[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-veni-2014":3,"awarded-stats-nwo-veni":42},{"awarded":4,"total":41},[5,16,23,29,35],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-11188","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Veni","Molecular mechanism of allosteric modulation at\u003Cscp>GPCRs\u003C\u002Fscp>: insight from a binding kinetics study at the human\u003Cscp>A\u003C\u002Fscp>\u003Csub>1\u003C\u002Fsub>adenosine receptor","Laura H. Heitman","Leiden University","NL",2014,null,"BACKGROUND AND PURPOSE: Many GPCRs can be allosterically modulated by small-molecule ligands. This modulation is best understood in terms of the kinetics of the ligand-receptor interaction. However, many current kinetic assays require at least the (radio)labelling of the orthosteric ligand, which is impractical for studying a range of ligands. Here, we describe the application of a so-called competition association assay at the adenosine A1 receptor for this purpose. EXPERIMENTAL APPROACH: We us",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":21,"year":13,"amount":14,"abstract":22},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-dk","Detection of alterations in membrane metabolism during neoadjuvant chemotherapy in patients with breast cancer using phosphorus magnetic resonance spectroscopy at 7 Tesla","Wybe JM van der Kemp","University Hospital Heidelberg","DE","Here we investigate the feasibility of tumor metabolism monitoring in T1c to T3 breast cancer during neoadjuvant chemotherapy by means of phosphorus ((31)P) magnetic resonance spectroscopy at 7 tesla (T). Five breast cancer patients were examined using a (31)P MRSI sequence, prior to-, halfway-, and after neoadjuvant chemotherapy. The (31)P MRSI data were analyzed on group and individual level and compared to a spectrum of a group of healthy volunteers. Ratios of phosphomonoesters (PME) to phosp",{"id":24,"funder":7,"programme":8,"title":25,"piName":26,"institution":27,"country":12,"year":13,"amount":14,"abstract":28},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-12464","Aerobic C–H Olefination of Indoles via a Cross-Dehydrogenative Coupling in Continuous Flow","Hannes P. L. Gemoets","Eindhoven University of Technology","Herein, we report the first site-selective, Pd(II)-catalyzed, cross-dehydrogenative Heck reaction of indoles in micro flow. By use of a capillary microreactor, we were able to boost the intrinsic kinetics to accelerate former hour-scale reaction conditions in batch to the minute range in flow. The synergistic use of microreactor technology and oxygen, as both terminal oxidant and mixing motif, highlights the sustainable aspect of this process.",{"id":30,"funder":7,"programme":8,"title":31,"piName":32,"institution":33,"country":12,"year":13,"amount":14,"abstract":34},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-916-12-041","TLR4 Accessory Molecule RP105 (CD180) Regulates Monocyte-Driven Arteriogenesis in a Murine Hind Limb Ischemia Model","A. Yaël Nossent","Leiden University Medical Center","AIMS: We investigated the role of the TLR4-accessory molecule RP105 (CD180) in post-ischemic neovascularization, i.e. arteriogenesis and angiogenesis. TLR4-mediated activation of pro-inflammatory Ly6Chi monocytes is crucial for effective neovascularization. Immunohistochemical analyses revealed that RP105+ monocytes are present in the perivascular space of remodeling collateral arterioles. As RP105 inhibits TLR4 signaling, we hypothesized that RP105 deficiency would lead to an unrestrained TLR4-",{"id":36,"funder":7,"programme":8,"title":37,"piName":38,"institution":39,"country":12,"year":13,"amount":14,"abstract":40},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-451-12-009","No Perisaccadic Mislocalization with Abruptly Cancelled Saccades","Jeroen Atsma","Radboud University Nijmegen","Every saccadic eye movement that we make changes the image of the world on our retina. Yet, despite these retinal shifts, we still perceive our visual world to be stable. Efference copy from the oculomotor system to the visual system has been suggested to contribute to this stable percept, enabling the brain to anticipate the retinal image shifts by remapping the neural image. A psychophysical phenomenon that has been linked to this predictive remapping is the mislocalization of a stimulus flash",5,{"programme":8,"total":43,"withPiName":43,"firstYear":44,"lastYear":45,"countryCount":46,"perYear":47,"topInstitutions":92,"topCountries":152},779,1999,2026,32,[48,50,53,56,57,60,63,66,69,72,75,78,81,84,87,90],{"year":44,"count":49},3,{"year":51,"count":52},2011,2,{"year":54,"count":55},2013,4,{"year":13,"count":41},{"year":58,"count":59},2015,14,{"year":61,"count":62},2016,26,{"year":64,"count":65},2017,34,{"year":67,"count":68},2018,80,{"year":70,"count":71},2019,27,{"year":73,"count":74},2020,42,{"year":76,"count":77},2021,51,{"year":79,"count":80},2022,56,{"year":82,"count":83},2023,103,{"year":85,"count":86},2024,110,{"year":88,"count":89},2025,139,{"year":45,"count":91},83,[93,96,98,100,102,104,106,109,112,114,116,119,122,125,126,128,131,134,137,140,142,144,146,148,150],{"name":94,"count":95},"Utrecht University",76,{"name":39,"count":97},58,{"name":99,"count":77},"University of Groningen",{"name":11,"count":101},40,{"name":103,"count":101},"University of Amsterdam",{"name":105,"count":71},"Wageningen University & Research",{"name":107,"count":108},"Vrije Universiteit Amsterdam",24,{"name":110,"count":111},"Delft University of Technology",23,{"name":27,"count":113},17,{"name":115,"count":113},"University of Twente",{"name":117,"count":118},"University Medical Center Groningen",15,{"name":120,"count":121},"Erasmus MC",13,{"name":123,"count":124},"Amsterdam University Medical Centers",10,{"name":33,"count":124},{"name":127,"count":124},"Tilburg University",{"name":129,"count":130},"Erasmus University Rotterdam",9,{"name":132,"count":133},"Amsterdam Neuroscience",8,{"name":135,"count":136},"University Medical Center Utrecht",7,{"name":138,"count":139},"Centre National de la Recherche Scientifique",6,{"name":141,"count":139},"Royal Netherlands Institute for Sea Research",{"name":143,"count":139},"University of Copenhagen",{"name":145,"count":41},"Amsterdam University of Applied Sciences",{"name":147,"count":41},"Institute for Atomic and Molecular Physics",{"name":149,"count":41},"Maastricht University",{"name":151,"count":41},"Maastricht University Medical Centre",[153,155,157,159,162,165,167,169,171,173,175,177,179,181,183,185,187,189,191,193,195,197,200,202,204],{"name":12,"count":154},551,{"name":156,"count":62},"US",{"name":21,"count":158},19,{"name":160,"count":161},"GB",18,{"name":163,"count":164},"FR",12,{"name":166,"count":130},"DK",{"name":168,"count":133},"IT",{"name":170,"count":136},"CZ",{"name":172,"count":139},"AT",{"name":174,"count":139},"AU",{"name":176,"count":139},"BE",{"name":178,"count":139},"ES",{"name":180,"count":41},"CA",{"name":182,"count":41},"CN",{"name":184,"count":41},"PL",{"name":186,"count":41},"ZA",{"name":188,"count":55},"NO",{"name":190,"count":49},"SE",{"name":192,"count":52},"CH",{"name":194,"count":52},"FI",{"name":196,"count":52},"IN",{"name":198,"count":199},"JP",1,{"name":201,"count":199},"KR",{"name":203,"count":199},"LK",{"name":205,"count":199},"MK"]