[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"awarded-nwo-veni-2016":3,"awarded-stats-nwo-veni":147},{"awarded":4,"total":146},[5,16,22,27,29,34,40,46,52,54,60,67,72,78,83,88,94,99,104,109,115,120,125,131,136,141],{"id":6,"funder":7,"programme":8,"title":9,"piName":10,"institution":11,"country":12,"year":13,"amount":14,"abstract":15},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-916-12-154","Nederlandse Organisatie voor Wetenschappelijk Onderzoek","NWO Veni","ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study","Abbas Dehghan","Erasmus MC","NL",2016,null,"AIMS\u002FHYPOTHESIS: ADAMTS13 is a protease that breaks down von Willebrand factor (VWF) multimers into smaller, less active particles. VWF has been associated with an increased risk of incident type 2 diabetes mellitus. Here, we determine whether ADAMTS13 activity and VWF antigen are associated with incident diabetes. METHODS: This study included 5176 participants from the Rotterdam Study, a prospective population-based cohort study. Participants were free of diabetes at baseline and followed up fo",{"id":17,"funder":7,"programme":8,"title":18,"piName":19,"institution":20,"country":21,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-alw-veni-grant-863-13-018","Vagal Blocking for Obesity Control: a Possible Mechanism-Of-Action","Duan Chen","Norwegian University of Science and Technology","NO",{"id":23,"funder":7,"programme":8,"title":24,"piName":25,"institution":11,"country":12,"year":13,"amount":14,"abstract":26},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-91616058-to-ps","Evaluation of the Antigen-Experienced B-Cell Receptor Repertoire in Healthy Children and Adults","Mirjam van der Burg","Upon antigen recognition via their B cell receptor (BR), B cells migrate to the germinal center where they undergo somatic hypermutation (SHM) to increase their affinity for the antigen, and class switch recombination (CSR) to change the effector function of the secreted antibodies. These steps are essential to create an antigen-experienced BR repertoire that efficiently protects the body against pathogens. At the same time, the BR repertoire should be selected to protect against responses to se",{"id":28,"funder":7,"programme":8,"title":24,"piName":25,"institution":11,"country":12,"year":13,"amount":14,"abstract":26},"openalex-nederlandse-organisatie-voor-wetenschapp-award-vidi-grant-91712323-to-mb-veni-grant-91616058-to-ps",{"id":30,"funder":7,"programme":8,"title":31,"piName":32,"institution":11,"country":12,"year":13,"amount":14,"abstract":33},"openalex-nederlandse-organisatie-voor-wetenschapp-award-zonmw-veni-916-12-154","The role of epigenetic modifications in cardiovascular disease: A systematic review","Taulant Muka","BACKGROUND: Epigenetic modifications of the genome, such as DNA methylation and histone modifications, have been reported to play a role in processes underlying cardiovascular disease (CVD), including atherosclerosis, inflammation, hypertension and diabetes. METHODS: Eleven databases were searched for studies investigating the association between epigenetic marks (either global, site-specific or genome-wide methylation of DNA and histone modifications) and CVD. RESULTS: Of the 3459 searched refe",{"id":35,"funder":7,"programme":8,"title":36,"piName":37,"institution":38,"country":12,"year":13,"amount":14,"abstract":39},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-916-10-138","The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein","Emmanuel J. H. J. Wiertz","University Medical Center Utrecht","Misfolded proteins from the endoplasmic reticulum (ER) are transported back into the cytosol for degradation via the ubiquitin-proteasome system. The human cytomegalovirus protein US11 hijacks this ER-associated protein degradation (ERAD) pathway to downregulate human leukocyte antigen (HLA) class I molecules in virus-infected cells, thereby evading elimination by cytotoxic T-lymphocytes. Recently, we identified the E3 ubiquitin ligase transmembrane protein 129 (TMEM129) as a key player in this ",{"id":41,"funder":7,"programme":8,"title":42,"piName":43,"institution":44,"country":12,"year":13,"amount":14,"abstract":45},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-639-021-124","Inter‐station intensity standardization for whole‐body\u003Cscp>MR\u003C\u002Fscp>data","Oleh Dzyubachyk","Leiden University Medical Center","PURPOSE: To develop and validate a method for performing inter-station intensity standardization in multispectral whole-body MR data. METHODS: Different approaches for mapping the intensity of each acquired image stack into the reference intensity space were developed and validated. The registration strategies included: \"direct\" registration to the reference station (Strategy 1), \"progressive\" registration to the neighboring stations without (Strategy 2), and with (Strategy 3) using information ",{"id":47,"funder":7,"programme":8,"title":48,"piName":49,"institution":50,"country":12,"year":13,"amount":14,"abstract":51},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-863-15-020","Delayed dispersal and the costs and benefits of different routes to independent breeding in a cooperatively breeding bird","Jan Komdeur","University of Groningen","Why sexually mature individuals stay in groups as nonreproductive subordinates is central to the evolution of sociality and cooperative breeding. To understand such delayed dispersal, its costs and benefits need to be compared with those of permanently leaving to float through the population. However, comprehensive comparisons, especially regarding differences in future breeding opportunities, are rare. Moreover, extraterritorial prospecting by philopatric individuals has generally been ignored,",{"id":53,"funder":7,"programme":8,"title":48,"piName":49,"institution":50,"country":12,"year":13,"amount":14,"abstract":51},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-863-13-017",{"id":55,"funder":7,"programme":8,"title":56,"piName":57,"institution":58,"country":12,"year":13,"amount":14,"abstract":59},"openalex-nederlandse-organisatie-voor-wetenschapp-award-016-096-049-veni-grant","Modelling the Innate Immune Response against Avian Influenza Virus in Chicken","Thomas J. Hagenaars","Wageningen University & Research","At present there is limited understanding of the host immune response to (low pathogenic) avian influenza virus infections in poultry. Here we develop a mathematical model for the innate immune response to avian influenza virus in chicken lung, describing the dynamics of viral load, interferon-α, -β and -γ, lung (i.e. pulmonary) cells and Natural Killer cells. We use recent results from experimentally infected chickens to validate some of the model predictions. The model includes an initial expo",{"id":61,"funder":7,"programme":8,"title":62,"piName":63,"institution":64,"country":65,"year":13,"amount":14,"abstract":66},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-863-11-011","Over the hills and further away from coast: global geospatial patterns of human and environment over the 20th–21st centuries","Matti Kummu","Aalto University","FI","Proximity to the coast and elevation are important geographical considerations for human settlement. Little is known, however, about how spatial variation in these factors exactly relates to human settlements and activities, and how this has developed over time. Such knowledge is important for identifying vulnerable regions that are at risk from phenomena such as food shortages and water stress. Human activities are a key driving force in global change, and thus detailed information on populatio",{"id":68,"funder":7,"programme":8,"title":69,"piName":70,"institution":38,"country":12,"year":13,"amount":14,"abstract":71},"openalex-nederlandse-organisatie-voor-wetenschapp-award-zonmw-veni-91613008","De novo 14q24.2q24.3 microdeletion including \u003Ci>IFT43\u003C\u002Fi> is associated with intellectual disability, skeletal anomalies, cardiac anomalies, and myopia","Mieke M. van Haelst","We report an 11-year-old girl with mild intellectual disability, skeletal anomalies, congenital heart defect, myopia, and facial dysmorphisms including an extra incisor, cup-shaped ears, and a preauricular skin tag. Array comparative genomic hybridization analysis identified a de novo 4.5-Mb microdeletion on chromosome 14q24.2q24.3. The deleted region and phenotype partially overlap with previously reported patients. Here, we provide an overview of the literature on 14q24 microdeletions and furt",{"id":73,"funder":7,"programme":8,"title":74,"piName":75,"institution":76,"country":12,"year":13,"amount":14,"abstract":77},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-grant-number-275-89-012-awarded-to-a-k-","On the Shallow Processing (Dis)Advantage: Grammar and Economy","Arnout Koornneef","Leiden University","In the psycholinguistic literature it has been proposed that readers and listeners often adopt a \"good-enough\" processing strategy in which a \"shallow\" representation of an utterance driven by (top-down) extra-grammatical processes has a processing advantage over a \"deep\" (bottom-up) grammatically-driven representation of that same utterance. In the current contribution we claim, both on theoretical and experimental grounds, that this proposal is overly simplistic. Most importantly, in the domai",{"id":79,"funder":7,"programme":8,"title":80,"piName":81,"institution":14,"country":14,"year":13,"amount":14,"abstract":82},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-916-151-94","Integrated photoacoustic\u002Fultrasound imaging : Applications and new techniques","Pim van den Berg","Loc at io n s w it h in re ac h",{"id":84,"funder":7,"programme":8,"title":85,"piName":86,"institution":76,"country":12,"year":13,"amount":14,"abstract":87},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-722-014-004","Graphene-stabilized lipid monolayer heterostructures: a novel biomembrane superstructure","Grégory F. Schneider","Chemically defined and electronically benign interfaces are attractive substrates for graphene and other two-dimensional materials. Here, we introduce lipid monolayers as an alternative, structurally ordered, and chemically versatile support for graphene. Deposition of graphene on the lipids resulted in a more ordered monolayer than regions without graphene. The lipids also offered graphene a more uniform and smoother support, reducing graphene hysteresis loop and the average value of the charge",{"id":89,"funder":7,"programme":8,"title":90,"piName":91,"institution":92,"country":12,"year":13,"amount":14,"abstract":93},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-grant-no-680-47-432","State behaviour and dynamics of self-propelled Brownian squares: a simulation study","Vasileios Prymidis","Utrecht University","We study the state behaviour of self-propelled and Brownian squares as a function of the magnitude of self-propulsion and density using Brownian dynamics simulations. We find that the system undergoes a transition from a fluid state to phase coexistence with increased self-propulsion and density. Close to the transition we find oscillations of the system between a fluid state and phase coexistence that are caused by the accumulation of forces in the dense phase. Finally, we study the coarsening ",{"id":95,"funder":7,"programme":8,"title":96,"piName":97,"institution":50,"country":12,"year":13,"amount":14,"abstract":98},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-722-014-006","Intramolecular transport of small-molecule cargo in a nanoscale device operated by light","Ben L. Feringa","An intramolecular cargo transport device, based on a light-driven molecular motor, is presented. Detailed UV-vis and (1)H NMR studies demonstrate that the gripper attached to the upper half of the molecular motor is able to pick up an acetyl group from one side of the lower stator and, after a photochemical Z-E isomerization, drop it on the opposite side.",{"id":100,"funder":7,"programme":8,"title":101,"piName":102,"institution":92,"country":12,"year":13,"amount":14,"abstract":103},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-451-09-018","Tonic immobility differentiates stress responses in \u003Cscp>PTSD\u003C\u002Fscp>","Muriel A. Hagenaars","These preliminary findings suggest that eye closure has a different effect on PTSD patients than controls and that high self-reported TI might indicate a distinct stress response pattern, i.e., a proneness for immobility. It may be relevant to take such individual differences in stress-response into account in PTSD treatment.",{"id":105,"funder":7,"programme":8,"title":48,"piName":106,"institution":107,"country":108,"year":13,"amount":14,"abstract":51},"openalex-nederlandse-organisatie-voor-wetenschapp-award-alw-grant-823-01-014-rubicon-825-11-011-top-854-11-003-veni-863-13-017-veni-863-","Sjouke A. Kingma","University of East Anglia","GB",{"id":110,"funder":7,"programme":8,"title":111,"piName":112,"institution":113,"country":12,"year":13,"amount":14,"abstract":114},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-639-021-022","Does Your Domestic Photovoltaic Energy System Survive Grid Outages?","Marijn Jongerden","University of Twente","Domestic renewable energy systems, including photovoltaic energy generation, as well as local storage, are becoming increasingly popular and economically feasible, but do come with a wide range of options. Hence, it can be difficult to match their specification to specific customer’s needs. Next to the usage-specific demand profiles and location-specific production profiles, local energy storage through the use of batteries is becoming increasingly important, since it allows one to balance varia",{"id":116,"funder":7,"programme":8,"title":117,"piName":118,"institution":92,"country":12,"year":13,"amount":14,"abstract":119},"openalex-nederlandse-organisatie-voor-wetenschapp-award-nwo-veni-722-012-006","Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα","Cristina M. Dorobantu","Encephalomyocarditis virus (EMCV), like hepatitis C virus (HCV), requires phosphatidylinositol 4-kinase IIIα (PI4KA) for genome replication. Here, we demonstrate that tyrphostin AG1478, a known epidermal growth factor receptor (EGFR) inhibitor, also inhibits PI4KA activity, both in vitro and in cells. AG1478 impaired replication of EMCV and HCV but not that of an EMCV mutant previously shown to escape PI4KA inhibition. This work uncovers novel cellular and antiviral properties of AG1478, a compo",{"id":121,"funder":7,"programme":8,"title":122,"piName":123,"institution":92,"country":12,"year":13,"amount":14,"abstract":124},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-451-15-024","Behavioral Public Administration: Combining Insights from Public Administration and Psychology","Stephan Grimmelikhuijsen","Abstract Behavioral public administration is the analysis of public administration from the micro‐level perspective of individual behavior and attitudes by drawing on insights from psychology on the behavior of individuals and groups. The authors discuss how scholars in public administration currently draw on theories and methods from psychology and related fields and point to research in public administration that could benefit from further integration. An analysis of public administration topi",{"id":126,"funder":7,"programme":8,"title":127,"piName":128,"institution":129,"country":108,"year":13,"amount":14,"abstract":130},"openalex-nederlandse-organisatie-voor-wetenschapp-award-now-veni-916-76-125","Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium","Cathryn M. Lewis","King's College London","We demonstrate that using additional phenotype data previously collected by genetic studies to tackle phenotypic heterogeneity in MDD can successfully lead to the discovery of genetic risk factor despite reduced sample size. Furthermore, our results suggest that the genetic susceptibility to MDD differs between adult- and earlier-onset MDD, with earlier-onset cases having a greater genetic overlap with schizophrenia and bipolar disorder.",{"id":132,"funder":7,"programme":8,"title":133,"piName":134,"institution":92,"country":12,"year":13,"amount":14,"abstract":135},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-863-14-020","Population Genetic Structure, Abundance, and Health Status of Two Dominant Benthic Species in the Saba Bank National Park, Caribbean Netherlands: Montastraea cavernosa and Xestospongia muta","Didier M. de Bakker","Saba Bank, a submerged atoll in the Caribbean Sea with an area of 2,200 km2, has attained international conservation status due to the rich diversity of species that reside on the bank. In order to assess the role of Saba Bank as a potential reservoir of diversity for the surrounding reefs, we examined the population genetic structure, abundance and health status of two prominent benthic species, the coral Montastraea cavernosa and the sponge Xestospongia muta. Sequence data were collected from ",{"id":137,"funder":7,"programme":8,"title":138,"piName":139,"institution":140,"country":12,"year":13,"amount":14,"abstract":14},"openalex-nederlandse-organisatie-voor-wetenschapp-award-zonmw-veni-916-66-101","Presynaptic inhibition upon \u003Cscp>CB\u003C\u002Fscp> 1 or \u003Cscp>mG\u003C\u002Fscp> lu2\u002F3 receptor activation requires \u003Cscp>ERK\u003C\u002Fscp> \u002F \u003Cscp>MAPK\u003C\u002Fscp> phosphorylation of Munc18‐1","Sabine Schmitz","Amsterdam Neuroscience",{"id":142,"funder":7,"programme":8,"title":143,"piName":144,"institution":50,"country":12,"year":13,"amount":14,"abstract":145},"openalex-nederlandse-organisatie-voor-wetenschapp-award-veni-grant-no-722-012-010","Confinement properties of 2D porous molecular networks on metal surfaces","Meike Stöhr","Quantum effects that arise from confinement of electronic states have been extensively studied for the surface states of noble metals. Utilizing small artificial structures for confinement allows tailoring of the surface properties and offers unique opportunities for applications. So far, examples of surface state confinement include thin films, artificial nanoscale structures, vacancy and adatom islands, self-assembled 1D chains, vicinal surfaces, quantum dots and quantum corrals. In this revie",26,{"programme":8,"total":148,"withPiName":148,"firstYear":149,"lastYear":150,"countryCount":151,"perYear":152,"topInstitutions":197,"topCountries":252},779,1999,2026,32,[153,155,158,161,164,167,168,171,174,177,180,183,186,189,192,195],{"year":149,"count":154},3,{"year":156,"count":157},2011,2,{"year":159,"count":160},2013,4,{"year":162,"count":163},2014,5,{"year":165,"count":166},2015,14,{"year":13,"count":146},{"year":169,"count":170},2017,34,{"year":172,"count":173},2018,80,{"year":175,"count":176},2019,27,{"year":178,"count":179},2020,42,{"year":181,"count":182},2021,51,{"year":184,"count":185},2022,56,{"year":187,"count":188},2023,103,{"year":190,"count":191},2024,110,{"year":193,"count":194},2025,139,{"year":150,"count":196},83,[198,200,203,204,206,208,209,212,215,218,219,222,224,227,228,230,233,235,237,240,242,244,246,248,250],{"name":92,"count":199},76,{"name":201,"count":202},"Radboud University Nijmegen",58,{"name":50,"count":182},{"name":76,"count":205},40,{"name":207,"count":205},"University of Amsterdam",{"name":58,"count":176},{"name":210,"count":211},"Vrije Universiteit Amsterdam",24,{"name":213,"count":214},"Delft University of Technology",23,{"name":216,"count":217},"Eindhoven University of Technology",17,{"name":113,"count":217},{"name":220,"count":221},"University Medical Center Groningen",15,{"name":11,"count":223},13,{"name":225,"count":226},"Amsterdam University Medical Centers",10,{"name":44,"count":226},{"name":229,"count":226},"Tilburg University",{"name":231,"count":232},"Erasmus University Rotterdam",9,{"name":140,"count":234},8,{"name":38,"count":236},7,{"name":238,"count":239},"Centre National de la Recherche Scientifique",6,{"name":241,"count":239},"Royal Netherlands Institute for Sea Research",{"name":243,"count":239},"University of Copenhagen",{"name":245,"count":163},"Amsterdam University of Applied Sciences",{"name":247,"count":163},"Institute for Atomic and Molecular Physics",{"name":249,"count":163},"Maastricht University",{"name":251,"count":163},"Maastricht University Medical Centre",[253,255,257,260,262,265,267,269,271,273,275,277,279,281,283,285,287,288,290,292,293,295,298,300,302],{"name":12,"count":254},551,{"name":256,"count":146},"US",{"name":258,"count":259},"DE",19,{"name":108,"count":261},18,{"name":263,"count":264},"FR",12,{"name":266,"count":232},"DK",{"name":268,"count":234},"IT",{"name":270,"count":236},"CZ",{"name":272,"count":239},"AT",{"name":274,"count":239},"AU",{"name":276,"count":239},"BE",{"name":278,"count":239},"ES",{"name":280,"count":163},"CA",{"name":282,"count":163},"CN",{"name":284,"count":163},"PL",{"name":286,"count":163},"ZA",{"name":21,"count":160},{"name":289,"count":154},"SE",{"name":291,"count":157},"CH",{"name":65,"count":157},{"name":294,"count":157},"IN",{"name":296,"count":297},"JP",1,{"name":299,"count":297},"KR",{"name":301,"count":297},"LK",{"name":303,"count":297},"MK"]