8,"title":1005,"piName":10,"institution":1006,"country":177,"year":13,"amount":1007,"abstract":1008},"cordis-marie-skłodowska-curie-actions-award-40513","Where does European law draw its authority from? Putting the European legal field back in","EUROPEAN UNIVERSITY INSTITUTE","€197,408","EUROLAWFIELD aims at providing a new conceptual framework to address empirically the following enigma: how can EU laws authority resist in a current context in which:- the Union is undergoing an unprecedented legitimacy crisis in which the central role of Law and other non-democratically elected EU actors is particularly criticized,- the cohesion of the EU-specialized legal community is jeopardized by its very success (enlargement of the EU, development of new EU legal domains and sub-fields)The",{"id":1010,"funder":7,"programme":8,"title":1011,"piName":10,"institution":1012,"country":184,"year":13,"amount":1013,"abstract":1014},"cordis-marie-skłodowska-curie-actions-award-40116","Health effects of retirement","STICHTING KATHOLIEKE UNIVERSITEIT BRABANT","€151,521","What are the health effects of the act of retiring? While this is an important question with pertinent policy consequences, little is currently known about the answer. The notion that retirement harms health is an old, and persistent hypothesis. (See Minkler 1981 for a review.)Others believe that retirement is a health-preserving life change (Eckart et al, 1983b). Despite the long-standing debate, there is little conclusive evidence thus far. The question is much more difficult to answer than wo",{"id":1016,"funder":7,"programme":8,"title":1017,"piName":10,"institution":826,"country":12,"year":13,"amount":1018,"abstract":1019},"cordis-marie-skłodowska-curie-actions-award-39950","New calibrations of the Mg\u002FCa-paleothermometer and their testing by the reconstruction of Late Pliocene paleoceanographic and paleoclimatic changes","€168,231","The proposed project consists of two parts. The objective of the first part is to calibrate the planktic foraminiferal Mg\u002FCa-paleothermometer of a shallow dwelling and a deep dwelling species using existing sediment trap and plankton net samples from the North Atlantic Ocean and Arabia Sea.The extent to which Mg\u002FCa data vary between foraminiferal genotypes and morphotypes will be assessed for the first time. The sample set used for these calibrations is unique in its absolute amount and temporal",{"id":1021,"funder":7,"programme":8,"title":1022,"piName":10,"institution":1023,"country":94,"year":13,"amount":1024,"abstract":1025},"cordis-marie-skłodowska-curie-actions-award-41105","Quasigroups, loops and related binary systems on algebraic manifolds","BAYERISCHE JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG","€103,925","The concept of quasigroups is the non- associative generalization of the concept of groups. Since the 1930's, different categories (finite, topological, analytic) of quasigroups were intensively studied. In this project, we intend to investigate algebraic quasigroups and related geometric and group theoretical structures. The adjective algebraic is meant in the sense of algebraic geometry, that is, we assume that the underlying set Q of the quasigroup is an algebraic variety and the multiplicati",{"id":1027,"funder":7,"programme":8,"title":1028,"piName":10,"institution":1029,"country":184,"year":13,"amount":1030,"abstract":1031},"cordis-marie-skłodowska-curie-actions-award-25010","Policy, law and organ procurement; can behaviour and mentalities be modified by social engineering?","RIJKSUNIVERSITEIT GRONINGEN","€142,472","It is generally agreed in the literature that the social and legal solutions until now put into practice to enhance organ donation and retrieval for transplantation have failed at fulfilling the demand for organs. Against this, some defend new solutions: markets, community ownership of corpses; production of organs in laboratories out of stem-cells or of genetically modified animals.These solutions are however socially, ethically and legally deeply unconsensual. Besides, they are defended withou",{"id":1033,"funder":7,"programme":8,"title":1034,"piName":10,"institution":1035,"country":290,"year":13,"amount":1036,"abstract":1037},"cordis-marie-skłodowska-curie-actions-award-40885","Evaluating the effects of species composition and biodiversity on ecosystem water fluxes in a changing climate","EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH","€270,003","Research addressing the effects of global change on ecosystem ecology has mainly focused on carbon cycling, while the consequences for ecosystem water pools and fluxes have received little attention. Given the important regulating role of the vegetation for ecosystem hydrology it is hypothesized that global change will not only affect ecosystem water relations directly (e.g. by altered precipitation patterns) but also indirectly through changes in plant water demand or altered plant species comp",{"id":1039,"funder":7,"programme":8,"title":1040,"piName":10,"institution":1041,"country":964,"year":13,"amount":1042,"abstract":1043},"cordis-marie-skłodowska-curie-actions-award-40613","Diversity and phylogeny of Tanaidacea form southeastern Australia","UNIVERSITY OF LODZ","€187,084","The marine fauna of southern Australia is very different from that of the rest of Australia and of other continents because of its long isolation. Its affinities are more with other Gondwanan continents (New Zealand, South America in particular) than with tropical northern Australia although elements of Indo-West Pacific fauna do occur.Its evolution suggests that no global study of a taxon can be complete without examination of the Australian fauna. The southeastern coast of Australia is an exce",{"id":1045,"funder":7,"programme":8,"title":1046,"piName":10,"institution":1047,"country":12,"year":13,"amount":14,"abstract":1048},"cordis-marie-skłodowska-curie-actions-award-41562","Zinc isotopes as tracers of nutrient cycling and carbon uptake by the past oceans","UNIVERSITY OF BRISTOL","Changes in atmospheric CO2 concentrations, recorded in ice-cores, may force up to 50% of the temperature change during Quaternary climate change. The 'biological pump', by which carbon is sequestered from the atmosphere and transferred to the deep ocean, is one of the key processes that control atmospheric carbon dioxide concentrations on these timescales. Variation in the strength of this pump is one of the most popular hypotheses to explain the ice-core data.A strengthened biological pump duri",{"id":1050,"funder":7,"programme":8,"title":1051,"piName":10,"institution":1052,"country":290,"year":13,"amount":1053,"abstract":1054},"cordis-marie-skłodowska-curie-actions-award-518768","Dynamic finite element modelling for tissue differentiation and long-term mechano-regulation processes","AO-FORSCHUNGSINSTITUT DAVOS","€167,027","A mechano-regulation computational model for musculoskeletal tissue differentiation and growth is desired to develop strategies for tissue engineering and regenerative therapies of bone and cartilage. The goal of this project is to develop and corroborate a computational adaptive model to longer-term growth of cartilage and bone in a bioreactor. Previous studies on fracture healing have demonstrated that mechanoregulation theories based on deviatoric strain and fluid flow was most promising.This",{"id":1056,"funder":7,"programme":8,"title":1057,"piName":10,"institution":1058,"country":290,"year":13,"amount":28,"abstract":1059},"cordis-marie-skłodowska-curie-actions-award-46385","Role of PTP1B in breast cancer","NOVARTIS FORSCHNUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH","In 2006 alone, an estimated 410,000 women will die from breast cancer worldwide. Improved understanding of how breast cancer arises and the factors that determine breast tumour biology are urgently needed to improve treatment options. Tyrosine phosphorylation is a reversible process, mediated by protein-tyrosine kinases and protein-tyrosine phosphatases (PTPs) that regulate critical cell signalling pathways. Abnormal tyrosine phosphorylation underlies various diseases of deregulated growth and d",{"id":1061,"funder":7,"programme":8,"title":1062,"piName":10,"institution":1063,"country":12,"year":13,"amount":1064,"abstract":1065},"cordis-marie-skłodowska-curie-actions-award-38977","Treatment of endocrine disrupting chemicals in wastewater","UNIVERSITY OF SUSSEX","€229,327","This proposal aims to support the collaboration of leading researchers to study the degradation of endocrine disrupting chemicals (EDCs), with the broad aim of supporting the development of dynamic world-class human resources in the European research system. The proposal consists of a scientific project and scientific and complimentary training.This project aims to investigate the use of ferrate, photocatalytic and photo-electrocatalytic oxidation for degrading EDCs in wastewater and to optimise",{"id":1067,"funder":7,"programme":8,"title":1068,"piName":10,"institution":1069,"country":94,"year":13,"amount":1070,"abstract":1071},"cordis-marie-skłodowska-curie-actions-award-40571","Understanding plant diversity maintenance in a multi-species metapopulation system in highly variable fire prone environment","UFZ - UMWELTFORSCHUNGSZENTRUM LEIPZIG - HALLE GMBH","€211,819","Mediterranean-climate ecosystems (e.g. Mediterranean Basin, Southwest Australia) are biodiversity hot spots for vascular plants. Some fire adapted plant species of the Proteaecae family of the South African Cape floristic region and the Southwest Australia n sandplains, which are killed by fires (non-sprouters) and storing their seeds in canopies (serotiny), are one of the rare examples of real plant metapopulations.The biodiversity of these Mediterranean ecosystems is under severe and increasin",{"id":1073,"funder":7,"programme":8,"title":1074,"piName":10,"institution":1075,"country":290,"year":13,"amount":519,"abstract":1076},"cordis-marie-skłodowska-curie-actions-award-38606","Charge compensation effects in Lanthanide assisted self-assembly","UNIVERSITE DE GENÈVE","The rational design and synthesis of pure hetero-polymetallic f-f complexes remains an unsolved chemical challenge, despite the numerous potential applications offered by their appealing electronic, photo-physical and magnetic properties for developing novel luminescent materials and sensors. The use of neutral N-donor ligands, which self-assemble into poly-lanthanide helicates on combination with appropriate Ln(III) salts, has shown substantial promise for selectively introducing different lant",{"id":1078,"funder":7,"programme":8,"title":1079,"piName":10,"institution":272,"country":59,"year":13,"amount":1080,"abstract":1081},"cordis-marie-skłodowska-curie-actions-award-41066","Spinal networks responsible for resetting the locomotor step cycle","€179,567","The mammalian spinal cord contains a neuronal network that generates rhythmic flexion and extension movements during locomotion. Sensory information on length and contraction force of extensor muscles resets the locomotor rhythm, i.e. initiates a new stance phase. Some neurons intercalated in resetting reflex pathways are also part of the rhythm generator network and studying resetting pathways can provide insights about this rhythm-generating network. The first aim of this proposal is to determ",{"id":1083,"funder":7,"programme":8,"title":1084,"piName":10,"institution":1085,"country":490,"year":13,"amount":1086,"abstract":1087},"cordis-marie-skłodowska-curie-actions-award-40691","Host Response to Baculovirus infection in Helicoverpa armigera","UNIVERSITAT DE VALENCIA","€145,232","Baculoviruses are large, double-stranded DNA viruses infecting invertebrates, mostly insects from the family Lepidoptera. They cause epizootics in pest insects and thus are regarded as promising alternatives for hazardous chemical insecticides.The application of baculoviruses; however has not yet met its potential mainly due to their relatively slow speed of action and narrow spectrum of action. Different approaches are currently undertaken to improve baculovirus pathogenicity, i.e. chemical or ",{"id":1089,"funder":7,"programme":8,"title":1090,"piName":10,"institution":1091,"country":177,"year":13,"amount":1092,"abstract":1093},"cordis-marie-skłodowska-curie-actions-award-39869","Alumina-Ti3SiC2 composites. Processing and mechanical characterization of an structural ceramic resistant to damage and solid autolubricated","NATIONAL RESEARCH COUNCIL (CONSIGLIO NAZIONALE DELLE RICERCHE)","€143,179","Ti3SiC2 has recently attracted attention due to an unusual combination of properties due to its particular layered atomic structure. In particular, it shows typical properties of ceramics (high stiffness, high strength and resistance to oxidation).On the other hand, it is quasi-plastic, relatively hard, thermal shock resistant, and under certain conditions self-lubricant. Motivated by these properties, this project will study Al2O3-Ti3SiC2 composites for structural applications. A damage toleran",{"id":1095,"funder":7,"programme":8,"title":1096,"piName":10,"institution":1097,"country":184,"year":13,"amount":1098,"abstract":1099},"cordis-marie-skłodowska-curie-actions-award-42471","Search, switching costs and the design of optimal competition policy","RIJKSUNIVERSITEIT GRONINGEN (UNIVERSITY OF GRONINGEN)","€1,159,317","In real-world markets consumers face search and switching costs. These costs have received significant theoretical consideration in separate literatures. The received wisdom is that search and switching costs have pervasive consequences in markets because they confer market power to the firms. As a result, prices are often dispersed and higher than what are desirable from a welfare standpoint. Despite a significant theoretical effort, search and switching costs are to a large extent ignored when",{"id":1101,"funder":7,"programme":8,"title":1102,"piName":10,"institution":1103,"country":12,"year":13,"amount":1104,"abstract":1105},"cordis-marie-skłodowska-curie-actions-award-41635","Implementing access control mechanisms using rewriting techniques","KING'S COLLEGE LONDON","€47,274","Static behavioural analysis of mobile computer programs is an active area of research, many fundamental behavioural properties and security issues for mobile computing have to be established. We believe that rewriting can provide a formal basis for the study of a broad range of security issues, ranging from the specification, implementation, and validation of security policies, to the analysis of logs and the development of tools for intrusion detection.In this project we will focus mainly on ac",{"id":1107,"funder":7,"programme":8,"title":1108,"piName":10,"institution":1109,"country":242,"year":13,"amount":28,"abstract":1110},"cordis-marie-skłodowska-curie-actions-award-46563","Power and rate efficient modulation in UHF-SHF multicarrier communications","TECHNICAL UNIVERSITY OF CRETE","Modern wireless communication systems intend to deliver services characterized by a demand for high data transmission rates and efficient utilization of the allocated bandwidth and energy. In conjunction with higher-layer protocols and parameters, the physical communication layer of such applications (determined by the transmission environment and transmitter\u002Freceiver design modules) critically affects the overall system performance.Besides the allocated bandwidth for each application within the",{"id":1112,"funder":7,"programme":8,"title":1113,"piName":10,"institution":1114,"country":191,"year":13,"amount":1115,"abstract":1116},"cordis-marie-skłodowska-curie-actions-award-42742","Renal macrophages as natural biosensors and therapeutic targets","MEDICAL UNIVERSITY OF VIENNA","€400,914","This proposal is designed to add value to the European science community by enhancing the research and training required to improve treatment for chronic kidney disease that is a major threat to health in Europe. If successful, it will enable Professor Rees, an internationally recognised renal immunologist from the UK to translocate to the Institute of Clinical Pathology at the Medical University of Vienna where he would establish a joint teaching and research program with Professor Kerjaschki, ",{"id":1118,"funder":7,"programme":8,"title":1119,"piName":10,"institution":1120,"country":490,"year":13,"amount":1121,"abstract":1122},"cordis-marie-skłodowska-curie-actions-award-38978","Interactive access control with Trust Management for pervasive autonomic Networks","UNIVERSIDAD DE MÁLAGA","€130,778","An autonomic network is characterized by the self-management and self-configuration of its constituent nodes. In an autonomic network each node is responsible for the management and enforcement of its own security policies with a high degree of autonomy. The major feature of an autonomic network is the on demand federation and integration of heterogeneous services with no central authority and no unified security infrastructure. This autonomic scenario poses new security challenges that require ",{"id":1124,"funder":7,"programme":8,"title":1125,"piName":10,"institution":1006,"country":177,"year":13,"amount":1126,"abstract":1127},"cordis-marie-skłodowska-curie-actions-award-39741","Europe, the USA, and the Shape of International Legal Order: A comparative study of International weapons restrictions","€114,212","The project examines the factors shaping the development of international legal norms regarding the conduct of warfare. Within this broad focus, it tries to illuminate three interrelated issues by combining insights from the fields of international relations, law, and comparative politics. The project seeks to explain the different European and US approaches to humanitarian and security problems and their impact on international humanitarian law in the post-Cold War period. Based on several case",200,{"programme":8,"total":1130,"withPiName":1131,"firstYear":1132,"lastYear":1133,"countryCount":1134,"perYear":1135,"topInstitutions":1211,"topCountries":1287},26094,19,1988,2027,53,[1136,1138,1141,1144,1147,1150,1152,1155,1158,1161,1164,1167,1170,1173,1176,1179,1182,1185,1188,1191,1194,1197,1200,1203,1206,1209],{"year":1132,"count":1137},1,{"year":1139,"count":1140},2003,74,{"year":1142,"count":1143},2004,586,{"year":1145,"count":1146},2005,868,{"year":1148,"count":1149},2006,641,{"year":13,"count":1151},553,{"year":1153,"count":1154},2008,591,{"year":1156,"count":1157},2009,712,{"year":1159,"count":1160},2010,787,{"year":1162,"count":1163},2011,838,{"year":1165,"count":1166},2012,901,{"year":1168,"count":1169},2013,1005,{"year":1171,"count":1172},2014,1009,{"year":1174,"count":1175},2015,1232,{"year":1177,"count":1178},2016,1231,{"year":1180,"count":1181},2017,1209,{"year":1183,"count":1184},2018,1353,{"year":1186,"count":1187},2019,1340,{"year":1189,"count":1190},2020,1314,{"year":1192,"count":1193},2021,1688,{"year":1195,"count":1196},2022,1362,{"year":1198,"count":1199},2023,1495,{"year":1201,"count":1202},2024,1522,{"year":1204,"count":1205},2025,1781,{"year":1207,"count":1208},2026,1532,{"year":1133,"count":1210},396,[1212,1215,1218,1221,1224,1227,1230,1233,1236,1239,1242,1245,1248,1251,1254,1257,1260,1263,1266,1269,1272,1275,1278,1281,1284],{"name":1213,"count":1214},"Centre National de la Recherche Scientifique CNRS",790,{"name":1216,"count":1217},"The Chancellor Masters and Scholars of the University of Cambridge",636,{"name":1219,"count":1220},"Kobenhavns Universitet",614,{"name":1222,"count":1223},"Chancellor, Masters and Scholars of the University of Oxford",579,{"name":1225,"count":1226},"Agencia Estatal Consejo Superior de Investigaciones Cientificas",484,{"name":1228,"count":1229},"Imperial College of Science Technology and Medicine",428,{"name":1231,"count":1232},"Max-Planck-Gesellschaft zur Forderung der Wissenschaften Ev",383,{"name":1234,"count":1235},"University of London",347,{"name":1237,"count":1238},"Katholieke Universiteit Leuven",280,{"name":1240,"count":1241},"The University of Birmingham",247,{"name":1243,"count":1244},"Eidgenoessische Technische Hochschule Zuerich",224,{"name":1246,"count":1247},"Aarhus Universitet",220,{"name":1249,"count":1250},"Universita Ca' Foscari  Venezia",219,{"name":1252,"count":1253},"University of Bristol",213,{"name":1255,"count":1256},"Ecole Polytechnique Federale de Lausanne",182,{"name":1258,"count":1259},"The University of Edinburgh",181,{"name":1261,"count":1262},"Universita Degli Studi di Padova",177,{"name":1264,"count":1265},"Universitat Wien",175,{"name":1267,"count":1268},"University of Leeds",169,{"name":1270,"count":1271},"Universiteit van Amsterdam",159,{"name":1273,"count":1274},"Universitetet I Oslo",156,{"name":1276,"count":1277},"Universiteit Utrecht",152,{"name":1279,"count":1280},"Technische Universiteit Delft",142,{"name":1282,"count":1283},"University of Warwick",141,{"name":1285,"count":1286},"Institut National de la Sante Et de la Recherche Medicale",139,[1288,1290,1292,1294,1296,1298,1300,1302,1304,1306,1308,1310,1312,1314,1317,1319,1321,1323,1325,1327,1329,1331,1334,1336,1339],{"name":12,"count":1289},5982,{"name":20,"count":1291},2854,{"name":490,"count":1293},2844,{"name":94,"count":1295},2362,{"name":177,"count":1297},2058,{"name":184,"count":1299},1624,{"name":59,"count":1301},1173,{"name":290,"count":1303},1075,{"name":101,"count":1305},996,{"name":34,"count":1307},788,{"name":191,"count":1309},634,{"name":138,"count":1311},608,{"name":471,"count":1313},487,{"name":1315,"count":1316},"PT",482,{"name":567,"count":1318},313,{"name":242,"count":1320},277,{"name":255,"count":1322},256,{"name":53,"count":1324},168,{"name":219,"count":1326},147,{"name":964,"count":1328},137,{"name":644,"count":1330},113,{"name":1332,"count":1333},"CY",99,{"name":27,"count":1335},97,{"name":1337,"count":1338},"LU",59,{"name":1340,"count":1341},"LT",56]