[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-msca-postdoctoral-fellowship-2013":3,"awarded-stats-msca-postdoctoral-fellowship":889},{"awarded":4,"total":888},[5,15,19,24,31,36,42,47,52,56,60,66,72,78,84,90,95,100,106,112,116,122,127,131,136,140,146,151,157,162,166,170,174,179,186,191,196,202,206,210,214,218,222,226,230,234,239,243,247,251,255,260,264,268,272,276,280,284,288,292,296,300,304,308,312,316,320,324,328,332,336,340,344,348,352,356,360,364,369,373,377,381,385,390,394,398,402,406,410,415,419,423,427,432,436,442,446,451,456,460,464,469,473,477,482,487,492,497,501,505,509,513,517,522,526,530,534,538,542,546,550,554,559,563,567,571,575,579,583,587,591,595,599,603,607,611,615,619,623,628,632,636,640,644,648,652,656,660,664,668,672,676,681,685,689,693,697,701,705,710,714,718,724,728,732,736,741,745,750,755,759,764,768,773,778,783,787,791,795,799,803,807,811,815,819,823,827,831,835,839,844,848,852,856,860,865,869,873,878,884],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":10,"abstract":14},"cordis-marie-skłodowska-curie-actions-award-329776","Marie Skłodowska-Curie Actions","MSCA Postdoctoral Fellowship","Myanmar freshwater biogeography; understanding a zoogeographical transition zone",null,"NATURAL HISTORY MUSEUM","UK",2013,"The tropical rivers of Asia are hotspots of freshwater fish biodiversity, yet little scientific attention has been devoted to understanding this diversity in a regional biogeographical context. One major unresolved question is the nature of the freshwater faunal break between Indian and Southeast Asian zoogeographical realms and the evolutionary relationship of species that occur in the transition zone (Myanmar) to species with more westerly and easterly geographical distributions.This project w",{"id":16,"funder":7,"programme":8,"title":17,"piName":10,"institution":11,"country":12,"year":13,"amount":10,"abstract":18},"cordis-marie-skłodowska-curie-actions-award-298920","New Insights on Micrometeorites","Micrometeorites are extraterrestrial dust particles that reach the Earth’s surface. They largely originate from comets and asteroids, the small bodies of our solar system believed to contain primordial solar system materials in a range of states of preservation. The mineralogy of these materials provides a record of their formation environment (e.g. temperatures and materials available) and\u002For subsequent parent body processing they experienced since accretion (e.g. exposure to water or heat). Th",{"id":20,"funder":7,"programme":8,"title":21,"piName":10,"institution":22,"country":10,"year":13,"amount":10,"abstract":23},"cordis-marie-skłodowska-curie-actions-award-330699","Innovative tools to examine the development of antisocial behaviour from early childhood to adolescence:  Genetically informative designs and propensity score matching","UNIVERSITY COLLEGE LONDON","Antisocial behaviour is a substantial problem in Europe: detrimental to victims, the youth, families and society as a whole. Among promising research avenues are the use of genetically informative longitudinal studies, as well as research designs aimed to determine which predictors of antisocial behaviour are causative. Using such innovative designs, my primary purpose is to provide a better understanding of the development of antisocial behaviour from early childhood to adolescence and its pred",{"id":25,"funder":7,"programme":8,"title":26,"piName":10,"institution":27,"country":28,"year":13,"amount":29,"abstract":30},"cordis-marie-skłodowska-curie-actions-award-300727","Modulating mechanisms of the onset of El Niño events","FUNDACIO INSTITUT CATALA DE CIENCIES DEL CLIMA","ES","€256,206","El Niño-Southern Oscillation is the most prominent modulator of atmospheric variability, and the major driver of climate teleconnections worldwide. It is certainly predictable, but state-of-the-art coupled models seem to have reached a plateau at moderate predictability level. Understanding the theoretical nature and activation mechanism of the phenomenon would ultimately enlarge its predictability, and in turn, improve seasonal forecasting worldwide. The present project will study the main mech",{"id":32,"funder":7,"programme":8,"title":33,"piName":10,"institution":22,"country":10,"year":13,"amount":34,"abstract":35},"cordis-marie-skłodowska-curie-actions-award-329202","Optochemical control of P2X receptor ion channels: dissecting their role in pain signalling","€282,561","Pain has a large socio-economic impact, it is estimated that up to one in five Europeans (19%) suffers from chronic pain, costing the EU around €300 billion per annum. Understanding the molecular and cellular mechanisms underlying pain signalling is critical for the development of novel treatments. P2X receptors are ligand-gated ion channels opened by extracellular ATP. They have well-established roles in chronic pain, particularly in the case of P2X3, P2X4 and P2X7 subunits. However, a lack of ",{"id":37,"funder":7,"programme":8,"title":38,"piName":10,"institution":39,"country":40,"year":13,"amount":10,"abstract":41},"cordis-marie-skłodowska-curie-actions-award-330055","Towards Long-lived and Efficient Organic Light-emitting Electrochemical Cells","Linköping University","SE","Conventional incandescent lamps are being phased out in Europe due to their low energy efficiency. Organic light-emitting electrochemical cells (OLECs) are potentially a promising alternative to them. This proposal aims to tackle two major challenges currently limiting practical applications of OLECs, i.e. their relatively short lifetime and low efficiency. The short lifetime of OLECs is due to the fact that the illumination zone is positioned close to the cathode. We have designed several exper",{"id":43,"funder":7,"programme":8,"title":44,"piName":10,"institution":45,"country":12,"year":13,"amount":10,"abstract":46},"cordis-marie-skłodowska-curie-actions-award-331294","Degradation or Empowerment? Challenging Stereotypes About Women in Porn","UNIVERSITY OF SUNDERLAND","This project aims to analyse the relation between women and (audio-visual) pornography. Since its emergence into the public sphere as a “legitimate” (i.e. not illegal) cultural form during the 1970s, pornography has alternatively been regarded as demeaning and harmful or, on the contrary, as empowering and liberating for women – at a symbolic as well as material level. On one hand, feminist anti-porn campaigns – such as those led by C. MacKinnon and A. Dworkin during the 1980s – stated the exist",{"id":48,"funder":7,"programme":8,"title":49,"piName":10,"institution":50,"country":12,"year":13,"amount":10,"abstract":51},"cordis-marie-skłodowska-curie-actions-award-301268","Modelling glacier response after Larsen B ice shelf collapse","NATURAL ENVIRONMENT RESEARCH COUNCIL","This project aims to improve our understanding of glacier and ice sheet dynamics in a warming climate, leading to a better forecast reliability for future sea level rise. The main objective is to provide more accurate estimates for the loss of grounded ice in the Antarctic Peninsula, caused by the melting and collapse of its ice shelves over the last decades. Increased losses of grounded ice have been observed at several places, in particular for the Larsen B Embayment glaciers which sped up and",{"id":53,"funder":7,"programme":8,"title":54,"piName":10,"institution":22,"country":10,"year":13,"amount":10,"abstract":55},"cordis-marie-skłodowska-curie-actions-award-327169","Islamic fashion and the politics of belonging in contemporary Turkey","This project focuses on the current articulation of the politics of belonging in Turkey and addresses an important question about regions that are ambiguous in relation to European identity and politics and the influence of contemporary Islam. In this project, Islamic fashion is considered a privileged terrain for analysis. This controversial domain is debated in relation to a series of conceptual dualities that are crucial in the formulation of the politics of belonging too, from un-veiling and",{"id":57,"funder":7,"programme":8,"title":58,"piName":10,"institution":22,"country":10,"year":13,"amount":10,"abstract":59},"cordis-marie-skłodowska-curie-actions-award-326160","Some novel Nevanlinna type results in different branches of mathematics","Fundamental results in Nevanlinna value distribution theory (one of the greatest achievements of the century, in words of Herman Weyl) and the theory of covering surfaces by Ahlfors (who was among the very first Fields medalists) complemented the list of results of general nature in the complex analysis (i.e. those results that relate to the most important and largest classes of analytic or meromorphic functions).Since 1970s several new results of similar general nature were obtained. Concerning",{"id":61,"funder":7,"programme":8,"title":62,"piName":10,"institution":63,"country":64,"year":13,"amount":10,"abstract":65},"cordis-marie-skłodowska-curie-actions-award-327088","Foreign aid and stability in the Middle East","FORSKNINGSSTIFTELSEN FAFO","NO","The overall objective of the proposed research training is to restart Beata Paragi’s career after her maternity leave and advance its development by gaining work experiences and enhancing the diversity of her skills and competences at Fafo AIS, an independent research institute in Norway. The training will strengthen the ‘researcher’ part of her academic identity building on her teaching experiences. It will help the fellow reach professional maturity as a researcher enhancing the transfer of kn",{"id":67,"funder":7,"programme":8,"title":68,"piName":10,"institution":69,"country":70,"year":13,"amount":10,"abstract":71},"cordis-marie-skłodowska-curie-actions-award-302452","Emotional prosody in speech: the importance of pitch, timing and loudness","Université Paris Descartes","FR","Prosody is the music of speech. Through variations in pitch, timing, loudness and voice quality it communicates grammatical, pragmatic, as well as affective information. The current project will focus on the acoustic cues that are important for the affective aspects of prosody, those which communicate emotion. By parametrically manipulating three acoustic cues, pitch, timing and loudness, in emotional speech samples, this project will investigate the relative importance of each of these cues in ",{"id":73,"funder":7,"programme":8,"title":74,"piName":10,"institution":75,"country":76,"year":13,"amount":10,"abstract":77},"cordis-marie-skłodowska-curie-actions-award-328536","The Birth of Diplomacy through Factions at Power: the Catholic-Spanish Party in the Imperial Court (1556-1659)","Deutsches Historisches Institut Paris","DE","The project aims to explain pre-modern diplomacy through the personal action of power elites. The researcher is concerned with a simple verification: if there is currently a widespread consensus that early modern political designs were made in the court and by courtiers, the courtier organization and acting may be scrutinized for understanding diplomatic decisions. In this respect, the proposal is as clear as it is ambitious: it endeavours to offer the first general work on the dynamics of the I",{"id":79,"funder":7,"programme":8,"title":80,"piName":10,"institution":81,"country":82,"year":13,"amount":10,"abstract":83},"cordis-marie-skłodowska-curie-actions-award-331428","Spectra of random matrices, graphs and groups","HUN-REN RENYI ALFRED MATEMATIKAI KUTATOINTEZET","HU","The goal is to understand the connections between the geometric structure of sparse (random) matrices and graphs and their spectra. Specifically, I would like to deepen the connections between three distinct research areas, each having their own set of difficult problems and open questions.The first is the study of random matrices with independent entries, started in the statistics community in the 1920s, and further developed by Wigner, Dyson and others in the 1950s and 60s; many of the results",{"id":85,"funder":7,"programme":8,"title":86,"piName":10,"institution":87,"country":88,"year":13,"amount":10,"abstract":89},"cordis-marie-skłodowska-curie-actions-award-329349","new PROcess models to simulaTE, benchmark and control Urban wastewater treatment Systems","DANMARKS TEKNISKE UNIVERSITET","DK","The objective of this project is to develop a new set of mathematical models describing some of the new focus areas\u002Fchallenges that wastewater treatment plants (WWTP) are facing nowadays. These new focus areas\u002Fchallenges include nutrient recycling & recovery, micropollutant & eco-toxicity removal and energy recovery & greenhouse gases minimization. The most innovative part of the project will rely on finding new ways to operate these facilities satisfying the new necessities by means of developi",{"id":91,"funder":7,"programme":8,"title":92,"piName":10,"institution":93,"country":70,"year":13,"amount":10,"abstract":94},"cordis-marie-skłodowska-curie-actions-award-331745","Solar cells based on InGaN nanostructures on silicon","COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES","The target of this project is the establishment of a technology platform for the fabrication of a new generation of multi-junction photovoltaic cells based on nanostructured InGaN layers synthesized on silicon substrates. Currently, the photovoltaic market is dominated by single-junction crystalline silicon modules because of their low cost and long-term reliability. However, higher conversion efficiencies are obtained using advanced multi-junction techniques operating under concentration. In th",{"id":96,"funder":7,"programme":8,"title":97,"piName":10,"institution":98,"country":76,"year":13,"amount":10,"abstract":99},"cordis-marie-skłodowska-curie-actions-award-299111","Novel conducting copolymErs for Multicolor Electrochromic DEviceS (ECDs)","FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV","One large sector of electronics industry is that of electrochromic devices (ECDs). Electrochromism is the reversible optical change in a material induced by application of an external voltage. Many inorganic and organic species show electrochromism. Conducting polymers (CPs) are a class of electrochromic materials (ECs) which gain importance rapidly, due to the combination of processability, fast response times, and high optical contrasts and the ability to modify their structure to create multi",{"id":101,"funder":7,"programme":8,"title":102,"piName":10,"institution":103,"country":104,"year":13,"amount":10,"abstract":105},"cordis-marie-skłodowska-curie-actions-award-300814","Molecular mechanisms of synapto-dendritic cargo trafficking","UNIVERSITEIT UTRECHT","NL","Activity-dependent modulation of synapses is the core mechanism of synaptic plasticity and underlies learning and memory processes in the brain. Understanding dynamic changes at synapses requires a deeper insight in the molecular machinery involved in the transport and trafficking of postsynaptic proteins. Recent studies suggest that the cytoskeleton (microtubule and actin) and molecular motors (kinesin, dynein and myosin) play an essential role in the targeting and delivery of cargos to synapse",{"id":107,"funder":7,"programme":8,"title":108,"piName":10,"institution":109,"country":110,"year":13,"amount":10,"abstract":111},"cordis-marie-skłodowska-curie-actions-award-329851","Silicon-Chip Based Efficient and Scalable Quantum Processing and Production of Photons","UNIVERSITAT WIEN","AT","The scheme of coherent photon conversion (CPC) promises to break with a single device the two main conceptual roadblocks of scalable photonic quantum information processing: the scalable creation of single photons and the implementation of a deterministic photon-photon interaction. This could bring the vision of efficient and scalable optical quantum computing within reach of current technology. Such a future working quantum computer would revolutionize many fields of science and technology.Afte",{"id":113,"funder":7,"programme":8,"title":114,"piName":10,"institution":109,"country":110,"year":13,"amount":10,"abstract":115},"cordis-marie-skłodowska-curie-actions-award-331932","Simulation of Dielectric Spectra","Modern spectroscopic techniques allow to measure the frequency dependent dielectric permittivity of complex liquids over about 18 decades, accessing relaxation times ranging from several hours down to the picosecond scale. The central problem in interpreting dielectric spectra is to relate the spectral features to the underlying dynamics of the molecular or atomic components of the fluids. Molecular dynamics simulations could provide in this sense invaluable help. However, a large number of impo",{"id":117,"funder":7,"programme":8,"title":118,"piName":10,"institution":119,"country":120,"year":13,"amount":10,"abstract":121},"cordis-marie-skłodowska-curie-actions-award-299302","Spectroscopic and computational investigation of chromium binding on pure minerals and Asopos aquifer soils","ETHNICON METSOVION POLYTECHNION","EL","This project has two parallel research objectives to transfer and expand the expertise of the U.S.-based researcher, Dr. Maria Chrysochoou to the host institution, the National Technical University of Athens (NTUA). The first objective addresses a frequent environmental problem, the mobility of hexavalent chromium (Cr(VI)) in polluted groundwater. Surface complexation modeling relies in recent years on spectroscopic and theoretical investigations of the binding mechanisms of metal contaminants o",{"id":123,"funder":7,"programme":8,"title":124,"piName":10,"institution":125,"country":104,"year":13,"amount":10,"abstract":126},"cordis-marie-skłodowska-curie-actions-award-299300","The future of geometric quantisation","STICHTING RADBOUD UNIVERSITEIT","Geometric quantisation is a fundamental link between classical and quantum mechanics, and especially between the key roles of symmetry in these types of physics. It has been studied intensively since the 1980s, and has led to important new insights into the relation between classical and quantum mechanics, and the mathematics underlying these fields. However, the way geometric quantisation has been studied so far fundamentally only applies to classical phase spaces and symmetry groups that are c",{"id":128,"funder":7,"programme":8,"title":129,"piName":10,"institution":109,"country":110,"year":13,"amount":10,"abstract":130},"cordis-marie-skłodowska-curie-actions-award-330015","Eurovision: A History of Europe through Popular Music","This project focusses on how popular music has affected and reflected cultural, political and social change in contemporary Europe through the Eurovision Song Contest. Established in 1956, Eurovision is the world’s largest popular music event and one of the most popular television programmes in Europe. As it is based on national entries, Eurovision provides case studies of how countries have imagined and branded themselves for a pan-European audience, while its voting results have been used as a",{"id":132,"funder":7,"programme":8,"title":133,"piName":10,"institution":134,"country":82,"year":13,"amount":10,"abstract":135},"cordis-marie-skłodowska-curie-actions-award-330076","Universality in the Non-Equilibrium Dynamics of Strongly Correlated Quantum Systems","BUDAPESTI MUSZAKI ES GAZDASAGTUDOMANYI EGYETEM","Compared to our understanding of equilibrium physics, the study of out of equilibrium dynamical phenomena is still in its infancy. Equilibrium systems can often be understood using mean field theory, universality and renormalisation group techniques. The situation is different away from equilibrium: there are fewer theoretical tools available, new approaches have to be developed and new organising principles have to be found.In recent years out of equilibrium systems have become the subject of i",{"id":137,"funder":7,"programme":8,"title":138,"piName":10,"institution":125,"country":104,"year":13,"amount":10,"abstract":139},"cordis-marie-skłodowska-curie-actions-award-302067","Cadherin control of invasive growth in morphogenesis and cancer","Cadherin-based cell-cell junctions regulate tissue architecture by coordinating multicellular growth and polarity.  In addition to the ubiquitously expressed and widely studied E-cadherin, epithelia express other, more tissue-specific classical cadherins, often particularly during developmental epithelial rearrangements. These additional cadherins recently  also have been implicated in tumor progression, but their expression and function is poorly understood.I recently demonstrated that differen",{"id":141,"funder":7,"programme":8,"title":142,"piName":10,"institution":143,"country":144,"year":13,"amount":10,"abstract":145},"cordis-marie-skłodowska-curie-actions-award-328605","Tailoring decoherence for controlling spin systems: Deepening foundations; expanding applications","WEIZMANN INSTITUTE OF SCIENCE","IL","During the last decades quantum control methods have developed into a central research subject in Physics. Improvements in the understanding of these quantum phenomena are also enabling the use of these effects in a growing number of applications. In particular new control methods have been emerging for extending the life of quantum states and manipulating their targeted transfers, which can influence numerous areas of application ranging from spin-based quantum computers to biological applicati",{"id":147,"funder":7,"programme":8,"title":148,"piName":10,"institution":149,"country":104,"year":13,"amount":10,"abstract":150},"cordis-marie-skłodowska-curie-actions-award-326705","Greener biological nitrogen removal: minimization of N2O emissions and optimization of the integration issues of the nitritation \u002F Anammox process for main stream wastewater treatment","TECHNISCHE UNIVERSITEIT DELFT","Effective treatment of wastewaters is one of the key actions to reduce the nutrient load of surface waters, which is one of the goals in EU policies (Water Framework Directive). There is an urgent need to develop more sustainable wastewater treatment plants (WWTP) to reduce the energy consumption and corresponding carbon dioxide (CO2) emissions. One of the keystones for the development of energy-efficient wastewater treatments is the use of an autotrophic nitrogen removal. Recently, significant ",{"id":152,"funder":7,"programme":8,"title":153,"piName":10,"institution":154,"country":155,"year":13,"amount":10,"abstract":156},"cordis-marie-skłodowska-curie-actions-award-302270","Space Debris Evolution, Collision risk, and Mitigation","POLITECNICO DI MILANO","IT","Space debris is internationally recognised as hazard to current and future space activities. This proposal will investigate the orbital dynamics of space debris through semi-analytical models of their motion under the effect of orbit perturbations. The long-term evolution will be investigated through formulations obtained by averaging techniques of the dynamics equations. This will allow a deeper insight into orbit debris evolution under the effect of natural orbit perturbations in the Earth env",{"id":158,"funder":7,"programme":8,"title":159,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":161},"cordis-marie-skłodowska-curie-actions-award-330101","The taste of volatiles: perception of odors through taste organs in Drosophila melanogaster","CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS","Taste and olfaction share the same function: detect chemicals in the external world or in food. Despite this common functionality, both systems are designed completely differently both at the level of the sensory receptors and in the way information is mapped into the brain. As such, they have been studied separately, under the common assumption that both systems are tuned to detect divergent and non-overlapping ensemble of molecules. We will challenge this view by studying taste in Drosophila, ",{"id":163,"funder":7,"programme":8,"title":164,"piName":10,"institution":98,"country":76,"year":13,"amount":10,"abstract":165},"cordis-marie-skłodowska-curie-actions-award-331430","Delivering non-viral silencing RNA (microRNA) using automated femtosecond lasers into stem cells for cardiac reprogramming and characterization using non-destructive optical techniques","Considerable focus has been placed on the influence of endogenous and exogenous interfering RNA on stem cell differentiation and behavior and substantial effort to elucidate the potential of reprogramming stem cells to guide of them towards a cardiomyogenic phenotype as a therapeutic option for heart disease. The majority of studies employ gain- or loss- of function experimental models or perform global microArrays to determine microRNAs that exhibit candidacy as governing dictators of different",{"id":167,"funder":7,"programme":8,"title":168,"piName":10,"institution":103,"country":104,"year":13,"amount":10,"abstract":169},"cordis-marie-skłodowska-curie-actions-award-331496","ER Function In Virus Infection","A major challenge in combating significant human pathogens is the inherent variation of viruses that can evolve to evade the host immune response and antiviral treatment strategies. Our research proposes an interdisciplinary approach to identify novel antiviral targets by interrogating the host cell biology of infection by influenza A virus (IAV), human immunodeficiency virus (HIV) and hepatitis C virus (HCV) using high-throughput RNA interference (RNAi) technologies. More specifically, we propo",{"id":171,"funder":7,"programme":8,"title":172,"piName":10,"institution":125,"country":104,"year":13,"amount":10,"abstract":173},"cordis-marie-skłodowska-curie-actions-award-330165","Mainstreaming Gender in the European Union after the Financial Crisis","This proposed project aims to contribute to excellence in the field of feminist political science by developing methodologies which help us to understand the gendered political dimensions of recent EU macro economic policies to the Eurozone\u002Ffinancial crisis. Gendered research on this policy area is under developed and difficult to undertake on account of well documented methodological shortcomings in feminist political science.The fellow brings an innovative methodology developed in their recent",{"id":175,"funder":7,"programme":8,"title":176,"piName":10,"institution":177,"country":40,"year":13,"amount":10,"abstract":178},"cordis-marie-skłodowska-curie-actions-award-331296","The crustacean chemosensory system: Consequences of climate and environmental change","GOETEBORGS UNIVERSITET","Although the ability to detect and respond to chemical cues is essential in most animals, we know very little of how the chemical sense will be affected by the rapid environmental changes we face today. The overall goal of this research project is to provide improved understanding of the combined impacts of climate change and pollutants on the chemosensory system of marine organisms, focusing on ecologically and economically important crustaceans. Using a combination of behavioural investigation",{"id":180,"funder":7,"programme":8,"title":181,"piName":10,"institution":182,"country":183,"year":13,"amount":184,"abstract":185},"cordis-marie-skłodowska-curie-actions-award-330803","BioElectrochemical system for Enzyme catalyzed CO2 sEquestration for the recovery of commercially viable carbonated water and methanol","VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.","BE","€177,000","Increasing energy demand and depleting fossils has put forward the necessity of searching alternatives. Recently, bioelectricity production through bioelectrochemical systems (BES) has gained prominence in the recent bioenergy scenario due to its sustainable nature. BES is electrochemical devices that convert chemical energy to electricity using biochemical pathways and redox enzymes. Enzymatic fuel cells works with the help of purified enzymes to catalyze the oxidation of fuel at the anode and ",{"id":187,"funder":7,"programme":8,"title":188,"piName":10,"institution":189,"country":183,"year":13,"amount":184,"abstract":190},"cordis-marie-skłodowska-curie-actions-award-327635","Exploring the phenotypic landscape of nectar yeasts in relation to their genetic background","KATHOLIEKE UNIVERSITEIT LEUVEN","Nectar inhabiting yeasts are increasingly considered as important third players in plant-pollinator mutualisms. Although it was generally assumed that nectar properties represent intrinsic plant features that are stable in time, it has recently been shown that nectar yeasts, may change nectar chemistry and attractiveness, and consequently pollination success and plant fitness. However, underlying mechanisms how yeasts affect pollinator behaviour and reproductive success are still poorly understo",{"id":192,"funder":7,"programme":8,"title":193,"piName":10,"institution":194,"country":155,"year":13,"amount":10,"abstract":195},"cordis-marie-skłodowska-curie-actions-award-300975","Algebraic statistics of general Markov models","UNIVERSITA DEGLI STUDI DI GENOVA","Statistical models are used in phylogenetics to recover the evolution of species. These models are generally highly complicated and the inference involves using some fragile numerical algorithms. The proposed project aims at an in-depth study of phylogenetic models from a mathematical point of view. We find it convenient to take a perspective of algebraic statistics, which is an emerging field focused on solving statistical inference problems using concepts from algebraic geometry. It allows us ",{"id":197,"funder":7,"programme":8,"title":198,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":201},"cordis-marie-skłodowska-curie-actions-award-330562","Chirped quasi-phasematching gratings for optical parametric chirped pulse amplification: physics, devices, and applications","EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH","CH","Chirped (aperiodic) quasi-phasematched (CQPM) gratings offer many advantages in the context of optical parametric chirped pulse amplification (OPCPA), including ultrabroad bandwidths, engineerable gain spectra, and potential for high efficiency via adiabatic frequency conversion. Our main goals are to investigate CQPM devices and apply them to mid-infrared OPCPA systems. We will determine the limiting factors of our current high repetition rate mid-IR OPCPA system, develop an accurate numerical ",{"id":203,"funder":7,"programme":8,"title":204,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":205},"cordis-marie-skłodowska-curie-actions-award-299035","A coupled ice sheet - ocean model for calibrated prediction of the future contribution to sea level change from the Pine Island Glacier, Antarctica","The potential of marine ice sheets to undergo rapid irreversible retreat has been considered in the glaciological community since the 1970s.  One of the world’s major marine ice sheets, the West Antarctic Ice Sheet (WAIS), contains enough ice to raise global mean sea level by approximately 5m.  However, of immediate relevance to policy makers, the likely rate of WAIS contribution to sea level change on century timescales is not known.This project will couple a state of the art ice sheet model an",{"id":207,"funder":7,"programme":8,"title":208,"piName":10,"institution":98,"country":76,"year":13,"amount":10,"abstract":209},"cordis-marie-skłodowska-curie-actions-award-327701","Plasma- and electron beam-assisted nanofabrication of two-dimensional (2D) substrates and three-dimensional (3D) scaffolds with artificial cell-instructive niches for vascular and bone implants","The project is aimed at investigation of the novel routes to prepare functional 2D-substrates or 3D-scaffolds with artificial cell-instructive niches for cardiovascular and bone implants using sophisticated plasma- and electron beam-assisted nanofabrication technologies. The project’s grand challenges are as follows:1) Plasma-assisted fabrication of two-dimensional (2D) substrates and three-dimensional (3D) scaffolds of polymers, titanium and shape-memory alloys to control the differentiation of",{"id":211,"funder":7,"programme":8,"title":212,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":213},"cordis-marie-skłodowska-curie-actions-award-302811","Multimodal Regulation of Cullin-RING Ligases by CSN","The COP9 Signalosome (CSN) is an eight-subunit molecular machine conserved in eukaryotes. Defects in CSN function are reported in human disorders and a CSN-related pathway recently emerged as a promising cancer drug target. CSN regulates embryonic development, DNA repair, cell cycle checkpoint progression and autophagy. The remarkable pleiotropy of CSN is partially explained through its enzymatic activity towards Cullin-RING E3 ubiquitin ligases (CRLs), which are activated by neddylation and ina",{"id":215,"funder":7,"programme":8,"title":216,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":217},"cordis-marie-skłodowska-curie-actions-award-326993","Talent Agents in the American Film INDustry: how cinematic careers and projects are shaped behind the scenes","This project is aimed at exploring a neglected aspect of the movie industry and of the film creation process: the role played by talent agents and its significance for the making of cultural products. Even though agents often remain unseen participants in the day-to-day functioning of the film industry, they hold a key position. This study will provide a detailed account of their professional activity, analyzing the organizational system they belong to and the interdependence mechanisms connecti",{"id":219,"funder":7,"programme":8,"title":220,"piName":10,"institution":189,"country":183,"year":13,"amount":10,"abstract":221},"cordis-marie-skłodowska-curie-actions-award-300408","EMULSION DESIGN TO IMPROVE NUTRITIONAL AND ORGANOLEPTIC QUALITY OF CEREAL BASED FOOD SYSTEMS","In light of the alarming reports on (the evolution of) the health condition of consumers in the developed world, research and food industry environments are currently investing much time and effort in the quest for ‘healthier’ food systems. However, inclusion or in situ production of bioactive compounds in food systems to improve their nutritional profile while maintaining their organoleptic properties presents real challenges.  While emulsions offer perspectives for improved food systems, conve",{"id":223,"funder":7,"programme":8,"title":224,"piName":10,"institution":103,"country":104,"year":13,"amount":10,"abstract":225},"cordis-marie-skłodowska-curie-actions-award-301938","Modeling the acquisition of phonotactics","Children learn their target language early, fast and efficiently. For instance, nine-month-old infants already display knowledge of the phonotactics of their target language, namely have been shown to react differently to licit versus illicit sound combinations. Children must thus rely on a remarkably efficient phonotactic learning procedure. What does it look like? According to the error-driven learning model, the learner maintains a current hypothesis of the target adult phonotactics and keeps",{"id":227,"funder":7,"programme":8,"title":228,"piName":10,"institution":103,"country":104,"year":13,"amount":10,"abstract":229},"cordis-marie-skłodowska-curie-actions-award-302795","Honor as a cultural mindset: Effects on cognition, emotions, and behavior in children and adults","Culture influences how people think, feel, and perceive the world around them. Two cultural axes, individualism and collectivism, have been well researched, primarily by contrasting East Asians and Westerners. Building on my previous research, I propose to examine a third and mostly neglected cultural axis, honor. Evidence of chronic accessibility of honor is most easily seen in Middle Eastern, North African and Latin cultures. Rather than focus on between-group comparisons, I propose to use the",{"id":231,"funder":7,"programme":8,"title":232,"piName":10,"institution":103,"country":104,"year":13,"amount":10,"abstract":233},"cordis-marie-skłodowska-curie-actions-award-328731","Tracing Microbes using Phosphate in Fe-oxide Environments","Acid drainage from unused mines (AMD) is a global problem. In these environments understanding the role of microbes is critical to predict its remediation as well as creation, but is also important due to its recent use as an analogue for the surface of Mars. Measuring microbial activity using isotopic signatures is a well-established idea used for AMD production, however, is typically only applicable to the metabolism of specific microbes. In contrast, fractionation in phosphate that is require",{"id":235,"funder":7,"programme":8,"title":236,"piName":10,"institution":237,"country":76,"year":13,"amount":10,"abstract":238},"cordis-marie-skłodowska-curie-actions-award-301193","The study of Hsp90 through the use of nuclear magnetic resonance, small angle scattering and calorimetry","HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH","Proper protein folding is essential for cellular homeostasis.  Cells employ a large array of chaperones to ensure protein adopt the proper conformation. Hsp90 is an important chaperone and comprises of 1-2% of all protein is eukaryotic cells.  Additionally, Hsp90 is upregulated in cancerous cells to facilitate fast proliferation.  There are several X-ray crystal structures available for Hsp90 free in solution and interacting with its target proteins.  This combined with small angle x-ray\u002Fneutron",{"id":240,"funder":7,"programme":8,"title":241,"piName":10,"institution":93,"country":70,"year":13,"amount":10,"abstract":242},"cordis-marie-skłodowska-curie-actions-award-331615","Holocene climate variability at Talos Dome, Antarctica","Polar regions are warming rapidly, but the significance of this trend can only be appreciated in the context of the long-term regional climate variability. The climate variability of Antarctica, on decadal to centennial timescales, is poorly constrained, due to the lack of long temperature time series, and we must rely on ice cores to reconstruct past temperature at high resolution. A new 1000-year temperature record at WAIS Divide, in the center of West Antarctica has highlighted the large ampl",{"id":244,"funder":7,"programme":8,"title":245,"piName":10,"institution":109,"country":110,"year":13,"amount":10,"abstract":246},"cordis-marie-skłodowska-curie-actions-award-330487","High-dimensional Multipartite Entanglement of Photonic Orbital Angular Momentum","Entanglement swapping describes a process by which two particles with no common past can be entangled with one another. Considered a key component of quantum repeater protocols, the method of entanglement swapping is also used for creating multipartite entangled states, such as Greenberger-Horne-Zeilinger (GHZ) states. To date, experimental implementations of entanglement swapping and multipartite entanglement have focused on two-dimensional or qubit entanglement. This is primarily because such ",{"id":248,"funder":7,"programme":8,"title":249,"piName":10,"institution":109,"country":110,"year":13,"amount":10,"abstract":250},"cordis-marie-skłodowska-curie-actions-award-327412","Towards rational design of cancer therapeutic drugs: a first principles study of the photosensitization mechanism of methylene blue (Photoblue)","Cancer is a severe health problem and thus the development of effective cancer drugs is one of the first priorities of the European Research Area. Photodynamic therapy (PDT) is a well-recognized process to treat cancer where cell death is caused by the effect of singlet molecular oxygen acting on molecular constituent parts of the cell. The most common way to generate singlet molecular oxygen requires the interaction between a photoexcited triplet photosensitizer and ground state molecular oxyge",{"id":252,"funder":7,"programme":8,"title":253,"piName":10,"institution":109,"country":110,"year":13,"amount":10,"abstract":254},"cordis-marie-skłodowska-curie-actions-award-299320","COral Surface MICrolayer: production and dynamics of mucus-associated microbial communities","Microbial biofilms that flourish within mucous sheets play decisive roles on the microspatial to the ecosystem scale. Coral surface mucus forms a dynamic boundary layer between the coral host epithelium and the surrounding seawater. Coral mucus sustains a diverse microbial assemblage and acts as a first barrier of defence against a wide range of environmental disturbances, thereby contributing to the health of the coral holobiont. Surprisingly, only little is known about the physical and chemica",{"id":256,"funder":7,"programme":8,"title":257,"piName":10,"institution":258,"country":76,"year":13,"amount":10,"abstract":259},"cordis-marie-skłodowska-curie-actions-award-327199","Internal Quantum Efficiency limitations in Organic Photovoltaics","JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG","Organic photovoltaics (OPV) are emerging as a potential cheap route to convert solar energy into electricity due to recent progress in the field. The global energy need makes OPV a highly strategically relevant renewable energy approach for European research and industry as very low production costs are envisaged. However, higher power conversion efficiency is paramount for making these devices attractive for the market and a much better understanding of the current principal limitations is need",{"id":261,"funder":7,"programme":8,"title":262,"piName":10,"institution":125,"country":104,"year":13,"amount":10,"abstract":263},"cordis-marie-skłodowska-curie-actions-award-331813","Focused ultrasound under magnetic resonance guidance for targeted drug delivery in the brain","Patients with brain tumours have limited treatment options and could benefit from new treatments. Focused ultrasound (FUS) combined with a microbubble agent, under guidance of magnetic resonance (MR) imaging, has been used in animal studies to temporarily open the blood-brain-barrier (BBB). The BBB normally protects the brain by blocking most substances from the blood and is a hurdle to the use of therapeutic agents in the brain. The ability to use FUS induced BBB disruption to target drugs to d",{"id":265,"funder":7,"programme":8,"title":266,"piName":10,"institution":237,"country":76,"year":13,"amount":10,"abstract":267},"cordis-marie-skłodowska-curie-actions-award-327391","Hybrid Fluorescence Optoacoustic Imaging","Optical imaging tools are in high demand by the biomedical research and clinical communities for applications that greatly impact the life sciences.The invention of fluorescent molecular tomography (FMT) a decade ago  can be considered a breakthrough in optical imaging, as it allows for unprecedented, in-vivo, non-invasive and quantitative 3D imaging of fluorescent probes. However, it has been recently shown than its performance can be greatly improved using a priori information for the tomograp",{"id":269,"funder":7,"programme":8,"title":270,"piName":10,"institution":143,"country":144,"year":13,"amount":10,"abstract":271},"cordis-marie-skłodowska-curie-actions-award-329189","Interaction of Nonlinearity and Disorder: Gateways to Optics","The project seeks to train an experienced researcher (Dr Stanislav Derevyanko) to the highest level of professional competence by bringing him into a world class research group in the field of nonlinear optics at Weizmann Institute of Science (Israel). This goal will be acheived by an ambitious research programme aimed at  elucidating the nature of the complex interplay between nonlinearity and disorder using arguably the most illustrative example where it occurs: disordered beam propagation in ",{"id":273,"funder":7,"programme":8,"title":274,"piName":10,"institution":149,"country":104,"year":13,"amount":10,"abstract":275},"cordis-marie-skłodowska-curie-actions-award-328490","New optical functions for endoscopic capsules","The passive endoscopic capsule (EC) was invented a decade ago and has proven a major technological breakthrough in medical technology that has facilitated an unprecedented level of patient-friendly diagnosis of small bowel diseases. The propulsion of commercially available passive ECs is provided by the natural motility of the intestine, known as peristalsis. Moreover, the EC vision system uses only white-light and a CMOS imager that collects the images (2-4 frames per second). Before ingestion ",{"id":277,"funder":7,"programme":8,"title":278,"piName":10,"institution":103,"country":104,"year":13,"amount":10,"abstract":279},"cordis-marie-skłodowska-curie-actions-award-303096","Defining the pathways and mechanism of misfolded protein triage and quality control in eukaryotic cells","Proteins need to be correctly folded to carry out their biological function. Failure to fold leads to aberrant protein conformations that have an increased tendency to aggregate and have deleterious effect on cell viability. Eukaryotes have developed a sophisticated protein quality control (QC) system that protects cells from misfolded or incompletely synthesized polypeptides that would otherwise interfere with normal cellular functions or even induce cellular death. The QC system may promote re",{"id":281,"funder":7,"programme":8,"title":282,"piName":10,"institution":149,"country":104,"year":13,"amount":10,"abstract":283},"cordis-marie-skłodowska-curie-actions-award-327647","Synthetic nicotinamide cofactors for new and improved biocatalytic processes","Over the past years, intensive research has been done in pursuit of the development of nicotinamide cofactor recycling systems in oxidoreductase-catalysed reactions, to reduce the overall cost of biocatalytic systems. However, there is still a need to overcome the challenging drawbacks, such as undesired side-reactions, of using these cofactor-dependent enzymes.The aim of this project is  to design and develop synthetic nicotinamide cofactors (mNADs) to be accepted by oxidoreductase enzymes and ",{"id":285,"funder":7,"programme":8,"title":286,"piName":10,"institution":154,"country":155,"year":13,"amount":10,"abstract":287},"cordis-marie-skłodowska-curie-actions-award-300077","Rapid evolutionary responses to climate change in natural populations: Integrating molecular genetics, climate predictions and demography into an eco-evolutionary modelling framework","Intensification and increased frequency of weather extremes is emerging as one of the most dramatic aspects of climate change. Thus, the study of ecological implications of global-scale changes is expanding from a focus on trends (e.g., mean temperatures)  to broader investigations including the effects of extreme events and associated catastrophic disturbances (e.g., floods, fires, droughts). However, investigations  exploring adaptations of individuals and species to altered patterns of extrem",{"id":289,"funder":7,"programme":8,"title":290,"piName":10,"institution":189,"country":183,"year":13,"amount":184,"abstract":291},"cordis-marie-skłodowska-curie-actions-award-331184","Bandgap engineering of graphene by molecular self-assembly","BENGRAS is a Marie Curie IIF project that focuses on multidisciplinary transfer of knowledge from a promising Australian early career researcher to KU Leuven towards the design and synthesis of novel functional nano-materials and the development of advanced analytical techniques for material analysis. The project will study bandgap engineering in graphene induced by physi- and chemi- sorption of self-assembled molecular monolayers, which is an interdisciplinary research topic centered at the int",{"id":293,"funder":7,"programme":8,"title":294,"piName":10,"institution":109,"country":110,"year":13,"amount":10,"abstract":295},"cordis-marie-skłodowska-curie-actions-award-326089","Conservation palaeobiology of oil-polluted tropical marine biota","The project is designed to analyze the effects of chronic pollution by off-shore oil and gas fields on marine life. During an environmental monitoring programme carried out in the southern Arabian Gulf, water, sediment and benthic marine life samples were collected in the vicinities of four fields. Pollution effects will be evaluated by classical benthic ecology methods and by an innovative approach which evaluates the agreement between the death and living assemblages: a mismatch between the co",{"id":297,"funder":7,"programme":8,"title":298,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":299},"cordis-marie-skłodowska-curie-actions-award-331816","Luminescent lanthanide dendrimer imaging agents for detection of cancer cells and tumors in vivo","Luminescence is an attractive strategy for a low cost, real-time and unambiguous detection of cancer cells and tumors due to its high sensitivity and the versatility of the instrumentation. The actual bottleneck is related to the imaging agents whose performances directly  control the sensitivity and the selectivity of the real-time detection in living biological systems. Lanthanide luminescence offers several important advantages over organic fluorophores and semiconductor nanocrystals: (i) sha",{"id":301,"funder":7,"programme":8,"title":302,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":303},"cordis-marie-skłodowska-curie-actions-award-299789","Genetic, biochemical and cell biological mechanisms of virus silencing in plants","RNA silencing pathways exist in most eukaryotes and regulate endogenes to integrate development and environmental responses, and protect organisms against foreign nucleic acids including viruses and transposons. In plants, small interfering RNA (siRNA) and microRNA (miRNA) duplexes of 21-24bp are produced from double-stranded RNA (dsRNA) precursors by Dicer-like RNaseIII enzymes (DCL1-4). Selected si\u002FmiRNA strands are then loaded into Argonaute proteins (AGO1-10), which guide an RNA-induced sile",{"id":305,"funder":7,"programme":8,"title":306,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":307},"cordis-marie-skłodowska-curie-actions-award-303088","The study of Initial limiting steps for fimbrae assembly in E.coli","Currently, the control of infectious diseases caused by pathogenic organelles displayed on bacteria is challenging for alternatives to antibiotic treatments. In this regard, the OMS report of 2010 alerted of the raising of antibiotic resistance for the control of human infections. Many of these pathogenic organelles, also known as pili or fimbriae, are assembled by a specific secretory machinery called the chaperone-usher pathway (CU). The aim of this proposal is the study of the initial steps r",{"id":309,"funder":7,"programme":8,"title":310,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":311},"cordis-marie-skłodowska-curie-actions-award-329029","Biochemical characterization of RNA silencing mechanisms and their alteration by viral proteins in plant cell-free systems","Posttranscriptional gene silencing (PTGS) is a form of small (s)RNA-mediated gene regulation with important roles in development, stress responses, and antiviral defense in plants. PTGS effectors, called RNA-induced silencing complexes (RISCs), have ARGONAUTE (AGO) proteins bound to single-stranded (ss) guide sRNAs as core components. RISCs recognize target RNA displaying complementarity to guide sRNAs, and inactivate them by endonucleolytic cleavage (or ‘slicing’) or by slicer-independent trans",{"id":313,"funder":7,"programme":8,"title":314,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":315},"cordis-marie-skłodowska-curie-actions-award-331824","Quantifying the roles that evolutionary forces play in shaping genomic and social divergence in natural populations of the cooperative bacterium Myxococcus xanthus","Our understanding of microbial genetic diversity in nature and how it relates to phenotypic divergence is extremely limited, including for social traits like those exhibited by myxobacteria. Relying on next-generation sequencing, the project proposed here seeks to quantify the roles that the forces of evolution play in shaping genomic and social divergence in natural populations of the model cooperative myxobacterium, Myxoccocus xanthus. First, I will use a global and spatially hierarchical coll",{"id":317,"funder":7,"programme":8,"title":318,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":319},"cordis-marie-skłodowska-curie-actions-award-327582","Helical Alleno-Acetylenic Oligomers with High Chiroptical Activity","The principal goal of this proposed Marie Curie project is to develop a new class of structurally-stable chiral macromolecules—alleno acetylenic oligomers—with an all-carbon backbone and rigid helical secondary structure that will result in high optical activity. We wish to explore and attain a thorough understanding of the factors that allow a significant increase in the optical activity of these materials. This will be achieved by stabilizing their secondary helical structure by the means desc",{"id":321,"funder":7,"programme":8,"title":322,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":323},"cordis-marie-skłodowska-curie-actions-award-328103","Application of Functionalised Oligoprolines in Asymmetric Catalysis","Although oligoprolines have been known for decades up till the recent years they have only been applied as spacers in the study of energy and electron transfer phenomena. Recently a new methodology for the functionalisation of their backbones has been developed. The great flexibility of the reported synthetic approach both with respect to the number and character of introduced motifs allows for effective fine-tuning of the properties of these helical oligopeptides.Herein we propose to apply func",{"id":325,"funder":7,"programme":8,"title":326,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":327},"cordis-marie-skłodowska-curie-actions-award-329935","INFLUENCE OF CLIMATE VARIABILITY ON THE DYNAMICS AND STRUCTURE OF OLD-GROWTH TEMPERATE RAINFORESTS","Many temperate forests are considered to be in an equilibrium state to which they return after a disturbance. Interactions between tree functional traits and disturbances in shaping forest composition and structure have mainly focused on spatially discrete disturbances, e.g. gaps, fire. Other disturbances occurring at relatively larger spatial scale, e.g. drought, might have diffuse but long lasting effects so that current forest structure reflects legacies from past ecological and climatic cond",{"id":329,"funder":7,"programme":8,"title":330,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":331},"cordis-marie-skłodowska-curie-actions-award-329404","Deciphering small RNA mechanisms during sexual reproduction in Arabidopsis","Sexual reproduction is a key moment in many organisms’ life cycle that ensures the proper inheritance of traits and also allows adaptation. In both plants and metazoans, reproduction entails the complex coordination of gene expression between the different tissues involved. For example, intricate modifications of epigenetic landscapes occur during and around fertilzation to ensure zygotic totipotency while maintaining genome integrity. In recent years, key connections have been established betwe",{"id":333,"funder":7,"programme":8,"title":334,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":335},"cordis-marie-skłodowska-curie-actions-award-331734","Characterizing the Phase Transitions of Single Organic Aerosols in an Optical Trap","Organic aerosols play a major role in the chemistry and physics of the atmosphere, serving as cloud condensation or ice nuclei, sites of interfacial chemistry, and scatters and absorbers of incident radiation.  Recent field campaigns have affirmed their prevalence in the troposphere, and aircraft measurements have discovered large quantities of organic material within the nuclei of ice crystals in mid-latitude mixed-phase clouds.  Despite their ubiquity and importance in the environment, little ",{"id":337,"funder":7,"programme":8,"title":338,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":339},"cordis-marie-skłodowska-curie-actions-award-326937","Global immunopeptidome landscape of normal and Mycobacterium tuberculosis-infected human cells","MHC class I-associated peptides are presented at the cell surface for scrutiny by CD8+ T lymphocytes and are collectively referred to as the immunopeptidome. The immunopeptidome plays crucial roles in many processes including autoimmunity, cancer immunosurveillance and elimination of pathogen-infected cells. Nevertheless, very little is known about the molecular composition and biogenesis of the immunopeptidome in health and disease. Through a multidisciplinary effort, I will conduct both fundam",{"id":341,"funder":7,"programme":8,"title":342,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":343},"cordis-marie-skłodowska-curie-actions-award-299666","Dynamical processes in the tropopause region and their impact on the distribution of atmospheric trace gases","This proposal outlines a research project in atmospheric sciences that addresses tropopause related processes, which contribute to chemistry-climate coupling. The tropopause region is characterized by frequent air mass exchange between the upper troposphere (UT) and lower stratosphere (LS). It is a region of significant coupling between atmospheric dynamics, chemistry, and radiation. It is therefore particularly relevant to climate. The aim of this project is to improve our ability to quantify t",{"id":345,"funder":7,"programme":8,"title":346,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":347},"cordis-marie-skłodowska-curie-actions-award-300974","Characterization of the interactions and modifications affecting AtAGO1 function","Silencing small RNAs (sRNAs) are important regulatory molecules involved in the most diverse aspects of plant physiology, including development, response to biotic and abiotic stresses, genome stability and also defense against pathogens. sRNA originate from double-strand RNAs (dsRNAs), which are processed by DICER LIKE enzymes (DCLs) to 19-24 nucleotide long sRNAs. These molecules are then loaded into ARGONAUTE (AGO) proteins to form the RNA-induced silencing complex (RISC), which drives gene s",{"id":349,"funder":7,"programme":8,"title":350,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":351},"cordis-marie-skłodowska-curie-actions-award-302364","Functional analysis of transcription factors in L-cell biology","L-cells in the intestinal epithelium are specialized enteroendocrine cells which secrete several peptide hormones after a meal, including glucagon-like peptide 1 (GLP1), oxyntomodulin (OXM) and peptide tyrosine tyrosine (PYY). These hormones are key regulators of glucose metabolism and body weight, by stimulating insulin release by pancreatic beta cells, slowing down gastric emptying and by acting on brain areas involved in body weight control. Although all three of these hormones are at least i",{"id":353,"funder":7,"programme":8,"title":354,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":355},"cordis-marie-skłodowska-curie-actions-award-330519","The Role of Atg8 Posttranslational Modifications in Autophagy","Autophagy is an important cellular degradation pathway required for eukaryotic protein homeostasis. Deregulation of autophagy has been shown to cause the development of various human pathologies, including aggregation diseases and cancer. Autophagy involves the formation of double-membrane vesicles, called autophagosomes, which sequester portions of the cytosol (general autophagy) or whole protein aggregates, organelles or pathogens (selective autophagy). Autophagosomes then fuse with the lysoso",{"id":357,"funder":7,"programme":8,"title":358,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":359},"cordis-marie-skłodowska-curie-actions-award-330524","All-Inorganic Quantum Dot Films for Photovoltaic Applications","Great progress has been achieved over the last 20 years in the colloidal synthesis of semiconductor, metallic, and magnetic nanocrystals (NCs). The state-of-the-art synthetic approaches allow obtaining inorganic nanostructures with high degree of crystallinity and precisely engineered compositions, sizes, and morphologies, while solubility in nonpolar solvents provides remarkable processability of colloidal nanomaterials. In the present time, research efforts are largely focused on the implement",{"id":361,"funder":7,"programme":8,"title":362,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":363},"cordis-marie-skłodowska-curie-actions-award-325866","QUARTERNARY STRUCTURE IMAGING WITH NANO-MAGNETIC RESONANCE IMAGING (NANO-MRI)","There are three major problems in structure determination that can be circumvented using the proposed method. First, currently available methods such as nuclear magnetic resonance, X-ray crystallography and cryo electron microscopy require averaging over thousands of identical molecules at least. Second, X-ray crystallography and cryo electron microscopy lead to radiation damage of the sample. Third, NMR and X-ray crystallography are limited to a certain molecular size or shape. Magnetic Resonan",{"id":365,"funder":7,"programme":8,"title":366,"piName":10,"institution":367,"country":76,"year":13,"amount":10,"abstract":368},"cordis-marie-skłodowska-curie-actions-award-328170","String Phenomenology at the Era of LHC","UNIVERSITAET HAMBURG","The field of research in this project is string theory and the associated phenomenological effects. The applicant aims, on one hand, to investigate how the Standard Model is embedded in orientifold vacua of string theory and establish the low energy theories of such vacua and, on the other hand, to analyse phenomenological implications of such embedding in view of new experimental data expected from LHC at CERN.The way that Standard Model is embedded in string vacua is one of the most important ",{"id":370,"funder":7,"programme":8,"title":371,"piName":10,"institution":87,"country":88,"year":13,"amount":10,"abstract":372},"cordis-marie-skłodowska-curie-actions-award-328554","Multi-scale computational fluid dynamics modelling and optimisation of the state-of-the-art solid oxide fuel cells","The presently proposed research project will be an integral part of the ongoing solid oxide fuel cell research at the Department of Energy Conversion and Storage in Technical University of Denmark (DTU Energy Conversion). DTU Energy Conversion is a world leader in research, development and commercialisation of solid oxide fuel cells.The third generation cell or metal-supported cell of DTU is currently at a more experimental stage. Here the anode support is replaced by a porous layer of ferritic ",{"id":374,"funder":7,"programme":8,"title":375,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":376},"cordis-marie-skłodowska-curie-actions-award-329875","Planet Hunting: Exploration and research at the leading edge of high-contrast imaging","The main focus of this project is to search for extrasolar planets (exoplanets) with two innovative direct imaging surveys, designed to answer a specific list of open questions in our understanding of planet formation and evolution, and making use of the best facilities and observing methods available.The SPOTS project (Search for Planets Orbiting Two Stars), initiated and led by the applicant, will survey 67 young nearby spectroscopic binary stars in search of circumbinary planets. Such targets",{"id":378,"funder":7,"programme":8,"title":379,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":380},"cordis-marie-skłodowska-curie-actions-award-326496","Causal Statistical Inference from High-Dimensional Data","Statistical causal structure learning tackles the following problem: given iid observational data from a joint distribution, we estimate the underlying causal graph. This graph contains a directed arrow from each variable to its direct effects and is assumed to be acyclic. We propose to develop methods and mathematical theory for high-dimensional applications, where the number of variables is much larger than the number of samples.Independence-based methods like the PC algorithm can discover cau",{"id":382,"funder":7,"programme":8,"title":383,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":384},"cordis-marie-skłodowska-curie-actions-award-327065","How mechanical forces regulate tissue growth in defined 3D geometries","Growth and regeneration of complex tissues are emergent phenomena resulting from the cooperative action of many cells. Besides biological signaling, the geometry of the environment plays an important role in coordinating cell behavior, and determines the shape and structure of newly formed tissue. How precisely environmental geometries are able to control cell proliferation, differentiation and extracellular matrix deposition remains a challenge. In this project, a novel in vitro model platform ",{"id":386,"funder":7,"programme":8,"title":387,"piName":10,"institution":154,"country":155,"year":13,"amount":388,"abstract":389},"cordis-marie-skłodowska-curie-actions-award-328110","Understanding photoprotection mechanisms in DNA by two-dimensional UV spectroscopy","€149,783","Since its discovery, DNA, the biomolecule that encodes the information necessary for the replication of life, has been the object of a vast amount of studies. The completed map of the human genome is a good example that illustrates the highly detailed information currently available about static properties of the DNA.  In contrast, much less is known about the dynamic properties of DNA, i.e. about those processes occurring over ultrafast timescales shorter than a picosecond.A particularly import",{"id":391,"funder":7,"programme":8,"title":392,"piName":10,"institution":199,"country":200,"year":13,"amount":10,"abstract":393},"cordis-marie-skłodowska-curie-actions-award-331171","A new equation of state for solutes in high-temperature fluids","Hot aqueous fluids are key agents in geological transport processes in the Earth’s crust, redistributing geothermal heat as well as dissolved components. Thereby, they become alternative energy resources, create valuable mineral deposit and fundamentally control the composition of the oceans. To quantitatively understand these geochemical processes requires an accurate method to evaluate the thermodynamic properties of the fluids including their dissolved components (solutes), over wide ranges o",{"id":395,"funder":7,"programme":8,"title":396,"piName":10,"institution":189,"country":183,"year":13,"amount":184,"abstract":397},"cordis-marie-skłodowska-curie-actions-award-331197","Handy natural ventilation rate calculator based on computational fluid dynamics","Considering crop and animal production, IAQ, gas emissions, associated health effects and socio-economic problems, one of the biggest issues, these days, in Europe as well as in the world is to measure the ventilation rate of naturally ventilated buildings. Among various direct and indirect methods, the CFD approach can produce the most practical and timely solutions because of its outstanding potential for analyzing complex air flows. In this project, the candidate will develop a free simulatio",{"id":399,"funder":7,"programme":8,"title":400,"piName":10,"institution":189,"country":183,"year":13,"amount":184,"abstract":401},"cordis-marie-skłodowska-curie-actions-award-330489","Cellular regulation of transient receptor potential melastatin 3 (TRPM3) and its role in skin sensation","The skin is not only a barrier between our body and the environment, but also functions as a huge sensory ‘surface’, involved in sensing various stimuli, as well as in the etiology of itch and pain. As such, the skin can be envisaged as our largest (multi)sensory organ. Ion channels of the transient receptor potential (TRP) family are considered as cellular sensors, due to their sensitivity to various physical and diverse chemical stimuli, including endogenous mediators as well as various exogen",{"id":403,"funder":7,"programme":8,"title":404,"piName":10,"institution":103,"country":104,"year":13,"amount":10,"abstract":405},"cordis-marie-skłodowska-curie-actions-award-300002","Microtubule dynamics and neuronal cargo trafficking during dendrite to axon switching","Neurons are highly polarized cells, possessing two distinct types of processes, dendrites and a single axon. In cultured mammalian neurons, axons have uniform polarity microtubules (MTs) with plus ends distal to the cell body, while dendrites have mixed polarity with about half plus-end-out and half minus-end-out MTs. Several studies suggest that neurons have a tremendous capacity for axon regeneration, even in response to total axon removal they can convert a dendrite to a regenerating axon. Th",{"id":407,"funder":7,"programme":8,"title":408,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":409},"cordis-marie-skłodowska-curie-actions-award-327616","Invasive Alien Species: towards Improved MOdeling tools through Virtual ecology","In Europe and worldwide, many plant communities are increasingly becoming dominated by introduced species. Invasive alien species (IAS) have caused severe environmental changes globally by altering species composition and ecosystem function and are considered a major threat to biodiversity. Consequently the Action Plan for Biodiversity advocates a comprehensive strategy at EU level to reduce the impact of IAS. This proposal aims to merge perspectives from plant evolutionary, functional and commu",{"id":411,"funder":7,"programme":8,"title":412,"piName":10,"institution":413,"country":120,"year":13,"amount":10,"abstract":414},"cordis-marie-skłodowska-curie-actions-award-331873","Equation of state dependence of neutron star mergers","ARISTOTELIO PANEPISTIMIO THESSALONIKIS","Mergers of neutron stars are strong emitters of gravitational waves and are among the prime targets of the upcoming gravitational wave detectors Advanced VIRGO and LIGO. Within our proposal we aim to clarify the influence of the equation of state (EoS) of neutron star matter (still largely incompletely known) on the post-merger gravitational wave signal. Understanding the dependence on the EoS can be used to determine the properties of high-density matter via the detection of gravitational waves",{"id":416,"funder":7,"programme":8,"title":417,"piName":10,"institution":103,"country":104,"year":13,"amount":10,"abstract":418},"cordis-marie-skłodowska-curie-actions-award-327282","Networking by stress signalling pathways: identification of novel regulators of combinatorial stress tolerance","Biotic and abiotic stresses are major components of natural selection in the wild. In nature, plants have to cope with a wide range of biotic and abiotic stress conditions. Recent genomics research revealed that the plant’s capacity to respond to this enormous diversity of stresses is highly flexible and finely balanced. As plants have co-evolved with an enormous variety of microbial pathogens and insect herbivores under conditions with different types of abiotic stress (heat, cold, water loggin",{"id":420,"funder":7,"programme":8,"title":421,"piName":10,"institution":119,"country":120,"year":13,"amount":10,"abstract":422},"cordis-marie-skłodowska-curie-actions-award-332028","Green Energy for Islands","Anthropogenically induced climate change is one of the most important problems the world faces today. Harmful greenhouse gas emissions must be decreased significantly in order to account for increases in the population and energy demand. Under the Europe 2020 flagship initiative for a resource-efficient Europe the Energy Efficiency Plan was adopted with the following priorities: (1) an economy that agrees with the planet’s resources, (2) low carbon systems, (3) improvement of EU energy independe",{"id":424,"funder":7,"programme":8,"title":425,"piName":10,"institution":103,"country":104,"year":13,"amount":10,"abstract":426},"cordis-marie-skłodowska-curie-actions-award-327306","New Anionic Ligands for Base Metal Catalysis","The development of catalysts based on cheap and non-toxic first-row transition metals in replacement of the traditional precious metals is broadly recognized as a key challenge for the development of environmentally friendly chemistry. Here, we propose the development of novel silicon-based ligands specifically tailored to support organometallic chemistry at first-row transition metals (Fe and Co) and their application to the mechanistic study and development of C-C bond forming reactions. The a",{"id":428,"funder":7,"programme":8,"title":429,"piName":10,"institution":430,"country":12,"year":13,"amount":10,"abstract":431},"cordis-marie-skłodowska-curie-actions-award-327846","Advanced SuperConducting devices for ENhanced infrared Detection (ASCEND)","UNIVERSITY OF GLASGOW","This Marie Curie Fellowship proposal is aimed at developing a novel type of infrared single photon detector to meet the stringent requirements of advanced imaging, quantum communications and remote sensing applications. This will be achieved by exploiting the potential of superconducting nanowire single photon detectors (SNSPDs) when detecting infrared photons of energy below 1eV. Excellent signal-to-noise ratio and timing resolution can currently be achieved in small single pixel SNSPDs of typi",{"id":433,"funder":7,"programme":8,"title":434,"piName":10,"institution":430,"country":12,"year":13,"amount":34,"abstract":435},"cordis-marie-skłodowska-curie-actions-award-331655","Microfluidics-Generated Hydrogel Particles for Protein Delivery","Controlled delivery of proteins is a highly promising strategy to treat pathological conditions, including myocardial infarcts, bone defects, and skin lesions, as well as inflammatory, metabolic and neurological disorders. A major roadblock to effective protein therapeutics is the lack of biocompatible and injectable carriers that deliver proteins with high bioactivity and suitable release profiles. The objective of this proposal is to engineer hydrogel microspheres with controlled size and prot",{"id":437,"funder":7,"programme":8,"title":438,"piName":10,"institution":439,"country":440,"year":13,"amount":10,"abstract":441},"cordis-marie-skłodowska-curie-actions-award-331065","Establishing safe, positive, inclusive school environments: The three-tiered prevention paradigm","UNIVERSITY OF CYPRUS","CY","Educating diverse students in today’s schools is an ever-increasing challenge. General education teachers in Cyprus face an increasingly diverse student body to teach. When students exhibit chronic reading and behavioural problems, the tendency is to react by initiating referrals for special education and applying stringent measures for disruptive behaviours. Soon enough, students enter a snowballing path of academic disengagement, low academic achievement, and thus they face school failure, and",{"id":443,"funder":7,"programme":8,"title":444,"piName":10,"institution":149,"country":104,"year":13,"amount":10,"abstract":445},"cordis-marie-skłodowska-curie-actions-award-300802","Strain engineering of atomically-thin nanomembrane-based electromechanical devices","In the proposed project, I will engineer the electronic and mechanical properties of freely suspended 2D crystals such as graphene by strain engineering. Although strain engineering has been aready proposed as a powerful way of fine-tuning the electrical and mechanical properties of 2D crystals to create artificial 2D materials with novel functionalities, experimental studies of the role of strain in the electromechanical properties of 2D crystals are still very scarce.In the first part of the pr",{"id":447,"funder":7,"programme":8,"title":448,"piName":10,"institution":449,"country":155,"year":13,"amount":10,"abstract":450},"cordis-marie-skłodowska-curie-actions-award-298336","THE ANTI-POLITICS OF ANTI-TRAFFICKING: A COMPARATIVE STUDY OF ANTI-TRAFFICKING POLICY AND PRACTICE IN BENIN AND ITALY","EUROPEAN UNIVERSITY INSTITUTE","During this Fellowship, I will expand my PhD research on the politics and practice of anti- human trafficking policy in Benin, by conducting a comparative study of Benin and Italy. I aim to examine whether the trends I found in Benin apply to the anti-trafficking field more generally, and my hypothesis is that they do. Specifically, I wish to investigate the way anti-trafficking policy and related discourse de-politicise human migration, fail to reflect or respond to empirics, and work to reinfo",{"id":452,"funder":7,"programme":8,"title":453,"piName":10,"institution":454,"country":40,"year":13,"amount":10,"abstract":455},"cordis-marie-skłodowska-curie-actions-award-330692","Linked analysis of viral and bacterial communities for better understanding of microbial biogeography and ecosystem functioning","UPPSALA UNIVERSITET","Despite the intensive development of microbial ecology methods in the last decades and the recognition of the importance of the linkage between viral and prokaryotic community dynamics, the two groups are rarely studied together. The present project aims to increase our understanding of the linkage between viral and prokaryotic communities in aquatic environments and initiate a framework were the two are studied together in a multidisciplinary way with special focus on the factors determining th",{"id":457,"funder":7,"programme":8,"title":458,"piName":10,"institution":454,"country":40,"year":13,"amount":10,"abstract":459},"cordis-marie-skłodowska-curie-actions-award-332265","Social Dynamics in Urban Residential Neighbourhoods. The Cases of Estonian and Swedish Cities","In many European countries extensive welfare provisions have significantly declined since the 1980s\u002F90s. The de-regulation and marketisation processes have been especially remarkable in the Central and East-European post-socialist countries. These processes have affected growing social disparities, and have often also caused the growth of socio-spatial disparities between urban neighbourhoods. Since such disparities tend to affect social integration and cohesion in societies, many countries have",{"id":461,"funder":7,"programme":8,"title":462,"piName":10,"institution":449,"country":155,"year":13,"amount":10,"abstract":463},"cordis-marie-skłodowska-curie-actions-award-326865","In the frame of party competition: citizenship, voting rights and nation-building in the post-Yugoslav space","The conflict in the post-Yugoslav space has been given considerable scholarly attention. Yet, many political processes in these states, deeply affected by the dynamics of EU accession and membership, have been neglected by the mainstream political science. Having this analytical gap in mind, this cross-disciplinary Marie Curie project analyses the effects of party competition on the relationship between citizenship and voting rights in post-Yugoslav countries with consolidated (Slovenia, Croatia",{"id":465,"funder":7,"programme":8,"title":466,"piName":10,"institution":467,"country":70,"year":13,"amount":10,"abstract":468},"cordis-marie-skłodowska-curie-actions-award-330422","Semantic integrAtion and reasoning Framework for pharmacovigilancE signals Research","INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE","Adverse drug effects endanger patients’ safety and cause considerable extra healthcare costs. The procedures of drug surveillance and drug harm prevention are studied by pharmacovigilance. Several Information Technology (IT) methods are currently employed for conducting research as regards identification of pharmacovigilance signals. The current project (SAFER) will elaborate on exploiting and complementing evidence obtained from various types of existing pharmacovigilance signal sources through",{"id":470,"funder":7,"programme":8,"title":471,"piName":10,"institution":467,"country":70,"year":13,"amount":10,"abstract":472},"cordis-marie-skłodowska-curie-actions-award-300945","Molecular mechanisms of myelination in peripheral nerves","Peripheral nerve myelination by Schwann cells is essential for normal nervous system function. Numerous acquired and inherited diseases result from defects in peripheral nerve myelination or myelin maintenance. In addition myelination is crucial for repair and regeneration of the nervous system. Thus an important challenge is to understand the cellular and molecular events that underlie myelination and myelin maintenance. The host laboratory, under the direction of Dr Nicolas Tricaud, has develo",{"id":474,"funder":7,"programme":8,"title":475,"piName":10,"institution":467,"country":70,"year":13,"amount":10,"abstract":476},"cordis-marie-skłodowska-curie-actions-award-329718","Sensory feedback in the development of motor cortex: underlying physiological network mechanisms and its relation to epileptic discharges","Early in development, spontaneous bursts of activity at the level of the spinal cord trigger spontaneous twitches of corresponding groups of muscles fibres. Twitching provides sensory feedback that generates specific neuronal oscillations in somatosensory cortex. The proposed project will address, in first line, if sensory feedback provided by spontaneous muscle twitches evokes specific patterns of neuronal activity in motor cortex. This could occur via functional projections arising from somato",{"id":478,"funder":7,"programme":8,"title":479,"piName":10,"institution":480,"country":155,"year":13,"amount":10,"abstract":481},"cordis-marie-skłodowska-curie-actions-award-331196","Ontology driven analysis of nominal systematic polysemy in WordNet","CONSIGLIO NAZIONALE DELLE RICERCHE","Our societies increasingly depend on huge amounts of textual data stored in large repositories, e.g. on the Web, in government archives, etc. Developing ways of bringing order to, and handling, this unstructured information is thus a major challenge of our times. Some of the most promising approaches for enabling computers to represent the required conceptual information appear to be ontology based ones. It is the precise path taken by this project, in application to lexical databases and WordNe",{"id":483,"funder":7,"programme":8,"title":484,"piName":10,"institution":485,"country":64,"year":13,"amount":10,"abstract":486},"cordis-marie-skłodowska-curie-actions-award-302504","THE GENETIC ARCHITECTURE OF SECONDARY SEXUAL TRAITS DURING HYBRID SPECIATION","UNIVERSITETET I OSLO","Understanding the genetic basis of phenotypic traits is of fundamental importance in evolutionary and conservation biology, but especially in the field of speciation. Hybrid speciation essentially involves fusion and stabilization of two distinct genomes accompanied by reproductive isolation from the parental counterparts. I will investigate how genetic architecture of secondary sexual traits evolves during hybrid speciation and the consequences this may have on speciation. The Italian Sparrow (",{"id":488,"funder":7,"programme":8,"title":489,"piName":10,"institution":490,"country":70,"year":13,"amount":10,"abstract":491},"cordis-marie-skłodowska-curie-actions-award-328309","Seabird population genetics, structure and biogeography","UNIVERSITE D'AIX MARSEILLE","As the global biodiversity is rapidly eroding, the preservation of species and their intra-specific diversity is an urgent challenge. Many seabirds are slipping dangerously close to extinction and seabird numbers have deteriorated faster than most other groups. Molecular methods and population modelling can be used to answer various questions important for the declining species conservation. This project has three main objectives. First, we will develop an accurate method to census seabird colon",{"id":493,"funder":7,"programme":8,"title":494,"piName":10,"institution":495,"country":12,"year":13,"amount":10,"abstract":496},"cordis-marie-skłodowska-curie-actions-award-329138","Safe green solvents for the future: in silico predictive chemometric models for selected toxicity endpoints of ionic liquids","THE UNIVERSITY OF MANCHESTER","Ionic liquids (ILs) are a modern addition to the world of chemical compounds, deployed in areas ranging from electrochemistry, over organic synthesis, to cleaning, extraction and separation technology. Their unique negligible vapor pressure, non-flammability, enhanced thermal stability and outstanding solvation potential make them ‘‘green’’ solvents. However, their toxicity needs to be understood and controlled, which is a challenge. Indeed, countless possible cation-anion combinations create bi",{"id":498,"funder":7,"programme":8,"title":499,"piName":10,"institution":495,"country":12,"year":13,"amount":10,"abstract":500},"cordis-marie-skłodowska-curie-actions-award-326032","TRANSITION METAL-NHC COMPLEXES FOR SMALL MOLECULE ACTIVATIONS","The coordination chemistry of 3d transition metals with covalently tethered N-heterocyclic carbene (NHC) ligands is almost completely unexplored. In this project, we will develop a completely new and stereo-electronically more versatile type of NHC ligand functionalized with anionic amido or phosphido donor groups. Our ligands will enable the development of a new family of three-coordinate complexes of low-valent chromium, manganese iron, cobalt and nickel, represented by 1 and 2. The three coor",{"id":502,"funder":7,"programme":8,"title":503,"piName":10,"institution":495,"country":12,"year":13,"amount":10,"abstract":504},"cordis-marie-skłodowska-curie-actions-award-328025","Magnetically responsive nanoparticle-vesicle hydrogels as smart biomaterials for the spatiotemporal control of cellular responses","This project will develop a new “smart” self-assembled biomaterial containing supramolecular magnetic nanoparticle-vesicle assemblies (MNPVs) as the active elements, which are able to convert non-invasive magnetic signals into biochemical responses in cells. This new biomaterial will have enhanced biocompatibility and allow spatiotemporal control over the release of bioactive compounds from MNPVs in the hydrogel. To achieve temporal control, a dual-release mechanism will be built into the biomat",{"id":506,"funder":7,"programme":8,"title":507,"piName":10,"institution":490,"country":70,"year":13,"amount":10,"abstract":508},"cordis-marie-skłodowska-curie-actions-award-328162","New enZymes for BIOMass carbohydrate deconstruction","Sustainable production of fuels and chemicals from biomass has become essential considering the societal and political demands for alternatives to petrochemical commodities. Efficient enzymatic conversion of plant biomass (i.e. lignocellulose) into monomeric sugars is one of the key challenges that need to be overcome. Lignocellulolytic micro-organisms, bacteria and fungi, are a reservoir for identifying new enzymes of high potential for carbohydrate modification. ZyBiom is an ambitious project ",{"id":510,"funder":7,"programme":8,"title":511,"piName":10,"institution":495,"country":12,"year":13,"amount":10,"abstract":512},"cordis-marie-skłodowska-curie-actions-award-328223","Labour trajectories in UK and Spain. Analysis of capabilities in transitions using a mixed-method approach","European labour markets are undergoing profound changes. Although the mode and extent varies between Member States according to national labour market regulations, there is a general trend towards non-standard forms of employment within the EU. The emergence of non-standard forms of employment is linked to a growing polarisation of wages and income and an expanding low-wage sector in many European countries. Theses tendencies have even been further increased by the effects of economic recession.",{"id":514,"funder":7,"programme":8,"title":515,"piName":10,"institution":495,"country":12,"year":13,"amount":10,"abstract":516},"cordis-marie-skłodowska-curie-actions-award-330354","Promoting Active Ageing: Developing Age-Friendly Cities","Need for the research: Although the issues raised by the 'age-friendly city' movement are well-understood at the level of the World Health Organisation and European Union, awareness within relevant academic disciplines is still limited. This project will fill a major gap in the literature by providing a substantial research base for assisting the development of age-friendly cities.Host and researcher: The proposed fellowship is a collaboration between a world-class scientist working at the Unive",{"id":518,"funder":7,"programme":8,"title":519,"piName":10,"institution":520,"country":28,"year":13,"amount":10,"abstract":521},"cordis-marie-skłodowska-curie-actions-award-299221","Functional evaluation of newly identified deregulated genes in Alzheimer's Disease patients using neuronal cultures and mouse model of the Disease, and possible contributions to Prion Disease","AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS","Neurodegenerative diseases (NDs) are the neurological disorders which will affect a significantly growing number of people in the context of the aging of the EU's population and worldwide. NDs thus constitute a priority for action. Alzheimer’s Disease (AD) is the most common form of dementia and ND, and a major social and health problem. Preliminary data from the host laboratory identified a subset of significantly deregulated genes in brain tissue of AD affected individuals. We here propose to ",{"id":523,"funder":7,"programme":8,"title":524,"piName":10,"institution":490,"country":70,"year":13,"amount":10,"abstract":525},"cordis-marie-skłodowska-curie-actions-award-330792","Dynamic effective connectivity of the Virtual Brain","Anatomic connections between brain areas affect information flow between neuronal circuits. However, such structural connectivity does not coincide with effective connectivity related to the more elusive question “Which areas cause the present activity of which others?”. Indeed effective connectivity depends flexibly on contexts and tasks and must be reconfigurable even when the underlying structural connectivity is fixed. Recently, computational mean-field models of whole-brain networks have re",{"id":527,"funder":7,"programme":8,"title":528,"piName":10,"institution":480,"country":155,"year":13,"amount":10,"abstract":529},"cordis-marie-skłodowska-curie-actions-award-327425","The role of the bacterial symbiont Cardinum in shaping the ecology and evolution of an insect parasitoid wasp: fundamental studies and implications for biological control of plant pests","Arthropods can be infected by facultative symbionts with diverse effects on host reproduction and fitness. Cytoplasmic reproductive incompatibility (CI) appears to be the most prevalent effect, and is caused by two unrelated bacteria: Wolbachia and the recently discovered Cardinium. Bacteria-induced CI is of special interest as it may play a role in reproductive isolation and speciation of insect hosts. Reproductive barriers can arise also by incompatibility due to hybridization (HI). Cardinium-",{"id":531,"funder":7,"programme":8,"title":532,"piName":10,"institution":495,"country":12,"year":13,"amount":10,"abstract":533},"cordis-marie-skłodowska-curie-actions-award-330603","Towards a ‘molecular factory’: Processive sequence-selective synthesis with a synthetic molecular machine","The aim of this project is to construct a synthetic molecular machine that is capable of performing a complex task, chemical synthesis, far beyond the current state-of-the-art. Our target is to mimic translation, the process through which protein is synthesized on the mRNA template by the ribosome. Although biology uses threaded molecular architectures to transfer chemical information during sequence-specific oligomer and polymer assembly, such processes are yet to be reproduced in artificial sm",{"id":535,"funder":7,"programme":8,"title":536,"piName":10,"institution":495,"country":12,"year":13,"amount":10,"abstract":537},"cordis-marie-skłodowska-curie-actions-award-329702","A zebrafish model of pancreatic neuroendocrine tumor to test resistance to antiangiogenic compounds","Neuroendocrine tumours (NETs) consist of a range of rare neoplasms that may arise from any (neuro)endocrine cell situated in any part of the human body. Despite the recent approval of two new drugs (sunitinib and everolimus) for pancreatic NETs, innate resistance is frequently encountered in these tumours and patients showing a response invariably relapse due to acquisition of resistance. Moreover, while new data are being generated, including publication of the exome sequence of pancreatic neur",{"id":539,"funder":7,"programme":8,"title":540,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":541},"cordis-marie-skłodowska-curie-actions-award-299214","Litter decomposition in forest ecosystems: assessing the functional role of climate, litter quality and soil organisms","At global scales, the carbon returned to the atmosphere through litter decomposition is a key component of the total annual carbon flux. Therefore, the study of factors controlling decomposition (climate, litter quality and soil organisms) has important implications for present and future global carbon budgets. This proposal aims to explore the relationship between biodiversity and decomposition along climatic gradients in forest ecosystems. Contrary to most previous investigations, it focuses o",{"id":543,"funder":7,"programme":8,"title":544,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":545},"cordis-marie-skłodowska-curie-actions-award-331436","Congenital heart disease-associated arrhythmia:deciphering Hamamy syndrome, novel rare disease, using iPS cells","In the growing population of patients with congenital heart defects (CHD), while arrhythmias are not a major issue for children, they are a leading complication during adulthood. My hypothesis is that the origin of some life-threatening arrhythmias in adult, lies in cardiac structural and electrophysiological development. Thus, studying causes of CHDs may reveal key steps, mis-regulated in adult patients with CHD, leading to arrhythmias.Cardiac development and adult electrical function are finel",{"id":547,"funder":7,"programme":8,"title":548,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":549},"cordis-marie-skłodowska-curie-actions-award-329818","Deciphering the role of phenolic glycolipids in mycobacterial pathogenesis","Mycobacterial diseases, like tuberculosis and leprosy, are still a threat for public health. Although antibiotherapy and BCG vaccine exist, they have failed to control these diseases. It is hence crucial to improve our knowledge of the factors involved in mycobacterial pathogenesis to design new therapies. The hallmark of mycobacterial pathogens is their ability to persist in the host by delaying the adaptive immune response. Among the mycobacterial factors suspected to play a role are phenolic ",{"id":551,"funder":7,"programme":8,"title":552,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":553},"cordis-marie-skłodowska-curie-actions-award-298073","Exact Results in Gauge Theory and Beyond","Quantum field theory plays a prominent role in our understanding of many phenomena in physics, from condensed matter physics to particle physics. The standard approach to quantum field theory relies on perturbation theory that is a powerful tool only when the system is weakly coupled and for most of the models, exact results are not accessible. This research project aims at developing and exploiting few of the recently discovered interconnections between gauge theory, string theory, 2D CFT and m",{"id":555,"funder":7,"programme":8,"title":556,"piName":10,"institution":160,"country":70,"year":13,"amount":557,"abstract":558},"cordis-marie-skłodowska-curie-actions-award-326512","Identification of p38 MAPK partners in  the response of endothelium to oxidative stress and ionizing radiation. Impact in cancer radiotherapy","€229,605","Cancer is a leading cause of death in Europe. Therefore, improving the efficacy of curative treatments remains a major goal to achieve. Today, with more than 60% of European cancer patients treated with radiotherapy, understanding the biology underlying the cellular response to ionizing radiation (IR) is an ongoing challenge to ameliorate efficacy of this treatment. Basic concepts in tumor radiobiology have evolved. Endothelium irrigating tissues exposed to radiation and signaling events initiat",{"id":560,"funder":7,"programme":8,"title":561,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":562},"cordis-marie-skłodowska-curie-actions-award-331989","Understanding the role of nuclear envelope proteins in the regulation of entiviral infectivity in non-dividing cells","One of the most striking characteristics of lentiviruses and one that distinguishes them from onco-retroviruses is their ability to infect nondividing cells. As a result, primate lentiviruses such as HIV-1 can establish a productive infection in terminally differentiated cells such as macrophages and microglia in the brain or in memory T-cells that are not cycling. The prevailing view is that those viruses are indifferent to the cell cycle status of the target cells and can infect dividing and n",{"id":564,"funder":7,"programme":8,"title":565,"piName":10,"institution":490,"country":70,"year":13,"amount":10,"abstract":566},"cordis-marie-skłodowska-curie-actions-award-299194","Optical real-time imaging of inhibitory GABAA receptors activity using chimeric GABA channel subunit","In mammalian brain the main inhibitory drive is determined by GABAergic synaptic transmission. Released from presynaptic terminals GABA activate postsynaptic Cl-selective GABAA receptors, which results in hyperpolarization of cells and inhibition of neuronal network. Dysfunction of GABAA receptors may lead to a number of pathologies, including epilepsy, Alzheimer’s disease, sleep disorders and schizophrenia. The main approach for functional analysis of GABAA receptors is represented by electroph",{"id":568,"funder":7,"programme":8,"title":569,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":570},"cordis-marie-skłodowska-curie-actions-award-330432","Regulation of alpha-v-beta-8 integrin expression and its role in intestinal immune homeostasis","Transforming growth factor-beta (TGF-b) plays a critical role in maintaining gut immune homeostasis. Although ubiquitously expressed, TGF-b must be activated in order to enable subsequent signaling. TGF-b activation thus represents a major point of regulation of intestinal immune responses.I have shown that expression of alpha-v-beta-8 integrin (avb8) by dendritic cells (DCs) is required to activate TGF-b so that it can signal to T cells. Furthermore, I have shown that avb8 expression is restric",{"id":572,"funder":7,"programme":8,"title":573,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":574},"cordis-marie-skłodowska-curie-actions-award-326794","Understanding and EXPloiting dielectric REsponse in novel Semiconducting nanoSheets","The revolutionary potential of nanoscience lies in the ability of designing new materials and functionalities for specific applications taking advantages of quantum nature of electrons. After the breakthrough discovery of graphene, the recent years have witnessed an explosive interest in two-dimensional Transition Metal Dichalcogenides nanosheets - diselenides and disulfides of transition metals, like MoS2, WS2, TiS2 and WSe2 - due their high technological potential for renewable energies, nanoe",{"id":576,"funder":7,"programme":8,"title":577,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":578},"cordis-marie-skłodowska-curie-actions-award-326054","New generation of ion sources: from deep space missions to upstream nano-technologies","The main goal of the proposed NEPTUNE project (“New generation of ion sources: from deep space missions to upstream nano-technologies”) is to enhance the understanding of the physics and exploit the benefits of bipolar charged particle extraction from low temperature plasma. The first NEPTUNE prototype will be built and tested during the project implementation. In the NEPTUNE prototype the generated particle beam will be quasi-neutral, composed by ions and electrons or oppositely charged ions, w",{"id":580,"funder":7,"programme":8,"title":581,"piName":10,"institution":495,"country":12,"year":13,"amount":10,"abstract":582},"cordis-marie-skłodowska-curie-actions-award-332210","A path to understanding: precision studies of the Higgs boson through Weak Boson Fusion","Evidence for the production of the long sought after Higgs boson has recently been presented from the ATLAS and CMS multipurpose experiments at the CERN Large Hadron Collider, at an invariant mass of approximately 125 GeV. While this represents a major achievement in and of itself, it represents only the beginning of a long programme of detailed study to investigate this new particle: its properties and their implications. The reason is two-fold: to confirm through precision study that the newly",{"id":584,"funder":7,"programme":8,"title":585,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":586},"cordis-marie-skłodowska-curie-actions-award-298457","Ecological conditions underlying the lack of lipid synthesis in parasitic insects","All organisms invest in nutrient storage to fuel energetic requirements needed for survival and reproduction. The consistency with which organisms invest in nutrient storage, in particular lipids, makes it remarkable that numerous parasitic insects lack lipid synthesis. The parasitic larval lifestyle adopted by these parasitoids has facilitated a means to carry over valuable resources from their host and allows them to refrain from costly investment in storage reserves. The lack of lipogenesis h",{"id":588,"funder":7,"programme":8,"title":589,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":590},"cordis-marie-skłodowska-curie-actions-award-330623","Quantum scattering at ultracold temperatures: a few S-matrix columns is all we need","Technology in the future will rely on the quantum nature of matter. Quantum technologies would be impossible to develop without first understanding what quantum effects have to offer. It is thus crucial to study real quantum systems, for which ultracold atomic\u002Fmolecular gases are ideal. This project is for the development and application of a novel approach to study molecular collisions at low temperatures. Its expected results will set a new standard in quantum scattering calculations and make ",{"id":592,"funder":7,"programme":8,"title":593,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":594},"cordis-marie-skłodowska-curie-actions-award-327226","In situ deformation experiments to study ductile strain localization","Plate tectonics, by linking the evolution of the Earth’s surface to the dynamics of the deep interior, has provided a coherent framework to understand the formation of mountain ranges and oil-rich sedimentary basins, as well as the distribution of major catastrophic events such as volcanic eruptions and earthquakes. We now understand that it is an essential and unique feature of mantle convection but the processes behind still remain a major open question. Strain localization at the plate scale ",{"id":596,"funder":7,"programme":8,"title":597,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":598},"cordis-marie-skłodowska-curie-actions-award-328412","Self Assembled Monolayer Tunnel Junctions Engineering with Eutectic Gallium Indium Tips","The objective of this project is to gain control on the mechanism of transport properties of Self Assembled Monolayer (SAM)-based molecular tunnel junctions. The methodology developed by the Whitesides group over the last few years has allowed to increase the reliability of molecular tunnel junctions, allowing to measure their tunnel transport rates with much more accuracy than it had been possible until now, demonstrating how SAMs of alkylthiolates on Ag with odd or even number of atoms show di",{"id":600,"funder":7,"programme":8,"title":601,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":602},"cordis-marie-skłodowska-curie-actions-award-329339","Speech monitoring as action control","The ability to produce and understand language is a complex cognitive skill whose intricate processes are often thought to be unique to humans, and it is sometimes selectively impaired following brain damage. Therefore, it has mainly been approached as an isolable faculty within the cognitive system, investigated separately from more basic faculties such as sensori-motor skills that are shared with other species. Nonetheless, recent evidence shows that sensori –motor information forms integral p",{"id":604,"funder":7,"programme":8,"title":605,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":606},"cordis-marie-skłodowska-curie-actions-award-332199","Nonlinearity-assisted Optical Focusing and Imaging Deep Inside Scattering Media","Focusing light to the (sub)micron scale is the enabling element in many important biomedical and industrial applications, such as optical microscopy and laser nano-surgery. However, the inherent inhomogeneity of biological tissues induces light scattering which limits effective focusing to shallow depths of a few hundred microns. As a result, optical microscopy, perhaps the most important tool in biological discovery and medical investigation, is currently restricted to superficial investigation",{"id":608,"funder":7,"programme":8,"title":609,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":610},"cordis-marie-skłodowska-curie-actions-award-326176","Geometrical Stochastic Signal Processing: Applications to wave Physics in random media","The research project deals with the geometry of random and disordered media at a mesoscopic level and its study from a signal processing perspective. The main application is wave physics in random and complex media.Two topical and innovative questions are addressed.1- Can we obtain a multiscale geometrical image of a random\u002Fcomplex medium from observations of waves properties at the output of the medium, using statistical measures ?2- Can we observe the dynamics of a random medium from geometric",{"id":612,"funder":7,"programme":8,"title":613,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":614},"cordis-marie-skłodowska-curie-actions-award-327954","Roles of non-coding RNAs in translational regulation during root developmental adaptation to phosphate starvation","The sessile lifestyle of plants requires them to adapt their growth and development to environmental variation. This implies a tight spatiotemporal regulation of gene expression to control developmental responses. Translational control, the regulation of the initiation, elongation or termination of ribosomes on an mRNA, provides cells additional mechanisms to rapidly control gene expression in a reversible manner, in response to environmental and developmental cues. It is known that non-coding R",{"id":616,"funder":7,"programme":8,"title":617,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":618},"cordis-marie-skłodowska-curie-actions-award-299044","EVALUATING SUCCESS OF FLOODPLAIN FOREST RESTORATION","The acknowledgment of the importance of floodplain forests and their vulnerability to human impacts has raised them as an increasing focus of interest by the environmental legislation in Europe and across the globe. As a result, huge amounts of money are being invested worldwide in their restoration. However, very few studies have reviewed the success or failure of those efforts, which raises alarming uncertainties about their effectiveness and seriously jeopardizes the fulfillment of legislatio",{"id":620,"funder":7,"programme":8,"title":621,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":622},"cordis-marie-skłodowska-curie-actions-award-330170","A study on Space and Language: Relationships between Ideograms, the Roman Alphabet, and Urban Space in the East and the West","The proposed research will investigate relationships between language and space by analyzing connections between written language and the production of urban space and architecture in the West and East. The investigation will explore language’s capacity to produce both symbolic and social dimensions of space. In doing so, the research will clarify how the differing language systems of East and West have influenced architecture design. Viewing language in a general sense—as a system of patterns, ",{"id":624,"funder":7,"programme":8,"title":625,"piName":10,"institution":626,"country":28,"year":13,"amount":10,"abstract":627},"cordis-marie-skłodowska-curie-actions-award-302603","Electron Correlation - The Electronic Ground State of Graphene Nanoribbons","UNIVERSIDAD DEL PAIS VASCO\u002F EUSKAL HERRIKO UNIBERTSITATEA","Graphene nanoribbons are derivates of graphene. Since its discovery in 2004 by Andre K. Geim and Konstantin S. Novoselov it has received enormous attention earning its discoverers the 2010 nobel prize. The great interest in graphene originates in its unique properties.Graphene nanoribbons are an interesting building block for spintronics. In standard electronics the information carrier is the charge (the electron). When a charge current is present the signal is “on”, when there is no charge curr",{"id":629,"funder":7,"programme":8,"title":630,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":631},"cordis-marie-skłodowska-curie-actions-award-327143","Quantum Dynamics of Strongly Correlated Systems and Ultra-Cold Atomic Gases","The realization of strongly correlated quantum systems by means of ultra-cold atoms is now an achieved reality.Beyond the early studies of thermodynamic equilibrium properties, these systems offer unprecedented possibilities to study their dynamics. Crucial theoretical challenges therefore concern modeling and understanding quantum dynamics in the presence of strong correlations.Our main goal is to develop new numerical approaches to tackle questions currently intractable by state-of-the-art tec",{"id":633,"funder":7,"programme":8,"title":634,"piName":10,"institution":626,"country":28,"year":13,"amount":10,"abstract":635},"cordis-marie-skłodowska-curie-actions-award-326435","First-principles theory of spatial dispersion in electromagnetic response of solids: Applications to natural optical activity and magnetoelectric effect","The global objective of the project is to develop a theoretical framework for the first-principles description of the macroscopic electromagnetic response of solids with a full and accurate account of the spatial dispersion and memory effects. The new scheme will be applied to study two fundamental properties of extended systems: the natural optical activity and the magnetoelectric effect in crystals of technological relevance, such as multiferroics and topological insulators. We should state th",{"id":637,"funder":7,"programme":8,"title":638,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":639},"cordis-marie-skłodowska-curie-actions-award-302005","Multiscattering Formalism: Casimir Effect and Related Topics","CNRS is one of the most prestigious research institutions of Europe. Research work of this project will be carried out at the “Laboratoire de Physique Theorique et Modeles Statistiques” (LPTMS) in Orsay University.In the framework of this project, the fellow will get insight on one of the more fruitful and interesting developments on Casimir effect nowadays, the multiscattering formalism of Casimir effect.In this theoretical work, the fellow, under the supervision of one of the original develope",{"id":641,"funder":7,"programme":8,"title":642,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":643},"cordis-marie-skłodowska-curie-actions-award-326608","Existence of Instabilities in Hamiltonian Systems on lattices and in Hamiltonian Partial differential equations","The study of Arnold diffusion in Hamiltonian systems has received a lot of attention in the last years. This phenomenon arises when a small perturbation in a system causes big changes in it leading to global instabilities. In recent years there have been partial results characterizing this phenomenon and proving its existence in Hamiltonian systems but mostly for systems of low dimension. This project wants to be a step forward showing that such instabilities also arise in Dynamical Systems on l",{"id":645,"funder":7,"programme":8,"title":646,"piName":10,"institution":467,"country":70,"year":13,"amount":10,"abstract":647},"cordis-marie-skłodowska-curie-actions-award-301671","Origin and function of nonrandom cortical connectivities","Recent neurophysiological experiments have revealed the existence of nonrandom connectivity patterns in the cortex of rats. These patterns consist of certain connectivity structures that appear more often than one would expect if neurons were randomly connected. An example of such departure from randomness is the prevalence of pairs of neurons reciprocally connected. Another example is the overrepresentation of certain connectivity patterns involving three or more neurons connected through stron",{"id":649,"funder":7,"programme":8,"title":650,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":651},"cordis-marie-skłodowska-curie-actions-award-328319","Assessing the variability of the first Anatomically Modern Humans behavior: Human \u002F environment interaction in Western Europe and South Africa  (60,000 – 40,000 years B.P.)","This project targets the shift and variability of human adaptive systems in the scope of the dispersion of the Anatomically Modern Humans (AMHs), from the African continent to throughout Eurasia 60,000 years ago.This dispersion was accompanied by new technical, social and territorial organizations that characterize the Upper Paleolithic material culture. Much research has focused on the recent stages of these modern human populations (25,000 B.P.) of East and Central Europe.There is still little",{"id":653,"funder":7,"programme":8,"title":654,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":655},"cordis-marie-skłodowska-curie-actions-award-327377","Chromatin dynamics for gene activation in the developing flower","This proposal for a career development fellowship aims to assist a young researcher in achieving an independent position in the ERA. To reach this goal, we suggest the following project to decipher the molecular events taking place at plant chromatin during gene activation. Highly flexible plant cell fates allow life-long organogenesis, thus providing adequate models to study developmental processes. Differentiation of small stem cell clusters requires activation of developmental factors to foll",{"id":657,"funder":7,"programme":8,"title":658,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":659},"cordis-marie-skłodowska-curie-actions-award-328282","CorpAGEst. A corpus-based multimodal approach to the pragmatic competence of the elderly","This research project aims to establish the gestural and verbal profile of very old people in normal aging, looking at their pragmatic competence from a naturalistic and ecological perspective. To reach this goal, a multimodal corpus (integrating text, sound, and gesture) will serve to carry out corpus-based analyses with the aim of testing several hypotheses: (i) a change in the use of (inter)subjective verbal markers (e.g., tu sais\u002Fvous savez ‘you know’) could be an indicator of a change in th",{"id":661,"funder":7,"programme":8,"title":662,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":663},"cordis-marie-skłodowska-curie-actions-award-328078","Mastering novel switchable molecular materials at the nanometric scale for their technological application in the areas of nanoelectronics and nanophotonics","NanoSCOpe aims at supporting the career development of the candidate by means of a training-through-research project in which the coordination chemistry and physical characterization at the molecular level expertise of the applicant will be combined with the nanotechnology, physical-chemistry, nanophotonics and nanoelectronics expertise of the host institution for handling novel SCO-based switchable molecular materials at the nanoscopic scale as required for their technological application.The m",{"id":665,"funder":7,"programme":8,"title":666,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":667},"cordis-marie-skłodowska-curie-actions-award-326442","DEEP BRAIN TISSUE IMAGING OF GLUTAMATE NMDAR","Unrevealing the rules that govern the surface trafficking and membrane stabilization of neurotransmitter receptors, in particular the NMDAR is crucial for our understanding of several physiopathological brain processes. Over the past few years, scientists have shown that neurotransmitter receptors diffuse inside and out of synapses in cultured neurons using single molecule approaches. These findings drastically changed the way we understand synaptic transmission and adaptation. The proposed proj",{"id":669,"funder":7,"programme":8,"title":670,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":671},"cordis-marie-skłodowska-curie-actions-award-300948","Aromatic oligoamide foldamers as mimics of double helical DNA","The aim of this project is to design and synthesize helically folded aromatic oligoamides that chemically and structurally mimic the surface of double stranded DNA. The potency of these foldamers to interact with DNA processing enzymes relevant in cancer therapy will be assessed in order to establish structure-activity relationships. The research program primarily involves the chemical synthesis of novel anion bearing foldamers as well as structural investigations",{"id":673,"funder":7,"programme":8,"title":674,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":675},"cordis-marie-skłodowska-curie-actions-award-327586","Predictable Rhythm in Speech - Benefits for Perception and Production","What comes next? We are constantly asking this question – whether in times of economical crisis, when crossing a street or when having an argument with someone. Making predictions about future events is essential for adapting our social actions. In the auditory domain, regular rhythmic patterns allow most efficiently to make predictions. Findings show that regular rhythm enhances memory, monitoring and processing of sound. While most of this research was done in cognitive sciences, studies are r",{"id":677,"funder":7,"programme":8,"title":678,"piName":10,"institution":679,"country":120,"year":13,"amount":10,"abstract":680},"cordis-marie-skłodowska-curie-actions-award-302898","Sparse Online Learning","ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON","The emerging theory of Compressed Sensing (CS), changed the very essence of our thinking about signal recovery, system identification and parameter vector estimation.  Since its debut only a few years ago, CS attracted considerable research interest with thousands of papers spanning along the Mathematical, Machine Learning and Signal Processing communities. This ``research happening'' gave birth to many significant contributions bringing the CS paradigm closer to a wide range of real-world appli",{"id":682,"funder":7,"programme":8,"title":683,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":684},"cordis-marie-skłodowska-curie-actions-award-330735","Molecular origins of electrochemical energy storage properties in lithium-ion batteries and supercapacitors","The need for materials with improved electrochemical energy storage properties has become increasingly critical as society grapples with limited fossil fuel reserves and the threat of climate change. Lithium-ion batteries and supercapacitors are related energy storage systems that store energy electrochemically. Recently, researchers have shown that amorphous structures, defects, non-stoichiometric domains, interfaces between components, and surface modifications may play critical roles in their",{"id":686,"funder":7,"programme":8,"title":687,"piName":10,"institution":490,"country":70,"year":13,"amount":10,"abstract":688},"cordis-marie-skłodowska-curie-actions-award-326370","Normative Interaction and Law-Making: Regulating Migration in the Maghreb","This project explores law-making in the domain of migration in the Maghreb as a result of interaction between diverse exogenous and endogenous normative factors. It builds and tests an innovative approach to reforms undertaken since 2003 in three countries, namely Tunisia, Morocco and Mauritania, to improve the knowledge and understanding of legal development in the Maghreb. It unfolds the plurality of interactions that result in the law being reformed in these countries and the country-specific",{"id":690,"funder":7,"programme":8,"title":691,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":692},"cordis-marie-skłodowska-curie-actions-award-331576","Overdominance: from spontaneous mutations to balancing selection in natural populations","Overdominance occurs when individuals carrying two different alleles at a specific locus have higher Darwinian fitness than both homozygotes, who carry only one allele. It is involved in a range of observations in genetics and evolution (e.g. genetic diversity, inbreeding depression, heterosis)  and has been controversial for over a century. Empirical studies on the frequency of spontaneous mutations causing overdominance are scarce and there has been no systematic effort to screen for overdomin",{"id":694,"funder":7,"programme":8,"title":695,"piName":10,"institution":679,"country":120,"year":13,"amount":10,"abstract":696},"cordis-marie-skłodowska-curie-actions-award-326060","URBAN RECREATION: Energy efficient retrofit for carbon zero and socio-oriented urban environments","Appropriate strategies to reduce energy consumption, increase Renewable Energy Sources (RES) penetration within local urban ecosystems seems to be the high priorities towards low carbon cities. In this context urban canyons (UCs) represent the core of the search for new intersections between energy issues and urban dwellers.The goal of the proposal is to demonstrate the techno-economical and social feasibility of zero energy-zero emission retrofit in existing UCs. To reach this aim the research ",{"id":698,"funder":7,"programme":8,"title":699,"piName":10,"institution":160,"country":70,"year":13,"amount":10,"abstract":700},"cordis-marie-skłodowska-curie-actions-award-327778","Assisted Migration of Forests as a climate change economic mitigation strategy","Adapting forests to climate change in a sustainable way is one of the most difficult challenges faced by scientists because of the uncertainty of climate change, and the pressures imposed to managers to act today that cannot be ignored. The main purpose of our proposal is to provide new ecological, economic and legal tools to address adaptation and mitigation of forests to climate change at the national (France) and European level.A fundamental problem is the management practices to mitigate the",{"id":702,"funder":7,"programme":8,"title":703,"piName":10,"institution":480,"country":155,"year":13,"amount":10,"abstract":704},"cordis-marie-skłodowska-curie-actions-award-326641","Experimental STation for the Analysis of the Spin dYnamics","The aim of the project is the development of an experimental station for performing experiments on the magnetic properties of materials thanks to the spin analysis of the photoelectrons. This goal will be achieved with the construction of a new UHV station that will be equipped with a vectorial mott detector apparatus already present at the TASC laboratory. The actual mott detector system will be implemented with new electronics and new acquisition software that will permit to perform time resol",{"id":706,"funder":7,"programme":8,"title":707,"piName":10,"institution":708,"country":40,"year":13,"amount":10,"abstract":709},"cordis-marie-skłodowska-curie-actions-award-332428","Nudix hydrolases in Cancer Therapy","KAROLINSKA INSTITUTET","Cancer is the activation of dysfunctional pathways leading to abnormal behaviour of cells. A hallmark of cancer is genomic instability, triggered by a range of DNA lesions such as 8-oxo-G, caused by reactive oxygen species (ROS). ROS are generated by the cell’s metabolism and are crucial for its homeostasis. However, excessive ROS levels can induce DNA lesions resulting in increased mutations, fuelling genetic instability favouring carcinogenesis. Free dNTP are more easily damaged by ROS and are",{"id":711,"funder":7,"programme":8,"title":712,"piName":10,"institution":708,"country":40,"year":13,"amount":10,"abstract":713},"cordis-marie-skłodowska-curie-actions-award-326903","Size Matters: investigating the link between affective and perceptual body representations using multisensory illusions and brain imaging","The perceptual flexibility of the human body representation has been well documented, demonstrating that changes to our body can be quickly adapted to by the brain. However, how this affects our emotional feeling towards our body is yet to be explored. Negative feelings towards our body can have catastrophic consequences for our mental and physical health being associated with disordered eating behaviour such as anorexia and bulimia nervosa. The proposed research aims to investigate affective co",{"id":715,"funder":7,"programme":8,"title":716,"piName":10,"institution":708,"country":40,"year":13,"amount":10,"abstract":717},"cordis-marie-skłodowska-curie-actions-award-297639","The role of Lgr6 as a marker of progenitor cells and cancer-initiating cells in the mammary gland","The epithelial compartments of the mammary gland are thought to be derived from a tissue stem cell capable of self-renewal and differentiating into all cellular lineages of the mammary gland. Detailed studies of normal and tumorigenic breast stem cells have proven rather cumbersome since these cells are rare and a high degree of purification is needed.  Several approaches to isolate mammary stem cells are based on the use of relatively unspecific surface markers, which are also expressed on diff",{"id":719,"funder":7,"programme":8,"title":720,"piName":10,"institution":721,"country":722,"year":13,"amount":10,"abstract":723},"cordis-marie-skłodowska-curie-actions-award-330756","Enlightenment craving for information: the use of questionnaires for knowledge acquisition and exchange during the Eighteenth Century","UNIVERSITY OF GALWAY","IE","The research project aims to deliver a comparative, transnational and multidisciplinary study on Eighteenth-Century questionnaires, exploring the extent to which they were systematically employed to collect, select, manipulate and disseminate information. Questionnaires  offer a valuable example to examine how local knowledge was systematized within a rigid structure, transferred and implemented in another context (cultural transfer). By examining a few chosen case-studies comparatively and by a",{"id":725,"funder":7,"programme":8,"title":726,"piName":10,"institution":721,"country":722,"year":13,"amount":10,"abstract":727},"cordis-marie-skłodowska-curie-actions-award-298099","“Synthesis and biological activity of Cu(II) metallonucleases that target tumour cells”","Dr. Diego Montagner, an Italian national who is working as a postdoc in the group of Prof. B. Longato (Padua University), is making an application to this programme to move to NUI Galway in Ireland, where he is currently spending a period as Visiting Scientist in the group of Dr. A. Erxleben, to carry out a project for 24 months in the area of medicinal inorganic chemistry.This proposal specifically deals with the synthesis of Cu(II) complexes that selectively target tumour cells and act as arti",{"id":729,"funder":7,"programme":8,"title":730,"piName":10,"institution":708,"country":40,"year":13,"amount":10,"abstract":731},"cordis-marie-skłodowska-curie-actions-award-328758","Combining sensitive biomarkers for early diagnosis of AD: A multi-modal approach","Alzheimer’s disease (AD) is currently the leading cause of dementia, being expected to double in the coming decades. Increasing evidence suggests the pathological mechanisms of AD become active several years before neurons start dying and dementia manifests. During this prodromal stage, referred to as Mild Cognitive Impairment (MCI), effective treatments would have the greatest impact because cognitive function is still relatively preserved. Hence, it is crucial to identify these subjects at inc",{"id":733,"funder":7,"programme":8,"title":734,"piName":10,"institution":708,"country":40,"year":13,"amount":10,"abstract":735},"cordis-marie-skłodowska-curie-actions-award-303313","The Physiological Control of Stem Cells: Obesity, Insulin, and Neural Stem Cell Dynamics","Stem cells are essential to the homeostasis, repair, and function of the tissues in which they reside. Stem cells can be regulated by systemic endocrine signals, meaning environmental factors that impact physiological state, such as diet, infection, and societal stress, can greatly impact stem cell function. Neural stem cells (NSCs) in the hippocampus divide to generate new neurons in the adult, and are known to be regulated by environmental factors.Diet-induced obesity is a modern epidemic, lea",{"id":737,"funder":7,"programme":8,"title":738,"piName":10,"institution":739,"country":104,"year":13,"amount":10,"abstract":740},"cordis-marie-skłodowska-curie-actions-award-331131","Determinants of the switch from R5- to X4-tropic virus in HIV-1 infected individuals","UNIVERSITAIR MEDISCH CENTRUM UTRECHT","HIV-1 variants utilizing CCR5 (R5) are predominant during early infection, emergence of CXCR4 (X4) strains typically occurs later. Although R5 to X4 switch is strongly correlated with increased rates of disease progression, it remains largely unknown which factors are causing the switch. Based on our preliminary data we postulate that both host (immune activation) and viral factors (target cell affinity) are required for switching.A) We hypothesize that high levels of immune activation predispos",{"id":742,"funder":7,"programme":8,"title":743,"piName":10,"institution":739,"country":104,"year":13,"amount":10,"abstract":744},"cordis-marie-skłodowska-curie-actions-award-328666","Functional analysis of RasGRP1 SNPs in autoimmune disease","Autoimmunity is caused by chronic inflammation mediated by T- and B-lymphocytes. Thus far, treatment of autoimmunity consists of general immune suppressants, causing unwarranted side effects, without curing disease. Therefore, the need for a specific treatment targeting the cause of disease is growing. In this fellowship will focus on elucidating how SNPs (single nucleotide polymorphisms) in RasGRP1 play a role in aberrant lymphocyte activity in patients with autoimmunity. RasGRP1 is critical in",{"id":746,"funder":7,"programme":8,"title":747,"piName":10,"institution":748,"country":104,"year":13,"amount":10,"abstract":749},"cordis-marie-skłodowska-curie-actions-award-331388","Cellular protein damage control: interactomic analyses of MOAG-4 in C. elegans","ACADEMISCH ZIEKENHUIS GRONINGEN","Several age-related neurodegenerative disorders, such as Alzheimer’s, Parkinson’s and Huntington’s diseases, are characterized by the formation of pathogenic proteins aggregates in the brain. Although some regulators have been identified, how aggregates form during aging is poorly understood.Recently, a modifier of aggregation, MOAG-4, was identified as a positive regulator of aggregation in C. elegans models for neurodegenerative diseases. The role of MOAG-4 is evolutionarily conserved in the h",{"id":751,"funder":7,"programme":8,"title":752,"piName":10,"institution":753,"country":155,"year":13,"amount":10,"abstract":754},"cordis-marie-skłodowska-curie-actions-award-300452","Understanding the organisation of the medial parietal cortex: Sensorimotor integration for goal-directed behaviour","ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA","Like other primates, we use our hands extensively to explore and interact with objects in the environment, guided by sensory information. One of the brain regions known to be involved in the direction of arm movements is the medial parietal cortex, which is the focus of the present study. Stroke affecting this part of the brain causes disability, as people become unable to reach accurately to objects of interest. Revealing the brain circuitry responsible for skilled arm movements can have profou",{"id":756,"funder":7,"programme":8,"title":757,"piName":10,"institution":753,"country":155,"year":13,"amount":10,"abstract":758},"cordis-marie-skłodowska-curie-actions-award-328405","New trends in microwave spectroscopy","The available microwave technique can supply precise information on conformation, structure, bond energy, internal motions and, sometimes, on charge distribution within molecules and molecular complexes. A lot of improvements are now possible in MW spectroscopy with the chirped-pulse Fourier transform microwave spectrometer (CP-FTMW) invented by Prof. Brooks Pate in recent years. The objectives of this project are to progress significantly in this field. The evolutionary improvements applied to ",{"id":760,"funder":7,"programme":8,"title":761,"piName":10,"institution":762,"country":70,"year":13,"amount":10,"abstract":763},"cordis-marie-skłodowska-curie-actions-award-327243","Neandertal spine and thorax anatomy: 3D reconstruction, ontogeny and phylogeny","MUSEUM NATIONAL D'HISTOIRE NATURELLE","The vertebral column and thorax are key anatomical regions in human evolution to understand upright bipedal posture and locomotion in terms of weight transmission, equilibrium, habitual loading and kinematics. Additionally, the vertebral column protects the spinal cord, and the size of the spine canal can offer a glimpse into the neurological basis on which throwing abilities and speech evolved, among others. Finally the study of the size of the thorax due to its relation to lung size and thus t",{"id":765,"funder":7,"programme":8,"title":766,"piName":10,"institution":748,"country":104,"year":13,"amount":10,"abstract":767},"cordis-marie-skłodowska-curie-actions-award-332402","Mental representations of and adaptation to the speech signal transmitted via cochlear implants: How the impoverished signal finds its way to the mental lexicon","Cochlear implants (CIs) allow many people to re-gain their speech perception. After implantation listeners need to adapt to a very different sensory experience and the CI transmits only parts and patterns of the information that is present in the acoustically rich natural signal. There are individual differences in the success of this adaptation. This study aims at examining causes of individual variation by relating speech processing with CI to models of speech perception in native and non-nati",{"id":769,"funder":7,"programme":8,"title":770,"piName":10,"institution":771,"country":88,"year":13,"amount":10,"abstract":772},"cordis-marie-skłodowska-curie-actions-award-330249","Climate and nutrient impacts on lake biodiversity and ecosystem functioning","AARHUS UNIVERSITET","Freshwater biodiversity is declining at an alarming and unprecedented rate due to the concomitant impact of several anthropogenic pressures. Recent studies indicate that climate change will markedly exacerbate eutrophication problems through a complex set of mechanisms yet to be clarified. The additive effects of climate change and eutrophication may further deteriorate freshwater biodiversity and induce a major shift in ecosystem metabolism towards stronger emission of greenhouse gases. Thus, t",{"id":774,"funder":7,"programme":8,"title":775,"piName":10,"institution":776,"country":200,"year":13,"amount":10,"abstract":777},"cordis-marie-skłodowska-curie-actions-award-326736","Biomethylation and Biovolatilisation of Arsenic in Soils: Using Carbon and Hydrogen Isotopes to Unravel the Mechanisms and Pathways Involved","UNIVERSITAET BERN","Arsenic (As) is a ubiquitous element found in almost every environmental compartment. Moreover, inorganic As is a Class 1 non-threshold carcinogen and globally, millions of people are at risk, mainly through drinking tainted water which is also used to irrigate agricultural soils.As is found in soils in its inorganic form but also as organic As, mostly mono- and dimethylarsenic (MMA(V) and DMAV(V), (III) and (V) being the different oxidation states). The process leading to these compounds, biome",{"id":779,"funder":7,"programme":8,"title":780,"piName":10,"institution":781,"country":104,"year":13,"amount":10,"abstract":782},"cordis-marie-skłodowska-curie-actions-award-301554","From nanolayers to solar cells: Advanced in-situ optical characterization of thin-film materials","TECHNISCHE UNIVERSITEIT EINDHOVEN","This project aims at the development of advanced surface-sensitive characterization methods for  PHOTOVOLTAICS (PV) MATERIALS RESEARCH within the framework of  enhancement of mutual collaboration between the European host research group at TU-Eindhoven and the applicant's  group of origin at UT-Dallas (USA). Nanolayer-engineering based on advanced deposition of ultra-thin oxides becomes an increasingly important subject in the current worldwide efforts to boost solar cells efficiencies. Advanced",{"id":784,"funder":7,"programme":8,"title":785,"piName":10,"institution":771,"country":88,"year":13,"amount":10,"abstract":786},"cordis-marie-skłodowska-curie-actions-award-331159","Non-adiabatic quantum dynamics in novel optical superlattices","The interdisciplinary boundary between the fields of quantum information science, condensed matter, and atomic physics is at the heart of the new field of quantum engineering. One of the most important tools in this domain is ultracold atoms in optical lattices which are an ideal for testing  condensed matter models and realising scalable quantum computation.For pratical implementation of quantum technology the challenge lies in realising the necessary dynamics with sufficient speed, sensitivity",{"id":788,"funder":7,"programme":8,"title":789,"piName":10,"institution":781,"country":104,"year":13,"amount":10,"abstract":790},"cordis-marie-skłodowska-curie-actions-award-301103","Mechanics of Energy Storage Materials: Swelling and Fracturing in Lithium ion Batteries electrodes during Charging\u002FDischarging Cycles","One of the greatest challenges facing the electric power industry is how to deliver the energy in a useable form as a higher-value product, especially in the area of renewable energy. By storing the power produced from immense renewable sources off-peak (e.g., daytime for solar energy) and releasing it during on-peak periods, energy storage can transform low-value, unscheduled power into high-value “green” products.The development of high-energy and high-power storage devices has been one of the",{"id":792,"funder":7,"programme":8,"title":793,"piName":10,"institution":771,"country":88,"year":13,"amount":10,"abstract":794},"cordis-marie-skłodowska-curie-actions-award-327675","Energy and carbon food webs of the deep sub-seafloor biosphere","Vast communities of microorganisms in the sub-seafloor biosphere are responsible for the degradation of deeply buried organic matter (OM) and drive complex metabolic processes of OM mineralization. It remains unknown how the microorganisms subsist at the available energetic limits for life with extremely slow turnover. This project aims to determine the energetic and kinetic controls on the major metabolic processes, in particular the role of small organic acids. These occur in a broad range of ",{"id":796,"funder":7,"programme":8,"title":797,"piName":10,"institution":520,"country":28,"year":13,"amount":10,"abstract":798},"cordis-marie-skłodowska-curie-actions-award-329798","Climate change and sea turtles","Climate change is impacting ecosystems and organisms around the world. Sea turtles bury their eggs in sand and need stable conditions of moisture and temperature for successful development of eggs and emergence of hatchlings to the surface. We have recently shown that leatherback turtles (Dermochelys coriacea) are susceptible to climate change in Central America, because of the effects of precipitation and air temperature on egg development and hatchling emergence. We propose to analyze the glob",{"id":800,"funder":7,"programme":8,"title":801,"piName":10,"institution":520,"country":28,"year":13,"amount":10,"abstract":802},"cordis-marie-skłodowska-curie-actions-award-300508","Biotechnological exploitation of Pseudomonas putida: Lego-lizing and refactoring central metabolic blocks through rational genome engineering","Pseudomonads include a diverse set of bacteria with metabolic versatility and genetic plasticity that enable their survival in a broad range of environments. Many members of this family are able to both degrade toxic compounds and efficiently produce high value bioproducts, and they are of interest for bioremediation endeavors as well as in bulk production of biochemicals. The present project aims at undertaking a deep genetic and metabolic engineering of Pseudomonas putida KT2440 in order to de",{"id":804,"funder":7,"programme":8,"title":805,"piName":10,"institution":520,"country":28,"year":13,"amount":10,"abstract":806},"cordis-marie-skłodowska-curie-actions-award-298960","Multi-leg precision calculations and advanced phenomenology in the LHC era","The Large Hadron Collider (LHC) running actually at CERN, Geneva, is the most powerful man made high energy particle collider.  It will enable us to observe or exclude the Standard Model Higgs boson, to clarify the nature of the electroweak symmetry breaking (EWSB) and to find possible signals of physics beyond the Standard Model (SM).Search for new physics signals at the CERN LHC frequently involves multi-particle final states, consisting of jets, leptons, photons and missing energy. Meaningful",{"id":808,"funder":7,"programme":8,"title":809,"piName":10,"institution":520,"country":28,"year":13,"amount":10,"abstract":810},"cordis-marie-skłodowska-curie-actions-award-301287","Active Control Of Cavity Tones In Aircrafts","Airframe noise is equal to or louder than engine noise during the landing approach of a commercial aircraft. With the growth of air traffic as well as the ever increasing level of urbanisation around most airports in Europe, the annoyance near airports is increasing, and the environmental concerns and noise certification regulations make the study of airframe noise an important research topic. The European Commission, within the Advisory Council for Aeronautics Research in Europe (ACARE) has set",{"id":812,"funder":7,"programme":8,"title":813,"piName":10,"institution":520,"country":28,"year":13,"amount":10,"abstract":814},"cordis-marie-skłodowska-curie-actions-award-328144","Autonomous Paper-based Point-of-Care Biosensing System","The objective of this proposal is the development of a fuel cell powered point-of-care analytical device based on paper microfluidics. The device would comprise a power source, biosensors, electronics module and display, to allow the autonomous quantitative measurement of a biological sample and visualize the results within a thin, flexible and disposable package. A first phase of the project (outgoing) will be dedicated to acquiring the skills and methodology to develop paper-based microfluidic",{"id":816,"funder":7,"programme":8,"title":817,"piName":10,"institution":520,"country":28,"year":13,"amount":10,"abstract":818},"cordis-marie-skłodowska-curie-actions-award-327563","Avant Garde Approaches to Processable multiscale conjugated polymer hybrid materials with enhanced Electronic properties and water-repellency","This project aims to circumvent the most severe flaws of Conjugated Polymers (CPs hereafter), namely their processability and stability, while not compromising or even improving their electronic performance. Approaches are presented that will produce performing, water-repellent and processable CPs to feed the emergent Hydrophobic Electronics. A procedure will be developed to allow the CPs grafting on OH-containing nanoparticles profiting of the applicant’s knowledge on NHC catalysts, acquired al",{"id":820,"funder":7,"programme":8,"title":821,"piName":10,"institution":520,"country":28,"year":13,"amount":10,"abstract":822},"cordis-marie-skłodowska-curie-actions-award-328287","Metagenomic analysis of viral and microbial communities from global high-latitude pristine environments as a model to understand the influence of viruses on the ecosystem","Pristine, high-latitude freshwater ecosystems represent some of the last unaltered habitats on the planet. These ecosystems commonly present limited nutrient input and are dominated by microorganisms, commonly presenting very small meso- and macroorganism communities, which translates into relatively simple natural ecosystems with short food-webs. Microorganism communities are regulated by the availability of nutrients (bottom-up control), the activity of predators (top-down control), and viral ",{"id":824,"funder":7,"programme":8,"title":825,"piName":10,"institution":520,"country":28,"year":13,"amount":29,"abstract":826},"cordis-marie-skłodowska-curie-actions-award-302562","Continuous measurements of plankton and environmental variables: towards assessment of phytoplankton community response to environmental change","Phytoplankton dynamics are highly variable in coastal ecosystems because physical, chemical and biological influences are forced in complex ways. Many important processes that influence coastal phytoplankton dynamics are episodic (e.g. hurricanes, storms and seiches). However, phytoplankton variability at short-term scales is poorly understood. Despite that alteration of the magnitude and frequency of episodic events (storms, rains, droughts) is considered one of the consequences of future globa",{"id":828,"funder":7,"programme":8,"title":829,"piName":10,"institution":520,"country":28,"year":13,"amount":10,"abstract":830},"cordis-marie-skłodowska-curie-actions-award-332274","PROTEOMICS AND SYSTEMS BIOLOGY OF FISH ALLERGY","Food allergy is considered one of the major concerns in food safety. The prevalence of this type of IgE-mediated allergy has been increasing during the last two decades (6-8% of children\u002F2-4% of adults). Fish is one of the most frequent causes of this type of allergy. The symptoms appear within 60 min of exposure and include acute urticaria, nauseas, wheezing and asthma. In the most severe cases, anaphylaxis shocks can potentially life threatening.To guarantee consumers security, a number of reg",{"id":832,"funder":7,"programme":8,"title":833,"piName":10,"institution":520,"country":28,"year":13,"amount":10,"abstract":834},"cordis-marie-skłodowska-curie-actions-award-330925","Unravelling the function of integrins in the unicellular relatives of Metazoa","The integrins are a superfamily of the major cell adhesion receptors that bind primarily to extracellular matrix ligands, typically short peptide motifs such as arginine-glycine-aspartate – RGD, but can also bind to cell-surface ligands and soluble ligands. Integrin heterodimers bind and interact with several other proteins forming the integrin-mediated adhesion and two-way signalling complex. This complex consists of alpha-actinin and talin which bind to the cytoplasmic C-terminal tail of the i",{"id":836,"funder":7,"programme":8,"title":837,"piName":10,"institution":520,"country":28,"year":13,"amount":10,"abstract":838},"cordis-marie-skłodowska-curie-actions-award-327127","Alexander von Humboldt and the Globalization of Science: Networks of Knowledge between Germany and the United States in the 19th Century","This research project proposes a systematic analysis and reinterpretation of the Prussian explorer Alexander von Humboldt as a critical figure in the study of the globalization of knowledge through the creation of transatlantic scientific networks. Humboldt’s outstanding impact on the progress of science extended beyond his contribution to particular fields of knowledge: Through his intricate networks with other scholars, established to discuss research questions, exchange data, and compare thei",{"id":840,"funder":7,"programme":8,"title":841,"piName":10,"institution":842,"country":200,"year":13,"amount":10,"abstract":843},"cordis-marie-skłodowska-curie-actions-award-303114","Mapping Spatial Interaction Networks in Honeybee Colonies","UNIVERSITE DE LAUSANNE","When individuals that live in extended family groups- such as honeybees- the entire society is vulnerable to infection of just a single colony-member, as the same networks that are optimised for efficient transmission of information or food, may be hijacked by the pathogen. Nevertheless, mechanisms have evolved to reduce the spread of disease across social or communication networks. For example, infected ants commit altruistic suicide by removing themselves from the colony entirely. Similarly, t",{"id":845,"funder":7,"programme":8,"title":846,"piName":10,"institution":520,"country":28,"year":13,"amount":10,"abstract":847},"cordis-marie-skłodowska-curie-actions-award-301216","Tipping Points in Ecological Networks","Ecosystems occasionally respond abruptly to small changes in external conditions. Such abrupt responses can represent critical transitions that occur at tipping points where the ecosystem shifts to an alternative regime. Despite the often profound consequences of tipping events, our ability to predict them is still limited. To meet this challenge, generic early-warning signals for critical transitions have recently been proposed. These signals are generic, because they may in principle work irre",{"id":849,"funder":7,"programme":8,"title":850,"piName":10,"institution":520,"country":28,"year":13,"amount":10,"abstract":851},"cordis-marie-skłodowska-curie-actions-award-328911","Studying Micro-Scale Socio-Ecological Development In Marginal Zones: An Integrated Methodology","The proposed research is to develop a multi-disciplinary approach to investigate socio-ecological networks in marginal regions at local scale. Locality and marginality have been often overlooked but are focal points in understanding the complex relationships between environment and human populations. Marginal alluvial zones bore witness to the development of agricultural and subsequently urban societies, and continue to represent one of the most exploited (but fragile) environments on our planet",{"id":853,"funder":7,"programme":8,"title":854,"piName":10,"institution":520,"country":28,"year":13,"amount":10,"abstract":855},"cordis-marie-skłodowska-curie-actions-award-329682","Integrative Modeling and Engineering of Pseudomonas putida for Green Chemistry","The widespread use of fossil based fuels and plastics is a major cause of environmental pollution, and their production depends on limited non-renewable oil resources. The immense diversity of catalytic processes encoded in the genomes of sequenced organisms holds the promise of developing biotechnological systems for the efficient production of renewable energy sources and degradable materials via genetic engineering. However, the combinatorial possibilities for integrating enzyme-coding genes ",{"id":857,"funder":7,"programme":8,"title":858,"piName":10,"institution":748,"country":104,"year":13,"amount":10,"abstract":859},"cordis-marie-skłodowska-curie-actions-award-298698","Systems Networks Norms","Genomic sciences are driving progress in biology at an unprecedented pace, most recently through third-generation sequencing and synthetic biology. These achievements challenge commonly accepted biological concepts and assumptions in the humanities. In this Fellowship I will investigate the impact of genomic sciences on theory development in the social and human sciences, with focus on philosophy and ethics, and develop innovative normative models that align with this new knowledge. Harvard Univ",{"id":861,"funder":7,"programme":8,"title":862,"piName":10,"institution":863,"country":104,"year":13,"amount":10,"abstract":864},"cordis-marie-skłodowska-curie-actions-award-328695","Genomic screening of the Embryo for Novel targets in the tumor Endothelium","STICHTING VU","Several angiogenesis inhibitors are in the market for treatment of cancer, but efficiency in terms of prolongation of survival is still very moderate. This can be explained by induction of resistance to therapy, since most agents neutralize tumor produced growth factors.An alternative and preferred strategy would be to directly target the tumor endothelial cells, which will not easily mutate to resist treatment due to genetic stability. It is hypothesized that by mining the pool of genes that ha",{"id":866,"funder":7,"programme":8,"title":867,"piName":10,"institution":863,"country":104,"year":13,"amount":10,"abstract":868},"cordis-marie-skłodowska-curie-actions-award-331893","Introducing stacking and halogen bonding effects into ligand-target interaction energy calculations","The subject of the present proposal is computational chemistry with specific aim to incorporate certain interactions into docking calculations. The docking technique helps the design and synthesis of efficient pharmaceuticals that act via ligand–receptor interactions. In the frame of the project, new scoring function (SF) term(s) will be introduced for selected interactions (π – π stacking and halogen bonds) using experimental enthalpic data and combined quantum-mechanical\u002Fmolecular-mechanical c",{"id":870,"funder":7,"programme":8,"title":871,"piName":10,"institution":863,"country":104,"year":13,"amount":10,"abstract":872},"cordis-marie-skłodowska-curie-actions-award-329245","Strictly-correlated Density Functional Theory: methodology development and application to semiconductor nanostructures and ultracold atom gases","This project has two main objectives: First, to further develop and generalize the formalism of strictly-correlated Density Functional Theory (SC DFT), which is ideally suited for the study of strongly-interacting systems. Second, to apply it to the study of both semiconductor nanostructures and ultracold atom gases. This novel methodology was recently proposed by the head scientist of the project and co-workers and, despite being still in its early stage, it has already shown an enormous potent",{"id":874,"funder":7,"programme":8,"title":875,"piName":10,"institution":876,"country":183,"year":13,"amount":10,"abstract":877},"cordis-marie-skłodowska-curie-actions-award-326640","A Network Approach to Urbanization and Processes of Invention\u002FInnovation in the Material Culture of Bronze Age Crete (3100-1200 BCE)","UNIVERSITE CATHOLIQUE DE LOUVAIN","The project focuses on the relationship between urbanization and processes of invention\u002Finnovation in the material culture of the Bronze Age society of Minoan Crete (3100-1200 BCE).In essence, it first proposes to address issues of settlement growth, layout and elaboration, but also plans to develop a diachronic approach to connections between settlements and to investigate issues of site hierarchies. Methodologically, along with a description of urban infrastructures, the intra-site study will ",{"id":879,"funder":7,"programme":8,"title":880,"piName":10,"institution":881,"country":12,"year":13,"amount":882,"abstract":883},"cordis-marie-skłodowska-curie-actions-award-329346","Advanced Transformation Optical Materials for bio-Imaging and light-Concentration","HERIOT-WATT UNIVERSITY","€294,693","With the dramatic advances in micro- and nano-fabrication methods, we are presented with the opportunity to control light in a way that was not possible with the materials provided to us by nature. In an artificial pattern of sub-wavelength elements, the propagation of electromagnetic energy can be defined by an equivalent spatial and spectral dispersion of effective dielectric and magnetic properties. Transformation optics (TO) is a new paradigm for the science of light, which is enabled by rec",{"id":885,"funder":7,"programme":8,"title":886,"piName":10,"institution":863,"country":104,"year":13,"amount":10,"abstract":887},"cordis-marie-skłodowska-curie-actions-award-303197","Bringing Obesity to Light - Do obesogenic chemicals affect lipid metabolism through changes in circadian rhythm?","Bringing light to obesity will elucidate the interconnecting steps of two important signaling pathways i.e. circadian signaling and lipid metabolism. An increase in serum cholesterol level in shift workers indicates this link. Also obesogenic chemicals might influence lipid metabolism through changes in circadian rhythm.Research on obesity has gained in importance as the number of affected patients increases world-wide. 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